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See detailIl libro di messer Tristano («Tristano Veneto»).
Moreno, Paola ULg

in Moyen Age (Le) (1997)

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See detailImproved emulsifying and foaming of whey proteins after enzymic fat hydrolysis
Blecker, Christophe ULg; Paquot, Michel ULg; Lamberti, I. et al

in Journal of Food Science (1997), 62(1), 48-

In an effort to improve emulsifying and foaming of sweet whey and whey protein concentrate, we studied the hydrolysis of the residual fat in these preparations with a sn 1,3 specific lipase. This ... [more ▼]

In an effort to improve emulsifying and foaming of sweet whey and whey protein concentrate, we studied the hydrolysis of the residual fat in these preparations with a sn 1,3 specific lipase. This enzymatic lipolysis would convert almost all triglycerides into mono- and diglycerides which have strong surface-active properties. Therefore, the emulsifying and foaming capacities of such modified whey products should be increased in comparison with native products, as shown by results presented at both neutral pH and those similar to a salad dressing emulsion. It was also demonstrated that emulsions and foams formed with lipase-treated whey preparations were more shelf-stable. [less ▲]

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See detailSynthesis of resorcinol-formaldehyde aeroels by the freeze-drying methods
Mathieu, Bernard; Michaux, Bernard; Pirard, René ULg et al

in Annales de Chimie Science des Materiaux (1997), 22

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See detailPenicillin-binding proteins. Wall peptidoglycan assembly and resistance to penicillin: facts, doubts and hopes
Ghuysen, Jean-Marie ULg; Charlier, Paulette ULg; Coyette, Jacques ULg et al

in International Journal of Antimicrobial Agents (1997), 8(1), 45-60

As the protein sequence and structure databases expand, the relationships between proteins, the notion of protein superfamily, and the driving forces of evolution are better understood. Key steps of the ... [more ▼]

As the protein sequence and structure databases expand, the relationships between proteins, the notion of protein superfamily, and the driving forces of evolution are better understood. Key steps of the synthesis of the bacterial cell wall peptidoglycan are revisited in light of these advances. The reactions through which the D-alanyl-D-alanine depeptide is formed, utilized, and hydrolyzed and the sites of action of the glycopeptide and β-lactam antibiotics illustrate the concept according to which new enzyme functions evolve as a result of tinkering of existing proteins. This occurs by the acquisition of local structural changes, the fusion into mul-timodular polypeptides, and the association into multiprotein complexes. [less ▲]

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See detailIn search of the Latin American Faulkner
Vanden Berghe, Kristine ULg

in Target : International Journal of Translation Studies (1997), 9(2), 399-400

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See detailRadiotherapie externe focalisee apres resection de metastase cerebrale unique: etude prospective de phase I-II
Zouhair; COUCKE, Philippe ULg; Douglas, Pelham et al

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (1997), 1

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See detailAlternative techniques of hysterectomy.
NISOLLE, Michelle ULg; Donnez, Jacques

in New England Journal of Medicine [=NEJM] (1997), 336(4), 291-2

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See detailPour l’optimisation de la stratégie thérapeutique dans la maladie osseuse de Paget
Reginster, Jean-Yves ULg; Gennari, C; Hosking, DJ et al

in Revue du Rhumatisme (1997), 64(4), 221-223

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See detailPotential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells
Grignet, Christine ULg; Calberg-Bacq, Claire-Michelle

in Gene Therapy (1997), 4

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See detailTechnique for long-term catheterization of large abdominal vessels in growing cattle.
Hornick, Jean-Luc ULg; Istasse, Louis ULg

in Contemporary Topics in Laboratory Animal Science (1997), 36(2), 66-8

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See detailSquare cells in gravitational and capillary thermoconvection
Regnier, Vincent; Dauby, Pierre ULg; Parmentier, P. et al

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 55(6), 6860-6865

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See detailOnset Time of Neuromuscular Block and Intubating Conditions: Influence of Different Stimulation Patterns
Hans, Pol ULg; Dewé, Walthère ULg; Albert, Adelin ULg

in Acta Anaesthesiologica Belgica (1997), 48(1), 15-21

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See detailOrigine sociale et réussite scolaire : un modèle en Chaîne de Markov estimé sur données individuelles belges
Donni, Olivier; Lejeune, Bernard ULg

in Recherches Economiques de Louvain (1997), 63(4), 421-446

Cet article étudie les relations entre l'origine socio-économique des élèves belges et leur parcours scolaire primaire et secondaire. Il repose sur l'hypothèse que le parcours scolaire des élèves peut ... [more ▼]

Cet article étudie les relations entre l'origine socio-économique des élèves belges et leur parcours scolaire primaire et secondaire. Il repose sur l'hypothèse que le parcours scolaire des élèves peut être décrit par un processus de Markov. Sur la base d'un échantillon transversal d'un millier d'enfants, en fonction de variables socio-économiques et pour chacune des années de scolarité obligatoire, les probabilités individuelles de poursuivre un parcours scolaire ''normal'', c.-à-d. sans redoublement ni relégation dans une filière de second choix, sont estimées. Nos résultats montrent que derrière les substantiels taux agrégés de redoublement qui caractérisent le système scolaire belge se cachent en fait de profondes inégalités sociales. [less ▲]

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See detailLesions observed on stranded seabirds along the Belgian coast from 1992 to 1995
Jauniaux, Thierry ULg; Brosens, L.; Coignoul, Freddy ULg

in ICES Journal of Marine Science (1997), 54(4), 714-717

From 1992 to 1995, dead seabirds found on Belgian beaches were collected and various tissues of 241 birds were sampled for histopathological, bacteriological, parasitological, and toxicological ... [more ▼]

From 1992 to 1995, dead seabirds found on Belgian beaches were collected and various tissues of 241 birds were sampled for histopathological, bacteriological, parasitological, and toxicological investigations. The most common species examined was the guillemot (Uria aalge). Necropsies revealed cachexia (severe emaciation), acute haemorrhagic gastro-enteropathy and oil contamination in many of these birds. Statistical analyses were performed in order to explore correlations of these with biological parameters such as age, sex, and origin (pelagic or non-pelagic). The pelagic origin of seabirds were associated with the three main findings. Oil contamination was associated with acute gastro-enteropathy and cachexia, and cachexia was more prevalent among juveniles. Finally, cachexia and acute gastro-enteropathy were strongly associated. It is possible that oiled pelagic seabirds become cachectic and die of acute gastro-enteropathy. (C) 1997 International Council for the Exploration of the Sea. [less ▲]

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See detailGalectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue.
Fernandez, P. L.; Merino, M. J.; Gomez, M. et al

in Journal of Pathology (The) (1997), 181(1), 80-6

Galectin-3 is a 31 kD beta-galactoside-binding lectin which is expressed by several types of non-neoplastic and neoplastic cells and which may be involved in cell-extracellular matrix interactions. An ... [more ▼]

Galectin-3 is a 31 kD beta-galactoside-binding lectin which is expressed by several types of non-neoplastic and neoplastic cells and which may be involved in cell-extracellular matrix interactions. An immunohistochemical study has been made of the expression of galectin-3, as well as its ligand, laminin, in a spectrum of benign and malignant thyroid neoplasms and in some non-neoplastic conditions. Immunohistochemistry with anti-human recombinant galectin-3 antibody showed consistent, intense positivity in the neoplastic cells of 18 cases of papillary carcinoma and less intense staining in the five anaplastic carcinomas studied. In addition, two out of three poorly differentiated carcinomas, three out of six medullary carcinomas, and four out of eight follicular carcinomas had less intense or focal positivity. One case of Hurthle cell carcinoma showed scattered strongly positive cells. Eight follicular adenomas, three hyperplastic nodules, five nodular goitres, and normal thyroid tissue were negative. Galectin-3 mRNA expression was also evaluated in three of the papillary carcinomas, two follicular adenomas, and one hyperplastic nodule with matched normal tissue. Northern blot analysis demonstrated mRNA overexpression in the three cases of papillary carcinomas, whereas normal and benign tissues were negative. Laminin distribution in neoplastic and non-neoplastic tissue varied with architectural patterns but did not correlate with galectin-3 immunohistochemical expression. We conclude that expression of galectin-3 is limited to inflammatory foci in normal and benign thyroid tissue and is a phenotypic feature of malignant thyroid neoplasms, especially papillary carcinomas. [less ▲]

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See detailNew Primers For The Polymerase Chain Amplification Of Cpdna Intergenic Spacers In Phaseolus Phylogeny
Fofana, B.; Harvengt, L.; Baudoin, Jean-Pierre ULg et al

in Belgian Journal of Botany (1997), 129(2),

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See detailHypochlorous acid activates NF-kappaB transcription factor in T lymphocytes
Schoonbroodt, Sonia; Legrand-Poels, Sylvie ULg; Best-Belpomme, Martin et al

in Biochemical Journal (1997)

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See detailCaractéristiques microbiologiques et organoleptiques du nététu du commerce.
N'dir, B.; Gningue, B. D.; Keita, N. G. et al

in Cahiers Agricultures (1997), 6

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See detailIn vitro modulation of keratinocyte attachment to dentin by minocycline
Van Heusden, Alain ULg; Rompen, Eric ULg; Lapière, Charles

in Journal of Dental Research (1997), 76

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See detailLa bryoflore d'une forêt alluviale fonctionnelle: la réserve naturelle rhénane de l'Ile de Rhinau (Bas-Rhin, France)
Klein, J. P.; Siebel, H.; Vanderpoorten, Alain ULg

in Mitteilungen des Badischen Landesvereins für Naturkunde und Naturschutz (1997), 16

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See detailLes strychnos africains et leurs alcaloïdes
Delaude, Clément ULg; Delaude, Lionel ULg

in Bulletin de la Société Royale des Sciences de Liège (1997), 66(4), 183-286

In the Greek Antiquity, the term strychnos was first coined to describe various toxic Solanacae. Nowadays, the genus Strychnos created by Linnaeus in 1753 is the numerically most important genus from the ... [more ▼]

In the Greek Antiquity, the term strychnos was first coined to describe various toxic Solanacae. Nowadays, the genus Strychnos created by Linnaeus in 1753 is the numerically most important genus from the Loganiaceae family and comprises 196 species growing in the warm regions of Asia (58 species), America (64) and Africa (75). Species on the three continents are almost totally segregated. Only Strychnos potatorum is common to Asia and Africa. The toxicity of Strychnos was empirically well-known from time immemorial. Inhabitants of South-Eastern Asia and India had an ancestral knowledge of Strychnos nux vomica, whose deadly poisonous seeds were later imported and marketed in Europe to kill rodents and small predators. Concentrated extracts from Amazonian Strychnos, known as curares, are also remarkable hunting poisons, used by South American Indians. Accordingly, modern scientific investigations of Strychnos and their alkaloids started with Asian or American species used as traditionnal poisons. Strychnine was the first alkaloid found in Strychnos. It was isolated from Asian S. nux vomica in 1818, but its structure was fully elucidated only in the 1950s. Meanwhile, various curarizing alkaloids from American Strychnos were identified. Based on these early results, Strychnos alkaloids were initially classified according to their geographical origin. Asian Strychnos were assumed to contain strychnine and related compounds, whereas curarizing ammonium salts were associated with American Strychnos. African species were assimilated to their Asian counterparts and deemed of less interest. During the last three decades, however, systematic screening of African Strychnos has revealed the presence of numerous, varied alkaloids in these plants and demonstrated that the correlation between geographical distribution and alkaloid content was erroneous. Presently, 47 African species have been investigated and their alkaloids analyzed, significantly more than Asian and American materials (about 10 and 20 species, respectively). In this review, we present the alkaloids isolated so far from African Strychnos. 309 structures are listed and sorted according to their molecular weight, the most useful index key in modern research based on mass spectrometry. [less ▲]

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See detailZiemniak w Belgii
Burny, Philippe ULg; Gazinski, Benon

in Rolnicze abc (1997), 6(83), 20

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See detailFibres alimentaires chez le chien : influence de l'incorporation de pulpes de betterave ou de chicorée sur la digestibilité des nutriments et les concentrations plasmatiques de plusieurs métabolites
Diez, Marianne ULg; Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg et al

in Revue de Médecine Vétérinaire (1997), 148

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres ... [more ▼]

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres fécaux, la digestibilité des principaux nutriments et plusieurs paramètres biochimiques (glucose, insuline, azote alpha-aminé, urée, cholestérol et triglycérides) mesurés à jeun ou pendant six heures après le repas chez huit chiens adultes en bonne santé. Les régimes enrichis en pulpes ont entraîné une augmentation significative de l'excrétion fécale totale, de l'excrétion de MS dans les matières fécales, une diminution de la teneur en MS des fèces ainsi qu'une diminution des coefficients de digestibilité des principaux nutriments. Le régime contenant la pulpe de betterave a entraîné une diminution de la glycémie à jeun, de l'insulinémie et des concentrations en triglycérides postprandiales, des concentrations en urée et en cholestérol mesurées avant et après le repas. Le régime contenant la pulpe de chicorée a provoqué une diminution de l'insulinémie postprandiale, des concentrations en urée et en cholestérol à jeun et après le repas. Ces deux types de pulpes, semblables par leur composition, induisent les mêmes types d'effets sur les paramètres fécaux et la digestibilité des nutriments, mais les effets systémiques sont plus importants lors de la distribution de pulpes de betterave. [less ▲]

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See detailSequence Analysis of the Bovine Herpesvirus Type 1 Genes Homologous to the DNA Polymerase (Ul30), the Major DNA-Binding Protein (Ul29) and Icp18.5 Assembly Protein (Ul28) Genes of Herpes Simplex Virus
Meyer, Gilles; Vlcek, C.; Paces, V. et al

in Archives of Virology (1997), 142(1), 89-102

The nucleotide sequence of a 10.5 kb region (map position 0.332 to 0.410) of bovine herpesvirus type 1 (BHV-1) was determined. This region contained three open reading frames (ORFs) homologous to herpes ... [more ▼]

The nucleotide sequence of a 10.5 kb region (map position 0.332 to 0.410) of bovine herpesvirus type 1 (BHV-1) was determined. This region contained three open reading frames (ORFs) homologous to herpes simplex virus DNA polymerase catalytic subunit (DNApol, UL30), major DNA-binding protein (MDBP, UL29) and ICP18.5 assembly protein (ICP18.5, UL28). The BHV-1 DNApol. MDBP and ICP18.5 ORFs were 1246, 1203 and 826 amino acids long with a calculated molecular mass of 134.2 kDa, 124.4 kDa and 86.9 kDa, respectively. They showed a high homology with alphaherpesvirus homologs despite large differences in the G + C content of the UL30-UL28 segment ranging from 44.4% for varicella zoster virus to 71.5% for BHV-1. Particularly well conserved among Alphaherpesvirinae are the putative functional domains of the DNApol and MDBP proteins which are discussed. Phylogenetic analysis revealed that BHV-1 clustered in the Varicellovirus genus with the animal D-type viruses. In this group, the BHV-1 position was shown to vary according to the investigated genes. Indeed, pseudorabies virus clustered with BHV-1 in the DNApol tree but with equine herpesvirus 1 in the ICP18.5 tree. [less ▲]

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See detailUltrastructural nucleolar alterations induced by an ametantrone/polyr(A-U) complex.
Thiry, Marc ULg; Jamison, J. M.; Gilloteaux, J. et al

in Experimental Cell Research (1997), 236(1), 275-84

In the present study we examined the ultrastructural modifications as well as the precise distribution of DNA and RNA in RT4 cell nucleoli following a 3-h exposure to nontoxic or toxic doses of ... [more ▼]

In the present study we examined the ultrastructural modifications as well as the precise distribution of DNA and RNA in RT4 cell nucleoli following a 3-h exposure to nontoxic or toxic doses of ametantrone (AMT), poly(adenylate-uridylate) (polyr(A-U), or an AMT/polyr(A-U) combination. While distribution of nucleic acids within the various nucleolar components is not modified following all treatments, the nucleoli exhibit several ultrastructural changes: redistribution of the nucleolar components, decrease in the number of fibrillar centers, and increase in the size of the fibrillar centers. The relative frequencies of the test agents to induce the apparition of nucleoli of compact type are AMT/polyr(A-U) > AMT approximately polyr(A-U) > sham-treated, while the abilities of the test agents to induce the nucleolar segregation are AMT/polyr(A-U) approximately AMT > polyr(A-U) > sham-treated cells. These ultrastructural changes are characteristics of drugs that intercalate into DNA and inhibit rDNA transcription as well as rRNA processing and release of nascent preribosomes from the nucleolus. [less ▲]

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See detailInfluence of cholesterol on survival after stroke. Cholesterol may be marker of inflammation.
VALDES SOCIN, Hernan Gonzalo ULg

in BMJ (Clinical Research ed.) (1997), 315(7116), 1159

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See detailFeeding of the sparid fish Sarpa salpa in a seagrass ecosystem: Diet and carbon flux
Havelange, S.; Lepoint, Gilles ULg; Dauby, Patrick ULg et al

in Marine Ecology (1997), 18(4), 289-297

In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ... [more ▼]

In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ratios were measured in fish muscle and potential food sources (algae, P. oceanica leaf and its epiphytes) to determine their relative contribution to the fish diet. S. salpa has an age-related mixed diet: juveniles are plankton feeders, young, sub-adults and adults are herbivorous, and, the older the individuals, the higher the relative contribution of P. oceanica to the diet. Our results and former studies of carbon stocks and fluxes in the P. oceanica bed of Revellata Bay have enabled an estimation of the general impact of S. salpa grazing on infralittoral communities: the studied species consumes 24 g C.m-2.a(-1) from P. oceanica leaf, 4.8 from epiphytes and 13 from epilithic algae. The fish net production and biomass turnover in that zone have been estimated to be 1.2 g C.m(-2).a(-1) and 1.5 a(-1), respectively. [less ▲]

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See detailQtl Mapping to Qtl Cloning: Mice to the Rescue
Georges, Michel ULg

in Genome Research (1997), 7(7), 663-665

With the availability of dense, highly informative marker maps, it has recently become feasible to map genes (Quantitative Trait Loci or QTL) accounting for part of the heritability of continuously ... [more ▼]

With the availability of dense, highly informative marker maps, it has recently become feasible to map genes (Quantitative Trait Loci or QTL) accounting for part of the heritability of continuously distributed traits in experimental crosses as well as outbred populations. QTL mapping efforts have almost invariably revealed a limited number of loci with effects of a magnitude clearly departing from the predictions of the infinitesimal model (a model introduced to facilitate mathematical treatment of quantitative traits rather than to truly reflect their underlying biology). As most experimental designs would have limited detection power, which could lead to an overestimation of the identified gene effects, interpretation of results from QTL mapping studies must be viewed with caution. However, numerous independent confirmation studies leave little doubt that most quantitative traits indeed involve a limited suite of loci with major effect. This assertion seems to hold not only for QTL mapped in crosses between divergent lines, but—more importantly—for QTL segregating in outbred populations as well (for review, see Paterson 1995). Despite the sometimes unexpected magnitude of the identified QTL effects, the lack of simple correspondence between genotype and phenotype in complex trait analysis precludes the unambiguous identification of recombinant individuals. This may limit the achievable mapping resolution of QTL, posing a serious threat to the efficacy of positional (candidate) cloning for QTL considerably. QTL mapping efforts, whether performed in pedigrees or by exploiting linkage disequilibrium, are likely to leave geneticists with a portion of the genome that contains tens if not hundreds of genes and many DNA sequence polymorphisms to examine to identify the causal variant. Mutations causing monogenic inherited diseases are often destructive enough to leave little doubt about their causality. Even if the functional consequences of such mutations were less transparent, demonstration of a perfect correspondence between genotype and … [less ▲]

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See detailLarga existencia y breve desaparición: el adiós de una revista cultural.
Vanden Berghe, Kristine ULg

in América. Cahiers du CRICCAL (1997), 18(II), 587-600

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See detailComment je traite les hypertensions réfractaires
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1997), 52(1), 2-6

L'hypertension artérielle réfractaire représente 10% des hypertensions artérielles traitées. La définition, arbitraire, consiste en la persistance de valeurs de pression artérielle au-delà de 140/90 mmHg ... [more ▼]

L'hypertension artérielle réfractaire représente 10% des hypertensions artérielles traitées. La définition, arbitraire, consiste en la persistance de valeurs de pression artérielle au-delà de 140/90 mmHg malgré une trithérapie antihypertensive dont un diurétique. Ce traitement a été administré à dose optimale pendant une durée suffisante. La reconnaissance des vraies hypertensions réfractaires est la première démarche diagnostique (bonne mesure de la pression artérielle et authenticité de l'augmentation de pression). Ensuite il convient de rechercher une non-observance, une forme secondaire d'hypertension artérielle ou encore une résistance thérapeutique liée à un excès de poids et à un hyperinsulinisme. Cette démarche permettra de proposer un schéma thérapeutique approprié visant à normaliser la pression artérielle, gage d'un risque cardio-vasculaire atténué. Une prise en charge globale des facteurs de risque cardio-vasculaire trouve ici une pleine implication. [less ▲]

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See detailQuantitative ultrasound techniques for the assessment of osteoporosis : Expert agreement on current status
Glüer, CC; Reginster, Jean-Yves ULg

in Journal of Bone and Mineral Research (1997), 12(8), 1280-1288

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See detailPhylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae.
Elmoualij, Benaïssa ULg; Duyckaerts, Claire ULg; Brasseur, Josette ULg et al

in Yeast (Chichester, England) (1997), 13(6), 573-581

The screening of the open reading frames identified in the whole yeast genome has allowed us to discover 34 proteins belonging to the mitochondrial carrier family. By phylogenetic study, they can be ... [more ▼]

The screening of the open reading frames identified in the whole yeast genome has allowed us to discover 34 proteins belonging to the mitochondrial carrier family. By phylogenetic study, they can be divided into 27 subfamilies including ADP/ATP, phosphate and citrate carriers, putative oxoglutarate and GDC carriers and 22 new subfamilies. Topology predictions using the 'positive inside rule' approach have shown that the yeast carriers are similarly oriented with both extremities exposed to the cytosol. In each subfamily, a strict conservation of the charged residues in the six transmembrane alpha-helices is observed, suggesting a functional role for these residues and the existence of 27 functionally distinct carriers. [less ▲]

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See detailA primal-dual approach in truss topology optimization
Beekers, M.; Fleury, Claude ULg

in Computers & Structures (1997), 64(1-4), 77-88

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are ... [more ▼]

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are bounds on bar volumes and the satisfaction of equilibrium equations. For a single load case and without bounds on bar volumes, the problem can be written as a linear programming problem with nodal displacements as variables. The addition to the objective function of a quadratic term vanishing at the optimum allows us to use a dual solution scheme. A conjugate gradient method is well suited to maximize the dual function. Several ground structures are introduced. For large networks, those where each node is connected to those situated in a certain vicinity give a good compromise between generating a reasonable number of bars and obtaining a sufficient number of possible directions. Some examples taken from the literature are treated to illustrate the quality of the solution and the influence of initial topology. (C) 1997 Civil-Comp Ltd and Elsevier Science Ltd. [less ▲]

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See detailL'AMDP appliqué à des réfugiés de Croatie
Mormont, Christian ULg

in Acta Psychiatrica Belgica (1997), 97(1), 55-60

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See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailPrognostic factors in urothelial renal pelvis and ureter tumors: A multicenter Rare Cancer Network study
Ozsahin, Mahmut; Zouhair, Abderrahim; Villà, S. et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 3(2(supp)), 290

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See detailDrug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments.
Scheen, André ULg

in Drugs (1997), 54(3), 355-68

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various ... [more ▼]

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various pharmacological approaches to improving glucose homeostasis, but those currently used in clinical practice either do not succeed in restoring normoglycaemia in most patients or fail after a variable period of time. For glycaemic regulation, 4 classes of drugs are currently available: sulphonylureas, biguanides (metformin), alpha-glucosidase inhibitors (acarbose) and insulin, each of which has a different mode and site of action. These standard pharmacological treatments may be used individually for certain types of patients, or may be combined in a stepwise fashion to provide more ideal glycaemic control for most patients. Adjunct treatments comprise a few pharmacological approaches which may help to improve glycaemic control by correcting some abnormalities frequently associated with NIDDM, such as obesity (serotoninergic anorectic agents) and hyperlipidaemia (benfluorex). There is intensive pharmaceutical research to find new drugs able to stimulate insulin secretion (new sulphonylurea or nonsulphonylurea derivatives, glucagon-like peptide-1), improve insulin action (thiazolidinediones, lipid interfering agents, glucagon antagonists, vanadium compounds) or reduce carbohydrate absorption (miglitol, amylin analogues, glucagon-like peptide-1). Further studies should demonstrate the superiority of these new compounds over the standard antidiabetic agents as well as their optimal mode of administration, alone or in combination with currently available drugs. [less ▲]

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See detailFloctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs
Lequesne, M; Fannius, J; Reginster, Jean-Yves ULg et al

in Revue du Rhumatisme (English ed.) (1997), 64(5), 327-333

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See detailPropriétés des profils de flux d'induction magnétique dans les céramiques supraconductrices
Vanderbemden, Philippe ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1997), 2

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See detailRoles of circadian rhythmicity and sleep in human glucose regulation.
Van Cauter, E.; Polonsky, K. S.; Scheen, André ULg

in Endocrine Reviews (1997), 18(5), 716-38

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See detail1897-1997 Les cent ans de la section des Eaux et Forêts
Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(4), 236-238

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See detailMultiple seawater-derived geochemical signatures in Indian oceanic pelagic clays
Fagel, Nathalie ULg; André, Luc; Debrabant, Pierre

in Geochimica et Cosmochimica Acta (1997), 61(5), 989-1008

This paper reports a geochemical study of oceanic clays. Major and trace elements were analyzed on smectite-rich, clay size (<2 mu m) samples, bulk sediments, and leachate residues from the Central Indian ... [more ▼]

This paper reports a geochemical study of oceanic clays. Major and trace elements were analyzed on smectite-rich, clay size (<2 mu m) samples, bulk sediments, and leachate residues from the Central Indian Basin. Sr-Nd isotopes were also studied to investigate their geochemical evolution during transport in the water column, sedimentation, and diagenesis. The region is of special interest because the sedimentation records the interaction between the detrital supply from the Bengal Fan in the north and the biosiliceous input associated with the equatorial divergence in the south. The clay size fractions display extremely variable trace element contents, e.g., [Ba] = 100-5000 ppm, [Sr] = 20-200 ppm, Ce/Ce* = 0.9-3.3, [Nd] = 10-50 ppm. Although in the argillaceous samples, clay size fractions have a similar trace element imprint to the bulk sediment, some major fractionations occur in the biosiliceous samples between the clay and the bulk sediment, especially for Sr and rare earth elements (REE). Three major components may account for the variable geochemical signatures of these pelagic clays. The first component (component A), already identified by Fagel et al. (1994), is characterized by a homogeneous geochemical signature (La-N/Yb-N = 1.03-1.05; Th/Ta = 12.8-21.1; Ba/Th similar to 28) and a nonradiogenic Nd isotopic composition (Nd-143/Nd-144 similar to 0.511880): it traces a detrital Himalayan-derived origin. The two other components display a seawater-derived isotopic composition with global Sr (Sr-87/Sr-86 similar to 0.709060) and regional Indian Ocean Nd(Nd-143/Nd-144 similar to 0.512200) signatures. Both components are enriched in Sr and Ba (Sr similar to 150 ppm, Ba/Th similar to 500), and they are either enriched in light rare earth elements (LREE, e.g., Nd similar to 50 ppm) in the argillaceous sediments (component B) or LREE-depleted (Nd < 20 ppm) in the biosiliceous sediments (component C). The frequent occurrence of micrometric (<5 mu m) Sr-REE-Th enriched barite grains showing three major habits (rhombic, rounded, dendritic) suggests that these biologically-derived mineral phases had a major role in the genesis of components B and C. A strong clay-barite equilibration is deduced from the Post Archean Australian Shales PAAS-like REE patterns of these barites and the Ba enrichment of the clays. We suggest that it results from two successive mechanisms of exchange. First, at the top of the oxygen minimum zone, the microbial-induced decay of organic matter is proposed to trigger a series of trace element transfers between the various particulate-forming components (clays, barites, and decaying organic coatings). This is proposed as the origin of the clay component B: the barite-derived components (Ba, Sr) and the organic-derived positive Ce anomaly are imported to the clay particles while the PAAS signature of the clays is retained by the remaining barite crystals. Second, after settling, the barites are believed to partly dissolve and recrystallize, especially in the anoxic part of the sedimentary column. This diagenetic barite dissolution is proposed as the origin of the clay component C. Copyright (C) 1997 Elsevier Science Ltd. [less ▲]

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See detailPEGASE, une méthodologie et un outil de simulation prévisionnelle pour la gestion de la qualité des eaux de surface
Smitz, Joseph ULg; Everbecq, Etienne ULg; Deliège, Jean-François ULg et al

in Tribune de l'Eau (La) (1997), 50/4(588), 73-82

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle ... [more ▼]

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle la qualité des eaux des rivières en fonction des rejets et apports de pollution. PEGASE est un outil opérationnel permettant d’orienter les choix des opérateurs publics et privés en matière de gestion des eaux de surface à l’échelle des bassins versants [less ▲]

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See detailCompte rendu de Moines et religieux au Moyen Age, éd. BERLIOZ (J.), Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailHydrostatic flattening, core structure, and translational mode of the inner core
Denis, Carlo; Rogister, Yves; Amalvict, Martine et al

in Physics of the Earth & Planetary Interiors (1997), 99(3-4), 195-206

Modern Earth models are constrained by an inertia coefficient y*=J(2)/H approximate to 0.3308 which leads to a so-called 'hydrostatic' flattening f(hyd) approximate to 1/299.9. The latter is in rather ... [more ▼]

Modern Earth models are constrained by an inertia coefficient y*=J(2)/H approximate to 0.3308 which leads to a so-called 'hydrostatic' flattening f(hyd) approximate to 1/299.9. The latter is in rather large disagreement with the observed flattening f approximate to 1/298.3. We show that a more satisfactory value of the inertia coefficient for constraining a standard Earth model is y approximate to 0.332, consistent with a hydrostatic flattening of about 1/298.6. The change of the value of the inertia coefficient from about 0.331 to about 0.332 significantly alters the density structure of the core, notably the density jump at the inner core boundary. It brings, as a by-produce, the hydrostatic values of J(2) and H to better agreement with the observed values than is presently thought, and most probably leads for the Slichter mode to a period of much longer than 5.42 h, which is the value computed for PREM. [less ▲]

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See detailOptimizing the treatment of Paget’s disease of bone
Reginster, Jean-Yves ULg; Gennari, C; Hosking, DJ et al

in Revue du Rhumatisme (English ed.) (1997), 64(4), 207-209

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See detailDesign for an Ipriflavone Multicenter European Fracture Study
Reginster, Jean-Yves ULg; Bufalino, L.; Christiansen, C. et al

in Calcified Tissue International (1997), 61(Suppl 1), 28-32

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large ... [more ▼]

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large multicentric European study was designed and is presently ongoing. Included in the study were 460 Caucasian, nonobese postmenopausal women aged > 45 and < 75 years, menopaused for at least 12 months. Inclusion was on the basis of a lumbar bone mineral density (BMD) lower than 2 SD compared with healthy women aged 50 years, corresponding to values below 0.860 g/cm2 (antero-posterior measurement) by Hologic QDR 1000. Women with prevalent vertebral fractures were excluded as well as those presenting secondary osteoporosis or having been treated with medications that could affect bone metabolism. This study was designed as a 3-year, double-blind, placebo-controlled, parallel group study that randomized the women to the oral administration of either 3 x 200 mg/day of i.p. or placebo. All patients received a daily supplement of 500 mg calcium. The primary purpose of the study was to evaluate the efficacy of i.p. in preventing vertebral nontraumatic fractures. Fracture is defined here as a > or = 20% decrease in any anterior, central, or posterior T4-L4 vertebral height. Blinded vertebral X-ray readings and vertebral morphometry have been centralized in an independent Center, with standardized evaluation of two experts. Power calculations have been based on the hypothesis that 21% of placebo-treated patients would fracture within 3 years and that treatment with i.p. would lead to a 50% reduction in the incidence of fracture. Statistical tests have been designed to have a power of 80%, with a type I error equal to 5%. Secondary endpoints were changes in vertebral, radial, and femoral BMD. Centralized controls on 100% BMD scans would ensure the good quality of BMD readings. This study should verify the hypothesis that i.p. significantly decreases the risk of vertebral fracture in postmenopausal, osteoporotic women. [less ▲]

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See detailCompte rendu de VAUCHEZ (A.), La spiritualité du Moyen Age occidental VIIIe-XIIIe siècle, Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailCharacterization of CuInTe2 thin films prepared by flash evaporation
Boustani, M.; El Assali, K.; Bekkay, T. et al

in Semiconductor Science & Technology (1997), 12

Thin films of CuInTe2 were grown by flash evaporation. The influence of the substrate temperature Ts during film deposition on the properties of the thin films was examined. CuInTe2 films were ... [more ▼]

Thin films of CuInTe2 were grown by flash evaporation. The influence of the substrate temperature Ts during film deposition on the properties of the thin films was examined. CuInTe2 films were structurally characterized by the grazing incidence x-ray diffraction (GIXD) technique. Investigation by this technique demonstrates that the surface of thin films of CuInTe2 prepared by flash vaporation at Ts > 100 °C exhibits the chalcopyrite structure with additional binary compounds in the surface. However, in the volume the films exhibit the chalcopyrite structure only; no foreign phases were observed. X-ray reflectometry was utilized to evaluate the critical reflection angle bc of CuInTe2 (bCuInTe2 c 0.32°) which permitted us to calculate the density of the films to be 6 g cm−3. The evaporated films were p type and the films deposited at Ts = 100 °C had a resistivity in the range 0.3–2 cm. From optical measurements we have determined the optical energy gap Eg 0.94 eV and the effective reduced mass m*r 0.07me . [less ▲]

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See detailVision artificielle et quantification de la forme de pommes
Leemans, Vincent ULg; Magein, Hugo ULg; Destain, Marie-France ULg

in Cahiers Agricultures (1997), 6

Golden delicious apples were characterised automatically by machine vision, taking into account six view of the cheeks and one of the stem end. The Fourier transform of the fruit boundaries were computed ... [more ▼]

Golden delicious apples were characterised automatically by machine vision, taking into account six view of the cheeks and one of the stem end. The Fourier transform of the fruit boundaries were computed and normalised. All the relevant information about the shape was included in the first fifteen harmonics. Moreover, particular harmonics were found to characterise the shape of the Golden delicious variety. By using the amplitude of particular harmonics in a discriminant analysis, apple were sorted into categories defined by EU, with a precision around 96%. The proposed method may also be used to compare varieties objectively, in order to identify relation between physiology and shape. [less ▲]

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See detailInfluence of Diazepam on Contingent Negative Variation
Papart, Patrick ULg; Ansseau, Marc ULg; Timsit-Berthier, M.

in Human Psychopharmacology (1997), 12

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See detailIn vivo behavior of poly(D,L)-lactide microspheres designed for chemoembolization
Flandroy, P.; Grandfils, Christian ULg; Danen, B. et al

in Journal of Controlled Release (1997), 44(2-3), 153-170

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is ... [more ▼]

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is limited by the lack of appropriate and reliable embolization materials. Recently, calibrated microspheres of poly(D,L)-lactide have proved to be promising in embolization. Nevertheless, repetitive chemoembolization requires the availability of microspheres degradable within a few days. For this purpose, microspheres consisting of a blend of two polyesters of a very different molecular weight (Mn =65 000 and 3500 in a 16:84 wt. ratio) have been prepared and injected in the renal arteries of rabbits. The in vivo fate of these two component microspheres has been compared by radiology and histology to microspheres prepared from the high molecular weight poly(D,L)-lactide. Furthermore, the in vivo degradation of the polymer has been measured by size exclusion chromatography after quantitative reextraction from the embolized kidney. Degradation kinetics has been compared to data previously reported in vitro. According to the observations performed during the in vivo study, the 50/50 microspheres appear more useful for the chemoembolization of tumors. [less ▲]

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See detailThe effects of shunting sytemic venous blood into the portal circulation. Review, experiences and future perspectives
D'Silva, Milbhor; Wolf, P.; Bonnet, Pierre ULg

in Archives of Hellenic Medecine (1997), 14(3), 246-264

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See detailSpecific repertoire of olfactory receptor genes in the male germ cells of several mammalian species
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Genomics (1997), 39

Olfactory receptors constitute the largest family among G protein-coupled receptors, with up to 1000 members expected. We have previously shown that genes belonging to this family were expressed in the ... [more ▼]

Olfactory receptors constitute the largest family among G protein-coupled receptors, with up to 1000 members expected. We have previously shown that genes belonging to this family were expressed in the male germ line from both dog and human. We have subsequently demonstrated the presence of one of the corresponding olfactory receptor proteins during dog spermatogenesis and in mature sperm cells. In this study, we investigated whether the unexpected pattern of expression of olfactory receptors in the male germ line was conserved in other mammalian species. Using reverse transcription-PCR with primers specific for the olfactory receptor gene family, about 20 olfactory receptor cDNA fragments were cloned from the testis of each mammalian species tested. As a whole, they displayed no sequence specificity compared to other olfactory receptors, but highly homologous, possibly orthologous, genes were amplified from different species. Finally, their pattern of expression, as determined by RNase protection assay, revealed that many but not all of these receptors were expressed predominantly in testis. The male germ line from each mammalian species tested ins thus characterized by a specific repertoire of olfactory receptors, which display a pattern of expression suggestive of their potential implication in the control of sperm maturation, migration, or fertilization [less ▲]

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See detailDynamique de défense du nid chez Symphodus ocellatus (Forsskål, 1775), poisson labridé méditerranéen. I. Comportements agonistiques entre le mâle territorial nidificateur et cinq autres espèces de labridés
Ylieff, Marc ULg; Michel, Christian ULg; Voss, Jacques

in Cahiers d'Ethologie (1997), 17(1), 49-74

This research in the field consists of a study of interspecific agonistic behaviour of territorial male in Symphodus ocellatus. This behaviour is useful for brood and nest defense. Four questions ... [more ▼]

This research in the field consists of a study of interspecific agonistic behaviour of territorial male in Symphodus ocellatus. This behaviour is useful for brood and nest defense. Four questions involving Symphodus ocellatus towards S. tinca, S. mediterraneus, S. roissali, Thalassoma pavo et Coris julis were investigated. The questions of interest were: (1) aggressors or intruders motivations (predation of the brood (a) and/or territorial conflicts (b)), (2) the recognition of this or that species (recognition studied with selective attacks by territorial male), (3) the organ(s) of perception used for this recognition and (4) the importance of territorial male investment in nest defense; this role could ensure a successful reproduction of the species. Our observations and experimentations (tested labrid fishes presented to T. males) allow us to affirm that in S. ocellatus, nesting territorial males recognize the various tested labrid fishes; that the organ of perception used for social recognition is the visual channel; that spawn protection insured by territorial male, a task guided by his visual system, is necessary towards menace of his congeners, but also the other fishes living in his habitat. Nevertheless, if it’s becoming clear that the Mediterranean labrid fishes have the ability to recognize and preferentially interact with particular individuals, the answer of the question 1, concerning aggressors motivations, is not yet clearly known. [less ▲]

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See detailUne chambre noire pour l’analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1997), 33

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See detailWhole organ vascularized cluster heart-thymus allografting : Experiences with a novel experimental model
D'Silva, Milbhor; Antoniou, E.; Howie, A. J. et al

in Cardiovascular Engineering : An International Journal (1997), 2(1), 65-74

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See detailEvolution du couvert vegetal dans la region de Kinshasa (1960-1987) selon une approche cartographique.
Tshibangu, K. W. T.; Engels, Patrick ULg; Malaisse, François ULg

in Geo-Eco-Trop (1997), 21(1-4),

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See detailCalibration of a finite element model for bolted endplate steel connections
Bursi, O.; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (1997), 44(No 3), 225-262

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See detailActivation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells
Legrand-Poels, Sylvie ULg; Maniglia, Salvator; Boelaert, J. R. et al

in Biochemical Pharmacology (1997)

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See detailThe Color Purple - les Blues Pourpres d'Alice Walker
Sacré, Robert ULg

in Les Cahiers du Jazz (1997), 12

Un livre (1982) - un film ( Steven Spielberg, 1985)

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See detailQuelques arthropodes de nos maisons
Loneux, Michèle ULg

in Cahiers d'Ethologie (1997), 17(1), 75-124

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See detailLe comportement de reproduction du goujon, Gobio gobio, en aquarium
Poncin, Pascal ULg; Jeandarme, J.; Rinchard, J. et al

in Bull. Fr. Pêche Piscic. (1997)

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See detailWhat Is the Risk of Transferral of an Undetected Neoplasm During Organ Transplantation?
Detry, Olivier ULg; Bonnet, Pierre ULg; Honore, Pierre ULg et al

in Transplantation Proceedings (1997), 29(5), 2410-1

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See detailUretero-arterial fistula: two observations.
VAN DAMME, Hendrik ULg; KEPPENNE, Véronique ULg; SakalihasanN, Natzi ULg et al

in Acta Chirurgica Belgica (1997), 97(3), 133-6

Two cases of life-threatening haematuria, secondary to an uretero-arterial fistula, are reported. Both cases present predisposing causative factors. One patient had a combination of previous aorto ... [more ▼]

Two cases of life-threatening haematuria, secondary to an uretero-arterial fistula, are reported. Both cases present predisposing causative factors. One patient had a combination of previous aorto-bifemoral bypass grafting, an iliac artery aneurysm (retrogradely perfused), and an indwelling ureteral stent for ureteral compression. The other patient had previous aortoiliac surgery and obstructive uropathy with chronic urinary tract infection. Preoperative diagnosis of uretero-arterial fistula was made in only one patient. He was successfully operated (exclusion of the iliac aneurysm). In the other patient, nephrectomy was attempted to control reno-ureteral bleeding of unknown origin. Fatal recidive of brisk haematuria occurred some days later. Factors contributing to the development of uretero-arterial fistula, their diagnosis and optimal treatment are discussed. [less ▲]

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See detailThe Cloning And Sequencing Of An Ovine C-Myc Cdna
Kiermer, V.; Dequiedt, Franck ULg; Masengo, R. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1997), 7(3-4),

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See detailMetacognitive Realism: A cognitive Style or a Learning Strategy?
Jans, Véronique; Leclercq, Dieudonné ULg

in British Journal of Educational Technology (1997), 17(1-2),

Identifies metacognitive realism as the accurate assessment by a learner of their knowledge on a subject. Considers whether realism in metacognition is a stable trait, and possible influences. Briefly ... [more ▼]

Identifies metacognitive realism as the accurate assessment by a learner of their knowledge on a subject. Considers whether realism in metacognition is a stable trait, and possible influences. Briefly reviews the literature and experimental evidence and concludes that metacognitive realism is both style and strategy. [less ▲]

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See detailEvaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways
Duvivier, Dominique Hannia; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Veterinary Research (1997), 28(6), 557-564

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M ... [more ▼]

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M). The in vitro inhalation study was performed using the cascade impaction method (Andersen Sampler) adapted to imitate nasal breathing. The amount of ipratropium found in the device, the artificial upper airways and the six stages of the Andersen Sampler was measured using high precision liquid chromatography. Stage 1 of the Andersen Sampler was considered to be the respirable fraction and stages 2 to 6 to be the non-respirable fraction. It was concluded that the theoretical respirable fraction of ipratropium obtained after DPI through Inhalator M was influenced by relative air humidity, air flow and the position of the device, whereas the number of successive inspirations and the duration of inspiration did not affect this fraction of the drug. [less ▲]

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See detailPositron emission tomography in parkinsonism
Salmon, Eric ULg

in Acta Neurologica Belgica (1997), 97(3), 187-191

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See detailImage du mois. Syncope vasovagale en direct.
Scheen, André ULg; Marchand, Monique ULg; Juchmes, J.

in Revue Médicale de Liège (1997), 52(5), 315

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See detailInfestation par Paramphistomum sp. chez le bovin : description d'un premier cas en Belgique
Losson, Bertrand ULg; Cassart, Dominique ULg; Mignon, Bernard ULg

in Annales de Médecine Vétérinaire (1997), 142

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See detailFunctional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle.
GOTHOT, André ULg; Pyatt, R.; McMahel, J. et al

in Blood (1997), 90(11), 4384-93

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the ... [more ▼]

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the cell cycle by flow cytometric cell sorting. In both bone marrow (BM) and mobilized peripheral blood (MPB) CD34(+) cells, primitive long-term hematopoietic culture-initiating cell (LTHC-IC) activity was higher in CD34(+) cells isolated in G0 (G0CD34(+) cells) than in those residing in G1 (G1CD34(+) cells). However, as MPB CD34(+) cells displayed a more homogeneous cell-cycle status within the G0 /G1 phase and a relative absence of cells in late G1 , DNA/RNA fractionation was less effective in segregating LTHC-IC in MPB than in BM. BM CD34(+) cells belonging to four subcompartments of increasing RNA content within the G0 /G1 phase were evaluated in functional assays. The persistence of CD34 expression in suspension culture was inversely correlated with the initial RNA content of test cells. Multipotential progenitors were present in G0 or early G1 subcompartments, while lineage-restricted granulomonocytic progenitors were more abundant in late G1 . In vitro hematopoiesis was maintained for up to 6 weeks with G0CD34(+) cells, whereas production of clonogenic progenitors was more limited in cultures initiated with G1CD34(+) cells. To test the hypothesis that primitive LTHC-ICs would reenter a state of relative quiescence after in vitro division, BM CD34(+) cells proliferating in ex vivo cultures were identified from their quiescent counterparts by a relative loss of membrane intercalating dye PKH2, and were further fractionated with Hst and PY. The same functional hierarchy was documented within the PKH2(dim) population whereby LTHC-IC frequency was higher for CD34(+) cells reselected in G0 after in vitro division than for CD34(+) cells reisolated in G1 or in S/G2 + M. However, the highest LTHC-IC frequency was found in quiescent PKH2(bright) CD34(+) cells. Together, these results support the concept that cells with distinct hematopoietic capabilities follow different pathways during the G0 /G1 phase of the cell cycle both in vivo and during ex vivo culture. [less ▲]

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See detailA 2-year phase II study with 1-year of follow-up of risedronate (NE58095) in postmenopausal osteoporosis
Clemmesen, B; Ravn, P; Zegels, Brigitte ULg et al

in Osteoporosis International (1997), 7

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See detailLe maintien des droits aux prestations de santé lors d'une séparation de fait ou de corps
Michiels, Olivier ULg

in Divorce : Actualité Juridique, Sociale et Fiscale (1997)

L'article examine la question du maintien des droits aux prestations de santé lors d'une séparation de corps ou d'une séparation de fait.

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See detailPreuve et conséquences de la séparation de fait en matière d’assujettissement et d’établissement de l’impôt des personnes physiques
Orban, Lionel ULg

in Commission Université-Palais – Formation permanente – Droit fiscal. Volume XIV – Février 1997 (1997)

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See detailA domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.
Jousset, C.; Carron, C.; Boureux, A. et al

in EMBO Journal (1997)

TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino ... [more ▼]

TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino-terminal domain conserved in a subset of the ETS proteins has evolved to generate a specialized protein-protein interaction interface which is likely to be an important determinant of their specificity as transcriptional regulators. [less ▲]

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See detail5-(Diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide : Synthesis and Evaluation of Spin Trapping Properties
Roubaud, Valérie; Mercier, Anne; Olive, Gilles ULg et al

in Journal of the Chemical Society. Perkin Transactions 2 (1997), 9

A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been ... [more ▼]

A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been investigated and the hydroxyl and superoxide spin adducts characterised. The persistence of the superoxide spin adduct obtained with 3 is compared with those of the analogues obtained with DEPMPO [5-(diethoxyphosphoryl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide] and DMPO in both phosphate buffer and pyridine. In 0.1 M phosphate buffer at pH 7.0, the HOO-3? adduct is found to be 2.8 times more persistent than HOO-DMPO?, but 5.7 times less than HOO-DEPMPO?. In phosphate buffer, HOO-3? decomposes to give HO-3?. The stereoselectivity of the addition of free radicals on 3 is generally poor, and mixtures of diastereomers have been observed by EPR. The overall spin trapping behaviour of nitrone 3 is more similar to that of DMPO than that of DEPMPO. [less ▲]

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See detailLa maladie de Buerger: aspects cliniques et pronostiques
VAN DAMME, Hendrik ULg; Deprez, E.; DEFRAIGNE, Jean ULg et al

in Revue Médicale de Liège (1997), 52(10), 675-82

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See detailNew insights into the metastasis-associated 67 kD laminin receptor.
Menard, S.; Castronovo, Vincenzo ULg; Tagliabue, E. et al

in Journal of Cellular Biochemistry (1997), 67(2), 155-65

The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated ... [more ▼]

The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated by different cell surface molecules, including the monomeric 67 kD laminin receptor. This molecule appears to be very peculiar since so, far only a full-length gene encoding a 37 kD precursor protein has been isolated and the mechanism by which the precursor reaches the mature form is not understood. Based on clinical data, which clearly demonstrate the importance of the receptor in tumor progression, studies were conducted to define the structure, expression, and function of this laminin receptor as a step toward developing therapeutic strategies that target this molecule. The data suggest that acylation of the precursor is the key mechanism in maturation of the 67 kD form. The function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin-accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Downregulation of the receptor expression on tumor cells might open new therapeutic approaches to decrease tumor aggressiveness. [less ▲]

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See detailSIME: A hybrid approach to fast transient stability assessment and contingency selection
Zhang, Ywee; Wehenkel, Louis ULg; Rousseaux, Patricia ULg et al

in International Journal of Electrical Power & Energy Systems (1997), 19(3), 195-208

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME ... [more ▼]

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME for Single Machine Equivalent. SIME relies on a particular direct method coupled with time-domain programs so as to combine the strengths of both, namely: the flexibility with respect to power system modelling of time-domain methods; the speed and richer information of the direct method. This paper lays the foundations of SIME, devises appropriate techniques for transient stability assessment per se and for contingency screening, and finally integrates these two techniques in a fully general function, i.e. able to comply with any power system modelling and stability scenario, and to assess any type of stability limits (critical clearing times or power limits). Throughout, real-world examples illustrate the proposed techniques and highlight their performances. [less ▲]

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See detailSpecific Modulation Of The Fusogenic Properties Of The Alzheimer Beta-Amyloid Peptide By Apolipoprotein E Isoforms
Pillot, T.; Goethals, M.; Vanloo, B. et al

in European Journal of Biochemistry (1997), 243(3), 650-9

C-terminal fragments of the Alzheimer amyloid peptide (amino acids 29-40 and 29-42) have physico-chemical properties related to those of the fusion peptides of viral proteins and they are able to induce ... [more ▼]

C-terminal fragments of the Alzheimer amyloid peptide (amino acids 29-40 and 29-42) have physico-chemical properties related to those of the fusion peptides of viral proteins and they are able to induce the fusion of liposomes in vitro. We proposed that these properties could mediate a direct interaction of the amyloid peptide with cell membranes and account for part of the cytotoxicity of the amyloid peptide. In view of the epidemiologic and biochemical linkages between the pathology of Alzheimer's disease and apolipoprotein E (apoE) polymorphism, we examined the potential interaction between the three common apoE isoforms and the C-terminal fragments of the amyloid peptide. We show that, at low concentration, only apoE2 and apoE3 are potent inhibitors of the amyloid peptide fusogenic and aggregational properties, whereas the apoE4 isoform has no effect. We further show that the protective effect of apoE is mediated by the formation of stable apoE/amyloid peptide complexes, as determined by tryptophan emission fluorescence measurements and by gel electrophoresis. The interaction specificity between apoE2 and apoE3 and the amyloid fragments is demonstrated here, since other apolipoproteins (e.g. apolipoprotein A-I and A-II), with similar amphipathic structures, do not interact with the amyloid C-terminal fragments. Finally, we show that, reciprocally, the amyloid peptide can interact directly with the apoE2 and apoE3 isoforms to decrease or perturb their normal association with lipids. These data suggest that the 29-40 and 29-42 domains of the amyloid peptide could be critical for the amyloid-apoE interaction, and that apoE2 and apoE3 isoforms, but not apoE4, could play a protective role against the formation of amyloid aggregates and/or against their interaction with cellular membranes. [less ▲]

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See detailGREES recommendations for the Registration of new drugs in the prevention and treatment of osteoporosis
Reginster, Jean-Yves ULg; Compston, J

in Calcified Tissue International (1997), 60

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See detailAn Easy Way to Increase the Finite-Sample Efficiency of the Resampled Minimum Volume Ellipsoid Estimator
Croux, Christophe ULg; Haesbroeck, Gentiane ULg

in Computational Statistics & Data Analysis (1997), 25

In a robust analysis, the minimum volume ellipsoid (MVE) estimator is very often used to estimate both multivariate location and scatter. The MVE estimator for the scatter matrix is defined as the ... [more ▼]

In a robust analysis, the minimum volume ellipsoid (MVE) estimator is very often used to estimate both multivariate location and scatter. The MVE estimator for the scatter matrix is defined as the smallest ellipsoid covering half of the observations, while the MVE location estimator is the midpoint of that ellipsoid. The MVE estimators can be computed by minimizing a certain criterion over a high-dimensional space. In practice, one mostly uses algorithms based on minimization of the objective function over a sequence of trial estimates. One of these estimators uses a resampling scheme, and yields the (p + 1)-subset estimator. In this note, we show how this estimator can easily be adapted, yielding a considerable increase of statistical efficiency at finite samples. This gain in precision is also observed when sampling from contaminated distributions, and it becomes larger when the dimension increases. Therefore, we do not need more computation time nor do we lose robustness properties. Moreover, only a few lines have to be added to existing computer programs. The key idea is to average over several trials close to the optimum, instead of just picking out the trial with the lowest value for the objective function. The resulting estimator keeps the equivariance and robustness properties of the original MVE estimator. This idea can also be applied to several other robust estimators, including least-trimmed-squares regression. [less ▲]

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See detailCompte rendu de Sénèque et la prose latine, (Entretiens sur l'Antiquité classique, 26), Fondation Hardt, 1991, 400 pp.
Longrée, Dominique ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1997)

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See detailImprovement of inland navigation in developping countries: the training center of Palembang (Sumatra, Indonesia), an example of transfer of technology through education
Marchal, Jean ULg

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (1997), Nouvelle Série 42(4)(1er trimestre), 10

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See detailClinical characteristics, prognosis and treatment for pelvic cryptorchid seminoma
Li; COUCKE, Philippe ULg; Qian et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 38(2), 351-357

Purpose: To analyze the clinical characteristics, prognosis, and treatment outcome of pelvic cryptorchid seminoma (PCS), and to determine whether whole abdominal-pelvic irradiation for Stage I disease is ... [more ▼]

Purpose: To analyze the clinical characteristics, prognosis, and treatment outcome of pelvic cryptorchid seminoma (PCS), and to determine whether whole abdominal-pelvic irradiation for Stage I disease is necessary. Methods and Materials: From 1958 to 1991,60 patients with PCS were treated at the Cancer Hospital of Chinese Academy of Medical Sciences, Beijing. They presented with a lower abdominal mass and showed a predominance for the right side. A high proportion of patients with PCS [ 26 of 60 (43% )] had metastatic disease, compared to 20% of those with scrotal seminoma, and there was a tendency toward a higher frequency of pelvic nodal metastases. There were 34 Stage I, 6 Stage IIA, 11 Stage IIB, 5 Stage III, and 4 Stage IV patients. Of these 60 patients, 56 underwent laparotomy with or without cryptorchiectomy (37 radical orchiectomy, 7 partial orchiectomy, and 12 biopsy of the primary or cervical node), and 4 cervical node biopsy only. All patients were further treated with radiotherapy, chemotherapy, or a combination of both. Patients with Stage I and II disease received radiotherapy, whereas patients with Stage III and IV were treated with chemotherapy. Results: The overall and disease-free survivals at 5 and 10 years were 92% and 87%, and 88% and 84%, respectively. The 5- and lo-year survivals were 100% for Stage I, 94% and 87% for Stage II, and 56% and 42% for Stage III/IV, respectively @ < 0.05). Volume of irradiation, i.e., whole abdominal-pelvic radiotherapy ( 10 patients), versus hockey-stick encompassing paraaortic, ipsilateral iliac nodes and the primary tumor or tumor bed (17) did not influence outcome in Stage I patients. Five patients relapsed within 2-12 years after treatment, and four of these patients were successfully salvaged. Four patients developed a second malignant tumor and died. Conclusion: Stage I and II PCS can he adequately controlled by radiotherapy regardless of the surgical procedure. Whole abdominal-pelvic irradiation for Stage I and IIA disease is not required, and fields can be limited to the paraaortic, ipsilateral iliac nodes and primary tumor or tumor bed. We recommend platinum-based chemotherapy for Stage IIB-IV PCS. 0 1997 Elsevier Science Inc. [less ▲]

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See detailGezonheidszorg : actuele standpunten. Diagnostiek van osteoporose
Devogelaer, JP; Reginster, Jean-Yves ULg; Raeman, F et al

in Tijdschrift voor Geneeskunde (1997), 53(10), 639-645

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See detailTechniques et indications de la bronchoscopie interventionnelle.
CORHAY, Jean-Louis ULg; Bury, Thierry ULg; Radermecker, Marc ULg et al

in Revue Médicale de Liège (1997), 52(10), 657-65

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See detailEffect of bi-level positive airway pressure (BiPAP) nasal ventilation on the postoperative pulmonary restrictive syndrome in obese patients undergoing gastroplasty.
Joris, Jean ULg; Sottiaux, Thierry; Chiche, Jean-Daniel et al

in CHEST (1997), 111(3), 665-70

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines ... [more ▼]

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines pressure support ventilation and positive end-expiratory pressure via a nasal mask, could allow alveolar recruitment during inspiration and prevent expiratory alveolar collapse, and therefore limit the postoperative pulmonary restrictive syndrome. This study investigated the effect of BiPAP on postoperative pulmonary function in obese patients after gastroplasty. DESIGN: Prospective controlled randomized study. SETTING: GI surgical ward in a university hospital. PATIENTS: Thirty-three morbidly obese patients scheduled for gastroplasty were studied. INTERVENTION: The patients were assigned to one of three techniques of ventilatory support during the first 24 h postoperatively: O2 via a face mask, BiPAP System 8/4, with inspiratory and expiratory positive airway pressure set at 8 and 4 cm H2O, respectively, or BiPAP System 12/4 set at 12 and 4 cm H2O. Pulmonary function (FVC, FEV1, and peak expiratory flow rate [PEFR]) were measured the day before surgery, 24 h after surgery, and on days 2 and 3. Oxygen saturation by pulse oximeter (SpO2) was also recorded during room air breathing. RESULTS: Three patients were excluded. After surgery, FVC, FEV1, PEFR, and SpO2 significantly decreased in the three groups. On day 1, FVC and FEV1 were significantly improved in the group BiPAP System 12/4, as compared with no BiPAP; SpO2 was also significantly improved. After removal of BiPAP System 12/4, these benefits were maintained, allowing faster recovery of pulmonary function. No significant effects were observed on PEFR. BiPAP System 8/4 had no significant effect on the postoperative pulmonary restrictive syndrome. CONCLUSION: Prophylactic use of BiPAP System 12/4 during the first 24 h postoperatively significantly reduces pulmonary dysfunction after gastroplasty in obese patients and accelerates reestablishment of preoperative pulmonary function. [less ▲]

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See detailProtection possessoire et convention. Quand l'usufruitier devient bailleur
Lecocq, Pascale ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailThe lowest 5g-6h supermultiplet of Fe II
Biémont, Emile ULg; Johansson, S.; Palmeri, P.

in Physica Scripta (1997), 55

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See detailEvolution des populations du tétras lyre Tetrao tetrix L. en Europe: un essai de synthèse
Loneux, Michèle ULg; Ruwet, Jean-Claude

in Cahiers d'Ethologie (1997), 17((2-3-4)), 287-343

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