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See detailImpact des tiques sur la croissance des agneaux Djallonké
Hounzangbe, M. S.; Koutinhouin, G. B.; Linton, E. et al

in Annales de Médecine Vétérinaire (2001), 145

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See detailAlpha-2-adrenoreceptors in depressed suicide attempters : relationship with medical lethality of the attempt
Pitchot, William ULg; Hansenne, Michel ULg; Pinto, Emmanuel ULg et al

in Neuropsychobiology (2001), 44(2), 91-94

Several lines of evidence tend to suggest a role for noradrenaline, and more specifically alpha-2-adrenoreceptors, in the biology of suicidal behavior. The purpose of this study was to assess the growth ... [more ▼]

Several lines of evidence tend to suggest a role for noradrenaline, and more specifically alpha-2-adrenoreceptors, in the biology of suicidal behavior. The purpose of this study was to assess the growth hormone (GH) response to clonidine, an alpha-2-adrenergic agonist, in majorly depressed inpatients with a history of highly lethal suicide attempt compared to depressed patients with a history of low lethal suicide attempt and nonattempters. Our sample included 20 male depressed inpatients with a history of suicide attempt compared to 20 male depressed nonattempters. We did not observe any significant difference between suicide attempters and nonattempters for GH peak values (2.4 +/- 2.9 vs. 4.1 +/- 3.7 ng/ml; F = 2.52, d.f. = 1, 38, p = 0.12). Moreover, GH peak responses to clonidine were not related to the degree of lethality of the attempt. The results of the present study do not support a major role for noradrenaline in the biology of suicidal behavior. [less ▲]

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See detailNeuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro
Calaora, Viviane; Rogister, Bernard ULg; Bismuth, Karen et al

in Journal of Neuroscience (2001), 21

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See detailChanges in lipoxygenase and hydroperoxide decomposition activity in tissues cultures of soybean
Fauconnier, Marie-Laure ULg; Mouttalib, A.; Billo, D. et al

in Journal of Plant Physiology (2001), 158(7), 953-955

Glycine max L. tissue cultures were initiated on different media supplemented with appropriate plant growth regulators that specifically induce the formation of callus, root, or shoot primordia ... [more ▼]

Glycine max L. tissue cultures were initiated on different media supplemented with appropriate plant growth regulators that specifically induce the formation of callus, root, or shoot primordia. Exogenously applied hormones resulted in important changes in both Lox and HPO decomposition activity. Lox activity was higher in extracts from tissues cultured in medium supplemented with NAA or 2,4-D, while a lowest activity was recorded in extracts from cultures treated with BA. 13-HPOD was cleaved by all tested extracts, while 13-HPOT and 9-HPOD were cleaved exclusively by extracts from tissues cultured in the presence of BA. [less ▲]

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See detailTreatment of recurrent tendinitis by isokinetic eccentric exercises
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Foidart-Dessalle, Marguerite ULg et al

in Isokinetics & Exercise Science (2001), 9(2-3), 133-141

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities ... [more ▼]

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities, Isokinetic eccentric training was administered to 34 patients with chronic tendinitis (9 Achilles, 10 patellar and 15 epicondyllar) with a long duration of symptoms and failure of conventional treatment. Following training which consisted of 20 to 30 sessions of progressive increase of load and speed parameters, a significant reduction of pain indicated by the visual analog scale (average initial value > 6.5, final score less than or equal to 2.5). Seventy four percent of the patients were completely relieved or presented marked decrease in symptoms when returning to sport and occupational activities. and only 12% reported no change in their functional state. At the end of treatment. isokinetic assessment revealed no significant concentric or eccentric peak torque asymmetries between involved and non-involved sides. In comparison with pretreatment ultrasound observations which showed systematic hypoechoic lesions and thickness, 14/34 patients recovered homogeneous tendon structure and normalization of the diameter and 15 presented improvement in echostructure. Our treatment model proposing isokinetic eccentric exercises presents a very satisfactory short-term effect on three different localizations of chronic tendinitis. [less ▲]

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See detailAtomic transition probabilities in Bi II
Palmeri, P.; Quinet, Pascal ULg; Biémont, Emile ULg

in Physica Scripta (2001), 63

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See detailKey criteria for the design of polymeric stabilizers for aqueous titanium dioxide dispersions of high solid content
Creutz, Serge; Jérôme, Robert ULg

in e-Polymers (2001), (14), 1-9

Amphiphilic copolymers consisting of an animated hydrophobic block and a hydrophilic poly(sodium methacrylate) one have been synthesized with different structures and tested as stabilizers for aqueous ... [more ▼]

Amphiphilic copolymers consisting of an animated hydrophobic block and a hydrophilic poly(sodium methacrylate) one have been synthesized with different structures and tested as stabilizers for aqueous dispersions of alumina coated titanium dioxide (80 wt.-% solid). The dispersion stability is ruled by the strength of the anchoring of the aminated block onto the pigment and by the dynamics of the micelles formed by the copolymer. Any decrease in the anchoring strength, for example as a result of higher steric hindrance for the adsorbing block or of random rather than blocky distribution of the aminated co-units, is detrimental to the dispersion stability and makes this stability more dependent on the copolymer composition. Indeed, the position and dynamics of the unimers micelles equilibrium then control the adsorption of the copolymer on the pigment during the grinding process. [less ▲]

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See detailEvaluations internationales : Les enjeux du jour et de l'histoire
Baye, Ariane ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 11-23

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See detailCoordinated regulation of procollagens I and III and their post-translational enzymes by dissipation of mechanical tension in human dermal fibroblasts.
Lambert, Charles ULg; Colige, Alain ULg; Lapiere, C. M. et al

in European Journal of Cell Biology (2001), 80(7), 479-85

Mechanical tension governs fibroblast proliferation and survival and the homeostasis of the extracellular matrix to adapt its resistance to the mechanical requirements of the organs. To consolidate this ... [more ▼]

Mechanical tension governs fibroblast proliferation and survival and the homeostasis of the extracellular matrix to adapt its resistance to the mechanical requirements of the organs. To consolidate this view, we analysed the effect of tension release on the expression of molecules involved in the architecture and stabilisation of the collagen fibres, namely the procollagens type I and III, the amino- and carboxy-procollagen peptidases (N-pCP and C-pCP) and lysyl oxidase. Cells were cultured in conditions of high mechanical stress in monolayer on a collagen coat and under reduced tension by disruption of the cytoskeleton upon treatment with cytochalasin D in monolayer on a collagen coat or by integrin-mediated stress relaxation in a freely retracting collagen gel. The mRNAs were measured by quantitative RT-PCR monitored by simultaneous reverse-transcription and amplification of an original internal standard. Tension relaxation resulted in a decreased expression of the procollagens type I and III, of the two expressed forms of C-pCP, of the two forms of N-pCP and of lysyl oxidase. Type III collagen, known to control diameter of the fibres, was less down-regulated than type I collagen. Interestingly, the expression of the two alternatively spliced forms of the N-pCP was dissimilarly regulated. These data suggest that mechanical tension may modulate the stiffness of the extracellular matrix by controlling not only the level of expression of its fibrillar constituents but also that of the enzymes participating in their extracellular processing and mechanical stabilisation. [less ▲]

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See detailCrystallization and preliminary X-ray analysis of a bacterial psychrophilic enzyme, phosphoglycerate kinase
Mandelman, D.; Bentahir, M.; Feller, Georges ULg et al

in Acta Crystallographica Section D-Biological Crystallography (2001), 57(Pt 11), 1666-8

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and ... [more ▼]

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and decreased thermostability relative to its mesophilic counterpart. Herein, the preliminary crystallization and structure solution of psychrophilic PGK in its native form and cocrystallized with 3-phosphoglyceric acid (3-PGA) and the ATP analogue adenylyl imidophosphate (AMP-PNP) is reported. The complexed form of PGK crystallized in 2-3 d at 290 K, whereas the native form of the enzyme required 8-12 months. Morphologically, both crystal forms are similar and X-ray diffraction experiments indicate that the crystals are isomorphous. The crystals diffracted to a resolution of 2.0 A and belong to the space group P3(2). with unit-cell parameters a = b = 58.5, c = 85.4 A. [less ▲]

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See detailIleo-caecal actinomycosis: Report of a case simulating complicated inflammatory bowel disease
Postal, Alain; Detry, Olivier ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (2001), 64(4, Oct-Dec), 318-320

Abdominal actinomycosis is a rare infectious disease caused by Actinomyces israelii, a gram-positive anaerobic saprophyte germ that is a normal inhabitant of the upper intestinal tract in humans ... [more ▼]

Abdominal actinomycosis is a rare infectious disease caused by Actinomyces israelii, a gram-positive anaerobic saprophyte germ that is a normal inhabitant of the upper intestinal tract in humans. Actinomyces israelii rarely cause abdominal infections or actinomycosis. Abdominal actinomysosis is characterised by fistulae and abscesses and may mimic cancer or inflammatory bowel disease. Abdominal actinomycosis is difficult to diagnose preoperatively, and often require surgical removal of the diseased tissue, allowing pathologists for giving the definitive diagnosis, revealed by characteristic "sulfur granules". The authors report herein the case of a 47-year-old man who presented with diarrhoea and abdominal pain. Abdominal computed tomography evoked complicated inflammatory bowel disease and surgical procedure was decided. Laparoscopic exploration did not provide further significant information, and laparotomy with diseased bowel resection was performed. Pathology demonstrated "sulfur granules" and allowed the diagnosis of abdominal actinomycosis. This case demonstrated that abdominal actinomycosis should be included in the differential diagnosis when computed tomography shows an infiltrative and inflammatory mass. [less ▲]

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See detailTreatment of drug-induced toxic epidermal necrolysis (Lyell’s syndrome) with intravenous human immunoglobulins
Paquet, Philippe ULg; JACOB, Eric; Damas, Pierre ULg et al

in Burns : Journal of the International Society for Burn Injuries (2001), 27(6), 652-655

Toxic epidermal necrolysis (TEN) is a rare drug-induced life-threatening disease. Currently, the disease is only treated by supportive and antiseptic measures. Quite recently intravenous immunoglobulins ... [more ▼]

Toxic epidermal necrolysis (TEN) is a rare drug-induced life-threatening disease. Currently, the disease is only treated by supportive and antiseptic measures. Quite recently intravenous immunoglobulins (IG) were shown to be a promising TEN treatment. The rationale for their use is based on the fact that keratinocyte apoptosis in TEN involves the CD95 (APO-1/Fas) cell surface receptor–ligand system. We successfully treated a TEN patient with high dose of intravenous IG. The clinical recovery appeared exceptionally rapid. Immunohistochemistry showed that the IG action probably developed on the CD95 receptor–ligand system at the keratinocytes surface. [less ▲]

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See detailMaxbias curves of robust scale estimators based on subranges
Croux, C.; Haesbroeck, Gentiane ULg

in Metrika (2001), 53(2), 101-122

A maxbias curve is a powerful tool to describe the robustness of an estimator. It is an asymptotic concept which tells how much an estimator can change due to a given fraction of contamination. In this ... [more ▼]

A maxbias curve is a powerful tool to describe the robustness of an estimator. It is an asymptotic concept which tells how much an estimator can change due to a given fraction of contamination. In this paper, maxbias curves are computed for some univariate scale estimators based on subranges: trimmed standard deviations, interquantile ranges and the univariate Minimum Volume Ellipsoid (MVE) and Minimum Covariance Determinant (MCD) scale estimators. These estimators are intuitively appealing and easy to calculate. Since the bias behavior of scale estimators may differ depending on the type of contamination (outliers or inliers), expressions for both explosion and implosion maxbias curves are given. On the basis of robustness and efficiency arguments, the MCD scale estimator with 25% breakdown point can be recommended for practical use. [less ▲]

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See detailQuelle évaluation externe des élèves pour quels socles de compétences ?
Bodin, A.; Delory, C.; Lafontaine, Dominique ULg et al

in Pédagogies, réformes et innovations dans l'enseignement (2001), 14

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See detailUtilisation des gènes à effet majeur en sélection laitière. Un exemple: le gène Pit-1
Renaville, Robert ULg; Parmentier, Isabelle; Fontaine, Sandrine et al

in Les Elevages belges (2001), 4

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See detailBulletin bibliographique de la Société Rencesvals 2000-2001
Henrard, Nadine ULg

in Bulletin Bibliographique de la Société Rencesvals pour l'étude des épopées romanes (2001), (32), 1-237

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See detailDynamique de modification de l'habitat physique de reproduction des pondeurs lithophiles sous gravier. Cas de deux frayères à ombre dans l'Aisne
Parkinson, Denis; Petit, François ULg; Houbrechts, Geoffrey ULg et al

in Bulletin de la Société Géographique de Liège (2001), 40

D’octobre 1998 à mars 1999, nous avons étudié dans l’Aisne, petit affluent ardennais de l’Ourthe, la dynamique de modification de deux bancs de gravier utilisés comme frayère par l’ombre commun en mars ... [more ▼]

D’octobre 1998 à mars 1999, nous avons étudié dans l’Aisne, petit affluent ardennais de l’Ourthe, la dynamique de modification de deux bancs de gravier utilisés comme frayère par l’ombre commun en mars-avril 1998. L’étude a été réalisée dans deux stations du cours inférieur de l’Aisne où se sont succédé quatre crues morphogènes. Dans chaque station, nous avons déterminé à intervalle d’environ 1 mois, la profondeur d’érosion et la hauteur de dépôt des sédiments (méthode de la barre d’érosion à chaînes), la granulométrie des matériaux des couches de surface et de subsurface, le dépôt des sédiments fins (placement de pièges à sédiments) et la perméabilité du substrat (méthode du standpipe). En complément, nous avons entrepris dans une station de l’Aisne moyenne, une caractérisation de divers éléments de la dynamique fluviale : identification des débits mobilisateurs (par marquage colorimétrique des sédiments en place), estimation de la vitesse de déplacement de la charge de fond (par étude de la dispersion longitudinale de scories, résidu d’anciennes industries métallurgiques) et estimation des quantités de sédiments charriés par la rivière (à partir des données de dragage). [less ▲]

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See detailN content of phloem and xylem exudates during the transition to flowering in Sinapis alba and Arabidopsis thaliana
Corbesier, Laurent; Havelange, Andrée ULg; Lejeune, Pierre et al

in Plant, Cell & Environment (2001), 24

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower ... [more ▼]

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower by one long day (LD). In S. alba, the phloem sap (leaf and apical exudates) and the xylem sap (root exudate) were analysed in LD versus SD. In A. thaliana, only the leaf exudate could be analysed but an alternative system for inducing flowering without day-length extension was used: the displaced SD (DSD). Significant results are: (i) in both species, the leaf exudate was enriched in Gln during the inductive LD, at a time compatible with export of the floral stimulus; (ii) in S. alba, the root export of amino acids decreased in LD, whereas the nitrate remained unchanged - thus the extra-Gln found in the leaf exudate should originate from the leaves; (iii) extra-Gln was also found very early in the apical exudate of S. alba in LD, together with more Glu; (iv) in A. thaliana induced by one DSD, the leaf export of Asn increased sharply, instead of Gln in LD. This agrees with Asn prevalence in C-limited plants. The putative role of amino acids in the transition to flowering is discussed. [less ▲]

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See detailPraxéologies didactiques et praxéologies mathématiques, à propos d'un enseignement des limites au secondaire.
Schneider, Marguerite ULg

in Recherches en Didactique des Mathématiques (2001), 21(1-2), 7-50

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See detailEvolution des organisations urbaines et mobilités quotidiennes : espace de référence et analyse des processus
Halleux, Jean-Marie ULg

in Espace Géographique (L') (2001), 30(1), 67-80

Cet article traite des liens entre la mobilité quotidienne et les évolutions intra-urbaines. Dans ce cadre, un espace géographique urbain de référence a tout d'abord été construit ; afin de clarifier des ... [more ▼]

Cet article traite des liens entre la mobilité quotidienne et les évolutions intra-urbaines. Dans ce cadre, un espace géographique urbain de référence a tout d'abord été construit ; afin de clarifier des processus d'évolution, il semble en effet naturel de débuter par la définition d'un état stable. Concernant les processus, plusieurs différenciations ont été opérées, notamment : l'urbanisation par rapport à la désurbanisation et l'urbanisation fonctionnelle par rapport à l'urbanisation morphologique. La problématique des types de mobilité a également été intégrée, ce qui a déterminé une réflexion sur le thème de la transition périurbaine, c'est-à-dire le processus de mutation de la ville sous l'impact de la mobilité automobile. [less ▲]

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See detailInteractions between systemic analgesics.
Joris, Jean ULg; Kaba, Abdourahmane ULg

in Acta Anaesthesiologica Belgica (2001), 52(4), 395-401

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See detailMicro-analyse des mécanismes de la reprise démographique des villages de l'Ardenne du Nord-Est : le cas de Burtonville
Schmitz, Serge ULg

in Espace, Populations, Sociétés (2001)

If they are well selected, macro scale analyses permit to underline some mechanisms that remain hidden or are difficult to distinguish with micro scale analysis. The populations' stories an history of ... [more ▼]

If they are well selected, macro scale analyses permit to underline some mechanisms that remain hidden or are difficult to distinguish with micro scale analysis. The populations' stories an history of Burtonville in their regional context show : - lags of demographic revivals between villages and small towns - relevance of material constraints inherent in a small village for the demographic development - relevance of landed property and genealogy for the village evolution - links between demographic and economic evolutions - diversification of environmental aspirations and their results on migrations. [less ▲]

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See detailExperimental Hafting Traces. Identification and Characteristics
Rots, Veerle ULg; Pirnay, Louis; Pirson, Philippe et al

in Notae Praehistoricae (2001), 21

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See detailUrethral sphincterotomy for delivery of a vesical calculus in the mare: a case report
Deleuze, Stefan ULg; Hanzen, Christian ULg

in Annales de Médecine Vétérinaire (2001), 145(6, Suppl. S), 373-376

A case of a cystic calculus in a mare and the pathophysiology of urolithiasis are described. In this case a 268 g calculus measuring 9 x 6 cm was removed after urethro-sphincterotomy was performed on the ... [more ▼]

A case of a cystic calculus in a mare and the pathophysiology of urolithiasis are described. In this case a 268 g calculus measuring 9 x 6 cm was removed after urethro-sphincterotomy was performed on the standing mare. [less ▲]

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See detailComparison by image processing of target supports of spray droplets
Degre, Aurore ULg; Mostade, Olivier; Huyghebaert, Bruno et al

in transaction of the American society of Agricultural engineers (2001), 44(2), 217-222

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See detailEffect of Intravenous Platelet-Activating Factor on Bovine Pulmonary Mast Cells
Jolly, Sandra ULg; Thomas, Cédric; Genicot, Bruno et al

in Journal of Comparative Pathology (2001), 125(Aug-Oct), 81-89

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six ... [more ▼]

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six animals, which were killed approximately 10 min later. No macroscopical lesions were observed in the lung tissue of five control calves. On semi-thin toluidine-blue stained sections, MC cytoplasm showed profuse deep-blue granulation. In the lung tissues of PAF-treated calves, striking interstitial, alveolar and interlobular oedema and emphysema were observed. MC granules occurred at the periphery of the cytoplasm and MC nuclei were easily detectable. Moreover, the number of granules in the MC cytoplasm was remarkably low. A few granules with some metachromatic material were sometimes detected outside the cell limits. Ultrastructurally, the matrix pattern of the MC granules in lung tissues of control calves was either amorphous or granular. In lung tissues of the PAF-treated calves, the granular matrix pattern was pronounced, varying from fine- to coarse-grained, and the MCs were of reduced size, with many filiform processes and exocytotic vesicles. These findings indicate that pulmonary MC degranulation was induced by PAF in healthy calves. [less ▲]

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See detailNotes sur la présence d'Indra dans le panthéon ârya
Swennen, Philippe ULg

in Studi Epigrafici e Linguistici sul Vicino Oriente Antico (2001), 18

The indo-iranian use of the compound adjective skt. haryaçva op. zariasba suggests that the god Indra was already known in the common ârya pantheon.

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See detailBELL, regular 2001 issue
Delrez, Marc ULg

in Belgian Essays on Language and Literature (2001)

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See detailUnimolecular reaction dynamics from kinetic energy release distributions. 8. Protonated fluorobenzene and structure of the phenyl ion
Lorquet, Jean-Claude ULg; Lorquet, Andrée

in Journal of Physical Chemistry A (2001), 105(15), 3719-3724

A previous interpretation of the kinetic energy release distribution (KERD) observed in the fragmentation of protonated fluorobenzene is confirmed by a maximum entropy analysis. The KERD is bimodal, with ... [more ▼]

A previous interpretation of the kinetic energy release distribution (KERD) observed in the fragmentation of protonated fluorobenzene is confirmed by a maximum entropy analysis. The KERD is bimodal, with an intense and broad component due to the production of the cyclic phenyl ion. Ab initio calculations indicate the existence of several open-chain isomers, with an energy about 1.0-1.2 eV higher than that of the phenyl ring. A weaker component of the KERD corresponds to the formation of one or several of these acyclic structures. Its abundance represents about 6% of the main component (but drops down to 3% for the perdeuterated isomer). More translational energy than the statistical estimate is released during the dissociation process because of the presence of a barrier along the reaction path leading to the generation of the cyclic phenyl ion. About one-half of the energy of the barrier is released as translation, thereby indicating the operation of strong exit-channel interactions between separating fragments. © 2001 American Chemical Society. [less ▲]

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See detailInfections virales humaines d'origine alimentaire
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Point Vétérinaire (2001), 218

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See detailNews on antifungal drugs registered in Belgium for the treatment of dermatophytosis in domestic carnivores.
Hamoir, J.; Goret, M.; Mignon, Bernard ULg et al

in Annales de Médecine Vétérinaire (2001), 145

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the ... [more ▼]

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the therapeutic protocols used in this type of diseases but rather to describe these compounds according to their pharmacological and toxicological characteristics as well as to define their status in the current legal framework. [less ▲]

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See detailTransduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation.
Minet, E.; Michel, G.; Mottet, Denis ULg et al

in Free Radical Biology & Medicine (2001), 31(7), 847-55

Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers ... [more ▼]

Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers the overexpression of genes coding for glycolytic enzymes and angiogenic factors. To be active HIF-1 must be phosphorylated. HIF-1 is a substrate for various kinase pathways including PI-3K and the MAP kinases ERK and p38. Several transduction pathways have been proposed which act downstream of putative oxygen sensors and lead to the activation of these kinases. In this review, we summarize some of the latest advances describing the possible signaling pathways leading to HIF-1 phosphorylation and subsequent activation. The physiological relevance of these regulations is also discussed. [less ▲]

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See detailEmissions gazeuses en élevage porcin et modes de réduction : revue bibliographique
Degre, Aurore ULg; Verheve, Didier; Debouche, Charles ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(3), 135-143

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See detailProductivity Overshadows Temperature In Determining Soil And Ecosystem Respiration Across European Forests
Janssens, Ia.; Lankreijer, H.; Matteucci, G. et al

in Global Change Biology (2001), 7(3),

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See detailQuantitative cell dispersion analysis: new test to measure tumor cell aggressiveness
Nawrocki-Raby, Béatrice; Polette, Myriam; Gilles, Christine ULg et al

in International Journal of Cancer = Journal International du Cancer (2001), 93(5), 644-52

Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between ... [more ▼]

Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between cell dispersion and cell invasion, related respectively to expression of E-cadherin/catenin complex and matrix metalloproteinases (MMPs), we developed an original in vitro model of cell dispersion analysis. Our study reports the validation of this model that allowed us to analyze and quantify the cell cohesion level by means of time-lapse videomicroscopy and computer analysis based on the observation of spatial and temporal cell distribution. Our model was able to distinguish 2 groups among different human bronchial and mammary epithelial cells previously characterized for the expression of E-cadherin/catenin complex and MMPs and their invasive capacity in the Boyden chamber assay. The first group (16HBE14o-, MCF-7, T47D) that expressed membranous E-cadherin and -catenin, and was negative for MMP-2 expression and non-invasive, displayed a highly cohesive pattern corresponding to a cluster spatial distribution. The second group (Beas2B, BZR, BZR-T33, MDA-MB-231, MDA-MB-435, BT549 and HS578T) that was invasive and showed lack of expression of E-cadherin and a cytoplasmic redistribution of -catenin, displayed a dispersed pattern corresponding to a random spatial distribution. Downregulation of E-cadherin by a blocking antibody induced a more random distribution. Conversely, expression of E-cadherin by cDNA transfection induced a cluster distribution. Moreover, tumor cell lines that co-expressed MT1-MMP and MMP-2 (Beas2B, BZR, BZR-T33, MDA-MB-435, BT549 and HS578T) showed a more dispersed pattern than tumor cell lines that did not express MMP-2 (MDA-MB-231). In conclusion, we demonstrated that the spatial group behavior of cell lines, i.e., their cohesion/dispersion ability, reflects their invasive properties. Thus, this model of cell dispersion analysis may represent a new test to measure tumor cell aggressiveness. [less ▲]

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See detailFactors inftuencing ribavirin-induced hemolysis
Van Vlierberghe, H.; Delanghe, J. R.; De Vos, M. et al

in Journal of Hepatology (2001), 34

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study ... [more ▼]

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study tried to search for these variables in a large group of patients with hepatitis C treated with the combination therapy. Methods: Two hundred and forty-four patients chronically infected with the hepatitis C virus were treated either with induction treatment (daily dose ofinterferon) or with a standard treatment (interferon thrice weekly). Both groups received 1000-1200 mg of ribavirin from week 4 until the end of the treatment. The drop in hemoglobin level was defined as the dift'erence between the pretreatment hemoglobin level and the hemoglobin level at week 8. Seventeen variables which could possibly influencê'this drop in hemoglobin level were examined. Results: After multivariate analysis, the drop in hemoglobin level was only significant influenced by pretreatment platelet level, treatment and haptoglobin phenotype. The ribavirin dose did not influence the drop in hemoglobin level or the early virological response. Conclusions: Ribavirin-induced hemolysis is inftuenced by the pretreatment platelet level, the administered amount of a-interferon and the haptoglobin phenotype. A careful search for the minimal dose of ribavirin needed in combination treatment is necessary. [less ▲]

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See detailLa réception de l’art japonais en Belgique
Bawin, Julie ULg

in Art&Fact (2001)

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See detail3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detailGiacomo Leopardi e Francesco Guicciardini
Moreno, Paola ULg

in Studi e Problemi di Critica Testuale (2001), LXII

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See detailCarbon balance gradient in European forests: should we doubt 'surprising' results? A reply to Piovesan & Adams
Jarvis, P. G.; Dolman, A. J.; Schulze, E. D. et al

in Journal of Vegetation Science (2001), 12(1), 145-150

This paper responds to the Forum contribution by Piovesan & Adams (2000) who criticized the results obtained by the EUROFLUX network on carbon fluxes of several European forests. The major point of ... [more ▼]

This paper responds to the Forum contribution by Piovesan & Adams (2000) who criticized the results obtained by the EUROFLUX network on carbon fluxes of several European forests. The major point of criticism was that the data provided by EUROFLUX are inconsistent with current scientific understanding. It is argued that understanding the terrestrial global carbon cycle requires more than simply restating what was known previously, and that Piovesan & Adams have not been able to show any major conflicts between our findings and ecosystem or atmospheric-transport theories. [less ▲]

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See detailPIT-1, a candidate gene for mass assisted selection in dairy bulls.
Parmentier, Isabelle; Gengler, Nicolas ULg; Fontaine, S. et al

in Journal of Animal Science (2001), 79(Suppl 1, N°1412), 340

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See detailRevising the judicial architecture of the European Union
Munoz, Rodolphe ULg

in Yearbook of European law (2001), 19

L'article reprend l'ensemble des propositions faites à l'époque par la doctrine concernant les modifications à apporter à l'architecture juridique de l'Union. Chacun des articles du contentieux est ... [more ▼]

L'article reprend l'ensemble des propositions faites à l'époque par la doctrine concernant les modifications à apporter à l'architecture juridique de l'Union. Chacun des articles du contentieux est analysée et des propositions concrètes de mofdifications sont faites. [less ▲]

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See detailEstimation of genetic covariances with Method R
Druet, Tom ULg; Misztal, I.; Duangjinda, M. et al

in Journal of Animal Science (2001), 79(3), 605-615

Method R is a simple and computationally inexpensive method for estimating (co)variances. The objective of the study was to investigate properties of Method R for estimation of (co)variance components ... [more ▼]

Method R is a simple and computationally inexpensive method for estimating (co)variances. The objective of the study was to investigate properties of Method R for estimation of (co)variance components with emphasis on covariance estimation. Theoretical Method R formulas were developed for simplified single-variate and bivariate models. In single-trait models, the curve of the regression of Method R was continuous and monotonic and its slope depended on the amount of information on each animal and on the variance ratio. The curve became steeper as the number of records per animal decreased. For covariance, the curve of the regression was monotonic but not continuous. However, a regression coefficient of 1 still corresponded to the correct covariance. Similar curves were observed in analyses of simulated data sets. Because of the observed discontinuity, algorithms implementing Method R that require a continuous regression curve would not work in models with: covariances. An alternative algorithm was based on a transformation matrix obtained by multiplying a matrix of numerators with the inverse of a matrix of denominators of the regression factors. Such an algorithm converged reliably for all models tested. Method R can be modified to estimate covariances in models too large for other methods. [less ▲]

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See detailMolecular certification in chicken meat channel.
Haezebroeck, Valérie; Renaville, Robert ULg; Parmentier, Isabelle et al

in Journal of Animal Science (2001), 79(Suppl 1 N°1072), 260

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See detailPropofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography study.
Bonhomme, Vincent ULg; Fiset, P.; Meuret, P. et al

in Journal of Neurophysiology (2001), 85(3), 1299-308

We investigated the effects of the general anesthetic agent propofol on cerebral structures involved in the processing of vibrotactile information. Using positron emission tomography (PET) and the H(2)(15 ... [more ▼]

We investigated the effects of the general anesthetic agent propofol on cerebral structures involved in the processing of vibrotactile information. Using positron emission tomography (PET) and the H(2)(15)O bolus technique, we measured regional distribution of cerebral blood flow (CBF) in eight healthy human volunteers. They were scanned under five different levels of propofol anesthesia. Using a computer-controlled infusion, the following plasma levels of propofol were targeted: Level W (Waking, 0 microg/ml), Level 1 (0.5 microg/ml), Level 2 (1.5 microg/ml), Level 3 (3.5 microg/ml), and Level R (Recovery). At each level of anesthesia, two 3-min scans were acquired with vibrotactile stimulation of the right forearm either on or off. The level of consciousness was evaluated before each scan by the response of the subject to a verbal command. At Level W, all volunteers were fully awake. They reported being slightly drowsy at Level 1, they had a slurred speech and slow response at Level 2, and they were not responding at all at Level 3. The following variations in regional CBF (rCBF) were observed. During the waking state (Level W), vibrotactile stimulation induced a significant rCBF increase in the left thalamus and in several cortical regions, including the left primary somatosensory cortex and the left and right secondary somatosensory cortex. During anesthesia, propofol reduced in a dose-dependent manner rCBF in the thalamus as well as in a number of visual, parietal, and prefrontal cortical regions. At Level 1 through 3, propofol also suppressed vibration-induced increases in rCBF in the primary and secondary somatosensory cortex, whereas the thalamic rCBF response was abolished only at Level 3, when volunteers lost consciousness. We conclude that propofol interferes with the processing of vibrotactile information first at the level of the cortex before attenuating its transfer through the thalamus. [less ▲]

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See detailPrognostic value of decremental responses to repetitive nerve stimulation in ALS patients.
Wang, François-Charles ULg; De Pasqua, Victor ULg; Gerard, Pascale ULg et al

in Neurology (2001), 57(5), 897-9

Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP ... [more ▼]

Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP size as well as motor unit number and size estimates were evaluated twice before and after 1 year of riluzole therapy. The correlation between decrement and CMAP size reduction per year was highly significant (r = 0.77), but no relationship could be demonstrated between decrement and other variables. The authors thus propose that decrement after RNS may be used as a predictor of further drop in CMAP size. [less ▲]

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See detailTibère, les cultes étrangers et les astrologues (Suétone, Vie de Tibère, 36)
Rochette, Bruno ULg

in Etudes Classiques (Namur, Belgium) (2001), 69

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See detailDevelopment of specific antibodies for the quantificaion of plasma insulin-like growth factor-binding protein-3 in cattle.
Renaville, Robert ULg; Bertozzi, C.; Hetzel, S. et al

in Journal of Animal Science (2001), 79(suppl 1, N°1610), 388

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See detailUne révision critique de la distribution de Tortula inermis en Belgique
Vanderpoorten, Alain ULg; Stieperaere, H.; Sotiaux, André ULg

in Dumortiera (2001), 77

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See detailAPRIL IN CHICAGO
Sacré, Robert ULg

in Soul Bag (2001), (163), 50

The Center for Black Music Research sur le web . Scènes du blues et du gospel

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See detailOptimisation of Stiffened Structures
Rigo, Philippe ULg

in Dept. of Naval Architecture and Marine Engineering (2001)

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See detailSperm size and number variation in the red flour beetle
Arnaud, Ludovic; Haubruge, Eric ULg; Gage, Matthew

in Zoological Journal of the Linnean Society (2001), 133

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See detailSynthesis and optical properties of opal and inverse opal photonic crystals
Johnson, N. P.; McComb, D. W.; Richel, Aurore ULg et al

in Synthetic Metals (2001), 116(1-3), 469-473

We describe the synthesis of two complementary photonic crystals: opal and an inverted opal structure consisting of air spheres in a titania matrix. From optical measurements and comparison with the ... [more ▼]

We describe the synthesis of two complementary photonic crystals: opal and an inverted opal structure consisting of air spheres in a titania matrix. From optical measurements and comparison with the literature, the mechanical strength and effective refractive index are increased by sintering for opal and because of compression for the inverse opal. However, this is at the expense of reducing the PBG in the [1 1 1] direction. [less ▲]

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See detailSpécificité et histoire des discours sémiotiques
Badir, Sémir ULg; Arrivé, Michel

in Linx (2001), 44

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See detailUn nouveau projet archéologique de l'Université de Lyon 2.
Morard, Thomas ULg; Wavelet, David

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2001), 113(1), 477-481

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See detailRemission of severe cold agglutinin disease after Rituximab therapy.
LAYIOS, Nathalie ULg; Van Den Neste, E.; Jost, E. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2001), 15(1), 187-8

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See detailNumerical modelling of lateral-torsional buckling of steel I-beams under fire conditions - Comparison with Eurocode 3
Vila Real, Paulo M. M.; Franssen, Jean-Marc ULg

in Journal of Fire Protection Engineering (2001), 11(2), 112-128

A geometrically and materially non-linear finite element program, i.e., a general model, has been used to determine the lateral-torsional resistance of steel I-beams under fire conditions, according to ... [more ▼]

A geometrically and materially non-linear finite element program, i.e., a general model, has been used to determine the lateral-torsional resistance of steel I-beams under fire conditions, according to the same material properties of Eurocode 3, Part 1-2. Two yield strengths, one cross section, one type of load and four different time exposures to the ISO 834 standard fire have been considered. The numerical results have been compared to the results of the simple model presented in Eurocode 3, Part 1-2. When compared with the general model, this simple model leads to a safety level that depends on the slenderness of the beam, being unsafe for intermediate non-dimensional slenderness. A new proposal has been made for a simple model that ensures a conservative result when compared to the general model. [less ▲]

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See detailLes devoirs: Un canal de communication entre l'école et les familles
Poncelet, Débora ULg; Schillings, Patricia ULg; Hindryckx, Geneviève ULg et al

in Point sur la Recherche en Education (Le) (2001), 20

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See detailEffet of dietary fat levels on growth, feed efficiency and biochemical compositions of Eurasian perch Perca fluviatilis
Xu; Fontaine, P.; Mélard, Charles ULg et al

in Aquaculture International (2001), 9

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See detailThe role of integrins in human embryo implantation
Merviel, P.; Challier, J. C.; Carbillon, L. et al

in Fetal Diagnosis & Therapy (2001), 16(6), 364-371

Integrins are adhesion molecules present in endometrial, decidual, and extravillous cytotrophoblast (EVCT) cells. They participate in cell-cell adhesion as well as in adhesion between cells and components ... [more ▼]

Integrins are adhesion molecules present in endometrial, decidual, and extravillous cytotrophoblast (EVCT) cells. They participate in cell-cell adhesion as well as in adhesion between cells and components of the extracellular matrix, and they play an important role in the endometrial phenotype change that occurs during the secretory phase, the first stage of implantation. At the beginning of pregnancy, the change in integrin expression is synchronized with the trophoblast attachment (embryo-endometrium interactions with integrins v3, 41, 61, and 71) and the embryo's invasion of the decidua (integrins 64511141 switch from proliferative to endovascular EVCT). Several diseases, including preeclampsia, intrauterine growth retardation caused by vascular problems and defective luteal phases, may be explained by anomalies in integrin patterns. [less ▲]

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See detailChemical Recognition of Antioxidants and UV-light Stabilizers on the Surface of Polypropylene : Atomic Force Microscopy with Chemically Modified Tips
Duwez, Anne-Sophie ULg; Poleunis, Claude; Bertrand, Patrick et al

in Langmuir (2001), 17

We show in this paper that it is possible to locally detect additives on the surface of polypropylene with chemically modified atomic force microscopy (AFM) tips. Gold-coated AFM tips modified with methyl ... [more ▼]

We show in this paper that it is possible to locally detect additives on the surface of polypropylene with chemically modified atomic force microscopy (AFM) tips. Gold-coated AFM tips modified with methyl and hydroxyl terminated self-assembled alkanethiol monolayers were used to measure adhesion forces on a process-stabilizing agent (Irgafos 168), an antioxidant (Irganox 1010), and UV-light stabilizers (Tinuvin 770, Dastib 845, Chimassorb 944, and Hostavin N30). Pull-off force measurements carried out on these pure additive films have shown that it is possible to discriminate between antioxidants and UV-light stabilizers. We have evidenced a characteristic fingerprint for each additive, according to the functionality of the tip used and themediumwherein the force measurements are realized (water or nitrogen atmosphere). Similarly we have measured pull-off forces on a melt-pressed polypropylene sample stabilized with Irgafos 168, Irganox 1010, and Tinuvin 770. These adhesion force measurements show that the extreme surface of the polymer is mainly made of a layer of Tinuvin 770. These results have been compared to those obtained from time-of-flight secondary ion mass spectrometry measurements [less ▲]

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See detailOn the exact solutions of the Lipkin-Meshkov-Glick model
Debergh, N.; Stancu, Floarea ULg

in Journal of Physics : A Mathematical & General (2001), A34

We present the many-particle Hamiltonian model of Lipkin, Meshkov and Glick in the context of deformed polynomial algebras and show that its exact solutions can be easily and naturally obtained within ... [more ▼]

We present the many-particle Hamiltonian model of Lipkin, Meshkov and Glick in the context of deformed polynomial algebras and show that its exact solutions can be easily and naturally obtained within this formalism. The Hamiltonian matrix of each $j$ multiplet can be split into two submatrices associated to two distinct irreps of the deformed algebra. Their invariant subspaces correspond to even and odd numbers of particle-hole excitations. [less ▲]

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See detailDe l'utilisation pédagogique d'Internet dans l'enseignement secondaire
Hubert, Sylviane; Petit, Christelle; Demily, Fabian et al

in Point sur la Recherche en Education (Le) (2001)

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See detailFaut-il corriger les stenoses de l'artere femorale superficielle chez le patient claudicant?
VAN DAMME, Hendrik ULg; Quaniers, Janine ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2001), 56(9), 639-49

Infrainguinal arterial occlusive disease is very common at the age of 60 years or older. It remains often asymptomatic. In one third of cases, it results in claudication. Claudication is a benign symptom ... [more ▼]

Infrainguinal arterial occlusive disease is very common at the age of 60 years or older. It remains often asymptomatic. In one third of cases, it results in claudication. Claudication is a benign symptom that rarely necessitates surgery or endovascular intervention. Physical training and control of risk factors are sufficient in most cases to improve the walking performance. Nowadays, the authors do no longer perform femoropopliteal bypass grafting as a first choice treatment for intermittent claudication. Conservative treatment has gained widespread acceptance for infrainguinal atherosclerosis with moderate ischemia. What is the fate of the claudicant? How effective is exercise therapy? Should we broaden the indications for percutaneous angioplasty? What is the place of femoropopliteal bypass graft for claudication? The authors investigate these different questions by means of an extensive review of recent literature. Based on this review and on international consensus documents, they justify their conservative approach to claudication secondary to occlusive disease of the superficial femoral artery. [less ▲]

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See detailLe martin-pêcheur (Alcedo atthis) va-t-il bientôt manquer de sites de nidification ?
Libois, Roland ULg

in Aves (2001), 38(4), 161-178

In south-west Belgium, the breeding of the kingfisher was monitored for more than 10 years. During this period, 158 banks were regularly surveyed. Alterations or potential threats were identified: natural ... [more ▼]

In south-west Belgium, the breeding of the kingfisher was monitored for more than 10 years. During this period, 158 banks were regularly surveyed. Alterations or potential threats were identified: natural erosion, cattle trampling, disturbance from kayak-riders or anglers and, last but not least, consolidation works. Only 56 banks (35.4 %) can de considered as "safe". However, since the recent (2001) legal restrictions about the navigation on small rivers, 12 more banks are now safe too. Cattle trampling appears as the main threat (55 sites). However, the enforcement of the law regulating the fences along the rivers could easily solve the problem. Nineteen banks were completely destroyed for different purposes: navigation, road retaining walls or simply anti-erosive measures. Most of these works were undertaken along the river Meuse, the best nidification habitat of the area. (11 photos) [less ▲]

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See detailImmunocytochemistry of the golden hamster pituitary during chronic administration of diethylstilbestrol: a quantitative analysis using laser scanning microscopy
Van Cauwenberge, A.; Nonclercq, D.; Laurent, G. et al

in Histochemistry & Cell Biology (2001), 115

The aim of this study was to examine by immunohistochemistry the morphologic changes affecting pituitary cell populations in male Syrian hamsters undergoing chronic exposure (3 days to 9 months) to ... [more ▼]

The aim of this study was to examine by immunohistochemistry the morphologic changes affecting pituitary cell populations in male Syrian hamsters undergoing chronic exposure (3 days to 9 months) to diethylstilbestrol (DES). Cell proliferation in the hypophysis was monitored by the immunohistochemical demonstration of S-phase cells after pulse labeling with 5-bromo-2'-deoxyuridine. Cell proliferation analysis was combined with the identification of different cell populations by immunostaining with antisera raised against hypophyseal hormones. Sections processed for double-label immunofluorescence were examined by confocal microscopy. In the adenohypophysis, the relative surface occupied by gonadotrophs and thyrotrophs decreased rapidly during the first months of treatment while corticotroph and somatotroph populations remained unaffected. Accordingly, the incidence of S-phase cells in these four cell populations was lower than or similar to control values. In contrast, lactotrophs increased gradually during the first month of exposure to DES to reach a maximum value at 2-4 months. At the beginning, this increase was primarily due to hyperplasia but later on it also involved cellular hypertrophy. Somatomammotrophs did not seem to be involved in this model. In the pars intermedia, the labeling index of melanotrophs rose rapidly to reach values 5-6 times higher than controls. After 4 months, neoplasms originating from the pars intermedia were seen invading both the neuro- and the adenohypophysis. At the end of treatment, the pituitary was markedly enlarged resulting from the development of an adenoma of the pars intermedia [less ▲]

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See detailCalculated transition probabilities in highly charged Ti-like ions
Biémont, Emile ULg; Träbert, E.; Zeippen, C. J.

in Journal of Physics : B Atomic Molecular & Optical Physics (2001), 34

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See detailS179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist
Bernichtein, Sophie; Kinet, Sandrina; Jeay, Sébastien et al

in Endocrinology (2001), 142(9), 3950-63

For many years, our group has been involved in the development of human PRL antagonists. In two recent publications, S179D-human PRL, a human PRL analog designed to mimic a putative S179-phosphorylated ... [more ▼]

For many years, our group has been involved in the development of human PRL antagonists. In two recent publications, S179D-human PRL, a human PRL analog designed to mimic a putative S179-phosphorylated human PRL, was reported to be a highly potent antagonist of human PRL-induced proliferation and signaling in rat Nb2 cells. We prepared this analog with the aim of testing it in various bioassays involving the homologous, human PRL receptor. In our hands, S179D- human PRL was able to stimulate 1) the proliferation of rat Nb2 cells and of human mammary tumor epithelial cells (T-47D), 2) transcriptional activation of the lactogenic hormone response element-luciferase reporter gene, and 3) activation of the Janus kinase/signal transducer and activator of transcription and MAPK pathways. Using the previously characterized antagonist G129R-human PRL as a control, we failed to observe any evidence for antagonism of S179D-human PRL toward any of the human PRL-induced effects analyzed, including cell proliferation, transcriptional activation, and signaling. In conclusion, our data argue that S179D-human PRL is an agonist displaying slightly reduced affinity and activity due to local alteration of receptor binding site 1, and that the antagonistic properties previously attributed to S179D-human PRL cannot be confirmed in any of the assays analyzed in this study. [less ▲]

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See detailPharma-clinics. Le medicament du mois. Le celecoxib (Celebrex).
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(1), 53-5

Celecoxib (Celebrex, Pharmacia) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as nonsteroidal anti-inflammatory drug (NSAID). Its current indications are ... [more ▼]

Celecoxib (Celebrex, Pharmacia) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as nonsteroidal anti-inflammatory drug (NSAID). Its current indications are osteoarthritis and rheumatoid arthritis. The usual recommended daily dosage of celecoxib is 200 mg (in one or two intakes per day), to be increased up to 400 mg (two intakes per day) if necessary. Its clinical efficacy seems to be similar to that of other NSAIDs. However, its safety profile, especially gastro-intestinal tolerance and perhaps renal safety, is much better because of the COX-2 selectivity. [less ▲]

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See detailThe lipid phosphatase SHIP2 controls insulin sensitivity
Clément, S.; Krause, U.; Desmedt, F. et al

in Nature (2001), 409

Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain ... [more ▼]

Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family. In vitro studies have shown that SHIP2, in response to stimulation by numerous growth factors and insulin, is closely linked to signalling events mediated by both phosphoinositide-3-OH kinase and Ras/mitogen-activated protein kinase. Here we report the generation of mice lacking the SHIP2 gene. Loss of SHIP2 leads to increased sensitivity to insulin, which is characterized by severe neonatal hypoglycaemia, deregulated expression of the genes involved in gluconeogenesis, and perinatal death. Adult mice that are heterozygous for the SHIP2 mutation have increased glucose tolerance and insulin sensitivity associated with an increased recruitment of the GLUT4 glucose transporter and increased glycogen synthesis in skeletal muscles. Our results show that SHIP2 is a potent negative regulator of insulin signalling and insulin sensitivity in vivo [less ▲]

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See detailA propos du remplage de la verrière d'Esther.
Morard, Thomas ULg

in Arte Cristiana (2001), 89(802), 23-30

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See detailTopically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis.
Nusgens, Betty ULg; Humbert, Philippe; Rougier, André et al

in Journal of Investigative Dermatology (2001), 116(6), 853-9

Ascorbic acid (vitamin C) is a cofactor required for the function of several hydroxylases and monooxygenases. It is not synthesized in humans and some other animal species and has to be provided by diet ... [more ▼]

Ascorbic acid (vitamin C) is a cofactor required for the function of several hydroxylases and monooxygenases. It is not synthesized in humans and some other animal species and has to be provided by diet or pharmacologic means. Its absence is responsible for scurvy, a condition related in its initial phases to a defective synthesis of collagen by the reduced function of prolylhydroxylase and production of collagen polypeptides lacking hydroxyproline, therefore, they are unable to assemble into stable triple-helical collagen molecules. In fibroblast cultures, vitamin C also stimulates collagen production by increasing the steady-state level of mRNA of collagen types I and III through enhanced transcription and prolonged half-life of the transcripts. The aim of the experimental work has been to evaluate the effect on dermal cells of a preparation of vitamin C topically applied on one side vs placebo on the other side of the dorsal face of the upper forearm of postmenopausal women. Biopsies were collected on both sides and the level of mRNA measured by non competitive reverse transcription-polymerase chain reaction made quantitative by the simultaneous transcription and amplification of synthetic RNA used as internal standards. The mRNA of collagen type I and type III were increased to a similar extent by vitamin C and that of three post-translational enzymes, the carboxy- and amino-procollagen proteinases and lysyloxidase similarly increased. The mRNA of decorin was also stimulated, but elastin, and fibrillin 1 and 2 were not modified by the vitamin. The expression of matrix metalloproteinases 1, 2, and 9 was not significantly changed, but an increased level of tissue inhibitor of matrix metalloproteinase 1 mRNA was observed without modification of tissue inhibitor of matrix metalloproteinase 2 mRNA. The stimulating activity of topical vitamin C was most conspicuous in the women with the lowest dietary intake of the vitamin and unrelated to the level of actinic damage. The results indicate that the functional activity of the dermal cells is not maximal in postmenopausal women and can be increased. [less ▲]

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See detailNatural radiative lifetimes in Ce II
Zhang, Z. G.; Svanberg, S.; Jiang, Z. et al

in Physica Scripta (2001), 63

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See detailnote sous J. P. Beveren, 7 avril 1998
Langenaken, Evelyne ULg

in Actualités du droit (2001), 2

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See detailPharmacology of the Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor Bm-531
Dogné, J. M.; Rolin, S.; de Leval, X. et al

in Cardiovascular Drug Reviews (2001), 19(2, Summer), 87-96

BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its ... [more ▼]

BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its affinity for human washed platelet TXA2 receptors labeled with [3H]SQ-29548 (IC50 = 0.0078 microM) is higher than sulotroban (IC50 = 0.93 microM) and SQ-29548 (IC50 = 0.021 microM). Moreover, BM-531 is characterized by a potent antiaggregatory property. Indeed, on one hand, in human citrated platelet-rich plasma BM-531 prevents platelet aggregation induced by arachidonic acid (600 microM) (ED100 = 0.125 microM), U-46619, a stable TXA2 agonist (1 microM) (ED50 = 0.482 microM) or collagen (1 microgram/mL) (percentage of inhibition: 42.9% at 10 microM) and inhibits the second wave of ADP (2 microM)-induced aggregation. On the other hand, when BM-531 is incubated in whole blood from healthy donors, the closure time measured by the recently developed platelet function analyser (PFA-100) is significantly prolonged. In addition, at the concentrations of 10 and 1 microM, BM-531 totally prevents the production of TXB2 by human platelets activated by arachidonic acid. Finally, at 10 microM, BM-531 significantly prevents rat fundus contractions induced by U-46619 but not by prostacyclin. These results suggest that BM-531, which is devoid of the diuretic property of torasemide, can be regarded as a promising antiplatelet agent. [less ▲]

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See detailOne-dimensional modelling of the plankton ecosystem of the north-western Corsican coastal area in relation to meteorological constraints
Skliris, Nikos; Elkalay, Khalid; Goffart, Anne ULg et al

in Journal of Marine Systems (2001), 27

In order to study the influence of wind mixing on the spring variability of the plankton production of the north western Corsican coastal area, a one-dimensional (1D), vertical, coupled hydrodynamic ... [more ▼]

In order to study the influence of wind mixing on the spring variability of the plankton production of the north western Corsican coastal area, a one-dimensional (1D), vertical, coupled hydrodynamic / biological model (ECOHYDROMV) is used. A hydrodynamic 1D model of the water column with a k–l turbulent closure is applied. The biological model comprises six state variables, representing the plankton ecosystem in the spring period: phytoplankton, copepods, nitrate, ammonium, particulate organic matter of phytoplanktonic origin and particulate organic matter of zooplanktonic origin. The system is influenced by turbulence (expressed by the vertical eddy diffusivity), temperature and irradiance. The model takes into account momentum and heat surface fluxes computed from meteorological data in order to simulate a typical spring atmospheric forcing for the considered area. Results show that primary production vertical structure is characterised by a subsurface maximum which deepens with time and is regulated by the opposite gradients of nitrate concentration and irradiance. Surface plankton productivity is mainly controlled by turbulent vertical transport of nutrients into the mixed layer. The short time scale variability of turbulent mixing generated by the wind appears to be responsible for the plurimodal shape of plankton blooms, observed in the considered area. Furthermore, the model is applied to the study of the spring evolution of the plankton communities off the bay of Calvi (Corsica) for the years 1986 and 1988. In order to initiate and validate the model, time series of hydrological, chemical and biological data have been used. The model reproduces accurately the spring evolution of the phytoplankton biomass measured in situ and illustrates that its strong variability in those years was in close relation to the variability of the wind intensity. [less ▲]

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See detailSerum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria.
Verhoef, H.; West, C. E.; Ndeto, P. et al

in American Journal of Clinical Nutrition (2001), 74(6), 767-75

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum ... [more ▼]

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum transferrin receptor concentrations are not or are only marginally influenced by the inflammatory response to infection. OBJECTIVE: We assessed iron status and examined the relation between serum transferrin receptor concentrations and malaria in children aged 2-36 mo who were asymptomatic for malaria. DESIGN: This was a community-based cluster survey (n = 318). RESULTS: Prevalences of malaria, anemia (hemoglobin concentration <110 g/L), iron deficiency (serum ferritin concentration <12 microg/L), and iron deficiency anemia were 18%, 69%, 53%, and 46%, respectively. Malaria was associated with lower mean hemoglobin concentrations (92.7 compared with 104.1 g/L; P = 0.0001) and higher geometric mean serum concentrations of transferrin receptor (11.4 compared with 7.8 mg/L; P = 0.005), ferritin (21.6 compared with 11.9 microg/L; P = 0.05), and C-reactive protein (12.5 compared with 6.8 mg/L; P = 0.004). There was no evidence for an association between serum concentrations of C-reactive protein and transferrin receptor. Children with malaria had higher serum transferrin receptor concentrations than expected for the degree of anemia, even after adjustment for inflammation indicated by serum C-reactive protein concentration quartiles (P = 0.02). CONCLUSIONS: Our findings are consistent with the notion that malaria-induced hemolysis is accompanied by increased erythropoiesis. Serum transferrin receptor concentration is not useful for detecting iron deficiency in individuals with malaria. Individuals with high concentrations of serum C-reactive protein or similar acute phase reactants should be excluded from analysis if serum ferritin concentrations <12 microg/L are to be used to measure iron deficiency in malaria-endemic areas. [less ▲]

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See detailDendritic cells induce the death of human papillomavirus-transformed keratinocytes
Hubert, Pascale ULg; Giannini, Sandra ULg; Vanderplasschen, Alain ULg et al

in FASEB Journal (2001), 15(13), 2521-2523

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See detailContinuité de l'information, discontinuités sociales: NTIC, nouvelles formes d'organisation et dialogue social
Schoenaers, Frédéric ULg; Zune, Marc

in Revue de Gestion des Ressources Humaines (2001), 42

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See detailPhenotypic analysis of strains deleted for genes with unknown function: data and general reasoning.
Bianchi, M.; Sartori, G.; Vandenbol, Micheline ULg et al

in Yeast (Chichester, England) (2001), 18(S97), 5-31

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See detailL'image du mois. Perte de l'arythmie sinusale respiratoire dans la neuropathie autonome diabetique.
Scheen, André ULg; Geronooz, I.; Philips, Jean-Christophe ULg et al

in Revue Médicale de Liège (2001), 56(10), 669-70

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See detailFine-mapping and construction of a bovine contig spanning the ovine callipyge locus.
Shay, T. L.; Berghmans, S.; SEGERS, Karin ULg et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (2001), 12(2), 141-9

The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human ... [more ▼]

The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human HSA14q transcript map were aligned by genotyping two bovine-hamster whole-genome radiation hybrid panels with the microsatellite markers, as well as with sequences corresponding to HSA 14q genes. Using Type I loci mapping to the IDVGA30-OY3 interval as anchor points, we have constructed a 1.4-Mb bovine BAC contig containing the IDVGA30-OY3 interval. We demonstrate that the IDVGA30-OY3 interval spans approximately 770 kb and contains at least four genes: YY1, WARS, DLK1, and GTL2. [less ▲]

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See detailL'etude clinique du mois. Toxicite de l'hyperglycemie en soins intensifs et effets benefiques d'une insulinotherapie optimisee.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(12), 859-61

A large Belgian, prospective, controlled study was performed in 1.548 critically ill patients (83% without history of diabetes) hospitalised in a surgical intensive care unit. On admission, patients were ... [more ▼]

A large Belgian, prospective, controlled study was performed in 1.548 critically ill patients (83% without history of diabetes) hospitalised in a surgical intensive care unit. On admission, patients were randomly assigned to receive intensive intravenous insulin therapy (maintenance of blood glucose at a level between 80 and 110 mg/dl) or conventional treatment (infusion of insulin only if the blood glucose level exceeded 215 mg/dl and maintenance of glucose at a level between 180 and 200 mg/dl). Intensive insulin therapy reduced morbidity and mortality by 40%. These remarkable results should influence further therapeutical attitudes in intensive care units and open new perspectives for the management of critically ill patients. [less ▲]

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See detailCommerce de détail, loisirs et tourisme : vers un renforcement des liens ?
Merenne-Schoumaker, Bernadette ULg

in Hommes et Terres du Nord (2001), (2001/2), 90-96

The aim of this article is to analyze the recent evolution of the links between the retail trade and the activities of leisures and tourism. For this purpose, work was organized in three times: initially ... [more ▼]

The aim of this article is to analyze the recent evolution of the links between the retail trade and the activities of leisures and tourism. For this purpose, work was organized in three times: initially, studying of the effects induced on the retail trade by tourism and the leisures; then, analyzing of two new forms of trade (shopping centres and factory outlets malls) which seem today to Induce displacements of leisure and tourism to the same title sometimes as some city centers; then searching for an explanation. For us, the emergence of the places of trade as " entertaining resources " results from increasingly strong convergence on certain places of new waitings of the consumers and the charac-teristics of the offer suggested by the promoters. [less ▲]

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See detailPetrology and geochemistry of rapakivi-type granites from the crystalline basement of NE Poland
Baginski, Boguslaw; Duchesne, Jean-Clair ULg; Vander Auwera, Jacqueline ULg et al

in Geological Quarterly (2001), 45(1), 33-52

The collection of 80 rock samples coming from drillcores of 8 localities from the Mazury Complex (Polish part of the crystalline East European Craton) and representing different rock types from ... [more ▼]

The collection of 80 rock samples coming from drillcores of 8 localities from the Mazury Complex (Polish part of the crystalline East European Craton) and representing different rock types from monzodiorites to leucogranites, were studied for major, trace and REE elements by XRF and ICP-MS methods. The range in composition of investigating rocks varies from 46% to 76% SiO2 contents. All of them show similar REE distributions, what suggests that they are genetically linked. They also plot along a major trend with many similarities to the jotunitic liquid line of descent (LLD) defined in AMCG rocks from Rogaland (Norway). Each group of rocks has however its own characteristics considering specific elements, such as REE, Sr or Zr. [less ▲]

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See detailA psycho-endocrinological overview of transsexualism
Michel, Aude; Mormont, Christian ULg; Legros, Jean-Jacques ULg

in European Journal of Endocrinology (2001), 145(4), 365-376

The technical possibility of surgical sex change has opened up a debate concerning the legitimacy and utility of carrying out such an intervention at the request of the transsexual. Diagnostic ... [more ▼]

The technical possibility of surgical sex change has opened up a debate concerning the legitimacy and utility of carrying out such an intervention at the request of the transsexual. Diagnostic, psychological, medical and ethical arguments have been brought forth, both for and against. Nonetheless, anatomical transformation by surgical means has currently become a practice as the frequency of serious gender identity disorders is constantly progressing. After a brief introduction, the present paper will consider typological, aetiological and epidemiological aspects of transsexualism. Treatment of the sex change applicant is then defined and discussed in terms of psychological, psychiatric, endocrinological and surgical aspects. Finally, the question of post-operation follow-up will be examined. [less ▲]

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See detailComparison between Solution-Phase Stability and Gas-Phase Kinetic Stability of Oligodeoxynucleotide Duplexes
Gabelica, Valérie ULg; De Pauw, Edwin ULg

in Journal of Mass Spectrometry [=JMS] (2001), 36(4), 397-402

The relative kinetic stabilities of different 16-mer oligonucleotide duplexes were investigated by source collision-induced dissociation (CID) in a heated capillary electrospray ion source. They were ... [more ▼]

The relative kinetic stabilities of different 16-mer oligonucleotide duplexes were investigated by source collision-induced dissociation (CID) in a heated capillary electrospray ion source. They were compared with the relative stabilities in solution obtained by thermal denaturation monitored by UV spectrophotometry. The results clearly show that both hydrogen bonding and base stacking interactions that are present in solution are maintained in the gas phase. This suggests that the electrospray process preserves the double-helix structure of DNA. A step by step opening of the double helix structure is proposed for the gas-phase dissociation, competing with the covalent bond cleavage of bases. We also draw attention to the fact that by source CID, it is the kinetic stability of the complexes that is probed. In particular, this implies that only complexes of the same size can be compared. [less ▲]

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See detailIn vitro tubulogenesis of endothelial cells by relaxation of the coupling extracellular matrix-cytoskeleton.
Deroanne, Christophe ULg; Lapiere, C. M.; Nusgens, Betty ULg

in Cardiovascular Research (2001), 49(3), 647-58

OBJECTIVE: This investigation aimed at determining the importance of the rigidity of the adhesive support and the participation of the cytoskeleton in tubulogenesis of endothelial cells in vitro. METHODS ... [more ▼]

OBJECTIVE: This investigation aimed at determining the importance of the rigidity of the adhesive support and the participation of the cytoskeleton in tubulogenesis of endothelial cells in vitro. METHODS: The morphotype, biosynthetic phenotype and cytoskeleton organization of human umbilical vein endothelial cells (HUVEC) were analyzed on supports of variable mechanical resistance. RESULTS: Western blot analysis revealed a strong reduction of the expression of actin and focal-adhesion plaque (FAP) proteins in HUVEC organized in tube-like structures (TLS) on soft matrigel or on matrigel co-polymerized with heat-denatured collagen as compared to HUVEC remaining in a monolayer pattern on rigid matrigel-coat or on matrigel co-polymerized with type I collagen. Human skin fibroblasts morphotype was not altered in these culture conditions and the pattern of FAP proteins and actin was not modulated. By using polyacrylamide gels polymerized with various concentrations of bis-acrylamide to modulate the mechanical resistance of the support and cross-linked to a constant amount of gelatin to provide an equal density of attachment sites, it was shown that the less rigid the support, the more endothelial cells switched to a tube-like pattern. Collagen type I-induced tubulogenesis was accompanied by a profound and reversible remodeling of the actin-FAP complex suggesting a weakening of the bridging between extracellular matrix (ECM) and the cytoskeleton. Human skin fibroblasts and smooth muscle cells, used as control cells, adhered strongly to the collagen, did not form TLS and their network of actin stress fibers was not remodeled. The inhibition of collagen type I-induced tubulogenesis by agents altering the actin cytoskeleton-FAP complex including calpain type I inhibitor, orthovanadate, KT5720 and jasplakinolide, further supports the determinant role of mechanical coupling between the cells and the matrix in tubulogenesis. CONCLUSIONS: A reduced tension between the endothelial cells and the extracellular matrix, originating in the support or within the cells is sufficient to trigger an intracellular signaling cascade leading to tubulogenesis, an event mimicking one of the last steps of angiogenesis. [less ▲]

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See detailCardiac surgery in octogenarians: who, when and how?
Pierard, Luc ULg

in European heart journal (2001), 22(14), 1159-61

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See detailJe lis, j'écris : la pratique du journal de lecture
De Croix, Séverine ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (2001), 50

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See detailHeroic Fantasy et modernité: la problématique de la quête chez Michael Moorcock et Samuel R. Delany
Delville, Michel ULg

in Sources: Revue d'Etudes Anglophones (2001), 11

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See detailEndothelin in the equine hypoxic pulmonary vasoconstrictive response to acute hypoxia
Benamou, A. E.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal (2001), 33(4), 345-353

Elevated concentrations of endothelin (ET), a potent endothelium-derived vasoactive peptide, have been reported in a number of pathophysiological conditions associated with pulmonary hypertension, both in ... [more ▼]

Elevated concentrations of endothelin (ET), a potent endothelium-derived vasoactive peptide, have been reported in a number of pathophysiological conditions associated with pulmonary hypertension, both in the horse and other species. We have previously shown, both in vitro and in vivo, that the pulmonary and systemic vascular response to exogenous ET is mediated predominantly via ET(A) receptors. Our hypothesis in the present study was that ET is involved in the equine hypoxic pulmonary vasoconstrictive response to acute hypoxia. In this study, we investigated the effects of a selective ET(A) receptor antagonist on hypoxic pulmonary hypertension in the mature horse. Horses were exposed to a 10 min period of hypoxia (F(I)O2 approximately 0.11) on 2 occasions, with and without pretreatment with the selective ET(A) receptor antagonist TBC11251 (10 mg/kg bwt i.v.). Hypoxia increased mean pulmonary artery pressure (PAP) from 18.3+/-0.9 (mean +/- s.e. normoxia) to 28.0+/-0.8 mmHg (hypoxia) in the session without ET(A) receptor antagonism. Carotid arterial pressure (CAP) also increased progressively throughout the period of hypoxic challenge and at the end was 153+/-5 mmHg (hypoxia) compared to during normoxia (140+/-5 mmHg). There was no significant overall effect of ET(A) receptor antagonism on the haemodynamic or ventilatory responses to acute hypoxia. However, between 5 and 10 min of hypoxia there was a trend for the mean PAP to diverge in the 2 treatments, which just failed to reach significance at 10 min of hypoxia (P = 0.053). In conclusion, this study describes the haemodynamic and ventilatory changes in response to a period of acute hypoxia in the adult horse. The results do not support a role for ET as a mediator of acute HPV in the horse, but suggest that it may be involved as a modulator or in the slower (>10 min) phase of HPV. [less ▲]

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