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See detailLong-Term Protection Against Bovine Leukaemia Virus Replication In Cattle And Sheep
Kerkhofs, P.; GATOT, Jean-Stéphane ULg; Knapen, K. et al

in Journal of General Virology (2000), 81

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See detailInfo-congres. Recherche en diabetologie: rayonnement europeen de l'Ecole de Liege.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(10), 960-7

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See detailLe virus de la varicelle et du zona dans le système nerveux : retraite silencieuse ou guérilla permanente ?
Rentier, Bernard ULg; Sadzot-Delvaux, Catherine ULg

in Virologie (2000), 4(3), 207-216

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features : chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological ... [more ▼]

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features : chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological aspects of these diseases such as complications of chicken pox, viral latency in sensory gan-glia and reactivation as shingles with concurrent and at times subsequent prolonged pain, are the sequels of the invasion of the peripheral nervous system during primary infection. Prevention is achieved by vaccination with a live attenuated virus strain and therapy calls for specific antiviral agents. In many respects, VZV behaves differently from close relatives. In particular, viral latency in the nervous system is quite different from that of other Herpesviri-dae. The recent discovery of the expression and accumulation of some viral regulatory proteins during latency, although VZV latency had always been considered silent, as well as the demonstration that these proteins are immu-nogenic are opening new avenues to investigate the mechanisms of VZV latency and the immune control of VZV reactivation. [less ▲]

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See detailSynthesis and evaluation of new RuCl2(p-cymene)(ER2R') and (eta(1):eta(6)-phosphinoarene)RuCl2 complexes as ring-opening metathesis polymerization catalysts
Jan, Dominique; Delaude, Lionel ULg; Simal, François et al

in Journal of Organometallic Chemistry (2000), 606(1), 55-64

New RuCl2(p-cymene)(ER2R') complexes (E = P, As, Sb; R, R' = H, alkyl, arylalkyl) have been synthesized and used as catalyst precursors for the ring-opening metathesis polymerization (ROMP) of cyclooctene ... [more ▼]

New RuCl2(p-cymene)(ER2R') complexes (E = P, As, Sb; R, R' = H, alkyl, arylalkyl) have been synthesized and used as catalyst precursors for the ring-opening metathesis polymerization (ROMP) of cyclooctene, cyclopentene, and norbornene. When ER2R' was a phosphinoarene, the p-cymene ligand could be displaced upon heating and tethered (eta(1):eta(6)-phosphinoarene)RuCl2 complexes were obtained. Simple thermogravimetric analysis (TGA) of the complexes provided clear-cut indication on their potential catalytic activity in ROMP. (C) 2000 Elsevier Science S.A. All rights reserved. [less ▲]

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See detailDe la medecine factuelle aux recommandations therapeutiques. Epilogue.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (2000), 55(5), 476-7

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See detailLa compréhension des opérations additives et soustractives au travers de la résolution de problèmes arithmétiques : présentation des axes directeurs d'une thèse de doctorat en cours de préparation
Fagnant, Annick ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 117-132

Cette recherche fait l'objet d'une thèse de doctorat, présentée par l'auteur du présent article dans le cadre d'un mandat d'aspirant au F.N.R.S. Le projet est encadré par une comité de thèse constitué de ... [more ▼]

Cette recherche fait l'objet d'une thèse de doctorat, présentée par l'auteur du présent article dans le cadre d'un mandat d'aspirant au F.N.R.S. Le projet est encadré par une comité de thèse constitué de Marcel Crahay (directeur de thèse, ULg), de Jacqueline Beckers (ULg) et de Lieven Verschaffel (KUL). A l'heure actuelle, l'état d'avancement des travaux ne permet pas encore de présenter les résultats des investigations. Le présent article vise à donner un aperçu des différents axes sur lesquels porte l'étude. [less ▲]

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See detailSpondylolyse bilatérale: intérêt de la tomoscintigraphie osseuse.
Blocklet, Didier; Seret, Alain ULg; Schoutens, André

in Revue Médicale de Bruxelles (2000), 21

Clinical case.

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See detailAffections musculaires et intolérance à l'effort. 2- Traitement
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

The muscular condition, rhabdomyolysis, may cause exercise intole¬rance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical ... [more ▼]

The muscular condition, rhabdomyolysis, may cause exercise intole¬rance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical diagnosis (is the horse suffering from rhabdomyolysis or not ?) and the aetiology (what is/are the cause(s) of the condition ?) and also to provide an effective treatment [less ▲]

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See detailEffects Of Multinutrient Blocks And Polyethylene Glycol 4000 Supplies On Intake And Digestion By Sheep Fed Acacia Cyanophylla Lindl. Foliage-Based Diets
Moujahed, Nizar; Kayouli, Chedly; Thewis, André ULg et al

in Animal Feed Science & Technology (2000), 88(3-4), 219-238

The effect of multinutrient block supply and polyethylene glycol 4000 (PEG) on intake, digestion and rumen fermentation was studied in sheep fed with air-dried Acacia cyanophylla foliage (acacia)-based ... [more ▼]

The effect of multinutrient block supply and polyethylene glycol 4000 (PEG) on intake, digestion and rumen fermentation was studied in sheep fed with air-dried Acacia cyanophylla foliage (acacia)-based diet. In Experiment I, six Noire de Thibar breed sheep (BW 46 kg) were used in double 3 3 Latin square design. All diets included about 360 g of dry matter (DM) of oat±vetch hay and acacia ad libitum. Diet D0 was without a block supplement. Diet D1 included a urea± molasses±mineral block (B1). While D2 included another type of block (B2) that differed from B1 essentially by adding polyethylene glycol 4000. Each experimental period lasted 33 days (21 days for adaptation and two periods of 5 days for measurement separated by 2 days for rest). Feed intake, apparent digestibility of organic matter (OM), crude protein (CP) and crude ®bre (CF) and retained nitrogen (Nr) were measured by total faecal collection. In Experiment II, four Noire de Thibar sheep (BW 53 kg) ®tted with rumen cannulae were fed sequentially D0, D1 and D2, respectively, to 90% of intake levels as measured in Experiment I on metabolic weight (MW) base. Fermentation parameters in rumen liquid (pH, NH3-N, volatile fatty acid (VFA)) were measured at 0, 2, 5, 8, 10, 13, 16 and 21 h after the morning meal. Protozoal number and composition in rumen ¯uid were determined at 2 h sampling time. Solid digesta kinetics through the rumen was measured using chromium (Cr) mordanced acacia. The DM and CP degradation of acacia was determined using the nylon bag technique. Acacia had a relatively high content of condensed tannins (41 g kgÿ1 of DM) and acid detergent lignin (176 g kgÿ1 of DM). B1 and B2 were high in CP (381 and 369 g kgÿ1 of DM, respectively) compared to acacia (127 g kgÿ1 of DM, 20% bound to ®bre) and hay (75 g kgÿ1 of DM). The two kinds of blocks improved similarly (P < 0:001) acacia DM intake by 195 g. Block 1 increased (P < 0:001) only diet CP digestibility and Nr. Block 2 increased (P < 0:05) by a low extent DM and OM digestibility compared to D1, and remarkably (P < 0:001) CP digestibility and Nr compared to D0 and D1. Block supplies considerably increased water intake. Both B1 and B2 increased (P < 0:001) NH3-N and VFA concentrations in the rumen liquid with a positive speci®c effect of B2 (PEG). VFA molar proportion was signi®cantly modi®ed by B1 and B2. B1 and B2 decreased acetate proportion and increased propionate and butyrate proportions as compared to D0 (P < 0:001). Protozoal number in rumen ¯uid was increased signi®cantly by B1 and B2 (P < 0:001). PEG-containing block (B2) increased protozoal number as compared to B1. Both B1 and B2 increased (P < 0:001) solid out¯ow rate, with a speci®c increasing effect of B2 (D2) when compared to B1 (D1). Blocks supply did not modify in situ DM degradability of acacia, but B2 improved (P < 0:05) effective degradability of CP when compared to D0 and D1 which were similar. It is concluded that both B1 and B2 improved the nutritive value of acacia-based diet. A further positive effect was noted in D2 (PEG), especially for N metabolism. [less ▲]

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See detailAn automata-theoretic approach to branching-time model checking
Kupferman, Orna; Vardi, Moshe Y; Wolper, Pierre ULg

in Journal of the ACM (2000), 47(2), 312-360

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this ... [more ▼]

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this verification method. On the other hand, for branching temporal logic, automate-theoretic techniques have long been thought to introduce an exponential penalty, making them essentially useless for model-checking. Recently, Bernholtz and Grumberg [1993] have shown that this exponential penalty can be avoided, though they did not match the linear complexity of non-automata-theoretic algorithms. In this paper, we show that alternating tree automata are the key to a comprehensive automata-theoretic framework for branching temporal logics. Not only can they be used to obtain optimal decision procedures, as was shown by Muller ct al., but, as we show here, they also make it possible to derive optimal model-checking algorithms. Moreover, the simple combinatorial structure that emerges from the automata-theoretic approach opens up new possibilities for the implementation of branching-time model checking, and has enabled us to derive improved space complexity bounds for this long-standing problem. [less ▲]

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See detailPeut-on aider Rosetta sans assassiner Mozart ?
Crahay, Marcel ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 196-199

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See detailPET scanning and neuronal loss in acute vegetative state
Laureys, Steven ULg; Faymonville, Marie ULg; Moonen, Gustave ULg et al

in Lancet (2000), 355(9217), 1825-1826

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See detailMonitoring des animaux vivants : exemple d’un échantillonnage pour la détection des PCBs et des dioxines chez les bovins de boucherie en Belgique
Saegerman, Claude ULg; Boelaert, F.; Van Vlanderen, I. et al

in Epidémiologie et Santé Animale (2000), 38

In February 1999, a poisoning episode broke out in several industrial poultry farms in Belgium. The source of this contamination was found to be a stock of recycled fat that had been delivered by a firm ... [more ▼]

In February 1999, a poisoning episode broke out in several industrial poultry farms in Belgium. The source of this contamination was found to be a stock of recycled fat that had been delivered by a firm to several compound feed producers, between 19 and 31 January 1999. A very good correlation was observed between dioxins (PCDFs and PCDDs) and PCBs. Consequently a contamination mainly by PCBs was hypothesized. This finding made it possible to detect contaminated animals and animal products by dosage of the PCBs, more specifically by the 7 congeners with numbers 28, 52, 101, 118, 138, 153 and 180. The advantages of the dosage of PCBs compared to dioxins were its rapid test protocol and the fact that a larger number of laboratories could participate. In the cattle sector, 409 herds (0,81 p. cent) were submitted to the risk of feed contamination. The methodology used to detect a PCBs/dioxins contamination in the Belgian cattle population that was not submitted to the risk, is presented. This population is directly or indirectly destined for human consumption. It consisted in the systematic sampling of all calve fattening stations and all lots of exported bovines, and in the random sampling of slaughter cattle. This methodology is compared to the approach described in directive 96/23/CE. [less ▲]

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See detailQuando il tempo è sospeso: individuo e famiglia nell’anoressia mentale
D'Amore, Salvatore ULg

in Ecologia della Mente (2000), 1

Discusses anorexia nervosa as a complex syndrome in which sociocultural, familial, and individual components are interconnected. Based on their own work with anorexic patients and their families, the ... [more ▼]

Discusses anorexia nervosa as a complex syndrome in which sociocultural, familial, and individual components are interconnected. Based on their own work with anorexic patients and their families, the present authors examine the familial aspects of anorexia at an interactional level and a mythical level. The importance of a 3-generational perspective on anorexia is emphasized. The case study of a 17-yr-old female student with bulimic anorexia is discussed with regard to family dynamics and myths and the sculpting of the present and the future. [less ▲]

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See detailRestoration of thalamocortical connectivity after recovery from persistent vegetative state
Laureys, Steven ULg; Faymonville, Marie-Elisabeth ULg; Luxen, André ULg et al

in Lancet (2000), 355(9217), 1790-1791

Moreover, the performance on these factors is correlated to different anterior and posterior

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See detailEvaluating risk in unstable angina: role of pharmacological stress echocardiography.
Pierard, Luc ULg

in European heart journal (2000), 21(13), 1041-3

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See detailNeospora caninum, un nouvel agent abortif chez les bovins
Losson, Bertrand ULg; Bourdoiseau, G.

in Bulletin des Groupements Techniques Vétérinaires (2000), 7

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See detailThe Efficacy of Two Vaccination Schemes against Experimental Infection with a Virulent Amyxomatous or a Virulent Nodular Myxoma Virus Strain
Marlier, Didier ULg; Mainil, Jacques ULg; Boucraut-Baralon, C. et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 115-22

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An ... [more ▼]

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An experiment was designed to compare two vaccination schemes for their ability to protect rabbits against challenge with either a virulent amyxomatous MV strain or a virulent nodular MV strain. Apart from a difference in the cutaneous expression of the disease, the two challenge strains resembled each other in respect of mortality rate, naso-conjunctival shedding of virus, and tissue infection. Vaccination with SFV alone failed to prevent clinical signs, naso-conjunctival shedding or tissue infection. Vaccination with SFV followed by a booster inoculation with SG33 protected rabbits against the development of clinical signs and significantly reduced both viral shedding in naso-conjunctival exudates and viral infection of eyelids, lungs and testes; virus was, however, isolated from testes of some surviving animals. [less ▲]

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See detailStudy of the Virulence of Five Strains of Amyxomatous Myxoma Virus in Crossbred New Zealand White/Californian Conventional Rabbits, with Evidence of Long-Term Testicular Infection in Recovered Animals
Marlier, Didier ULg; Mainil, Jacques ULg; Sulon, Joseph ULg et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 101-13

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by ... [more ▼]

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by inoculation of five groups of 10 crossbred New Zealand White/Californian conventional rabbits. A much more acute myxomatosis syndrome was produced in conventional rabbits than that reproduced previously in SPF animals. However, the main clinical signs were of the respiratory type. The MV strains MYX 254/95 and 801 appeared very virulent, killing all the inoculated animals. The strains MYX 217/95, MYX 555/94 and Saint Benoist were somewhat attenuated, killing only seven, six and six rabbits, respectively. Extensive lung lesions due to supervening bacterial infections were observed in 36 of the 39 rabbits that died. Lethality was found to be a better estimate of virulence than mean survival time. By 98 days after viral inoculation, all the surviving animals had completely recovered. At that time, they were immunosuppressed by treatment with adrenocorticotrophic hormone (ACTH) for 10 days to determine whether they still harboured the virus. After the ACTH treatment, eight of the 11 surviving rabbits showed clinical signs that resembled amyxomatous myxomatosis. All the virological examinations performed on naso-conjunctival exudate, on mononuclear cells, on eyelids and on ovaries remained negative but infectious virus was isolated from the testes of three of six surviving male rabbits. [less ▲]

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See detailLes recommandations du Belgian Lipid Club pour le diagnostic et le traitement des hyperlipidemies: resume pour le praticien.
Ducobu, J.; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(5), 360-6

The present paper summarizes the last recommendations of the Belgian Lipid Club for the diagnosis and treatment of hyperlipidaemias which were published in 1999. These guidelines are in agreement with the ... [more ▼]

The present paper summarizes the last recommendations of the Belgian Lipid Club for the diagnosis and treatment of hyperlipidaemias which were published in 1999. These guidelines are in agreement with the "Recommendations of the second Task Force of European and other societies on Coronary Protection", published in 1998. We will briefly describe the evidence supporting the treatment of dyslipidaemias, especially hypercholesterolaemia, to improve coronary prognosis of at high risk subjects as well as the general strategies, lipid objectives and therapeutic means, in a practical way for the clinician. [less ▲]

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See detailQuoi de neuf dans le domaine de l'obesite?
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(7), 756-9

We will briefly comment on some interesting topics presented at the 10th European Congress on Obesity (ECO, Antwerp, Belgium, 24-27 May 2000). Special attention has been focused upon: 1) the multi ... [more ▼]

We will briefly comment on some interesting topics presented at the 10th European Congress on Obesity (ECO, Antwerp, Belgium, 24-27 May 2000). Special attention has been focused upon: 1) the multi-endocrine function of the adipocyte cell; 2) the role of gene-environment interactions; 3) the regulatory mechanisms of energy balance; 4) the neuroendocrine hypothesis for the development of visceral adiposity; 5) the numerous complications associated with obesity, more particularly type 2 diabetes; and, finally, 6) obesity prevention, especially in childhood, and new pharmacological perspectives for the treatment of obesity. [less ▲]

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See detailLe médecin généraliste face à l'urgence dentaire.
Dabée, Jean-Claude ULg; Geerts, Sabine ULg; Charpentier, Joseph ULg

in Revue Médicale de Liège (2000), 55(12), 1022-7

Counselling and drug prescription are the only means for the phycisian to manage dental emergencies. Among these, some are infection related: pulpitis, apical and periodontal abscesses, acute necrotizing ... [more ▼]

Counselling and drug prescription are the only means for the phycisian to manage dental emergencies. Among these, some are infection related: pulpitis, apical and periodontal abscesses, acute necrotizing ulcerative gingivitis and alveolitis. Urgent medical treatment includes antibiotics, mouth rinses and analgesics except for pulpitis (pain caused by thermal stimuli) for which analgesics alone are prescribed. Infection non related dental emergencies are: hemorrhage for which the best treatment is compression; trauma, mainly dental avulsion for which reimplantation must be done as soon as possible; acute TMD such as open lock which can be reduced by the Nelaton handling. [less ▲]

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See detailLes brulis, un outil de gestion de la faune en region Afrique inter-tropicale.
Cornelis, D.; Lungren, C.; Ouedraogo, Mohamar moussa ULg et al

in Parcs & Réserves (2000), 55(3-4),

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See detailESR associated with spin-labelling methods into the study of photosensitization in liposomal solutions
Hoebeke, Maryse ULg

in Bulletin de la Société Royale des Sciences de Liège (2000)

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See detailLa pseudogestation chez la chèvre, facteur d'infertilité
Zarrouk, Anissa; Drion, Pierre ULg; Beckers, Jean-François ULg

in Annales de Médecine Vétérinaire (2000), 144

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See detailEvidence of nutriceutical effectiveness in the treatment of osteoarthritis
Reginster, Jean-Yves ULg; Gillot, Vincent; Bruyère, Olivier ULg et al

in Current Rheumatology Reports (2000), 2(6), 472-477

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See detailIdentification et caractérisation partielle d'un gène de Fasciola hepatica d'intérêt diagnostique
Bossaert, K.; Martin-Alonzo, J. M.; Ruiz de Eguino, A. D. et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailCattle neosporosis in Belgium : a case-control study in dairy and beef cattle
De Meerscham, F.; Focant, C.; Boreux, R. et al

in International Journal for Parasitology (2000)

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See detailThe use of conducting polymers as cathodes for the electrochemical deposition of magnetic transition metal/rare alloys
Martinot, Lucien; Leroy, Delphine ULg; Zhan, H. et al

in Journal of Materials Chemistry (2000), 10(3), 729-735

We report the electrodeposition of Cu and Ni in aqueous solutions together with the deposition of lanthanides (Gd, Sm, Dy, Tb) and amorphous magnetic alloys of lanthanides with transition metals (Fe, Co ... [more ▼]

We report the electrodeposition of Cu and Ni in aqueous solutions together with the deposition of lanthanides (Gd, Sm, Dy, Tb) and amorphous magnetic alloys of lanthanides with transition metals (Fe, Co) onto various polymer cathodes in formamide solutions. We used conducting polymers (polypyrrole, PPy; polyethylenedioxythiophene, PEDOT) sprayed on different substrates and in addition composite materials based on carbon black (CB) mixed either with polyethylene (PE) or with polycarbonate (PC). In the latter case, the conducting material is easily shaped out in various forms. When deposited on some of these substrates, the alloys appear as an interesting material for magneto-optic recording. The electrochemical process was used for the preparation of Gd/Co and Dy/Fe alloys for which the measured coercitive fields ranged from 250–300 Oe (Dy/Fe) to about 350 Oe (Gd/Fe). We demonstrated also the feasibility of an additional electrografting of a transparent protective layer of polyacrylonitrile (PAN) in order to avoid the corrosion of the alloys by the atmosphere. [less ▲]

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See detailBegian guidelines concerning drug induced alteration of coagulation and central neuraxial anesthesia
Brichant, Jean-François ULg; De Kock, Marc; De Mey, J. C. et al

in Acta Anaesthesiologica Belgica (2000), 51

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See detailNature et qualités de spatiocartes
Donnay, Jean-Paul ULg

in Bulletin de la Société Géographique de Liège (2000), 38

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See detailActualites therapeutiques 2000.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 852-61

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be emphasized. [less ▲]

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See detailThe effect of pressure on DSr (plag/melt) and DCr (opx/melt): implications for anorthosite petrogenesis
Vander Auwera, Jacqueline ULg; Longhi, John; Duchesne, Jean-Clair ULg

in Earth and Planetary Science Letters (2000), 178

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See detailDeletion Analogues Of Transportan
Soomets, U.; Lindgren, M.; Gallet, X. et al

in Biochimica et Biophysica Acta-Biomembranes (2000), 1467(1), 165-76

Several shorter analogues of the cell penetrating peptide, transportan, have been synthesized in order to define the regions of the sequence, which are responsible for the membrane translocation property ... [more ▼]

Several shorter analogues of the cell penetrating peptide, transportan, have been synthesized in order to define the regions of the sequence, which are responsible for the membrane translocation property of the peptide. Penetration of the peptides into Bowes melanoma cells and the influence on GTPase activity in Rin m5F cellular membranes have been tested. The experimental data on cell penetration have been compared with molecular modeling of insertion of peptides into biological membranes. Omission of six amino acids from the N-terminus did not significantly impair the cell penetration of the peptide while deletions at the C-terminus or in the middle of the transportan sequence decreased or abolished the cellular uptake. Most transportan analogues exert an inhibitory effect on GTPase activity. Molecular modeling shows that insertion of the transportan analogues into the membrane differs for different peptides. Probably the length of the peptide as well as the location of aromatic and positively charged residues have major impact on the orientation of peptides in the membranes and thereby influence the cellular penetration. In summary, we have designed and characterized several novel short transportan analogues with similar cellular translocation properties to the parent peptide, but with reduced undesired cellular activity. [less ▲]

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See detailSimulated And Measured Coefficients Of Variation For The Spray Distribution Under A Static Spray Boom
Debouche, Charles ULg; Huyghebaert, B.; Mostade, O.

in Journal of Agricultural Engineering Research (2000), 76(4), 381-388

The spray pattern characteristics of a number of different series of flat fan nozzles were investigated in two ways. The first method was to measure the distribution by means of a classic patternator with ... [more ▼]

The spray pattern characteristics of a number of different series of flat fan nozzles were investigated in two ways. The first method was to measure the distribution by means of a classic patternator with collecting cylinders. The second method consisted of numerical simulation of the distribution, by combining the real distributions of a number of nozzles. The real distribution was measured on a classic patternator for each nozzle separately. The numerical simulation is computerized and automated. This system allows both time and labour gains, and permits multiple trials with the same series of nozzles. Numerical simulation results are compared with spray distributions obtained on the patternator. The sprayed volumes of liquid were found to be significantly different from the simulated ones (level of significance 95%). However, the coefficient of variation characterizing the homogeneity of the spread volumes can be calculated using simulated volumes. This can be done once an empirical linear relation is established between the coefficients of variation obtained from simulated volumes and the ones obtained from measured volumes. [less ▲]

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See detailThe Bureaucracy of Crime : J. G. Ballard’s Cocaine Nights and the Speculative Thriller
Delville, Michel ULg

in Analele Universităţii Oradea - Seria Filologie, Fascicola Limba şi literatura (2000), 8

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See detailA four-parameter index of marrow dysplasia has predictive value for survival in myelodysplastic syndromes.
Tassin, Françoise ULg; Dewé, Walthère ULg; Schaaf, Nicole ULg et al

in Leukemia & Lymphoma (2000), 36(5-6), 485-96

Marrow dysplasia is a major characteristic of patients with myelodysplastic syndrome (MDS), along with marrow blastosis, cytopenia and cytogenetic anomalies. However, the impact of the degree of marrow ... [more ▼]

Marrow dysplasia is a major characteristic of patients with myelodysplastic syndrome (MDS), along with marrow blastosis, cytopenia and cytogenetic anomalies. However, the impact of the degree of marrow dysplasia on survival has not been fully assessed. In this retrospective analysis of 111 patients selected according to the IPSS criteria of MDS diagnosis, the presence or absence of 21 dysplasia characteristics recognizable in bone marrow smears stained by the May-Grunwald-Giemsa method was correlated with patient survival. Using Cox proportional hazards regression analysis, megaloblastosis (MEGALO), neutrophil agranularity (AGRAN) and hypogranularity (HYPOGRAN) were highly significant predictors (p < 0.005), and Pelger-Huet anomaly (PELGHUET) a significant predictor (p = 0.05), of patient survival. The regression analysis yielded a dysplasia-based risk index (DI) where DI = 1.26 MEGALO + 0.82 AGRAN - 1.08 HYPOGRAN + 0.45 PELGHUET. The two subgroups of 60 and 47 patients with DI < or = 0 and > 0 showed highly significant differences in median survivals (2.6 vs 1.1 yrs; p <0.0001). Multivariate analysis further showed that DI offered additional predictive power that was independent of that provided by the IPSS (p=0.002 and 0.001 respectively). Analysis of survival curves stratified for IPSS and DI showed that the additional predictive power offered by inclusion of the DI essentially concerned the IPSS low/INT-1 risk categories. Further stratification for age did not improve survival prediction. The data indicate that a set of 4 dysplasia parameters can offer some prediction for survival of MDS patients in addition to that provided by the IPSS. Further multicenter studies should aim at including some form of evaluation of the degree of dysplasia in prognostic systems. [less ▲]

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See detailLa gestion integrée des déchets solides de Kigali (Rwanda)
Culot, Marc ULg; Nzeyimana, François

in Echos du COTA (2000), (87), 6-9

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See detailA numerically efficient data analysis method with error map generation
Rixen, M.; Beckers, Jean-Marie ULg; Brankart, J. M. et al

in Ocean Modelling (2000), 2

The variational inverse model (VIM) for data analysis was already shown to be statistically equivalent to objective analysis (OA) provided the covariance function for the OA and the VIM reproducing kernel ... [more ▼]

The variational inverse model (VIM) for data analysis was already shown to be statistically equivalent to objective analysis (OA) provided the covariance function for the OA and the VIM reproducing kernel are identical. The VIM, however does not allow a direct derivation of the error field associated with the analysis. The purpose of the paper is to extend the one to one correspondance between the two analysis shemes by proposing a heuristic statistical error expression for the VIM. The numerical efficiency on analysis and error map generation of both methods is compared on quasi-synoptic and climatological data sets. It is shown that the VIM analysis and error map generation offers interesting numerical skills in both case studies. [less ▲]

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See detailVolume tables for small trees of larch (Larix sp.) in the southern part of Belgium
Rondeux, Jacques ULg; Pauwels, D.

in Forestry (2000), 73(1), 91-93

Volume tables have been constructed for European larch (Larix decidua Mill.), Japanese larch (Larix kaempferi (Lamb.) Carr.) and hybrid larch (Larix X eurolepis Henry) trees in the Ardenne (southern part ... [more ▼]

Volume tables have been constructed for European larch (Larix decidua Mill.), Japanese larch (Larix kaempferi (Lamb.) Carr.) and hybrid larch (Larix X eurolepis Henry) trees in the Ardenne (southern part of Belgium), which is a natural region located at elevations ranging from 340 to 550 m on mainly siliceous rocks. The application of the proposed tables is only for trees whose diameters (d.b.h.) are less than 22 cm over bark at 1.3 m above ground level. They are particularly useful for estimating total tree volume of trees (excluding branches) of early thinnings and volume increment of small-sized trees in genetic improvement experiments. The volume equations are based on data collected over a wide range of site conditions. In these regional volume tables, the volumes (total volume of the stem and volume to an upper diameter limit of 7 cm) are correlated with both d.b.h. and total height. [less ▲]

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See detailEvolution des connaissances sur la membrane du globule gras du lait: synthese bibliographique.
Danthine, Sabine ULg; Blecker, Christophe ULg; Paquot, Michel ULg et al

in Lait (2000), 80(2), 209-222

The milk fat globule is essentially an oil droplet enclosed in a protective 'membrane', partially derived from the plasma membrane of the lactating cell, and which assures the dispersion of the milk fat ... [more ▼]

The milk fat globule is essentially an oil droplet enclosed in a protective 'membrane', partially derived from the plasma membrane of the lactating cell, and which assures the dispersion of the milk fat in the milk plasma. This protective coat is generally called 'the milk fat globule membrane' (MFGM). This review examines the present state of knowledge on the MFGM. The topics dealt with are: origin and formation, isolation From milk, composition (lipids and proteins), structure (a new model is proposed), functional properties and the role that the MFGM plays in protection against lipolysis. [less ▲]

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See detailLe champ des études migratoires et ethniques en Belgique
Martiniello, Marco ULg

in La Revue Générale (2000), 135(10), 19-28

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See detailDetermination Of The Methionine Requirement Of Growing Double-Muscled Belgian Blue Bulls With A Three-Step Method
Froidmont, Eric; Beckers, Yves ULg; Thewis, André ULg

in Journal of Animal Science (2000), 78(1), 233-241

The three-step technique was used to determine the requirements of total amino acids (TAA) and the first-limiting amino acid (AA) in growing double- muscled Belgian Blue bulls (BBb). In Exp. 1, three ... [more ▼]

The three-step technique was used to determine the requirements of total amino acids (TAA) and the first-limiting amino acid (AA) in growing double- muscled Belgian Blue bulls (BBb). In Exp. 1, three double-muscled BBb weighing initially 306 ± 28 kg received a basal diet consisting of 30% meadow hay and 70% concentrate that was poor in digestible protein but had adequate NE because of continuous infusion of dextrose into the duodenum. The intestinal apparent digestibility of essential AA (EAA) was defined according to their duodenal and ileal flows. It averaged 72% but varied between 60% for Met and 79% for Arg. In Exp. 2, five double-muscled BBb (334 ± 22 kg) received the same diet supplemented with duodenal infusions of dextrose and four doses of Na-caseinate (28, 56, 84, and 112% of intestinal digestible dietary AA) in a 4 × 4 Latin square design with one additional animal. Nitrogen retention for the basal diet alone and the four increasing supplements of Na-caseinate reached 49, 61, 70, 80, and 86 g/d, respectively. Nitrogen utilization improved from 34.3% without Na-caseinate supplementation to a maximum of 40.6%, with the third dose supplying 788 g/d of apparently digestible AA. Based on patterns of plasma concentrations, Met, Phe, and Arg were probably the limiting AA when animals optimized N utilization. In Exp. 3, six double-muscled BBb (315 ± 25 kg) fed the basal diet received duodenal infusions of dextrose and AA, equivalent to the third dose in Exp. 2, except for digestible Met (9.3, 14.4, 18.4, 22.4, 26.4, and 30.4 g/d) in a 6 × 6 Latin square design. The Met requirement was close to 26.4 g/d on the basis of N retention. [less ▲]

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See detailEvidence For Specific And Non-Covalent Binding Of Lipids To Natural And Recombinant Mycobacterium Bovis Bcg Hsp60 Proteins, And To The Escherichia Coli Homologue Groel
De Bruyn, J.; Soetaert, K.; Buyssens, P. et al

in Microbiology-Sgm (2000), 146

Heat-shock proteins (Hsps) from various origins are known to share a conserved structure and are assumed to be key partners in the biogenesis of proteins. Fractionation of the mycobacterial Hsp60, a 65 ... [more ▼]

Heat-shock proteins (Hsps) from various origins are known to share a conserved structure and are assumed to be key partners in the biogenesis of proteins. Fractionation of the mycobacterial Hsp60, a 65 kDa protein also called Cpn60, from Mycobacterium bovis BCG zinc-deficient culture filtrate on phenyl-Sepharose followed by Western blotting revealed the existence of four Hsp60-1 and Hsp60-2 forms, based on their hydrophobicity behaviour. Hsp60-2 species were further purified by ion-exchange chromatography and partial amino acid sequences of cyanogen bromide (CNBr) peptides of purified Hsp60-2 species showed identity with the amino acid sequence deduced from the hsp60-2 gene, indicating that the various Hsp60-2 forms are encoded by the same gene. In addition, the mycobacterial Hsp60-2 was overexpressed in E. coli using the pRR3Hsp60-2 plasmid and analysed on phenyl-Sepharose. The elution pattern of the recombinant Hsp60-2, as well as that of Escherichia coli GroEL, was similar to that of the native Hsp60-2 from the culture filtrate of M. bovis BCG and entirely different from that of the mycobacterial antigen 85. Extraction of mycobacterial Hsp60-2 forms, recombinant BCG Hsp60-2 and E. coli GroEL with organic solvents releases various amounts of non-covalently bound lipids. The presence of lipids on Hsp60-2 was confirmed by labelling M. bovis BCG with radioactive palmitate. The radioactivity was specifically associated with Hsp60 in the aqueous phase and the 19 and 38 kDa lipoproteins in the Triton X-114 phase. Analysis of the lipids extracted from purified Hsp60-2, recombinant BCG Hsp60-2 and E. coli GroEL by TLC showed the same pattern for all the samples. Acid methanolysis of the lipids followed by GC analysis led to the identification of C(16:0), C(18:0) and C(18:1) as the major fatty acyl constituents, and of methylglycoside in these proteins. Altogether, these data demonstrate that lipids are non-covalently bound to Hsp60-2 and homologous proteins. [less ▲]

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See detailDiscretization of Sources of Integral Operators
Tarhasaari, T.; Kettunen, L.; Geuzaine, Christophe ULg

in IEEE Transactions on Magnetics (2000), 36(4), 659--662

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See detailConséquences de l'infection des cervidés par des alpha-herpèsvirus apparentés au virus de l'IBR
Keuser, V.; Thiry, Etienne ULg

in Point Vétérinaire (2000), 31

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See detailLe rôle du maître de stage : présentation de cinq principes d'action visant une amélioration de la relation formatrice
Chenu, Florent ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (1-2), 92-107

Cet article présente les conclusions d'un mémoire de Licence en Sciences de l'Education. Le but principal de celui-ci était la formulation de principes d'action visant une amélioration de la relation ... [more ▼]

Cet article présente les conclusions d'un mémoire de Licence en Sciences de l'Education. Le but principal de celui-ci était la formulation de principes d'action visant une amélioration de la relation formatrice maître de stage-stagiaire pour les agrégés de l'enseignement secondaire inférieur. Ces principes d'action ont été mis au point en grande partie sur la base d'une étude des représentations des pratiques du maître de stage chez des étudiants, chez des professeurs de Haute Ecole et chez des maîtres de stage eux-mêmes. Dans un premier temps, la problèmatique dans laquelle ce travail s'est inscrit sera définie. Viendra ensuite une brève explication de la méthodologie utilisée pour l'étude des représentations. Enfin, les cinq principes d'action seront présentés et étayés par quelques résultats. [less ▲]

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See detailComment apprendre aux élèves à développer une démarche experte et réflexive de résolution de problèmes
Fagnant, Annick ULg; Demonty, Isabelle ULg; Lejong, Michèle ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 51-65

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See detailDielectronic structure of 2l-1s Transitions of Multicharged Ions of Argon with nuclear charges Z = 10 - 17
Biémont, Emile ULg; Quinet, Pascal ULg; Faenov, A.Ya et al

in Physica Scripta (2000), 61

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See detailAnalysis of plasma IGF-I hormone levels in Holstein-Friesian Heifers
Horvai-Szabo, M.; Renaville, Robert ULg; Dohy, J.

in Journal of Dairy Science (2000), 83(suppl 1), 48

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See detailLes affections du système urinaire du chat : II. Maladies du tractus urinaire inférieur : aspects diététiques
Jeusette, I.; Tonglet, C.; Istasse, Louis ULg et al

in Annales de Médecine Vétérinaire (2000), 144

This synthesis aims to summarize the specific dietary requirements for prevention or nutritional treatment of feline lower urinary tract diseases and overall urolith's formation. Since aetiologies are ... [more ▼]

This synthesis aims to summarize the specific dietary requirements for prevention or nutritional treatment of feline lower urinary tract diseases and overall urolith's formation. Since aetiologies are diverse and the epidemiological knowledge are changing within the recent year, empirical treatment of the pathology isn't anymore advisable. Symptomatology and aetiology are briefly presented and the different dietary factors to be taken into consideration in urolith's formation are discussed. Chemical composition of petfoods to treat or prevent struvite or calcium oxalate uroliths are compared [less ▲]

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See detailLa prescription de l'action publique
Jacobs, Ann ULg

in Journal des Tribunaux (2000)

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See detailComparaison de l'usage d'huiles d'origine végétale ou minérale pour la lubrification de chaines de tronconneuse.
Bieswal, Marc; Debouche, Charles ULg; van Belle, Laurent

in Silva Belgica (2000), 107(2), 18-21

Des études en laboratoire ont montré que les huiles végétales présentent un pouvoir lubrifiant supérieur aux huiles minérales dans le domaine de la lubrification limite (Kabuya 1995). Par ailleurs, des ... [more ▼]

Des études en laboratoire ont montré que les huiles végétales présentent un pouvoir lubrifiant supérieur aux huiles minérales dans le domaine de la lubrification limite (Kabuya 1995). Par ailleurs, des chiffres avancés dans la littérature ou par des fournisseurs de lubrifiants annoncent la possibilité de réduire la consommation de lubrifiant en passant à un lubrifiant à base d'huile végétale. Des chiffres de réduction d'usure sont aussi avancés par des constructeurs de tronçonneuses. L'essai décrit dans cet article n'a pas permis de confirmer ces réductions de consommation et de frottement. [less ▲]

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See detailDispersed Pd-Ag alloys for selective production of olefins from chlorinated alkanes
Heinrichs, Benoît ULg; Schoebrechts, Jean-Paul; Pirard, Jean-Paul ULg

in Studies in Surface Science and Catalysis (2000), 130

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See detailCompte-rendu de l'ouvrage de Claudine Poulouin : Le temps des origines
Donneau, Olivier ULg

in Hieros : Bulletin Annuel de la Société Belgo-luxembourgeoise d'Histoire des Religions (2000), 4

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See detailSeparation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte.
Fillet, Marianne ULg; Bechet, Isabelle; Fotsing, Lucas ULg et al

in Biomedical Chromatography : BMC (2000), 14(1), 12-3

Separation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte.

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See detailEvidence for decoupling of atmospheric CO2 and global climate during the Phanerozoic eon
Veizer, J.; Godderis, Y.; François, Louis ULg

in Nature (2000), 408(6813), 698-701

Atmospheric carbon dioxide concentrations are believed to drive climate changes from glacial to interglacial modes', although geological(1-3) and astronomical(4-6) mechanisms have been invoked as ultimate ... [more ▼]

Atmospheric carbon dioxide concentrations are believed to drive climate changes from glacial to interglacial modes', although geological(1-3) and astronomical(4-6) mechanisms have been invoked as ultimate causes. Additionally, it is unclear(7,8) whether the changes between cold and warm modes should be regarded as a global phenomenon, affecting tropical and high-latitude temperatures alike(9-13), or if they are better described as an expansion and contraction of the latitudinal climate zones, keeping equatorial temperatures approximately constant(14-16). Here we present a reconstruction of tropical sea surface temperatures throughout the phanerozoic eon (the past similar to 550 Myr) from our database(17) of oxygen isotopes in calcite and aragonite shells. The data indicate large oscillations of tropical sea surface temperatures in phase with the cold-warm cycles, thus favouring the idea of climate variability as a global phenomenon. But our data conflict with a temperature reconstruction using an energy balance model that is forced by reconstructed atmospheric carbon dioxide concentrations(18). The results can be reconciled if atmospheric carbon dioxide concentrations were not the principal driver of climate variability on geological timescales for at least one-third of the Phanerozoic eon, or if the reconstructed carbon dioxide concentrations are not reliable. [less ▲]

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See detailLa lecture, un ouvrage féminin: Enquête sur les pratiques de lecture auprès des jeunes de14-15 ans en Communauté française de Belgique
Lafontaine, Dominique ULg; Schillings, Patricia ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (2000), 47-48

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See detail. Modulation of the biological action of bovine growth hormone by passive immunization in hypophysectomised rat
Jacqmin, Sandrine; Vleurick, Lieve; Renaville, Robert ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 3

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See detailOestrogenotherapie apres la menopause et protection cardio-vasculaire: discordance entre les observations epidemiologiques et les resultats d'essais therapeutiques.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 886-8

Based upon the positive results of a large epidemiological study and the negative results of an interventional clinical trial recently published in the New England Journal of Medicine, we will briefly ... [more ▼]

Based upon the positive results of a large epidemiological study and the negative results of an interventional clinical trial recently published in the New England Journal of Medicine, we will briefly discuss the impact of estrogen replacement therapy on the protection against coronary heart disease in postmenopausal women. [less ▲]

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See detailAntiobesity pharmacotherapy in the management of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabetes/Metabolism Research & Reviews (2000), 16(2), 114-24

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction ... [more ▼]

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction should be considered as a key objective. In this respect, several antiobesity drugs have demonstrated potential. However, while fenfluramine and dexfenfluramine have been shown to promote weight loss and to directly improve insulin sensitivity, being two mechanisms contributing to better blood glucose control in obese Type 2 diabetic patients, they were recently withdrawn due to safety problems. Sibutramine, a new selective norepinephrine and serotonin reuptake inhibitor, promotes weight loss by decreasing food intake, an effect which leads to a mild improvement (significant in patients losing > or =5% of initial body weight) of blood glucose control in obese diabetic patients. Similarly, orlistat, a selective gastrointestinal lipase inhibitor which increases faecal fat losses, enhances diet-induced weight reduction and improves both blood glucose control and vascular risk profile, especially dyslipidaemia, in obese Type 2 diabetic patients. Further studies are required to better identify good responders to pharmacotherapy and specify the role of antiobesity agents in the overall long-term management of obese subjects with Type 2 diabetes. Other novel pharmacological approaches deserve further consideration, for instance beta-3 agonists aiming to increase energy expenditure, drugs interfering with tumor necrosis factor-alpha (TNF-alpha) or free fatty acid release by the adipose tissue or agents that slow gastric emptying. However, until now, results regarding efficacy and/or safety have been disappointing or preliminary in humans. [less ▲]

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See detailFrom neurophysiology to genetics: cortical information processing in migraine underlies familial influences--a novel approach
Sandor, P. S.; Afra, J.; Proietti Cecchini, A. P. et al

in Functional Neurology (2000), 15(Suppl 3), 68-72

Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory ... [more ▼]

Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors. [less ▲]

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See detailThe relationships between episodic memory, working memory, and executive functions: The contribution of the prefrontal cortex
Van der Linden, Martial ULg; Meulemans, Thierry ULg; Marczewski, Philippe et al

in Psychologica Belgica (2000), 40(4), 275-297

Discusses the neurophysiological functions of the prefrontal cortex related to memory processes. Functional brain imaging studies have revealed that distinct regions of the prefrontal cortex are engaged ... [more ▼]

Discusses the neurophysiological functions of the prefrontal cortex related to memory processes. Functional brain imaging studies have revealed that distinct regions of the prefrontal cortex are engaged in episodic memory operations, with some regions apparently part of multiple networks subserving different memory abilities. The prefrontal cortex is also involved in shifting processes. Working memory processes within the dorsolateral and ventrolateral frontal cortex are organized according to the type of processing required rather than the nature of the information being processed. The binding of contextual information, both incidentally and intentionally, is the most crucial process involved in episodic memory. Inhibition control involves not only bilateral prefrontal areas, but also posterior regions and subcortical structures, but the specific role of the cerebral areas is not clear at present. [less ▲]

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See detailRéflexions sur l'avenir de la Belgique et de Bruxelles
Martiniello, Marco ULg; Swyngedouw, Marc

in Utinam : Revue de Sociologie et d'Anthropologie (2000), 3

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See detailIdentification of animals treated with bovine somatotropin : a new non-isotopic detection system for bST
Baronheid, Christophe; Bertozzi, Carlo; Renaville, Robert ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4

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See detailTraitement des cephalees de tension
Schoenen, Jean ULg

in Revue Neurologique (2000), 156(Suppl 4), 487-92

The scientific basis of tension- type headache suffers from the lack of precise pathophysiological knowledge and the heterogenecity of this disorder. Treatment of acute tension-type headache episodes is ... [more ▼]

The scientific basis of tension- type headache suffers from the lack of precise pathophysiological knowledge and the heterogenecity of this disorder. Treatment of acute tension-type headache episodes is more effective with an NSAIDs (ibuprofen 400-800mg, naproxen 550-825mg, ketoprofen 50-75mg) than with aspirin or paracetamol. Caffein containing preparations of NSAIDs are slightly superior, but should not be taken frequently to avoid headache chronification. For chronic tension-type headache, relaxation therapies with EMG biofeedback and tricyclics have about the same efficacy rate of 40-50p.100. Physical therapy and acupuncture are in general less effective. There is thus clearly a need for better strategies, e.g. combination of available therapies and novel approaches. [less ▲]

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See detailLe rôle du thymus dans la physiopathologie du diabète de type 1
Geenen, Vincent ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2000), 155

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See detailClinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantation.
Baron, Frédéric ULg; Gothot, André ULg; Salmon, Jean ULg et al

in British Journal of Haematology (2000), 111(3), 745-53

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome ... [more ▼]

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome, termed autologous GVHD has notable anti-tumour activity in animal studies. We intended to induce autologous GVHD with CyA in patients undergoing an autologous HSCT. We prospectively studied 118 patients with miscellaneous malignancies undergoing an autologous HSCT with low-dose CyA to characterize the clinical syndrome, its frequency and clinical course, and to determine the factors affecting its incidence. Patients received CyA from d -1 through to d 28, first starting at 2 mg/kg intravenously and then orally as soon as feasible. The dose was adjusted to achieve pre-dose blood levels around 100 ng/ml. A skin biopsy was performed when a skin rash was observed. Thirty-three percent of the patients developed clinical GVHD: clinical stage 1 in 21 patients, stage 2 in seven patients, and stage 3 in three patients. Although total body irradiation (TBI) or high-dose cyclophosphamide were previously thought to be needed, autologous GVHD occurred in five out of 12 patients (42%) after a preparative regimen with high-dose melphalan alone. Autologous GVHD was significantly more frequent in patients older than 33 years, in patients who had received high doses of granulocyte-macrophage colony forming units (CFU-GM) and in those with a diagnosis of myeloid malignancy, compared with those with lymphoid malignancies or solid tumours. A significant negative association was also found with HLA-DR6. In lymphoma patients, GVHD occurred more frequently in advanced disease than in first or second complete remission (CR1-2) patients. All other factors studied were not predictive for GVHD. In conclusion, CyA-induced GVHD is reproducibly and safely induced with doses of CyA adapted to achieve blood levels around 100 ng/ml. In retrospective analysis, there was no survival advantage for patients with GVHD. Phase III trials with this approach are needed to evaluate its anti-tumoral effect. [less ▲]

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See detailLes encéphalopathies à herpèsvirus bovins
Meyer, Gilles; D'Offay, Jean; Thiry, Etienne ULg

in Point Vétérinaire (2000), 31

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See detailDe l'inapplicabilite de certaines recommandations therapeutiques en pratique: l'exemple du remboursement des medicaments hypolipidemiants en Belgique.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(4), 260-4

International guidelines from the Task Force of European and other Societies on Coronary Prevention and national guidelines from the Belgian Lipid Club recently emphasized the potential interest of ... [more ▼]

International guidelines from the Task Force of European and other Societies on Coronary Prevention and national guidelines from the Belgian Lipid Club recently emphasized the potential interest of adequate management of patients with even moderate hypercholesterolaemia. However, current criteria for the reimbursement of lipid-lowering drugs in Belgium do not allow to follow these guidelines. A solution should be urgently found in order to bridge the gap and permit practitioners, after diet failure, to effectively prescribe lipid-lowering agents in patients who should benefit in priority of such a treatment. It is certainly the case in secondary prevention as well as, in high risk individuals, in primary prevention, i.e. in situations where these drugs have provided enough evidence of their efficacy with an acceptable cost-benefit ratio. [less ▲]

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See detailEffects of propofol on endothelial cells subjected to a peroxynitrite donor (SIN-1).
Mathy, Marianne ULg; Mouithys-Mickalad, Ange ULg; Kohnen, S. et al

in Anaesthesia (2000), 55(11), 1066-71

We investigated the effect of propofol on endothelial cells subjected to the peroxynitrite (ONOO-) donor 3-morpholino sydnonimine (SIN-1). Cells were incubated overnight with 0.5, 1.0 or 2.0 mM SIN-1 ... [more ▼]

We investigated the effect of propofol on endothelial cells subjected to the peroxynitrite (ONOO-) donor 3-morpholino sydnonimine (SIN-1). Cells were incubated overnight with 0.5, 1.0 or 2.0 mM SIN-1, with or without 10-3 M propofol (Diprivan). Cytotoxicity, assessed by measuring the release of pre-incorporated 51Cr, increased when the concentration of SIN-1 increased, and was significantly decreased by 10-3 M propofol (90%, 78% and 28% of protection against 0.5, 1.0 and 2.0 mM SIN-1, respectively). Cell protection against 1 mM SIN-1 was tested with 0.03-1.0 mM propofol and this was compared to tyrosine, a target molecule for peroxynitrite. Propofol protected cells in a dose-dependent manner (r = 0.98; p < 0.001) and was as effective as tyrosine. Finally, using high-performance liquid chromatography, we demonstrated that propofol reacted with ONOO- more rapidly than did tyrosine, inhibiting nitrotyrosine formation. In the absence of propofol, 3.5 mM ONOO- with 1 mM tyrosine yielded 39.6% nitrotyrosine, but nitrotyrosine was not produced when 5 mM propofol was added. We conclude that propofol protects endothelial cells against the toxicity of ONOO-. The anti-oxidant properties of propofol can be partially attributed to its scavenging effect on peroxynitrite, a property that might be relevant in pathological situations involving a significant contribution of peroxynitrite to tissue damage. [less ▲]

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See detailGenes upregulated during castration-induced rat prostatic apoptosis: cloning and characterization of new cDNAs.
Bruyninx, M.; Ammar, H.; Reiter, E. et al

in BJU International (2000), 85(9), 1134-42

OBJECTIVE: To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS: Differential display of mRNAs from 3-day ... [more ▼]

OBJECTIVE: To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS: Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybridized to confirm the positive regulation of the candidates and to follow the change in their expression in the involuting rat prostate, and in thymocytes of dexamethazone-treated rats. RESULTS: Five cDNAs were cloned: one encoding ribosomal protein L7, one coding for the insulin-like growth factor binding protein-3 (IGFBP-3), and three whose products are unknown. After castration, all five genes had expression kinetics that closely paralleled the proportion of prostatic epithelial cells undergoing apoptosis. The gene encoding L7 and two of the unknown genes were also upregulated in glucocorticoid-induced programmed death in thymocytes. In addition to the IGFBP-3 gene, those coding for proteins IGFBP-4, -5 and -6 were also overexpressed in the involuting prostate of androgen-deprived rats. CONCLUSION: Five new genes were identified that are up-regulated during castration-induced rat prostate apoptosis, three of which are potentially involved in the common intracellular pathway leading to programmed cell death. [less ▲]

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See detailL'etude clinique du mois. L'etude STOP-2 dans l'hypertension arterielle du sujet age.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(1), 64-6

After the demonstration of the efficacy of beta-blockers or diuretics versus placebo to prevent cardiovascular complications in elderly hypertensive patients in the first STOP-Hypertension study in 1991 ... [more ▼]

After the demonstration of the efficacy of beta-blockers or diuretics versus placebo to prevent cardiovascular complications in elderly hypertensive patients in the first STOP-Hypertension study in 1991, a Swedish group published at the end of 1999 the STOP-2 Hypertension study. The latter randomised trial showed in a similar population that the cardiovascular protection of more recent antihypertensive agents such as calcium antagonists and angiotensin-converting-enzyme inhibitors is similar to that of the conventional antihypertensive drugs used in the first study. In fact, the degree of blood pressure control appears to be more important than the type of antihypertensive drugs used, and this conclusion is reinforced by the observation that numerous patients should rapidly be treated by more than one antihypertensive agent to reach blood pressure targets. [less ▲]

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See detailFeed restriction in young bulls alters the onset of puberty in relationship with plasma insulin-like growth factor-I (IGF-I) and IGF-binding proteins.
Renaville, Robert ULg; Van Eenaeme, Christian ULg; Breier, B. H. et al

in Domestic Animal Endocrinology (2000), 18(2), 165-76

The objectives of this study were to evaluate the effect of feed restriction and re-alimentation on the onset of puberty and IGF status in peripubertal male calves and to compare the radioimmunoassay (RIA ... [more ▼]

The objectives of this study were to evaluate the effect of feed restriction and re-alimentation on the onset of puberty and IGF status in peripubertal male calves and to compare the radioimmunoassay (RIA) and western ligand blotting (WLB) methods for bovine IGFBP-2. Twelve prepubertal 290 d-old Belgian Blue bulls (mean weight: +/- 290 kg) were randomly assigned in three groups: a control group (NG; n = 4) receiving a classic fattening diet to induce "normal" growth (1.48 kg/d), a feed restricted group (RG; n = 4) to obtain reduced growth (0.50 kg/d) and, a severely restricted group (SG; n = 4) to nearly stop growth (0.08 kg/d). The feed restriction period was maintained over a period of 114 d. After the period of differential feeding, all animals received the control feed regime over a period of 100 d. Blood samples were collected at fortnightly intervals. Circulating IGF-I was measured by RIA whereas plasma IGFBPs was evaluated by WLB; IGFBP-2 was additionally quantified by RIA procedure. At the beginning of the trial, IGF-I levels were low (<100 ng/ml) and similar in the three groups in accordance with prepubertal status. In the NG group, a progressive rise in IGF-I was observed from Day 42 to Day 142 whereas in the RG and SG groups, IGF-I levels did not change until the experimental restriction period ended. The delay of the rise in plasma IGF-I was longer for the SG group, IGF-I remained low until 2 wk after the end of the period of restricted feeding. Surprisingly, although differences were detected for IGF-I levels between the three groups, the IGFBP-2 and -3 data, evaluated by WLB could only discriminate between NG and SG group and not between NG and RG. However, by using a RIA method, an IGFBP-2 decrease was observed in the NG group coincident with increasing IGF-I levels. For both RG and SG groups, IGFBP-2 levels remained high throughout the feed restriction period whereas plasma IGFBP-2 levels declined upon feeding in both groups. During this feed restriction period, IGFBP-2 was significantly lower in NG than in RG or SG groups. Moreover, SG group animals had higher levels in plasma IGFBP-2 than RG animals. In conclusion, puberty is characterized by developmental changes in plasma IGF-I and IGFBPs that were altered by feed restriction. Moreover, RIA evaluation of plasma IGFBP-2 is able to better reflect group differences than WLB. [less ▲]

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See detailLa Francophonie à travers les médias africains. Le cas de la région des Grands Lacs africains
Kabamba, Bob ULg

in Studia Diplomatica (2000), Vol. LIII: 2000(n°3),

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See detailBasic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2.
Mounier, C. M.; Luchetta, P.; Lecut, Christelle ULg et al

in European Journal of Biochemistry (2000), 267(16), 4960-9

Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q ... [more ▼]

Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q mutant prolong the lag time of thrombin generation in human platelet-rich plasma with similar efficiency, indicating that hGIIA exerts an anticoagulant effect independently of phospholipid hydrolysis under ex vivo conditions. Charge reversal of basic residues on the interfacial binding surface (IBS) of hGIIA leads to decreased ability to inhibit prothrombinase activity, which correlates with a reduced affinity for factor Xa, as determined by surface plasmon resonance. Mutation of other surface-exposed basic residues, hydrophobic residues on the IBS, and His48, does not affect the ability of hGIIA to inhibit prothrombinase activity and bind to factor Xa. Other basic, but not neutral or acidic, mammalian secreted phospholipases A2 (sPLA2s) exert a phospholipid-independent inhibitory effect on prothrombinase activity, suggesting that these basic sPLA2s also bind to factor Xa. In conclusion, this study demonstrates that the anticoagulant effect of hGIIA is independent of phospholipid hydrolysis and is based on its interaction with factor Xa, leading to prothrombinase inhibition, even under ex vivo conditions. This study also shows that such an interaction involves basic residues located on the IBS of hGIIA, and suggests that other basic mammalian sPLA2s may also inhibit blood coagulation by a similar mechanism to that described for hGIIA. [less ▲]

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See detailEvaluation of Accuracy of Pulse Oximetry in Newborn Calves
Uystepruyst, Christophe; Coghe, Joost; Bureau, Fabrice ULg et al

in Veterinary Journal (2000), 159(1), 71-76

In human medicine, pulse oximetry is widely used to measure non-invasively and accurately the percentage of oxygen saturation of arterial haemoglobin (SpO(2)). Recently, pulse oximetry has been used in ... [more ▼]

In human medicine, pulse oximetry is widely used to measure non-invasively and accurately the percentage of oxygen saturation of arterial haemoglobin (SpO(2)). Recently, pulse oximetry has been used in calves, but its accuracy has not been evaluated in newborn calves. The purpose of this study was to evaluate the accuracy of a pulse oximeter in newborn calves by comparing SpO(2) with arterial oxyhaemoglobin saturation (SaO(2)) obtained by use of a blood gas analyser. Fifty-five newborn calves were investigated from birth to 20 days old. Pulse oximetry readings and arterial blood samples were performed 5, 15, 30, 45, 60 min, 2, 3, 6, 12, 24 h and 1 and 3 weeks after birth. The transmission-type sensors of the pulse oximeter were fixed at the recommended site in the bovine species (at the base of the calf tail, where the skin had been shaved and was not pigmented) and arterial blood samples were withdrawn from the subclavian artery and analysed for SaO(2). Five-hundred paired data of SaO(2) and mean SpO(2)(mSpO(2)) were collected. Linear regression of the pooled data indicated a highly significant correlation of mSpO(2) with SaO(2) (r = 0.87;P< 0.001; mSpO(2) = 15.8 + 0.84 SaO(2)). The overall data bias value was positive (+2.1%), which indicated that the pulse oximeter tended to overestimate the SaO(2). The bias value for each SaO(2) category tended to become higher for lower ranges of SaO(2). Precision was also lower when SaO(2) values were low. The lower the SaO(2) value, the higher the positive bias (overestimation) and the lower the precision. These results suggest that pulse oximetry provides a relatively accurate non-invasive, immediate and portable method to monitor SaO(2) and to evaluate objectively the pulmonary function effectiveness in newborn calves during their adaptation to extra-uterine life. [less ▲]

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See detailCourbes de croissance de microorganismes : modélisation et linéarisation
Henry, Valérie ULg; Salengros, Paul

in Mathématique et Pédagogie (2000), 127

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See detailChemical profiles of Amblystegium riparium, Fontinalis antipyretica and Rhynchostegium riparioides in the Grand-Duchy of Luxembourg
Vanderpoorten, Alain ULg; Ector, L.; Hoffmann, L.

in Nova Hedwigia (2000), 71(1-2), 209-221

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See detailManagement perspectives on a deep aquifer system for rural water supply in Olt and Valcea counties - Romania
Dinu, Irina; Albu, Marius; Moldoveanu, Victor et al

in Lakes & Reservoirs : Research & Management (2000), 5

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See detailLe mélèze, un atout dans les objectifs de diversification de notre sylviculture.
Pauwels, Dominique; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(2), 6-12

Le présent article s'attachera à présenter l'essence, son tempérament, son écologie, quelques critères permettant d'orienter le choix de la station et de l'espèce ainsi que les qualités et usages qu'on ... [more ▼]

Le présent article s'attachera à présenter l'essence, son tempérament, son écologie, quelques critères permettant d'orienter le choix de la station et de l'espèce ainsi que les qualités et usages qu'on peut en attendre. Cette présentation ne se veut pas exhaustive, elle est volontairement destinée à l'usage pratique des gestionnaires et propriétaires forestiers désireux de planter du mélèze. [less ▲]

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See detailDescriptio Urbis Romae
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (2000)

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See detailMutation in exon 5 of bovine prolactin gene is not associated with milk traits in Holstein bulls.
Parmentier, Isabelle; Gengler, Nicolas ULg; Laliberte, P. et al

in Journal of Animal Science (2000), 78(Suppl 1),

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See detailNitrated proteins in bronchoalveolar lavage fluid of patients at risk of ventilator-associated bronchopneumonia.
Mathy, Marianne ULg; Damas, Pierre ULg; Nys, Monique ULg et al

in European Respiratory Journal (2000), 16(2), 296-301

The study was designed to identify markers of oxidative injury, related to the nitric oxide derived cascade, in bronchoalveolar lavage (BAL) fluid from intensive care patients suspected of ventilator ... [more ▼]

The study was designed to identify markers of oxidative injury, related to the nitric oxide derived cascade, in bronchoalveolar lavage (BAL) fluid from intensive care patients suspected of ventilator-associated pneumonia (VAP) and/or acute respiratory distress syndrome (ARDS). Thirty-eight patients developing VAP and/or ARDS (VAP/ARDS group) were compared to 20 ventilated patients without VAP/ARDS (control group). Myeloperoxidase (MPO) and elastase, taken as markers of neutrophil activation were measured by enzymatic techniques, and nitrated proteins (NTPs) by an immunological method. The cytotoxicity of the BAL fluid was tested using cultured human epithelial alveolar cells by the release of pre-incorporated 51Cr. Mean NTP concentration and, MPO and elastase activities were different between the VAP/ARDS and control groups (p<0.05 for NTPs; p<0.005 for MPO; p<0.005 for elastase). NTP concentration correlated with MPO and elastase activity and neutrophil number (r=0.93, 0.91 and 0.87, respectively), but not to protein concentration and arterial oxygen tension/inspiratory oxygen fraction. The cytotoxicity of BAL correlated with NTP concentration (r=0.92) and MPO activity (r=0.89). It was concluded that the concentrations of nitrated proteins in bronchoalveolar lavage fluid correlated with the oxidant activity of neutrophils and that, bronchoalveolar lavage fluid cytotoxicity was correlated with the nitrated protein concentration and may be mediated by oxidants. [less ▲]

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See detailTechnique for a rapid and efficient purification of the SHV-1 and PSE-2 beta-lactamases.
Bouillenne, Fabrice ULg; Matagne, André ULg; Joris, Bernard ULg et al

in Journal of Chromatography. B : Biomedical Sciences and Applications (2000), 737(1-2), 261-5

A simple procedure is described which results in an optimised resolution in molecular sieve chromatography. A sample exhibiting a large initial volume (about 20 ml) and conditioned in a buffer of low ... [more ▼]

A simple procedure is described which results in an optimised resolution in molecular sieve chromatography. A sample exhibiting a large initial volume (about 20 ml) and conditioned in a buffer of low ionic strength (<20 mM) by filtration through a 53-ml G25 molecular sieve column, is adsorbed on a 1.7-ml ion-exchange (SOURCE) column. The proteins are released by a 10-ml pulse of 1 M NaCl and the eluate directly injected onto a 120-ml Sephacryl S100-HR column. The very low volume of the eluate ensures optimal conditions and resolution for the molecular sieving process. The method is applied as the polishing step in the purification of the SHV-1 and PSE-2 beta-lactamases. It could easily be scaled up for the treatment of larger samples. [less ▲]

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See detailAssessment of Complex Perineal Fistulas
Bruyninx, Luc ULg; Meunier, Paul ULg

in Acta Chirurgica Belgica (2000), 100(3, May-Jun), 115-7

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See detailMicropore size distributions of activated carbons
Blacher, Silvia ULg; Sahouli, Bendida; Heinrichs, Benoît ULg et al

in Langmuir (2000), 16(16), 6754-6756

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See detailControl of perimenstrual flares of perioral dermatitis by isotretinoin
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Journal of Dermatological Treatment (2000), 11

BACKGROUNDS: Some cases of perioral dermatitis (POD) appear in young women after the interruption of oral contraception. Perimenstrual POD flares may also occur. Blue-brown, post-inflammatory macules and ... [more ▼]

BACKGROUNDS: Some cases of perioral dermatitis (POD) appear in young women after the interruption of oral contraception. Perimenstrual POD flares may also occur. Blue-brown, post-inflammatory macules and atrophic scarring often persist. Conventional treatment modalities include topical and oral tetracyclines, topical metronidazole and oral contraceptives. However, such therapies mau fail or offer only transient results. Isotretinoin efficacy was reported in a patient with difficult-to-treat POD. METHODS: We studied the outcome of a 6-month course of isotretinoin with a 1-year follow-up in 14 women suffering from chronic or recurrent POD refractory to or dependent on long-term conventional treatments. The isotretinoin dosing regiments were based on acne management guidelines. RESULTS: At 1-year follow-up, 12 of 14 (85,7 %) of the women remained free of POD recurrences, one patient (7,1 %) experienced a significant improvement, and one patient (7,1 %) showed only transient improvement during therapy, and rapidly relapsed after completing two 6-month treatment courses. The muco-cutaneous side effects were similar to those already known for isotretinoin. No other adverse effects occured. CONCLUSION: Isotretinoin represents a valuable therapeutic alternative for women suffering from chronic or recurrent POD refractory to or dependent on conventional treatment options. [less ▲]

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