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See detailBody size increase in insular rodent populations: a role for predators?
Michaux, Johan ULg; De Bellocq, J. G.; Sara, M. et al

in Global Ecology & Biogeography Letters (2002), 11(5), 427-436

Insular mammalian populations living in areas of small size are often characterized by a drastic change in body mass compared to related continental populations or species. Generally, small mammals (less ... [more ▼]

Insular mammalian populations living in areas of small size are often characterized by a drastic change in body mass compared to related continental populations or species. Generally, small mammals (less than 100 g) evolve into giant forms while large mammals (up to 100 g) evolve into dwarf forms. These changes, coupled with changes in other life, behavioural, physiological or demographic traits are referred to generally as the insular syndrome. We tested in this study the relative contribution of three factors - area of island, numbers of competitor species and number of predator species - to changes in body size of the woodmouse (Apodemus sylvaticus) in the Western Mediterranean Sea. Our results, based on a comparative analysis using the phylogenetic independent contrasts method, indicate that the increase in body size is related both to the decrease of island size and to the lower number of predator species. A decrease of competitor species does not seem to have an important effect. [less ▲]

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See detailSynthetic, structural, magnetic, and Mossbauer spectral study of {Fe[HC(3,5-Me(2)pz)(3)](2)}I-2 and its spin-state crossover behavior
Reger, D. L.; Little, C. A.; Smith, M. D. et al

in European Journal Of Inorganic Chemistry (2002), (5), 1190-1197

The complex {Fe[HC(3,5-Me(2)pz)(3)](2)}I-2 (1) has been prepared from the reaction of FeI2 and HC(3,5-Me(2)pz)(3) (pz = pyrazolyl ring) in a 1:2 ratio. The complex is high-spin in both the solid state and ... [more ▼]

The complex {Fe[HC(3,5-Me(2)pz)(3)](2)}I-2 (1) has been prepared from the reaction of FeI2 and HC(3,5-Me(2)pz)(3) (pz = pyrazolyl ring) in a 1:2 ratio. The complex is high-spin in both the solid state and in solution at ambient temperature, In the solid state, magnetic susceptibility and Mossbauer spectral studies indicate that samples of the complex that have been crystallized and dried change completely from high-spin to low-spin upon cooling below 195 K, with a substantial two-step thermal hysteresis in the transition, The spin-crossover properties of I are sample dependent: powder samples do not change to low-spin at low temperatures. Two crystalline forms of I have been identified by X-ray crystallography, one form containing no solvent of crystallization and the other containing solvent, In both, there is only one iron site, with average Fe-N bond lengths of 2.18 and 2.17 Angstrom, values that confirm that the complex is high-spin. Single crystals of the nonsolvated form shatter at low temperatures whereas single crystals of the solvated form can be cooled to 110 K with no loss of crystallinity and remain fully high spin at this temperature, Crystallographic information: nonsolvated form is triclinic, P (1) over bar, a = 8,8062(2) Angstrom, b = 10.3549(2) Angstrom, c = 11.3549(2) Angstrom, a = 104.0768(10), beta = 110.2473(10)degrees, gamma = 92.6385(11)degrees, Z = 1; solvated form is monoclinic P2(1)/c, a 10.3214(5) Angstrom, b = 12.7753(7) Angstrom, c = 20.1995(11) Angstrom, alpha = 90degrees, beta = 97.5380(10)degrees, gamma = 90degrees, Z = 2. [less ▲]

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See detailA Set Of Primers For Amplification Of Mitochondrial Dna In Picea Abies And Other Conifer Species
Jeandroz, S.; Bastien, D.; Chandelier, A. et al

in Molecular Ecology Notes (2002), 2(4),

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See detailCritères et indicateurs : les initiatives gabonaises
O'Heix, Bruno-Charles; Doucet, Jean-Louis ULg; Ondo, Rose et al

in Bois et Forêts des Tropiques (2002), 271(1), 79-88

Près de deux décennies après les premières discussions sur le concept de durabilité, le processus de mise en place de la gestion durable des forêts de production est en voie de concrétisation en zone ... [more ▼]

Près de deux décennies après les premières discussions sur le concept de durabilité, le processus de mise en place de la gestion durable des forêts de production est en voie de concrétisation en zone tropicale. Les consensus politiques et scientifiques s’ébauchent aux échelons régionaux comme nationaux. Un certain optimisme est donc de mise, même si de nombreuses questions demeurent en suspens et si les objectifs (globaux et spécifiques) demeurent encore peu lisibles. Les difficultés liées aux intérêts macro- et microéconomiques que représente la forêt sont encore renforcées par la question de la certification des bois issus de la gestion durable. Les initiatives pour la définition de normes de certification, outre leur intérêt potentiel en termes de financement de la gestion durable des forêts (GDF), ont néanmoins largement contribué à l’avancée des méthodes et des processus de développement des critères et des indicateurs (C & I) pour la mesure et le suivi de la gestion durable. De nombreux ensembles de C & I, depuis une utilisation régionale jusqu’à un usage par des unités de gestion forestière (UGF), ont vu le jour, y compris dans le bassin du Congo où aucune « gestion durable » n’a encore été validée par une certification commerciale. À ce jour, de par l’engagement du gouvernement et les initiatives précoces de certains opérateurs forestiers privés, le Gabon apparaît comme un modèle pour la région du bassin du Congo. [less ▲]

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See detailClonal diversity and metallo-beta-lactamase production in clinical isolates of Stenotrophomonas maltophilia
Mercuri, Paola ULg; Ishii, Y.; Ma, L. et al

in Microbial Drug Resistance : Mechanism, Epidemiology, & Disease (2002), 8(3), 193-200

Stenotrophomonas maltophilia is a nosocomial pathogen with an intrinsic broad-spectrum resistance to beta-lactam compounds and other antibacterial agents. It produces two chromosomal beta-lactamases: a ... [more ▼]

Stenotrophomonas maltophilia is a nosocomial pathogen with an intrinsic broad-spectrum resistance to beta-lactam compounds and other antibacterial agents. It produces two chromosomal beta-lactamases: a clavulanic acid-sensitive class A (L2) and a tetrameric carbapenemase (L1 or BlaS). We screened 40 S. maltophilia multidrug-resistant clinical isolates recovered between 1995 and 1998 in the Varese Hospital (Italy) for the presence of the metallo-beta-lactamase. The isolates were investigated by phenotypic profiling (enzymatic activity and antibiotic resistance pattern) and molecular methods such as PCR and pulsed-field gel electrophoresis (PFGE) to reveal intraspecies diversity. For the tested S. maltophilia strains, we showed that the beta-lactamase production could be induced by the presence of imipenem (50 mug/ml) in the culture media. Addition of 1 mM dipicolinic acid completely inhibited the hydrolysis of imipenem but decreased that nitrocefin in a strain-dependent manner. Full activity of crude extract towards imipenem could be restored by addition of 1 mM ZnCl2. Finally, the gene encoding the carbapenem-hydrolyzing beta-lactamase from S. maltophilia ULA-511 and 39/95, a clinical strain, were isolated and sequenced. These two strains have a different profile of multidrug resistance. The two metallo-beta-lactamases were found to be isologous. The difference of sensitivity of these two strains was associated to the level of production of the metallo-beta-lactamase. [less ▲]

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See detailIce-dynamic conditions of Shirase Glacier, Antarctica, inferred from ERS SAR interferometry
Pattyn, Frank; De Rauw, Dominique ULg

in Journal of Glaciology (2002), 48(163), 559-565

The surface velocity field of Shirase Glacier, a fast-flowing East Antarctic outlet glacier, is determined from ERS synthetic aperture radar (SAR) images by means of speckle tracking using phase ... [more ▼]

The surface velocity field of Shirase Glacier, a fast-flowing East Antarctic outlet glacier, is determined from ERS synthetic aperture radar (SAR) images by means of speckle tracking using phase correlation, a technique which matches small image kernels of two complex SAR images by maximization of the local coherence. Velocity estimates are used to calculate surface strain rates, which are then used to calculate the large-scale, vertically integrated force balance and to determine the major stress components resisting the driving stress. For the whole glacier system, the driving stress is largely balanced by the basal drag, but with contributions from lateral drag up to 15% of the driving stress at the grounding line. Longitudinal stress gradients have only local importance to the balance of forces, limited to an area of a few square kilometers near the grounding line, where they resist the driving stress. In the grounded part of the glacier, >90% of the total ice velocity is due to basal sliding. Comparison with a balance-flux distribution of the Antarctic ice sheet suggests that the glacier in the downstream part of the Shirase drainage basin is close to equilibrium, showing a slight negative imbalance. [less ▲]

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See detailLa recherche scientifique en Hautes-Fagnes
Streel, Maurice ULg

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Sciences (2002), XIII(1-6), 55-65

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See detailLe vol du cheval sacré
Swennen, Philippe ULg

in Acta Orientalia Belgica (2002), XVI

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See detailAtteintes neuromusculaires aiguës de réanimation (ANMAR) : étude électrophysiologique prospective de 56 cas
BARTSCH, Valérie ULg; TOMASELLA, Marco ULg; Zeevaert, Bernard et al

in Neurophysiologie Clinique = Clinical Neurophysiology (2002)

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See detailComment je traite.... Un pityriasis rubra pilaire.
Fraiture, A. L.; Braham, C.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(6), 363-5

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical ... [more ▼]

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical calcipotriol may improve the clinical presentation. [less ▲]

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See detailThe effect of health related quality of life on reported use of health care resources in patients with osteoarthritis and rheumatoid arthritis: a longitudinal analysis.
Ethgen, Olivier ULg; Kahler, Kristijan H; Kong, Sheldon X et al

in Journal of Rheumatology (2002), 29(6), 1147-55

OBJECTIVE: In today's cost conscious environment, health services researchers are consistently trying to find ways to predict future health care resource utilization (HCRU) and its associated costs. We ... [more ▼]

OBJECTIVE: In today's cost conscious environment, health services researchers are consistently trying to find ways to predict future health care resource utilization (HCRU) and its associated costs. We evaluated the impact of health related quality of life (HRQL) on future HCRU in patients with arthritis. METHODS: A total of 642 patients with rheumatoid arthritis (RA) and 395 patients with osteoarthritis (OA) completed at least 2 and as many as 6 consecutive surveys at 6 mo intervals. Information collected included demographics, HRQL questionnaires [Medical Outcome Study Short Form 36 (SF-36), Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), and the Stanford Health Assessment Questionnaire (HAQ)], and HCRU over the previous 6 months. Longitudinal data analysis was perfomed to assess the effect of HRQL on future HCRU. RESULTS: Statistically significant associations between HCRU and HRQL variables were noted. Higher rates of HCRU were found in those in the worst quarter compared with those in the best quarter of HRQL. With the HAQ, OA and RA patients in the worst quarter reported a 199% (p < 0.05) and 48% (p < 0.05) increase in rheumatologist visits, respectively. With the WOMAC Function, increases were as high as 196% (p < 0.05) in rheumatologist visits for patients with OA. Patients with RA with a high level of HRQL as measured by the SF-36 (physical component score) reported a decrease of 31% (p < 0.01) in general practitioner visits and a decrease of 52% (p < 0.01) in hospitalization (mental component score). CONCLUSION: These findings suggest that HRQL may be used to predict future health care consumption. Such an approach may lead to a more efficient allocation of resources by providing useful information to health care providers and health care decision makers. [less ▲]

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See detailGeochemistry of bitter brines in the Salar de Coipasa - Bolivia
Lebrun, Vincent; Pacosillo, Pedro; Gutierrez, Jorge et al

in Aardkundige Mededelingen (2002), 12

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See detailUse of multisite quantitative ultrasonography for noninvasive assessment of bone in horses
Carstanjen, B.; Lepage, O. M.; Detilleux, Johann ULg et al

in American Journal of Veterinary Research (2002), 63(10), 1464-1469

OBJECTIVE: To evaluate the usefulness of multisite quantitative ultrasonography for noninvasive assessment of bone in horses. SAMPLE POPULATION: 12 healthy horses and both forelimbs from 8 clinically ... [more ▼]

OBJECTIVE: To evaluate the usefulness of multisite quantitative ultrasonography for noninvasive assessment of bone in horses. SAMPLE POPULATION: 12 healthy horses and both forelimbs from 8 clinically normal horses. PROCEDURE: For in vivo measurements, various regions of interest (ROI) were examined on the third metacarpal bone, radius, and tibia. Precision error for speed of sound (SOS) measurements was obtained by measuring each ROI of 4 horses 10 times with probe repositioning. Additionally, 3 operators measured each aspect of the third metacarpal bone of 6 horses 5 times each. For ex vivo measurements, third metacarpal bones were examined at 9 ROI, and SOS measurements were performed before and after soft tissue removal. One ROI of a single forelimb was subjected to 96 ex vivo measurements with 3 different contact media. RESULTS: The lateral aspect of the third metacarpal bone had significantly higher SOS values than the dorsal and medial aspect of the third metacarpal bone. No difference was obtained between SOS values of the lateral and medial aspect of the radius. The tibia had significantly higher SOS values than the lateral aspect of the radius and the dorsal and medial aspect of the third metacarpal bone. Intraoperator coefficients of variation ranged from 0.62 to 3.15%, and interoperator coefficients of variation ranged from 0.78 to 2.70%. Values of SOS were highest when silicone oil was used as the contact medium. CONCLUSIONS AND CLINICAL RELEVANCE: Speed of sound measurements obtained by quantitative ultrasonography in axial transmission mode can be used to precisely measure superficial cortical bone properties of third metacarpal bone, radius, and tibia in horses. [less ▲]

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See detailBlade-Tip Timing Measurement Of Synchronous Vibrations Of Rotating Bladed
Dimitriadis, Grigorios ULg; Carrington, Ian B.; Wright, Jan Robert et al

in Mechanical Systems & Signal Processing (2002), 16(4), 599-622

Blade-tip timing (BTT) is a promising method for the detection, measurement and analysis of blade vibrations in rotating bladed assemblies. However, the intricacies of the method when applied to real ... [more ▼]

Blade-tip timing (BTT) is a promising method for the detection, measurement and analysis of blade vibrations in rotating bladed assemblies. However, the intricacies of the method when applied to real rotating structures undergoing synchronous (Engine Ordered) vibrations are not yet fully understood. In this paper, a mathematical model is developed to simulate data from typical BTT tests of rotating assemblies. The simulator is then used in order to provide a qualitative analysis of several phenomena that can be associated with the synchronous vibrations of rotating assemblies, including mistuning, coupling, excitation at multiple Engine Orders and simultaneous synchronous and asynchronous responses. It is concluded that none of these phenomena on its own will render the identification of the frequency and amplitude of blade vibrations impossible. However, there is no single BTT data analysis method that is able to deal with all of these phenomena. [less ▲]

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See detail" Entre Notre-Dame de Paris et Chartres : Le portail de Longpont-sur-Orge (vers 1235) "
Kasarska, Iliana ULg

in Bulletin Monumental (2002), 160

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See detailL'allergie aux aromes et parfums: anathème sur un attrait épicurien?
Goffin, Véronique ULg; Nikkels, Arjen ULg; Cornil, F. et al

in Revue Médicale de Liège (2002), 57(9), 605-9

Aromas and fragrances are present in many cosmetics, some topical drugs, food and various hygiene, household and industrial products. They can be responsible for contact dermatitis. Multiple ... [more ▼]

Aromas and fragrances are present in many cosmetics, some topical drugs, food and various hygiene, household and industrial products. They can be responsible for contact dermatitis. Multiple sensitizations can even involve in various combinations some fragrance compounds, a given degradation product or a contaminant. The diagnosis relies on clinical examination and oriented anamnesis. A histological examination is sometimes necessary. Specific path testing brings insight on the culprit chemical compounds. [less ▲]

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See detailExperimental Validation Of The Constant Level Method For Identification Of Non-Linear Multi-Degree-Of-Freedom Systems
Dimitriadis, Grigorios ULg

in Journal of Sound & Vibration (2002), 258(5), 829-845

System identification for non-linear dynamical systems could find use in many applications such as condition monitoring, finite element model validation and determination of stability. The effectiveness ... [more ▼]

System identification for non-linear dynamical systems could find use in many applications such as condition monitoring, finite element model validation and determination of stability. The effectiveness of existing non-linear system identification techniques is limited by various factors such as the complexity of the system under investigation and the type of non-linearities present. In this work, the constant level identification approach, which can identify multi-degree-of-freedom systems featuring any type of non-linear function, including discontinuous functions, is validated experimentally. The method is shown to identify accurately an experimental dynamical system featuring two types of stiffness non-linearity. The full equations of motion are also extracted accurately, even in the presence of a discontinuous non-linearity. [less ▲]

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See detailEtude de la perturbation de l'image du corps dans un échantillon de patientes boulimiques
Bragard, Isabelle ULg; Etienne, Anne-Marie ULg; Mayers, I. et al

in Revue Francophone de Clinique Comportementale et Cognitive (2002), 7(2), 5-18

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See detailOral antivirals revisited in the treatment of herpes zoster: what do they accomplish?
Nikkels, Arjen ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2002), 3(9), 591-8

Oral antiviral agents currently represent the most important therapeutic keystone in the treatment of herpes zoster. Three oral antiviral agents are available for the treatment of herpes zoster: acyclovir ... [more ▼]

Oral antiviral agents currently represent the most important therapeutic keystone in the treatment of herpes zoster. Three oral antiviral agents are available for the treatment of herpes zoster: acyclovir, its derivative valacyclovir, and famciclovir. Meta-analysis of published data has shown that oral acyclovir significantly reduces various herpes zoster-related symptoms as well as the duration, intensity and prevalence of zoster-associated pain (ZAP). However, this drug does not influence postherpetic neuralgia. The newer agents famciclovir and valacyclovir exhibit a better oral bioavailability than acyclovir. These agents have demonstrated similar efficacy to acyclovir with ZAP and they require less frequent administration. When initiated within 72 hours, oral antiviral therapy of herpes zoster is beneficial in selected, elderly immunocompetent patients, reducing the duration and intensity of ZAP and providing more rapid skin lesion healing. Oral antivirals are also of benefit in immunocompromised patients with uncomplicated herpes zoster. However, signs of cutaneous and visceral dissemination should be monitored; if signs occur, intravenous antiviral therapy is indicated. [less ▲]

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See detailLe médicament du mois. Le tacrolimus topique (Protopic).
Pierard, Gérald ULg; Pierard, Claudine ULg; Paquet, Philippe ULg

in Revue Médicale de Liège (2002), 57(8), 552-5

Tacrolimus is a potent inhibitor of immune mechanisms. It belongs to the macrolactam group. It inhibits the release of both Th1 and Th2 cytokines. It proves to be efficacious after topical application in ... [more ▼]

Tacrolimus is a potent inhibitor of immune mechanisms. It belongs to the macrolactam group. It inhibits the release of both Th1 and Th2 cytokines. It proves to be efficacious after topical application in the treatment of atopic dermatitis. In this indication, tacrolimus challenges topical corticosteroids. Irritation risks are present. The local immuno-depression can boost disseminated infections including herpes. The risk to promote photocarcinogenesis on the long term, and that bound to chronic resorption remain theoretical concerns that have not been assessed so far. [less ▲]

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See detailCommunication et langage chez les animaux.
Poncin, Pascal ULg; Huynen, Marie-Claude ULg; Ruwet, J.Cl.

in Bulletin de la Société Royale des Sciences de Liège (2002), 4

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See detailThe use of placebo-controlled and non-inferiority trials for the evaluation of new drugs in the treatment of postmenopausal osteoporosis
Delmas, P. D.; Calvo, Gisèle ULg; Boers, M. et al

in Osteoporosis International (2002), 13(1), 1-5

Registration of new agents for the treatment of postmenopausal osteoporosis has been based over the past few years on placebo-controlled phase III trials with the incidence of patients with new vertebral ... [more ▼]

Registration of new agents for the treatment of postmenopausal osteoporosis has been based over the past few years on placebo-controlled phase III trials with the incidence of patients with new vertebral/nonvertebral fractures as the most usual primary endpoint. The use of a placebo in diseases where an active treatment is available has been a matter of debate following the update of the Declaration of Helsinki by the World Medical Association which questioned this trial design. Current regulatory recommendations within the European Union suggest that placebo-controlled trials are still the best option when assessing the efficacy and safety of new drugs intended for the treatment of postmenopausal osteoporosis. This suggestion seems to be in apparent contradiction with the current content of the Declaration of Helsinki. This paper addresses the ethics and feasibility of placebo-controlled trials in the treatment of postmenopausal osteoporosis, in the light of available therapeutic options, and discusses possible alternative approaches in those patients where placebo treatment could be deemed to be unethical. It is concluded that placebo-controlled trials remain the most efficient design to establish the efficacy and safety of a new agent for the treatment of postmenopausal osteoporosis. Such trials are feasible and ethically acceptable in patients with osteoporosis but without prevalent vertebral fractures. Conversely, in patients with prevalent vertebral fractures, placebo-controlled trials are ethically questionable and non-inferiority trials are more appropriate. A relative margin of non inferiority of 20-30% is suggested, to be discussed on a case by case basis. [less ▲]

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See detailLe changement de sexe : perspectives pronostiques
Michel, Aude; Mormont, Christian ULg

in Neuropsy News (2002), 1(5), 224-231

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See detailCompte rendu des actes du colloque : Unanimité et diversité cisterciennes
Delfosse, Annick ULg

in Moyen Age (Le) (2002), 108(2), 380-382

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See detailEntre analyse historiciste et interdisciplinarité : Pet Sounds des Beach Boys
Pirenne, Christophe ULg

in Musurgia (2002), IX(2), 9-22

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See detailResonance-assisted tunneling
Brodier, O.; Schlagheck, Peter ULg; Ullmo, D.

in Annals of Physics (2002), 300(1), 88-136

We present evidence that tunneling processes in near-integrable systems are enhanced due to the manifestation of nonlinear resonances and their respective island chains in phase space. A semiclassical ... [more ▼]

We present evidence that tunneling processes in near-integrable systems are enhanced due to the manifestation of nonlinear resonances and their respective island chains in phase space. A semiclassical description of this "resonance-assisted" mechanism is given, which is based on a local perturbative description of the dynamics in the vicinity of the resonances. As an underlying picture, we obtain that the quantum state is coupled, via a succession of classically forbidden transitions across nonlinear resonances, to high excitations within the well, from where tunneling occurs with a rather large rate. The connection between this description and the complex classical structure of the underlying integrable dynamics is furthermore studied, giving ground to the general coherence of the description as well as guidelines for the identification of the dominant tunneling paths. The validity of this mechanism is demonstrated within the kicked Harper model, where good agreement between quantum and semiclassical (resonance-assisted) tunneling rates is found. (C) 2002 Elsevier Science (USA). [less ▲]

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See detailUn nouveau portrait social de la Wallonie
Delhausse, Bernard; Perelman, Sergio ULg; Pestieau, Pierre ULg et al

in Reflets et Perspectives de la Vie Economique (2002), XLI(3), 7-22

Au cours de l’année 1998, la pauvreté monétaire relative touche plutôt des jeunes, <br />hommes et femmes, et des femmes dans la cinquantaine. Elle atteint particulièrement <br />les individus en ... [more ▼]

Au cours de l’année 1998, la pauvreté monétaire relative touche plutôt des jeunes, <br />hommes et femmes, et des femmes dans la cinquantaine. Elle atteint particulièrement <br />les individus en difficulté sur le marché du travail et ceux qui vivent dans des <br />familles nombreuses ou monoparentales. Les étrangers, les locataires, les individus <br />qui ont fait peu d’études et les petits indépendants connaissent généralement <br />un niveau de pauvreté plus élevé que les citoyens belges, ceux qui possèdent leur <br />logement, les diplômés du secondaire ou du supérieur et les actifs salariés. Le <br />seuil de pauvreté défini pour cette étude est voisin de 5000 € de 1998 par an et <br />par personne. Selon cette définition de la pauvreté, 4,4 % de la population est <br />pauvre. [less ▲]

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See detailEffect of some insecticides on acetylcholinesterase from beneficial insects: Coccinella septempunctata, Chrysoperla carnea and Forficula auricularia
Boszic, Andras; Francis, Frédéric ULg; Gaspar, Charles et al

in Med. Fac. Landbouw. Univ. Gent (2002), 67(3), 671-677

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See detailHeat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice.
McMillan, D Randy; Christians, Elisabeth; Forster, Michael et al

in Molecular & Cellular Biology (2002), 22(22), 8005-14

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress ... [more ▼]

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the functions of HSF2 and HSF4 are less clear. Based on its developmental profile of expression, it was hypothesized that HSF2 may play an essential role in brain and heart development, spermatogenesis, and erythroid differentiation. To directly assess this hypothesis and better understand the underlying mechanisms that require HSF2, we generated Hsf2 knockout mice. Here, we report that Hsf2(-/-) mice are viable and fertile and exhibit normal life span and behavioral functions. We conclude that HSF2, most probably because its physiological roles are integrated into a redundant network of gene regulation and function, is dispensable for normal development, fertility, and postnatal psychomotor function. [less ▲]

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See detailDevelopment of a two-color picosecond optical parametric oscillator, pumped by a Nd:YAG laser mode locked using a nonlinear mirror, for doubly-resonant sum frequency generation spectroscopy
Mani, A. A.; Dreesen, Laurent ULg; Humbert, C. et al

in Surface Science (2002), 502-503

We step up a doubly-resonant sum frequency generation (DR-SFG) spectrometer based on the use of an all-solid-state flash-lamp-pumped Nd:YAG laser that synchronously pumps two parametric oscillators ... [more ▼]

We step up a doubly-resonant sum frequency generation (DR-SFG) spectrometer based on the use of an all-solid-state flash-lamp-pumped Nd:YAG laser that synchronously pumps two parametric oscillators. Pulses as short as 12 ps FWHM are generated by mode locking a Nd:YAG oscillator using a frequency doubling nonlinear mirror combined with a two-photon absorber. The available pump power is shared between a LiNbO3/AgGaS2 optical parametric oscillator (OPO), tunable from 3800 to 1100cm-1 and a BBO OPO tunable from 410 to 2600 nm. Spectral resolution and pulse are 2 and 3 cm-1 in the infrared and visible spectral ranges, respectively. First DR-SFG spectra of self-assembled monolayers on Au are presented. [less ▲]

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See detailC : N ratio increases in the phloem sap during floral transition of the long-day plants Sinapis alba and Arabidopsis thaliana
Corbesier, Laurent; Bernier, Georges ULg; Périlleux, Claire ULg

in Plant & Cell Physiology (2002), 43(6), 684-688

In plants of Sinapis alba and Arabidopsis thaliana, leaf exudate (phloem sap) was analysed during and after a single long day inducing flowering and in control short days. The amounts of carbohydrates and ... [more ▼]

In plants of Sinapis alba and Arabidopsis thaliana, leaf exudate (phloem sap) was analysed during and after a single long day inducing flowering and in control short days. The amounts of carbohydrates and amino acids were measured to estimate the organic C : N ratio. In both species, the C : N ratio of the phloem sap increased markedly and early during the inductive treatment, suggesting that an inequality in organic C and N supply to the apical meristem may be important at floral transition. [less ▲]

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See detailThe energy-conserving and energy-dissipating processes in mitochondria isolated from wild type and nonripening tomato fruits during development on the plant.
Almeida, A.; Navet, R.; Jarmuszkiewicz, W. et al

in Journal of Bioenergetics & Biomembranes (2002), 34(6), 487-498

Bioenergetics of tomato (Lycopersicon esculentum) development on the plant was followed from the early growing stage to senescence in wild type (climacteric) and nonripening mutant (nor, non-climacteric ... [more ▼]

Bioenergetics of tomato (Lycopersicon esculentum) development on the plant was followed from the early growing stage to senescence in wild type (climacteric) and nonripening mutant (nor, non-climacteric) fruits. Fruit development was expressed in terms of evolution of chlorophyll a content allowing the assessment of a continuous time-course in both cultivars. Measured parameters: the cytochrome pathway-dependent respiration, i.e., the ATP synthesis-sustained respiration (energy-conserving), the uncoupling protein (UCP) activity-sustained respiration (energy-dissipating), the alternative oxidase(AOX)-mediated respiration (energy-dissipating), as well as the protein expression of UCP and AOX, and free fatty acid content exhibited different evolution patterns in the wild type and nor mutant that can be attributed to their climacteric/nonclimacteric properties, respectively. In the wild type, the climacteric respiratory burst observed in vitro depended totally on an increse in the cytochrome pathway activity sustained by ATP synthesis, while the second respiratory rise during the ripening stage was linked to a strong increase in AOX activity accompanied by an overexpression of AOX protein. In wild type mitochondria, the 10-microM linoleic acid-stimulated UCP-activity-dependent respiration remained constant during the whole fruit development except in senescence where general respiratory decay was observed. [less ▲]

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See detailNonlinear thin shell finite element for steel and concrete structures subjected to fire: theoretical development
Talamona, Didier; Franssen, Jean-Marc ULg

in Journal of Applied Fire Science (2002), 11(4), 291-310

This article describes the features of a quadrilateral thin shell element, based on Marguerre's theory that has ben implemented in the finite element program SAFIR (from the University of Liege.) The ... [more ▼]

This article describes the features of a quadrilateral thin shell element, based on Marguerre's theory that has ben implemented in the finite element program SAFIR (from the University of Liege.) The element has four nodes (one at each corner) and each node has six degrees of freedom, i.e., three translations and three rotations (the sixth degree of freedom is a true one, which can be assimilated to the in-plane rotation.) This article presents some theoretical developments regarding the element formulation. The algorithm strategies for isotropic material (steel for example) and non-isotropic material 'concrete) and their modifications for elevated temperatures are described. Two verifications examples are presented (the patch test and Lee's frame at elevated temperatures). [less ▲]

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See detailMechanical behaviour of Lixhe chalk partly saturated by oil and water: experiment and modelling
Collin, Frédéric ULg; Cui, Yu Jun; Schroeder, Christian ULg et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2002), 26(9), 897-924

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical ... [more ▼]

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical behaviour of a chalk saturated by two non-miscible fluids, water and oil. The effects of the capillary pressure or suction are taken into account. They are considered as an independent variable, as in the Barcelona's basic model developed for unsaturated soils. On the other hand, internal friction and pore collapse are modelled as independent mechanisms. The determination of the parameters is based on triaxial and oedometer tests. Finally, in order to validate the model, predictions are compared with experimental results of water-flooding test. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailNudging acne by topical beta-lipohydroxy acid (LHA), a new comedolytic agent.
Pierard, Gérald ULg; Rougier, A.

in European Journal of Dermatology (2002), 12(4), -

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See detailL'image du mois. Sclérose tubéreuse de Bourneville.
Garcia, Roy; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(7), 425-7

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See detailReconstruction of healthcare in Afghanistan.
Porignon, Denis ULg; Hennart, Philippe

in Lancet (2002), 359(9311), 1071-2

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See detailLa mesure de la pression artérielle : écueils et chausse-trapes
Rorive, Georges ULg; Dubois, Bernard ULg; Saint-Remy, Annie ULg

in Revue Médicale de Liège (2002), 57(5), 250-252

La mesure de la pression artérielle est probablement l'acte médical le plus souvent réalisé et certainement un des moins fiables. L'introduction de la mesure ambulatoire de la pression artérielle a permis ... [more ▼]

La mesure de la pression artérielle est probablement l'acte médical le plus souvent réalisé et certainement un des moins fiables. L'introduction de la mesure ambulatoire de la pression artérielle a permis d'identifier l'importance de l'effet consultatio et, par là, de définir l'hypertension de "la blouse blanche". Celle-ci se définit comme une pression artérielle pathologique à la consultation et strictement normale en dehors. Si on la définit de cette manière, cette pathologie ne s'accompagne pas d'une augmentation de la fréqunce des affections cardiovasculaires. Chez un tiers des patients, cependant, elle évolue vers des formes plus sévères de l'hypertension. [less ▲]

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See detailLa périurbanisation résidentielle en Belgique à la lumière des contextes suisse et danois: enracinement, dynamiques centrifuges et régulations collectives
Halleux, Jean-Marie ULg; Bruck, L.; Mairy, N.

in Belgeo (2002), (4), 333-354

Par rapport à ses voisins européens, la Belgique apparaît marquée par une périurbanisation à la fois plus importante et plus éclatée, ce dont résultent sans conteste de nombreux accrochages par rapport ... [more ▼]

Par rapport à ses voisins européens, la Belgique apparaît marquée par une périurbanisation à la fois plus importante et plus éclatée, ce dont résultent sans conteste de nombreux accrochages par rapport aux principes stratégiques du développement durable. Le présent article se propose d’étudier les causes de l’éclatement urbain qui affecte le territoire belge à la lumière d’une comparaison avec la Suisse et le Danemark, deux pays réputés pour avoir mis sur pied des politiques relativement efficaces de lutte contre l’étalement urbain. De cette comparaison appréhendée via les trois thématiques de la politique foncière, de la production immobilière résidentielle et du choix clair de la Belgique en faveur de la mobilité voiture, c’est l’enracinement profond de la périurbanisation belge qui apparaît. L’éclatement urbain qui y affecte le territoire s’intègre, en effet, dans une grappe de facteurs explicatifs où s’entremêlent l’influence du milieu naturel, des réticences séculaires pour les modes de vie urbains, une faible conscientisation aux enjeux de la planification physique et des choix politiques rémanents ayant fortement contribué au renforcement des dynamiques centrifuges. [less ▲]

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See detailDéveloppement d'une ligne de transport fluvial sur le Rio Napo
Marchal, Jean ULg; Ndiaye, Alassane-Ballé ULg; JAYA, Salomon

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2002), 48

Un défi principal de la région amazonnienne de l'Equateur, qui constitue aussi un objectif politique, est de s'inscrire dans la dynamique d'un développement durable lui permettant d'éléver la qualité de ... [more ▼]

Un défi principal de la région amazonnienne de l'Equateur, qui constitue aussi un objectif politique, est de s'inscrire dans la dynamique d'un développement durable lui permettant d'éléver la qualité de vie de ses habitants et d'accéder à l'éducation, à la santé, aux emplois, de développer l'écotourisme, etc., tout en préservant la qualité de l'environnement. Cependant, cette région souffre d'un manque de transport organisé qui constitue pourtant un pré-requis indispensable à un développement durable. En effet, les seules routes existantes ne couvrent qu'une infime partie du territoire et relient uniquement les grandes villes entre elles, laissant à l'écart une grande partie de la population. Mais, la richesse de l'écosystème et la nécessité de le préserver limitent les possibilités d'extension ou de construction d'axes routiers. D'autre part, des axes tout à fait navigables existent (par exemple le rio Napo) mais leur utilisation pour le transport de personnes et de marchandises n'est ni structurée ni organisée, ce qui ne permet pas d'exploiter pleinement les opportunités offertes par le transport fluvial dans une perspective de développement durable. Le projet TransAmazone, développé par le Service ANAST (Analyse des Systèmes de Transport) de l'Université de Liège en collaboration avec le CETIF (Centre d'Excellence en Transport Intermodal et Fluvial) de l'Université Centrale d'Equateur, a pour but d'étudier la faisabilité d'un transport organisé et bien structuré utilisant les voies navigables de la région du haut Napo afin de lui permettre de relever le défi de développement durable et d'amélioration de la qualité de vie de ses habitants. [less ▲]

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See detailLes conditions d'un bien-être pour les animaux de rente.
Vandenheede, Marc ULg

in Les Elevages Belges (2002), 4

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See detailAdhesion of synchronized human hematopoietic progenitor cells to fibronectin and vascular cell adhesion molecule-1 fluctuates reversibly during cell cycle transit in ex vivo culture.
Huygen, Sandra; Giet, Olivier ULg; Artisien, Vincent et al

in Blood (2002), 100(8), 2744-52

Ex vivo expansion of hematopoietic stem/progenitor cells may result in defective engraftment. Human cord blood CD34(+) progenitor cells were synchronized and assayed for adhesion and migration onto ... [more ▼]

Ex vivo expansion of hematopoietic stem/progenitor cells may result in defective engraftment. Human cord blood CD34(+) progenitor cells were synchronized and assayed for adhesion and migration onto fibronectin (Fn) and vascular cell adhesion molecule-1 (VCAM-1) at different stages of a first cell cycle executed ex vivo. During S phase transit, adhesion to Fn was transiently increased while binding to VCAM-1 was reversibly decreased, after which adhesion to both ligands returned to baseline levels with cell cycle completion. Transmigration across Fn and VCAM-1 decreased irreversibly during S phase progression. The function of alpha4 and alpha5 integrins was assessed with specific neutralizing antibodies. In uncultured CD34(+) cells and long-term culture-initiating cells (LTC-ICs), both adhesion and migration on Fn were inhibited by anti-alpha4 but not by anti-alpha5 antibodies. In mitotically activated CD34(+) cells and LTC-ICs, adhesion and migration on Fn were mainly dependent on alpha5 integrin and to a lesser extent on alpha4 integrin. Changes in integrin function were not dependent on parallel modulation of integrin expression. In conclusion, Fn and VCAM-1 binding of progenitor cells fluctuates reversibly during cell cycle transit ex vivo. In addition, our data show that mitogenic activation induces a shift from a dominant alpha4 to a preferential alpha5 integrin-dependent interaction with Fn. [less ▲]

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See detailApplication des barycentres en logique floue
Henry, Valérie ULg

in Mathématique et Pédagogie (2002), 139

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See detailNew trends in dual 5-LOX/COX inhibition
De Leval, X.; Julémont, F.; Delarge, J. et al

in Current Medicinal Chemistry (2002), 9

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See detailEffect of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice.
Tibor, Anne; Wansard, Valerie; Bielartz, Valery et al

in Infection and Immunity (2002), 70(10), 5540-6

The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and ... [more ▼]

The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new family of outer membrane proteins specifically encountered in the family RHIZOBIACEAE: We evaluated the impact of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. The omp10 mutant was dramatically attenuated for survival in mice and was defective for growth in minimal medium but was not impaired in intracellular growth in vitro, nor does it display clear modification of the outer membrane properties. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B. abortus. [less ▲]

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See detailSynthesis of 2-amino-1,4-dihydro-4-quinolinones and diaminomethylene Meldrum’s acids derivatives as potential potassium channel openers
Erb, B.; Rigo, B.; Pirotte, Bernard ULg et al

in Journal of Heterocyclic Chemistry (2002), 39

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See detailLa conformation bouchère des agneaux. Etude d'après la variabilité génétique entre races
Laville, E.; Bouix, J.; Sayd, T. et al

in INRA Productions Animales (2002), 15(1), 53-66

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See detailApplication de Pichia anomala souche K, Beta 1,3-glucanes et chlorure de Calcium pour le contrôle des maladies de conservation des pommes en conditions proches de la pratique
Jijakli, Haissam ULg; Dickburt, C.; De Clerck, D. et al

in Colloque transnational sur les luttes biologiques, intégrée et raisonnée (2002)

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See detailEstimating effects of permanent environment, lactation stage, age, and pregnancy on test-day yield.
Bormann, J.; Wiggans, G. R.; Philpot, J. C. et al

in Journal of Dairy Science (2002), 85(1), 2631-26321

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See detailCambios en la participación política de los inmigrantes en la región de Bruselas capital. Elecciones de octubre de 2000
Martiniello, Marco ULg; Jacobs, Dirk; Rea, Andrea

in Revista Migraciones (2002), 11

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See detailExpression of the zinc finger Egr1 gene during zebrafish embryonic development
Close, Renaud; Toro, Sabrina; Martial, Joseph ULg et al

in Mechanisms of Development (2002), 118(1-2), 269-72

Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression ... [more ▼]

Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization. Egr1 mRNA is first detected in adaxial cells in the presomitic mesoderm between 11 and 20 h post-fertilization (hpf), spanning the 4-24 somite stages. Later, Egr1 expression is observed only in specific brain areas, starting at 21 hpf and subsequently increasing in distinct domains of the central nervous system, e.g. in the telencephalon, diencephalon and hypothalamus. Between 24 and 48 hpf, Egr1 is expressed in specific domains of the hypothalamus, mesencephalon, tegmentum, pharynx, retina, otic vesicle and heart. [less ▲]

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See detailApercu nosologique du spectre des histiocytoses cutanees. Plus ca change, plus c'est la meme chose.
Quatresooz, Pascale ULg; Hermanns-Lê, Trinh ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(11), 715-8

Histiocytes belong to distinct groups of cells. Similarly, histiocytoses represent some pathologic expressions of the various histiocyte lineages recognized by their distinct phenotypes. The recognition ... [more ▼]

Histiocytes belong to distinct groups of cells. Similarly, histiocytoses represent some pathologic expressions of the various histiocyte lineages recognized by their distinct phenotypes. The recognition of four major histiocytosis types relies on the distinction between monocytes-macrophages, dermal dendrocytes, Langerhans cells and the so-called indeterminate cells. Each of these groups exhibits a distinctive clinical and histological presentation. The risk of internal involvement, the prognosis and therapy are different as well. The diagnostic mainly relies on the clinico-pathologic assessment, and more particularly on the combination of histological, immunohistochemical and ultrastructural examinations. [less ▲]

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See detailCharacterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium.
Aendekerk, Severine; Ghysels, Bart ULg; Cornelis, Pierre et al

in Microbiology (Reading, England) (2002), 148(Pt 8), 2371-81

Vanadium has an antibacterial activity against Pseudomonas aeruginosa, especially under conditions of iron limitation. Some degree of resistance to V is inducible by prior exposure to the metal. One ... [more ▼]

Vanadium has an antibacterial activity against Pseudomonas aeruginosa, especially under conditions of iron limitation. Some degree of resistance to V is inducible by prior exposure to the metal. One mutant (VS1) with a higher sensitivity to V was obtained by transposon mutagenesis of P. aeruginosa PA 59.20, a clinical isolate. This mutant had an insertion in a non-coding region, upstream of a cluster of four genes. Three of them show similarities to genes corresponding to known P. aeruginosa antibiotic efflux systems, including an efflux protein, a membrane fusion protein and an outer-membrane porin. This cluster was named mexGHI-opmD. By allelic exchange, three mutants, ncr (for non-coding region), mexI and opmD were constructed in P. aeruginosa PAO1. Next to V sensitivity, the ncr, mexI and opmD mutants also showed reduced production of elastase, rhamnolipids, pyocyanine, pyoverdine and had reduced swarming motility, phenotypes that are known to be regulated by quorum sensing. All wild-type phenotypes, including growth in the presence of V, were restored by complementation with the complete cluster. The production of N-acyl-homoserine lactones (AHLs) was detected using the Chromobacter violaceum bioassay. Total extracts from the three mutants failed to induce the production of violacein by C. violaceum, although AHLs were detected by TLC and C. violaceum overlay. Violacein production was restored by complementation with mexGHI-opmD. The opmD mutant grew very slowly in LB or CAA medium, indicating that OpmD has an important physiological function for the cell. In conclusion, it is believed that the MexGHI-OpmD pump is probably involved in AHL homeostasis in P. aeruginosa. [less ▲]

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See detailResults of obesity treatment.
Scheen, André ULg

in Annales d'Endocrinologie (2002), 63(2 Pt 1), 163-70

Obesity is a chronic disease so that results of obesity treatment should only be evaluated on a long-term basis. The present paper aims at analyzing the long-term (1 year or more) results of three anti ... [more ▼]

Obesity is a chronic disease so that results of obesity treatment should only be evaluated on a long-term basis. The present paper aims at analyzing the long-term (1 year or more) results of three anti-obesity approaches, i.e. lifestyle modifications, pharmacological treatments and surgical procedures. Dietary interventions include diets with moderate calorie restriction and very-low energy diets (VLED). Even if an initial greater weight loss is observed with VLED, no study has conclusively shown that the long-term approaches including VLED are better than non-VLED programmes. Physical activity is not the most efficient method of initial weight loss, but it appears to be more crucial for maintaining weight loss once it has occurred. In general, long-term results of lifestyle modifications are disappointing because of poor compliance. Several 1-2 year large-scale randomized placebo-controlled clinical trials with orlistat, an intestinal lipase inhibitor, and sibutramine, a central appetite regulator, have demonstrated that both drugs significantly, although modestly on average, increase weight reduction, almost double the number of responders (weight loss >=5 or 10% of initial body weight) and improve weight maintenance up to 2 years. Surgical procedures provide a much greater weight reduction than medical interventions in patients with morbid obesity, particularly after a follow-up of several years. Weight loss is greater with gastric bypass, inducing some malbsorption, than with gastroplasty, a pure gastric restriction technique. Associated risk factors such as markers of insulin resistance syndrome and type 2 diabetes are remarkably reduced, but no prospective study of morbidity or mortality is available yet. In all cases, the management of obesity requires a multidisciplinary approach to improve the success rate. [less ▲]

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See detailEnquête sur les "contes" de Voltaire
Tilkin, Françoise ULg

in Cahiers Voltaire : Revue Annuelle de la Société Voltaire (2002), 1

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See detailNew 3-deoxyanthocyanidins from leaves of Arrabidaea chica
Devia, B.; Llabres, Gabriel ULg; Wouters, J. et al

in Phytochemical Analysis (2002), 13(2, Mar-Apr), 114-120

Two new 3-deoxyanthocyanidins, 6,7,3',4'-tetrahydroxy-5-methoxyflavylium and 6,7,4'-trihydroxy-5-methoxyflavylium, and the pigment carajurin, which has been previously identified, were isolated from dried ... [more ▼]

Two new 3-deoxyanthocyanidins, 6,7,3',4'-tetrahydroxy-5-methoxyflavylium and 6,7,4'-trihydroxy-5-methoxyflavylium, and the pigment carajurin, which has been previously identified, were isolated from dried leaves of Arrabidaea chica, a creeper native to the American tropics. The structures of the components were elucidated by H-1- and C-13-NMR spectroscopy and HPLC-MS, including X-ray crystallographic analysis for carajurin. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailMetapopulation dynamics of the bog fritillary butterfly: Modelling the effect of habitat fragmentation
Sawchik, J.; Dufrêne, Marc ULg; Lebrun, Philippe et al

in Acta Oecologica (2002), 23(5), 287-296

Population viability analysis (PVA) and metapopulation theory are valuable tools to model the dynamics of spatially structured populations. In this article we used a spatially realistic population dynamic ... [more ▼]

Population viability analysis (PVA) and metapopulation theory are valuable tools to model the dynamics of spatially structured populations. In this article we used a spatially realistic population dynamic model to simulate the trajectory of a Proclossiana eunomia metapopulation in a network of habitat patches located in the Belgian Ardenne. Sensitivity analysis was used to evaluate the relative influence of the different parameters on the model output. We simulated habitat loss by removing a percentage of the original habitat, proportionally in each habitat patch. Additionally, we evaluated isolation and fragmentation effects by removing and dividing habitat parches from the network, respectively. The model predicted a slow decline of the metapopulation size and occupancy. Extinction risks predicted by the model were highly sensitive to environmental stochasticity and carrying capacity. For a determined level of habitat destruction, the expected lifetime of the metapopulation was highly dependent on the spatial configuration of the landscape. Moreover, when the proportion of removed habitat is above 40% of the original habitat, the loss of whole patches invariably leads to the strongest reduction in metapopulation viability. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. [less ▲]

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See detailMore on generalized automatic sequences
Rigo, Michel ULg; Maes, Arnaud

in Journal of Automata, Languages and Combinatorics (2002), 7

We give some generalizations of $k$-automatic sequences replacing the $k$-ary system by an abstract numeration system on a regular language. We study some of the closure properties of these sequences and ... [more ▼]

We give some generalizations of $k$-automatic sequences replacing the $k$-ary system by an abstract numeration system on a regular language. We study some of the closure properties of these sequences and the possible extension to the multidimensional case or to infinite alphabets. The equivalence of these sequences and morphic predicates is given and the relationship to recognizability is also investigated. [less ▲]

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See detailRecension: "Le contrat d'entreprise. Chronique de jurisprudence (1990-2000)"
Kohl, Benoît ULg

in Actualités du Droit (2002)

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See detailEvolution pluviométrique et relation inondations – événements pluvieux au Sénégal
Sene, Souleymane; Ozer, Pierre ULg

in Bulletin de la Société Géographique de Liège (2002), 42

Since the late 1960s, Senegal suffered from the dramatic drought which affected all the Sahel of West Africa. Thirty years later, rainfall amounts well above the 1961-1990 average may announce the end of ... [more ▼]

Since the late 1960s, Senegal suffered from the dramatic drought which affected all the Sahel of West Africa. Thirty years later, rainfall amounts well above the 1961-1990 average may announce the end of this period of aridity. Together with this rainfall increase, floods have been reported in most Senegalese cities in 1999, 2000 and 2001. Because of these floods, many affected areas have been abandoned and stricken population has to be rehoused in precarious conditions. Most analysts consider these floods as a new phenomenon, never observed before, and they are blamed on the exceptional heavy daily rainfall. Analysing the relationship between floods and rainfall events in 1999 et 2000, it appears that rainfall amounts responsible for the beginning of each flood are far to be exceptional. However, the vulnerability of the Senegalese cities facing the risk of flood seems to have increased as a result of urban mismanagement. [less ▲]

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See detailL’authenticité iconographique des portails occidentaux de la cathédrale de Strasbourg
Van den Bossche, Benoît ULg

in Bulletin de la Cathédrale de Strasbourg (2002), 15

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See detailAssessment of milk yield losses and subclinical mastitis risk factors using bulk milk somatic cell counts in dairy herds
Mtaallah, Brahim; Oubey, Zied; Hammami, Hedi ULg

in Revue de Médecine Vétérinaire (2002), 153(4), 251-260

A prospective study, involving 21 selected dairy farms in north of Tunisia, was conducted to asses the loss of milk production due to high levels bulk tank somatic cell count and to find some relationship ... [more ▼]

A prospective study, involving 21 selected dairy farms in north of Tunisia, was conducted to asses the loss of milk production due to high levels bulk tank somatic cell count and to find some relationship between risk factors and subclinical mastitis. We found that the mean of bulk milk somatic cell count was 626 103 cell/ml. Using a simple statistical model, the average loss of milk due to levels bulk tank somatic cell count was 524 kg per cow per year. Using method of mean comparisons, risk factors associated to high levels bulk tank somatic cell count was: Livestock farming risk factors : inadequacy bedding area; inadequacy cleaning bedding and scrapping area. Milking risk factors : washing teat with a shower no adjustable flow and without wipe with individuel towel milk shift work above five per cow-herd; no stripping squirts of milk before milking; milking healthy and mastitis cows at the same time; no teat dipping. [less ▲]

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See detailRole of methalothionein in irradiated human rectal carcinoma.
Bouzourene, H; Chabert, P; Gebhardt, S et al

in Cancer (2002), 95(5), 1003-1008

BACKGROUND. Metallothioneins (MT) are low-molecular weight, metal-binding proteins that play a role in cellular proliferation and differentiation, as well as in cellular defense mechanisms. They act as ... [more ▼]

BACKGROUND. Metallothioneins (MT) are low-molecular weight, metal-binding proteins that play a role in cellular proliferation and differentiation, as well as in cellular defense mechanisms. They act as scavengers of free radicals produced by irradiation. A number of in vitro and in vivo studies have linked overexpression of cellular MT with tumor cell resistance to radiation. This is the first study that investigates whether MT expression is involved in the radioresistance of rectal carcinoma. METHODS. Using a mouse monoclonal antibody, MT expression was analyzed by immunohistochemistry on surgical samples (n 85) from 85 patients with locally advanced rectal carcinoma who were treated preoperatively with a hyperfractionated and accelerated radiotherapy schedule and on tumor biopsies (n 13) obtained before treatment. The potential correlations between MT expression and pathologic variables and survival were examined. RESULTS. MT were expressed strongly in both the cytoplasm and nucleus of tumor cells in 7 biopsy and 42 surgical samples. A comparison of MT expression in biopsy and surgical specimens showed that MT expression did not change after irradiation in most cases. Against all expectations, MT were expressed more frequently in tumors from responders than in those from the nonresponders (P 0.02). There was no correlation between MT expression and tumor stage, histology after radiotherapy, or survival. CONCLUSION. These findings do not support the hypothesis that MT overexpression at the end of radiotherapy is a marker for radiation resistance. Cancer 2002;95: 1003–8. © 2002 American Cancer Society. DOI 10.1002/cncr.10780 [less ▲]

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See detailAdenylate kinase 1 knockout mice have normal thiamine triphosphate levels
Makarchikov, Alexander F; Wins, Pierre; Janssen, E. et al

in Biochimica et Biophysica Acta-Molecular Cell Research (2002), 1592(2), 117-121

Thiamine triphosphate (ThTP) is found at low concentrations in most animal tissues and it may act as a phosphate donor for the phosphorylation of proteins, suggesting a potential role in cell signaling ... [more ▼]

Thiamine triphosphate (ThTP) is found at low concentrations in most animal tissues and it may act as a phosphate donor for the phosphorylation of proteins, suggesting a potential role in cell signaling. Two mechanisms have been proposed for the enzymatic synthesis of ThTP. A thiamine diphosphate (ThDP) kinase (ThDP + ATP double left right arrow ThTP + ADP) has been purified from brewer's yeast and shown to exist in rat liver. However, other data suggest that, at least in skeletal muscle, adenylate kinase I (AK1) is responsible for ThTP synthesis. In this study, we show that AK1 knockout mice have normal ThTP levels in skeletal muscle, heart, brain, liver and kidney, demonstrating that AK1 is not responsible for ThTP synthesis in those tissues. We predict that the high ThTP content of particular tissues like the Electrophorus electricus electric organ, or pig and chicken skeletal muscle is more tightly correlated with high ThDP kinase activity or low soluble ThTPase activity than with non-stringent substrate specificity and high activity of adenylate kinase. (C) 2002 Elsevier Science B.V All rights reserved. [less ▲]

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See detailAssociation of a new c-Cbl related protein with the very first stages of apoptosis induction
Corsois, L.; Quatannens, B.; Dumont, P. et al

in Cancer Detection and Prevention (2002), 26(2), 93-104

This study investigates the involvement of the c-cbl proto-oncogene during the first stages of the apoptotic process. We have already shown that a c-Cbl aptotosis-related protein of 90 kDa (CARP 90) is ... [more ▼]

This study investigates the involvement of the c-cbl proto-oncogene during the first stages of the apoptotic process. We have already shown that a c-Cbl aptotosis-related protein of 90 kDa (CARP 90) is detected very rapidly in the cytoplasm as well as in the nucleus of murine thymocytes after hydrocortisone (HC) treatment. We report here that this protein appeared as well after in vivo treatment of mice by gamma-irradiation or injection of anti-CD3 monoclonal antibody, two potent thymic apoptosis inductors, providing a close relationship between the occurrence of apoptosis and the appearance of CARP 90. We showed that CARP 90 and p120(cbl) share numerous epitopes strikingly suggesting that CARP 90 is coded by c-cbl. In addition, KO mice do not sustain CARP 90 appearance. We finally showed that CARP 90 contains N- and C-terminal end epitopes of p120(cbl) which suggests that CARP 90 is an alternative spliced form of c-cbl. This protein was also observed under gamma-irradiation in tissues of different origin, which enlarges the physiological significance of this phenomenon. The very rapid CARP 90 appearance under apoptotic conditions in the nucleus of cells originating in different tissues makes this protein if not a possible new actor of the apoptotic process, at least an interesting marker of this process. (C) 2002 International Society for Preventive Oncology. Published by Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailMass transfer by free and forced convection from single spherical liquid drops
Waheed, M Adekojo; Henschke, Martin; Pfennig, Andreas ULg

in International Journal of Heat & Mass Transfer (2002), 45(22), 4507-4514

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See detailThe role of the somatotropic axis in the mammalian metabolism
Renaville, Robert ULg; Parmentier, Isabelle; Haezebroeck, Valérie et al

in Acta Anatomica. Supplementum (2002), 5

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See detailAutonomie corporelle de la personne et responsabilité médicale
Leleu, Yves-Henri ULg; Genicot, Gilles ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002), liv. 13

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See detailPersonne morale administrateur et comité de direction
Caprasse, Olivier ULg

in Droit des Affaires : Revue Internationale du Droit des Affaires = Ondernemingsrecht : Internationaal Tijdschrift voor Ondernemingsrecht [= DA OR] (2002)

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See detailDevelopment of GEQUAC as a new group contribution method for strongly non-ideal mixtures
Ehlker, Gerhard H; Pfennig, Andreas ULg

in Fluid Phase Equilibria (2002), 203((1-2)), 53-69

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See detailInfo-congres. Prevention du diabete de type 2 chez le sujet obese: premiers resultats avec l'orlistat dans l'etude XENDOS.
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(9), 617-21

The results of the XENDOS study were presented by Professor Lars Sjostrom (Gothenburg, Sweden), on August 26, 2002, at the 9th International Congress on Obesity in Sao Paulo, Brazil. XENDOS (XENical in ... [more ▼]

The results of the XENDOS study were presented by Professor Lars Sjostrom (Gothenburg, Sweden), on August 26, 2002, at the 9th International Congress on Obesity in Sao Paulo, Brazil. XENDOS (XENical in the prevention of Diabetes in Obese Subjects) is a multicentre, randomised, double-blind, placebo-controlled, parallel-group prospective study performed in Sweden over a period of 4 years. The aim of XENDOS was to investigate the use of a weight loss agent (orlistat, Xenical) compared with lifestyle changes for the prevention of type 2 diabetes in obese patients (body mass index > or = 30 kg/m2). Weight loss was greater in the orlistat group (-6.9 kg; n = 1.640) than in the placebo group (-4.1 kg; n = 1.637; p < 0.001). Such a difference in weight reduction was sufficient to significantly reduce the cumulative incidence of type 2 diabetes (6.2% versus 9.0%; p = 0.0032; relative risk reduction of 37.3%). The difference was especially remarkable in obese patients with impaired glucose tolerance (21% of the cohort), with a reduction of conversion to diabetes from 28.8% in the placebo group to 18.8% in the orlistat group (p < 0.005) and a number needed to treat to avoid one event of 11 only. Significant and sustained reductions in cardiovascular risk factors such as arterial blood pressure and lipid levels were also observed in the orlistat group as compared to the placebo group. XENDOS is the first study demonstrating that an antiobesity agent, like orlistat, is able to reduce the progression to diabetes in obese subjects as compared with lifestyle changes alone. [less ▲]

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See detailAsymmetric dihydroxylation of C,C double bonds using catalytic amounts of osmium tetroxide, selenides, and air
Krief, A.; Colaux, Catherine ULg

in Pure & Applied Chemistry (2002), 74(1), 107-113

Selenides, selenoxides, osmium tetroxide, and potassium osmate dihydrate are in equilibrium in aqueous tert-butanol containing potassium carbonate. We took advantage of this feature to withdraw the ... [more ▼]

Selenides, selenoxides, osmium tetroxide, and potassium osmate dihydrate are in equilibrium in aqueous tert-butanol containing potassium carbonate. We took advantage of this feature to withdraw the equilibrium in each of the two directions to produce allylalcohols from allylselenides and diols from olefins. The latter reaction performed in the presence of catalytic amounts of Cinchona alkaloids and osmium tetroxide allows the enantioselective dihydroxylation of C,C double bonds. [less ▲]

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See detailEntre Italie et Pays-Bas méridionaux. Le « Libro de memoria » de la famille Cassina. 1576-1650.
Moreno, Paola ULg

in Studi e Problemi di Critica Testuale (2002)

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See detailDevelopment Of A Visual Method To Quantify The Gossypol Content In Cotton Seeds
Benbouza, H.; Lognay, Georges ULg; Palm, Rodolphe ULg et al

in Crop Science (2002), 42(6), 1937-1942

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See detailApplication of RAP-PCR and cDNA-AFLP to isolate genes of Candida oleophila (strain O) induced by the presence of galacturonic acid.
Massart, Sébastien ULg; Sens-Espel, Roser; Lepoivre, Philippe ULg et al

in Bulletin OILB/SROP = IOBC/WPRS Bulletin (2002), 25(10), 399-402

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See detailOsteoporosis in the very elderly
Halkin, V; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Medicographia (2002), 24(4), 316-321

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See detailCyclin-dependent kinase-2 controls oligodendrocyte progenitor cell cycle progression and is downregulated in adult oligodendrocyte progenitors.
Belachew, Shibeshih ULg; Aguirre, Adan A.; Wang, Hang et al

in Journal of Neuroscience (2002), 22(19), 8553-62

Proliferation of oligodendrocyte progenitor (OP) cells is a crucial process controlling myelination in the CNS. Previous studies demonstrated a correlation between OP proliferation rate and cyclin E ... [more ▼]

Proliferation of oligodendrocyte progenitor (OP) cells is a crucial process controlling myelination in the CNS. Previous studies demonstrated a correlation between OP proliferation rate and cyclin E/cyclin-dependent kinase-2 (cdk2) activity. To establish a causal link between cyclin E/cdk2 activity and OP proliferation, we selectively modulated cdk2 activity in vitro by transfection of cultured OP cells. Dominant-negative (Dn)-cdk2 overexpression inhibited mitogen-induced OP cell proliferation, whereas wild-type (wt)-cdk2 prevented cell cycle arrest caused by anti-mitotic signals. Dn-cdk2- or wt-cdk2-mediated regulation of G(1)/S transition, per se, did not influence initiation of OP differentiation. To study the function of cyclin E/cdk2 in OP cells during development in vivo, we analyzed cdk2 and cyclin E expression in cells acutely isolated from transgenic mice expressing the green fluorescent protein (GFP) under the control of the 2'-3'-cyclic nucleotide 3'-phosphodiesterase gene promoter. Both cyclin E/cdk2 protein levels and activity were decreased in GFP(+) oligodendrocyte lineage cells between postnatal days 4 and 30. Immunostaining of NG2(+)/GFP(+) OP cells in brain tissue sections showed a 90% decrease in overall cell proliferation and cdk2 expression between perinatal and adult cells. However, cdk2 expression within the proliferating (i.e., expressing the proliferating cell nuclear antigen) OP cell population was maintained throughout development. Our data indicate that: (1) cyclin E/cdk2 activity plays a pivotal function in OP cell cycle decisions occurring at G(1)/S checkpoint; (2) initiation of OP differentiation is independent of cyclinE/cdk2 checkpoint, and (3) intrinsic differences in cyclin E/cdk2 expression and activity may underlie the slowly proliferative state that characterizes so-called "quiescent" adult OP cells in vivo. [less ▲]

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See detailInfiltrative lipoma in the foreleg of a horse
Olle, Edwin; Saunders, Jimmy; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2002), 71

This case report describes an infiltrative lipoma in a horse. A slow-growing mass, detected early afterbirth, was present at the caudal aspect of the foreleg (antebrachium) of a 2-year-old gelding ... [more ▼]

This case report describes an infiltrative lipoma in a horse. A slow-growing mass, detected early afterbirth, was present at the caudal aspect of the foreleg (antebrachium) of a 2-year-old gelding. Cytological fea-tures were that of a benign lipoma. Surgical resection was attempted but failed due to the infiltrative natureof the mass. Consequently, the horse was euthanized. Histopathology revealed an infiltrative lipoma. Thistumor is histologically benign but surgical resection is usually impossible due to its infiltrative nature. [less ▲]

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See detailHartree-Fock instabilities: Relation between an artifact and some properties.
Dehareng, Dominique ULg; Dive, Georges ULg; Geron, Christine

in Recent Research Development in Chemical Physics (2002), 3

The Hartree-Fock instability problem is reviewed and some of the instabilities are put in relation with particular properties of the system.

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See detailRapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
Limbourg, Florian P; Huang, Zhihong; Plumier, Jean-Christophe ULg et al

in Journal of Clinical Investigation (2002), 110(11), 1729-38

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate ... [more ▼]

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate neuroprotection. High-dose corticosteroids (20 mg/kg intraperitoneally), given within 2 hours of transient cerebral ischemia, acutely increased endothelial nitric oxide synthase (eNOS) activity, augmented regional cerebral blood flow (CBF) by 40% to 50%, and reduced cerebral infarct size by 32%. These neuroprotective effects of corticosteroids were abolished by the GR antagonist RU486 and by inhibition of phosphatidylinositol 3-kinase (PI3K), and were absent in eNOS(-/-) mice. To determine the mechanism by which GR activated eNOS, we measured the effect of corticosteroids on PI3K and the protein kinase Akt. In a ligand-dependent manner, GR activated PI3K and Akt in vitro and in vivo caused NO-dependent vasodilation, which was blocked by cotreatment with RU486 or the PI3K inhibitor LY294002 but not by transcriptional inhibitors. Indeed, a mutant GR, which cannot dimerize and bind to DNA, still activated PI3K and Akt in response to corticosteroids. These findings indicate that non-nuclear GR rapidly activates eNOS through the PI3K/Akt pathway and suggest that this mechanism mediates the acute neuroprotective effects of corticosteroids through augmentation of CBF. [less ▲]

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See detailOver Kathrin Kötz, Die Prosa Paul van Ostaijens
Spinoy, Erik ULg

in Nachbarsprache Niederländisch (2002), 17(1-2), 122-125

This is a review of a study by Katrhin Kötz on Paul van Ostaijen's literary ('grotesque') prose and its German influences.

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See detailImaging downward granitic magma transport in the Rogaland Igneous Complex, SW norway
Bolle, Olivier ULg; Trindade, Ricardo I.F.; Bouchez, Jean-Luc et al

in Terra Nova (2002), 14(2), 87-92

Combining geological mapping and petrological, structural and geophysical (gravity and seismic) data already available for the late Proterozoic Rogaland Igneous Complex of Norway allows the 3D shape of ... [more ▼]

Combining geological mapping and petrological, structural and geophysical (gravity and seismic) data already available for the late Proterozoic Rogaland Igneous Complex of Norway allows the 3D shape of the Bjerkreim-Sokndal layered intrusion to be modelled as a thick cumulate series capped by massive granitic rocks. Using the latter data, along with the spectacular convergent linear flow pattern that covers both the cumulates and the felsic rocks of this chamber, evidence is presented to show that the granitic material was down-dragged through the sinking of its high-density mafic floor into lower density anorthosites and granulitic gneisses. This example illustrates that downward gravity-driven flows of rocks were active, in addition to upward flows, in the building of the early crust up to late-Proterozoic times, helping to explain the geochemical and structural complexities of the old crust. [less ▲]

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See detailPre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.
Baron, Frédéric ULg; Siquet, Jean; Schaaf-Lafontaine, Nicole ULg et al

in Haematologica (2002), 87(1), 78-88

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood ... [more ▼]

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood stem cell (PBSC) transplantation followed by CD8-depleted donor lymphocyte infusion (DLI). DESIGN AND METHODS: Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2 x 10(6), 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 14-24). The 1st aliquot was infused on day 60 and the other 1 (2) cryopreserved and infused on days 100 (and 140). RESULTS: An average of 100%, 100% and 84% of the scheduled dose could be administered in DLI 1, 2 and 3, respectively. Although the study group was at very high risk of GVHD, the actuarial incidence of grade II-IV acute GVHD was 28% (13% for HLA-identical siblings) with only 1 patient developing grade III-IV GVHD (after DLI). The actuarial 2-year probability of extensive chronic GVHD was similarly low (13% for all patients and 0% for HLA-identical siblings). Individual cases as well as a 30% relapse rate (0% for standard-risk patients versus 55% for high-risk patients) indicated preservation of the GVL effect. INTERPRETATION AND CONCLUSIONS: We conclude that allogeneic transplantation of CD34-selected PBSC followed by pre-emptive CD8-depleted DLI is feasible with rapid engraftment and minimizes the risk of severe GVHD. Large prospective trials are required to prove that it preserves the GVL effect fully. [less ▲]

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See detailLa traducción, otra de las plenitudes de Borges
Willson, Patricia ULg

in Variaciones Borges (2002), (14), 103-112

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See detailStimulation of collagen biosynthesis by topically applied vitamin C.
Nusgens, Betty ULg; Humbert, P.; Rougier, A. et al

in European Journal of Dermatology (2002), 12(4), -

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See detailLe mélange épicéa-douglas, une association intéressante pour le sylviculteur ? 2e partie
Colson, Vincent ULg; Claessens, Hugues ULg; Pauwels, D. et al

in Silva Belgica (2002), 109(4), 25-31

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See detailGénération d'un maillage pour éléments finis à partir de fichiers stéréolithographie (STL) : une interface indépendante des formats de CAO
Béchet, Eric ULg; Cuillière, Jean-Christophe; Trochu, François

in Revue internationale de CFAO et d'informatique graphique (2002), 17/1-2

The aim of the method proposed here is to show the possibility of generating adaptive surface meshes suitable for the finite element method, directly from an approximated boundary representation of an ... [more ▼]

The aim of the method proposed here is to show the possibility of generating adaptive surface meshes suitable for the finite element method, directly from an approximated boundary representation of an object created with CAD software. First, we describe the boundary representation, then we will show how to obtain a conforming sizeadapted mesh. The size adaptation is made considering geometrical approximation and with respect to an isotropic size map provided by an error estimator. The principle used to generate the mesh is based on the Delaunay method. Finally, we will show that not using the parametric representation of the geometrical model allows us to override some of the limitations of conventional meshing software that is based on an exact representation of the geometry. [less ▲]

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See detailAspartic proteinase members secreted by the ruminant placenta: Specificity of three radioimmunoassay systems for the measurement of pregnancy-associated glycoproteins
Perenyi, Z. S.; Szenci, O.; Drion, Pierre ULg et al

in Reproduction in Domestic Animals (2002), 37(6), 324-329

Pregnancy-associated glycoproteins (PAGs) isolated from the placenta of various ruminant species are enzymatically inactive members of the aspartic proteinase family. The measurement of these proteins in ... [more ▼]

Pregnancy-associated glycoproteins (PAGs) isolated from the placenta of various ruminant species are enzymatically inactive members of the aspartic proteinase family. The measurement of these proteins in the maternal blood can be a good indicator of the presence of a live embryo. As certain aspartic proteinases are present in biological fluids in physiological and pathological conditions at various concentrations, it was necessary to determine the specificity of three radioimmunoassay (RIA) systems currently used for the detection of PAG molecules. Commercially available members of the aspartic proteinase family like pepsinogen, pepsin, chymosin, rennet, cathepsin D and renin were tested in a wide concentration range (10 ng/ml - 1 mg/ml). Pepsinogen cross-reacted in RIA 1, RIA 2 and RIA 3 over 1 mg/ml, 50 microg/ml and 500 microg/ml concentrations, respectively. In the presence of pepsin, cross-reaction was observed in RIA 1, RIA 2 and RIA 3 over 1 mg/ml, 500 microg/ml and 1 mg/ml concentrations, respectively. Chymosin and rennet could cross-react in RIA 2 and RIA 3, while renin and cathepsin D did not decrease the binding of the tracer to antisera more, than that of the minimal detection limit. As the plasma/serum concentrations of the examined aspartic proteinases reported in the literature were outside the concentration range where cross-reaction was observed, it can be concluded that these RIA systems were specific for the detection of PAGs in biological fluids. [less ▲]

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See detailSystemic release of endotoxins induced by gentle mastication: association with periodontitis severity
Geerts, Sabine ULg; Nys, Monique; De Mol, Patrick ULg et al

in Journal of Periodontology (2002), 73(1), 73-78

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See detailCoalescence of secondary dispersions in fiber beds
Speth, Hauke; Pfennig, Andreas ULg; Chatterjee, Michael et al

in Separation and Purification Technology (2002), 29(2), 113-119

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See detailSteroid receptor coactivator SRC-1 exhibits high expression in steroid-sensitive brain areas regulating reproductive behaviors in the quail brain.
Charlier, Thierry ULg; Lakaye, Bernard ULg; Ball, Gregory F et al

in Neuroendocrinology (2002), 76(5), 297-315

The steroid receptor coactivator SRC-1 modulates ligand-dependent transactivation of several nuclear receptors, including the receptors for sex steroid hormones. Reducing the expression of SRC-1 by ... [more ▼]

The steroid receptor coactivator SRC-1 modulates ligand-dependent transactivation of several nuclear receptors, including the receptors for sex steroid hormones. Reducing the expression of SRC-1 by injection of specific antisense oligonucleotides markedly inhibits the effects of estrogens of the sexual differentiation of brain and behavior in rats and inhibits the activation of female sexual behavior in adult female rats. SRC-1 thus appears to be involved in both the development and activation of sexual behavior. In the Japanese quail brain, we amplified by RT-PCR a 3,411-bp fragment extending from the HLH domain to the activating domain-2 of the protein. The quail SRC-1 is closely related to the mammalian (m) SRC-1 and contains a high proportion of GC nucleotides (62.5%). Its amino acid sequence presents 70% identity with mammalian SRC-1 and contains the three conserved LXXLL boxes involved in the interaction with nuclear receptors. In both males and females, RT-PCR demonstrates a similarly high level of expression in the telencephalon, diencephalon, optic lobes, brain stem, spinal cord, pituitary, liver, kidney, adrenal gland, heart, lung, gonads and gonoducts. Males express significantly higher levels of SRC-1 in the preoptic area-hypothalamus than females. In both sexes, lower levels of expression are observed in the cerebellum and muscles. In situ hybridization utilizing a mixture of four digoxigenin-labeled oligonucleotides confirms at the cellular level the widespread distribution of SRC-1 mRNA in the brain and a particularly dense expression in steroid-sensitive areas that play a key role in the control of male sexual behavior. These data confirm the presence and describe for the first time the SRC-1 distribution in the brain of an avian species. They confirm its broad, nearly ubiquitous, distribution in the entire body including the brain as could be expected for a coactivator that regulates to the action of many nuclear receptors. However this distribution is heterogeneous in the brain and sexually differentiated in at least some areas. The very dense expression of SRC-1 in limbic and mesencephalic nuclei that are associated with the control of male sexual behavior is consistent with the notion that this coactivator plays a significant role in the activation of this behavior. [less ▲]

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See detailLa libre circulation des personnes dans l'Union européenne (1er janvier - 31 décembre 2001)
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2002), 10(3), 65

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See detailLe poids du Brésil dans le Mercosur: obstacle à l'intégration?
Santander, Sébastian ULg

in Cahiers du GELA-IS (2002), 2

L'article vise à analyser les implications du poids du Brésil dans la construction du régionalisme sud-américaine et en particulier du Marché commun du sud.

Detailed reference viewed: 186 (16 ULg)