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See detailLes décrets oraculaires pris en l’honneur d’Hénouttaouy et de Maatkarê (Xe et VIIe pylônes)
Winand, Jean ULiege

in Cahiers de Karnak (2003), (11), 603-710

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : I) les adhésines et facteurs de colonisation
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 105-126

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, enterohaemmorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections): If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains: adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This first manuscript presents the current knowledge on the receptors, roles in pathogenesis, structures, genetic determinism and identification methods of fimbrial adhesins of P (Pap, Prs), S (Sfa, F1C, Sfr) and F17 (Vir, Att25, FY, 20K, G, Att111) families and of afimbrial adhesins of Afa family (Afa, Nfa, F1845, Bma, Dr...). [less ▲]

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See detailRilke herlezen
Spinoy, Erik ULiege

in Freespace Nieuwzuid (2003), 3(12), 80

In this special issue, a number of critics reflect on the question if and how it is still possible today to take great lyrical poetry at face value. The case at hand is that of Rilke's Duino Elegies.

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See detailInositol 1,3,4,5-tetrakisphosphate is essential for normal T lymphocyte development
Pouillon, V.; Hascakova-Bartova, R.; Pajak, B. et al

in Nature Immunology (2003), 4

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4 ... [more ▼]

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4) is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5)P(3) amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development [less ▲]

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See detailInfluence of a nonlinear reference temperature profile on oscillatory Benard-Marangoni convection.
Dondlinger, M.; Colinet, P.; Dauby, Pierre ULiege

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2003), 68(6 Pt 2), 066310

We analyze oscillatory instabilities in a fluid layer of infinite horizontal extent, heated from above or cooled from below, taking into account the nonlinearity of the reference temperature profile ... [more ▼]

We analyze oscillatory instabilities in a fluid layer of infinite horizontal extent, heated from above or cooled from below, taking into account the nonlinearity of the reference temperature profile during the transient state of heat conduction. The linear stability analysis shows that a nonlinear reference temperature profile can have a strong effect on the system, either stabilizing or destabilizing, depending on the relative importance of buoyancy and surface tension forces. For the nonlinear analysis we use a Galerkin-Eckhaus method leading to a finite set of amplitude equations. In the two-dimensional (2D) case, we show the solution of these amplitude equations are standing waves. [less ▲]

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See detailMycoplasma bovis : synthèse des connaissances actuelles
Thomas, Anne; Mainil, Jacques ULiege; Linden, Annick ULiege

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 23-39

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia ... [more ▼]

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia, arthritis and mastitis, and is thus associated with strong economic losses. Several studies have shown the frequency of M. bovis in Europe and the spread of antibiotic-resistant strains. Considering the absence of vaccine in Europe, it is essential to understand this bacteria in order to control the infection in cattle. In this context, this paper aims at summarizing the current knowledge about M. bovis. [less ▲]

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See detailRezension zu Silke Schlichtmann: Geschlechterdifferenz in der Literaturrezeption um 1800? Zu zeitgenössischen Goethe-Lektüren
Pontzen, Alexandra ULiege

in Arbitrium: Zeitschrift fuer Rezensionen zur germanistischen Literaturwissenschaft (2003)

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See detailDendrochronologie et archéologie du bâtiment
Hoffsummer, Patrick ULiege

in Cahiers de l'Urbanisme (Les) (2003), 44

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See detailEffets de la nicotine et du cannabis sur le systeme nerveux central.
Seutin, Vincent ULiege

in Revue Médicale de Liège (2003), 58(1), 19-21

We describe the molecular mechanisms of action of nicotine and delta 9-tetrahydrocannabinol, the most potent component of cannabis. Like other drugs of abuse, these compounds enhance dopamine release in a ... [more ▼]

We describe the molecular mechanisms of action of nicotine and delta 9-tetrahydrocannabinol, the most potent component of cannabis. Like other drugs of abuse, these compounds enhance dopamine release in a precise area of the limbic system when administered acutely. It has recently been shown that the cannabinoid receptors on which delta 9-tetrahydrocannabinol acts are also activated by endogenous ligands such as anandamide. This unconventional neurotransmitter appears to have important physiological effects in the central nervous system. Both preclinical and clinical evidence suggests that nicotine is more addictive than delta 9-tetrahydrocannabinol. However, the intimate interactions that exist between cannabinoid and opioid systems within the brain suggest that cannabinoids should not be considered as harmless drugs of abuse. [less ▲]

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See detailKeys to promote Good Practices in ODL by a TECC Approach (Training Embedded Coached Course Construction): Illustrations through a Postgraduate Degree and an Annual Competitive Call
Poumay, Marianne ULiege

in Educational Media International (2003), 40(3-4), 229-237

The article presents two parallel initiatives contributing to an open and distance learning (ODL) deployment, comparing them using the LabSET Keys to implement a Training Embedded Coached Course ... [more ▼]

The article presents two parallel initiatives contributing to an open and distance learning (ODL) deployment, comparing them using the LabSET Keys to implement a Training Embedded Coached Course Construction (TECCC) approach. The article examines some of the challenges faced by the support to trainers using the Web as an instructional tool to facilitate learner-centered practices. It includes a definition of "quality courses". [less ▲]

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See detailFrom the germinal cells to the newborn animal: The transmission of genes and life through the generations
Drion, Pierre ULiege; Szenci, Otto; Ectors, Fabien ULiege et al

in Acta Veterinaria Hungarica (2003), 51(3), 371-384

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most ... [more ▼]

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most spectacular manipulations are cloning and transgenesis. This review focuses on the early appearance of germinal cell precursors and the long-standing fate of gametes in mammals. The evident complexity and long-term programming of events in gametes and early embryos explain part of the difficulties encountered during the development of in vitro and in vivo methods such as multiple Ovulation and embryo transfer (MOET), oestrus synchronisation, ovulation induction, superovulation, in vitro maturation and fertilisation, cryopreservation, transgenesis, nuclear transfer and cloning) and the occurrence of unexpected alterations of development, e.g. embryonic or fetal mortality, large-weight newborn syndrome and other dysregulations ill imprinting or DNA transmission. [less ▲]

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See detailEnantiomeric separation of aminoglutethimide by capillary electrophoresis using native cyclodextrins in single and dual systems
Abushoffa, A. M.; Fillet, Marianne ULiege; Marini Djang'Eing'A, Roland ULiege et al

in Journal of Separation Science (2003), 26(6-7), 536-542

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A ... [more ▼]

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A complete resolution of the enantiomers of this compound in cationic form could be achieved with each of the three CDs, using a pH 3 phosphoric acid-triethanolamine buffer. Affinity constants for AGT enantiomers with the three native CDs were determined, confirming that the highest selectivity was given by gamma-CD while the strongest complexation was obtained with beta-CD. However, an opposite affinity pattern was observed with the latter. Selectivity was lower for AGT enantiomers in dual CD systems, compared to that obtained with a single selector at its optimal concentration, which confirms that dual systems are of more limited interest when the two selectors have a similar effect on the analyte mobility. These results are in good agreement with those predicted using recently developed mathematical models. [less ▲]

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See detailEGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.
Teramoto, Tetsuyuki; Qiu, Jianhua; Plumier, Jean-Christophe ULiege et al

in Journal of Clinical Investigation (2003), 111(8), 1125-32

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that ... [more ▼]

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-labeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair. [less ▲]

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See detailFactor V inhibitor after injection of human thrombin in a bleeding ulcer.
Caers, Jo ULiege; Reekmans, An; Jochmans, Kristin et al

in Endoscopy (2003), 35((6)), 542-4

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See detailProcessing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.
De Cat, Bart; Muyldermans, Sin*-Ya; Coomans, Christien et al

in Journal of Cell Biology (2003), 163(3), 625-35

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 ... [more ▼]

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 core protein is processed by a furinlike convertase. This processing is essential for GPC3 modulating Wnt signaling and cell survival in vitro and for supporting embryonic cell movements in zebrafish. The processed GPC3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical Wnt signaling additionally require substitution of the core protein with heparan sulfate. Wnt 5A physically associates only with processed GPC3, and only a form of GPC3 that can be processed by a convertase is able to rescue epiboly and convergence/extension movements in GPC3 morphant embryos. Our data imply that the Simpson-Golabi-Behmel syndrome may in part result from a loss of GPC3 controls on Wnt signaling, and suggest that this function requires the cooperation of both the protein and the heparan sulfate moieties of the proteoglycan. [less ▲]

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See detailOptimalisation de la prise en charge du patient diabetique de type 2: resultats de l'etude DREAM" en medecine generale."
Scheen, André ULiege; Bruwier, Geneviève ULiege; Schmitt, H.

in Revue Médicale de Liège (2003), 58(3), 139-46

This paper reports the results of the "DREAM" ("Diabetes REinforcement of Adequate Management") study performed among 42 general practitioners. A treatment algorithm was proposed to intensify the ... [more ▼]

This paper reports the results of the "DREAM" ("Diabetes REinforcement of Adequate Management") study performed among 42 general practitioners. A treatment algorithm was proposed to intensify the management of type 2 diabetic patients in case of poor control (HbA1C > 7.5% and fasting blood glucose > 140 mg/dl) before asking for an advice from a diabetologist. A total of 163 patients participated in the study: 84 men and 79 women, 59 +/- 10 years old; 5.2 +/- 6.1 years of known duration of diabetes; BMI: 30.7 +/- 5.8 kg/m2. Almost two thirds of patients received an antihypertensive agent, one third a lipid-lowering drug, and three quarters at least one antidiabetic agent: 22% a sulfonylurea, 18% metformin, 25% a combined oral therapy, 10% insulin (alone or in combination). At baseline, mean HbA1C averaged 7.1 +/- 2.2% (N: 4-6%), and 34% of patients had HbA1C > 7.5%. From these 163 patients, 100 were evaluated after 12 months, 57% being well controlled vs 36% at baseline. Among the 32 patients whose hypoglycaemic treatment was intensified, HbA1C level significantly decreased by almost 0.8% (p < 0.05). Despite precise guidelines, 55% of patients with HbA1C > 7.5% had no treatment adjustment, essentially in the group already on oral bitherapy or on insulin. Among the 65 patients evaluated after 24 months, the percentage of well controlled patients decreased to 44% (vs 51% after 12 months). The decision of switching to insulin was often delayed (no patient after 1 year and 2 patients only after 2 years). In conclusion, the "DREAM" study demonstrates the feasibility, but also the difficulty, of optimising the management of type 2 diabetic patients in general practice. [less ▲]

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : II) Franchissement des muqueuses et propriétés invasives
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(3, JUN-JUL), 159-171

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, entero-haemorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains : adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This second manuscript presents the current knowledge on the transmucosal transfer, resistance to the bactericidal activity of the complement, resistance to phagocytosis and production of colicins, that were, for several years, considered as an important specific property of invasive strains of E coli. [less ▲]

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See detailSyncope sur passage en tachycardie ventriculaire par accélération d’une fibrillation auriculaire
Guillaume, T.; Melon, Pierre ULiege; Bouffioux, Laurent ULiege et al

in Revue Médicale de Liège (2003), 58(7-8), 468-471

We report a rare case of rapid atrial fibrillation triggering an episod of ventricular tachycardia. We review the literature and discuss the potential mechanisms of the ventricular arrhythmia.

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See detailPhysiology of reproduction and endocrinology in cervids. A review
Drion, Pierre ULiege; Hanzen, Christian ULiege; Wirth, Delphine - in memoriam et al

in Annales de Médecine Vétérinaire (2003), 147(5), 291-313

Knowledge about cervids are rapidly growing. This work aims to present the more recent scientific information on reproductive physiology and endocrinology of the cervids: anatomy of the genital tract ... [more ▼]

Knowledge about cervids are rapidly growing. This work aims to present the more recent scientific information on reproductive physiology and endocrinology of the cervids: anatomy of the genital tract, length of breeding season, parameters and endocrinology of the reproductive cycle, endocrinology of pregnancy. It also aims to highlight differences between cervids and domestic ruminants such as embryonic diapause observed in Capreolus capreolus. [less ▲]

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See detailPreoperative hyperfractionated acclerated radiotherapy (HART) and concomittant CPT-11 in advanced rectal carcinoma. A phase I study.
Voelter, V; Stupp, R; Matter, M et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 56(5), 1288-1294

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated ... [more ▼]

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated radiotherapy (HART). In this Phase I trial, we aimed at introducing chemotherapy early in the treatment course with both intrinsic antitumor activity and a radiosensitizer effect. Methods and Materials: Twenty-eight patients (19 males; median age 63, range 28–75) with advanced rectal carcinoma (cT3: 24; cT4: 4; cN : 12; M1: 5) were enrolled, including 8 patients treated at the maximally tolerated dose. Escalating doses of CPT-11 (30–105 mg/m2/week) were given on Days 1, 8, and 15, and concomitant HART (41.6 Gy, 1.6 Gy bid 13 days) started on Day 8. Surgery was to be performed within 1 week after the end of radiochemotherapy. Results: Twenty-six patients completed all preoperative radiochemotherapy as scheduled; all patients underwent surgery. Dose-limiting toxicity was diarrhea Grade 3 occurring at dose level 6 (105 mg/m2). Hematotoxicity was mild, with only 1 patient experiencing Grade 3 neutropenia. Postoperative complications (30 days) occurred in 7 patients, with an anastomotic leak rate of 22%. Conclusions: The recommended Phase II dose of CPT-11 in this setting is 90 mg/m2/week. Further Phase II exploration at this dose is warranted. © 2003 Elsevier Inc. [less ▲]

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See detailBioactive capsular polysaccharide from the thermophilic Mastigocladus laminosus (Cyanophyceae/Cyanobacteria): demonstration of anti-inflammatory properties
Gloaguen, Vincent; Garbacki, Nancy ULiege; Petit, Daniel et al

in Algological Studies (2003), 108

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See detailPlmA, a new member of the GntR family, has plasmid maintenance functions in Anabaena sp. strain PCC 7120
Lee, M. H.; Scherer, K.; Rigali, Sébastien ULiege et al

in Journal of Bacteriology (2003), 185(15), 4315-4325

The filamentous cyanobacterium Anabaena (Nostoc) sp. strain PCC 7120 maintains a genome that is divided into a 6.4-Mb chromosome, three large plasmids of more that 100 kb, two medium-sized plasmids of 55 ... [more ▼]

The filamentous cyanobacterium Anabaena (Nostoc) sp. strain PCC 7120 maintains a genome that is divided into a 6.4-Mb chromosome, three large plasmids of more that 100 kb, two medium-sized plasmids of 55 and 40 kb, and a 5.5-kb plasmid. Plasmid copy number can be dynamic in some cyanobacterial species, and the genes that regulate this process have not been characterized. Here we show that mutations in an open reading frame, all1076, reduce the numbers of copies per chromosome of several plasmids. In a mutant strain, plasmids pCC7120delta and pCC7120zeta are both reduced to less than 50% of their wild-type levels. The exogenous pDU1-based plasmid pAM1691 is reduced to less than 25% of its wild-type level, and the plasmid is rapidly lost. The peptide encoded by all1076 shows similarity to members of the GntR family of transcriptional regulators. Phylogenetic analysis reveals a new domain topology within the GntR family. PlmA homologs, all coming from cyanobacterial species, form a new subfamily that is distinct from the previously identified subfamilies. The all1076 locus, named plmA, regulates plasmid maintenance functions in Anabaena sp. strain PCC 7120. [less ▲]

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See detailRéflexions sur l'idée de la "confiance mutuelle"
Flore, Daniel ULiege

in L'espace pénal européen (2003)

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See detailLes mycoplasmes respiratoires bovins: prévalence et propriétés de cyto-adhésion
Thomas, A.; Dizier, Isabelle ULiege; SACHSE, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 267-272

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See detailUn droit pénal européen : hasard ou nécessité
Flore, Daniel ULiege

in Revue de Droit Pénal et de Criminologie (2003), 9

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See detailUne approche par les compétences pour l’apprentissage des soins infirmiers. Analyse des pratiques des enseignants.
Dury, Cécile ULiege

in Recherche en Soins Infirmiers (2003), 73(Juin), 4-40

The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non ... [more ▼]

The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non-directive approach. The data were analysed with a qualitative method: "structural analysis method". The results showed that their methods are in majority in a transmissive and behavioral model; an inadequacy between teaching methods and pedagogical goals; an abivalent and unclear understanding of their role; a lack of coherence in the assesment methods. To conclude, various strategies are proposed on institutional and national levels to support the implementation of a competence-based approach in nursing training. [less ▲]

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See detailNieuwe Europese richtlijnen voor de behandeling van arteriele hypertensie: plaats van laaggedoseerde combinatiepreparaten
Krzesinski, Jean-Marie ULiege

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2003), 15(8), 295-299

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See detailEuropean COST action F3 on structural dynamics. Working group 3: identification of non-linear systems. Introduction and conclusions
Golinval, Jean-Claude ULiege; Kerschen, Gaëtan ULiege; Lenaerts, Vincent et al

in Mechanical Systems & Signal Processing (2003)

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See detailDevelopment Of A Scar Marker And A Semi-Selective Medium For Specific Quantification Of Pichia Anomala Strain K On Apple Fruit Surfaces
De Clercq, Deborah; Cognet, Stephane; Pujol, Marta et al

in Postharvest Biology & Technology (2003), 29(3), 237-247

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See detailNMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains.
Liepinsh, Edvards; Genereux, Catherine ULiege; Dehareng, Dominique ULiege et al

in Journal of Molecular Biology (2003), 327(4), 833-42

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway ... [more ▼]

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway for the acquisition of constitutive antibiotic resistance. Here, we report the NMR structure of AmpD from Citrobacter freundii (PDB accession code 1J3G). A deep substrate-binding pocket explains the observed specificity for low molecular mass substrates. The fold is related to that of bacteriophage T7 lysozyme. Both proteins bind zinc at a conserved site and require zinc for amidase activity, although the enzymatic mechanism seems to differ in detail. The structure-based sequence alignment identifies conserved features that are also conserved in the eukaryotic peptidoglycan recognition protein (PGRP) domains, including the zinc-coordination site in several of them. PGRP domains thus belong to the same fold family and, where zinc-binding residues are conserved, may have amidase activity. This hypothesis is supported by the observation that human serum N-acetylmuramyl-L-alanine amidase seems to be identical with a soluble form of human PGRP-L. [less ▲]

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See detailSystemic osmotic manipulations modulate ethanol-induced taurine release : a brain microdialysis study
Quertemont, Etienne ULiege; Devitgh, Audrey; De Witte, Philippe

in Alcohol (2003), 29(1), 11-19

In recent microdialysis studies, increased extracellular concentrations of taurine after high ethanol dose administration were identified in various rat brain regions. The mechanisms by which ethanol ... [more ▼]

In recent microdialysis studies, increased extracellular concentrations of taurine after high ethanol dose administration were identified in various rat brain regions. The mechanisms by which ethanol caused these increases in extracellular taurine concentration remained unclear but could be related to ethanol-induced cell swelling. The aim of the current study was to investigate whether changes in the body osmotic state modulate the effects of ethanol on brain extracellular taurine concentrations. In several groups of rats, brain hypoosmotic or hyperosmotic states were superimposed on acute ethanol (2.0-g/kg) injections, and extracellular taurine concentrations within the nucleus accumbens were assessed by using an intracerebral microdialysis procedure. A hypoosmotic state was obtained by systemic administration of water while hyperosmotic states were induced by intraperitoneal injections of hypertonic saline solutions (1.8% or 3.6% saline). In isoosmotic conditions, ethanol induced an immediate and significant increase in taurine microdialysate content, confirming results of previous studies. However, the effects of ethanol on taurine concentrations were modulated by osmotic manipulations. Hypoosmotic conditions significantly potentiated ethanol-induced taurine release. In contrast, ethanol-induced increases in extracellular taurine levels were attenuated by 1.8% saline injection and totally prevented by 3.6% saline administration. These results strongly argue in favor of a primary role, of osmoregulation in ethanol-induced taurine release. Ethanol-induced cell swelling probably activates volume-sensitive channels, and taurine passively diffuses outside the cells along its concentration gradient. (C) 2003 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailUltradispersity of diamond at the nanoscale
Raty, Jean-Yves ULiege; Galli, G.

in Nature Materials (2003), 2(12), 792-795795

Nanometre-sized diamond has been found in meteorites, protoplanetary nebulae, and interstellar dusts, as well as in residues of detonation and in diamond films. Remarkably, the size distribution of ... [more ▼]

Nanometre-sized diamond has been found in meteorites, protoplanetary nebulae, and interstellar dusts, as well as in residues of detonation and in diamond films. Remarkably, the size distribution of diamond nanoparticles seems to be peaked around 2-5 nm, and to be largely independent of preparation conditions. We have carried out ab initio calculations of the stability of nanodiamond as a function of surface hydrogen coverage and of size. We have found that at about 3 nm, and for a broad range of pressures and temperatures, particles with bare, reconstructed surfaces become thermodynamically more stable than those with hydrogenated surfaces, thus preventing the formation of larger grains. Our findings provide an explanation of the size distribution of extraterrestrial and of terrestrial nanodiamond found in ultradispersed and ultracrystalline diamond films. They also provide an atomistic structural model of these films, based on the topology and structure of 2-3 nm diamond clusters consisting of a diamond core surrounded by a fullerene-like carbon network [less ▲]

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See detailModeling of Thin Insulating Layers with Dual 3-D Magnetodynamic Formulations
Dular, Patrick ULiege; Geuzaine, Christophe ULiege

in IEEE Transactions on Magnetics (2003), 39(3), 1139--1142

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See detailL'urticaire et ses implications systémiques
Dezfoulian, Bita ULiege; Khalil, Z.; de LA BRASSINNE, Michel ULiege

in Revue Médicale de Liège (2003), 58(12), 751-756

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several ... [more ▼]

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several etiological, pathophysiological and therapeutic problems. We will develop the acute and chronic urticaria as well as their different associations with systemic diseases. Some current data concerning chronic idiopathic autoimmune urticaria is reviewed. The management and therapeutics will be discussed. [less ▲]

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See detailTotaal cardiovasculair risico: HOPE doet langer leven!
Krzesinski, Jean-Marie ULiege

in Tempo Médical (2003), 247

Cardiovasculaire aandoeningen blijven de belangrijkste doodsoorzaak bij volwassenen. Dat onderstreept het belang van een adequate behandeling van het risico, met name in de algemene geneeskunde. Oe meest ... [more ▼]

Cardiovasculaire aandoeningen blijven de belangrijkste doodsoorzaak bij volwassenen. Dat onderstreept het belang van een adequate behandeling van het risico, met name in de algemene geneeskunde. Oe meest recente aanbevelingen gaan steeds meer in de zin van een aanpak van het totale cardiovasculaire risico, waarbij minder belang wordt gehecht aan de absolute waarde van de atzonderlijke risicotactoren. Patienten met het grootste totale risico moeten uiteraard prioritair behandeld worden. Deze houding is gebaseerd op de resultaten van enkele grote klinische studies, waaronder HOPE (Heart Outcomes Prevention Evaluation). In dit artikel krijgt u een overzicht van de resultaten van deze opmerkelijke studie en een commentaar op deze nieuwe preventieve aanpak van het cardiovasculaire risico in het gezelschap van enkele sprekers op het congres Cardio 2003. [less ▲]

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See detailMycoplasma bovis dans le complexe respiratoire bovin et propriétés de cyto-adhésion in vitro
Thomas, Anne; Dizier, Isabelle ULiege; Sachse, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 267-272

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This ... [more ▼]

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This species was frequently isolated in Belgium from cattle with respiratory disease. Furthermore, associations were often observed with pasteurellas and bovine respiratory syncytial virus. Of these M. bovis isolates, many were resistant to several antimicrobial agents which are used in cattle practice, except to fluoroquinolones. Inasmuch the high frequency of M. bovis isolation and antibiotic resistances, it is very important to understand the pathogenicity of this bacteria in order to optimize prophylactic tools. Therefore, the study of the cytadherence of M. bovis is essential since it represents the first step of the bacterial infection. According to our experimental results, PG45 is not representative of field isolates because of its low adherence rates to various cell lines. This could be explained by the high number of subcultures of this pathogenic strain underwent since its first isolation, which sharply contrasts with other isolates. M. bovis adheres specifically to bovine bronchial epithelial cells in primary culture. Proteins such as variable surface proteins C and F are involved in this step as observed by decreased adherence rates after trypsinization of mycoplasma cells or addition of monoclonal antibodies. [less ▲]

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See detailEffet de la géométrie et de la disposition des mobiles d'agitation sur la formation de mousse en cuve agitée
Delvigne, Frank ULiege; Bruxelmane, Marc; Thonart, Philippe ULiege

in Tribune de l'Eau (La) (2003), 622(2), 65-70

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See detailDuplex ultrasound as first-line screening test for patients suspected of renal artery stenosis: prospective evaluation in high-risk group.
NCHIMI LONGANG, Alain ULiege; Biquet, J. F.; Brisbois, D. et al

in European Radiology (2003), 13(6), 1413-9

Our objective was to assess how far the progress in ultrasound devices has increased feasibility and accuracy of Duplex ultrasound (DUS) for the diagnosis of renal artery stenosis (RAS), in a population ... [more ▼]

Our objective was to assess how far the progress in ultrasound devices has increased feasibility and accuracy of Duplex ultrasound (DUS) for the diagnosis of renal artery stenosis (RAS), in a population with high prevalence of atherosclerotic renovascular lesions. Ninety-one hypertensive patients with atherosclerotic disease were prospectively evaluated by both DUS and digital subtraction angiography (DSA) of the renal arteries. Only proximal criteria (peak systolic velocity >180 mm/s or renal-to-aortic ratio >3.5) were used for the diagnosis of significant RAS (>60% narrowing). For both techniques, two readers were involved for interobserver variability study. Two hundred one arteries were demonstrated by DSA on 182 available kidneys. The prevalence of RAS among the study group was 37%. Sixteen of the 19 accessory arteries were not seen at DUS; in 8 patients, one renal artery was not seen at DUS (feasibility 91%). On the 177 arteries assessed, in comparison with DSA, DUS yielded 96, 91, and 97% mean values of accuracy, sensitivity, and specificity, respectively. Kappa for interobserver agreement was 0.95 for DUS and 0.92 for DSA. Although still unreliable for the detection of accessory arteries, DUS is in our experience an accurate and reproducible diagnostic test for RAS. [less ▲]

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See detailRisque cardiovasculaire global: HOPE fait vivre plus longtemps
Krzesinski, Jean-Marie ULiege

in Tempo Médical (2003), 247

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les ... [more ▼]

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les recommandations les plus récentes vont de plus en plus dans le sens d'une prise en charge du risque cardiovasculaire global, accordant moins d'importance à la valeur absolue de chacun des facteurs de risque; les patients présentant le plus grand risque global devant, bien entendu, être prioritairement traités. Une attitude, basée sur les résultats de quelques grandes études cliniques, dont HOPE (Heart Outcomes Prevention Evaluation). Nous vous proposons ici un rappel des résultats de cette étude remarquable, ainsi qu'un commentaire sur cette nouvelle approche préventive du risque CV, en compagnie de quelques uns des orateurs du congrès Cardio 2003. [less ▲]

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See detailA magnetic and Mossbauer spectral study of TbFe11Ti and TbFe11TiH
Piquer, C.; Hermann, Raphaël ULiege; Grandjean, François-Xavier ULiege et al

in Journal of Physics : Condensed Matter (2003), 15(43), 7395-7409

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering ... [more ▼]

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering temperature, magnetization, magnetic hyperfine fields, and isomer shifts as a result of lattice expansion. Further, the insertion of hydrogen reinforces the basal magnetic anisotropy of the terbium sublattice and, as is shown by ac susceptibility measurements and thermomagnetic analysis, the spin reorientation observed in TbFe11Ti at 338 K disappears in TbFe11TiH. The Mossbauer spectra have been analysed with a model that considers both the easy magnetization direction and the distribution of titanium atoms in the near-neighbour environment of the three crystallographically distinct iron sites. The assignment and the temperature dependencies of the hyperfine fields and isomer shifts are in complete agreement with a Wigner-Seitz cell analysis of the three iron sites in RFe11Ti and RFe11TiH, where R is a rare-earth element. A complete analysis of the quadrupole interactions in both magnetic phases and in the paramagnetic phase of TbFe11Ti supports the Mossbauer spectral analysis, and indicates that in the basal magnetic phase the iron magnetic moments are oriented along the equivalent [100] and [010] directions of the unit cell. [less ▲]

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See detailRT-PCR-ELISA for Detection of Apple stem grooving virus in Apple Trees
Marinho, Véra Lucia A.; Daniels, Julio; Kummert, Jean et al

in fitopatologia Brasileira (2003), 28(4), 374-379

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See detailTemporal variability of neurography
WANG, François-Charles ULiege; Horward, Alain

in Journal of Neurology (2003)

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See detailL’émergence d’un marché d’immobilier d’entreprise. L’exemple de la Wallonie
Merenne-Schoumaker, Bernadette ULiege

in Géocarrefour (2003), 78

In less than ten years, a business property market has emerged in Wallonia. This market first concerned offices and retail units (a sector not studied in this paper) and, more recently, semi-industrial ... [more ▼]

In less than ten years, a business property market has emerged in Wallonia. This market first concerned offices and retail units (a sector not studied in this paper) and, more recently, semi-industrial establishments. Its development is largely related to the creation of new demands in physical units, environment and accessibility, as well as in location choices, at both sub-regional and local scales. It has been favoured by the arrival of new property stakeholders from Belgium and abroad (developers, investors and property agents), as well as by public authorities (the Walloon Region and, more importantly, supra-communal, economic development agencies). The emergence of this market is related to the accentuation of territorial contrasts as property development projects usually reinforce strong area [less ▲]

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : III) Production de toxines
Van Bost, S.; Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(5, OCT-NOV), 327-342

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, enterohaemmorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains: adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This third manuscript presents the current knowledge on toxins produced by invasive strains of E. coli: endotoxins, cytotoxic necrotising factors, cytolethal distending toxins and haemolytic toxins. [less ▲]

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See detailEfficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study
van de Putte, L. B. A.; Rau, R.; Breedveld, F. C. et al

in Annals of the Rheumatic Diseases (2003), 62(12), 1168-1177

OBJECTIVES: To evaluate efficacy, dose response, safety, and tolerability of adalimumab (D2E7) in disease modifying antirheumatic drug (DMARD) refractory patients with longstanding, active rheumatoid ... [more ▼]

OBJECTIVES: To evaluate efficacy, dose response, safety, and tolerability of adalimumab (D2E7) in disease modifying antirheumatic drug (DMARD) refractory patients with longstanding, active rheumatoid arthritis (RA). METHODS: During a 12 week, double blind, placebo controlled study, 284 patients were randomly allocated to receive weekly subcutaneous injections of adalimumab 20 mg (n = 72), 40 mg (n = 70), or 80 mg (n = 72) or placebo (n = 70) without concomitant DMARDs. RESULTS: Adalimumab significantly improved the signs and symptoms of RA for all efficacy measures. ACR20 responses with adalimumab were significant at each assessment versus placebo (p</=0.01). Additionally, ACR responses with adalimumab were achieved more rapidly than with placebo, with 82/115 (71%) of the ultimate ACR20 response rate to adalimumab treatment achieved at week 2. At week 12, for adalimumab 20, 40, and 80 mg, ACR20 response rates were 50.7%, 57.1%, and 54.2%, respectively, versus 10.0% for placebo (p</=0.001 for all comparisons); ACR50 rates were 23.9%, 27.1%, and 19.4%, respectively, versus 1.4% for placebo (p</=0.001 for all comparisons); and ACR70 rates were 11.3%, 10.0%, and 8.3%, respectively, versus 0.0% for placebo (p</=0.05 for all comparisons). All adalimumab doses significantly improved all ACR core criteria at all assessments. The 40 mg and 80 mg doses provided similar benefit. Adalimumab at all doses was generally well tolerated, with only mild or moderate adverse events. Completion rates were 87% for adalimumab and 67% for placebo. CONCLUSIONS: Adalimumab given as monotreatment to patients with longstanding, severe RA refractory to traditional DMARDs produced a rapid, sustained response and was safe and well tolerated, with no dose limiting side effects. [less ▲]

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See detailHaplotype diversity of the myostatin gene among beef cattle breeds
Dunner, S.; Miranda, M. E.; Amigues, Y. et al

in Genetics, Selection, Evolution (2003), 35(1, JAN-FEB), 103-118

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were ... [more ▼]

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were identified which contribute to the high polymorphism (1 SNP every 100 bp) present in this small gene; twenty haplotypes were described and a genotyping method was set up using the Oligonucleotide Ligation Assay (OLA) method. Some haplotypes appeared to be exclusive to a particular breed; this was the case for 5 in the Charolaise (involving mutation Q204X) and 7 in the Maine-Anjou (involving mutation E226X). The relationships between the different haplotypes were studied, thus allowing to test the earlier hypothesis on the origin of muscular hypertrophy in Europe: muscular hypertrophy (namely m821 (del11)) was mainly spread in different waves from northern Europe milk purpose populations in most breeds; however, other mutations (mostly disruptive) arose in a single breed, were highly selected and have since scarcely evolved to other populations. [less ▲]

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See detailUltrasound appearance of bowel wall in Wolman's disease.
NCHIMI LONGANG, Alain ULiege; Rausin, Leon; Khamis, Jamil

in Pediatric Radiology (2003), 33(4), 284-5

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See detailLa responsabilité pénale des personnes morales : question de droit transitoire
Michiels, Olivier ULiege

in Journal du Juriste (2003), (22), 16

L'article 5 alinéa 2 du Code pénal permet de poursuivre pénalement des personnes morales. Il offre également à la personne physique identifiée, qui serait poursuvie en même temps que la personne morale ... [more ▼]

L'article 5 alinéa 2 du Code pénal permet de poursuivre pénalement des personnes morales. Il offre également à la personne physique identifiée, qui serait poursuvie en même temps que la personne morale, la possibilité de se prévaloir, si l'infraction n'a été commise ni sciemment, ni volontairement, d'une cause d'excuse absolutoire. L'article fait le point sur la question du droit transitoire applicable à ce nouveau régime. [less ▲]

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See detailIntensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al

in Blood (2003), 102(13), 4284-4289

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]

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See detailLe parcours scolaire fait toute la différence
Lafontaine, Dominique ULiege; Demeuse, Marc ULiege

in Wallonie (2003), 76

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See detailNew illumination technique for IR-video guided patch-clamp recording from neurons in slice cultures on biomembrane
Alix, Philippe ULiege; Winterer, J; Muller, W

in Journal of Neuroscience Methods (2003), 128

Slice cultures on biomembrane are the method of choice for studying Ca2 -dependent plastic changes occurring over several days to weeks. Using IR-differential interference contrast, good visualization of ... [more ▼]

Slice cultures on biomembrane are the method of choice for studying Ca2 -dependent plastic changes occurring over several days to weeks. Using IR-differential interference contrast, good visualization of neurons in biomembrane slice cultures has been achieved despite a negative optical effect of the biomembrane, but epifluorescence imaging requires removal of a Wollaston prism and the analyzer. Here, we describe a novel illumination method to overcome this problem. Using optic fiber illumination at a shallow angle from the top of the slice culture, with or without additional illumination from the bottom, we obtained good cellular resolution of neurons in biomembrane slice cultures as well as in acute slices with an infrared-video camera. With this technique, we demonstrate visually guided whole-cell patch-clamp recording of Na - and K -currents as well as combination of whole-cell recording with fluorescence imaging of hippocampal and entorhinal cortex neurons in biomembrane slice cultures. Our inexpensive method should prove very useful for studying in vitro effects of long-term manipulations on membrane currents and intracellular Ca2 -signaling. # 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailPièges de la chirurgie coelioscopique: comment faire face aux complications?
Joris, Jean ULiege; Kaba, Abdourahmane ULiege

in Praticien en Anesthésie Réanimation (Le) (2003), 7(5), 339-345

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See detailHow do paedomorphic newts cope with lake drying?
Denoël, Mathieu ULiege

in Ecography (2003), 26(4), 405-410

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic ... [more ▼]

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic habitats surrounded by hostile terrestrial environments. Nevertheless, numerous ponds inhabited by paedomorphic individuals are unpredictable and temporary. In an experimental framework, I showed that paedomorphic newts were able to metamorphose and thus survive in the absence of water. However, the mere decrease of water level or the life space do not seem to induce metamorphosis in paedomorphs. On the contrary, drying up induces almost all individuals to move on land and after that to colonize other aquatic sites located nearby. Such terrestrial migrations allow survival in drying conditions without metamorphosis as long as the distances of terrestrial migration are short. These results are consistent with the presence of paedomorphs in drying ponds and are in favor of classic optimality models predicting metamorphosis in unfavorable environments. [less ▲]

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See detailCutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision.
Claessens, Nadine; Heymans, Olivier; Arrese Estrada, Jorge ULiege et al

in American Journal of Clinical Dermatology (2003), 4(11), 799-802

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which ... [more ▼]

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which consists of various, but specific, tumors. OBJECTIVE: We report two cases of subcutaneous melanotic schwannoma localized on the trunk in two men aged 37 and 45 years. METHODS: Conventional histology and immunohistochemistry were performed. RESULTS: One melanotic schwannoma was associated with a cutaneous atypical myxoma and multiple melanocytic lesions, all being part of the Carney complex. The other case had no associated signs. In both cases, the melanotic schwannoma was completely excised and did not recur. CONCLUSION: Melanotic schwannoma is rare and curable by surgery. It must not be confused with malignant melanoma and other pigmented neoplasms. The Carney complex should be carefully ruled out. [less ▲]

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See detailDysphagia Caused by Ventricular Pseudoaneurysm
Noukoua, C. T.; NCHIMI LONGANG, Alain ULiege; Biquet, J. F. et al

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2003), 86(3, May-Jun), 168-9

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See detailClassification of Crohn's disease - Vienna and Beyond
Louis, Edouard ULiege; Belaiche, Jacques ULiege

in Inflammatory Bowel Disease Monitor (2003), 5

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See detail« ‘Soñar, recordar y vivir con eso’. Los sueños de los Záparas en la construcción del pasado, Amazonia Ecuatoriana »,
Bilhaut, Anne-Gaël ULiege

in Estudios Atacameños (2003), 26

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental ... [more ▼]

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental role in their daily life. We will see how their history is constructed by means of dream experiences, and how these are used strategically in the present. Dreams, furthermore, guarantee the cultural and ritual continuity of this group on the verge of extinction. [less ▲]

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See detailLe trésor de reliques du Neufmoustier près de Huy. Une part de Terre sainte en pays mosan
George, Philippe ULiege

in Bulletin de la Commission Royale d'Histoire (2003)

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See detailHydrodynamique et morphologie d'une bactérie filamenteuse dans un fermenteur à cuve agitée
Groslambert, Sylvie ULiege; Blacher, Silvia ULiege; Crine, Michel ULiege

in Tribune de l'Eau (La) (2003), 56(622), 58-64

Afin d'étudier l'influence de l'hydrodynamique sur une bactérie filamenteuse, Actinomadura R39, nous l'avons cultivée dans un fermenteur de laboratoire de 5 litres à cuve agitée en faisant varier les ... [more ▼]

Afin d'étudier l'influence de l'hydrodynamique sur une bactérie filamenteuse, Actinomadura R39, nous l'avons cultivée dans un fermenteur de laboratoire de 5 litres à cuve agitée en faisant varier les conditions d'agitation. Les variables sont la vitesse de rotation et le type de mobile utilisé: turbines Rushton ou Intermig. Les deux mobiles se distinguent par leur géométrie et par les schémas d'écoulement qu'ils induisent dans la cuve. L'influence de l'hydrodynamique sur Actinomadura R39 est quantifiée par l'évolution de sa morphologie. Cette dernière est estimée par analyse d'images sur des échantillons prélevés lors des cultures. Parallèlement, nous avons caractérisé l'hydrodynamique du fermenteur dans un milieu artificiel reproduisant la rhéologie des fermentations en mesurant la puissance dissipée et en effectuant des essais de traceurs. Ces derniers sont utilisés pour la modélisation du fermenteur par un modèle compartimenté et le calcul du temps de mélange. Nous avons pu ainsi mettre en relation les modifications de la morphologie et des grandeurs caractérisant les écoulements dans le fermenteur. L'existence de corrélations entre les paramètres du modèle et la morphologie a également permis une validation de la signification physique de ce modèle. [less ▲]

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See detailTandem high-dose therapy (HDT) for multiple myeloma: recombinant human erythropoietin therapy given between first and second HDT allows second peripheral blood stem cell transplantation without red blood cell transfusion.
Baron, Frédéric ULiege; Frere, Pascale ULiege; Fillet, Georges ULiege et al

in British Journal of Haematology (2003), 123(1), 103-5

We evaluated the ability of recombinant human erythropoietin (rHuEpo) therapy, given before high-dose therapy (HDT), to allow autologous peripheral blood stem cell transplantation (PBSCT) without red ... [more ▼]

We evaluated the ability of recombinant human erythropoietin (rHuEpo) therapy, given before high-dose therapy (HDT), to allow autologous peripheral blood stem cell transplantation (PBSCT) without red blood cell (RBC) transfusions. Eleven multiple myeloma patients underwent tandem HDT and autologous PBSC, receiving 500 U/kg/week rHuEpo from d 30 after initial transplant. Haemoglobin levels were 9.5 +/- 1.1 g/dl and 12.5 +/- 0.9 g/dl at the first and second transplant respectively (P < 0.001). RBC transfusions were required for 10/11 patients for the first transplant versus 1/11 for the second (P < 0.001). To conclude, a short course of rHuEpo therapy before HDT facilitates the performance of an autologous transplant without RBC transfusions. [less ▲]

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See detailEffect of rival males on the courtship of paedomorphic and metamorphic Triturus alpestris (Amphibia : Salamandridae)
Denoël, Mathieu ULiege

in Copeia (2003), 2003(3), 618-623

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and ... [more ▼]

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and salamanders is a suitable process to explore this question because it implies the coexistence of two different morphological morphs differing by the presence of gills and epigamic traits. The aim of this study was to find out whether paedomorphs and metamorphs use similar tactics to attract mates in the presence of a rival and whether there are differences in sexual activity and success between alternative morphs. Sexual interactions in triadic encounters were staged and analyzed in a standardized experimental design. The two kinds of males did not differ in terms of sexual activity, spermatophore deposition or female responsiveness. Both rival paedomorphic and metamorphic males exhibited sexual interference, but in most encounters, intruders just disturbed the courting pair. Sperm transfer success was lower in triadic encounters than in dyadic encounters. These results illustrate that intermorph breeding also occurs in the presence of competitors but that the success rate of the newts is considerably decreased in such competitive situations. Moreover, newts do not use alternative reproductive tactics depending on their status (i.e., paedomorph or metamorph). [less ▲]

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See detailFluorescent Pseudomonas mainly produce the dihydro form of pyoverdine at low specific growth rate.
Jacques, Philippe ULiege; Ongena, MARC ULiege; Bernard, F. et al

in Letters in Applied Microbiology (2003), 36(5), 259-62

AIMS: To analyse the influence of cell growth rate and iron concentration on the production of pyoverdines (PVDs) and of their reduced dihydro forms by three fluorescent Pseudomonas strains (P. putida ... [more ▼]

AIMS: To analyse the influence of cell growth rate and iron concentration on the production of pyoverdines (PVDs) and of their reduced dihydro forms by three fluorescent Pseudomonas strains (P. putida BTP16, P. fluorescens BTP7 and P. aeruginosa 7NSK2). METHODS: PVD and dihydropyoverdine (DHPVD) productions were determined by LC ESI-MS and spectrophotometry during batch and chemostat culture at different dilution rates. SIGNIFICANCE: The relatively high PVD-to-DHPVD ratio (0.57) observed in pH-controlled batch cultures suggested that a base-catalysed chemical oxidation of the dihydroform is not the prime mechanism involved in generating PVDs. Interestingly, in chemostat cultures the PVD-to-DHPVD ratio was significantly reduced at low specific growth rate. Our results suggest that the oxidation of DHPVD to PVD is catalysed by an iron-dependent enzymatic reaction rather than a chemical oxidation. [less ▲]

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See detailResource partitioning in two heterochronic populations of Greek Alpine newts, Triturus alpestris veluchiensis
Denoël, Mathieu ULiege; Schabetsberger, R.

in Acta Oecologica: International Journal of Ecology (2003), 24(1), 55-64

Current ecological models suggest that the maintenance of trophic polymorphisms is favoured by a different resource use in alternative morphs. Facultative paedomorphosis in newts is an example of ... [more ▼]

Current ecological models suggest that the maintenance of trophic polymorphisms is favoured by a different resource use in alternative morphs. Facultative paedomorphosis in newts is an example of phenotypic variation as paedomorphs retain morphological larval traits, such as gills and gill slits. The aim of this study was to find out whether heterochronic morphs occupy particular micro-habitats and focus on specific prey items. Resource partitioning was found between morphs. It concerns mainly food selection with paedomorphs preying more on plankton and less on terrestrial invertebrates than metamorphs. Some habitat specializations were also found with metamorphs being more abundant at the water surface than paedomorphs. Diel variation in habitat use of the two different morphs was minimal. Polymorphism allows Alpine newts to exploit the different resources in the lakes in order to minimize intraspecific competition, but the extent of resource partitioning depends on habitat characteristics. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved. [less ▲]

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See detailLipides, dépression et suicide
Colin, A.; Reggers, Jean ULiege; Castronovo, Vincenzo ULiege et al

in Encéphale (L') (2003), 29(1, JAN-FEB), 49-58

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 ... [more ▼]

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 fatty acids (for example : alpha-linolenic acid or alpha-LNA) and polyunsatured omega6 fatty acids (for example : linoleic acid or LA). These two classes of fatty acids are said to be essential because they cannot be synthetised by the organism and have to be taken from alimentation. The omega3 are present in linseed oil, nuts, soya beans, wheat and cold water fish whereas omega6 are present in maize, sunflower and sesame oil. Fatty acids are part of phospholipids and, consequently, of all biological membranes. The membrane fluidity, of crucial importance for its functionning, depends on its lipidic components. Phospholipids composed of chains of polyunsatured fatty acids increase the membrane fluidity because, by bending some chains, double bonds prevent them from compacting themselves perfectly. Membrane fluidity is also determined by the phospholipids/free cholesterol ratio, as cholesterol increases membrane viscosity. A diet based on a high proportion of essential polyunsatured fatty acids (fluid) would allow a higher incorporation of cholesterol (rigid) in the membranes to balance their fluidity, which would contribute to lower blood cholesterol levels. Brain membranes have a very high content in essential polyunsatured fatty acids for which they depend on alimentation. Any dietary lack of essential polyunsatured fatty acids has consequences on cerebral development, modifying the activity of enzymes of the cerebral membranes and decreasing efficiency in learning tasks. Epidemiological data - The prevalence of depression seems to increase continuously since the beginning of the century. Though different factors most probably contribute to this evolution, it has been suggested that it could be related to an evolution of alimentary patterns in the Western world, in which polyunsatured omega fatty acids contained in fish, game and vegetables have been largely replaced by polyunsatured omega6 fatty acids of cereal oils. Some epidemiological data support the hypothesis of a relation between lower depression and/or suicide rates and a higher consumption of fish. These data do not however prove a relation of causality. Cholesterol and depression - Several cohort studies (on nondepressed subjects) have assessed the relationship between plasma cholesterol and depressive symptoms with contradictory results. Though some results found a significant relationship between a decrease of total cholesterol and high scores of depression, some other did not. Studies among patients suffering from major depression signalled more constantly an association between low cholesterol and major depression. Besides, some trials showed that clinical recovery maybe associated with a significant increase of total cholesterol. Cholesterol and suicidal behaviour - The hypothesis that a low cholesterol level may represent a suicidal risk factor was discovered accidentally following a series of epidemiological studies which revealed an increase of the suicidal risk among subjects with a low cholesterol level. Though some contradictory studies do exist, this relationship has been confirmed by several subsequent cohort studies. These findings have challenged the vast public health programs aimed at promoting the decrease of cholesterol, and even suggested to suspend the administration of lipid lowering drugs. Recent clinical studies on populations treated whith lipid lowering drugs showed nevertheless a lack of significant increase of mortality, either by suicide or accident. In addition, several controlled studies among psychiatric patients revealed a decrease of the concentrations of plasma cholesterol among patients who had attempted suicide in comparison with other patients. Polyunsaturated fatty acids and depression - In major depression, all studies revealed a significant decrease of the polyunsaturated omega3 fatty acids and/or an increase of the omega6/omega3 ratio in plasma and/or in the membranes of the red cells. In addition, two studies found a higher severity of depression when the level of polyunsaturated omega fatty acids or the ratio omega3/omega6 was low. Parallel to these modifications, other biochemical perturbations have been reported in major depression, particularly an activation of the inflammatory response system, resulting in an increase of the pro-inflammatory cytokines (interleukins: IL-1beta, IL-6 and interferon gamma) and eicosanoids (among others, prostaglandin E2) in the blood and the CSF of depressed patients. These substances cause a peroxidation and, consequently a catabolism of membrane phospholipids, among others those containing polyunsaturated fatty acids. The cytokines and eicosanoids derive from polyunsaturated fatty acids and have opposite physiological functions according to their omega or omega6 precursor. Arachidonic acid (omega6) is, among others, precursor of pro-inflammatoty prostaglandin E2 (PGE2), whereas polyunsaturated W fatty acids inhibit the formation of PGE2. It has been shown that a dietary increase of polyunsaturated W fatty acids reduced strongly the production of IL-1beta, IL-2, IL-6 and TNF-alpha (tumor necrosis factor-alpha). In contrast, diets with a higher supply of linoleic acid (omega6) increased significantly the production of pro-inflammatory cytokines, like TNF-alpha. Therefore, polyunsaturated omega3 fatty acids could be associated at different levels in the pathophysiology of major depression, on the one hand through their role in the membrane fluidity which influences diverse steps of neurotransmission and, on the other hand, through their function as precursor of pro-inflammatory cytokines and eicosanoids disturbing neurotransmission. In addition, antidepressants could exhibit an immunoregulating effect by reducing the release of pro-inflammatory cytokines, by increasing the release of endogenous antagonists of pro-inflammatory cytokines like IL-10 and, finally, by acting like inhibitors of cyclo-oxygenase. Therapeutic use of fatty acids - Data available concerning the administration of supplements of DHA (docosahexanoic acid) or other polyunsaturated fatty acids omega3 are limited. In a double blind placebo-controlled study on 30 patients with bipolar disorder, the addition of polyunsaturated omega3 fatty acids was associated with a longer period of remission. Moreover, nearly all the other prognosis measures were better in the omega3 group. Very recently, a controlled trial showed the benefits of adding an omega3 fatty acid, eicosopentanoic acid, among depressed patients. After 4 weeks, six of the 10 patients receiving the fatty acid were considered as responders in comparison with only one of the ten patients receiving placebo. Conclusions Some epidemiological, experimental and clinical data favour the hypothesis that polyunsaturated fatty acids could play a role in the pathogenesis and/or the treatment of depression. More studies however are needed in order to better precise the actual implication of those biochemical factors among the various aspects of depressive illness. [less ▲]

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See detailLes protéines de choc thermique (heat shock proteins). II Les protéines de choc thermique (heat shock proteins). II. Hsp70, biomarqueur, bioprotecteur.
Wirth, Delphine; Gustin, Pascal ULiege; Drion, Pierre ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(2), 127-144

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was ... [more ▼]

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was initially discovered in Drosophila. The genes hsps were among the first eukaryotic genes to be cloned and whose regulation, which involves activation of heat shock factor (HSF), was elucidated. More recently, study of Hsp functions, particularly Hsp70, started. Their protective role, related to their molecular chaperon function, was inferred from experiments showing that Hsp70 expression, induced by a first stress, results in a cellular tolerance to second stress. Better understanding of the heat shock response had led to the development of two search fields on Hsp70 expression : (1) its use as biomarker of cellular stress and (2) the exploitation of its cytoprotective functions against various insults. This review includes historic of the research on the heat shock response, description of regulation mechanism of Hsp70 expression, and the interesting perspectives allocated to Hsp70 as biomarker and therapeutic tool. ----------- L’exposition de tout organisme à des températures élevées induit l'expression cellulaire rapide et transitoire de protéines spécifiques, les protéines de choc thermique (Hsps pour " heat shock proteins "). Cette réponse des cellules au choc thermique ou " heat shock response " a été initialement découverte chez la drosophile. Les gènes hsps furent parmi les premiers gènes eucaryotes à être clonés et utilisés comme paradigme dans l'étude des mécanismes de régulation transcriptionnelle faisant intervenir l'activation d'un ou plusieurs " heat shock factors" (HSFs). C'est plus récemment que l'étude des fonctions des Hsps, particulièrement Hsp70, a débuté. Le rôle protecteur de celle-ci, lié à sa fonction de " chaperon " protéique, a été déduit d'expériences montrant que l'induction de l'expression de Hsp70 lors d'un stress était associée au développement d'une tolérance cellulaire vis-à-vis d'un stress ultérieur. En plus d'un intérêt fondamental pour la compréhension de la "réponse au choc thermique", deux axes de recherche appliquée se sont développés visant à investiguer la possibilité d'utiliser l'expression de Hsp70 comme biomarqueur de souffrance cellulaire d'une part et, d'autre part, d'exploiter ses fonctions comme moyen de protection des cellules contre divers types d'agressions. Cette revue décrit l'historique des découvertes sur la " réponse au choc thermique ", le mécanisme régulant l'expression de Hsp70 ainsi que les perspectives intéressantes s'ouvrant à l'utilisation de l'expression de Hsp70 en tant que biomarqueur et outil thérapeutique. [less ▲]

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See detailCompte rendu de l'ouvrage de M. Lamy : L'Immaculée Conception
Delfosse, Annick ULiege

in Moyen Age (Le) (2003), 109(2), 388-389

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See detailPiracetam Inhibits The Lipid-Destabilising Effect Of The Amyloid Peptide A Beta C-Terminal Fragment
Mingeot-Leclercq, Mp.; Lins, Laurence ULiege; Bensliman, M. et al

in Biochimica et Biophysica Acta-Biomembranes (2003), 1609(1), 28-38

Amyloid peptide (Abeta) is a 40/42-residue proteolytic fragment of a precursor protein (APP), implicated in the pathogenesis of Alzheimer's disease. The hypothesis that interactions between Abeta ... [more ▼]

Amyloid peptide (Abeta) is a 40/42-residue proteolytic fragment of a precursor protein (APP), implicated in the pathogenesis of Alzheimer's disease. The hypothesis that interactions between Abeta aggregates and neuronal membranes play an important role in toxicity has gained some acceptance. Previously, we showed that the C-terminal domain (e.g. amino acids 29-42) of Abeta induces membrane permeabilisation and fusion, an effect which is related to the appearance of non-bilayer structures. Conformational studies showed that this peptide has properties similar to those of the fusion peptide of viral proteins i.e. a tilted penetration into membranes. Since piracetam interacts with lipids and has beneficial effects on several symptoms of Alzheimer's disease, we investigated in model membranes the ability of piracetam to hinder the destabilising effect of the Abeta 29-42 peptide. Using fluorescence studies and 31P and 2H NMR spectroscopy, we have shown that piracetam was able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. While the peptide induced lipid disorganisation and subsequent negative curvature at the membrane-water interface, the conformational analysis showed that piracetam, when preincubated with lipids, coats the phospholipid headgroups. Calculations suggest that this prevents appearance of the peptide-induced curvature. In addition, insertion of molecules with an inverted cone shape, like piracetam, into the outer membrane leaflet should make the formation of such structures energetically less favourable and therefore decrease the likelihood of membrane fusion. [less ▲]

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See detailCompte rendu de Reliques et châsses de la collégiale de Soignies
George, Philippe ULiege

in Revue d'Histoire Ecclésiastique (2003)

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See detailDynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period
Debier, Cathy; Pomeroy, Paddy P.; Dupont, Cédric et al

in Marine Ecology-Progress Series (2003), 247

The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber ... [more ▼]

The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber, maternal serum, milk and pup serum. Mother-pup pairs were captured regularly between birth and weaning on the Isle of May, Scotland. The PCB profiles of the different compartments of transfer consisted mainly of congeners 153, 138, 180, 187, 170 and 101, which made up 85% of the total PCB burden. Outer blubber contained higher relative concentrations (R-153) Of hepta-, octa-, and nona-chlorinated congeners (higher chlorinated congeners) than inner blubber, at both early (less than or equal to 5 d) and late (greater than or equal to 11 d) lactation. There was no change in the composition of the outer blubber layer between early and late lactation, while in the inner blubber, there was a slight increase in the R153 of higher chlorinated congeners at late lactation. In maternal serum, profiles changed towards having a higher proportion of higher chlorinated congeners as lactation progressed, but in milk, the PCB pattern stayed constant throughout lactation. Surprisingly, in pup serum profiles also changed towards higher R153 of higher chlorinated congeners at late lactation compared to early lactation, which was different to the pattern observed in milk. In all body compartments, higher proportions of higher chlorinated congeners were associated with higher concentrations of total PCBs. Maternal blubber and pup serum contained a higher R153 of higher chlorinated congeners than milk and, to a lesser extent, maternal serum. Thus biomagnification of the higher chlorinated congeners was recorded in pup serum. [less ▲]

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See detailAnalysis of soil and crop properties for precision agriculture for winter wheat
Vrindts, Els; Reyniers, Marieke; Darius, Paul et al

in Biosystems Engineering (2003), 85(2), 141-152

In a precision farming research project financed by the Belgian Ministry of Small Trade and Agriculture, the methods of precision agriculture are tested on grain fields with a view of implementation of ... [more ▼]

In a precision farming research project financed by the Belgian Ministry of Small Trade and Agriculture, the methods of precision agriculture are tested on grain fields with a view of implementation of precision agriculture methods in Belgian field agriculture. The project encompasses methods for automatic information gathering on soil and crop and analysis of this data for management of within-field variability. Automatic information capturing is combined with traditional data sources of soil sample analysis and crop observations. The measurements and part of the results on one particular field in Sauvenière are presented here. Five nitrogen management strategies were compared, but the resulting differences in nitrogen dose were small and did not lead to significantly different yield results. The yield results were correlated to topography-related variations in soil texture and chemical components and to crop reflectance measurements in May. [less ▲]

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See detailThe impact of reimbursement criteria on the appropriateness of 'statin' prescribing.
Autier, Philippe; Creplet, Jean; Vansant, Greet et al

in European Journal of Cardiovascular Prevention & Rehabilitation (2003), 10(6), 456-62

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated ... [more ▼]

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated the possible impact of these regulations on characteristics of Belgian patients receiving a lipid-lowering drug. DESIGN: From 1998 to 2000, standard questionnaires on coronary risk factors and treatments with lipid-lowering drugs were completed by 301 GPs sampled at random in the 11 Belgian Provinces. Questionnaires had to be completed for 18 consecutive patients 35 years old or more attending GPs' practices, irrespective of the underlying motive for attendance. RESULTS: Of the 5511 patients included in the study, 1519 (28%) had established coronary disease or diabetes mellitus, or > or = 2 non-cholesterol coronary risk factors. Most (70%) of these patients were not treated with a lipid-lowering drug. Only 22% of patients with established coronary disease, 10% of patients with diabetes mellitus and 9% of patients with > or = 2 coronary risk factors were treated with a statin. Fifty-nine percent of fibrate users and 50% of statin users had a pre-treatment cholesterol level above 250 mg/dl, but had no or only one non-cholesterol coronary risk factor. CONCLUSIONS: In Belgium, the majority of patients at higher risk of coronary event do not benefit from lipid-lowering drugs, particularly the statins. In contrast, one of two statin users and three of five fibrate users should probably not receive the drug prescribed. Regulation based on blood cholesterol level encourages the overlooking of other risk factors relevant for selecting patients having the greatest chance to benefit from statin treatment. [less ▲]

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See detailDeep infection by Trichophyton rubrum in an immunocompromised patient.
Nir-Paz, Ran; Elinav, Hila; Pierard, Gérald ULiege et al

in Journal of Clinical Microbiology (2003), 41(11), 5298-301

Dermatophytes are common pathogens of skin but rarely cause invasive disease. We present a case of deep infection by Trichophyton rubrum in an immunocompromised patient. T. rubrum was identified by ... [more ▼]

Dermatophytes are common pathogens of skin but rarely cause invasive disease. We present a case of deep infection by Trichophyton rubrum in an immunocompromised patient. T. rubrum was identified by morphological characteristics and confirmed by PCR. Invasiveness was apparent by histopathology and immunohistochemistry. The patient was treated successfully with itraconazole. [less ▲]

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See detailComment on 'Quantum inversion of cold atoms in a microcavity: spatial dependence'
Bastin, Thierry ULiege; Martin, John ULiege

in Journal of Physics : B Atomic Molecular & Optical Physics (2003), 36

In a recent work, Abdel-Aty and Obada (2002 J. Phys. B: At. Mol. Opt. Phys. 35 807-13) analysed the quantum inversion of cold atoms in a microcavity, the motion of the atoms being described quantum ... [more ▼]

In a recent work, Abdel-Aty and Obada (2002 J. Phys. B: At. Mol. Opt. Phys. 35 807-13) analysed the quantum inversion of cold atoms in a microcavity, the motion of the atoms being described quantum mechanically. Two-level atoms were assumed to interact with a single mode of the cavity, and the off-resonance case was considered (namely the atomic transition frequency is detuned from the single-mode cavity frequency). We demonstrate in this paper that this case is incorrectly treated by these authors, and we therefore question their conclusions. [less ▲]

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See detailProcédure de liquidation-partage
Leleu, Yves-Henri ULiege

in Revue de Droit de l'ULB (2003)

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See detailLe positionnement multidimensionnel : principes et applications
Palm, Rodolphe ULiege

in Notes de Statistique et d'Informatique (2003), (1), 1-32

This note describes some multidimensional scaling methods for two-way, one-mode tables and for three-way, two-mode tables. The methods are illustrated by an example processed by PROC MDS of SAS software.

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See detailFirst-principles calculation of the electronic, dielectric, and dynamical properties of CaF2
Verstraete, Matthieu ULiege; Gonze, Xavier

in Physical Review. B : Condensed Matter (2003), 68

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See detailComparaison empirique des estimateurs des taux d'erreur en analyse discriminante
Glele Kakai, R.; Piraux, F.; Fonton, N. H. et al

in Revue de Statistique Appliquée (2003), LI(3), 61-74

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi ... [more ▼]

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi-square and beta) have been considered. Estimators eOS (for actual and expected error rate) and eB (for optimal error rate) are the best, except for distributions very different from normal distributions. The e632 estimator is the best non parametric estimator. This estimator is better than parmetric estimators for distributions very different from normal distributions. [less ▲]

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See detailRevue de l'épidémiologie de la maladie de Crohn en Europe
Piront, Patricia ULiege; Belaiche, Jacques ULiege; Louis, Edouard ULiege

in Acta Endoscopica (2003), 33

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See detailEstado, mercado y diversidad cultural
Martiniello, Marco ULiege

in Revista de Occidente (Madrid, Spain : 1923) (2003), 268

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See detailLoss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice
Robaye, B.; Ghanem, E.; Wilkin, F. et al

in Molecular Pharmacology (2003), 63(4), 777-783

The P2Y4 receptor is responsive to UTP in human and to ATP and UTP in rodents. With the aim of identifying its pharmacotherapeutic interest, we generated P2Y4-null mice by a classic gene targeting method ... [more ▼]

The P2Y4 receptor is responsive to UTP in human and to ATP and UTP in rodents. With the aim of identifying its pharmacotherapeutic interest, we generated P2Y4-null mice by a classic gene targeting method. The proportion of genotypes was consistent with X-linked Mendelian transmission. Gene inactivation was checked by the complete disappearance of P2Y4 receptor mRNA from liver, stomach, and intestine. The P2Y4-null mice had a grossly normal behavior, growth, and reproduction. Chloride secretion by the jejunal epithelium was assessed in Ussing chambers by the measurement of the short circuit current in the presence of phlorizin. We show here that the UTP- and ATPinduced chloride secretory responses observed in wild-type mice are abolished in P2Y4-null mice. This is the first clearcut demonstration of a biological role of the P2Y4 receptor [less ▲]

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See detailAb initio study of MoS2 nanotube bundles
Verstraete, Matthieu ULiege; Charlier, Jean-Christophe

in Physical Review. B : Condensed Matter (2003), 68

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See detailA 3-D Magnetic Vector Potential Formulation Taking Eddy Currents in Lamination Stacks Into Account
Dular, Patrick ULiege; Gyselinck, J.; Geuzaine, Christophe ULiege et al

in IEEE Transactions on Magnetics (2003), 39(3), 1424--1427

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See detailInterprétation géométrique de la régression
Iemma, A. F.; Palm, Rodolphe ULiege

in Notes de Statistique et d'Informatique (2003), (2), 1-28

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See detailRole of catalase in ethanol-induced conditioned taste aversion : a study with 3-amino-1,2,4-triazole
Quertemont, Etienne ULiege; Escarabajal, M. Dolores; De Witte, Philippe

in Drug and Alcohol Dependence (2003), 70(1), 77-83

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain ... [more ▼]

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain metabolism of ethanol by the enzyme catalase. Therefore, the inhibition of catalase by 3-amino-1,2,4-triazole (aminotriazole) may help to clarify the involvement of acetaldehyde in ethanol's hedonic effects. In the present study, multiple doses of both ethanol and aminotriazole were used to investigate the effects of catalase inhibition on ethanol-induced conditioned taste aversion (CTA). A separate microdialysis experiment investigated the effects of aminotriazole pretreatment on the time course of brain ethanol concentrations. Ethanol induced a dose-dependent CTA with a maximal effect after conditioning with 2.0 g/kg ethanol. Aminotriazole pretreatments dose-dependently potentiated the CTA induced by 1.0 g/kg ethanol. However, aminotriazole pretreatments did not alter the CTA induced by higher ethanol doses (1.5 and 2.0 g/kg) probably because a maximal aversion for saccharin was already obtained without aminotriazole. The results of the microdialysis experiment confirmed that the effects of aminotriazole cannot be attributed to local alterations of brain ethanol levels. The present study argues against a role for brain acetaldehyde in ethanol's aversive effects but in favor of its involvement in ethanol rewarding properties. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailIndo-iranien *aruna
Swennen, Philippe ULiege

in Journal Asiatique (2003), 291

In sanskrit, aruna- means "red, pink". In Avestan, occidental scholars translate auruna by "wild". Nothing explains this paradox between two words whose etymological equivalence is obvious. A precise ... [more ▼]

In sanskrit, aruna- means "red, pink". In Avestan, occidental scholars translate auruna by "wild". Nothing explains this paradox between two words whose etymological equivalence is obvious. A precise reading of the Rig-Vedic stanzas shows that the feminine form of this adjective always qualifies the Dawn. This systematic use modified the meaning of the adjective. Beyond its chromatic value, it indicates in the Rigvedic poetries the intermediate time linking day and night. [less ▲]

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See detailLifting, Superadditivity, Mixed Integer Rounding and Single Node Flow Sets Revisited
Louveaux, Quentin ULiege; Wolsey, Laurence A.

in 4OR : Quarterly Journal of the Belgian, French and Italian Operations Research Societies (2003), 1

In this survey we attempt to give a unified presentation of a variety of results on the lifting of valid inequalities, as well as a standard procedure combining mixed integer rounding with lifting for the ... [more ▼]

In this survey we attempt to give a unified presentation of a variety of results on the lifting of valid inequalities, as well as a standard procedure combining mixed integer rounding with lifting for the development of strong valid inequalities for knapsack and single node flow sets. Our hope is that the latter can be used in practice to generate cutting planes for mixed integer programs. The survey contains essentially two parts. In the first we present lifting in a very general way, empha- sizing superadditive lifting which allows one to lift simultaneously different sets of variables. In the second, our procedure for generating strong valid inequalities consists of reduction to a knapsack set with a single continuous variable, construc- tion of a mixed integer rounding inequality, and superadditive lifting. It is applied to several generalizations of the 0-1 single node flow set. [less ▲]

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See detailImmigrants and National Identity in Europe - A. Triandafyllidou
Martiniello, Marco ULiege

in Nations & Nationalism (2003), 9(1), 165-166

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See detailL'engagement dans la lecture chez les jeunes de 15 ans. Résultats de PISA 2000
Lafontaine, Dominique ULiege

in Caractères (2003), 13

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See detailDiagnosis and monitoring of pregnancy in sheep: reality and perspectives
El Amiri, Bouchra; Karen, Aly; Cognié, Yves et al

in Productions Animales (2003), 16(2), 79-90

The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non ... [more ▼]

The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non-pregnant ewes, and the possibility to determine fetal numbers are carefully analysed. The progesterone assay is accurate as early as day 17th after fecundation; but the fertilization day must be precisely known. The pregnancy specific or associated glycoproteins (PSPB/PAG) assay is highly sensitive and specific at day 22 in blood and at day 32 in milk samples. However, this assay does not allow to predict the fetal number. The ultrasonography B-mode used on 30 days of gestation gives very good or excellent performance in terms of sensitivity and specificity depending on the practitioner. The method is also able to predict the real time fetal number. [less ▲]

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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULiege; Balsat, Alain; Dujardin, Marco et al

Scientific journal (2003)

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See detailFunctional neuroimaging of auditory processing
Laureys, Steven ULiege; Salmon, Eric ULiege; Goldman, Serge et al

in Acta Oto-Rhino-Laryngologica Belgica (2003), 57(4), 267-273

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm ... [more ▼]

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm the spatial distribution of brain activation in temporal areas for the processing of simple acoustic stimuli. Brain activity is much more complex for words, and different networks can be recruited when phonological, lexical and semantic levels of processing are engaged. [less ▲]

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See detailLack of agreement on fragmentation metrics blurs correspondence between fragmentation experiments and predicted effects.
Bogaert, Jan ULiege

in Conservation Ecology : A Peer-reviewed Journal of Integrative Science and Fundamental Policy Research (2003), 7(1),

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See detailLe développement de la filière "Poulet d'Ardenne" en Région Wallonne
Leroy, Pascal ULiege

in Troupeaux et cultures des tropiques (2003), 2

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