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See detailAnti-LFA-1 (CD11a) monoclonal antibody interferes with the induction of neonatal tolerance to alloantigens
Schurmans, Stéphane ULg; Gonzalez, A.; Revilla, C. et al

in European Journal of Immunology (1994), 24

The injection of (C57BL/6 x BALB/c)F1 spleen cells into newborn BALB/c mice results in the induction of a specific cytotoxic T lymphocyte (CTL) tolerance to the alloantigens. On the contrary, alloreactive ... [more ▼]

The injection of (C57BL/6 x BALB/c)F1 spleen cells into newborn BALB/c mice results in the induction of a specific cytotoxic T lymphocyte (CTL) tolerance to the alloantigens. On the contrary, alloreactive CD4+ T cells persist in the host and are still able to activate autoreactive F1 B cells to produce autoantibodies. This state of "split tolerance" is closely associated with the development of a lupus-like autoimmune syndrome. The LFA-1 integrin plays a relevant role in homing, intercellular adhesion and tranduction of co-stimulatory signals in leukocytes. Because of the beneficial effects of anti-LFA-1 monoclonal antibodies (mAb) treatment in various models of organ transplantation and autoimmune disease, we have investigated if such a treatment could interfere with the induction of neonatal tolerance or the development of the autoimmune syndrome in F1 cell-injected newborn mice. For this purpose, BALB/c mice neonatally injected with F1 cells were treated from day 1 up to day 15 with a non-cytotoxic anti-LFA-1 (CD11a) mAb. Anti-LFA-1 mAb treatment interfered with the persistence of a stable chimerism and with the establishment of CTL tolerance, as shown by rejection of allogeneic skin grafts and F1 B cells, and by a normal in vitro CTL activity against the corresponding alloantigens. As a consequence, these mice did not develop the characteristic autoimmune features seen in close association with an effective induction of CTL tolerance to alloantigens. These results stress the importance of the interactions between LFA-1 and its ligands during the neonatal induction of tolerance to alloantigens [less ▲]

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See detailH3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach.
Bado, A.; Moizo, L.; Laigneau, J. P. et al

in Yale Journal of Biology and Medicine (The) (1994), 67(3-4), 113-121

We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin ... [more ▼]

We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin release (GR) and somatostatin release (SR) by the isolated rat stomach. Carbachol dose-dependently stimulated and inhibited GR and SR, respectively. Maximal stimulation of GR (500 +/- 112 percent of basal; p < .01), and maximal inhibition of SR (-62 +/- 9 percent under basal; p < .01) were obtained with 1 micron carbachol. Neither (R)alpha-MeHA nor Thiop, up to 10 microns, affected GR. However, SR was dose-dependently enhanced by Thiop (25 +/- 8 percent for 10 microns). Carbachol stimulation of GR was strongly inhibited by Thiop (30 +/- 7 percent for 100 nM and 73 +/- 14 percent for 1 microgram), whereas it was potentiated by (R)alpha-MeHA. Carbachol inhibition of SR was reversed by Thiop and (R)alpha-MeHA. However, the reversal effect of (R)alpha-MeHA was prevented by the CCKB/gastrin receptor antagonist PD134308. These results support H3-receptor regulation of basal and cholinergically-stimulated GR and SR. [less ▲]

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See detailAdvanced endoscopic techniques used in dysfunctional bleeding, fibroids and endometriosis, and the role of gonadotrophin-releasing hormone agonist treatment.
Donnez, Jacques; NISOLLE, Michelle ULg; Clerckx, Françoise et al

in British Journal of Obstetrics & Gynaecology (1994), 101(suppl 10), 2-9

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See detailMolecular Analysis Of The Ycr-242 Gene Encoding The Putative Mitochondrial Asparaginyl-Transfer-Rna Synthetase From Saccharomyces-Cerevisiae
Landrieu, I.; Vandenbol, Micheline ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailReaction Dynamics of Collisionally activated Ammonia Cations.
Leyh, Bernard ULg; Hoxha, A.

in Chemical Physics (1994), 179

In the framework of a research on the collisional mechanisms involved in tandem mass spectrometry, the collisional activation processes of NH3+ with different target gases have been investigated. The ... [more ▼]

In the framework of a research on the collisional mechanisms involved in tandem mass spectrometry, the collisional activation processes of NH3+ with different target gases have been investigated. The experiments have been performed on an upgraded AEI-MS9 sector instrument equipped with two collision cells and include daughter ion spectra, ion kinetic energy spectra, determination of kinetic energy release distributions (KERD) and appearance energy measurements. We have shown that collisionally activated dissociation (CAD) of NH3+ into NH++[H,H] depends upon the internal energy of NH3+. This internal energy effect is also observed for the NH2++H channel, when Xe is the target gas; with He, such an effect could not be detected. The analysis of the KERD shows that production of NH2+ upon CAD takes place from the NH3+ ground electronic state by rotational predissociation; two components are observed, one which corresponds to a near-threshold process (mean kinetic energy release <T>=0.13 eV), and one characterized by <T>=0.56 ev corresponding to an excess energy of 2.1 eV above the dissociation threshold. NH+ fragments can be formed by two processes: the first one occurs at threshold and leads to NH+(X2Pi)+H2(X1Sigma+g); the second one is characterized by large KER values (up to 7 eV) and leads to either electronically excited NH+ or dissociation of H2. [less ▲]

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See detailLe tamoxifene dans le traitement du cancer du sein
Charlier, Corinne ULg; Colin, Claude ULg; Merville, Marie-Paule ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(7), 751-6

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on ... [more ▼]

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on oral adjuvant therapy in the early stages of breast cancer. A significative regression of the tumour was observed in most cases. Moreover, recent epidemiological studies suggest that tamoxifen could prevent new contralateral primary tumours. The risk of the disease should thus be reduced by the prophylactic use of antioestrogens such as tamoxifen. Investigations using a variety of models have evaluated the effect of tamoxifen on tumour promotion and cell growth. Tamoxifen-induced growth inhibition is associated with major changes in biochemical events in cultured human breast cancer cells including cell proliferation or growth factor production. Growth inhibition of oestrogen-responsive human breast cancer cells is associated with an induced secretion of autoinhibitory polypeptides (TGF beta) and an antagonistic effect on the synthesis of proliferative proteins (TGF alpha,...). The first step in the mechanism of action of the drug is binding of tamoxifen to the oestrogen receptors. Development of resistance to tamoxifen treatment is a great problem in treatment of breast cancer patients and the mechanism of resistance will require further study: under the influence of the drug, tumours could become remodelled as selected subpopulations emerge resistant-tamoxifen. The fact that some breast cancers which are oestrogen receptor-negative respond to antioestrogen suggests that parallel but separate pathways for oestrogen and antioestrogen action may exist. This paper summarizes the results of the most recent studies concerning this promising drug. [less ▲]

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See detailCONTINUOUS ENZYMATIC-SYNTHESIS OF 2'-DEOXYTHYMIDINE-5'(ALPHA-D-GLUCOPYRANOSYL)DIPHOSPHATE
Zervosen, Astrid ULg; ELLING, Lothar; KULA, Maria-Regina

in Angewandte Chemie (International ed. in English) (1994), 33(5), 571-572

The preparation of primary nucleotide sugars like dTDP-glucose with sucrose synthase, a glycosyl transferase in plants, provides an alternative in enzymatic synthesis to the use of highly specific ... [more ▼]

The preparation of primary nucleotide sugars like dTDP-glucose with sucrose synthase, a glycosyl transferase in plants, provides an alternative in enzymatic synthesis to the use of highly specific pyrophosphorylases. In an enzyme membrane reactor a continuous synthesis can be performed on preparative scale. [less ▲]

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See detailThe cognitive approach to familiar face processing in human subjects
Brédart, Serge ULg; Bruyer, R.

in Behavioural Processes (1994), 33(1-2), 213-232

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See detailQuelle stratégie pour le développement rural dans la structuration de l'espace régional?
Rondeux, Jacques ULg

in Annales de Gembloux (1994), 100(3-4), 93-107

L’espace rural comporte tellement de paramètres et de diversités et vit aujourd’hui tellement de mutations que le définir de manière précise est une gageure. On pourrait dire qu’il concerne un territoire ... [more ▼]

L’espace rural comporte tellement de paramètres et de diversités et vit aujourd’hui tellement de mutations que le définir de manière précise est une gageure. On pourrait dire qu’il concerne un territoire essentiellement agricole, à contours diffus, caractérisé par une grande diversité où l’homme y voit une source d’activités multiples, saisonnières ou complémentaires, de services gratuits et de ressources renouvelables : l’air, l’eau, le paysage. Ce n’est pas la ville, ce n’est pas le site industriel mais cela peut être les champs entre deux agglomérations, la forêt entre deux villes et surtout les grands espaces, le monde ouvert dans lequel on oublierait un peu vite que pour maintenir son originalité et valoriser ses atouts et donc se développer il doit se raccrocher à des villes, chacun tirant profit des spécificités et des potentialités de l’autre. Non au désert économique, non aux services systématiquement gratuits, non à l’absence de tissu urbain adapté ; voilà les conditions pour le maintien ou pour un oui à une agriculture revue et corrigée, à la qualité de la vie, à la beauté des paysages, aux espaces de liberté et de détente, en un mot à une nouvelle ruralité basée sur la solidarité. [less ▲]

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See detailOPTICAL MULTICHANNEL ANALYSIS OF PROTOCHLOROPHYLLIDE PHOTOTRANSFORMATION IN DETERGENT-SOLUBILIZED ETIOPLAST MEMBRANES OF WHEAT
Franck, Fabrice ULg; OUAZZANI, M. A.; DUJARDIN, E. et al

in Zeitschrift Fur Naturforschung C-A Journal Of Biosciences (1994), 49(1-2), 125-131

Extracts of wheat etioplast membranes obtained after treatment with 7 mM n-octyl-beta-D-glucopyranoside (OG), n-dodecyl-beta-D-maltoside (DM) or Triton X-100 contained the three spectral forms of Pchlide ... [more ▼]

Extracts of wheat etioplast membranes obtained after treatment with 7 mM n-octyl-beta-D-glucopyranoside (OG), n-dodecyl-beta-D-maltoside (DM) or Triton X-100 contained the three spectral forms of Pchlide (the photoactive Pchlide(638) and Pchlide(638) and the inactive Pchlide(650)) in various relative amounds. The OG extract had a Pchlide composition close to that of the intact membranes whereas the DM extract was enriched in Pchlide(638) and the Triton extract was enriched in Pchlide(630). Measurements of the kinetics of phototransformation and of time-resolved absorbance spectra during phototransformation in continuous Light shows that the inactive Pchlide(630) is in fact slowly transformed to Chlide, especially in the Triton extract where this form is more abundant. Addition of NADPH favours the phototransformation of Pchlide(630) and the slow regeneration of Pchlide(638) and Pchlide(650) from Pchlide(630) in darkness after illumination. No such regeneration was however observed in the Triton extract. NADPH had only slight effects on the Chlide shift towards shorter wavelengths after phototransformation in solubilized membranes. [less ▲]

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See detailPolylactide Microparticules Prepared by Double Emulsion/Evaporation Technique. I. Effect of Primary Emulsion Stability
Nihant; Schugens, Chantal; Grandfils, Christian ULg et al

in Pharmaceutical Research (1994), 11(10), 1479-1484

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound ... [more ▼]

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound is emulsified into an organic solution of the hydrophobic coating polymer; second, this primary water-in-oil (w/o) is dispersed in water with formation of a double water-oil-water emulsion (w/o/w), third, the organic solvent is removed with formation of solid microparticles. This paper focuses of the effect of primary emulsion stability on the morphology and properties of polylactide microparticles loaded with bovine serum albumin (BSA) used as model drug. [less ▲]

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See detailRelationship between alpha 2-adrenergic function and suicidal behavior in depressed patients.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Psychiatry Research (1994), 52(2), 115-23

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior involve serotonergic and, to a lesser extent, dopaminergic systems. Few data are available about the possible implication of the noradrenergic function. In the present study, we assessed the growth hormone response to clonidine, a selective alpha 2-adrenergic agonist, in 15 DSM-III-R major depressive inpatients with a history of suicide attempts, compared with 15 age- and gender-matched major depressive inpatients without a history of suicidal behavior. Mean (+/- SD) growth hormone peak responses to clonidine were significantly lower in the group of suicide attempters than in the control group: 2.93 +/- 3.01 ng/ml vs. 8.28 +/- 8.15 ng/ml. Therefore, these results suggest that a blunted growth hormone response to clonidine could be a biological correlate of suicidal behavior. [less ▲]

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See detailStructural Similarities Between Chaperone Molecules Of The Hsp60 And Hsp70 Families Deduced From Hydrophobic Cluster-Analysis
Callebaut, I.; Catelli, Mg.; Portetelle, Daniel ULg et al

in Febs Letters (1994), 342(3),

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See detailDémographie du martin pêcheur (Alcedo atthis): incidences climatiques sur le succès reproducteur
Libois, Roland ULg

in Gerfaut (Le) = Giervalk (De) (1994), 84

It is well known that the Kingfisher populations decrease dramatically after a sever winter. The recovery depends on the climatic conditions of the next reproductive seasons. In order to understand the ... [more ▼]

It is well known that the Kingfisher populations decrease dramatically after a sever winter. The recovery depends on the climatic conditions of the next reproductive seasons. In order to understand the mechanism involved in this climatic influence, the fate of more than 500 broods was studied between 1985 and 1993. The study area comprises the river Meuse from Vireux (F,08) downstreams to Huy (B Liège) and the lower part of its main tributaries. The first egg laying date was determined for each brood, eggs were counted, pulli ringed at nest and the adults controlled and ringed when possible. Our main conclusions are i : the beginning of the first clutch is correlated with the thermic conditions of March. ii : the clutches are not synchronised, even on a same watercourse. iii : the egg probuction and the hatching success don't show clear variations between years abd habitat types (river, ponds and small streams) or depending on the clutch rank. iv : the fledged young production depends on how much broods are raised by the different pairs. v : the probability a pair is attempting a thrid brood is function of how early the first clutch is layed, the age of the male (older males settle earlier and are more productive), the habitat quality and the weather conditions (rain, temperature) in May. [less ▲]

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See detailLa formation des agents de santé scolaire dans le cadre du programme "Je mange bien à l'école"
Vandoorne, Chantal ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), (3),

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See detailComparaison de plusieurs types d'unités d'échantillonnage dans la perspective d'un inventaire forestier régional.
Lecomte, H.; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Forestry Chronicle (1994), 70(3), 304-310

This study has been conducted in order to define the guidelines of a permanent forest inventory methodology that could applied to heterogenous forests located in the southern part of Belgium. Different ... [more ▼]

This study has been conducted in order to define the guidelines of a permanent forest inventory methodology that could applied to heterogenous forests located in the southern part of Belgium. Different types of sampling units generally used in European national inventories have been compared: fixed area sampling units (based upon 3 concentric circles), non fixed-area sampling units (Bitterlich plots using basal area factor of 2 and 4) and sampling units based upon a minimum number of trees (including nearly 15 measurable trees). In true conditions of application 259 sampling points have been selected according to a systematic rectangular grid (1.000 m x 500 m). Taking into account different criteria such as precision, cost and ease of use, the fixed-area sampling unit looks like the most adequate among the four types investigated. [less ▲]

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See detailTechniques moleculaires de detection et d'identification des agents phytopathogenes.
Lepoivre, Philippe ULg; Kummert, J.; Colinet, D. et al

in Cahiers Agricultures (1994), 3(4),

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See detailFunctional effects of a muscarinic receptor blockade during acute respiratory distress syndrome in double-muscled calves
Genicot, Bruno; Mouligneau, Frédéric; Close, Roland et al

in Veterinary Record : Journal of the British Veterinary Association (1994), 134(5), 110-113

Eighteen Belgian white and blue double-muscled calves suffering from the acute respiratory distress syndrome were studied. Fifteen of the calves inhaled ipratropium bromide (0.6 mg) four times a day for ... [more ▼]

Eighteen Belgian white and blue double-muscled calves suffering from the acute respiratory distress syndrome were studied. Fifteen of the calves inhaled ipratropium bromide (0.6 mg) four times a day for three to four days whereas the other three control calves inhaled sterile 0.9 per cent saline. All the animals were injected with ceftiofur sodium (1 mg/kg/day) for five days, the first injection being given one hour after the first inhalation of ipratropium bromide or saline. Arterial oxygen tension, alveolar arterial oxygen difference, carbon dioxide tension and arterial pH, respiratory and heart rates, oscillatory resistance and phase angle, measured by the mono-frequency forced oscillation technique, were recorded both before and one hour and 168 hours after the first inhalation. The measurement of oscillatory resistance and phase angle made it possible to resolve the impedance of the respiratory system into its real and imaginary components. The oscillatory compliance (Cosc) was determined from the imaginary component (Im). By one hour after the first inhalation of ipratropium bromide the oscillatory resistance was already significantly reduced and Im and Cosc had significantly increased, but the other parameters showed no significant improvement. However, between one hour and 168 hours after the first inhalation all the parameters reached physiological values. The control calves did not show any change. It was concluded that the pulmonary dysfunction associated with the acute respiratory distress syndrome in these calves was at least partly due to a severe bronchoconstriction. [less ▲]

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See detailFlow modeling in an underground gasifier at great depth by the Boundary-Element Method
MATHY, B.; PIRLOT, Pierre; Pirard, Jean-Paul ULg et al

in In Situ (1994), 18(4), 399-418

In order to simulate the cavity growth of an underground gasifier in thin seams at great depth, Wilks1 has developed an original model that solves the continuity equation in the horizontal plane with the ... [more ▼]

In order to simulate the cavity growth of an underground gasifier in thin seams at great depth, Wilks1 has developed an original model that solves the continuity equation in the horizontal plane with the hypothesis of radial fluid flow around the injection well. In the model presented here, the continuity equation in the horizontal plane has been taken into account, removing the limiting assumption on flow (radial direction) assumed by Wilks. The simultaneous solution of the continuity equation and the Darcy law has been carried out using the Boundary Element Method (BEM); this method is particularly suitable for solving problems where boundary conditions are of prime importance. The model enables the influences of the permeability of the medium and gasifier geometry to be demonstrated. [less ▲]

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See detailEctopie cervicale du coeur chez un veau
Gabriel, Annick ULg; Vandeputte, Sébastien ULg; Rollin, Frédéric ULg et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailCalcitropic effect of recombinant prolactins in Oreochromis mossambicus
Flik, G.; Rentier-Delrue, Françoise ULg; Wendelaar-Bonga, S. E.

in The American Physiological Society (1994)

Homologous recombinant tilapia prolactins 1 and 2 were tested for calcitropic activity in tilapia Oreochromis mossambicus. Injection of both PRLs induced hypercalcemia that resulted for an enhanced ... [more ▼]

Homologous recombinant tilapia prolactins 1 and 2 were tested for calcitropic activity in tilapia Oreochromis mossambicus. Injection of both PRLs induced hypercalcemia that resulted for an enhanced calcium influx via the gills and a decreased calcium efflux. Both PRLs increased the density of the Ca2+-transporting Ca2+-adenosinetriphosphatase in a plasma membrane preparation of the branchial epithelium. Dose-response studies demonstrated that the PRL-1 was roughly twofold more potent than PRL2 in inducing hypercalcemia, in enhacing basal levels of cortisol and in stimulating opercular ionocyte density. But both PRL were equipotent in stimulating the dermal mucocyte frequency. [less ▲]

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See detailSynthesis by sol-gel process and characterization of barium-titanate
LECLOUX, A. J.; KOCKLENBERG, Régine; MICHAUX, Bernard et al

in Annales de Chimie Science des Materiaux (1994), 19(2), 67-78

Barium titanate gels are prepared by sol-gel process from titanium isopropoxide and barium hydroxide in presence of methoxyethanol, methanol and water. These gels are dried under vacuum. The influence of ... [more ▼]

Barium titanate gels are prepared by sol-gel process from titanium isopropoxide and barium hydroxide in presence of methoxyethanol, methanol and water. These gels are dried under vacuum. The influence of the hydrolysis ratio, the temperature and the vacuum level during drying is discussed. [less ▲]

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See detailLe plan régional d'aménagement du territoire wallon
Delnoy, Michel ULg; Pâques, Michel ULg

in Aménagement - Environnement (1994), n° spécial

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See detailImproved Experimental and Theoretical Energy Levels of Neon I
Chang, E. S.; Schoenfeld, W. G.; Biémont, Emile ULg et al

in Physica Scripta (1994), 49

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See detailCompte rendu de L.G. Westerink, Stephanus of Athens. Commentary on Hippocrates'Aphorisms, Sections I-II, Berlin, 1985
Marganne, Marie-Hélène ULg

in Archives Internationales d'Histoire des Sciences (1994), 44

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See detailIntensities of the doublet-quadruplet intersystem transitions in C II and N III
Biémont, Emile ULg; Delahaye, F.; Zeippen, C. J.

in Journal of Physics : B Atomic Molecular & Optical Physics (1994), 27

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See detailLes dommages dus aux plans et leur indemnisation dans le cadre du CWATUP
Delnoy, Michel ULg

in Aménagement - Environnement (1994), 3

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See detailEnergy Levels in Ar II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Physical Review. A (1994), 49

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See detailChloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content
Bettendorff, Lucien ULg; Hennuy, Benoît ULg; De Clerck, Anne et al

in Brain Research (1994), 652(1), 157-160

Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates ... [more ▼]

Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates, increased TTP content correlates with increased 36Cl- uptake. A hyperbolic relationship was obtained with a K0.5 of 0.27 nmol TTP/mg protein. In crude mitochondrial fractions from the brains of animals previously treated with thiamine or sulbutiamine, a positive correlation between 36Cl- uptake and TTP content was found. These results, together with other results previously obtained with the patch-clamp technique, suggest that TTP is an activator of chloride channels having a large unit conductance. [less ▲]

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See detailEndoscopic management of ectopic pregnancy.
Donnez, Jacques; NISOLLE, Michelle ULg

in Bailliere's Clinical Obstetrics & Gynaecology (1994), 8(4), 707-2

The rationale for the conservative management of ectopic pregnancy is the preservation of reproductive potential. Removal of trophoblast through a linear incision (salpingotomy) can be easily performed by ... [more ▼]

The rationale for the conservative management of ectopic pregnancy is the preservation of reproductive potential. Removal of trophoblast through a linear incision (salpingotomy) can be easily performed by endoscopy. The injection of vasopressin into the broad ligament is required in less than 10% of cases and its routine use is not recommended because of the risk of severe side-effects. The techniques in cases of isthmic or cornual tubal pregnancy are also described. Other alternatives such as expectant management, methotrexate, RU 486 and prostaglandins have also recently been proposed. Although methotrexate therapy has been demonstrated to be effective in cases of unruptured tubal pregnancy, further studies are needed to determine whether or not this medical therapy is a safer option than laparoscopic surgery and to compare the subsequent intrauterine and recurrent ectopic pregnancy rates. Endoscopic salpingotomy is an efficacious procedure. Indeed, residual trophoblast is found in only 5% of cases after this surgical procedure. In these cases of persistent trophoblast, methotrexate is proposed as the medical approach of choice. Evaluation of the postoperative fertility after linear salpingotomy demonstrates an intrauterine pregnancy rate of 63% and a recurrent ectopic pregnancy rate of 8%. In conclusion, endoscopic management of tubal pregnancy is a safe and efficacious therapy. The contraindications are relative and depend essentially on the surgeon's experience. [less ▲]

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See detailBovine Leukemia Virus
Kettmann, Richard ULg; Burny, A.; Callebaut, I. et al

in The Retroviridae (1994)

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See detailL'analyse de la variance : une methode d'un autre âge ?
Claustriaux, Jean-Jacques ULg

in Biométrie-Praximétrie (1994), 34(2), 95-107

L'analyse de la variance est une ancienne méthode couramment utilisée pour le traitement statistique des données. Pour certains aspects, l'évolution de son utilisation pratique est présentée.

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See detailAssignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4
Marine, Jean-Christophe; Bellefroid, Eric J.; Bourguignon, Catherine et al

in Genomics (1994), 21(1), 285-6

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See detailSpectrum analysis of diaphragmatic global electromyograms in cattle, with special regard to appropriate strategy for detection of fatigue.
Desmecht, Daniel ULg; Linden, Annick ULg; Close, R. P. et al

in American Journal of Veterinary Research (1994), 55

Although the respiratory tract of healthy and diseased cattle has been intensively studied during the past few years, only a few attempts to detect dysfunctions of bovine inspiratory muscles have been ... [more ▼]

Although the respiratory tract of healthy and diseased cattle has been intensively studied during the past few years, only a few attempts to detect dysfunctions of bovine inspiratory muscles have been reported. Such technique would be useful in assessing the possibility of inspiratory muscle fatigue in the context of ventilatory failure. Fatigue in skeletal muscle is associated with characteristic changes in the electromyographic power spectrum. Power spectral analysis was therefore applied to cattle diaphragmatic electromyograms (EMGdi) to precisely determine the exact influence of motion and ECG artifacts, describe its basic frequency content, and extract a spectral index capable of providing an accurate warning of fatigue. The EMGdi was recorded via intramuscularly placed fishhook electrodes in 5 healthy young bulls during resting and stimulated respiration. The EMGdi and EGC signals were analyzed by use of power spectral density analysis after band-pass filtering (20 to 1,800 Hz). The EMGdi spectrum was concentrated in the band width 20 to 530 Hz. Electrode motion artifacts were absent, and it was always possible to find an electrode pair giving ECG-free EMGdi. Of the 12 power and frequency values used to quantitate the spectrum, the most stable was the centroid frequency. It was reproducible within and between calves and was only minimally altered by changing inspiratory load.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailLa rentabilité de l'activité hélicicole
Lebailly, Philippe ULg

in Agricontact (1994), (259 (mars)), 11-16

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See detailComparaison pratique de quelques méthodes d'analyse discriminante
Lazaar, N.; Palm, Rodolphe ULg

in Biométrie-Praximétrie (1994), 34

Dans cette étude, on compare les performances des trois méthodes d'analyse discriminante suivantes : analyse discriminante linéaire, analyse discriminante quadratique et analyse discriminante logistique ... [more ▼]

Dans cette étude, on compare les performances des trois méthodes d'analyse discriminante suivantes : analyse discriminante linéaire, analyse discriminante quadratique et analyse discriminante logistique. Les performances sont étudiées dans le cas de données réelles, en envisageant diverses transformations de variables destinées à modifier les conditions de normalité et d'égalité des variances entre populations. Aucune différence significative de performances entre méthodes n'a pu être mise en évidence au niveau de signification de 0,05. Par contre, les performances des trois méthodes diminuent quand les distributions des variables sont nettement non normales ou de variances très inégales. Différentes estimations des taux d'erreur ont également été comparées : resubstitutin, extraction-insertion et utilisation d'un échantillon-test. Les résultats ont montré que, par rapport à l'utilisation d'échantillons-tests, la méthode de resubstitution sous-estime le taux d'erreur. Cette sous-estimation est de l'ordre de 13 % du taux d'erreur réel. La méthode d'extraction-insertion donne par contre des résultats très semblables à la méthode utilisant un échantillon-test. [less ▲]

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See detailThe Pepinster formation in the Verviers synclinorium, between Pepinster and Eupen (Belgium). Structural and stratigraphical context
Hance, Luc ULg; Dejonghe, L; Fairon-Demaret, Muriel ULg et al

in Annales de la Société Géologique de Belgique (1994), 117

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See detailLaparoscopic adrenalectomy in pheochromocytoma and Cushing's syndrome. Reflections about two case reports.
Meurisse, Michel ULg; Joris, Jean ULg; Hamoir, Etienne ULg et al

in Acta Chirurgica Belgica (1994), 94(6), 301-6

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open ... [more ▼]

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open method. In combination with intraoperative infusion of nicardipine, a calcium-channel blocker, the laparoscopic removal of a pheochromocytoma was performed safely and under stable conditions. In case of Cushing's syndrome, the laparoscopic approach reduces the problems related to poor healing. In all cases of laparoscopic adrenalectomy, this approach could offer the clear advantages of smaller incisions, reduced postoperative pain and incisional discomfort as well as complications related to large and invasive procedure and finally allows quicker recovery. Moreover, conversion to open surgery remains always possible, if needed. [less ▲]

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See detailThe mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.
Wilkin, J M; Dubus, Alice ULg; Joris, Bernard ULg et al

in Biochemical Journal (1994), 301 ( Pt 2)

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the ... [more ▼]

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the active-site cavity. Thr299 corresponds to the second residue of the Lys-Thr(Ser)-Gly triad, highly conserved in active-site beta-lactamases and penicillin-binding proteins (PBPs). Modification of Thr301 resulted only in minor alterations of the catalytic and penicillin-binding properties of the enzyme. No selective decrease of the rate of acylation was observed for any particular class of compounds. By contrast, the loss of the hydroxy group of the residue in position 299 yielded a seriously impaired enzyme. The rates of inactivation by penicillins were decreased 30-50-fold, whereas the reactions with cephalosporins were even more affected. The efficiency of hydrolysis against the peptide substrate was also seriously decreased. More surprisingly, the mutant was completely unable to catalyse transpeptidation reactions. The conservation of an hydroxylated residue in this position in PBPs is thus easily explained by these results. [less ▲]

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See detailMétaux lourds et isotopes stables du carbone dans la matière particulaire: distribution sur le plateau continental nord-ouest européen
Dauby, Patrick ULg; Mosora, Fiorentina; Frankignoulle, Michel et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63

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See detailNuclear magnetic resonance spectroscopy : insights into experimental septic shock
GILLES, R; CARLIER, PG; D'Orio, Vincenzo ULg

in Intensive Care Medicine (1994)

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See detailCommon Prevalence Of Alanine And Glycine In Mobile Reactive Center Loops Of Serpins And Viral Fusion Peptides - Do Prions Possess A Fusion Peptide
Callebaut, I.; Tasso, A.; Brasseur, Robert ULg et al

in Journal of Computer-Aided Molecular Design (1994), 8(2),

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by ... [more ▼]

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by high levels of glycine. These two small residues, which are not simultaneously abundant in stable helices (standard or transmembrane), probably play an important role in mobility. Threonine and valine (also relatively small amino acids) are also abundant in these two kinds of peptides. Moreover, the known 3D structures of an uncleaved serpin reactive centre and a fusion peptide are strikingly similar. Such sequences possess many small residues and are found in several signal peptides and in PrP, a protein associated with spongiform encephalopathies and resembling virus envelope proteins. These properties may be related to the infection mechanisms of these diseases. [less ▲]

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See detailThe functional proof of the diaphragm's specific type of motor innervation in Ongulae
Desmecht, Daniel ULg; Linden, Annick ULg; Leroy, Pascal ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailThiamine in Excitable Tissues: Reflections on a Non-Cofactor Role
Bettendorff, Lucien ULg

in Metabolic Brain Disease (1994), 9(3), 183-209

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See detailGénétique moléculaire des récepteurs olfactifs
Parmentier, M.; Vanderhaeghen, P.; Schurmans, Stéphane ULg et al

in Medecine Sciences : M/S (1994), 10

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des ... [more ▼]

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des récepteurs à sept passages transmembranaires couplés, par l'intermédiaire de protéines G, à l'activation de l'adénylyl cyclase et de la phospholipase C. La grande diversité des récepteurs olfactifs réside surtout dans les domaines transmembranaires III, IV, V et VI, qui portent les sites de liaison des ligands, les molécules odorantes, et répond sans doute à la diversité des ligands [less ▲]

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See detailNatural-Convection Above Line Heat-Sources In Greenhouse Canopies
Aubinet, Marc ULg; Deltour, Jules

in International Journal of Heat and Mass Transfer (1994), 37(12),

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See detailEffect of the emulsion stability on the morphology and porosity of semicrystalline poly-L-lactide micriparticles prepared by w/o/w double emulsion-evaporation
Schugens, Ch; Laruelle, N; Nihant, N et al

in Journal of Controlled Release (1994), 32

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See detailA thyroid hormone receptor-dependent glucocorticoid induction.
Leers, Joerg; Steiner, Christoff; Renkawitz, Rainer et al

in Molecular Endocrinology (Baltimore, Md.) (1994), 8(4), 440-7

Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to ... [more ▼]

Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to the discovery of synergism between a thyroid hormone receptor-binding site and a cryptic glucocorticoid-responsive element. Glucocorticoid responsiveness could only be detected in the presence of thyroid hormone and its receptor. This synergism requires the glucocorticoid receptor (GR) DNA-binding domain and is mediated by the transactivation domains. We found that synergism also occurs when the thyroid hormone receptor is replaced by the retinoic acid receptor or the GR is replaced by the progesterone receptor. Synergism is qualitatively independent of the type of thyroid hormone receptor-binding site and promoter. In several combinations of promoter and response elements, including a retinoic acid response element, T3 induction was only seen in the presence of the cryptic glucocorticoid-responsive element, GR, and glucocorticoids. [less ▲]

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See detailA propos d'un cas de kératite a Mycobacterium chelonae
Duchesne, Bernard ULg; Marechal-Courtois; Melin, Pierrette ULg

in Bulletin de la Société Belge d'Ophtalmologie (1994), 254

The authors presents one case of primitive corneal mycobacterium keratitis after corneal graft. This rare form of keratitis is analysed in the field of mycobacterial infections who's nowadays more ... [more ▼]

The authors presents one case of primitive corneal mycobacterium keratitis after corneal graft. This rare form of keratitis is analysed in the field of mycobacterial infections who's nowadays more developed in our industrialised countries. The description of the case point out the multiresistance of this mycobacterium and describe the different treatments. [less ▲]

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See detailTwo silencing sub-domains of v-erbA synergize with each other, but not with RXR.
Martin, Bernd; Renkawitz, Rainer; Muller, Marc ULg

in Nucleic Acids Research (1994), 22(23), 4898-905

The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) induce gene expression in the presence of specific ligand and repress transcription in the absence of hormone. This repression is ... [more ▼]

The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) induce gene expression in the presence of specific ligand and repress transcription in the absence of hormone. This repression is mediated by an active silencing mechanism rather then by interference with DNA binding activators. V-erbA, a variant form of TR which is unable to bind hormone, represents a constitutive repressor. Here we show, using fusion proteins with the GAL4 DNA binding domain, that the minimal silencing domain of v-erbA extends from amino acids 389 to 632 and that internal deletions within this domain retain at least some repression function. Co-transfection experiments of different deletion mutants indicate that the silencing domain is composed of at least two sub-domains which are non-functional when tested individually. When combined in a heterodimeric complex, they synergize such that silencing activity is regained. In contrast to the retinoic acid receptor the retinoid X receptor does not contain a silencing domain. In addition it is unable to cooperate with the repression function of TR or v-erbA in a heterodimer. [less ▲]

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See detailThe Perturbed Tikhonov's Algorithm and Some of its Applications
Tossings, Patricia ULg

in RAIRO : Modélisation Mathématique et Analyse Numérique (Mathematical Modelling and Numerical Analysis) (1994), 28(2), 189-221

The proximal point algorithm has known these last years many developments connected with the expansion of the variational convergence theory. Motivated by this fact and inspired by the work of A. Tikhonov ... [more ▼]

The proximal point algorithm has known these last years many developments connected with the expansion of the variational convergence theory. Motivated by this fact and inspired by the work of A. Tikhonov and V. Arsénine in the context of convex optimization, we present a new algorithm for searching a zero of a maximal monotone operator on a real Hilbert space. We study the perturbed version of this algorithm and establish a critical comparison with the perturbed proximal point algorithm. We apply this new algorithm to convex optimization and to variational inclusions or, more particularly, to variational inequalities. [less ▲]

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See detailLes écrans de la transparence. Essai de définition sémio-pragmatique du discours télévisuel
Badir, Sémir ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994), 70-71-72

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See detailEffects of immunization against somatostatin on growth performances and growth hormone, insulin-like growth factor I and insulin plasma levels in young animals
Renaville, Robert ULg; Fernadez, J. J.; Sneyers, Myriam et al

in Zootecnica e Nutrizione Animale (1994), 20

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See detailPeritoneal endometriosis: two-dimensional and three-dimensional evaluation of typical and subtle lesions.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise

in Annals of the New York Academy of Sciences (1994), 734

Endometriosis most commonly affects the pelvic peritoneum close to the ovaries, including the uterosacral ligaments, the ovarian fossa peritoneum, and the perito- neum of the cul-de-sac. The increased ... [more ▼]

Endometriosis most commonly affects the pelvic peritoneum close to the ovaries, including the uterosacral ligaments, the ovarian fossa peritoneum, and the perito- neum of the cul-de-sac. The increased diagnosis of endometriosis at laparoscopy can be explained by the increased experience and ability of the surgeon to detect such subtle lesions. The greatest change has been in the case of “subtle” lesions, which increased from 15% in 1986 to 65% in 1988. The diagnosis of peritoneal endometriosis at the time of laparoscopy is often made by the observation of typically puckered black or bluish lesions. There are, in addition, numerous subtle appearances of peritoneal endometriosis. These lesions, frequently nonpigmented, were diagnosed as endometriosis following confirmation by biopsy by Jansen and Russell in 1986. [less ▲]

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See detailPreliminary of observations on oribatid mites of riparian soils in Uruguay
Sarasola, M.; Vera, H.; Wauthy, G. et al

in Bulletin et Annales de la Société Royale Belge d’Entomologie = Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1994), 130

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See detailLe Marquis et les castrats. Note sur un tabou sadien
Durand, Pascal ULg

in Art&Fact (1994), 13

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See detailThe experience of the CHU Liege with conservative surgery in the management of upper urinary tract tumors.
Bouffioux, Christian ULg; Andrianne, Robert ULg; Bonnet, Pierre ULg et al

in Acta Urologica Belgica (1994), 62(4), 39-43

A review of 20 cases of conservative surgery for urothelial tumors of the upper tract is presented. The morbidity is limited; the recurrence rate is around 15% in the ipsilateral urinary tract with a mean ... [more ▼]

A review of 20 cases of conservative surgery for urothelial tumors of the upper tract is presented. The morbidity is limited; the recurrence rate is around 15% in the ipsilateral urinary tract with a mean follow up of 41 months. Conservative surgery does not seem to carry a higher fatal risk as compared to more radical surgery. It has indications in some cases which are defined. [less ▲]

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See detailAspects of the ecology of the wood-inhabiting fungi of Laing Island (Papua New Guinea)
Castillo Cabello, Gabriel ULg; Demoulin, Vincent ULg

in Belgian Journal of Botany (1994)

Dans le cadre d'une étude sur l'écologie des champignons lignicoles de l'île de Laing (Papouasie Nouvelle-Guinée), les espèces les plus fréquemment rencontrées (en particulier: Schizophyllum commune ... [more ▼]

Dans le cadre d'une étude sur l'écologie des champignons lignicoles de l'île de Laing (Papouasie Nouvelle-Guinée), les espèces les plus fréquemment rencontrées (en particulier: Schizophyllum commune, Daldinia eschscholzii et Trametes scabrosa) ont été cartographiées. Les résultats montrent qu'il existe une bonne corrélation entre le type de répartition des champignons et le degré de couverture végétale. In the framework of a study of the ecology of wood-inhabiting fungi on Laing Island (Papua New-Guinea), the most frequently occurring species (namely Schizophyllum commune, Daldinia eschscholzii and Trametes scabrosa) were mapped. The results show a good correlation between the distribution of the fungi and the degree of vegetation cover. [less ▲]

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See detailKibaran A-type granitoids and mafic rocks generated by two mantle sources in a late orogenic setting (Burundi)
Tack, Luc; Liégeois, Jean-Paul ULg; Deblond, André et al

in Precambrian Research (1994), 68

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See detailExperimental Models of Inflammatory Bowel Disease
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1994), 57(5-6, Sep-Dec), 306-9

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced ... [more ▼]

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced models. Spontaneous models are infectious, genetic or of unknown etiology. Induced models are infectious, immune-mediated, chemical or genetic. All these models share some characteristics with IBD. In general, they are characterized by a chronic inflammation of the gut, and often, this inflammation appears secondary to mucosal abnormalities leading to an abnormal immune and inflammatory response toward luminal material. The most interesting models are thus those that share not only clinical and pathological characteristics with IBD, but also early mucosal abnormalities. From that point of view, the nonsteroidal anti-inflammatory drug (NSAID) enteropathy is probably one of the most interesting model for Crohn's disease (CD). In effect, this model shares an early modification with CD, that is increased intestinal permeability. In animals NSAID enteropathy, the increased intestinal permeability appears early after NSAID administration and is followed by inflammatory lesions. These lesions seem to be secondary to the increased permeability and depend on intraluminal materials, such as alimentary antigens or bacterial fragments. A possible link between the increased permeability and the inflammatory lesions could be an abnormal immune and inflammatory response toward the intraluminal materials. If the increased intestinal permeability in CD was confirmed, the same mechanisms could be implicated in its pathophysiology. [less ▲]

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See detailQue peut-on attendre des marqueurs immunohistochimiques du mélanome?
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1994), 13

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See detailDu « bon usage » de la notion de syncrétisme
Pirenne-Delforge, Vinciane ULg; Motte, André ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1994), 7

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See detailDe réels progrès ont-ils été faits dans le traitement de l'ostéoporose ?
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Franchimont, P

in Les Nouvelles de Rhumatologie (1994), 4

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See detailA Consistent next-to-leading order QCD calculation of hadronic diffractive scattering
Cudell, Jean-René ULg; Nguyen, Bao

in Nuclear Physics B (1994), 420

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See detailCharacterization of a single strong tissue-specific enhancer downstream from the three human genes encoding placental lactogen
Jacquemin, Patrick; Oury, Cécile ULg; Peers, Bernard ULg et al

in Molecular & Cellular Biology (1994), 14(1), 93-103

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3 ... [more ▼]

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3'. So far, a single placenta-specific enhancer has been identified in the locus, 2 kb downstream from the hCS-B gene, and shown to comprise one in vitro binding site for a nuclear protein. We here provide evidence that the hCS-B enhancer is more complex: (i) protection against DNase I digestion in the 3' flanking region of the hCS-B gene reveals four binding sites (DF-1, DF-2, DF-3, and DF-4) for nuclear proteins from either placental or HeLa cells, and (ii) placenta-specific enhancer activity can be fully exerted in transient expression experiments by a 126-bp fragment comprising the DF-3 and DF-4 protein-binding sites. By dissecting this region, we show that enhancer activity is mediated by a synergy between DF-3 and DF-4. Competitions with various oligonucleotides in footprinting and gel retardation experiments indicate that the same protein or set of proteins, different in HeLa and placenta cell nuclei, interacts with sites DF-2, DF-3, and DF-4. We also studied the regions of the hCS-L and hCS-A genes which are highly similar to the hCS-B enhancer. Although they each present the same four protein-binding sites, they exhibit only minor enhancer activity. [less ▲]

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See detailVimentinoma, an Unusual Neoplasm of the Skin
Hermanns-Le, Trinh ULg; Nikkels, Arjen ULg; Ammar et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1994), 189(1), 84-86

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and ... [more ▼]

We report an unusual benign neoplasm that developed in a child. Tumoral cells were filled with vimentin intermediate filaments. No other features of differentiation were found by immunohistochemistry and electron microscopy. 'Vimentinoma' appears to be the most appropriate name for this neoplasm. [less ▲]

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See detailFactors influencing between-laboratory variability of C-reactive protein results as evidenced by the Belgian External Quality Assessement (EQA) Scheme
Devleeschouwer, N.; Libeer, J. C.; Chapelle, Jean-Paul ULg et al

in Scandinavian Journal of Clinical & Laboratory Investigation (1994), 54(6), 435-40

Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using ... [more ▼]

Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using homogeneous systems with several calibration points generally achieved better performance. Working temperatures influenced the results to a lesser extent. The present study stresses the importance for EQA organizers to collect more detailed information about CRP analytical methods used by the participants. It also suggests that manufacturers should be more involved in the management of quality, in particular by striving for standardization of the material (kit and calibrator) they produce for CRP assay. [less ▲]

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See detailAsthme et hyperréactivité bronchique non spécifique
Louis, Renaud ULg; Kayembe, J. M.; Radermecker, Maurice ULg

in Acta Clinica Belgica (1994), 49(3-4), 148-57

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes ... [more ▼]

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes modifying the functional status of airway smooth muscle as well as the structure of the bronchial wall. The responsiveness toward a direct constricting pharmacological agent is poorly correlated to the one toward an indirect constricting agent or a physical stimulus which cause airway obstruction through a more complex mechanism. Transversal studies show a relationship between the severity of asthma and the level of methacholine airway responsiveness. Long term treatment with corticoids can reduce the bronchial hyperresponsiveness of asthmatics. [less ▲]

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See detailMéléagre dans les Argonautiques
Renaud, Jean-Michel ULg

in Uranie : Mythes et Littératures (1994), 4

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See detailExpected returns and volatility in european stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza

in International Review of Economics and Finance (1994), 3(1), 45-56

The type of return generating process we test here on three European markets are GARCH and AR-GARCH in mean models with innovations that have either normal or student-t densities with time dependant ... [more ▼]

The type of return generating process we test here on three European markets are GARCH and AR-GARCH in mean models with innovations that have either normal or student-t densities with time dependant variances. These models are appealing in that they estimate time varying volatility in disturbances of stock returns series and ex-ante relationship between stock returns and volatility. Our results indicate that there is no statistically significant coefficient estimates for the volatility in the mean equation and that variance might not be appropriate as a measure of risk. Other proxies for risk should then be searched for. [less ▲]

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See detailChoix d'une nouvelle variete pour les zones cotonnieres meridionales du Zaire. Resultats des essais varietaux preliminaires.
Mergeai, Guy ULg; Ndungo, V.; Folo, A. et al

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(4),

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See detailThe phytoplankton community of the river Meuse, Belgium: seasonal dynamics (year 1992) and the possible incidence of zooplankton grazing
Gosselain, Véronique ULg; Descy, Jean-Pierre; Everbecq, Etienne ULg

in Hydrobiologia (1994), 289

Qualitative and quantitative aspects of the phytoplankton of the river Meuse were studied during 1992 at a point 537 km from the source. The phytoplankton was dominated by diatoms and green algae. The ... [more ▼]

Qualitative and quantitative aspects of the phytoplankton of the river Meuse were studied during 1992 at a point 537 km from the source. The phytoplankton was dominated by diatoms and green algae. The factors regulating the phytoplankton groxth were clearly physical variables : discharge, temperature and irradiance. [less ▲]

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See detailA TEF-1 binding motif that interacts with a placental protein is important for the transcriptional activity of the hCS-B enhancer
Jacquemin, P.; Oury, Cécile ULg; Belayew, A. et al

in DNA & Cell Biology (1994), 13(10), 1037-45

The transcriptional activity of the human placental lactogen genes (choriosomatomammotropic hormone, hCS) is controlled by tissue-specific enhancers located 4 kb downstream from their respective origins ... [more ▼]

The transcriptional activity of the human placental lactogen genes (choriosomatomammotropic hormone, hCS) is controlled by tissue-specific enhancers located 4 kb downstream from their respective origins of transcription. The hCS-B enhancer is the strongest; its activity is mediated by synergism between two protein-binding sites (DF-3 and DF-4). The DF-4 site possesses a potential binding sequence for TEF-1, a known transcription factor. In this paper, we show by electrophoretic mobility-shift assays and antibody supershift experiments that TEF-1 does not bind to site DF-4. Mutations in the TEF-1-like binding motif of site DF-4 prevent formation of the DNA-protein complex, called complex f, in the presence of placental JEG-3 cell extracts. When HeLa cell extracts are used, another complex (complex c) is also affected. In transient expression experiments, TKCAT constructs linked to this mutated DF-4 site exhibit greatly reduced transcriptional activity when introduced into JEG-3 cells. Some cell lines contain both protein c and protein f (the proteins forming complexes c and f); when transfected, these lines display reduced DF-4-driven activity, suggesting that the two proteins could compete for the same DF-4 sequence. We conclude that protein f is important for the placenta-specific activity of the hCS-B enhancer. By UV cross-linking, we show that protein f is actually three polypeptides ranging in size from about 12 to 21 kD. [less ▲]

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See detailLa crise suicidaire de l'adolescent, un appel à la vie
Malchair, Alain ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 2

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See detailMonofrequency Forced Oscillation Technique for the Investigation of Pulmonary Function in Calves: In Vitro and in Vivo Studies
Close, Roland; Reinhold, Petra; Lekeux, Pierre ULg

in Research in Veterinary Science (1994), 56(3), 363-372

Parameters derived from the non-invasive and simple monofrequency forced oscillation technique were compared with classical parameters of ventilatory mechanics in order to assess its usefulness for the ... [more ▼]

Parameters derived from the non-invasive and simple monofrequency forced oscillation technique were compared with classical parameters of ventilatory mechanics in order to assess its usefulness for the investigation of pulmonary function in calves. To facilitate this comparison, theoretical derivations were coupled with in vitro measurements, using an artificial lung model, and with in vivo studies. These studies compared the oscillatory resistance parameters (Ros and Re) and the respiratory system compliance (Crs) against the classical pulmonary resistance (RL) and the dynamic compliance (Cdyn), respectively. Ros and Re were highly correlated (r > or = 0.87) with RL and the comparison between Crs and Cdyn gave a similarly high correlation (r > or = 0.88). Given its simplicity, its correspondence with classical parameters and its rapidity and reproducibility, monofrequency forced oscillation technique seems well suited for the investigation of pulmonary function under field conditions. [less ▲]

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See detailThe 4s-4p Transitions in Neutral Phosphorus
Biémont, Emile ULg; Martin, F.; Quinet, Pascal ULg et al

in Astronomy and Astrophysics (1994), 283

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See detailApprendre, ou se mettre en projet ? Réflexions au départ d'une expérience de pédagogie du projet en classe du secondaire
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1994), 44e année(n°1), 5-17

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See detailAirway occlusion pressure and diaphragm global electromyograph analysis for evaluation of inspiratory muscle drive and neuromechanical coupling in cattle
Desmecht, Daniel ULg; Linden, Annick ULg; Rollin, Frédéric ULg et al

in American Journal of Veterinary Research (1994), 55

Although healthy and diseased bovine respiratory tracts have been intensively studied during the last years, to the authors' knowledge, there have been no attempts to objectively examine the inspiratory ... [more ▼]

Although healthy and diseased bovine respiratory tracts have been intensively studied during the last years, to the authors' knowledge, there have been no attempts to objectively examine the inspiratory drive from the brain to the nerves and muscles and its transformation in pressure. Such technique would be useful in assessing the possibility of altered ventilatory drive or inspiratory muscle fatigue in the context of an animal with ventilatory failure. The relation among ventilation, airway opening occlusion pressure generated 100 milliseconds after onset of inspiration (Pawo100ms) and 6 indexes describing diaphragmatic electromyographic activity (EMGdi) recorded via implanted fishhooks was evaluated during free and impeded CO2 rebreathing in 6 young bulls. The best significant linear correlations (r > 0.8) with inspiratory center afferent stimulation, as judged by end-tidal CO2 concentration in expired air, were found for Pawo100ms, peak moving time average or variance EMGdi, and mean integrated EMGdi, whatever had been the respiratory impedance. However, with an inspiratory load, Pawo100ms responses systematically had greater increase for a given change in the driving EMGdi, implying dependence of the former not only on neural input, but also on configurational factors that determine inspiratory muscle excitation-pressure generation couplings. The reproducibility of EMGdi absolute values and changes was satisfactory up to 10 hours, but could not be repeated from one day to the other. It was concluded that, provided the constancy of the electrical coupling of the recording system to the tissue being studied is ensured, specific EMGdi and Pawo100ms values correlate reliably with amount of CO2 during free and loaded breathing.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailDe réels progrès ont-ils été faits dans le traitement de l'ostéoporose ?
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Franchimont, P

in Medisearch (1994), 81

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See detailHistorical seismicity of the lower Rhine and Meuse valleys from 600 to 1525 : a new critical review
Alexandre, Pierre ULg

in Netherlands Journal of Geosciences - Geologie en Mijnbouw (1994), 173

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See detailSuccessful removal of an intramedullary spinal paraganglioma from a dog
Poncelet, Luc; Snaps, Frédéric ULg; Jacobovitz, D. et al

in Journal of the American Animal Hospital Association (1994), 30(3), 213-216

An 11-year-old, mixed-breed dog suffering progressive asymmetric hind limb ataxia was diagnosed as having spinal cord compression at the L1 spinal level. An intramedullary, encapsulated tumor was ... [more ▼]

An 11-year-old, mixed-breed dog suffering progressive asymmetric hind limb ataxia was diagnosed as having spinal cord compression at the L1 spinal level. An intramedullary, encapsulated tumor was surgically removed. Tumor microscopic features, positive neuron-specific enolase (NSE) immunostaining, and Grimelius staining led to the diagnosis of paraganglioma. The dog was free from any neuroloaic signs 12 days after surgery. [less ▲]

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See detailLes films Lumière : médiation symbolique et médiatisation
Servais, Christine ULg

in European Journal for Semiotic Studies = Revue Européenne d'Etudes Sémiotiques = Europäische Zeitschrift für Semiotische Studien (1994), 6(3-4), 505-538

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See detailFavoriser la reproduction des poissons à Lanaye.
Poncin, Pascal ULg; Keulen, C.

in Pêcheur Belge (Le) (1994), 6

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See detailStatistical properties of daily returns : evidence from european stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza

in Journal of Business Finance and Accounting (1994), 21(2), 271-282

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See detailL'autisme et la pensée du temps
Gauthier, Jean-Marie ULg

in Recherches du centre international de psychosomatique (1994), 1

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See detailRecherches paléolithiques et mésolithiques en Belgique, 1993: le Trou Magrite, Huccorgne et l'Abri du Pape
Noiret, Pierre ULg; Otte, Marcel ULg; Straus, Lawrence et al

in Notae Praehistoricae (1994), 13

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See detailMachine learning, neural networks and statistical pattern recognition for voltage security: a comparative study
Wehenkel, Louis ULg; Van Cutsem, Thierry ULg; Pavella, Mania ULg et al

in International Journal of Intelligent Systems (1994), 2

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See detailCompte rendu de The Brunner Collection of Medieval Art
George, Philippe ULg

in Moyen Age (Le) (1994)

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See detailTherapy for obesity--today and tomorrow.
Scheen, André ULg; Desaive, Claude ULg; Lefebvre, Pierre ULg

in Bailliere's Clinical Endocrinology and Metabolism (1994), 8(3), 705-27

Obesity poses a serious health hazard and its treatment is often disappointing. Besides conservative methods, the place of pharmacotherapy, very-low-calorie diets, and even, in selected cases, mechanical ... [more ▼]

Obesity poses a serious health hazard and its treatment is often disappointing. Besides conservative methods, the place of pharmacotherapy, very-low-calorie diets, and even, in selected cases, mechanical means or surgery can be considered. Effective drug treatment for obesity must reduce energy intake, or increase energy expenditure, or increase energy losses in faeces. All these possibilities have potential activities but also serious limitations. Current pharmacotherapy essentially uses anorectic drugs and the other approaches, although promising, are still under investigation. Of the anorectic compounds currently available, serotoninergic agents, like dexfenfluramine and fluoxetine, appear to have the most suitable pharmacological profile. Very-low-calorie diets could help in the short-term but should be associated with other approaches to increase the rate of long-term success. They must be well-balanced as macronutrients and micronutrients are concerned, be prescribed in well-selected patients under careful medical supervision, and not be followed longer than a few weeks. Surgery can provide palliation for severe obesity when all medical approaches have failed. It may consist in decreasing food intake (gastric procedures), affecting calorie absorption (intestinal shunting, biliopancreatic bypass), or removing localized excess fat (lipectomy, liposuction). Gastric reduction operations are safe and effective provided they are performed by experienced surgeons in well-selected patients. They can be considered now as the best option for a minority of patients with morbid and refractory obesity. Finally, in very selected patients, mechanical means (such as the waist cord) may also help losing weight and/or avoiding weight regain. Even if all these therapeutic approaches can be helpful, at least in some obese individuals, they also have important limitations so that prevention remains up to now the 'treatment' of choice for obesity. [less ▲]

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See detailNew Energy Levels in Ne II deduced from FTS spectra in the Infrared Region (1800-9000 cm-1)
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg

in Physica Scripta (1994), 49

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See detailMultiple muscarinic receptor subtypes mediating pulmonary oedema in the rabbit.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Pulmonary Pharmacology (1994), 7(3), 185-93

The effects of various muscarinic antagonists on acetylcholine (ACh)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. ACh induced a dose-dependent increase in the capillary ... [more ▼]

The effects of various muscarinic antagonists on acetylcholine (ACh)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. ACh induced a dose-dependent increase in the capillary filtration coefficient (Kf,c). This effect has been previously related to the activation of the capsaicin-sensitive nerve fibres and the release of substance P. Atropine, pirenzepine (M1-selective antagonist) and 4-DAMP (M3-selective antagonist) altered this response, producing a dose-dependent shift to the right of the ACh concentration-Kf,c response curve. By contrast, the M2-selective antagonist AFDX-116 shifted the ACh concentration-response curve to the left. Atropine, pirenzepine and 4-DAMP also significantly reduced the capsaicin-induced increase in the Kf,c, while AFDX-116 enhanced it. We conclude that multiple muscarinic receptor subtypes are present in the rabbit lung, located on the C-fibres, and are involved in the ACh-induced pulmonary oedema. M1 and M3 receptors seem to stimulate the release of neuropeptides from C-fibres, whereas M2 receptors have an inhibitory effect on these fibers. [less ▲]

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