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See detailSequence-Analysis Of A 40-Kb Dna Fragment From Chromosome-X Of Saccharomyces-Cerevisiae
Vandenbol, Micheline ULg; Bolle, Pa.; Dion, C. et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailCytochemical and immunocytochemical study of coiled bodies in different cultured cell lines.
Thiry, Marc ULg

in Chromosoma (1994), 103(4), 268-76

We analyzed by different cytochemical and immunocytochemical approaches the biochemical compositon of coiled bodies in three different cultured cell lines. Coiled bodies are stained by the AgNOR staining ... [more ▼]

We analyzed by different cytochemical and immunocytochemical approaches the biochemical compositon of coiled bodies in three different cultured cell lines. Coiled bodies are stained by the AgNOR staining method and by the EDTA regressive staining method preferential for ribonucleoprotein (RNP). Using the in situ polyadenylate nucleotidyl transferase-immunogold technique or anti-RNA antibodies, we decisively demonstrated the presence of appreciable amounts of RNA in coiled bodies. Neither the in situ terminal deoxynucleotidyl transferase-immunogold technique nor anti-DNA antibodies revealed any DNA in coiled bodies. Coiled bodies thus appear as distinct regions of cell nuclei involved in some steps of RNA metabolism but not directly in RNA synthesis. Their relationships with the dense fibrillar component of the nucleolus and with interchromatin granule clusters are discussed. [less ▲]

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See detailPretreatment minimal staging for non-small cell lung cancer: an updated consensus report
Goldstraw; Rocmansb; Ball et al

in Lung Cancer (1994), 11(supp 3), 1-4

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See detailTechnical Efficiency and Productivity Growth in an Era of Deregulation: the Case of Airlines
Distexhe, Véronique; Perelman, Sergio ULg

in Schweizerische Zeitschrift für Volkswirtschaft und Statistik = Revue Suisse d'Economie Politique et de Statistique (1994), (130), 669-689

In this paper we measure technical efficiency and productivity gains in airline activities. Non-parametric frontiers and Malmquist indices of productivity are estimated for thirty-three airlines observed ... [more ▼]

In this paper we measure technical efficiency and productivity gains in airline activities. Non-parametric frontiers and Malmquist indices of productivity are estimated for thirty-three airlines observed over the period 1977-1988. We identify three sources of growth: technological progress, efficiency change and route network characteristics. The results bring to light the reasons that pushed several airlines to merge when markets were deregulated. [less ▲]

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See detailLa gestion des données avec le logiciel V. M. S.
Claustriaux, Jean-Jacques ULg; Deltenre, Alain

in Notes de Statistique et d'Informatique (1994), 2

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See detailReasoning about Infinite Computations
Vardi, Moshe Y.; Wolper, Pierre ULg

in Information & Computation (1994), 115(1), 1-37

We investigate extensions of temporal logic by connectives defined by finite automata on infinite words. We consider three different logics, corresponding to three different types of acceptance conditions ... [more ▼]

We investigate extensions of temporal logic by connectives defined by finite automata on infinite words. We consider three different logics, corresponding to three different types of acceptance conditions (finite, looping, and repeating) for the automata. It turns out, however that these logics all have the same expressive power and that their decision problems are all PSPACE-complete. We also investigate connectives defined by alternating automata and show that they do not increase the expressive power of the logic or the complexity of the decision problem. (C) 1994 Academic Press, Inc. [less ▲]

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See detailLa métropolisation, une nouvelle donne
Merenne-Schoumaker, Bernadette ULg

in Acta Geographica Lovaniensia (1994), (34), 165-174

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has ... [more ▼]

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has tackled successively four points: the concepts of metropolis and metropolization, the metropolization process, the metropolization and the city systems, the metropolization in Europe and Belgium. [less ▲]

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See detailOxygen Transport Chain in Double-Muscled Blue Belgian Cattle
Lekeux, Pierre ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in British Veterinary Journal (The) (1994), 150(5, Sep-Oct), 463-471

The physiological peculiarities of the oxygen transport chain in double-muscled Blue Belgian cattle are described. The investigations performed at several levels of the oxygen transport chain suggest that ... [more ▼]

The physiological peculiarities of the oxygen transport chain in double-muscled Blue Belgian cattle are described. The investigations performed at several levels of the oxygen transport chain suggest that the increased susceptibility of these cattle to stress, resulting mainly in respiratory diseases, is due to an insufficient functional reserve capacity mainly involving the pulmonary and cardiovascular systems. The resulting lack of 'functional hardiness' of the oxygen transport chain is seen in those double-muscled cattle which do not react in an appropriate or predictable way when submitted to a hostile environment. [less ▲]

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See detailMolecular Analysis Of The Ycr-242 Gene Encoding The Putative Mitochondrial Asparaginyl-Transfer-Rna Synthetase From Saccharomyces-Cerevisiae
Landrieu, I.; Vandenbol, Micheline ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailGeometric control of a pyridoxal-catalyzed aldol condensation
Koh, John T.; Delaude, Lionel ULg; Breslow, Ronald

in Journal of the American Chemical Society (1994), 116(25), 11234-11240

A chiral cyclophane derivative of pyridoxal has been synthesized that has amino groups oriented specifically over one face of the cofactor. The compound catalyzes the formation of threonine and allo ... [more ▼]

A chiral cyclophane derivative of pyridoxal has been synthesized that has amino groups oriented specifically over one face of the cofactor. The compound catalyzes the formation of threonine and allo-threonine from glycine and acetaldehyde with enantioinductions that are a function of pH, reversing the optical selectivity between low pH and high pH. The stereochemical results are compared with those of structurally related pyridoxal cyclophanes that lack titratable catalytic groups. Explanations are advanced for this stereochemical reversal and for the otherwise surprising preference of most of these compounds to react on the more hindered face of the pyridoxal. Models indicate that the transamination intermediate is distorted by the transannular chain, and stereoelectronic arguments predict that this distortion should lead to reaction on the face that carries the chain, as observed. The stereochemical reversal with the attached (dimethylamino)alkyl group, as a function of pH, may reflect catalysis by the protonated form, but metal coordination by the basic form cannot be excluded. [less ▲]

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See detailOptimisation du plan parcellaire d'une exploitation agricole: une application de la theorie des graphes.
Dupont, Pascal ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(3),

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See detailVerticalization of behavior elicited by dopaminergic mobilization is qualitatively different between C57BL/6J and DBA/2J mice
Tirelli, Ezio ULg; Witkin, J. M.

in Psychopharmacology (1994), 116(2), 191-200

Behavioral effects of dopaminergic stimulation were compared for C57BL/6J mice and DBA/2J mice. Effects of apomorphine (APO) alone and in combination with cocaine (COC) were assessed using a time-sampling ... [more ▼]

Behavioral effects of dopaminergic stimulation were compared for C57BL/6J mice and DBA/2J mice. Effects of apomorphine (APO) alone and in combination with cocaine (COC) were assessed using a time-sampling technique that classified climbing and leaning in separate categories. Climbing occurred in DBA/2J mice only at doses of APO that were 16 times higher than the smallest effective dose in C57BL/6J mice, but relative to baseline values, effects were comparable. Whereas DBA/2J mice showed dose-dependent leaning under APO, C57BL/6J mice exhibited significantly increased leaning only after the highest APO dose. When given alone, COC produced significant climbing, but not leaning or gnawing, in either strain. COC potentiated APO-induced climbing and gnawing in both strains but did not consistently change APO-induced leaning in either strain. APO alone reduced locomotor activity and attenuated COC-induced hyperkinesia. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailPilot trial of combined administration of erythropoietin and granulocyte colony-stimulating factor to children undergoing allogeneic bone marrow transplantation.
Locatelli, F.; Zecca, M.; Ponchio, L. et al

in Bone Marrow Transplantation (1994), 14(6), 929-35

We carried out a pilot study to evaluate the combined use of recombinant human erythropoietin (rhEpo) and granulocyte colony-stimulating factor (G-CSF) for accelerating marrow engraftment in children ... [more ▼]

We carried out a pilot study to evaluate the combined use of recombinant human erythropoietin (rhEpo) and granulocyte colony-stimulating factor (G-CSF) for accelerating marrow engraftment in children given allogeneic bone marrow transplantation (BMT). Fifteen consecutive children were enrolled in this study; 13 completed it and were evaluable. Using analysis of variance, laboratory and clinical data referring to these children were compared with those of 15 patients previously treated with rhEpo alone and with those of 16 historical controls. Erythroid repopulation, evaluated sequentially through serum transferrin receptor and reticulocyte count, was similarly accelerated in children receiving rhEpo alone and in those receiving combined treatment. These latter, however, showed a further reduction in the total number of red blood cell units required to reach transfusion independence (1.1 +/- 0.7 in the study population vs 2.7 +/- 1.2 in rhEpo group vs 4.2 +/- 2.3 in historical controls; values are mean +/- 1 SD; p < 0.001). Neutrophil engraftment, i.e. time for neutrophils to reach 0.5 x 10(9)/l, was 11 +/- 3 days in children receiving combined treatment, significantly shorter than that of the control groups (16 +/- 3 and 18 +/- 5, respectively; p < 0.001). Acceleration of neutrophil recovery translated into fewer infections: days of fever were significantly reduced in the study population (4 +/- 2 vs 11 +/- 8 vs 15 +/- 6, respectively).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailMax Ophuls : le cristal et la tache
Belloi, Livio ULg

in Cinémathèque (1994), 6(automne),

Cette étude porte sur les quatre derniers films de Max Ophuls ("La Ronde", "Le Plaisir", "Madame de" et "Lola Montès") et s'attache à révéler, en eux, une forme de dilemme du visible (entre transparence ... [more ▼]

Cette étude porte sur les quatre derniers films de Max Ophuls ("La Ronde", "Le Plaisir", "Madame de" et "Lola Montès") et s'attache à révéler, en eux, une forme de dilemme du visible (entre transparence et opacité) que la modernité cinématographique inscrira résolument à son ordre du jour. [less ▲]

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See detailParametric Cubic Equations For Modeling Moldboard Plow Surfaces
Ravonison, Nm.; Destain, Marie-France ULg

in Soil & Tillage Research (1994), 31(4), 363-373

Mouldboard shape identification is needed to compare and analyse the performance of different plough bottoms. The paper presents a method for describing an existing mouldboard mathematically. The ... [more ▼]

Mouldboard shape identification is needed to compare and analyse the performance of different plough bottoms. The paper presents a method for describing an existing mouldboard mathematically. The technique used is based on a Bezier form of three dimensional parametric cubics and it focuses on an algorithm to improve the efficiency of approximation of a theoretical surface and the actual one. The method is well suited to describing mouldboard designs. [less ▲]

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See detailDe limite en frontière : le monde à la mesure de l'homme
Bachelet, Jean-François ULg

in Revue de l'Institut de Sociologie (1994), 3-4

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See detailLa maladie de Lyme : une nouvelle maladie?
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailAnevrysme femoral superficiel rompu dans le cadre d'une neurofibromatose. A propos d'un cas
Van Damme, Hendrik ULg; Deprez, Manuel ULg; De Leval, Laurence ULg et al

in Journal des Maladies Vasculaires (1994), 19(1), 62-5

The authors observed the spontaneous rupture of a dysplastic superficial femoral artery in a 47 years old patient with Von Recklinghausen disease. The patient presents a gigantism of his right lower limb ... [more ▼]

The authors observed the spontaneous rupture of a dysplastic superficial femoral artery in a 47 years old patient with Von Recklinghausen disease. The patient presents a gigantism of his right lower limb. On angiography, the femoropopliteal axis is polyaneurysmal and there is evidence of rupture at mid-thigh. The diseased artery is excluded by interposition of a dacron prosthesis, with reimplantation of the deep femoral artery. Histology shows fibrohyalin thickening of the intima. Dysplasia of large limb arteries is excessively rare in Von Recklinghausen disease. [less ▲]

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See detailMultiphase Saturation Curves of the Oxoglutarate Carrier : A mathematical Model
Holzhütter, H.-G.; Sluse-Goffart, C.; Sluse, Francis ULg

in Mathematical & Computer Modelling (1994), 19(6-8), 263-272

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See detailEffect of the emulsion stability on the morphology and porosity of semicrystalline poly-L-lactide micriparticles prepared by w/o/w double emulsion-evaporation
Schugens, Ch; Laruelle, N; Nihant, N et al

in Journal of Controlled Release (1994), 32

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See detailMeasurement of Right Ventricular Ejection Fraction and Volume by the Thermodilution Technique in the Unsedated Calf
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1994), 56(1), 75-81

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end ... [more ▼]

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in unsedated cattle. In the 16 healthy calves studied, it was possible, using a fast response thermodilution catheter, to obtain characteristic exponential steplike washout curves, allowing the calculation of right ventricular EF, EDV and ESV. Five to 10 successive thermodilution curves were recorded within a few minutes and two to five similar sets of measurements were performed throughout the same day to test the reproducibility of the technique. The same protocol was repeated the following day. Right ventricular EF, EDV and ESV were reproducible successively, throughout a given day and on following days. The mean intraset, intraday and interdays coefficients of variation ranged from a mean of 4.0 (SD 4.1) per cent to a mean of 18.2 (SD 7.9) per cent. Values of right ventricular volumes and EF agreed with those previously reported in various animal species. Thermodilution was, therefore, shown to be a useful method for measuring with a satisfactory reproducibility, right ventricular EF, EDV and ESV in the unsedated healthy calf [less ▲]

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See detailPyoverdine production is not the sole trait involved in the biological control of soil diseases by Pseudomonas fluorescens ATCC 17400.
Jacques, Ph.; Cornelis, P.; Gaballa, A. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1994), 102(B81),

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See detailFunctional Sites Of The Bovine Leukemia-Virus Envelope Glycoproteins Using Structural And Immunological Data
Callebaut, I.; Mornon, Jp.; Burny, A. et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailCo-movements and dynamic interrelationships in pacific basin stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza; Urbain, Jean-Pierre ULg

in Research in International Business and Finance (1994), 11B

In this paper, we investigate dynamic interrelationships among the stock markets of Australia, Hong Kong, Japan, New Zealand and Singapore. Using cointegration analysis and the Granger causality test we ... [more ▼]

In this paper, we investigate dynamic interrelationships among the stock markets of Australia, Hong Kong, Japan, New Zealand and Singapore. Using cointegration analysis and the Granger causality test we find that, although the five stock price indices share some common trends, the only stock price which does not apparently Granger cause (precede) the remaining stock prices is that of New Zealand. It is further observed that all price indices are caused by the remaining stock prices except that of Australia. With respect to the geographical separation, it appears that when we consider the Asian countries as an entity and those of the Pacific as another entity, they seem not to influence each other significantly. [less ▲]

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See detailLes méthodes d'analyse factorielle : principes et applications
Palm, Rodolphe ULg

in Biométrie-Praximétrie (1994), 34

This note describes in a simple way the principles of the factorial methods, and more particularly of the principal component anlaysis and the correspondence analysis. The emphasis is put on the elements ... [more ▼]

This note describes in a simple way the principles of the factorial methods, and more particularly of the principal component anlaysis and the correspondence analysis. The emphasis is put on the elements useful when interpreting the results of an analysis and the methods are illustrated by completely worked out examples. [less ▲]

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See detailCell localization and redistribution of the 67 kD laminin receptor and alpha 6 beta 1 integrin subunits in response to laminin stimulation: an immunogold electron microscopy study.
Romanov, V.; Sobel, M. E.; pinto da Silva, P. et al

in Cell Adhesion and Communication (1994), 2(3), 201-9

The 67 kDa laminin receptor (67LR), one of several cell surface laminin-binding proteins, is involved in the interactions between cancer cells and laminin during tumor invasion and metastasis. A 37 kDa ... [more ▼]

The 67 kDa laminin receptor (67LR), one of several cell surface laminin-binding proteins, is involved in the interactions between cancer cells and laminin during tumor invasion and metastasis. A 37 kDa polypeptide (37LRP), previously identified as the 67LR precursor, is abundantly present in the cytoplasm and has been implicated in polysome formation. To better understand the cellular localization of the 67LR and its precursor, transmission electron microscopic studies of human melanoma A2058 cells were carried out using immunogold labeling and a variety of antibodies: (a) affinity purified antibodies directed against 37LRP cDNA-derived synthetic peptides; (b) anti-67LR monoclonal antibodies raised against intact human small cell lung carcinoma cells; and (c) monoclonal antibodies against the subunits of the integrin laminin receptor, alpha 6 beta 1. Double-labeling immunocyto-chemistry revealed that anti-67LR monoclonal antibodies as well as anti-37 LRP antibodies recognized antigens that were localized in the cytoplasm in electron dense structures. As expected, cell membrane labeling was also observed. Surprisingly, alpha 6 and beta 1 integrin subunits were detected in the same cytoplasmic structures positive for the 67LR and the 37LRP. After addition of soluble laminin to A2058 cells in suspension, the number of labeled cytoplasmic structures increased especially in the vicinity of the plasma membrane, and were exported onto the cell surface. Neither fibronectin nor BSA induced such an effect. The data demonstrate that the 67 LR and the 37 LRP antibodies detect colocalized antigens that are in cytoplasmic structures with alpha 6 beta 1 integrin.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailFood Consumption in Belgium
Reginster-Haneuse, G.; Gosset, Christiane ULg

in Bibliotheca Nutritio et Dieta (1994), (51), 108-12

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See detailResonance transitions in Neutral Chlorine
Biémont, Emile ULg; Gebarowski, R.; Zeippen, C. J.

in Astronomy and Astrophysics. Supplement Series (1994), 287

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See detailBovine Leukemia Virus
Kettmann, Richard ULg; Burny, A.; Callebaut, I. et al

in The Retroviridae (1994)

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See detailGénétique moléculaire des récepteurs olfactifs
Parmentier, M.; Vanderhaeghen, P.; Schurmans, Stéphane ULg et al

in Medecine Sciences : M/S (1994), 10

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des ... [more ▼]

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des récepteurs à sept passages transmembranaires couplés, par l'intermédiaire de protéines G, à l'activation de l'adénylyl cyclase et de la phospholipase C. La grande diversité des récepteurs olfactifs réside surtout dans les domaines transmembranaires III, IV, V et VI, qui portent les sites de liaison des ligands, les molécules odorantes, et répond sans doute à la diversité des ligands [less ▲]

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See detailEst-ce ainsi que les jeunes Belges lisent? Résultat d'une enquête internationale
Lafontaine, Dominique ULg; Lafontaine, Annette ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1994), 31(7), 31

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See detailA Consistent next-to-leading order QCD calculation of hadronic diffractive scattering
Cudell, Jean-René ULg; Nguyen, Bao

in Nuclear Physics B (1994), 420

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See detailLa régionalisation du droit pénal international
Flore, Daniel ULg; Thomas, F.

in Revue internationale de droit pénal (1994)

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See detailEloge de Marcel Migeotte (1912-1992)
Biémont, Emile ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1994), V(6), 271-278

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See detailReduction of the acute bioavailability of metformin by the alpha-glucosidase inhibitor acarbose in normal man.
Scheen, André ULg; de Magalhaes, A. C.; Salvatore, T. et al

in European Journal of Clinical Investigation (1994), 24 Suppl 3

In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy ... [more ▼]

In a double-blind cross-over study, we investigated a possible influence of the alpha-glucosidase inhibitor acarbose on the bioavailability of the biguanide compound metformin. Each of the six healthy young male volunteers was randomly allocated during two consecutive 7 day periods to either acarbose (days 1-3: 3 x 50 mg day-1; days 4-7: 3 x 100 mg day-1) or placebo. At day 7 and 14 of the study, the overnight-fasted subjects ingested 1000 mg metformin with the first bite of a standardized breakfast (500 kcal; 60 g carbohydrates) and together with either placebo or 100 mg acarbose. Acarbose significantly (P < 0.05) reduced the meal-induced increase in blood glucose and plasma insulin levels. Acarbose induced a significant (P < 0.05) reduction in early (90, 120, 180 min) serum levels, peak concentrations (Cmax: 1.22 +/- 0.14 vs. 1.87 +/- 0.60 mg l-1) and area under the curve of metformin (AUC 0-540 min: 423 +/- 55 vs. 652 +/- 55 mg min l-1), but did not diminish its 24 h urinary excretion. In conclusion, acarbose significantly reduces the acute bioavailability of metformin in normal subjects. [less ▲]

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See detailPolylactide Microparticules Prepared by Double Emulsion/Evaporation Technique. I. Effect of Primary Emulsion Stability
Nihant; Schugens, Chantal; Grandfils, Christian ULg et al

in Pharmaceutical Research (1994), 11(10), 1479-1484

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound ... [more ▼]

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound is emulsified into an organic solution of the hydrophobic coating polymer; second, this primary water-in-oil (w/o) is dispersed in water with formation of a double water-oil-water emulsion (w/o/w), third, the organic solvent is removed with formation of solid microparticles. This paper focuses of the effect of primary emulsion stability on the morphology and properties of polylactide microparticles loaded with bovine serum albumin (BSA) used as model drug. [less ▲]

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See detailUn affranchi trop discret? : A propos des lignes 13-19 du P. Matr. Daris 2
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1994), LXIX(137), 127-131

Born of manumitted parents, Sarapion introduice himself as a freeborn though he too is a freedman. Observations on the way he got a patch of land and on the affective and sexual life of the slaves.

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See detailThymus Involvement in Murine Acquired Immunodeficiency (Maids)
Colombi, Sonia; Deprez, Manuel ULg; de Leval, Laurence ULg et al

in Thymus (1994), 23(1), 27-37

Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced ... [more ▼]

Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced cytopathic effects on T-cells in the periphery. Therefore, thymus weight, cell numbers, and subset distribution were sequentially analysed after infection with RadLV-Rs, a viral mixture known to induce murine retrovirus induced immunodeficiency (MAIDS). Infection induced thymic atrophy (concerning organ weight as well as total cell number) which culminated seven weeks after inoculation. The atrophic process mostly reflected the depletion of double positive CD4+ CD8+ cells since their proportion sharply decreased around week 6. Single positive T-cells were less affected by the process. The proportion of B-cells progressively increased. Surprisingly, there was a strong correlation between the extent of atrophy and the frequency of B-cells in the thymus. Finally, an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in the periphery also appeared in the thymus and its frequency was strongly correlated with the expansion of B-cells in this organ. [less ▲]

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See detailLe tamoxifene dans le traitement du cancer du sein
Charlier, Corinne ULg; Colin, Claude ULg; Merville, Marie-Paule ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(7), 751-6

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on ... [more ▼]

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on oral adjuvant therapy in the early stages of breast cancer. A significative regression of the tumour was observed in most cases. Moreover, recent epidemiological studies suggest that tamoxifen could prevent new contralateral primary tumours. The risk of the disease should thus be reduced by the prophylactic use of antioestrogens such as tamoxifen. Investigations using a variety of models have evaluated the effect of tamoxifen on tumour promotion and cell growth. Tamoxifen-induced growth inhibition is associated with major changes in biochemical events in cultured human breast cancer cells including cell proliferation or growth factor production. Growth inhibition of oestrogen-responsive human breast cancer cells is associated with an induced secretion of autoinhibitory polypeptides (TGF beta) and an antagonistic effect on the synthesis of proliferative proteins (TGF alpha,...). The first step in the mechanism of action of the drug is binding of tamoxifen to the oestrogen receptors. Development of resistance to tamoxifen treatment is a great problem in treatment of breast cancer patients and the mechanism of resistance will require further study: under the influence of the drug, tumours could become remodelled as selected subpopulations emerge resistant-tamoxifen. The fact that some breast cancers which are oestrogen receptor-negative respond to antioestrogen suggests that parallel but separate pathways for oestrogen and antioestrogen action may exist. This paper summarizes the results of the most recent studies concerning this promising drug. [less ▲]

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See detailLes spermatozoïdes ont-ils du nez ?
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Parmentier, M. et al

in Medecine Sciences : M/S (1994), 10

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See detailA screening technique to isolate bacterial strains producing high molecular weight bacteriocins
Jabrane, A.; Destain, Jean-Pierre ULg; Compère, Philippe ULg et al

in Biotechnology Techniques (1994), 8(10), 751-754

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See detailCompte rendu de The Brunner Collection of Medieval Art
George, Philippe ULg

in Moyen Age (Le) (1994)

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See detailErythropoietic activity and iron metabolism in autologous blood donors during recombinant human erythropoietin therapy.
Biesma, D. H.; Van de Wiel, A.; Beguin, Yves ULg et al

in European Journal of Clinical Investigation (1994), 24(6), 426-32

The use of recombinant human erythropoietin (rhEPO) to intensify the erythropoietic response in autologous donors may reduce homologous blood requirement. We studied the effect of subcutaneous rhEPO (500 ... [more ▼]

The use of recombinant human erythropoietin (rhEPO) to intensify the erythropoietic response in autologous donors may reduce homologous blood requirement. We studied the effect of subcutaneous rhEPO (500 U kg-1 body weight twice weekly during a 3 week period) on variables of erythropoiesis and iron metabolism in 62 autologous blood donors, of whom 32 received rhEPO (epo group) and 30 did not (control group). Patients donated only 2 units of blood and received oral iron in order to restrict phlebotomy-induced decrease of iron stores. Pre-phlebotomy haemoglobin concentration (14.0 +/- 0.8 g dl-1) was completely regenerated in the epo group at surgery (13.7 +/- 1.3 g dl-1); haemoglobin concentration in the control group fell from 13.5 +/- 1.4 g dl-1 to 11.6 +/- 1.4 g dl-1 after the phlebotomies and did not improve during the pre-operative phase. Total erythropoietic activity expressed as serum transferrin receptor concentration (sTfR) showed a 4-fold increase from 3.8 +/- 0.9 micrograms ml-1 to 14.9 +/- 4.8 micrograms ml-1 in the epo group. Effective erythropoietic activity measured by absolute reticulocyte count, however, declined after the fourth rhEPO injection in the epo group. Serum ferritin was lower in the epo group, but no differences in serum iron, transferrin concentration and transferrin saturation were observed between the groups. A marked increase in free erythrocyte protoporphyrin (FEP) was observed in the epo group, whereas FEP levels in the controls remained within normal ranges. Despite oral iron supplementation and the limited number of phlebotomies, the effect of rhEPO therapy in autologous donors is restricted by iron depletion. [less ▲]

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See detailItinéraire d’une fable : le Loup et le Chien
Pietquin, Paul ULg; Dachy, Françoise; Debrux, Thomas et al

in Etudes Classiques (Namur, Belgium) (1994), 62

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See detailInactivation of alpha(2)-Macroglobulin by Activated Human Polymorphonuclear Leukocytes.
Deby, Ginette ULg; Croisier, Jean-Louis ULg; Camus, Gérard et al

in Mediators of Inflammation (1994), 3(2), 117-23

The proteolytic activity of trypsin releases the dye Remazol Brilliant Blue from its high molecular weight substrate, the skin powder (Hide Powder Azure, Sigma), with an increase in absorbance at 595 nm ... [more ▼]

The proteolytic activity of trypsin releases the dye Remazol Brilliant Blue from its high molecular weight substrate, the skin powder (Hide Powder Azure, Sigma), with an increase in absorbance at 595 nm. Active alpha(2)- macroglobulin (80 mug/ml) totally inhibits the proteolytic activity of trypsin (14 mug/ml) by trapping this protease. But after a 20 min incubation of alpha(2)-macroglobulin at 37 degrees C with 2 x 10(6) human polymorphonuclear leukocytes activated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (10(-7) M) and cytochalasin B (10(-8) M), 100% of trypsin activity was recovered, indicating a total inactivation of alpha(2)-macroglobuHn. Incubation with granulocyte myeloperoxidase also inactivates alpha(2)-macroglobulin. Hypochlorous acid, a by-product of myeloperoxidase activity, at a concentration of 10(-7) M also inactivates alpha(2)-macroglobulin, which indicates that an important cause of alpha(2)-macroglobulin inactivation by activated polymorphonuclear leukocytes could be the activity of myeloperoxidase. [less ▲]

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See detailAspects of the ecology of the wood-inhabiting fungi of Laing Island (Papua New Guinea)
Castillo Cabello, Gabriel ULg; Demoulin, Vincent ULg

in Belgian Journal of Botany (1994)

Dans le cadre d'une étude sur l'écologie des champignons lignicoles de l'île de Laing (Papouasie Nouvelle-Guinée), les espèces les plus fréquemment rencontrées (en particulier: Schizophyllum commune ... [more ▼]

Dans le cadre d'une étude sur l'écologie des champignons lignicoles de l'île de Laing (Papouasie Nouvelle-Guinée), les espèces les plus fréquemment rencontrées (en particulier: Schizophyllum commune, Daldinia eschscholzii et Trametes scabrosa) ont été cartographiées. Les résultats montrent qu'il existe une bonne corrélation entre le type de répartition des champignons et le degré de couverture végétale. In the framework of a study of the ecology of wood-inhabiting fungi on Laing Island (Papua New-Guinea), the most frequently occurring species (namely Schizophyllum commune, Daldinia eschscholzii and Trametes scabrosa) were mapped. The results show a good correlation between the distribution of the fungi and the degree of vegetation cover. [less ▲]

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See detailUse of recombinant human erythropoietin after bone marrow transplantation in pediatric patients with acute leukemia: effect on erythroid repopulation in autologous versus allogeneic transplants.
Locatelli, F.; Zecca, M.; Pedrazzoli, P. et al

in Bone Marrow Transplantation (1994), 13(4), 403-10

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) in children undergoing allogeneic or mafosfamide-purged autologous BMT for ALL or AML. rHuEPO was administered ... [more ▼]

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) in children undergoing allogeneic or mafosfamide-purged autologous BMT for ALL or AML. rHuEPO was administered intravenously at a dose of 75 U/kg/day for 30 days after transplant. Ten rHuEPO-treated patients receiving allogeneic BMT and 10 given autologous BMT were compared with 15 allogeneic and 10 autologous historical controls. Endogenous EPO production was appropriate for the degree of anemia after autologous BMT. In these patients, rHuEPO did not accelerate erythroid repopulation and did not modify transfusion requirements. With allogeneic BMT, erythroid marrow activity increased faster in patients given rHuEPO than in controls and resulted in higher red cell production, the mean reticulocyte count on day +30 being 187 +/- 51 x 10(9)/l in treated patients versus 107 +/- 63 x 10(9)/l in controls (p < 0.01). The total number of RBC units administered was 1.7 +/- 1.3 in the rHuEPO group versus 5.1 +/- 3.0 in the control group (p < 0.001). The total number of platelet transfusions was 4.0 +/- 2.3 for patients given allogeneic BMT and receiving rHuEPO versus 8.4 +/- 6.8 for historical controls (p < 0.05) whereas it was similar in rHuEPO-treated and control autologous BMT patients.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailExperimental Models of Inflammatory Bowel Disease
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1994), 57(5-6, Sep-Dec), 306-9

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced ... [more ▼]

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced models. Spontaneous models are infectious, genetic or of unknown etiology. Induced models are infectious, immune-mediated, chemical or genetic. All these models share some characteristics with IBD. In general, they are characterized by a chronic inflammation of the gut, and often, this inflammation appears secondary to mucosal abnormalities leading to an abnormal immune and inflammatory response toward luminal material. The most interesting models are thus those that share not only clinical and pathological characteristics with IBD, but also early mucosal abnormalities. From that point of view, the nonsteroidal anti-inflammatory drug (NSAID) enteropathy is probably one of the most interesting model for Crohn's disease (CD). In effect, this model shares an early modification with CD, that is increased intestinal permeability. In animals NSAID enteropathy, the increased intestinal permeability appears early after NSAID administration and is followed by inflammatory lesions. These lesions seem to be secondary to the increased permeability and depend on intraluminal materials, such as alimentary antigens or bacterial fragments. A possible link between the increased permeability and the inflammatory lesions could be an abnormal immune and inflammatory response toward the intraluminal materials. If the increased intestinal permeability in CD was confirmed, the same mechanisms could be implicated in its pathophysiology. [less ▲]

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See detailCompte rendu de Mélanges Gabriel Sanders
George, Philippe ULg

in Moyen Age (Le) (1994)

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See detailAcute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study.
Dahchour, Abdelkhader; Quertemont, Etienne ULg; De Witte, Philippe

in Alcohol & Alcoholism (1994), 29(5), 485-7

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain ... [more ▼]

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain nucleus accumbens were studied by the microdialysis technique coupled to HPLC-EC detection. Levels of GLU and GABA were not affected by ethanol, whereas those of TAU were increased by doses of the drug of 2-3 g/kg. [less ▲]

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See detailSyndrome naviculaire : anatomie, étio-pathogénie, diagnostic et traitement
Gabriel, Annick ULg; Caudron, I.; Serteyn, Didier ULg et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailLe diabète insipide central : l'étiologie n'est pas toujours évidente
Geenen, Vincent ULg

in Actualité Médicale Belge (1994), 444

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See detailMeasurement of insulin sensitivity by the minimal model method using a simplified intravenous glucose tolerance test: validity and reproducibility.
Duysinx, Bernard ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Diabète & Métabolisme (1994), 20(4), 425-32

This study aimed at testing whether 12 rather than 26 plasma glucose and insulin determinations can be used to calculate the indices of insulin sensitivity and of glucose effectiveness using Bergman's ... [more ▼]

This study aimed at testing whether 12 rather than 26 plasma glucose and insulin determinations can be used to calculate the indices of insulin sensitivity and of glucose effectiveness using Bergman's minimal model during a simple intravenous glucose tolerance test performed without tolbutamide injection. Two intravenous glucose tolerance tests (separated by 1 week) were performed in 7 lean normal subjects and a single test was performed in 9 severely obese non-diabetic subjects. Intra-subject reproducibility of insulin sensitivity was not significantly different when 26 or 12 time-points were analyzed (CV = 16.8 +/- 3.4 versus 18.9 +/- 3.8% respectively). Compared with the insulin sensitivity of the lean subjects, that of obese subjects was significantly (P < 0.001) and similarly reduced when using 12 (2.14 +/- 0.34 versus 7.97 +/- 1.29 10(-4)min-1/mU.1-1) rather than 26 determinations (2.13 +/- 0.42 versus 6.95 +/- 1.12 10(-4) min-1/mU.1-1) respectively. Glucose effectiveness was less reproducible than insulin sensitivity and was slightly diminished by the reduction of blood samples (relative error: -9.7 +/- 4.4%; P < 0.05). Finally, glucose effectiveness tended to be slightly lower in the morbidly obese subjects than in the lean controls with both modes of calculation. In conclusion, in non-diabetic subjects, the insulin sensitivity index can be accurately measured during a simple intravenous glucose tolerance test, without tolbutamide injection and with only 12 blood samples. The possibility of performing a simplified test should contribute to increase the use of the minimal model method for estimating insulin sensitivity in clinical practice. [less ▲]

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See detailA TEF-1 binding motif that interacts with a placental protein is important for the transcriptional activity of the hCS-B enhancer
Jacquemin, P.; Oury, Cécile ULg; Belayew, A. et al

in DNA & Cell Biology (1994), 13(10), 1037-45

The transcriptional activity of the human placental lactogen genes (choriosomatomammotropic hormone, hCS) is controlled by tissue-specific enhancers located 4 kb downstream from their respective origins ... [more ▼]

The transcriptional activity of the human placental lactogen genes (choriosomatomammotropic hormone, hCS) is controlled by tissue-specific enhancers located 4 kb downstream from their respective origins of transcription. The hCS-B enhancer is the strongest; its activity is mediated by synergism between two protein-binding sites (DF-3 and DF-4). The DF-4 site possesses a potential binding sequence for TEF-1, a known transcription factor. In this paper, we show by electrophoretic mobility-shift assays and antibody supershift experiments that TEF-1 does not bind to site DF-4. Mutations in the TEF-1-like binding motif of site DF-4 prevent formation of the DNA-protein complex, called complex f, in the presence of placental JEG-3 cell extracts. When HeLa cell extracts are used, another complex (complex c) is also affected. In transient expression experiments, TKCAT constructs linked to this mutated DF-4 site exhibit greatly reduced transcriptional activity when introduced into JEG-3 cells. Some cell lines contain both protein c and protein f (the proteins forming complexes c and f); when transfected, these lines display reduced DF-4-driven activity, suggesting that the two proteins could compete for the same DF-4 sequence. We conclude that protein f is important for the placenta-specific activity of the hCS-B enhancer. By UV cross-linking, we show that protein f is actually three polypeptides ranging in size from about 12 to 21 kD. [less ▲]

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See detailDie Devon/Karbongrenze bei Stockum (Rheinisches Schiefergebirge).
Clausen, C.D.; Korn, D; Feist, R et al

in Geologie und Paläontologie in Westfalen (1994), 29

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See detailDo canine scalene and sternomastoid muscles play a role in breathing?
De Troyer, A.; Cappello, M.; Brichant, Jean-François ULg

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1994), 76(1), 242-52

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on ... [more ▼]

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on the electrical activity of these muscles in 18 supine anesthetized spontaneously breathing animals. The sternomastoids never showed any activity, and the scalenes showed some inspiratory activity during occlusion in only two animals. The adoption of the prone position and bilateral cervical vagotomy did not affect this pattern. Hypercapnia also did not elicit any sternomastoid activity and induced scalene inspiratory activity during occlusion in only four of nine animals. On microscopic examination, however, both muscles were found to contain large numbers of spindles, suggesting that they have the capacity to respond to stretch. In addition, with increases in inspiratory resistance, both the sternum and ribs were displaced in the caudal direction. As a result, the scalenes demonstrated a gradual inspiratory lengthening and the normal inspiratory lengthening of the sternomastoids was accentuated. Additional studies in three unanesthetized animals showed consistent activity in the scalene and sternomastoid muscles during movements of the trunk and neck but no activity during breathing, including occluded breathing. These observations thus indicate that the alpha-motoneurons of the scalene and sternomastoid muscles in the dog have very small central respiratory drive potentials with respect to their critical firing threshold. In this animal, these muscles do not have a significant respiratory function. [less ▲]

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See detailSpecific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.
Laptev, A. V.; Lu, Z.; Colige, Alain ULg et al

in Biochemistry (1994), 33(36), 11033-9

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system ... [more ▼]

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system consisted of mouse NIH 3T3 fibroblasts that were stably transfected with a human minigene for procollagen I so that the cells simultaneously synthesized full-length mouse pro alpha 1 (I) chains and internally deleted human pro alpha 1 (I) chains. The sequences of the transcripts from both genes were compared, and a series of 28 ASOs were designed to target sites in which there were at least two base differences within a 20-nucleotide sequence between the human and mouse transcripts. Six of the ASOs specifically decreased the levels of pro alpha 1 (I) chain synthesized from the human gene without a decrease in the levels of pro alpha 1 (I) chains from the mouse endogenous gene. The most effective ASOs reduced the intracellular levels of human pro alpha 1 (I) chains relative to the mouse pro alpha 1 (I) chains to 37-67% of the control values. Combined addition of two effective ASOs or a second administration of the same effective ASO did not produce any additive effect. The results did not support previous suggestions that the best target sites for ASOs were sequences around initiation codons for translation, at intron-exon boundaries, or in single-stranded loops in hairpin structures. Also, the results did not support previous suggestions that the most effective ASOs are those with the highest affinities for their target sequences. Instead, the most consistent pattern in the data was that the most effective ASOs were those targeted to sequences that were predicted to form clustered double-stranded structures in RNA transcripts. [less ▲]

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See detailUtilisation des moules comme bioindicateurs de la pollution en métaux lourds du littoral belge
Gobert, Sylvie ULg; Langer, Alain; Daemers-Lambert, Claire et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 203-210

From 1991 till 1993, a study of the Belgian coast pollution by heavy metals using Mytilus edulis as a bioindicator was performed. The Pb, Cr, Cu and Ti concentrations decreased from 1987 till 1991 but ... [more ▼]

From 1991 till 1993, a study of the Belgian coast pollution by heavy metals using Mytilus edulis as a bioindicator was performed. The Pb, Cr, Cu and Ti concentrations decreased from 1987 till 1991 but then remained unchanged till 1993. Cd contamination is increasing from 1987. Hg, whose concentration had been shown to decrease from 1975 to 1991, now reaches the same values as in 1986. The O/N measurements performed on the mussels suggest an increase of the general pollution level of the Belgian coast. However, feeding, spawning and detoxification processes are also able to influence the O/N ratio and should be taken into account in the framework of a global assessment of the pollution level of the Belgian coast [less ▲]

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See detailControl of the Illegal Administration of Natural Steroid Hormones in the Plasma of Bulls and Heifers
Scippo, Marie-Louise ULg; Degand, Guy ULg; Duyckaerts, Anne et al

in Analyst (1994), 119(12), 2639-44

In the context of the control of the illegal administration of natural steroid hormones in cattle husbandry, an attempt was made to establish the decision levels for sex steroid hormones in the plasma of ... [more ▼]

In the context of the control of the illegal administration of natural steroid hormones in cattle husbandry, an attempt was made to establish the decision levels for sex steroid hormones in the plasma of adult cattle, taking into account the effect of the treatment. Bulls and heifers were treated with two injections, at a two week interval, of an estradiol-testosterone cocktail. Steroid hormone and biochemical precursor concentrations were measured in plasma samples by using specific radioimmunoassays, before and after the treatment. When the treatment significantly (p < 0.05) modified a hormone concentration, a decision level was established for that hormone concentration. At each decision level, a score was assigned that represented the percentage of treated animals detected when the decision limit was applied. For heifers, 17 beta-estradiol and testosterone concentrations in plasma, which increased after the treatment, are the best criteria to use to detect treated animals, with decision limits of 20 pg ml-1 and 125 pg ml-1, respectively. In the instance of bulls, both testosterone and steroid biochemical precursor concentrations decreased in the plasma after the treatment. We proposed decision limits of 1500 pg ml-1 and 28 pg ml-1 for testosterone and androstenedione concentrations, respectively, the bulls displaying concentrations below these limits being positive. We observed that the repetition of the injection increased the score of the decision limit. The scores for testosterone are 70%, 14d after the first injection and 100% 14 d after the second injection, and for androstenedione, these scores are 60 and 100%, respectively. [less ▲]

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See detailEnergy Levels in Ar II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Physical Review. A (1994), 49

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See detailQuantitative and qualitative study of the production of broad-spectrum antifungal lipopeptides from Bacillus subtilis S499.
Jacques, Ph.; Hbid, Ch.; Vanhentenryck, F. et al

in Progress in biotechnology (1994), 9

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See detailHIGH-RESOLUTION SPECTRA OF JUPITER NORTHERN AURORAL ULTRAVIOLET EMISSION WITH THE HUBBLE-SPACE-TELESCOPE
TRAFTON, L. M.; Gérard, Jean-Claude ULg; Munhoven, Guy ULg et al

in Astrophysical Journal (1994), 421(2), 816-827

The first spectroscopic observations of planetary aurora with the HST are reported. These include spectral regions centered on the H-2 Lyman and Werner bands of a region of Jupiter's northern aurora. The ... [more ▼]

The first spectroscopic observations of planetary aurora with the HST are reported. These include spectral regions centered on the H-2 Lyman and Werner bands of a region of Jupiter's northern aurora. The observations were made with the Goddard High Resolution Spectrograph (GHRS) using the Large Science Aperture as part of a campaign to study Jupiter at the time of the Ulysses flyby. The individual rotational-vibrational bands are resolved and the observed emissions are essentially all from H-2. A rotational-vibrational temperature for H-2 of 530 +/- 100 K is derived, a value significantly less than the 850-1100 K reported for Jovian H-3(+) in the near-infrared but consistent with the temperature reported for fundamental-band quadrupole H-2 emission. Comparison with the Faint Object Camera (FOC) images shows that the observed region was not one of the hot spots of the aurora. The results are interpreted in terms of electron impact excitation of H-2 from secondary particles generated by primaries precipitating into Jupiter's atmosphere from the magnetosphere. In the region of the aurora observed, the homopause level is found to be significantly hotter but not necessarily higher than observed at nonauroral latitudes. The equatorial H-2 dayglow spectrum was also detected; its intensity was 3.2 kR or 13% of the strength of the observed auroral emission. [less ▲]

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See detailLe passage à la paternité: une approche clinique
Naziri, Despina ULg; Dragonas, Th.

in Psychiatrie de l'Enfant (La) (1994), 37(2), 601-629

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See detailCompte rendu de V. Langholf, Medical Theories in Hippocrates, Berlin-New York, 1990
Marganne, Marie-Hélène ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1994), 63

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See detailBénard-Marangoni instability in a viscoelastic Jeffreys' fluid layer
Lebon, Georgy ULg; Parmentier, Patrice; Teller, O. et al

in Rheologica Acta (1994), 33(4), 257-266

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See detailArt et technique
Duchesne, Jean-Patrick ULg

in Art&fact (1994), 13

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See detailComment on the paper "Oscillator Strengths for Some Systems with the ns2np ground-state configuration: II. Gallium Isoelectronic Sequence
Biémont, Emile ULg; Marcinek, R.; Migdalek, J. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1994), 27

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See detailNatural-Convection Above Line Heat-Sources In Greenhouse Canopies
Aubinet, Marc ULg; Deltour, Jules

in International Journal of Heat and Mass Transfer (1994), 37(12),

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See detailChoix d'une nouvelle variete pour les zones cotonnieres meridionales du Zaire. Resultats des essais varietaux preliminaires.
Mergeai, Guy ULg; Ndungo, V.; Folo, A. et al

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(4),

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See detailStructural Similarities Between Chaperone Molecules Of The Hsp60 And Hsp70 Families Deduced From Hydrophobic Cluster-Analysis
Callebaut, I.; Catelli, Mg.; Portetelle, Daniel ULg et al

in Febs Letters (1994), 342(3),

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See detailLa Formation de Pepinster dans le Synclinorium de Verviers, entre Perpinster et Eupen (Belgique)-Contexte structural et stratigraphique
Dejonghe, L; Steemans, Philippe ULg

in Annales de la Société Géologique de Belgique (1994), 117

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See detailLes défis des familles recomposées
Guillaume, Jean-François ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 6(novembre-décembre), 30-36

Dans un contexte de croissance des recompositions conjugales après divorce, la prise en charge des tâches parentales constitue un défi inédit, où il s'agit pour les uns de retrouver des repères bien ... [more ▼]

Dans un contexte de croissance des recompositions conjugales après divorce, la prise en charge des tâches parentales constitue un défi inédit, où il s'agit pour les uns de retrouver des repères bien connus, et pour les autres, d'imaginer un nouvel ordre éducatif. Une nouvelle histoire doit alors être créée, et dans ce "bricolage", chacun ne dispose pas des mêmes ressources pour trouver sa place. [less ▲]

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See detailComment évaluer la sensibilité à l'insuline en pratique?
Scheen, A. J.; Paquot, Nicolas ULg; Letiexhe, M. R. et al

in Diabète & Métabolisme (1994), 20(6, Nov-Dec), 556-61

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See detailIdentification Of Functional-Sites On Bovine Leukemia-Virus Envelope Glycoproteins Using Structural And Immunological Data
Callebaut, I.; Portetelle, Daniel ULg; Burny, A. et al

in European Journal of Biochemistry (1994), 222(2),

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See detailLe Marquis et les castrats. Note sur un tabou sadien
Durand, Pascal ULg

in Art&Fact (1994), 13

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See detailMicrostructural study of a zinc-aluminium-copper alloy after thermal treatment at 100°C and creep
Terziev, L.; Lecomte-Beckers, Jacqueline ULg; Wegria, J.

in Zeitschrift für Metallkunde (1994), 85[9]

The creep behaviour of the ternary Zn—A1—Cu alloy after thermal treatment at ioo oc has been studied. The applied creep stress does flot modify clearly the transition phases (OL, T% ‘11m) appearing during ... [more ▼]

The creep behaviour of the ternary Zn—A1—Cu alloy after thermal treatment at ioo oc has been studied. The applied creep stress does flot modify clearly the transition phases (OL, T% ‘11m) appearing during isothermal ageing. During the creep test, the formation of an important density of defects resuits in the precipitation of T’ and O’ particles. The quantity of these phases depends on the creep conditions. [less ▲]

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See detailAnalyses de sols et gestion de l'espace
Bock, Laurent ULg

in Etude et Gestion des Sols (1994), 1(1), 23-33

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See detailCharacterization of a single strong tissue-specific enhancer downstream from the three human genes encoding placental lactogen
Jacquemin, Patrick; Oury, Cécile ULg; Peers, Bernard ULg et al

in Molecular & Cellular Biology (1994), 14(1), 93-103

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3 ... [more ▼]

The human genes coding for growth hormone (hGH) and placental lactogen (choriosomatomammotropic hormone [hCS]) are clustered on chromosome 17 in the following order: 5' hGH-N hCS-L hCS-A hGH-V hCS-B 3'. So far, a single placenta-specific enhancer has been identified in the locus, 2 kb downstream from the hCS-B gene, and shown to comprise one in vitro binding site for a nuclear protein. We here provide evidence that the hCS-B enhancer is more complex: (i) protection against DNase I digestion in the 3' flanking region of the hCS-B gene reveals four binding sites (DF-1, DF-2, DF-3, and DF-4) for nuclear proteins from either placental or HeLa cells, and (ii) placenta-specific enhancer activity can be fully exerted in transient expression experiments by a 126-bp fragment comprising the DF-3 and DF-4 protein-binding sites. By dissecting this region, we show that enhancer activity is mediated by a synergy between DF-3 and DF-4. Competitions with various oligonucleotides in footprinting and gel retardation experiments indicate that the same protein or set of proteins, different in HeLa and placenta cell nuclei, interacts with sites DF-2, DF-3, and DF-4. We also studied the regions of the hCS-L and hCS-A genes which are highly similar to the hCS-B enhancer. Although they each present the same four protein-binding sites, they exhibit only minor enhancer activity. [less ▲]

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See detailHistoire naturelle des anévrysmes de l'aorte abdominale
SAKALIHASAN, Natzi ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1994), 49(10), 545-52

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See detailIdentification Of Distinct Potyviruses In Mixedly-Infected Sweet-Potato By The Polymerase Chain-Reaction With Degenerate Primers
Colinet, D.; Kummert, J.; Lepoivre, Philippe ULg et al

in Phytopathology (1994), 84(1),

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See detailPhylogenetic relationships among filamentous helical cyanobacteria investigated on the basis of 16S ribosomal RNA gene sequence analysis
Nelissen, Bart; Wilmotte, Annick ULg; Neefs, Jean-Marc et al

in Systematic & Applied Microbiology (1994), 17

The cyanobacterial genera Spirulina and Arthrospira are both characterized by helical trichomes but their taxonomy is controversial and a phylogenetic study is necessary. The sequence of the 16S rRNA gene ... [more ▼]

The cyanobacterial genera Spirulina and Arthrospira are both characterized by helical trichomes but their taxonomy is controversial and a phylogenetic study is necessary. The sequence of the 16S rRNA gene and the spacer between the 16S and 23S rRNA genes (ITS) was determined for three filamentous coiled cyanobacteria: Spirulina PCC 6313, Arthrospira PCC 7345 and Arthrospira PCC 8005. A distance tree based on the 16S rRNA sequences was constructed using the neighbor-joining method. This tree shows that the two Arthrospira strains are not closely related to the Spirulina strain but belong to a cluster of strains assigned to the genera Oscillatoria, Lyngbya, and Microcoleus. The strain Spirulina PCC 6313 belongs to a branching containing unicellular cyanobacteria. For the two Arthrospira strains, the sequenced ITS region contains the tRNA(Ile) and tRNA(Ala) genes, whereas the spacer region of strain Spirulina PCC 6313 contains only the tRNA(Ile) gene. [less ▲]

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See detailObservations de coupes dans la terrasse T3 dans la vallée du Niger en aval de Niamey
Willems, Luc ULg; Bergoing, Jean-Pierre

in Revue de Géographie Alpine (1994), 5

Dans la région de Niamey, l'étendue et le nombre d'affleurements du complexe T3, appelé aussi terrasse moyenne, permettent de dresser une chronologie relative des événements climatiques survenus dans la ... [more ▼]

Dans la région de Niamey, l'étendue et le nombre d'affleurements du complexe T3, appelé aussi terrasse moyenne, permettent de dresser une chronologie relative des événements climatiques survenus dans la région durant son édification. Une étude systématique révèle une grande diversité dans les dépôts souvent assimilable aux variations locales de sédimentation. Cependant, cinq épisodes majeurs dans l'édification du complexe peuvent être dégagés et correspondent à autant de fluctuations climatiques durant une période qui s'étendrait de 20 000 à 12 000 BP. La découverte et l'observation de diaclases ainsi que des phénomènes de soutirage dans les dépôts pléistocènes montrent le rôle important qu'a pu jouer la fracturation du socle birrimien sur l'ensemble de la morphologie actuelle de la région de Niamey, en particulier sur le réseau hydrographique. [less ▲]

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See detailAnalysis methodology, experimental investigation and computer optimization of a passive solar commercial building in the Belgian climate
Andre, Philippe ULg; Nicolas, Jacques ULg; Rivez, Jean-François et al

in Solar Energy (1994), 52(1), 9-25

The Fondation Universitaire Luxembourgeoise (FUL) building (completed in 1986) has been selected as a Belgian candidate for participation in the IEA (International Energy Agency) Task XI project devoted ... [more ▼]

The Fondation Universitaire Luxembourgeoise (FUL) building (completed in 1986) has been selected as a Belgian candidate for participation in the IEA (International Energy Agency) Task XI project devoted to passive solar commercial buildings. Therefore, an evaluation methodology has been set up and a monitoring plan has been defined and performed. Together with this experimental investigation, intensive computer simulation work has defined an optimized design of the building. The main results show that the recorded performance can be improved to an extent of 15% energy savings, which yields a correct performance for a passive solar building in the temperate maritime Belgian climate. [less ▲]

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See detailAnticorps anticytoplasme des polynucléaires neutrophiles (ANCA) dans les maladies inflammatoires du tube digestif
Lamproye, Anne ULg; Belaiche, Jacques ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (1994), 57(2, Mar-Apr), 171-6

Antineutrophil cytoplasmic antibodies have recently been demonstrated in sera of patients with inflammatory bowel disease. We are reporting here our experience among 94 patients with Crohn's disease and ... [more ▼]

Antineutrophil cytoplasmic antibodies have recently been demonstrated in sera of patients with inflammatory bowel disease. We are reporting here our experience among 94 patients with Crohn's disease and 25 with ulcerative colitis. The indirect immunofluorescence assay with alcohol fixed neutrophils has been used. The presence of antineutrophil cytoplasmic antibodies was significantly associated to the ulcerative colitis 61% VS 17% (p < 0.001). The fluorescence had a perinuclear pattern among all but one suffering from ulcerative colitis. Among the patients suffering from ulcerative colitis there was no relationship between the presence of antineutrophil cytoplasmic antibodies and the activity or the localisation of the disease. Among the 9 patients operated for their ulcerative colitis, 4 were ANCA positive and remained so after proctocolectomy. The existence of antineutrophil cytoplasmic antibodies is useful for the diagnosis of some unclassifiable colitis. Their presence may be used as an argument in favour of some disturbances of the immunoregulation of the disease. [less ▲]

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See detailLaparoscopic adrenalectomy in pheochromocytoma and Cushing's syndrome. Reflections about two case reports.
Meurisse, Michel ULg; Joris, Jean ULg; Hamoir, Etienne ULg et al

in Acta Chirurgica Belgica (1994), 94(6), 301-6

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open ... [more ▼]

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open method. In combination with intraoperative infusion of nicardipine, a calcium-channel blocker, the laparoscopic removal of a pheochromocytoma was performed safely and under stable conditions. In case of Cushing's syndrome, the laparoscopic approach reduces the problems related to poor healing. In all cases of laparoscopic adrenalectomy, this approach could offer the clear advantages of smaller incisions, reduced postoperative pain and incisional discomfort as well as complications related to large and invasive procedure and finally allows quicker recovery. Moreover, conversion to open surgery remains always possible, if needed. [less ▲]

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See detailFactors influencing between-laboratory variability of C-reactive protein results as evidenced by the Belgian External Quality Assessement (EQA) Scheme
Devleeschouwer, N.; Libeer, J. C.; Chapelle, Jean-Paul ULg et al

in Scandinavian Journal of Clinical & Laboratory Investigation (1994), 54(6), 435-40

Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using ... [more ▼]

Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using homogeneous systems with several calibration points generally achieved better performance. Working temperatures influenced the results to a lesser extent. The present study stresses the importance for EQA organizers to collect more detailed information about CRP analytical methods used by the participants. It also suggests that manufacturers should be more involved in the management of quality, in particular by striving for standardization of the material (kit and calibrator) they produce for CRP assay. [less ▲]

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See detailTechnique for Ventricular Wrapping in Experimental Dynamic Cardiomyoplasty
Radermecker, Marc ULg; Bonnet, Pierre ULg; Philippart, C. et al

in Acta Chirurgica Belgica (1994), 94(5, Sep-Oct), 266-71

Cardiomyoplasty is a wrapping of an electrostimulated latissimus dorsi muscle flap around the heart for substitution and/or reinforcement. The surgical technique for reproducible cardiomyoplasties in the ... [more ▼]

Cardiomyoplasty is a wrapping of an electrostimulated latissimus dorsi muscle flap around the heart for substitution and/or reinforcement. The surgical technique for reproducible cardiomyoplasties in the goat model is presented. The methods combine the direction of wrapping (clockwise, counter-clockwise) and the orientation of muscle fibers. A cardiomyoplasty model using right and left latissimus dorsi or left latissimus dorsi and pectoralis major as well as a split muscle technique are illustrated. [less ▲]

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See detailLa monadologie, une théorie de la communication basée sur l'opacité?
Bouquiaux, Laurence ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994)

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See detailCréer un programme de formation pour des professionnels de la Petite Enfance en Communauté germanophone de Belgique. Un enjeu pour le développement de la qualité de service.
Pirard, Florence ULg

in La Lettre. Formation. Développement local. L'accueil de la petite enfance: évaluation (1994), 3

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See detailANOMALOUS PERTURBATIVE TRANSPORT IN TOKAMAKS DUE TO DRIFT-ALVEN-WAVE TURBULENCE
Thoul, Anne ULg; SIMILON, P. L.; SUDAN, R. N.

in Physics of Plasmas (1994), 1(3), 601-608

The method developed in Thoul, Similon, and Sudan [Phys. Plasmas 1, 579 (1994)] is used to calculate the transport due to drift-Alfven-wave turbulence, in which electromagnetic effects such as the ... [more ▼]

The method developed in Thoul, Similon, and Sudan [Phys. Plasmas 1, 579 (1994)] is used to calculate the transport due to drift-Alfven-wave turbulence, in which electromagnetic effects such as the fluttering of the magnetic field lines are important. Explicit expressions are obtained for all coefficients of the anomalous transport matrix relating particle and heat fluxes to density and temperature gradients in the plasma. Although the magnetic terms leave the transport by trapped electrons unaffected, they are important for the transport by circulating electrons. [less ▲]

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See detailEpidemiological evaluation of a monoclonal ELISA detecting antibodies against bovine leukaemia virus in serum pools.
Knapen, K.; Kerkhofs, P.; Thiry, Etienne ULg et al

in Epidemiology & Infection (1994), 113(3), 563-9

Sensitivity, specificity and predictive values of an enzyme-linked immunosorbent assay (ELISA) for detecting antibodies against bovine leukaemia virus (BLV) were evaluated using a representative sample of ... [more ▼]

Sensitivity, specificity and predictive values of an enzyme-linked immunosorbent assay (ELISA) for detecting antibodies against bovine leukaemia virus (BLV) were evaluated using a representative sample of 145 serum pools, comprising from 3 to 48 individual sera. The sample was constituted according to the frequency distribution of the negative and positive pools analysed during a screening involving the whole cattle population of Belgium. Sensitivity and specificity were estimated to 88.9% and 100% and the predicted negative and positive values were 99.9% and 100%, respectively. These results indicate the use of serum pools is suitable for the detection of BLV infected herds in eradication campaigns. [less ▲]

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See detailSpecific DNA probes to detect Escherichia coli strains producing cytotoxic necrotising factor type 1 or type 2
Oswald, E.; Pohl, P.; Jacquemin, E. et al

in Journal of Medical Microbiology (1994), 40

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See detailConflits collectifs et recours juridictionnels
Kefer, Fabienne ULg

in Journal des Tribunaux (1994)

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See detailTests standardisés de routine pour l'évaluation de la condition physique chez les chevaux d'endurance
Noel de Burlin, A; Art, Tatiana ULg; Amory, Hélène ULg et al

in Pratique Vétérinaire Equine (1994), 26

The purpose of this study was to try to assess the fitness of endurance horses by using a simple routine standardized treadmill exercise test performed before and after a training period. Seven endurance ... [more ▼]

The purpose of this study was to try to assess the fitness of endurance horses by using a simple routine standardized treadmill exercise test performed before and after a training period. Seven endurance horses aged 7 to 13 years, unfamiliar with the treadmill conditions and competing in international championship were tested twice in an air-conditioned laboratory, i.e. before and after a 4-month training period. The test was preceded by a 20 min warm-7 period and consisted of 2 min walk and 2 min trot (4.2 m/sec) with a slope of 0, 2, 4, 6, 8 and 10 The whole test lasted 45 min. Venous blood was sampled before and 4 min after each test. Heart rate was continuously recorded before, during and after the test with a cardiometer. Rectal temperature, respiratory rate and body weight were measured before and after the test. The completion of the test induced a significant decrease of the body weight, a significant increase in packed cell volume, cortisol, white blood cells, proportion of granulocytes, lactate, free fat acids and iso-enzyme LDH 5, and no change in the ions and in the activity of the other enzymes. Training did not induce significant changes in blood parameters, except in hacked cell volume and cortisol. Training induced a significant decrease in heart rate at all exercise intensities and during recovery. It was concluded that the test proposed in this study is simple, safe, suitable for horses unfamiliar with the treadmill and applicable in a 1-day clinic routine examination. In these conditions, the most reliable parameter for the assessment of fitness in endurance horses seems to be the heart rate recorded during 2 standardized tests performed before and after a training period [less ▲]

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