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See detailPlasma Hormones and Metabolites in Cattle in Relation to Breed (Belgian Blue Vs Holstein) and Conformation (Double-Muscled Vs Dual-Purpose Type)
Clinquart, Antoine ULg; Van Eenaeme, Christian ULg; Mayombo, A. P. et al

in Veterinary Research Communications (1995), 19(3), 185-94

Four Belgian Blue double-muscled type (BBDM) bulls, four Belgian Blue dual-purpose type (BBDP) bulls and four Holstein bulls were used in a fattening trial in order to relate differences in the extent of ... [more ▼]

Four Belgian Blue double-muscled type (BBDM) bulls, four Belgian Blue dual-purpose type (BBDP) bulls and four Holstein bulls were used in a fattening trial in order to relate differences in the extent of muscle development and adiposity to differences in digestibility, endocrine status, protein and lipid metabolism. The larger muscle development in BBDM animals was associated with a trend to higher nitrogen retention, higher food conversion efficiency (p < 0.05) and lower apparent digestibility (p < 0.05). No difference was found between the groups for plasma glucose concentration. Higher creatinine, lower alpha-amino nitrogen, lower triglycerides and higher non-esterified fatty acid plasma levels were observed in BBDM as compared to Holstein bulls (p < 0.05), the BBDP group being intermediate. A trend to a higher cholesterol plasma level was found in BBDM animals. There was no difference between the three groups in plasma fatty acid composition, except for the C14:0 content. Some of the differences in plasma metabolites were related to carcass composition and endocrine regulation, a decrease in muscle development and an increase in adiposity being associated with lower growth hormone production (p < 0.05) and higher insulin (p < 0.05) and IGF secretions. The insulin/growth hormone ratio at the end of the fattening period was 0.0011, 0.0018 and 0.0069 in BBDM, BBDP and Holstein bulls, respectively, and was directly associated with fat deposition. [less ▲]

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See detailArt et pouvoir
Duchesne, Jean-Patrick ULg

in Art&fact (1995), 14

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See detailLes confraternités de l'abbaye de Stavelot-Malmedy
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1995), CLXI

réseau de fraternités de Stavelot-Malmdy mis en parallèle avec tous les échanges humains observés dans toutes les sources

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See detailDéveloppement du tissu adipeux chez le porc
Claes, Victor; Chaput, Mariella; Nicolas, Nathalie et al

in Agricontact (1995), 279

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See detailneuroendocrinology in the perinatal period
Battisti, Oreste ULg

in mini acta of belgian society of pediatrics (1995), 27

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See detailA experiência Pedagógica «Renovação do Ensino Elementar - Desenvolvimento Corporal das Crianças dos 2,5 Anos aos 12 Anos»
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Boletim Sociedade Portuguesa de Educação Física (1995), 12(2), 31-58

This paper presents the methodology and main results of a research program aiming to identify the effect of a daily physical education project implemented in the French speaking part of Belgium.

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See detail24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
Sturis, J.; Scheen, André ULg; Leproult, R. et al

in Journal of Clinical Investigation (1995), 95(4), 1464-71

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in ... [more ▼]

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine normal young men were each studied on two occasions during a 28-h period including a period of polygraphically recorded sleep. Endogenous insulin secretion was suppressed by somatostatin, a constant intravenous glucose infusion was administered, and exogenous insulin was infused either at a constant rate or in a sinusoidal pattern with a period of 120 min. The mean glucose level over the 28-h period was 0.72 +/- 0.31 mmol/liter lower when insulin was infused in an oscillatory pattern than when the rate of infusion was constant (P < 0.05). The greater hypoglycemic effect of oscillatory versus constant infusion was particularly marked during the daytime, with the difference averaging 1.04 +/- 0.38 mmol/liter (P < 0.03). Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both conditions. Ultradian insulin oscillations appear to promote more efficient glucose utilization. [less ▲]

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See detailFra Stein til Waldrop: sprogdigtningen og de nye prosadigtere
Delville, Michel ULg; Schatz-Jakobsen, Claus

in Den Blå Port: Tidsskrift for Litteratur (1995)

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See detailAnatomie chirurgicale de la valvule aortique. Relations avec le corps fibreux central et le tissu de conduction
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 286-8

L'anatomie intrinsèque de la valvule aortique est plus simple que celle des valvules auriculo-ventriculaires ; toutefois, de par sa situation anatomique centrale entre les valvules mitrale et tricuspide ... [more ▼]

L'anatomie intrinsèque de la valvule aortique est plus simple que celle des valvules auriculo-ventriculaires ; toutefois, de par sa situation anatomique centrale entre les valvules mitrale et tricuspide en arrière, les sigmoïdes pulmonaires en avant, la valvule aortique présente de multiples rapports qu'il convient de connaître. C'est l'ambition de cette revue que d'illustrer les relations de la valvule aortique avec les structures avoisinantes, de montrer la complexité de son attache à la jontion ventriculo-artérielle, et de rappeler comment sa géométrie très précise permet, en synergie avec les sinus de Valsalva, d'en optimaliser le fonctionnement hémodynamique. [less ▲]

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See detailDesign for polarizing holographic optical elements
Habraken, Serge ULg; Renotte, Yvon; Roose, Stéphane ULg et al

in Applied Optics (1995), 34(19), 3595-3602

We present results of the application of a three-dimensional rigorous-vector coupled-wave theory to the design of polarizing holographic optical elements. Two different cases have been selected giving ... [more ▼]

We present results of the application of a three-dimensional rigorous-vector coupled-wave theory to the design of polarizing holographic optical elements. Two different cases have been selected giving rise to two types of element, one of which is completely original. Experimental realizations were performed. The recording material was dichromated gelatin because of its outstanding performance related to diffraction efficiency. A fair agreement between the theoretical previsions and the experimental results was achieved. [less ▲]

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See detailLe rôle du plissement disharmonique dans la tectogenèse de l'allochtone ardennais
Mansy, J. L.; Meilliez, F.; Mercier, E. et al

in Bulletin de la Société Géologique de France (1995), 3

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See detailDecomposing efficiency into its managerial and its regulatory components: The case of European railways
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in European Journal of Operational Research (1995), 80

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See detailActivation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro.
Sheridan, P. L.; Sheline, C. T.; Cannon, K. et al

in Genes & Development (1995), 9(17), 2090-104

Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha (TCR alpha) enhancer in a context-restricted manner in T cells. In ... [more ▼]

Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha (TCR alpha) enhancer in a context-restricted manner in T cells. In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 (HIV-1) enhancer, which contains DNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by LEF-1. First, we show that mutations in the LEF-1-binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells, and that LEF-1/GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. Second, recombinant LEF-1 is shown to activate HIV-1 transcription on chromatin-assembled DNA in vitro. By using a nucleosome-assembly system derived from Drosophila embryos, we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and Ets-1) supplemented with fractions containing the promoter-binding protein, Sp1. Addition of TFE-3, which binds to an E-box motif upstream of the LEF-1 and Ets-1 sites, further augments transcription in this system. Individually or collectively, none of the three enhancer-binding proteins (LEF-1, Ets-1, and TFE-3) could activate transcription in the absence of Sp1. A truncation mutant of LEF-1 (HMG-88), which contains the HMG box but lacks the trans-activation domain, did not activate transcription from nucleosomal DNA, indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. We conclude that transcription activation by LEF-1 in vitro is a chromatin-dependent process that requires a functional trans-activation domain in addition to the HMG domain. [less ▲]

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See detailGnawing induced by dopaminergic mobilzation : differential effects of direct and indirect dopamine agonists in mice
Tirelli, Ezio ULg; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1995), 273

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See detailSurface Molecular Structure of Self-Assembled Alkanethiols Evidenced by UPS, Synchrotron Radiation and HREELS
Duwez, Anne-Sophie ULg; Riga, Joseph; ghijsen, Jacques et al

in Journal of Electron Spectroscopy & Related Phenomena (1995), 76

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See detailRegime et tactique alimentaires de la loutre (Lutra lutra) en France: synthèse.
Libois, Roland ULg

in Cahiers d'Ethologie (1995), 15(2-3-4), 251-274

More than 1500 otter spraint samples have been collected in different aquatic habitats throughout the present geographic range of the otter in France. Prey remains were identified, the relative occurrence ... [more ▼]

More than 1500 otter spraint samples have been collected in different aquatic habitats throughout the present geographic range of the otter in France. Prey remains were identified, the relative occurrence and abundance of each species was assessed and the biomass of each individual prey estimated. When available, data about the fish communities (size frequency- distributions, relative abundance) were compared with the diet of the mustelid. The main conclusions of the study are as follows: 1. The otter is mainly piscivorous but some other aquatic (crayfish) or semiaquatic preys (frogs, Natrix-snakes, some birds and mammals) are of major dietary importance in oligotrophic habitats. 2. The composition of the diet is determined by the local fish resources. The otter is an opportunistic predator, its diet varying greatly from one place to another. The diet can also change depending upon the season or upon some special circumstances such as frog or fish reproduction or strong prey-community changes. 3. Small fish are dominant in the diet. No size selection has been evidenced at least in the eel and in the cyprinid fishes. As far as the trout is concerned, it seems that the otter consumes preferably medium sized individuals. 4. The proportion of some prey species is lower in the diet than in the habitat. These are the more pelagic (bleak, sander, breams), rheophilic (dace, chub) or group-living species (minnow, roach). Bottom- (bullhead, eel, tench, gudgeon, barbel) or plant-living (rudd, pike) species are more frequent. [less ▲]

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See detailInfluence de la densité osseuse généralisée en implantologie orale
PTAK, Jean ULg; Legrand, Roman; Albert, Adelin ULg et al

in Actualités Odonto-Stomatologiques (1995), 189

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See detailRemote Sensing and Urban Change
Donnay, Jean-Paul ULg; Barnsley, Mike

in GISDATA Newsletter (1995), 6

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See detailGrowth hormone-binding protein (GHBP) binds prolactine in cattle plasma
Massart, Serge; Ban, Anna-Maria; Renaville, Robert ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995), 103

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See detailEmergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea
Bellefroid, Eric J.; Marine, Jean-Christophe; Matera, A Gregory et al

in Proceedings of the National Academy of Sciences of the United States of America (1995), 92(23), 10757-61

The ZNF91 gene family, a subset of the Kruppel-associated box (KRAB)-containing group of zinc finger genes, comprises more than 40 loci; most reside on human chromosome 19p12-p13.1. We have examined the ... [more ▼]

The ZNF91 gene family, a subset of the Kruppel-associated box (KRAB)-containing group of zinc finger genes, comprises more than 40 loci; most reside on human chromosome 19p12-p13.1. We have examined the emergence and evolutionary conservation of the ZNF91 family. ZNF91 family members were detected in all species of great apes, gibbons, Old World monkeys, and New World monkeys examined but were not found in prosimians or rodents. In each species containing the ZNF91 family, the genes were clustered at one major site, on the chromosome(s) syntenic to human chromosome 19. To identify a putative "founder" gene, > 20 murine KRAB-containing zinc finger protein (ZFP) cDNAs were randomly cloned, but none showed sequence similarity to the ZNF91 genes. These observations suggest that the ZNF91 gene cluster is a derived character specific to Anthropoidea, resulting from a duplication and amplification event some 55 million years ago in the common ancestor of simians. Although the ZNF91 gene cluster is present in all simian species, the sequences of the human ZNF91 gene that confer DNA-binding specificity were conserved only in great apes, suggesting that there is not a high selective pressure to maintain the DNA targets of these proteins during evolution. [less ▲]

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See detailGlucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies.
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1995), 19 Suppl 3

Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for ... [more ▼]

Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for insulin resistance by peripheral hyperinsulinism, the latter resulting from both increased insulin secretion and reduced insulin clearance. Impaired glucose tolerance is observed when insulin resistance is associated to impaired first-phase insulin response, which results in a significant increase in plasma glucose levels and a late insulin hyperresponsiveness. Both hyperinsulinaemia and hyperglycaemia are then able to overcome peripheral insulin resistance and impaired glucose disposal. When a more marked defect in insulin secretion is present, hyperglycaemia progresses, probably due to an additional participation of impaired suppression of hepatic glucose output. Overt diabetes then occurs with persistent post-absorptive hyperglycaemia. All these abnormalities can be reversed after a marked weight loss and recovery of ideal body weight, arguing for acquired rather than inherited metabolic defects in presence of morbid obesity. If a sufficient weight reduction can not be obtained, pharmacological approaches may be considered to improve insulin resistance of obese subjects, especially those with impaired glucose tolerance or overt diabetes. [less ▲]

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See detailBiocronoestratigrafia de miosporos do Devoniano Medio – Carbonifero inferior das bacias do Solimoes e Parnaiba (Estado da arte).
Loboziak, S; Melo, JHG; Quadros, LP et al

in Annals Academia Braziliensis Ciencas (1995), 67(3), 394-395

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See detailVaricella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency
Debrus, Serge; Sadzot-Delvaux, Catherine ULg; Nikkels, Arjen ULg et al

in Journal of Virology (1995), 69(5), 3240-3245

Varicella-zoster virus (VZV) gene 63 encodes a protein with a predicted molecular mass of 30.5 kDa which has amino acid similarities with the immediate-early (IE) protein 22 (ICP-22) of herpes simplex ... [more ▼]

Varicella-zoster virus (VZV) gene 63 encodes a protein with a predicted molecular mass of 30.5 kDa which has amino acid similarities with the immediate-early (IE) protein 22 (ICP-22) of herpes simplex virus type 1. In order to study the expression of this protein during lytic and latent infection, gene 63 was cloned in frame and downstream from the glutathione-S-transferase gene, expressed as a fusion protein, and purified. In VZV-infected Vero cells, antibodies directed against this protein detect two polypeptides of 45 and 38 kDa which are localized both in the cytoplasm and in the nucleus. Using a sequential combination of transcription and protein synthesis inhibitors (actinomycin D and cycloheximide, respectively), we demonstrated the immediate-early nature of this protein, which can thus be named IE63. Using a rat model of VZV latency, we showed that IE63 is heavily expressed, essentially in neurons, during latency. IE63 can also be detected in the skin of patients showing early herpes zoster symptoms. [less ▲]

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See detailThe Formation of National Elites de A. Kappeler (ed.)
Martiniello, Marco ULg

in Ethnic and Racial Studies (1995), 18(2), 421-422

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See detailModulation of the Clozapine Structure Increases Its Selectivity for the Dopamine D4 Receptor
Liégeois, Jean-François ULg; Bruhwyler, J.; Damas, Jacques ULg et al

in European Journal of Pharmacology (1995), 273(3), 1-3

Clozapine has a more marked affinity for the recently cloned dopamine D4 receptor than for the dopamine D2 receptor. In the search for a selective ligand for the dopamine D4 receptor, useful as a ... [more ▼]

Clozapine has a more marked affinity for the recently cloned dopamine D4 receptor than for the dopamine D2 receptor. In the search for a selective ligand for the dopamine D4 receptor, useful as a pharmacological tool or as a potent atypical antipsychotic, a pyridobenzodiazepine derivative bioisoster of clozapine, JL 18, 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido [2,3-b][1,4]benzodiazepine, was found to be the most dopamine D4-selective ligand belonging to the diarylazepine class. Indeed, JL 18 binds to the dopamine D4 receptor with affinity up to 25 times superior to that for the dopamine D2 receptor and presents reduced affinities for other receptors. [less ▲]

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See detailModulation of the Expression of Interstitial and Type-Iv Collagenases in Coculture of Ht1080 Fibrosarcoma Cells and Fibroblasts
Munaut, Carine ULg; Noël, Agnès ULg; Weidle, U. H. et al

in Invasion & Metastasis (1995), 15(5-6), 169-78

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases ... [more ▼]

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases (gelatinases A and B) in a model of coculture of human fibroblasts and HT 1080 fibrosarcoma cells. The interstitial collagenase activity, mainly found in the conditioned medium of fibroblasts, and its mRNA level were increased in the in vitro coculture model. In contrast, gelatinase A was produced by both cell types. The HT 1080 cells additionally synthesised gelatinase B. In coculture, an enhancement of gelatinase A and the presence of its activated form were observed. Northern blot analysis demonstrated that this enzymatic enhancement occurred at a pretranslational level. The stimulation of the interstitial collagenase activity was partially mediated through soluble factor(s), whereas increased gelatinase A appeared to require direct cell-cell interactions. The extracellular matrix component, type-I collagen, stimulated the enzymatic activities released by the individual cells, but it did not modulate the synthesis of interstitial collagenase in coculture. Our results demonstrate that distinct MMPs are modulated by distinct mechanisms, all depending on specific interactions between tumour cells and host fibroblasts. [less ▲]

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See detailQuantitative assessment of erythropoiesis in haemodialysis patients demonstrates gradual expansion of erythroblasts during constant treatment with recombinant human erythropoietin.
Beguin, Yves ULg; Loo, Martine; R'Zik, Samir ULg et al

in British Journal of Haematology (1995), 89(1), 17-23

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anaemia of chronic renal failure. It has been reported that reticulocytes as well as erythroid progenitors ... [more ▼]

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anaemia of chronic renal failure. It has been reported that reticulocytes as well as erythroid progenitors increase within 1-2 weeks, with no further elevation beyond this time interval. However, the erythroblast pool is quantitatively the most important compartment of erythropoiesis, and the rate, extent and duration of the expansion of erythropoietic activity in response to rHuEpo is not known. Treatment with rHuEpo was given to 64 patients i.v. thrice weekly after haemodialysis. The effect of rHuEpo was obvious from the early elevation of reticulocyte counts, but much of this increase was due to a rapid output of shift reticulocytes which levelled off after a few weeks. Serum transferrin receptor (TfR), a quantitative measure of erythropoiesis, increased progressively over 6 weeks to reach a plateau phase at about twice baseline values. The Hct increased progressively and continued to rise steadily after the TfR plateau was reached. The speed and extent of the expansion of erythropoietic activity correlated with the later haematological response to rHuEpo. When rHuEpo was discontinued, erythropoietic activity returned progressively to baseline values, to rise again gradually when treatment was resumed. Part of the Hct increase was also due to haemoconcentration. The results indicate that changes in the various erythroid compartments vary considerably in intensity and speed, and that the erythroblast compartment in particular is slow to respond to modifications in the erythropoietin stimulus. [less ▲]

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See detailGuianensine, a zwitterionic alkaloid from Strychnos guianensis
Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg; Warin, Roger et al

in Phytochemistry (1995), 40(5), 1557-1560

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new ... [more ▼]

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new alkaloid has a zwitterionic asymmetrical bis-indole structure and is named guianensine. [less ▲]

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See detailFundamentals of transformed skeletal muscle used for cardiac assistance. An overview
Radermacker, M. A.; Chachques, J. C.; Sluse, Francis ULg et al

in Research in Surgery (1995), 7

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See detailBrazilandia. Over Brazil van John Updike.
Vanden Berghe, Kristine ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(1), 112-114

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See detailCeci est mon corps
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5),

This is a special issue on the body in literature and art.

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See detailPiracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis
Peuvot, J.; Schanck, A.; Deleers, M. et al

in Biochemical Pharmacology (1995), 50(8), 1129-34

Piracetam, Nootropil (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the ... [more ▼]

Piracetam, Nootropil (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the organization of model phospholipid membranes. 31P NMR data show that the drug induces a structural modification in liposomes made of phosphatidylcholine and phosphatidylethanolamine. Our conformational analysis results have allowed the interpretation of the effect of piracetam on these model membranes: the specific interaction between the drug molecules and the phosphate headgroups induces a new organization of the lipids favouring formation of mobile drug-phospholipid complexes that exhibit an isotropic-type signal in the 31P NMR spectra. [less ▲]

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See detailEtiologie et physiopathologie du diabète de type 2.
SCHEEN, André ULg; PAQUOT, Nicolas ULg; Lefevre, P.

in Problèmes Actuels d'Endocrinologie et de Nutrition (1995), 10

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See detailTransient respiration locomotion decoupling in galloping thoroughbreds
Jolly, Sandra ULg; Art, Tatiana ULg; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1995), 18(suppl), 13-17

The compulsory respiration locomotion coupling may sometimes be broken in healthy galloping horses, leading to a `big respiratory cycle' (BRC). This work is aimed at describing the ventilatory pattern of ... [more ▼]

The compulsory respiration locomotion coupling may sometimes be broken in healthy galloping horses, leading to a `big respiratory cycle' (BRC). This work is aimed at describing the ventilatory pattern of the BRC and at studying the influence of the individual horse, gallop speed and training. Eleven healthy Thoroughbred horses were studied during a 9 week period of incremental training intensity. Instantaneous respiratory airflow, tidal volume, respiratory rate and the 02 and C02 fraction in inspired and expired gases were continuously obtained on a breath-by-breath basis during 4 standardised treadmill exercise tests (SET) performed at 3 week intervals. The inspiratory airflow of the BRC had a bi- or triphasic shape and ils inspiratory time was 1.5-fold longer than that of a normal breath. The expiratory flow was monophasic and lasted 2.5-fold longer than the normal breath. The inspiratory, but not the expiratory peak flows, remained unchanged during the BRC. The inspiratory volume was 2.0-to 1.5-fold higher than normal, according to the gallop speed. Each BRC was followed by a`readjustment cycle' (RC), which allowed the recovery of normal respiration locomotion coupling. The sum of BRC + RC times always equalled the time for 3 normal respiratory cycles. The sum of the inspiratory volumes of BRC and RC was significantly higher than the sum of their expiratory volumes. There was a highly significant effect of horse and of training on the frequency of BRC. Lastly, during the BRC and at least the 4 following respiratory cycles, the end-tidal 02 and CO, fractions were significantly lower and higher respectively. It was hypothesised that this respiratory manoeuvre could result from a negative feedback mechanism providing, at least, transiently either a readjustment of the end expiratory lung volume or an improvement of the pulmonary gas exchange [less ▲]

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See detailL'hyperthyroïdie sévère associée à la prise d'amodarone: une urgence chirurgicale
Meurisse, Michel ULg; Hamoir, Etienne ULg; Joris, Jean ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1995), 36(1), 35-45

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du ... [more ▼]

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du traitement par amiodarone, elles peuvent survenir aussi bien chez des sujets porteurs de thyroïdopathies méconnues ou négligées au moment de l'induction du traitement, que chez des patients apparemment indemnes de toute pathologie thyroïdienne pré-existante. Le traitement médical conservateur est le plus souvent inefficace. Dans ces cas, il convient de poser sans hésitation, l'indication d'une thyroïdectomie la plus radicale possible. Ce rapport traite de l'évolution post-opératoire spectaculaire et favorable de 13 cas consécutifs de thyréotoxicose sévère associée à la prise d'amiodarone. La validité de l'approche chirurgicale repose sur la correction rapide et définitive de l'état toxique après exérèse glandulaire. La morbidité quasi nulle liée au geste chirurgical est la seule alternative thérapeutique antithyroïdienne existante qui permette de poursuivre un traitement par amiodarone lorsque celui-ci est indiqué pour contrôler une arytmie menaçante [less ▲]

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See detailMapping quantitative trait loci controlling milk production by exploiting progeny testing
Georges, Michel ULg; Nielsen, D.; Mackinnon, M. et al

in Genetics (1995), 139

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny ... [more ▼]

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding. [less ▲]

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See detailEstimation de la disponibilite de la ressource forestiere. Cas d'une essence traitée en futaie équienne monospecifique.
Hebert, Jacques ULg; Laurent, Christian

in Revue Forestière Française (1995), 47(5), 572-580

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See detailApplication Of The Quasi-Static Mode Of The Drop Volume Technique To The Determination Of Fundamental Surfactant Properties
Razafindralambo, Hary ULg; Blecker, Christophe ULg; Delhaye, Sylvie et al

in Journal of Colloid and Interface Science (1995), 174(2), 373-377

The quasi-static mode of the drop volume technique has been applied for determining the equilibrium surface tension-concentration (σe-c) curves of ionic (SDS, CTAB) zwitterionic (CHAPS), and nonionic ... [more ▼]

The quasi-static mode of the drop volume technique has been applied for determining the equilibrium surface tension-concentration (σe-c) curves of ionic (SDS, CTAB) zwitterionic (CHAPS), and nonionic (Triton X-100) surfactants. The experimental values have been fitted in two parts by the best polynomial and straight-line equations. Determination coefficients (R2) higher than 0.98 were achieved for all σe-c curves. The critical micelle concentration (CMC) and surface tension at the CMC have been calculated at the intersection point of the two fitted curves. The results conform with those found in the literature. The polynomial equation derivative at the CMC was used in the Gibbs equation to calculate the maximum surface excess concentration and the corresponding molecular area. The space required per molecule under saturation conditions is in agreement with the surfactant structures. A comparison with the Wilhelmy-plate method was also made. It is concluded that the quasi-static drop volume method provides accurate results and presents many practical advantages. [less ▲]

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See detailSuivi de la saison des pluies 1991-1992 en Afrique équatoriale à l'aide des indicateurs Météosat "occurrences des nuages à sommet froid et températures de brillance maximum de surface
Kalombo, K.; Lahuec, J. P.; Erpicum, Michel ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailLes Coléoptères Carabidae (Coleoptera) de la Réserve Naturelle du Pré des Forges à Mirwart
Waeyenbergh, M.; Dufrêne, Marc ULg; Lebrun, Philippe

in Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1995), 131

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See detailVariations temporelles de la phénologie et de la composition biochimique de la phanérogame marine Posidonia oceanica en baie de Calvi
Gobert, Sylvie ULg; Belkhiria, Samy; Dauby, Patrick ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1995), 64

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See detailMolecular biology in support of an old paradigm about the induction of flowering
Périlleux, Claire ULg

in Flowering Newsletter (1995), 20

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See detailThiamine Deficiency--Induced Partial Necrosis and Mitochondrial Uncoupling in Neuroblastoma Cells Are Rapidly Reversed by Addition of Thiamine
Bettendorff, Lucien ULg; Sluse, Francis ULg; Goessens, Guy ULg et al

in Journal of Neurochemistry (1995), 65(5), 2178-2184

Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i.e., the ... [more ▼]

Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i.e., the chromatin condenses in dark patches, the oxygen consumption decreases, mitochondria are uncoupled, and their cristae are disorganized. Glutamate formed from glutamine is no longer oxidized and accumulates, suggesting that the thiamine diphosphate-dependent alpha-ketoglutarate dehydrogenase activity is impaired. When thiamine (10 microM) is added to the cells, the O2 consumption increases, respiratory control is restored, and normal cell and mitochondrial morphology is recovered within 1 h. Succinate, which is oxidized via the thiamine diphosphate-independent succinate dehydrogenase, is also able to restore a normal O2 consumption (with respiratory control) in digitonin-permeabilized thiamine-deficient cells. Our results therefore suggest that the slowing of the citric acid cycle is the main cause of the biochemical lesion induced by thiamine deficiency as observed in Wernicke's encephalopathy. [less ▲]

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See detailL'articulation des réglementations en matière de crédit hypothécaire
Biquet, Christine ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1995), Dossier n° 2

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See detailThe Dissociative Ionization of C2H2. The C+, C2+ and CH2+ Dissociation Channels. The Vinylidene Ion as a Transient?
Locht, Robert ULg; Davister, M.

in Chemical Physics (1995), 195

The dissociative electroionization of C2H2 has been investigated in the C+, C2+ and CH2+ dissociation channels. Both the translational energy and the appearance energies have been measured. The kinetic ... [more ▼]

The dissociative electroionization of C2H2 has been investigated in the C+, C2+ and CH2+ dissociation channels. Both the translational energy and the appearance energies have been measured. The kinetic energy versus appearance energy diagrams related to these species are discussed in detail and dissociation mechanisms are proposed for all observed onset energies. For the three ionic species, the dissociation pathways leading to the fragmentation of C2H2+ into C+, C2+ and CH2+ successively have to run very likely over an isomerization mechanism of the molecular ion. The isomeric vinylidene structure could be the most probable intermediate. [less ▲]

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See detailInvolvement of MMP2 and MMP9 in the development of abdominal aortic aneurysms.
SakalihasanN, Natzi ULg; DELVENNE, Philippe ULg; Nusgens, Betty ULg et al

in Cell Biology International (1995), 19(3), 250-51

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See detailPrediction Of The Antigenic Sites Of The Cystic-Fibrosis Transmembrane Conductance Regulator Protein By Molecular Modeling
Gallet, X.; Benhabiles, N.; Lewin, M. et al

in Protein Engineering (1995), 8(8), 829-34

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and ... [more ▼]

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and valuable antibodies have been raised [Muller et al. (1990) J. Gen. Virol., 71, 2709-2717]. We have improved the modelling approach to allow us to predict epitopes from the primary sequences of the cystic fibrosis transmembrane conductance regulator. The procedure involves searching for fragments of primary sequences likely to make amphipathic secondary structures, which are hydrophilic enough to be at the surface of the folded protein and thus accessible to antibodies. Amphipathic helices were predicted using the methods of Berzofsky, Eisenberg and Jahnig. Their hydrophobic-hydrophilic interface was calculated and drawn, and used to predict the orientation of the helices at the surface of the native protein. Amino acids involved in turns were selected using the algorithm of Eisenberg. Tertiary structures were calculated using 'FOLDING', a software developed by R. Brasseur for the prediction of small protein structures [Brasseur (1995) J. Mol. Graphics, in press]. We selected sequences that folded as turns with at least five protruding polar residues. One important property of antibodies is selectivity. To optimize the selectivity of the raised antibodies, each sequence was screened for similarity (FASTA) to the protein sequence from several databanks. Ubiquitous sequences were discarded. This approach led to the identification of 13 potential epitopes in the cystic fibrosis transmembrane conductance regulator: seven helices and six loops. [less ▲]

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See detailModélisation des Écoulements Hydrologiques Quasi-Tridimensionnels : Problèmes Théoriques et Numériques
Pirotton, Michel ULg

in Tribune de l'Eau (La) (1995), 48(573), 19-26

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See detailVentilatory and arterial blood gas tension adjustments to strenuous exercise in standardbreds
Art, Tatiana ULg; Lekeux, Pierre ULg

in American Journal of Veterinary Research (1995), 56(10), 1332-1337

Five healthy, fit Standardbreds (mean +/- SEM, 490.4 +/- 15.0 kg, 4.0 +/- 0.5 years) were studied during a standardized test carried out on a treadmill. The test consisted of an 8-minute warm-up and a 9 ... [more ▼]

Five healthy, fit Standardbreds (mean +/- SEM, 490.4 +/- 15.0 kg, 4.0 +/- 0.5 years) were studied during a standardized test carried out on a treadmill. The test consisted of an 8-minute warm-up and a 9-minute exercise period (1 minute at 1.7, 4, 7, 8, 9, and 10 m/s; 2 minutes at 4 m/s; and a 1-minute walk at a 6% slope). Respiratory airflow, tidal volume (V(T)), and respiratory frequency (f) were continuously recorded, using 2 ultrasonic pneumotachographs connected to a face mask and mass spectrometer. Oxygen uptake, carbon dioxide output, and expired minute volume (V(E)) were obtained on a breath by breath basis. Arterial blood was tested at the end of each step for O2 and CO2 partial pressures. Heart rate was continuously recorded, using a heart rate recording system. Stride frequency was measured at each step, and the stride frequency-to-f ratio was calculated. Venous blood was tested for plasma lactate concentration be fore and 2 minutes after completion of the test. Some horses had a locomotion-respiration coupling (LRC), but this coupling was occasional and intermittent. The f was lower and V(T) was higher than values reported for thoroughbreds working under similar experimental conditions. Nevertheless, maximal V(E) did not overshoot maximal V(E) reported in Thoroughbreds. All horses were hypoxemic and hypercapnic, but there was wide variability between subjects. The horses with the highest oxygen uptake and the lowest plasma lactate concentration were more hypoxemic and hypercapnic. The Standardbreds, studied under our laboratory conditions, did not have constant LRC and had lower f with higher V(T) than did Thoroughbreds under similar experimental conditions. Despite these differences in breathing strategy, the Standardbreds did not have higher V(E) than did Thoroughbreds, and they were hypoxemic and hypercapnic. The fact that these Standardbreds, which obviously freely selected their breathing strategy, were unable or unwilling to adopt compensatory hyperventilation reinforces the hypothesis that, in strenuous exercising horses, there could be a physiologic limit to ventilation, most probably related to mechanical factors, but independent of any LRC. [less ▲]

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See detailSU (3) scaled effective lagrangians for a hot and strange system
Jaminon, Martine ULg; Van Den Bossche, Bruno

in Nuclear Physics A (1995), 582

We construct two effective lagrangians which reproduce the explicit flavor SU(3) symmetry breaking and the trace and axial anomalies of QCD. All analytical expressions are derived for a hot strange matter ... [more ▼]

We construct two effective lagrangians which reproduce the explicit flavor SU(3) symmetry breaking and the trace and axial anomalies of QCD. All analytical expressions are derived for a hot strange matter but the results are only shown for zero baryonic density. We study the coupling of the quark condensates (u and s) to the gluon condensate. We also consider the temperature behavior of the pion and of the kaon masses. We show that the results crucially depend on the choice of the two free parameters of the model: the chiral transition can be of first or of second order; the coupling between the gluon and the quark condensates can be large or not; the meson masses can increase or decrease with temperature. The introduction of the QCD trace anomaly in the SU(3) NJL model kills the predictive character of the NJL. [less ▲]

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See detailEfficacité du piège à fosse pour la collecte d' Hypnoidus riparius (Fabricius) (Coleoptera, Elateridae)
Jeuniaux, C.; Dufrêne, Marc ULg

in Bulletin et Annales de la Société Royale Belge d’Entomologie = Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1995), 131

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See detailEvolution récente du statut de la loutre dans le Parc National des Cévennes
Fonderflick, Jocelyn; De Kermabon, Jean; Libois, Roland ULg et al

in Cahiers d'Ethologie (1995), 15(2-3-4), 233-238

In the south east of the Massif central, the Cevennes National Park covers the area along the dividing line between the Atlantic and Mediterranean catchment areas. The climatic conditions of these medium ... [more ▼]

In the south east of the Massif central, the Cevennes National Park covers the area along the dividing line between the Atlantic and Mediterranean catchment areas. The climatic conditions of these medium-sized mountains are very varied, with a high degree of seasonnality affecting the hydrologic regime of the rivers. The otter seems to have disappeared from that region around the 1960's. Some years ago, evidence was found again ona regular basis in some of these rivers. From 1990, the evolution of this otter population has been monitored by systematic observation of their signe in the principal watercourses covering an area of about 3000 km². At the same time, a preliminary study of the diet (spraint analysis) has been undertaken. Otter signs have been first evidenced on the upper reaches of the rivers Tarn and Lot. In subsequent years, signs have been disovered on some tributaries and on a watercourse flowing to the Mediterranean side: the river Luech. In the river Tarn (upper barbel zone), the most frequent prey is the gudgeon, reaching more than 50% of the total number of prey. However, when the biomass intake is considered, the barbel appears to play the major role, accounting for 46 % of the total food intake. The occurrence of the brown trout (11 %) and its relative biomass (18 %) are weak when compared with the composition of the river fish fauna (25 to 43 % of the estimated fish biomass). [less ▲]

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See detailNotice sur Marcel Migeotte
Biémont, Emile ULg

in Annuaire de l'Académie Royale de Belgique (1995)

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See detailReactivity and Collisionally Activated Dichlorocarbene Dications studied by Tandem Mass Spectrometry.
Leyh, Bernard ULg; Hautot, D.

in Journal of the American Society for Mass Spectrometry (1995), 6

The dissociation mechanisms of dichlorocarbene dications following collisional activation have been investigated via tandem mass spectrometric technique and semi-empirical calculations. Three channels ... [more ▼]

The dissociation mechanisms of dichlorocarbene dications following collisional activation have been investigated via tandem mass spectrometric technique and semi-empirical calculations. Three channels appear to be significant: (CCl2)2+->CCl+(X1Sigma+)+Cl+(3P) (channel 1); (CCl2)2+->CCl+(X1Sigma+)+Cl+(1D) (channel 2); (CCl2)2+->(Cl2)+(X2Pig)+C+(2P). The second channel becomes dominant at high internal energy. Production of ground state fragments (channel 1) involves a transition driven by spin-orbit coupling from the (CCl2)2+ X 1Sigma+g state to the (CCl2)2+ a 3Sigma-u state en route to the fragments. The dissociation barrier for the production of the ground state fragments from the ground electronic state of (CCl2)2+ via the spin-orbit-induced transition is equal to 420 kJ/mol. The dissociation pathway that corresponds to channel 3 includes a first isomerization step from the linear (Cl-C-Cl)2+ structure to a bent (Cl-C-Cl)2+ connectivity. The calculated isomerization barrier amounts to 550 kJ/mol. The calculated reverse activation barriers are compatible with the measured kinetic energy released on the fragments. [less ▲]

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See detailJ. Peneff : l'hôpital en urgence
Melard, François ULg

in Recherches sociologiques (1995), 1

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See detailPulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1995), 42(8), 531-544

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in ... [more ▼]

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies. [less ▲]

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See detailAvoided resonance overlapping beyond the energy independent formalism. I. Vibrational predissociation
Desouter, Michèle ULg; Liévin, Jacques; Brems, Vincent

in Journal of Chemical Physics (1995), 103

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See detailPhysiologie et physiopathologie du facteur d'activation plaquettaire et perspectives thérapeutiques de ses antagonistes
Van de Weerdt, ML; Desmecht, Daniel ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1995), 139

Le facteur d'activation plaquettaire (PAF) est un phospholipide dérivé de l'acide arachidonique dont la particularité est d'activer l'agrégation et la dégranulation des plaquettes. Le PAF est également un ... [more ▼]

Le facteur d'activation plaquettaire (PAF) est un phospholipide dérivé de l'acide arachidonique dont la particularité est d'activer l'agrégation et la dégranulation des plaquettes. Le PAF est également un puissant médiateur de l'inflammation sécrété par de multiples cellules. Il est capable de moduler et d'amplifier la cascade de l'inflammation. Ce travail de synthèse expose dans sa première partie, le processus de biosynthèse du PAF ainsi que le rôle qu'il joue dans le rétrocontrôle ou l'amplification de la cascade de l'inflammation. Dans la seconde partie, l'accent est mis sur la physiopathologie du PAF et cela plus particulièrement pour les systèmes respiratoire et cardiovasculaire. Enfin, les antagonistes du PAF les plus couramment utilisés sont repris dans un tableau où figurent l'espèce étudiée ainsi que les améliorations cliniques obtenues. [less ▲]

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See detailSecond-generation octarellins: two new de novo (beta/alpha)8 polypeptides designed for investigating the influence of beta-residue packing on the alpha/beta-barrel structure stability
Houbrechts, Annick ULg; Moreau, Benoît; Abagyan, Ruben et al

in Protein Engineering (1995), 8(3), 249-59

The sequence of octarellin I, the first de novo (beta/alpha)8 polypeptide, was revised according to several criteria, among others the symmetry of the sequence, beta-residue volume and hydrophobicity, and ... [more ▼]

The sequence of octarellin I, the first de novo (beta/alpha)8 polypeptide, was revised according to several criteria, among others the symmetry of the sequence, beta-residue volume and hydrophobicity, and charge distribution. These considerations and the overall conclusions drawn from the first design led to two new sequences, corresponding to octarellins II and III. Octarellin II retains perfect 8-fold symmetry. Octarellin III has the same sequence as octarellin II, except for the beta-strands which exhibit a 4-fold symmetry. The two proteins were produced in Escherichia coli. Infrared and CD spectral analyses of octarellins II and III reveal a high secondary structure content. Non-denaturing gel electrophoresis, molecular sieve chromatography and analytical ultracentrifugation suggest that both of these second-generation artificial polypeptides exist as a mixture of a monomer and a dimer form. Octarellins II and III are at least 10 times more soluble than octarellin I. Urea-induced unfolding followed by fluorescence emission suggests that the tryptophan residues, designed to be buried in the (beta/alpha)8, are indeed packed in the hydrophobic core of both proteins. However, octarellin III displays a higher stability towards urea denaturation, indicating that introducing 4-fold symmetry into the beta-barrel might be important for stability of the overall folding. [less ▲]

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See detailBORN EFFECTIVE CHARGES OF BARIUM-TITANATE - BAND-BY-BAND DECOMPOSITION AND SENSITIVITY TO STRUCTURAL FEATURES
Ghosez, Philippe ULg; GONZE, X.; LAMBIN, P. et al

in Physical Review. B : Condensed Matter (1995), 51(10), 6765-6768

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See detailRat embryo fibroblasts immortalization by bovine leukemia virus Tax protein
Willems, Luc ULg; Heremans, H.; Burny, A. et al

in Methods in Cell Science : An Official Journal of the Society for in Vitro Biology (1995)

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See detailCharacterization of monoclonal antibodies against stromelysin-3 and their use to evaluate stromelysin-3 levels in breast carcinoma by semi-quantitative immunohistochemistry
Santavicca, M.; Noël, Agnès ULg; Chenard, M. P. et al

in International Journal of Cancer = Journal International du Cancer (1995), 64(5), 336-341

Stromelysin-3 (ST3) is a matrix metalloproteinase which is expressed in fibroblastic cells of most human invasive carcinomas and represents a potential new prognostic indicator. Expression of recombinant ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase which is expressed in fibroblastic cells of most human invasive carcinomas and represents a potential new prognostic indicator. Expression of recombinant ST3 forms in Escherichia coli from cDNA constructs indicated that high levels of expression were achieved when the ST3 pro-domain was deleted. The putative mature form of ST3 thus produced and recovered from bacterial inclusion bodies was used to prepare monoclonal antibodies (MAbs) against ST3 by immunization of BALB/C mice. Ten hybridomas producing MAbs against ST3 were obtained and analyzed for their ability to detect endogenous ST3 in breast cancer and in conditioned media from human fibroblasts. One of these MAbs (5ST-4A9) was found to be suitable for the routine detection of ST3 on breast cancer tissue sections, thus opening the possibility to evaluate ST3 prognostic value in breast cancer using semi-quantitative immunohistochemistry [less ▲]

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See detailThe Dissociative Electroionization of Carbon Dioxide by low-energy Electron Impact. The C+, O+ and CO+ Dissociation channels.
Locht, Robert ULg; Davister, M.

in International Journal of Mass Spectrometry and Ion Processes (1995), 144

This work reports the dissociative ionization of CO2 between 19-40 eV. The three dissociation channels producing C+, O+ and CO+ are examined in detail. Translational energy distributions as a function of ... [more ▼]

This work reports the dissociative ionization of CO2 between 19-40 eV. The three dissociation channels producing C+, O+ and CO+ are examined in detail. Translational energy distributions as a function of the impinging electron energy and the ionization efficiency for fixed kinetic energy carried away by the fragments are measured. The kinetic energy versus appearance energy diagram is obtained for the three fragment ions. When available, the present results are compared with previous measurements. The lowest appearance energy of O+ and CO+ corresponds to the predissociation of the CO2+ (C2Sigma +/g) state. At higher energies all the fragment ions are exclusively produced by the dissociative ionization of CO2 in the multiple electron transition (MET) states. Predissociation is most probably the dominant mechanism. Each MET state branches off to produce not only the three fragments but also the same fragment in two different states. This is observed for each dissociation channel, i.e. O+, CO+ and/or C+. In the latter channel no evidence is found for the dissociative ionization reaction CO2+->C++2O. [less ▲]

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See detailEnergy levels of High l - States in Neutral and Singly Ionized Argon
Palmeri, P.; Biémont, Emile ULg

in Physica Scripta (1995), 51

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See detailLa fin du Mésolithique et le Néolithique au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailNucleotide sequence of the bovine P53 tumor-suppressor cDNA.
Dequiedt, Franck ULg; Willems, Luc ULg; Burny, A. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1995), 5(4),

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See detailDetection of Ground Movements on the Mt. Etna Volcano using the Global Positioning System
Bruyninx, Carine; Warnant, René ULg

in Acta Vulcanologica (1995), 7(1), 27-33

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See detailMonoclonal antibodies against bovine growth hormone (bGH) enhance the biological response to GH by prolonging GH binding to its liver receptors.
Beauloye, V.; Muaku, S. M.; Portetelle, Daniel ULg et al

in Endocrinology (1995), 136(Suppl 1), 344

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See detailThe appearance energy of C2H+ from C2H2 revisited. A Photoion-Photoelectron Coincidence Spectroscopic Determination.
Servais, Christian ULg; Locht, Robert ULg

in Chemical Physics Letters (1995), 236

The dissociative ionization of C2H2 in the C2H+-producing channel has been reconsidered. The photoion-photoelectron coincidence (PIPECO) technique has been used. The C2H+/e coincidence rate has been ... [more ▼]

The dissociative ionization of C2H2 in the C2H+-producing channel has been reconsidered. The photoion-photoelectron coincidence (PIPECO) technique has been used. The C2H+/e coincidence rate has been recorded between 16.2 and 21.2 eV. The lowest appearance energy determined for C2H+ is 17.35+/-0.04 eV. A second appearance energy is measured at 18.40+/-0.04 eV. At both energies ethynyl ions are produced through a predissociation mechanism at the expense of the C2H2+(A2Ag) state at 17.35 eV and C2H2+(B2Sigma+/g) at 18.40 eV. These results are in good agreement with the most recent TPIPECO experiments and dissociative electroionization results. This comparison leads to the exclusion of any contribution of autoionization phenomena to the C2H+ ion production between 16.2 and 21.2 eV. Investigations of C2H+ through the ion-pair formation channel (and dissociative electron attachment producing C2H- and H-) in C2H2 are reported and its contribution to C2H+ ion production below 17.3 eV must be discarded. [less ▲]

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See detailExtraction d'une canine chez un ours polaire
DUFOUR, Pascale ULg; Balligand, Marc ULg; Pypendop, B. et al

in Annales de Médecine Vétérinaire (1995)

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See detailContribution de la chimie macromoléculaire à l'élaboration de matériaux colloïdaux et microparticulaires destinés à la vectorisation de médicaments
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Innovation et Technologies en Biologie et en Médecine (1995), 16

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological ... [more ▼]

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological target. The aim of the paper is to give some insight about the contribution of the macromolecular engineering for the development of two vectors : microparticles of a control biodegradation rate designed for the chemoembolization of hepatocarcinoma , amphiphile copolymeric micelles able to transport drug within the targeted cells. Starting from a synthetic polymer : polylactide, degradation rate caracteristics , and functionalities can be tailored for the intended applications. One of the major problems , and largely underestimated in the past , for the successfull design of polymeric carrier is to take into account the interaction of proteins with polymer surfaces. [less ▲]

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See detailScreening for in vitro Antifungal Activities of some Indole Alkaloids
Quetin-Leclercq, J.; Favel, A.; Balansard, G. et al

in Planta Medica (1995), 61

Thirty indole alkaloids were tested by the agar dilution technique on a panel of human pathogenic fungi, yeasts and dermatophytes. Our results indicate that the most active compounds possess a beta ... [more ▼]

Thirty indole alkaloids were tested by the agar dilution technique on a panel of human pathogenic fungi, yeasts and dermatophytes. Our results indicate that the most active compounds possess a beta-carboline skeleton and that the presence of a 3,4 double bond enhances the activity. Our results also show that antifungal activities are not linked to the cytotoxic, antimicrobial or antiparsitic properties. [less ▲]

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See detailNF-kappaB transcription factor and human immunodeficiency virus type 1 (HIV-1) are activated by methylene blue photosensitization
Piret, Bernard; Legrand-Poels, Sylvie ULg; Sappey, Christine et al

in European Journal of Biochemistry (1995)

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See detailIsolated Atherosclerotic Aneurysms of the Iliac Arteries
Desiron, Quentin ULg; Detry, Olivier ULg; Sakalihasan, Natzi ULg et al

in Annals of Vascular Surgery (1995), 9(Suppl), 62-6

Atherosclerotic aneurysms limited to the iliac arteries are rare and entail a high risk of rupture. To evaluate the efficacy of prophylactic surgery, we retrospectively studied 15 patients (13 men and two ... [more ▼]

Atherosclerotic aneurysms limited to the iliac arteries are rare and entail a high risk of rupture. To evaluate the efficacy of prophylactic surgery, we retrospectively studied 15 patients (13 men and two women; mean age 69 years) treated for isolated iliac aneurysms in the Department of Cardiovascular Surgery at the University Hospital of Liege over a period of 18 years. They had a total of 25 aneurysms (20 common iliac and five internal iliac). Six patients were treated electively and nine on an emergency basis for rupture. Five of the emergency patients (33%) died in the early postoperative period (< 30 days); in each case the aneurysm had ruptured and an emergency operation was performed (55.5% mortality in the ruptured iliac aneurysm group). On the other hand, all patients treated electively survived. Our study is comparable to other recent series in the literature, which also reported a high incidence of rupture and death in emergency operations. Prophylactic elective surgery is recommended for iliac aneurysms. [less ▲]

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See detailPerformance of Belgian hospitals: a frontier approach
Fecher-Bourgeois, Fabienne ULg; Bosmans, Nathalie

in Health Economics (1995), 4,5(Sep-oct 1995), 389-397

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See detailAnalysis of learning tasks proposed within a volleyball teaching unit in secondary education. Comparison between two teachers differentiated by their expertise
Cloes, Marc ULg; Lapierre, Annick; Piéron, Maurice

in International VolleyTech (1995), 4

School physical education focussed on the harmonious development of the individual's various components - namely his motor, cognitive, affective and social dimensions. Within the French-speaking Community ... [more ▼]

School physical education focussed on the harmonious development of the individual's various components - namely his motor, cognitive, affective and social dimensions. Within the French-speaking Community of Belgium, as in many other regions in the world, the practive of voleyball comes within the activities proposed in the physical education programme of secondary education. The analysis of activites put forward by physical education teachers shows that volayball is the most practised collective sport in secondary education... [less ▲]

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See detailProposition Of A 3-Dimensional Representation Of The Constitutive Protein Of The Hepatitis-B Surface-Antigen Particles
Sonveaux, N.; Ruysschaert, Jm.; Brasseur, Robert ULg

in Journal of Protein Chemistry (1995), 14(6), 477-86

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle ... [more ▼]

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle membrane could provide helpful information for replacing surface-exposed protein domains by foreign sequences without destabilizing the particle structure. Since the crystallization of the protein in its lipid environment remains inaccessible in the near future, alternative approaches had to be envisaged. We combine here the available experimental structural and topological data with a conformational procedure to identify membrane-associated domains of the HBsAg protein and to propose a three-dimensional description of their assembly within the particle membrane. The proposed protein structure is composed of four membrane-spanning helices and an amphipatic helix located on the inner surface membrane. The transmembrane helices are assembled into a highly hydrophobic complex in which no access to the water environment is allowed. The approach could be extended to other membrane-associated proteins. [less ▲]

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See detailHemodynamic effects of intratracheal administration of Pasteurella haemolytica in calves
Amory, Hélène ULg; Linden, Annick ULg; Desmecht, Daniel ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailUse of a model to understand prolactin and growth hormone specificities
Goffin, Vincent; Martial, Joseph ULg; Summers, Neena L.

in Protein Engineering (1995), 8(12), 1215-31

A human prolactin (hPRL) model based on a 2.1 A resolution X-ray refinement of porcine growth hormone is reported. Only regions clearly defined in the growth hormone template (the four-helix bundle) or ... [more ▼]

A human prolactin (hPRL) model based on a 2.1 A resolution X-ray refinement of porcine growth hormone is reported. Only regions clearly defined in the growth hormone template (the four-helix bundle) or previously assumed to be involved in hPRL-receptor binding (the bundle and the binding site loop) are included. A description of the model construction is provided and the resulting hPRL structure is used to interpret mutation/activity data for the cross-reactivity of human growth hormone (hGH) with the lactogenic receptor and the binding of human and bovine prolactin to the lactogenic receptor. The recognition of hPRL by its receptor unexpectedly appears to resemble more closely the interaction of hGH with the somatogenic receptor than with the lactogenic receptor. Each hGH binds to two receptor molecules, and an essential second messenger mediated by correct formation of the receptor-receptor interface has been proposed. The absence of receptor cross-reactivity for hPRL is linked to key sequence changes in hPRL which could disrupt hPRL-somatogenic receptor binding at the second site. A number of previous experiments have relied on the assumption that bioactivity is mediated by homologous residues at topologically equivalent positions. According to the model, this does not appear to be strictly true at either binding site. Good correlation at equivalent positions may be restricted to residues that are important for maintaining binding site shape as well as providing complementary stabilizing interactions between the hormone and receptor. Experiments are proposed to test our hypotheses. [less ▲]

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See detailSerotonin 5HT2 receptor imaging in the human brain using positron emission tomography and a new radioligand, [18F]altanserin: results in young normal controls.
Sadzot, Bernard ULg; Lemaire, Christian ULg; Maquet, Pierre ULg et al

in Journal of Cerebral Blood Flow & Metabolism (1995), 15(5), 787-97

Changes in serotonin-2 receptors have been demonstrated in brain autopsy material from patients with various neurodegenerative and affective disorders. It would be desirable to locate a ligand for the ... [more ▼]

Changes in serotonin-2 receptors have been demonstrated in brain autopsy material from patients with various neurodegenerative and affective disorders. It would be desirable to locate a ligand for the study of these receptors in vivo with positron emission tomography (PET). Altanserin is a 4-benzoylpiperidine derivative with a high affinity and selectivity for S2 receptors in vitro. Dynamic PET studies were carried out in nine normal volunteers with high-specific activity (376-1,680 mCi/mumol) [18F]altanserin. Arterial blood samples were obtained and the plasma time-activity curves were corrected for the presence of labeled metabolites. Thirty minutes after injection, selective retention of the radioligand was observed in cortical areas, while the cerebellum, caudate, and thalamus had low radioactivity levels. Specific binding reached a plateau between 30 and 65 min postinjection at 1.8% of the injected dose/L of brain and then decreased, indicating the reversibility of the binding. The total/nonspecific binding ratio reached 2.6 for times between 50 and 70 min postinjection. The graphical analysis proposed by Logan et al. allowed us to estimate the binding potential (Bmax/KD). Pretreatment with ketanserin was given to three volunteers and brain activity remained uniformly low. An additional study in one volunteer showed that [18F]altanserin can be displaced from the receptors by large doses of ketanserin. At the end of the study, unchanged altanserin was 57% of the total plasma activity. These results suggest that [18F]altanserin is selective for S2 receptors in vivo as it is in vitro. They indicate that [18F]altanserin is suitable for imaging and quantifying S2 receptors with PET in humans. [less ▲]

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See detailExpression of the monomeric 67-kd laminin-binding protein in human lymphomas as defined by MLuC5 monoclonal antibody and paraffin section immunohistochemistry.
Carbone, A.; Gloghini, A.; Colombatti, A. et al

in Human Pathology (1995), 26(5), 541-6

Interactions between cancer cells and laminin, a major component of basement membranes, are mediated through a large variety of cell surface proteins designated as laminin receptors. Among the above ... [more ▼]

Interactions between cancer cells and laminin, a major component of basement membranes, are mediated through a large variety of cell surface proteins designated as laminin receptors. Among the above proteins, a 67-kd monomeric high affinity laminin receptor (67 LR) has long been suspected to be involved in tumor progression. In this study we wished to establish whether the 67 LR molecule is detectable on tumor cells of Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NHLs), to define its pattern of expression, and to assess the potential utility of 67 LR in differentiating these pathological entities. Morphological and immunohistological studies were performed on 85 specimens of HD and a series of 334 NHL specimens, including anaplastic large cell (ALC) (CD30-positive) lymphomas (73 specimens). For immunohistochemical assessment of the 67 LR we used the monoclonal antibody (MoAb) MLuC5 directed against the 67-kd laminin receptor on paraffin-embedded sections. Reed-Sternberg cells reacted with MLuC5 MoAb in four of 85 (4.7%) HD specimens. Among the NHL specimens, a MLuC5-positive reaction was expressed in 3.3% of B-cell lymphomas. They all belonged to the high grade subtypes. On the other hand, a MLuC5-positive reaction was detected in none of the T-cell lymphomas tested. In contrast to the results obtained with the other NHLs, in 30.2% of ALC (CD30-positive) lymphoma specimens, tumor cells reacted with MLuC5 MoAb. MLuC5-expressing ALC (CD30-positive) lymphoma cells were of either T-cell (six of 17 specimens), B-cell (three of 25 specimens), or undetermined phenotype (10 of 31 specimens). Our investigation has shown that 67 LR as shown by MLuC5 MoAb is detectable only in neoplastic cells of a fraction of ALC (CD30-positive) lymphomas and small subsets of B-cell high grade NHLs and HD. The restricted expression of the 67 LR molecule to ALC (CD30-positive) lymphomas provides a potential tool for the phenotypic separation of this pathological entity from HD and other lymphomas. Whether the detection of the 67 LR expression in these lymphoma subsets may be related to the aggressiveness of the disease remains to be ascertained. [less ▲]

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See detailEffects of an enriched environment on subsequent fear reactions of lambs and their mothers.
Vandenheede, Marc ULg; Bouissou, Marie-France

in Applied Animal Behaviour Science (1995), 44

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See detailFollicular Dendritic Cells: Origin and Function
Heinen, Ernst ULg; Bosseloir, A.; Bouzahzah, F.

in Current Topics in Microbiology and Immunology (1995), 201

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See detailSurgical Technique for Reinforcement Cardiomyoplasty
RADERMECKER, Marc ULg; Chachques, J.C.; Fourny, J. et al

in Acta Chirurgica Belgica (1995), 95(6), 271-4

The current technique for reinforcement cardiomyoplasty in man is detailed. The authors emphasize the critical points that determine the perfect execution of this operation. This innovative surgical ... [more ▼]

The current technique for reinforcement cardiomyoplasty in man is detailed. The authors emphasize the critical points that determine the perfect execution of this operation. This innovative surgical approach to heart failure is continuously evolving and, therefore, may be subject to improvement. The major principles however remain valuable. [less ▲]

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See detailLumière und der Augen-Blick
Belloi, Livio ULg

in KINtop : Jahrbuch zur Erforschung des frühen Films (1995), 4

Analyse de la pratique de la vue chez Lumière, envisagée dans sa double dimension spatiale et temporelle.

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See detailInhaled nitric oxide for hemodynamic support after postpneumectomy ARDS
Chiche, Jean-Daniel; Canivet, Jean-Luc ULg; Damas, Pierre ULg et al

in Intensive Care Medicine (1995), 21(8), 675-678

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See detailProgress from 1989 to 1992 in understanding the circulation of the Western Mediterranean Sea
Lehucher, P. M.; Beautier, L.; Chartier, M. et al

in Oceanologica Acta (1995), 18(2), 255-271

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the ... [more ▼]

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the physical processes responsible for seasonal and mesoscale variabilities. Observations (in situ and satellite), together with theoretical, physical and numerical models, have been widely used in the course of these studies. Attention has been focused on the dynamics of the northern basin (deep water formation, dynamics of the Northern Mediterranean Current, circulation and shelf/slope interaction in the Balearic Sea) and of the southern basin (Alboran Sea circulation, instabilities of the Algerian Current). The straits dynamics have been studied with particular reference to the Corsica channel. Preliminary runs of a basin-scale circulation model of the Western Mediterranean Sea forced by the straits are also presented. They are shown to be capable of generating a cyclonic circulation in the western basin. [less ▲]

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See detailPneumothorax during laparoscopic fundoplication: diagnosis and treatment with positive end-expiratory pressure.
Joris, Jean ULg; Chiche, Jean-Daniel; Lamy, Maurice ULg

in Anesthesia and Analgesia (1995), 81(5), 993-1000

Pneumothorax can develop during laparoscopy, particularly during laparoscopic fundoplication, since the left parietal pleura is exposed and can be torn during dissection in the diaphragmatic hiatus. Such ... [more ▼]

Pneumothorax can develop during laparoscopy, particularly during laparoscopic fundoplication, since the left parietal pleura is exposed and can be torn during dissection in the diaphragmatic hiatus. Such an event will result in specific pathophysiologic changes, since CO2, under pressure in the abdominal cavity, will pass into the pleural space. The aim of this study was to document the pathophysiologic changes induced by pneumothorax, and to evaluate the benefit of positive end-expiratory pressure (PEEP) to treat pneumothorax. Forty-six ASA physical status I and II patients scheduled for laparoscopic fundoplication were monitored extensively; heart rate, mean arterial pressure, end-tidal CO2 (PETCO2), oxygen saturation of hemoglobin (Spo2), minute ventilation, tidal volume, dynamic total lung thorax compliance, and airway pressures were recorded. In 25 patients, oxygen uptake, CO2 elimination and arterial blood gases were also measured. Pneumothorax was diagnosed in seven patients. It resulted in the following pathophysiologic changes: decrease in total lung thorax compliance, increase in airway pressures, and increase in CO2 absorption. Consequently, PACO2 and PETCO2 also increased. Spo2, however, remained normal. The use of PEEP largely corrected these respiratory changes. None of these pneumothoraces required drainage. These data suggest that pneumothorax is common during laparoscopic fundoplication. Early diagnosis is possible by simultaneous monitoring of PETCO2, total lung thorax compliance, and airway pressures. Finally, treatment with PEEP provides an alternative to chest tube placement when pneumothorax is secondary to passage of peritoneal CO2 into the interpleural space. [less ▲]

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