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See detailQuantitative dilatometric analysis of intercritical annealing in a low-silicon TRIP steel
Zhao, Lie; Kop, T. A.; Rolin, Valéry et al

in Journal of Materials Science (2002), 37

In this work, an evaluation method to calculate the austenite fraction during continuous heating and isothermal annealing from dilatometric data is proposed. By means of a single reference measurement to ... [more ▼]

In this work, an evaluation method to calculate the austenite fraction during continuous heating and isothermal annealing from dilatometric data is proposed. By means of a single reference measurement to determine a scaling factor correcting for experimental errors, a framework is created to determine the austenite fraction as a function of time and temperature. In the evaluation of the dilatometric data the effect of the changing carbon concentration in austenite phase is taken into account. The method is applied to dilatometric data for a 0.16C-1.5Mn-0.4Si (wt%) low-silicon transformation induced plasticity (TRIP) multiphase steel. Three typical dilatometric data are obtained by heating the material to 750°C, 800°C or 900°C, which leads to three different microstructures consisting of (1) ferrite, cementite and austenite, (2) ferrite and austenite and (3) full austenite, respectively. The calculated results using the proposed new method are compared with the results from thermodynamic analysis and those from quantitative microscopic analysis. Significant inter-test discrepancies are observed. [less ▲]

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See detailHamstring muscle strain recurrence and strength performance disorders
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Namurois, Marie-Hélène ULg et al

in American Journal of Sports Medicine (2002), 30(2, Mar-Apr), 199-203

We determined the frequency of strength disorders in 26 athletes with a history of hamstring muscle injury and recurrent strains and discomfort. We also assessed the effectiveness of rehabilitation to ... [more ▼]

We determined the frequency of strength disorders in 26 athletes with a history of hamstring muscle injury and recurrent strains and discomfort. We also assessed the effectiveness of rehabilitation to correct muscle performance. After concentric and eccentric isokinetic assessment, 18 athletes were found to have strength deficits, as determined by statistically selected cutoffs of peak torque, bilateral differences, and the flexors/quadriceps ratio. The discriminating character of the eccentric trial was demonstrated, combining a preferential eccentric peak torque deficit and a significant reduction of the mixed eccentric flexors/concentric quadriceps ratio. The athletes with muscle imbalances followed a rehabilitation program individually adapted from their strength profile. Treatment length was from 10 to 30 sessions and resulted in isokinetic parameter normalization in 17 of 18 subjects. Isokinetically corrected subjects were observed for 12 months after return to athletics. None sustained a clinically diagnosed hamstring muscle reinjury. Subjective intensity of pain and discomfort were significantly reduced, and they all returned to their prior level of competition. These results demonstrate that persistent muscle strength abnormalities may give rise to recurrent hamstring injuries and discomfort. An individualized rehabilitation program emphasizing eccentric training based on specific deficits contributes to a decrease in symptoms on return to sports. [less ▲]

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See detailThe role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell
Dremier, S.; Coulonval, K.; Perpete, S. et al

in Annals of the New York Academy of Sciences (2002), 968

Cyclic AMP has been shown to inhibit cell proliferation in many cell types and to activate it in some. The latter has been recognized only lately, thanks in large part to studies on the regulation of ... [more ▼]

Cyclic AMP has been shown to inhibit cell proliferation in many cell types and to activate it in some. The latter has been recognized only lately, thanks in large part to studies on the regulation of thyroid cell proliferation in dog thyroid cells. The steps that led to this conclusion are outlined. Thyrotropin activates cyclic accumulation in thyroid cells of all the studied species and also phospholipase C in human cells. It activates directly cell proliferation in rat cell lines, dog, and human thyroid cells but not in bovine or pig cells. The action of cyclic AMP is responsible for the proliferative effect of TSH. It accounts for several human diseases: congenital hyperthyroidism, autonomous adenomas, and Graves' disease; and, by default, for hypothyroidism by TSH receptor defect. Cyclic AMP proliferative action requires the activation of protein kinase A, but this effect is not sufficient to explain it. Cyclic AMP action also requires the permissive effect of IGF-1 or insulin through their receptors, mostly as a consequence of PI3 kinase activation. The mechanism of these effects at the level of cyclin and cyclin-dependent protein kinases involves an induction of cyclin D3 by IGF-1 and the cyclic AMP-elicited generation and activation of the cyclin D3-CDK4 complex [less ▲]

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See detailCaractérisation physico-chimique de gommes végétales exsudées par quelques acacias du Burkina Faso
Djiré, O.; Ntema, P.; Zgoulli, S. et al

in Science et Technique (2002), 25(2), 37-47

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See detailPISA : une enquête en suspicion légitime
Dumortier, Jean-Louis ULg

in Lettre de la DFLM (2002), 30

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See detailUne dorsalgie malheureusement tenace
Malaise, Michel ULg; Kaye, Olivier; Radermecker, Maurice ULg et al

in Revue Médicale de Liège (2002), 57(5), 270-273

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of ... [more ▼]

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of imagery, a meticulous clinical history and physical examination remain mandatory. They will lead the exploration. Idiopathic intercostal neuralgia does not exist. [less ▲]

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See detailLa réforme de l'adoption pas à pas. Note sous C.A., 28 novembre 2001
Leleu, Yves-Henri ULg

in Journal des Tribunaux (2002)

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See detailEvaluation of ocean model ventilation with CFC-11: comparison of 13 global ocean models
Dutay, J.-C.; Bullister, J. L.; Doney, S. C. et al

in Ocean Modelling (2002), 4(2), 89-120

We compared the 13 models participating in the Ocean Carbon Model Intercomparison Project (OCMIP) with regards to their skill in matching observed distributions of CFC-11. This analysis characterizes the ... [more ▼]

We compared the 13 models participating in the Ocean Carbon Model Intercomparison Project (OCMIP) with regards to their skill in matching observed distributions of CFC-11. This analysis characterizes the abilities of these models to ventilate the ocean on timescales relevant for anthropogenic CO2 uptake. We found a large range in the modeled global inventory (+/- 30\%), mainly due to differences in ventilation from the high latitudes. In the Southern Ocean, models differ particularly in the longitudinal distribution of the CFC uptake in the intermediate water, whereas the latitudinal distribution is mainly controlled by the subgrid-scale parameterization. Models with isopycnal diffusion and eddy-induced velocity parameterization produce more realistic intermediate water ventilation. Deep and bottom water ventilation also varies substantially between the models. Models coupled to a sea-ice model systematically provide more realistic AABW formation source region; however these same models also largely overestimate AABW ventilation if no specific parameterization of brine rejection during sea-ice formation is included. In the North Pacific Ocean, all models exhibit a systematic large underestimation of the CFC uptake in the thermocline of the subtropical gyre, while no systematic difference toward the observations is found in the subpolar gyre. In the North Atlantic Ocean, the CFC uptake is globally underestimated in subsurface. In the deep ocean, all but the adjoint model, failed to produce the two recently ventilated branches observed in the North Atlantic Deep Water (NADW). Furthermore, simulated transport in the Deep Western Boundary Current (DWBC) is too sluggish in all but the isopycnal model, where it is too rapid. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailDHEA et intracrinologie de jouvence pour la peau? Entre raison et magie.
Bourguignon, Raphael; Uhoda, I.; Henry, Frédérique ULg et al

in Revue Médicale de Liège (2002), 57(7), 438-42

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In ... [more ▼]

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In the skin, sebaceous glands enlarge and seborrhoea increases in post-menopausal women. No other effect is clinically discernable on the skin. At this level, DHEA does not show efficacy comparable to that of other anti-ageing compounds. [less ▲]

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See detailPosidonia Oceanica Meadow: A Low Nutrient High Chlorophyll (LNHC) System?
Gobert, Sylvie ULg; Laumont, N.; Bouquegneau, Jean-Marie ULg

in BMC Ecology (2002), 2

BACKGROUND: In spite of very low nutrient concentrations in its vicinity - both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high biomass and productivity. We measured the ... [more ▼]

BACKGROUND: In spite of very low nutrient concentrations in its vicinity - both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high biomass and productivity. We measured the nutrient fluxes from the sediment into the water enclosed among the leaf shoots ("canopy water") to determine if it is possible source of nutrients for P. oceanica leaves. RESULTS: During the summer, the canopy water appears to act as a nutrient reservoir for the plant. During that period, the canopy water layer displays both a temperature 0.5 degrees C cooler than the upper water column, and a much higher nutrient content, as shown in this work using a very simple original technique permitting to sample water with a minimal disturbance of the water column's vertical structure.Despite low nutrient concentrations in pore water, mean net fluxes were measured from the sediment to the canopy water. These fluxes are sufficient to provide 20% of the mean daily nitrogen and phosphorus requirement of the P. oceanica shoots. CONCLUSION: An internal cycling of nutrients from P. oceanica senescent leaves was previously noted as an efficient strategy to help face low nutrient availability. The present study points out a second strategy which consists in holding back, in the canopy, the nutrients released at the water-sediment interface. This process occurs when long leaves, during poor nutrient periods in the water column, providing, to P. oceanica, the possibility to develop, high biomass, high chlorophyll quantities in low nutrient environment (a Low Nutrients High Chlorophyll system). [less ▲]

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See detailUne allergie conjugale exacerbée: les dermatoses par procuration.
Martalo, O.; Fraiture, A. L.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(5), 320-3

A young woman presented two distinct vesiculobullous dermatoses sharing in common her husband's imputability. She suffered from contact dermatitis due to colophony used by her husband who was violinist ... [more ▼]

A young woman presented two distinct vesiculobullous dermatoses sharing in common her husband's imputability. She suffered from contact dermatitis due to colophony used by her husband who was violinist. During her second pregnancy, pemphigoid gestationis was diagnosed. This autoimmune disease is directed to the father's HLA class II present on the placenta. The same antibodies also interact with the dermo-epidermal junction in the mother where they induce blisters. [less ▲]

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See detailImage analysis characterization of highly oriented freeze-drying porous materials
Blacher, Silvia ULg; Maquet, Véronique; Jérôme, Robert ULg et al

in Image Analysis and Stereology (2002), 21

Image analysis has been used as a potential tool for the characterization of the texture of ultramacroporous foams prepared by freeze-drying. It has been shown that this technique actually provides ... [more ▼]

Image analysis has been used as a potential tool for the characterization of the texture of ultramacroporous foams prepared by freeze-drying. It has been shown that this technique actually provides valuable information on the structure of this kind of material. Image analysis of SEM micrographs of transverse sections at two different magnifications gave information on both the macroporosity (10 μm < width < 100 μm) and ultramacroporosity (width > 100 μm). Moreover, the foam anisotropy has been determined by image analysis of longitudinal sections. [less ▲]

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See detailIn vitro culture of immature embryos of Phaseolus polyanthus Greenm. and Phaseolus vulgaris L.
Toussaint, André ULg; Clément, F.; Mergeai, Guy ULg et al

in Annual Report of the Bean Improvment Cooperative (2002), 45

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See detailComment on "Strong vortex liquid correlation from multiterminal measurements on untwinned YBa2Cu3O7-delta single crystals"
Maiorov, B.; Silhanek, Alejandro ULg; de la Cruz, F. et al

in Physical Review Letters (2002), 88(13),

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See detailIsolement et caractérisation de l'ostéocalcine équine
Carstanjen, Bianca; Wattiez, R.; Amory, Hélène ULg et al

in Annales de Médecine Vétérinaire (2002), 146

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the ... [more ▼]

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the purification procedure was based on reverse phase chromatography, gel filtration and ion exchange chromatography. The amino acid sequence of the primary structure has been determined to be YLDHWLGA(HYP) APYPDPL(GLA)PRR(GLA)VC (GLA)LNPDCDELADHIGF-AYRRFYGPV. The protein has a calculated molecular weight of 5,732 kDa and a calculated isoelectric point of 4,45. It contains 49 amino acids, from which 3 are gamma-carboxyglutamic acid residues at position 17, 21 and 24 and has a fully hydroxylated proline in position nine and cysteine in position 23 and 29. Equine osteocalcin shows a strong homology with bovine (98%), ovine (96%) and human (94%) osteocalcin [less ▲]

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See detailExercise-induced pulmonary perfusion redistribution in heaves
Harmegnies, N. F.; Duvivier, D. H.; Vandenput, Sandrina ULg et al

in Equine Veterinary Journal. Supplement (2002), 34(suppl), 478-484

This study aimed to compare exercise-induced pulmonary perfusion redistribution in healthy vs. 'heavey' horses using scintigraphy, a minimally invasive technique. Six healthy (A) and 5 'heavey' horses in ... [more ▼]

This study aimed to compare exercise-induced pulmonary perfusion redistribution in healthy vs. 'heavey' horses using scintigraphy, a minimally invasive technique. Six healthy (A) and 5 'heavey' horses in remission (B(I)) and during clinical signs of disease (B(II)) were investigated. Dimensions of the exercising pulmonary perfusion (QE) images were expressed in percent of the resting perfusion (QR) images. Computed QE to QR ratios (QE/QR) images enabled the definition of the region more perfused at exercise than at rest (R1). In all groups, exercise induced a major enlargement of the Q image but a larger increase of the lung height was found in 'heavey' horses. Compared to A, 'heavey' horses showed a larger R1 region with a significantly higher QE/QR. Location of R1 pointed out the dorsal lung region as a major site of pulmonary perfusion redistribution for all groups. This work demonstrated (1) the feasibility of using scintigraphy for studying exercise-induced pulmonary perfusion redistribution; (2) perfusion redistribution to the dorsal lung with exercise and (3) an intensified redistribution in 'heavey' horses, either clinically affected or not. [less ▲]

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See detailSyndrome du canal lent associe a une translocation autosomique 2q31-9p27.
Zeevaert, Bernard ULg; Hansen, Isabelle ULg; Crielaard, Jean-Michel ULg et al

in Revue Neurologique (2002), 158(5 Pt 1), 605-8

A 27-year-old man complained of cervicoscapular and forearm weakness and amyotrophy. Electromyographic evaluation showed neuromuscular transmission dysfunction and a repetitive compound muscle action ... [more ▼]

A 27-year-old man complained of cervicoscapular and forearm weakness and amyotrophy. Electromyographic evaluation showed neuromuscular transmission dysfunction and a repetitive compound muscle action potential to a single stimulus. Prostigmine did not improve neuromuscular transmission. The genetic analysis of the patient's lymphocytes demonstrated a chromosomic 2q31-9p27 translocation. The combination of the clinical and electrophysiological data as well as the lack of auto-immunity signs against neuromuscular junction constituents led to the diagnosis to congenital postsynaptic myasthenic syndrome also called slow channel syndrome. This congenital myasthenic syndrome is for the first time associated with an autosomal translocation 2q31-9p27. [less ▲]

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See detailAcarbose for type 2 diabetes prevention.
Scheen, André ULg

in Lancet (2002), 360(9344), 15161517

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See detailDe la débrouillardise à la recherche active... Réflexions sur une expérience pédagogique.
Guillaume, Jean-François ULg; Xhonneux, Michel ULg

in L'Ecole Valdôtaine. Cahier pédagogique (2002), 57

Présentation d'un dispositif d'apprentissage axé sur la résolution de situations-problèmes visant à confronter des jeunes parvenus en fin de scolarité obligatoire aux institutions, aux organismes et/ou ... [more ▼]

Présentation d'un dispositif d'apprentissage axé sur la résolution de situations-problèmes visant à confronter des jeunes parvenus en fin de scolarité obligatoire aux institutions, aux organismes et/ou aux services actifs dans le domaine de la protection sociale et de l'aide sociale. [less ▲]

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See detailLe roman poétique en 1929. Nord, entre fantastique réel et réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 31-40

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See detailLes troubles morpho-syntaxiques développementaux en langage oral : quel cadre théorique adopter?
Maillart, Christelle ULg; Schelstraete, Marie-Anne; Hupet, Michel

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2002), 37(2), 85-102

This article contrasts two theoretical frames actually used to account for morphosyntactic disorders in children with specific language impairment. The first one stems from a traditional formal linguistic ... [more ▼]

This article contrasts two theoretical frames actually used to account for morphosyntactic disorders in children with specific language impairment. The first one stems from a traditional formal linguistic account developped in the context of Chomsky’s works while the second approach, the emergent account, is more functional. Following the linguistic account, it has been assumed that children are born with an innate set of representational constraints, the Universal Grammar, on which grammars are possible for a given language. In contrast, for the emergentist view, it is not necessary to postulate an autonomous device that evolved for grammar rather language in general, and grammar in particular, would emerge from cognitive and communicative abilities and linguistic environment. Both theoretical frames are briefly presented and discussed as well as their implications for the pathology study in children. [less ▲]

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See detailImportance et dispersion de la maladie du hêtre en Région wallonne. Premier résultats d'un inventaire spécifique
Rondeux, Jacques ULg; Bourland, Nils ULg; Huart, O. et al

in Silva Belgica (2002), 109(3), 22-30

Suite aux attaques massives de scolytes sur les hêtres de Gaume et surtout d'Ardenne au printemps 2001, un inventaire spécifique a été mené dans les hêtraies publiques de Wallonie. Les auteurs se ... [more ▼]

Suite aux attaques massives de scolytes sur les hêtres de Gaume et surtout d'Ardenne au printemps 2001, un inventaire spécifique a été mené dans les hêtraies publiques de Wallonie. Les auteurs se proposent de vous présenter une première analyse des résultats. [less ▲]

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See detailComment je traite ... le pied du sportif et sa pathologie cutanée non mycosique
Goffin, Véronique ULg; Bourguignon, R.; Fraiture, A. L. et al

in Revue Médicale de Liège (2002), 57(10), 630-6

Skin and nails of the foot of sport practitioners of various disciplines are subjected to the effects of benign but invalidating pathologies. Microtraumatisms are frequently involved. Beside ... [more ▼]

Skin and nails of the foot of sport practitioners of various disciplines are subjected to the effects of benign but invalidating pathologies. Microtraumatisms are frequently involved. Beside dermatomycoses and onychomycoses, a dozen of typical disorders are identified. [less ▲]

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See detailA quinze ans, trop de jeunes sont brouillés avec la lecture
Lafontaine, Dominique ULg

in Caractères (2002), 7

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See detailSplit face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.
Uhoda, Isabelle; Faska, Najat; Robert, Caroline et al

in Skin Research & Technology (2002), 8(3), 164-7

BACKGROUND/AIMS: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel ... [more ▼]

BACKGROUND/AIMS: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. METHODS: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. RESULTS: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. CONCLUSION: The DMAE formulation under investigation increased skin firmness. [less ▲]

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See detailModélisation de l’impact de mollusques filtreurs sur le phytoplancton de la Moselle.
Descy, Jean-Pierre; Everbecq, Etienne ULg; Gosselain, Véronique ULg et al

in Tribune de l'Eau (La) (2002), 55-56(n° 619-620), 130-138

Le modèle POTAMON (Everbecq & al., 2001) a été utilisé pour simuler l'effet de mollusques bivalves (principalement Dreissena polymorpha) sur le phytoplancton et le zooplancton d'une rivière de plaine, la ... [more ▼]

Le modèle POTAMON (Everbecq & al., 2001) a été utilisé pour simuler l'effet de mollusques bivalves (principalement Dreissena polymorpha) sur le phytoplancton et le zooplancton d'une rivière de plaine, la Moselle. Les simulations suggèrent un impact significatif des mollusques filtreurs sur le phytoplancton, en particulier en été. Les simulations ont également permis d'établir un bilan carbone de la rivière et d'expliquer les déficits en oxygène observés dans la Moselle. [less ▲]

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See detailStreamlining cosmetology by standardized testing?
Pierard, Gérald ULg

in Journal of Cosmetic Dermatology (2002), 1(2), 97-898

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See detailElectronic structure of thallium filled skutterudites studied by x-ray absorption and Mossbauer spectroscopy
Long, G. J.; Mahieu, B.; Sales, B. C. et al

in Journal of Applied Physics (2002), 92(12), 7236-7241

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4 ... [more ▼]

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4-yFeySb12 and TlxCo4Sb12-zSnz compounds with a range of x, y, and z values. The thallium L-III-edge x-ray absorption spectra are independent of x, y, and z and are well reproduced by full multiple scattering calculations with a cluster with a radius of 8.5 Angstrom centered on thallium. The iron-57 Mossbauer spectra consist of two doublets and the major component is assigned to iron on the cobalt sublattice in view of its hyperfine parameters. The origin of the minor component is uncertain and is tentatively assigned to either iron with thallium vacancies as next nearest neighbors or to iron in the voids. The tin-119 Mossbauer spectral hyperfine parameters clearly indicate that tin substitutes for antimony in the skutterudite structure. Further, the tin electronic configuration is very similar to that of antimony and is insensitive to the thallium content. (C) 2002 American Institute of Physics. [less ▲]

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See detailRegelgeving inzake het zelfbeschikkingsrecht, Redactie Privaat
Leleu, Yves-Henri ULg

in Tijdschrift voor Privaatrecht (2002)

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See detailCurrent treatments of muco-cutaneous herpes simplex virus infections
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Current Medicinal Chemistry - Anti-Infective Agents (2002), 1(1), 83-98

Infection by Herpes Simplex Virus (HSV) types I and II represent a worldwide medical problem. After the primary infection the virus establishes a life-long latency in the dorsal root ganglia and ... [more ▼]

Infection by Herpes Simplex Virus (HSV) types I and II represent a worldwide medical problem. After the primary infection the virus establishes a life-long latency in the dorsal root ganglia and recurrences may occur at unpredictable times and rate. The most frequent clinical presentation of HSV infection is recurrent herpes labialis and herpes genitalis. The clinical expression varies according to the body site, the infected cell type, the relationship between HSV and the host immune status. Viral identification techniques such as immunohistochemistry and in situ hybridization on Tzanck smears and muco-cutanenous biopsies are helpful in the diagnosis of atypical cutaneous lesions. The treatment modalities of HSV infections include the reduction of viral load using antiviral agents, the non-specific immune stimulation of the host and specific vaccination in order to prevent new acquisition and to mitigate symptoms in already infected individuals. This review addresses various therapeutic options, their mode of action, and clinical value as well as the indications of the various drugs. [less ▲]

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See detailSwaged bolts: modelling of the installation process and numerical analysis of the mechanical behaviour
Drean, M.; Habraken, Anne ULg; Bouchaïr, A. et al

in Computers & Structures (2002), 80

Swaged bolts are an alternative to high strength bolts in steel structures. To clarify the steps of the installation process, numerical modelling has been carried out. The relevant phenomena are described ... [more ▼]

Swaged bolts are an alternative to high strength bolts in steel structures. To clarify the steps of the installation process, numerical modelling has been carried out. The relevant phenomena are described and evaluated. This numerical calculation accounts for large displacements, large strains, mechanical plasticity and friction contact between the components of swaged bolts. The non-linear finite element code ‘‘Lagamine’’ designed for the simulation of metal forming processes has been used to provide the stress distributions in the components. [less ▲]

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See detailInhibition Of Histone Deacetylases Induces Bovine Leukemia Virus Expression In Vitro And In Vivo
Merezak, C.; Reichert, M.; Van Lint, C. et al

in Journal of Virology (2002), 76(10),

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See detailThe gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man
Marion, Evelyne; Kaisaki, Pamela Jane; Pouillon, Valérie et al

in Diabetes (2002), 51

Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and ... [more ▼]

Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report the presence of SHIP2 gene mutations associated with type 2 diabetes in rats and humans. The R1142C mutation specifically identified in Goto-Kakizaki (GK) and spontaneously hypertensive rat strains disrupts a potential class II ligand for Src homology (SH)-3 domain and slightly impairs insulin signaling in cell culture. In humans, a deletion identified in the SHIP2 3' untranslated region (UTR) of type 2 diabetic subjects includes a motif implicated in the control of protein synthesis. In cell culture, the deletion results in reporter messenger RNA and protein overexpression. Finally, genotyping of a cohort of type 2 diabetic and control subjects showed a significant association between the deletion and type 2 diabetes. Altogether, our results show that mutations in the SHIP2 gene contribute to the genetic susceptibility to type 2 diabetes in rats and humans [less ▲]

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See detailSclérodermie monomélique et alcipotriol topique.
Paquet, Philippe ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2002), 70

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See detailSynthesis of peptide-modified pyoverdins by a fluorescent Pseudomonas strain grown in isoleucine-supplemented medium
Ongena, MARC ULg; Jacques, Philippe ULg; De Pauw, Edwin ULg et al

in Letters in Peptide Science (2002), 8(1), 21-27

The pattern of pyoverdin-type siderophores produced by Pseudomonas putida BTP16 in iron-limited succinate medium supplemented or not with isoleucine was characterized by electrospray ionization mass ... [more ▼]

The pattern of pyoverdin-type siderophores produced by Pseudomonas putida BTP16 in iron-limited succinate medium supplemented or not with isoleucine was characterized by electrospray ionization mass spectrometry. Two new compounds were observed in culture supernatants from BTP16 grown in the presence of isoleucine. For both molecules, mass differences with pyoverdins originally synthesized by the strain were only interpreted considering the incorporation of Ile into the peptide chain. Further evidence supporting this phenomenon was provided by radioactivity incorporation in pyoverdins produced in the presence of C-14-labeled Ile. Our results are discussed in relation to the non-ribosomal mechanism supposed to be involved in the synthesis of these molecules. [less ▲]

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See detailEffects of lesions of nucleus taeniae on appetitive and consummatory aspects of male sexual behavior in Japanese quail
Absil, Philippe ULg; Braquenier, Jean-Baptiste ULg; Balthazart, Jacques ULg et al

in Brain, Behavior & Evolution (2002), 60(1), 13-35

Neurochemical, hodological and functional criteria suggest that the nucleus taeniae and parts of the adjacent archistriatum represent the avian homologue of parts of the mammalian amygdaloid complex. It ... [more ▼]

Neurochemical, hodological and functional criteria suggest that the nucleus taeniae and parts of the adjacent archistriatum represent the avian homologue of parts of the mammalian amygdaloid complex. It has been proposed in particular that the nucleus taeniae is the homologue of the mammalian medial amygdala. In male quail, relatively large lesions to the posterior/medial archistriatum selectively decrease the expression of appetitive sexual behavior in a manner reminiscent of similar manipulations involving the medial amygdala in mammals. We investigated the effects of discrete lesions restricted to nucleus taeniae and of lesions to an adjacent part of the archistriaturn (pars intermedium ventralis, Alv) on the expression of appetitive (ASB) and consummatory (CSB) aspects of male sexual behavior. ASB was measured by a learned social proximity response (after copulation a male quail stands in front of a window providing visual access to a female) and by the frequency of rhythmic cloacal sphincter movements. CSB was assessed by the frequency of mount attempts (MA) and cloacal contact movements (CCM). Lesions confined to nucleus taeniae and to Alv did not influence the acquisition or the maintenance of the two responses indicative of ASB. In contrast, lesions of nucleus taeniae significantly increased the occurrence frequencies of MA and CCM when administered before the beginning of behavior testing and increased the frequency of MA only when performed on sexually experienced subjects. No effect of Alv lesions could be detected. The discrepancy between these results and previous experiments in quail might reflect procedural differences, but more probably differences in locations of the lesions that were restricted in the current study to the anterior part of taeniae. Those in the Thompson study were in the posterior part of this nucleus. These findings indicate that there is a larger degree of functional heterogeneity in the nucleus taeniae than previously thought. The effects of taeniae lesions suggest that this nucleus, similar to the medial amygdala in mammals, might be implicated in the control of sexual satiety. Copyright (C) 2002 S. Karger AG, Basel. [less ▲]

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See detailPour une sémiologie historique de l'acte photographique
Havelange, Carl ULg

in Revue de la Faculté des Lettres d'El Jadida (2002)

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See detailNationalisme et Démocratie
Martiniello, Marco ULg; Beaufays, Jean ULg

in Fédéralisme - Régionalisme (2002)

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See detailNormative and psychometric data from the Body Image Assessment - Revised in a population of french-speaking women
Bragard, Isabelle ULg; Mayers, I.; Demoulin, Catherine et al

in Psychologica Belgica (2002), 42(4), 227-249

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female ... [more ▼]

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female subjects. They completed questionnaires assessing body experience, eating pathology, psychological functioning, general perception and the BIA-R (Beebe et al., 1999). This test consists of nine silhouettes from which the subject has to choose the somatotype corresponding to her actual shape (cognitive response), the way she feels (affective response) and the way she would like to look (optative response). The results show a good concurrent validity for the cognitive and affective indices and the affective/ cognitive vs. optative divergences. On the other hand, we were not able to demonstrate such validity for the optative index and the affective vs. cognitive divergence index [less ▲]

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See detailFast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
Lemaire, Christian ULg; Damhaut, P.; Lauricella, Benjamino ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2002), 45(5), 435-447

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose ... [more ▼]

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose compound ([18F]TAG). After radiolabelling, this derivative was trapped on a solid phase extraction (SPE) cartridge and the residual reaction solvent (CH3CN), reagents (K222, K2CO3,) and by-products removed by washing the support with water. After this cleaning step, the acetyl groups were cleaved on the same tC18 column using 2N sodium hydroxide. This fast reaction proceeded near quantitatively (>98%) at room temperature in less than 2 min. The [18F]FDG was then recovered with a small amount of water, neutralized with a slight excess of 2N hydrochloric acid, buffered for pH with a citrate solution and finally purified on a neutral alumina oxide and a second tC18 column. After filtration, the radiochemical yield of this [18F]FDG isotonic solution after more than 100 production runs was found to be very reliable and reproducible (70±6% decay corrected). The synthesis time was about 22 min. Quality controls showed that the radiochemical purity was higher than 98% and in any case no [18F]FDM was detected. Only traces of 2-chloro-2-deoxy-glucose (ClDG) were found in the final sample (64±9 g/ batch of 16 ml). [18F]FDG specific activity averaged between 1 and 20 Ci/µmol (EOS). No evaporation and use of ion retardation resin (AG11A8) are required. Moreover, this new approach is suitable for complete remote operation using available single use medical components. Copyright © 2002 John Wiley [less ▲]

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See detailPetite réflexion sur la qualité du bois d'épicéa
Hebert, Jacques ULg; Herman, Marc; Jourez, Benoît ULg

in Forêt Wallonne (2002), (60), 24-25

En termes de qualité du bois, l'influence du sylviculteur est déterminante. En effet, dès la décision de plantation, et ensuite, par le jeu des soins culturaux et des éclaircies, il va façonner, compte ... [more ▼]

En termes de qualité du bois, l'influence du sylviculteur est déterminante. En effet, dès la décision de plantation, et ensuite, par le jeu des soins culturaux et des éclaircies, il va façonner, compte tenu des conditions environnementales, les caractéristiques de la matière première qui en définiront les aptitudes technologiques. [less ▲]

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See detailInfo-congres. Essai de prevention du diabete de type 1 par le nicotinamide: les lecons positives d'un essai clinique negatif (ENDIT).
Philips, Jean-Christophe ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(10), 672-5

ENDIT ("European Nicotinamide Diabetes Intervention Trial") is a large placebo-controlled randomised clinical trial that aimed at studying the efficacy of nicotinamide in the prevention of type 1 diabetes ... [more ▼]

ENDIT ("European Nicotinamide Diabetes Intervention Trial") is a large placebo-controlled randomised clinical trial that aimed at studying the efficacy of nicotinamide in the prevention of type 1 diabetes mellitus among first-degree relatives of type 1 diabetic patients with positive islet cell antibodies (ICA). The results presented at the last congress of the European Association for the Study of Diabetes (EASD) in Budapest do not evidence any significant difference in the risk of developing overt diabetes mellitus in the patients treated with nicotinamide (n = 274) as compared to those receiving placebo (n = 275) after 5 years of follow-up. Despite these negative results, positive lessons could be drawn from ENDIT: 1) the feasibility of a large long-standing multicentre European trial in a difficult research area; 2) the importance of large randomised controlled clinical trials to bring the evidence requested by "Evidence-Based Medicine"; 3) the predictive value of various risk markers to progress toward type 1 diabetes in first-degree relatives, especially the number of positive auto-antibodies; and 4) the urgent need to continue intensive research in this important field of preventive medicine. [less ▲]

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See detailInteraction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane.
Aguedo, Mario ULg; Beney, Laurent; Wache, Yves et al

in International journal of food microbiology (2002), 80(3), 211-5

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological ... [more ▼]

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. Gamma-decalactone was previously shown to have antimicrobial properties. We determined by infrared spectroscopy measurements that this compound rapidly diffused into model phospholipid bilayers (within 2 min), modifying the general physical state of a dimyristoyl-L-alpha-phosphatidylcholine (DMPC) film. In vivo, the lactone strongly increased membrane fluidity in the model yeast Yarrowia lipolytica, as evaluated by fluorescence anisotropy measurements. This effect was more important than that of benzyl alcohol, which is known as a fluidizing agent in living cells, and may explain the toxic action of gamma-decalactone in microorganisms. [less ▲]

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See detailAcamprosate reduces context-dependent ethanol effects
Quertemont, Etienne ULg; Brabant, Christian ULg; De Witte, Philippe

in Psychopharmacology (2002), 164(1), 10-18

Rationale: Previous studies have indicated that the conditioned effects of environmental stimuli contribute to ethanol tolerance and abuse. Acamprosate was recently suggested to reduce the effects of ... [more ▼]

Rationale: Previous studies have indicated that the conditioned effects of environmental stimuli contribute to ethanol tolerance and abuse. Acamprosate was recently suggested to reduce the effects of environmental stimuli previously associated with ethanol administrations. This action is believed to contribute to the clinical benefits of acamprosate treatment in alcoholics. Objectives: In the present experiment, a classical drug-conditioning paradigm was used to test whether acamprosate modulates the effects of ethanol-paired environmental stimuli on spontaneous motor activity. Methods: Wistar rats were divided into three groups: cued, uncued and control. The cued group daily received ethanol injections (2.0 g/kg, IP) in a specific testing environment. The uncued group daily received ethanol injections (2.0 g/kg, IP) in their home cage but never experienced ethanol in the testing environment. The control group was injected with saline and never experienced ethanol. After 8 conditioning days, the rats were IP injected with various ethanol doses (saline, 1.0, 1.5 or 2.0 g/kg) and their spontaneous motor activity in the testing environment was recorded to investigate their respective tolerance to ethanol inhibitory effects. In the second part of the study, the same procedure was repeated with chronically acamprosate-treated rats. The chronic acamprosate treatment (400 mg/kg per day) started 2 weeks before the conditioning procedure by diluting acamprosate in the drinking bottles and was maintained throughout the whole experiment. Results: The cued rats showed a significant environment-dependent tolerance to ethanol inhibitory effects relative to the uncued and control rats. This higher ethanol tolerance of the cued rats was mainly due to a faster recovery from ethanol's inhibitory effects on spontaneous activity. Furthermore, the cued rats showed a higher level of activity in the testing environment after the saline injection. However, it is not clear whether this hyperactivity is a conditioned compensatory response or an increased exploratory behavior. Acamprosate totally abolished the environment-dependent tolerance to ethanol, whereas it did not alter the hyperactivity of the cued rats in the testing environment. Conclusions: The results of the present study suggest that acamprosate reduces ethanol-conditioned effects. Such an action may be of importance to explain the anti-relapse effects of acamprosate. [less ▲]

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See detailLe GPS et la Physique
Garnir, Henri-Pierre ULg; Strivay, David ULg; Bastin, Thierry ULg

in Science and Culture (2002), 380

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See detailAortofemorographie par resonance magnetique nucleaire versus arteriographie conventionnelle: evaluation prospective.
NCHIMI LONGANG, Alain ULg; Brisbois, D.; Donkers, E. et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2002), 85(5), 246-51

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively ... [more ▼]

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively compared to DSA in 49 consecutive patients (40 males, 9 females; age range 38-80 years; mean age 64 years). According to Leriche and Fontaine's clinical gradation of lower limb ischemia, 5 patients were graded I, 37 graded II, 4 graded III, and 3 graded IV. Two observers graded stenoses for DSA and three for MRA. Cohen's kappa statistics were used to evaluate interobserver variability using MRA, as well as to compare MRA to DSA. In addition, sensitivity, specificity, positive and negative predictive values of MRA for the assessment of stenosis superior to 80% were calculated by using DSA as a gold standard, respectively for arterial trunks above and below the level of the knees. RESULTS: Overall accuracy of MRA was 92%. Comparison of DSA and MRA yielded a kappa value of 0.87 (0.95 for arterial trunks located above the level of the knees and 0.75 below). Interobserver agreement was very good. Sensitivity, specificity, positive and negative predictive values of MRA for the diagnosis of > 80% stenosis were respectively 98, 98, 85 and 99% above the level of the knees and 87, 91, 77 and 96% below the knees. CONCLUSION: MRA can be considered as valuable technique for the evaluation of peripheral arterial obstructive disease, especially for stenosis located above the level of the knees. [less ▲]

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See detailLes herpèsviroses des petits ruminants
Thiry, Etienne ULg; Keuser, Véronique; Tempesta, Maria

in Point Vétérinaire (2002), 33(74-76),

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See detailThe Otherness of Self. A Genealogy of the Self in Contemporary China
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (2002), Volume XIV

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See detailL'exploitation du clearing à des fins de blanchiment - Pistes de réflexion
Dantinne, Michaël ULg

in Agon (2002), (36), 20-26

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See detailL'organisation au regard de l'esthétique
Servais, Christine ULg; Heller, Thomas

in Recherches en Communication (2002), 17

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See detailSex control and sex determinism study in Eurasian perch, Perca fluviatilis, by use of hormonally sex-reversed male breeders
Rougeot, Carole ULg; Jacobs, Bruno; Kestemont, Patrick et al

in Aquaculture (2002), 121

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See detailStress écologique et chronobiologique de la dérive géoclimatique.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (2002), 59

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See detailUpdate on the histological presentation of facial wrinkles.
Pierard, Gérald ULg; Uhoda, Isabelle; Pierard, Claudine ULg

in European Journal of Dermatology (2002), 12(6), -

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See detailBriefe an Goethe. Gesamtausgabe in Regestform. Bd. 6.1 und 6.2 (Rezension)
Viehöver, Vera ULg

in Germanistik (2002), 43(3/4), 5288

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See detailConjuguer les spécificités de la démarche géographique avec un enseignement centré sur les compétences. L’expérience de la FEGEPRO
Merenne-Schoumaker, Bernadette ULg

in Puzzle (2002), (11), 27-30

Presentation of the experience made by the Federation of Professors of Geography of the French Community of Belgium (FEGEPRO) to assist in the establishment of a teaching competency

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See detailUnusual traits of the pyoverdin-mediated iron acquisition system in Pseudomonas putida strain BTP1.
Ongena, MARC ULg; Jacques, Philippe ULg; Delfosse, Philippe et al

in Biometals (2002), 15(1), 1-13

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin ... [more ▼]

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin, Pseudomonas putida strain BTP1 could represent a valuable tool in an attempt to correlate the structural features of these compounds with some specificity in their two main properties i.e. affinity for iron and recognition rate by other Pseudomonas strains. An uncommonly high affinity for iron of the pyoverdin synthetized by P. putida BTP1 was observed by comparing both the apparent stability constant and the decomplexation kinetic of its ferric complex with those of ferripyoverdins from other strains. On another hand, results from growth stimulation experiments and labeled ferripyoverdin uptake assays highlighted the very low recognition rate of BTP1 isopyoverdins by membrane receptors of foreign strains. By contrast, P. putida BTP1 was able to utilize a broad spectrum of structurally unrelated exogenous pyoverdins by means of multiple receptors that are likely constitutively expressed in its outer membrane. The unusual traits of its pyoverdin-mediated iron acquisition system should contribute to enlarge the ecological competence of Pseudomonas putida BTP1 in terms of colonization and persistence in the rhizosphere. [less ▲]

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See detailPotential influence of pregnancy hormones and proteins synthesized during pregnancy on the maternal immunological status
Melo de Sousa, Noelita ULg; Figueiredo, J. R.; El Amiri, Bouchra et al

in Annales de Médecine Vétérinaire (2002), 146(2), 71-82

During pregnancy, the endocrine function of the gonads and the foeto-placental unit involves the synthesis of several hormones (progesterone, oestrogens, cortisol, prostaglandins, prolactin, chorionic ... [more ▼]

During pregnancy, the endocrine function of the gonads and the foeto-placental unit involves the synthesis of several hormones (progesterone, oestrogens, cortisol, prostaglandins, prolactin, chorionic gonadotropin, placental lactogen, also designed "chorionic somatomammotropin", etc.), and a series of growth factors and proteins. Some proteins and glycoproteins synthesized during gestation interfere with the establishment of pregnancy, corpus luteum maintenance, intermediate maternal metabolism, fetal growth, mammary growth and immunotolerance of the conceptus by the mother. This review includes a presentation of the main pregnancy-related hormones and proteins and their hypothetical role on the immunological status of the mother. [less ▲]

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See detailEntre dermatoses et entéropathies.
Quatresooz, Pascale ULg; Bourguignon, R.; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(8), 528-34

A series of gastro-intestinal diseases exhibits some connection with various cutaneous lesions. Some skin manifestations are clinically or histologically evocative, while others lack specificity. These ... [more ▼]

A series of gastro-intestinal diseases exhibits some connection with various cutaneous lesions. Some skin manifestations are clinically or histologically evocative, while others lack specificity. These manifestations can occur in overt digestive disease or be the clue for a silent one. A careful skin examination can thus reveal some inflammatory or neoplastic diseases of the gastro-intestinal tract, a malabsorption syndrome or food intolerance. [less ▲]

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See detailRate coefficient determination in charge transfer reactions
Vaeck, Nathalie; Baloïtcha, Ezinvy; Desouter, Michèle ULg et al

in International Journal of Molecular Sciences (2002), 3

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See detailRezension zu Barbara Beßlich: Wege in den ‘Kulturkrieg’
Pontzen, Alexandra ULg

in Zeitschrift für Deutsche Philologie (2002), (3), 303307

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See detailFactor XIII a-positive dermal dendrocytes and shear wave propagation in human skin.
Hermanns-Lê, Trinh ULg; Uhoda, I.; Pierard, Claudine ULg et al

in European Journal of Clinical Investigation (2002), 32(11), 847-51

BACKGROUND: The in vivo interdependence between the phenotypic characteristics of dermal cells and the strain imposed on the tissue has not been studied thoroughly in humans. In particular the mechanical ... [more ▼]

BACKGROUND: The in vivo interdependence between the phenotypic characteristics of dermal cells and the strain imposed on the tissue has not been studied thoroughly in humans. In particular the mechanical force modulation of Factor XIII a expression in dermal dendrocytes (DD) remains unknown. MATERIALS AND METHODS: The present study compares the numerical density of Factor XIII a-positive DD and the in vivo shear wave velocity in the skin. The investigation was performed in 20 men of normal weight and 20 obese men before and after entering a slimming process. RESULTS: Excess cutaneous fat places the skin under increased intrinsic tension. The resonance running time measurement (RRTM) and the DD density were significantly reduced in overweight individuals. After a short-term but intense slimming process, the same individuals showed a trend to normalization of these two parameters without, however, reaching significance. Pooling all data yielded a significant logarithmic correlation between RRTM values and densities in Factor XIII a-positive DD. CONCLUSION: Factor XIII a expression in human DD may be partially regulated by the intrinsic resting tensions in the skin. [less ▲]

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See detailA case of hepatic alveolar echinococcosis contracted in Belgium
Delbecque, Katty ULg; Detry, Olivier ULg; Hayette, Marie-Pierre ULg et al

in Acta Gastro-Enterologica Belgica (2002), 65(1, Jan-Mar), 55-60

We report herein the case of a Belgian 76-year-oId woman who developed a hepatic tumour suspected to be a breast cancer metastasis. Radiological imaging and guided biopsies were not contributive. The ... [more ▼]

We report herein the case of a Belgian 76-year-oId woman who developed a hepatic tumour suspected to be a breast cancer metastasis. Radiological imaging and guided biopsies were not contributive. The patient underwent an explorative laparoscopy with frozen sections that did not provide further diagnosis, and an open left bisegmentectomy was performed during the same anaesthesia. Histopathological examination of the hepatic mass showed Echinococcus multilocularis metacestodes, demonstrating alveolar echinococcosis. As our patient denied any travel in foreign countries and has undergone regular abdominal ultrasonographies since her mastectomy, it is highly likely that this alveolar echinococcosis had been contracted in Belgium. If some imported cases may be seldom managed in Belgium, to our knowledge, this case is the first occurrence of alveolar echinococcosis contracted in Belgium. This report, added to the demonstration of E. multilocaris infection of 50% of red foxes in Southern Belgium, and the potential infection of domestic cats and dogs, should attract attention of the medical community on the possible outbreak of endemic alveolar echinococcosis in Belgium, and on the related public health concerns. [less ▲]

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See detailLa prescription des pensions alimentaires: fin d'une controverse. Note sous Cass., 8 décembre 2000
Kohl, Benoît ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2002)

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See detailImplications pour la communauté d'un meilleur contrôle de la pression artérielle
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (2002), 14(5), 186-190

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See detailImage du mois. Une tumeur préauriculaire.
Tassoudji, Nazli ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(2), 65-66

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See detailLa précession du plan d'oscillation du pendule de Foucault : une approche géométrique intuitive
De Rop, Yves ULg; Moreau, Olivier

in Revue des Questions Scientifiques (2002), 173(3), 261-276

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See detailA. Gacek: The Arabic manuscript tradition: A glossary of technical terms and bibliography
Bauden, Frédéric ULg

in Journal of the American Oriental Society (2002), 122(3), 658-659

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See detailMulticollinearity in prognostic factor analyses using the EORTC QLQ-C30: identification and impact on model selection
Van Steen, Kristel ULg; Curran, D.; Kramer, J. et al

in Statistics in Medicine (2002), 21(24), 3865-3884

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to ... [more ▼]

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to chemotherapy. For response, different final multivariate models were obtained from forward and backward selection methods, suggesting a disconcerting instability. Quality of life was measured using the EORTC QLQ-C30 questionnaire completed by patients. Subscales on the questionnaire are known to be highly correlated, and therefore it was hypothesized that multicollinearity contributed to model instability. A correlation matrix indicated that global QL was highly correlated with 7 out of 11 variables. In a first attempt to explore multicollinearity, we used global QL as dependent variable in a regression model with other QL subscales as predictors. Afterwards, standard diagnostic tests for multicollinearity were performed. An exploratory principal components analysis and factor analysis of the QL subscales identified at most three important components and indicated that inclusion of global QL made minimal difference to the loadings on each component. suggesting that it is redundant in the model, In a second approach, we advocate a bootstrap technique to assess the stability of the models. Based on these analyses and since global QL exacerbates problems of multicollinearity, we therefore recommend that global QL be excluded from prognostic factor analyses using the QLQ-C30. The prognostic factor analysis was rerun without global QL in the model, and selected the same significant prognostic factors as before. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailL'égalité et le droit commercial: un rapport à géométrie variable
Thirion, Nicolas ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

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See detailIdentification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal.
Braem, Caroline V; Kas, Koen; Meyen, Eva et al

in Journal of Biological Chemistry (2002), 277(22), 19673-8

The activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands. To gain more insight into the regulation of ... [more ▼]

The activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands. To gain more insight into the regulation of PLAG1 function, we searched for PLAG1-interacting proteins. Using the yeast two-hybrid system, we identified karyopherin alpha2 as a PLAG1-interacting protein. Physical interaction between PLAG1 and karyopherin alpha2 was confirmed by an in vitro glutathione S-transferase pull-down assay. Karyopherin alpha2 escorts proteins into the nucleus via interaction with a nuclear localization sequence (NLS) composed of short stretches of basic amino acids. Two putative NLSs were identified in PLAG1. The predicted NLS1 (KRKR) was essential for physical interaction with karyopherin alpha2 in glutathione S-transferase pull-down assay, and its mutation resulted in decreased nuclear import of PLAG1. Moreover, NLS1 was able to drive the nuclear import of the cytoplasmic protein beta-galactosidase. In contrast, predicted NLS2 of PLAG1 (KPRK) was not involved in karyopherin alpha2 binding nor in its nuclear import. The residual nuclear import of PLAG1 after mutation of the NLS1 was assigned to the zinc finger domain of PLAG1. These observations indicate that the nuclear import of PLAG1 is governed by its zinc finger domain and by NLS1, a karyopherin alpha2 recognition site. [less ▲]

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See detailCompte rendu de V. de Coorebyter, Sartre face à la phénoménologie
Cormann, Grégory ULg

in Revue Philosophique de Louvain (2002), 1-2

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See detailLe patrimoine ferroviaire en miniature
Hoffsummer, Patrick ULg

in Cahiers de l'Urbanisme (Les) (2002)

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See detailNew antiobesity agents in type 2 diabetes: overview of clinical trials with sibutramine and orlistat.
Scheen, André ULg; Ernest, Philippe ULg

in Diabètes & Métabolism (2002), 28(6 Pt 1), 437-45

Besides genetic predisposition, obesity is the most important risk factor for the development of type 2 diabetes mellitus. Even modest weight reduction can improve blood glucose control in overweight ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of type 2 diabetes mellitus. Even modest weight reduction can improve blood glucose control in overweight subjects. After failure of lifestyle modifications, antiobesity drugs such as orlistat, a potent and selective inhibitor of gastric and pancreatic lipases that reduces lipid intestinal absorption, or sibutramine, a noradrenaline and 5-hydroxytryptamine reuptake inhibitor that regulates food intake, may be considered to favour weight loss and/or weight maintenance. Several placebo-controlled studies have recently demonstrated that both drugs are able to promote weight loss in obese type 2 diabetic patients treated with diet alone, sulphonylureas, metformin or insulin. The greater weight reduction as compared to placebo was associated with a significant reduction of glycated haemoglobin levels and/or of the doses of classical antihyperglycaemic agents, especially in good responders who lost at least 10% of initial body weight. In addition, vascular risk factors associated to insulin resistance were also reduced after weight loss. These antiobesity agents may also contribute to delay or prevent the progression from impaired glucose tolerance to overt type 2 diabetes in at risk obese individuals ("Xenical in the prevention of diabetes in obese subjects" trial). Large long-term prospective studies, such as the "Sibutramine cardiovascular and diabetes outcome study" should better determine the place of pharmacological anti-obesity strategy in the overall management of obese patients with impaired glucose tolerance or type 2 diabetes. [less ▲]

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See detailLa Vierge comme protectrice des Pays-Bas méridionaux dans les livrets de pèlerinage marial au XVIIe siècle
Delfosse, Annick ULg

in Revue Belge de Philologie et d'Histoire (2002), 80(4), 1225-1241

Study of the dual symbolic function assigned by the Belgian pilgrimage booklets to the Virgin Mary in the 17th Century: the miraculous Madonnas worshiped in the shrines to cure the private individual’s ... [more ▼]

Study of the dual symbolic function assigned by the Belgian pilgrimage booklets to the Virgin Mary in the 17th Century: the miraculous Madonnas worshiped in the shrines to cure the private individual’s troubles are indeed also invoked to dress the wounds of a nation mangled and manhandled by the civic wars. [less ▲]

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See detailCross Border Health Care : an Analysis of Recent ECJ Rulings
Fecher-Bourgeois, Fabienne ULg; Paulus, Aggie; Evers, Sylvia et al

in European Journal of Law and Economics (2002), 14

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See detailEcosystem model (MODECOGeL) of the Ligurian Sea revisited. Seasonal and interannual variability due to atmospheric forcing
Lacroix, Geneviève; Grégoire, Marilaure ULg

in Journal of Marine Systems (2002), 37(4), 229-258

A one-dimensional coupled hydrodynamical–biological model, MODe`le d’ECOsyste`me du G.H.E.R. et du L.O.V. (MODECOGeL), of the water column is developed and applied to the Ligurian Sea (North Western ... [more ▼]

A one-dimensional coupled hydrodynamical–biological model, MODe`le d’ECOsyste`me du G.H.E.R. et du L.O.V. (MODECOGeL), of the water column is developed and applied to the Ligurian Sea (North Western Mediterranean). It is an extended and improved version of the model presented by Lacroix and Nival [J. Mar. Syst. 16 (1998) 23]. The hydrodynamic model is a 1D version of the 3D turbulent closure G.H.E.R. model, which takes into account momentum and heat surface fluxes computed from a real meteorological data set. The ecosystem model is defined by a nitrogen cycle described by 12 biological state variables including several plankton size classes and an explicit description of the bacterial loop. One data set coming from the FRONTAL missions is used to initialise and validate the model. To assess the impact of the interannual variability of the meteorological conditions on the ecosystem dynamics, the coupled model is run with 4-year real meteorological conditions (October 1984–September 1988). The model estimated percentages of the interannual variability of the annual mean biomass of phytoplankton, zooplankton and bacteria respectively of 31.0%, 16.2% and 16.3%. The ontribution of the zooplankton related to the total plankton biomass (phytoplankton, zooplankton and bacteria) has been found to be the most sensitive to the meteorological conditions variations (21%), followed by the phytoplankton (12%) and finally, by the bacteria (5%). The model estimated percentages of interannual variability of the annual gross primary production, the annual mean f-ratio and the annual bacterial production respectively of 27.9%, 18.5% and 13.4% although the interannual variability of the real winds conditions is only of 11.3%. Due to the more windy and less sunny conditions prevailing during the years ‘‘1985–1986’’ and ‘‘1986–1987’’, the annual primary production was found higher than during the years ‘‘1984–1985’’ and ‘‘1987–1988’’. The bacterial production is always greater than the primary production, showing the importance of the bacteria in such an oligotrophic environment. On a seasonal scale, the highest interannual variability of the primary production and the f-ratio is found in spring like for the wind intensity. [less ▲]

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See detailUltrasound shear wave propagation in Caucasian hair.
Franchimont, Claudine ULg; Goffin, Véronique ULg; Uhoda, Emmanuelle ULg et al

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

Background : The aspect of hair depends on the spatial organization of the hair shafts and on their chemical, physical and structural integrity. Some genetic disorders and exogenous influences may affect ... [more ▼]

Background : The aspect of hair depends on the spatial organization of the hair shafts and on their chemical, physical and structural integrity. Some genetic disorders and exogenous influences may affect it. Aims : In vivo objective assessments are welcome in order to compare the consequences of hair damages and to assess the kinetics of the changes occurring in time after damaging or attempting to repair the hair structure. Method : Ultrasound shear wave propagation measured on hair is introduced as an objective non-invasive method with in vitro and in vivo applications. Results : With multiple measurements made on the scalp of 72 Caucasians, hair felting following damage appeared to be associated with an increase in the coefficient of variation of the shear wave velocity measurements. Maximum hydration of hair locks increased the shear wave velocity in vitro and decreased the intraindividual range of data. The relevance of the method and reproducibility of data was influenced by the experimentalist skill. Conclusion : Ultrasound shear wave propagation on hair is influenced by the physical integrity of the hair shafts and on their three-dimensional arrangement. [less ▲]

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See detailLa vaccination contre la fièvre aphteuse : perspectives
Thiry, Etienne ULg; De Clercq, K.; Saegerman, Claude ULg et al

in Bulletin des Groupements Techniques Vétérinaires (2002), 14

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See detailCryopreservation For The Elimination Of Cucumber Mosaic And Banana Streak Viruses From Banana (Musa Spp.)
Helliot, Bertrand; Panis, B.; Poumay, Y. et al

in Plant Cell Reports (2002), 20(12), 1117-1122

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See detailPathologie cutanée non infectieuse du pied chez le sportif.
Bourguignon, Raphaël; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2002), 72

En dehors du problème des mycoses cutanées, la peau et les ongles des pieds des sportifs sont le siège de diverses maladies bénignes mais qui peuvent cependant s’avérer invalidantes. Les disciplines de ... [more ▼]

En dehors du problème des mycoses cutanées, la peau et les ongles des pieds des sportifs sont le siège de diverses maladies bénignes mais qui peuvent cependant s’avérer invalidantes. Les disciplines de l’athlétisme et quelques autres sports en sont le plus souvent responsables car les microtraumatismes sont fréquemment impliqués. L’identification précise des désordres cutanés aide à prendre les mesures adéquates pour leur prévention. Les traitements sont essentiellement non-invasifs. [less ▲]

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See detailComparison of the collision-induced dissociation of duplex DNA at different collision regimes: Evidence for a multistep dissociation mechanism
Gabelica, Valérie ULg; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2002), 13(1), 91-98

The dissociation mechanism of duplex DNA has been investigated in detail by collision-induced dissociation experiments at different collision regimes. MS/MS experiments were performed either in a ... [more ▼]

The dissociation mechanism of duplex DNA has been investigated in detail by collision-induced dissociation experiments at different collision regimes. MS/MS experiments were performed either in a quadrupole collision cell (hybrid quadrupole-TOF instrument) or in a quadrupole ion trap with different activation times and energies. In addition to the noncovalent dissociation of the duplex into the single strands, other covalent bond fragmentation channels were observed. Neutral base loss from the duplex is favored by slow activation. In fast activation conditions, however, the major reaction channel is the noncovalent dissociation into single strands, which is highly entropy-favored. Fast activation regimes can favor the entropy-driven noncovalent dissociation, while in slow heating conditions the competition with enthalpy-driven covalent fragmentation can completely hinder the dissociation of the complex. We also evidence that the noncovalent dissociation of DNA duplex is a multistep process involving a progressive unzipping, preferentially at terminal positions. This is proposed to be a general feature for complexes containing a high number of contributing interactions organized at the interface of the ligands. The overall (observed) dissociation kinetics of noncovalent complexes can therefore depend on a complicated mechanism for which a single transition state description of the kinetics is too simplistic. [less ▲]

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See detailEnergy Balance Closure At Fluxnet Sites
Wilson, K.; Goldstein, A.; Falge, E. et al

in Agricultural and Forest Meteorology (2002), 113(1-4),

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See detailCompte-rendu de L. Blasucci, "Per una tipologia degli esordi nei canti danteschi"
Benzoni, Pietro ULg

in Stilistica e metrica (2002), II(2), 318-319

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See detailSkin tensile properties in patients treated for acromegaly.
Braham, Catherine; Betea, Daniela ULg; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(4), 325-9

BACKGROUND: Somatotropic effects are described in the skin. Indeed, acromegaly is in part clinically recognized by cutaneous coarsening. The actual changes in tensile properties associated with the ... [more ▼]

BACKGROUND: Somatotropic effects are described in the skin. Indeed, acromegaly is in part clinically recognized by cutaneous coarsening. The actual changes in tensile properties associated with the cutaneous manifestations are largely unknown. OBJECTIVES: To study the relationships between the skin tensile properties and the severity of acromegaly as assessed by serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). PATIENTS AND METHOD: Assessments were made in 13 patients with acromegaly treated by somatostatin agonists combined or not with surgery. A total of 39 age- and sex-matched healthy subjects served as controls. Skin tensile properties were measured on the forearm and nape of the neck using a computerized suction device. RESULTS: Significant differences were yielded between the skin tensile properties in patients and normal subjects. The highest IGF-1 values in the patients' medical records were positively correlated with both skin distensibility and biologic elasticity. The most recent IGF-1 serum levels were negatively correlated with the visco-elastic ratio. No correlations were yielded between any of the biomechanical parameters and GH levels, disease duration and treatment dosages, respectively. CONCLUSION: The skin in acromegaly appears to be functionally more redundant and elastic than normal skin. The biomechanical changes appear quite different from those observed in other diseases with collagen deposition such as diabetes mellitus and scleroderma. [less ▲]

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See detailImproving the performance of low-gain designs for bounded control of linear systems
Grognard, F.; Sepulchre, Rodolphe ULg; Bastin, G.

in Automatica (2002), 38(11), 1777-1782

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See detailOn the specificity of cyclodextrin complexes detected by electrospray mass spectrometry
Gabelica, Valérie ULg; Galic, Nives; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2002), 13(8), 946-953

alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant ... [more ▼]

alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant that increases with the diacid chain length. However, the electrospray mass spectrometry (ES-MS) spectra showed that the relative intensity of the complex did not vary significantly with chain length. This contradiction is caused by a contribution of nonspecific adducts to the signal of the complex in ES-MS. In order to estimate the contribution of nonspecific adducts to the total intensity of the complexes with alpha-cyclodextrin, the comparison was made between alpha-cyclodextrin and maltohexaose, the latter being incapable of making inclusion complexes in solution. The signal observed for complexes between diacids and maltohexaose can only result from nonspecific electrostatic aggregation, and is found to be more favorable with the shorter diacids. This is also supported by MS/MS experiments. A procedure is described which allows estimation of the contribution of the nonspecific complex in the spectra of the complexes with alpha-cyclodextrin by using the relative intensity of the complex with maltohexaose. The contribution of the specific complex to the total signal intensity is found to increase with the diacid chain length, which is in agreement with solution behavior. [less ▲]

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See detailInteractions between the cytochrome pathway and the alternative oxidase in isolated Acanthamoeba castellanii mitochondria.
Jarmuszkiewicz, W.; Sluse, Francis ULg; Hryniewiecka, L. et al

in Journal of Bioenergetics & Biomembranes (2002), 34(1), 31-40

The steady-state activity of the two quinol-oxidizing pathways of Acanthamoeba castellanii mitochondria, the phosphorylating cytochrome pathway (i.e. the benzohydroxamate(BHAM)-resistant respiration in ... [more ▼]

The steady-state activity of the two quinol-oxidizing pathways of Acanthamoeba castellanii mitochondria, the phosphorylating cytochrome pathway (i.e. the benzohydroxamate(BHAM)-resistant respiration in state 3) and the alternative oxidase (i.e. the KCN-resistant respiration), is shown to be fixed by ubiquinone (Q) pool redox state independently of the reducing substrate (succinate or exogenous reduced nicotinamide adenine dinucleotide (NADH)), indicating that the active Q pool is homogenous. For both pathways, activity increases with the Q reduction level (up to 80%). However, the cytochrome pathway respiration partially inhibited (about 50%) by myxothiazol decreases when the Q reduction level increases above 80%. The decrease can be explained by the Q cycle mechanism of complex III. It is also shown that BHAM has an influence on the relationship between the rate of ADP phosphorylation and the Q reduction level when alternative oxidase is active, and that KCN has an influence on the relationship between the alternative oxidase activity and the Q reduction level. These unexpected effects of BHAM and KCN observed at a given Q reduction level are likely due to functional connections between the two pathways activities or to protein-protein interaction. [less ▲]

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See detailRapid And Homogenous Detection Of Apple Stem Pitting Virus By Rt-Pcr And A Fluorogenic 3 ' Minor Groove Binder-Dna Probe
Salmon, Marc ULg; Vendrame, Marina; Kummert, Jean et al

in European Journal of Plant Pathology (2002), 108(8), 755-762

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See detailCharacterization of porous texture of hyperporous materials by mercury porosimetry using densification equation
Pirard, René ULg; Alié, Christelle ULg; Pirard, Jean-Paul ULg

in Powder Technology (2002), 128(2-3), 242-247

The purpose of this paper is to propose a method of analyzing the mercury porosimetry data in the case of materials called hyperporous. This class of material does not undergo intrusion by mercury ... [more ▼]

The purpose of this paper is to propose a method of analyzing the mercury porosimetry data in the case of materials called hyperporous. This class of material does not undergo intrusion by mercury; instead, it shrinks under the mercury isostatic pressure and its density increases. The phenomenon is partially or completely irreversible. The proposed method enables computing the pore volume distribution as a function of the pore size in the same way as Washburn's method does in the case of mercury intrusion. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailL'etude clinique du mois. L'etude LIPS: prevention par la fluvastatine des accidents cardiaques apres angioplastie coronaire percutanee.
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(7), 479-82

The prospective placebo-controlled LIPS study ("Lescol Intervention Prevention Study") demonstrated a significant cardiovascular protection by fluvastatin in patients with coronary artery disease (stable ... [more ▼]

The prospective placebo-controlled LIPS study ("Lescol Intervention Prevention Study") demonstrated a significant cardiovascular protection by fluvastatin in patients with coronary artery disease (stable or unstable angina, silent ischemia), without major hypercholesterolaemia (135-270 mg/dl) following successful completion of their first percutaneous coronary intervention. When compared to the placebo group (n = 833), the fluvastatin group (n = 844) showed a relative risk reduction by 22% (relative risk: 0.78; 95% confidence interval: 0.64-0.95; p = 0.01) of major adverse cardiac events after a median time of follow-up of 3.9 years. This effect is observed independently of baseline total cholesterol, of the presence of diabetes mellitus or the existence of multivessel disease. These results suggest that fluvastatin may favorably influence the restenosis process after percutaneous coronary intervention, even in the absence of severe hypercholesterolaemia. [less ▲]

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