References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailPolymerization-filled composites prepared with highly active filler-supported Al/Ti/Mg catalysts. II. Properties of homogeneous polyethylene-based
Hindryckx, François; Dubois, Philippe; Jérôme, Robert ULg et al

in Journal of Applied Polymer Science (1997), 64(3), 439-454

Polyethylene-based composites have been prepared by ethylene polymerization with a Al/Ti/Mg catalyst previously deposited on the surface of kaolin (Satintone W/W and Satintone 5) or barite.(1) Molecular ... [more ▼]

Polyethylene-based composites have been prepared by ethylene polymerization with a Al/Ti/Mg catalyst previously deposited on the surface of kaolin (Satintone W/W and Satintone 5) or barite.(1) Molecular weight (M(w)) of the polyethylene matrix has been estimated from melt viscosity under steady shear flow and compared to the value measured by size exclusion chromatography. Tensile stress and strain, Young modulus, and impact energy have been measured in relation to the matrix molecular weight and the filler content. The effect of the main polymerization parameters, such as the Al/Ti/Mg composition, the addition of a transfer agent, e.g., an alpha-olefin or hydrogen, have also been investigated. These tensile and impact properties have been compared to composites of the same composition but prepared by melt blending of the filler and the preformed polyolefin. As a rule, the polymerization-filled composites have an improved mechanical strength compared to the analogues prepared by melt blending. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Peer Reviewed
See detailUse of an Automatic DNA Sequencer for S1 Mapping: Transcriptional Analysis of the Streptomyces Coelicolor A3(2) Dnak Operon
Brans, Alain ULg; Loriaux, Axelle; Thamm, Iris ULg et al

in FEMS Microbiology Letters (1997), 149(2), 189-94

The transcription start point of the dnaK operon of Streptomyces coelicolor A3(2) has been determined by S1 mapping, using the EMBL automated fluorescent DNA sequencer. The -35 and -10 hexamers correspond ... [more ▼]

The transcription start point of the dnaK operon of Streptomyces coelicolor A3(2) has been determined by S1 mapping, using the EMBL automated fluorescent DNA sequencer. The -35 and -10 hexamers correspond to a sigma 70-type promoter. This promoter responds to heat shock and involves an inverted repeat different from the CIRCE sequence characteristic of the Gram-positive heat-shock promoters. [less ▲]

Detailed reference viewed: 45 (8 ULg)
Full Text
Peer Reviewed
See detailMacromolecular engineering of polylactones and polylactides. 23. Synthesis and characterization of biodegradable and biocompatible homopolymers and block copolymers based on 1,4,8-trioxal [4.6] spiro-9-undecanone
Tian, Dong; Dubois, Philippe ULg; Jérôme, Robert ULg

in Macromolecules (1997), 30(7), 1947-1954

Homopolymers of 1,4,8-trioxa[4.6]spiro-9-undecanone (TOSUO) and block copolymers of TOSUO and ε-caprolactone (ε-CL) have been synthesized with aluminum isopropoxide as an initiator in toluene at 25 °C ... [more ▼]

Homopolymers of 1,4,8-trioxa[4.6]spiro-9-undecanone (TOSUO) and block copolymers of TOSUO and ε-caprolactone (ε-CL) have been synthesized with aluminum isopropoxide as an initiator in toluene at 25 °C. The homopolymerization is first order with respect to both monomer and initiator, and the end-group analysis agrees with a coordination−insertion mechanism based on the acyl-oxygen cleavage of the TOSUO ring. Living poly(ε-caprolactone) (PCL) and poly(1,4,8-trioxa[4.6]spiro-9-undecanone) (PTOSUO) chains are very efficient macroinitiators for the polymerization of TOSUO and ε-CL, respectively, with formation of block copolymers of a narrow molecular weight distribution. Size-exclusion chromatography (SEC) and 13C-NMR confirm the blocky structure of the copolymers, in agreement with DSC, which shows two glass transitions characteristic of the amorphous phase of PCL and PTOSUO, respectively. The ethylene ketal pendent groups of the PTOSUO block have been successfully converted to ketones and hydroxyl pendent groups without scission of the polyester backbone. These new materials have potential for applications in medicine, surgery, and tissue engineering. [less ▲]

Detailed reference viewed: 185 (3 ULg)
Full Text
Peer Reviewed
See detailOn the Intercostal Muscle Compensation for Diaphragmatic Paralysis in the Dog
Brichant, Jean-François ULg; De Troyer, A.

in Journal of Physiology (1997), 500((Pt 1)), 245-53

1. Paralysis of the diaphragm in the dog is known to cause a compensatory increase in activation of the inspiratory intercostal muscles (parasternal intercostals, external intercostals, and levator costae ... [more ▼]

1. Paralysis of the diaphragm in the dog is known to cause a compensatory increase in activation of the inspiratory intercostal muscles (parasternal intercostals, external intercostals, and levator costae). The present studies were designed to assess the mechanism(s) of that compensation. 2. Complete, selective diaphragmatic paralysis was induced by injecting local anaesthetic into small silicone cuffs placed around the phrenic nerve roots in the neck. 3. Paralysis produced a decrease in tidal volume and an increase in arterial P(CO2) (P(a,CO2)). The increased hypercapnic drive was a primary determinant of the increased inspiratory intercostal activity. 4. However, paralysis also produced an increased inspiratory cranial displacement of the ribs. When this increased rib displacement was reduced to that seen before paralysis, it appeared that the increase in external intercostal and levator costae inspiratory activity was commonly greater than anticipated on the basis of the increased P(a,CO2). 5. Diaphragmatic paralysis after bilateral vagotomy also elicited disproportionate increases in inspiratory intercostal activity, thus indicating that these increases are not caused by vagal afferent inputs. 6. These observations are consistent with the idea that the intercostal muscle compensation for diaphragmatic paralysis is, in part, due to the release of an inhibition originating from the contracting diaphragm. This inhibition might arise in the diaphragmatic tendon organs. [less ▲]

Detailed reference viewed: 37 (4 ULg)
Full Text
Peer Reviewed
See detailVariations of the AP star HD 208217.
Manfroid, Jean ULg; Mathys, G.

in Astronomy and Astrophysics (1997), 320

We present a new determination of the rotation period of the Ap star HD 208217 based on photometric and magnetic measurements. The variations of this star are remarkable by the strong anharmonicity of its ... [more ▼]

We present a new determination of the rotation period of the Ap star HD 208217 based on photometric and magnetic measurements. The variations of this star are remarkable by the strong anharmonicity of its lightcurves in all colours as well as by the double wave of its mean magnetic field modulus variations. [less ▲]

Detailed reference viewed: 5 (0 ULg)
See detailLes constellations (II).
Renson, Pierre ULg

in Ciel et Terre (1997), 113

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailVieillissement de la population: données démographiques pour la région Liégeoise
Paul, I.; Gosset, Christiane ULg

in Revue Médicale de Liège (1997), 52(4), 190-2

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailStereocomplexation of sPMMA-PBD-sPMMA triblock copolymers with isotactic PMMA: 1. Thermal and mechanical properties of stereocomplexes
Yu, Jian Ming; Yu, Yi-Song; Dubois, Philippe ULg et al

in Polymer (1997), 38(9), 2143-2154

A novel thermoplastic elastomer consisting of a triblock copolymer (MBM) with outer syndiotactic poly(methyl methacrylate) (sPMMA) blocks associated to an inner polybutadiene (PBD) block has been modified ... [more ▼]

A novel thermoplastic elastomer consisting of a triblock copolymer (MBM) with outer syndiotactic poly(methyl methacrylate) (sPMMA) blocks associated to an inner polybutadiene (PBD) block has been modified by stereocomplexation with isotactic PMMA (iPMMA). Solution cast films of stereocomplexes have been analysed by thermal analysis as a function of the iPMMA/sPMMA (i/s) mixing ratio and the solvent used for the film casting. Although self-aggregation of iPMMA is currently observed, this phenomenon does not occur in solvent cast films of iPMMA with the MBM copolymers. Extent of complexation depends on the i/s mixing ratio and the casting solvent. At a constant i/s ratio, molecular weight of iPMMA has no significant effect on the extent of stereocomplexation. Thermal stability of the stereocomplexes is only affected by the casting solvent, in contrast to tensile strength which is greatly influenced by the mixing ratio of the two PMMA stereoisomers. Tensile strength is increased when increasing amounts of iPMMA are blended with a triblock copolymer of low PMMA content (e.g. 12%). In case of triblocks of high PMMA content (ca. 30% or higher), a low i/s ratio (<l/4) increases the tensile strength, whereas a high i/s mixing ratio (1/2) results in decreasing tensile strength. The same trend is observed for blends of sPMMA-polystyrene (PS)-PBD-PS-sPMMA (MSBSM) pentablock copolymers with iPMMA. [less ▲]

Detailed reference viewed: 42 (3 ULg)
Peer Reviewed
See detailLes manifestations osteo-articulaires du sujet âgé
Andre, Béatrice ULg; Ribbens, Clio ULg; Kaye, O. et al

in Revue Médicale de Liège (1997), 52(4), 270-277

Detailed reference viewed: 23 (1 ULg)
Full Text
Peer Reviewed
See detailA Positron Emission Tomography Study of Voluntarily and Electrically Contracted Human Quadriceps
Vanderthommen, Marc ULg; Depresseux, J. C.; Bauvir, Philippe ULg et al

in Muscle & Nerve (1997), 20(4), 505-7

Detailed reference viewed: 30 (4 ULg)
Full Text
Peer Reviewed
See detailSteroid Control and Sexual Differentiation of Brain Aromatase
Balthazart, Jacques ULg

in Journal of Steroid Biochemistry & Molecular Biology (1997), 61(3-6), 323-39

Brain aromatase (ARO) activity in the quail is markedly enhanced by testosterone (T). This effect only becomes detectable after several hours and reaches its maximum within a few days, which suggests ... [more ▼]

Brain aromatase (ARO) activity in the quail is markedly enhanced by testosterone (T). This effect only becomes detectable after several hours and reaches its maximum within a few days, which suggests enzymatic induction at the genomic level. This idea is reinforced by the fact that T also increases the ARO protein, as observed by immunocytochemistry (ICC) and the ARO mRNA, as measured by reverse transcriptase-polymerase chain reaction (RT-PCR). These changes can be mimicked by the administration of estrogens and therefore presumably require T aromatization. In our first test, injection of the non-steroidal ARO inhibitor, R76713 (racemic vorozole), unexpectedly revealed an increase in ARO immunoreactivity in the preoptic area (POA) of treated birds. This property of R76713 was shared by another non-steroidal inhibitor, fadrozole, but not by two steroidal inhibitors, androstatrienedione (ATD) and 4-hydroxy-androstenedione (OHA). These last two compounds markedly decreased the concentration of brain ARO as estimated by ICC. In parallel, ATD and OHA decreased ARO mRNA concentration measured by RT-PCR but vorozole and fadrozole had no effect on these concentrations in the POA, and only caused them to decrease slightly in the posterior hypothalamus. Together, these data indicate that the removal of estrogens caused by steroidal inhibitors decreases the synthesis of ARO, presumably at the transcriptional level. Additional regulatory mechanisms apparently take place after the injection of non-steroidal inhibitors and probably include increased half-life of the protein. The induction of ARO activity by steroids appears to be greater in males than in females, but this difference has been difficult to localize and confirm by assay methods. We therefore analysed by ICC the tridimensional distribution of ARO-ir neurons in the POA of males and females that were sexually mature or gonadectomized and treated with T-filled or control empty implants. Localized sex differences and effects of T were detected in this way. In particular, males had more ARO-ir cells than females in the lateral POA but a difference in the opposite direction was evident in the medial part of this area. These sex differences are largely activational (i.e. caused by the higher T levels in males) but they may also reflect organizational effects of neonatal steroids. Castration decreased ARO-ir cell numbers in the lateral POA, but increased it in the periventricular region. This anatomically specialized control by T may be mediated by three potential mechanisms that are discussed and comparatively evaluated: a migration of ARO neurons towards the ventricle after castration; a differential colocalization of ARO with estrogen receptors or a differential modulation of ARO neurons by catecholaminergic inputs. [less ▲]

Detailed reference viewed: 14 (3 ULg)
Peer Reviewed
See detailRole of Interleukin-1 Beta, Interleukin-6, and Tnf-Alpha in Intestinal Maturation Induced by Dietary Spermine in Rats
Kaouass, M.; Deloyer, Patricia; Gouders, Isabelle et al

in Endocrine (1997), 6(2), 187-94

In the present investigation, the authors aimed to evaluate the role of cytokines in intestinal postnatal maturation induced by dietary polyamines. Neonatal rats were administered either saline (8 mumol ... [more ▼]

In the present investigation, the authors aimed to evaluate the role of cytokines in intestinal postnatal maturation induced by dietary polyamines. Neonatal rats were administered either saline (8 mumol) orally. Spermine increased interleukin-1 beta (IL-1 beta), IL-6, and TNF-alpha plasma concentration. The maximum concentrations of IL-1 beta, IL-6, and TNF-alpha were, respectively, observed at 4, 4, and 8 h posttreatment. Intraperitoneal (i.p.) injection of IL-1 beta increased the specific activity of sucrase in whole small intestine, whereas the specific activities of maltase and lactase were significantly enhanced only in the jejunum. IL-6 elicited sucrase and increased maltase specific activity in the whole small intestine, but lactase specific activity was not affected. TNF-alpha had no effect on sucrase and maltase specific activity, but a slight augmentation of lactase specific activity was detected in the jejunum. Spermine and spermidine content in the intestine was increased by i.p. injection of IL-1 beta and IL-6. Corticosterone secretion was elevated by single i.p. injection of IL-1 beta, IL-6, or TNF-alpha. These findings suggest that spermine could induce postnatal intestinal development and corticosterone secretion through a cytokine-dependent mechanism. [less ▲]

Detailed reference viewed: 38 (4 ULg)
Full Text
Peer Reviewed
See detailComment je traite ... L'ostéoporose sénile
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (1997), 52(4), 267-9

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailGlycoprotein B of Bovine Herpesvirus 4 Is a Major Component of the Virion, Unlike That of Two Other Gammaherpesviruses, Epstein-Barr Virus and Murine Gammaherpesvirus 68
Lomonte, P.; Filée, Patrice ULg; Lyaku, J. R. et al

in Journal of Virology (1997), 71(4), 3332-5

This study reports that in bovine herpesvirus 4, glycoprotein B (gB) is a heterodimer and a major component of the virion, unlike gBs of Epstein-Barr virus (gp110) and murine gammaherpesvirus 68, two ... [more ▼]

This study reports that in bovine herpesvirus 4, glycoprotein B (gB) is a heterodimer and a major component of the virion, unlike gBs of Epstein-Barr virus (gp110) and murine gammaherpesvirus 68, two other gammaherpesviruses. These are new characteristics with regard to the general features of gB in the Gammaherpesvirinae subfamily. [less ▲]

Detailed reference viewed: 20 (0 ULg)
Peer Reviewed
See detailProblèmes diagnostiques, thérapeutiques et socio-économiques en oncologie gériatrique
Jerusalem, Guy ULg; Fillet, Georges ULg

in Revue Médicale de Liège (1997), 52(4), 255-7

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailAromatase Inhibition Blocks the Activation and Sexual Differentiation of Appetitive Male Sexual Behavior in Japanese Quail
Balthazart, Jacques ULg; Castagna, C.; Ball, G. F.

in Behavioral Neuroscience (1997), 111(2), 381-97

Two experiments investigated the role of estrogens in the activation and sexual differentiation of appetitive sexual behavior (ASB) in Japanese quail (Coturnix japonica) as measured by a learned social ... [more ▼]

Two experiments investigated the role of estrogens in the activation and sexual differentiation of appetitive sexual behavior (ASB) in Japanese quail (Coturnix japonica) as measured by a learned social proximity response. Injection of the aromatase inhibitor R767 13 in castrated, testosterone (T)-treated male quail completely suppressed ASB, confirming that, like consummatory sexual behavior, ASB is mediated by T aromatization. ASB is not observed in female quail, even if they are treated with T as adults. The role of embryonic estrogens in the sexual differentiation of ASB was tested by blocking estrogen synthesis in ovo. Control male and T-treated female quail deprived of estrogens during embryonic life learned the social proximity response used to assess ASB, whereas control female quail did not, despite the presence of high T. Thus, ASB is demasculinized by the action of embryonic estrogens during ontogeny as is consummatory behavior. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Peer Reviewed
See detailPulmonary Function Values in Friesian and Double-Muscled Calves During Acute Poikilocapnic Hypoxia
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1997), 44(2), 79-90

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian ... [more ▼]

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian White and Blue (BWB) breed known to develop more severe hypoxemia during exercise and respiratory diseases. Data were collected at 1 min intervals throughout the following protocol: breathing air (FIO2 = 21%), then breathing hypoxic gas mixture (FIO2 = 10%) for 5 min, and, finally, breathing air again for 5 min of recovery. Arterial blood was sampled at rest and at the 4th min of hypoxia for blood gas analysis. In HF and BWB calves, hypoxia induced a significant increase in tidal and minute volume, but did not change respiratory rate, dynamic lung compliance and total pulmonary resistance. However, with regard to their ventilation during normoxia at rest, BWB calves showed a comparatively greater rise in ventilation than HF calves during the first 4 min of hypoxia. On the contrary, by the 5th minute of hypoxia, ventilation of BWB calves declined to the normoxic level while HF calves largely sustained hyperventilation. This hypoxic ventilatory depression in BWB calves could be explained by the proportionately greater initial increase in ventilation. It was concluded that BWB calves supported this hypoxic challenge less easily than HF calves. [less ▲]

Detailed reference viewed: 45 (4 ULg)
Full Text
Peer Reviewed
See detailStudy of the Influence of Both Cyclodextrins and L-Lysine on the Aqueous Solubility of Nimesulide; Isolation and Characterization of Nimesulide-L-Lysine-Cyclodextrin Complexes
Piel, Géraldine ULg; Pirotte, Bernard ULg; Delneuville, Isabelle et al

in Journal of Pharmaceutical Sciences (1997), 86(4), 475-80

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 ... [more ▼]

Nimesulide is a nonsteroidal antiinflammatory drug that exhibits a very poor water solubility (0.01 mg.mL-1). A nimesulide-beta-cyclodextrin complex prepared according to patent application WO 94/ 02177 has an aqueous solubility of approximately 16 mg.mL-1 of nimesulide. A nimesulide-L-lysine salt has also been prepared and increases the aqueous solubility of nimesulide to approximately 5.0-7.5 mg.mL-1. The purpose of the present study was to investigate the interaction of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide. Nimesulide-L-lysine-beta- or gamma-cyclodextrin complexes were prepared by spray-drying. The inclusion of the nimesulide-L-lysine salt into the cyclodextrin cavity was confirmed by differential scanning calorimetry and proton nuclear magnetic resonance spectroscopy. These complexes offered remarkable aqueous solubility. The incorporation of nimesulide in a nimesulide-L-lysine-beta-cyclodextrin complex increased its water solubility by a factor of 10 at pH 1.5 (0.050 mg.mL-1 for the complex versus 0.005 mg.mL-1 for nimesulide), 160 at pH 6.8 (2.373 mg.mL-1 for the complex versus 0.015 mg.mL-1 for nimesulide), and 3600 in purified water (36.400 mg.mL-1 for the complex versus 0.01 mg.mL-1 for nimesulide). [less ▲]

Detailed reference viewed: 27 (6 ULg)
Full Text
Peer Reviewed
See detailProcessus expansifs non-adénomateux intra-sellaires
Rohmer, V.; Chanson, Philippe; Dupas, B. et al

in Annales d'Endocrinologie (1997), 58(1), 11-19

More than thirty types of tumors in the sellar region can mimic pituitary adenoma on, magnetic resonance imaging. When they exist, clinical manifestations are not necessarily highly contributive to ... [more ▼]

More than thirty types of tumors in the sellar region can mimic pituitary adenoma on, magnetic resonance imaging. When they exist, clinical manifestations are not necessarily highly contributive to diagnosis. Headache, visual impairment, signs of antepituitary insufficiency or possible dysmenorrhea with galactorrhea attributed to hyperprolactinemia due to compression of the dopaminergic axis are not specific and may be misleading. Clinical signs of diabetes insipidis and polyphagia are however suggestive of non-pituitary tumors. Consequently, high-resolution imaging (MRI) and sometimes particular diagnostic circumstances (post partum for hypophysitis for example, or breast cancer for metastasis) orient the diagnosis. More rarely tumor enlargement, for example in certain germ cell tumors, provides a clue. [less ▲]

Detailed reference viewed: 51 (3 ULg)
Peer Reviewed
See detailCentral pontine myelinolysis associated with acquired folate depletion
RAMAEKERS, Vincent ULg; Reul, J.; Kusenbach, G. et al

in Neuropediatrics (1997), 28(2), 126-30

After long-standing malnutrition a 15-month-old boy with signs of kwashiorkor was admitted in a moribund state with serious hyponatraemic dehydration, hypothermia, somnolence, and signs of a pontine ... [more ▼]

After long-standing malnutrition a 15-month-old boy with signs of kwashiorkor was admitted in a moribund state with serious hyponatraemic dehydration, hypothermia, somnolence, and signs of a pontine disconnection syndrome. Folic acid levels were below the detection level in the presence of normal cobalamin levels. MRI of the brain showed global volume loss and signal abnormalities on the T2-weighted images suggestive for central pontine myelinolysis (CPM). Brainstem acoustic evoked responses have remained normal. The serious metabolic and nutritional derangements required substitution of folic acid, vitamins and trace elements as well as slow correction of hyponatraemic dehydration with return of the sodium level over a period of four days. This therapeutic regimen resulted in complete neurological recovery. Follow-up MRI documented normalisation of the initial pathologic findings. The hypothesis was put forward linking the pathogenesis of CPM with the combination of folate depletion and superimposed hyponatraemic dehydration. The previously acquired folate depletion could affect normal appositional function of myelin basic protein molecules due to insufficient methylation of arginine in position 107. The subsequent development of intramyelinic edema and CPM will then be triggered by the superimposed hyponatraemic dehydration. The verification of this hypothesis requires further investigations. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailChirurgie carotidienne au-delà de 75 ans
Van Damme, Hendrik ULg; Albert, Adelin ULg; Limet, Raymond

in Revue Médicale de Liège (1997), 52(4), 237-44

Detailed reference viewed: 1 (0 ULg)
Peer Reviewed
See detailLa maladie d'Alzheimer
Salmon, Eric ULg; Georges, Michel ULg; Collette, Fabienne ULg

in Revue Médicale de Liège (1997), 52(4), 258-261

La maladie d'Alzheimer touche plus de 5% de notre population adulte, et sa prévalence augmente avec l'äge. La symptomatologie clinique permet un diagnostic de haute probabilité, mais les lésions ... [more ▼]

La maladie d'Alzheimer touche plus de 5% de notre population adulte, et sa prévalence augmente avec l'äge. La symptomatologie clinique permet un diagnostic de haute probabilité, mais les lésions histologiques de dégénérescence neurofibrillaire et les plaques séniles restent les seuls critères diagnostiques de certitude. Les recherches en biologie moléculaire visent à comprendre le mécanisme pathogène afin de pouvoir l'interrompre. En attendant, notre prise en charge est symptomatique, et le but est d'optimiser la qualité de vie du patient et de ses proches. [less ▲]

Detailed reference viewed: 39 (12 ULg)
Full Text
Peer Reviewed
See detailMild Endotoxaemia and the Inflammatory Response Induced by a Marathon Race
Camus, G.; Poortmans, J.; Nys, Monique ULg et al

in Clinical Science (1997), 92(4), 415-22

1. To address the question of whether endotoxaemia could be involved in the inflammatory response induced by long-term strenuous exercise, 18 male marathon runners [mean age 41 +/- 2 (SEM) years] were ... [more ▼]

1. To address the question of whether endotoxaemia could be involved in the inflammatory response induced by long-term strenuous exercise, 18 male marathon runners [mean age 41 +/- 2 (SEM) years] were studied. Their performance in the marathon ranged from 2 h 46 min to 4 h 42 min. 2. Four venous blood samples were drawn: at rest, just before the race (baseline); within 15 min following the completion of the marathon; after 1 h of recovery; and the morning after the race. 3. The following humoral markers of the inflammatory response to exercise were measured: polymorphonuclear myeloperoxidase (MPO), anaphylatoxin C5a (C5a), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Plasma endotoxin was measured by a sensitive and rapid chromogenic Limulus assay. All inflammatory markers were significantly increased (P < 0.001) after the race, reaching in most cases peak values in the first blood sample drawn following the completion of the marathon [MPO, 298 +/- 19 ng/ml (SEM); C5a, 1.45 +/- 0.32 ng/ml; TNF-alpha, 20 +/- 3 pg/ml; IL-6, 88 +/- 13 pg/ml] when compared with baseline [MPO, 146 +/- 16 ng/ml (SEM); C5a, 0.27 +/- 0.2 ng/ml; TNF-alpha, 12 +/- 1.5 pg/ml: IL-6, 1.0 +/- 0.5 pg/ml]. Traces of plasma endotoxin (ranging from 5 to 13 pg/ml, with one exceptionally high value of 72 pg/ml measured in one runner) were detected in seven subjects within the first hour of recovery. An ELISA method was used to determine the endogenous IgG antibodies toward a range of Gram-negative bacterial lipopolysaccharides (LPSs) of different sizes and structures. A transient decrease in certain anti-LPS activities, mainly against rough LPS, occurred in most cases in the first blood sample drawn after the race. There was no correlation between the magnitude of the inflammatory response to exercise, as assessed by the increase in blood levels of humoral markers of inflammation, and the changes in circulating endotoxin levels of anti-LPS IgG activity following the race. 4. From these results, we conclude that the mild, transient endotoxaemia detected in some of our subjects does not play a major role in the observed inflammatory response to a marathon competition. [less ▲]

Detailed reference viewed: 33 (1 ULg)
Full Text
Peer Reviewed
See detailAnterior cingulate and motor network metabolic impairment in progressive supranuclear palsy
Salmon, Eric ULg; Van der Linden, Martial ULg; Franck, Georges ULg

in Neuroimage (1997), 5(3), 173-178

Progressive supranuclear palsy is the prototype of subcortical dementia. Using positron emission tomography and statistical parametric mapping, we compared the glucose metabolic pattern obtained in this ... [more ▼]

Progressive supranuclear palsy is the prototype of subcortical dementia. Using positron emission tomography and statistical parametric mapping, we compared the glucose metabolic pattern obtained in this subcortical dementia to that observed in elderly healthy controls and in Alzheimer's disease, the prototype of cortical dementia. Progressive supranuclear palsy was characterized by a relative decrease of metabolism in anterior cingulate, adjacent supplementary motor area, precentral cortex, middle prefrontal cortex, midbrain tegmentum, globus pallidus, and ventrolateral and dorsomedial nuclei of thalamus. The data in progressive supranuclear palsy highlight predominant metabolic impairment in brain structures engaged in response selection, in attention for action, and in motor networks. [less ▲]

Detailed reference viewed: 22 (0 ULg)
Peer Reviewed
See detailQuel avenir pour l'OTAN ?
Dumoulin, André ULg

in Problèmes politiques et sociaux (1997), (782), 83

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailLithium diisopropylamide as initiator for the anionic polymerization of methacrylates
Antoun, Sayed; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1997), 30(6), 1556-1561

The anionic polymerization of a series of methacrylates, i.e. methyl methacrylate (MMA), tert-butyl methacrylate (tBuMA), (dimethylamino)ethyl methacrylate (DMAEMA), and glycidyl methacrylate (GMA), has ... [more ▼]

The anionic polymerization of a series of methacrylates, i.e. methyl methacrylate (MMA), tert-butyl methacrylate (tBuMA), (dimethylamino)ethyl methacrylate (DMAEMA), and glycidyl methacrylate (GMA), has been investigated in THF at −78 °C, by using both lithium diisopropylamide (LDA) and α-lithioethyl isobutyrate (Li-EIB) complexed with LiCl as initiators. Compared to ligated Li-EIB, which is a model for the propagating enolate in the methacrylate anionic polymerization, ligated LDA has quite a comparable initiation efficiency (>90%) and gives rise to polymers with a predictable molecular weight and a narrow molecular weight distribution (MWD < 1.1). The effect of LiCl on the MWD of poly-GMA is less pronounced compared to the other polymethacrylates. An already narrow MWD in the absence of LiCl might be accounted for by an intramolecular coordination of the ion pair by the oxirane group of the (ante)penultimate unit(s) of growing poly GMA. As a direct consequence of the well-controlled anionic polymerization of these methacrylates, pairs of them have been polymerized in a sequential way with formation of well-defined block copolymers. Actually, there is no restriction on the addition order of the comonomers, so that both types of triblocks (ABA and BAB) can be successfully synthesized. Size exclusion chromatography supports that block copolymers are not contaminated by homopolymers, at least in detectable amounts. [less ▲]

Detailed reference viewed: 41 (1 ULg)
Full Text
Peer Reviewed
See detailInvolvement of Pa/Plasmin System in the Processing of Pro-Mmp-9 and in the Second Step of Pro-Mmp-2 Activation
Baramova, E. N.; Bajou, Khalid ULg; Remacle, A. et al

in FEBS Letters (1997), 405(2), 157-62

Pro-MMP2 activation is a two-step process resulting in (1) an intermediate 64 kDa form generated by the MT1-MMP activity, and (2) a mature 62 kDa form. Addition of plasminogen to HT1080 cells cultured ... [more ▼]

Pro-MMP2 activation is a two-step process resulting in (1) an intermediate 64 kDa form generated by the MT1-MMP activity, and (2) a mature 62 kDa form. Addition of plasminogen to HT1080 cells cultured under various conditions, or to their membrane preparation, induced a complete conversion of the intermediate MMP-2 form to the mature one, and processing of pro-MMP-9. The pro-MMP-2 activation was inhibited by plasmin inhibitors and anti-uPA antibody. These results provide evidence for involvement of the PA/plasmin system in the second step of MMP-2 activation. [less ▲]

Detailed reference viewed: 4 (2 ULg)
Full Text
See detailHR 7674: a low-amplitude cepheid?
Manfroid, Jean ULg; Renson, Pierre ULg; Burnet, M.

in Information Bulletin on Variable Stars (1997), 4453

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailOptical observations of comet Hale-Bopp (C/1995 O1) at large heliocentric distances before perihelion.
Rauer, H.; Arpigny, Claude ULg; Boehnhardt, H. et al

in Science (1997), 275

The activity of comet Hale-Bopp (C/1995 O1) was monitored monthly by optical imaging and long-slit spectroscopy of its dust and gas distribution over heliocentric distances of 4.6 to 2.9 AU. The observed ... [more ▼]

The activity of comet Hale-Bopp (C/1995 O1) was monitored monthly by optical imaging and long-slit spectroscopy of its dust and gas distribution over heliocentric distances of 4.6 to 2.9 AU. The observed band intensities of the NH[SUB]2[/SUB] radical and the H[SUB]2[/SUB]O[SUP]+[/SUP] ion cannot be explained by existing models of fluorescence excitation, warranting a reexamination of the corresponding production rates, at least at large heliocentric distances. Comparing the production rate of the CN radical to its proposed parent, HCN, shows no evidence for the need of a major additional source for CN in Hale-Bopp at large heliocentric distances. The dust and CN production rates are consistent with a significant amount of sublimation occurring from icy dust grains surrounding Hale-Bopp. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Full Text
See detailLe transsexualisme : considérations générales et prise en charge
Michel, Aude; Mormont, Christian ULg

in Revue Médicale de Liège (1997), 52(3), 163-168

Detailed reference viewed: 16 (0 ULg)
Peer Reviewed
See detailLa famille des peptides natriurétiques
Damas, Jacques ULg; Liégeois, Jean-François ULg

in Revue Médicale de Liège (1997), 52(3), 169-73

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailPrediction of Bone Loss Rate in Healthy Postmenopausal Women
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Collette, Julien ULg et al

in Calcified Tissue International (1997), 60(3), 261-4

Prevention of fractures is the only way to drastically reduce osteoporosis-related health expenditures. In order to optimize the cost/benefit ratio of a strategy of prevention, it is essential to identify ... [more ▼]

Prevention of fractures is the only way to drastically reduce osteoporosis-related health expenditures. In order to optimize the cost/benefit ratio of a strategy of prevention, it is essential to identify, as early as possible, women who will develop fractures later in their life. Therefore, and since postmenopausal bone loss is an asymptomatic process, screening procedures should detect, at the time of the menopause, women whose postmenopausal bone loss is higher than the mean, and will, a couple of years later, exhibit a low mineral content and a subsequent high risk for fractures. For 3 years we have followed a cohort of 92 healthy women who had undergone menopause less than 36 months previously. By a multivariate discriminant analysis based on the differences in lumbar bone density, assessed by dual photon absorptiometry, and in a few routine biochemical parameters (serum phosphorus, estrone, androstenedione, and urine calcium) observed during the first 6 months of the study, we have been able to correctly predict the rate of spinal bone loss, observed at the end of the 3 years, in 76% of the subjects. All of the women who presented a bone loss higher than 10% over the 3 years were correctly isolated by our discriminant functions after 6 months of follow-up. We conclude that a measurement of lumbar bone mineral density coupled with a few routine biochemical determinations, repeated twice at a 6-month interval in healthy postmenopausal women, can isolate 100% of postmenopausal "fast bone losers" with an overall specificity of 76%. [less ▲]

Detailed reference viewed: 22 (5 ULg)
Peer Reviewed
See detailVentilatory Effects of the Single-Breath Co2 Test, Compared with Eructation, in Cattle
Rollin, Frédéric ULg; Desmecht, Daniel ULg; Genicot, B. et al

in American Journal of Veterinary Research (1997), 58(3), 310-6

OBJECTIVE: To assess the peripheral chemoreceptor-induced ventilatory response to single tidal-breath CO2 (SB CO2) tests, compared with eructations, in 2 breeds of calves. ANIMALS: 13 conscious unsedated ... [more ▼]

OBJECTIVE: To assess the peripheral chemoreceptor-induced ventilatory response to single tidal-breath CO2 (SB CO2) tests, compared with eructations, in 2 breeds of calves. ANIMALS: 13 conscious unsedated Holstein-Friesian and 8 Belgian White and Blue hypermuscled calves. PROCEDURE: An SB of +/- 50% CO2 in equal parts of O2 and N2 was inhaled. Ventilatory response was determined from the increase in ventilation (delta Ve) during the first 20 seconds after the test breath or eructation and from the difference in end-tidal PCO2 between the stimulus and preceding control breaths. RESULTS: Because no difference was found between the 2 breeds of calves, all data were pooled. The increase in Ve peaked during the fifth breath after the SB CO2 test on average, corresponding to a delay of 12.4 seconds. The SB CO2 responses ranged from 0.037 to 0.151 L/min.mm of Hg.m2, with a mean +/- SD of 0.082 +/- 0.032 L/min.mm of Hg.m2 for all calves. The SB CO2 tests, similar to eructations, modified the breathing pattern significantly and in the same direction, by principally shortening expiratory time and increasing mean inspiratory flow. After eructations, Ve peak increase was more important for lower difference in end-tidal PCO2 between the stimulus and preceding control breaths and took place more rapidly than after SB CO2 tests. Accordingly, eructation responses were more marked than SB CO2 responses and averaged 0.925 +/- 0.276 L/min.mm of Hg.m2. CONCLUSIONS AND CLINICAL RELEVANCE: In cattle, the pattern of breathing and ventilation under basal conditions is characterized by a cyclic variability coupled to eructation. [less ▲]

Detailed reference viewed: 28 (1 ULg)
Peer Reviewed
See detailImpact of Percutaneous Oestradiol Gels in Postmenopausal Hormone Replacement Therapy on Clinical Symptoms and Endometrium
Foidart, Jean-Michel ULg; Beliard, Aude ULg; Hedon, B. et al

in British Journal of Obstetrics & Gynaecology (1997), 104(3), 305-10

OBJECTIVE: To compare the effects on endometrium, climacteric symptoms and the menstrual cycle, and the clinical and biological tolerance of two percutaneous oestradiol gels used as hormone replacement ... [more ▼]

OBJECTIVE: To compare the effects on endometrium, climacteric symptoms and the menstrual cycle, and the clinical and biological tolerance of two percutaneous oestradiol gels used as hormone replacement therapy. DESIGN: A large open randomised multicentre study. SETTING: France and Belgium. PARTICIPANTS: Two-hundred and fifty-four women with an intact uterus and who had experienced a natural menopause received either Oestrogel (n = 126) or Estreva, a new formulation of oestradiol gel (n = 128), (1.5 mg of oestradiol/day) for the 24 first days of each calendar month during six consecutive months. Nomegestrol acetate (Lutenyl), a norprogesterone derivative, was administered (5 mg/day) from day 11 to day 24 of each oestradiol cycle. MAIN OUTCOME MEASURES: Examination of endometrial biopsies taken before treatment and between days 18 and 24 of the last treatment cycle, climacteric symptoms assessed using a modified Kupperman index, control of menstrual cycle evaluated by diary cards, and clinical and biological tolerance. RESULTS: Both treatments lowered the frequency and intensity of hot flushes and the global Kupperman index. 96% of the cycles were followed by withdrawal bleeding. Breakthrough bleeding or spotting resulted in premature discontinuation of treatment in one volunteer. Mastodynia occurred in 20 women and contributed to the premature termination of treatment in three of them. Endometrial biopsies taken at the end of treatment showed identical histologies in both groups, with a secretory pattern in the majority of women, and absence of hyperplasia. CONCLUSIONS: This trial confirmed that, when the two oestradiol gels tested were administered cyclically with nomegestrol acetate to postmenopausal women, they were well tolerated, effective and suitable for the treatment of oestrogen deficiency syndrome. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailExpression of the 67 Kd Laminin Receptor in Human Cervical Preneoplastic and Neoplastic Squamous Epithelial Lesions: An Immunohistochemical Study
al-Saleh, W.; Delvenne, Philippe ULg; van den Brule, F. A. et al

in Journal of Pathology (The) (1997), 181(3), 287-93

Interactions of cancer cells with laminin play a critical role during the progression of solid malignant tumours. Increased expression of the 67 kD laminin receptor (67LR), one of the several laminin ... [more ▼]

Interactions of cancer cells with laminin play a critical role during the progression of solid malignant tumours. Increased expression of the 67 kD laminin receptor (67LR), one of the several laminin binding proteins, is associated with the invasive and metastatic capacity of various types of cancer, including breast, colon, ovary, lung, and endometrial carcinoma. In this study, 67LR expression was analysed in a series of cervical biopsy specimens including 16 normal cervical tissues, 36 low-grade squamous intraepithelial lesions (SILs), 24 high-grade SILs, and 11 invasive carcinomas. Detection of the 67LR was performed using immunoperoxidase staining and the monoclonal antibody MLuC5 which specifically recognizes the 67LR. Immunostaining of the 67LR was correlated with human papillomavirus (HPV) type detected by in situ hybridization and with proliferative activity of the lesion determined by immunohistochemistry with the MIB-1 monoclonal antibody, specific for the Ki67 antigen. Increased expression of the 67LR was correlated with the histological severity of the lesions, with the strongest immunoreactivity being found in invasive carcinomas. Significant differences in 67LR expression were found between normal cervical epithelium and high-grade SILs (P < 0.05, non-parametric Mann-Whitney test) or invasive carcinomas (P < 0.001), as well as between low- or high-grade SILs and invasive carcinoma (P < 0.01 and P < 0.05, respectively). Ki67 antigen expression also increased with the severity of the lesions. There was a positive correlation for each type of lesion between expression of the 67LR and of the Ki67 antigen. No specific relationship was found between 67LR or Ki67 antigen immunostaining and HPV type detected in SILs, segregated into low-grade and high-grade lesions. These data add weight to the evidence that increased expression of the 67LR is a consistent, but not sufficient feature of the invasive and metastatic phenotype and suggest that high expression of the 67LR might be associated with both more proliferative and more aggressive cervical (pre)neoplastic lesions. [less ▲]

Detailed reference viewed: 31 (1 ULg)
Full Text
Peer Reviewed
See detailAt Least Three Subdomains of V-Erba Are Involved in Its Silencing Function
Busch, Kerstin; Martin, Bernd; Baniahmad, Aria et al

in Molecular Endocrinology (1997), 11(3), 379-89

Several members of the thyroid hormone receptor (TR) family are able to switch from a transcriptional repressor to a transcriptional activator upon binding of their ligand. The oncogene v-erbA is a ... [more ▼]

Several members of the thyroid hormone receptor (TR) family are able to switch from a transcriptional repressor to a transcriptional activator upon binding of their ligand. The oncogene v-erbA is a variant form of the TR unable to bind hormone and thus acts as a constitutive repressor. We demonstrate, using fusion proteins between the DNA-binding domain of the yeast factor GAL4 and the silencing domains of v-erbA and TR beta, that point mutations in three different regions severely affect their repression function. Furthermore, the three regions, each as an inactive fusion protein with the GAL4 DNA-binding domain, restore silencing activity when assembled on the same promoter. These observations define at least three silencing subdomains, SSD1-SSD3, which are involved in the silencing function of v-erbA. We propose a model in which full silencing activity is brought about by the combined interaction of each silencing subdomain with corepressors and/or basal transcription factors. [less ▲]

Detailed reference viewed: 18 (6 ULg)
Peer Reviewed
See detailRILEM Recommendations : Part 6 – Thermal Strain
Schneider, Ulrich; Schwesinger, P.; Debicki, Gérard et al

in Materials and Structures (1997)

Detailed reference viewed: 42 (1 ULg)
Peer Reviewed
See detailPhysicochemical causes for the microstructure of melt-textured YBa2Cu3O7-delta/Y2BaCuO5 composites
Vandewalle, Nicolas ULg; Cloots, Rudi ULg; Ausloos, Marcel ULg

in Superconductor Science and Technology (1997), 10(3), 123-133

We report semiquantitative results for a physicochemical model intended to describe the multigrain growth of YBa2Cu3O7-deltaN2BaCuO5 (123/211) composites under isothermal undercooling. This model takes ... [more ▼]

We report semiquantitative results for a physicochemical model intended to describe the multigrain growth of YBa2Cu3O7-deltaN2BaCuO5 (123/211) composites under isothermal undercooling. This model takes into account various ingredients supposed to be controlling the growth of such superconducting compounds, i.e. the presence of secondary phases. Moreover, a possible dynamical interaction between the growing 123 grains and the 211 solid particles is also included. The numerical investigations were performed for a model bivariate-like 211 particle distribution. The complete chemical dissolution of the small particles is allowed but the large ones are only partially dissolved in the first step which can be followed when chemically possible by a complete dissolution. The model is restricted to a two-dimensional square lattice. Various microstructural morphologies are obtained as a function of the initial composition of the melt and the initial size distributions of the 211 particles. Results are in quite good agreement with experimental observations. The quantity of 123 phase is predicted depending on the initial conditions. The optimal situation when a minimum fraction of liquid phase segregates at the gain boundaries is found to occur for 20 % excess of 211 phase in the initial melt. [less ▲]

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailSepsis and Serum Cytokine Concentrations
Damas, Pierre ULg; Canivet, Jean-Luc ULg; de Groote, Donat et al

in Critical Care Medicine (1997), 25(3), 405-12

OBJECTIVE: To look for relationships between the classification of sepsis and plasma cytokine concentrations. DESIGN: Prospective, consecutive entry study of patients meeting severe sepsis criteria and ... [more ▼]

OBJECTIVE: To look for relationships between the classification of sepsis and plasma cytokine concentrations. DESIGN: Prospective, consecutive entry study of patients meeting severe sepsis criteria and having bacteriologically documented infections. SETTING: University hospital, surgical intensive care unit. PATIENTS: Fifty consecutive patients developing severe sepsis or septic shock between December 1991 and December 1993. MEASUREMENTS AND MAIN RESULTS: Concentrations of tumor necrosis factor, interleukin (IL)-6, IL-8, and leukemia inhibitory factor were measured by immunoradiometric assay in the plasma of patients as soon as they developed severe sepsis or septic shock. Septic shock patients were divided into three groups in a blinded fashion (i.e., without knowing the results of the concentrations of cytokines), according to the presence of sustained hyperlactacidemia and to the rapidity of the onset of sepsis. Peak concentrations of all cytokines were statistically different between severe sepsis and septic shock patients. This finding was almost exclusively due to the data from patients with rapid onset of septic shock, who demonstrated very high but transient cytokine concentrations. Septic shock patients may thus have different profiles in the time course of their cytokine concentrations. The transient, high peak concentrations of cytokines were also related to transient leukopenia. Among the cytokines measured, IL-8 appeared to be the one that correlated best with lactacidemia, the presence of disseminated intravascular coagulation, severe hypoxemia, the Acute Physiology and Chronic Health Evaluation II score, and mortality rate. CONCLUSIONS: According to the profiles of the cytokines, septic shock patients do not represent a homogeneous population. These profiles should be described in order to distinguish between patients, and the profiles may be useful to identify those patients susceptible to new therapies. [less ▲]

Detailed reference viewed: 34 (4 ULg)
Full Text
Peer Reviewed
See detailLe cas clinique du mois. Ostéoporose et beta-thalassémie
Halkin, V.; Francotte-Lempereur, N.; Debrun, A. et al

in Revue Médicale de Liège (1997), 52(3), 138-41

Detailed reference viewed: 20 (2 ULg)
Peer Reviewed
See detailTraitement chirurgical de l'insuffisance tricuspide. L'annuloplastie de Carpentier
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1997), 52(3), 159-62

Detailed reference viewed: 27 (0 ULg)
Peer Reviewed
See detailInfluence of Age and Breed on the Binding of Oxygen to Red Blood Cells of Bovine Calves
Gustin, Pascal ULg; Detry, B.; Robert, Alain ULg et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1997), 82(3), 784-90

The influence of somatic growth and genetic selection on the whole blood oxygen equilibrium curve (OEC) was measured under standard conditions in double-muscled and dairy calves during their first 3 mo of ... [more ▼]

The influence of somatic growth and genetic selection on the whole blood oxygen equilibrium curve (OEC) was measured under standard conditions in double-muscled and dairy calves during their first 3 mo of life. Crossbreed animals were also investigated. Hemoglobin, 2,3-diphosphoglycerate (DPG), Cl, and Pi concentrations were also measured. The percentage of fetal hemoglobin (HbF) was determined. The influence of exogenous Cl, Pi, and pH on the OEC was also assessed. The PO2 at 50% hemoglobin saturation (P50) increased during somatic growth, probably because of the increase in DPG recorded in double-muscled neonates and to the progressive disappearance of HbF in both breeds. The oxygen exchange fraction (OEF%) was used to assess the combined influence of the OEC shift and OEC shape changes on blood oxygen desaturation under standard conditions, when the PO2 decreases within a physiological range. The OEF% showed an increase during the first month, then a stabilization. The effects of Cl, Pi, and pH in Friesian calves were similar as in adult cattle. Double-muscled neonates had a lower P50, OEF% values, and DPG concentrations and higher hemoglobin and Cl concentrations than Friesian neonates. The Pi concentration and the percentage of HbF were similar in both breeds. The pH and the Cl concentration had significantly less effect on the OEC in double-muscled than in Friesian calves. Crossbreed animals exhibited intermediate parameter values, between those recorded for double-muscled and Friesian calves. All differences between breeds progressively disappeared during the first month. These data show that blood function changes markedly in calves during the first month of life and that genetic selection can alter blood function. [less ▲]

Detailed reference viewed: 37 (10 ULg)
Full Text
See detailQoS specification of ODP binding objects
Février, Arnaud; Najm, Elie; Leduc, Guy ULg et al

in Telektronikk (1997), 93(1), 42-49

We present a QoS oriented notation suitable for the ODP framework. In particular, we focus on a computational view of objects: we consider systems described as configurations of interacting objects and we ... [more ▼]

We present a QoS oriented notation suitable for the ODP framework. In particular, we focus on a computational view of objects: we consider systems described as configurations of interacting objects and we deal with two types of communications: message passing and flows. In message passing, signals (from one object to another) are conveyed through the (implicit) underlying infrastructure. This form of interaction is suitable for client/server applications where no strong real time or ordering constraints are needed from the communication infrastructure. In contract, in a flow type of communication, signals are conveyed through third party (binding) objects that may be explicitly called for in order to ensure specific QoS requirements needed by specific applications. A building blocks approach for the formal specification of binding objects in the ODP computational model is presented. The formal notation that is used is based on LOTOS extended with two features - real time and gate passing. These features are among the extensions that are currently studied in the ISO standardisation Formal Description Techniques group. We apply our building blocks approach to the specification of a multicast, multimedia binding object. [less ▲]

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailA novel biodegradable and biocompatible ceramer prepared by the sol-gel process
Tian, Dong; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Chemistry of Materials (1997), 9(4), 871-874

Detailed reference viewed: 38 (12 ULg)
Peer Reviewed
See detailComment j'explore ... Sur le plan coronarien, un patient avant chirurgie non cardiaque
Hoffer, E.; Pierard, Luc ULg

in Revue Médicale de Liège (1997), 52(3), 178-82

Detailed reference viewed: 2 (0 ULg)
Peer Reviewed
See detailAttitudes obstétricales: Consensus de Département ULg. Document des cours de troisième cycle, octobre 96
Biquet, G.; Brichant, Jean-François ULg; Dewandre, Pierre-Yves et al

in Revue Médicale de Liège (1997), 52(3), 142-8

Detailed reference viewed: 141 (20 ULg)
Full Text
See detailEstimating Systematic Risk in the Presence of Thin Trading and Conditional Heteroscedasticity
Corhay, Albert ULg; Tourani Rad, Alireza; Urbain, Jean-Pierre

in In The Money (1997), 2

Detailed reference viewed: 14 (4 ULg)
Peer Reviewed
See detailCorrelation between Bronchoalveolar Lavage (Bal) Fluid Cell Lysate Histamine Content and Bal Fluid Eosinophil Count in Atopic and Nonatopic Asthmatics
Louis, Renaud ULg; Van Tulder, L.; Poncelet, M. et al

in International Archives of Allergy & Immunology (1997), 112(3), 309-12

We have compared the bronchoalveolar lavage fluid (BAL) cellular composition and the BAL cell lysate histamine content (fluorometric assay) in 28 stable mild to moderate asthmatics (atopic n = 18 and ... [more ▼]

We have compared the bronchoalveolar lavage fluid (BAL) cellular composition and the BAL cell lysate histamine content (fluorometric assay) in 28 stable mild to moderate asthmatics (atopic n = 18 and intrinsic n = 10) and 11 control subjects. When compared to control subjects, the whole group of asthmatics had a higher proportion of BAL eosinophils (p < 0.01) and metachromatic cells (p < 0.05). The BAL cell lysate histamine was increased in atopic (p < 0.05) and intrinsic asthmatics (p < 0.05) in comparison with control subjects. In the whole group of asthmatics, the BAL cell lysate histamine content correlated with the percentage of BAL eosinophils (r = 0.58, p < 0.01). This relationship was significant in both atopic (r = 0.48, p < 0.05) and intrinsic (r = 0.70, p < 0.05) asthmatics. For the whole group of asthmatics, both the BAL cell lysate histamine and the percentage of BAL eosinophils inversely correlated with the percent predicted FEV1 (r = -0.42, p < 0.05; r = -0.51, p < 0.05). We conclude that an increased BAL cell lysate histamine content correlates with airway eosinophilic infiltration and lung function impairment in mild to moderate atopic and intrinsic asthmatics. This suggests that BAL mast cells play a key role in recruiting eosinophils in the airways of asthmatics irrespective of the presence of an atopic status. [less ▲]

Detailed reference viewed: 20 (2 ULg)
See detailLes Accords de Coopération en matière d’objectifs budgétaires
Husson, Jean-François ULg

in Bulletin de documentation du Ministère des Finances (1997), (2), 183-214

This articles reviews the mechanisms of budgetary agreements between federal and federated entities in Belgium, in the context of the measures taken to reach the "Maastricht-criteria" and the ensuing ... [more ▼]

This articles reviews the mechanisms of budgetary agreements between federal and federated entities in Belgium, in the context of the measures taken to reach the "Maastricht-criteria" and the ensuing targets set at the European level. [less ▲]

Detailed reference viewed: 23 (5 ULg)
Full Text
Peer Reviewed
See detailSequential successful surgical management of extracranial internal carotid stenosis and ipsilateral intracranial aneurysm. Case reports.
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Desiron, Quentin ULg et al

in Vascular Surgery (1997), 31

The coexistence of extracranial internal carotid stenosis and ipsilateral intracranial aneurysm is a rare event whose management is controversial. Theoretically, the correction of a significant stenosis ... [more ▼]

The coexistence of extracranial internal carotid stenosis and ipsilateral intracranial aneurysm is a rare event whose management is controversial. Theoretically, the correction of a significant stenosis of the extracranial internal carotid may lead to an increase in the downstream pressure in the intracranial carotid, and may consequently increase the risk of rupture of the ipsilateral aneurysm. Moreover, dramatic increase of blood pressure is not uncommon after carotid endarterectomy, and may promote aneurysmal rupture. Intracranial surgical correction of a hypoperfused aneurysm down to extracranial carotid stenosis should carry an increased risk of inadequate cerebral flow during procedure, and unspecific postoperative stimulation of platelets aggregation and coagulation may complete obstruction of a subtotal carotid stenosis. We report the cases of two patients successfully treated by a two-stage surgical procedure. In a first step, the intracerebral aneurysms were controlled and electively excluded by clipping. In a second step, carotid endarteriectomies were performed some days later without any neurological complications. Postoperative recoveries were uneventful and six months after these surgical procedures, clinical examination of both patients did not reveal any worsening of the preoperative neurological status. [less ▲]

Detailed reference viewed: 28 (5 ULg)
Full Text
Peer Reviewed
See detailMicrocephaly, muscular build, rhizomelia, and cataracts: Description of a possible recessive syndrome and some comments on the use of electronic databases in syndromology
Verloes, Alain ULg; Lesenfants, S.; Misson, Jean-Paul ULg et al

in American Journal of Medical Genetics (1997), 68(4), 455-60461

We report on a 7-year-old boy born of consanguineous parents with severe microcephaly (-5 SD) but borderline intelligence, juvenile cataract, muscular build, rhizomelic shortness of limbs predominantly of ... [more ▼]

We report on a 7-year-old boy born of consanguineous parents with severe microcephaly (-5 SD) but borderline intelligence, juvenile cataract, muscular build, rhizomelic shortness of limbs predominantly of femora, advanced bone age, and micropenis. This combination of signs appears unique and may represent an undescribed, possibly autosomal recessive MCA syndrome. The use of LDDB and POSSUM in the workup of such "new syndromes" is reviewed. Three search strategies are discussed: single rare sign browsing, best combinatory fit using an array of key words, and combined rare signs scan. Pitfalls in the use of such databases and the some problems raised by inconsistent/ incomplete encoding in those two popular, highly useful syndromology retrieval systems are discussed. [less ▲]

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailAbility of PMMA to Improve the PC/PVDF interfacial Adhesion
Moussaif, Noureddine; Maréchal, Philippe; Jérôme, Robert ULg

in Macromolecules (1997), 30(3), 658-659

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailEnzymes from Cold-Adapted Microorganisms. The Class C Beta-Lactamase from the Antarctic Psychrophile Psychrobacter Immobilis A5
Feller, Georges ULg; Zekhnini, Z.; Lamotte-Brasseur, J. et al

in European Journal of Biochemistry (1997), 244(1), 186-91

A heat-labile beta-lactamase has been purified from culture supernatants of Psychrobacter immobilis A5 grown at 4 degrees C and the corresponding chromosomal ampC gene has been cloned and sequenced. All ... [more ▼]

A heat-labile beta-lactamase has been purified from culture supernatants of Psychrobacter immobilis A5 grown at 4 degrees C and the corresponding chromosomal ampC gene has been cloned and sequenced. All structural and kinetic properties clearly relate this enzyme to class C beta-lactamases. The kinetic parameters of P. immobilis beta-lactamase for the hydrolysis of some beta-lactam antibiotics are in the same range as the values recorded for the highly specialized cephalosporinases from pathogenic mesophilic bacteria. By contrast, the enzyme displays a low apparent optimum temperature of activity and a reduced thermal stability. Structural factors responsible for the latter property were analysed from the three-dimensional structure built by homology modelling. The deletion of proline residues in loops, the low number of arginine-mediated H-bonds and aromatic-aromatic interactions, the lower global hydrophobicity and the improved solvent interactions through additional surface acidic residues appear to be the main determinants of the enzyme flexibility. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailDiazepam-Insensitive Gabaa Receptors on Postnatal Spiral Ganglion Neurones in Culture
Malgrange, Brigitte ULg; Rigo, Jean-Michel; Lefebvre, Philippe ULg et al

in Neuroreport (1997), 8(3), 591-6

Using dissociated spiral ganglion cell cultures obtained from 3-day-old rat cochlea, we investigated the response of auditory neurones to gamma-aminobutyric acid (GABA) using patch-clamp techniques. In ... [more ▼]

Using dissociated spiral ganglion cell cultures obtained from 3-day-old rat cochlea, we investigated the response of auditory neurones to gamma-aminobutyric acid (GABA) using patch-clamp techniques. In our recording conditions, GABA elicited inward currents in > 95% of the neurones which reversed around 0 mV. Similar inward currents were measured using isoguvacin, a specific agonist of GABAA receptors. GABA-gated currents were reversibly inhibited by the channel blocker picrotoxin and the GABA competitive antagonist bicuculline. These functional GABAA receptors are characterized by an insensitivity to benzodiazepines and a relatively high sensitivity to beta-carbolines and barbiturates. These results show that the GABAA receptor pharmacological properties of spiral ganglion neurones are close to those of cerebellar granule cells. [less ▲]

Detailed reference viewed: 61 (9 ULg)
Full Text
Peer Reviewed
See detailRing-Opening Polymerization of 1,4,8-Trioxaspiro[4.6]-9-undecanone: A new Route to Aliphatic Polyesters Bearing Functional Pendent Groups
Tian, Dong; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Macromolecules (1997), 30(3), 406-409

A straightforward and very efficient pathway has been reported for the synthesis of a functional derivative of ε-caprolactone, i.e. 5-ethylene ketal ε-caprolactone. This new monomer has been ... [more ▼]

A straightforward and very efficient pathway has been reported for the synthesis of a functional derivative of ε-caprolactone, i.e. 5-ethylene ketal ε-caprolactone. This new monomer has been homopolymerized and copolymerized with ε-caprolactone in a well-controlled manner, strongly suggesting absence of any side reactions. Deacetalization of the polyester chains is complete and reduction of the ketone groups into hydroxyl groups as well. No chain scission is observed to occur in the course of these two derivatization reactions. Thus, aliphatic polyesters bearing either ketone pendent groups or hydroxyl pendent groups can be easily prepared, which raises new application prospects. These materials proved to be easily redispersed in an aqueous medium. They form stable colloidal nanodispersions (e.g. 100 nm). These suspensions are stable more than 48 h at room temperature and may be viewed as potential drug colloidal vectors with a core−shell like structure. Different types of reactive groups on the surface of these nanoparticulate vectors are indeed available to the binding of species selected for molecular recognition and drug targeting. For instance, the well-known reactivity of ketones toward primary amines is a direct route to attach peptides onto biodegradable and biocompatible aliphatic polyesters. Poly(ε-caprolactone) with hydroxyl groups reactive toward triethylaluminum provides a macroinitiator for lactone and lactide polymerization, so that biodegradable and biocompatible functional comb, graft, and dendritic aliphatic polyesters can now be synthesized. [less ▲]

Detailed reference viewed: 23 (5 ULg)
See detailLes constellations (I).
Renson, Pierre ULg

in Ciel et Terre (1997), 113

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailSub-arcsecond imaging and spectroscopy of the radio-loud highly polarized quasar PKS 1610-771.
Courbin, F.; Hutsemekers, Damien ULg; Meylan, G. et al

in Astronomy and Astrophysics (1997), 317

We report on imaging and spectroscopic observations of the radio-loud, highly polarized quasar PKS 1610-771 (z=1.71). Our long-slit spectroscopy of the companion 4.55" NW of the quasar confirms the ... [more ▼]

We report on imaging and spectroscopic observations of the radio-loud, highly polarized quasar PKS 1610-771 (z=1.71). Our long-slit spectroscopy of the companion 4.55" NW of the quasar confirms the stellar nature of this object, so ruling out the previously suspected gravitationally lensed nature of this system. PKS 1610-771 looks fuzzy on our sub-arcsecond R and I images and appears located in a rich environment of faint galaxies. Possible magnification, without image splitting of the quasar itself, by some of these maybe foreground galaxies cannot be excluded. The continuum fuzz (made of the closest two objects, viz. A and D) is elongated in a direction orthogonal to the E vector of the optical polarization, as in high-redshift radio-galaxies. The spectrum of PKS 1610-771 appears strongly curved, in a convex way, with a maximum of intensity at ~7,600Å (2,800AÅ rest frame), possibly indicating a strong ultraviolet absorption by dust. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Peer Reviewed
See detailLa dépense énergétique chez l'homme
Bustin, F.; Pestieau, S. R.; Paquot, Nicolas ULg et al

in Revue Médicale de Liège (1997), 52(2), 101-4

Detailed reference viewed: 7 (1 ULg)
Peer Reviewed
See detailMitogen-Activated Lymphocytes: A Good Model for Characterising Lung Cyp1a1 Inducibility
Lambert, Vincent ULg; Todaro, Anna ULg; Kremers, Pierre ULg et al

in European Journal of Epidemiology (1997), 13(2), 177-83

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility ... [more ▼]

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility factor, generally evaluated on mitogen-activated lymphocytes after PAH induction, represents correctly the lung situation. Optimal experimental conditions were determined for evaluating, on both lymphocytes and lung tissue explants, the inducibility factor, defined as the ratio of EROD activity (CYP1A1-specific) to cytochrome c reductase activity (unaffected by PAH induction). Paired results for lymphocytes and lung tissue samples from 10 lung cancer patients were compared. A good correlation was observed between lymphocyte and lung tissue inducibilities (R = 0.809; p = 0.005). In conclusion, mitogen-activated lymphocyte inducibility is indicative of lung tissue inducibility and constitutes a good marker for evaluating individual PAH inducibilities. [less ▲]

Detailed reference viewed: 22 (2 ULg)
Peer Reviewed
See detail"Pont a la transplantation" par ventricules pulsatiles de Pierce-Donachy (Thoratec)
Defraigne, Jean-Olivier ULg; DETRY, Olivier ULg; Chevolet, C. et al

in Revue Médicale de Liège (1997), 52(2), 110-5

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailDiagnostic Value of Exercise Electrocardiography and Angina after Coronary Artery Stenting. Benestent Study Group
Legrand, Victor ULg; Raskinet, B.; Laarman, G. et al

in American Heart Journal (1997), 133(2), 240-8

To determine whether metallic stent implantation within a coronary artery modifies the accuracy of angina or exercise test results in predicting stenosis, we studied 172 patients assigned to stent ... [more ▼]

To determine whether metallic stent implantation within a coronary artery modifies the accuracy of angina or exercise test results in predicting stenosis, we studied 172 patients assigned to stent implantation and 153 patients assigned to balloon angioplasty enrolled in the Benestent trial comparing de novo stenting with conventional balloon angioplasty. Sensitivity and specificity curves were constructed for the prediction of percentage diameter stenosis and minimal lumen diameter. Receiver-operator curves were constructed for comparison of diagnostic accuracy. Identical exercise load and duration were achieved in the two groups, despite a better angiographic result in patients treated with a stent. Similarly, the diagnostic accuracy of clinical symptoms or exercise test results as a function of the angiographic results were similar in patients with and patients without a stent. The intersection points of the sensitivity and specificity curves for recurrent angina or ST-segment depression were 72% to 77%. The corresponding cut-off points for percentage diameter stenosis were, respectively, 52% and 50% for patients with and without a stent (1.35 and 1.50 mm for minimal lumen diameter). We conclude that the presence of an intracoronary stent does not affect the diagnostic accuracy of recurrent angina or exercise-induced ST depression in predicting residual stenosis. We also conclude that exercise tolerance is similar after balloon angioplasty, with or without stenting, despite a better angiographic outcome in the group receiving a stent, suggesting a minimal threshold beyond which the patient is no longer at risk for ischemia during exercise. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailCardiac Risk Assessment before Vascular Surgery: A Prospective Study Comparing Clinical Evaluation, Dobutamine Stress Echocardiography, and Dobutamine Tc-99m Sestamibi Tomoscintigraphy
VAN DAMME, Hendrik ULg; Pierard, Luc ULg; Gillain, Daniel ULg et al

in Cardiovascular Surgery (1997), 5(1), 54-64

Preoperative evaluation for cardiac risk assessment before peripheral vascular surgery remains controversial. Between January and June 1994, a prospective open study was carried out in 156 patients ... [more ▼]

Preoperative evaluation for cardiac risk assessment before peripheral vascular surgery remains controversial. Between January and June 1994, a prospective open study was carried out in 156 patients scheduled for elective vascular procedures (63 carotid endarterectomies, 34 abdominal aortic aneurysms, 29 aortoiliac and 30 infrainguinal reconstructions) to compare the ability of clinical data, dobutamine stress echocardiography, and dobutamine Tc-99m sestamibi tomoscintigraphy to predict postoperative cardiac events. Pharmacological stress testing consisted of incremental dobutamine infusion (+/-1 mg atropine to achieve 85% of age-predicted maximal heart rate, with continuous echocardiographic monitoring, and injection of Tc-99m sestamibi after dobutamine infusion). Dobutamine echocardiography was abnormal in 36 patients (worsening resting wall motion abnormality in 11; new induced wall motion abnormality in 25). Dobutamine Tc-99m sestamibi tomoscintigraphy revealed a reversible perfusion defect in 34 patients, indicating the presence of myocardial ischaemia. As a result, eight patients underwent myocardial revascularization (n = 5) or the proposed operation was cancelled (n = 3). In the remaining 142 vascular procedures, there were eight (5.6%) adverse cardiac events: three myocardial infarctions (two fatal), three prolonged myocardial ischaemia, one acute congestive heart failure and one sustained ventricular arrhythmia in the post operative period. Univariate analysis selected unstable angina (relative risk (RR) 11.6), previous congestive heart failure (RR 6.4), Detsky's score of > or = 15 (RR 3.0), positive dobutamine stress echocardiography (RR 3.7), and positive dobutamine tomoscintigraphy (RR 7.4) as significant predictors of postoperative cardiac events. In patients without clinical markers of coronary artery disease (n = 66), non-invasive cardiac testing did not predict cardiac complications (n = 2; one prolonged myocardial ischaemia; one infarction). In the subset of 76 patients with definite clinical or electrocardiographic evidence of ischaemic heart disease, dobutamine stress testing provided additional information, and optimized risk stratification: five of six patients who suffered a cardiac complication had a pathologic dobutamine stress test. Furthermore, a negative dobutamine stress test was characterized by a high negative predictive value (0.96 for echocardiography; 0.97 for tomoscintigraphy). The study further demonstrated that the cardiac response (ischaemic versus non-ischaemic) to dobutamine stress was concordantly classified by echocardiographic and tomoscintigraphic techniques in 96% of cases. It is concluded that complementary non-invasive cardiac stress testing by dobutamine is indicated only in patients with clinically apparent coronary artery disease. [less ▲]

Detailed reference viewed: 22 (2 ULg)
Peer Reviewed
See detailPeyer's Patches in Murine Aids: Dissociation between Lymphoproliferation and Anergy
Colombi, S.; Moutschen, Michel ULg; de Leval, Laurence ULg et al

in Scandinavian Journal of Immunology (1997), 45(2), 175-81

RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches ... [more ▼]

RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches (PP). To understand the cellular interactions underlying lymphoproliferation further, the authors investigated the fate of PP in RadLV-Rs infected mice. The atrophy of PP was mostly due to the depletion of B cells, while the proportion of CD4+ and CD8+ T cells was increased. Nevertheless, B cell phenotype was modified with the emergence of lymphocytes with a low expression of B220 in infected PP. T cells characterized by a memory/activated phenotype in control PP did not undergo phenotypical changes after viral infection (i.e. regarding Thy-1 and CD44 expression). Despite the absence of lymphoproliferation, PP T and B cells displayed altered responses to mitogens in vitro. Finally, alterations of the expression of adhesion molecules and vascular addressins could not explain the atrophy of PP by a reduced homing to this lymphoid site. B cells and T cells from normal PP are clearly different from lymph nodes (LN) lymphocytes. The authors propose that the particular functional state which characterizes PP lymphocytes influences the B cell/T cell crosstalk necessary for RadLV-Rs-induced lymphoproliferation. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailEffet des protéines et des fibres alimentaires sur les pertes iléales d'acides aminés endogènes chez le porc.
Leterme, Pascal; Rossi, Florence; Thewis, André ULg

in Journées de la Recherche Porcine en France (1997), 29

An N-free diet was supplemented with limited but increasing amounts of proteins (30, 60, 90 g/kg diet from a mixture of casein and egg yolk), in order to measure their effect on the ileal endogenous amino ... [more ▼]

An N-free diet was supplemented with limited but increasing amounts of proteins (30, 60, 90 g/kg diet from a mixture of casein and egg yolk), in order to measure their effect on the ileal endogenous amino acid (AA) losses in pigs. The study was conducted at 2 dietary fibre levels: 20 and 80 g/kg, isolated from pea seeds. Compared to the N-free diet, a supply of 30 g proteins was sufficient to obtain a positive N retention and the following supplies allowed a constant and linear increase (0.88 g N retained/g N intake). The same supply induced an increase in ileal endogenous losses, compared to the control (10.7 vs 7.2 g AA/kg DMi for the low fibre diet) but the difference was not significant because of a high variability between the pigs. The supplies of 60 and 90 g proteins did not modify the level of the losses either: 10.2 and 10.6 g AA/kg DMi, respectively. The same trends were observed for the diets with a high fibre level but, in this case, the losses were significantly higher: respectively 14.9, 16.7, 15.7 and 17 g AA/kg DMi. On the other hand, the fraction of the digesta containing the free AA and the small peptides (< 3 kDa), supposed to be mainly of dietary origin, remained independent of the protein level. This suggests a virtually complete digestibility of the dietary proteins. Thus, pea fibres induce a significant increase of the ileal endogenous losses but without disturbing the protein digestion process, as suggested by the N retention. The protein supply probably increased the digestive secretions but the latter could have been highly reabsorbed, due to a lack in dietary factors susceptible to increase the reabsorption. [less ▲]

Detailed reference viewed: 88 (3 ULg)
Full Text
See detailComment je traite ... un melasma du visage
Pierard, Gérald ULg

in Revue Médicale de Liège (1997), 52(2), 58-9

Detailed reference viewed: 6 (0 ULg)
Peer Reviewed
See detailVers une chirurgie "supraconservatrice" des lésions mammaires infracliniques?
Lifrange, Eric ULg; Colin, Claude ULg

in Revue Médicale de Liège (1997), 52(2), 72-6

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailThoracic sequelae after surgical closure of the patent ductus arteriosus in premature infants
SEGHAYE, Marie-Christine ULg; Grabitz, R.; Alzen, G. et al

in Acta Paediatrica (1997), 86(2), 213-6

Thirty-six children (median chronological age 6 years 1 month) who had undergone surgical closure of a patent ductus arteriosus through a left posterolateral thoracotomy in the neonatal period (median ... [more ▼]

Thirty-six children (median chronological age 6 years 1 month) who had undergone surgical closure of a patent ductus arteriosus through a left posterolateral thoracotomy in the neonatal period (median gestational age 32 weeks) were investigated prospectively with respect to anatomical and functional changes of the chest. At follow-up examination, residual or recurrent patent ductus arteriosus was not observed. Three patients had chronic bronchial obstruction. Two patients showed pathological musculoskeletal thoracic sequelae that did not require any treatment at the time of follow-up; persistence of immediate postoperative left phrenic palsy (n = 1) and thoracic scoliosis (n = 1). Twenty of the 27 patients in whom chest X-ray was performed had minor radiological skeletal anomalies in the form of rib deformation or fusion related to the thoracotomy, lesions which have a potential to induce thoracic scoliosis. Left shoulder elevation at chest X-ray and isolated left arm dysfunction at clinical examination were not observed. Despite the low incidence of scoliosis and the absence of left arm dysfunction observed at mid-term follow-up in our series, the incidence of minor rib deformations with a potential to induce severe anomalies such as scoliosis should motivate late follow-up examination at adolescence to definitively assess the prevalence of thoracic sequelae after surgical closure of the patent ductus arteriosus in premature infants. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailClinical Neurophysiology of Headache
Schoenen, Jean ULg

in Neurologic Clinics (1997), 15(1), 85-105

Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches ... [more ▼]

Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches. They are traumatic, able to explore simple or more complex neural activities, and to some extent capable of reflecting activity in certain neurotransmitter systems as well as the action of pharmacologic agents on the CNS. This article reviews the interest and limits of electroencephalography, evoked potentials, electromyography, and nocifensive reflexes in primary headaches. Because neurophysiologic methods are no more than indirect means of looking into the "black box," their results need to be interpreted with caution and, whenever possible, should be compared in the same study with clinical behavioral and biochemical data. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
See detailPharma Clinics. Le médicament du mois. Le benzamycin, une actualisation du traitement topique de l'acné
Pierard, Gérald ULg

in Revue Médicale de Liège (1997), 52(2), 120-2

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailEls problemes de la violència esportiva. 10 anys després de Heysel
Comeron, Manuel ULg; Van Limbergen, Kris

in Revista d’Historia L'Avenç (1997), (211), 25-32

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es ... [more ▼]

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es relaciona llavors amb comportaments d'agressio fisica i de vandalisme produïts pels espectadors d'una manifestacio esportiva, mes concretament dels partits de futbol. [less ▲]

Detailed reference viewed: 50 (1 ULg)
Peer Reviewed
See detailInterventional atrioseptostomy by application of monopolar high-frequency alternating current : In vitro evaluation of a new device.
Grabitz, R. G.; Handt, S.; Vanopbroeke, H. J. et al

in Investigative Radiology (1997), 32(2), 90-3

RATIONALE AND OBJECTIVES: The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with ... [more ▼]

RATIONALE AND OBJECTIVES: The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with porcine atria. METHODS: The device consists of a symmetrical cage of six superelastic monofile wires, including a microthermistor that is placed via a catheter into a punctured hole in the porcine foramen ovale. The device is used as a differential electrode for monopolar, temperature-controlled application of high-frequency alternating current for thermal modelling of ASD. RESULTS: Application of current for 60 seconds caused temperature-dependent, sized ASDs. CONCLUSION: In vivo animal studies to evaluate possible side effects and long term patency of the ASDs are justified and warranted. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailExpression of somatostatin receptor SST4 in human placenta and absence of octreotide effect on human placental growth hormone concentration during pregnancy.
Caron, Philippe; Buscail, Louis; Beckers, Albert ULg et al

in Journal of Clinical Endocrinology and Metabolism (1997), 82(11), 3771-3776

In pregnancy, the human placenta GH acts as a growth-promoting hormone and appears to be the main stimulator of insulin-like growth factor I (IGF-I) secretion. In a woman with a TSH-secreting macroadenoma ... [more ▼]

In pregnancy, the human placenta GH acts as a growth-promoting hormone and appears to be the main stimulator of insulin-like growth factor I (IGF-I) secretion. In a woman with a TSH-secreting macroadenoma, successful treatment with the somatostatin analog octreotide was conducted during the first month and the second half of pregnancy without side-effects on placental and fetal development. As observed in normal pregnancy, both serum placental GH and IGF-I levels increased throughout pregnancy and dropped sharply after delivery. In placental membranes from both treated and healthy untreated patients, we demonstrated the presence of high affinity binding sites for somatostatin-14 (Kd, 4.6 and 5.3 nmol/L; binding capacity, 1.53 and 1.35 pmol/mg protein, respectively). These receptors displayed low affinity for octreotide (IC50, 1.2-2 mumol/L), suggesting the presence of SST1 and/or SST4 receptors. We found that messenger ribonucleic acids of these two subtypes were expressed in both human placental tissue and purified human cytotrophoblast cells. Finally, the SST1-selective analog, des-AA1,2,5[D-Trp8,IAmp9]S-14 had low affinity for placental somatostatin receptors. These results argue in favor of the presence of the SST4 subtype in human placenta. At the doses administered, octreotide did not bind to placental somatostatin receptors. Our results may explain the absence of changes in both human placental GH and IGF-I concentrations that we observed during octreotide treatment. [less ▲]

Detailed reference viewed: 33 (3 ULg)
Full Text
Peer Reviewed
See detailLocalization of Laminin, Fibronectin, E-Cadherin, and Integrins in Endometrium and Endometriosis
Beliard, Aude ULg; Donnez, J.; Nisolle, Michelle ULg et al

in Fertility and Sterility (1997), 67(2), 266-72

OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study ... [more ▼]

OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study. SETTING: University Hospital, Department of Gynecology and Department of Cell Biology. PATIENT(s): Eighteen endometriosis patients undergoing laparoscopy for pain or infertility and nine control patients undergoing laparoscopy for sterilization or hysterectomy. MAIN OUTCOME MEASURE(s): The expression of adhesion glycoproteins (laminin and fibronectin), their receptors alpha 1 beta 1, alpha 2 beta 1, alpha 3 beta 1, alpha 5 beta 1, and alpha 6 beta 1, and E-cadherin was determined by immunohistochemistry on frozen sections. RESULT(s): The distribution of both adhesive glycoproteins, laminin and fibronectin, and their receptors was identical in endometriosis and endometrium. Fibronectin receptors (alpha 4 beta 1, alpha 5 beta 1) displayed distinct expression patterns in endometrium and endometriosis. No endometrial glands showed positive staining for the alpha 5 chain, whereas this integrin subunit was detected in almost all endometriotic lesions. The integrin alpha 4 chain was present in all endometriotic glands but was absent from endometrial glands in the proliferative phase of the cycle. CONCLUSION(s): No difference in cell adhesion molecule localization nor receptors was observed between endometriotic and endometrial samples, except for fibronectin receptors. Their expression persisted around endometriotic glands but not in endometrium. These results suggest that fibronectin receptors could play a role in the persistence of endometriotic lesions, despite menstruation in corresponding eutopic endometrium. [less ▲]

Detailed reference viewed: 34 (5 ULg)
Full Text
Peer Reviewed
See detailAnionic polymerization of primary acrylates as promoted by Lithium 2-(2-Methoxyethoxy) ethoxide
Nugay, Nihan; Nugay, Turgut; Jérôme, Robert ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(2), 361-369

Some primary acrylates, such as methyl, ethyl, n-butyl, and n-nonyl acrylate (MA, EA, nBuA and nNonA, respectively) have been anionically polymerized by using diphenylmethyl lithium (DPMLi) as an ... [more ▼]

Some primary acrylates, such as methyl, ethyl, n-butyl, and n-nonyl acrylate (MA, EA, nBuA and nNonA, respectively) have been anionically polymerized by using diphenylmethyl lithium (DPMLi) as an initiator, in the presence of a chelating - dual ligand, i.e., a polydentate lithium alkoxide, at low temperature. It has been found that lithium 2-(2-methoxyethoxy) ethoxide (LiOEEM) is a very efficient ligand in preventing the anionic polymerization of these monomers from being disturbed by significant secondary transfer and termination reactions. Even for the difficult cases of ethyl and methylacrylate, that approach provides high polymerization yields and low polydispersity, allowing the molecular weight to be predetermined. LiOEEM/initiator molar ratio, solvent polarity, temperature and monomer concentration have proved to be key parameters in the control of the polymerization process. The efficiency of that control is however dependent on the monomer structure and improves with the length of the n-alkyl substituent, i.e., MA < EA < nBuA < nNonA. [less ▲]

Detailed reference viewed: 31 (2 ULg)
Full Text
Peer Reviewed
See detailSynthesis and characterization of biodegradable homopolymers and block copolymers based on adipic anhydride
Ropson, Nathalie; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(1), 183-192

Homopolymers of adipic anhydride (AA) and block copolymers of -caprolactone (-CL) and AA have been synthesized with aluminum triisopropoxide as an initiator. Homopolymerization was studied at 20°C in ... [more ▼]

Homopolymers of adipic anhydride (AA) and block copolymers of -caprolactone (-CL) and AA have been synthesized with aluminum triisopropoxide as an initiator. Homopolymerization was studied at 20°C in toluene and methylene chloride (CH2Cl2). The end-group analysis agrees with a coordination insertion mechanism based on the acyl-oxygen cleavage of the AA ring. Living poly(-caprolactone) (PCL) chains are very efficient macro-initiators for the polymerization of AA, with formation of diblock copolymers of a narrow molecular weight distribution. At our best knowledge, low molecular weight -aluminum alkoxide PCL macroinitiators (M¯n < 1000) allow the first valuable synthesis of PAA with a molecular weight as high as 58,000 and a quite narrow polydispersity (M¯w/M¯n = 1.2). Size-exclusion chromatography (SEC) and 13C NMR confirm the blocky structure of the copolymers, in agreement with DSC that shows two melting endotherms and two glass transitions characteristic of the crystalline and amorphous phases of PCL and PAA, respectively. Block copolymers of c-CL and AA are also sensitive to hydrolysis, which makes them possible candidates for biomedical applications. Initiation of the AA polymerization in bulk with aluminum triisopropoxide in the presence of various ligands is also discussed. [less ▲]

Detailed reference viewed: 13 (6 ULg)
Full Text
Peer Reviewed
See detailLiving Anionic Homopolymerization and Block Copolymerization of 4-Vinylpyridine at "Elevated" Temperature and Its Characterization by Size Exclusion Chromatography
Creutz, Serge; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1997), 30(1), 1-5

The anionic polymerization of 4-vinylpyridine (4VP) has been investigated in 9/1 pyridine/THF at 0 °C. After characterization of the living character of 4VP polymerization, its copolymerization with tert ... [more ▼]

The anionic polymerization of 4-vinylpyridine (4VP) has been investigated in 9/1 pyridine/THF at 0 °C. After characterization of the living character of 4VP polymerization, its copolymerization with tert-butyl methacrylate (tBMA) has been carried out also successfully. Their relative reactivity ratios have been determined. Solvent composition as well as temperature have been varied in order to evaluate their influence on the final molecular characteristics of the polymers. Finally, a new SEC methodology in 8/1/1 N,N-dimethylformamide/triethylamine/pyridine has been developed. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailLiving Anionic Homopolymerization and Block Copolymerization of (Dimethylamino)ethyl Methacrylate
Creutz, Serge; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1997), 30(1), 6-9

Anionic polymerization of (dimethylamino)ethyl methacrylate (DMAEMA) has been investigated in THF at -78°C. The presence of lithium chloride has been shown to be desirable in order to afford a narrow ... [more ▼]

Anionic polymerization of (dimethylamino)ethyl methacrylate (DMAEMA) has been investigated in THF at -78°C. The presence of lithium chloride has been shown to be desirable in order to afford a narrow molecular weight distribution as well as a good agreement between theoretical and observed molecular weight. The living character of the polymerization has been demonstrated. Thus the synthesis of block copolymers, some of them unattainable by GTP, has been carried out successfully. Finally, the anionic polymerization of mixtures of tert-butyl methacrylate (tBMA) and DMAEMA has been considered and their relative reactivity ratio estimated. The easy quaternization of (dimethylamino)ethyl methacrylate affords amphiphilic water-soluble copolymers displaying interesting characteristics as polymeric dispersants and surfactants. [less ▲]

Detailed reference viewed: 19 (2 ULg)
Peer Reviewed
See detailAn updated model of the hot nitrogen atom kinetics and thermospheric nitric oxide
Gérard, Jean-Claude ULg; Bisikalo, D. V.; Shematovich, V. I. et al

in Journal of Geophysical Research (1997), 102

New observations and reanalysis of previous measurements suggest an upward revision of the measured thermospheric nitric oxide density. Our previous model of NO production by fast N([SUP]4[/SUP]S) atom ... [more ▼]

New observations and reanalysis of previous measurements suggest an upward revision of the measured thermospheric nitric oxide density. Our previous model of NO production by fast N([SUP]4[/SUP]S) atom collisions with O[SUB]2[/SUB] has been updated. It includes the effect of soft solar X rays, Auger electrons, and a detailed treatment of N[SUB]2[/SUB] dissociative ionization channels. In addition, new calculations indicate that the transfer of translational energy in N+N[SUB]2[/SUB] collisions is less efficient than in the hard sphere approximation. This result leads to reevaluation of the energy dependent relaxation cross section and to an upward revision of the reacting efficiency of collisions of N with O[SUB]2[/SUB] to form nitric oxide. The calculated peak NO density increases by a factor of ~2 when the effect of superthermal nitrogen atoms is included. The model response of the N([SUP]4[/SUP]S) energy distribution function and NO density to solar cycle variations is presented. The NO density at 110 km changes from 5.4×10[SUP]7[/SUP] to 1.3×10[SUP]8[/SUP]cm[SUP]-3[/SUP] when the solar F[SUB]10.7[/SUB] index varies from 70 to 245, but its response depends on the magnitude of the soft X ray increase with solar activity. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Peer Reviewed
See detailFourth supplement to the catalogue of observed periods of Ap stars
Catalano, F. A.; Renson, Pierre ULg

in Astronomy and Astrophysics. Supplement Series (1997), 121

New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before ... [more ▼]

New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before but it was not reported in previous issues of this catalogue. For many stars also present in previous issues of the catalogue new determinations of the periods are given. Recently attributed variable star names are also quoted. Table 1, notes to this Table and related references are only available in LaTEX form at the CDS via anonymous ftp 130.79.128.5 (filename: DS1178.tex). [less ▲]

Detailed reference viewed: 7 (1 ULg)
Peer Reviewed
See detailDifferent universality classes for SOC in models driven by extremal dynamics
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Europhysics Letters [=EPL] (1997), 37(1), 1-6

We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree ... [more ▼]

We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree-like model does not seem to belong to any already studied SOC universality class. This is shown through a discussion of the dynamics and the so-called gap equation which does not hold here. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailIncrease in Cytokine Production (Il-1 Beta, Il-6, Tnf-Alpha but Not Ifn-Gamma, Gm-Csf or Lif) by Stimulated Whole Blood Cells in Postmenopausal Osteoporosis
Zheng, S. X.; Vrindts-Gevaert, Yvonne; Lopez, Marie-Josée ULg et al

in Maturitas (1997), 26(1), 63-71

Postmenopausal osteoporosis is a progressive disorder characterized by a decreased bone mass and increased susceptibility to fractures. Several investigations have suggested that one of the mechanisms ... [more ▼]

Postmenopausal osteoporosis is a progressive disorder characterized by a decreased bone mass and increased susceptibility to fractures. Several investigations have suggested that one of the mechanisms through which estrogen prevents bone loss was a modulation on secretion or release of various cytokines that are known to influence bone remodeling, even if some recent data have challenged this hypothesis. However, in established osteoporosis, the possibility that enhanced cytokines activity may account for the progression of this disease remains unclear and controversial. We sought here to determine whether production of IL-1 beta, IL-6, TNF-alpha, IFN-gamma, GM-CSF and LIF, after direct stimulation in whole blood, was different in healthy (n = 30) or osteoporotic postmenopausal women (n = 24) and whether lumbar bone density (1-BMD) correlated with the values of cytokine production observed in these conditions. A significant difference was observed between the osteoporotic and control subjects for IL-1 beta (p < 0.0001), IL-6 (p < 0.001) and TNF-alpha (p = 0.027) productions, the values being higher in the osteoporotic women. No significant differences between the groups were observed for IFN-gamma (p = 0.51), GM-CSF (p = 0.70) or LIF (p = 0.97). In the whole population, statistically significant negative correlations were observed between lumbar BMD and IL-1 beta (r = -0.46) (p < 0.0005), IL-6 (r = -0.50) (p < 0.0001) and TNF-alpha (r = -0.39) (p < 0.005) production while no such correlations were observed for IFN-gamma, GM-CSF or LIF. In conclusion, the study of cytokine production by immune cells cultured in autologous whole blood suggests that in women more than 10 years past the menopause and presenting a decrease in lumbar bone density corresponding to the new WHO definition of "osteoporosis', production of IL-1 beta, IL-6 and TNF-alpha is still increased compared to controls matched for age and ovarian function, while no differences are reported for IFN-gamma, GM-CSF or LIF production. [less ▲]

Detailed reference viewed: 58 (6 ULg)
Full Text
Peer Reviewed
See detailElevated Plasma Alpha 1-Acid Glycoprotein Levels: Lack of Connection to Resistance to Vecuronium Blockade Induced by Anticonvulsant Therapy
Hans, Pol ULg; Brichant, Jean-François ULg; Pieron, F. et al

in Journal of Neurosurgical Anesthesiology (1997), 9(1), 3-7

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled ... [more ▼]

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled for routine neurosurgery were included in the study. The patients were treated (TG; n = 20) with phenytoin (n = 15) and/or carbamazepine (n = 4) and/or phenobarbital (n = 3) for > or = 6 days or were left untreated (UG; n = 11, control group). TG patients were further assigned to one of two subgroups according to the plasma anticonvulsant level measured the day before surgery and found to be within (TGW, n = 10) or below (TGB, n = 10) the therapeutic range. Finally, the 31 patients were divided into two more groups according to their plasma AAG levels: higher than (HAAG, n = 17) or within (NAAG, n = 14) the normal range (25-94 mg dl-1). Anesthesia was induced and maintained with propofol and sufentanil. Muscle relaxation was obtained with vecuronium 0.1 mg kg-1. A train-of-four (TOF) stimulation mode at 2 Hz was applied to the ulnar nerve every 15 s, and neuromuscular transmission was assessed using a TOF-Guard accelograph monitor. Plasma AAG concentrations (means +/- SEM) were 103.7 +/- 7.6 mg dl-1 in TG, 80.7 +/- 6.7 mg dl-1 in UG, 95.9 +/- 13.2 mg dl-1 in TGW, 111.6 +/- 7.6 mg dl-1 in TGB. 114.9 +/- 7.4 mg dl-1 in HAAG, and 71.4 +/- 3.8 mg dl-1 in NAAG groups. The differences in plasma AAG concentrations between UG and TG and between HAAG and NAAG groups were statistically significant. No significant relationship was found between plasma AAG levels and phenytoin concentrations (r = -0.26). The time (mean +/- SEM) to recovery of T1 to 25% of control was significantly shorter in TG (28.2 +/- 1.4 min) than in UG (42.2 +/- 3.1 min) but did not differ significantly according to the plasma anticonvulsant level (27.3 +/- 2.0 min in TGW; 29.1 +/- 1.9 min in TGB) and the plasma AAG level 31.7 +/- 1.9 min in HAAG; 35.3 +/- 3.3 min in NAAG). The time for the TOF ratio to recover to 25% yielded similar profiles and statistical significance levels: TG, 32.9 +/- 2.2 min; UG, 51.2 +/- 4.0 min; TGW, 35.0 +/- 3.9 min; TGB, 30.7 +/- 1.8 min; HAAG, 38.1 +/- 3.1 min; NAAG, 42.0 +/- 4.1 min. We conclude that anticonvulsant therapy induces an increase in plasma AAG independently of the plasma anticonvulsant level. However, duration and recovery of vecuronium blockade do not differ according to plasma AAG levels. Consequently, elevated AAG does not contribute to the resistance to vecuronium blockade induced by anticonvulsants. [less ▲]

Detailed reference viewed: 40 (5 ULg)
Peer Reviewed
See detailGeometric and healing laws in simple stochastic models of fracture in a sputtering process
Dhulst, R.; Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 55(1), 189-193

We investigated two simple models of two-dimensional square lattice fracture under sputtering process conditions extending a previously studied model by Ausloos and Kowalski [Phys. Rev. B 45, 12 830 (1992 ... [more ▼]

We investigated two simple models of two-dimensional square lattice fracture under sputtering process conditions extending a previously studied model by Ausloos and Kowalski [Phys. Rev. B 45, 12 830 (1992)]. The models differ by the particle displacement rules during the fracture. Healing of the medium is observed in both models. This effect implies the formation of several thresholds during sputtering process fracture. They are distributed as a size-dependent power law. An avalanche like exponent is also obtained. We study this phenomenology within scaling arguments of classical percolation theory and mean-field arguments. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailLiving free radical polymerization of macromonomers: preparation of well defined graft copolymers
Hawker, Craig Jon; Mecerreyes, David; Elce, Edmund et al

in Macromolecular Chemistry and Physics (1997), 198(1), 155-166

Well defined graft copolymers have been synthesized by a nitroxide-mediated "living" free radical process using pre-formed macromonomers. Analysis of the graft systems revealed that the macromonomer was ... [more ▼]

Well defined graft copolymers have been synthesized by a nitroxide-mediated "living" free radical process using pre-formed macromonomers. Analysis of the graft systems revealed that the macromonomer was efficiently incorporated into the polymeric back-bone to give block copolymers of controlled molecular weight and narrow polydispersi-ties. An added benefit of the "living" free radical process is that macromonomers, such as polylactide or polycaprolactone, which contain reactive functional groups can be used to form novel graft Systems using this approach. Functionalized monomers or polymeric initiators were also used in the copolymerization mixture to give graft Systems with a variety of functional groups attached to the backbone. [less ▲]

Detailed reference viewed: 66 (10 ULg)
Full Text
Peer Reviewed
See detailExpression of Bone Matrix Proteins in Human Breast Cancer: Potential Roles in Microcalcification Formation and in the Genesis of Bone Metastases
Bellahcene, Akeila ULg; Castronovo, Vincenzo ULg

in Bulletin du Cancer (1997), 84(1), 17-24

The skeleton is the privileged target of metastatic human breast cancer cells. Bone metastases are indeed found in virtually all advanced breast cancer patients and generate major morbidity. The high ... [more ▼]

The skeleton is the privileged target of metastatic human breast cancer cells. Bone metastases are indeed found in virtually all advanced breast cancer patients and generate major morbidity. The high osteotropism of breast cancer cells suggests that they exhibit a selective affinity for mineralized tissues. The observation that mammary malignant cells are able to induce hydroxyapatite crystals deposition within the primary tumour suggests that they can generate a microenvironment that favors the crystallization of calcium and phosphate ions into the bone specific hydroxyapatite. Osteonectin (OSN), osteopontin (OPN) and bone sialoprotein (BSP), 3 bone matrix proteins involved in bone matrix mineralization, are expressed in human breast cancers. BSP, an RGD (Arg-Gly-Asp) containing phosphoprotein, initiates hydroxyapatite deposition and mediates attachment of osteoclast to the same crystals prior to their resorption. Detection of BSP at both the protein and the mRNA levels in human breast cancer and in human breast cancer cell lines (MCF-7, T47-D and MDA-MB 231) indicates that mammary malignant cells synthesize directly BSP rather than uptaking it from the serum. Interestingly, the level of BSP expression correlates with the development of bone metastases and with poor survival. These data suggest that the ectopic expression of bone matrix proteins could be involved in conferring osteotropic properties to circulating metastatic breast cancer cells. These observations open new alleys of investigation for the identification of the molecular mechanisms responsible for the genesis of bone metastases. [less ▲]

Detailed reference viewed: 71 (2 ULg)
Full Text
Peer Reviewed
See detailTriblock copolymer based thermoreversible gels. 1. Self-association of sPMMA end-blocks in o-xylene and viscoelasticity of the gels
Yu, Jian Ming; Jérôme, Robert ULg; Teyssié, Philippe

in Polymer (1997), 38(2), 347-354

Syndiotactic poly(methyl methacrylate) (sPMMA)-polybutadiene (PBD)-sPMMA triblock copolymers, or MBM, have been studied in the presence of o-xylene which is a selective solvent for the central PBD block ... [more ▼]

Syndiotactic poly(methyl methacrylate) (sPMMA)-polybutadiene (PBD)-sPMMA triblock copolymers, or MBM, have been studied in the presence of o-xylene which is a selective solvent for the central PBD block. Syndiotactic PMMA is known to self associate in o-xylene. The central PBD sequence does not prevent the self-association of sPMMA from occurring. Actually, this phenomenon contributes to the stability of the gels formed at room temperature. An endotherm is observed at 35°C, which is responsible for a gel-sol transition. The original solutions have been heated up to 80°C and then rapidly cooled down below 35°C and maintained at 10, 20 and 25°C respectively. The self-association of the sPMMA outer blocks, and thus the liquid-solid transition, have been studied at each of these temperatures. Dependence of the gel viscosity on frequency and temperature effects on viscoelasticity has also been investigated. [less ▲]

Detailed reference viewed: 40 (2 ULg)
Full Text
Peer Reviewed
See detailStereotaxic Needle-Core Biopsy and Fine-Needle Aspiration Biopsy in the Diagnosis of Nonpalpable Breast Lesions: Controversies and Future Prospects
Lifrange, Eric ULg; Kridelka, Frédéric ULg; Colin, Claude ULg

in European Journal of Radiology (1997), 24(1), 39-47

OBJECTIVE: To determine the advantages and limitations of a combined stereotaxic fine-needle aspiration biopsy and needle-core biopsy in the diagnosis of 353 nonpalpable breast lesions with special ... [more ▼]

OBJECTIVE: To determine the advantages and limitations of a combined stereotaxic fine-needle aspiration biopsy and needle-core biopsy in the diagnosis of 353 nonpalpable breast lesions with special attention given to the collection of follow-up data. METHODS AND MATERIAL: 353 nonpalpable breast lesions underwent 'one pass' stereotaxic fine-needle aspiration (21 gauge needle) and needle-core biopsy (18 gauge needle) at our institution from January 1990 to October 1993. Stereotaxic biopsies were carried out by means of an 'add-on unit'. Surgical biopsy was usually recommended for highly suspicious radiologic patterns and/or needle biopsy reports classified as atypical or malignant. In all other cases mammographic follow-up was advised at 6 months and then annually for 3 years. The data were collected retrospectively during September 1995 (theoretical average follow-up of greater than 3 years). RESULTS: Following the combined needle biopsy technique procedure, surgery was recommended for 83 lesions. Fifty-four cancers were associated to these suspicious lesions. Because of changing radiological or clinical pattern during follow-up (mean follow-up: 22 months), 11 cancers were detected among the 270 lesions initially considered not to need surgery. Forty-three percent of the 65 malignant lesions were initially read as having less than highly suspicious mammographic features. There was no significant difference between the sensitivity and the specificity of one pass fine-needle aspiration biopsy (57% and 96% respectively) and needle-core biopsy (60% and 97% respectively), but noncontributive samples were not included in the false negative diagnoses and atypical samples were included in the true positive diagnoses. Of the 11 missed cancers, nine were manifested initially by clusters of calcifications. Our diagnostic approach was significantly less sensitive (P = 0.006) and less specific (P = 0.032) in cases of clusters of calcifications (31% false negative diagnoses) than in cases of soft-tissue masses (5.5% false negative diagnoses). In this study, an average delay in diagnoses of 22 months was responsible for a significantly increased percentage of axillary node positive invasive cancer (P < 0.001) and six of the 11 missed cancers were palpable at the time of the delayed diagnosis. For the nine cancers initially manifested by calcifications, the 22 months delay in diagnosis was responsible for a nonsignificant increase of microinvasive type at the expense of carcinoma in situ. CONCLUSION: Our enthusiasm with the sensitivity of this double stereotaxic needle sampling has been tempered by the results of this reanalysis in the light of a mean theoretical follow-up of three years. Our diagnostic approach was adequate in the presence of soft-tissue masses but not valid in the presence of clustered calcifications. When dealing with calcifications, multiple samplings must be done in order to improve the sensitivity of the diagnosis. Furthermore, this study does not favour the theory that the majority of mammographically detected cancers are indolent and highlights the poor sensitivity of the mammographic follow-up of nonpalpable lesions. [less ▲]

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailMiscellaneous and Experimental Agents
Reginster, Jean-Yves ULg

in American Journal of the Medical Sciences (The) (1997), 313(1), 33-40

Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally ... [more ▼]

Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally demonstrated full prevention of the appearance or the recurrence of axial or peripheral fractures so far, many investigational compounds are being developed. Anabolic steroids act mainly as inhibitors of bone resorption with very few, if any, effects on bone formation. Because of the high occurrence of signs of virilization and the weak effects on bone structure, the risk/benefit ratio in osteoporosis should be considered at least problematic. If ongoing large-scale trials confirm the expected benefits of estrogen antagonist/agonists on the skeleton and confirm no cardiovascular risk to postmenopausal women with optimal uterine safety, these substances are likely to become the most prominent alternative to hormonal replacement therapy after the menopause. Additional studies are requested to evaluate the potential benefit of growth hormone or insulin-like growth factors in treatment of osteoporosis. Ipriflavone acts predominantly as an inhibitor of bone resorption. To confirm the efficacy of ipriflavone on the prevention of vertebral fractures and its effects on bone mineral density in women with postmenopausal established osteoporosis, a large multicentric European study is being conducted. Treatment with parathyroid peptides induces a significant gain in bone mass, mainly in the axial skeleton. Long-term studies that compare peptides, doses, and regimes are needed to better understand the exact position of parathyroid peptides as treatment of osteoporosis. Prolonged administration of strontium to postmenopausal osteoporotic women resulted in a decoupling between bone resorption and formation that yielded a significant increase in the lumbar spine bone mineral density of treated subjects. In the view of these promising results and of the excellent tolerance of strontium during preliminary trials, additional investigations of this compound in prevention and treatment of osteoporosis should be promptly initiated. Several other compounds have been punctually suggested for treatment of osteoporosis or are at very early stages of development. Finally, besides pharmacologic approaches to the treatment of osteoporosis, hip fractures may also be reduced by the use of hip protectors. [less ▲]

Detailed reference viewed: 5 (2 ULg)
Peer Reviewed
See detailConstruction and properties of fractal trees with tunable dimension: The interplay of geometry and physics
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review E (1997), 55(1), 94-98

In this paper, we emphasize three different techniques for the growth of fractal trees with a desired fractal dimension D-f. The three different growths are due to the influence of (i) stretched branches ... [more ▼]

In this paper, we emphasize three different techniques for the growth of fractal trees with a desired fractal dimension D-f. The three different growths are due to the influence of (i) stretched branches, (ii) dead ends, or (iii) a variable branching rate. Several examples are given. We point out that geometrical and physical properties (skeleton dimension, percolation exponents, self-avoiding walk) of fractal tress depend strongly on their type. The most striking result is that the critical exponents at the percolation transition are nonuniversal since they depend on the tree type. The critical exponents depend on D-f for trees of types (ii) and (iii). [less ▲]

Detailed reference viewed: 39 (0 ULg)
Peer Reviewed
See detailCytotoxic interactions of 5-fluorouracil and nucleoside analogues in vitro
Li, Y-X; COUCKE, Philippe ULg; Paschoud, N et al

in Anticancer Research (1997), 17(1A), 21-27

The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3 ... [more ▼]

The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3'-deoxy-2', 3'-didehydrothymidine (D4T), 5-iododeoxyuridine (IdUrd) and 2',3'-dideoxycytidine (DDC) were tested at different concentrations (5-600 microM) as modulators of 5-FU. The experimental endpoints were cellular viability and cell cycle distribution. The combination of 5-FU and AZT or D4T yielded supra-additive cytotoxic effects in both cell lines at all concentrations. On WiDr, IdUrd at high concentrations of 50 and 100 microM showed a supra-additive effect whereas at low concentrations (5, 10 and 20 microM) the effect was antagonistic. 5-FU combined with IdUrd produced a synergistic effect on MCF-7 cells at all concentrations. DDC antagonised the toxic effect of 5-FU on the WiDr cell line. In WiDr cells, a significant increase in the overall S-phase was observed 48 and 72 hours after exposure to D4T, AZT and DDC at the low concentration of 10 microM. On the contrary, this accumulation in S-phase was not present in MCF-7 cells. The combined effect of 5-FU and nucleoside analogues in vitro is dependent on the type and concentration of nucleosides and the cell-line tested. AZT, D4T and IdUrd are more likely to be subjected to more intensive in vitro and in vivo research as far as modulation of 5-FU toxicity is concerned. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailAnalysis of Equine Scintigraphical Lung Images
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, H. et al

in Veterinary Journal (1997), 153(1), 49-61

A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to ... [more ▼]

A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to establish reference ranges of I/Q distribution pattern. Computed I/Q images were divided in three regions based on the activity due to the inhalation (I) versus perfusion (Q) procedure. For each region a regional mismatching factor (Iri), i.e. the I/Q of the region, and an intraregional mismatching factor (Lri), which expresses the variability of pixels' I/Q within the region, were calculated. The Per(Ri) and Cen(Ri), which are the percentage of pixels in the parenchymal and in the central parts of the lung belonging to the region, were also computed. Results of this analysis showed a good match between I and Q distribution pattern. [less ▲]

Detailed reference viewed: 30 (9 ULg)
Full Text
Peer Reviewed
See detailStreptococcus difficile Is a Nonhemolytic Group B, Type Ib Streptococcus
Vandamme, Peter; Devriese, L. A.; Pot, B. et al

in International Journal of Systematic Bacteriology (1997), 47(1), 81-5

Whole-cell protein electrophoretic analysis of the type strain of Streptococcus difficile (LMG 15799) revealed that this organism was indistinguishable from Streptococcus agalactiae strains. Although LMG ... [more ▼]

Whole-cell protein electrophoretic analysis of the type strain of Streptococcus difficile (LMG 15799) revealed that this organism was indistinguishable from Streptococcus agalactiae strains. Although LMG 15799'r (T = type strain) was originally described as serologically untypeable, we found that this strain was a group B streptococcus belonging to the capsular polysaccharide antigen type Ib group. The biochemical reactivity of S.difficile, which differed from the biochemical reactivity of typical S. agalactiae strains mainly by being less versatile, is similar to the biochemical reactivity of other group B, type Ib streptococci isolated from poikilothermic animals, such as fish and frogs. [less ▲]

Detailed reference viewed: 16 (1 ULg)
See detailLes Banyarwanda du Sud-Kivu: les Banyamulenge?
Kabamba, Bob ULg

in Revue Nouvelle (1997), (n°1), 7-15

Detailed reference viewed: 90 (7 ULg)
Peer Reviewed
See detailAccident vasculaire cérébral et thrombus aortique chez un patient déficient en protéine S
Lambermont, Bernard ULg; Ghuysen, Alexandre ULg; Marcelle, Roland ULg et al

in Archives des Maladies du Coeur et des Vaisseaux (1997), 90(1), 99-102

The authors report the case of a 50 year old man admitted to hospital with a right hemiplegia and aphasia of sudden onset in whom embolic fragments were found in the left mid and anterior cerebral artery ... [more ▼]

The authors report the case of a 50 year old man admitted to hospital with a right hemiplegia and aphasia of sudden onset in whom embolic fragments were found in the left mid and anterior cerebral artery territories at left carotid angiography : transoesophageal echocardiography demonstrated a protrusive plaque of atherosclerosis in the ascending aorta and a pediculated thrombosis in the descending aorta. Biological investigations revealed a protein S level of 3% (normal : 70-140%). This case illustrates the acute development of a thromboembolic phenomenon originating from the aortic arch in a patient with a coagulation defect. [less ▲]

Detailed reference viewed: 50 (9 ULg)
Full Text
Peer Reviewed
See detailCalcitonine et vieillissement osseux
Reginster, Jean-Yves ULg

in Pathologie Biologie (1997), 45(1), 52-6

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that ... [more ▼]

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that dose may also be sufficient to prevent trabecular bone loss and that higher doses (> or = 200 IU/day) induce a significant increase in spinal bone mineral content. Calcium supplements should be systemically administered when calcitonin is given, particularly at high doses. Rectal calcitonin seems also to be an efficient alternative in prevention of trabecular bone loss. Further studies are required to evaluate the effect of calcitonin in prevention of cortical bone loss. In established osteoporosis, calcitonin may prevent further bone loss at trabecular and cortical sites. A similar benefit is obtained following parenteral or nasal administration of the drug. Long-term administration of nasal salmon calcitonin induces a significant dose-dependent gain of bone at the lumbar spine, whereas discontinuous therapy with a ratio of 1:2 or 2:3 between the treatment and nontreatment periods is the best regimen for cortical bone. Epidemiological, retrospective, and prospective studies provide a convergent network of evidence that calcitonin administration in osteoporosis contributes to reduce significantly the frequency of subsequent fractures, both in the spine and in the hip. Finally, in established osteoporosis, nasal calcitonin possesses a potent analgesic effect, reduces the duration of bed confinement, and decreases the number of concomitant analgesic medications. The well-demonstrated effects of nasal calcitonin permit it to be considered as a highly rational solution for the prevention and the treatment of postmenopausal osteoporosis. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailTowards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.
Dunner, S.; Charlier, Carole ULg; Farnir, Frédéric ULg et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1997), 8(6), 430-5

The Spanish "Asturiana" cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or "culones". We demonstrate by linkage analysis ... [more ▼]

The Spanish "Asturiana" cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or "culones". We demonstrate by linkage analysis that this muscular hypertrophy involves the mh locus previously shown to cause double-muscling in the Belgian Blue cattle breed, pointing towards locus homogeneity of this trait across both breeds. Moreover, using a twopoint and multipoint maximum likelihood approach, we show that flanking microsatellite markers are in linkage disequilibrium with the mh locus in both breeds albeit with different alleles. Finally, we discuss how allelic homogeneity across breeds might be exploited to achieve efficient genetic fine-mapping of the mh locus. [less ▲]

Detailed reference viewed: 25 (4 ULg)
Full Text
Peer Reviewed
See detailPirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties.
Bruhwyler, J.; Liégeois, Jean-François ULg; Geczy, J.

in Pharmacological Research (1997), 36(1), 23-33

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical ... [more ▼]

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical irreversible monoamine oxidase inhibitors. Its main mechanism of action consists of a selective and reversible inhibition of monoamine oxidase A. Secondarily, it exerts an inhibitory effect on noradrenaline and 5-hydroxytryptamine reuptakes. It has no effect on the dopaminergic and cholinergic systems. It has only a low potential for amplifying tyramine and noradrenaline pressor effect, which makes one expect that it will not be at the basis of a 'cheese effect'. Pirlindole has an absolute bioavailability of between 20 and 30% due to an extensive first-pass effect. Orally, the Tmax varies between 2.5 and 6 h in the rat and 0.8 and 2 h in the dog. Two phases of elimination (7.5 and 34-70 h) are measured in the rat and three phases in the dog (1.3, 10.8 and 185 h); it is extensively metabolized. The rat eliminates mainly unconjugated products while the dog eliminates mostly conjugated products. Acute and chronic toxicological studies have not revealed potentially dangerous effects of the drug at the usual doses. It does not present measurable mutagenic, clastogenic or carcinogenic properties. Thus, pirlindole shows pharmacological, pharmacokinetic and toxicological properties which make it suitable for the management of depression. [less ▲]

Detailed reference viewed: 43 (1 ULg)
See detailLa cartographie des hydrophytes appliquée à l'étude des écosystèmes fluviaux: un outil d'analyse pour la restauration des anciens chenaux rhénans
Klein, J. P.; Vanderpoorten, Alain ULg; Sanchez-Perez, J. et al

in Lejeunia, Revue de Botanique (1997), 153

Detailed reference viewed: 17 (5 ULg)