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See detailRound Table Conference on Mediators of Sepsis--Brussels, Belgium, March 21-23, 1992
Lamy, Maurice ULg; Thijs, L. G.

in Intensive Care Medicine (1994), 20(3), 238-41

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See detailDie monofrequente Oszilloresistometrie - Möglichkeiten und Grenzen eines nichtinvasiven Verfahrens zur Atemwiderstandsmessung beim Kalb
Reinhold, Petra; Close, Roland; Lekeux, Pierre ULg

in Deutsche Tierarztliche Wochenschrift (1994), 101(4), 146-150

The monofrequency forced oscillation technique (MFOT) has been found to be a simple, reproducible, fast and accurate method to carry out lung function testing in calves even under field conditions. If ... [more ▼]

The monofrequency forced oscillation technique (MFOT) has been found to be a simple, reproducible, fast and accurate method to carry out lung function testing in calves even under field conditions. If some technical as well as methodological requirements are taken into account, pulmonary or respiratory resistance can be assessed by means of the parameter oscillatory resistance (Ros). Furthermore, several Ros derived parameters are available for describing the functional status of the central bronchial system. Due to the low variability caused by methodological or intraindividual reasons, the MFOT represents a very qualified method for intraindividual studies. Comparing measuring results of different subjects, a higher biologically caused variance has to be taken into account. [less ▲]

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See detailMeningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient
Snoeck, R.; Gérard, M.; Sadzot-Delvaux, Catherine ULg et al

in Journal of Medical Virology (1994), 42(4), 338-347

Varicella zoster virus (VZV) is recognized as one of the major viral pathogens reactivated in patients with the acquired immune deficiency syndrome (AIDS). We report the case of meningoradiculoneuritis in ... [more ▼]

Varicella zoster virus (VZV) is recognized as one of the major viral pathogens reactivated in patients with the acquired immune deficiency syndrome (AIDS). We report the case of meningoradiculoneuritis in an AIDS patient, associated with the isolation in the cerebrospinal fluid (CSF) of a thymidine kinase (TK)-deficient, acyclovir (ACV)-resistant strain of VZV. Although the virus was sensitive in vitro to phosphonoformate (PFA), the patient did not improve during PFA therapy and finally died. Several VZV strains isolated from this patient (including two isolates from the patient's CSF) were analyzed for their TK activity and subsequently the viral TK gene was sequenced showing a major deletion leading to a truncated protein. Their susceptibility to several antiviral agents including ACV, PFA, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 9-beta-D-arabinofuranosyladenine (vidarabine), (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (HPMPC), and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) was evaluated. All the virus strains isolated from this patient remained sensitive to HPMPA and HPMPC, pointing to the potential usefulness of these acyclic nucleoside phosphonates for the treatment of ACV-resistant VZV infections in immunocompromised patients. (C) 1994 Wiley-Liss, Inc. [less ▲]

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See detailHigh-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery
Janssens, Marc ULg; Joris, Jean ULg; David, Jean-Louis et al

in Anesthesiology (1994), 80

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See detailBehavioural study of hybridization between Barbus barbus and Barbus meridionalis
Poncin, Pascal ULg; Jeandarme, J.; Berrebi, P.

in Journal of Fish Biology (1994), 45

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See detailTests standardisés de routine pour l'évaluation de la condition physique chez les chevaux d'endurance
Noel de Burlin, A; Art, Tatiana ULg; Amory, Hélène ULg et al

in Pratique Vétérinaire Equine (1994), 26

The purpose of this study was to try to assess the fitness of endurance horses by using a simple routine standardized treadmill exercise test performed before and after a training period. Seven endurance ... [more ▼]

The purpose of this study was to try to assess the fitness of endurance horses by using a simple routine standardized treadmill exercise test performed before and after a training period. Seven endurance horses aged 7 to 13 years, unfamiliar with the treadmill conditions and competing in international championship were tested twice in an air-conditioned laboratory, i.e. before and after a 4-month training period. The test was preceded by a 20 min warm-7 period and consisted of 2 min walk and 2 min trot (4.2 m/sec) with a slope of 0, 2, 4, 6, 8 and 10 The whole test lasted 45 min. Venous blood was sampled before and 4 min after each test. Heart rate was continuously recorded before, during and after the test with a cardiometer. Rectal temperature, respiratory rate and body weight were measured before and after the test. The completion of the test induced a significant decrease of the body weight, a significant increase in packed cell volume, cortisol, white blood cells, proportion of granulocytes, lactate, free fat acids and iso-enzyme LDH 5, and no change in the ions and in the activity of the other enzymes. Training did not induce significant changes in blood parameters, except in hacked cell volume and cortisol. Training induced a significant decrease in heart rate at all exercise intensities and during recovery. It was concluded that the test proposed in this study is simple, safe, suitable for horses unfamiliar with the treadmill and applicable in a 1-day clinic routine examination. In these conditions, the most reliable parameter for the assessment of fitness in endurance horses seems to be the heart rate recorded during 2 standardized tests performed before and after a training period [less ▲]

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See detailFavoriser la reproduction des poissons à Lanaye.
Poncin, Pascal ULg; Keulen, C.

in Pêcheur Belge (Le) (1994), 6

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See detailLes souches attachantes et effaçantes d'Escherichia coli d'origine bovine
Mainil, Jacques ULg; Pohl, P.

in Annales de Médecine Vétérinaire (1994), 138

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See detailDistribution of POC, PON and particulate Al, Cd, Cr, Cu, Pb, Ti, Zn and deltaC13 in the English Channel and adjacent areas
Dauby, Patrick ULg; Frankignoulle, Michel; Gobert, Sylvie ULg et al

in Oceanologica Acta (1994), 17(6), 643-657

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See detailL'hyperthermie, une modalité oncologique pluridisciplinaire
Coucke, Philippe ULg; GUILLEMIN; RAIMONDI et al

in Médecine et Hygiène (1994), 52(2037), 1720-1722

L-hyperthermie consiste en l'élévation de la température du corps ou d'une de ses parties, par des moyens externes au-delà de 41°C. La chaleur a une activité cytotoxique propre et provoque une ... [more ▼]

L-hyperthermie consiste en l'élévation de la température du corps ou d'une de ses parties, par des moyens externes au-delà de 41°C. La chaleur a une activité cytotoxique propre et provoque une sensibilisation des cellules aux radiations ionisantes ou à la chimiothérapie. Le gain thérapeutique est environ de 2. Seules les tumeurs superficielles peuvent être traitées adéquatement par les moyens actuels. Les indications sont la palliation de tumeurs superficielles telles que les récidives loco-régionales du cancer du sein, les récidives ganglionnaires de cancers ORL et les cancers de la peau, en particulier les mélanomes [less ▲]

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See detailCLOE, A NEW RATE-TYPE CONSTITUTIVE MODEL FOR GEOMATERIALS THEORETICAL BASIS AND IMPLEMENTATION
CHAMBON, René; DESRUES, Jacques; HAMMAD, Wallid et al

in International Journal for Numerical and Analytical Methods in Geomechanics (1994), 18(4), 253-278

The paper describes the basic ideas and the main features of a new class of constitutive laws, in the framework of incrementally non-linear constitutive equations. CLoE is a generic name for that new ... [more ▼]

The paper describes the basic ideas and the main features of a new class of constitutive laws, in the framework of incrementally non-linear constitutive equations. CLoE is a generic name for that new class of laws, with reference to consistency at the limit surface, and explicit localization analysis. A top-down analysis of the model is presented, and illustrated by examples. [less ▲]

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See detailDu « bon usage » de la notion de syncrétisme
Pirenne-Delforge, Vinciane ULg; Motte, André ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1994), 7

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See detailLes dommages dus aux plans et leur indemnisation dans le cadre du CWATUP
Delnoy, Michel ULg

in Aménagement - Environnement (1994), 3

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See detailQuand la chimie s’en mêle
Flandroy, P; Grandfils, Christian ULg

in le Journal du Médecin (1994), 16

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See detailEvaluation of Matrix Metalloproteinases and Serine Proteases Activities in Three B16 Melanoma Cell Lines with Distinct Tumorigenic Potential
Baramova, E. N.; Coucke, P.; Leprince, Pierre ULg et al

in Anticancer Research (1994), 14(3A, May-Jun), 841-6

Mouse B16 melanoma cells (B16, parental line) and two derived clones either pigmented (B16P) or non pigmented (B16NP) were cultured as monolayers (2D) or on agar, as aggregates (3D). The productions of ... [more ▼]

Mouse B16 melanoma cells (B16, parental line) and two derived clones either pigmented (B16P) or non pigmented (B16NP) were cultured as monolayers (2D) or on agar, as aggregates (3D). The productions of gelatinases A and B (72 kDa and 92 kDa type IV collagenases) and their inhibitors (TIMP1 and TIMP2), plasminogen activators (PAs) and plasminogen activator inhibitors (PAI) were investigated. The B16 cell lines did not secrete any gelatinase, but they secreted TIMP2, tissue-type (t-PA), urokinase-type (u-PA) plasminogen activators and PAI-1 like activities. High levels of PAI activity were determined in conditioned media and cellular extracts of B16NP, which could account for the lower tumorigenic potential of these cells. In 3D cultures, the cellular extracts of the three cell lines contained essentially u-PA activity. This activity could contribute to the greater tumorigenic and invasive capacities of B16, B16P and B16NP when cultured in 3D. [less ▲]

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See detailDe l'utopie en architecture
Tieleman, David ULg

in A+ (1994)

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See detailNote sous l'arrêt de la CJCE du 19 janvier 1994, Eurocontrol
Partsch, Philippe-Emmanuel ULg

in Journal des Tribunaux Droit Européen (1994)

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See detailDe l'utopie en architecture. Une technique pour le Corbusier ?
Tieleman, David ULg

in Art&Fact (1994), 13

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See detailCLAY SUPPLIES IN THE CENTRAL INDIAN BASIN SINCE THE LATE MIOCENE - CLIMATIC OR TECTONIC CONTROL
Fagel, Nathalie ULg; DEBRABANT, P.; André, Luc

in Marine Geology (1994), 122(1-2), 151-172

Mineralogical (X-ray diffraction, differential thermal analysis), geochemical [microprobe, inductively coupled plasma (ICP)-atomic emission spectrometry, ICP-mass spectrometry] and Sr-Nd isotopic analyses ... [more ▼]

Mineralogical (X-ray diffraction, differential thermal analysis), geochemical [microprobe, inductively coupled plasma (ICP)-atomic emission spectrometry, ICP-mass spectrometry] and Sr-Nd isotopic analyses have been carried out on the clay size fraction of Late Miocene to Pleistocene sediments from the Central Indian Basin. The samples were taken from five giant cores recovered between 1-degree and 10-degrees-S on a transect along 80-degree-E. The clay assemblages are homogeneous and characterized by an alteration of illite- and smectite-rich levels. Most of the clays are detrital and were derived from a unique source: the weathering of the Indo-Gangetic Plain supplied most of the eroded material. Temporal clay mineralogical fluctuations in the depositional basin reflect environmental changes in the provenance. On the basis of spectral analyses of a mineralogical parameter (peak height ratios), the fluctuating smectite-illite clay sedimentation is controlled by periodic Late Miocene climatic changes. During the Late Pliocene, an irregular, probably tectonic, control appeared. [less ▲]

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See detailAn isozyme study in Bilberry (Vaccinium myrtillus ) 2. Mating system and genetic structure
Jacquemart, Anne Laure; Mahy, Grégory ULg; Raspé, Olivier et al

in Belgian Journal of Botany (1994), 127

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See detailAssignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4
Marine, Jean-Christophe; Bellefroid, Eric J.; Bourguignon, Catherine et al

in Genomics (1994), 21(1), 285-6

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See detailMicroencapsulation by coacervation of poly(lactide-co-glycolide): Physico-chemical characteristics of the phase separation process
Stassen, S; Nihant, Nicole; Martin, Véronique et al

in Polymer (1994), 35(4), 777-785

This paper describes the phase separation of different lactide and glycolide copolyester solutions, induced by the addition of silicone oil in order to promote protein microencapsulation. The phase ... [more ▼]

This paper describes the phase separation of different lactide and glycolide copolyester solutions, induced by the addition of silicone oil in order to promote protein microencapsulation. The phase diagrams of the ternary CH2Cl2-copolyester-silicone oil systems were established in relation to the composition of the copolyester and the viscosity, i.e. the molecular weight, of the silicone oil. The phase-separated systems were characterized in terms of weight, volume, composition and viscosity of the coacervation agent (silicone oil) on the characteristics of the phase-separated system is discussed. [less ▲]

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See detailLATTICE-DYNAMICS AND DIELECTRIC-PROPERTIES OF INCIPIENT FERROELECTRIC TIO2 RUTILE
LEE, C.; Ghosez, Philippe ULg; GONZE, X.

in Physical Review. B : Condensed Matter (1994), 50(18), 13379-13387

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See detailThiamine in Excitable Tissues: Reflections on a Non-Cofactor Role
Bettendorff, Lucien ULg

in Metabolic Brain Disease (1994), 9(3), 183-209

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See detailA comparative study of reporter gene activities in fish cells and embryos
Sekkali, B.; Hellemans, B.; Belayew, A. et al

in Molecular Marine Biology and Biotechnology (1994), 3

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See detailFollicular dendritic cells: whose children?
Heinen, Ernst ULg; Bosseloir, A.

in Immunology Today (1994), 15(5), 201-4

At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological ... [more ▼]

At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological conditions such as lymphoproliferative diseases and AIDS. Here, Ernst Heinen and Alain Bosseloir report on this fascinating field. [less ▲]

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See detailComparaison de l'évolution de 2 litières biomaîtrisées à base de sciure ou de paille pour porcs à l'engraissement
Marlier, Didier ULg; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1994), 138(1), 45-53

Two rooms of a pig house were used to study 2 deep litter systems where the animals were kept on a 50 cm thick layer of sawdust or of chopped straw (10 cm). Seven days before the arrival of the animals ... [more ▼]

Two rooms of a pig house were used to study 2 deep litter systems where the animals were kept on a 50 cm thick layer of sawdust or of chopped straw (10 cm). Seven days before the arrival of the animals, slurry and a microbial product used to stimulate the fermentation were added to the litters. Fifteen pigs on sawdust and seventien pigs on straw (floor spaces : 1.4 and 1.2 M2/pig) were fattened from 23.1 to 93.1 kg live weight. Excreta from pigs was dung into the bedding weekly and treated with the microbial product. This labour was considered as too hard in the straw room and was ended at day 105. No sawdust was added during the fattening period but straw was added 5 times to keep the pigs clean and to keep the temperature in the bedding higher than 30-degrees-C. The mean temperature in the sawdust bed was higher (38 +/- 5,4-degrees-C vs 35 +/- 6,7-degrees-C, p > 0,001) and more constant (mean daily variation 1,3 +/- 1,6 vs 2,2 +/- 2,4-degrees-C, p > 0,001) than the temperature recorded in the straw bed. The air temperature and the relative humidity were similar in the 2 rooms (21-degrees-C and 60 The concentrations of ammonia in the air were measured with Gastec tubes. The average ammonia concentrations recorded during the 7 days before the arrival of the animals (48 +/- 36 ppm vs 12 +/- 9,2 ppm) and those recorded after the eighth day (11 +/- 5,6 ppm vs 6,7 +/- 3,9 ppm) were significantly higher with the straw system compared with the sawdust system. The daily gains were not significantly different in the 2 rooms (552 g on average) and the food conversion ratios in the 2 rooms were 3,6 kg/kg (on sawdust) and 3,85 kg/kg (on straw). Carcasses were of equal quality. In conclusion, results were better with the sawdust bed than with the straw bed. The sawdust bed provided a higher temperature in the bedding and a lower ammonia concentration in the air. The routine weekly task of digging was easier in the sawdust bed and the bedding was used for a second batch. [less ▲]

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See detailModèles de cubage pour essences multi-tiges: application à des plantations d'acacia.
Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Cahiers Agricultures (1994), 3(3),

Des tarifs de cubage individuels ont été construits pour estimer le volume de plantations d'Acacia auriculiformis A. Cunn. ex Benth destinées à la production de bois de feu. Ces tarifs fournissent, d'une ... [more ▼]

Des tarifs de cubage individuels ont été construits pour estimer le volume de plantations d'Acacia auriculiformis A. Cunn. ex Benth destinées à la production de bois de feu. Ces tarifs fournissent, d'une part, le volume total incluant le bois de tiges et de branches jusqu'à une découpe de 9 cm de circonférence et, d'autre part, ce volume réparti en classes de circonférences de 9 à 14 cm, 15 à 44 cm et plus de 45 cm. Cette essence est généralement abondamment ramifiée, ce qui complique la détermination de son volume et interfère avec la caractérisation d'une variable dendrométrique déterminante, à savoir la circonférence ou le diamètre à 1,30m au-dessus du niveau du sol. Lorsque plusieurs tiges sont observées à 1,30m de hauteur, il est proposé de considérer une circonférence théorique résultant de la somme quadratique des circonférences des brins mesurés à ce niveau. Différentes équations de cubage mettant en oeuvre les circonférences à la base de l'arbre (niveau d'abattage) ou à 1,30m, ainsi que la hauteur totale, l'âge et le nombre de brins, sont proposées pour des plantations âgées de quelques dizaines de mois. En termes de compromis entre précision des estimations et coût des mesures, l'équation faisant intervenir la circonférence à 1,30m, l'âge et le nombre de brins s'est avérée la plus satisfaisante. En ce qui concerne les estimations de volume par assortiments, applicables à des plantations plus âgées, les équations ne faisant intervenir que la seule circonférence à 1,3m sont largement acceptables. [less ▲]

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See detailEpidural anesthesia impairs both central and peripheral thermoregulatory control during general anesthesia.
Joris, Jean ULg; Ozaki, Makoto; Sessler, Daniel I et al

in Anesthesiology (1994), 80(2), 268-77

BACKGROUND: The authors tested the hypotheses that: (1) the vasoconstriction threshold during combined epidural/general anesthesia is less than that during general anesthesia alone; and (2) after ... [more ▼]

BACKGROUND: The authors tested the hypotheses that: (1) the vasoconstriction threshold during combined epidural/general anesthesia is less than that during general anesthesia alone; and (2) after vasoconstriction, core cooling rates during combined epidural/general anesthesia are greater than those during general anesthesia alone. Vasoconstriction thresholds and heat balance were evaluated under controlled circumstances in volunteers, whereas the clinical importance of intraoperative thermoregulatory vasoconstriction was evaluated in patients. METHODS: Five volunteers were each evaluated twice. On one of the randomly ordered days, epidural anesthesia (approximately T9 dermatomal level) was induced and maintained with 2-chloroprocaine. On both study days, general anesthesia was induced and maintained with isoflurane (0.7% end-tidal concentration), and core hypothermia was induced by surface cooling and continued for at least 1 h after fingertip vasoconstriction was observed. Patients undergoing colorectal surgery were randomly assigned to combined epidural/enflurane anesthesia (n = 13) or enflurane alone (n = 13). In appropriate patients, epidural anesthesia was maintained by an infusion of bupivacaine. The core temperature that triggered fingertip vasoconstriction identified the threshold. RESULTS: In the volunteers, the vasoconstriction threshold was 36.0 +/- 0.2 degrees C during isoflurane anesthesia alone, but significantly less, 35.1 +/- 0.7 degrees C, during combined epidural/isoflurane anesthesia. Cutaneous heat loss and the rates of core cooling were similar 30 min before vasoconstriction with and without epidural anesthesia. In the 30 min after vasoconstriction, heat loss decreased 33 +/- 13 W when the volunteers were given isoflurane alone, but only 8 +/- 16 W during combined epidural/isoflurane anesthesia. Similarly, the core cooling rates in the 30 min after vasoconstriction were significantly greater during combined epidural/isoflurane anesthesia (0.8 +/- 0.2 degrees C/h) than during isoflurane alone (0.2 +/- 0.1 degrees C/h). In the patients, end-tidal enflurane concentrations were slightly, but significantly, less in the patients given combined epidural/enflurane anesthesia (0.6 +/- 0.2% vs. 0.8 +/- 0.2%). Nonetheless, the vasoconstriction threshold was 34.5 +/- 0.6 degrees C in the epidural/enflurane group, which was significantly less than that in the other patients, 35.6 +/- 0.8 degrees C. When the study ended after 3 h of anesthesia, patients given combined epidural/enflurane anesthesia were 1.2 degrees C more hypothermic than those given general anesthesia alone. The rate of core cooling during the last hour of the study was 0.4 +/- 0.2 degrees C/h during combined epidural/enflurane anesthesia, but only 0.1 +/- 0.3 degrees C/h during enflurane alone. CONCLUSIONS: These data indicate that epidural anesthesia reduces the vasoconstriction threshold during general anesthesia. Furthermore, the markedly reduced rate of core cooling during general anesthesia alone illustrates the importance of leg vasoconstriction in maintaining core temperature. [less ▲]

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See detailLes films Lumière : médiation symbolique et médiatisation
Servais, Christine ULg

in European Journal for Semiotic Studies = Revue Européenne d'Etudes Sémiotiques = Europäische Zeitschrift für Semiotische Studien (1994), 6(3-4), 505-538

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See detailVibration amplitudes caused by parametric excitation of cable stayed structures
Lilien, Jean-Louis ULg; Pinto da Costa, Antonio

in Journal of Sound & Vibration (1994), 174(N°1), 69-90

This paper deals with one kind of cable vibrations : the ones caused by parametric excitation.

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See detailDifferential diagnosis of Alzheimer's disease with PET.
Salmon, Eric ULg; Sadzot, Bernard ULg; Maquet, Pierre ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1994), 35(3), 391-8

PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias ... [more ▼]

PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias. METHODS: To evaluate the diagnostic power of cerebral metabolic distribution patterns for "cortical" degenerative dementias, PET scans obtained from 129 patients referred for differential diagnosis of dementia were analyzed visually. RESULTS: Sixty-five patients had a final clinical diagnosis of probable AD. Ninety-seven percent (97%) of those had abnormal metabolic scans and 94% showed a suggestive pattern of bilateral or unilateral temporo-parietal hypometabolism (with or without frontal involvement). Hypometabolism was unilateral in 23% of patients. Five subjects with a neuropathologically proven diagnosis of Alzheimer's disease had a suggestive metabolic pattern. One of those was an early case with frontal hypometabolism exceeding temporo-parietal involvement. Two patients with Alzheimer's-type dementia had isolated bilateral frontal hypometabolism. CONCLUSIONS: This alternative metabolic pattern may correspond to a non-Alzheimer pathology occurring in 10%-20% of patients suffering from clinically probable Alzheimer's disease. Most of the patients with possible but atypical Alzheimer's-type dementia showed isolated bilateral frontal involvement. This metabolic pattern probably corresponds to different diseases, such as Pick's disease, frontal lobe dementia or progressive subcortical gliosis. [less ▲]

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See detailPole, albedo and shape of the minor planets 624 Hektor and 43 Ariadne: Two tests for comparing four different pole determination methods
Detal, Alain ULg; Hainaut, O.; Pospieszalska-Surdej, A. et al

in Astronomy and Astrophysics (1994), 281

Asteroids 624 Hektor and 43 Ariadne have been observed photometrically at the European Southern Observatory (La Silla, Chile) in order to determine their pole orientation. The lightcurves (1984 and 1991 ... [more ▼]

Asteroids 624 Hektor and 43 Ariadne have been observed photometrically at the European Southern Observatory (La Silla, Chile) in order to determine their pole orientation. The lightcurves (1984 and 1991 oppositions for Hektor, and 1985 for Ariadne) are presented. Some of the traditional pole determination methods have been improved, and completely original ones have been developed. They are described and applied to the newly recorded and previously published light curves. The results are commented and compared with previous ones. In addition to the pole orientation, we also derive some information on the shape or the albedo distribtuion of the objects. With the aim of optimizing future observations of these asteroids, we present some graphs showing the best longitudes where they should be measured. Finally, we suggest some improvements in the pole determination and modeling methods based upon photometric data. [less ▲]

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See detailOù peut-on planter l’aulne glutineux avec succès ?
Claessens, Hugues ULg

in Silva Belgica (1994), 101

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See detailModular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM
Kishan, Radha; Zeelen, Ph. Johan; Noble, Martin E.M. et al

in Protein Engineering (1994), 7(8), 945-51

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha ... [more ▼]

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha-unit of E. coli TIM with the equivalent unit of chicken TIM. This replacement involves 10 sequence changes. One of the changes concerns the mutation of a buried alanine (Ala232 in strand 8) into a phenylalanine. The ETIM8CHI structure shows that the A232F sequence change can be incorporated by a side-chain rotation of Phe224 (in helix 7). No cavities or strained dihedrals are observed in ETIM8CHI in the region near position 232, which is in agreement with the observation that ETIM8CHI and E.coli TIM have similar stabilities. The largest CA (C-alpha atom) movements, approximately 3 A, are seen for the C-terminal end of helix 8 (associated with the outward rotation of Phe224) and for the residues in the loop after helix 1 (associated with sequence changes in helix 8). From the structure it is not clear why the kcat of ETIM8CHI is 10 times lower than in wild type E.coli TIM. [less ▲]

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See detailLe plan régional d'aménagement du territoire wallon
Delnoy, Michel ULg; Pâques, Michel ULg

in Aménagement - Environnement (1994), n° spécial

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See detailAspects épidémiologiques du suicide
Gosset, Christiane ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 2

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See detailLes Formations du Dévonien inférieur du Massif de la Vesdre, de la Fenêtre de Theux et du Synclinorium de Dinant (Belgique, France)
Godefroid, J; Blieck, A; Bultynck, P et al

in Memoirs of the Geological Survey of Belgium (1994), 38

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See detailSelective Antiprotozoal Activity of Some Strychnos Alkaloids
Wright, Colin; Allen, David; Cai, Ya et al

in Phytotherapy Research (1994), 8

The in vitro activities of 28 Strychnos alkaloids have been determined against three species of protozoa and the most active compounds were then assessed for in vitro cytotoxic activity against KB cells ... [more ▼]

The in vitro activities of 28 Strychnos alkaloids have been determined against three species of protozoa and the most active compounds were then assessed for in vitro cytotoxic activity against KB cells. 3',4'-dihydrousambarensine was the most active against Plasmodium falciparum and was relatively nontoxic to KB cells (cytotoxic/antiplasmodial ratio, 1474). Usambarensine displayed the most selectivity against Entamoeba histolytica while "',4'-dihydrousambarensine was the most selective compound against Giardia intestinalis although the cytotoxic/antiprotozoal ratios (20.4 and 6.6 respectively) were less favourable than the above.The four strychnobiline-type alkaloids were found devoid of activity against E. histolytica and G. intestinalis but to have weak antiplasmodial properties (7-13 times less active than chloroquine). None of the compounds containing only one indole ring system displayed antiprotozoal properties. [less ▲]

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See detailValeur semeiologique des examens de laboratoire: application multicentrique au depistage des metastases hepatiques.
Bourguignat, Alain; Albert, Adelin ULg; Dumont, Gilles et al

in Annales de Biologie Clinique (1994), 52(11), 787-97

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See detailSequence-Analysis Of A 40.2-Kb Dna Fragment Located Near The Left Telomere Of Yeast Chromosome-X
Vandenbol, Micheline ULg; Durand, Patrick; Bolle, P. A. et al

in Yeast (1994), 10(12),

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See detailMachine learning, neural networks and statistical pattern recognition for voltage security: a comparative study
Wehenkel, Louis ULg; Van Cutsem, Thierry ULg; Pavella, Mania ULg et al

in International Journal of Intelligent Systems (1994), 2

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See detailCrystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme
Mande, S. C.; Mainfroid, V.; Kalk, K. H. et al

in Protein Science : A Publication of the Protein Society (1994), 3(5), 810-21

The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement ... [more ▼]

The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement, the R-factor is 16.7% with good geometry. The asymmetric unit contains 1 complete dimer of 53,000 Da, with only 1 of the subunits binding the inhibitor. The so-called flexible loop, comprising residues 168-174, is in its "closed" conformation in the subunit that binds the inhibitor, and in the "open" conformation in the other subunit. The tips of the loop in these 2 conformations differ up to 7 A in position. The RMS difference between hTIM and the enzyme of Trypanosoma brucei, the causative agent of sleeping sickness, is 1.12 A for 487 C alpha positions with 53% sequence identity. Significant sequence differences between the human and parasite enzymes occur at about 13 A from the phosphate binding site. The chicken and human enzymes have an RMS difference of 0.69 A for 484 equivalent residues and about 90% sequence identity. Complementary mutations ensure a great similarity in the packing of side chains in the core of the beta-barrels of these 2 enzymes. Three point mutations in hTIM have been correlated with severe genetic disorders ranging from hemolytic disorder to neuromuscular impairment. Knowledge of the structure of the human enzyme provides insight into the probable effect of 2 of these mutations, Glu 104 to Asp and Phe 240 to Ile, on the enzyme. The third mutation reported to be responsible for a genetic disorder, Gly 122 to Arg, is however difficult to explain. This residue is far away from both catalytic centers in the dimer, as well as from the dimer interface, and seems unlikely to affect stability or activity. Inspection of the 3-dimensional structure of trypanosomal triosephosphate isomerase, which has a methionine at position 122, only increased the mystery of the effects of the Gly to Arg mutation in the human enzyme. [less ▲]

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See detailThe mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.
Wilkin, J M; Dubus, Alice ULg; Joris, Bernard ULg et al

in Biochemical Journal (1994), 301 ( Pt 2)

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the ... [more ▼]

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the active-site cavity. Thr299 corresponds to the second residue of the Lys-Thr(Ser)-Gly triad, highly conserved in active-site beta-lactamases and penicillin-binding proteins (PBPs). Modification of Thr301 resulted only in minor alterations of the catalytic and penicillin-binding properties of the enzyme. No selective decrease of the rate of acylation was observed for any particular class of compounds. By contrast, the loss of the hydroxy group of the residue in position 299 yielded a seriously impaired enzyme. The rates of inactivation by penicillins were decreased 30-50-fold, whereas the reactions with cephalosporins were even more affected. The efficiency of hydrolysis against the peptide substrate was also seriously decreased. More surprisingly, the mutant was completely unable to catalyse transpeptidation reactions. The conservation of an hydroxylated residue in this position in PBPs is thus easily explained by these results. [less ▲]

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See detailLa châsse de saint Remacle à Stavelot : étude des éléments décoratifs
Van den Bossche, Benoît ULg

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Beaux-Arts (1994), V(1-6), 109-149

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See detailAnomalie pluviométrique négative sur le Sud-est du Zaïre en janvier 1992
Kalombo, K.; Erpicum, Michel ULg; Lahuec, J. P.

in Publications de l'Association Internationale de Climatologie (1994), 7

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See detailOPTIMIZATION OF LIPASE-CATALYZED SYNTHESIS OF CITRONELLYL ACETATE IN SOLVENT-FREE MEDIUM
Fonteyn, Fabienne ULg; Blecker, Christophe ULg; Lognay, Georges ULg et al

in Biotechnology Letters (1994), 16(7), 693-696

Citronellol esterification catalyzed by Candida antarctica lipase is performed with high yields (74%) in a solvent-free medium. The use of dessicants gives a 10% yield enhancement and substrate excess ... [more ▼]

Citronellol esterification catalyzed by Candida antarctica lipase is performed with high yields (74%) in a solvent-free medium. The use of dessicants gives a 10% yield enhancement and substrate excess consumption by adding calculated amounts of acetic acid lead to a 80% pure citronellyl acetate. Quantities up to 100 ml are treated with success. [less ▲]

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See detailAspects redistributifs de l'endettement public
Pestieau, Pierre ULg; Perelman, Sergio ULg

in La dette publique en Belgique (1994)

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See detailMetalloproteinases and serine proteases activities in mixed spheroids of mouse B16 melanoma cells and fibroblasts
Coucke, Paul; Baramova, Eugenia; Leprince, Pierre ULg et al

in International Journal of Oncology (1994), 5

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See detailL'identité wallonne saisie par l'enquête : une approche constructiviste de l'identité collective
Jacquemain, Marc ULg; Vandekeere, Michel; Doutrelepont, René

in Res Publica (1994), 26

The paper shows how a constructivist approach of collective identity makes sense of the use of survey data to approach regional walloon identity

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See detailCoupling and carbonylation of iodoaromatics and terminal alkynes or alkynols catalyzed by a dimeric palladium hydroxide
Delaude, Lionel ULg; Masdeu, Anna M.; Alper, Howard

in Synthesis (1994), (11), 1149-1151

The palladium(II) complex [(Ph(3)P)Pd(Ph)mu-OH)](2) is an effective catalyst for the coupling and carbonylation of alkynes and iodoarenes to give acetylenic ketones in 63-94% yields. Acetylenic hydroxy ... [more ▼]

The palladium(II) complex [(Ph(3)P)Pd(Ph)mu-OH)](2) is an effective catalyst for the coupling and carbonylation of alkynes and iodoarenes to give acetylenic ketones in 63-94% yields. Acetylenic hydroxy ketones were formed using secondary or tertiary alkynols as reactants. [less ▲]

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See detail'Pattern' comportemental de type A : stress et maladie coronarienne : II. Aspects pratiques
Etienne, Anne-Marie ULg; Fontaine, Ovide ULg

in Revue Médicale de Liège (1994), XLIX(1), 36-48

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See detailOPTICAL MULTICHANNEL ANALYSIS OF PROTOCHLOROPHYLLIDE PHOTOTRANSFORMATION IN DETERGENT-SOLUBILIZED ETIOPLAST MEMBRANES OF WHEAT
Franck, Fabrice ULg; OUAZZANI, M. A.; DUJARDIN, E. et al

in Zeitschrift Fur Naturforschung C-A Journal Of Biosciences (1994), 49(1-2), 125-131

Extracts of wheat etioplast membranes obtained after treatment with 7 mM n-octyl-beta-D-glucopyranoside (OG), n-dodecyl-beta-D-maltoside (DM) or Triton X-100 contained the three spectral forms of Pchlide ... [more ▼]

Extracts of wheat etioplast membranes obtained after treatment with 7 mM n-octyl-beta-D-glucopyranoside (OG), n-dodecyl-beta-D-maltoside (DM) or Triton X-100 contained the three spectral forms of Pchlide (the photoactive Pchlide(638) and Pchlide(638) and the inactive Pchlide(650)) in various relative amounds. The OG extract had a Pchlide composition close to that of the intact membranes whereas the DM extract was enriched in Pchlide(638) and the Triton extract was enriched in Pchlide(630). Measurements of the kinetics of phototransformation and of time-resolved absorbance spectra during phototransformation in continuous Light shows that the inactive Pchlide(630) is in fact slowly transformed to Chlide, especially in the Triton extract where this form is more abundant. Addition of NADPH favours the phototransformation of Pchlide(630) and the slow regeneration of Pchlide(638) and Pchlide(650) from Pchlide(630) in darkness after illumination. No such regeneration was however observed in the Triton extract. NADPH had only slight effects on the Chlide shift towards shorter wavelengths after phototransformation in solubilized membranes. [less ▲]

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See detailTwo silencing sub-domains of v-erbA synergize with each other, but not with RXR.
Martin, Bernd; Renkawitz, Rainer; Muller, Marc ULg

in Nucleic Acids Research (1994), 22(23), 4898-905

The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) induce gene expression in the presence of specific ligand and repress transcription in the absence of hormone. This repression is ... [more ▼]

The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) induce gene expression in the presence of specific ligand and repress transcription in the absence of hormone. This repression is mediated by an active silencing mechanism rather then by interference with DNA binding activators. V-erbA, a variant form of TR which is unable to bind hormone, represents a constitutive repressor. Here we show, using fusion proteins with the GAL4 DNA binding domain, that the minimal silencing domain of v-erbA extends from amino acids 389 to 632 and that internal deletions within this domain retain at least some repression function. Co-transfection experiments of different deletion mutants indicate that the silencing domain is composed of at least two sub-domains which are non-functional when tested individually. When combined in a heterodimeric complex, they synergize such that silencing activity is regained. In contrast to the retinoic acid receptor the retinoid X receptor does not contain a silencing domain. In addition it is unable to cooperate with the repression function of TR or v-erbA in a heterodimer. [less ▲]

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See detailCaracteristiques des phosphatases acides de l'orge en condition de stress hydrique.
Ben-Naceur, M'B.; Paul, Roger ULg; Portetelle, Daniel ULg et al

in Cahiers Agricultures (1994), 3(4),

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See detailA new species of trametes from Papua New Guinea
Castillo Cabello, Gabriel ULg

in Mycotaxon (1994)

Trametes demoulinii from Papua New guinea is descrebed as new. The new taxon is closest to Trametes conchifer and Trametes membranacea, both from America and Trametes cingulata know in Africa and East ... [more ▼]

Trametes demoulinii from Papua New guinea is descrebed as new. The new taxon is closest to Trametes conchifer and Trametes membranacea, both from America and Trametes cingulata know in Africa and East Asia. In addition to basidiomata, cultural characters of the new species are described. [less ▲]

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See detailIndia Song ou le temps tragique
Badir, Sémir ULg

in Cinémas (1994), 5(1-2), 123-133

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See detailAutonomously functioning thyroid nodules in a patient with a thyrotropin-secreting pituitary adenoma: possible cause--effect relationship.
Abs, R.; Stevenaert, Achille ULg; Beckers, Albert ULg

in European Journal of Endocrinology (1994), 131(4), 355-8

A 51-year-old female patient with long-standing hyperthyroidism due to a thyrotropin-secreting pituitary adenoma is reported, who became thyrotoxic again shortly after successful pituitary surgery ... [more ▼]

A 51-year-old female patient with long-standing hyperthyroidism due to a thyrotropin-secreting pituitary adenoma is reported, who became thyrotoxic again shortly after successful pituitary surgery. Functional testing and scintigraphy suggested the diagnosis of autonomous functioning thyroid nodules, which was confirmed by pathological examination of the resected thyroid tissue. This is the first report revealing the transition from a pituitary-dependent to a thyroid-dependent hyperthyroidism. Autonomous functioning thyroid nodules are, however, considered an intrinsic thyroid defect. In similarity with other disorders, in which trophic hormones may induce an autonomous secretion by the target gland, this report opens the possibility that a humoral factor may play a role in the development of autonomous functioning thyroid nodules. [less ▲]

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See detailConfrontation anatomo-clinique: a propos de deux cas de meningite bacterienne.
Deprez, Manuel ULg; Van Den Brule, Justine ULg; Degauque, C. et al

in Revue Médicale de Liège (1994), 49(11), 615-20

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See detailLe prix de la vie: une approche ex post
Faudemer, S.; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Risques (1994), (19), 117-132

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See detailAttenuation Of Bovine Leukemia-Virus By Deletion Of R3 And G4 Open Reading Frames
Willems, Luc ULg; Kerkhofs, P.; Dequiedt, Franck ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1994), 91(24),

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See detailEssai sur le rythme statuaire à la période protohistorique en Mésopotamie
Tunca, Önhan ULg

in Beiträge zur Altorientalischen Archäologie und Altertumskunde (1994)

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See detailA complex composed of at least two HeLa nuclear proteins protects preferentially one DNA strand of the simple (gt)n(ga)m containing region of intron 2 in HLA-DRB genes.
Maueler, Winfried; Frank, G.; Muller, Marc ULg et al

in Journal of Cellular Biochemistry (1994), 56(1), 74-85

Electrophoretic mobility shift assays reveal that HeLa nuclear proteins bind fast and with measurable affinity to target DNAs containing mixed simple repetitive (gt)n(ga)m stretches. Preincubation of the ... [more ▼]

Electrophoretic mobility shift assays reveal that HeLa nuclear proteins bind fast and with measurable affinity to target DNAs containing mixed simple repetitive (gt)n(ga)m stretches. Preincubation of the proteins at elevated temperature prevents the formation of the major DNA/protein complex in favour of several distinct assemblies. A similar pattern of retarded bands was observed employing higher salt concentrations in the binding reaction. Thus conformational changes of different proteins appear to influence the complex rather than alternating DNA structures. Separation of the total nuclear extract into a water soluble and an insoluble protein fraction leads to a complete loss of target DNA binding capability of the fractions. The binding capacity is restored by combining the two fractions suggesting that at least two protein components are necessary to form a complex with the target sequence. The proteins can be differentiated into heat sensitive, water soluble and temperature stable, water insoluble, respectively. Furthermore, specifically binding polypeptides are not detectable by Southwestern analyses, probably because the essential components are separated during electrophoresis. DNase I footprint analyses yield four different protein binding regions only on the (gt)n(ga)m harbouring strand. The footprints cover larger portions of the mixed simple repeat in addition to a portion 5' of the (gt)n part. Hence at least two nuclear protein components of unknown biological function have to be present simultaneously to protect preferentially the (gt)n(ga)m-containing strand of intron 2 in HLA-DRB genes. [less ▲]

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See detailANOMALOUS PERTURBATIVE TRANSPORT IN TOKAMAKS DUE TO DRIFT-WAVE TURBULENCE
Thoul, Anne ULg; SIMILON, P. L.; SUDAN, R. N.

in Physics of Plasmas (1994), 1(3), 579-600

A new method for calculating the anomalous transport in tokamak plasmas is presented. The renormalized nonlinear plasma response function is derived using the direct-interaction approximation (DIA). A ... [more ▼]

A new method for calculating the anomalous transport in tokamak plasmas is presented. The renormalized nonlinear plasma response function is derived using the direct-interaction approximation (DIA). A complete calculation for the case of electrostatic drift-wave turbulence is presented. Explicit expressions for all coefficients of the anomalous transport matrix relating particle and heat fluxes to density and temperature gradients in the plasma are obtained. The anomalous transport matrix calculated using the DIA does not have the Onsager symmetry. As an example of application, the parameters of the Texas Experimental Tokamak (TEXT) [Nucl. Technol. Fusion 1, 479 (1981)] are used to evaluate all transport coefficients numerically, as well as the spectrum modulation. The relation between the theoretical results and the experimental data is discussed. Although this paper focuses on electron transport for simplicity, the method can also be used to calculate anomalous transport due to ion instabilities, such as the ion-temperature-gradient instability. [less ▲]

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See detailL'autisme et la pensée du temps
Gauthier, Jean-Marie ULg

in Recherches du centre international de psychosomatique (1994), 1

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See detailLe paradis d'une ville au siècle de Louis XIV
George, Philippe ULg

in Annales du Cercle Hutois des Sciences et Beaux-Arts (1994), XLVIII

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See detailParadoxe sur le philosophe (kant entre Bourdieu et Derrida)
Steinmetz, Rudy ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994)

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See detailAge-related differences in updating working memory
Van der Linden, Martial ULg; Brédart, Serge ULg; Beerten, A.

in British Journal of Psychology (1994), 85(1), 145-152

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See detailPhenotypic heterogeneity of the fibroblast-like cells in the dermis
Pierard-Franchimont, Claudine ULg; Fazaa, B.; Benzarti, H. et al

in Giornale Internazionale di Dermatologia Pediatrica (1994), 6(1), 7-13

The fibroblast-like cell population of the dermis is heterogeneous. The name "fibroblast" appears to be out-dated and should be replaced by terms reflecting with precision the immunophenotype of the cells ... [more ▼]

The fibroblast-like cell population of the dermis is heterogeneous. The name "fibroblast" appears to be out-dated and should be replaced by terms reflecting with precision the immunophenotype of the cells. Among them, dendrocytes type I (Factor XIIIa - positive) and dendrocytes type II (CD34 - positive) are involved in a wealth of pathologic conditions. [less ▲]

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See detailL'éthique en ses terres amères
Vrancken, Didier ULg

in Education Permanente (1994), 121

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See detailCircadian rhythms and the induction of flowering in the long-day grass Lolium temulentum L.
Périlleux, Claire ULg; Bernier, Georges ULg; Kinet, Jean Marie

in Plant, Cell & Environment (1994), 17(6), 755-761

Plants of Lolium temulentum L. strain Ceres were grown in 8-h short day (SD) for 45 d before being exposed either to a single long day (LD) or to a single 8-h SD given during an extended dark period. For ... [more ▼]

Plants of Lolium temulentum L. strain Ceres were grown in 8-h short day (SD) for 45 d before being exposed either to a single long day (LD) or to a single 8-h SD given during an extended dark period. For LD induction, the critical photoperiod was between 12 and 14 h, and more than 16 h were needed for a maximal flowering response. During exposure to a single 24-h LD, the translocation of the floral stimulus began between the fourteenth and the sixteenth hours after the start of the light period, and was completed by the twenty-fourth hour. Full flowering was also induced by one 8-h SD beginning 4 or 28 h after the start of a 40-h dark period, i.e. by shifting 12 h forward or beyond the usual SD. The effectiveness of a so-called 'displaced short day' (DSD) was not affected by light quality and light intensity. With a mixture of incandescent and fluorescent lights at a total photosynthetic photon flux density of 400 µmol m-2 s-1, a 4-h light exposure beginning 4 h after the start of a 40-h dark period was sufficient to induce 100 flowering. The flower-inducing effect of a single 8-h DSD was also assessed during a 64-h dark period. Results revealed two maxima at a 20-h interval. This fluctuation in light sensitivity suggests that a circadian rhythm is involved in the control of flowering of L. temulentum. [less ▲]

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See detailIncidence des aménagements hydrauliques sur le contrôle du développement de la bilharziose (shistosomiase)
Pliez, A.; Moens, R.; Debouche, Charles ULg

in Annales de Gembloux (1994), (100), 53-65

Le développement des irrigations dans les zones tropicales et subtropicales du monde, pour augmenter les productions de nourriture, a provoqué la prolifération de maladies liées à l'eau comme la ... [more ▼]

Le développement des irrigations dans les zones tropicales et subtropicales du monde, pour augmenter les productions de nourriture, a provoqué la prolifération de maladies liées à l'eau comme la bilharziose (également appelée shistosomiase), la dengue, la filariose et l'onchocercose. [less ▲]

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See detailTransient hypersensitivity to apomorphine-induced gnawing after termination of acute effects high dose of cocaine
Tirelli, Ezio ULg; Witkin, J. M.

in Behavioural Pharmacology (1994), 5(3), 289-298

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from ... [more ▼]

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from brain and the BEs of COC had dissipated (2 hrs and 4 hrs after administration), effects of AP on gnawing were increased 4-fold. This dopaminergic hypersensitivity (DA-H) was induced by acute treatment with doses of 15 mg/kg COC and higher. Effects of AP were not enhanced 6-24 hrs after COC, indicating a rapid waning of the DA-H. Hypersensitivity to AP (AP-H) was not further augmented by 8 days of daily COC injections. COC did not influence climbing and hypomotility induced by AP 4 hrs after its injection, demonstrating selectivity in the BEs of the DA-H. Further, COC did not induce sensitization to its own effects, indicating that the AP-H was not due to a typical sensitization phenomenon. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailIdentification Of Distinct Potyviruses In Mixedly-Infected Sweet-Potato By The Polymerase Chain-Reaction With Degenerate Primers
Colinet, D.; Kummert, J.; Lepoivre, Philippe ULg et al

in Phytopathology (1994), 84(1),

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See detailVaricelle létale. Etude immunohistochimique et par hybridation in situ
Nikkels, Arjen ULg; Delvenne, Philippe ULg; Sadzot-Delvaux, Catherine ULg et al

in Annales de Dermatologie et de Vénéréologie (1994), 121(2), 113-117

We report a case of lethal varicella developed in an immunocompromised man in his seventies. A study by immunohistochemistry and in situ hybridization was conducted revealing the presence of the ... [more ▼]

We report a case of lethal varicella developed in an immunocompromised man in his seventies. A study by immunohistochemistry and in situ hybridization was conducted revealing the presence of the glycoprotein gpI specific for VZV and its corresponding nucleic acids found in multiple foci of most tissues and organs, except in the brain and paravertebral sympathetic ganglia. [less ▲]

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See detailEtude du reservoir genetique de la legumineuse alimentaire Phaseolus lunatus L. par l'analyse electrophoretique d'isozymes.
Maquet, A.; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(3),

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See detailSpecific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.
Laptev, A. V.; Lu, Z.; Colige, Alain ULg et al

in Biochemistry (1994), 33(36), 11033-9

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system ... [more ▼]

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system consisted of mouse NIH 3T3 fibroblasts that were stably transfected with a human minigene for procollagen I so that the cells simultaneously synthesized full-length mouse pro alpha 1 (I) chains and internally deleted human pro alpha 1 (I) chains. The sequences of the transcripts from both genes were compared, and a series of 28 ASOs were designed to target sites in which there were at least two base differences within a 20-nucleotide sequence between the human and mouse transcripts. Six of the ASOs specifically decreased the levels of pro alpha 1 (I) chain synthesized from the human gene without a decrease in the levels of pro alpha 1 (I) chains from the mouse endogenous gene. The most effective ASOs reduced the intracellular levels of human pro alpha 1 (I) chains relative to the mouse pro alpha 1 (I) chains to 37-67% of the control values. Combined addition of two effective ASOs or a second administration of the same effective ASO did not produce any additive effect. The results did not support previous suggestions that the best target sites for ASOs were sequences around initiation codons for translation, at intron-exon boundaries, or in single-stranded loops in hairpin structures. Also, the results did not support previous suggestions that the most effective ASOs are those with the highest affinities for their target sequences. Instead, the most consistent pattern in the data was that the most effective ASOs were those targeted to sequences that were predicted to form clustered double-stranded structures in RNA transcripts. [less ▲]

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See detailSuccessful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC).
Snoeck, R.; Andrei, G.; Gerard, Marie-Christine ULg et al

in Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America (1994), 18(4), 570-8

The acyclic nucleoside phosphonate (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was used topically for the treatment of persistent mucocutaneous infections in two cases. One patient with ... [more ▼]

The acyclic nucleoside phosphonate (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was used topically for the treatment of persistent mucocutaneous infections in two cases. One patient with AIDS suffered from a perineal lesion due to infection with herpes simplex virus type 2 (HSV-2) and did not respond to acyclovir and was intolerant of foscarnet. A bone marrow transplant recipient developed orofacial lesions due to infection with herpes simplex virus type 1 (HSV-1) that failed to respond to therapy with both acyclovir and foscarnet. After topical application of HPMPC, the HSV-2 lesions completely resolved. However, the lesions recurred 3 weeks later, and, upon subsequent treatment with HPMPC, regressed. On recurrence, the virus was found to be sensitive to acyclovir, which the patient was given. Again HSV-2, which was resistant to acyclovir, emerged; similar observations were made after another cycle of HPMPC therapy. The HSV-1 isolates were resistant to acyclovir and foscarnet. Following local HPMPC treatment, the lesions regressed, but after 1 week, a second course of topical HPMPC therapy had to be instituted for recurrent infection. The lesions again regressed, and as the recurrent virus was sensitive to acyclovir, the patient was successfully treated with the drug. The results of this study point to the potential usefulness of topical HPMPC in the treatment of immunocompromised patients with HSV-related mucocutaneous infections that are refractory to therapy with acyclovir and/or foscarnet. [less ▲]

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See detailT-CELLS SKIN LYMPHOMA IN 3 DOGS
Gilbert, S.; Clercx, Cécile ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1994), 138(8), 587-595

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See detailA TEF-1 binding motif that interacts with a placental protein is important for the transcriptional activity of the hCS-B enhancer
Jacquemin, P.; Oury, Cécile ULg; Belayew, A. et al

in DNA & Cell Biology (1994), 13(10), 1037-45

The transcriptional activity of the human placental lactogen genes (choriosomatomammotropic hormone, hCS) is controlled by tissue-specific enhancers located 4 kb downstream from their respective origins ... [more ▼]

The transcriptional activity of the human placental lactogen genes (choriosomatomammotropic hormone, hCS) is controlled by tissue-specific enhancers located 4 kb downstream from their respective origins of transcription. The hCS-B enhancer is the strongest; its activity is mediated by synergism between two protein-binding sites (DF-3 and DF-4). The DF-4 site possesses a potential binding sequence for TEF-1, a known transcription factor. In this paper, we show by electrophoretic mobility-shift assays and antibody supershift experiments that TEF-1 does not bind to site DF-4. Mutations in the TEF-1-like binding motif of site DF-4 prevent formation of the DNA-protein complex, called complex f, in the presence of placental JEG-3 cell extracts. When HeLa cell extracts are used, another complex (complex c) is also affected. In transient expression experiments, TKCAT constructs linked to this mutated DF-4 site exhibit greatly reduced transcriptional activity when introduced into JEG-3 cells. Some cell lines contain both protein c and protein f (the proteins forming complexes c and f); when transfected, these lines display reduced DF-4-driven activity, suggesting that the two proteins could compete for the same DF-4 sequence. We conclude that protein f is important for the placenta-specific activity of the hCS-B enhancer. By UV cross-linking, we show that protein f is actually three polypeptides ranging in size from about 12 to 21 kD. [less ▲]

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See detailPreservation of Oocyte and Granulosa Cell Morphology in Bovine Preantral Follicles Cultured in Vitro
Figueiredo, J. R.; Hulshof, S. C.; Van den Hurk, R. et al

in Theriogenology (1994), 41(6), 1333-46

Described in the present paper is a culture system that preserves oocyte and granulosa cell morphology in bovine preantral follicles during 5 d in vitro. The effects of additional hypoxanthine and energy ... [more ▼]

Described in the present paper is a culture system that preserves oocyte and granulosa cell morphology in bovine preantral follicles during 5 d in vitro. The effects of additional hypoxanthine and energy substrata (i.e., pyruvate and glutamine) on the morphology of cultured preantral follicles were investigated. It was shown that addition of a mixture of pyruvate, glutamine and hypoxantine to the culture medium increased the percentage of follicles with an intact oocyte from 29.4 to 78.6%. Morphological criteria are described to discriminate between normal and degenerated preantral follicles during culture by inverted microscopy. In addition, the importance of histological evaluation to judge the quality of oocyte and granulosa cells is demonstrated. [less ▲]

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See detailQuantitative and qualitative study of the production of broad-spectrum antifungal lipopeptides from Bacillus subtilis S499.
Jacques, Ph.; Hbid, Ch.; Vanhentenryck, F. et al

in Progress in biotechnology (1994), 9

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See detail2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle; Dive, Georges ULg; Delaude, Clément et al

in Phytochemistry (1994), 35(2), 533-536

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based ... [more ▼]

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests. [less ▲]

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See detailEffect of selenium compounds on murine B16 melanoma cells and pigmented cloned pB16 cells
Siwek, Brigitte; Bahbouth, E.; Serra, M. A. et al

in Archives of Toxicology (1994), 68(4), 246-254

Seleno-DL-cysteine and sodium selenate are toxic in B16 cells and this toxicity seems to involve glutathione metabolites.

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See detailCompte-rendu de l'ouvrage de Chester G. Starr : The Aristocratic Temper of Greek Civilization
Vanhaegendoren, Koen ULg

in Etudes Classiques (1994), 62(1), 92

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See detailTypage moléculaire de Clostridium perfringers.
Daube, Georges ULg; Simon, P.; Limbourg, B. et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailApports et limites de trois approches courantes des associations
Defourny, Jacques ULg

in Coopératives et Développement (1994), 26(1), 81-101

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See detailMBO en Aandeelhouder
Corhay, Albert ULg; Herst, Arthur; Tourani Rad, Alireza

in Bedrifskunde (1994), 4

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See detailL'inventaire forestier régional wallon: brève présentation méthodologique.
Lecomte, H.; Rondeux, Jacques ULg

in Silva Belgica (1994), 101(6), 9-16

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie ... [more ▼]

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie [RONDEUX et al., 1984]. Cet inventaire s’appuyant sur un échantillonnage systématique simple était destiné à fournir un état des lieux de la forêt wallonne de l’époque ; il a notamment permis de confirmer ou de mettre en évidence plusieurs éléments essentiels pour l’avenir du patrimoine forestier wallon [RONDEUX et al., 1986] : - le vieillissement de la hêtraie ardennaise ; - l’importante disponibilité en bois d’épicéa ; - les écarts entre les surfaces forestières observées et celles du recensement officiel. Depuis la fin de cet inventaire en 1984, aucune mise à jour n’a été programmée et en conséquence, ses résultats ont perdu leur fiabilité notamment en raison des accidents météorologiques de la dernière décennie. En 1988, l’Exécutif de la Région Wallonne, conscient de l’importance de la forêt en tant que première ressource naturelle renouvelable de la Wallonie, a sollicité la Faculté des Sciences agronomiques de Gembloux en vue de finaliser une recherche destinée à concevoir une méthodologie d’inventaire forestier permanent. Les conclusions de cette étude ont été déposées fin 1993 [LECOMTE, 1994], ce qui a permis de lancer dès février 1994 la phase opérationnelle du premier inventaire forestier permanent pour la Wallonie. Dans les lignes qui suivent, nous aborderons successivement les objectifs de l’inventaire (paragraphe 2) ainsi que les principes généraux qui le régissent (paragraphe 3). Le cheminement de l’information sera décrit depuis la récolte des données (paragraphe 4) jusqu’à la publication des résultats (paragraphe 7) en passant par le traitement et l’exploitation des données (paragraphes 5 et 6). En guise de conclusions, nous émettrons quelques réflexions issues de notre propre expérience (paragraphe 8). [less ▲]

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See detailComment évaluer la sensibilité à l'insuline en pratique?
Scheen, A. J.; Paquot, Nicolas ULg; Letiexhe, M. R. et al

in Diabète & Métabolisme (1994), 20(6, Nov-Dec), 556-61

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See detailMeasurement of insulin sensitivity by the minimal model method using a simplified intravenous glucose tolerance test: validity and reproducibility.
Duysinx, Bernard ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Diabète & Métabolisme (1994), 20(4), 425-32

This study aimed at testing whether 12 rather than 26 plasma glucose and insulin determinations can be used to calculate the indices of insulin sensitivity and of glucose effectiveness using Bergman's ... [more ▼]

This study aimed at testing whether 12 rather than 26 plasma glucose and insulin determinations can be used to calculate the indices of insulin sensitivity and of glucose effectiveness using Bergman's minimal model during a simple intravenous glucose tolerance test performed without tolbutamide injection. Two intravenous glucose tolerance tests (separated by 1 week) were performed in 7 lean normal subjects and a single test was performed in 9 severely obese non-diabetic subjects. Intra-subject reproducibility of insulin sensitivity was not significantly different when 26 or 12 time-points were analyzed (CV = 16.8 +/- 3.4 versus 18.9 +/- 3.8% respectively). Compared with the insulin sensitivity of the lean subjects, that of obese subjects was significantly (P < 0.001) and similarly reduced when using 12 (2.14 +/- 0.34 versus 7.97 +/- 1.29 10(-4)min-1/mU.1-1) rather than 26 determinations (2.13 +/- 0.42 versus 6.95 +/- 1.12 10(-4) min-1/mU.1-1) respectively. Glucose effectiveness was less reproducible than insulin sensitivity and was slightly diminished by the reduction of blood samples (relative error: -9.7 +/- 4.4%; P < 0.05). Finally, glucose effectiveness tended to be slightly lower in the morbidly obese subjects than in the lean controls with both modes of calculation. In conclusion, in non-diabetic subjects, the insulin sensitivity index can be accurately measured during a simple intravenous glucose tolerance test, without tolbutamide injection and with only 12 blood samples. The possibility of performing a simplified test should contribute to increase the use of the minimal model method for estimating insulin sensitivity in clinical practice. [less ▲]

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See detailStructural and functional features of bovine leukemia virus gp51 head domain. Towards a general model for oncovirus envelope glycoproteins.
Callebaut, Isabelle; Portetelle, Daniel ULg; Burny, Arsène et al

in European Journal of Biochemistry (1994), 222(2), 405-414

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See detailInvolvement Of The Cyclic Amp-Responsive Element-Binding Protein In Bovine Leukemia-Virus Expression In-Vivo
Adam, E.; Kerkhofs, P.; Mammerickx, M. et al

in Journal of Virology (1994), 68(9),

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See detailLogiciel d'aide à la détermination détaillée du poids et du bilan électrique d'un navire
Marchal, Jean ULg; Hage, André ULg; Rodriguez, S.

in Bulletin de l'Association Technique Maritime et Aéronautique (1994)

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See detailLa rentabilité de l'activité hélicicole
Lebailly, Philippe ULg

in Agricontact (1994), (259 (mars)), 11-16

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