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See detailEmerging Roles for Proteinases in Cancer
Noël, Agnès ULg; Gilles, Christine ULg; Bajou, Khalid ULg et al

in Invasion & Metastasis (1997), 17(5), 221-39

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these ... [more ▼]

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these processes was initially thought to be the destruction of extracellular matrices. However, recent evidence suggests that they mainly affect tumor growth rather than invasion. Proteinases can indeed generate active matrix protein fragments, influence the release, the activation and the bioavailability of growth factors, and consequently modulate tumor cell growth, apoptosis and angiogenesis. Additionally, proteinases, their receptors and/or inhibitors can be directly involved in cell migration and in the processing or shedding of cell surface proteins. Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies. [less ▲]

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See detailSur les accents et les marques de quantité dans les papyrus latins
Rochette, Bruno ULg

in Zeitschrift für Papyrologie und Epigraphik (1997), 119

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See detailMolecular dissection of the insulin-like growth factor axis in the human thymus
Geenen, Vincent ULg; Kecha, Ouafae; Achour, Imane et al

in Diabetologia (1997), 40

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See detailImplication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.
Gilles, Christine ULg; Polette, M.; Seiki, M. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1997), 76(5), 651-60

We have previously demonstrated that fibroblasts and invasive human breast carcinoma (HBC) cells specifically activate matrix metalloproteinase-2 (MMP-2) when cultured on 3-dimensional gels of type I ... [more ▼]

We have previously demonstrated that fibroblasts and invasive human breast carcinoma (HBC) cells specifically activate matrix metalloproteinase-2 (MMP-2) when cultured on 3-dimensional gels of type I collagen but not a range of other substrates. We show here the constitutive expression of membrane-type 1 (MT1)-MMP in both fibroblasts, and invasive HBC cell lines, that have fibroblastic attributes presumably acquired through an epithelial-to-mesenchymal transition (EMT). Treatment with collagen type I increased the steady-state MT1-MMP mRNA levels in these cells but did not induce either MT1-MMP expression or MMP-2 activation in noninvasive breast carcinoma cell lines, which retain epithelial features. Basal MT3-MMP mRNA expression had a pattern similar to that of MT1-MMP but was not up-regulated by collagen. MT4-MMP mRNA was seen in both invasive and noninvasive HBC cell lines and was also not collagen-regulated, and MT2-MMP mRNA was not detected in any of the HBC cell lines tested. These data support a role for MT1-MMP in the collagen-induced MMP-2-activation seen in these cells. In situ hybridization analysis of archival breast cancer specimens revealed a close parallel in expression of both collagen type I and MT1-MMP mRNA in peritumoral fibroblasts, which was correlated with aggressiveness of the lesion. Relatively high levels of expression of both mRNA species were seen in fibroblasts close to invasive tumor nests and, although only focally, in certain areas close to preinvasive tumors. These foci may represent hot spots for local degradation and invasive progression. Collectively, these results implicate MT1-MMP in collagen-stimulated MMP-2 activation and suggest that this mechanism may be employed in vivo by both tumor-associated fibroblasts and EMT-derived carcinoma cells to facilitate increased invasion and/or metastasis. [less ▲]

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See detailLe rôle de l'expert
Boxho, Philippe ULg

in Société d'étude du dommage corporel (1997)

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See detailIn vivo study of enhancing factors for guided bone formation
Biewer, Bob; Van Heusden, Alain ULg; Rompen, Eric ULg

in Journal of Clinical Periodontology (1997), 11

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See detailLa maladie de Buerger: aspects cliniques et pronostiques
VAN DAMME, Hendrik ULg; Deprez, E.; DEFRAIGNE, Jean ULg et al

in Revue Médicale de Liège (1997), 52(10), 675-82

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See detailUne route mérovingienne en Hautes-Fagnes (La Via Mansuerisca ?). Derniers résultats scientifiques.
Streel, Maurice ULg

in Bulletin de l"Académie Royale de Belgique, Classe Sciences 6e série (1997), VIII(7-12), 367-376

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See detailProduction and activation of matrix metalloprotease-9 (MMP-9) by HL-60 promyelocytic leukemia cells
Devy, L.; Noël, Agnès ULg; Baramova, E. et al

in Biochemical and Biophysical Research Communications (1997), 238

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of ... [more ▼]

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of extracellular matrix components. As shown by gelatin zymography, HL-60 cells constitutively released significant amounts of proMMP-9 (92 kDa) and moderate amounts of proMMP-2 (72 kDa). Furthermore, casein zymography confirmed the presence of serine proteases in the form of pro-urokinase. Activation of proMMP-9 was dependent on the plasminogen activator/plasmin (PA/plasmin) system and was inhibited by aprotinin. MMP-9 was only detected in cellular extracts or conditioned media incubated with HL-60 cells, indicating that cells are essential to the activation process. Addition of plasminogen increased by 3-fold the basal invasive rate of these cells across a matrigel layer (2.1%versus0.7% in control cells after 4 h of incubation). Taken together, these results indicate that HL-60 cells exhibit an autocrine activation mechanism of proMMP-9 via the PA/plasmin system and that activation of proMMP-9 increases their invasive potential [less ▲]

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See detailReactivite bronchique chez les patients diabetiques.
Piéron, Maurice ULg; Scheen, André ULg; Corhay, Jean-Louis ULg et al

in Revue des Maladies Respiratoires (1997), 14(5), 379-85

The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on ... [more ▼]

The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on the ventilatory parameters measured during a methacholine-induced bronchoconstriction test. Ten insulin-dependent diabetic patients without CAN, ten insulin-dependent diabetic patients with CAN and ten healthy volunteers, all non-smokers and free of respiratory symptoms, have undergone a functional respiratory check-up before the methacholine test. The presence of CAN was classically studied by the decrease in heart rate changes during three standardized tests (deep breathing at 6 cycles/min, Valsalva manoeuver, orthostatism) which all mainly explore the parasympathetic function. The bronchial response to methacholine was similar in the healthy subjects and in the diabetic patients without CAN. However, the fall in forced expiratory volume in 1 second induced by the highest dose of methacholine was significantly less marked in the diabetic subjects with CAN than in the two other groups. These results suggest that the diabetic autonomic neuropathy also involves the vagal innervation of the respiratory tract. [less ▲]

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See detailThe He(I), Threshold photoelectron and Constant Ion State spectroscopy of Vinylchloride (C2H3Cl).
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been ... [more ▼]

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been measured and reexamined. The threshold photoelectron spectrum has been measured between 9.0 and 25.0 eV and the photon energy range of 9.9-12.0 eV has been investigated in detail. Many features have been identified and tentatively assigned with the help of the photoabsorption spectroscopic results. These data were compared with the well-resolved He(I) photoelectron spectrum. The fine structure observed in the two first ionic states is assigned to progressions belonging partially to previously unobserved vibration normal modes. State-selected CIS spectra have been recorded for the first vibronic states between 10.0 and 11.67 eV. They exhibit fine structure assigned to autoionization of Rydberg states. [less ▲]

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See detailEtude morphométrique du sabot et du petit sésamoïde du cheval
Gabriel, Annick ULg; Detilleux, J.; Jolly, S. et al

in Annales de Médecine Vétérinaire (1997), 147

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See detailL'artiste belge entre le mot et l'image (quelques éléments de comparaison entre Hergé, Michaux, Magritte)
Defays, Jean-Marc ULg

in Texte : Revue de Critique et de Théorie Littéraire (1997), 21-22

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See detailExpression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines.
Gilles, Christine ULg; Polette, M.; Birembaut, P. et al

in Clinical & Experimental Metastasis (1997), 15(5), 519-26

We have previously observed in vitro that some stromal proteinases (MMP-2, MT1-MMP) were expressed or activated by invasive carcinoma cell lines exhibiting mesenchymal features, presumably acquired ... [more ▼]

We have previously observed in vitro that some stromal proteinases (MMP-2, MT1-MMP) were expressed or activated by invasive carcinoma cell lines exhibiting mesenchymal features, presumably acquired through an epithelial to mesenchymal transition (EMT). To examine the potential contribution of c-ets-1 to this phenotype, we have compared here the expression of c-ets-1 with invasiveness in vitro and expression of vimentin, E-cadherin, uPA, MMP-1 and MMP-3 in a panel of human breast cancer cell lines. Our results clearly demonstrate an association between c-ets-1 expression and the invasive, EMT-derived phenotype, which is typified by the expression of vimentin and the lack of E-cadherin. While absent from the two non-invasive, vimentin-negative cell lines, c-ets-1 was abundantly expressed in all the four vimentin-positive lines. However, we could not find a clear quantitative or qualitative relationship between the expression of c-ets-1 and the three proteinases known to be regulated by c-ets-1, except that when they were expressed, it was only in the invasive c-ets-1-positive lines. UPA mRNAs were found in three of the four vimentin-positive lines, MMP-1 in two of the four, and MMP-3 could not be detected in any of the cell lines. Intriguingly, MDA-MB-435 cells, which exhibit the highest metastatic potential of these cell lines in nude mice, expressed vimentin and c-ets-1, but lacked expression of these three proteinases, at least under the culture conditions employed. Taken together, our results show that c-ets-1 expression is associated with an invasive, EMT-derived phenotype in breast cancer cells, although it is apparently not sufficient to ensure the expression of uPA, MMP-1 or MMP-3, in the vimentin-positive cells. Such proteases regulation is undoubtedly qualified by the cellular context. This study therefore advances our understanding of the molecular regulation of invasiveness in EMT-associated carcinoma progression, and suggests that c-ets-1 may contribute to the invasive phenotype in carcinoma cells. [less ▲]

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See detailIntratumoral heterogeneity for hsp90 mRNA levels in a breast cancer cell line
Luparello, C.; Noël, Agnès ULg; Pucci-Minafra, I.

in DNA & Cell Biology (1997), 16

BC-3A and BC-61 are two breast cancer cell lines that have been cloned from parental 8701-BC cells and exhibit different biosynthetic, proliferative, and invasive properties in vitro. In the attempt to ... [more ▼]

BC-3A and BC-61 are two breast cancer cell lines that have been cloned from parental 8701-BC cells and exhibit different biosynthetic, proliferative, and invasive properties in vitro. In the attempt to search whether alterations in the profiles of gene expression could be detected, we have submitted both cytotypes to identification of differentially expressed cDNAs. In addition, steroid hormone receptor mRNA arrays and in vivo tumorigenesis of the two lines have been checked. The technique used allowed identification of changes in the expression of the 90-kD heat shock protein-beta (hsp90beta) which is prominently down-regulated in BC-61 cells. Because we have also found that these cells, which lack estrogen receptor mRNA synthesis, display a more invasive behavior in vitro and increased tumorigenesis in vivo, we propose that evaluation of hsp903 transcript levels may be taken into consideration for screening as a novel molecular marker of breast cancer progression. [less ▲]

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See detailAn introduction to ET-LOTOS for the description of time-sensitive systems
Léonard, Luc; Leduc, Guy ULg

in Computer Networks & ISDN Systems (1997), 29(3), 271-292

Enhanced Timed-LOTOS, called ET-LOTOS, is an extension of LOTOS allowing the modelling of time-sensitive systems (i.e. systems whose behaviour is influenced by the passing of time). It is the basis of the ... [more ▼]

Enhanced Timed-LOTOS, called ET-LOTOS, is an extension of LOTOS allowing the modelling of time-sensitive systems (i.e. systems whose behaviour is influenced by the passing of time). It is the basis of the timed extension of LOTOS currently developed by ISO (1995). The purpose of this paper is to present ET-LOTOS in a tutorial style and show its applicability. The detailed study of the formal semantics is addressed in another paper. A collection of small but realistic, examples illustrates a wide variety of time-sensitive protocol mechanisms. These examples are used to introduce and justify the extensions of our language. Finally, the basics of the formal semantics are given and a comparison is made with other timed formalisms. [less ▲]

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See detailLa cavernostomie: une ancienne technique parfois efficace dans le traitement des abcès pulmonaires
Defraigne, Jean-Olivier ULg; Siquet, J.; Limet, Raymond ULg

in Revue Médicale de Liège (1997), 52(7), 498-501

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See detailGenetic Diversity In Lima Bean (Phaseolus Lunatus L) As Revealed By Rapd Markers
Fofana, B.; Vekemans, X.; Du Jardin, Patrick ULg et al

in Euphytica (1997), 95(2),

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See detailApprentissage implicite et temps de réaction sériel: Une perspective développementale
Meulemans, Thierry ULg; Van der Linden, Martial ULg; Perruchet, Pierre

in Neuropsychiatrie de l'Enfance et de l'Adolescence (1997), 45(7-8), 384-386

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See detailHuman TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer
Jacquemin, Patrick; Martial, Joseph ULg; Davidson, Irwin

in Journal of Biological Chemistry (1997), 272(20), 12928-37

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in ... [more ▼]

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in skeletal and cardiac muscle, but the strongest expression is observed in the placenta and in placenta-derived JEG-3 choriocarcinoma cells. In correlation with its placental expression, we show that hTEF-5 binds to several functional enhansons of the human chorionic somatomammotropin (hCS)-B gene enhancer. We define a novel functional element in this enhancer comprising tandemly repeated sites to which hTEF-5 binds cooperatively. In the corresponding region of the hCS-A enhancer, which is known to be inactive, this element is inactivated by a naturally occurring single base mutation that disrupts hTEF-5 binding. We further show that the binding of the previously described placental protein f/chorionic somatomammotropin enhancer factor-1 to TEF-binding sites is disrupted by monoclonal antibodies directed against the TEA domain and that this factor is a proteolytic degradation product of the TEF factors. These results strongly suggest that hTEF-5 regulates the activity of the hCS-B gene enhancer. [less ▲]

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See detailNeurophysines et cancer pulmonaire a petites cellules
Pirard, Françoise; Pequeux, Christel ULg; Hendrick, J. C. et al

in Revue Médicale de Liège (1997), 52(1), 22-6

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See detailPlaidoyer pour une expertise entièrement contradictoire en matière pénale
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailRecherches karstologiques au Sud Cameroun
Willems, Luc ULg

in Regards (1997), 28

Several karsts have been studied in South Cameroon, booth in gneiss and granite lithologies.

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See detailFibres alimentaires chez le chien II. Effets sur la vidange gastrique et le transit gastro-intestinal
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is ... [more ▼]

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is also given. The incorporation of fibres in the diet is one of many other factors which influence the mechanisms of emptying in the gastrointestinal tract. The effect of dietary fibres is also discussed in other monogastric species [less ▲]

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See detailEstimation of (co)variance components for Jersey type traits using a repeatability model
Gengler, Nicolas ULg; Wiggans, G. R.; Wright, J. R. et al

in Journal of Dairy Science (1997), 80(8), 1801-1806

(Co)variance components for final score and 15 linear type traits of Jersey cows were estimated by multitrait REML using multiple diagonalization and a repeatability model with 34,999 records of 22,354 ... [more ▼]

(Co)variance components for final score and 15 linear type traits of Jersey cows were estimated by multitrait REML using multiple diagonalization and a repeatability model with 34,999 records of 22,354 cows. Multiple diagonalization gave relative off-diagonals (ratio of squared off-diagonals to the product of diagonals) of <0.1%. Heritabilities and repeatabilities, respectively, were estimated as 0.29 and 0.48 for final score, 0.40 and 0.57 for stature, 0.26 and 0.39 for strength, 0.28 and 0.43 for dairy form, 0.13 and 0.25 for foot angle, 0.13 and 0.25 for rear legs (side view), 0.27 and 0.41 for body depth, 0.31 and 0.52 for rump angle, 0.22 and 0.33 for thurl width, 0.22 and 0.36 for fore udder attachment, 0.28 and 0.46 for rear udder height, 0.26 and 0.42 for rear udder width, 0.32 and 0.48 for udder depth, 0.20 and 0.36 for udder cleft, 0.29 and 0.46 for front teat placement, and 0.31 and 0.48 for teat length. Estimates of heritability generally were higher, and estimates of repeatability were lower, than values used previously for USDA genetic evaluations, which were based on data from the 1970s and early 1980s. Final score was highly correlated both genetically and phenotypically with dairy form and rear udder traits. These estimates of heritabilities and (co)variance components are necessary for multitrait genetic evaluation of linear type traits of US Jerseys. [less ▲]

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See detailGlobal adaptive stabilization of cascade nonlinear systems
Jankovic, M.; Sepulchre, Rodolphe ULg; Kokotovic, Petar V.

in Automatica (1997), 33(2), 263-368

An adaptive controller is developed for a class of nonlinear systems for which other approaches (e.g. backstepping) may fail to be applicable. The new design employs feedback passivation and an explicit ... [more ▼]

An adaptive controller is developed for a class of nonlinear systems for which other approaches (e.g. backstepping) may fail to be applicable. The new design employs feedback passivation and an explicit construction of a Lyapunov function for the zero dynamics with respect to a relative degree 1 output. As an illustration a longstanding "nonlinear benchmark problem" is solved. [less ▲]

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See detailApplication of canonical transformation with missing values to multitrait evaluation of Jersey type
Gengler, Nicolas ULg; Wiggans, G. R.; Wright, J. R. et al

in Journal of Dairy Science (1997), 80(10), 2563-2571

A multitrait animal model was used to calculate predicted transmitting ability and reliabilities for final score and 15 linear type traits of 225,632 US Jersey cows. Records were adjusted for age and ... [more ▼]

A multitrait animal model was used to calculate predicted transmitting ability and reliabilities for final score and 15 linear type traits of 225,632 US Jersey cows. Records were adjusted for age and stage of lactation before analysis. The model contained effects for interactions of herd and date scored; year scored, parity, and age; and herd and sire; effects of permanent environment and additive genetics were also included. Of the 381,511 records included, some observations were missing for final score (8%), body depth (43%), and teat length (33%). The evaluation system used a canonical transformation, included several random effects, and estimated missing values with each iteration. Inbreeding was considered in the computations. Convergence was achieved in approximately 50 rounds of iteration. Correlations between animal and sire model predicted transmitting ability ranged from 0.56 to 0.95 and generally were higher for bulls than for cows and for more recent birth years. Genetic trend was strongly positive for dairy form, final score, and rear udder traits (height and width) and negative for udder depth. For other traits, genetic trend was small. This methodology should improve the accuracy of genetic evaluations for type traits of US Jerseys. [less ▲]

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See detailmorbidity in neonates afetr labour induction or cesarean section
Battisti, Oreste ULg; Bertrand, J. M.; Adant-François, A. et al

in vlaamse verenigong voor obstetrie en gynaecologie jaarboek (1997), 1

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See detailLe traitement corticoïde dans les poussées de la maladie de Crohn de l'adulte
Belaiche, Jacques ULg; Louis, Edouard ULg

in Médecine et Hygiène (1997), 55

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See detailThe Nucleotide Sequence Of Saccharomyces Cerevisiae Chromosome Vii
Tettelin, H.; Carbone, Mla.; Albermann, K. et al

in Nature (1997), 387(6632),

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See detailUne maison médiévale à Dinant
Hoffsummer, Patrick ULg

in Annales de la Société Archéologique de Namur (1997), 71

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See detailIn vivo and in vitro development of preantral follicles
Van den Hurk, R.; Bevers, M. M.; Beckers, Jean-François ULg

in Theriogenology (1997), 47(1), 73-82

The paper presents the state of the art concerning the in vitro growth and differentiation of preantral follicles, i.e. from the primordial to the antral stage, in mammals. Attention is paid to their ... [more ▼]

The paper presents the state of the art concerning the in vitro growth and differentiation of preantral follicles, i.e. from the primordial to the antral stage, in mammals. Attention is paid to their normal structure and development, nomenclature, isolation and culture methods, effects of systemic and local compounds on their development, and viability of isolated and cultured follicules, with special reference to the bovine. In vivo, various endocrine and locally produced compounds stimulate neovascularization or innervation of small follicles, which provide nutrients, cytokines, hormones and neuropeptidergic substances, necessary of survival of follicles and initiation of follicle growth. In vitro, FSH, activin, EGF, TGFs and IVP seem important for survival and growth of cultured preantral follicles. However, many reported in vitro effects of hormonal compounds on preantral follicles, especially on those from the bovine, have to be interpreted carefully, since these studies presented little information on oocyte quality. In contrast to preantral follicles from small laboratory animals, pigs and humans, those from cows will not soon be usable for IVP, since their oocyte is relatively small and their growth rate relatively slow. Although practical application of especially small preantral for IVP of live-stock species still is far away, it should not be considered an utopia. [less ▲]

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See detailExpérimentation médicale sur l'être humain. Propositions pour un cadre législatif.
Palermini, Patricia ULg; Delfosse, Marie-Luce

in Revue de Droit de la Santé = Tijdschrift voor Gezondheidsrecht (1997), (5), 333-344

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See detailProtéinas placentárias em mamíferos
Melo de Sousa, Noelita; de Figueiredo, José Ricardo; Gonçalves, Paulo Bayard Dias et al

in Ciência Animal (1997), 7(1), 43-55

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins ... [more ▼]

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins, placental lactogens, interferon tau, pregnancy specific and pregnancy-associated glycoproteins. In spite of the importance of these studies, there are few papers that describe fundamental aspects of these placental proteins such as physical-chemical pregnancy diagnosis methods. Thus, the aim of this report is to present an overview on the major aspects of placental proteins studied up to now, as well as to consider perspectives for their applications in the future in veterinary practice. [less ▲]

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See detailBovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro
Hulshof, S. C. J.; Figueiredo, J. R.; Beckers, Jean-François ULg et al

in Theriogenology (1997), 48

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral ... [more ▼]

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantal follicles. In addition, activin immunoreactivity was observed in the theca of secondary follicles. In addition, activin preantral follicles, activin increased follicular growth and granulosa cell proliferation in a dose-dependent manner. This increase was further stimulated by addition of FSH. In conclusion, activin and its receptor are present on bovine follicles, and additional activin stimulates development of those follicles. [less ▲]

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See detailAerosol therapy in the equine species
Duvivier, Dominique Hannia; Votion, Dominique ULg; Vandenput, Sandrina ULg et al

in Veterinary Journal (1997), 154(3), 189-202

Inhalation therapy plays an increasing role in the management of equine respiratory disorders. This alternative to systematic treatment permits a high concentration of medication to act locally while ... [more ▼]

Inhalation therapy plays an increasing role in the management of equine respiratory disorders. This alternative to systematic treatment permits a high concentration of medication to act locally while minimizing side effects and residues. In human medicine, literature in this field is prolific and continuously renewed, whereas in veterinary medicine, applications of aerosol therapy are less extensive. This review considers the principles of action of the different types of devices used for inhalation, i.e., nebulization, metered-dose inhalation and dry powder inhalation, describes the technical and practical requirements for their use in the equine species and considers the advantages and disadvantages of each inhalation device. The pharmacological agents currently administered to horses by inhalation are also discussed. Perspectives of aerosol therapy in the equine species, including aerosols already used in human medicine and their potential applications for horses are described [less ▲]

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See detailBovine herpesvirus type 4. In Lymphotropicherpesviruses: Epstein-Barr virus and Human herpesvirus 8
Thiry, Etienne ULg; Lomonte, P.; Vanderplasschen, Alain ULg et al

in International Agency for research on cancer (1997)

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See detailUse of recombinant human erythropoietin after allogeneic bone marrow transplantation
Hermanne, J.-P.; Beguin, Yves ULg

in Erythropoiesis (1997), 8

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See detailConcordanze del «Canto novo» di Gabriele d’Annunzio.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailEtablissement d'un plan volontaire de contrôle de la rhinotrachéite infectieuse bovine en région wallonne de Belgique
De Wergifosse, Bertrand; Lemaire, Mylène; Pastoret, Paul-Pierre ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailSaisie-arrêt et concours des créanciers: fin d'une controverse, note sous Cass. (1ère ch.), 11 avr. 1997
Georges, Frédéric ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailCompte rendu du Cahier de Linguistique française, n°14 : Lexique et pragmatique
Defays, Jean-Marc ULg

in Français Moderne (Le) (1997), (2), 239-244

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See detailCompte rendu de A. Krug, Heilkunst und Heilkult. Medizin in der Antike, 2e édition, München, 1993
Marganne, Marie-Hélène ULg

in Revue Belge de Philologie et d'Histoire (1997), 75(1), 213-214

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See detailIntoxications par le Temik® chez les animaux domestiques et sauvages : un problème alarmant en Wallonie
Delaunois, Annie; Lessire, Françoise ULg; Ansay, M. et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailChanges in the Western Boundary Undercurrent outflow since the Last Glacial Maximum, from smectite/illite ratios in deep Labrador Sea sediments
Fagel, Nathalie ULg; Hillaire-Marcel; Robert, Christian

in Paleoceanography (1997), 12(1), 79-96

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador ... [more ▼]

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador Rise) of the Western Boundary Undercurrent (WBUC) gyre. At the two sites, smectites transported from the eastern Iceland and Irminger basins by the WBUC are observed. Clay mineral changes are used as proxies for the paleointensity reconstruction of the WBUC. On the Greenland Rise, a clay mineral index (smectite/illite (S/I) ratio) is defined. A S/I ratio of similar to 1 characterized the Last Glacial Maximum. It increased after similar to 17 ka, and reached a maximum value of 4 during the early Holocene, The mineralogical changes are gradual and do not show any reversal during the Younger Dryas, This pattern, which is confirmed by first-order estimations of smectite and illite fluxes, suggests gradually increasing sedimentary fluxes and WBUC intensity since the Last Glacial Maximum, A peak in the velocity of the WBUC at similar to 9 ka, as recorded by clay assemblages, is consistent with other regional studies based on pollen, foraminifera, or grain-size measurements, A massive dilution of smectites by illite and chlorite (S/I approximate to 3) occurs at similar to 8.5 ka. It corresponds to a period of rapid sediment accumulation and reflects an intensified illite-rich detrital supply by meltwaters from the southern Greenland Ice Margin. On the Labrador Rise, the smectite content varies between 20 and 60% with no obvious trend through time. The mineralogical composition is strongly influenced by ice-rafted deposition and by the abundance of fast deposit units (cf, Heinrich layers in the North Atlantic) which contain abundant detrital carbonates spilled-over from the North-West Atlantic Mid-Ocean Channel. In such layers, smectites are present but are diluted by the addition of illites, chlorites, and kaolinites. This provides evidence for a discrete and continuous WBUC supply of fine particles from the Irminger and Iceland Basins as far as the southeastern part of the Labrador Basin, Early deglacial smectite-rich layers (up to 60%) are also observed at this site, They indicate an increase in the outflow of the WBUC at similar to 13.5 ka, (Bolling-Allerod), as previously reported from grain size or foraminiferal assemblage studies. [less ▲]

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See detailCombined Ring Inversion and Side Group Rotation in Geminal Diphosphoryl Substituted Pyrrolinoxyl Radicals: ESR Analysis of Chemical Exchange between Four Nonequivalent Sites
Rockenbauer, Antal; Mercier, Anne; Le Moigne, François et al

in Journal of Physical Chemistry A (1997), 101(43), 7965-7970

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found ... [more ▼]

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found, for the 2,2-disubstituted compounds 2 and 3, dramatic changes in the spectra were observed as a function of the temperature. These changes were explained by a four-site chemical exchange model including both ring inversion and hindered rotation around the carbon-phosphorus bonds. For radical 3, the presence of additional 5,5-dimethyl substitution can completely block rotations around carbon-phosphorus bonds for certain ring geometries, while for other ring conformations chemical exchange still occurs through combined inversionrotation processes. An effective two-site model composed of nonequivalent sites and a superposition model composed of a pair of exchanging conformers and a pair of nonexchanging conformers were used to simulate spectrum variations. A satisfactory fit was obtained over the entire temperature range investigated. From the temperature dependence of the exchange frequencies the potential barriers for ring inversion (27 kJ/mol), for combined inversion-rotation (11 kJ/mol), and for rotation around the carbon-phosphorus bonds (14 kJ/mol) were estimated. [less ▲]

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See detailSoil oribatid mite communities (Acari: Oribatida) from high Shaba (Zaïre) in relation to vegetation
Noti, M.-I.; André, H. M.; Dufrêne, Marc ULg

in Applied Soil Ecology (1997), 5(1), 81-96

Soil oribatid mite communities from three vegetation types (forest, woodland and savanna) are described in Luiswishi (high Shaba, Zaïre) and 151 species were recorded. Oribatid communities are organized ... [more ▼]

Soil oribatid mite communities from three vegetation types (forest, woodland and savanna) are described in Luiswishi (high Shaba, Zaïre) and 151 species were recorded. Oribatid communities are organized along a successional gradient which parallels the regressive sere defined by phytosociologists and going from the dense forest ("muhulu"), the local climax, to the savanna, passing through the woodland ("miombo"). Within this gradient, oribatid communities may vary depending on the habitat (presence of grass, high termitaria). The impact of seasons (dry vs. rainy season) is weak in the forest but drastic in savanna. The various soil oribatid communities are related to man's activities since the regressive sere results from repeated burnings and associated agricultural practices. [less ▲]

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See detailFontes Graeci Sami, I. Η Σάμος στις πηγές από τον 8ο ως τον 6ο αι.
Vanhaegendoren, Koen ULg; Karla, Grammatiki

in Samiakes Meletēs (1997), 3

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See detailCharacterization of non pigmented B16 melanoma cell-derived cytotoxic factors.
Siwek, B.; De Pauw-Gillet, Marie-Claire ULg; Quetin-Leclercq, J. et al

in Chemico-Biological Interactions (1997), 103(1), 59-73

We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests ... [more ▼]

We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests used showed that ultrafiltrated conditioned media (CM U1 fraction) contained several cytotoxic factors with a Mw lower than 1000 Da. These factors seemed to act either directly or indirectly on cell membranes, mitochondria, on the cell cycle and on protein and DNA synthesis. A cytotoxic activity could be found even after high dilution of CM U1. These cytotoxic factors were rapidly released by B16 cells in culture, independently of cell confluence. Their activities in the treated cells were also very fast and the cytotoxic effects were irreversible after only a few hours of treatment. These factors were not intermediate products during melanogenesis, neither polyamines, nor proteases. At least one of them seemed to be a small acidic and basic stable peptide without disulfide bounds but not heat stable. The synthesis of at least one of these cytotoxic factors was inhibited by cycloheximide and the cytotoxic activity was partially destroyed by pronase and trypsin, but not by pepsin. The cytotoxicity was not modified by copper complexants or free radical inhibitors (bovine serum albumin (BSA), tyrosine, superoxyde dismutase (SOD), catalase, vitamin E). Furthermore the levels of glutathione peroxydase activity and reduced glutathione did not change after treatment by CM U1 as compared to controls. [less ▲]

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See detailTransition probabilities for forbidden lines in Cr II
Quinet, Pascal ULg

in Physica Scripta (1997), 55

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See detailNo-carrier-added asymmetric synthesis of alpha-methyl-alpha-amino acids labelled with fluorine-18
Damhaut, Philippe; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Tetrahedron (1997), 53(16), 5785-5796

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential ... [more ▼]

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential inhibitors of enzymatic functions, were regiospecifically labelled by nucleophilic substitution on trimethylammoniumbenzaldehyde triflate precursors 9. The [18F]fluoro aromatic aldehydes 12 obtained were easily converted to the corresponding [18F]fluorobenzyl halides [13 (X = 1)]. After alkylation of the lithium enolate of (2S,5S)-l-tert-Boc-2-tert-butyl-3,5-dimethyl-imidazolidin-4-one 2, the adducts were cleaved to give, after HPLC purification, various [18F]fluoro-α-methyl amino acid analogs with radiochemical yields of 10% (End of Bombardment, EOB) after a synthesis time of 120 min. The corresponding [19F]fluorinated amino acids 4 and [19F]fluoro intermediates were also prepared. [less ▲]

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See detailLa problématique de la matière grasse : aspects théoriques
Thonart, Philippe ULg; Destain, Jacqueline ULg; Antoine, P. et al

in Tribune de l'Eau (La) (1997), 586/2

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See detailExamen échographique de l'articulation métacarpo-phalangienne. Corrélation signes échographiques - lésions
Denoix, Jean-Marie; Thill, Emanuelle; Houliez, Didier et al

in Pratique Vétérinaire Equine (1997), 29

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and ... [more ▼]

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and sensitivity and specificity of the technique have been calculated. [less ▲]

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See detailManifestations indésirables des antidépresseurs
Charlier, Corinne ULg; Ansseau, Marc ULg; Pinto, Emmanuel ULg et al

in Toxicorama (1997), (Spécial LYON), 310-314

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See detailTerm analysis and Hyperfine Structure in Neutral Vanadium
Palmeri, P.; Biémont, Emile ULg; Quinet, P. et al

in Physica Scripta (1997), 55

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See detailGenetics and Inflammatory Bowel Disease: From Association Studies to Wide Genome Screen
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1997), 60(3, Jul-Sep), 201-3

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See detail67-kD laminin receptor expression correlates with worse prognostic indicators in non-small cell lung carcinomas.
Fontanini, G.; Vignati, S.; Chine, S. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1997), 3(2), 227-31

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67 ... [more ▼]

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67-kDa laminin receptor. Sixty-one of 72 patients (84.7%) displayed a MLuC5-positive reaction, which was usually localized in both the inner surface of the plasmatic membranes and the cytoplasm of neoplastic cells. When we compared the laminin receptor expression with clinicopathological and biological parameters such as histotype, grading, T status, N status, ploidy, proliferative activity, vessel invasion, and p53 protein accumulation, the following results were observed: (a) the mean expression of the receptor was higher in the group of patients with metastatic nodal involvement than in those with uninvolved lymph nodes (P = 0.02); (b) a high Ki-67 score (>13% of positive cells) was observed in tumors with a higher mean value of laminin receptor (P = 0.004); (c) the tumors harboring neoplastic emboli in their vessels showed a higher laminin receptor immunoreactivity (P = 0.02); and (d) a borderline association was found between the high mean value of laminin receptor immunopositivity and p53 accumulation in neoplastic cell nuclei (P = 0.05). Our observations indicate that detection of high tissue levels of 67-kDa laminin receptor is associated with an invasive phenotype in non-small cell lung cancer and may provide further information in the biological characterization of this type of cancer. [less ▲]

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See detailLe visage de l'Autre ou la conscience du regard
Mélon, Marc-Emmanuel ULg

in Revue belge du cinéma (1997), 41

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See detailProgramme EsQUIsE. Acquisition et interprétation de croquis d'architecture
Leclercq, Pierre ULg

in La lettre de l'IA (1997), 123

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See detailIn vivo binding of [F-18]altanserin to rat brain 5HT(2) receptors: A film and electronic autoradiographic study
Biver, Françoise; Lotstra, Françoise; Monclus, M. et al

in Nuclear Medicine and Biology (1997), 24(4), 357-360

To further validate its use in positron emission tomography (PET), we studied the binding of [18F]altanserin, a specific 5HT2 radioligand, in the rat brain using in vivo autoradiography. Distribution of ... [more ▼]

To further validate its use in positron emission tomography (PET), we studied the binding of [18F]altanserin, a specific 5HT2 radioligand, in the rat brain using in vivo autoradiography. Distribution of [18F]altanserin binding was comparable to the in vitro mapping of 5HT2 receptors reported in the literature. Selective displacers were used to test the reversibility and the selectivity of this radioligand. Specific binding of [18F]altanserin in the rat frontal cortex was quantified by direct counting with an electronic imaging system and by quantification on digitalized autoradiograms. Close results of about 30 pmol/g were obtained with both methods. Our data confirmed that [18F]altanserin is a valid tracer for 5HT2 receptors binding studies. [less ▲]

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See detailRecommandations pour la prévention de l’infection tuberculeuse dans les institutions de soins
Gosset, Christiane ULg; Prignot, J.; Schandevyl, W. et al

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (1997), 24(1), 50-56

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See detailIndependent prognostic value of the 67-kd laminin receptor in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Menard, Sylvie et al

in Journal of the National Cancer Institute (1997), 89(16), 1224-7

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See detailColestasis asociada a ticlopidina
Diaz Fuenzalida, A.; VALDES SOCIN, Hernan Gonzalo ULg; Laudano, O. et al

in Gastroenterologia y Hepatologia (1997), 20(3), 128-30

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of ... [more ▼]

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of jaundice, choluria, and itching of one month of evolution. The patient had taken ticlopidine twice a day for 3 months up to one week prior to admission for peripheral arteriopathy. Biopsy was performed showing acinar cholestasis and portal inflammatory infiltrate compatible with cholestasis due to hypersensitivity. Ticlopidine was discontinued by the patient himself one week prior to admission. The drug was not readministered and the evolution of the clinical and biochemical parameters of cholestasis decreased. The patient was asymptomatic and laboratory data were normal 4 months later. [less ▲]

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See detailThe role of bisphosphonates in the treatment of osteoporosis
Reginster, Jean-Yves ULg; Halkin, V.; Gosset, Christiane ULg et al

in Drugs of Today (Barcelona, Spain : 1998) (1997), 33

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See detailObesity and nutrition. The Belgian Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Beckers, F. et al

in Obesity Research (1997)

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See detailPostoperative spirometry after laparoscopy for lower abdominal or upper abdominal surgical procedures.
Joris, Jean ULg; Kaba, Abdourahmane ULg; Lamy, Maurice ULg

in British Journal of Anaesthesia (1997), 79(4), 422-6

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation ... [more ▼]

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation) (n = 10 in each group) to determine if lower abdominal laparoscopy results in less postoperative pulmonary dysfunction than upper abdominal laparoscopy. Pulmonary testing was performed before operation, and 3 and 6 h after operation, on the first and second days after surgery. After operation, a significant reduction in forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow rate occurred after laparoscopic cholecystectomy at each time. There were no significant changes after minor gynaecologic laparoscopy, whereas laparoscopic gynaecological surgery resulted in minor pulmonary dysfunction on the day of surgery only. We conclude that postoperative pulmonary function was less impaired after gynaecological laparoscopy than after laparoscopic cholecystectomy. This study suggests that the site of surgery is an important determinant of lung dysfunction after laparoscopy. [less ▲]

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See detailIgneous charnockites and related rocks from the Bjerkreim-Sogndal layered intrusion (Southwest Norway): a jotunite (hypersthene monzodiorite)-derived A-type granitoid suite
Duchesne, Jean-Clair ULg; Wilmart, Edith

in Journal of Petrology (1997), 38(3), 337-369

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and ... [more ▼]

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and geochemistry (major and trace elements) of 8 main rock types (88 samples) are considered. The rocks form a suite of K2O-rich alkali-calcic granitoids of A-type, deriving from jotunitic magma. Two trends of inferred liquids are distinguished: the main liquid line of descent which passes from jotunites through 2-pyroxene quartz mangerites to amphibole charnockites, the second one which encompasses olivine-bearing quartz mangerites and charnockites and is rooted into mangeritic liquids. Comparison with the Tellnes rock series reveals that contamination by leucogranitic material has taken place simultaneously with fractional crystallization in both BKSK trends. Zr, Rb, Cs, and Th are particularly sensitive to assimilation and the higher water content in BKSK. Zircon and apatite have saturated at the liquidus of quartz mangerite around 900°C, close to the FMQ buffer. The two-pyroxene quartz mangerites cannot have been equilibrated with the mangerite cumulates on which they rest. A major influx of magma took place when mangeritic cumulates were being deposited. It mingled and partly mixed with the resident contaminated magma. [less ▲]

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See detailThe spectrum of 67-kD laminin receptor expression in breast carcinoma progression.
Viacava, P.; Naccarato, A. G.; Collecchi, P. et al

in Journal of Pathology (The) (1997), 182(1), 36-44

Laminin is a glycoprotein of the basement membrane (BM), involved in a variety of normal and pathological cellular events including tumour invasion and metastasis. Cells bind laminin through different ... [more ▼]

Laminin is a glycoprotein of the basement membrane (BM), involved in a variety of normal and pathological cellular events including tumour invasion and metastasis. Cells bind laminin through different types of receptor. The 67-kD laminin receptor (67LR) is a cell-surface protein which binds laminin with high affinity. 67LR expression has been shown to increase in neoplastic cells, compared with normal tissues, and 67LR seems to play an important role during the first steps of neoplastic progression. In this study, 67LR expression was analysed during the morphological phases of breast cancer progression from normal tissue to invasive carcinoma. A total of 506 formalin-fixed, paraffin-embedded normal breast structures and lesions were stained by immunohistochemistry usign the MLuC5 monoclonal antibody, which is specific for 67LR. The results show that in normal breast and in any kind of breast lesion, myoepithelial and endothelial cells express 67LR. While 67LR is not seen in the epithelium of normal breast, cysts, adenosis, and benign tumours, it is expressed in the epithelial cells of several hyperplasias and carcinomas in situ, both ductal and lobular, as well as in all invasive carcinomas. The 67LR-positive cell subpopulation expands from hyperplastic lesions to invasive carcinoma, suggesting that 67LR could be related to the induction and progression of breast cancer. [less ▲]

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See detailHarm avoidance dimension of the Tridimensional Personality Questionnaire and serotonin-1A activity in depressed patients.
Hansenne, Michel ULg; Pitchot, William ULg; Moreno, A. G. et al

in Biological Psychiatry (1997), 42(10), 959-61

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See detailDifferential expression of galectin 3 and galectin 1 in colorectal cancer progression.
Sanjuan, X.; Fernandez, P. L.; Castells, A. et al

in Gastroenterology (1997), 113(6), 1906-15

BACKGROUND & AIMS: Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and ... [more ▼]

BACKGROUND & AIMS: Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS: Galectin 3 expression was examined immunohistochemically in 39 samples of normal mucosae, 25 adenomas, 87 carcinomas, and 39 lymph node metastases. Galectin 1 was analyzed in 25 samples of mucosae, 15 adenomas, 25 carcinomas, and 11 metastases. Western blot analysis was also performed. RESULTS: All normal mucosae showed strong nuclear galectin 3 expression, which was down-regulated in the neoplastic progression, because only 60% of adenomas, 48% of carcinomas, and 44% of metastases were strongly positive (P < 0.0001). Cytoplasmic expression was down-regulated in adenomas (16%) but increased again in carcinomas (64%) (P < 0.0001). Galectin 1 expression was mainly detected in stromal cells and correlated with tumor progression from normal mucosae to adenomas and carcinomas (P < 0.0001). CONCLUSIONS: Galectin 3 expression is down-regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Galectin 1 in colorectal mucosa is predominantly a stromal product whose overexpression is associated with the neoplastic progression of colorectal cancer. [less ▲]

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See detailRheinische Wortgeographie. Karten des Rheinischen Wörterbuchs und ihre computative Auswertung. Teil II
Möller, Robert ULg

in Rheinische Vierteljahrsblätter (1997), 61

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See detailLes hermeneis dans le christianisme primitif. Aux sources du schisme byzantin
Rochette, Bruno ULg

in Byzantion : Revue Internationale des Etudes Byzantines (1997), 67

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See detailDeux POHLIA méconnus d'Alsace: P.lutescens (Limpr.) Lindb. et P. lescuriana (Sull.) Andrews
Vanderpoorten, Alain ULg

in Bulletin de la Société d'Histoire Naturelle de Colmar (1997), 63

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See detailDidactique du latin et observation statistique
Denooz, Joseph ULg

in Euphrosyne (1997)

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See detailComment j'explore ... un patient avec hypotension orthostatique.
Scheen, André ULg; De Fooz, Geoffroy; Marchand, Monique ULg

in Revue Médicale de Liège (1997), 52(2), 116-9

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See detailEvolution of coronary atherosclerosis in patients with mild coronary artery disease studied by serial quantitative coronary angiography at 2 and 4 years follow-up. The Multicenter Anti-Atheroma Study (MAAS) Investigators.
Vos, J.; de Feyter, P. J.; Kingma, J. H. et al

in European heart journal (1997), 18(7), 1081-9

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The ... [more ▼]

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The objective of this study was to describe the natural course of focal and diffuse coronary atherosclerosis over time. METHODS AND RESULTS: In 129 patients with mild coronary artery disease, but not on lipid-lowering medication, three coronary angiograms were made each 2 years apart. Nine hundred and sixty five angiographically diseased and non-diseased segments were analysed by quantitative coronary angiography. Mean lumen diameter and minimal lumen diameter were used as measures of diffuse and focal coronary atherosclerosis. Mean lumen diameter and minimum lumen diameter decreased by 0.02 and 0.03 mm per year. The rate of progression was similar in the angiographically non-diseased, as in the mildly and moderately diseased segments. Progression of diffuse coronary atherosclerosis was largest in severely stenosed lesions (percentage diameter stenosis > or = 50%) and in the right coronary artery with a loss of 0.19 mm and 0.16 mm in mean lumen diameter. Progression of focal disease was most prominent in new and mild lesions and the right coronary artery, with a decrease in minimum lumen diameter of 0.34 mm and 0.22 mm. In most subgroups, progression occurred gradually over time. On a per segment level, progression and the occurrence of new lesions occurred in 4.4% and 4.2%. Regression and disappearance of a lesions was found in 2.3% and 1.9%. On a per patient level, 36% were progressors, 12% had a mixed response, 36% were stable, and 16% were regressors. CONCLUSION: Diffuse and focal coronary atherosclerosis progressed at the same rate in the first and second 2 years in stenosed and non-stenosed segments. The rate of coronary atherosclerosis progression was small, but was higher for focal than for diffuse disease. A minority of lesions progressed and spontaneous regression was rare. [less ▲]

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See detailHepatocyte transplantation prolongs survival and prevent development of brain edema in pigs with ischemic liver failure
Arkadopoulos, N.; Chen, S.; Khalili, T. et al

in Surgical Forum (1997), 44

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See detailElectron partitioning between the two branching quinol-oxidizing pathways in Acanthamoeba castellanii mitochondria during steady-state state 3 respiration.
Jarmuszkiewicz, W.; Sluse-Goffart, C.; Hryniewiecka, L. et al

in Journal of Biological Chemistry (1997), 273(17), 10174-10180

Amoeba mitochondria possess a respiratory chain with two quinol-oxidizing pathways: the cytochrome pathway and the cyanide-resistant alternative oxidase pathway. The ADP/O method, based on the non ... [more ▼]

Amoeba mitochondria possess a respiratory chain with two quinol-oxidizing pathways: the cytochrome pathway and the cyanide-resistant alternative oxidase pathway. The ADP/O method, based on the non-phosphorylating property of alternative oxidase, was used to determine contributions of both pathways in overall state 3 respiration in the presence of GMP (an activator of the alternative oxidase in amoeba) and succinate as oxidizable substrate. This method involves pair measurements of ADP/O ratios plus and minus benzohydroxamate (an inhibitor of the alternative oxidase). The requirements of the method are listed and verified. When overall state 3 respiration was decreased by increasing concentrations of n-butyl malonate (a non-penetrating inhibitor of succinate uptake), the quinone reduction level declined. At the same time, the alternative pathway contribution decreased sharply and became negligible when quinone redox state was lower than 50%, whereas the cytochrome pathway contribution first increased and then passed through a maximum at a quinone redox state of 58% and sharply decreased at a lower level of quinone reduction. This study is the first attempt to examine the steady-state kinetics of the two quinol-oxidizing pathways when both are active and to describe electron partitioning between them when the steady-state rate of the quinone-reducing pathway is varied. [less ▲]

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See detailComplications hepatiques de la chimiotherapie. De la cytolyse banale a la maladie veino-occlusive du foie.
Baron, Frédéric ULg; Beguin, Yves ULg

in Revue Médicale de Liège (1997), 52(2), 93-7

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See detailBacterial Constituents .71. Absolute Configuration Of The Isopyoverdin Chromophore
Michalke, R.; Taraz, K.; Budzikiewicz, H. et al

in Zeitschrift Fur Naturforschung C-A Journal of Biosciences (1997), 52(7-8),

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See detailZastosowanie ultrasonografii w diagnostyce klinicznej ukladu rozrodczego u bydla
Gajewski, Z.; Hanzen, Christian ULg; Thun, R. et al

in Nowa Weterynaria (1997)

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See detailL’arsénopyrite du Massif de Stavelot, Belgique
Hatert, Frédéric ULg

in Bulletin de la Société Royale des Sciences de Liège (1997), 66

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See detailA Deletion in the Bovine Myostatin Gene Causes the Double-Muscled Phenotype in Cattle
Grobet, L.; Martin, L. J.; Poncelet, D. et al

in Nature Genetics (1997), 17(1), 71-74

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled ... [more ▼]

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-muscle hyperplasia-that is, an increase in the number of muscle fibers rather than in their individual diameter. Although the hereditary nature of the double-muscled condition was recognized early on, the precise mode of inheritance has remained controversial; monogenic (domainant and recessive), oligogenic and polygenic models have been proposed. In the Belgian Blue cattle breed (BBCB), segregation analysis performed both in experimental crosses and in the outbred population suggested an autosomal recessive inheritance. This was confirmed when the muscular hypertrophy (mh) locus was mapped 3.1 cM from microsatellite TGLA44 on the centromeric end of bovine chromosome 2 (ref. 5). We used a positional candidate approach to demonstrate that a mutation in bovine MSTN, which encodes myostatin, a member of the TGF beta superfamily, is responsible for the double-muscled phenotype. We report an 11-bp deletion in the coding sequence for the bioactive carboxy-terminal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle. [less ▲]

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See detailOrigine des produits animaux et empreinte génétique
Portetelle, Daniel ULg; Mortiaux, Frédéric; Burny, Arsène et al

in Agricontact (1997), 294

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See detailTell Amarna 1997
Tunca, Önhan ULg

in Chronique archéologique en Syrie 2 (1997)

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See detailComparison between different methods of measurement of momentum and sensible heat fluxes over canopies.
Aubinet, Marc ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(1),

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Gunaïkeia (1997), 2

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See detailMemory kernels and effective Hamiltonians from time dependent methods. I. Predissociation with a curve crossing
Desouter, Michèle ULg; Liévin, Jacques

in Journal of Chemical Physics (1997), 107

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See detailIntroduction
Delhalle, Nancy ULg

in Alternatives Théâtrales (1997), 55

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See detailRelations entre les conditions d'habitat et la pathologie en production de viande bovine
Nicks, Baudouin ULg

in Aspects de la conception des bâtiments pour les bovins à viande (1997)

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See detailDesodorisation des lisiers de porcs.
Thonart, Philippe ULg

in Agricontact (1997)

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See detailMoufang affine buildings have Moufang spherical buildings at infinity
Van Maldeghem, H.; Van Steen, Kristel ULg

in Glasgow Mathematical Journal (1997), 39(Part 3), 237-241

We show in a direct and elementary way that the spherical building at infinity of every rank 3 affine building which satisfies Tits' Moufang condition, is itself a Moufang building. This result is also ... [more ▼]

We show in a direct and elementary way that the spherical building at infinity of every rank 3 affine building which satisfies Tits' Moufang condition, is itself a Moufang building. This result is also true for higher rank affine buildings by Tits' classification [4]. [less ▲]

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See detailCompte rendu de L. Couloubaritsis, J.-J. Wunenburger, La couleur, Bruxelles, 1993 (Recueil, 4)
Marganne, Marie-Hélène ULg

in Archives Internationales d'Histoire des Sciences (1997), 47

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