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See detailLa morphologie synchronique du nom latin. Une bibliographie de base (1962-1991)
Pietquin, Paul ULg; Isebaert, Lambert

in Orbis : Bulletin international de documentation linguistique (1993), 36

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See detailCloning and characterization of G protein-coupled receptors
Parmentier, M.; Libert, F.; Perret, J. et al

in Advances in Second Messenger and Phosphoprotein Research (1993), 28

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See detailGLUCOCORTICOIDS AS DOPING AGENTS IN HOMING PIGEONS
Duchatel, Jean-Pierre ULg; Beduin, Jean-Marie ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1993), 137(8), 557-564

Different commercially available glucocorticoids that could be used to dope racing pigeons have been evaluated using zootechnical and biological parameters. The influence of these corticosteroids on blood ... [more ▼]

Different commercially available glucocorticoids that could be used to dope racing pigeons have been evaluated using zootechnical and biological parameters. The influence of these corticosteroids on blood values have been investigated. Toxicity of triamcinolone diacetate varied proportionally to injected doses and the main effects observed were lymphoid tissue alterations, muscular atrophy with breast muscles fibers vacuolation, fatty degeneration of liver and kidneys, hypoplasia or atrophy of gonads, and, in the blood, a significant increase of calcium and triglycerides levels. Prednisolone acetate in ocular drops was less toxic than dexemathasone and fluocinolone acetonide. The type of corticoids also had an influence on hemoglobin, glucose, and creatinine levels. The inhibition of the molt was also observed and varied with the sort of product used. [less ▲]

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See detailReaction Dynamics of the Dichlorocarbene Anion Using tandem Mass Spectrometry.
Leyh, Bernard ULg; Mélon, Pierre

in Organic Mass Spectrometry (1993), 28

The dissociation dynamics of CCl2- anions were studied under various internal energy conditions. This study involved the measurement of daughter-ion spectra and branching ratios and of the amount of ... [more ▼]

The dissociation dynamics of CCl2- anions were studied under various internal energy conditions. This study involved the measurement of daughter-ion spectra and branching ratios and of the amount of kinetic energy released (KER) on the fragments. The competition between C and Cl loss for CCl2- ions created by many of the following sequence of processes: CCl4->CCl2+->(G=Xe, Kr C6H6)->CCl2--> fragments (1); CCl4->(CCl2--+[Cl,Cl]+;CCl2-; CCl2- (Ne)-> Fragments (2); CCl4->(CCl2)2+ (C6H6)->CCl2--> fragments (3) was particularly investigated. For process (1), the amount of fragmentating CCl2- ions is 8-10 times larger with Kr than with Xe or C6H6. The KER for Cl loss is smaller than 0.20 eV with the three target gases used. For the loss of C, the KER is much larger (0.7 eV). This KER is, however, equal to 0.21 eV for the collisionally activated C loss in process (2). For this latter process, the C loss vs Cl loss branching ratio decreases with increasing internal energy. The KERs measured for process (3) are vary similar to those obtained for process (1). It is suggested that repulsive or slightly bound excited states which correlate directly to the Cl2-(X2Sigma+)+C asymptote and which are vibronically coupled to the ground state play an important role in these dissociation processes. [less ▲]

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See detailDinant/Anseremme: Trou Magrite
Noiret, Pierre ULg

in Chronique de l'Archéologie wallonne (1993), 1

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See detailThe peripheral analgesic effects of opiods
Joris, Jean ULg; Hargreaves, Kenneth M

in APS Journal (1993), 2(1), 51-59

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See detailEffects of Neurochemical Lesions of the Preoptic Area on Male Sexual Behavior in the Japanese Quail
Bailhache, T.; Surlemont, C.; Balthazart, Jacques ULg

in Brain Research Bulletin (1993), 32(3), 273-83

Two experiments were carried out during which the noradrenergic neurotoxin, 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine (5-ADMP) was applied to the brain of quail in order to evaluate the role of ... [more ▼]

Two experiments were carried out during which the noradrenergic neurotoxin, 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine (5-ADMP) was applied to the brain of quail in order to evaluate the role of the noradrenergic system in the control of male copulatory behavior. In the first experiment, the ICV injection of 5-ADMP slightly enhanced the sexual behavior observed in testosterone (T)-treated castrated male quail. This brings additional support to the notion that norepinephrine tonically inhibits male copulatory behavior in quail. In the second experiment, 5-ADMP implanted directly into the preoptic area disrupted the restoration by T of copulatory behavior in castrated quail and, at the same time, produced a brain lesion that partly destroyed the sexually dimorphic medial preoptic nucleus, a previously established site of T action on behavior. These lesions produced by a high (presumably too high) concentration of neurotoxin provided an independent confirmation of effects previously observed after electrolytic lesions. Correlation analyses also confirmed that the medial part of the POM just rostral to the anterior commissure is more closely associated with copulatory behavior and may, therefore, represent a key center for steroid action on this behavior. [less ▲]

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See detailComparison between culture of bovine embryos in vitro versus development in rabbit oviducts and in vivo
Ectors, Fabien ULg; Thonon, Fabienne; Delval, Alain et al

in Livestock Production Science (1993), 36

The aim of this work was to evaluate the efficiency of different embryo culture methods for in vitro embryo production: development in co-culture with bovine oviductal epithelial cells (BOEC), in BOEC ... [more ▼]

The aim of this work was to evaluate the efficiency of different embryo culture methods for in vitro embryo production: development in co-culture with bovine oviductal epithelial cells (BOEC), in BOEC conditioned medium (CM) or in rabbit oviducts, versus in vivo produced embryos. There was no significant difference in terms of percentages of cleaved and 8-cell stages obtained between CM and BOEC. In CM, 24.8% of the cleaved embryos became blastocysts. In BOEC, 14.5% of the cleaved embryos became blastocysts. Among the 190 zygotes transferred in the rabbit oviducts, 127 have been recovered 5 days later, and 17.4% became blastocysts. There was no significant difference in term of blastocyst formation between the development in rabbit and in BOEC. However, there was a significant difference between the CM group and the two other groups. The numbers of cells in blastocysts from different sources were investigated: in vivo blastocysts contained 107 cells assumed to be 100%, in vitro blastocysts developed in rabbit oviduct 100.1 cells (93.3%), BOEC blastocysts 90.8 cells (84.6%) and CM blastocysts 72.3 cells (67.3%). This study confirmed earlier works on the oviduct effect on blastocyst quality in terms of development rate and cell number. [less ▲]

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See detailLésion du nerf spinal accessoire
WANG, François-Charles ULg; Laurent, Luc; CRIELAARD, Jean-Michel ULg

in Acta physiotherapeutica (1993)

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See detailLe traitement des adénomes à prolactine : utilisation d'un nouvel agoniste dopaminergique à longue durée d'action, la cabergoline, chez 56 patients
Beckers, Albert ULg; Abs, R.; Demez, Pierre ULg et al

in Médecine et Hygiène (1993), 51(1990), 1978-1980

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de ... [more ▼]

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de macroadénome dans 21 cas ont été traités durant des périodes variant entre 1 et 17 mois à des doses de cabergoline variant entre 0,25 mg et 2 mg par semaine, prises à raison de 1 à 4 fois par semaine. Cette nouvelle substance nous est apparue extrêmement efficace et très bien tolérée [less ▲]

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See detailLaparoscopic surgery, urology and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailUltrastructure of CD57+ cells isolated from human tonsils or blood.
Bouzahzah, F.; Heinen, Ernst ULg; Antoine, Nadine ULg et al

in European Journal of Morphology (1993), 31(1-2), 82-6

The presence of CD4+, CD57+ T cells in the germinal centers has been reported by several authors. The CD57 antigen is also expressed by natural killer (NK) cells. We purified CD57+ cells from human ... [more ▼]

The presence of CD4+, CD57+ T cells in the germinal centers has been reported by several authors. The CD57 antigen is also expressed by natural killer (NK) cells. We purified CD57+ cells from human tonsils and blood by microdissection, rosetting with sheep red blood cells and magnetic cell sorting (MACS) and examined the ultrastructural morphology of these cells. Clear differences were found in cell aspect: blood NK contained large granules which were not found in the tonsillar CD57+ cells. These latter appeared medium-sized and not fully activated. After immunolabeling, the tonsillar CD57+ cells were mainly found in the light zone of the germinal centers. [less ▲]

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See detailAnalytical calculation of the electrostatic interaction energy within the CNDO framework
Dehareng, Dominique ULg; Dive, Georges ULg; Ghuysen, Jean-Marie ULg

in International Journal of Quantum Chemistry (1993), 46(6), 711-734

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab ... [more ▼]

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab initio results for small systems such as water-formamide, methanol-water-imidazole, or guanine-cytosine and with AM1 results for two large systems: a molecular tweezer + the 9-methyladenine complex and a model active site of the alpha-chymotrypsin and its ligand complex. This approach is efficient in providing reliable conformers for large molecular systems in a very fast way. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Stavební Obzor (1993), 10

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See detailIdentification of 108k, 93k, and 42k Glycoproteins of Bovine Herpesvirus-1 by Monoclonal Antibodies
Baranowski, E.; Dubuisson, J.; Pastoret, Paul-Pierre ULg et al

in Archives of Virology (1993), 133(1-2), 97-111

Three glycoproteins of bovine herpesvirus-1 (BHV-1) other than glycoproteins gI, gIII, and gIV were identified by monoclonal antibody (MAb) analyses. Monoclonal antibodies were obtained by immunization of ... [more ▼]

Three glycoproteins of bovine herpesvirus-1 (BHV-1) other than glycoproteins gI, gIII, and gIV were identified by monoclonal antibody (MAb) analyses. Monoclonal antibodies were obtained by immunization of mice with either BHV-1 envelope or virus infected cells, from which the glycoproteins gI, gIII, and gIV were removed by immunoaffinity. In the latter immunization procedure mice were tolerized either against normal cellular antigens with or without glycoproteins gI, gIII, gIV, and nucleocapsid. From 154 anti-BHV-1 hybridomas isolated, 39 MAbs precipitated a 108K glycoprotein. Two other glycoproteins of respectively 42K and 93K were precipitated each by one MAb. These three glycoproteins were detected in infected cell lysate. Nine anti-108K glycoprotein MAbs neutralized BHV-1 infectivity and three non-neutralizing MAbs were able to reduce plaque development when virus was grown in the presence of these MAbs. It is therefore suggested that this glycoprotein is involved in viral entry into the cell and in cell-to-cell spread of the virus. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1993), n°1

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See detailEmperipolesis of lymphoid cells by human follicular dendritic cells in vitro.
Tsunoda, R.; Nakayama, M.; Heinen, Ernst ULg et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailRestriction Maps of the DNA of Cervid Herpesvirus 1 and Cervid Herpesvirus 2, Two Viruses Related to Bovine Herpesvirus 1
Vanderplasschen, Alain ULg; Bublot, M.; Pastoret, Paul-Pierre ULg et al

in Archives of Virology (1993), 128(3-4), 379-88

Restriction maps of cervid herpesviruses 1 and 2 which are antigenetically related to bovine herpesvirus 1, were deduced from Southern blot hybridization with HindIII restriction fragments of BHV-1 DNA as ... [more ▼]

Restriction maps of cervid herpesviruses 1 and 2 which are antigenetically related to bovine herpesvirus 1, were deduced from Southern blot hybridization with HindIII restriction fragments of BHV-1 DNA as probes. [less ▲]

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See detailProperties and primary structure of a cold-adapted lipase from an Antarctic bacterium
Arpigny, J. L.; Feller, Georges ULg; Gerday, Charles ULg

in Archives Internationales de Physiologie et de Biochimie (1993), 101

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See detailSolid-state nuclear magnetic resonance studies of the transformation of the zeolite Y catalyst in the course of hydrochlorination of 1-methylcyclohexene by thionyl chloride
Kolodziejski, Waclaw; Delaude, Lionel ULg; Laszlo, Pierre ULg et al

in Applied Catalysis A : General (1993), 98(1), 71-79

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated ... [more ▼]

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated framework aluminium in the parent sample coexisting with a small amount of immobile extra-framework aluminium at ca. -1 ppm is completely removed after just one reaction run and transformed into two distinct 6-coordinated species resonating at 0.2 and -3.1 ppm. The former line is assigned to Al(H2O)63+ cations, the latter is likely to come from a species with mixed solvation shells, probably Al(Cl-)(H2O)52+ and Al(OH-)(H2O)52+. Crystallinity of the catalyst is seriously affected by the reaction. The spectra confirm that before reaction the zeolite contains Si(3Si,1OH) and Si(2Si,2OH) groups. During the reaction most hydroxyl groups created by dealumination are removed, although some Si(3Si,1OH) remain. MAS NMR spectra are fully consistent with the proposed reaction mechanism. [less ▲]

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See detailMeasurement of the 2s2p2(4P)3s 3P2 lifetime in N II by beam-foil-laser spectroscopy
Bastin, Thierry ULg; Baudinet-Robinet, Y.; Garnir, Henri-Pierre ULg et al

in Journal Physical II (1993), 3

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the ... [more ▼]

An accurate value for the radiative lifetime of the 2s2p2(4P)3s3P2 level in N II has been obtained using the beam-foil-laser spectroscopy method. The result (T = 0.456 ± 0.020 ns ) is shorter than the beam-foil lifetime values reported previously for the 3s' 3P term. No theoretical value for the lifetime of this term is available at the present time. [less ▲]

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See detailHeightened selectivity in aromatic nitrations and chlorinations by the use of solid supports and catalysts
Delaude, Lionel ULg; Laszlo, Pierre ULg; Smith, Keith

in Accounts of Chemical Research (1993), 26(12), 607-613

The heightened selectivity in aromatic nitrations and chlorinations using solid supports and catalysts is reviewed with 67 references.

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See detailThe oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.
Bours, Vincent ULg; Franzoso, G.; Azarenko, V. et al

in Cell (1993), 72(5), 729-39

Bcl-3 is an I kappa B-related protein with ankyrin repeat motifs. Its gene is located at a site of recurrent translocations in a subset of B cell chronic lymphocytic leukemias. Bcl-3 associates tightly ... [more ▼]

Bcl-3 is an I kappa B-related protein with ankyrin repeat motifs. Its gene is located at a site of recurrent translocations in a subset of B cell chronic lymphocytic leukemias. Bcl-3 associates tightly with p50B (NFKB2, p52) homodimers in cells, and together these proteins form a ternary complex with DNA at kappa B sites. Such an association functionally leads to a novel and potent form of transactivation through the kappa B motif: the tethering of Bcl-3 to DNA via the p50B homodimers allows Bcl-3 to transactivate directly, while p50B homodimers alone cannot. Transactivation mediated by Bcl-3 requires two cooperating domains located amino- and carboxy-terminal to the ankyrin domain. Bcl-3 is localized to the nucleus, and a Bcl-3-p50B complex is detected in certain lymphoid cells. Our data reveal a novel role for Bcl-3, distinct from that of the inhibitor I kappa B. The results have implications for tumorigenesis. [less ▲]

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See detailNitric oxide: a new messenger in the brain.
Bruhwyler, J.; Chleide, E.; Liégeois, Jean-François ULg et al

in Neuroscience & Biobehavioral Reviews (1993), 17(4), 373-84

The important role played by nitric oxide (NO) in the central nervous system has largely been emphasized in the recent literature. It can originate at least from four different sources: the endothelium of ... [more ▼]

The important role played by nitric oxide (NO) in the central nervous system has largely been emphasized in the recent literature. It can originate at least from four different sources: the endothelium of cerebral vessels, the immunostimulated microglia and astrocytes, the nonadrenergic noncholinergic nerve, and the glutamate neuron. NO has been implicated in a large number of pathologies (such as neurotoxicity in Alzheimer's disease and Huntington's disease, cerebral ischemia, stroke, and anxiety) and also in normal physiological functions (such as memory and learning, regulation of the cerebrovascular system, modulation of the wakefulness, mediation of nociception, olfaction, food intake and drinking, regulation of noradrenaline, and dopamine release). The aim of this paper is to review and to integrate the most recent advances in our understanding of the roles of NO in the brain. [less ▲]

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See detailThe Appearance of C2H3+ Ions from C2H3F by non-resonant Photoionization. A Translational Energy Surprisal Analysis.
Momigny, J.; Locht, Robert ULg

in Chemical Physics Letters (1993), 211(2,3), 161-165

It is shown that for a photon energy of 16.85 eV the translational energy surprisal of the C2H3++F dissociation products from C2H3F+ has a bimodal behaviour. The possibility of considering the bimodal ... [more ▼]

It is shown that for a photon energy of 16.85 eV the translational energy surprisal of the C2H3++F dissociation products from C2H3F+ has a bimodal behaviour. The possibility of considering the bimodal surprisal as due to the superposition of two translational energy distributions is consistent with the theoretical assumption of the concurrence of two channels in this dissociation process. The characteristics of these distributions, i.e. the energy width and the relative abundance, are in agreement with the results of an ab initio quantum-mechanical calculation of the dynamics of this dissociation. They are consistent with the simultaneous occurrence of a statistical dissociation of C2H3F+(X2A') into C2H3+(X1A') and an isolated state dissociation of C2H3F+(C2A") into C2H3+(a3A"). Negative lambda values obtained for the surprisal of both these distributions indicate an inversion of the translational level population of the dissociation products. [less ▲]

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See detailKaberdoes
Vromans, Joseph ULg

in Nederlands Van Nu (1993), 41(5),

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See detailExteroceptive suppression of temporalis muscle activity: methodological and physiological aspects.
Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1993), 13(1), 3-10

In recent years studies of the suppression of EMG activity in temporalis muscle induced by stimulation in the trigeminal territory have opened new perspectives in headache research. The various methods ... [more ▼]

In recent years studies of the suppression of EMG activity in temporalis muscle induced by stimulation in the trigeminal territory have opened new perspectives in headache research. The various methods that have been used in different laboratories are reviewed and some of the physiological modulations of temporalis exteroceptive suppression are described. Among different methods of recording, averaging 10 full-wave rectified EMG responses produces results with acceptable variability and discomfort. In order to obtain maximal responses the intensity of the stimulation should reach at least 20 mA. To avoid habituation of the second temporalis exteroceptive suppression period (ES2), the stimulation frequency has to be at 0.1 Hz or below. The level of voluntary contraction is not a critical variable as long as it reaches 50% of maximum. Some physiological variations of temporalis suppression are well documented. In females, ES2 is shorter during menstruation than at mid-cycle and correlated with the estradiol/progesterone ratio in plasma. Conditioning temporalis ES2 by a preceding peripheral stimulus markedly reduces its duration, which is partly reversible by naloxone. Various pharmacological agents are able to modify temporalis ES2: its duration is increased by 5-HT1 antagonists, but decreased by 5-HT uptake blockers; contradictory results have been obtained with acetylsalicylic acid. These results suggest that inhibitory brain-stem interneurons mediating temporalis ES2 are inhibited by serotonergic afferents, probably from the raphe magnus nucleus, and that the latter receives an excitatory input from the periaqueductal gray matter and other limbic structures, in part via opioid receptors. [less ▲]

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See detailOkadaic acid, a protein phosphatase inhibitor, enhances transcription of a receptor gene containing sequence A of the human prolactin promoter
Wera, S.; Belayew, A.; Martial, Joseph ULg

in Molecular Endocrinology (1993), 7(8), 965-71

Human PRL (hPRL) gene expression is controlled by cAMP and Ca2+. This control is mediated by two cis-elements: a Pit-1 binding site (-62 to -35) and sequence A (-110 to -85), present in the hPRL promoter ... [more ▼]

Human PRL (hPRL) gene expression is controlled by cAMP and Ca2+. This control is mediated by two cis-elements: a Pit-1 binding site (-62 to -35) and sequence A (-110 to -85), present in the hPRL promoter. We have investigated whether protein phosphatases could be involved in this regulation. GC-type rat pituitary tumor cells were transfected with sequence -138 to -35 of the hPRL gene promoter, upstream from a thymidine kinase promoter and a chloramphenicol acetyltransferase (CAT) reporter gene. Addition of okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, stimulates transient expression of the CAT gene. The dose-response curve shows a maximal effect at 25 nM OA (2.2-fold stimulation above controls). The OA effect is also observed with a natural 4500-base pair hPRL promoter. A single copy of the hPRL promoter sequence -115 to -85 (sequence A) confers to a thymidine kinase-CAT construct an identical response to OA, whereas a single copy of the proximal Pit-1 binding site does not. Synergism is observed between cAMP and OA in activating PRL gene transcription. This synergism is also observed with a single copy of sequence A. The effect of cAMP is not mediated by an L-type Ca2+ channel, since addition of the Ca2+ channel antagonist verapamil does not decrease it, nor does complexing extracellular Ca2+ significantly reduce it. Furthermore, OA and the Ca2+ channel opener BAY K8644 exert additive effects. [less ▲]

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See detailTEM investigation of transition phases precipitation in ZA alloys after isothermal aging at 250°C and subsequent creep at high temperature
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Wegria, J.

in Materials Science Forum (Intergranular and Interphase Boundaries in Materials) (1993), 126-128

Transition phases occurring during isothermal aging at 250°C af ternary Zri-A1-Cu alloys are modlifîed after creep at high temperature. fle pressure applkd during creep leads to a high dertsity of clef ... [more ▼]

Transition phases occurring during isothermal aging at 250°C af ternary Zri-A1-Cu alloys are modlifîed after creep at high temperature. fle pressure applkd during creep leads to a high dertsity of clef ects which modifies the ndcrostructure. 11e trnsitiôn phases are studied by me ans of transmission electron microscopy and diffraction technique. Œ’r and phases pile up on dislocations. 11e reaction «s + £ 4 T +r 1$ accelerated and the transition T’ -. e’ is proxnoted by the defects. [less ▲]

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See detailHet Craeckhuys van de Bijloke in Gent, dendrochronologische analyse van houtmonsters
Hoffsummer, Patrick ULg; Houbrechts, David

in Stadsarcheologie (1993), 17(4), 24-29

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See detailPurification Of Antifungal Lipopeptides By Reversed-Phase High-Performance Liquid-Chromatography
Razafindralambo, Hary ULg; Paquot, Michel ULg; Hbid, Choukri et al

in Journal of Chromatography. A (1993), 639(1), 81-85

A rapid procedure for the purification of antifungal lipopeptides from Bacillus subtilis, a potential agent for biocontrol of plant diseases, was tested. It consists of a solid-phase extraction on C18 gel ... [more ▼]

A rapid procedure for the purification of antifungal lipopeptides from Bacillus subtilis, a potential agent for biocontrol of plant diseases, was tested. It consists of a solid-phase extraction on C18 gel followed by reversed-phase chromatography using a biocompatible PepRPC HR 515 column with a pharmacia fast protein liquid chromatographic system. This is a very effective method for isolating and fractionating iturin A and surfactin, two lipopeptides of different nature, co-produced by Bacillus subtilis strain S499. The presence of homologous lipopeptides was easily detected. [less ▲]

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See detailTransmission du virus BVD/MD et aspects épidémiologiques de l'infection
Boulanger, D.; Quatpers, D.; Mignon, Bernard ULg et al

in Bulletin des Groupements Techniques Vétérinaires (1993), 4

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See detailEscherichia coli productrices de la toxine cytotoxique nécrosante de type 1 (CNF1) isolées à partir de processus pathologiques chez des chats et des chiens
Pohl, P.; Mainil, Jacques ULg; Devriese, L. et al

in Annales de Médecine Vétérinaire (1993), 137

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See detailCytokine and anti-cytokine strategies in inflammatory reaction modulation
Delannoy, I.; Lekeux, Pierre ULg; Miossec, P.

in Veterinary Research (1993), 24

Evidence of the importance of a cytokine cascade in the induction and control of the inflammatory reaction is increasing. Although cytokines are required in the inflammatory process in response to ... [more ▼]

Evidence of the importance of a cytokine cascade in the induction and control of the inflammatory reaction is increasing. Although cytokines are required in the inflammatory process in response to infection or injury, their overproduction, particularly that of interleukin-1 (IL-1) and tumor necrosis factor (TNF), can lead to local/systemic pathology. Selective inhibition of the synthesis or of the action of specific cytokines may be of therapeutic benefit. Various strategies for blocking IL-1 and TNF activities have been presented. While selective inhibition of cytokine synthesis is still in the early experimental phase, specific blockade of soluble cytokine action following synthesis and release from cells is undergoing preliminary clinical trials in humans. Animal data suggest that antimonoclonal therapy such as monoclonal antibodies to TNF, IL-1 receptor antagonists or soluble receptors to TNF and IL-1 can be effective in the modulation of the inflammatory reaction. Modulation of the cytokine network in some diseases might also include the use of anti-inflammatory cytokines. Nonetheless, the possibilities of side effects due to impaired host-defense mechanisms with the IL-1 or TNF blockade must also be taken into consideration. [less ▲]

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See detailApplication de l'analyse fréquentielle à haute résolution
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Bulletin d'Audiophonologie (1993), IX(5), 490-497

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur ... [more ▼]

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur dans le placement de la voix dans les résonateurs. Il s'observe plus particulièrement sur un fondamental grave et s'acquiert par technique et expérience. 2. L'observation du vibrato, qu'il convient d'avoir vu avant, son observation graphique pourrait être considérée comme pathologique. [less ▲]

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See detailRetinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers.
Segars, J. H.; Nagata, T.; Bours, Vincent ULg et al

in Molecular & Cellular Biology (1993), 13(10), 6157-69

Retinoic acid (RA) treatment of human embryonal carcinoma (EC) NTera-2 (NT2) cells induces expression of major histocompatibility complex (MHC) class I and beta-2 microglobulin surface molecules. We found ... [more ▼]

Retinoic acid (RA) treatment of human embryonal carcinoma (EC) NTera-2 (NT2) cells induces expression of major histocompatibility complex (MHC) class I and beta-2 microglobulin surface molecules. We found that this induction was accompanied by increased levels of MHC class I mRNA, which was attributable to the activation of the two conserved upstream enhancers, region I (NF-kappa B like) and region II. This activation coincided with the induction of nuclear factor binding activities specific for the two enhancers. Region I binding activity was not present in undifferentiated NT2 cells, but binding of an NF-kappa B heterodimer, p50-p65, was induced following RA treatment. The p50-p65 heterodimer was produced as a result of de novo induction of p50 and p65 mRNAs. Region II binding activity was present in undifferentiated cells at low levels but was greatly augmented by RA treatment because of activation of a nuclear hormone receptor heterodimer composed of the retinoid X receptor (RXR beta) and the RA receptor (RAR beta). The RXR beta-RAR beta heterodimer also bound RA responsive elements present in other genes which are likely to be involved in RA triggering of EC cell differentiation. Furthermore, transfection of p50 and p65 into undifferentiated NT2 cells synergistically activated region I-dependent MHC class I reporter activity. A similar increase in MHC class I reporter activity was demonstrated by cotransfection of RXR beta and RAR beta. These data show that following RA treatment, heterodimers of two transcription factor families are induced to bind to the MHC enhancers, which at least partly accounts for RA induction of MHC class I expression in NT2 EC cells. [less ▲]

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See detailSub-mesoscale Air-sea Interactions
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Journal of Marine Systems (1993), 4(2-3),

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See detailSaving behavior in 17 OECD countries
Kessler, Denis; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Review of Income and Wealth (1993), (39), 37-50

This article compares savings behavior in a sample of 17 OECD countries over 24 years. On the basis of an analysis of variance and of a life-cycle-hypothesis-based equation, we test the homogeneity of ... [more ▼]

This article compares savings behavior in a sample of 17 OECD countries over 24 years. On the basis of an analysis of variance and of a life-cycle-hypothesis-based equation, we test the homogeneity of households' savings behavior. It appears that one cannot really speak of a homogeneous saving behavior across countries. This is a relevant finding in times of increasing economic and financial integration. [less ▲]

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See detailCompte-rendu de l'ouvrage : Avignon au Moyen Age. Textes et documents
Xhayet, Geneviève ULg

in Moyen Age (Le) (1993), 99

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See detailModifications of the extracellular matrix of aneurysmal abdominal aortas as a function of their size.
SAKALIHASAN, Natzi ULg; HEYERES, Antoine ULg; Richelle, Betty ULg et al

in European Journal of Vascular Surgery (1993), 7(6), 633-7

Collagen and elastin are the main extracellular matrix proteins providing the aortic wall with adequate mechanical properties and resistance for proper function. Our study aimed at investigating the ... [more ▼]

Collagen and elastin are the main extracellular matrix proteins providing the aortic wall with adequate mechanical properties and resistance for proper function. Our study aimed at investigating the relationship between the elastin concentration of the wall of normal and aneurysmal abdominal aortas (AAA), the collagen concentration, and its extractability, as a function of their size. Infrarenal aortas were collected from 30 patients undergoing operative repair of abdominal aortic aneurysm. Age-matched control samples were obtained from eight autopsies of individuals without vascular disease. Samples were divided into five groups according to the aortic diameter: control group (group N, n = 8); < 50 mm (group I, n = 6; between 50-75 mm (group II, n = 10); > 75 mm (group III, n = 7); and ruptured (group IV, n = 7). The collagen concentration in samples from group I was similar to the controls. An increased collagen concentration was observed in group II and remained at the same level in the largest and ruptured aneurysms. Extractability of collagen was found to be increased in group III and was even higher in group IV. A highly significant reduction in elastin concentration was observed in group I and there was progressive reduction with increasing diameter and rupture. A significant correlation could be established between aortic diameter, increased collagen extractability and decreased elastin content. [less ▲]

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See detailA new topical treatment for resistant herpes simplex infections.
Snoeck, R.; Andrei, G.; De Clercq, E. et al

in New England Journal of Medicine [=NEJM] (1993), 329(13), 968-9

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See detailNew gamma-lactam homologs of penems
Marchand-Brynaert, Jacqueline; Couplet, Blandine; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry Letters (1993), 3(11), 2303-2308

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See detailThe oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
Franzoso, G.; Bours, Vincent ULg; Azarenko, V. et al

in EMBO Journal (1993), 12(10), 3893-901

Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit of NF ... [more ▼]

Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit of NF-kappa B. Such homodimers are abundant for example in nuclei of unstimulated primary T cells. Here we extend the model and provide new evidence which fulfills a number of predictions. (i) Bcl-3 preferentially targets p50 homodimers over NF-kappa B heterodimers since the homodimers are completely dissociated from kappa B sites at concentrations of Bcl-3 which do not affect NF-kappa B. (ii) Select kappa B sites associate very strongly and stably with p50 homodimers, completely preventing binding by NF-kappa B. Such kappa B sites are likely candidates for regulation by p50 homodimers and Bcl-3. (iii) Bcl-3 and p50 can be co-localized in the nucleus, a requirement for active removal of homodimers from their binding sites in vivo. (iv) The ankyrin repeat domain of Bcl-3 is sufficient for the reversal of p50 homodimer-mediated inhibition, correlating with the ability of this domain alone to inhibit p50 binding to kappa B sites in vitro. Our data support the model that induction of nuclear Bcl-3 may be required during cellular stimulation to actively remove stably bound p50 homodimers from certain kappa B sites in order to allow transactivating NF-kappa B complexes to engage. This exact mechanism is demonstrated with in vitro experiments. [less ▲]

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See detailLe pilotage de l'enseignement des sciences : un essai de synthèse...
Rousselet, S.; Monseur, Christian ULg

in Informations pédagogiques (1993), 9

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See detailSynthetic model peptides for apolipoproteins. II. Characterization of the discoidal complexes generated between phospholipids and synthetic model peptides for apolipoproteins.
Corijn, J.; Deleys, R.; Labeur, C. et al

in Biochimica et Biophysica Acta (1993), 1170(1), 8-16

The structure, composition and physico-chemical properties of complexes generated between phospholipids and synthetic model peptides for the amphipathic helices of the plasma apolipoproteins were studied ... [more ▼]

The structure, composition and physico-chemical properties of complexes generated between phospholipids and synthetic model peptides for the amphipathic helices of the plasma apolipoproteins were studied. The sequences of the peptides were derived from that of the 18A peptide and designed to either enhance or decrease ionic interactions between pairs of peptides, as described in the accompanying paper. Complexes were prepared with dimyristoylphosphatidylcholine (DMPC), dipalmitoylphosphatidylcholine (DPPC), or with DPPC and cholesterol, and isolated on a Superose 6HR column. Association kinetics for the DMPC-peptides complexes were followed by measuring the turbidity as a function of the temperature. The diameters of the DPPC-peptide complexes, measured by gradient gel electrophoresis (GGE), were about 120 A. Fluorescence polarization measurements after labeling with diphenyl hexatriene (DPH) yielded transition temperatures of, respectively, 40.6, 41.5 and 41.8 degrees C for the DPPC/18AM1-, DPPC/18AM4- and DPPC/18A-peptide complexes. These values were confirmed by differential scanning calorimetry. Circular dichroism and infrared spectroscopy revealed that the peptides adopt an alpha-helical structure in solution and this percentage increased from 30-40% in the free peptides up to 50-60% in the complexes. Attenuated total reflection (ATR) infrared measurements of the complexes indicated that the peptides are oriented parallel to the acyl chains of the phospholipid bilayer. Denaturation of the peptides and of the peptide-lipid complexes was monitored by Trp fluorescence under addition of increasing amounts of GdmCl. The mid-points of the denaturation curves lie at, respectively, 0.05, 0.25 and 0.35 M GdmCl for the 18AM4, 18A and 18AM1 peptide and are shifted towards higher GdmCl concentrations after peptide-lipid binding. GdmCl denaturation decreased the alpha-helical content of the peptides and of the complexes, as monitored by circular dichroism measurement. The helix to random coil structure transition occurred at, respectively, 2.1, 2.2, and 2.0 M GdmCl for 18A, 18AM1 and 18AM4, compared to 5.1, 5.0, and 5.3 M in the corresponding complexes. These data suggest altogether that the structural properties, the mode of lipid-protein association and the stability of the phospholipid-peptide complexes are similar to those of native plasma apolipoproteins. The 18A and 18AM4 peptides which contain charged residues along the edge of the helix, leading to salt bridge formation between peptides were shown to mimic the amphipathic helices of the plasma apolipoproteins. [less ▲]

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See detailThe use of the soil map of Belgium in the assessment of landslide risk
Closson, Damien; Engels, Patrick ULg; Demaret, Xavier

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(3), 165172

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See detailIntérêt du monitoring ambulatoire de la PA de 24 h en pratique quotidienne
Saint-Remy, Annie ULg; Rorive, Georges ULg

in Profil (1993)

L'avènement et les apports incontestablement positifs du monitoringe PA en ambulatoire ne remettent pas en question toutes les connaissances acquises depuis des décennies sur base de la PA mesurée ... [more ▼]

L'avènement et les apports incontestablement positifs du monitoringe PA en ambulatoire ne remettent pas en question toutes les connaissances acquises depuis des décennies sur base de la PA mesurée traditionnellement. On doit encore attendre des directives en matière de diagnostic et de thérapeutique. Une appréciation plus précise du statut tensionnel du patient, du type d'hypertension ainsi que du contrôle de PA pendant le nycthémère par les médications, constituent des avantages potentiels qui devraient sensibiliser les praticiens son utilisation. [less ▲]

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See detailCompte rendu de Aux sources du monachisme colombanien
George, Philippe ULg

in Moyen Age (Le) (1993)

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See detailIsopyoverdin Pp BTP1, a biogenetically interesting novel siderophore from Pseudomonas putida
Jacques, Philippe; Gwose, Inga; Seinsche, Dieter et al

in Natural Product Letters (1993), 3

From the cultures of Pseudomonas putida BTP 1 a siderophore could be isolated which contains the chromophore 2a rather than 1a typical for pyoverdins. Its structure was elucidated by MS, NHR and chemical ... [more ▼]

From the cultures of Pseudomonas putida BTP 1 a siderophore could be isolated which contains the chromophore 2a rather than 1a typical for pyoverdins. Its structure was elucidated by MS, NHR and chemical degradation. This new structural type is of great interest. The currently accepted biogenetic pathway leading to 1a starts from D-Tyr and L-Dab which condense to give the ferribactin chromophore 4. Subsequent ring closure via the -nitrogen of Dab leads to 1a while alternative ring closure via the -nitrogen would yield 2a. It is for the first time that this iso-chromophore has been detected in a Pseudomonas siderophore. Its discovery confirms the assumed intermediacy of ferribactine in the biogenesis of pyoverdins. [less ▲]

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See detailCompte rendu de La Messe de Tournai
George, Philippe ULg

in Moyen Age (Le) (1993)

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See detailExemples d'utilisation de la Carte des Sols de Belgique comme base d'un systeme d'information geographique pour la gestion des terroirs.
Engels, Patrick ULg; Bock, Laurent ULg; Neven, Cécile et al

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(2-3),

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See detailAnalgésie postopératoire par analgésie péridurale autocontrôlée
Joris, Jean ULg

in Douleur et analgésie (1993), 4

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See detailExperts et novices face à un circuit simulé sur ordinateur
Lafontaine, Dominique ULg; Blondin, Christiane ULg; Closset, Jean-Louis ULg

in Education et Recherche (1993), 1

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See detailBasophil releasability in patients with hymenoptera venom allergy.
Radermecker, Maurice ULg; Leclercq, Maryse ULg; Mariz, S. D. et al

in International Archives of Allergy & Immunology (1993), 101(3), 283-7

Basophils in about 15% of subjects allergic to hymenoptera venom do not release histamine in the presence of antigen. Little is known on the basophil releasability in these patients. We therefore measured ... [more ▼]

Basophils in about 15% of subjects allergic to hymenoptera venom do not release histamine in the presence of antigen. Little is known on the basophil releasability in these patients. We therefore measured maximum percent leukocyte histamine release to antigen (Vespula venom), anti-IgE and formylmethionylphenylalanine (FMP) in 39 patients allergic to wasp venom and compared our results according to basophil responsiveness to antigen. Mean maximum percent histamine release was 39, 34 and 22%, respectively, for venom (100 ng/ml), anti-IgE (0.25 microgram/ml) and FMP (10(-4) M). The amount of histamine specifically released by venom correlated significantly with anti-IgE but not with FMP-induced histamine release. Leukocytes were unresponsive to antigen in 10 subjects. The clinical characteristics and anaphylactic symptoms of these patients were not different from those with antigen-responsive cells. Unresponsive leukocytes responded to FMP in all and to anti-IgE in 8 of the 10 subjects. Mean anti-IgE and FMP-induced histamine release were, respectively, lower and higher than those observed with leukocytes responsive to antigen (p < 0.05). In unresponsive basophils, there was a negative correlation between maximum percent anti-IgE and FMP-induced histamine release. We confirm that basophils of a minority of the subjects allergic to Vespula venom do not release histamine in the presence of antigen. The negative correlation between anti-IgE and FMP-induced histamine release in unresponsive basophils may suggest individual differences in the ratio of Fc epsilon RI and FMP receptors on the surface of basophils. [less ▲]

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See detailFlexible Technique for Multiple Organ Procurement in Rats: A Training and Research Tool in Transplantation
D'Silva, M.; Pirenne, J.; Bonnet, Pierre ULg et al

in Microsurgery (1993), 14(5), 342-9

Multiple organ procurement techniques are increasingly popular in many transplant centers. This paper describes a technique for multiorgan unit(s) explantation in rats. The procedure involves in situ ... [more ▼]

Multiple organ procurement techniques are increasingly popular in many transplant centers. This paper describes a technique for multiorgan unit(s) explantation in rats. The procedure involves in situ preliminary dissection, cold perfusion of the thoracic and abdominal organ units as separate procedures, explantation, and finally the ex situ isolation of various organ units as single and/or multiple organ combination units. The procedure is feasible, allows for flexibility in the separation of combination organ units, and is reproducible. The exercise is provided as a training and research tool for clinical and research transplant surgeons. The technique is also presented as an animal model for clinical organ sharing. [less ▲]

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See detailMallarmé, “termite silencieux”. L’auto-liquidation de la poésie
Durand, Pascal ULg

in Romantisme (1993), 81

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See detailLaparoscopy, urology, and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailSoluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia.
Beguin, Yves ULg; Lampertz, S.; De Groote, D. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(12), 2019-2025

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL ... [more ▼]

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL) and evaluated them in relation to clinical and biological parameters of the disease, as well as serum immunoglobulin E (IgE). Compared to 31 normal individuals, 42 CLL patients had increased levels of sCD23 (98.4 +/- 127.7 versus 0.9 +/- 0.3 U/ml, p < 0.001), sIL-2R (6080 +/- 7030 versus 1420 +/- 640 pg/ml, p < 0.001), sTfR (12,100 +/- 11,250 versus 5000 +/- 1050 ng/ml, p < 0.001), and sCD8 (510 +/- 191 versus 234 +/- 89 U/ml, p < 0.001), but normal sCD4 levels. Mean sCD23 levels remained normal in patients with non-Hodgkin's lymphoma (other than small lymphocytic), Hodgkin's disease, hairy cell leukemia, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), multiple myeloma, or solid tumors. Advancing Rai clinical stage was associated with a progressive elevation of sCD23 (p < 0.001), while sCD8 (p < 0.05), sIL-2R (p < 0.001), and sTfR (p < 0.005) were highest in stage 2 patients. Discriminant analysis confirmed the value of soluble receptor determinations in the clinical evaluation of CLL patients. sCD23 correlated with sIL-2R (p < 0.001) and sTfR (p < 0.05) but not with sCD4 or sCD8, and displayed an inverse relationship with serum IgE (NS) and total gamma-globulin (p < 0.05). sIL-2R correlated with sCD23 (p < 0.001), sTfR (p < 0.001), sCD4 (p < 0.01), and sCD8 (p < 0.01). The lymphocyte count correlated with serum lactate dehydrogenase (LDH) (p < 0.05), sCD23 (p < 0.001) and sIL-2R (p < 0.01) but not sTfR, sCD8, or sCD4. Chemotherapy produced consistent reductions of sCD23 levels in two responding patients. We conclude that: (i) sCD23 is considerably elevated in CLL, correlates with the tumor mass and clinical stage, and could be helpful in monitoring these patients; and (ii) sIL-2R, sCD8, and sTfR levels are less specifically increased and could be influenced by other factors such as immune activation and erythropoiesis. [less ▲]

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See detailSurgical Technique for Cardiomyoplasty and Iterative Transthoracic Biopsies in an Experimental Goat Model
Radermecker, M. A.; Fourny, J.; Bonnet, Pierre ULg et al

in European Surgical Research = Europäische Chirurgische Forschung = Recherches Chirurgicales Européennes (1993), 25(2, Mar-Apr), 110-22

Cardiomyoplasty is a new surgical procedure using transformed skeletal muscle to reinforce or substitute for the myocardium. For the purpose of studying surgical technique and investigating basic ... [more ▼]

Cardiomyoplasty is a new surgical procedure using transformed skeletal muscle to reinforce or substitute for the myocardium. For the purpose of studying surgical technique and investigating basic questions, we have developed a model of reinforcement cardiomyoplasty. Herein, we describe anesthetic management, surgical technique, and the technique for iterative transthoracic biopsies. This model has proven to be valuable in several long-term studies involving more than 30 goats. Preliminary data to ascertain the efficacy of the proposed technique are provided. [less ▲]

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See detailDire et écrire pour aller lire en géographie
Partoune, Christine ULg

in Bulletin de la Société Géographique de Liège (1993), 28

Texts, maps and the various documents that we use at school are almost all basically rational and cut off from reality. Before tackling them, it is proposed that we first delve into this "reality" by ... [more ▼]

Texts, maps and the various documents that we use at school are almost all basically rational and cut off from reality. Before tackling them, it is proposed that we first delve into this "reality" by means of fiction. Verbal expression gaines and written games enable us to explore beforehand the mental representation of pupils and provide us with interesting questions for subsequent research. Two approaches of this type are detailed here in order to propose a discussion of their interest and of their relevance. [less ▲]

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See detailLa catalyse enzymatique en milieu organique : potentialités d'utilisation des lipases.
Blecker, Christophe ULg

in Bulletin des Recherches agronomiques de Gembloux (1993), 28(1), 51-85

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See detailLes morphinomimétiques en réanimation
Lamy, Maurice ULg; Joris, Jean ULg; Damas, Pierre ULg et al

in Réan urg (1993), 2(4bis), 488-494

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See detailComparative study of the oxyhaemoglobin dissociation curve of four mammals: man, dog, horse and cattle
Clerbaux, Th; Gustin, Pascal ULg; Detry, B et al

in Comparative Biochemistry and Physiology. A : Comparative Physiology (1993), 106A(4), 687-694

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See detailLaparoscopic supracervical (subtotal) hysterectomy (LASH).
Donnez, Jacques; NISOLLE, Michelle ULg

in Journal of Gynecologic Surgery (1993), 9(2), 91-4

The use of laparoscopically assisted vaginal hysterectomy with or without annexectomy has been widely discussed. We report the technique of laparoscopic supracervical (subtotal) hysterectomy (LASH), which ... [more ▼]

The use of laparoscopically assisted vaginal hysterectomy with or without annexectomy has been widely discussed. We report the technique of laparoscopic supracervical (subtotal) hysterectomy (LASH), which was first performed in 1990. Laparoscopic supracervical hysterectomy was carried out in a series of 36 women. The duration time was 60 min in experienced hands. There were no major complications. The feasibility and low morbidity rate of this laparoscopic approach led us to propose LASH in certain indications, particularly in cases of a uterus with multiple submucosal myomas where hysteroscopic therapy is less successful. [less ▲]

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See detailEvolution du relief au Niger occidental : rôle de la fracturation du socle précambrien et de la formation de pseudo-karsts au sein de la lithomarge et de la couverture sédimentaire
Willems, Luc ULg; Lenoir, François; Levecq, Jean-Marie et al

in Comptes-Rendus de l'Académie des Sciences de Paris (1993), 317(Série II), 97-102

The observation of several forms in the Precambrian formations, in Tertiary and Quaternary deposits brings us to propose a model of topographic evolution mainly generated by a pseudo-karst. This latter is ... [more ▼]

The observation of several forms in the Precambrian formations, in Tertiary and Quaternary deposits brings us to propose a model of topographic evolution mainly generated by a pseudo-karst. This latter is developed in sedimentary deposits and in the lithomargin, in relation with fracturation of the basement. [less ▲]

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See detailComparing measures of poverty and relative deprivation: an example for Belgium
Delhausse, Bernard; Luttgens, Axel; Perelman, Sergio ULg

in Journal of Population Economics (1993), 6

This paper presents three different poverty standards. A first approach takes the disposable income as an indicator of poverty. A second approach uses the Leyden approach. Finally an aggregate index of ... [more ▼]

This paper presents three different poverty standards. A first approach takes the disposable income as an indicator of poverty. A second approach uses the Leyden approach. Finally an aggregate index of deprivation, based on the observation of consumption events, is constructed through a particular econometric procedure proposed by Desai and Shah (1988). These alternative measures are then compared on a sample composed of 6380 Belgian households. Such an analysis can be expected to provide some further insight into the problem of measuring poverty, which has been the subject of a recent controversial debate. [less ▲]

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See detailNew f values in C I and the CNO Abundances in the Sun
Biémont, Emile ULg; Hibbert, A.; Godefroid, M. et al

in Astrophysical Journal (1993), 412

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See detailCombination of oral antidiabetic drugs and insulin in the treatment of non-insulin-dependent diabetes.
Scheen, André ULg; Castillo, M. J.; Lefebvre, Pierre ULg

in Acta Clinica Belgica (1993), 48(4), 259-68

Non-insulin-dependent diabetes mellitus (NIDDM) appears to be an heterogeneous disorder characterized by both relative insulin deficiency and impaired insulin action. The initial management of NIDDM ... [more ▼]

Non-insulin-dependent diabetes mellitus (NIDDM) appears to be an heterogeneous disorder characterized by both relative insulin deficiency and impaired insulin action. The initial management of NIDDM should include patient education, dietary counselling and individualized programs of physical activity. It is only when such measures fail that drug therapy should be considered. Oral drug therapies include sulphonylurea derivatives, biguanides, among which metformin remains the only one commercialized in our country, and alpha-glucosidase inhibitors such as acarbose. However, insulin therapy may be required to achieve adequate glycaemic control in some patients, the so-called secondary failures to oral treatment. The rationale for combining insulin and oral drug therapy derives from a better understanding of the pathophysiology of NIDDM and of the mechanisms of action of the oral drugs available: 1) type 2 diabetic patients are both insulin-deficient and insulin-resistant, thus requiring quite high doses of exogenous insulin; 2) peripheral insulin delivery leads to hyperinsulinaemia which could play a role in the pathogenesis of late diabetic complications; 3) sulphonylureas stimulate insulin release directly into the portal vein and could also potentiate peripheral insulin action; and 4) metformin (by improving glucose metabolism and insulin sensitivity) and alpha-glucosidase inhibitors (by slowing down the digestion of complex carbohydrates and sucrose) are able to reduce the amounts of insulin needed to control postprandial hyperglycaemia. Numerous studies have shown that a combination of insulin and sulphonylurea is more effective than insulin alone in the treatment of patients with NIDDM after secondary failure to oral drugs, leading to better glucose profiles and/or decreased insulin needs. The available data suggest that combination therapy is most beneficial in the diabetic patient who still has residual insulin secretory capacity and that the best scheme comprises an evening injection of lente insulin and the administration of sulphonylureas before meals. Preliminary results suggested that insulin-metformin (when obesity is present) or insulin-acarbose (when post-prandial hyperglycaemia occurs) combinations might offer some favourable features for the treatment of NIDDM patients although these therapeutical approaches still require adequate evaluation in further controlled studies. The additional cost of such combined therapy should be weighed against the potential advantages of better metabolic control. [less ▲]

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See detailThyrotropin-releasing hormone and epidermal growth factor induce human prolactin expression via identical multiple cis elements
Berwaer, Monique; Peers, Bernard ULg; Nalda, Asuncion M et al

in Molecular & Cellular Endocrinology (1993), 92(1), 1-7

Pituitary GH3 cells were transfected with different deletion mutants of the human prolactin (hPRL) promoter fused to the CAT reporter gene. The proximal region (-250 to -42) was sufficient to confer ... [more ▼]

Pituitary GH3 cells were transfected with different deletion mutants of the human prolactin (hPRL) promoter fused to the CAT reporter gene. The proximal region (-250 to -42) was sufficient to confer stimulation by both thyrotropin-releasing hormone (TRH) and epidermal growth factor (EGF). Further deletion analyses demonstrated the importance of the three proximal Pit-1 binding sites in this response. However, Pit-1 binding oligonucleotides confer neither TRH nor EGF induction to a linked neutral promoter, suggesting that other elements might be involved. We have previously shown that sequence A (-115 to -85) is needed together with Pit-1 binding sites for full cyclic AMP response of hPRL-CAT. Mutation of this sequence strongly affects TRH and EGF induction. On the other hand, three copies of sequence A confer both TRH and EGF response to a linked neutral promoter. In conclusion, although TRH and EGF activate mostly different intracellular pathways, they mediate transcriptional induction of the hPRL promoter via identical cis elements. [less ▲]

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See detailEffect of androgen treatmen on fear reactions in ewes
Vandenheede, Marc ULg; Bouissou, M. F.

in Hormones & Behavior (1993), 27

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See detailStructure of the apolipoprotein A-IV/lipid discoidal complexes: an attenuated total reflection polarized Fourier transform infrared spectroscopy study.
Lins, Laurence ULg; Brasseur, Robert ULg; Rosseneu, M. et al

in Biochimica et Biophysica Acta (1993), 1149(2), 267-77

Discoidal lipid particles were prepared from a reaction mixture containing apo A-IV and dimyristoylphosphatidylcholine (DMPC) or dipalmitoylphosphatidylcholine (DPPC) in the molar ratio of 185:1 (lipid ... [more ▼]

Discoidal lipid particles were prepared from a reaction mixture containing apo A-IV and dimyristoylphosphatidylcholine (DMPC) or dipalmitoylphosphatidylcholine (DPPC) in the molar ratio of 185:1 (lipid/protein). The complexes were isolated by gel filtration and characterized in terms of composition and size. Infrared attenuated total reflection spectroscopy was used to estimate the secondary structure of apolipoprotein A-IV and the orientation of its amphipathic alpha-helices with respect to the lipid hydrocarbon chains. In addition, infrared spectra were analyzed in terms of the conformation and organization of different regions of the lipid molecules in the particles. This approach has been applied successfully to reconstituted HDL particles prepared from a reaction mixture containing DPPC and apo A-I in the molar ratio of 150:1 (Wald, J.H., Goormaghtigh, E., De Meutter, J., Ruysschaert, J.M. and Jonas, A. (1990) J. Biol. Chem. 265, 20044-20050). Apo A-IV helicity increased for the protein bound to DMPC or DPPC but the increase was more pronounced for the apo A-IV/DMPC particles. In both complexes, the alpha helical amphipathic segments of the protein were parallel to the lipid acyl chains and no significant modification of the overall organization of the lipid molecules in the lipid bilayer was observed. The presence of apo A-IV seems only to affect the conformation of the lipid hydrocarbon chains in close contact with the protein in the discoidal particles. [less ▲]

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See detailApports récents de la génétique dans les maladies inflammatoires intestinales
Louis, Edouard ULg; Belaiche, Jacques ULg; Franchimont, D. et al

in Acta Clinica Belgica (1993), 48(6), 383-91

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the ... [more ▼]

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the concept of genetic heterogeneity. This new concept leads us to try to classify different forms of inflammatory bowel disease and could have in the future an impact on the prevention, the follow up and the treatment of these diseases. [less ▲]

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See detailEngery-filtering transmission electron microscopy of biological specimens.
de Bruijn, W. C.; Sorber, C. W.; Gelsema, E. S. et al

in Scanning Microscopy (1993), 7(2), 693-708709

By energy-filtering transmission electron microscopy (EFTEM) electrons can be separated by their energy losses. An electron-energy filter, added to the microscope column allows the measurement of the ... [more ▼]

By energy-filtering transmission electron microscopy (EFTEM) electrons can be separated by their energy losses. An electron-energy filter, added to the microscope column allows the measurement of the energy distribution of transmitted electrons that have lost energy (< 2,000 eV, with an energy resolution of approximately 1 eV). These filtered electrons, recorded either as a spectrum or as an image, are composed of two parts superimposed on top of each other: (a) the unspecific energy-loss population (= the continuum) and (b) the specific element-related energy-loss population (= the edges). At the edges, electron data in spectra and images are mathematically processed, to obtain the desired element-related net-intensity values or images. These data are related to the total transmitted electron intensity, from the zero- and low-loss spectral region giving the relative spectralor image intensity rations ((S)R*x, (I)R*x), which can be related to the element concentration. The acquisition of the zero-loss and low-loss data is hampered by the restricted dynamic range of the TV camera. By improvements through the introduction of calibrated attenuation filters in the optical path to the TV-camera, more reliable values for (S)R*x and (I)R*x can be acquired. By addition of Bio-standards adjacent to the tissue, a "known" and "unknown" concentration of the element present in the same ultrathin section and the "bias" in the concentration estimation, can be obtained. Some practical examples are given for the estimation of the iron cencentration in siderosomes, boron in melasosomes and calcium in calcium oxalate monohydrate crystals. [less ▲]

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See detailCharacterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.
Peers, Bernard ULg; Johnson, T.; Ferreri, K. et al

in Molecular Endocrinology (1993), 7(10), 1275-83

The endocrine pancreas consists of several differentiated cell types that are distinguished by their selective expression of peptide hormones such as insulin, glucagon, and somatostatin. Although a number ... [more ▼]

The endocrine pancreas consists of several differentiated cell types that are distinguished by their selective expression of peptide hormones such as insulin, glucagon, and somatostatin. Although a number of homeobox-type factors have been proposed as key regulators of individual peptide genes in the pancreas, their cellular distribution and relative abundance remain uncharacterized. Also, their overlapping DNA binding specificities have further obscured the regulatory functions these factors perform during development. In this report we characterize a novel homeobox-type somatostatin transactivating factor termed STF-1, which is uniformly expressed in cells of the endocrine pancreas and small intestine. The 283-amino acid STF-1 protein binds to tissue-specific elements within the somatostatin promoter and stimulates somatostatin gene expression both in vivo and in vitro. Remarkably, STF-1 comprises the predominant tissue-specific element-binding activity in nuclear extracts from somatostatin-producing pancreatic islet cells, suggesting that this protein may have a primary role in regulating peptide hormone expression and specifying endocrine cell lineage in the developing gut. [less ▲]

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See detailFacteurs écologiques de production du frêne en Condroz et productivité des stations potentielles
Claessens, Hugues ULg; Thibaut, André; Rondeux, Jacques ULg

in Cahiers Forestiers de Gembloux (1993), 11

The aim of the present study is to correlate site variables with measured site index restricted to pure even-aged or nearly even-aged stands of ash. The site evaluation has been made through 81 ... [more ▼]

The aim of the present study is to correlate site variables with measured site index restricted to pure even-aged or nearly even-aged stands of ash. The site evaluation has been made through 81 experimental plots distributed throughout the Condroz under a wide range of ecological conditions and types of soils. Site index (top height at 50 years) was measured on each plot using tree height-age relationship according to an appropriate methodology [THIBAUT and al., 1992]. In order to appreciate the relative importance of all the observed or measured site factors, plots were grouped in three major groups related to site conditions and defined as follows : alluvial and colluvial sites, flats and slopes either on deep muddy soils or on stony soils. Topographic position, soil depth and soil drainage conditions had the highest correlation with measured site index. These variables and the three site groups have been successfully used as independent variables in a regression model that is an interesting tool for evaluating productive potential of a site for ash even devoid of trees. [less ▲]

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See detailHigh-Grade Pleomorphic T Cell Lymphoma with Restricted Involvement of Skin and Bone Marrow
Gautier, M. S.; Pierard, Gérald ULg; Andrien, Francine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1993), 186(4), 287-9

Pleomorphic T cell lymphoma of the medium to large cell type expressing CD30 antigen is a most aggressive peripheral T cell lymphoma. Currently, there is no satisfactory treatment available for this ... [more ▼]

Pleomorphic T cell lymphoma of the medium to large cell type expressing CD30 antigen is a most aggressive peripheral T cell lymphoma. Currently, there is no satisfactory treatment available for this neoplasm. We report the case of a woman with prominent skin and bone marrow involvement without detectable lymph node localization. This unusual presentation of disease responded well to polychemotherapy combined with autologous bone marrow transplantation. [less ▲]

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See detailHigh Resolution Frequency Analysis as applied to the singing voice
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Folia Phoniatrica (1993), 45

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the ... [more ▼]

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the resonators. This is observed especially on a low fundamental, and it is acquired through technical skill and experience (2)Observation of the vibrato, which, isolated from the clinical study, regarding only its graphic presentation, could habe been interpreted as "abnormal". [less ▲]

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See detailTemperature, air humidity and air pollution levels in breeding pig houses
Nicks, Baudouin ULg; Canart, B.; Vandenheede, Marc ULg

in Pigs News and Information (1993), 14(2), 77-78

A study was undertaken to provide practical information concerning the frequency of temp. and RH measurements required to obtain a good estimate of their averages and of their daily variations, and to ... [more ▼]

A study was undertaken to provide practical information concerning the frequency of temp. and RH measurements required to obtain a good estimate of their averages and of their daily variations, and to determine the relationships between ammonia, carbon dioxide and bacterial concn in a pig house. Measurements were made in 9 artificially ventilated farrowing or weaner houses with slatted floors. Temp. and RH were measured every 20 min for 7 d. Sensors were placed inside buildings in the middle of the houses, 0.8 m above floor level, and outside the buildings. Data were recorded using a datalogger. Ammonia and carbon dioxide concn were measured using 8 h Gastec diffusion tubes. Three readings were taken in the same location at 2-day intervals. The airborne bacterial concn was measured with a 6-stage Andersen sampler. Bacteria colony forming particles (BCFP) were collected by impacting onto agar-filled petri dishes which are placed in an incubator for 24 h prior to counting the colonies formed. Results are discussed, indicating no significant correlation between the 3 measures of pollution (NH3 and CO2 concn, BCFP levels) despite careful microclimate control. [less ▲]

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See detailSub-mesoscale Air-sea Interactions
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Journal of Marine Systems (1993), 4(2-3),

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See detailMeasurement of Total Respiratory Impedance in Dogs by the Forced Oscillation Technique
Clercx, Cécile ULg; Gustin, Pascal ULg; Landser, F. J. et al

in Veterinary Research Communications (1993), 17(3), 227-239

The resistance (Rrs) and reactance (Xrs) of the total respiratory system were determined at various frequencies in 14 healthy conscious beagle dogs. A pseudorandom noise pressure wave was produced at the ... [more ▼]

The resistance (Rrs) and reactance (Xrs) of the total respiratory system were determined at various frequencies in 14 healthy conscious beagle dogs. A pseudorandom noise pressure wave was produced at the nostrils of the animals by means of a loudspeaker adapted to the nose by a tightly fitting mask. A Fourier analysis of the pressure and flow signals yielded mean Rrs and Xrs, over 16 s, at frequencies from 2 to 26 Hz. The influence of the posture of the dog, the position of its head, the linearity of the respiratory system, the reproducibility of the method and the effects of upper and lower airway obstructions were studied. In sitting and standing healthy dogs with the head in the extended position, Rrs values increased progressively with frequency from 5.4 +/- 0.4 (SEM) cmH2O L-1s at 6 Hz up to 8.8 +/- 0.7 cmH2O L-1s at 26 Hz, the mean resonant frequency being 6.1 +/- 0.5 Hz. No significant differences were observed between measurements performed with the head in the normal or the extended position. In a recumbent posture, all Rrs values were increased but Rrs was still dependent on the frequency in the same way (7.1 +/- 0.7 cmH2O L-1s at 6Hz up to 10.0 +/- 0.5 cmH2O L-1s at 26 Hz). Tracheal compression also induced higher Rrs values without changes in the frequency dependence or in the resonant frequency. In anaesthetized dogs, airway obstruction was induced by inhalation of histamine (4 mg/ml for 5 min; the Rrs values tended to decrease with increasing frequency, and the resonant frequency was markedly increased [less ▲]

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See detailTabagisme et poids corporel.
PAQUOT, Nicolas ULg; SCHEEN, André ULg; Lefebvre, P.

in Médecine et Hygiène (1993), 51

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See detailSyngeneic Grafting of Adult Rat Drg-Derived Schwann Cells to the Injured Spinal Cord
Martin, Didier ULg; Schoenen, Jean ULg; Delree, P. et al

in Brain Research Bulletin (1993), 30(3-4), 507-14

A subdural inflatable micro-balloon was used to induce closed traumatic contusion to adult rat spinal cord. This spinal cord injury model was associated with reproducible and graded neurological deficits ... [more ▼]

A subdural inflatable micro-balloon was used to induce closed traumatic contusion to adult rat spinal cord. This spinal cord injury model was associated with reproducible and graded neurological deficits and histopathological alterations. At various delays after injury, transplantations of syngeneic adult cultured dorsal root ganglion-derived Schwann cells were performed into the spinal cord lesion. The transplants were well integrated and reduced the microcystic posttraumatic cavitation as well as the gliosis. Schwann cells transplants were invaded by numerous regenerating neurites most of which, based upon their neurotransmitter contents, seem to originate from the dorsal root ganglion. [less ▲]

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See detailSubjective shortening in human's memory for stimulus duration
Wearden, J. H.; Ferrara, André ULg

in Quarterly Journal of Experimental Psychology (1993), 46B(2), 163-186

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See detailEvolution de la situation des mammifères sauvages en Région wallonne au cours de décennie 1983-1992
Libois, Roland ULg

in Cahiers d'Ethologie (1993), 13(1), 77-92

During the last ten years, the evolution of the status of the mammal fauna of Wallony (southern part of Belgium) can be characterized by four main trends: i- enforcement of a better legal protection ii ... [more ▼]

During the last ten years, the evolution of the status of the mammal fauna of Wallony (southern part of Belgium) can be characterized by four main trends: i- enforcement of a better legal protection ii- arrival of at least four new species: coypu, raccoon, raccon-dog and American mink iii- restoration of badger numbers following the efficient control of rabies iv- increase of anthropophilic or game species (stone marten, ungulates). Unfortunately, the most threathened species (otter, horseshoe bats, barbastella) did not recover. [less ▲]

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See detailEvaluation isocinétique des genoux ligamentaires en pré et postopératoire
Croisier, Jean-Louis ULg; Delcour, J. P.; Dupont, Géraldine ULg et al

in Lettre de Médecine Physique et de Réadaptation (1993), 29

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See detailWavenumbers and Oscillator Strengths for n1,3L - n'1,3L' (2 <n<50) Rydberg transitions of neutral Helium
Biémont, Emile ULg; Quinet, Pascal ULg

in Bulletin de la Société Royale des Sciences de Liège (1993), 62(5-6), 373-398

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See detailLes pseudo-asthmes. Tout ce qui siffle n'est pas asthme.
CORHAY, Jean-Louis ULg; Bury, Thierry ULg; Cabut, Christian ULg et al

in Revue Médicale de Liège (1993), 48(3), 137-42

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See detailConditional heteroscedasticity in pacific-basin stock market returns
Corhay, Albert ULg; Tourani-Rad, Alireza

in Research in International Business and Finance (1993), 10

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return ... [more ▼]

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return-generating models which empirically fit the data are processes with conditional heteroscedastic innovations. Particularly, the generalized autoregressive conditional heteroscedastic GARCH(1,1) process turns out to be the best in most cases. [less ▲]

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See detailLa descendance de celt. *AKARNOS en wallon
Boutier, Marie-Guy ULg

in Revue de Linguistique Romane (1993)

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See detailPotato chloroplasts express an intron-encoded maturase-like polypeptide
du Jardin, Patrick ULg; Portetelle, Daniel ULg; Harvengt, L. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1993), 101

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