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See detailDetection of Ground Movements on the Mt. Etna Volcano using the Global Positioning System
Bruyninx, Carine; Warnant, René ULg

in Acta Vulcanologica (1995), 7(1), 27-33

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See detailMémoire et imagerie mentale
Van der Linden, Martial ULg; Coyette, Françoise; Meulemans, Thierry ULg

in Questions de Logopédie (1995), 31

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See detailInhaled nitric oxide for hemodynamic support after postpneumectomy ARDS
Chiche, Jean-Daniel; Canivet, Jean-Luc ULg; Damas, Pierre ULg et al

in Intensive Care Medicine (1995), 21(8), 675-678

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See detailFormer par les stages
Jadoulle, Jean-Louis ULg

in Pédagogies. Cahiers du Laboratoire de Pédagogie Expérimentale de l'Université de Louvain (1995), X

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See detailOxygen transfert during Bacillus subtilis fermentation. Influence of lipopeptide production and an oxygen vector.
Hbid, Ch; Jacques, Ph.; Meurice, E. et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103(B44),

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See detailEffect of risedronate on collagen cross-links in postmenopausal osteoporosis
Zegels, Brigitte ULg; Balena, R; Eastell, R et al

in Journal of Bone and Mineral Research (1995), 10(s1), 455

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See detailFundamentals of transformed skeletal muscle used for cardiac assistance. An overview
Radermacker, M. A.; Chachques, J. C.; Sluse, Francis ULg et al

in Research in Surgery (1995), 7

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See detailPostgastroplasty recovery of ideal body weight normalizes glucose and insulin metabolism in obese women.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(2), 364-9

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months ... [more ▼]

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months after successful gastroplasty (BMI, 23.7 +/- 0.6 kg/m2) in eight obese women and, for comparison, in eight age- and weight-matched nonobese control women (BMI, 23.6 +/- 0.7 kg/m2). All subjects had normal oral glucose tolerance. The insulin secretion rate (ISR) was derived by deconvolution of plasma C-peptide levels and the insulin MCR (MCRI) by dividing the 0-180 min area under the curve (AUC) of ISR by that of plasma insulin levels (IRI). The insulin sensitivity index (SI) and the glucose effectiveness index (SG) were calculated using Bergman's minimal model. Before gastroplasty, obese subjects showed higher AUC-IRI (P < 0.001) and AUC-ISR (P < 0.02), lower MCRI (P < 0.005) and SI (P < 0.002), but similar SG values, compared to nonobese controls. After gastroplasty, the AUC-IRI dramatically decreased, due to both a reduction of AUC-ISR (from 58,252 +/- 8,437 to 36,675 +/- 4,274 pmol; P < 0.05) and an increase in MCRI (from 658 +/- 117 to 1,299 +/- 127 mL/min.m-2; P < 0.02). SI significantly rose from 4.74 +/- 0.74 to 9.15 +/- 0.96 10(-5) min-1/pmol.L (P < 0.01), whereas SG remained unchanged. All of these parameters became similar to those in nonobese controls (respectively, 32,522 +/- 3,458, 1,180 +/- 101, and 8.48 +/- 1.25; all P = NS). In conclusion, after gastroplasty-induced normalization of body weight, postobese women recover normal insulin secretion, clearance, and action on glucose metabolism. [less ▲]

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See detailDebate. Personal Experience and Research Experience : A Reflexive Account
Martiniello, Marco ULg; Ouali, Nouria; Choenni, C.

in Merger (1995), 3(2), 4-7

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See detailHIV-1 and NF-kappaB activation by photo-oxidative stress
Piette, Jacques ULg; Legrand-Poels, Sylvie ULg; Piret, Bernard

in Photochemistry & Photobiology (1995)

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See detailThe appearance energy of C2H+ from C2H2 revisited. A Photoion-Photoelectron Coincidence Spectroscopic Determination.
Servais, Christian ULg; Locht, Robert ULg

in Chemical Physics Letters (1995), 236

The dissociative ionization of C2H2 in the C2H+-producing channel has been reconsidered. The photoion-photoelectron coincidence (PIPECO) technique has been used. The C2H+/e coincidence rate has been ... [more ▼]

The dissociative ionization of C2H2 in the C2H+-producing channel has been reconsidered. The photoion-photoelectron coincidence (PIPECO) technique has been used. The C2H+/e coincidence rate has been recorded between 16.2 and 21.2 eV. The lowest appearance energy determined for C2H+ is 17.35+/-0.04 eV. A second appearance energy is measured at 18.40+/-0.04 eV. At both energies ethynyl ions are produced through a predissociation mechanism at the expense of the C2H2+(A2Ag) state at 17.35 eV and C2H2+(B2Sigma+/g) at 18.40 eV. These results are in good agreement with the most recent TPIPECO experiments and dissociative electroionization results. This comparison leads to the exclusion of any contribution of autoionization phenomena to the C2H+ ion production between 16.2 and 21.2 eV. Investigations of C2H+ through the ion-pair formation channel (and dissociative electron attachment producing C2H- and H-) in C2H2 are reported and its contribution to C2H+ ion production below 17.3 eV must be discarded. [less ▲]

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See detailRecent advances in ring-opening polymerization of lactones and related compounds
Lögfren, Anders; Albertsson, Ann-Christine; Dubois, Philippe ULg et al

in Journal of Macromolecular Science - Reviews in Macromolecular Chemistry and Physics (1995), C35(3), 379-418

Polyesters are currently synthesized by a step-growth mechanism from a mixture of a diol and a diacid (or a diacid derivative), or from a hydroxy-acid when available. Ring-opening polymerization (ROP) of ... [more ▼]

Polyesters are currently synthesized by a step-growth mechanism from a mixture of a diol and a diacid (or a diacid derivative), or from a hydroxy-acid when available. Ring-opening polymerization (ROP) of lactones and related compounds is an alternative method for the synthesis of aliphatic polyesters. Comparison of these two mechanisms is clearly in favor of the polyaddition process. The drawbacks of polycondensation are well known:high temperatures and long reaction times are required to produce high-molecular-weight chains. Even though conversion of the hydroxyl and acid group is close to completion, any departure from the reaction stoichiometry has a very detrimental effect on the chain length. [less ▲]

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See detailAn early origin of plastids within the cyanobacterial divergence is suggested by evolutionary trees based on complete 16S rRNA sequences
Nelissen, Bart; Van De Peer, Yves; Wilmotte, Annick ULg et al

in Molecular Biology and Evolution (1995), 12

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on ... [more ▼]

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on partial 16S rRNA sequences suggested a relatively late origin of plastids within the cyanobacterial divergence. In order to clarify the exact relationship and divergence order of cyanobacteria and plastids, we studied their phylogeny on the basis of nearly complete 16S rRNA gene sequences. The data set comprised 15 strains of cyanobacteria from different morphological groups, 1 prochlorophyte, and plastids belonging to 8 species of plants and 12 species of diverse algae. This set included three cyanobacterial sequences determined in this study. This is the most comprehensive set of complete cyanobacterial and plastidial 16S rRNA sequences used so far. Phylogenetic trees were constructed using neighbor joining and maximum parsimony, and the reliability of the tree topologies was tested by different methods. Our results suggest an early origin of plastids within the cyanobacterial divergence, preceded only by the divergence of two cyanobacterial genera, Gloeobacter and Pseudanabaena. [less ▲]

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See detailApplication of sucrose synthase from rice grains for the synthesis of carbohydrates.
Elling, Lothar; Grothus, Marita; Zervosen, Astrid ULg et al

in Annals of the New York Academy of Sciences (1995), 750

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are ... [more ▼]

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are required as substrates for glycosyltransferases. Activated sugars are usually synthesized by pyrophosphorylases from nucleoside triphosphates and sugar-l-phosphates.'.* For cyclic in situ regeneration, at least three enzymes are needed, which makes the synthesis of, for example, N-acetyllactosamine very complex by established procedure. We report here on the enzymatic synthesis of saccharides and activated sugars by the plant glycosyltransferase sucrose synthase (EC 2.4.1.13)! The glycosyltransferase has the unique feature of catalyzing in vitro the synthesis and cleavage of sucrose (SCHEME1 ). The main advantage of sucrose synthase over pyrophosphorylases is the utilization of nucleoside diphosphates (NDP) instead of nucleoside triphosphates to generate activated sugars. [less ▲]

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See detailDNA polymorphism detection in Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae): potential use in stored product pest management
Braet, Yves; Haubruge, Eric ULg

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1995), 6

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See detailA microscopic study of barium titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1995), 164

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See detailUterine vascularity during stimulation and its correlation with implantation in in-vitro fertilization.
Bassil, Salim; Magritte, Jean-Philippe; Roth, Jurgen et al

in Human Reproduction (1995), 10(6), 1497-1501

The changes in uterine artery blood flow in women undergoing in-vitro fertilization cycles were studied throughout stimulation after gonadotrophin-releasing hormone (GnRH) desensitization. The data ... [more ▼]

The changes in uterine artery blood flow in women undergoing in-vitro fertilization cycles were studied throughout stimulation after gonadotrophin-releasing hormone (GnRH) desensitization. The data obtained showed that the uterine vascularity was related to hormonal changes. The GnRH agonist effect was seen only after the third week of administration, and the uterine perfusion was significantly (P = 0.002) improved by the oestradiol secretion. Human chorionic gonadotrophins increased the resistance index (RI) significantly (P = 0.0001) for a period of 48 h. Then the progesterone secretion modified the curve with a significant improvement in the uterine blood flow (P = 0.03). Comparison of the RI value 2 days before human menopausal gonadotrophin (HMG) commencement, in patients with and without pregnancy, showed a higher RI in patients who did not conceive but no difference was observed on the day of embryo transfer. The pregnancy rates were similar whatever the range of the RI observed. The data available so far suggest that haemodynamic parameters alone, detected by Doppler sonography, do not provide full information on endometrial receptivity on the day of embryo transfer. A resistance index > 0.79 before HMG commencement seems to indicate poor uterine vascularity and may necessitate an increase in the HMG doses to prevent endometrial immaturity. [less ▲]

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See detailEfficacité des solutions envisagées par des enseignants en formation face à des problèmes rencontrés dans des leçons d’éducation physique
Beckers-Ledent, Maryse; Cloes, Marc ULg; Delfosse, Catherine et al

in Revue de l'Education Physique (1995), 35(4), 173-179

La recherche sur l'efficacité de l'enseignement s'est concrétisée et a trouvé application dans plusieurs ouvrages de didactique. Elle a été menée à partir de données directement observables, les ... [more ▼]

La recherche sur l'efficacité de l'enseignement s'est concrétisée et a trouvé application dans plusieurs ouvrages de didactique. Elle a été menée à partir de données directement observables, les comportements et stratégies d'enseignement dans l'action en classe. L'observation des comportements des enseignants, des élèves et des interactions entre ces différents acteurs a contribué à identifier des variables du processus en relation positive ou négative avec les progrès des élèves. ... [less ▲]

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See detailAnalyse critique de l'utilisation d'un appareil isocinétique
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Journal de Traumatologie du Sport (1995), 12

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See detailA biotechnological process to produce sulfide from the industrial by-product gypsum : new investigations
Hiligsmann, Serge ULg; Taillieu, Xavier; Thonart, Philippe ULg

in Med. Fac. Landbouww. Univ. Gent 60/4b (1995)

Different methods to isolate acetate-oxidizing sulfate-reducing bacteria (SRB) have been applied to samples containing relatively high concentrations of sulfate. However, the presence of facultative ... [more ▼]

Different methods to isolate acetate-oxidizing sulfate-reducing bacteria (SRB) have been applied to samples containing relatively high concentrations of sulfate. However, the presence of facultative anaerobic bacteria, identified as enterobacteriaceae, did not allow to obtain pure strains. Consequently, the influence of this contaminant in SRB cultures was investigated with particular attention being paid to the gases produced by the contaminant. [less ▲]

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See detailKarel Tchapek : humaniste et visionnaire
Mouton, Charles ULg

in Revue Générale (1995), (6/7), 71-80

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See detailDe ruimtebeleving in Vestdijks Verzamelde verhalen III
Nachtergaele, Lutgarde ULg

in Vestdijkkroniek (1995), 88-89

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See detailFracture de la hanche. Données épidémiologiques et approche thérapeutique
Reginster, Jean-Yves ULg

in Le Monde Médical de la Femme (1995), 8

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See detailTreatment of patent ductus arteriosus by placement of intravascular coils in a pup
Snaps, Frédéric ULg; Mc Entee, Kathleen ULg; Saunders, J. et al

in Journal of the American Veterinary Medical Association [=JAVMA] (1995), 6(6), 724-725

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a ... [more ▼]

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a large aortic base was outlined. A second selective angiographic procedure was performed to functionally close the PDA by use of thrombotic coils; complete obstruction was obtained. Twenty-four hours after the procedure, the murmur disappeared. One month later, the dog was reexamined and found to be clinically normal. [less ▲]

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See detailOpera Latina : la banque de données de textes latins du L.A.S.L.A. sur CD-ROM
Purnelle, Gérald ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1995)

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See detailIron chelation decreases NF-kappaB and HIV-1 activation due to oxidative stress
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in AIDS Research and Human Retroviruses (1995)

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See detailModulation of the Clozapine Structure Increases Its Selectivity for the Dopamine D4 Receptor
Liégeois, Jean-François ULg; Bruhwyler, J.; Damas, Jacques ULg et al

in European Journal of Pharmacology (1995), 273(3), 1-3

Clozapine has a more marked affinity for the recently cloned dopamine D4 receptor than for the dopamine D2 receptor. In the search for a selective ligand for the dopamine D4 receptor, useful as a ... [more ▼]

Clozapine has a more marked affinity for the recently cloned dopamine D4 receptor than for the dopamine D2 receptor. In the search for a selective ligand for the dopamine D4 receptor, useful as a pharmacological tool or as a potent atypical antipsychotic, a pyridobenzodiazepine derivative bioisoster of clozapine, JL 18, 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido [2,3-b][1,4]benzodiazepine, was found to be the most dopamine D4-selective ligand belonging to the diarylazepine class. Indeed, JL 18 binds to the dopamine D4 receptor with affinity up to 25 times superior to that for the dopamine D2 receptor and presents reduced affinities for other receptors. [less ▲]

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See detailPlasma Hormones and Metabolites in Cattle in Relation to Breed (Belgian Blue Vs Holstein) and Conformation (Double-Muscled Vs Dual-Purpose Type)
Clinquart, Antoine ULg; Van Eenaeme, Christian ULg; Mayombo, A. P. et al

in Veterinary Research Communications (1995), 19(3), 185-94

Four Belgian Blue double-muscled type (BBDM) bulls, four Belgian Blue dual-purpose type (BBDP) bulls and four Holstein bulls were used in a fattening trial in order to relate differences in the extent of ... [more ▼]

Four Belgian Blue double-muscled type (BBDM) bulls, four Belgian Blue dual-purpose type (BBDP) bulls and four Holstein bulls were used in a fattening trial in order to relate differences in the extent of muscle development and adiposity to differences in digestibility, endocrine status, protein and lipid metabolism. The larger muscle development in BBDM animals was associated with a trend to higher nitrogen retention, higher food conversion efficiency (p < 0.05) and lower apparent digestibility (p < 0.05). No difference was found between the groups for plasma glucose concentration. Higher creatinine, lower alpha-amino nitrogen, lower triglycerides and higher non-esterified fatty acid plasma levels were observed in BBDM as compared to Holstein bulls (p < 0.05), the BBDP group being intermediate. A trend to a higher cholesterol plasma level was found in BBDM animals. There was no difference between the three groups in plasma fatty acid composition, except for the C14:0 content. Some of the differences in plasma metabolites were related to carcass composition and endocrine regulation, a decrease in muscle development and an increase in adiposity being associated with lower growth hormone production (p < 0.05) and higher insulin (p < 0.05) and IGF secretions. The insulin/growth hormone ratio at the end of the fattening period was 0.0011, 0.0018 and 0.0069 in BBDM, BBDP and Holstein bulls, respectively, and was directly associated with fat deposition. [less ▲]

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See detailEtiologie et physiopathologie du diabète de type 2.
SCHEEN, André ULg; PAQUOT, Nicolas ULg; Lefevre, P.

in Problèmes Actuels d'Endocrinologie et de Nutrition (1995), 10

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See detailApport des données RSO de ERS1 dans l’étude bathymétrique et pour la cartographie des zones intertidales
Cornet, Yves ULg; Ozer, André ULg; Ferrari, M.

in Documents de travail du Centre National de Recherches Géomorphologiques (1995), 30

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See detailDe la necessite des services d'urgence de la main.
CARLIER, Alain ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1995), 150(7-9), 268-80280-2

Microsurgical techniques have been able to realize anastomoses of small vessels and nerves, with a high rate of success when performed by teams involved in that field. This has changed the concept of ... [more ▼]

Microsurgical techniques have been able to realize anastomoses of small vessels and nerves, with a high rate of success when performed by teams involved in that field. This has changed the concept of surgery of the hand. Reconstruction aims now at a functional result. Organisation of emergencies in hand surgery requires facilitations: hand surgeons, equipment and a team on a 24-hour basis, able to operate any kind of hand trauma. Since 1979, Liege is affiliated to the European Federation. Advantages of the immediate repair are significant repair are significant: reduction of the permanent disability rate, and in many instances, return to work at the same position. In conclusion, early treatment of the injuries of the hand is very effective, but need to be performed by specialists in the field of hand surgery. [less ▲]

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See detailInverse Modulation of Intraepithelial Langerhans' Cells and Stromal Macrophage/Dendrocyte Populations in Human Papillomavirus-Associated Squamous Intraepithelial Lesions of the Cervix
Al-Saleh, Walid; Delvenne, Philippe ULg; Arrese Estrada, Jorge ULg et al

in Virchows Archiv : An International Journal of Pathology (1995), 427(1), 41-8

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal ... [more ▼]

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal macrophages/dendrocytes by immunohistochemistry using anti-S100, -L1, -CD68 and -factor XIIIa antibodies. Human papillomavirus (HPV) detection was performed in all cases by using first a mixture of DNA probes for 14 HPV types commonly found in anogenital biopsies at low stringency conditions (Tm -40 degrees C) and by reanalyzing the tissues at high stringency (Tm -10 degrees C) with HPV 6/11, 16/18 and 31/33/35 biotinylated probe cocktails and individual digoxigenin-labelled probes. SILs and metaplastic tissues were significantly associated with a depletion of S100-positive intraepithelial Langerhans' cells when compared with normal epithelium. In contrast, there was a significant increase in L1-positive stromal macrophages in SIL biopsies compared with normal or metaplastic cervix. A significantly higher density of CD68-positive macrophages was also observed in high-grade SILs compared with normal or metaplastic biopsies and with low-grade SILs. The density of factor XIIIa-positive dendrocytes was found to be higher in SILs compared with metaplastic tissues and in high-grade SILs when compared with normal cervical biopsies. No specific relationship was found between the densities of these cells and the HPV type detected in SILs separated into low grade and high grade. The significance of this inverse modulation of intraepithelial Langerhans' cells and stromal macrophages/dendrocytes in normal and SIL biopsies is discussed in relation to HPV infection and malignant transformation. [less ▲]

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See detailLa classification fonctionnelle des dysfonctions de la valvule mitrale selon Carpentier
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 292-4

Pour aborder le traitement chirurgical de la valvule mitrale autrement, c'est-à-dire par une réparation valvulaire comme alternative raisonnable au remplacement sytématique, il faut recourir à une ... [more ▼]

Pour aborder le traitement chirurgical de la valvule mitrale autrement, c'est-à-dire par une réparation valvulaire comme alternative raisonnable au remplacement sytématique, il faut recourir à une classfication fonctionnelle des dysfonctions mitrales. Cette classification, établie par Carpentier (1, 2) regroupe les dysfonctions valvulaire mitrales en trois rubriques : a) le type caractérisé par des mouvements valvulaires normaux, b) le type 2, équivalent au prolapsus valvulaire, c) le type 3, correspondant à la restriction des mouvements valvulaires. Cette approche nouvelle postule, en outre, qu'une affection valvulaire n'est parfaitement définie que lorsqu'on en connaît l'étiologie, les lésions et les dysfonctions. L'utilisation de cette méthode analytique (qui a l'avantage de la simplicité et de la clarté) permet au chirurgien de réparer la valvule mitrale en adaptant à chaque dysfonction une correction appropriée et, par l'application de règles, d'obtenir des résultats reproductibles (3-6). [less ▲]

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See detailSixièmes Journées scientifiques de Télédétection : télédétection des espaces urbains et péri-urbains
Donnay, Jean-Paul ULg

in Lettre d'information du Réseau de Télédétection de l'UREF (1995), 28

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See detailLes Coléoptères Carabidae (Coleoptera) de la Réserve Naturelle du Pré des Forges à Mirwart
Waeyenbergh, M.; Dufrêne, Marc ULg; Lebrun, Philippe

in Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1995), 131

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See detailLa traduction de textes religieux dans l'Egypte gréco-romaine
Rochette, Bruno ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1995), 8

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See detailAvoided overlap between two resonance energies or frequencies. Formation of fast and slow decay modes
Desouter, Michèle ULg; Jacques, Vincent

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

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See detailSimulating The Folding Of Small Proteins By Use Of The Local Minimum Energy And The Free Solvation Energy Yields Native-Like Structures
Brasseur, Robert ULg

in Journal of Molecular Graphics (1995), 13(5), 312-22

Assuming that the protein primary sequence contains all information required to fold a protein into its native tertiary structure, we propose a new computational approach to protein folding by ... [more ▼]

Assuming that the protein primary sequence contains all information required to fold a protein into its native tertiary structure, we propose a new computational approach to protein folding by distributing the total energy of the macromolecular system along the torsional axes. We further derive a new semiempirical equation to calculate the total energy of a macromolecular system including its free energy of solvation. The energy of solvation makes an important contribution to the stability of biological structures. The segregation of hydrophilic and hydrophobic domains is essential for the formation of micelles, lipid bilayers, and biological membranes, and it is also important for protein folding. The free energy of solvation consists of two components: one derived from interactions between the atoms of the protein, and the second resulting from interactions between the protein and the solvent. The latter component is expressed as a function of the fractional area of protein atoms accessible to the solvent. The protein-folding procedure described in this article consists of two successive steps: a theoretical transition from an ideal alpha helix to an ideal beta sheet is first imposed on the protein conformation, in order to calculate an initial secondary structure. The most stable secondary structure is built from a combination of the lowest energy structures calculated for each amino acid during this transition. An angular molecular dynamics step is then applied to this secondary structure. In this computational step, the total energy of the system consisting of the sum of the torsional energy, the van der Waals energy, the electrostatic energy, and the solvation energy is minimized. This process yields 3-D structures of minimal total energy that are considered to be the most probable native-like structures for the protein. This method therefore requires no prior hypothesis about either the secondary or the tertiary structure of the protein and restricts the input of data to its sequence. The validity of the results is tested by comparing the crystalline and computed structures of four proteins, i.e., the avian and bovine pancreatic polypeptide (36 residues each), uteroglobin (70 residues), and the calcium-binding protein (75 residues); the C alpha-C alpha maps show significant homologies and the position of secondary structure domains; that of the alpha helices is particularly close. [less ▲]

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See detailBrazilandia. Over Brazil van John Updike.
Vanden Berghe, Kristine ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(1), 112-114

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See detailCloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.
Sheridan, P. L.; Schorpp, M.; Voz, Marianne ULg et al

in Journal of Biological Chemistry (1995), 270(9), 4575-87

We have isolated a human cDNA clone encoding HIP116, a protein that binds to the SPH repeats of the SV40 enhancer and to the TATA/inhibitor region of the human immunodeficiency virus (HIV)-1 promoter. The ... [more ▼]

We have isolated a human cDNA clone encoding HIP116, a protein that binds to the SPH repeats of the SV40 enhancer and to the TATA/inhibitor region of the human immunodeficiency virus (HIV)-1 promoter. The predicted HIP116 protein is related to the yeast SNF2/SWI2 transcription factor and to other members of this extended family and contains seven domains similar to those found in the vaccinia NTP1 ATPase. Interestingly, HIP116 also contains a C3HC4 zinc-binding motif (RING finger) interspersed between the ATPase motifs in an arrangement similar to that found in the yeast RAD5 and RAD16 proteins. The HIP116 amino terminus is unique among the members of this family, and houses a specific DNA-binding domain. Antiserum raised against HIP116 recognizes a 116-kDa nuclear protein in Western blots and specifically supershifts SV40 and HIV-1 protein-DNA complexes in gel shift experiments. The binding site for HIP116 on the SV40 enhancer directly overlaps the site for TEF-1, and like TEF-1, binding of HIP116 to the SV40 enhancer is destroyed by mutations that inhibit SPH enhancer activity in vivo. Purified fractions of HIP116 display strong ATPase activity that is preferentially stimulated by SPH DNA and can be inhibited specifically by antibodies to HIP116. These findings suggest that HIP116 might affect transcription, directly or indirectly, by acting as a DNA binding site-specific ATPase. [less ▲]

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See detailComment j'explore ... Une anorexie mentale.
Scheen, André ULg

in Revue Médicale de Liège (1995), 50(12), 538-9

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See detailThe hydrophobic effect in protein folding.
Lins, Laurence ULg; Brasseur, Robert ULg

in FASEB Journal (1995), 9(7), 535-40

In this review of protein folding we consider the noncovalent interactions existing between atoms or molecules at the molecular level. The electrostatic, Van der Waals, hydrogen bonding, and hydrophobic ... [more ▼]

In this review of protein folding we consider the noncovalent interactions existing between atoms or molecules at the molecular level. The electrostatic, Van der Waals, hydrogen bonding, and hydrophobic interactions are described and their contribution to protein conformation is discussed. The growing interest in the hydrophobic effect arises from its importance in the protein folding process, and a semiempirical simulation of the free energy of solvation is proposed. In most proteins, the different forces we describe contribute to the stability of the protein conformation in a complex way. However, in the case of the apolipoproteins and cytochrome C551, the energetic contributions are easily distinguished. For this reason, these proteins are used to illustrate the importance of the different energy fields. [less ▲]

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See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

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See detailModulation of acetylcholine, capsaicin and substance P effects by histamine H3 receptors in isolated perfused rabbit lungs.
Delaunois, Annie ULg; Gustin, Pascal ULg; Garbarg, M. et al

in European Journal of Pharmacology (1995), 277(2-3), 243-50

The modulatory role of histamine H3 receptors in pulmonary oedema induced by acetylcholine, capsaicin and by exogenous substance P was investigated in isolated, ventilated rabbit lungs. Endothelial ... [more ▼]

The modulatory role of histamine H3 receptors in pulmonary oedema induced by acetylcholine, capsaicin and by exogenous substance P was investigated in isolated, ventilated rabbit lungs. Endothelial permeability was evaluated by measuring the capillary filtration coefficient (Kf,c). Acetylcholine (10(-8) to 10(-4) M), substance P (10(-10) to 10(-6) M), capsaicin (10(-4) M) and 5-hydroxytryptamine (5-HT) (10(-4) M) induced an increase in the Kf,c. Carboperamide, a novel histamine H3 receptor antagonist, induced a significant leftward shift of the concentration-response curve to acetylcholine and also enhanced the effect of capsaicin on the Kf,c, while it had no significant effect on the response to substance P and 5-HT. Imetit, a new histamine H3 receptor agonist, strongly inhibited the effects of acetylcholine and capsaicin. Imetit also strongly protected the lung against substance P effects but did not prevent the 5-HT-induced increase in the Kf,c. Carboperamide completely blocked the inhibitory effect of Imetit on the acetylcholine response. (R)-alpha-Methylhistamine, an other histamine H3 receptor agonist, had the same protective effect against acetylcholine response as Imetit. We conclude that histamine H3 receptors could protect the lung against acetylcholine- and capsaicin-induced oedema via a prejunctional modulatory effect on the C-fibres. However, since the response to exogenous substance P was also inhibited by histamine H3 receptor stimulation, the presence of such receptors at a postsynaptic level, probably on mast cells, was also suggested. [less ▲]

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See detailDe réels progrès ont-ils été faits dans le traitement de l'ostéoporose ?
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Franchimont, P

in Medi-Sphere (1995), 39

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See detailAssociation Of Synthetic Peptide-Fragments Of Human Apolipoprotein-A-I With Phospholipids
Vanloo, B.; Demoor, L.; Boutillon, C. et al

in Journal of Lipid Research (1995), 36(8), 1686-96

The sequences of the plasma apolipoproteins have a high degree of internal homology as they contain several 22-mer internal repeats. These amphipathic helical repeats are considered as the structural and ... [more ▼]

The sequences of the plasma apolipoproteins have a high degree of internal homology as they contain several 22-mer internal repeats. These amphipathic helical repeats are considered as the structural and functional units of this class of proteins. We proposed that the 22-mer repeats of the plasma apolipoproteins consist of 17-mer helical segments separated by extended beta-strands comprising five amino acid residues with a proline in the center of this segment. These beta-strand segments help reverse the orientation of the consecutive helices of apoA-I, A-IV, and E in a discoidal apolipoprotein-phospholipid complex. In order to support this hypothesis, we synthesized apoA-I fragments consisting of, respectively, one putative helix (residues 166-183), one helix plus a beta-strand (residues 161-183), and a pair of helices separated by a beta-strand (residues 145-183). The structural and lipid-binding properties of these peptides were investigated by turbidity, fluorescence, binding studies with unilamellar phospholipid vesicles, electron microscopy, and circular dichroism measurements. Our data show that one single putative helical segment or one helical segment plus one extended beta-strand do not form stable complexes with phospholipids. The addition of a second adjacent helix has no influence on the lipid affinity of the apoA-I 145-183 peptide compared to the shorter segments but substantially improves the stability of the complexes. The helical content of the peptide increases upon lipid association as observed with apoA-I. The complexes generated with the apoA-I 145-183 peptide appear as discoidal particles by negative staining electron microscopy, with heterogeneous sizes ranging between 250 and 450 A. The relative orientation of the peptide and the phospholipid is the same as in a DMPC/apoA-I complex as the helices are oriented parallel to the acyl chains of the phospholipid. However, the stability of these complexes is significantly lower than that of the corresponding DMPC/apoA-I complexes. The transition temperature, fluidity, and cooperativity of the phospholipid bilayer are only weakly affected by the association with the apoA-I 145-183 peptide. These data suggest that a pair of helical peptides linked through a beta-strand associates more tightly with lipids and can form discoidal lipid-peptide complexes, than a single helix. A comparison with the properties of native apoA-I suggests, however, that the cooperativity between pairs of helices in native apoA-I further contributes to strengthen the lipid-protein association. [less ▲]

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See detailGrecs et Latins deux fois parents ? Aux origines de la conscience ethnique et linguistique des Grecs et des Romains
Rochette, Bruno ULg

in Cahiers de Clio (1995), 121-122(printemps-été), 69-84

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See detailLASH: laparoscopic supracervical (subtotal) hysterectomy
Donnez, Jacques; Smets, Mireille; Polet, Roland et al

in Zentralblatt für Gynakologie (1995), 117(12), 629-32

From July 1990 to December 1993, 156 laparoscopic supracervical hysterectomies (LASH) were performed. No complications occurred. The technique and the advantages are described. Because of the easy ... [more ▼]

From July 1990 to December 1993, 156 laparoscopic supracervical hysterectomies (LASH) were performed. No complications occurred. The technique and the advantages are described. Because of the easy feasibility of this technique, the quick recovery of the patients and the absence of complications this strictly laparoscopic approach must be widely proposed when an hysterectomy is indicated and no risk of remaining cervix cancer is assumed. [less ▲]

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See detailRecommendations for the registration of new chemical entities used in the prevention and treatment of osteoporosis
Reginster, Jean-Yves ULg; Compston, JE; Jones, EA et al

in Calcified Tissue International (1995), 57

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See detailL'étude de la langue russe à l'Université de Liège de 1899 à nos jours: historique, problématique et perspectives
Mouton, Charles ULg

in Actes du Colloque du Sart Tilman des 14 et 15 octobre 1994 (1995)

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See detailQui est Apollonios ? (UPZ II 227)
Rochette, Bruno ULg

in Aegyptus (1995), 75

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See detailAminoglycoside Antibiotics Induce Aggregation But Not Fusion Of Negatively-Charged Liposomes
Vanbambeke, F.; Tulkens, Pm.; Brasseur, Robert ULg et al

in European Journal of Pharmacology-Molecular Pharmacology Section (1995), 289(2), 321-33

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical ... [more ▼]

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical modifications of the membrane properties. This work examines the capacity of aminoglycosides to induce membrane aggregation and fusion. Three techniques were used in parallel: (i) measurement of the dequenching rate of a lipid-soluble fluorescent probe (octadecylrhodamine B) incorporated at self-quenched concentration in membranes; (ii) measurement of the increase in the energy transfer between two fluorescent derivatives of phospholipids; and (iii) electron microscopy of negatively-stained replicas. The results were compared with those obtained with spermine (an aggregating polycation) and melittin (a fusogenic peptide). The three approaches indicate that aminoglycosides induce liposomes aggregation, but not fusion. Aggregation is related to the capacity of each drug studied to bind phosphatidylinositol, as evaluated by its energy of interaction with this acidic phospholipid, and to its toxic potential. Membrane aggregation occurring in vivo could therefore contribute to, or be a determinant of this toxicity, which could rationally be screened for new derivatives by the methods applied here. [less ▲]

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See detailNuclear transplantation using bovine primordial germ cells from male fetuses.
Delhaise, F.; Ectors, Fabien ULg; de Roover, R. et al

in Reproduction, Fertility and Development (1995), 7(5), 1217-9

The developmental potential of nuclei of bovine gonial cells was investigated by nuclear transfer. Gonial cells were collected from male fetuses at about 175 days post coitum (p.c.). They were fused with ... [more ▼]

The developmental potential of nuclei of bovine gonial cells was investigated by nuclear transfer. Gonial cells were collected from male fetuses at about 175 days post coitum (p.c.). They were fused with enucleated oocytes; reconstituted embryos were cultured in vitro for 7 days. Embryos reaching the compacted morula or blastocyst stage were either fixed for cell counting or transferred into recipients. Out of 115 oocyte-gonia fusions, 101 (87.8%) gave rise to cleaved embryos at Day 3 and 26 (22.6%) had reached the 8-cell stage. At Day 7, 1 (1%) developed to the morula stage and 5 (4%) reached the blastocyst stage. Three blastocysts were fixed and showed normal cell numbers (135; 90; 76 cells). Three blastocysts and one morula were transferred in four recipients; two recipients were pregnant at Day 21 but only one was positive at Day 35 p.c.; this last one aborted around Day 40 p.c. No conceptus was collected. These results indicate that gonial cell nuclei can be partially reprogrammed; they are able to develop into blastocysts and to initiate gestation. However, more experiments will be necessary to prove the nuclear totipotency of bovine gonial cells. [less ▲]

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See detailMapping quantitative trait loci controlling milk production by exploiting progeny testing
Georges, Michel ULg; Nielsen, D.; Mackinnon, M. et al

in Genetics (1995), 139

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny ... [more ▼]

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding. [less ▲]

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See detailVaricella-zoster virus : Introduction
Rentier, Bernard ULg

in Neurology (1995), 45(12, suppl. 8), 8

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See detailResponses to mCPP stimulation in depressed patients.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in American Journal of Psychiatry (The) (1995), 152(12), 18341834-5

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See detail3-Methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailIS THE PRESENCE OF MESOTROPHIC PLANT-COMMUNITIES IN THE PEAT-BOGS OF HAUTES-FAGNES (BELGIUM) CONNECTED WITH TONALITE INTRUSIONS IN THE REVINIAN LAYERS
Hambuckers, Alain ULg; Schumacker, René ULg; Remacle, Jean ULg et al

in Belgian Journal of Botany (1995), 128(1), 48-56

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species ... [more ▼]

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species. Based on the fact that there are several outcrops of tonalite in the region and particularly one in the Nature Reserve, a hypothesis to explain these singularities of the vegetation implies discontinuities of the bedrock provoked by intrusions of this magmatic rock in the Revinian layer covering the region. Seventeen plots containing Phragmites australis were examined and vegetation was described. Silt and soil water were sampled and analyzed for mineral contents in 15 sites. The differences of mineral composition between the P. australis plots and their surrounding environment confirmed the more mesotrophic characteristics of these plots (i.e. higher pH, higher Ca and Mg contents, lower Al content). However, the lower Zn, Pb and Fe contents would lead to reject the hypothesis of intrusions of tonalite since these elements are more abundant in the tonalite and its mineralization than in the Revinian rock. Nevertheless, the overall ecological conditions of the examined plots and the differences of plant species composition suggested that the observed chemical environment could be evoked for explaining the distribution of the mesotrophic species in the oligotrophic environment of the Nature Reserve. Consequently, an alternative hypothesis is proposed. [less ▲]

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See detailBases biologiques du comportement suicidaire: approche neuroendocrinienne et psychophysiologique du role des catecholamines.
Pitchot, William ULg; Hansenne, Michel ULg; Gonzalez Moreno, Antonio et al

in Acta Psychiatrica Belgica (1995), 95(4-5), 210-33

The current main neurochemical theories of the biological correlates of suicidal behavior principally involve the serotonergic system. Few data are available about the possible role of the ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior principally involve the serotonergic system. Few data are available about the possible role of the catecholaminergic (noradrenergic and dopaminergic) function. In the present study, in a first part, we assessed the growth hormone (GH) response to clonidine, a selective alpha 2-adrenergic agonist, and to apomorphine, a dopaminergic agonist, in 22 DSM-III-R major depressive male inpatients with a history of suicide attempts compared to 22 age-matched major depressive inpatients without history of suicidal behavior. Hormonal responses to clonidine and apomorphine were also compared with 4.00 PM postdexamethasone cortisol levels. The two groups differed significantly in the GH peak response after apomorphine: 6.27 +/- 3.18 ng/ml in suicide attempters vs 17.40 +/- 14.87 ng/ml in nonattempters (F = 11.78, p = 0.001). There was no statistically significant difference between the two groups for GH peak responses after clonidine. Moreover, mean postdexamethasone cortisol levels did not exhibit any significant difference between suicide attempters and nonattempters. Violent and nonviolent attempters did not differ on any of the biological measures. In a second part, P300 and contingent negative variation (CNV) were recorded in 20 depressive inpatients subgrouped into suicide attempters (n = 10) and nonattempters (n = 10). The results showed a significant reduction of both P300 and CNV amplitudes in patients who attempted suicide compared to patients without history of suicide attempts. Moreover, a significant correlation was found between the Suicidal Risk scale and CNV amplitude. In conclusion, these results suggest that a dopaminergic hypoactivity as assessed by a blunted GH response to apomorphine and by a reduction of both P300 and CNV amplitudes, could be considered as a biological correlate of suicidal behavior. In contrast, noradrenergic disturbances, particularly at the level of alpha 2-adrenergic receptors, seem to play a more minor role. Moreover, DST nonsuppression cannot be considered as a biological marker of suicidal behavior. [less ▲]

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See detailClinical neurophysiology and neurotransmitters
MAERTENS DE NOORDHOUT, Alain ULg; Wang, Wei; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1995), 15(4), 301-9

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional ... [more ▼]

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional evaluation of neurotransmission at the neuromuscular junction, in some spinal interneurons and intracortical circuits as well as evaluation of pharmacological modulation of some electrophysiological tests. These investigations are carried out to help our understanding of the pathophysiology of brain diseases. Finally, we discuss possible relationships between electrophysiological tests (evoked/event-related potentials and exteroceptive suppression of temporalis muscle activity) and neurotransmitter function in headache. [less ▲]

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See detailUtilisation des biopesticides pour la protection de pommes en conservation.
Jijakli, Mohamed ULg; Lepoivre, Philippe ULg

in Fruit Belge (1995), 63(455), 83-88

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See detailThe mh gene causing double-muscling in cattle maps to bovine chromosome 2
Charlier, Carole ULg; Coppieters, Wouter ULg; Farnir, Frédéric ULg et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1995), 6

While the hereditary nature of the double-muscling phenotype (a generalized muscular hypertrophy documented in several cattle breeds) is well established, its precise segregation mode has remained ... [more ▼]

While the hereditary nature of the double-muscling phenotype (a generalized muscular hypertrophy documented in several cattle breeds) is well established, its precise segregation mode has remained controversial. Both monogenic models (autosomal dominant or recessive) and oligogenic models have been proposed. Using a panel of 213 bovine microsatellite markers, and an experimental pedigree obtained by backcrossing double-muscled (Belgian Blue)xconventional (Friesian) F1 dams to double-muscled sire, we have mapped a locus on bovine Chromosome (Chr) 2 that accounts for all the phenotypic variance in the backcross generation. This locus, referred to as mh (muscular hypertrophy), has been positioned with respect to a map composed of seven Chr 2-specific microsatellites, at 2 cM from the closest marker. This result confirms the validity in the Belgian Blue population of the monogenic model involving an autosomal mh locus, characterized by a wild-type + and a recessive mh allele, causing the double-muscling phenotype in the homozygous condition. The linkage relationship between the mh locus and the Chr 2 markers was confirmed in three informative pedigrees collected from the general Belgian Blue Cattle population, reinforcing the notion of genetic homogeneity of the double-muscling trait in this breed. This work paves the way towards marker-assisted selection for or against the double-muscling trait, and towards positional cloning of the corresponding gene. [less ▲]

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See detailAn Atypical Anion Transporter Functioning at Acid pH in Neuroblastoma Cells
Bettendorff, Lucien ULg; Margineanu, Ilca; Wins, Pierre et al

in Biochemical and Biophysical Research Communications (1995), 207(1), 375-381

At pH 7.4, 36Cl- uptake by neuroblastoma cells was Na(+)-independent, saturable and blocked by submicromolar concentrations of DIDS. This suggests that at this pH, Cl- transport is mediated by an ... [more ▼]

At pH 7.4, 36Cl- uptake by neuroblastoma cells was Na(+)-independent, saturable and blocked by submicromolar concentrations of DIDS. This suggests that at this pH, Cl- transport is mediated by an exchanger analogous to erythroid band 3. At pH 6. [less ▲]

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See detailÉvolution technique au Paléolithique ancien de Karain (Turquie)
Otte, Marcel ULg; Yalçinkaya, Isin; Kozlowski, Janusz et al

in Anthropologie (L') (1995), 99(4), 529-561

The Karain Cave, in Southern Turkey, provided a long sequence pf Lower and Middle Palaeoliothic. A "Clactonian" type flake industry is present at the basis, with numerous denticulates and notches. The ... [more ▼]

The Karain Cave, in Southern Turkey, provided a long sequence pf Lower and Middle Palaeoliothic. A "Clactonian" type flake industry is present at the basis, with numerous denticulates and notches. The evolution is marked by the development of the elaborated preparation of flakes leading to the Levallois technology. Four climatic cycles were recognized, each with an alternance of a long cold phase and thinner tempered deposits. The now available radiometric datations place the last tempered phase around 120 to 100,000 years. [less ▲]

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See detailAspects hémodynamiques de l'insulinorésistance: des concepts théoriques à la thérapeutique.
Paquot, Nicolas ULg; SCHEEN, André ULg; Lefebvre, P.

in Médecine et Hygiène (1995), 53

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See detailMechanisms of substance P-induced pulmonary oedema in the rabbit: interactions between parasympathetic and excitatory NANC nerves.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Fundamental & Clinical Pharmacology (1995), 9(5), 450-7

The pharmacological mechanisms involved in the substance P (SP)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. Substance P induced a dose-dependent increase in the capillary ... [more ▼]

The pharmacological mechanisms involved in the substance P (SP)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. Substance P induced a dose-dependent increase in the capillary filtration coefficient (Kf,c), responsible for oedema. Atropine, hemicholinium-3 and ruthenium red pretreatment partly protected the lungs against SP effects, while tetrodotoxin and hexamethonium did not significantly modify them. (+/-)CP96,345, a NK1 receptor antagonist, completely inhibited the SP-induced increase in the Kf,c. Like SP, acetylcholine (ACh) and capsaicin also increased the Kf,c. Atropine and (+/-)CP96,345 completely blocked the oedema induced by both drugs. Tetrodotoxin and ruthenium red strongly inhibited the response to capsaicin and acetylcholine. It was concluded that SP-induced pulmonary oedema is in part mediated by a stimulating action on cholinergic efferent nerves, with subsequent release of endogenous acetylcholine. Acetylcholine can, in turn, stimulate the release of SP from excitatory non adrenergic, non cholinergic nerves. The effects induced by capsaicin and exogenous acetylcholine, thus endogenous SP, involve tetrodotoxin-sensitive mechanisms, while those produced by exogenous SP are tetrodotoxin-resistant. [less ▲]

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See detailAvantages environnementaux de l'élevage de porcs sur litière biomaîtrisée
Nicks, Baudouin ULg; Desiron, Alain; Canart, Bernard

in Nouvelles de la Science et des Technologies (1995), 13

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See detailRetinopathy, but not neuropathy, is influenced by the level of residual endogenous insulin secretion in type 2 diabetes.
Bozet, Marie-Claire ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Diabète & Métabolisme (1995), 21(5), 353-9

The files of 132 patients with Type 2 diabetes were retrospectively studied to characterize the influence of metabolic control and residual insulin secretion on neuropathy and retinopathy, the two most ... [more ▼]

The files of 132 patients with Type 2 diabetes were retrospectively studied to characterize the influence of metabolic control and residual insulin secretion on neuropathy and retinopathy, the two most frequent degenerative diabetic complications. Patients were classified according to their metabolic control (mean HbA1C either < or > or = 8%; reference values: 3-6%) and residual endogenous insulin secretion (fasting plasma C-peptide levels either < or > or = 0.600 nmol/l). Neuropathy was more frequent in patients with poor metabolic control (32/64 = 50%) than in those adequately controlled (17/68 = 25%; p < 0.005). In both subgroups, the level of endogenous insulin secretion did not influence the prevalence of neuropathy. Retinopathy was less effected than neuropathy by the degree of metabolic control (37.5% in the subgroup with HbA1C > or = 8% v.s. 25% in the subgroup with HbA1C < 8%; p < 0.10), but was influenced by residual insulin secretion. Indeed, in patients with inadequate metabolic control, the prevalence of retinopathy was significantly increased in those with higher endogenous insulin secretion (51.4 versus 20.6%, p < 0.02) and thus probably higher insulin resistance. Furthermore, higher systolic arterial blood pressure was observed in the subgroups with a higher prevalence of retinopathy. Such conclusions were confirmed using multivariate analysis. Thus, in Type 2 diabetes, neuropathy is essentially affected by the degree of metabolic control, whereas retinopathy is also influenced by the level of residual endogenous insulin secretion and the presence of systolic hypertension. [less ▲]

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See detailGale auriculaire du lapin et des carnivores domestiques : efficacité d’un gel phyto-aromatique
Mignon, Bernard ULg

in Action Vétérinaire (1995), suppl 1343

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See detailGrecs et Latins face aux langues étrangères. Contribution à l'étude de la diversité linguistique dans l'antiquité classique
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (1995), 73(1), 5-16

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See detailA experiência Pedagógica «Renovação do Ensino Elementar - Desenvolvimento Corporal das Crianças dos 2,5 Anos aos 12 Anos»
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Boletim Sociedade Portuguesa de Educação Física (1995), 12(2), 31-58

This paper presents the methodology and main results of a research program aiming to identify the effect of a daily physical education project implemented in the French speaking part of Belgium.

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See detailThermographie routière nocturne de la Région Wallonne : méthodologie, présentation des résultats et intérêts de l'approche topoclimatologique
Funcken, Ph.; Erpicum, Michel ULg; Frédéric, Marc ULg et al

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailConnections and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Costruzioni Metalliche (1995), n°4

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See detailIndice plasmodique et parasitémie à Plasmodium falciparum: valeur diagnostique et pronostique au Congo.
Carme, B.; Hayette, Marie-Pierre ULg; Mbitsi, A. et al

in Annales de la Société Belge de Médecine Tropicale (1972) (1995), 75

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the ... [more ▼]

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the intention of establishing diagnosis and prognosis value of Plasmodium falciparum parasitaemia in areas with high perennial transmission. In such an area Congolese school children (6-10 years old) had 88% P. falciparum index, this is the same percentage as that for children hospitalized with a pernicious attack. However, the parasite load is distributed differently; parasitaemia is greater than 6,000 asexual form for P. falciparum (af/Pf/µl) in only 4,6% of cases in the former group, versus 67% in the second group. A threshold of 10,000 af/Pf/µl above which the Plasmodium infection triggers a febrile attack in semi-immune children, is confirmed in school children in a rural context where the factor of taking antimalarial drugs within the preceding days is negligible: three out of four children with levels above this threshold are febrile versus 4,1% (7 out of 170) with lower blood parasite levels. Some adults where also asymptomatic carriers but much less frequently and with lower mean parasitaemia levels. The parasite load mirrors the clinical severity although this concept can be misleading as an individual prognostic criterion and foor hospital studies carried out in areas where multiple drug administration before hospitalization is common. For the studies recently performed in Brazzaville, the 5% threshold of parasitized red cells, the WHO severity criterion was never reached in asymptomatic subject or in cases of simple attack; it was reached in one out of two cases of pernicious attack. [less ▲]

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See detailLa prise en compte des contraintes environnementales en élevage: code de bonnes pratiques et aspects réglementaires
Nicks, Baudouin ULg

in Annales de Médecine Vétérinaire (1995), 139(5), 327-334

As all other activities, livestock production represents a risk of nuisances for the environment. The author describes the risks of causing water pollution from applying livestock wastes to land and the ... [more ▼]

As all other activities, livestock production represents a risk of nuisances for the environment. The author describes the risks of causing water pollution from applying livestock wastes to land and the risks of air pollution from odours and ammonia. The agricultural practices which minimise the nuisances and the Belgian environmental protection laws concerning the building of animal houses and the disposal of farm wastes are presented [less ▲]

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See detailTreatment of Clostridium difficile colitis. Summary of a round table held in Brussels on March, 3rd, 1994.
Delmée, Michel; Melin, Pierrette ULg; Peetermans, Willy et al

in Acta Clinica Belgica (1995), 50(2), 114-6

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea ... [more ▼]

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea with metronidazole while maintaining the use of oral vancomycin in serious or life-threatening colitis. Clostridium difficile is a common cause of diarrhoea after antibiotic therapy and induces a spectrum of diseases ranging from mild diarrhoea to pseudomembranous colitis (PMC). It is considered to be the first cause of diarrhoea occurring among hospitalized patients (1). [less ▲]

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See detailRéalisation d'un appareillage mesure de l'anisotropie magnétique et application aux supraconducteurs à haute température critique
Vanderbemden, Philippe ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1995), 12

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See detailCeci est mon corps
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5),

This is a special issue on the body in literature and art.

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See detailUnaudited clinical experience.
NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (1995), 63(4), 934-5

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See detailThe Anatolian Middle Palaeolithic. New Research at Karain Cave
Otte, Marcel ULg; Yalçinkaya, Isin; Taskiran, Harun et al

in Journal of Anthropological Research (1995), 51(4), 287-299

The aims of this report are three-fold: i. to provide new informattion concerning the Palaeolithic of Turkey; ii. to present the shifts in lithic techniques évidenced during this period; and iii. to ... [more ▼]

The aims of this report are three-fold: i. to provide new informattion concerning the Palaeolithic of Turkey; ii. to present the shifts in lithic techniques évidenced during this period; and iii. to demonstrate significance of the new information for interpreting long distance relations between Western Asia and Europe. In fact, in spite of the crucial geographic situation of Anatolia between the Near East and Europe, it has rarely been the subject of intensive excavations and publications concerning the Paleolithic periods. Recently obtained data are therefore of significant interest. [less ▲]

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See detailPlace de l'érythropoiétine recombinante en période périopératoire
Janssens, Marc ULg; Lamy, Maurice ULg

in Annales Françaises d'Anesthésie et de Réanimation (1995), 14(Suppl 1), 98-106

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See detailLes activateurs de canaux potassiques: étude structurale comparative du pinacidil, du diazoxide et du cromakalim
Dupont, Léon ULg; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Annales Pharmaceutiques Françaises (1995), 53(5), 201-208

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers ... [more ▼]

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers has been reoptimized using the AM1 semiempirical Molecular Orbital method (MOPAC 5.0), and the total energy of the optimized conformers has been compared. In spite of an apparent structural dissimilarity, a good analogy has been found between the calculated isopotential map of diazoxide and that of at least one selected low energy conformer of pinacidil. It has been suggested that, unlike cromakalim, the low but observable activity of pinacidil on pancreatic B-cells could be explained by adoption for this compound of a conformation having a diazoxide-like stereoelectronical imprint which could assume a similar interaction on the same biological receptor. [less ▲]

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See detailBiochemical analysis of cytoplasmic and mitochondrial Asn-tRNA synthetase functions in two mutant yeast strains.
Landrieu, Isabelle; Vandenbol, Micheline ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103

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See detailEffect of high osmolarity acclimation on tolerance to hyperosmotic shocks in L929 cultured cells.
Gilles, Raymond ULg; Belkhir, M.; Compère, Philippe ULg et al

in Tissue & Cell (1995), 27(6), 679-687

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin ... [more ▼]

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin. This paper shows that; 1) this phenomenon is concomitant with a complete disappearance of deoxyribonucleic acid, as visualized by immunogold labelling, from the nucleoplasmic spaces; 2) acclimation to high osmolarities (600 mOsm) by addition to the culture medium of NaCl, sorbitol or proline protects the cells from these effects, which appear to be largely attenuated-acclimated cells also survive much better to the osmotic shock than do control cells and; 3) the best protection seems to be provided by sorbitol and NaCl. Proline acclimation is less effective. These effects are discussed in terms of increased tolerance to NaCl load induced at the level of different macromolecules by so-called 'compensatory' organic compounds. [less ▲]

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See detailThrombospondin modulates human breast adenocarcinoma cell adhesion to human vascular endothelial cells.
Incardona, F.; Lewalle, J. M.; Morandi, V. et al

in Cancer Research (1995), 55(1), 166-73

hrombospondin (TSP), a M(r) 450,000 cytoadhesive glycoprotein, has been shown to potentiate tumor cell metastasis in mice by a mechanism that involves the hemostatic system of the host. In this study, the ... [more ▼]

hrombospondin (TSP), a M(r) 450,000 cytoadhesive glycoprotein, has been shown to potentiate tumor cell metastasis in mice by a mechanism that involves the hemostatic system of the host. In this study, the potential involvement of TSP in the interaction of human mammary adenocarcinoma MCF-7 cells with human umbilical vein endothelial cells (HUVECs) in culture was investigated. Using an ELISA, preconfluent HUVECs synthesized 100-fold more TSP than did MCF-7 cells during 24 h of culture (20 versus 0.2 microgram/10(6) cells). Confocal microscopy localized TSP within intercellular junctions between aggregated MCF-7 cells in suspension. On adherent cells, TSP exhibited a patchy distribution both on the cell surface and in the cytosol. In HUVECs, TSP strongly stained the perinuclear space and was also found in association with cytoskeletal microfibrils. Flow cytometric analysis indicated the presence of a large number of unoccupied receptors for TSP on MCF-7 cells. Binding studies using [125I]TSP demonstrated the presence of 1.6 x 10(6) sites/cell with an apparent Kd of 28 nM. Attachment of radiolabeled MCF-7 cells to a TSP-coated substrate and to HUVEC monolayers was inhibited in the presence of a polyclonal antibody to TSP (10 micrograms/ml) or increasing concentrations (1-10 micrograms/ml) of soluble TSP. Neither nonimmune IgG nor the cell adhesion peptide Gly-Arg-Gly-Asp-Ser (100 micrograms/ml) inhibited these interactions. Inhibition was also observed with heparin (10 micrograms/ml), suggesting the participation of TSP heparin-binding domain(s) and heparin-like molecules. In the presence of an excess of soluble TSP or anti-TSP antibody, MCF-7 cells did not form aggregates in suspension and preformed aggregates were readily dissociated by the addition of soluble TSP. These results indicate that mammary adenocarcinoma cells use TSP to form aggregates and to attach to human endothelial cells. These interactions may have physiological implications during the hematogenous spread of tumor cells. [less ▲]

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See detailContrôle du phytoplancton du bassin ligure par le front liguro-provençal (secteur corse)
Goffart, Anne ULg; Hecq, Jean-Henri ULg; Prieur, Louis

in Oceanologica Acta (1995), 18

The evolution of the phytoplankton distribution was followed along the Calvi - Nice axis, from Calvi to 30 miles offshore, in relation with the hydrological features of the Liguro-Provençal front ... [more ▼]

The evolution of the phytoplankton distribution was followed along the Calvi - Nice axis, from Calvi to 30 miles offshore, in relation with the hydrological features of the Liguro-Provençal front (Corsican sector) and the nutrients disponibility. Oceanographic cruises repeated between 1982 and 1991 have emphasized the permanence of the front and the interannual stability of its hydrological characteristics. Moreover, the front and the associated vertical circulation influenced highly, and in a reproducible way, the algal distribution within distances of few kilometres. In March, within the Ligurian current (on the coastal side), the front and the central zone (on the open sea side), stabilization of upper layers of water column, induced by a beginning of vertical stratification, is the main factor controlling the starting of the bloom. As soon as phytoplankton development is initiated, highest values of chlorophyll a and primary production are observed in the frontal area. During spring, a significant amount of the phytoplankton produced in the surface layer was carried down along the isopycnals in relation with the frontal convergence. As a consequence, the chlorophyll a distribution was typically like a plume, extending from the surface to at least 100 m deep. In all zones, during the stratified period, the position of the chlorophyll a maximum in the water column is determined by the opposing gradients of light and nitrate. In May, the maximum of phytoplankton was permanently observed in the frontal area where it was strictly correlated with the nitracline. A sharp core of high chlorophyll a concentrations was also observed in the central zone while the Ligurian current was characterized by very low pigment levels. During that period, the ecological role of the front seems to be particularly important because it delimits the unique area of enhanced phytoplanktonic biomass in an oligotrophic or very oligotrophic environment. In June, a well-developed deep chlorophyll a maximum was observed everywhere, from the central zone to the coast. The contribution of the front to the enhancement of the biomass appears to be less important than during spring. [less ▲]

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See detailModified glucagon test allowing simultaneous estimation of insulin secretion and insulin sensitivity: application to obesity, insulin-dependent diabetes mellitus, and noninsulin-dependent diabetes mellitus.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Journal of Clinical Endocrinology and Metabolism (1995), 80(2), 393-9

The aim of this study was to describe an adaptation of the glucagon test allowing the simultaneous characterization of insulin secretion and sensitivity. A glucagon test (1 mg/m2) was performed in healthy ... [more ▼]

The aim of this study was to describe an adaptation of the glucagon test allowing the simultaneous characterization of insulin secretion and sensitivity. A glucagon test (1 mg/m2) was performed in healthy subjects (n = 11), obese patients (n = 5), insulin-dependent diabetics (n = 9), nonobese noninsulin-dependent diabetics (n = 7), and overweight noninsulin-dependent diabetics (n = 8). Previously, they had been connected to the Biostator, modified for continuous blood collection. Endogenous insulin secretion induced by glucagon was derived from integrated C-peptide concentrations. An index of insulin sensitivity was obtained by dividing the rate of decrease in blood glucose by the total amount of insulin entering the circulation (secreted+infused by the Biostator). The indices of insulin sensitivity obtained in the above groups of subjects were, respectively, 0.064 +/- 0.006, 0.030 +/- 0.006, 0.037 +/- 0.007, 0.021 +/- 0.006, and 0.016 +/- 0.002 mmol/L.U.min (P < 0.001). The estimated insulin secretion values in the 20 min following glucagon injection were, respectively, 0.38 +/- 0.05, 0.65 +/- 0.08, 0.05 +/- 0.01, 0.26 +/- 0.15, and 0.30 +/- 0.07 U (P < 0.001). The insulin sensitivity index obtained from this test correlated with the glucose MCR obtained from a euglycemic glucose clamp (r = 0.816; P < 0.001; n = 12). C-Peptide levels after glucagon administration were also significantly correlated with the estimated endogenous insulin secretion (r = 0.808; P < 0.001; n = 30). This adaptation of the classical glucagon test is an efficient and simple method to simultaneously evaluate insulin secretion and insulin sensitivity. [less ▲]

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See detailFeed restriction and IGFBP in bulls: effects of increasing starving period lengths.
Massart, Serge; Van Eenaeme, Christian ULg; Renaville, Robert ULg et al

in Journal of Animal Science (1995), 73(suppl 1), 225

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See detailNimesulide
Dupont, L.; Pirotte, Bernard ULg; Masereel, B. et al

in Acta Crystallographica (1995), C51

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See detailDeux chansons relatives à des imprimeries liégeoises du XVIIIe siècle
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1995), 268

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See detailHelix Helix Interactions In Reconstituted High-Density-Lipoproteins
Lins, Laurence ULg; Brasseur, Robert ULg; De Pauw, Mc. et al

in Biochimica et Biophysica Acta-Lipids and Lipid Metabolism (1995), 1258(1), 10-8

In this work we calculated the ionic interactions between adjacent amphipathic helices of apo A-I and apo A-IV. The calculation of the electrostatic potential around the helices helps identify the charged ... [more ▼]

In this work we calculated the ionic interactions between adjacent amphipathic helices of apo A-I and apo A-IV. The calculation of the electrostatic potential around the helices helps identify the charged residues susceptible to form salt bridges between adjacent helices. An estimation of the stability of the different pairs of helices is derived from the calculation of the energy of interaction between contiguous helices at a water/lipid interface after energy minimization. The most stable energetic conformation corresponds to the 17-residue helices oriented anti-parallel and separated by a stretch of 5 residues in an extended beta-strand conformation, as calculated through the 'stereo alphabet' calculation procedure. In a pair of helices, the hydrophobic faces are directed towards the lipid core of the discoidal phospholipid-apolipoprotein complex and the hydrophobic lipid-protein interactions are major determinants for the stability of the complex. Interactions between polar residues located on the opposite face of the helix and water molecules can also contribute to the overall energy of the system. Finally, salt bridge formation between residues of opposite charge along the edge of the helical segments contribute to the cooperativity of the phospholipid-apolipoprotein complex formation. The mode of assembly of the amphipathic helical repeats of the apolipoproteins around the edge of a discoidal complex is therefore determined both by the hydrophobic character of the residues and by the charge complementarity along the edge of the helices which increases the structural stability and determines the relative orientation of the helices. [less ▲]

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See detailProblèmes rencontrés par des stagiaires dans l’enseignement des activités physiques et sportives. Analyse par la technique des incidents critiques
Beckers-Ledent, Maryse; Delfosse, Catherine; Cloes, Marc ULg et al

in Revue de l'Education Physique (1995), 35(1), 37-48

Les auteurs se sont attachés à identifier les problèmes rencontrés par des futurs enseignants lorsqu'ils font face à une classe. Il est évident qu'il est primordial de dépasser le simple aspect descriptif ... [more ▼]

Les auteurs se sont attachés à identifier les problèmes rencontrés par des futurs enseignants lorsqu'ils font face à une classe. Il est évident qu'il est primordial de dépasser le simple aspect descriptif des problèmes pour analyser les conduites adoptées par l'enseignant pour les résoudre et de découvrir sa perception de l'efficacité de son intervention. [less ▲]

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