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See detailEffect of residence time on the efficacy of antidandruff shampoos.
Pierard, Claudine ULiege; Uhoda, Emmanuelle ULiege; Loussouarn, G. et al

in International Journal of Cosmetic Science (2003), 25(6), 267-71

Dandruff is known to be controlled by fungistatic shampoos active against Malassezia spp. These products also remove the loosely attached scales. This study was performed to assess the effect of a 5-min ... [more ▼]

Dandruff is known to be controlled by fungistatic shampoos active against Malassezia spp. These products also remove the loosely attached scales. This study was performed to assess the effect of a 5-min residence time on the efficacy of antidandruff shampoos. Two commercially available shampoos were used in two groups of 21 panelists with severe dandruff. They contained either 1% ketoconazole or 1% piroctone olamine. In each group, intraindividual comparisons were made by a split-scalp design between the effect of a 5-min residence time versus no residence time. Both shampoos induced significant reductions in scaliness and yeast colonization. The beneficial effects were obvious immediately after one single shampooing and 3 days later as well. The improvement was greater with a 5-min residence time. The piroctone olamine treatment benefited more than the ketoconazole treatment from the extension of shampoo-exposure time. In conclusion, the benefit of a residence time in treating dandruff is documented. The level of improvement in efficacy may vary according to the nature of the shampoo. [less ▲]

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See detailAbsolute and relative quantification : beyond mutually exclusive word classes.
Brems, Lieselotte ULiege; Davidse, Kristin

in Belgian Journal of English Language and Literatures. New Series (2003), 1

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See detailOne-pot surfactant assisted synthesis of aluminosilicate macrochannels with tunable micro- or mesoporous wall structure
Léonard, Alexandre ULiege; Blin, J.-L.; Su, B.-L.

in Chemical Communications (2003), 9(20), 2568-2569

A one-step surfactant assisted synthesis pathway was developed leading to novel hierarchical macro-meso- (or micro-)porous aluminosilicates made of an assembly of macrochannels with openings between 0.5 ... [more ▼]

A one-step surfactant assisted synthesis pathway was developed leading to novel hierarchical macro-meso- (or micro-)porous aluminosilicates made of an assembly of macrochannels with openings between 0.5 and 2.0 μm and wormhole-like amorphous walls with tunable pore sizes. [less ▲]

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See detailThe impact of reimbursement criteria on the appropriateness of 'statin' prescribing.
Autier, Philippe; Creplet, Jean; Vansant, Greet et al

in European Journal of Cardiovascular Prevention & Rehabilitation (2003), 10(6), 456-62

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated ... [more ▼]

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated the possible impact of these regulations on characteristics of Belgian patients receiving a lipid-lowering drug. DESIGN: From 1998 to 2000, standard questionnaires on coronary risk factors and treatments with lipid-lowering drugs were completed by 301 GPs sampled at random in the 11 Belgian Provinces. Questionnaires had to be completed for 18 consecutive patients 35 years old or more attending GPs' practices, irrespective of the underlying motive for attendance. RESULTS: Of the 5511 patients included in the study, 1519 (28%) had established coronary disease or diabetes mellitus, or > or = 2 non-cholesterol coronary risk factors. Most (70%) of these patients were not treated with a lipid-lowering drug. Only 22% of patients with established coronary disease, 10% of patients with diabetes mellitus and 9% of patients with > or = 2 coronary risk factors were treated with a statin. Fifty-nine percent of fibrate users and 50% of statin users had a pre-treatment cholesterol level above 250 mg/dl, but had no or only one non-cholesterol coronary risk factor. CONCLUSIONS: In Belgium, the majority of patients at higher risk of coronary event do not benefit from lipid-lowering drugs, particularly the statins. In contrast, one of two statin users and three of five fibrate users should probably not receive the drug prescribed. Regulation based on blood cholesterol level encourages the overlooking of other risk factors relevant for selecting patients having the greatest chance to benefit from statin treatment. [less ▲]

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See detailStratégies thérapeutiques dans les adénomes somatotropes avec extension extrasellaire. Place du traitement médical. Etude consensus du Répertoire français de l'Acromégalie.
Jaquet, Ph; Cortet-Rudelli, Ch; Sassolas, G. et al

in Annales d'Endocrinologie (2003), 64(6), 434-441

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by ... [more ▼]

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by stereotactic or conventional radiotherapy. In these patients (including 37 women), aged 21-77 yr. (45.7 +/- 13.3), GH concentrations ranged from 2-260 microg/L (38.6 +/- 44.3), and IGF I from 86-967% of age-matched upper limit of normal (303 +/- 164). Maximal diameter of the adenoma at MRI was 11-36.5 mm (20.4 +/- 6.5), with cavernous sinus involvement in 68% of cases. Three subgroups were defined: 20 patients treated by long-acting somatostatin analogs only (group M), for a mean duration of 3 yr. (extremes 1-7 yr.), 48 patients initially treated by transsphenoidal surgery (group C), of whom 21 were secondarily treated by long-acting somatostatin analogs (group CM) for a mean duration of 1.2 yr. (extremes 0.2-2 yr.). All 3 groups were not statistically different in terms of tumor mass and initial levels of GH and IGF-1. Patients from group M were significantly older than those of the other groups (p<0.05). RESULTS: 46% of patients from group C after surgery vs. 45% of patients from group M had a mean GH below 2.5 microg/L. Biochemical remission (GH<2.5 microg/L and normal IGF1 normal) was obtained in 31% of cases in group C, vs. 25% in group M. In this group, a decrease of the largest tumor diameter was observed in 10 patients (71.5%), ranging from 10-25% in 7 (50%) and exceeded 50% in 3 (21.5%). In group CM, the biochemical remission rate (42%) and final GH or IGF1 values were not significantly different from group M. In conclusion, these data suggest that surgery or long-acting somatostatin analogs have a comparable efficacy in terms of remission rates in somatotroph macroadenomas with extrasellar extensions. [less ▲]

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See detailEarly detection of relapse by whole-body positron emission tomography in the follow-up of patients with Hodgkin's disease.
Jerusalem, Guy ULiege; Beguin, Yves ULiege; Fassotte, Marie-France ULiege et al

in Annals of Oncology (2003), 14(1), 123-30

BACKGROUND: Relapse after treatment of Hodgkin's disease (HD) is usually identified as a result of the investigation of symptoms. We undertook this study to examine the value of whole-body positron ... [more ▼]

BACKGROUND: Relapse after treatment of Hodgkin's disease (HD) is usually identified as a result of the investigation of symptoms. We undertook this study to examine the value of whole-body positron emission tomography (PET) for the detection of preclinical relapse. PATIENTS AND METHODS: Thirty-six patients underwent 2-[fluorine-18]fluoro-2-deoxy-D-glucose ((18)F-FDG) PET at the end of treatment and than every 4-6 months for 2-3 years after the end of polychemotherapy and/or radiotherapy. In those cases of abnormal (18)F-FDG accumulation a confirmatory study was performed 4-6 weeks later. RESULTS: One patient had residual tumor and four patients relapsed during a follow-up of 5-24 months. All five events were correctly identified early by (18)F-FDG PET. Residual tumor or relapse was never first diagnosed based on clinical examination, laboratory findings or computed tomography (CT) studies. Two patients presented B symptoms and the three others were asymptomatic at the time of residual disease or relapse. Confirmation of residual disease or relapse was obtained by biopsy in four patients 1, 1, 5 and 9 months after PET and by unequivocal clinical symptoms and CT studies in one patient 3 months after PET. False-positive (18)F-FDG PET studies incorrectly suggested possible relapse in six other patients, but the confirmatory PET was always negative. Our study also provides important information about physiological (18)F-FDG uptake in the thymus. CONCLUSIONS: Our data suggest the potential of (18)F-FDG PET to detect preclinical relapse in patients with HD. This could help identify patients requiring salvage chemotherapy at the time of minimal disease rather than at the time of clinically overt relapse. Further studies are warranted to determine the impact of PET on treatment management and outcome. In fact, the aim of follow-up procedures is not only to detect preclinical relapse but mainly to obtain better results by starting salvage treatment earlier. A cost-benefit analysis will also be necessary before (18)F-FDG PET can be used routinely in the follow-up of patients with HD. [less ▲]

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See detailL'adiponectine: une nouvelle adipocytokine.
Lebas, Eglantine ULiege; Paquot, Nicolas ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2003), 58(9), 554-8

Adipose tissue is not simply a store of excess energy, but also secretes a variety of proteins into circulating blood that influence systemic metabolism. These include tumor necrosis factor (TNF-alpha ... [more ▼]

Adipose tissue is not simply a store of excess energy, but also secretes a variety of proteins into circulating blood that influence systemic metabolism. These include tumor necrosis factor (TNF-alpha), plasminogen activator inhibitor type 1 (PAI-1), leptin, resistine and adiponectin. These are collectively known as adipocytokines. Adiponectin (also referred to as AdipoQ, Acrp 30, apM1 or GBP28) is a novel adipose-specific protein. A recent genome study mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome on chromosome 3q27, where the adiponectin gene is located. Adiponectin is a peculiar adipocytokine because in contrast to the markedly increased levels of many others, as leptin or TNF-alpha, its level is reduced in obesity and type 2 diabetes. The administration of thiazolidinediones, which are synthetic PPARs-gamma ligands, significantly increases the plasma adiponectin concentrations, an effect that could improve insulin sensitivity. Thus, the administration of adiponectin may provide a novel treatment modality for insulin resistance and type 2 diabetes. [less ▲]

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See detailInstrumental investigations in primary headache. An updated review and new perspectives
Friberg, L.; Sandrini, G.; Janig, W. et al

in Functional Neurology (2003), 18(3, JUL-SEP), 127-144

While some instrumental techniques are clearly useful for differentiating symptomatic forms from primary headache, the usefulness of certain other techniques, neurophysiological investigations in ... [more ▼]

While some instrumental techniques are clearly useful for differentiating symptomatic forms from primary headache, the usefulness of certain other techniques, neurophysiological investigations in particular, in clinical practice is still debated. A Task Force of the European Federation of Neurological Societies has recently proposed guidelines and recommendations on the use of neurophysiological tests and neuroimaging procedures in non-acute headache. This article reviews many of the most important literature references relevant to this topic and looks at the prospects for future research. [less ▲]

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See detailL’expérience politique des jeunes, par Anne Muxel (compte rendu)
Fournier, Bernard ULiege

in Politique et Sociétés (2003), 22(2)

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See detailL'enseignement en Communauté française : un haut degré d'iniquité
Baye, Ariane ULiege; Nicaise, Julien; Straeten, Marie-Hélène et al

in Espace de Libertés : Magazine du Centre d'Action Laïque (2003), (316), 16-17

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See detailComparative clinical and electrometric assessments of the impact of surfactants on forearm skin.
Uhoda, Emmanuelle ULiege; Paye, Marc; Pierard, Gérald ULiege

in Exogenous Dermatology : Physical, Chemical, Biological (2003), 2

Surfactant-based skin care products can induce minimal to more severe alterations to human stratum corneum (SC). These changes can be conveniently assessed using electrometric devices. Four different ... [more ▼]

Surfactant-based skin care products can induce minimal to more severe alterations to human stratum corneum (SC). These changes can be conveniently assessed using electrometric devices. Four different surfactant-based solutions were applied on the forearms of 10 healthy volunteers following a soap chamber test method. The 2-day patch testing was followed by a 2-week follow-up. Clinical and instrumental assessments were performed at 7 time points. Data generated by the Corneometer® CM820, the DermaLab Moisture Module® and the Nova Dermal Phase Meter (DPM)® 9003 were compared. The significant differences between the product aggressiveness to the SC were similarly disclosed by the Corneometer® and the DermaLab Moisture Module®. The ranking of product aggressiveness given by the 3 devices 5 days after patch removal was similar to that given by the clinical assessment of erythema. A high level of correlation were found between the values yielded by the immediate and continuous mode assessments using the DermaLab Moisture Module with the Pin Probe, while the correlation was weaker with the Nova DPM®. This finding may be related to the fact that the Nova DPM is influenced by the accumulation of the transepidermal water loss in the continuous mode assessment while there is no significant occlusion effect of the DermaLab Moisture® Pin Probe that is more representative of the initial level of SC hydration. In conclusion, the Corneometer® and the DermaLab Moisture Module® respond similarly to changes in the SC content. This finding is different from some previous reports. [less ▲]

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See detailL'herpèsvirus alcélaphin 1, l'agent responsable de la forme africaine du coryza gangreneux
Dewals, Benjamin G ULiege; Boudry, Christel ULiege; Markine-Goriaynoff, Nicolas ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 1-15

Malignant catarrhal fever (MCF) is a pathology usually lethal which has been described in a large number of ruminant species. Based on the etiology, two main forms of MCF have been described, i.e., the ... [more ▼]

Malignant catarrhal fever (MCF) is a pathology usually lethal which has been described in a large number of ruminant species. Based on the etiology, two main forms of MCF have been described, i.e., the European and the African forms due to ovine herpesvirus 2 (OvHV-2) and alcelaphine herpesvirus 1 (AlHV-1), respectively. The present review is devoted to the African form of MCF and to its causative agent AlHV-1. AlHV-1 belongs to the Gammaherpesvirinae subfamily of the Herpesviridae family. Wildebeests (Connochaetes spp) carry AlHV-1, which is lethal for a large number of ruminant species, while apparently harmless to its natural host. In hosts susceptible to MCF, the pathology is characterized by fever, extensive lymphadenopathy, ulcerative lesions of the digestive and the upper respiratory tracts mucous membranes and severe keratoconjunctivitis. In the present paper, we will review the data available to date on AlHV-1 and on the African form of MCF with emphasis on the pathogenesis, clinical signs and anatomo-pathological lesions of MCF. Finally, we will discuss the relationship between AlHV-1 and wildebeest as an example of symbiosis between a virus and its natural host. [less ▲]

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See detailPoxviruses as vaccine vectors
Pastoret, Paul-Pierre ULiege; Vanderplasschen, Alain ULiege

in Comparative Immunology, Microbiology and Infectious Diseases (2003), 26

The discovery of Jenner in 1798 founded the science of immunology and eventually led to smallpox eradication from the earth in 1980 after a world-wide vaccination campaign with vaccinia virus (another ... [more ▼]

The discovery of Jenner in 1798 founded the science of immunology and eventually led to smallpox eradication from the earth in 1980 after a world-wide vaccination campaign with vaccinia virus (another poxvirus) and paradoxically, despite the eradication of smallpox, there has been an explosion of interest in vaccinia virus in the eighties. This interest has stemmed in part from the application of molecular genetics to clone and express foreign genes from recombinant vaccinia viruses. Vaccinia is also gaining renewed interest due to bioterrorism.These recombinant viruses have multiple applications in research and vaccinology and led to the development of vectored vaccines, such as the recombinant vaccinia rabies vaccine used to eliminate rabies in Western Europe and, more recently, in the United States. Secondly, alternative poxvirus vectors, such as avipox viruses, were proved to be even safer and efficacious non-replicating vectors (suiciole vectors) when used in non-avian species. [less ▲]

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See detailA low rate of trisomy 21 in twin-pregnancies: A cytogenetics retrospective study of 278 cases
Jamar, Mauricette ULiege; Lemarchal, C.; Koulischer, Lucien ULiege et al

in Genetic Counseling (2003), 14(4), 395-400

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See detailLes protéines de choc thermique (heat shock proteins). II Les protéines de choc thermique (heat shock proteins). II. Hsp70, biomarqueur, bioprotecteur.
Wirth, Delphine; Gustin, Pascal ULiege; Drion, Pierre ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(2), 127-144

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was ... [more ▼]

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was initially discovered in Drosophila. The genes hsps were among the first eukaryotic genes to be cloned and whose regulation, which involves activation of heat shock factor (HSF), was elucidated. More recently, study of Hsp functions, particularly Hsp70, started. Their protective role, related to their molecular chaperon function, was inferred from experiments showing that Hsp70 expression, induced by a first stress, results in a cellular tolerance to second stress. Better understanding of the heat shock response had led to the development of two search fields on Hsp70 expression : (1) its use as biomarker of cellular stress and (2) the exploitation of its cytoprotective functions against various insults. This review includes historic of the research on the heat shock response, description of regulation mechanism of Hsp70 expression, and the interesting perspectives allocated to Hsp70 as biomarker and therapeutic tool. ----------- L’exposition de tout organisme à des températures élevées induit l'expression cellulaire rapide et transitoire de protéines spécifiques, les protéines de choc thermique (Hsps pour " heat shock proteins "). Cette réponse des cellules au choc thermique ou " heat shock response " a été initialement découverte chez la drosophile. Les gènes hsps furent parmi les premiers gènes eucaryotes à être clonés et utilisés comme paradigme dans l'étude des mécanismes de régulation transcriptionnelle faisant intervenir l'activation d'un ou plusieurs " heat shock factors" (HSFs). C'est plus récemment que l'étude des fonctions des Hsps, particulièrement Hsp70, a débuté. Le rôle protecteur de celle-ci, lié à sa fonction de " chaperon " protéique, a été déduit d'expériences montrant que l'induction de l'expression de Hsp70 lors d'un stress était associée au développement d'une tolérance cellulaire vis-à-vis d'un stress ultérieur. En plus d'un intérêt fondamental pour la compréhension de la "réponse au choc thermique", deux axes de recherche appliquée se sont développés visant à investiguer la possibilité d'utiliser l'expression de Hsp70 comme biomarqueur de souffrance cellulaire d'une part et, d'autre part, d'exploiter ses fonctions comme moyen de protection des cellules contre divers types d'agressions. Cette revue décrit l'historique des découvertes sur la " réponse au choc thermique ", le mécanisme régulant l'expression de Hsp70 ainsi que les perspectives intéressantes s'ouvrant à l'utilisation de l'expression de Hsp70 en tant que biomarqueur et outil thérapeutique. [less ▲]

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See detailPour améliorer l'apprentissage d'une langue moderne à l'école primaire
Blondin, Christiane ULiege; Straeten, M.

in Point sur la Recherche en Education (Le) (2003), 27

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See detailReal sex in bacteria !
Gratia, Jean-Pierre; Thiry, Marc ULiege

in Microbiology Today (2003), 30

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See detailUne recherche-action pour développer les capacités de compréhension de l’écrit en 1re accueil … Premier bilan
Schillings, Patricia ULiege; Poncelet, Débora

in Point sur la Recherche en Education (Le) (2003)

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See detailRétention gazeuse dans une colonne à bulles contenant un liquide visqueux non-newtonien
Fransolet, Emmanuelle; Coumont, V.; Crine, Michel ULiege et al

in Tribune de l'Eau (La) (2003), 56(622), 15-20

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See detailSelection of the most efficient wavelength bands for 'Jonagold' apple sorting
Kleynen, O.; Leemans, Vincent ULiege; Destain, Marie-France ULiege

in Postharvest Biology & Technology (2003), 30(3), 221-232

This paper presents a method based on quadratic discriminant analysis to select the best filters for detecting a wide range of defects in 'Jonagold' apple fruit using a multi-spectral vision system ... [more ▼]

This paper presents a method based on quadratic discriminant analysis to select the best filters for detecting a wide range of defects in 'Jonagold' apple fruit using a multi-spectral vision system. Reflectance spectra of damaged and sound tissue were recorded using a visible/NIR spectrometer. Analysed defects consisted of scald, hail damage (with and without skin perforation), limb rubs, russets, scab tissue, frost damage, rot, visible flesh damage and recent bruises. Camera filter effects were approximated by summing the reflectances of all the wavelengths within the filter bandwidth. Combinations of three and four filters were tested and evaluated for discriminating damaged tissues from healthy ones. If a three-filter combination appeared sufficient to detect most of the damaged tissue, a four-filter combination should be considered for the complete sorting automation of this bicolour apple variety. A fourth filter was necessary to quantify the ratio between the blush and ground colours. Regarding recent bruise defects which represented the major difficulty, an image segmentation algorithm based on local contrast variations can enhance their detection. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailLe Musée en Piconrue de Bastogne
Donneau, Olivier ULiege

in Invitation au musée : Courrier du patrimoine culturel de la Communauté française (2003), 4

Courte présentation des activités du Musée en Piconrue de Bastogne.

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See detailDistinct T cell subsets and cytokine production in cultures derived from transformation zone and squamous intraepithelial lesion biopsies of the uterine cervix.
Jacobs, Nathalie ULiege; Renard, Isabelle; Al-Saleh, Walid et al

in American Journal of Reproductive Immunology (2003), 49(1), 6-13

PROBLEM: The characterization of lymphocytes issued from squamous intraepithelial lesions (SIL) and from the transformation zone (TZ), where the majority of SIL occur, is important to understand the role ... [more ▼]

PROBLEM: The characterization of lymphocytes issued from squamous intraepithelial lesions (SIL) and from the transformation zone (TZ), where the majority of SIL occur, is important to understand the role of immunity in SIL development. METHOD OF STUDY: We compared lymphocyte populations of the TZ and SIL with those of normal exocervix, using a technique allowing for the isolation of lymphocytes, either from the epithelium or from the underlying stroma of small biopsies. RESULTS: The majority of cells derived from the epithelium of all biopsies were CD8+ T cells. Some SIL-derived cultures were characterized by an increased proportion of activated TCRgammadelta+. The production of the immunosuppressive cytokine IL10 was significantly higher in lymphocyte cultures from the normal TZ in comparison with the exocervix. A decreased percentage of effector T cells was observed in cultures derived from the stroma of normal TZ (TCRgammadelta+) or SIL (CD8+) in comparison with the exocervix. CONCLUSIONS: Our results suggest that a low proportion of effector T cells and IL10 production could contribute to the predisposition of the TZ to the development of SIL and to the progression of SIL to cervical cancer. [less ▲]

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See detailCaractérisation génotypique de souches invasives aviaires d'Escherichia coli isolées en Belgique
Stordeur, P.; Beaupain, N.; Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 275-280

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See detailLa pustulose sous-cornee de Sneddon et Wilkinson.
Martalo, O.; Paquet, Philippe ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2003), 58(10), 628-30

The subcorneal pustular dermatosis of Sneddon and Wilkinson belongs to the heterogeneous group of neutrophilic dermatosis. This unique disorder is characterized by a superficial pustular eruption. The ... [more ▼]

The subcorneal pustular dermatosis of Sneddon and Wilkinson belongs to the heterogeneous group of neutrophilic dermatosis. This unique disorder is characterized by a superficial pustular eruption. The pustules are flaccid and aseptic. They develop predominantly on the trunk and in the groins, axillae and submammary areas. This disease is benign and chronic. However, it can be associated with some other conditions such as lymphoproliferative and myeloproliferative diseases. Dapsone is the treatment of choice to control the skin manifestations. [less ▲]

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See detailAnatomische, histologische en immunologische aspecten van de tonsille bij het schaap in het kader van de BSE problematiek
Cocquyt, G.; Gabriel, Annick ULiege; Van den Broeck, W.

in Vlaams Diergeneeskundig Tijdschrift (2003), 72

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See detailA magnetic and Mossbauer spectral study of TbFe11Ti and TbFe11TiH
Piquer, C.; Hermann, Raphaël ULiege; Grandjean, François-Xavier ULiege et al

in Journal of Physics : Condensed Matter (2003), 15(43), 7395-7409

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering ... [more ▼]

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering temperature, magnetization, magnetic hyperfine fields, and isomer shifts as a result of lattice expansion. Further, the insertion of hydrogen reinforces the basal magnetic anisotropy of the terbium sublattice and, as is shown by ac susceptibility measurements and thermomagnetic analysis, the spin reorientation observed in TbFe11Ti at 338 K disappears in TbFe11TiH. The Mossbauer spectra have been analysed with a model that considers both the easy magnetization direction and the distribution of titanium atoms in the near-neighbour environment of the three crystallographically distinct iron sites. The assignment and the temperature dependencies of the hyperfine fields and isomer shifts are in complete agreement with a Wigner-Seitz cell analysis of the three iron sites in RFe11Ti and RFe11TiH, where R is a rare-earth element. A complete analysis of the quadrupole interactions in both magnetic phases and in the paramagnetic phase of TbFe11Ti supports the Mossbauer spectral analysis, and indicates that in the basal magnetic phase the iron magnetic moments are oriented along the equivalent [100] and [010] directions of the unit cell. [less ▲]

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See detailL'euthanasie en Belgique et aux Pays-Bas
Leleu, Yves-Henri ULiege

in Revue Trimestrielle des Droits de l'Homme (2003)

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : I) les adhésines et facteurs de colonisation
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 105-126

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, enterohaemmorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections): If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains: adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This first manuscript presents the current knowledge on the receptors, roles in pathogenesis, structures, genetic determinism and identification methods of fimbrial adhesins of P (Pap, Prs), S (Sfa, F1C, Sfr) and F17 (Vir, Att25, FY, 20K, G, Att111) families and of afimbrial adhesins of Afa family (Afa, Nfa, F1845, Bma, Dr...). [less ▲]

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See detailChromomycose autochtone chez une patiente immunodéprimée.
Quatresooz, Pascale ULiege; Dethier, F.; Pierard, Gérald ULiege

in Dermatologie Actualité (2003), 74

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See detailEGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.
Teramoto, Tetsuyuki; Qiu, Jianhua; Plumier, Jean-Christophe ULiege et al

in Journal of Clinical Investigation (2003), 111(8), 1125-32

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that ... [more ▼]

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-labeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair. [less ▲]

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See detailHow ergodic is the fragmentation of the pyridine cation? A maximum entropy analysis
Gridelet, E.; Locht, Robert ULiege; Lorquet, Andrée ULiege et al

in International Journal of Mass Spectrometry (2003), 228(2-3), 389-402

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the ... [more ▼]

The kinetic energy released to the C4H4+ and HCN fragments produced by the dissociation of the pyridine ion has been determined by a retarding field technique up to an internal energy of 4eV above the reaction threshold. This extends our previous study limited to the metastable domain [Int. J. Mass Spectrom. Ion Process. 185/186/187 (1999) 155]. Retarding potential curves resulting from dissociative photoionization using the He(I), Ne(I), and Ar(II) resonance lines have been analyzed by the maximum entropy method. The comparison between the experimentally measured curves and those calculated for the prior (i.e., most statistical) situation reveals the existence of dynamical constraints that prevent phase space from being fully explored. The "ergodicity index" F(E) that measures the efficiency of phase space sampling as a function of the internal energy E of the molecular ion is found to decrease steadily as a function of E and to level off at a value of about 50% when E greater than or equal to 2.5 eV At these high internal energies where phase space exploration no longer decreases, spontaneous intramolecular vibrational energy redistribution (i.e., resulting from the anharmonicity of the molecular vibrations) is thought to contribute to internal energy randomization to a limited extent only. When the lifetime is short, phase space exploration is believed to result instead from the relaxation of the electronic energy via a cascade of non-radiative transitions, which leads to a great diversity of initial conditions, and thus, contributes to statisticity. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMycoplasma bovis : synthèse des connaissances actuelles
Thomas, Anne; Mainil, Jacques ULiege; Linden, Annick ULiege

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 23-39

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia ... [more ▼]

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia, arthritis and mastitis, and is thus associated with strong economic losses. Several studies have shown the frequency of M. bovis in Europe and the spread of antibiotic-resistant strains. Considering the absence of vaccine in Europe, it is essential to understand this bacteria in order to control the infection in cattle. In this context, this paper aims at summarizing the current knowledge about M. bovis. [less ▲]

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See detailMédecine d'une culture de paix et bioterrorisme.
Pierard, Gérald ULiege

in Dermatologie Actualité (2003), 79

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See detailPlmA, a new member of the GntR family, has plasmid maintenance functions in Anabaena sp. strain PCC 7120
Lee, M. H.; Scherer, K.; Rigali, Sébastien ULiege et al

in Journal of Bacteriology (2003), 185(15), 4315-4325

The filamentous cyanobacterium Anabaena (Nostoc) sp. strain PCC 7120 maintains a genome that is divided into a 6.4-Mb chromosome, three large plasmids of more that 100 kb, two medium-sized plasmids of 55 ... [more ▼]

The filamentous cyanobacterium Anabaena (Nostoc) sp. strain PCC 7120 maintains a genome that is divided into a 6.4-Mb chromosome, three large plasmids of more that 100 kb, two medium-sized plasmids of 55 and 40 kb, and a 5.5-kb plasmid. Plasmid copy number can be dynamic in some cyanobacterial species, and the genes that regulate this process have not been characterized. Here we show that mutations in an open reading frame, all1076, reduce the numbers of copies per chromosome of several plasmids. In a mutant strain, plasmids pCC7120delta and pCC7120zeta are both reduced to less than 50% of their wild-type levels. The exogenous pDU1-based plasmid pAM1691 is reduced to less than 25% of its wild-type level, and the plasmid is rapidly lost. The peptide encoded by all1076 shows similarity to members of the GntR family of transcriptional regulators. Phylogenetic analysis reveals a new domain topology within the GntR family. PlmA homologs, all coming from cyanobacterial species, form a new subfamily that is distinct from the previously identified subfamilies. The all1076 locus, named plmA, regulates plasmid maintenance functions in Anabaena sp. strain PCC 7120. [less ▲]

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See detailMetabolising risk: food scares and the un/re-making of Belgian beef
Stassart, Pierre M ULiege; Whatmore, Sarah J.

in Environment & Planning A (2003), 35

In this paper we explore the event of foodscares as an example of what Callon calls 'hot situations', in which the landscape of competing knowledge claims is at its most molten, and alternative production ... [more ▼]

In this paper we explore the event of foodscares as an example of what Callon calls 'hot situations', in which the landscape of competing knowledge claims is at its most molten, and alternative production and consumption practices galvanise new modes of sense-making against the market and state-sanctioned rationalities of industrialisation. Through a case study of the Belgian cooperative Coprosain and its meat products, we examine the 'stuff' of food as a ready messenger of connectedness and affectivity in which 'risk' is transacted as a property both of the growing distance between the spaces of production and consumption and of the enduring metabolic intimacies between human and nonhuman bodies. [less ▲]

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See detailLes marques de provenance des incunables conservés à la Bibliothèque royale de Belgique : essai de synthèse
Adam, Renaud ULiege

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in Belgie (2003), 75

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See detailAnalyse de la variabilité spatio-temporelle de la morphologie du chenal de la Warche en amont du barrage de Butgenbach (Belgique).
Assani, A. A.; Petit, François ULiege; Buffin-Belanger, T. et al

in Zeitschrift für Geomorphologie (2003)

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See detailPreoperative hyperfractionated acclerated radiotherapy (HART) and concomittant CPT-11 in advanced rectal carcinoma. A phase I study.
Voelter, V; Stupp, R; Matter, M et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 56(5), 1288-1294

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated ... [more ▼]

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated radiotherapy (HART). In this Phase I trial, we aimed at introducing chemotherapy early in the treatment course with both intrinsic antitumor activity and a radiosensitizer effect. Methods and Materials: Twenty-eight patients (19 males; median age 63, range 28–75) with advanced rectal carcinoma (cT3: 24; cT4: 4; cN : 12; M1: 5) were enrolled, including 8 patients treated at the maximally tolerated dose. Escalating doses of CPT-11 (30–105 mg/m2/week) were given on Days 1, 8, and 15, and concomitant HART (41.6 Gy, 1.6 Gy bid 13 days) started on Day 8. Surgery was to be performed within 1 week after the end of radiochemotherapy. Results: Twenty-six patients completed all preoperative radiochemotherapy as scheduled; all patients underwent surgery. Dose-limiting toxicity was diarrhea Grade 3 occurring at dose level 6 (105 mg/m2). Hematotoxicity was mild, with only 1 patient experiencing Grade 3 neutropenia. Postoperative complications (30 days) occurred in 7 patients, with an anastomotic leak rate of 22%. Conclusions: The recommended Phase II dose of CPT-11 in this setting is 90 mg/m2/week. Further Phase II exploration at this dose is warranted. © 2003 Elsevier Inc. [less ▲]

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See detailRole of catalase in ethanol-induced conditioned taste aversion : a study with 3-amino-1,2,4-triazole
Quertemont, Etienne ULiege; Escarabajal, M. Dolores; De Witte, Philippe

in Drug and Alcohol Dependence (2003), 70(1), 77-83

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain ... [more ▼]

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain metabolism of ethanol by the enzyme catalase. Therefore, the inhibition of catalase by 3-amino-1,2,4-triazole (aminotriazole) may help to clarify the involvement of acetaldehyde in ethanol's hedonic effects. In the present study, multiple doses of both ethanol and aminotriazole were used to investigate the effects of catalase inhibition on ethanol-induced conditioned taste aversion (CTA). A separate microdialysis experiment investigated the effects of aminotriazole pretreatment on the time course of brain ethanol concentrations. Ethanol induced a dose-dependent CTA with a maximal effect after conditioning with 2.0 g/kg ethanol. Aminotriazole pretreatments dose-dependently potentiated the CTA induced by 1.0 g/kg ethanol. However, aminotriazole pretreatments did not alter the CTA induced by higher ethanol doses (1.5 and 2.0 g/kg) probably because a maximal aversion for saccharin was already obtained without aminotriazole. The results of the microdialysis experiment confirmed that the effects of aminotriazole cannot be attributed to local alterations of brain ethanol levels. The present study argues against a role for brain acetaldehyde in ethanol's aversive effects but in favor of its involvement in ethanol rewarding properties. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailWriting and the Other Arts in Wilson Harris's Fiction
Maes-Jelinek, Hena ULiege

in Commonwealth : Essays and Studies (2003), SP 5

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See detailJean Michel-Bonvin : Figures de sociologues. Introduction à l'epistémologie sociologique
Jacquemain, Marc ULiege

in Schweizerische Zeitschrift für Soziologie = Revue Suisse de Sociologie (2003), 29

Jean-Michel Bonvin introduces the reader to the sociological method through the study of eight classical sociologists throught the 19th and 20th centurites : Comte, Tocqueville, Marx, Durkheim, Weber ... [more ▼]

Jean-Michel Bonvin introduces the reader to the sociological method through the study of eight classical sociologists throught the 19th and 20th centurites : Comte, Tocqueville, Marx, Durkheim, Weber, Simmel, Goffman and Parsons [less ▲]

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See detailNMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains.
Liepinsh, Edvards; Genereux, Catherine ULiege; Dehareng, Dominique ULiege et al

in Journal of Molecular Biology (2003), 327(4), 833-42

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway ... [more ▼]

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway for the acquisition of constitutive antibiotic resistance. Here, we report the NMR structure of AmpD from Citrobacter freundii (PDB accession code 1J3G). A deep substrate-binding pocket explains the observed specificity for low molecular mass substrates. The fold is related to that of bacteriophage T7 lysozyme. Both proteins bind zinc at a conserved site and require zinc for amidase activity, although the enzymatic mechanism seems to differ in detail. The structure-based sequence alignment identifies conserved features that are also conserved in the eukaryotic peptidoglycan recognition protein (PGRP) domains, including the zinc-coordination site in several of them. PGRP domains thus belong to the same fold family and, where zinc-binding residues are conserved, may have amidase activity. This hypothesis is supported by the observation that human serum N-acetylmuramyl-L-alanine amidase seems to be identical with a soluble form of human PGRP-L. [less ▲]

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See detailLes effets de la formation professionnelle continue : une enquête auprès des bénéficiaires des actions du Fonds social européen en Wallonie et à Bruxelles
Conter, Bernard; Maroy, Christian; Orianne, Jean-François ULiege

in Politiques d'Education et de Formation : Analyses et Comparaisons Internationales (2003), 7

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See detailEpidemiology, clinical presentation and diagnostic strategy of gastro-esophageal reflux
Louis, Edouard ULiege

in Acta Endoscopica (2003), 33

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : II) Franchissement des muqueuses et propriétés invasives
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(3, JUN-JUL), 159-171

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, entero-haemorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains : adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This second manuscript presents the current knowledge on the transmucosal transfer, resistance to the bactericidal activity of the complement, resistance to phagocytosis and production of colicins, that were, for several years, considered as an important specific property of invasive strains of E coli. [less ▲]

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See detailLoi du 2 août 2002 concernant la lutte contre le retard de paiement dans les transactions commerciales
Decharneux, Joëlle ULiege

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2003)

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See detailUne approche par les compétences pour l’apprentissage des soins infirmiers. Analyse des pratiques des enseignants.
Dury, Cécile ULiege

in Recherche en Soins Infirmiers (2003), 73(Juin), 4-40

The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non ... [more ▼]

The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non-directive approach. The data were analysed with a qualitative method: "structural analysis method". The results showed that their methods are in majority in a transmissive and behavioral model; an inadequacy between teaching methods and pedagogical goals; an abivalent and unclear understanding of their role; a lack of coherence in the assesment methods. To conclude, various strategies are proposed on institutional and national levels to support the implementation of a competence-based approach in nursing training. [less ▲]

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See detailFitting lactation curves of dairy cattle in different types of herds in Tunisia
Rekik, Boulbaba; Ben Gara, Abderrahmen; Ben Hamouda, Mohamed et al

in Livestock Production Science (2003), 83(2-3), 309-315

The incomplete gamma function was used to fit lactation curves of Holstein-Friesian cows in four types of herds in Tunisia. A total of 8640 records were used in the analysis. These included 1269, 637, 239 ... [more ▼]

The incomplete gamma function was used to fit lactation curves of Holstein-Friesian cows in four types of herds in Tunisia. A total of 8640 records were used in the analysis. These included 1269, 637, 239, and 498 first lactation and 2986, 1441, 650, and 920 second and later lactation records in four herd groups namely investors, state, cooperative, and farmers' herds, respectively. The effects of environmental variables, production sector, herd, parity, first test-day date, calving year, and calving season on the main lactation curve traits were analysed. The factors associated with milk yield at the beginning of lactation and the decreasing phase of the curve, persistency, and peak yield varied significantly (P<0.01) with all variables. The ascending phase of the lactation curve was not affected by parity and calving year, while days in milk until peak depended only on the rank of lactation. The state herds had the lowest peak and total yields. The summer season was unfavourable for milk production. In contrast to first lactation cows, third lactation cows had the highest peak and total yields. Milk yield was highly correlated with peak yield (r = 0.79) and was not related to persistency measure. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailLes mycoplasmes respiratoires bovins: prévalence et propriétés de cyto-adhésion
Thomas, A.; Dizier, Isabelle ULiege; SACHSE, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 267-272

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See detailBlending of hydrogenated low-erucic acid rapeseed oil, low-erucic acid rapeseed oil, and hydrogenated palm oil or palm oil in the preparation of shortenings
Danthine, Sabine ULiege; Deroanne, Claude ULiege

in Journal of the American Oil Chemists' Society (2003), 80(11), 1069-1075

Two ternary systems of fats were studied. In the first system, low-erucic acid rapeseed oil (LERO), hydrogenated low-erucic acid rapeseed oil (HLERO), and palm oil (PO) were blended. In the second system ... [more ▼]

Two ternary systems of fats were studied. In the first system, low-erucic acid rapeseed oil (LERO), hydrogenated low-erucic acid rapeseed oil (HLERO), and palm oil (PO) were blended. In the second system, hydrogenated palm oil (HPO) was used instead of PO and was blended with LERO and HLERO. The blends were then studied for their physical properties such as solid fat content (SFC), melting curves by DSC, and polymorphism (X-ray). HPO showed the highest melting enthalpy after 48 h at 15degreesC (141 +/- 1 J/g), followed by HLERO (131 +/- 2 J/g), PO (110 +/- 2 J/g), and LERO (65 +/- 4 J/g). Binary phase behavior diagrams were constructed from the DSC and X-ray results. Iso-line diagrams of partial-melting enthalpies were constructed from the DSC results, and binary and ternary isosolid diagrams were constructed from the NMR results. The isosolid diagrams demonstrated formation of a eutectic along the binary blend of PO/HLERO. However, no eutectic effect was observed along the binary lines of HPO/HLERO, PO/LERO, HPO/LERO, or HLERO/LERO. The same results were found with the iso-line diagrams of partial-melting enthalpies. As expected, addition of PO or HPO increased polymorphic stability in the beta' form of the HLERO/LERO mixture. [less ▲]

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See detailProcessing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.
De Cat, Bart; Muyldermans, Sin*-Ya; Coomans, Christien et al

in Journal of Cell Biology (2003), 163(3), 625-35

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 ... [more ▼]

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 core protein is processed by a furinlike convertase. This processing is essential for GPC3 modulating Wnt signaling and cell survival in vitro and for supporting embryonic cell movements in zebrafish. The processed GPC3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical Wnt signaling additionally require substitution of the core protein with heparan sulfate. Wnt 5A physically associates only with processed GPC3, and only a form of GPC3 that can be processed by a convertase is able to rescue epiboly and convergence/extension movements in GPC3 morphant embryos. Our data imply that the Simpson-Golabi-Behmel syndrome may in part result from a loss of GPC3 controls on Wnt signaling, and suggest that this function requires the cooperation of both the protein and the heparan sulfate moieties of the proteoglycan. [less ▲]

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See detailQuelle formation andragogique pour les enseignants universitaires demain ?
Schmitz, Serge ULiege

in Actes du Geoforum (2003), 27

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See detailChoice of an adjuvant for vaccination trials
Vermout, Sandy; Denis, M.; Losson, Bertrand ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(6), 393-401

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it ... [more ▼]

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it qualitatively. A number of tumors and infectious diseases could be treated with adjuvant preparations that would adequately intensify and modulate specific immune response; in particular, the possibility to specifically induce a Th1 response seems to be of paramount importance for the prevention and for the cure of these diseases. Furthermore, these adjuvants must be as safe as possible, not only for commercial applications, but also in the respect of laboratory animals' welfare. This review describes the different adjuvants presently used in vaccinology, classifying them following their chemical nature and presenting for each category the knowledge concerning their activity and toxicity. [less ▲]

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See detailLa servitude légale d'enclave : un tour d'horizon
Boufflette, Sophie ULiege

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2003)

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See detailUne approche neuropsychologique des relations entre mémoire épisodique et mémoire sémantique
Bastin, Christine ULiege; Van der Linden, Martial ULiege

in Revue de Neuropsychologie (2003), 13(1), 3-69

Cognitive models of the organization of memory propose different conceptions of the relationships between episodic and semantic memory. In the present review, we consider two influential models. According ... [more ▼]

Cognitive models of the organization of memory propose different conceptions of the relationships between episodic and semantic memory. In the present review, we consider two influential models. According to one model (Tulving, 1995), episodic and semantic memory are two functionally and anatomically distinct systems. Their relationships are referred to as “embeddedness”, that is, information must be encoded in semantic memory in order to achieve episodic memory. Another model (Squire & Zola, 1998) describes episodic and semantic memory as two subsystems of declarative memory. Both depend on the same brain region and should be impaired in amnesic patients. Furthermore, information is usually first encoded in episodic memory, before being transferred to semantic memory. In this review, we describe the neuropsychological data that support each model, as well as studies that contradict these models. Three sets of evidence are described. First, we consider recognition memory in amnesic patients. Recognition memory processes, recollection and familiarity, have been related to episodic and semantic memory, respectively (Tulving, 1995). Contradictory findings exist concerning the relative preservation of familiarity-based recognition in certain types of amnesic patients. Then we describe studies that have examined whether amnesic patients can learn new semantic information or not. Finally, episodic learning in semantic dementia is considered. [less ▲]

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See detailInositol 1,3,4,5-tetrakisphosphate is essential for normal T lymphocyte development
Pouillon, V.; Hascakova-Bartova, R.; Pajak, B. et al

in Nature Immunology (2003), 4

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4 ... [more ▼]

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4) is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5)P(3) amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development [less ▲]

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See detailOvero lethal white syndrome - two case reports and a review of the litterature
Sandersen, Charlotte ULiege; Delguste, Catherine ULiege; Cassart, Dominique ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(5, OCT-NOV), 359-364

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See detailIntensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al

in Blood (2003), 102(13), 4284-4289

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]

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See detailSedimentary deposition rates and carbon-14: The epi-paleolithic sequence of Okuzini Cave (southwest Turkey)
Otte, Marcel ULiege; López Bayón, Ignacio; Noiret, Pierre ULiege et al

in Journal of Archaeological Science (2003), 30(3), 325-341

A series of radiocarbon dates systematically obtained from bone and charcoal samples from the stratigraphic sequence of Okuzini Cave has been analyzed in conjunction with stratigraphic and archaeological ... [more ▼]

A series of radiocarbon dates systematically obtained from bone and charcoal samples from the stratigraphic sequence of Okuzini Cave has been analyzed in conjunction with stratigraphic and archaeological data to interpret the rates and processes of deposition and human occupation of the cave during the Epipaleolithic of southwest Turkey. AMS dates obtained on the charcoal series reveal the existence of three stratigraphic gaps. Sedimentation rates for the deposits are evaluated in relation to radiometric determinations, the nature and origin of sediment accumulation, the structure of the faunal and lithic assemblages and the changing nature of human occupation of the cave. A hypothesis is proposed to explain the processes and rates of sedimentation, including the three gaps revealed by the radiometric series. One of our aims is to caution against interpretations of cultural evolution directly linked to sedimentary rates for which the variation is not immediately evident during excavation, but which requires a more critical analysis, as we have had the opportunity to do at Okuzini. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailMycoplasma bovis dans le complexe respiratoire bovin et propriétés de cyto-adhésion in vitro
Thomas, Anne; Dizier, Isabelle ULiege; Sachse, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 267-272

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This ... [more ▼]

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This species was frequently isolated in Belgium from cattle with respiratory disease. Furthermore, associations were often observed with pasteurellas and bovine respiratory syncytial virus. Of these M. bovis isolates, many were resistant to several antimicrobial agents which are used in cattle practice, except to fluoroquinolones. Inasmuch the high frequency of M. bovis isolation and antibiotic resistances, it is very important to understand the pathogenicity of this bacteria in order to optimize prophylactic tools. Therefore, the study of the cytadherence of M. bovis is essential since it represents the first step of the bacterial infection. According to our experimental results, PG45 is not representative of field isolates because of its low adherence rates to various cell lines. This could be explained by the high number of subcultures of this pathogenic strain underwent since its first isolation, which sharply contrasts with other isolates. M. bovis adheres specifically to bovine bronchial epithelial cells in primary culture. Proteins such as variable surface proteins C and F are involved in this step as observed by decreased adherence rates after trypsinization of mycoplasma cells or addition of monoclonal antibodies. [less ▲]

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See detailSylviculture et qualité du bois de l'épicéa en Région wallonne. Recommandations pratiques - Cahier technique n°22
Hebert, Jacques ULiege; Herman, M.; Jourez, B.

in Forêt Wallonne (2003), (62), 10-13

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See detailAmélioration de la détection d’une maladie émergente : exemple de l’ encépahlopathie spongiforme bovine
Saegerman, Claude ULiege; Berkvens, D.; Speybroeck, N. et al

in Epidémiologie et Santé Animale (2003), 44

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See detailRecognizing and interpreting the fossils of early eukaryotes
Javaux, Emmanuelle ULiege; Knoll, A. H.; Walter, M.

in Origins of Life & Evolution of the Biosphere (2003), 33(1), 75-94

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context ... [more ▼]

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context of early eukaryotic diversification. For this reason, recognition of eukaryotic fossils in Proterozoic rocks is key to the integration of geological and comparative biological perspectives on protistan evolution. Microfossils preserved in shales of the ca. 1500 Ma Roper Group, northern Australia, display characters that ally them to the Eucarya, but, at present, attribution to any particular protistan clade is uncertain. Continuing research on wall ultrastructure and microchemistry promises new insights into the nature and systematic relationships of early eukaryotic fossils. [less ▲]

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See detailFrom the germinal cells to the newborn animal: The transmission of genes and life through the generations
Drion, Pierre ULiege; Szenci, Otto; Ectors, Fabien ULiege et al

in Acta Veterinaria Hungarica (2003), 51(3), 371-384

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most ... [more ▼]

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most spectacular manipulations are cloning and transgenesis. This review focuses on the early appearance of germinal cell precursors and the long-standing fate of gametes in mammals. The evident complexity and long-term programming of events in gametes and early embryos explain part of the difficulties encountered during the development of in vitro and in vivo methods such as multiple Ovulation and embryo transfer (MOET), oestrus synchronisation, ovulation induction, superovulation, in vitro maturation and fertilisation, cryopreservation, transgenesis, nuclear transfer and cloning) and the occurrence of unexpected alterations of development, e.g. embryonic or fetal mortality, large-weight newborn syndrome and other dysregulations ill imprinting or DNA transmission. [less ▲]

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See detailRilke herlezen
Spinoy, Erik ULiege

in Freespace Nieuwzuid (2003), 3(12), 80

In this special issue, a number of critics reflect on the question if and how it is still possible today to take great lyrical poetry at face value. The case at hand is that of Rilke's Duino Elegies.

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See detailEffets de la nicotine et du cannabis sur le systeme nerveux central.
Seutin, Vincent ULiege

in Revue Médicale de Liège (2003), 58(1), 19-21

We describe the molecular mechanisms of action of nicotine and delta 9-tetrahydrocannabinol, the most potent component of cannabis. Like other drugs of abuse, these compounds enhance dopamine release in a ... [more ▼]

We describe the molecular mechanisms of action of nicotine and delta 9-tetrahydrocannabinol, the most potent component of cannabis. Like other drugs of abuse, these compounds enhance dopamine release in a precise area of the limbic system when administered acutely. It has recently been shown that the cannabinoid receptors on which delta 9-tetrahydrocannabinol acts are also activated by endogenous ligands such as anandamide. This unconventional neurotransmitter appears to have important physiological effects in the central nervous system. Both preclinical and clinical evidence suggests that nicotine is more addictive than delta 9-tetrahydrocannabinol. However, the intimate interactions that exist between cannabinoid and opioid systems within the brain suggest that cannabinoids should not be considered as harmless drugs of abuse. [less ▲]

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See detailLes décrets oraculaires pris en l’honneur d’Hénouttaouy et de Maatkarê (Xe et VIIe pylônes)
Winand, Jean ULiege

in Cahiers de Karnak (2003), (11), 603-710

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See detailComments on Pouillot, R., Gerbier, G. & Gadner, I.A. “TAGS”, a program for the evaluation of test accuracy in the absence of a gold standard
Berkvens, D. L.; Speybroeck, N.; Lesaffre, E. et al

in Preventive Veterinary Medicine (2003), 59

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See detailRezension zu Silke Schlichtmann: Geschlechterdifferenz in der Literaturrezeption um 1800? Zu zeitgenössischen Goethe-Lektüren
Pontzen, Alexandra ULiege

in Arbitrium: Zeitschrift fuer Rezensionen zur germanistischen Literaturwissenschaft (2003)

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See detail1st Belgian geographical day
Schmitz, Serge ULiege; Meert, Henk

in Belgeo (2003), (3), 229-342

This special issue results from the 1st geographical day organized in Liege on March 2013.

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See detailDendrochronologie et archéologie du bâtiment
Hoffsummer, Patrick ULiege

in Cahiers de l'Urbanisme (Les) (2003), 44

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See detailDuplex ultrasound as first-line screening test for patients suspected of renal artery stenosis: prospective evaluation in high-risk group.
NCHIMI LONGANG, Alain ULiege; Biquet, J. F.; Brisbois, D. et al

in European Radiology (2003), 13(6), 1413-9

Our objective was to assess how far the progress in ultrasound devices has increased feasibility and accuracy of Duplex ultrasound (DUS) for the diagnosis of renal artery stenosis (RAS), in a population ... [more ▼]

Our objective was to assess how far the progress in ultrasound devices has increased feasibility and accuracy of Duplex ultrasound (DUS) for the diagnosis of renal artery stenosis (RAS), in a population with high prevalence of atherosclerotic renovascular lesions. Ninety-one hypertensive patients with atherosclerotic disease were prospectively evaluated by both DUS and digital subtraction angiography (DSA) of the renal arteries. Only proximal criteria (peak systolic velocity >180 mm/s or renal-to-aortic ratio >3.5) were used for the diagnosis of significant RAS (>60% narrowing). For both techniques, two readers were involved for interobserver variability study. Two hundred one arteries were demonstrated by DSA on 182 available kidneys. The prevalence of RAS among the study group was 37%. Sixteen of the 19 accessory arteries were not seen at DUS; in 8 patients, one renal artery was not seen at DUS (feasibility 91%). On the 177 arteries assessed, in comparison with DSA, DUS yielded 96, 91, and 97% mean values of accuracy, sensitivity, and specificity, respectively. Kappa for interobserver agreement was 0.95 for DUS and 0.92 for DSA. Although still unreliable for the detection of accessory arteries, DUS is in our experience an accurate and reproducible diagnostic test for RAS. [less ▲]

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See detailEnantiomeric separation of aminoglutethimide by capillary electrophoresis using native cyclodextrins in single and dual systems
Abushoffa, A. M.; Fillet, Marianne ULiege; Marini Djang'Eing'A, Roland ULiege et al

in Journal of Separation Science (2003), 26(6-7), 536-542

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A ... [more ▼]

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A complete resolution of the enantiomers of this compound in cationic form could be achieved with each of the three CDs, using a pH 3 phosphoric acid-triethanolamine buffer. Affinity constants for AGT enantiomers with the three native CDs were determined, confirming that the highest selectivity was given by gamma-CD while the strongest complexation was obtained with beta-CD. However, an opposite affinity pattern was observed with the latter. Selectivity was lower for AGT enantiomers in dual CD systems, compared to that obtained with a single selector at its optimal concentration, which confirms that dual systems are of more limited interest when the two selectors have a similar effect on the analyte mobility. These results are in good agreement with those predicted using recently developed mathematical models. [less ▲]

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See detailUltrasound appearance of bowel wall in Wolman's disease.
NCHIMI LONGANG, Alain ULiege; Rausin, Leon; Khamis, Jamil

in Pediatric Radiology (2003), 33(4), 284-5

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See detailFactor V inhibitor after injection of human thrombin in a bleeding ulcer.
Caers, Jo ULiege; Reekmans, An; Jochmans, Kristin et al

in Endoscopy (2003), 35((6)), 542-4

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See detailLe Robinier faux-acacia en Wallonie : utopie ou réalité? Premiers résultats
Fourbisseur, Anne; Devillet, Stéphane; Jourez, Benoît ULiege et al

in Forêt Wallonne (2003), (67), 12-23

Malgré son grand potentiel technologique et écologique, le Robinier faux-acacia (Robinia pseudacacia L.) est une essence sinon méconnue, du moins négligée en Région wallonne. Dans le contexte actuel où la ... [more ▼]

Malgré son grand potentiel technologique et écologique, le Robinier faux-acacia (Robinia pseudacacia L.) est une essence sinon méconnue, du moins négligée en Région wallonne. Dans le contexte actuel où la notion de gestion durable s’est imposée, certaines de ses propriétés, notamment écologiques, ouvrent la voie à une plus grande prise en considération de l’espèce. De plus, le robinier présente des caractéristiques remarquables, liées à sa vitesse de croissance et aux propriétés de son bois, et est susceptible, dans une certaine mesure, de trouver des débouchés très valorisants, par exemple dans des emplois réservés jusqu’à présent aux bois tropicaux. Cette essence mérite certainement un intérêt particulier, d’autant plus que la littérature ne présente pas d’argument précis en sa défaveur. La présence d’épines et la nécessité d’améliorer la morphologie de l’arbre ne sont certes pas des raisons suffisantes pour justifier l’absence d’expérimentation sylvicole en Région wallonne, mis à part les dispositifs installés voilà maintenant deux ans par l’Unité de Gestion des Ressources forestières et des Milieux naturels de la Faculté universitaire des Sciences agronomiques de Gembloux (FUSAGx) et par le Centre de Recherche de la Nature, des Forêts et du Bois, Direction de Technologie <br />du Bois (CRNFB, DTB). Un programme d’amélioration génétique pourrait en parallèle générer en quelques années un matériel de qualité en s’inspirant des recherches menées en Hongrie, pays à la pointe en matière de gestion du Robinier faux- acacia. Pour répondre à l’attente des estionnaires privés et publics, nous présentons une synthèse des connaissances relatives au robinier. Dans ce but, nous tenterons d’abord de cerner ses exigences stationnelles, et nous en déduirons les potentialités d’implantation de l’essence en Wallonie. Nous décrirons ensuite <br />la sylviculture appliquée au robinier en Hongrie et en France, pays réputés pour leur expérience dans le domaine, et verrons dans quelle mesure il est possible de profiter de cette expérience en Région wallonne. Nous détaillerons enfin les possibilités de valorisation de son bois. Les premiers résultats issus des dispositifs expérimentaux de sylviculture mis en place par la FUSAGx depuis <br />2 ans en Région wallonne seront inclus dans cet état des lieux et comparés aux expériences étrangères. [less ▲]

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See detailSkin weathering and ashiness in black Africans.
Uhoda, Emmanuelle ULiege; Pierard, Claudine ULiege; Petit, Ludivine et al

in European Journal of Dermatology (2003), 13(6), 574-8

Ashiness describes a common physiological skin condition that may develop in people with dark skin complexion. Environmental influences, particularly cold and dry weather, seem obvious. This condition has ... [more ▼]

Ashiness describes a common physiological skin condition that may develop in people with dark skin complexion. Environmental influences, particularly cold and dry weather, seem obvious. This condition has seldom been studied so far. In the present study, skin ashiness was assessed in 37 black African women by means of colorimetric assessments and xerosis ratings. Colour changes were measured by the parameters a* and the individual typology angle ITA degrees. Xerosis was assessed by visual inspection, the ultraviolet light-enhanced visualization (ULEV) method, and the cyanoacrylate skin surface stripping (CSSS) method. The assessments were performed on ashy skin of the legs and on the normal looking forehead during the winter season. Ashy skin was lighter but not erythematous. The ITA-revealed colour changes were correlated with xerosis severity as assessed by dry dermoscopy and by the ULEV and CSSS methods. In conclusion, ashiness due to skin weathering does not appear to be related to mild inflammation. It corresponds to a peculiar type of xerosis with reduction in Fresnel reflection by the stratum corneum. [less ▲]

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : III) Production de toxines
Van Bost, S.; Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(5, OCT-NOV), 327-342

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, enterohaemmorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains: adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This third manuscript presents the current knowledge on toxins produced by invasive strains of E. coli: endotoxins, cytotoxic necrotising factors, cytolethal distending toxins and haemolytic toxins. [less ▲]

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See detailSyncope sur passage en tachycardie ventriculaire par accélération d’une fibrillation auriculaire
Guillaume, T.; Melon, Pierre ULiege; Bouffioux, Laurent ULiege et al

in Revue Médicale de Liège (2003), 58(7-8), 468-471

We report a rare case of rapid atrial fibrillation triggering an episod of ventricular tachycardia. We review the literature and discuss the potential mechanisms of the ventricular arrhythmia.

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See detail« ‘Soñar, recordar y vivir con eso’. Los sueños de los Záparas en la construcción del pasado, Amazonia Ecuatoriana »,
Bilhaut, Anne-Gaël ULiege

in Estudios Atacameños (2003), 26

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental ... [more ▼]

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental role in their daily life. We will see how their history is constructed by means of dream experiences, and how these are used strategically in the present. Dreams, furthermore, guarantee the cultural and ritual continuity of this group on the verge of extinction. [less ▲]

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See detailBioactive capsular polysaccharide from the thermophilic Mastigocladus laminosus (Cyanophyceae/Cyanobacteria): demonstration of anti-inflammatory properties
Gloaguen, Vincent; Garbacki, Nancy ULiege; Petit, Daniel et al

in Algological Studies (2003), 108

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See detailRénovation de rites : de la critique du vers au vers critique
Purnelle, Gérald ULiege

in Balises, Cahiers de poétique des Archives et musée de la littérature (2003), 3-4

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See detailA recombinant 31.5 kDa keratinase and a crude exo-antigen from Microsporum canis fail to protect against a homologous experimental infection in guinea pigs.
Descamps, Frederic F; Brouta, Frederic; Vermout, Sandy M et al

in Veterinary Dermatology (2003), 14(6), 305-312

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three ... [more ▼]

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three times at two-week intervals with either the keratinase, the exo-antigen or the adjuvant alone. Cutaneous challenge was performed blindly. Both humoral and cellular-specific immune responses to M. canis antigens were evaluated every 14 days, while a blind evaluation of clinical lesion development and fungal persistency in skin were monitored weekly. Vaccination induced very high and significant (P < 0.01) antibody responses towards both antigens. High cell-mediated immune responses to both immunogens were also induced by vaccination. After challenge, however, scores reflecting the severity of dermatophytic lesions did not differ significantly between vaccinated and control groups at any time after challenge. These results suggest that, in the guinea pig, the induction of specific immune responses against the M. canis-secreted antigens used in this study are not protective against challenge exposure. [less ▲]

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See detailRéflexions sur l'idée de la "confiance mutuelle"
Flore, Daniel ULiege

in L'espace pénal européen (2003)

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See detailUtilisation des scories métallurgiques en dynamique fluviale : détermination de la compétence effective des rivières et estimation des vitesses de progression de la charge de fond.
Houbrechts, Geoffrey ULiege; Petit, François ULiege

in Géomorphologie : Relief, Processus, Environnement (2003), (1), 3-12

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées ... [more ▼]

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées par les anciens fondeurs dans les rivières, ont été soumises, pendant plusieurs siècles, à de nombreuses crues mobilisatrices. Par conséquent, elles peuvent être considérées comme un marqueur représentatif de la compétence effective des rivières sur une très longue période et sur une grande distance. Ainsi, en comparant la taille des scories en amont et en aval d’un secteur de pertes karstiques (plusieurs kilomètres), nous avons montré que ces pertes n’entraînent pas de baisse sensible de la compétence de la rivière. Une relation entre la taille des scories prélevées et les puissances spécifiques développées dans les secteurs de prélèvement a également été établie. Cette relation montre que le maximum de puissance spécifique des rivières ardennaises se produit dans les rivières dont le bassin versant est voisin de 150 km². Finalement, des scories retrouvées dans l’Ourthe, environ 10 km en aval du site de production le plus proche, ont été utilisées pour évaluer la vitesse de progression de la « vague sédimentaire ». En effet, ces scories sont soumises aux mêmes conditions hydrologiques et de piégeage que les éléments naturels de la charge de fond. Après avoir daté le début du fonctionnement du site de production le plus proche (1450), nous avons calculé la vitesse de progression des scories qui est comprise entre 1,8 et 2,3 km/siècle. [less ▲]

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See detailRuthenium catalysts bearing N-heterocyclic carbene ligands in atom transfer radical reactions
Richel, Aurore ULiege; Delfosse, Sébastien ULiege; Cremasco, Cédric et al

in Tetrahedron Letters (2003), 44(32), 6011-6015

The catalytic activity of ruthenium-p-cymene complexes bearing N-heterocyclic carbene ligands in atom transfer radical addition (ATRA) or polymerisation (ATRP) strongly depends on the substituents of the ... [more ▼]

The catalytic activity of ruthenium-p-cymene complexes bearing N-heterocyclic carbene ligands in atom transfer radical addition (ATRA) or polymerisation (ATRP) strongly depends on the substituents of the carbene ligand, thereby providing a nice illustration of the importance of organometallic engineering and ligand fine tuning in homogeneous catalysis. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailHydrodynamique et morphologie d'une bactérie filamenteuse dans un fermenteur à cuve agitée
Groslambert, Sylvie ULiege; Blacher, Silvia ULiege; Crine, Michel ULiege

in Tribune de l'Eau (La) (2003), 56(622), 58-64

Afin d'étudier l'influence de l'hydrodynamique sur une bactérie filamenteuse, Actinomadura R39, nous l'avons cultivée dans un fermenteur de laboratoire de 5 litres à cuve agitée en faisant varier les ... [more ▼]

Afin d'étudier l'influence de l'hydrodynamique sur une bactérie filamenteuse, Actinomadura R39, nous l'avons cultivée dans un fermenteur de laboratoire de 5 litres à cuve agitée en faisant varier les conditions d'agitation. Les variables sont la vitesse de rotation et le type de mobile utilisé: turbines Rushton ou Intermig. Les deux mobiles se distinguent par leur géométrie et par les schémas d'écoulement qu'ils induisent dans la cuve. L'influence de l'hydrodynamique sur Actinomadura R39 est quantifiée par l'évolution de sa morphologie. Cette dernière est estimée par analyse d'images sur des échantillons prélevés lors des cultures. Parallèlement, nous avons caractérisé l'hydrodynamique du fermenteur dans un milieu artificiel reproduisant la rhéologie des fermentations en mesurant la puissance dissipée et en effectuant des essais de traceurs. Ces derniers sont utilisés pour la modélisation du fermenteur par un modèle compartimenté et le calcul du temps de mélange. Nous avons pu ainsi mettre en relation les modifications de la morphologie et des grandeurs caractérisant les écoulements dans le fermenteur. L'existence de corrélations entre les paramètres du modèle et la morphologie a également permis une validation de la signification physique de ce modèle. [less ▲]

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See detailUn droit pénal européen : hasard ou nécessité
Flore, Daniel ULiege

in Revue de Droit Pénal et de Criminologie (2003), 9

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See detailEuropean COST action F3 on structural dynamics. Working group 3: identification of non-linear systems. Introduction and conclusions
Golinval, Jean-Claude ULiege; Kerschen, Gaëtan ULiege; Lenaerts, Vincent et al

in Mechanical Systems & Signal Processing (2003)

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See detailNieuwe Europese richtlijnen voor de behandeling van arteriele hypertensie: plaats van laaggedoseerde combinatiepreparaten
Krzesinski, Jean-Marie ULiege

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2003), 15(8), 295-299

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See detailA la recherche d'une langue perdue
Boutier, Marie-Guy ULiege

in Bulletin de la Commission Royale de Toponymie et de Dialectologie = Handelingen van de Koninklijke Commissie voor Toponymie en Dialectologie (2003), 75

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See detailDevelopment Of A Scar Marker And A Semi-Selective Medium For Specific Quantification Of Pichia Anomala Strain K On Apple Fruit Surfaces
De Clercq, Deborah; Cognet, Stephane; Pujol, Marta et al

in Postharvest Biology & Technology (2003), 29(3), 237-247

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See detailUltradispersity of diamond at the nanoscale
Raty, Jean-Yves ULiege; Galli, G.

in Nature Materials (2003), 2(12), 792-795795

Nanometre-sized diamond has been found in meteorites, protoplanetary nebulae, and interstellar dusts, as well as in residues of detonation and in diamond films. Remarkably, the size distribution of ... [more ▼]

Nanometre-sized diamond has been found in meteorites, protoplanetary nebulae, and interstellar dusts, as well as in residues of detonation and in diamond films. Remarkably, the size distribution of diamond nanoparticles seems to be peaked around 2-5 nm, and to be largely independent of preparation conditions. We have carried out ab initio calculations of the stability of nanodiamond as a function of surface hydrogen coverage and of size. We have found that at about 3 nm, and for a broad range of pressures and temperatures, particles with bare, reconstructed surfaces become thermodynamically more stable than those with hydrogenated surfaces, thus preventing the formation of larger grains. Our findings provide an explanation of the size distribution of extraterrestrial and of terrestrial nanodiamond found in ultradispersed and ultracrystalline diamond films. They also provide an atomistic structural model of these films, based on the topology and structure of 2-3 nm diamond clusters consisting of a diamond core surrounded by a fullerene-like carbon network [less ▲]

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See detailRisque cardiovasculaire global: HOPE fait vivre plus longtemps
Krzesinski, Jean-Marie ULiege

in Tempo Médical (2003), 247

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les ... [more ▼]

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les recommandations les plus récentes vont de plus en plus dans le sens d'une prise en charge du risque cardiovasculaire global, accordant moins d'importance à la valeur absolue de chacun des facteurs de risque; les patients présentant le plus grand risque global devant, bien entendu, être prioritairement traités. Une attitude, basée sur les résultats de quelques grandes études cliniques, dont HOPE (Heart Outcomes Prevention Evaluation). Nous vous proposons ici un rappel des résultats de cette étude remarquable, ainsi qu'un commentaire sur cette nouvelle approche préventive du risque CV, en compagnie de quelques uns des orateurs du congrès Cardio 2003. [less ▲]

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See detailChanges in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine.
Legssyer, Rachida; Josse, Claire ULiege; Piette, Jacques ULiege et al

in Journal of Inorganic Biochemistry (2003), 94(1-2), 36-42

Both desferrioxamine (DFO) and chloroquine can significantly reduce hepatic iron in experimental animals with iron overload by chelating iron from the low-molecular-weight pool or decreasing iron uptake ... [more ▼]

Both desferrioxamine (DFO) and chloroquine can significantly reduce hepatic iron in experimental animals with iron overload by chelating iron from the low-molecular-weight pool or decreasing iron uptake by the transferrin-transferrin receptor cycle, respectively. However, no previous studies have investigated whether combination therapy of these two drugs would further decrease the tissue iron overload as well as iron-induced toxicity. Chloroquine administration, 15 mg/kg, 5x/week, to rats during the iron loading regime, 10 mg/kg, 3x/week for 4 weeks, significantly decreased both hepatic (54%) and macrophage iron content (24%). However when administered in combination with desferrioxamine, 10 mg/kg, 3x/week for 2 weeks at the cessation of iron loading, no further reduction of hepatic iron content was noted while the iron content of the macrophages significantly increased, possibly indicating the flux of ferrioxamine through these cells. Further studies are warranted to investigate the speciation of iron within these macrophages. Macrophages isolated from chloroquine-treated iron loaded rats showed a reduction in latent NFkappaB activation and a significant increase in lipopolysaccharide-stimulated nitrite release by comparison to these parameters in iron loaded macrophages. Co-administration of chloroquine and desferrioxamine normalised the latent activity of NFkappaB to that of control macrophages as well as increasing LPS-stimulated NO release towards control values. However, DFO alone did not have any significant effect upon either of these parameters. Such results may have important relevance for the reduced immune function of iron loaded macrophages isolated from thalassaemia patients receiving chelation therapy and their propensity to increased infection. [less ▲]

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