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See detailThe effect of processing on inflammatory markers in induced sputum.
Louis, Renaud ULg; Shute, J.; Goldring, K. et al

in European Respiratory Journal (1999), 13(3), 660-7

The effects of the mucolytic agent, dithioerythritol (DTE), and the temperature at which sputum processing is conducted on cellular and biochemical markers in induced sputum was assessed. Samples from ... [more ▼]

The effects of the mucolytic agent, dithioerythritol (DTE), and the temperature at which sputum processing is conducted on cellular and biochemical markers in induced sputum was assessed. Samples from healthy and atopic asthmatic subjects were treated with either DTE or phosphate-buffered saline (PBS) at 22 or 37 degrees C and compared for cell counts and concentrations of histamine, tryptase, eosinophil cationic protein (ECP), free interleukin (IL)-8, immunoglobulin (Ig)A, IL-8/IgA complexes and secretory component (SC). In addition, the influence of DTE on in vitro mediator release from blood eosinophils, basophils and bronchoalveolar lavage (BAL) mast cells was studied. Processing with DTE improved cytospin quality and increased the cell yield and measurable ECP, tryptase, IgA and SC, but reduced levels of histamine in PBS-treated samples and had no effect on IL-8. Cell counts or mediator levels were similar when sputum was processed at 22 or 37 degrees C, even though DTE induced blood basophils and BAL mast cells to release histamine at 37 degrees C. In spiking experiments, recovery of added ECP, tryptase, total IL-8 and histamine from sputum was similar in DTE- and PBS-processed sputum, but reduced for free IL-8 in PBS-treated samples. In conclusion, dithioerythritol improves cell and mediator recovery without causing cell activation when sputum processing is conducted at room temperature. The extent of recovery depends on the mediator studied. [less ▲]

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See detailCLF Based designs with robustness to dynamic input uncertainties
Jankovic, Mrdjan; Sepulchre, Rodolphe ULg; Kokotovic, Petar

in Systems & Control Letters (1999), 37

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See detailPrivilège du bailleur, action en distraction et compétence du juge des saisies: questions croisées, note sous Liège (7e ch.), 25 nov. 1997
Georges, Frédéric ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detailAvantages des nouveaux traitements contre les puces et les tiques
Delaunois, A.; Gustin, Pascal ULg

in Pharma-Sphère (1999), 30

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See detailExploration isocinétique : analyse des paramètres chiffrés
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Annales de Réadaptation et de Médecine Physique (1999), 42

Introduction : Dans le domaine de l'évaluation de la fonction musculaire, l'isocinétisme permet la quantification de paramètres définissant la qualité de force. Méthode-Objectif : Il s'agit cependant d ... [more ▼]

Introduction : Dans le domaine de l'évaluation de la fonction musculaire, l'isocinétisme permet la quantification de paramètres définissant la qualité de force. Méthode-Objectif : Il s'agit cependant d'optimaliser l'interprétation du bilan isocinétique. Le choix des paramètres les plus représentatifs exige une étude de reproductibilité. Résultats : Lors d'efforts concentriques et excentriques des muscles fléchisseurs et extenseurs du genou, le moment de force maximum répond aux critères qualitatifs souhaités (coefficients de variation faibles); les paramètres de puissance et de travail ne semblent pas apporter d'information complémentaire discriminante en pratique courante. Conclusion: Les auteurs proposent des valeurs de référence et fixent des "limites" précises permettant de distinguer le normal du pathologique, particulièrement pour les paramètres différence bilatérale et rapport agonistes/antagonistes. [less ▲]

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See detailAn MRI study of the effect of treadmill training on bone morphology of the central and third tarsal bones of young Thoroughbred horses
Whitton, R. C.; Murray, R. C.; Buckley, C. et al

in Equine Veterinary Journal. Supplement (1999), 30

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to ... [more ▼]

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to determine whether training influenced modelling of the third and central tarsal bones in Thoroughbred horses. Twelve untrained Thoroughbred horses were divided into 2 groups. Group 1 underwent a 19 week progressive training regimen on a high speed treadmill. Group 2 were walked for 40 min daily. Images of left tarsi were obtained by magnetic resonance imaging (MRI) with a 0.5 Tesla superconducting magnet using a spin echo sequence. Sagittal and oblique sagittal slices were made perpendicular to the articular surfaces of the intertarsal joints and were analysed using image analysis software to measure the proportion of dense subchondral bone in the dorsal facet of each bone. Mean +/- s.d. percentage area of dense subchondral bone in the dorsal facet of the central tarsal bone in Group 1 was 47 +/- 8 medially, 46 +/- 4 sagitally and 50 +/- 11 dorsolaterally, whereas in Group 2 it was 39 +/- 16 medially, 43 +/- 8 sagitally and 53 +/- 7 dorsolaterally. For the third tarsal bone mean +/- s.d. percentage area of dense subchondral bone in Group 1 was 32 +/- 10 medially, 39 +/- 11 sagitally and 44 +/- 8 dorsolaterally, whereas in Group 2 it was 28 +/- 8 medially, 37 +/- 6 sagitally and 41 +/- 9 dorsolaterally. There was no significant difference in percentage area of dense subchondral bone between the trained and untrained horses. An effect of treadmill training of Thoroughbred horses on modelling of the central and third tarsal bones could not be demonstrated. [less ▲]

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See detailQuantifying scale-dependent effects of cove-dwellers movements with connectivity models
Henry, Valérie ULg; Tercafs, R.

in Mémoires de Biospéologie (1999), XXVI

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See detailDiagnosis of myxomatosis by an indirect immunoperoxidase test
Marlier, Didier ULg; Boucraut-baralon, Corine; Vindevogel, Henri ULg

in Vlaams Diergeneeskundig Tijdschrift (1999), 68

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See detailAnalyse des débits de la Warche aux barrages de Butgenbach et de Robertville
Assani, A. A.; Petit, François ULg; Mabille, Georges ULg

in Bulletin de la Société Géographique de Liège (1999)

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See detailRecurrent abortion. Etiology and occurrence
VAN LINTHOUT, Christine ULg; Ahrendt, J.

in Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg (1999), (2), 59-71

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See detailGeneration of T lymphocytes from the epithelium and stroma of squamous pre-neoplastic lesions of the uterine cervix.
Jacobs, Nathalie ULg; Giannini, Sandra ULg; Al-Saleh, Walid et al

in Journal of Immunological Methods (1999), 223(1), 123-9

In this study, we have developed a simple and efficient technique for the isolation of viable lymphocytes from the epithelium and stroma of small pre-neoplastic squamous intraepithelial lesions (SIL) of ... [more ▼]

In this study, we have developed a simple and efficient technique for the isolation of viable lymphocytes from the epithelium and stroma of small pre-neoplastic squamous intraepithelial lesions (SIL) of the uterine cervix. Following the separation of the epithelium from the stroma using dispase II, both biopsy fragments were used to generate T lymphocytes. The stroma-derived lymphocytes were obtained by collecting and culturing the cells migrating out of the biopsy in the presence of IL2 (50 U/ml). An average of 0.7 x 10(6) and 1.4 x 10(6) lymphocytes could be obtained after 20 and 30 days of culture, respectively. For the expansion of lymphocytes derived from the pre-neoplastic epithelium (SIL) it was necessary to use a combination of irradiated peripheral blood mononuclear cells (PBMC) as a feeder layer with PHA (0.1%), in addition to IL2 (50 U/ml). Interestingly, these lymphocytes could be obtained using either allogeneic or syngeneic PBMCs. With this protocol, we were able to generate up to 100 x 10(6) lymphocytes from the epithelium, the majority of which were T lymphocytes. [less ▲]

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See detailFertilization by proxy: Rival sperm removal and translocation in a beetle
Haubruge, Eric ULg; Arnaud, L.; Mignon, Jacques ULg et al

in Proceedings of the Royal Society of London Series B-Biological Sciences (1999), 266(1424), 1183-1187

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See detailPaolo Rossi, Le Philosophe et les Machines (1400-1700)
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 38(printemps), 127-128

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See detail89 rue de Rome. Le rituel des “Mardis” mallarméens
Durand, Pascal ULg

in Art&Fact (1999), 18

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See detailIntervention sur quelques aspects économiques de la réforme
Jurion, Bernard ULg

in Revue de la Faculté de Droit de l'Université de Liège (1999)

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See detailPatterns of seasonal and interannual changes of surface chlorophyll concentration in the Black Sea revealed from the remote sensed data.
Nezlin, Nikolay Pavlovich; Kostianoy, Andrey G.; Grégoire, Marilaure ULg

in Remote Sensing of Environment (1999), 69

Several years of CZCS-measured surface pigment’s ecosystems (e.g., Shushkina et al., 1995; Vinogradov et concentrations in the Black Sea are analyzed to appraise al., 1995; 1996a,b; Nihoul et al., 1998 ... [more ▼]

Several years of CZCS-measured surface pigment’s ecosystems (e.g., Shushkina et al., 1995; Vinogradov et concentrations in the Black Sea are analyzed to appraise al., 1995; 1996a,b; Nihoul et al., 1998). The analysis of the seasonal and year-to-year fluctuations of phytoplank- the images of the ocean color collected with the help of ton biomass and understand the causes of these fluctua- remote sensing seems to be one of the most productive tions in terms of the Black Sea’s general dynamics. The methods of estimation the general patterns of temporal pattern of seasonal variations is typical for subtropical and spatial variations of plant pigment concentration in rather than temperate regions. The range of the absolute surface layer of sea water. value of plant pigment surface concentration measured The chlorophyll concentrations measured by remote by remote sensing does not differ greatly from the values sensing methods are known to be the subject of serious measured by direct methods. The pattern of year-to-year discrepancies as compared with in situ measurements variations seems to correlate with cyclic oscillations of (e.g., Chavez, 1995; Martin and Perry, 1994; Mitchell, winter air temperature. In western shallow regions it is 1992; Nihoul et al., 1998). However, these observations also correlated with the Danube discharge intensity. are rather regular and numerous; thus they are worth at- More intensive winter–spring blooms and a slightly lower tention for the analysis of the variations of the Black level of pigment concentration during warm season are Sea’s ecosystem. typical for years of with a mild winter. The causes of The Coastal Zone Color Scanner (CZCS) was develthese regularities seem to be the peculiarities of hydrolog- oped by NASA. It was launched on the Nimbus-7 satelical and meteorological regimes of the Black Sea. The in- lite in October 1978. During its 7.5 year lifetime (Octotensity of winter–spring bloom of phytoplankton appears ber 1978–June 1986), the CZCS acquired nearly 68,000 to depend on hydrological mechanism (i.e., the intensity images, each covering up to 2 million square kilometers of water mixing during winter period due to thermic con- of ocean surface. The Nimbus Project Office in collabovection and wind mixing) rather than the illumination in- ration with the National Aeronautics and Space Administensity. [less ▲]

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See detailLe trésor des reliques de l'abbaye Saint-Hubert en Ardenne
George, Philippe ULg

in Études & Documents de la Région Wallonne. Monuments & Sites (1999)

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See detailInvestigation on liquid maldistribution in packed beds by X-ray tomography
Marchot, Pierre ULg; Toye, Dominique ULg; Crine, Michel ULg et al

in Chemical Engineering Research & Design : Transactions of the Institution of Chemical Engineers Part A (1999), 77

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See detailLe point de vue de l'économiste
Jurion, Bernard ULg

in La nouvelle procédure fiscale, Commision Université-Palais (1999), XXX(II), 99-108

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See detailEvaluation du système de financement des journées hospitalières en fonction des pathologies
Fecher-Bourgeois, Fabienne ULg; Gillet, Pierre ULg

in Bulletin des Résumés d'Informations Hospitalières / Ministère des affaires sociales, de la santé publique et de l'environnement (1999), 16(Janvier/février/mars 1999),

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See detailLa gestion forestière durable en Région wallonne : L'apport de l'inventaire permanent - Partie 2 : Intégration des indicateurs à l'inventaire
Lecomte, Hugues; Koestel, G.; Rondeux, Jacques ULg

in Silva Belgica (1999), 106(2), 7-14

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau ... [more ▼]

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau régional, un inventaire forestier permanent peut, outre les variables et paramètres qu'il traite habituellement, prendre en charge ces indicateurs. Moyennant quelques ajustements méthodologiques, il s'est avéré dans le cas de la Région wallonne, que l'Inventaire des Ressources ligneuses pouvait, grâce aux techniques d'échantillonnage qu'il met en oeuvre, constituer un outil pertinent pour dresser un état des lieux du développement durable en milieu forestier. En outre, du fait de son caractère permanent, il permet d'assurer le suivi de l'évolution des critères et indicateurs au cours du temps. Nous rappellerons très brièvement les bases méthodologiques de l'inventaire forestier régional (paragraphe 2) et les résultats de l'étude qui était destinée à lui faire prendre en compte des indicateurs de gestion durable (paragraphe 3). Nous nous attacherons à montrer comment ces indicateurs sont concrètement, selon les cas, observés, mesurés, calculés et traités (paragraphe 4), puis nous tirerons les quelques conclusions qui paraissent s'imposer (paragraphe 5). [less ▲]

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See detailComment j'explore ... le risque coronarien individuel extrapole a 10 ans.
Scheen, André ULg; Rorive, Georges ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1999), 54(2), 118-21

The European Societies of Cardiology. Atherosclerosis and Hypertension agreed upon a table allowing to evaluate the coronary risk after 10 years according to five parameters (sex, age, smoking, total ... [more ▼]

The European Societies of Cardiology. Atherosclerosis and Hypertension agreed upon a table allowing to evaluate the coronary risk after 10 years according to five parameters (sex, age, smoking, total cholesterol, arterial blood pressure) and aggravating factors (familial history, diabetes mellitus, low HDL cholesterol, hypertriglyceridaemia). The risk level is based upon the equations of the prospective US study of Framingham. The calculation of such a risk is mainly interesting before considering intensified primary prevention in an individual free of any cardiovascular disease. The efforts should first focus on individuals with a high coronary risk, i.e. > 20% after 10 years. As far as secondary prevention is concerned, the patients should always be considered at high risk and beneficiate of all available therapeutic means. [less ▲]

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See detailPurification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors.
Kannan, R.; Ruff, M.; Kochins, J. G. et al

in Protein Expression & Purification (1999), 16

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has been shown to be involved in malignant tumor progression and therefore represents an attractive therapeutical target. In order to screen for ST3 ... [more ▼]

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has been shown to be involved in malignant tumor progression and therefore represents an attractive therapeutical target. In order to screen for ST3 synthetic inhibitors, we have produced and purified the catalytic domain of ST3, matrilysin, stromelysin-2, and membrane type-1 MMP from inclusion bodies in a bacterial system. Our strategy allowed the purification of MMPs directly in the active form, thereby avoidingin vitroactivation. A total of 140,000 synthetic compounds from the Bristol-Myers Pharmaceutical Research Institute chemical deck were tested, using a substrate-based colorimetric enzymatic assay, in which ST3 activity was evaluated through its ability to cleave and inactivate α-1 proteinase inhibitor. One ST3 inhibitor belonging to the cephalosporin family of antibiotics was thereby identified. [less ▲]

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See detailObzor verkhnego paleolita Moldavii
Otte, Marcel ULg; Noiret, Pierre ULg; López Bayón, Ignacio

in Stratum Plus (1999), 1

The existing in Moldova Aurignacian industries of the lamellar type are represented by the stone collections of two kinds: with leaf-shaped points and backed points with a concave edge. Together with this ... [more ▼]

The existing in Moldova Aurignacian industries of the lamellar type are represented by the stone collections of two kinds: with leaf-shaped points and backed points with a concave edge. Together with this the Corpach IV industry which includes backed points (segments) must have been related to Gravette. Other industries should not be considered separately and apparently can be grouped under the title "industries de type Paléolithique supérieur ancien à pointes foliacées". They are supposed to spring from the Middle Palaeolithic industries with leaf-shaped pieces (from Micoquian of Central Europe), that were further developed in the Aurignacian direction. If the Aurignacian of Moldova has evidently a foreign origin, then the Gravette traditions go back to some related centers. It is reflected in the compatibilty of backed pieces and leaf-shaped points in one and the same industry, dated back to the early stage of the Upper Palaeolithic. It is clearly seen in the collections of lower layers of Molodova V where homogeneousness of the complex is evident starting with the tenth layer. The appearance of some new types of tools (for instance, shouldered points) in the upper layers of this site does not fail the general stability and the cultural originality of the industry. [less ▲]

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See detailMimicry and the judgment of emotional facial expression
Blairy, Sylvie ULg; Herrera, P; Hess, U

in Journal of Nonverbal Behavior (1999), 23(1), 5-41

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See detailAnomalous behavior of the irreversible magnetization and time relaxation in YBa(2)Cu(3)O(7) single crystals with splayed tracks
Silhanek, Alejandro ULg; Niebieskikwiat, D.; Civale, L. et al

in Physical Review. B : Condensed Matter (1999), 60(18), 13189-13195

We have studied the angular dependence of the irreversible magnetization and its time relaxation in YBa(2)Cu(3)O(7) Single crystals with one or two families of columnar defects inclined with respect to ... [more ▼]

We have studied the angular dependence of the irreversible magnetization and its time relaxation in YBa(2)Cu(3)O(7) Single crystals with one or two families of columnar defects inclined with respect to the c axis. At high magnetic fields, the magnetization shows the usual maximum centered at the mean tracks' orientation and an associated minimum in the normalized relaxation rate. In contrast, at low fields we observe an anomalous local minimum in the magnetization and a maximum in the relaxation rate. We present a model to explain this anomaly based on the slowing down of the creep processes arising from the increase of the vortex-vortex interactions as the applied field is tilted away from the mean tracks' direction. [S0163-1829(99)11841-1]. [less ▲]

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See detailContribution of the carbohydrate moiety to conformational stability of the carboxypeptidase Y high pressure study.
Dumoulin, Mireille ULg; Ueno, H.; Hayashi, R. et al

in European Journal of Biochemistry (1999), 262(2), 475-83

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the ... [more ▼]

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the catalytic activity and, the intrinsic and 8-anilino-1-naphthalene sulfonic acid binding fluorescences. Pressure-induced denaturation of carboxypeptidase Y is a process involving at least three transitions. Low pressures (below 150 MPa) induced slight conformational changes characterized by a slight decrease in the center of the spectral mass of intrinsic fluorescence, whereas no changes in 8-anilino-1-naphthalene sulfonic acid binding fluorescence were observed and 80% of the catalytic activity remained. Higher pressure (150-500 MPa) induced further conformational changes, characterized by a large decrease in the center of the spectral mass of intrinsic fluorescence, a large increase in the 8-anilino-1-naphthalene sulfonic acid binding fluorescence and the loss of all catalytic activity. Thus, this intermediate exhibited characteristics of molten globule-like state. A further increase, in pressure (above 550 MPa) induced transition from this first molten globule-like state to a second molten globule-like state. This two-stage denaturation process can be explained by assuming the existence of two independent structural domains in the carboxypeptidase molecule. A similar three-transition process was found for unglycosylated carboxypeptidase Y, but, the first two transitions clearly occurred at lower pressures than those for glycosylated carboxypeptidase Y. These findings indicate that the carbohydrate moiety protects carboxypeptidase Y against pressure-induced denaturation. The origin of the protective effects is discussed based on the known crystallographic structure of CPY. [less ▲]

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See detailA new database of astrophysical interest
Biémont, Emile ULg; Palmeri, P.; Quinet, Pascal ULg

in Astrophysics & Space Science (1999), 269-270

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See detailCalcul et conception économique des assemblages de profilés reconstitués soudés
Braham, M.; Cerfontaine, F.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1999), (N°1), 5-24

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See detailLes nouveaux outils de l'amenagement forestier: l'exemple des systemes d'information geographique.
Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Revue Forestière Française (1999), 51(Numero special), 169-184

Forest managers have to collect, process and use huge amounts of data for analysis, planning or management purposes. Most of these data have a spatial component which make them useful for decision-making ... [more ▼]

Forest managers have to collect, process and use huge amounts of data for analysis, planning or management purposes. Most of these data have a spatial component which make them useful for decision-making. The development of information technology has given rise to specific tools for the processing of spatial data : Geographic Information Systems (GIS). The methodological improvements required to take full advantage of these tools in practical applications have not always followed the development of this technology. The main goal of this paper is to take stock of the potential for using GIS in forest management. The emphasis is on three questions : (i) what is a GIS, (ii) what is it useful for and (iii) how is it implemented ? [less ▲]

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See detailNew Therapeutic options
Reginster, Jean-Yves ULg; Henrotin, Yves ULg

in Bone Depeche (1999), 5

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See detailActualisation de la prise en charge de l'hypertension artérielle
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), (54), 683-687

The International Society of Hypertension and the World Heath Organisation have recently published new guidelines for the management of hypertension. Epidemiologic studies have shown that management of ... [more ▼]

The International Society of Hypertension and the World Heath Organisation have recently published new guidelines for the management of hypertension. Epidemiologic studies have shown that management of hypertension still remains insatisfactory. The aim of the treatment is to reduce the cardiovascular morbidity and mortality by normalizing blood pressure. The target blood pressure under treatment must be less than 140/90 mmHg, and even lower for diabetic or chronic renal failure patients. In parallel, all cardio-vascular risk factors have to be corrected to decrease the global cardio-vascular risk. [less ▲]

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See detailHypo- et hypertension intracrânienne bénigne
DELVAUX, Valérie ULg; DIOH, Alioune ULg; Schoenen, Jean ULg

in Revue Médicale de Liège (1999), 54(8), 671-676

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See detailPharma-clinics. Le medicament du mois. L'aceclofenac (Biofenac).
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 62-4

Aceclofenac, a phenylacetic acid derivative, is a new nonsteroidal anti-inflammatory drug (NSAID). It is indicated in the symptomatic treatment of pain and inflammatory or degenerative arthropathies ... [more ▼]

Aceclofenac, a phenylacetic acid derivative, is a new nonsteroidal anti-inflammatory drug (NSAID). It is indicated in the symptomatic treatment of pain and inflammatory or degenerative arthropathies: osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, abarticular inflammations, posttrauma or postoperative inflammations. The usual oral dosage of aceclofenac is 100 mg twice daily in adults. Its clinical efficacy seems to be similar to that of other NSAIDs, but its safety profile, especially gastro-intestinal tolerance, appears to be better. Finally, in vitro studies suggested that aceclofenac may exert positive effect on cartilage matrix metabolism. [less ▲]

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See detailTibère et l'astrologie (Suétone, Vie de Tibère, 36 et 69)
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1999), 58

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See detailCryptospores and spores from the Ordovician to the Llandovery. A review
Steemans, Philippe ULg

in Acta Universitatis Carolinae. Geologica (1999), (1/2), 271--274

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See detailBVD. L'infection chez le bovin
Thiry, Etienne ULg

in GDS info (1999), 133-134

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See detailViaticum = facultas
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1999), 58

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See detailClinical evaluation of processing techniques for attenuation correction with 137Cs in whole-body PET imaging.
Benard, F.; Smith, R. J.; Hustinx, Roland ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1999), 40(8), 1257-63

Transmission scanning can be successfully performed with a 137Cs single-photon emitting point source for three-dimensional PET imaging. However, the attenuation coefficients provided by this method are ... [more ▼]

Transmission scanning can be successfully performed with a 137Cs single-photon emitting point source for three-dimensional PET imaging. However, the attenuation coefficients provided by this method are underestimated because of the energy difference between 662- and 511-keV photons, as well as scatter and emission contamination when the transmission data are acquired after injection. The purpose of this study was to evaluate, from a clinical perspective, the relative benefits of various processing schemes to resolve these issues. METHODS: Thirty-eight whole-body PET studies acquired with postinjection singles transmission scans were analyzed. The transmission images were processed and applied to the emission data for attenuation correction. Three processing techniques were compared: simple segmentation (SEG) of the transmission scan, emission contamination subtraction with scaling (ECS) of the resulting data to 511-keV attenuation coefficient values and a hybrid technique performing partial segmentation of some tissue densities on the ECS scan (THR). The corrected emission scans were blindly assessed for image noise, the presence of edge artifacts at the lung-soft-tissue interface and for overall diagnostic confidence using a semiquantitative scoring system. The count densities and the SDs in uniform structures were compared among the various techniques. The observations for each method were compared using a paired t test. RESULTS: The SEG technique produced images that were visually less noisy than the ECS method (P < 0.0001) and the THR technique, but at the expense of increased edge artifacts at the boundaries between the lungs and surrounding tissues. The THR technique failed to eliminate these artifacts compared with the ECS technique (P < 0.0001) but preserved the activity gradients in the hilar areas. The count densities (and thus, the standardized uptake values) were similar among the three techniques, but the SEG method tended to underestimate the activity in the lung fields and in chest tumors (slope = 0.79 and 0.94, respectively). CONCLUSION: For many clinical applications, SEG data remain an efficient method for processing 137Cs transmission scans. The ECS method produced noisier images than the other two techniques but did not introduce artifacts at the lung boundaries. The THR technique, more versatile in complex anatomic areas, allowed good preservation of density gradients in the lungs. [less ▲]

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See detailLa cartographie des contraintes karstiques en Région wallonne (Belgique)
Ek, Camille ULg; Michel, Raymond; Jaspar, Annick

in Bulletin de la Société Géographique de Liège (1999), 36

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See detailBarotropic and baroclinic oscillations in strongly stratified ocean basins - Numerical study of the Black Sea
Stanev, Emil; Beckers, Jean-Marie ULg

in Journal of Marine Systems (1999), 19(1-3), 65-112

We investigate barotropic and baroclinic oscillations in strongly stratified basins using the Black Sea as a test case. The GHER 3D-model, which has active free surface and temperature and salinity fields ... [more ▼]

We investigate barotropic and baroclinic oscillations in strongly stratified basins using the Black Sea as a test case. The GHER 3D-model, which has active free surface and temperature and salinity fields as scalar state variables produces model results which are then analysed with a focus on barotropic and baroclinic waves at different scales. The model is forced by seasonally variable climatic data and river run-off. High frequency oscillations of the sea level simulated by the model are compared against observations. It is found that phases and amplitudes are simulated realistically. For the density field, long internal gravity waves dominate the solution in the sub-inertial range, The amplitudes of these oscillations increase over the continental slope, which provides an efficient mechanism for mixing in the western Black Sea. It is found that the sea surface oscillations interact with the oscillations in the pycnocline. This interaction could contribute to a modification of the vertical stratification in a long run. The vertical stratification, on its side, jointly with the bottom relief causes different appearances of oscillations over the continental slope and in the basin interior. Changes in the stability of stratification, caused by the seasonal cycle, are thus an important factor modifying wave processes and the resulting internal mixing. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMélanges Philippe Minguet
Duchesne, Jean-Patrick ULg

in Art&fact (1999), 18

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See detailLe cas clinique du mois. Diagnostic et traitement du kyste adventitiel de l'artere poplitee.
Zeaiter, R.; SakalihasanN, Natzi ULg; VAN DAMME, Hendrik ULg et al

in Revue Médicale de Liège (1999), 54(6), 514-6

The authors report the case of a 66-year-old patient with unilateral intermittent claudication, in whom no evidence of intravascular occlusive disease was found. Surgical approach revealed an ... [more ▼]

The authors report the case of a 66-year-old patient with unilateral intermittent claudication, in whom no evidence of intravascular occlusive disease was found. Surgical approach revealed an intraparietal cystic adventitial disease of the popliteal artery. An excision of the affected segment and bypass grafting with the internal saphenous vein was done. [less ▲]

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See detailLe Traçage : un outil pour l'établissement des zones de surveillance des captages en terrain karstique. Le cas de Hastière (Province de Namur, Belgique)
Michel, Goerges; Meus, Philippe ULg; Thys, Georges et al

in Bulletin de la Société Géographique de Liège (1999), 37

In response to the request of the Groundwater Service of the Walloon Region, the Commission Wallonne d'Etude et de Protection des Sites Souterrains (CWEPSS) has carried out underground water tracing in ... [more ▼]

In response to the request of the Groundwater Service of the Walloon Region, the Commission Wallonne d'Etude et de Protection des Sites Souterrains (CWEPSS) has carried out underground water tracing in the karstic area of Hastière (Province of Namur, Belgium).The CWEPSS has carried on the task with the cooperation of Geologica SA, Gembloux, for the tracing tests and the collaboration of the Université de Liège for several related parameters (stream gauging, water analyzes, spectrofluorimetry, etc.). At Hastière, several karstic Springs resurge from a large and complex limestone syncline; two water supply stations pump water from this syncline for local use. Fluorescent tracers have been injected into three swallowholes. Three different tracers have been used simultaneously - one in each injection site. They have been traced downstream in 9 potential points of reappearance. In a single one-month field-campaign, the origin of 9 streams has been questioned. Despite the low-water levels during this period, some underground streams have covered more than 3,5 km in 8 days. This shows how important is to permanently watch water supplies in karstic areas. The water intake of the Municipality at Anthée proved to be clean, unpolluted. The authors could define the watch-zone and delineate a prioritary watch sub-zone in the geological formation supplying directly the intake. A private camping intake appeared to be supplied by a sinkhole collecting water from a water purifying station and by another sinking stream swallowing sewage water, hence a high pollution and an important sanitary problem. These findings, among others, show how us « the water tracing technique is in detecting sources and in defining watch and protection zones. [less ▲]

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See detailExecutive dysfunction in Alzheimer's disease
Collette, Fabienne ULg; Van der Linden, Martial ULg; Salmon, Eric ULg

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (1999), 35(1), 57-72

Executive functioning was examined in 20 patients with Alzheimer's disease (AD) and 20 normal elderly subjects. The results showed that AD patients present lower performance compared to control subjects ... [more ▼]

Executive functioning was examined in 20 patients with Alzheimer's disease (AD) and 20 normal elderly subjects. The results showed that AD patients present lower performance compared to control subjects in all executive tasks, confirming that some executive deficits may be present in the first stages of the disease. A factorial analysis suggested that these deficits can be related to two domains of the executive functions: the inhibition abilities and the capacity to co-ordinate simultaneously storage and processing of information. Moreover, the performance on these factors is correlated to different anterior and posterior cortical areas. [less ▲]

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See detailFibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review.
VAN DAMME, Hendrik ULg; SakalihasanN, Natzi ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1999), 99(4), 163-8

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two ... [more ▼]

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two suffered from a minor stroke, four had non-focalized ischemic cerebral symptoms and two were asymptomatic. At angiography, all patients showed a typical image of "string of beads". Seven patients were operated on. Six had endoluminal graduated dilatation, with rigid dilators up to 4.5 mm, associated with thrombendarterectomy of the bifurcation in three and to correction of a kink in one case. In one case a venous interposition graft was done to exclude a saccular microaneurysm of the dysplasic internal carotid artery. In another case, backflow was insufficient after endoluminal dilatation, and a long venous patch allowed to restitute a normal vascular lumen. There was neither postoperative mortality nor stroke. Six patients, asymptomatic or with non focalized symptoms, were treated medically. During a mean follow-up of 47 months, only one of the 13 patients developed a transient ischemic attack; the patient had not been operated on and received only medical treatment. Prevalence, etiopathology, diagnosis and management of fibromuscular dysplasia of the internal carotid artery are discussed. Fibromuscular dysplasia is a rare cause of cerebral ischemia. For asymptomatic lesions, a conservative approach seems appropriate. Surgery is only to be considered for symptomatic lesions. Surgical graduated endoluminal dilatation, where necessary combined with standard endarterectomy of the carotid bifurcation, is a safe, efficient and durable operation. Some complex cases of fibromuscular dysplasia may necessitate patch insertion or excision and graft interposition. [less ▲]

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See detailLes convergences culturelles dans les sociétés pluriethniques de K. Fall et al.
Martiniello, Marco ULg

in Recherches Sociologiques (1999), 2

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See detailIGF-II in primary human colorectal tumors: peptide level, activated promoters, parental imprinting and gene rearrangement.
Winkler, Rose ULg; Delacroix, Laurence ULg; Bensbaho, K. et al

in Hormone & Metabolic Research (1999), 31(2-3), 148-54

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary ... [more ▼]

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary human colon cancers. Here we show that the IGF-II peptide content is increased in six primary colon cancers compared to the corresponding healthy tissues. The IGF-II transcripts in healthy and cancerous colon tissues were identified by Northern blotting and RT-PCR. Promoters P3 and P4 were active in most tissues. Relaxation of parental imprinting was observed in two tumors and one healthy tissue, without any correlation with the IGF-II transcript levels. Rearrangements of the IGF-II gene in two tumors containing very high amounts of IGF-II mRNA are described. Fragments containing the breakpoints were cloned by the vectorette-PCR strategy. In both tumors, the breakpoints occurred in repetitive sequences. In one tumor (T11), the breakpoint was localized 2 kb downstream the end of exon 9. The second tumor (T18) contains two modified alleles. In one rearranged allele the breakpoint is located in exon 9. The exact position of the breakpoint in the second rearranged allele has not been identified. In future experiments, the correlation between the gene rearrangements and IGF-II mRNA overexpression will be studied. [less ▲]

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See detailThe pathology of Psoroptes ovis infestation in cattle with a special emphasis on breed difference
Losson, Bertrand ULg; Lonneux, J. F.; Lekimme, Mireille ULg

in Veterinary Parasitology (1999), 83

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See detailAt the center, what?’ Giacomo Joyce, Roland Barthes and the Novelistic Fragment
Delville, Michel ULg

in James Joyce Quarterly (1999), 36(4), 765-780

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See detailUn orteil douloureux
Vanhooteghem, Olivier ULg; Richert, Bertrand ULg; de LA BRASSINNE, Michel ULg

in Revue de Médecine Générale [=RMG] (1999), 16

Case story of a patient with a painfull sub-ungueal tumentia.

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See detailMolecular Evidence For An Andean Origin And A Secondary Gene Pool For The Lima Bean (Phaseolus Lunatus L..) Using Chloroplast Dna
Fofana, B.; Baudoin, Jean-Pierre ULg; Vekemans, X. et al

in Theoretical and Applied Genetics (1999), 98(2),

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See detailHypodermose bovine dans le Nord-Est algérien : prévalence et intensité d'infestation
Benakhla, A.; Lonneux, J. F.; Mekroud, A. et al

in Veterinary Research (1999), 30

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See detailAn imprinted QTL with major effect on muscle mass and fat deposition maps to the IgfII locus in pigs
Nezer, C.; Moreau, L.; Brouwers, B. et al

in Nature Genetics (1999), 21

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See detailFactors determining the percentage of hypochromic red blood cells in hemodialysis patients.
Bovy, Christophe ULg; Tsobo, C.; Crapanzano, L. et al

in Kidney International (1999), 56(3), 1113-9

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO ... [more ▼]

Factors determining the percentage of hypochromic red blood cells determines iron status in hemodialysis patients. BACKGROUND: Determination of the percentage of hypochromic red blood cells (RBC; %HYPO) has been advocated as a sensitive index of functional iron deficiency during erythropoietin (EPO) therapy in hemodialyzed patients. METHODS: The significance of %HYPO in chronic renal failure was evaluated in 64 chronically hemodialyzed patients. The linear correlation was determined between %HYPO and 13 variables, including age, sex, weight, C-reactive protein (CRP), ferritin, transferrin (Tf), Tf saturation, soluble Tf receptor (sTfR), serum iron (SI), urea, parathormone, dialysis dose (Kt/V), dose of EPO administered (EPO), and absolute reticulocyte count. Multiple regression analyses were then performed to select the parameters that jointly provide the best prediction of %HYPO. RESULTS: Univariate analysis showed significant correlations between %HYPO and iron parameters (sTfR, Tf saturation, SI, and ferritin, in decreasing order), EPO, reticulocyte count, and CRP. Multivariate analysis yielded an equation showing that the variation of %HYPO is essentially associated with the combined changes in sTfR, CRP, and EPO dosage. CONCLUSIONS: %HYPO is a meaningful and inexpensive parameter that reflects the integrated effects of iron stores, inflammation, and erythropoietic stimulation on iron availability in hemodialyzed patients. Among iron exchange parameters, sTfR is the best predictor of %HYPO, followed by Tf saturation, SI, and ferritin. [less ▲]

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See detailCompte-rendu de l'ouvrage de Bawin-Legros Bernadette : Familles modes d'emploi. Étude sociologique des ménages belges
Orianne, Jean-François ULg

in Recherches Sociologiques et Anthropologiques (1999), (3),

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See detailSerine peptidase catalytic machinery: Cooperative one-step mechanism
Dive, Georges ULg; Dehareng, Dominique ULg

in International Journal of Quantum Chemistry (1999), 73(2), 161-174

The acylation reaction of beta-lactamases by beta-lactam compounds is modeled as a one-step process. Twenty seven transition-state models are investigated at the restricted Hartree-Fock (RHF) level within ... [more ▼]

The acylation reaction of beta-lactamases by beta-lactam compounds is modeled as a one-step process. Twenty seven transition-state models are investigated at the restricted Hartree-Fock (RHF) level within the minimal MINI-1' basis set. These transition states differ by the nature of both the substrate and the amino acids constituting the reactive nucleophile. The intrinsic reactivity of the class-A and class-C beta-lactamases are under concern. Eight transition-state models were docked in a class-A beta-lactamase, TEM1, as optimized with the benzylpenicillin at the molecular mechanics level. In the proposed one-step acylation process, only two amino acids are directly involved, the usual nucleophilic serine, S70 in TEM1, and a close serine or tyrosine, S130 in TEM1, Y150 in P99. The lysine close to these two residues, K73 in TEM1, plays only an indirect role in the process. (C) 1999 John Wiley & Sons, Inc. Int J Quant Chem 73: 161-174, 1999. [less ▲]

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See detailUne justice pénale européenne après Amsterdam
Flore, Daniel ULg

in Journal des Tribunaux Droit Européen (1999)

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See detailActualités thérapeutiques dans le traitement du cancer colorectal
Jerusalem, Guy ULg; Bours, Vincent ULg; Fillet, Georges ULg

in Médecine et Hygiène (1999), 57

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See detailLe sémioticien
Durand, Pascal ULg

in Art&Fact (1999), (18), 81-82

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See detailThe influence of cortical perforations and of space filling with peripheral blood on the kinetics of guided bone generation. A comparative histometric study in the rat.
Rompen, Eric ULg; Biewer, Robert; Van Heusden, Alain ULg et al

in Clinical Oral Implants Research (1999), 10(2), 85-94

The aim of the present study was to evaluate the influence of cortical perforations and of peripheral blood addition in guided bone generation beyond the skeletal envelope in rats. A total of 30 isogenic ... [more ▼]

The aim of the present study was to evaluate the influence of cortical perforations and of peripheral blood addition in guided bone generation beyond the skeletal envelope in rats. A total of 30 isogenic adult rats were divided into 3 equal groups. In each rat, two hollow parallelipipedic titanium chambers were placed bilaterally on the calvaria after a periosteal skin flap was raised. While on the right sides (controls) the osseous surface was left intact and the chambers were empty, the cortical bone under the left-side chambers (test sites) was perforated with nine 0.8 mm-diameter holes (group I), or left intact but with the chambers filled with a clot of peripheral blood (group II). In group III, both procedures were combined in the test sites. The healing was assessed at 4, 8 and 16 weeks after surgery by histologic and computer-assisted histometric analysis. The results demonstrated a substantial augmentation of on average 141% (SD 18) of the skull's thickness after 16 weeks in the controls, indicating that a predictable bone formation can be achieved beneath completely occlusive barriers over a non-injured cortical layer. In all test groups, a significantly larger bone augmentation was observed after 16 weeks compared to the control sites 172.8% (SD 41.7) in group I (P < 0.05), 172.0% (SD 18.4) in group II (P < 0.05) and 221.5% (SD 42.3) in group III (P < 0.001), demonstrating that stimulating blood supply and bone forming cells access by cortical perforations and/or blood clot addition enhances de novo bone formation in this experimental model. [less ▲]

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See detailLocalization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis
Jacquemin, Patrick; Depetris, Danielle; Mattei, Marie-Geneviève et al

in Genomics (1999), 55(1), 127-9

Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEF-1) and is implicated in neural development. Isolation and ... [more ▼]

Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEF-1) and is implicated in neural development. Isolation and characterization of the cosmid clones encoding the mouse ETF gene (Etdf) revealed thatEtdfspans approximately 17.9 kb and consists of 12 exons. The exon–intron structure ofEtdfclosely resembles that of theDrosophila scallopedgene, indicating that these genes may have evolved from a common ancestor. The multiple transcription initiation sites revealed by S1 protection and primer extension analyses are consistent with the absence of the canonical TATA and CAAT boxes in the 5′-flanking region, which contains many potential regulatory sequences, such as the E-box, N-box, Sp1 element, GATA-1 element, TAATGARAT element, and B2 short interspersed element (SINE) as well as several direct and inverted repeat sequences. TheEtdflocus was assigned to the proximal region of mouse chromosome 7 using fluorescencein situhybridization and linkage mapping analyses. These results provide the molecular basis for studying the regulation,in vivofunction, and evolution ofEtdf. *1 The approved gene symbol for embryonic TEA domain-containing factor (ETF) by MGD isEtdf.The nucleotide sequences reported in this paper have been deposited with the GenBank/EMBL/DDBJ Data Libraries under Accession Nos. D83586–D83596. Mapping data from this article have been deposited in the Mouse Genome Database under Accession Nos. MGD-CREX-618 for genetic mapping and MGD-INEX-21 forin situhybridization, respectively. [less ▲]

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See detailIndices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction
Art, Tatiana ULg; Kirschvink, Nathalie; Smith, Nicola et al

in Equine Veterinary Journal (1999), 31(5), 397-401

To test the hypothesis that reactive oxygen species could be associated to the lower airway disorders occurring in horses suffering from recurrent airway obstruction (RAO), indices of oxidative stress ... [more ▼]

To test the hypothesis that reactive oxygen species could be associated to the lower airway disorders occurring in horses suffering from recurrent airway obstruction (RAO), indices of oxidative stress were studied in blood and pulmonary epithelium lining fluid in 5 RAO horses either in clinical remission or 24 h after the onset of a crisis of bronchospasm and in 5 healthy horses. Venous blood and bronchoalveolar lavage fluid (BALF) samples were collected and analysed for reduced glutathione (GSH), oxidised glutathione (GSSG), total glutathione (TGSH), glutathione redox ratio (GRR) in blood haemolysate and pulmonary epithelium lining fluid (PELF). The haemolysate concentrations of GSH, GSSG, TGSH and GRR were similar in the 3 groups. The PELF glutathione status was significantly different in the RAO horses in acute crisis compared to healthy horses, indicating the occurrence of an oxidative stress. When RAO horses were in crisis their GSH and TGSH remained unchanged but their GSSG and GRR were significantly increased compared to the remission. These results support the hypothesis that oxidative stress is associated with lower airway disorders occurring in horses suffering from RAO [less ▲]

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See detailPerturbative evolution and Regge behaviour
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P. V.

in Physics Letters B (1999), 448

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See detailC. R. de Raimon Gaucelm de Béziers, Poesie. Edizione critica a cura di Anna Radaelli
Henrard, Nadine ULg

in Lettres Romanes (1999), LIII(1-2), 193-194

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See detailEthnic Mobilisation and political participation in Europe
Martiniello, Marco ULg; Statham, P.

in Journal of Ethnic and Migration Studies (1999), 25(4),

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See detailLa mortalité embryonnaire. 1. Aspects cliniques et facteurs étiologiques dans l'espèce bovine
Hanzen, Christian ULg; Drion, Pierre ULg; Lourtie, O. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailTreatment of osteoporosis : where are we and where are we going to
Reginster, Jean-Yves ULg

in Morphologie : Bulletin de l'Association des Anatomistes (1999), 83(261), 41-5

In the past years, there has been a multiplication of drugs identified as candidates for use in the prevention or the treatment of osteoporosis. When treating established osteoporosis, the objective is to ... [more ▼]

In the past years, there has been a multiplication of drugs identified as candidates for use in the prevention or the treatment of osteoporosis. When treating established osteoporosis, the objective is to prevent further skeletal deterioration, improve bone mass and/or bone microarchitecture to provide a documented reduction of the risk of vertebral and/or peripheral fractures. Calcium and vitamin D have been shown to be particularly efficient in elderly patients, mainly to prevent non-vertebral fractures. By inhibiting osteoclastic activity, calcitonin improves bone mineral density at all sites. Preliminary results suggest that it might also decrease vertebral fracture rates. Bisphosphonates have been investigated for 20 years in the treatment of osteoporosis. Alendronate was shown to reduce spinal and extravertebral fractures. New formulations of fluoride, like monofluorophosphate appear to be particularly beneficial in women with mild to moderate osteoporosis. Several new compounds, including parathormone, strontium salts, ipriflavone or others are currently developed and subject to large investigational programs to demonstrate their ability to reduce fracture. [less ▲]

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See detailIdentification Of Mitochondrial Plasmid Like Dnas In Picea Abies (L.) Karst.
Chandelier, A.; Du Jardin, Patrick ULg; Avril, C. et al

in Plant Cell Reports (1999), 18(10),

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See detailMachiavellian Rethoric. From the Counter-Reformation to Milton, Princeton.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1999)

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See detailL'université, entre pouvoirs et contre-pouvoir
Bachelet, Jean-François ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1999), 85-86-87(1999), 51-60

Réflexion sur la signification du processus de transformation de l'institution universitaire.

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See detailNumerical simulation of compacting process of a multi-stepped part – Comparison with experiments
Mosbah, P.; Shima, S.; Habraken, Anne ULg et al

in Journal of the Japan Society of Powder and Powder Metallurgy (1999), 46

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See detailGrowth Hormone and parturition adversely influence immuno-reactive Plasma Insulin-like Growth Factor Binding Protein-2 in Cattle
Vleurick, Lieve; Vandehaar, Michael; Bertozzi, Carlo et al

in Growth Regulation (1999), 9

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See detailProphylactic Use of Alfacalcidol in Corticosteroid-Induced Osteoporosis
Reginster, Jean-Yves ULg; Kuntz, D.; Verdickt, W. et al

in Osteoporosis International (1999), 9(1), 75-81

One hundred and forty-five patients suffering from diseases requiring long-term treatment with high doses of corticosteroids (30 mg/day or greater of prednisolone) were recruited to the study. Patients ... [more ▼]

One hundred and forty-five patients suffering from diseases requiring long-term treatment with high doses of corticosteroids (30 mg/day or greater of prednisolone) were recruited to the study. Patients had to be steroid naive on entry to the study (not more than 15 days of treatment with a corticosteroid within the previous 24 months). Patients were randomized to receive either 1 microgram/day alfacalcidol or placebo capsules for 12 months. Bone mineral density (BMD) of the lumbar spine was assessed by dual-photon absorptiometry on entry and after 3, 6 and 12 months' treatment. Safety was monitored by the recording of all adverse events reported by patients and the regular screening of blood samples for hematology and serum biochemistry. Of the 145 patients, 74 were randomized to alfacalcidol and 71 to placebo. The treatment groups were well matched at baseline with no significant differences in demographic, clinical or biochemical parameters. The mean equivalent dose of prednisolone at baseline was 46.6 mg/day and 46.3 mg/day for the alfacalcidol and placebo group respectively. From the 145 patients randomized to treatment, 71 (38 who received alfacalcidol and 33 who received placebo) provided BMD data both at baseline and at 3, 6 and 12 months. The percentage change in BMD after 6 months' treatment was -2.11% in the alfacalcidol group and -4.00% in the placebo group (p = 0.39). After 12 months the percentage change in BMD was +0.39% (CI: -4.28 to 4.81) in the alfacalcidol group and -5.67% (CI: -8.13 to -3.21) in the placebo group, this difference (6.06%, CI: 0.88 to 11.24) being statistically significant (p = 0.02). An intention to treat analysis also showed a significant difference between the two treatment groups in alfacalcidol's favor (3.81%, p = 0.01; CI: 0.92 to 6.70). There was no significant difference between the two treatment groups in the corticosteroid dose at any time point during the study. Serum calcium was measured throughout and there were no significant differences between the two treatment groups at any visit. This study suggests that alfacalcidol can prevent corticosteroid-induced bone loss from the lumbar spine. Long-term use of alfacalcidol was not associated with any significant adverse effects in this diverse group of patients. [less ▲]

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See detailCell surface immunophenotype and gelatinase activity of the human breast carcinoma cell line (MCF-7/6) with functionally defective E-cadherin.
Hlavcak, P.; Sedlakova, O.; Sedlak, J. et al

in Neoplasma (1999), 46(1), 12-6

Expression of differentiation and adhesion cell surface antigens (LewisX - CD15, CD44, syndecan 1 - CD138 and basigin/EMMPRIN - CD147) were determined on the cell surface of human breast carcinoma MCF7 ... [more ▼]

Expression of differentiation and adhesion cell surface antigens (LewisX - CD15, CD44, syndecan 1 - CD138 and basigin/EMMPRIN - CD147) were determined on the cell surface of human breast carcinoma MCF7 cells in vitro with the aid of flow cytometry and compared with that of MCF-7/6 cells, with functionally defective E-cadherin system and increased biological aggressiveness. The major cell surface alterations in MCF-7/6 cells compared with the parental MCF-7 cell line were a markedly increased CD15 (LewisX) and CD44 antigen cell surface expression on MCF-7/6 cells. There were no major differences between parental MCF-7 and MCF-7/6 cells in cell surface syndecan 1, basigin/EMMPRIN, E-cadherin and high affinity non-integrin laminin receptor expression. The constitutive cell surface gelatinase A and B activities were absent on MCF-7 and faint in MCF-7/6 cells. Both phorbol ester TPA and tumor necrosis factor TNF-alpha induced a marked up-regulation of gelatinase B only in MCF-7/6 cells. No marked differences in penetration of MCF-7 vs. MCF-7/6 cells into collagen/fibroblast matrix in vitro were observed. The increased expression of CD15 (LewisX), CD44 antigen and TNF-alpha-inducible gelatinase B on MCF-7/6 cells may represent auxiliary factors contributing to the increased biological aggressiveness of MCF-7/6 cells. [less ▲]

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See detailPeripheral blood progenitor cell collections in cancer patients: analysis of factors affecting the yields.
Sautois, Brieuc ULg; Fraipont, V.; Baudoux, Etienne ULg et al

in Haematologica (1999), 84(4), 342-9

BACKGROUND AND OBJECTIVE: Peripheral blood progenitor cells (PBPC) are now widely used to restore hematopoiesis following high dose chemotherapy in patients with malignancies. We sought to identify ... [more ▼]

BACKGROUND AND OBJECTIVE: Peripheral blood progenitor cells (PBPC) are now widely used to restore hematopoiesis following high dose chemotherapy in patients with malignancies. We sought to identify parameters that could predict the yield of PBPC after mobilization with chemotherapy (CT) with or without granulocyte colony-stimulating factor (G-CSF) in cancer patients. DESIGN AND METHODS: One hundred and fifty patients underwent 627 PBPC collections during the recovery phase following CT with (n = 469) or without (n = 142) G-CSF. Hemogram, CFC-assays and CD34+ cell count were performed on peripheral blood and leukaphereses products. After log transformation of the data, differences between groups were assessed with the unpaired t-test or one-way analysis of variance. RESULTS: Seventeen and two patients required 2 and 3 mobilization cycles respectively to reach our target of 15x10(4) CFU-GM/kg. In patients with lymphoma but not in those with leukemia, the yields of both CFU-GM and CD34+ cells/kg were dramatically increased when G-CSF was added to CT for mobilization. In collections primed with CT and G-CSF, better yields were obtained in patients with breast cancer or small-cell lung carcinoma (SCLC) as opposed to other solid tumors and leukemia. Among potential predictive factors of CT- and G-CSF-primed harvests, we found that the CD34+ cell count in peripheral blood (PB) was strongly correlated with both the CFU-GM and CD34+ cell yields. Except in leukemia patients, more than 1x10(6) CD34+ cells/kg were harvested when the CD34+ cell count in blood was above 20x10(6)/L. Similarly, better results were obtained in collections performed when the percentage of myeloid progenitors in blood on the day of apheresis was above 5 % or when the leukocyte count in blood was above 5x10(9)/L. INTERPRETATION AND CONCLUSIONS: A diagnosis of breast cancer or SCLC, a leukocyte count in PB of more than 5x10(9)/L, more than 5% myeloid progenitors or more than 20x10(6) CD34+ cells/L in PB were associated with higher yields of PBPC in collections mobilized with CT+G-CSF. [less ▲]

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See detailLa mesure du courant critique des matériaux supraconducteurs à haute température critique
Vanderbemden, Philippe ULg

in Bulletin de l'Association des Ingénieurs sortis de l'Université de Liège (AILg) (1999), 6

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See detailThree-dimensional Kinetic Energy Distributions of Ions using a Retarding Potential Analyser. Analysis of Discimination Effects by Ion Trajectory Simulations.
Hoxha, A.; Leyh, Bernard ULg; Locht, Robert ULg

in Rapid Communications in Mass Spectrometry : RCM (1999), 13

This paper presents a method of extracting three-dimensional kinetic energy distributions from retarding potential curves, suitable for analysing low kinetic energy releases. Trajectory calculations were ... [more ▼]

This paper presents a method of extracting three-dimensional kinetic energy distributions from retarding potential curves, suitable for analysing low kinetic energy releases. Trajectory calculations were performed which led to an analytical function correcting for the influence of discrimination against ions with velocity components perpendicular to the retarding field direction. The analysis of the thermal kinetic energy distribution of molecular vinyl bromide ions confirms the computed correcting factor. [less ▲]

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See detailInvariant bidifferential operators on tensor densities over a contact manifold
Mathonet, Pierre ULg

in Letters in Mathematical Physics (1999), 48(3), 251-261

The spaces of tensor densities over a manifold M are modules over the Lie algebra Vect (M) of vector fields over the manifold. When M is a contact manifold, one can consider the algebra C(M) of vector ... [more ▼]

The spaces of tensor densities over a manifold M are modules over the Lie algebra Vect (M) of vector fields over the manifold. When M is a contact manifold, one can consider the algebra C(M) of vector fields which preserves the contact structure. If the manifold is endowed with a contact projective structure, there is an embedding of the linear symplectic algebra sp (2n+2,R) in C(M). In this Letter, we determine the C(M)- and the sp(2n+2,R)-invariant bidifferential operators on tensor densities. [less ▲]

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See detailLa pollution de la chaîne alimentaire par la dioxine
Maghuin-Rogister, Guy ULg; Delaunois, A.; De Pauwe, E. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailAnalysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.
Wang, Xingjun ULg; Tromp, G.; Cole, C. W. et al

in Matrix Biology (1999), 18(2), 121-4

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of ... [more ▼]

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of tissue remodeling are therefore candidate genes. We analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms (AAA), one individual with AAA and intracranial aneurysms (IA), four individuals with IA and two clinically unaffected individuals. We identified two nucleotide variants in both the TIMP1 and the TIMP2 coding sequences. All differences occurred in the third base positions of codons and were neutral polymorphisms. A significant difference was observed in the frequency of TIMP2 nt 573 polymorphism between 168 alleles from AAA patients and 102 control alleles. [less ▲]

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See detailInhalation therapy of equine respiratory disorders
Duvivier, D. H.; Votion, Dominique ULg; Roberts, C. A. et al

in Equine Veterinary Education (1999), 11(3), 124-130

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See detailPregnancy-Associated Glycoprotein and progesterone profiles during pregnancy and postpartum in native goats from north-east of Brazil.
Melo de Sousa, Noelita ULg; Garbayo, J. M.; Figueiredo, J. R. et al

in Small Ruminant Research (1999), 32

Pregnancy diagnosis is a critical procedure for monitoring goat reproductive performance. In the present investigation, pregnancy-associated glycoprotein (PAG) profiles during pregnancy and first month ... [more ▼]

Pregnancy diagnosis is a critical procedure for monitoring goat reproductive performance. In the present investigation, pregnancy-associated glycoprotein (PAG) profiles during pregnancy and first month postpartum, as well as progesterone (P4) concentrations throughout pregnancy, were determined in native goats from the north-east of Brazil. A total of 30 goats (Moxoto, n = 19 and Caninde, n = 11) were used. Peripheral blood was collected on days 0 (Day 0 = AI), 11, 16, 18, 20, 24 and 30 after AI. Samples were subsequently collected every 2 weeks until day 145, and weekly during the first month postpartum. The levels of PAG and P4 were determined by radioimmunoassay (RIA). The profiles of PAG were not different between the breeds throughout pregnancy. However, a significant effect of the week of pregnancy (p < 0.01) and the number of fetuses (p < 0.05) in PAG concentrations were found. Lower concentrations of PAG were observed during weeks 1 and 3, compared to the rest of the gestation. Thereafter, there was a significant (p < 0.05) increase in PAG concentrations from week 5 to 7 and a significant decrease (p < 0.05) in week 9. The PAG concentrations remained relatively constant until week 17, and finally decreased slowly until parturition. After parturition, PAG concentrations decreased rapidly, and continued to decrease until week 4. During pregnancy, mean P4 concentrations had weekly variations among the animals (p < 0.01) and the period of pregnancy (p < 0.01), but P4 was not affected by the breed or number of fetuses. These results indicate that PAG and P4 concentrations were similar for Caninde and Moxoto goats and that, for both the breeds, the stage of pregnancy and the number of fetuses could influence PAG production. [less ▲]

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See detailLa notion d'incapacité de travail personnel
Boxho, Philippe ULg

in Revue de Droit Pénal et de Criminologie (1999), 1

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See detailContribution de l'hypertension arterielle au risque vasculaire du diabetique.
Marre, M.; Bouhanick, B.; Hadjadj, S. et al

in Diabètes & Métabolism (1999), 25 Suppl 3

Hypertension is a major cardiovascular risk factor in diabetic subjects. Recent trials have suggested that blood pressure objectives should be < or = 140/80 mmHg. However, there is currently no evidence ... [more ▼]

Hypertension is a major cardiovascular risk factor in diabetic subjects. Recent trials have suggested that blood pressure objectives should be < or = 140/80 mmHg. However, there is currently no evidence supporting any particular preferential drug strategy for this treatment objective. [less ▲]

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See detailLong-term effects of oral estradiol and dydrogesterone on carbohydrate metabolism in postmenopausal women.
Gaspard, Ulysse ULg; Wery, Olivier ULg; Scheen, André ULg et al

in Climacteric : The Journal of the International Menopause Society (1999), 2(2), 93-100

OBJECTIVE: To determine in postmenopausal women the long-term effects on carbohydrate metabolism of the administration of oral micronized 17 beta-estradiol (2 mg/day continuously) and cyclical ... [more ▼]

OBJECTIVE: To determine in postmenopausal women the long-term effects on carbohydrate metabolism of the administration of oral micronized 17 beta-estradiol (2 mg/day continuously) and cyclical dydrogesterone (10 mg/day for 14 days per 28-day cycle). METHODS: A 2-year open-label prospective, non-comparative study was carried out of 13 healthy postmenopausal women receiving cyclical estradiol and dydrogesterone and serving as their own controls. Concentrations of blood glucose, plasma insulin, C-peptide, glucagon and free fatty acids (FFAs) were determined before treatment (base-line) and at 6, 12 and 24 months of hormone replacement therapy under fasting conditions and during a standard 75-g, 3-h, oral glucose tolerance test (OGTT). RESULTS: Fasting blood glucose levels were unchanged throughout the study, and the mean areas under the curves (AUCs) for glucose response increased slightly but non-significantly versus baseline; fasting plasma insulin levels tended a decrease, and AUCs for insulin responses to the glucose load fell by 23% from baseline (not significant); fasting C-peptide levels and AUCs were unchanged; plasma glucagon fasting levels and responses were in the normal range and stable throughout the study; and plasma FFA fasting levels decreased significantly, as well as FFA AUCs during OGTTs, at the 12th and 24th months of the study. CONCLUSIONS: During a 2-year treatment with oral estradiol and cyclical dydrogesterone, a direct progesterone derivative, tolerance to glucose was unchanged, fasting plasma insulin and insulin response to repeated glucose loads were decreased, and C-peptide levels remained unchanged, indicating a potential improvement in insulin sensitivity and clearance, as in younger women; additionally, a slightly enhanced antilipolytic activity of insulin was observed. [less ▲]

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See detailThe long-term cytoskeletal rearrangement induced by rabbit enteropathogenic Escherichia coli is Esp-dependent but intimin-independent
Nougayrède, J. P.; Marchès, O.; Boury, M. et al

in Molecular Microbiology (1999), 31

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See detailBen Watson, Art, Class and Cleavage
Delville, Michel ULg

in Textual Practice (1999), 13

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See detailOn the analysis of steel structures made of thin-walled members
Degée, Hervé ULg

in Acta Polytechnica (1999), 39(5), 7-14

A first part of this paper consists in a review of the different existing methods, allowing to study the behaviour of members for which it is necessary to account for the deformability of the cross ... [more ▼]

A first part of this paper consists in a review of the different existing methods, allowing to study the behaviour of members for which it is necessary to account for the deformability of the cross section. A particular attention is paid to the capacity of each method to be used for the global analysis of a complete structure. A second part of the paper presents bases for the adaptation of a beam finite element so as to be able to account for the deformability of the profile crosse section. [less ▲]

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See detailNonprofit Organisations and Social Economy: Two Ways of Understanding the Third Sector
Mertens de Wilmars, Sybille ULg

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (1999), 70:3

The term third sector refers to a set of organizations which are neither capitalist, nor governmental. First of all, this paper aims to extent B. Gui's unitary approach to the third-sector (1991) by ... [more ▼]

The term third sector refers to a set of organizations which are neither capitalist, nor governmental. First of all, this paper aims to extent B. Gui's unitary approach to the third-sector (1991) by focusing on the distinction between third sector and state-owned bodies. Next I propose to translate the non capitalist and the non governmental conditions into operational criteria. I show that these criteria vary according to the nature of the organizations (general interest versus mutual interest). This statement allows me to justifiy the emergence of two different ways of understanding the third-sector in anglo-saxon and french-speaking traditions. [less ▲]

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See detailPériartérite noueuse en relation avec une hépatite B
Demolin, G.; Delwaide, Jean ULg; Van Severen, M. et al

in Revue Médicale de Liège (1999), 54(1), 921-924

A 66-year-old man was hospitalized for asthenia, weight loss, fever and chills. A polyarteritis nodosa associated with hepatitis B virus infection in a replicative phase was diagnosed. Etiology ... [more ▼]

A 66-year-old man was hospitalized for asthenia, weight loss, fever and chills. A polyarteritis nodosa associated with hepatitis B virus infection in a replicative phase was diagnosed. Etiology, physiopathology, and clinical characteristics of hepatitis B virus-related polyarteritis nodosa will be reviewed, as well as the effectiveness of therapy combining corticosteroids, interferon alpha and plasma exchanges. [less ▲]

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See detailIntragranular and intergranular superconducting properties of bulk melt-textured YBCO
Vanderbemden, Philippe ULg; Cloots, Rudi ULg; Ausloos, Marcel ULg et al

in IEEE Transactions on Applied Superconductivity (1999), 9(2), 2308-2311

We have investigated the superconducting properties of bulk melt-processed YBCO using different experimental techniques. First, single domain materials (i.e. containing no grain boundaries) have been ... [more ▼]

We have investigated the superconducting properties of bulk melt-processed YBCO using different experimental techniques. First, single domain materials (i.e. containing no grain boundaries) have been studied. Electrical resistivity, current-voltage characteristics, M-H loops, and A,C. susceptibility. have been measured for different field and current directions. The intragranular properties are characteristic of high-quality melt-processed YBCO material,,vith a critical current density J(c)(T=77K, B=1T//c) > 10(4) A/cm(2). The anisotropy ratio J(c)(ab)/ J(c)(c) is found to be close to 3. Both magnetic and transport measurements show that defects in the microstructure do not significantly impede the current flow inside the single domain. These results were compared to those measured on samples containing one "natural" single grain boundary which sometimes appears during the grain growth process. The intergranular properties show a much stronger current and magnetic field dependence than that measured within the grain and these differences are discussed. [less ▲]

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detailDe nouveaux acteurs dans la physiopathologie du metabolisme de l'eau: les aquaporines
Pequeux, Christel ULg; Brilot, Fabienne; Martens, Henri ULg et al

in Revue Médicale de Liège (1999), 54(11), 867-74

Aquaporins are transmembrane proteins mediating water transport across plasma membrane of animal, vegetal or bacterial cells. Among the ten aquaporins known in mammals, six are located in kidney and take ... [more ▼]

Aquaporins are transmembrane proteins mediating water transport across plasma membrane of animal, vegetal or bacterial cells. Among the ten aquaporins known in mammals, six are located in kidney and take part in urine concentration. AQP2 is vasopressin regulated, it is the only family member to be implicated in human pathology, such as nephrogenic diabetes insipidus, congestive heart failure, hepatic cirrhosis, nephrotic syndrome or SIADH. Aquaporins are expressed in a wide variety of tissues, such as brain or gastrointestinal tractus, and suggest a role in water tissue exchange, but their real function is still not define. To know the physiological impact of aquaporins, AQP1, AQP3, AQP4 and AQP5 knockout mice have been created and their phenotype analysed. [less ▲]

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