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See detailEfficient Implicit Schemes for Finite Element Impact Simulation
Ponthot, Jean-Philippe ULg; Graillet, D.

in International Journal of Crashworthiness (1999), 4(3), 273-285

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See detailUDP-N-Acetyl-alpha-D-glucosamine as acceptor substrate of beta-1,4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine.
Elling, Lothar; Zervosen, Astrid ULg; Gallego, Ricardo Gallego et al

in Glycoconjugate Journal (1999), 16(7), 327-36

The capacity of UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor substrate for beta-1,4-galactosyltransferase (beta4GalT1, EC 2.4.1.38) from human and bovine milk and for recombinant ... [more ▼]

The capacity of UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor substrate for beta-1,4-galactosyltransferase (beta4GalT1, EC 2.4.1.38) from human and bovine milk and for recombinant human beta4GalT1, expressed in Saccharomyces cerevisiae, was evaluated. It turned out that each of the enzymes is capable to transfer Gal from UDP-alpha-D-galactose (UDP-Gal) to UDP-GlcNAc, affording Gal(beta1-4)GlcNAc(alpha1-UDP (UDP-LacNAc). Using beta4GalT1 from human milk, a preparative enzymatic synthesis of UDP-LacNAc was carried out, and the product was characterized by fast-atom bombardment mass spectrometry and 1H and 13C NMR spectroscopy. Studies with all three beta4GalTs in the presence of alpha-lactalbumin showed that the UDP-LacNAc synthesis is inhibited and that UDP-alpha-D-glucose is not an acceptor substrate. This is the first reported synthesis of a nucleotide-activated disaccharide, employing a Leloir glycosyltransferase with a nucleotide-activated monosaccharide as acceptor substrate. Interestingly, in these studies beta4GalT1 accepts an alpha-glycosidated GlcNAc derivative. The results imply that beta4GalT1 may be responsible for the biosynthesis of UDP-LacNAc, previously isolated from human milk. [less ▲]

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See detailL'obesite feminine: souci esthetique ou probleme medical?
Luyckx, Françoise ULg; Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (1999), 54(4), 262-7

Women more and more frequently refer to medical doctors for treating weight excess. Even if the primum movens is usually a pure esthetic concern, medical aspects should not be neglected. Indeed, if ... [more ▼]

Women more and more frequently refer to medical doctors for treating weight excess. Even if the primum movens is usually a pure esthetic concern, medical aspects should not be neglected. Indeed, if obesity with gynoid adipose tissue distribution is less deleterious than android obesity from a metabolic point of view, severe obesity is frequently associated with cardiovascular risk factors which may hinder the prognosis of these female patients. Other complications are common in obese women, such as oestrogen-related cancers, osteoarticular problems and psychological disturbances. Various therapeutic approaches are available which permit an encouraging weight loss and a rapid improvement of risk factors. Unfortunately, long-term results are often disappointing, essentially because of the difficulty to follow on the long term a strict diet regimen and practice physical exercise and because of the usual unrealistic expectations of the obese women who consult medical doctors. [less ▲]

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See detailOncologie gastro-intestinale
Coucke, Philippe ULg; FREI; FELLEY et al

in Médecine et Hygiène (1999), 57(2240), 213-217

Même si aucune acquisition nouvelle n'est venue embaumer l'atmosphère encore trop souvent grisâtre de l'oncologie gastro-intestinale en 1998, la nécessité d'un consilium préthérapeutique associant ... [more ▼]

Même si aucune acquisition nouvelle n'est venue embaumer l'atmosphère encore trop souvent grisâtre de l'oncologie gastro-intestinale en 1998, la nécessité d'un consilium préthérapeutique associant chirurgiens, endoscopeurs, oncologues et radio-oncologues s'impose avec encore plus de fermeté, pour tous les cancers digestifs. Les patients devraient autant que possible être inclus dans des protocoles d'études bien conduits et bénéficier d'une chirurgie oncologique optimale. [less ▲]

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See detailMalathion Resistance Increases Male Reproductive Success In Tribolium Castaneum (Coleoptera : Tenebrionidae)
Arnaud, L.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Annales de la Societe Entomologique de France (1999), 35

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See detailAn MRI study of the effect of treadmill training on bone morphology of the central and third tarsal bones of young Thoroughbred horses
Whitton, R. C.; Murray, R. C.; Buckley, C. et al

in Equine Veterinary Journal. Supplement (1999), 30

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to ... [more ▼]

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to determine whether training influenced modelling of the third and central tarsal bones in Thoroughbred horses. Twelve untrained Thoroughbred horses were divided into 2 groups. Group 1 underwent a 19 week progressive training regimen on a high speed treadmill. Group 2 were walked for 40 min daily. Images of left tarsi were obtained by magnetic resonance imaging (MRI) with a 0.5 Tesla superconducting magnet using a spin echo sequence. Sagittal and oblique sagittal slices were made perpendicular to the articular surfaces of the intertarsal joints and were analysed using image analysis software to measure the proportion of dense subchondral bone in the dorsal facet of each bone. Mean +/- s.d. percentage area of dense subchondral bone in the dorsal facet of the central tarsal bone in Group 1 was 47 +/- 8 medially, 46 +/- 4 sagitally and 50 +/- 11 dorsolaterally, whereas in Group 2 it was 39 +/- 16 medially, 43 +/- 8 sagitally and 53 +/- 7 dorsolaterally. For the third tarsal bone mean +/- s.d. percentage area of dense subchondral bone in Group 1 was 32 +/- 10 medially, 39 +/- 11 sagitally and 44 +/- 8 dorsolaterally, whereas in Group 2 it was 28 +/- 8 medially, 37 +/- 6 sagitally and 41 +/- 9 dorsolaterally. There was no significant difference in percentage area of dense subchondral bone between the trained and untrained horses. An effect of treadmill training of Thoroughbred horses on modelling of the central and third tarsal bones could not be demonstrated. [less ▲]

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See detailDescription de trois cas autochtones de babésiose canine (Babesia canis) en Belgique
Losson, Bertrand ULg; Mollet, J. J.; Avez, F. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailOn-line Cough Recognizer System
Van Hirtum, Annemie; Aerts, Jean-Marie; Berckmans, Daniel et al

in Journal of the Acoustical Society of America (1999), 106(4:2), 2191

Until now the intelligent, controlled, and automated use of acoustic bio-responses in cattle houses as indicators of animal condition has been limited to human perception. Although the appearance of ... [more ▼]

Until now the intelligent, controlled, and automated use of acoustic bio-responses in cattle houses as indicators of animal condition has been limited to human perception. Although the appearance of coughing, sneezing, etc., may point to an environmental deficiency in the animal habitat or the presence of diseases amoung the cattle, in order to use this kind of acoustic information as a bio-response signal in practice it is necessary to develop a simple on-line algorithm. In this paper an on-line registration technique for pig coughing is presented. The application of a distance function to a spectral sound analysis allows us to distinguish coughing from other animal and environmental sounds like metal clanging, grunting, noise, etc. The sound database was collected on a group of six healthy animals [less ▲]

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See detailThe Structural And Functional Organization Of H-Ns-Like Proteins Is Evolutionarily Conserved In Gram-Negative Bacteria
Bertin, P.; Benhabiles, N.; Krin, E. et al

in Molecular Microbiology (1999), 31(1), 319-29

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi ... [more ▼]

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi and Haemophilus influenzae. Isolated outside these groups, the BpH3 protein of Bordetella pertussis exhibits a low amino acid conservation with H-NS, particularly in the N-terminal domain. To obtain information on the structure, function and/or evolution of H-NS, we searched for other H-NS-related proteins in the latest databases. We found that HvrA, a trans-activator protein in Rhodobacter capsulatus, has a low but significant similarity with H-NS and H-NS-like proteins. This Gram-negative bacterium is phylogenetically distant from Escherichia coli. Using theoretical analysis (e.g. secondary structure prediction and DNA binding domain modelling) of the amino acid sequence of H-NS, StpA (an H-NS-like protein in E. coli), BpH3 and HvrA and by in vivo and in vitro experiments (e.g. complementation of various H-NS-related phenotypes and competitive gel shift assay), we present evidence that these proteins belong to the same class of DNA binding proteins. In silico analysis suggests that this family also includes SPB in R. sphaeroides, XrvA in Xanthomonas oryzae and VicH in Vibrio cholerae. These results demonstrate that proteins structurally and functionally related to H-NS are widespread in Gram-negative bacteria. [less ▲]

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See detailPsychology facing the challenges of the third millenium
Richelle, Marc ULg

in Revista Portuguesa de Psicologia (1999), 33

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See detailL'etude clinique du mois. Interet d'augmenter un taux de cholesterol HDL bas en prevention secondaire de la coronaropathie: resultats de l'etude VA-HIT.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(9), 773-5

The "Veterans Affairs Cooperative Studies Program High-Density Lipoprotein Cholesterol Intervention Trial" (VA-HIT) is a large randomised, double-blind, placebo-controlled clinical trial for the secondary ... [more ▼]

The "Veterans Affairs Cooperative Studies Program High-Density Lipoprotein Cholesterol Intervention Trial" (VA-HIT) is a large randomised, double-blind, placebo-controlled clinical trial for the secondary prevention of coronary heart disease. It demonstrates that a fibrate treatment (gemfibrozil) significantly reduces the relative risk of major coronary (-22%, p = 0.006) and cardiovascular (-24%, p < 0.001) events in men with coronary heart disease whose primary lipid abnormality is a low HDL cholesterol level. These findings suggest that, in such a population, the rate of coronary events is reduced under gemfibrozil therapy by raising HDL cholesterol levels (+6%) and lowering levels of triglycerides (-31%) without lowering LDL cholesterol concentrations. [less ▲]

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See detailA propos des qualificatifs complet, orthogonal et équilibré en analyse de la variance.
Iemma, A. F.; Claustriaux, Jean-Jacques ULg

in Notes de Statistique et d'Informatique (1999), (2), 15

With examples, we introduce the words complete, orhtogonal and balanced used in analysis of variance.

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See detailEvaluation of implantation procedures for PIT tagging juvenile Nile tilapia
Baras, E.; Westerloppe, L.; Mélard, Charles ULg et al

in North American Journal of Aquaculture (1999), 61

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See detailCompte rendu de J. VERGER, La renaissance du XIIe siècle
George, Philippe ULg

in Moyen Age (Le) (1999)

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See detailEvaluation du système de financement des journées hospitalières en fonction des pathologies
Fecher-Bourgeois, Fabienne ULg; Gillet, Pierre ULg

in Bulletin des Résumés d'Informations Hospitalières / Ministère des affaires sociales, de la santé publique et de l'environnement (1999), 16(Janvier/février/mars 1999),

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See detailUltrastructural methods for nucleic acid detection by immunocytology.
Thiry, Marc ULg

in Progress in Histochemistry and Cytochemistry (1999), 34(2), 87-159

In the present review are summarized recent developments in immunocytochemical detection of nucleic acids in biological materials at the ultrastructural level. Not only the approaches using antibodies to ... [more ▼]

In the present review are summarized recent developments in immunocytochemical detection of nucleic acids in biological materials at the ultrastructural level. Not only the approaches using antibodies to natural nucleic acids are described but also the techniques involving the use of antibodies raised against various nucleotide analogs incorporated beforehand into nucleic acids. Special emphasis is placed on each method's potential and limitations. These methods, combined or not with molecular biotechnology, are powerful tools for studying the structure and function of nucleic acids. They can be used to investigate the distribution and topological organization of DNA and RNA molecules or of specialized within these molecules in the cells. [less ▲]

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See detailNegative magnetoresistance in mixed-valence La0.6Y0.1Ca0.3MnO3: Evidence for charge localization governed by the Curie-Weiss law
Sergeenkov, S.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in JETP Letters (1999), 70(2), 141-146

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss ... [more ▼]

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss-dominated transport mechanism in this material both above and below the field-dependent Curie temperature T(C)equivalent to T-0. Attributing this symmetry to strong magnetic fluctuations below T-C (which are triggered by the Y substitution and cause a "bootstrap" destruction of the ferromagnetic phase), the data are interpreted in terms of the nonthermal spin hopping and magnetization-dependent charge carrier localization scenario leading to Delta rho=-rho(s)(1-e(-gamma M2)), with the magnetization M(T,B)=CB/\ T-T-C(B)\(nu). The separate fits through all the data points above and below T-C yield C(+)similar or equal to 2C(-) and nu(+)similar or equal to nu(-)similar or equal to 1, in agreement with the predictions of the Landau mean-field theory. (C) 1999 American Institute of Physics. [S0021-3640(99)01314-6]. [less ▲]

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See detailFine-Mapping of Quantitative Trait Loci by Identity by Descent in Outbred Populations: Application to Milk Production in Dairy Cattle
Riquet, J.; Coppieters, Wouter ULg; Cambisano, Nadine ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1999), 96(16), 9252-9257

We previously mapped a quantitative trait locus (QTL) affecting milk production to bovine chromosome 14. To refine the map position of this QTL, we have increased the density of the genetic map of ... [more ▼]

We previously mapped a quantitative trait locus (QTL) affecting milk production to bovine chromosome 14. To refine the map position of this QTL, we have increased the density of the genetic map of BTA14q11-16 by addition of nine microsatellites and three single nucleotide polymorphisms. Fine-mapping of the QTL was accomplished by a two-tiered approach. In the first phase, we identified seven sires heterozygous "Qq" for the QTL by marker-assisted segregation analysis in a Holstein-Friesian pedigree comprising 1,158 individuals. In a second phase, we genotyped the seven selected sires for the newly developed high-density marker map and searched for a shared haplotype flanking an hypothetical, identical-by-descent QTL allele with large substitution effect. The seven chromosomes increasing milk fat percentage were indeed shown to carry a common chromosome segment with an estimated size of 5 cM predicted to contain the studied QTL. The same haplotype was shown to be associated with increased fat percentage in the general population as well, providing additional support in favor of the location of the QTL within the corresponding interval. [less ▲]

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See detailEtude des hypothèses de l'analyse de la variance à deux critères de classification : approche par l'exemple
Iemma, A. F.; Claustriaux, Jean-Jacques ULg

in Notes de Statistique et d'Informatique (1999), (3), 36

By examples and results from SAS and Minitab softwares (GLM), analysis of variance hypothesis built to analyse a two dimensional data table are introduced.

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See detailContribution of the carbohydrate moiety to conformational stability of the carboxypeptidase Y high pressure study.
Dumoulin, Mireille ULg; Ueno, H.; Hayashi, R. et al

in European Journal of Biochemistry (1999), 262(2), 475-83

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the ... [more ▼]

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the catalytic activity and, the intrinsic and 8-anilino-1-naphthalene sulfonic acid binding fluorescences. Pressure-induced denaturation of carboxypeptidase Y is a process involving at least three transitions. Low pressures (below 150 MPa) induced slight conformational changes characterized by a slight decrease in the center of the spectral mass of intrinsic fluorescence, whereas no changes in 8-anilino-1-naphthalene sulfonic acid binding fluorescence were observed and 80% of the catalytic activity remained. Higher pressure (150-500 MPa) induced further conformational changes, characterized by a large decrease in the center of the spectral mass of intrinsic fluorescence, a large increase in the 8-anilino-1-naphthalene sulfonic acid binding fluorescence and the loss of all catalytic activity. Thus, this intermediate exhibited characteristics of molten globule-like state. A further increase, in pressure (above 550 MPa) induced transition from this first molten globule-like state to a second molten globule-like state. This two-stage denaturation process can be explained by assuming the existence of two independent structural domains in the carboxypeptidase molecule. A similar three-transition process was found for unglycosylated carboxypeptidase Y, but, the first two transitions clearly occurred at lower pressures than those for glycosylated carboxypeptidase Y. These findings indicate that the carbohydrate moiety protects carboxypeptidase Y against pressure-induced denaturation. The origin of the protective effects is discussed based on the known crystallographic structure of CPY. [less ▲]

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See detailLa gestion forestière durable en Région wallonne : L'apport de l'inventaire permanent - Partie 2 : Intégration des indicateurs à l'inventaire
Lecomte, Hugues; Koestel, G.; Rondeux, Jacques ULg

in Silva Belgica (1999), 106(2), 7-14

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau ... [more ▼]

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau régional, un inventaire forestier permanent peut, outre les variables et paramètres qu'il traite habituellement, prendre en charge ces indicateurs. Moyennant quelques ajustements méthodologiques, il s'est avéré dans le cas de la Région wallonne, que l'Inventaire des Ressources ligneuses pouvait, grâce aux techniques d'échantillonnage qu'il met en oeuvre, constituer un outil pertinent pour dresser un état des lieux du développement durable en milieu forestier. En outre, du fait de son caractère permanent, il permet d'assurer le suivi de l'évolution des critères et indicateurs au cours du temps. Nous rappellerons très brièvement les bases méthodologiques de l'inventaire forestier régional (paragraphe 2) et les résultats de l'étude qui était destinée à lui faire prendre en compte des indicateurs de gestion durable (paragraphe 3). Nous nous attacherons à montrer comment ces indicateurs sont concrètement, selon les cas, observés, mesurés, calculés et traités (paragraphe 4), puis nous tirerons les quelques conclusions qui paraissent s'imposer (paragraphe 5). [less ▲]

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See detailTraitement antimigraineux: présent et avenir
Schoenen, Jean ULg

in Revue Médicale de Liège (1999), 54(2), 79-86

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See detailAnalysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.
Wang, Xingjun ULg; Tromp, G.; Cole, C. W. et al

in Matrix Biology (1999), 18(2), 121-4

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of ... [more ▼]

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of tissue remodeling are therefore candidate genes. We analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms (AAA), one individual with AAA and intracranial aneurysms (IA), four individuals with IA and two clinically unaffected individuals. We identified two nucleotide variants in both the TIMP1 and the TIMP2 coding sequences. All differences occurred in the third base positions of codons and were neutral polymorphisms. A significant difference was observed in the frequency of TIMP2 nt 573 polymorphism between 168 alleles from AAA patients and 102 control alleles. [less ▲]

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See detailSpreadsheet based teaching aids in chemical engineering education
Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Computers & Chemical Engineering (1999), 23(Suppl. S), 629-632

Modern spreadsheet programs offer a wide range of calculation, charting and dialog options, allowing the development of effective teaching aids. Examples of worksheet illustrating numerical analysis ... [more ▼]

Modern spreadsheet programs offer a wide range of calculation, charting and dialog options, allowing the development of effective teaching aids. Examples of worksheet illustrating numerical analysis, thermodynamics and unit operations are shown. All offer complete interaction between the problem statement and the presentation of results. [less ▲]

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See detailPlants associated with Tentaculites in a new Early Devonian locality from Morocco.
Gerrienne, Philippe ULg; Fairon-Demaret, Muriel ULg; Galtier, J et al

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailChanges in endothermic transitions associated with light-induced chlorophyllide formation, as investigated by differential scanning calorimetry
Mysliwa-Kurdziel, B.; Franck, Fabrice ULg; Chahdi, M. A. O. et al

in Physiologia Plantarum (1999), 107(2), 230-239

The changes in thermal transitions associated with protochlorophyllide (Pchlide) into chlorophyllide (Chlide) phototransformation were investigated using sensitive differential scanning calorimetry (DSC ... [more ▼]

The changes in thermal transitions associated with protochlorophyllide (Pchlide) into chlorophyllide (Chlide) phototransformation were investigated using sensitive differential scanning calorimetry (DSC), Two groups of endothermic transitions, each composed of several components, were observed between 25 and 90 degrees C for prolamellar body (PLB) membranes isolated from etiolated wheat (Triticum aestivum) leaves. The first group, located in the 20-45 degrees C region, was strongly affected by a short light pulse given prior to measurement, A decrease of this group of transitions was observed shortly after illumination and it was hardly detected in PLBs measured after the Chlide Shibata shift. Calorimetric results were supported by 77-K fluorescence emission spectra measured for continuously heated samples at different temperatures. We interpreted the DSC band observed between 20 and 45 degrees C as due to the disaggregation of Pchlide- (or Chlide-)-reductase-NADPH complexes, More detailed analysis using Gaussian deconvolution showed that this band was composed of three transitions at 32, 39 and 41 degrees C. The second group of transitions was detected in the 45-80 degrees C region, the same as for mature thylakoids. Its main component at 60 degrees C was not affected significantly by a short light pulse. By comparison of thermograms obtained for PLBs with those for mature thylakoid membranes, this transition was identified as the ATPase denaturation band. [less ▲]

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See detailEffects of isothiocyanates on the glutathione S-transferases activity from Adalia bipunctata L. (Coleoptera : Coccinellidae).
Francis, Frédéric ULg; Haubruge, Eric ULg; Gaspar, Charles

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (1999), 64(3a), 297-303

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See detailA sharp decrease of resistivity in La0.7Ca0.3Mn0.96Cu0.04O3: Evidence for Cu-assisted coherent tunneling of spin polarons
Sergeenkov, S. A.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in JETP Letters (1999), 69(11), 858-862

Nearly a 50% decrease of the resistivity rho(T,x) is observed upon just 4% Cu doping at the Mn site of La2/3Ca1/3Mn1-xCuxO3. When the observed phenomenon is attributed to a decrease of the spin-polaron ... [more ▼]

Nearly a 50% decrease of the resistivity rho(T,x) is observed upon just 4% Cu doping at the Mn site of La2/3Ca1/3Mn1-xCuxO3. When the observed phenomenon is attributed to a decrease of the spin-polaron energy E-sigma(x) below T-C(x), all of the data are found to be well fitted by the nonthermal coherent tunneling expression rho(T,x)=rho(0)e(-gamma M2(T,x)), assuming that the magnetization in the ferromagnetic state is given by the expression M(T,x)=M-R(x)+M-0(x)tanh{T-[root(C)(x)/T](2)-1}. The best fits through all the data points suggest M-0(x)similar or equal to root 1-xM(0)(0), M-R(x)similar or equal to x root M-0(0), and E-sigma(x)similar or equal to E-sigma(0)(1-x)(4) for the explicit x dependence of the Cu-induced modifications of the Mn-spin-dominated zero-temperature spontaneous magnetization, residual paramagnetic contribution, and spin-polaron tunneling energy, respectively, with E-sigma(0)=0.12 eV. (C) 1999 American Institute of Physics. [S0021-3640(99)00811-7]. [less ▲]

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See detailL'éclairage : une technique en évolution. Les méthodes de calcul et de simulation
Embrechts, Jean-Jacques ULg; Renglet, Michel; Eugène, Christian et al

in Revue E Tijdschrift (1999), 115è année, 3/4

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See detailBibliographie concernant la loi de protection des malades mentaux
Boxho, Philippe ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1999), 21

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See detailImpairment of neuromuscular transmission in a subgroup of migraine patients
Ambrosini, Anna; MAERTENS DE NOORDHOUT, Alain ULg; Alagona, Giovanna et al

in Neuroscience Letters (1999), 276(3), 201-3

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura ... [more ▼]

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholine release. Using single fiber EMG recordings we were able to demonstrate subclinical abnormalities of neuromuscular transmission in a subgroup of patients suffering from migraine with aura. This could be related to genetic abnormalities of P/Q Ca2+ channels in certain patients suffering from migraine with aura, which needs to be explored by proper genetic analyses. [less ▲]

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See detailA comparison of advanced thermal cycles suitable for upgrading existing power plant
Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Applied Thermal Engineering (1999), 19(3), 227-237

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants ... [more ▼]

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants using fossil fuels. Highly efficient cycles are available : gas turbines combined with waste heat boilers and steam cycles are able to achieve efficiencies above 50-55%. However building new plants requires a large amount of capital. Alternative proposals are based on upgrades of existing plants : capital savings are expected by reusing part of the facilities. In the present study, three parallel proposals are compared on the basis of exergy efficiency; cost of investment and flexibility of operation are also discussed. They are compared with classical Rankine cycle and state of the art combined cycles. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailCorticomotoneuronal synaptic connections in normal man. An electrophysiological study.
Maertens de Noordhout, Alain ULg

in Brain : A Journal of Neurology (1999), 122

In order to determine the mono- or oligosynaptic character of connections between pyramidal axons and individual spinal motor neurons, we constructed peri-stimulus time histograms (PSTHs) of the firing ... [more ▼]

In order to determine the mono- or oligosynaptic character of connections between pyramidal axons and individual spinal motor neurons, we constructed peri-stimulus time histograms (PSTHs) of the firing probability of voluntarily activated single motor units (SMUs) of various upper and lower limb muscles upon slightly suprathreshold transcranial anodal electrical stimulations of the motor cortex in normal subjects. Weak anodal cortical stimuli are known to activate preferentially fast-conducting pyramidal axons directly, bypassing cell bodies and cortical interneurons. A narrow bin width (0.1 ms) was chosen to measure precisely the duration of the PSTH excitatory peak, which corresponds to the rise time of the underlying compound excitatory post-synaptic potentials (EPSP). A short duration PSTH peak indicates sharp-rising EPSPs, most commonly encountered in the case of monosynaptic connections. In flexor carpi radialis and soleus SMUs, the PSTHs of built-in responses to anodal cortical stimuli were compared with those produced by 1A afferent stimulation able to elicit a Hoffmann reflex, which is known to be largely monosynaptic. In all upper and lower limb muscles, excitable SMUs responded to anodal cortical stimuli with a highly synchronized peak of increased firing probability. In flexor carpi radialis and soleus SMUs, the mean duration of this peak was significantly narrower than that evoked by 1A afferent stimulation, indicating that monosynaptic corticomotor neuronal transmission dominates low-threshold motor units, even in proximal arm and leg muscles. In the various muscles studied, and particularly in forearm SMUs, we did not observe broad PSTH peaks against the activation of non-monosynaptic corticomotor neuronal pathways, even with near-threshold stimuli. In some triceps and forearm flexor SMUs, subthreshold anodal pulses caused significant inhibition of their voluntary firing, with a latency consistent with activation of 1A inhibitory interneurons by the descending volleys. Measurements of the maximal number of counts in the excitatory PSTH peak upon anodal cortical stimuli provide comparisons of the strength of monosynaptic inputs to various muscles which seems to be maximal for hand and finger extensor muscles, and also for deltoid. [less ▲]

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See detailThree-dimensional Kinetic Energy Distributions of Ions using a Retarding Potential Analyser. Analysis of Discimination Effects by Ion Trajectory Simulations.
Hoxha, A.; Leyh, Bernard ULg; Locht, Robert ULg

in Rapid Communications in Mass Spectrometry : RCM (1999), 13

This paper presents a method of extracting three-dimensional kinetic energy distributions from retarding potential curves, suitable for analysing low kinetic energy releases. Trajectory calculations were ... [more ▼]

This paper presents a method of extracting three-dimensional kinetic energy distributions from retarding potential curves, suitable for analysing low kinetic energy releases. Trajectory calculations were performed which led to an analytical function correcting for the influence of discrimination against ions with velocity components perpendicular to the retarding field direction. The analysis of the thermal kinetic energy distribution of molecular vinyl bromide ions confirms the computed correcting factor. [less ▲]

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See detailEffects of Nimesulide and Sodium Diclofenac on Interleukin-6, Interleukin-8, Proteoglycans and Prostaglandin E2 Production by Human Articular Chondrocytes in Vitro
Henrotin, Yves ULg; Labasse, A. H.; Simonis, P. E. et al

in Clinical and Experimental Rheumatology (1999), 17(2), 151-60

OBJECTIVES: The aim of this study was to investigate the effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), nimesulide and sodium diclofenac, on the production of proteoglycans (PG ... [more ▼]

OBJECTIVES: The aim of this study was to investigate the effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), nimesulide and sodium diclofenac, on the production of proteoglycans (PG), prostaglandin E2 (PGE2) and cytokines (IL-6 and IL-8) by human articular chondrocytes in vitro. METHODS: Enzymatically isolated chondrocytes were cultured under constant agitation in a well defined culture medium. Specific radioimmunoassays were used to quantify PG and PGE2 production. Cytokine production (IL-6 and IL-8) was assayed by enzyme amplified sensitivity immunoassays (EASIAs). RESULTS: At a concentration of 3 micrograms/ml, nimesulide did not affect the PG production by chondrocytes. This concentration was superior to the highest level of nimesulide found in the synovial fluid of patients with rheumatoid arthritis 3 hours after the last oral administration of nimesulide (100 mg twice daily for 7 days). At 6 micrograms/ml a significant reduction in the PG content was obtained in the cellular phase in 5 out of the 8 cultures investigated. No similar effect was observed in the culture supernatants. Above this concentration nimesulide inhibited PG production in a dose-dependent manner. At concentrations ranging from 0.005 to 1 microgram/ml diclofenac did not significantly alter PG production. At therapeutic concentrations PGE2 production was totally inhibited by nimesulide, thus suggesting that PG inhibition is not linked to PGE2 production. Nimesulide inhibited PGE2 production by unstimulated (IC50 = 6 ng/ml) and IL-1 beta-stimulated (IC50 = 6.9 ng/ml) chondrocytes. At these concentrations, PGE2 production was fully inhibited by diclofenac. Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production. CONCLUSION: From the results of this study we conclude that nimesulide and diclofenac at therapeutic concentrations are potent inhibitors of PGE2 and IL-6 production while they do not modify proteoglycan or IL-8 production. [less ▲]

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See detailModelling the butterfat crystallisation process
Heyen, Georges ULg; Alleman, Xavier; Kalitventzeff, Boris ULg et al

in Computers & Chemical Engineering (1999), 23(Suppl. S), 819-822

Milk fat exhibits seasonal variations in composition and properties which are undesirable for many subsequent applications. Thus techniques are sought to process dairy products in order to achieve a ... [more ▼]

Milk fat exhibits seasonal variations in composition and properties which are undesirable for many subsequent applications. Thus techniques are sought to process dairy products in order to achieve a consistent quality. A brief introduction to milk fat presents its most important particularities, especially composition, seasonal variations, solid fat content, crystalisation and polymorphism. The differential scanning calorimetry (DSC) analysis allows to estimate the solid fat content. Different methods have been developed to estimate more and more precisely the solid fat content which is certainly an important parameter in the description of the textural properties of butterfat. The industrial crystallisation process is modelled on the basis of pilot plant data. That model allows to approach the particular temperature profile in the scraped surface heat exchangers and to give a first explanation of the involved phenomena. [less ▲]

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See detailOmtrek en oppervlakte van pixelfiguren
Bogaert, Jan ULg; Rousseau, R

in Wiskunde en Onderwijs (1999), 25

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See detailPharma-clinics le medicament du mois. Le naratriptan (naramig).
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(3), 189-91

Naratriptan, launched by Glaxo Wellcome under the trade name Naramig, is a potent and selective agonist of 5-HT1B and 5-HT1D vascular receptors. Available as tablets of 2.5 mg, it is indicated in the ... [more ▼]

Naratriptan, launched by Glaxo Wellcome under the trade name Naramig, is a potent and selective agonist of 5-HT1B and 5-HT1D vascular receptors. Available as tablets of 2.5 mg, it is indicated in the acute treatment of migraine, with or without aura. A single oral dose of 2.5 mg naratriptan is characterized by a satisfactory clinical efficacy (already significant after one hour, maximum after 4 hours and persisting during 24 hours), a reduction by half of the recurrence of the migraine crisis within the 24 hours and an excellent tolerance profile. [less ▲]

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See detailRole of the cholinergic pathway in mediating platelet-Activating factor-induced pulmonary dysfunctions in unsedated calves
Van de Weerdt, ML; Husson, Cécile; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1999), 46(2), 103-113

The purpose of this study was to investigate the possible role of the cholinergic pathway in mediating platelet-activating factor (PAF)-induced pulmonary dysfunctions in unsedated calves. In a placebo ... [more ▼]

The purpose of this study was to investigate the possible role of the cholinergic pathway in mediating platelet-activating factor (PAF)-induced pulmonary dysfunctions in unsedated calves. In a placebo group, PAF infusion challenge induced significant dysfunctions in the pattern of breathing [a significant increase in respiratory rate (RR) and a significant decrease in tidal volume (VT)], the mechanics of breathing [a significant increase in total lung resistance (RL) and a significant decrease in dynamic lung compliance (CLdyn)] and gas exchange, whereas in atropine pre-treated calves, PAF infusion challenge induced a significant increase in RR, VT and HR and a significant decrease in CLdyn. The RL increase was prevented by atropine pre-treatment. On the basis of our findings, we suggest that, in cattle, the PAF-induced pattern of breathing dysfunctions and the diffuse bronchoconstriction and microvascular leakage of small airways are not mediated through the cholinergic pathway. By contrast, our data suggest that PAF-induced bronchoconstriction of upper airways is at least partly mediated through muscarinic receptors. [less ▲]

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See detailComment on "physical reality of light-induced atomic states"
Schlagheck, Peter ULg; Hornberger, K.; Buchleitner, A.

in Physical Review Letters (1999), 82(3), 664-664

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See detailEffects of glucagon in the control of endogenous glucose production in man.
Surmely, J. F.; Schneiter, P.; Henry, S. et al

in Nutrition (1999), 15(4), 267-73

Endogenous glucose production has been shown to increase during administration of glucagon + fructose, but not during administration of fructose alone. To determine the mechanisms by which glucagon exerts ... [more ▼]

Endogenous glucose production has been shown to increase during administration of glucagon + fructose, but not during administration of fructose alone. To determine the mechanisms by which glucagon exerts this action, endogenous glucose production (EGP) and gluconeogenesis from fructose (GNF) were measured in eight healthy subjects infused 1) with graded doses of glucagon (2 and 4 ng.kg-1.min-1 for 3 h each) during constant infusion of 13C-fructose (3 mg.kg-1.min-1), and 2) with graded doses of 13C-fructose (3 and 6 mg.kg-1.min-1) during constant glucagon infusion (2 ng.kg-1.min-1). GNF was estimated from 13C-glucose synthesis. In both protocols, infusion of 3 mg.kg-1.min-1 fructose + 2 ng.kg-1.min-1 glucagon increased EGP by 5-8% (P < 0.05), while GNF represented 43-49% of EGP. Thereafter, increasing the glucagon infusion rate further increased EGP to 118 +/- 3% of basal values (P < 0.01) without altering the proportion due to GNF. In contrast, increasing the fructose infusion rate at constant glucagonemia increased EGP similarly (by 19 +/- 4%, P < 0.05) but enhanced the contribution of GNF to 76 +/- 2% (P < 0.001). Graded infusion of glucagon or fructose alone failed to stimulate EGP. The present findings indicate that hyperglucagonemia stimulates endogenous glucose production during fructose infusion. This effect is not secondary to a stimulation of gluconeogenesis, but to a channelling of glucose-6-phosphate towards systemic release. [less ▲]

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See detailEtude écosystémique d'une gravière de l'ancien lit majeur du Rhin (Krafft-Erstein, Bas-Rhin, France)
Klein, J. P.; Vanderpoorten, Alain ULg

in Martinia (1999), 15(1), 3-13

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See detailSyrie pré-hellénistique: Tell Beydar
Van der Stede, Véronique ULg; Talon, Philippe; van Berg, Paul-Louis

in Annales d'Histoire de l'Art et d'Archéologie (1999), XXI

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See detailSynthesis and pharmacological evaluation of KATP-channel openers related to cromakalim: introduction of arylsulphonylurea moieties
Khelili, S.; Nguyen, Q.-A.; Lebrun, P. et al

in Pharmacy and Pharmacology Communications (1999), 5

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See detailPubertal Growth as a Determinant of Adult Height in Boys with Constitutional Delay of Growth and Puberty
Rensonnet, Claudie ULg; Kanen, F.; Coremans, C. et al

in Hormone Research (1999), 51(5), 223-9

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult ... [more ▼]

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult height being above or below target height. In this retrospective study, adult height measured after 20 years in 39 patients was compared with target height and height data obtained at about 6 and 12 years of age and at diagnosis of delayed puberty (mean 14.6 years). Twenty-eight patients were untreated while 11 received testosterone enanthate (50 or 100 mg/month for 6 months). The growth data from both groups were pooled since they were not different. On average, the adult height standard deviation score (-0. 6 +/- 0.8, mean +/- SD) was similar to target height (-0.5 +/- 0.6). There were, however, marked individual differences since adult height varied between 1.7 SD (11 cm) below target height and 1.4 SD (9.5 cm) above target height. Multiple regression analysis showed that the most significant determinant of the difference between adult height and target height was height catch up during puberty (p < 0.002). We conclude that the magnitude of height catch up during puberty is a significant determinant of adult height in boys with constitutional delay of growth and puberty. Thus, optimizing pubertal growth may be a relevant therapeutic aim for adult height in boys with short stature and delayed puberty. Copyrightz1999S. KargerAG,Basel [less ▲]

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See detailLa loi du 10 juin 1998 relative à la prescription de l'action civile née d'une infraction
Jacobs, Ann ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detailRisedronate, a highly effective, short-term oral treatment for Paget’s disease: a dose-response study
Brown, JP; Hosking, DJ; Ste-Marie, LG et al

in Calcified Tissue International (1999), 64

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See detailTranscriptional Regulation Of The Mn/Ca 9 Gene Coding For The Tumor-Associated Carbonic Anhydrase Ix - Identification And Characterization Of A Proximal Silencer Element
Kaluz, S.; Kaluzova, M.; Opavsky, R. et al

in Journal of Biological Chemistry (1999), 274(46),

The MN/CA 9 (MN) gene encodes a tumor-associated isoenzyme of the carbonic anhydrase family. Functional characterization of the 3. 5-kilobase pair MN 5' upstream region by deletion analysis led to the ... [more ▼]

The MN/CA 9 (MN) gene encodes a tumor-associated isoenzyme of the carbonic anhydrase family. Functional characterization of the 3. 5-kilobase pair MN 5' upstream region by deletion analysis led to the identification of the -173 to +31 fragment as the MN promoter. In vitro DNase I footprinting revealed the presence of five protected regions (PRs) within the MN promoter. Detailed deletion analysis of the promoter identified PR1 and PR2 (numbered from the transcription start) as the most critical for transcriptional activity. PR4 negatively affected transcription, since its deletion led to increased promoter activity and was confirmed to function as a promoter-, position-, and orientation-independent silencer element. Mutational analysis indicated that the direct repeat AGGGCacAGGGC is required for efficient repressor binding. Two components of the repressor complex (35 and 42 kDa) were found to be in direct contact with PR4 by UV cross-linking. Increased cell density, known to induce MN expression, did not affect levels of PR4 binding in HeLa cells. Significantly reduced repressor level seems to be responsible for MN up-regulation in the case of tumorigenic CGL3 as compared with nontumorigenic CGL1 HeLa x normal fibroblast hybrid cells. [less ▲]

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See detailL'ostéoarthrose chez le chien - Pathophysiologie et diagnostic
Loneux, P.; Balligand, Marc ULg

in Annales de Médecine Vétérinaire (1999), (143), 153-160

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See detailLa pollution de la chaîne alimentaire par la dioxine
Maghuin-Rogister, Guy ULg; Delaunois, A.; De Pauwe, E. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailEffects of exercise on concentrations of immunoreactive endothelin in bronchoalveolar lavage fluid of normal horses and horses with chronic obstructive pulmonary disease
Benamou, A. E.; Art, Tatiana ULg; Marlin, David J et al

in Equine Veterinary Journal. Supplement (1999), 30

Chronic obstructive pulmonary disease (COPD) represents a major cause of loss of performance in the horse. The role of endothelin (ET), a potent bronchoconstrictive and vasoactive peptide, is currently ... [more ▼]

Chronic obstructive pulmonary disease (COPD) represents a major cause of loss of performance in the horse. The role of endothelin (ET), a potent bronchoconstrictive and vasoactive peptide, is currently being investigated in asthma and other obstructive respiratory diseases in man. We have previously found elevated systemic and pulmonary endothelin levels in horses during exacerbation of COPD. In the present study, our aim was to examine possible variations in ET concentrations occurring during exercise in COPD horses. We compared the effects of intense treadmill exercise on the recovery of endothelin (ET) in the bronchoalveolar lavage fluid (BALF) as well as in arterial and venous blood, in a group of 5 healthy horses and a group of 5 COPD horses studied alternately in remission and while symptomatic. We also investigated the possible correlations between ET levels and pulmonary function tests during the study. While exercise did not affect the ET levels recovered in BALF among controls, it caused a significant increase (P = 0.02) among symptomatic COPD horses. During remission, wide variations of ET levels among horses, at rest and during exercise, made any significant interpretation difficult. No correlation could be found between exercise-induced changes in ET concentrations and pulmonary function tests or changes in arterial oxygen tension with exercise. We conclude that exercise appears to affect the release of ET by the airways in COPD horses, in contrast to healthy horses. It is still unclear, however, whether these differences relate to adjustments of lung function during exercise. [less ▲]

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See detailValidation of an automated method for the liquid chromatographic determination of atenolol in plasma: application of a new validation protocol
Chiap, Patrice ULg; Hubert, Philippe ULg; Boulanger, Bruno ULg et al

in Analytica Chimica Acta (1999), 391(2), 227-238

In order to test the applicability of a new strategy by a Commission of the Societe Francaise des Sciences et Techniques Pharmaceutiques (SFSTP) for the validation of bioanalytical methods, an automated ... [more ▼]

In order to test the applicability of a new strategy by a Commission of the Societe Francaise des Sciences et Techniques Pharmaceutiques (SFSTP) for the validation of bioanalytical methods, an automated method was developed for the determination of atenolol in human plasma. This method was based on the use of dialysis as sample purification step, followed by enrichment of the dialysate on a precolumn and liquid chromatographic analysis. All sample handling operations were carried out automatically by means of an ASTED system. Atenolol and its internal standard (sotalol) were separated on a C-8 column with a mixture of pH 7.0 phosphate buffer containing 1-octanesulphonate and methanol (81/19; v:v) as mobile phase and monitored photometrically at 225 nm. The validation strategy comprises two steps. The experiments performed during the first step, the so called pre-validation step, have permitted the selection of the most appropriate model for the calibration curve by means of a decision tree, i.e. a least squares regression model obtained after transformation of data (square root in this case), the estimation of the limit of quantitation at 25 ng/ml by means of an accuracy profile, the determination of the calibration range (from 25 to 1000 ng/ml), the estimation of the limit of detection at 9 ng/ml and the calculation of the mean extraction efficiency (about 65%). The second step is the validation itself, comprising the evaluation of method selectivity towards endogenous components, the confirmation of the limit of quantitation, the verification of linearity and the assessment of method precision (repeatability and intermediate precision) as well as accuracy using quality control samples at different concentration levels over the range investigated. The relative standard deviation values for repeatability and intermediate precision were between 2.7% and 9.0%. Moreover, the method was found to be accurate. Indeed, the 95% one-sided confidence limits of the mean recovery did not exceed the acceptance limits of 80% and 120%. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailCrystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis.
Bompard-Gilles, C; Villeret, V; Fanuel, L et al

in Acta Crystallographica Section D-Biological Crystallography (1999), 55(Pt 3), 699-701

Ochrobactrum anthropi possesses an L-aminopeptidase (DmpA) also able to act as a D-amidase/D-esterase. DmpA (40 kDa) is activated by auto-catalyzed protein splicing liberating an alpha-amino group ... [more ▼]

Ochrobactrum anthropi possesses an L-aminopeptidase (DmpA) also able to act as a D-amidase/D-esterase. DmpA (40 kDa) is activated by auto-catalyzed protein splicing liberating an alpha-amino group presumably used as a general base in the catalytic mechanism. Two crystal forms were obtained at 294 K in 13-16% PEG 2000 mono-methylether at pH 9.0, adding either 0.2 M magnesium chloride or 1 M lithium chloride. Crystals of the first form belong to the space group C2221 and diffract to 3.0 A resolution, whereas crystals of the second form belong to the space group P21212 and diffract to 2.3 A resolution. Initial screening for heavy-atom derivatives on form II crystals, has led to a well substituted Hg derivative. [less ▲]

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See detailKarst dans les micaschistes d'Akok Bekoé - Sud Cameroun
Willems, Luc ULg; Vicat, Jean-Paul; Pouclet, André

in Bulletin de la Société Géographique de Liège (1999), 37(2), 5-18

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those ... [more ▼]

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those found in the karst limestones. The presence of a spring and the proximity of the Nyong river suggest that a chemical erosion within an aquifer is at the origin of most of forms. The position of certain conduits and tafonis dismisses the assumption of a genesis within a weathering mantle. [less ▲]

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See detailAnalyse préliminaire de la situation et des perspectives de la culture du haricot de Lima (Phaseolus lunatus L.) sur la Côte péruvienne (Vallées d'Ica, Pisco et Casma).
Rouschop, P.; Baudoin, Jean-Pierre ULg; Mayta, F. C. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(2), 115-126

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See detailLa maîtrise de son corps par la personne
Genicot, Gilles ULg; Leleu, Yves-Henri ULg

in Journal des Tribunaux (1999)

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See detailComparing global models of terrestrial net primary productivity (NPP): analysis of the seasonal atmospheric CO2 signal
Nemry, B.; François, Louis ULg; Gérard, Jean-Claude ULg et al

in Global Change Biology (1999), 5(Suppl. 1), 65-76

Eight terrestrial biospheric models (TBMs) calculating the monthly distributions of both net primary productivity (NPP) and soil heterotrophic respiration (R-H) in the Potsdam NPP Model Intercomparison ... [more ▼]

Eight terrestrial biospheric models (TBMs) calculating the monthly distributions of both net primary productivity (NPP) and soil heterotrophic respiration (R-H) in the Potsdam NPP Model Intercomparison workshop are used to simulate seasonal patterns of atmospheric CO2 concentration. For each model, we used net ecosystem productivity (NEP=NPP-R-H) as the source function in the TM2 atmospheric transport model from the Max-Planck Institute for Meteorology. Comparing the simulated concentration fields with detrended measurements from 25 monitoring stations spread over the world, we found that the decreasing seasonal amplitude from north to south is rather well reproduced by all the models, though the amplitudes are slightly too low in the north. The agreement between the simulated and observed seasonality is good in the northern hemisphere, but poor in the southern hemisphere, even when the ocean is accounted for. Based on a Fourier analysis of the calculated zonal atmospheric signals, tropical NEP plays a key role in the seasonal cycle of the atmospheric CO2 in the whole southern hemisphere. The relatively poor match between measured and predicted atmospheric CO2 in this hemisphere suggests problems with all the models. The simulation of water relations, a dominant regulator of NEP in the tropics, is a leading candidate for the source of these problems. [less ▲]

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See detailDirect costs of hip fractures in patients over 60 years of age in Belgium.
Reginster, Jean-Yves ULg; Gillet, Philippe ULg; Ben Sedrine, Wafa ULg et al

in PharmacoEconomics (1999), 15(5), 507-514

OBJECTIVE: Osteoporosis-related costs are now considered a major burden for health authorities in most developed countries. An accurate and exhaustive evaluation of these costs would be a major ... [more ▼]

OBJECTIVE: Osteoporosis-related costs are now considered a major burden for health authorities in most developed countries. An accurate and exhaustive evaluation of these costs would be a major contribution to health economic studies evaluating the efficiency of screening and prevention strategies. Osteoporosis is the most frequent underlying cause of femoral neck fractures in the elderly; these fractures weigh heavily on healthcare budgets. However, in Belgium, very few data on the financial burden of hip fractures are available and no updated estimates have been made. The goal of this paper is to estimate the direct medical expenditures associated with hip fractures in Belgium in 1996. DESIGN AND SETTING: This 1-year population-based cross-sectional study is conducted from the social security perspective. The target population in this study are men and women aged 60 years and over. PATIENTS AND PARTICIPANTS: We selected patients who had been hospitalised for a hip fracture during the year 1996 who were also affiliated with a registered social security organisation (covering 25% of the Belgian population). The sample constituted 2374 patients. INTERVENTIONS: For each of these patients, we collected an exhaustive and detailed list of healthcare resource use as well as nursing home admissions following the hip fracture event. Cost items investigated in the analysis were inpatient hospital costs and outpatient costs. Mean annual costs per case recorded in the sample were then extrapolated to the whole country on the basis of an exhaustive list of diagnoses having lead to all countrywide hospitalisations (1,700,000 hospital stays/year). MAIN OUTCOME MEASURES AND RESULTS: The mean hospital inpatient costs for hip fracture were evaluated at 332,148 Belgian francs (BeF) [$US8977] per case and BeF4,367,746,200 ($US118,047,194) for the whole country (10 million inhabitants). Patients with a hip fracture experienced an annual BeF27,825 ($US752) extra outpatient cost during the year following this fracture event, after correcting for costs related to additional comorbidity already present before the hip fracture. Finally, after a proximal femoral neck fracture, the rate of nursing home admission was higher, both for men and women at any age compared with age- and gender-matched population. CONCLUSIONS: With a total cost (acute hospital and outpatient costs) of BeF4,667,894,950 ($US126,159,323) per year in Belgium, proximal femoral neck fracture should be considered a major health economic problem and appropriate measures to prevent this disease should be rapidly undertaken. [less ▲]

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See detailMachiavellian Rethoric. From the Counter-Reformation to Milton, Princeton.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1999)

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See detailThe effects of training on ventilation and blood gases in exercising Thoroughbreds
Roberts, C. A.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1999), 30

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the ... [more ▼]

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the type frequently used for Thoroughbred racehorses in Great Britain. Standardized treadmill exercise tests (2 min canter at 8 and 10 m/s C8 and C10[ and 2 min gallop at 12 m/s [G12], on a level surface) were performed prior to and after 16 weeks of training. Respiratory flow rates were measured using ultrasound flow transducers. Blood samples were drawn from a transverse facial artery and the right atrium. Minute ventilation, respiratory frequency and tidal volume were not significantly altered by training. Peak inspiratory flow rate was lower following training at 8 and 10 m/s, but not at 12 m/s. Arterial oxygen tension was decreased during trot and canter following training. Blood lactate concentration post G12 decreased following training (10.5 +/- 2.2 mmol/l vs. 7.7 +/- 2.2 mmol/l; P < 0.05). The increase in the degree of exercise-induced arterial hypoxaemia following training may reflect a lack of pulmonary adaptation to training in the face of improved cardiovascular and muscular function. [less ▲]

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See detailApplication and performances of graphitic chromium cast iron rolls
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Breyer, J. P. et al

in Revue de Métallurgie [=Revue de Métallurgie. Cahiers d'Informations Techniques] (1999), 96(11), 1401-1411

The main requirements for the development of a new grade for the later finishing section of the mill are : good oxidation and thermal behaviour, high wear resistance, good resistance to rolling incidents ... [more ▼]

The main requirements for the development of a new grade for the later finishing section of the mill are : good oxidation and thermal behaviour, high wear resistance, good resistance to rolling incidents. The approach of Marichal Ketin to improve the rolling performances in the last finishing stands is presented. The Hi-Cr cast iron possesses excellent wear resistance due to the presence of hard chromium carbides, but its thermal conductivity and sticking properties are fairly low. A graphite precipitation could contribute to an improvement in thermal conductivity and serve as lubricant preventing sticking. The new material, called graphitic chromium iron, shows good oxidation, wear and thermal behaviour allowing its use as work roll in the last stands of the finishing section of a HSM. In the as-cast condition, graphite precipitation in high Ni and Si chromium cast iron occurs at a temperature of 950 degrees C. Moreover, the amount and volume of free graphite may be increased by secondary graphite precipitation during suitable heat treatment. [less ▲]

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See detailThe value of pretreatment cell kinetic parameters as predictors for radiotherapy outcome in head and neck cancer : a multicenter analysis.
Begg, A-C; Hart, AAM; Dische, S et al

in Radiotherapy & Oncology (1999), 50

Purpose: The aim of this study was to assess the potential of pre-treatment cell kinetic parameters to predict outcome in head and neck cancer patients treated by conventional radiotherapy. Materials and ... [more ▼]

Purpose: The aim of this study was to assess the potential of pre-treatment cell kinetic parameters to predict outcome in head and neck cancer patients treated by conventional radiotherapy. Materials and methods: Data from 11 different centers were pooled. Inclusion criteria were such that the patients received radiotherapy alone, and that the radiotherapy was given in an overall time of at least 6 weeks with a dose of at least 60 Gy. All patients received a tracer dose of either iododeoxyuridine (IdUrd) or bromodeoxyuridine (BrdUrd) intravenously prior to treatment and a tumor biopsy was taken several hours later. The cell kinetic parameters labeling index (LI), DNA synthesis time (Ts) and potential doubling time (Tpot) were subsequently calculated from flow cytometry data, obtained on the biopsies using antibodies against I/BrdUrd incorporated into DNA. Each center carried out their own flow cytometry analysis. Results: From the 11 centers, a total of 476 patients conforming to the inclusion criteria were analyzed. Median values for overall time and total dose were 49 days and 69 Gy, respectively. Fifty one percent of patients had local recurrences and 53% patients had died, the majority from their disease. Median follow-up was 20 months; being 30 months for surviving patients. Multivariate analysis revealed that T-stage, maximum tumor diameter, differentiation grade, N-stage, tumor localization and overall time correlated with locoregional control, in decreasing order of significance. For the cell kinetic parameters, univariate analysis showed that only LI was significantly associated with local control (P=0.02), with higher values correlating with a worse outcome. Ts showed some evidence that patients with longer values did worse, but this was not significant (P=0.06). Tpot showed no trend (P=0.8). When assessing survival in a univariate analysis, neither LI nor Tpot associated with outcome (P=0.4, 0.4, respectively). Surprisingly, Ts did correlate with survival, with longer values being worse (P=0.02). In the multivariate analysis of local control, LI lost its significance (P=0.16). Conclusions: The only pretreatment kinetic parameter for which some evidence was found for an association with local control (the best end-point for testing the present hypothesis) was LI, not Tpot, and this evidence disappeared in a multivariate analysis. It therefore appears that pretreatment cell kinetic measurements carried out using flow cytometry, only provide a relatively weak predictor of outcome after radiotherapy in head and neck cancer. [less ▲]

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See detailOn the use of the Cowan's code for atomic structure calculations in singly ionized lanthanides
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg

in Journal of Quantitative Spectroscopy & Radiative Transfer (1999), 62

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See detailLa greffe de cellules souches hematopoietiques dans la drepanocytose.
Cornu, G.; Vermylen, C.; Ferster, Aline et al

in Archives de Pédiatrie (1999), 6 Suppl 2

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See detailFauna vs flora contribution to the leaf epiphytes biomass in a Posidonia oceanica seagrass bed (Revellata Bay, Corsica).
Lepoint, Gilles ULg; Havelange, Stéphane; Gobert, Sylvie ULg et al

in Hydrobiologia (1999), 394

The epiphyte biomass of Posidonia oceanica (L.) Delile leaves is mainly related to the substrate leaf availability. It decreases with increasing depth and increases from winter to summer, following the ... [more ▼]

The epiphyte biomass of Posidonia oceanica (L.) Delile leaves is mainly related to the substrate leaf availability. It decreases with increasing depth and increases from winter to summer, following the leaf biomass changes. In Revellata Bay (Gulf of Calvi, Corsica), at shallow depth (10m in this study) where photophilous algae grow, the fixed epifauna biomass accounts for about one third of leaf epiphytes biomass. At deeper depths in the Revellata Bay (20 and 30m), where shade-tolerant algae are dominant among epiflora, epifauna may account for more than half the leaf epiphytes biomass. [less ▲]

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See detailMadangolide and Laingolide A, Two Novel Macrolides from Lyngbya bouillonii (Cyanobacteria)
Klein, D.; Daloze, D.; Hoffmann, L. et al

in Journal of Natural Products (1999)

Two new macrolide derivatives, madangolide (2) and laingolide A (3), have been isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Their structures (without stereochemistry ... [more ▼]

Two new macrolide derivatives, madangolide (2) and laingolide A (3), have been isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Their structures (without stereochemistry) have been established by detailed high-field 1D and 2D NMR studies and, in the case of 3, by comparison with the spectroscopic data of laingolide (1), previously isolated from the same organism. [less ▲]

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See detailLes adénovirus recombinants comme vecteurs vaccinaux
Gogev, S.; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (1999), 143

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See detailQuantitative determination of haptoglobin (HAP) in human and bovine sera by capillary zone electrophoresis (CZE).
Pirlot, Alain ULg; Janssens, J.; Skinner, G. et al

in Veterinary research (1999), 30(5), 483-93

This study describes an original assay for serum haptoglobin determination by measuring the capacity of human haptoglobin (hHAP) and bovine haptoglobin (bHAP) to bind haemoglobin (Hb) as established by ... [more ▼]

This study describes an original assay for serum haptoglobin determination by measuring the capacity of human haptoglobin (hHAP) and bovine haptoglobin (bHAP) to bind haemoglobin (Hb) as established by capillary zone electrophoresis (CZE). This method involves the addition of Hb in excess to the serum and the separation of the HAP-Hb complexes from free haemoglobin by CZE. Protein migration was recorded at a wavelength of 415 nm which reveals Hb alone (free or bound), and the concentration of HAP was indirectly estimated by measuring bound Hb. Different CZE conditions and the peak migration time of Hb from various species (human, equine, bovine, canine) were investigated. The electrophoretic separation of free human Hb (hHb) in excess and the hHAP-hHb complex was fully achieved by CZE, allowing a quantitative determination of hHAP. However, bovine haemoglobin (bHb) bound to bHAP and free bHb were poorly separated under the same conditions. The best detachment between bHAP-Hb complexes and free Hb was only attained in the bovine sample by use of canine haemoglobin (cHb). CZE assays performed with cHb gave very close values to those of a classic photometric method which measured the peroxidase activity of the haptoglobin-cyanmethaemoglobin complexes (y = 1.0168x - 0.072; r2 = 0.97). CZE assay was fast (< 10 min), inexpensive, did not require the use of a specific antibody and was reproducible (coefficient of variation, CV 3.6%). [less ▲]

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See detailThe neural correlates of updating information in verbal working memory
Van der Linden, Martial ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Memory (1999), 7(5-6), 549-560

The aim of the present study was to re-examine cerebral areas subserving the updating function of the central executive with a running span task requiring subjects to watch strings of consonants of ... [more ▼]

The aim of the present study was to re-examine cerebral areas subserving the updating function of the central executive with a running span task requiring subjects to watch strings of consonants of unknown length and then to recall serially a specific number of recent items. In order to dissociate more precisely the updating process from the storage function, a four-item instead of a six-item memory load was used, contrary to our previous study (Salmon et al., 1996). In addition, a serial recall procedure was preferred to a recognition procedure in order to suppress the use of visuospatial strategies. The most significant increase of rCBF occurred in the left frontopolar cortex (Brodmann's area 10), spreading to the left middle frontal (Brodmann's area 46). Results suggest that frontopolar activation underlies an updating process in working memory. [less ▲]

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See detailThe ribonucleoside diphosphate reductase inhibitor (E)-2'-Deoxy-(fluoromethylene) cytidine, acts as a cytotoxic radiosensitizer on human cancer cell lines in vitro.
Coucke, Philippe ULg; Decosterd, L-A; Li, Y-X et al

in Cancer Research (1999), 59

ABSTRACT (E)-2*-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier ... [more ▼]

ABSTRACT (E)-2*-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier of radiation response in vitro on a human colon carcinoma cell line (WiDr), and the observed radiosensitization was confirmed on two human cervix cancer cell lines (C33-A and SiHa). Using the clonogenic assay, the effect ratio (ER) at a clinically relevant dose level of 2 Gy was 2.10 (50 nM FMdC), 1.70 (30 nM FMdC), and 1.71 (40 nM FMdC) for the three cell lines WiDr, C33-A, and SiHa, respectively. A more detailed analysis of the importance of timing and concentration of FMdC was done on the WiDr cell line alone, yielding an increased ER(2Gy) with increasing concentration and duration of exposure to the drug, ranging from 1.0 (6 h) to 1.8 (72 h) at 30 nM FMdC and from 1.2 (6 h) to 3.5 (24 h) at 300 nM. We investigated the effect of FMdC on the cellular deoxynucleotide triphosphate pool in WiDr cells and demonstrated a marked depletion of dATP and a significant rise of TTP levels. Cell cycle analysis showed early S-phase accumulation induced by FMdC alone, G2-M block induced by irradiation alone, and an increased accumulation of cells in G2-M if both modalities are used. Our data suggest that FMdC is a radiation response modifier in vitro on different cancer cell lines. The observed radiosensitization may in part be explained by alteration of the deoxynucleotide triphosphate pool, which is consistent with the effect of FMdC on ribonucleoside diphosphate reductase. [less ▲]

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See detailMigrants and Ethnic Minorities in Europe: Scapegoats or social Actors ? - D. Joly
Martiniello, Marco ULg

in Ethnic and Racial Studies (1999), 22(5), 909-910

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See detailGenes for rare idiopathic generalized epilepsies: BFNC.
Singh, N.; Charlier, Carole ULg; Peiffer, A. et al

in Advances in neurology (1999), 79

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See detailLe point de vue de l'économiste
Jurion, Bernard ULg

in La nouvelle procédure fiscale, Commision Université-Palais (1999), XXX(II), 99-108

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See detailL'incontinence urinaire chez la femme agee.
Fillet, Marc ULg; Bonnet, Pierre ULg; de Leval, Jean ULg

in Revue Médicale de Liège (1999), 54(4), 341-8

Physical, psychological and economical consequences of urinary incontinence of the elderly woman are underestimated. It often results in depression, social isolation and early institutionalisation. It is ... [more ▼]

Physical, psychological and economical consequences of urinary incontinence of the elderly woman are underestimated. It often results in depression, social isolation and early institutionalisation. It is often the key factor that determines the decision of institutionalisation, which represent the most important part of the total cost of urinary incontinence. This problem is too often neglected and deserves considerable attention. [less ▲]

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See detailLes convergences culturelles dans les sociétés pluriethniques de K. Fall et al.
Martiniello, Marco ULg

in Recherches Sociologiques (1999), 2

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See detailLes adolescents qui abusent sexuellement des enfants
Malchair, Alain ULg

in Revue Médicale de Liège (1999), 54(6), 527-534

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See detailRegulation of cancer invasion and vascularization by plasminogen activator inhibitor-1
Noël, Agnès ULg; Bajou, Khalid ULg; Masson, Véronique ULg et al

in Fibrinolysis and Proteolysis (1999), 13(6), 220-225

Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of ... [more ▼]

Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of urokinase-type plasminogen activator (urokinase, uPA) or tissue-type plasminogen activator (tPA). Plasminogen activator inhibitor-1 or PAI-1 is the main inhibitor of uPA and tPA. High levels of components of this proteolytic system, including uPA and its cell surface receptor (uPAR), have been correlated with a poor prognosis for different cancers. It was therefore anticipated that PAI-1 expression would be associated with favorable outcome. Paradoxically, high rather than low PAI-1 levels predict poor survival of patients suffering from a variety of cancers. Recent observations indicate a much more complex role of PAI-1 in tumor progression and angiogenesis than initially expected. The exact mechanisms of this multifunctional molecule remain puzzling. [less ▲]

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See detailLa démocratie et le lieu vide du pouvoir
Delruelle, Edouard ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1999), 85-87

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See detailFrom Neural Stem Cells to Myelinating Oligodendrocytes
Rogister, Bernard ULg; Ben Hur, Tamir; Dubois-Dalcq, Monique

in Molecular & Cellular Neuroscience [=MCN] (1999), 14

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See detailL'analyse discriminante décisionnelle : principes et application
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1999), (4), 41

The principles of discriminant analysis are described and illustrated by the iris data set published by Fisher [1936].

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See detailActualites therapeutiques 1999.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(9), 725-34

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be stressed. [less ▲]

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See detailParticularités de la contraction électro-induite : implications rééducatives
Vanderthommen, Marc ULg; Zahlan, O.; BAUVIR, Philippe ULg et al

in Kine 2000 (1999), 10

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See detailThe Farrakhan Phenomenon - R. Singh
Martiniello, Marco ULg

in Nationalism & Ethnic Politics (1999), 5(3-4), 282-283

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See detailQuête de reliques en Sardaigne pour le prieuré Saint-Léonard de Liège (1642-1650)
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (1999)

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See detailThe great-grand-daughter design: a simple strategy to increase the power of a grand-daughter design for QTL mapping
Coppieters, Wouter ULg; Kvasz, A.; Arranz, J. J. et al

in Genetical Research (1999), 74

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See detailThe Development of a methodology to measure fearfullness in horses. Waltham Symposium "The role of the horse in Europe"
Vierin, M.; Vandenheede, Marc ULg; Bouissou, Marie-France et al

in Equine Veterinary Journal. Supplement (1999), 28

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See detailIntroduction
Martiniello, Marco ULg; Statham, Paul

in Journal of Ethnic & Migration Studies (1999), 25(4), 565-573

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See detailGezelle, mens en onmens
Spinoy, Erik ULg

in Gezelliana. Kroniek van de Gezellestudie (1999)

This article reflects on how the work of the reactionary 19th-century Flemish poet Guido Gezelle can be 'saved' through innovative rereadings.

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See detailThe mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse
Schurmans, Stéphane ULg; Carrio, R.; Behrens, J. et al

in Genomics (1999), 62

SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic ... [more ▼]

SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic domain, and a 3' proline-rich region. Recent results suggest that SHIP2 and SHIP1 act downstream of various receptors by removing a phosphate from the 5' position of the phosphatidylinositol 3'-kinase phosphatidylinositol 3,4, 5-triphosphate product and of inositol 1,3,4,5-tetrakisphosphate. Human SHIP2 is highly expressed in adult heart, skeletal muscle, and placenta, whereas SHIP1 expression is limited to the hematopoietic system. We report here the molecular analysis of the mouse SHIP2 cDNA and the corresponding protein, the structure of the gene, and the identification of its promoter. SHIP2 mRNA expression was analyzed in embryonic and adult mouse tissues by reverse transcription-polymerase chain reaction and in situ hybridization. In embryonic day 15.5 mice, SHIP2 was strongly expressed in the liver, specific regions of the central nervous system, the thymus, the lung, and the cartilage perichondrium. In adult mice, SHIP2 mRNA was markedly present in the brain and the thymus and at different stages of spermatozoa maturation in the seminiferous tubules. The subtle differences in the protein structure of SHIP2 and SHIP1 as well as their different patterns of expression are discussed [less ▲]

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See detailDe nouveaux acteurs dans la physiopathologie du metabolisme de l'eau: les aquaporines
Pequeux, Christel ULg; Brilot, Fabienne; Martens, Henri ULg et al

in Revue Médicale de Liège (1999), 54(11), 867-74

Aquaporins are transmembrane proteins mediating water transport across plasma membrane of animal, vegetal or bacterial cells. Among the ten aquaporins known in mammals, six are located in kidney and take ... [more ▼]

Aquaporins are transmembrane proteins mediating water transport across plasma membrane of animal, vegetal or bacterial cells. Among the ten aquaporins known in mammals, six are located in kidney and take part in urine concentration. AQP2 is vasopressin regulated, it is the only family member to be implicated in human pathology, such as nephrogenic diabetes insipidus, congestive heart failure, hepatic cirrhosis, nephrotic syndrome or SIADH. Aquaporins are expressed in a wide variety of tissues, such as brain or gastrointestinal tractus, and suggest a role in water tissue exchange, but their real function is still not define. To know the physiological impact of aquaporins, AQP1, AQP3, AQP4 and AQP5 knockout mice have been created and their phenotype analysed. [less ▲]

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See detailUn site internet dédié à la réactivation des bases de chimie à l'entrée à l'Université
Müller, Robert; Cornélis, André; Cahay, René et al

in Chimie Nouvelle (1999), 17

http:/ /www.ulg.ac.be/grptrans/ : sur ce site, nous mettons à Ia disposition de Ia communauté éducative (étudiants et enseignants) un outil intégré d'évaluation interactive et de réactivation des notions ... [more ▼]

http:/ /www.ulg.ac.be/grptrans/ : sur ce site, nous mettons à Ia disposition de Ia communauté éducative (étudiants et enseignants) un outil intégré d'évaluation interactive et de réactivation des notions fondamentales de chimie à la charnière entre I'Enseignement Secondaire et I'Université. [less ▲]

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See detailKinetic Energy Release Distributions in the Dissociation of Energy-Selected Fluoroethene and 1,1-Difluoroethene Ions.
Güthe, F.; Locht, Robert ULg; Leyh, Bernard ULg et al

in Journal of Physical Chemistry A (1999), 103

The unimolecular dissociation of energy-selected fluoroethene and 1,1-difluoroethene ions has been investigated by threshold photoelectron photoion coincidence TPEPICO) technique. The breakdown diagrams ... [more ▼]

The unimolecular dissociation of energy-selected fluoroethene and 1,1-difluoroethene ions has been investigated by threshold photoelectron photoion coincidence TPEPICO) technique. The breakdown diagrams of the 1,1-difluorethene and fluoroethene have been recorded between 13-22 eV. From time-of-flight (TOF) spectra, complete distributions of the kinetic energy released (KERD) in the dissociation of these energy-selected ions have been derived. For the HF-loss reaction channel, the KERD peaks at about 200 meV for low excitation energies but becomes thermal at higher excitation energies. For the F-loss channel, the KERD peaks at zero kinetic energy for low excitation energies but at about 200 meV for high excitation energy. The analysis of the KERD provides evidence that consecutive fragmentation takes place for the 1,1-difluoroethene at energies above 19 eV. [less ▲]

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See detailOral status and nutrition in the institutionalized elderly.
Lamy, Marc ULg; Mojon, P.; Kalykakis, G. et al

in Journal of Dentistry (1999), 27(6), 443-8

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more ... [more ▼]

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more subjective eating difficulty and increased mashed food consumption. METHODS: An oral examination and an evaluation of masticatory capacity were performed on 120 institutionalized elderly subjects. The nutritional assessment included serum albumin concentration, the Mini Nutritional Assessment and a questionnaire on eating habits. RESULTS: Edentulous subjects without dentures or with only one complete denture had significantly lower MNA scores than edentulous subjects with two complete dentures (p < 0.05). Edentulous subjects with two complete dentures more frequently reported taking pleasure from eating (p = 0.05), and had less frequent difficulties with hard foods (p = 0.01) than edentulous subjects without dentures or with only one complete denture. Mashed food consumption (p < 0.01) was also reported more frequently in edentulous subjects without dentures or with only one complete denture. Subjects with two complete dentures had similar or better MNA scores as dentate subjects with relatively few remaining teeth (10.4 +/- 7.8 teeth). About half of the subjects (53%) could not perform the masticatory test. These subjects had lower MNA scores (p = 0.001) and a larger proportion ate mashed food (p < 0.001) compared to those who were able to perform the test. CONCLUSIONS: Poor oral status (edentulous without dentures or with only one complete denture) increased difficulty in eating hard foods, increased mashed food consumption and decreased eating pleasure. It seemed also to put institutionalized subjects at higher risk of undernutrition. [less ▲]

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See detailCharacterization of YKL165c a new essential gene of the yeast Saccharomyces cerevisiae.
Delbecq, X.; Godrie, Thérèse ULg; Portetelle, Daniel ULg et al

in Current Genetics (1999), 35

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See detailTreatment of Inflammatory Bowel Disease with Azathioprine: How to Use It in 1999
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1999), 62(4, Oct-Dec), 437-9

Azathioprine and 6-mercaptopurine are effective drugs in the management of steroid dependent and chronic active inflammatory bowel diseases. They are also well tolerated on the long term. However, their ... [more ▼]

Azathioprine and 6-mercaptopurine are effective drugs in the management of steroid dependent and chronic active inflammatory bowel diseases. They are also well tolerated on the long term. However, their use is still hampered by some drawbacks including delay before efficacy, 20-35% of non responders, relapse at withdrawal of the drugs, possible bone marrow toxicity and other side effects. During the last few years, these drawbacks have been challenged by important studies showing that a better knowledge of the metabolism of these drugs may help to improve their use. [less ▲]

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See detailCompte-rendu de Jocelyn Benoist, L'a priori conceptuel. Bolzano, Husserl, Schlick
Leclercq, Bruno ULg

in Recherches Husserliennes (1999), 12

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See detailLe trésor des reliques de l'abbaye Saint-Hubert en Ardenne
George, Philippe ULg

in Études & Documents de la Région Wallonne. Monuments & Sites (1999)

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