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See detailNon thermal nitrogen atoms in the earth's thermosphere. I - Kinetics of hot N(4S). II - A source of nitric oxide
Shematovich, V. I.; Bisikalo, D. V.; Gérard, Jean-Claude ULg

in Geophysical Research Letters (1991), 18

The energy distribution of translationally hot nitrogen atoms in the thermosphere has been calculated using a nonequilibrium kinetic model. Dissociation by solar EUV photons and photoelectrons is found to ... [more ▼]

The energy distribution of translationally hot nitrogen atoms in the thermosphere has been calculated using a nonequilibrium kinetic model. Dissociation by solar EUV photons and photoelectrons is found to provide an important source of non-Maxwellian high energy N(4S) atoms. It is shown that quenching of metastable N(2D) atoms by atomic oxygen also produces significant amounts of hot N(4S) atoms. The fraction of hot N atoms reacting with O2 is found to be about 15 percent of the production rate of atomic nitrogen by N2 dissociation by photon and photoelectron impact and quenching of N(2D) metastable atoms by atomic oxygen. The very fast reaction between hot N(4S) atoms and O2 is shown to provide an additional source of nitric oxide. At equatorial latitudes, this contribution amounts to 6-30 percent of the other classical production sources of NO for solar minimum activity conditions. It is concluded that the effect of hot N atoms must be considered in future models of the NO-N system chemistry. [less ▲]

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See detailThe light curves of periodic Be stars in NGC 3766
Balona, L. A.; Sterken, C.; Manfroid, Jean ULg

in Monthly Notices of the Royal Astronomical Society (1991), 252

Results of an intensive photometric campaign on four period Be stars in the southern open cluster NGC 3766 are presented as well as light curves covering the years 1985-1990. It is found that, in spite of ... [more ▼]

Results of an intensive photometric campaign on four period Be stars in the southern open cluster NGC 3766 are presented as well as light curves covering the years 1985-1990. It is found that, in spite of dramatic changes in the shapes and amplitudes of the light curves, phase locking is maintained and the period is unchanged over the five-year interval. It is concluded that within observational limits there is no evidence for coherent multiperiodicity in any of the four stars. No obvious correlation is found between the amplitudes or shapes of the light curves and the H-alpha line profiles. These findings are discussed in the light of the nonradial pulsation and starspot hypotheses, and they are shown to be observationally indistinguishable. A model in which matter is trapped in a magnetic field and forced into corotation with the star is discussed. [less ▲]

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See detailEffect of treatment with octreotide on the morphology of growth hormone secreting pituitary adenomas : study of 24 cases.
Beckers, Albert ULg; Kovacs, K.; Horvwarth, E. et al

in Endocrine Pathology (1991), 2(3), 123-131

Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological ... [more ▼]

Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8 other cases, a slight reduction in tumorsize was observed, and in 3 cases an important shrinkage was documented. At surgery, the adenomatous tissue appeared softer than in nonpretreated patients, facilitating the operation. Pathological examination revealed widening of perivascular spaces with accumulation of fibrous tissue and more crinophagy than in nonpretreated patients but failed to reveal morphologically pronounced cell involution as observed in prolactin-producing adenomas treated with dopamine agonists. No significant difference in frequency or extent of cellular changes was noted between the two groups. These morphological findings seem to be more consistent with a functional inhibition of growth hormone release than with cellular alterations induced by octreotide. [less ▲]

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See detailLiège 1866-1991 : Mutations d’un espace urbain
Frankignoulle, Pierre ULg

in Gagnez (1991)

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See detailL'immixtion de l'expertise humaine parmi les outils de gestion : l'apport des systèmes-experts
Van Caillie, Didier ULg

in La Vie au Bureau (1991)

Cet article décrit ce que sont les systèmes experts à la fin des années '80, leur intérêt en tant qu'outils de gestion additionnels et la manière dont ils permettent de valoriser l'expertise humaine en ... [more ▼]

Cet article décrit ce que sont les systèmes experts à la fin des années '80, leur intérêt en tant qu'outils de gestion additionnels et la manière dont ils permettent de valoriser l'expertise humaine en tant que capital intangible et immatériel d'une entreprise, notamment d'une PME. [less ▲]

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See detailAre Antibodies Responsible for a Decreased Superovulatory Response in Goats Which Have Been Treated Repeatedly with Porcine Follicle-Stimulating Hormone ?
Remy, Benoit; Baril, Gérard; Vallet, J. C. et al

in Theriogenology (1991), 36(3), 389-99

Repeated administration of xenogenic gonadotropins in human or animal species may be responsible for antibody production and refractoriness. An experiment was conducted in which goats were treated with ... [more ▼]

Repeated administration of xenogenic gonadotropins in human or animal species may be responsible for antibody production and refractoriness. An experiment was conducted in which goats were treated with porcine FSH (p-FSH) at 6-week intervals for a period of 7 months. A sensitive radioimmunoassay (RIA) was used to detect antibodies to p-FSH in plasma samples taken at short-term intervals during a 7-month period. Antibodies appeared after the first injection, and levels increased following booster injections. A high correlation rate existed between antibody level and superovulatory response. Refractoriness in goats was associated with a high level of antibodies. [less ▲]

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See detailTumeurs cutanées à papillomavirus. Intérêt de l'immunopathologie et de l'hybridation in situ
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Fazaa, B. et al

in Revue Médicale de Liège (1991), 46(9), 480-485

On connaît actuellement une soixantaine de papillomavirus humains. Ils sont responsables des verrues, des condylomes, de papillomes ainsi que de lésions maculeuses paucisymptomatiques. Certaines tumeux ... [more ▼]

On connaît actuellement une soixantaine de papillomavirus humains. Ils sont responsables des verrues, des condylomes, de papillomes ainsi que de lésions maculeuses paucisymptomatiques. Certaines tumeux épithéliales, localement invasices ou franchement malignes sont également le reflet d'une infection par certains de ces papillomavirus. Nous présentons une brève revue des méthodes cliniques et histologiques qui peuvent être mises en oeuvre pour le dépistage et l'identification de ces atteintes virales. [less ▲]

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See detailPhotos + annonce de Colloque International, U. Lg
Sacré, Robert ULg

in Soul Bag (1991), (124),

1) PHOTO DE COUVERTURE Johnny Heartman 2) Photos Ann PEEBLES , Otis CLAY , Lynn WHITE ; Hasselt Nov. 1989 3) Annonce de la Conférence Internationale de Septembre 1991 à l' Université de Liège ( The ... [more ▼]

1) PHOTO DE COUVERTURE Johnny Heartman 2) Photos Ann PEEBLES , Otis CLAY , Lynn WHITE ; Hasselt Nov. 1989 3) Annonce de la Conférence Internationale de Septembre 1991 à l' Université de Liège ( The secular in religious music and the sacred in secular music" [less ▲]

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See detailRectal cancer: need for radiotherapy in determining the treatment plan
Coucke, Philippe ULg; Bosset, J-F; Mirimanoff, R-O

in Helvetica Chirurgica Acta (1991), 58(3), 345-58

Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches ... [more ▼]

Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches include introduction of chemotherapy to postoperative radiotherapy or combined radiotherapeutic treatment with preoperative irradiation, surgery and intraoperative irradiation, along with elective postoperative treatment in function of surgical and pathological data. Based on recent advances in radiobiology we are able to modify treatment parameters to enhance efficacy without increasing the toxicity. The reduction of dose per fraction, the application of radiosensitizers, the optimal protection of healthy tissue will increase the therapeutic ratio while keeping results constant or even reduce the incidence of local failure. [less ▲]

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See detailAcute Amphetamine-Induced Subsensitivity of A10 Dopamine Autoreceptors in Vitro
Seutin, Vincent ULg; Verbanck, Paul; Massotte, Laurent ULg et al

in Brain Research (1991), 558(1), 141-4

Extracellular recordings were obtained from spontaneously active, presumed dopamine (DA) neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied (+)-amphetamine (AMPH ... [more ▼]

Extracellular recordings were obtained from spontaneously active, presumed dopamine (DA) neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied (+)-amphetamine (AMPH) (1-30 microM) induced a concentration-dependent decrease in the firing rate of these neurons, which tended to saturate with the highest concentrations used (n = 11). This inhibitory effect was dependent on the activation of D2 receptors since it was reversed by the D2 antagonist sulpiride (n = 8). However, the most striking effect of AMPH was the induction of a prominent subsensitivity of DA autoreceptors: whereas in 18 out of 20 control neurons, the D2 agonist BHT 920 (100 nM) produced a rapid and complete inhibition of the firing, this was observed in none out of 11 neurons 10 min after the end of the application of AMPH (1-30 microM) (P less than 0.001). In these cells, the mean percent inhibition produced by BHT 920 was only 47 +/- 8%. This subsensitivity remained unchanged after 20 min and declined after one hour. This effect was specific, since the sensitivity of GABAB receptors to baclofen (500 nM-1 microM) was not modified by the application of AMPH (n = 12). These results suggest that AMPH-induced DA autoreceptor subsensitivity can be produced acutely and may be the first step in a cascade of events leading to behavioral sensitization to this compound. [less ▲]

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See detailLes inhibiteurs de l'enzyme de conversion: la molécule a-t-elle de l'importance?
Rorive, Georges ULg; Krzesinski, Jean-Marie ULg

in Médecine et Hygiène (1991), 49

De nombreuses, peut-être de trop nombreuses molécules, dotées d'un pouvoir d'inhibition de l'enzyme de conversion ont été introduites ces dix dernières années pour le traitement de l'hypertension ... [more ▼]

De nombreuses, peut-être de trop nombreuses molécules, dotées d'un pouvoir d'inhibition de l'enzyme de conversion ont été introduites ces dix dernières années pour le traitement de l'hypertension artérielle et de l'asystolie. Les différences entre ces molécules sont peu importantes et sont fonction de leur structure moléculaire. Le captopril, seul dérivé doté d'un groupe sulfhydrile, a un effet rapide et de durée assez brève; son utilisation s'accompagne par ailleurs de certains effets secondaires propres au groupe SR. Par contre, le délai d'action des dérivés dont le ligand est un groupe carboxyle est généralement plus tardif, leur durée d'action plus longue, justifiant une prise par jour. Il reste difficile d'affirmer que le groupe SR confère des propriétés cardioprotectrices plus importantes que celles dont jouissent les autres molécules de cette classe thérapeutique. De la même manière, à ce stade, les différences démontrées concernant la diffusion tissulaire des inhibiteurs de l'enzyme de conversion n'ont pas pu être illustrées par des observations cliniques. [less ▲]

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See detailPaf-Receptor. iii. Conformational and Electronic Properties of Paf-Like Agonists and Antagonists
Lamotte-Brasseur, Josette; Dive, Georges ULg; Lamouri, Aazdine et al

in Biochimica et Biophysica Acta (1991), 1085(1), 91-105

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was ... [more ▼]

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was present in all agonists and all constrained or flexible antagonists. The distinction between agonists and antagonists appears to be casted on position-2 where the folded conformation of the substituent for agonists should be the most probable. In position-3 the gauche conformation can be adopted by all the analysed compounds. The electrostatic potential well at -30 kcal/mol stretches to the carbonyl group in position-2 in the folded conformation of the agonists. On the contrary, in constrained antagonists, a second negative zone appears around the carbamate group. Given the modelling results, the triethylammonium PAF analogue considered in literature as a weak agonist, was resynthesized and proved to be more potent than previously reported. These experimental results confirm our hypothesis in terms of a common conformation of agonist and antagonist PAF-like molecules. [less ▲]

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See detailInfrared Spectroscopic Measurements of the Vertical Column Abundance of Sulfur Hexafluoride, SF6, From the Ground
Zander, Rodolphe ULg; Rinsland, C.P.; Demoulin, Philippe ULg

in Journal of Geophysical Research (1991), 96(D8), 15447-15454

The unresolved v3 band Q branch of sulfur hexafluoride, SF6, at 947.9 cm-1 has been identified and quantitatively analyzed in series of high-quality infrared solar spectra recorded at the International ... [more ▼]

The unresolved v3 band Q branch of sulfur hexafluoride, SF6, at 947.9 cm-1 has been identified and quantitatively analyzed in series of high-quality infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, and at the National Solar Observatory facility on Kitt Peak in Arizona. Series of monthly mean total vertical column abundances of SF6 above both stations, deduced from that feature with line-by-line nonlinear least squares fitting methods, are reported over the time intervals from June 1986 to June 1990 for the Jungfraujoch and from March 1981 to June 1990 for Kitt Peak. Assuming an exponential growth model for fitting these series of measurements, it is found that the vertical column abundances have increased at mean rates of 6.9 +- 2.8 %/yr above the Jungfraujoch (calculated columns of 2.99 x 10E13 molecules/cm2 in June 1986 and 3 94 x 10E13 molecules/cm2 in June 1990) and 6.6 +- 7.2 %/yr above Kitt Peak (calculated columns equal to 2.97 x 10E13 molecules/cm2 in June 1981 and 5.38 x 10E13 molecules/cm2 in June 1990), the uncertainties corresponding to 2 sigma confidence levels. These results are further discussed within the context of variability and compared with previously published measurements. [less ▲]

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See detailAdult-like biphasic neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice
Tirelli, Ezio ULg; Jodogne, C.; Perikel, J. J.

in Brain Research. Developmental Brain Research (1991), 61(2), 207-215

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old ... [more ▼]

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old) outbred male mice. In the first experiment, relatively high doses of muscimol (ranging from 0.05 to 0.40 mg/kg in developing and from 0.50 to 3 mg/kg in adult animals) were found to dose-dependently induced solid catalepsy and ataxia, evaluated 5 times at 20-min intervals. In the second experiment, the GABA agonist was injected in dose ranges which include relatively small concentrations in order to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. It appeared that levels of rearing and especially locomotion were enhanced at the low doses (0.025 and 0.050 mg/kg in developing, and 1.3 and 1.9 mg/kg in adult mice) and inhibited at the higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). This adult-like biphasic action of muscimol in developing mice--excitation at low and depression/sedation at high doses--strongly suggests a full maturation of the GABA-A-related behavioral functions at a period of ontogeny where adult-like locomotion emerges. Given that previous studies have shown that muscimol can biphasically affect behavioral activity in newborn murines as well, it is suggested that GABA-related behavioral functions mature near-monotonically during ontogeny, unlike those related to other major neurotransmitter systems. [less ▲]

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See detailHR Carinae - A luminous blue variable surrounded by an arc-shaped nebula
Hutsemekers, Damien ULg; van Drom, E.

in Astronomy and Astrophysics (1991), 248

New high and medium dispersion spectroscopic observations of the luminous blue variable (LBV) star HR Car are presented, showing that this star has a multiple shell expanding atmosphere and undergoes ... [more ▼]

New high and medium dispersion spectroscopic observations of the luminous blue variable (LBV) star HR Car are presented, showing that this star has a multiple shell expanding atmosphere and undergoes spectral variations apparently correlated with the light variations similarly to the other LBVs. Most striking are the very broad emission wings (FWZI of about 3000 km/s) of the Balmer lines, reminiscent from the broad lines observed in the spectra of Of and WR stars. A kinematic distance of 5.4 kpc and a bolometric magnitude of -9.4 put HR Car among the most luminous stars of the Galaxy. The narrow band filter imagery also reveals an arc-shaped jet like nebula associated with HR Car. Spectroscopic observations of this nebula reveal an emission nature with very low excitation. Like the star itself, the nebula is characterized by a significant N/O overabundance, probably due to the presence of nuclear processed material ejected by the star. [less ▲]

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See detailMode of Membrane Insertion and Sequence of a 32-Amino Acid Peptide Stretch of the Penicillin-Binding Protein 4 of Enterococcus Hirae
Jacques, Philippe; el Kharroubi, Aboubaker; Van Beeumen, Jozef et al

in FEMS Microbiology Letters (1991), 66(2), 119-123

Analysis of water-soluble derivatives of the Enterococcus hirae 75-kDa membrane-bound penicillin-binding protein 4 (PBP4) has yielded the amino acid sequence of a 32-amino acid polypeptide stretch. This ... [more ▼]

Analysis of water-soluble derivatives of the Enterococcus hirae 75-kDa membrane-bound penicillin-binding protein 4 (PBP4) has yielded the amino acid sequence of a 32-amino acid polypeptide stretch. This peptide is similar to peptide segments known to occur in the N-terminal domain of high-Mr PBPs of class B. The E. hirae PBP4 probably belongs to the same class. It is anchored in the membrane at the N-terminus of the polypeptide chain. [less ▲]

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See detailStromgren six-colour photometry of SN 1987 A. I - Days 1 to 330
Helt, B. E.; Bibo, E. A.; Cuypers, J. et al

in Astronomy and Astrophysics. Supplement Series (1991), 89

Results are presented of photometric observations of SN1987A with the Danish 0.5-m telescope at La Silla for the period February 1987-January 1988, including color lines and magnitudes from day 1 to day ... [more ▼]

Results are presented of photometric observations of SN1987A with the Danish 0.5-m telescope at La Silla for the period February 1987-January 1988, including color lines and magnitudes from day 1 to day 300. For the first time, flux calibrations for H-beta passbands were derived. Included are also improved flux calibrations for the uvby passbands. [less ▲]

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See detailActive-Site Serine Mutants of the Streptomyces Albus G Beta-Lactamase
Jacob, Françoise; Joris, Bernard ULg; Frère, Jean-Marie ULg

in Biochemical Journal (1991), 277((Pt 3)), 647-52

By using site-directed mutagenesis, the active-site serine residue of the Streptomyces albus G beta-lactamase was substituted by alanine and cysteine. Both mutant enzymes were produced in Streptomyces ... [more ▼]

By using site-directed mutagenesis, the active-site serine residue of the Streptomyces albus G beta-lactamase was substituted by alanine and cysteine. Both mutant enzymes were produced in Streptomyces lividans and purified to homogeneity. The cysteine beta-lactamase exhibited a substrate-specificity profile distinct from that of the wild-type enzyme, and its kcat./Km values at pH 7 were never higher than 0.1% of that of the serine enzyme. Unlike the wild-type enzyme, the activity of the mutant increased at acidic pH values. Surprisingly, the alanine mutant exhibited a weak but specific activity for benzylpenicillin and ampicillin. In addition, a very small production of wild-type enzyme, probably due to mistranslation, was detected, but that activity could be selectively eliminated. Both mutant enzymes were nearly as thermostable as the wild-type. [less ▲]

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See detailThe Fate of Mitochondrial Dnas of Mt+ and Mt- Origin in Gametes and Zygotes of Chlamydomonas
Beckers, M. C.; Munaut, Carine ULg; Minet, Arlette ULg et al

in Current Genetics (1991), 20(3), 239-43

In order to study the mechanism responsible for the uniparental transmission of the mitochondrial genome in crosses between Chlamydomonas reinhardtii and C. smithii, we have analyzed the fate of ... [more ▼]

In order to study the mechanism responsible for the uniparental transmission of the mitochondrial genome in crosses between Chlamydomonas reinhardtii and C. smithii, we have analyzed the fate of mitochondrial DNA during gametogenesis, zygospore differentiation and sporulation by hybridization experiments. Both mt+ and mt- gametes contain the same amount of mitochondrial DNA and the two parental genomes persist for several days in the zygotes. The DNA of mt+ origin is slowly eliminated during the period of zygote maturation. Light is required for total elimination of mt+ mitochondrial DNA in the zygospores. Using appropriate restriction enzymes, we have been unable to detect methylation of the mitochondrial DNA during gametogenesis or zygospore formation. The possibility that the mt+ mitochondria themselves are specifically eliminated in the course of zygote maturation is discussed. [less ▲]

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See detailA linear-quadratic model of cell survival considering both sublethal and potentially lethal radiation damage
Rutz, HP; COUCKE, Philippe ULg; Mirimanoff, RO

in Radiotherapy & Oncology (1991), 21(4), 273-276

We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was ... [more ▼]

We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was enhanced increased exponentially with a linear and a quadratic component, namely xi and psi: RR = e xi D + psi D2. Survival of irradiated cells can thus be expressed by a combined linear-quadratic model considering four variable, namely alpha and beta for the capacity of the cells to accumulate sublethal damage, and xi and psi for their capacity to repair potentially lethal damage: SF = e(xi - alpha)D + (psi - beta)D2. [less ▲]

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See detailModulation of Proteolytic Activity During Neuritogenesis in the Pc12 Nerve Cell: Differential Control of Plasminogen Activator and Plasminogen Activator Inhibitor Activities by Nerve Growth Factor and Dibutyryl-Cyclic Amp
Leprince, Pierre ULg; Rogister, Bernard ULg; Delree, P. et al

in Journal of Neurochemistry (1991), 57(2), 665-74

Extracellular proteolysis is considered to be required during neuritic outgrowth to control the adhesiveness between the growing neurite membrane and extracellular matrix proteins. In this work, PC12 ... [more ▼]

Extracellular proteolysis is considered to be required during neuritic outgrowth to control the adhesiveness between the growing neurite membrane and extracellular matrix proteins. In this work, PC12 nerve cells were used to study the modulation of proteolytic activity during neuronal differentiation. PC12 cells were found to contain and release a 70-75-kDa tissue-type plasminogen activator (tPA) and a much less abundant 48-kDa urokinase-type plasminogen activator. A plasminogen activator inhibitor (PAI) activity with molecular sizes of 54 and 58 kDa was also detected in PC12 cell conditioned medium and formed high-molecular-mass complexes with released tPA. Release of PAI activity was dependent on treatment with nerve growth factor (NGF), whereas tPA synthesis and release were under control of a cyclic AMP-dependent mechanism and increased on treatment with dibutyryl-cyclic AMP [(But)2cAMP] or cholera toxin. Simultaneous treatment with NGF and (But)2cAMP resulted in increases of both tPA and PAI release and enhancement of tPA-PAI complex formation. The resulting plasminogen activator activity in conditioned medium was high in (But)2cAMP-treated cultures with short neuritic outgrowth but remained low in NGF- or NGF plus (But)2cAMP-treated cultures, where neurite extension was, respectively, large and very large. These results suggest that excess proteolytic activity may be detrimental to neuritic outgrowth and that not only PAI release but also tPA-PAI complex formation is associated with production of large and stable neuritic outgrowth. This can be understood as an involvement of PAI in the protection against neurite-destabilizing proteolytic activity. [less ▲]

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See detailInduction of Thymocyte Proliferation by Supernatants from a Mouse Thymic Epithelial Cell Line
Villa-Verde, Dea; Defresne, Marie-Paule ULg; Greimers, Roland ULg et al

in Cellular Immunology (1991), 136(1), 113-21

The thymic stroma plays a critical role in the generation of T lymphocytes by direct cell-to-cell contacts as well as by secreting growth factors or hormones. The thymic epithelial cells, responsible for ... [more ▼]

The thymic stroma plays a critical role in the generation of T lymphocytes by direct cell-to-cell contacts as well as by secreting growth factors or hormones. The thymic epithelial cells, responsible for thymic hormone secretion, include morphologically and antigenically distinct subpopulations that may exert different roles in thymocyte maturation. The recent development of thymic epithelial cell lines provided an interesting model for studying thymic epithelial influences on T cell differentiation. Treating mouse thymocytes by supernatants from one of TEC line (IT-76M1), we observed an induction of thymocyte proliferation and an increase in the percentages of CD4-/CD8- thymocytes. This proliferation was largely inhibited when thymocytes were incubated with IT-76M1 supernatants together with an anti-thymulin monoclonal antibody, but could be enhanced by pretreating growing epithelial cells by triiodothyronine. We suggest that among the target cells for thymulin within the thymus, some putative precursors of early phenotype might be included. [less ▲]

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See detailKainate and Nmda Toxicity for Cultured Developing and Adult Rat Spiral Ganglion Neurons: Further Evidence for a Glutamatergic Excitatory Neurotransmission at the Inner Hair Cell Synapse
Lefèbvre, Philippe ULg; Weber, T.; Leprince, Pierre ULg et al

in Brain Research (1991), 555(1), 75-83

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory ... [more ▼]

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory neurons, we show that the afferent auditory neuronal population can be divided, on the basis of its sensitivity to the neuronotoxic effect of glutamate and its analogs, in at least 3 subpopulations, one responding to N-methyl-D-aspartate (NMDA), one responding to kainate and a third minor one unresponsive to NMDA, kainic acid and glutamate. No toxic effect of quisqualate is observed. The use of specific antagonists (kynurenate and 2-amino-5-phosphonovalerate (DAP-5) demonstrates the specificity of the receptors to the excitatory amino acids on the afferent auditory neurons. Afferent auditory neurons from adult rats can also be cultured and in these preparations only the large neurons are sensitive to glutamate, kainate and NMDA while the small neurons are not responsive, suggesting that a glutamatergic neurotransmission occurs only at this synapse between the inner hair cells and the large radial afferent auditory neurons. We also show that, in vitro, the organ of Corti releases, in response to an increased potassium concentration and in the presence of calcium, a toxic activity for the afferent auditory neurons that is antagonized by kynurenate and DAP-5. Pathophysiological implications are discussed. [less ▲]

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See detailDetermination of Absolute Strengths of N2 Quadrupole Lines From High-Resolution Ground-based IR Solar Observations
Demoulin, Philippe ULg; Farmer, C.B.; Rinsland, C.P. et al

in Journal of Geophysical Research (1991), 96(D7), 13003-13008

High-resolution, high signal-to-noise ratio, solar absorption spectra recorded with a Fourier transform spectrometer at the International Scientific Station of the Jungfraujoch, Switzerland, have been ... [more ▼]

High-resolution, high signal-to-noise ratio, solar absorption spectra recorded with a Fourier transform spectrometer at the International Scientific Station of the Jungfraujoch, Switzerland, have been analyzed to determine the strengths of several lines belonging to the S branch of the N2 (1-0) electric quadrupole vibration-rotation band centered at 2329.9168 cm-1. The method which was applied here was based on equivalent width measurements of lines observed over a broad range of air masses; extrapolation of these measurements to zero air mass gave the line strengths for the transitions S7 to S10, independent of half widths, an ambiguity unavoidable with the use of curve-fitting techniques. The resulting absolute accuracies of the line strengths derived here, estimated to be better than +-2.5% for S8, +-2.6% for S10, +-3.4% for S9, and +-5.1% for S7, are due largely to the high quality and quantity of the spectra retained in this analysis and the accuracy with which the observation conditions are known. An important application of the improved values for these N2 transitions, which have low initial ground state energies, is the direct determination of the line-of-sight atmospheric air masses associated with remotely sensed infrared spectroscopic observations. Positions of the N2 transitions studied here have further been redetermined with an absolute accuracy better than 0.0002 cm-1. [less ▲]

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See detailA database of Ap stars
Renson, Pierre ULg; Kobi, D.; North, P.

in Astronomy and Astrophysics. Supplement Series (1991), 89

A database for 3195 Ap stars, which can be used on an IBM-compatible personal computer, is described. It is essentially based on Renson's general catalogue of Ap and Am stars, but contains much additional ... [more ▼]

A database for 3195 Ap stars, which can be used on an IBM-compatible personal computer, is described. It is essentially based on Renson's general catalogue of Ap and Am stars, but contains much additional information. It operates within the Dbase III Plus system. [less ▲]

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See detailCalibration of the Alpha Centauri system - Metallicity and age
Noels-Grötsch, Arlette ULg; Grevesse, Nicolas ULg; Magain, Pierre ULg et al

in Astronomy and Astrophysics (1991), 247

The binary system Alpha Cen A and B, with its well known parallax, its high quality orbit and the reasonable hypothesis of a common origin and age for both components, is a useful test of stellar ... [more ▼]

The binary system Alpha Cen A and B, with its well known parallax, its high quality orbit and the reasonable hypothesis of a common origin and age for both components, is a useful test of stellar evolution models. Evolutionary sequences are computed for 1.085 and 0.9 solar masses with different values of Z, Y and alpha (= l/Hp). Adopting luminosities and effective temperatures as derived from the observations, Z = 0.04, Y = 0.32, alpha = 1.6 and t = 5 Gyr. The Z-value derived from evolutionary sequences is very sensitive to the difference in effective temperature between the two components. [less ▲]

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See detailThe diurnal variation of NO, N(D-2), and ions in the thermosphere - A comparison of satellite measurements to a model
Rusch, D. W.; Gérard, Jean-Claude ULg; Fesen, C. G.

in Journal of Geophysical Research (1991), 96

A data base of parameters important to understanding the diurnal variation of odd-nitrogen and ions in the thermosphere near equinox, at low latitudes, and for quiet geomagnetic conditions is presented ... [more ▼]

A data base of parameters important to understanding the diurnal variation of odd-nitrogen and ions in the thermosphere near equinox, at low latitudes, and for quiet geomagnetic conditions is presented. The data base includes profiles of the odd-nitrogen species NO and N(D-2), the ions NO(+), O2(+), O(+), N2(+), and N(+); the total ion density; O and N2; and the neutral, ion, and electron temperatures. The measured time-dependent variations of NO, N(D-2), O2(+), and NO(+) compare favorably to the results of a time-dependent, photochemical, diffusion model for odd-nitrogen and ion chemistry. In particular, the model reproduces the rapid increase in NO density in the morning hours, the midafternoon maximum, and the late afternoon decrease. The model also reproduces the measured absolute densities for NO to within 20 percent over most of the diurnal cycle but falls below the measured density by as much as a factor of two in the late afternoon. [less ▲]

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See detailHD160529 - a New Galactic Luminous Blue Variable
Sterken, C.; Gosset, Eric ULg; Juttner, A. et al

in Astronomy and Astrophysics (1991), 247

The galactic early-type A hypergiant HD 160529 has been photometrically monitored in the Strömgren system during the past 18 years. HD 160529 has become fainter in the optical range by 0.5 mag during the ... [more ▼]

The galactic early-type A hypergiant HD 160529 has been photometrically monitored in the Strömgren system during the past 18 years. HD 160529 has become fainter in the optical range by 0.5 mag during the past eight years. In addition, pulsation-like variations with a quasi-period of 57 days and with a peak-to-peak amplitude of about 0.1 mag in b and y were found. The fading was not completely monotonous a fall of at least 0.2 mag in b and y within about 40 days around JD2446500 is particularly remarkable. This jump is accompanied by a change in the temperature-sensitive c[SUB]1[/SUB] index of about -0.14 mag. HD 160529 has become visually fainter and hotter during the past eight years, thus becoming a new case of a galactic Luminous Blue Variable (LBV). Model calculations on the basis of the photometry and previously published as well as new spectroscopic observations have shown HD 160529 to be a close counterpart of R 110, a recently discovered LBV in the LMC. From this comparison an absolute magnitude of M[SUB]V[/SUB] = -8.9 and a distance of 2.5 kpc is derived. The stellar parameters characterising the maximum state are estimated to be T[SUB]eff[/SUB] ≍ 8000 K, log g ≍ 0.55, R ≍ 330 R[SUB]sun[/SUB], from which the mass is estimated to be only M ≍ 13 M[SUB]sun[/SUB]. From the Hα profile a lower limit of the mass-loss rate of HD 160529 was calculated, which is about 10 times higher than that of R 110; this could be a consequence of the higher metallicity of the galactic LBV. The low mass of HD 160529 makes this luminous blue star a good candidate for a post-RSG (red supergiant phase) object, providing some evidence that (as sometimes argued) low metallicity is not a necessary prerequisite for evolution of massive stars backward to higher temperatures. [less ▲]

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See detailLa Galaxie McLuhan
Durand, Pascal ULg

in Liège-Université (1991)

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See detailAdulés, honnis,... réhabilités ? A propos des manuels scolaires
Jadoulle, Jean-Louis ULg

in Bulletin de Clio (1991), n°89

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See detailLung Fluid Dynamics and Supply Dependency of Oxygen Uptake During Experimental Endotoxic Shock and Volume Resuscitation
D'Orio, Vincenzo ULg; Mendes, P.; Carlier, Pierre ULg et al

in Critical Care Medicine (1991), 19(7), 955-62

BACKGROUND AND METHODS: We studied the effect of volume resuscitation on lung fluid balance and systemic oxygen extraction during septic shock in eight anesthetized dogs. Sepsis was induced using a 2-hr ... [more ▼]

BACKGROUND AND METHODS: We studied the effect of volume resuscitation on lung fluid balance and systemic oxygen extraction during septic shock in eight anesthetized dogs. Sepsis was induced using a 2-hr continuous infusion of Escherichia coli endotoxin at 0.25 micrograms/min.kg. Relationships between oxygen uptake (VO2) and oxygen supply (DO2) were performed acutely during stepwise controlled decrements in cardiac output by progressive inflation of an intracardiac balloon. At each stage, DO2 and corresponding VO2 were measured independently and the individual critical DO2 level was referred to as the point below which the relationship held. The slope of such a constructed relationship was defined as the maximal oxygen extraction ratio. Lung fluid balance was assessed by measurements of extravascular lung water. All values were studied at baseline, after endotoxin insult, and after reversing hypotension by a 10% dextran infusion. RESULTS: Endotoxin infusion led to a shock state that associated hypotension (from 135 to 63 mm Hg) with increases in blood lactate (from 0.53 to 3.9 mmol/L). The mean critical DO2 and maximal oxygen extraction ratio were significantly altered from 7.9 to 17.8 mL/min.kg and from 0.81 to 0.38, respectively. After reversing hypotension by 28 mL/kg colloid infusion, the critical DO2 (11.4 mL/min.kg) and maximal oxygen extraction ratio (0.48) were significantly improved. However, restoration of normal values required a state of fluid overload by further dextran infusion (8 mL/kg). At the end of the fluid challenge, extravascular lung water significantly increased from 6.4 to 17.4 mL/kg. CONCLUSIONS: These data suggest that volume loading may reverse endotoxin-induced peripheral perfusion abnormalities. However, substantial pulmonary edema may occur, possibly jeopardizing the beneficial effects of fluid expansion. [less ▲]

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See detailMystification et démystification chez Alphonse Allais
Defays, Jean-Marc ULg

in French Studies (1991), XLV(3), 279-294

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See detailRadioprotection de l'intestin grele dans le petit bassin par implantation de prothese siliconee gonflable
Cuttat, J-F; Delaloye, J-F; COUCKE, Philippe ULg et al

in Schweizerische Medizinische Wochenschrift (1991), 121(29), 1055-61

The combination of radiotherapy and surgery plays a major role in treating pelvic cancer. However, this technique is chiefly limited by the radiosensitivity of the small bowel following postoperative ... [more ▼]

The combination of radiotherapy and surgery plays a major role in treating pelvic cancer. However, this technique is chiefly limited by the radiosensitivity of the small bowel following postoperative radiotherapy. In this situation the small bowel is not protected because of its lack of mobility. A radioprotective prosthesis is presented which is readily removable and whose purpose is to push the small bowel out of the pelvis during radiotherapy, thus protecting it from radiotherapy. If required, a simple system allows the prosthesis to be emptied and refilled between courses of radiotherapy, if required, without reoperation. This technique has been used in 4 patients: 2 had rectal carcinoma secondary to ulcerative colitis in one case and to Crohn's disease in the other; the other 2 cases were recurrent rectal carcinoma, one of which was partially resectable. When radiotherapy was completed the prosthesis could be deflated and removed through a short incision under local anesthetic. In the medium term, no small bowel complications were observed in spite of high-dose radiotherapy. When used for radiosensitive pelvic tumors, this technique combines low cost and ease of use with very low morbidity and the possibility of administering high-dose radiotherapy [less ▲]

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See detailMultiple Clinical and Paraclinical Analyses of Chronic Tension-Type Headache Associated or Unassociated with Disorder of Pericranial Muscles
Schoenen, Jean ULg; Gérard, P.; De Pasqua, Victor ULg et al

in Cephalalgia : An International Journal of Headache (1991), 11(3), 135-9

Thirty-two female patients fulfilling the diagnostic criteria of chronic tension-type headache underwent multiple clinical (severity index before and after biofeedback therapy; anxiety score) and ... [more ▼]

Thirty-two female patients fulfilling the diagnostic criteria of chronic tension-type headache underwent multiple clinical (severity index before and after biofeedback therapy; anxiety score) and paraclinical (pericranial EMG levels and pressure-pain thresholds, temporalis exteroceptive silent period) assessments. Twenty-three patients (72%) had at least one increased EMG level and/or at least one decreased pain threshold and qualified for the subgroup" associated with disorder of pericranial muscles" (code 2.2.1). Nine patients (28%) were within the normal range for both investigations and would have been classified in the subgroup "unassociated with such disorder" (code 2.2.2). No significant differences were found between these two groups of patients for headache severity, anxiety, response to biofeedback therapy or duration of temporalis second exteroceptive silent period. The various clinical and paraclinical parameters were not significantly correlated to each other. It is therefore suggested that the subdivision of chronic tension-type headache in two subgroups based on pericranial EMG levels and/or pain sensitivity might be artificial. Since both of the latter and temporalis silent periods vary independently, they appear complementary in the study of tension-type headache patients and probably represent peripheral abnormalities, which are induced to varying intensities by a common central nervous system dysfunction. [less ▲]

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See detailPurification and characterization of a bovine pregnancy-associated glycoprotein
Zoli, André Pagnah; Beckers, Jean-François ULg; Wouters-Ballman, Patricia et al

in Biology of Reproduction (1991), 45(1), 1-10

A 67000 Mr bovine pregnancy-associated glycoprotein (bPAG) has been isolated from fetal cotyledons and purified to homogeneity by HPLC. The purification was monitored by a double immunodiffusion test and ... [more ▼]

A 67000 Mr bovine pregnancy-associated glycoprotein (bPAG) has been isolated from fetal cotyledons and purified to homogeneity by HPLC. The purification was monitored by a double immunodiffusion test and by RIA in conjunction with an antiserum raised against a crude fraction of placenta-specific antigens. The molecular weight of bPAG was estimated to be 67000 by SDS-PAGE. The isoelectric points (pI) of the four isoforms, determined by high-resolution analytical electrofocusing in polyacrylamide gel, were 4.4, 4.6, 5.2, and 5.4. The carbohydrate content of the bPAG consisted of approximately 10.02 +/- 1.09% neutral sugar and variant amounts of sialic acid (from 0.29 +/- 0.06% in the most basic isoform to 2.1 +/- 0.31% in the most acidic isoform). A specific antiserum was raised against the purified bPAG. A specific RIA showed that the bPAG was antigenically unrelated to BSA, alphafetoprotein (AFP), and human schwangerschafts-spezifischen (pregnancy-specific) beta 1 glycoprotein (SP1). According to some characteristics (e.g. the molecular weight), the purified bPAG may correspond to a form of the pregnancy-specific protein B previously described by Sasser and colleagues (Biol Reprod 1986; 35:936-942). [less ▲]

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See detailImmunocytochemical study of cell type distribution in the pituitary of Barbus barbus (Teleostei, Cyprindidae)
Toubeau, Gérard; Poilve, A.; Baras, Etienne et al

in General and Comparative Endocrinology (1991), 83(1), 35-47

Antisera to mammalian pituitary and placental hormones have been used to identify and localize the different cell types in the pituitary of the barbel (Barbus barbus, L.). The immunocytochemical labeling ... [more ▼]

Antisera to mammalian pituitary and placental hormones have been used to identify and localize the different cell types in the pituitary of the barbel (Barbus barbus, L.). The immunocytochemical labeling employed the immunoperoxidase technique or the immunogold silver staining procedure. Corticotrophic and prolactin cells, visualized using antisera to human adrenocorticotropic hormone and ovine prolactin (PRL), respectively, occur in the rostral pars distalis (RPD). Antisera against mammalian gonadotropins [ovine folliclestimulating hormone (FSH); bovine luteinizing hormone] or porcine growth hormone selectively cross-react with two different cell populations occupying the major part of the proximal pars distalis (PPD). Thyrotropic cells, stained by an antiserum to whole human thyroidstimulating hormone preabsorbed with porcine FSH, are scattered throughout the PPD and found amongst growth hormone and gonadotrophic cells. The majority of pars intermedia cells are stained with anti-melanophore stimulating hormone whereas the scattered PAS positive cells are revealed by both anti-ovine PRL and anti-bovine placental lactogen (or chorionic somatomammotropin). The latter antiserum also cross-reacts with the PRL cells of the RPD. Our results indicate that the distribution of the different cell types in Barbus barbus is similar to that described in other families of teleosts. This report is also the first demonstration of antigenic similarity between mammalian placental lactogen and fish prolactin. [less ▲]

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See detailNaissance et disparition des entités économiques : une analyse statistique du cas belge
Van Caillie, Didier ULg

in La Vie au Bureau (1991), 1991(Juin/Juillet), 18-23

This paper proposes and discusses some initial important statistics showing the increasing role played by young firms and very small firms in the Belgian economy. Data from the late '80s are discussed.

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See detailFailure to Infect Cats with Bovine Herpesvirus Type-4 Strain Movar 33/63
Thiry, Etienne ULg; Chappuis, G.; Bublot, M. et al

in Veterinary Record : Journal of the British Veterinary Association (1991), 128(26), 614-5

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See detailCloning and Expression in Escherichia Coli of Three Lipase-Encoding Genes from the Psychrotrophic Antarctic Strain Moraxella Ta144
Feller, Georges ULg; Thiry, M.; Arpigny, J. L. et al

in Gene (1991), 102(1), 111-5

The cloning and expression of genes from a psychrotrophic bacterium in a mesophilic host are described. Three lipase (Lip)-encoding genes (lip) from the antarctic psychrotroph, Moraxella TA144, were ... [more ▼]

The cloning and expression of genes from a psychrotrophic bacterium in a mesophilic host are described. Three lipase (Lip)-encoding genes (lip) from the antarctic psychrotroph, Moraxella TA144, were cloned by inserting Sau3AI-generated DNA fragments into the BamHI site of the pSP73 plasmid vector. To prevent heat denaturation of the gene product, the screening procedure on agar plates containing an emulsified lipid involved growing of Escherichia coli recombinant colonies at 25 degrees C followed by incubation at 0 degree C. The three recombinant (reLip) were cell-associated and differed by their respective specificity towards p-nitrophenyl esters of various aliphatic chain lengths. These cloned reLip conserved the main character of the wild-type enzymes, i.e. a dramatic shift of the optimal temperature of activity towards low temperatures and pronounced heat lability. [less ▲]

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See detailActualités en médecine de l'appareil locomoteur. Vascularité urticarienne: à propos d'un cas
Wang, François-Charles ULg; de Marneffe, Pierre; Reginster, Jean-Yves ULg et al

in Revue Médicale de Liège (1991), 46(6), 336-42

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See detailExperimental and Numerical Approaches of Contact with Friction and Wear in Large Deformation
Cescotto, Serge ULg; Charlier, Robert ULg; Bricout, J. P. et al

in European Journal of Mechanical Engineering (1991), 36(n° 2),

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See detailEfficacy of Sustained-Release Vaginal Oestriol in Alleviating Urogenital and Systemic Climacteric Complaints
Foidart, Jean-Michel ULg; Vervliet, J.; Buytaert, Ph

in Maturitas (1991), 13(2), 99-107

In a double-blind, placebo-controlled study, 109 patients suffering from local and vasomotor postmenopausal complaints were randomly assigned to treatment with either depot vaginal suppositories ... [more ▼]

In a double-blind, placebo-controlled study, 109 patients suffering from local and vasomotor postmenopausal complaints were randomly assigned to treatment with either depot vaginal suppositories containing 3.5 mg oestriol (E3) or a placebo. The treatment schedule comprised one vaginal suppository twice weekly for 3 weeks initially, followed by maintenance therapy with one vaginal suppository weekly for the 6-month study period. The effectiveness of the therapy was assessed on the basis of questionnaires (Kupperman index for vasomotor complaints and an original urogenital index for local complaints) and gynaecological examinations which included assessments of vaginal cytology, vaginal pH and Doderlein bacilli. To rule out induced endometrial proliferation, endometrial biopsies were performed in 50 women before and after the study. The vaginal depot (E3) formulation showed highly significant superiority over the placebo with respect to therapeutic effect on local urogenital complaints and alleviation of vasomotor complaints, including hot flushes. Analysis of the endometrial biopsies indicated that the monotherapy used caused no endometrial stimulation. Taking into account the minimal rate of adverse effects, the 3.5 mg E3 depot formulation studied represents a useful variant in the range of preparations available for the treatment of post-menopausal complaints. [less ▲]

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See detailCyclical Cushing's disease : a case report.
Velkeniers, B.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Pathology - Research & Practice (1991), 187(5), 603-607

A 41-year-old man with clinical Cushing's syndrome and intermittent central ACTH hypersecretion for a period of 9 1/2 years follow-up is described. Episodes of biochemical and clinical remission ... [more ▼]

A 41-year-old man with clinical Cushing's syndrome and intermittent central ACTH hypersecretion for a period of 9 1/2 years follow-up is described. Episodes of biochemical and clinical remission alternated with periods of florid Cushing's disease, characterized by circadian hyperpulsatile ACTH and cortisol secretion. Responses to metyrapone and inhibition of ACTH and cortisol hypersecretion after high dose dexamethasone during active phases of the disease favored a central origin of ACTH hypersecretion, confirmed by simultaneous bilateral venous sampling of the sinus petrosus inferior. Prolonged clinical remission followed near total anterior hypophysectomy. However, on anatomopathological examination of the pituitary neither corticotroph cell hyperplasia nor a microadenoma could be documented. The possibility of a functional ACTH hypersecretion is discussed. [less ▲]

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See detailTemporal Control of Bovine Herpesvirus Type 4 Glycoprotein Synthesis
Dubuisson, J.; Pastoret, Paul-Pierre ULg; Thiry, Etienne ULg

in Journal of General Virology (1991), 72((Pt 6)), 1429-34

The glycoprotein gp6/gp10/gp17, gp11/VP24 and gp8 are major bovine herpesvirus type 4 antigens. The temporal expression of these glycoproteins was studied and it was shown that gp6/gp10/gp17 appeared as ... [more ▼]

The glycoprotein gp6/gp10/gp17, gp11/VP24 and gp8 are major bovine herpesvirus type 4 antigens. The temporal expression of these glycoproteins was studied and it was shown that gp6/gp10/gp17 appeared as early as 6 h post-inoculation (p.i.), and gp11/VP24 and gp8 were detected 8 h p.i. Moreover, a precursor of two components of gp6/gp10/gp17 glycoprotein [p(gp10/gp17)] was a beta-gamma protein, whereas the gp11/VP24 and gp8 glycoproteins were gamma proteins. [less ▲]

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See detailTgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons
Lefebvre, P. P.; Staecker, H.; Weber, T. et al

in Neuroreport (1991), 2(6), 305-8

Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular ... [more ▼]

Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular receptors for bFGF in several cell types. In this study, we show that TGFss1 is expressed in cultured adult mouse auditory neurons in response to explanation injury and acts in an autocrine fashion to increase the level of expression of bFGF receptors message in these same neurons. Based on these in-vitro results, we propose that these trophic factors (i.e. TGFss1 and bFGF) play a significant role in the response to injury by the mature auditory system. [less ▲]

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See detailInceste et abus de pouvoir
Glowacz, Fabienne ULg

in Perspectives : Revue sur les Enjeux Sociaux des Pratiques Psychologiques (1991), 18

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See detailPhotosensitized Production of Singlet Oxygen by Merocyanine 540 Bound to Liposomes
Hoebeke, Maryse ULg; Piette, Jacques ULg; van de Vorst, A.

in Journal of Photochemistry and Photobiology B : Biology (1991), 9(3-4), 281-94

The production of singlet oxygen by merocyanine 540 was studied in dimyristoyl-phosphatidylcholine liposomes using two singlet oxygen probes: 9,10-anthracenedipropionic acid (water soluble) and 9,10 ... [more ▼]

The production of singlet oxygen by merocyanine 540 was studied in dimyristoyl-phosphatidylcholine liposomes using two singlet oxygen probes: 9,10-anthracenedipropionic acid (water soluble) and 9,10-dimethylanthracene (liposoluble). Upper and lower limits of singlet oxygen quantum yield for bound merocyanine 540 were determined to be 0.055 and 0.015 respectively. The diffusion characteristics of singlet oxygen were examined using the isotropic enhancement effect of D2O and the inhibitory effect of sodium azide. It was shown that 1O2 spent more than 87% of its lifetime in a vesicle environment. When the singlet-reacting substrate and the dye were both located in the bilayer, approximately 40% of the singlet oxygen remained in the liposomes where it was originally generated. [less ▲]

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See detailQuantitative Buffy Coat Analysis Related to Adrenocortical Function in Horses During a Three-Day Event Competition
Linden, Annick ULg; Art, Tatiana ULg; Amory, Hélène ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1991), 38(5), 376-82

This study was carried out to investigate stress induced in a cross-country by measuring plasma cortisol and to compare the changes in cortisol level with the leucocytic changes measured with the ... [more ▼]

This study was carried out to investigate stress induced in a cross-country by measuring plasma cortisol and to compare the changes in cortisol level with the leucocytic changes measured with the quantitative buffy coat (QBC) analysis, which is a new method applicable in field conditions for the evaluation of haematological parameters in horses. Seven healthy horses competing in a national three-day event were investigated. Venous blood was sampled under resting condition, 2 min and 180 min after the completion of the cross-country and analysed for haematological parameters, plasma cortisol, protein and lactate levels. Immediately after the event, there was a significant increase in all values except in the granulocytes (Gr) to lymphocytes-monocytes (LM) ratio. 180 min after the event, all the parameters returned to their resting levels while white blood cells (WBC), Gr and Gr/LM ratio were significantly higher with respect to their resting values. A high correlation (r = 0.82) was found between the relative increase in plasma cortisol levels 2 min after exercise and the relative increase in Gr/LM 180 min after exercise. Therefore it was concluded that the Gr/LM ratio measured 180 min after exercise with the QBC analysis is a reliable index to estimate the plasma cortisol levels measured 2 min after exercise. This new technique could consequently be used in order to evaluate, in field conditions, the exercise-induced stress. [less ▲]

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See detailExpression of Laminin by Human Fibroblasts, Ht1080 Fibrosarcoma Cells and Mcf-7 Breast Adenocarcinoma Cells. Lack of Regulation by the Cell Density and Extracellular Matrix
Munaut, Carine ULg; Noël, Agnès ULg; Sobel, M. et al

in Cell Biology International Reports (1991), 15(6), 499-509

We have cultured normal fibroblasts, fibrosarcoma HT1080 cells and breast adenocarcinoma MCF-7 cells on various substrates (plastic, collagen type I, laminin). All cell types used adhered on the three ... [more ▼]

We have cultured normal fibroblasts, fibrosarcoma HT1080 cells and breast adenocarcinoma MCF-7 cells on various substrates (plastic, collagen type I, laminin). All cell types used adhered on the three substrates with, however, a delayed attachment on laminin. On all substrates, cell grew as monolayer with the exception of MCF-7 cells that formed clusters on laminin. The epithelial MCF-7 cells as well as mesenchymal cells (fibroblasts and tumoral HT1080 cells) synthesized laminin and expressed mRNA coding for laminin B1 chain and for the 67 kD laminin binding protein. The levels of these mRNAs were not modulated by culture conditions which affect cell morphology nor by cell density. [less ▲]

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See detailNucleotide Sequence of the Lipase Gene Lip2 from the Antarctic Psychrotroph Moraxella Ta144 and Site-Specific Mutagenesis of the Conserved Serine and Histidine Residues
Feller, Georges ULg; Thiry, M.; Gerday, Charles ULg

in DNA & Cell Biology (1991), 10(5), 381-8

The lip2 gene from the antarctic psychotroph Moraxella TA144 was sequenced. The primary structure of the Lip2 preprotein deduced from the nucleotide sequence is composed of 433 amino acids with a ... [more ▼]

The lip2 gene from the antarctic psychotroph Moraxella TA144 was sequenced. The primary structure of the Lip2 preprotein deduced from the nucleotide sequence is composed of 433 amino acids with a predicted Mr of 47,222. This enzyme contains a Ser-centered consensus sequence and a conserved His-Gly dipeptide found in most lipase amino-terminal domains. These sequences are involved in the lipase active site conformation since substitution of the conserved Ser or His residues by Ala and Gln, respectively, results in the loss of both lipase and esterase activities. Structural factors that would allow proper enzyme flexibility at low temperatures are discussed. It is suggested that only subtle changes in the primary structure of these psychrotrophic enzymes can account for their ability to catalyze lipolysis at temperatures close to 0 degrees C. [less ▲]

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See detailMacromolecular engineering of polylactones and polylactides. 5. Synthesis and characterization of diblock copolymers based on poly-ε-caprolactone and poly(L,L or D,L)lactide by aluminum alkoxides
Jacobs, C.; Dubois, Philippe; Jérôme, Robert ULg et al

in Macromolecules (1991), 24(11), 3027-3034

Aluminum isopropoxide is known to be an effective initiator for the ring-opening polymerization of lactides (D,L and L,L) and epsilon-caprolactone (epsilon-CL). For a question of mutual reactivity, the ... [more ▼]

Aluminum isopropoxide is known to be an effective initiator for the ring-opening polymerization of lactides (D,L and L,L) and epsilon-caprolactone (epsilon-CL). For a question of mutual reactivity, the sequential polymerization of these two comonomers can only be achieved when epsilon-CL is first polymerized followed by the lactide. Formation of a large amount of homo PLA is however observed and has been attributed to a great difference in the mean degree of association of aluminum alkoxides in toluene in the presence of epsilon-CL and LA. In toluene, the mean number (n) of active sites per Al(O(i)Pr)3 molecule jumps from 1 to 3 when epsilon-CL is substituted by LA. The addition of a small amount of an alcohol, like 2-propanol, is effective in preventing the aluminum alkoxide from associating, and n is then 3 whatever the monomer used. 2-Propanol participates in the polymerization of epsilon-CL and LA as supported by a decrease in the molecular weight of the final polymer in relation to the molar amount of added alcohol. This means that the alcohol molecules are rapidly exchanged with the alkoxide groups on Al. Under such conditions, the formation of pure diblock copolymers P(epsilon-CL-b-LA) is reported. Another successful strategy for the synthesis of the diblock copolymer consists in using an Al derivative that bears only one alkoxide group to initiate the polymerization of the two cyclic esters. In this regard, a diethylaluminum alkoxide is of great value, particularly the ethoxide one. A third, conceptually similar, approach to the synthesis of P(epsilon-CL-b-LA) copolymers relates to the reaction of a performed hydroxy-terminated PCL with triethylaluminum and the use of that macroinitiator in the ring-opening polymerization of the lactide. [less ▲]

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See detailGround-Based Infrared Measurements of HNO3 Total Column Abundances: Long-Term Trend and Variability
Rinsland, C.P.; Zander, Rodolphe ULg; Demoulin, Philippe ULg

in Journal of Geophysical Research (1991), 96(D5), 9379-9389

The long-term trend and variability of the total column amount of atmospheric nitric acid (HNO3) have been investigated based on time series of infrared solar absorption spectra recorded at two remote ... [more ▼]

The long-term trend and variability of the total column amount of atmospheric nitric acid (HNO3) have been investigated based on time series of infrared solar absorption spectra recorded at two remote high-altitude sites, the International Scientific Station of the Jungfraujoch (ISSJ) in the Swiss Alps (altitude 3.6 km, latitude 46.5°N, longitude 8.0°E) and the National Solar Observatory McMath solar telescope facility on Kitt Peak (altitude 2.1 km, latitude 31.9°N, longitude 111.6°W), southwest of Tucson, Arizona. The HNO3 v5 band Q branch at 879.1 cm-1 and three P branch manifolds near 869 cm-1 were analyzed using a nonlinear least squares spectral fitting technique and a consistent set of spectroscopic line parameters. The ISSJ measurements evaluated in the present work consist of two solar spectra recorded with a grating spectrometer in June 1951 and a set of observations obtained with a high-resolution Fourier transform spectrometer between June 1986 and June 1990. The modern ISSJ measurements show a ~20% peak-to-peak amplitude seasonal cycle with a winter maximum superimposed on significant variability and a summer minimum; the June results from 1986 to 1990 are both higher and lower than the two retrieved June 1951 HNO3 total column amounts. The fitted trend, (-0.16 +- 0.50) %/yr, 2 sigma, indicates that there has been no detectable change in the HNO3 total column over the last 4 decades. The Kitt Peak measurements, recorded with a high-resolution Fourier transform spectrometer between December 1980 and June 1990, also show marked variability in the HNO3 total column, but in contrast to the ISSJ measurements, no obvious seasonal cycle is observed. The deduced trend in the total column above Kitt Peak, (-0.8 +- 1.6) %/yr, 2 sigma, is consistent with the ISSJ time series of measurements, in that no significant HNO3 long-term trend has been found. The sets of measurements from the two sites are compared with each other and with previously published results, with emphasis on the reported variability of HNO3 and the changes in the HNO3 total column with season and latitude. [less ▲]

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See detailA standard numbering scheme for the class A beta-lactamases
Ambler, R. P.; Coulson, A. F. W.; Frère, Jean-Marie ULg et al

in Biochemical Journal (1991), 276(Pt 1), 269-270

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See detailEconomic and Production Repercussions of Deworming by Pulse Release Device and Oral Suspension in Grazing Double-Muscled Fattening Cattle
Genicot, Bruno; Mouligneau, Frédéric; Lekeux, Pierre ULg

in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1991), 38(3), 238-240

In this field trial, the repercussions of 2 administration forms of oxfendazole, namely a single administration of a front-loaded device (group 1; n = 18) and a repeated administration of a 90.6 per cent ... [more ▼]

In this field trial, the repercussions of 2 administration forms of oxfendazole, namely a single administration of a front-loaded device (group 1; n = 18) and a repeated administration of a 90.6 per cent oral suspension (group 2; n = 18), were compared in first season-grazing double-muscled fattening bulls. The comparison was based on the production performances, the mean worm egg counts and the product- and labour-costs. The daily body gains determined on the whole trial period, i.e. 1.312 +/- 0.055 kg and 1.270 +/- 0.056 kg for groups 1 and 2 respectively, and mean worm egg counts per gram (on days 0 and 130:200.0 +/- 44.3 and 94.4 +/- 27.4 for group 1; 366.7 +/- 98.4 and 100.0 +/- 33.6 for group 2) did not differ significantly between the two groups. However, the total costs were lower with a front-loaded device (1,021 Belgian Francs) than with oral suspension (1,248 Belgian Francs per bull). [less ▲]

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See detailEmg Activity in Pericranial Muscles During Postural Variation and Mental Activity in Healthy Volunteers and Patients with Chronic Tension Type Headache
Schoenen, Jean ULg; Gérard, P.; De Pasqua, Victor ULg et al

in Headache (1991), 31(5), 321-4

EMG activity was recorded over frontalis, temporalis and trapezius muscles in a supine position, a standing position and during a mental task in 32 female patients suffering from chronic tension-type ... [more ▼]

EMG activity was recorded over frontalis, temporalis and trapezius muscles in a supine position, a standing position and during a mental task in 32 female patients suffering from chronic tension-type headache and in 20 healthy volunteers. Measurements in patients were made before and after biofeedback therapy. All EMG levels were on average significantly higher in patients than in controls. 62.5% of patients had at least one abnormal EMG level, but only 34% were beyond the normal range, if 1 muscle and 1 recording condition was considered. EMG levels were not correlated with headache severity, anxiety or response to biofeedback treatment. It is therefore suggested that pericranial EMG activity is not pathogenetic in chronic tension type headache, but merely one of several pathophysiologic changes, that are produced by a central dysfunction. [less ▲]

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See detailEconomic and Production Consequences of Liver Fluke Disease in Double-Muscled Fattening Cattle
Genicot, Bruno; Mouligneau, Frédéric; Lekeux, Pierre ULg

in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1991), 38(3), 203-208

The frequency of liver fluke disease in fattening units was determined by the analysis of random faeces samples issued from 1,513 Belgian White Blue bulls aged from 5 to 7 months and weighing from 200 to ... [more ▼]

The frequency of liver fluke disease in fattening units was determined by the analysis of random faeces samples issued from 1,513 Belgian White Blue bulls aged from 5 to 7 months and weighing from 200 to 300 kg. 12.5% of the investigated bulls were positive for liver fluke disease. These bulls were spread over 56.5% of the investigated fattening units. Furthermore the infestation rate varied from 0 to 33.3% inside the fattening units. In order to assess the economic consequences of bovine fascioliasis in double-muscled cattle and the beneficial effects of a treatment against such a disease, a trial including 30 Belgian White Blue bulls, weighing 365 +/- 9 kg and aged from 10 to 12 months, was conducted in a selected fattening unit. On the basis of faecal examinations, the 30 animals were subdivided in negative (group A; n = 10) and positive animals (n = 20) for fascioliasis, the latter being either treated with nitroxinil (group B; n = 10) or not (group C; n = 10) on day 0 of this trial which was conducted during 75 days. The daily body gains in group C (1.661 +/- 0.140 kg) were significantly lower than those in group A (1.975 +/- 0.120 kg). On the other hand there was no significant difference between the daily body gains registered in group B (1.960 +/- 0.085 kg) and A. The estimated financial loss, due to flukes and accounted on a 75 day-period, averaged 2,748 Belgian Francs per bull in group C.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailBiosynthesis of the 67 kDa high affinity laminin receptor.
Castronovo, Vincenzo ULg; Claysmith, A. P.; Barker, K. T. et al

in Biochemical and Biophysical Research Communications (1991), 177(1), 177-83

High affinity interactions between cells and laminin are mediated, at least in part, by the 67 kDa laminin receptor (67 LR). A 37 kDa nascent polypeptide (37 LRP), predicted by a full length cDNA clone ... [more ▼]

High affinity interactions between cells and laminin are mediated, at least in part, by the 67 kDa laminin receptor (67 LR). A 37 kDa nascent polypeptide (37 LRP), predicted by a full length cDNA clone and obtained by in vitro translation of hybrid-selected laminin receptor mRNA, has been immunologically identified in cancer cell extracts as the putative precursor of the 67 LR. In this study, we used affinity purified antibodies developed against cDNA-deduced 37 LRP synthetic peptides in pulse chase experiments and demonstrated a precursor-product relationship between the 37 LRP and the 67 LR. Immunoblot, pulse chase and immunofluorescence experiments showed that transient transfection of the full length 37 LRP cDNA clone induced a dramatic increase in the synthesis of the 37 LRP but not of the mature 67 LR. We propose that the 67 LR results from the association of two gene products: the 37 LRP and a polypeptide yet to be identified. [less ▲]

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See detailDéveloppement embryonnaire caprin in vitro: étude des conditions de culture
Fieni, Francis; Buggin, M.; Tainturier, Daniel et al

in Recueil de Médecine Vétérinaire (1991), 167(5), 435-444

Three culture Media: PBS; HAM F10 and B2 Menezo were used to compare and study the in vitro development of goats embryos. After 48h of culture in these media, the rate of Morulas developed was o%, 19% and ... [more ▼]

Three culture Media: PBS; HAM F10 and B2 Menezo were used to compare and study the in vitro development of goats embryos. After 48h of culture in these media, the rate of Morulas developed was o%, 19% and 42% respectively, and that of blastocysts was 25%, 73% and 95%. The B2 Menezo medium would therefore appear well adapted to the culture of blastocysts. The morulas, however, irrespective of the medium used showed limited development. [less ▲]

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See detailComparison of Proteins of Simian Herpesvirus Aotus Type 2 and Bovine Herpesvirus Type 4
Dubuisson, J.; Danyi, Sophie ULg; Bublot, M. et al

in Journal of General Virology (1991), 72((Pt 5)), 1145-50

Genomes of herpesvirus aotus type 2 (HVA-2) and bovine herpesvirus type 4 (BHV-4) have previously been shown to be closely similar. Moreover, preliminary serological data indicated that HVA-2 is ... [more ▼]

Genomes of herpesvirus aotus type 2 (HVA-2) and bovine herpesvirus type 4 (BHV-4) have previously been shown to be closely similar. Moreover, preliminary serological data indicated that HVA-2 is antigenically related to BHV-4. To extend this study, structural components of four BHV-4 strains and HVA-2 were compared by SDS-PAGE, radioimmunoprecipitation and Western blotting. The overall pattern of structural proteins was the same for HVA-2 and BHV-4 but variations were observed in electrophoretic profiles of glycoproteins, mainly of the two major ones (gp6/gp10/gp17 and gp11/VP24). Variations between HVA-2 and BHV-4 glycoproteins were greater than those observed among BHV-4 strains. [less ▲]

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See detailBlood Magnesium Levels in Migraine
Schoenen, Jean ULg; Sianard-Gainko, J.; Lenaerts, M.

in Cephalalgia : An International Journal of Headache (1991), 11(2), 97-9

Serum and erythrocyte magnesium levels were screened between attacks in patients with migraine without aura (n = 38) and with aura (n = 6), and for comparison in a group of patients suffering from chronic ... [more ▼]

Serum and erythrocyte magnesium levels were screened between attacks in patients with migraine without aura (n = 38) and with aura (n = 6), and for comparison in a group of patients suffering from chronic tension-type headache (n = 25) as well as a group of neurological, non-headache patients (n = 19). Serum magnesium levels were not significantly different between the four groups of patients. In contrast, magnesium in erythrocytes was on average significantly reduced in patients with migraine without aura compared to the other groups. It is hypothesized that this reduction might be due to an abnormal regulation of intracellular magnesium possibly reflecting at the periphery changes observed in the brain of migraineurs. [less ▲]

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See detailPlasma Vitamin E, Total Lipids and Myeloperoxidase Levels During Spinal Surgery. A Comparison between Two Anesthetic Agents: Propofol and Isoflurane
Hans, Pol ULg; Canivet, Jean-Luc ULg; Pincemail, Joël ULg et al

in Acta Anaesthesiologica Scandinavica (1991), 35(4), 302-5

Plasma levels of vitamin E (Vit. E), total lipids (TL), Vit. E to TL ratio and myeloperoxidase (MPO) were studied in 20 patients undergoing lumbar spinal surgery and randomly allocated to two anesthetic ... [more ▼]

Plasma levels of vitamin E (Vit. E), total lipids (TL), Vit. E to TL ratio and myeloperoxidase (MPO) were studied in 20 patients undergoing lumbar spinal surgery and randomly allocated to two anesthetic groups: propofol (bolus dose + continuous infusion and thiopental/isoflurane. Peripheral blood samples were withdrawn prior to induction, each hour during anesthesia and 1 h after the end of surgery. Mean Vit. E and TL levels as well as mean Vit. E to TL ratios remained in the normal range over the entire period of study whatever the anesthetic regimen. MPO levels rose significantly in the post-operative period only, but without statistical difference between the two groups. Therefore, anesthesia with propofol or thiopental/isoflurane modifies neither total lipid concentrations nor plasma Vit. E, which is a potent endogenous inhibitor of lipid peroxidation bound to lipoproteins. The rise of plasma MPO suggests a moderate post-operative neutrophil activation which is not influenced by anesthetic techniques. [less ▲]

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See detailExteroceptive Silent Period of Temporalis Muscle in Menstrual Headaches
Schoenen, Jean ULg; Bottin, D.; Sulon, J. et al

in Cephalalgia : An International Journal of Headache (1991), 11(2), 87-91

The second exteroceptive silent period (ES2) of temporalis muscle was recorded on days 1 and 15 of the menstrual cycle in 17 women, 9 of whom suffered regularly from tension-type headaches during ... [more ▼]

The second exteroceptive silent period (ES2) of temporalis muscle was recorded on days 1 and 15 of the menstrual cycle in 17 women, 9 of whom suffered regularly from tension-type headaches during menstruation. Mean duration of temporalis ES2 was significantly shorter on day 1 of the cycle than on day 15. This difference was due to a marked menstrual reduction of ES2 in the headache subgroup. A positive correlation was found between ES2 durations and oestradiol/progesterone ratios. We hypothesize that the variations of ES2 during the ovarian cycle result from the modulatory effects of oestrogens on descending aminergic pathways that control excitability of inhibitory brainstem interneurons mediating exteroceptive suppression of jaw-closing motoneurons. [less ▲]

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See detailLes auto-anticorps et le profil immunopathologique des lupus érythémateux
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1991), 46(5), 279-285

Nous présentons une synthèse de la signification diagnostique, clinique et pronostique d'une série d'auto-anticorps apparaissant dans les diverses formes de lupus érythémateux.

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See detailMacromolecular engineering of polylactones and polylactides. 4. Mechanism and kinetics of lactide homopolymerization by aluminum isopropoxide
Dubois, Philippe; Jacobs, R.; Jérôme, Robert ULg et al

in Macromolecules (1991), 24(9), 2266-2270

Aluminum isopropoxide is an effective initiator for the polymerization of lactides in toluene at 70-degrees-C. The ring-opening polymerization proceeds through a "coordination-insertion" mechanism and ... [more ▼]

Aluminum isopropoxide is an effective initiator for the polymerization of lactides in toluene at 70-degrees-C. The ring-opening polymerization proceeds through a "coordination-insertion" mechanism and selective rupture of the acyl oxygen bond of the monomer. A kinetic study has shown that the polymerization is first order in both the monomer and initiator. The polymerization is typically "living" until a molecular weight of ca. 90 000 is reached. At higher temperatures (100-degrees-C), inter- and intramolecular transesterification reactions are responsible for a limitation in the molecular weight of the growing chains. In toluene, at 70-degrees-C, each alkoxide of the aluminum isopropoxide participates in the polymerization. Any molecular weight below 90 000 can accordingly be predicted on the basis of the monomer/Al molar ratio, and the polydispersity is rather narrow (1.1-1.4). [less ▲]

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See detailEffects of Growth on Functional and Morphological Echocardiographic Variables in Friesian Calves
Amory, Hélène ULg; Lekeux, Pierre ULg

in Veterinary Record : Journal of the British Veterinary Association (1991), 128(15), 349-54

For echocardiography to become a reliable tool for the diagnosis, monitoring and prognosis of cardiac diseases in cattle, it is necessary to determine normal values of echocardiographic variables and ... [more ▼]

For echocardiography to become a reliable tool for the diagnosis, monitoring and prognosis of cardiac diseases in cattle, it is necessary to determine normal values of echocardiographic variables and their changes during the growth of healthy animals. In this study, 53 echocardiographic protocols were collected from 17 healthy Friesian calves during their period of growth. The protocol consisted of the measurement or calculation of 10 dimensional and six functional variables from M-mode long axis views of the heart. The relationships between these variables and age, body-weight and body surface area were analysed. Most of the dimensional parameters increased significantly with body size and were best predicted by an allometric regression. However, the functional indices did not change with growth, and the normal values obtained in this study may be applied to calves of any body weight. [less ▲]

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See detailThe very massive star HDE269676 and its components
Heydari-Malayeri, M.; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1991), 244

It is shown that one of the most luminous stars of the LMC, HDE269676, is in fact a massive star cluster. On the basis of observations with the ESO New Technology Telescope (NTT) the main components of ... [more ▼]

It is shown that one of the most luminous stars of the LMC, HDE269676, is in fact a massive star cluster. On the basis of observations with the ESO New Technology Telescope (NTT) the main components of the cluster are classified and it is shown that there are several O type stars in HDE269676 instead of the one or two previously known. This is interesting for the initial mass function in the LMC and implies that the number of O type stars in the LMC is generally underestimated. The most massive star of the system being about a factor three less luminous than previously estimated is a super-giant O5f with a zero age main sequence mass of about 80 solar. [less ▲]

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See detailAbundances of neutron capture elements in metal-poor dwarfs. I - Yttrium and zirconium
Zhao, G.; Magain, Pierre ULg

in Astronomy and Astrophysics (1991), 244

The yttrium and zirconium abundances are determined in a sample of 20 metal-poor stars on the basis of high resolution, high SNR spectra. Significant differences between the behaviors of these two ... [more ▼]

The yttrium and zirconium abundances are determined in a sample of 20 metal-poor stars on the basis of high resolution, high SNR spectra. Significant differences between the behaviors of these two neighboring elements are found, zirconium being less deficient than yttrium in Population II stars. Moreover, there is a genuine cosmic scatter in the abundances of these two elements relative to iron, of the order of 20 percent. The scatter is lower when these elements are compared to titanium, which might indicate that a significant fraction of the lighter neutron-capture elements are produced in massive stars. [less ▲]

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See detailAdenohypophysis hormone gene products in 14 pituitary adenomas: analysis by immunohistochemistry and northern blotting.
Scippo, Marie-Louise ULg; Beckers, Albert ULg; Frankenne, Francis ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1991), 99(2), 135-140

We investigated 14 pituitary adenomas (10 silent adenomas; 3 prolactinomas and one GH-secreting tumor) for the presence of hormone gene transcripts (Northern blot) as well as for translation products ... [more ▼]

We investigated 14 pituitary adenomas (10 silent adenomas; 3 prolactinomas and one GH-secreting tumor) for the presence of hormone gene transcripts (Northern blot) as well as for translation products (immunohistochemistry). The GH-secreting tumor was shown to express the genes coding for GH and PRL and to synthesize the corresponding hormones. In the cases of prolactinomas, immunohistochemical data demonstrated the synthesis of prolactin only. In addition to the PRL gene, Northern blot analysis revealed the transcription of the alpha-subunit gene in one case. Hormone genes were found to be expressed in 7 out of the 10 silent tumors, whereas no hormone synthesis was detected in any of these tissues. LH-beta mRNA was found in 3 cases, FSH-beta mRNA in 5 cases and alpha-subunit gene was shown to be expressed in one case. Surprisingly, the level of expression of the FSH-beta-gene was higher than in normal tissue. This study confirms that some so called << silent >> adenomas are expressing alpha- and/or beta-subunit glycoprotein hormone genes, even if no hormone is synthesized. The therapeutic action of bromocriptine described in some << silent >> adenomas cases could be related to that hormone gene expression potentiality. [less ▲]

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See detailTransfert des insulines U40 aux insulines U100: comparaison des profils insulinémiques et glycémiques chez le patient diabétique
Scheen, A. J.; Guiot, Julien; Stassen, M. P. et al

in Revue Médicale de Liège (1991), 46(4), 181-7

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See detailLa définition du produit, premier pas dans la mise en place d'un plan marketing réussi pour la petite et moyenne entreprise débutante
Van Caillie, Didier ULg

in La Vie au Bureau (1991), 1991(Avril), 47-53

This paper describes and discusses why it's important to elaborate a precise and detailed definition of a product when trying to elaborate a winning marketing plan in an emerging SME

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See detailAt the Cutting Edge. Biosynthesis and Paracrine/Cryptocrine Actions of 'Self' Neurohypophysial-Related Peptides in the Thymus
Geenen, Vincent ULg; Robert, F.; Martens, Henri ULg et al

in Molecular & Cellular Endocrinology (1991), 76(1-3), 27-31

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See detailSeasonal Cycle and Secular Trend of the Total and Tropospheric Column Abundance of Ethane Above the Jungfraujoch
Ehhalt, D.H.; Schmidt, U.; Zander, Rodolphe ULg et al

in Journal of Geophysical Research (1991), 96(D3), 4985-4994

Total column abundances of ethane (C2H6) above the Jungfraujoch Station, Switzerland, 3.58-km altitude, have been deduced from infrared solar spectra recorded in 1951 and from 1984 to 1988. The results ... [more ▼]

Total column abundances of ethane (C2H6) above the Jungfraujoch Station, Switzerland, 3.58-km altitude, have been deduced from infrared solar spectra recorded in 1951 and from 1984 to 1988. The results were derived from the spectroscopic analysis of the v7 band PQ3, PQ1, and RQ0 subbranches of C2H6 near 2976.8, 2983.4, and 2986.7 cm-1, respectively. The 1984-1988 results obtained from more than 300 observations at 0.005 cm-1 resolution show a definite seasonal variation in the total vertical column abundance of that gas, with a maximum of (1.43 +- 0.03) x 10E16 molecules/cm2 during March and April and a minimum in the fall. The corresponding C2H6 mixing ratio in the free troposphere was derived to 1.53 +- 0.14 ppb in early April; the ratio of maximum to minimum C2H6 concentration in the troposphere was found to be 1.88 +- 0.12. From the analysis of the same spectral features observed in March and April 1951, we have deduced a total vertical column abundance of (1.09 +- 0.10) x 10E16 molecules/cm2. Assuming an exponential increase with time and correcting for a small decrease in the stratospheric amount of C2H6 due to the man-induced increase in stratospheric chlorine, we obtain a secular trend in the tropospheric burden above the Jungfraujoch equal to (0.85 +- 0.3)%/yr. It is argued that this trend is valid for the entire northern hemisphere. [less ▲]

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See detailGrafts of Syngenic Cultured, Adult Dorsal Root Ganglion-Derived Schwann Cells to the Injured Spinal Cord of Adult Rats: Preliminary Morphological Studies
Martin, Didier ULg; Schoenen, Jean ULg; Delree, P. et al

in Neuroscience Letters (1991), 124(1), 44-8

Highly enriched cultures of Schwann cells were obtained from adult rat dorsal root ganglia and implanted (5 x 10(5) -9 x 10(5) cells) in the spinal cord of syngenic adult rats at the site of an acute ... [more ▼]

Highly enriched cultures of Schwann cells were obtained from adult rat dorsal root ganglia and implanted (5 x 10(5) -9 x 10(5) cells) in the spinal cord of syngenic adult rats at the site of an acute compression lesion produced by a subdural inflatable microballoon. These autografts survived and invaded the host tissue, reducing central cavitation and astrocytic gliosis. They dramatically promoted ingrowth of axons, the majority of which appeared to come from the dorsal roots as judged by their neuropeptide content. Invasion of the transplants by descending, e.g. aminergic fibers, was negligible at survival times of up to 4 months. Nonetheless, autologous Schwann cells, which are readily available in the host, represent a promising material for grafts into the injured spinal cord. [less ▲]

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See detailMacromolecular Engineering of polylactones and polylactides. 3. Synthesis, characterization and applications of poly(ε-caprolactone) macromonomers
Dubois, Philippe; Jérôme, Robert ULg; Teyssié, Philippe

in Macromolecules (1991), 24(5), 977-981

Well-defined omega-methacryloylpoly(epsilon-caprolactone) (or PCL) macromonomers have been prepared by using an aluminum alkoxide that bears a methacrylic double bond. The initiator results from the ... [more ▼]

Well-defined omega-methacryloylpoly(epsilon-caprolactone) (or PCL) macromonomers have been prepared by using an aluminum alkoxide that bears a methacrylic double bond. The initiator results from the equimolar reaction of triethylaluminum with 2-hydroxyethyl methacrylate (HEMA). The coordination-insertion type of polymerization is living and yields exclusively linear macromonomers of a predictable molecular weight with a narrow molecular weight distribution. IR and H-1 NMR studies show that the methacryloyl group associated with the active alkoxy group of the initiator is selectively attached to one chain end. Should the living polymerization be terminated by methacryloyl chloride, and a alpha,omega-dimethacryloyl-PCL, i.e. a alpha,omega-macromonomer is obtained. PCL macromonomers and HEMA are easily copolymerized in the presence of AIBN, resulting in a hydrophilic poly(HEMA) backbone grafted with hydrophobic PCL subchains. [less ▲]

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See detailWR 22 is an Eclipsing Binary Star
Gosset, Eric ULg; Remy, Marc; Manfroid, Jean ULg et al

in Information Bulletin on Variable Stars (1991), 3571

Not Available

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See detailNature of the Variability of VV Scl
Renson, Pierre ULg

in Information Bulletin on Variable Stars (1991), 3568

Not Available

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See detailLong-term photometry of variables at ESO. I - The first data catalogue (1982-1986)
Manfroid, Jean ULg; Sterken, C.; Bruch, A. et al

in Astronomy and Astrophysics. Supplement Series (1991), 87

This paper presents the catalog of photometric data in the Stromgren system obtained during the first four years (October 1982 - September 1986) of the Long-Term Photometry of Variables (LTPV) program at ... [more ▼]

This paper presents the catalog of photometric data in the Stromgren system obtained during the first four years (October 1982 - September 1986) of the Long-Term Photometry of Variables (LTPV) program at ESO. The data are available in computer-readable form. [less ▲]

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See detailThe most massive star of the largest H II region in the Small Magellanic Cloud
Heydari-Malayeri, M.; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1991), 243

It is shown that the brightest star in the most important H II region of the Small Magellanic Cloud (SMC) is a multiple system. The zero-age main sequence mass of this star drops significantly from the ... [more ▼]

It is shown that the brightest star in the most important H II region of the Small Magellanic Cloud (SMC) is a multiple system. The zero-age main sequence mass of this star drops significantly from the previously estimated value of 130 or 110 solar masses to less than 85 solar masses, while its present mass falls from 113 to 58 solar masses, both due to multiplicity and extinction correction. This is another piece of evidence against the existence of stars more massive than about 100 solar masses in the SMC. It is also shown that the present mass of one of the two known O3 stars in the SMC is significantly smaller than presently believed. [less ▲]

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See detailAutomatic Photometry at La Silla
Sterken, C.; Manfroid, Jean ULg

in The Messenger (1991), 63

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See detailAbsence of Laminin Deposition in Breast Cancer and Metastases except to the Brain
Castronovo, Vincenzo ULg; Bracke, M. E.; Mareel, M. M. et al

in Pathology - Research & Practice (1991), 187(2-3), 201-8

Laminin, a major glycoprotein of basement membrane has been found to play significant roles during invasion and metastases. In this study, we have examined the distribution of laminin in several human ... [more ▼]

Laminin, a major glycoprotein of basement membrane has been found to play significant roles during invasion and metastases. In this study, we have examined the distribution of laminin in several human brain carcinoma metastases, human breast cancers, skin and lymph node metastases of breast cancer as well as in an in vitro and an in vivo model of invasion. A laminin accumulation was demonstrated a) at the border between human metastatic carcinoma cells and surrounding neural tissue; b) at the invasive edge between MO4 cells (a highly malignant cell line which synthesizes large amounts of laminin) and host tissues of syngenic mice; c) at the front of invasion between MO4 cells and precultured heart fragments in an in vitro model of invasion. Laminin, but not type IV collagen, promoted attachment of MO4 cells. This attachment was inhibited by preincubation of laminin matrix support with (+)-catechin, a flavonoid which also prevented invasion of the precultured heart fragment in vitro. Our data demonstrate that laminin accumulates between malignant cells and host tissue in human brain metastases and in an in vitro and an in vivo model of invasion. In these later models, accumulation of laminin is the consequence, at least in part, of its biosynthesis by MO4 cells. Since laminin promotes attachment of malignant cells in vitro, increases invasiveness and metastatic activities of murine malignant cells, it is tempting to speculate that laminin synthesized by invasive cells and accumulated at the front of invasion plays a significant role in the first step of invasion. [less ▲]

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See detailRecherche fondamentale et médecine
Ghuysen, Jean-Marie ULg

in Revue Médicale de Liège (1991), 46(3), 115-122

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See detailCytotoxic and mitogenic activities in culture media conditioned by mouse B16 melanoma cells and 3T3 fibroblasts
Siwek, Brigitte; Wauthy, Jacques ULg; Coucke, Paul et al

in Anticancer Research (1991), 11(2), 755-759

Cytotoxic (M.W.< 1000) and mitogenic (M.W.>10000) soluble factors are released into media conditioned by pure or mixed populations of mouse 3T3 fibroblasts and B16 melanoma cells cutivated in vitro. They ... [more ▼]

Cytotoxic (M.W.< 1000) and mitogenic (M.W.>10000) soluble factors are released into media conditioned by pure or mixed populations of mouse 3T3 fibroblasts and B16 melanoma cells cutivated in vitro. They are generally more active on B16 than on fibroblasts. [less ▲]

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See detailNeuroanatomical Specificity in the Co-Localization of Aromatase and Estrogen Receptors
Balthazart, Jacques ULg; Foidart, Agnès ULg; Surlemont, C. et al

in Journal of Neurobiology (1991), 22(2), 143-57

The relative distributions of aromatase and of estrogen receptors were studied in the brain of the Japanese quail by a double-label immunocytochemical technique. Aromatase immunoreactive cells (ARO-ir ... [more ▼]

The relative distributions of aromatase and of estrogen receptors were studied in the brain of the Japanese quail by a double-label immunocytochemical technique. Aromatase immunoreactive cells (ARO-ir) were found in the medial preoptic nucleus, in the septal region, and in a large cell cluster extending from the dorso-lateral aspect of the ventromedial nucleus of the hypothalamus to the tuber at the level of the nucleus inferioris hypothalami. Immunoreactive estrogen receptors (ER) were also found in each of these brain areas but their distribution was much broader and included larger parts of the preoptic, septal, and tuberal regions. In the ventromedial and tuberal hypothalamus, the majority of the ARO-ir cells (over 75%) also contained immunoreactive ER. By contrast, very few of the ARO-ir cells were double-labeled in the preoptic area and in the septum. More than 80% of the aromatase-containing cells contained no ER in these regions. This suggests that the estrogens, which are formed centrally by aromatization of testosterone, might not exert their biological effects through binding with the classical nuclear ER. The fact that significant amounts of aromatase activity are found in synaptosomes purified by differential centrifugation and that aromatase immunoreactivity is observed at the electron microscope level in synaptic boutons suggests that aromatase might produce estrogens that act at the synaptic level as neurohormones or neuromodulators. [less ▲]

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See detailCytological effects of culture media conditioned B16 melanoma cells and 3T3 fibroblasts
Coucke, Paul; Siwek, B.; Gillet, Marie-Claire ULg et al

in Anticancer Research (1991), 11(2), 801-804

Cytotoxic soluble fractions (M.W.<1,000) were prepared from media conditioned by mixed cultures of 3T3 fibroblasts and B16 cells. The ultrastructural analyses of cells (B16 or 3T3) treated with these ... [more ▼]

Cytotoxic soluble fractions (M.W.<1,000) were prepared from media conditioned by mixed cultures of 3T3 fibroblasts and B16 cells. The ultrastructural analyses of cells (B16 or 3T3) treated with these fractions revealed in them mitochondria swelling, blebs, broken membranes and dead cells. [less ▲]

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See detailAntigenic and Genomic Identity between Simian Herpesvirus Aotus Type 2 and Bovine Herpesvirus Type 4
Bublot, M.; Dubuisson, J.; Van Bressem, M. F. et al

in Journal of General Virology (The) (1991), 72((Pt 3)), 715-9

Herpesvirus aotus type 2 (HVA-2) was isolated from a culture of kidney cells from a healthy owl monkey (Aotus trivirgatus). Bovine herpesvirus type 4 (BHV-4) is frequently isolated from diseased and even ... [more ▼]

Herpesvirus aotus type 2 (HVA-2) was isolated from a culture of kidney cells from a healthy owl monkey (Aotus trivirgatus). Bovine herpesvirus type 4 (BHV-4) is frequently isolated from diseased and even healthy cattle and occasionally from sheep, wild ruminants and cats. The two viruses are related antigenically, as was revealed by an indirect fluorescent antibody test using polyclonal antisera from experimentally infected rabbits or monoclonal antibodies raised against six BHV-4 proteins, three of which were glycosylated. The genome structures of the two viruses consist of a unique central sequence flanked at both ends by G + C-rich tandem repeats. Restriction maps (produced using EcoRI, BamHI and HindIII) of these two viruses were nearly identical but the unique sequence of the HVA-2 genome possessed two additional BamHI sites. Four genomic regions of variable size were detected, two located in the unique part, one in the repetitive part and one in the left junction between the unique and the repeated part of the genome; these slight variations were similar to those observed between various BHV-4 isolates. These results suggest that HVA-2 and BHV-4 belong to the same virus species; HVA-2 could be either a BHV-4 contaminant of owl monkey kidney cell cultures or an isolate from an owl monkey accidentally infected with BHV-4. [less ▲]

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See detailLe système immunitaire cutané et le photovieillissement
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1991), 46(3), 158-163

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe ... [more ▼]

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe immunocompétent. Le vieillissement cutané et l'exposition à la lumière ultraviolette ont une influence importante sur le système immunitaire cutané. Après une brève actualisation et description des cellules immunocompétentes de l'épiderme et du derme, nous considérerons la modulation du système immunitaire cutané liée au photovieillissement. [less ▲]

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See detailProjets d'emploi et lieux d'apprentissage privilégiés d'étudiants en fin de scolarité secondaire
Robert, Jocelyne ULg

in Recherche en Education. Théorie & Pratique (1991), 4

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See detailEnhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea resistance by gy gamma-irradiation or drug pretreatment in rat hepatoma cells
Habraken, Yvette ULg; Laval, Françoise

in Cancer Research (1991), 51(4), 499-503

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See detailNucleotide Sequence of the Lipase Gene Lip3 from the Antarctic Psychotroph Moraxella Ta144
Feller, Georges ULg; Thiry, M.; Gerday, Charles ULg

in Biochimica et Biophysica Acta (1991), 1088(2), 323-4

A lipase gene (lip3) from the psychotrophic strain Moraxella TA144 has been cloned and sequenced. The deduced primary structure of the lipase preprotein is composed of 315 amino acids with a predicted Mr ... [more ▼]

A lipase gene (lip3) from the psychotrophic strain Moraxella TA144 has been cloned and sequenced. The deduced primary structure of the lipase preprotein is composed of 315 amino acids with a predicted Mr of 34,772. This enzyme contains two consensus peptides showing cluster of glycine residues that may be involved in domain flexibility. The cloned gene product conserves the low temperature activity and the thermolability properties of the wild enzyme. [less ▲]

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See detailRagged N-Termini and Other Variants of Class a Beta-Lactamases Analysed by Chromatofocusing
Matagne, André ULg; Joris, Bernard ULg; Van Beeumen, J. et al

in Biochemical Journal (1991), 273(273), 503-10

Four beta-lactamases excreted by Gram-positive bacteria exhibited microheterogeneity when analysed by chromatofocusing or ion-exchange chromatography. Ragged N-termini were in part responsible for the ... [more ▼]

Four beta-lactamases excreted by Gram-positive bacteria exhibited microheterogeneity when analysed by chromatofocusing or ion-exchange chromatography. Ragged N-termini were in part responsible for the charge variants, but deamidation of an asparagine residue was also involved, at least for the Bacillus licheniformis enzyme. The activity of a contaminating proteinase could also be demonstrated in the case of Actinomadura R39 beta-lactamase. With that enzyme, proteolysis resulted in partial inactivation, but the inactivated fragments were easily separated from the active forms. With these, as with the other enzymes, the kinetic parameters of the major variants were identical with those of the mixture within the limits of experimental error, so that the catalytic properties of these enzymes can be determined with the 'heterogeneous' preparations. [less ▲]

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See detailThyrotropin-Secreting Pituitary Adenomas: Report of Seven Cases
Beckers, Albert ULg; Abs, R.; Mahler, C. et al

in Journal of Clinical Endocrinology and Metabolism (1991), 72(2), 477-83

Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied ... [more ▼]

Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied between 1.1-36.3 mU/L. The serum alpha-subunit level was low in 1 case, while in 4 other cases the concentration was elevated and varied between 3.7-7.8 micrograms/L. Serum TSH beta levels were normal in the 4 cases in which it was determined. Serum GH or PRL levels were elevated in 5 cases. In 1 patient the cosecretion of TSH, GH, and PRL was confirmed by immunocytochemical examination. Serum TSH and alpha-subunit responses to TRH, GnRH, CRF, GRF, dexamethasone, methimazole, T3, and bromocriptine administration were variable when studied. Serum TSH and alpha-subunit circadian rhythms were absent in 1 case and inverted in another. A serum alpha-subunit pulsatility without TSH pulses was observed in 1 patient. Five patients underwent transsphenoidal adenomectomy. Three of 4 patients operated on in our center were cured, but a recurrence of the adenoma was found in 1 of them after 5 yr. The fifth patient was not cured. Treatment with octreotide in 3 patients resulted in normalization of serum TSH, GH, and thyroid hormones levels. Cosecretion of PRL in 1 case and alpha-subunit in 2 cases was also inhibited. Partial tachyphylaxis occurred in 1 patient. In summary, heterogeneity in clinical presentation, hormonal expression, and therapeutic response appears to characterize these TSH-secreting adenomas. [less ▲]

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See detailPrenatal Diagnosis of Cystic Hygroma and Chorioangioma in the Wolf-Hirschhorn Syndrome
Verloes, Alain ULg; Schaaps, Jean-Pierre ULg; Herens, Christian ULg et al

in Prenatal Diagnosis (1991), 11(2), 129-32

We report the prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in a 24-week-old fetus. Echographic features included cystic hygroma, a complex heart defect with right ventricular hypoplasia, and a ... [more ▼]

We report the prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in a 24-week-old fetus. Echographic features included cystic hygroma, a complex heart defect with right ventricular hypoplasia, and a large placental chorioangioma. We suggest that chorioangioma may be associated with chromosomal imbalance and that systematic careful morphologic examination of the fetus and karyotyping of any pregnancy in which large chorioangioma is detected is advisable. Jugular lymphatic obstruction sequence has not been reported so far in association with 4p-syndrome. [less ▲]

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See detailComparative Morphometric Study of Eruptive Puva-Induced and Chronic Sun-Induced Lentigines of the Skin
Nikkels, Arjen ULg; Ben Mosbah, T.; Pierard-Franchimont, Claudine ULg et al

in Analytical and Quantitative Cytology and Histology (1991), 13(1), 23-26

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by ... [more ▼]

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by solar exposure (actinic lentigines). For these conditions, which appear to be distinctive clinically and histologically, the number, size and shape of the macules were analyzed, revealing significant differences in the two latter parameters. This indicates that UV irradiations of different wave lengths act differently on melanocytes and/or on the interrelation between melanocytes and keratinocytes. The overall effect is much more self-limited in PUVA lentigines than in actinic lentigines, suggesting that the pathophysiology of these lesions is probably different. [less ▲]

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See detailMédicaments anti-asthmatiques. De la pharmacologie à la clinique
Louis, Renaud ULg; Radermecker, Maurice ULg

in Revue Médicale de Liège (1991), 46(2), 58-81

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See detailL'adénome prostatique et son traitement en 1990
Bonnet, Pierre ULg; De Leval, Jean ULg

in Revue Médicale de Liège (1991), 46(2), 45-57

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See detailAnalyse qualitative de la modification de comportements d’enseignement par la technique de la ligne de base multiple
Cloes, Marc ULg; Piéron, Maurice ULg

in STAPS : Revue Internationale des Sciences du Sport et de l'Education Physique (1991), 24

Multiple baseline technique has been frequently related to success in teacher training. In this study, it was applied to change three enthusiastic behaviors by a pre-service teacher (hustles, dynamism ... [more ▼]

Multiple baseline technique has been frequently related to success in teacher training. In this study, it was applied to change three enthusiastic behaviors by a pre-service teacher (hustles, dynamism, feedback). The experimental design was planned for 20 weeks. It comprised 28 lessons and was divided into several phases (baseline, treatment, maintenance, follow up). The experimental design was successful as well in target behavior modification as in short - and long-terme stability of the changes. Qualitative analysis of the results provided useful information about the evolution of target behaviors. The procedure pointed out: (1) the specificity of the evolution of the behavioral changes; (2) the influence of various factors on the short term stability of the behavioral changes; (3) the influence of the duration of the treatment on the long term stability of the behavioral changes, and (4) the positive effects of a timely recall intervention. Data confirmed the reinforcing effect of a systematic follow up in teacher prepatation. [less ▲]

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See detailQuantitative M-Mode and Two-Dimensional Echocardiography in Calves
Amory, Hélène ULg; Jakovljevic, S.; Lekeux, Pierre ULg

in Veterinary Record : Journal of the British Veterinary Association (1991), 128(2), 25-31

A standardised echocardiographic protocol was applied to 18 healthy calves for the estimation of 51 anatomical and functional cardiac variables. These variables were measured in a long axis and a short ... [more ▼]

A standardised echocardiographic protocol was applied to 18 healthy calves for the estimation of 51 anatomical and functional cardiac variables. These variables were measured in a long axis and a short axis view of the heart, and both two-dimensional and cursor-directed time-motion (M-) modes were used. The repeatability of each of the measurements was estimated by comparing values obtained twice within 24 hours, and most of the 51 variables showed a high degree of repeatability. Statistical analysis revealed a close correlation between cardiac measurements taken post mortem and by in vivo echocardiography, and between the echocardiographic values obtained in different scanning planes of the heart or ultrasonic modes, indicating that quantitative echocardiography is a reliable technique in calves. [less ▲]

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