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See detailLa réforme du premier degré en Communauté française de Belgique veut relever le défi d'une pédagogie de la réussite
Beckers, Jacqueline ULg

in Recherche en Education. Théorie & Pratique (1996), 5-6

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See detailLifetimes of the 3d2D levels in Ca II
Biémont, Emile ULg; Zeippen, C. J.

in Comments on Atomic and Molecular Physics (1996), 33

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See detailActeurs sociaux et perspectives préventives du hooliganisme: Orientations en guise de conclusions
Kellens, Georges ULg; Comeron, Manuel ULg

in Revue Sport (1996), 1(153), 63-64

Euro 2000: sécurité, stewards, Fan coaching

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See detailPlace de la nalbuphine (Nubain) dans l'arsenal analgésique moderne
SENARD, Marc ULg; Tazarourte, K.; Darmon, P. L.

in Urgences médicales (1996), 15

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See detailFreud, l'individu et le groupe : Hier et aujourd'hui
Carels, N.; Gauthier, Jean-Marie ULg

in Revue Belge de Psychanalyse (1996), 29

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See detailLa place des bisphosphonates dans le traitement de l’ostéoporose
Reginster, Jean-Yves ULg

in Lettre du Rhumatologue (La) (1996), 222

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See detailTreatment of osteoporosis: where are we and where are we going to
Reginster, Jean-Yves ULg

in Revista de Reumatologia (1996), 4

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See detailBrain hypometabolism of glucose in anorexia nervosa: Normalization after weight gain
Delvenne, Véronique; Goldman, Serge; De Maertelaer, Viviane et al

in Biological Psychiatry (1996), 40(8), 761-768

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex ... [more ▼]

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex-matched healthy volunteers were used as controls. Both groups were scanned during rest, eyes closed and with low ambient noise. In absolute values, the underweight anorectic patients, when compared to control subjects, showed a global (p = 0.002) and regional (p ≤ 0.001) hypometabolism of glucose which normalized with weight gain. In relative values, no global difference could be assessed between underweight anorectic patients and controls but a trend can, nevertheless, be observed toward parietal and superior frontal cortex hypometabolism associated with a relative hypermetabolism in the caudate nuclei and in the inferior frontal cortex. After weight gain, all regions normalized for absolute and relative values, although a trend appears toward relative parietal hypometabolism and inferior frontal cortex hypermetabolism in weight gain anorectic patients. Absolute brain glucose hypometabolism might result from neuroendocrinological or morphological aspects of anorexia nervosa or might be the expression of altered neurotransmission following deficient nutritional state. As some differences exists in relative values in underweight patients and tend to persist in weight gain states, this could support a potential abnormal cerebral functioning, a different reaction to starvation within several regions of the brain or different restoration rates according to the region. [less ▲]

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See detailPiroxicam fails to reduce myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise.
Croisier, Jean-Louis ULg; Camus, G.; Monfils, T. et al

in Mediators of Inflammation (1996), 5(3), 230-4

To test the hypothesis that delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of prostaglandin E(2) (PGE(2)), ten healthy male ... [more ▼]

To test the hypothesis that delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of prostaglandin E(2) (PGE(2)), ten healthy male subjects were studied. Using a double-blind randomized crossover design, each subject performed two isokinetic tests separated by a period of at least 6 weeks: once with placebo, and once with piroxicam (Feldene((R))). They were given one capsule containing either placebo or piroxicam (20 mg) per day for 6 days with initial doses given starting 3 days prior to isokinetic testing. Exercise consisted of eight stages of five maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases, on a Kin Trex device at 60( degrees )/s angular velocity. The subjective presence and intensity of DOMS were evaluated using a visual analogue scale immediately after, and 24 and 48 h after each test. The mean plasma concentration of PGE(2) measured at rest and after exercise was significantly lower in the group treated with piroxicam (p < 0.05). However, statistical analysis (two-way ANOVA test) revealed that exercise did not cause any significant change of mean plasma PGE(2) over time in either of the two groups. Eccentric work was followed by severe muscle pain in extensor and flexor muscle groups. Maximal soreness was noted 48 h postexercise. Serum creatine kinase activity and the serum concentration of myoglobin increased significantly, and reached peak values 48 h after exercise in both experimental conditions (p < 0.001). By paired t-test, it appeared that there were no significant differences in the serum levels of these two markers of muscle damage between the two groups at any time point. We conclude that: (1) oral administration of piroxicam fails to reduce muscle damage and DOMS caused by strenuous eccentric exercise; and (2) the hypothetical role of increased PGE(2) production in eccentric exercise-induced muscle damage, DOMS, and reduced isokinetic performance is not substantiated by the present results. [less ▲]

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See detailContrefaçons liégeoises et maestrichtoises de Beaumarchais. Un exercice bibliographique
Droixhe, Daniel ULg

in Bulletin de l'Institut Archéologique Liégeois (1996), 107

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See detailInteraction Of The Macrolide Azithromycin With Phospholipids .2. Biophysical And Computer-Aided Conformational Studies
Montenez, Jp.; Vanbambeke, F.; Piret, J. et al

in European Journal of Pharmacology (1996), 314(1-2), 215-27

In a comparison paper, we show the azithromycin causes a lysosomal phospholipidosis in cultured cells, binds in vitro to negatively charged bilayers without causing aggregation or fusion, and inhibits ... [more ▼]

In a comparison paper, we show the azithromycin causes a lysosomal phospholipidosis in cultured cells, binds in vitro to negatively charged bilayers without causing aggregation or fusion, and inhibits lysosomal phospholipase A1. In this paper, we show that azithromycin decreases the mobility of the phospholipids in negatively charged liposomes (using 31P nuclear magnetic resonance) and that it increases the fluidity of the acyl chains close to the hydrophilic/hydrophobic interface, but not deeper into the hydrophobic domain (assessed by measuring the fluorescence polarization of trimethylammonium-diphenylhexatriene and diphenyhexatriene, respectively). Computer-aided conformational analysis of mixed monolayers of azithromycin and phosphatidylinositol shows that the drug can be positioned largely in the hydrophobic domain, but close to the interface, with the macrocycle facing the C1 of the fatty acids (allowing the N9a endocyclic tertiary amine to interact with the phospho-groups), the cladinose located on the hydrophobic side of the lipid/water interface and the desosamine projected into the hydrophobic domain. This position is consistent with the experimental data. Analysis of virtual molecules shows that this unanticipated behavior to the shielding of the ionizable N3' amino-group in the desosamine by methyl-groups, and to the wide dispersion of hydrophobic domains all over the molecule. The interaction of azithromycin with phospholipids may account for some of its unusual pharmacokinetic properties and for its potential to cause lysosomal phospholipidosis. [less ▲]

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See detailWhat policies for biodiversity management in the Wallonia region? Biodiversity and its audiences: Sociological reflections on biodiversity protection
Mormont, Marc ULg

in Annales de Gembloux (1996), 102(1-2), 19-30

Current popular concepts of biodiversity are examined, with particular application to Belgium, using a three stage analysis. The way in which the link was made between a scientific concept and a ... [more ▼]

Current popular concepts of biodiversity are examined, with particular application to Belgium, using a three stage analysis. The way in which the link was made between a scientific concept and a sociopolitical definition is analysed. Consideration is made of society's idea of 'nature' and the 'return to nature' concept. Ways in which the public can adapt its behaviour and ideals to protect biodiversity (local ecology programmes, environmentally friendly farming etc) are examined. [less ▲]

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See detailAntipeptide antibody against the bovine IGF-BP-2 : application to the detection of BST-treated cows
Scippo, Marie-Louise ULg; Degand, Guy ULg; Duyckaerts, Anne et al

in Food & Agricultural Immunology (1996), 8

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See detailAntimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Wright, C. W.; Phillipson, J. D.; Awe, S. O. et al

in Phytotherapy Research (1996), 10

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar ... [more ▼]

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day. [less ▲]

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See detailChronique de criminologie: Quels supporters pour l'an 2000?
Kellens, Georges ULg; Comeron, Manuel ULg

in Revue de Droit Pénal et de Criminologie (1996), (3), 306-312

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See detailQuantitative measurement of metal ions concentration of proteins separated by electrophoresis
Weber, Georges ULg; Strivay, David ULg; Menendez, M. et al

in International Journal of PIXE (1996), 1-2

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the ... [more ▼]

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the electrophoresis, the gel is dried and each track is scanned with a 2.5 MeV proton beam which triggers metal X-ray fluorescence and then, allows to determine the type of metals contained in an electrophoretic band. For quantitative determination of the amount of the metal contained inside the band, the characteristic X-ray peak area is compared with those obtained with polyacrylamide gels doped with the same metal. The normalization has been achieved by using RBS measurements on the gel itself. The procedure presented seems to be a very useful multielementary method for the metal content analysis and for the determination of the metal amounts inside proteins after their separation by electrophoresis. Furthermore it allows to check if metals remain bound to proteins. [less ▲]

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See detailComplete Nucleotide Sequence Of Saccharomyces Cerevisiae Chromosome X
Galibert, F.; Alexandraki, D.; Baur, A. et al

in Embo Journal (1996), 15(9),

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See detailLa place actuelle de l'immunoanalyse en Toxicologie Clinique
Charlier, Corinne ULg; Plomteux, Guy ULg

in Immuno-Analyse & Biologie Spécialisée [=IBS] (1996), 11

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See detailLa thermographie infrarouge dans l'étude de la thermorégulation chez le cheval : effets de l'entraînement
Ghafir, Y.; Art, Tatiana ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of ... [more ▼]

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of measurements of rectal and skin temperature. The results have shown a smaller increase of rectal temperature and a greater increase of cutaneous temperature following a training period of 6 weeks. They suggest an improvement of thermoregulation via the skin. [less ▲]

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See detailInfections oculaires traumatiques et iatrogènes: prélèvements et rôle du laboratoire
Melin, Pierrette ULg

in Bulletin de la Société Belge d'Ophtalmologie (1996), 260

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological ... [more ▼]

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological diagnostic. The indications and techniques for investigations are determined by the site of infection, severity of the process, and knowledge of the likely responsible organisms. Immediate inoculation of specimens on culture media in the examining room is often recommended. This article describes organisms associated with ocular infections, and is designed to assists ophthalmologists in the collection, processing and transport of specimens. [less ▲]

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See detailEvaluation of insuline-like growth horme-I (IGF-I) and their binding proteins (IGFBPs) in pigs
Renaville, Robert ULg; Prandi, Alberto; Claes, Victor et al

in Archivio Veterinario Italiano (1996), 46

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See detailHypertension and left ventricular hypertrophy
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg; Van Cauwenberge, Henry

in Acta Cardiologica (1996), 51(2), 143-154

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age ... [more ▼]

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age, gender, weight, race, genetics and the severity of high blood pressure. By echocardiography, it has been possible to detect non invasively and more precisely this hypertrophy and its anatomical pattern which is not uniform. This cardiac response is influenced by hemodynamic but also by non hemodynamic factors, but the exact mechanisms are not yet well understood. The humoral and tropic factors particularly affect the cardiac remodeling. Left ventricular hypertrophy has been noted by itself to be an independent risk factor for sudden death, ventricular arrhythmias, myocardial ischemia, and heart failure. Very early hypertension, diastolic dysfunction is noted. The progression to systolic failure in moderate hypertension usually occurs over several decades. According to the worse prognosis of left ventricular hypertrophy, it has been suggested that the reversibility of this anatomical modification by antihypertensive treatment is beneficial. Preliminary data support this idea. [less ▲]

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See detailVoltage stability analysis in transient and mid-term time scales
Van Cutsem, Thierry ULg; Vournas, Costas

in IEEE Transactions on Power Systems (1996), 11

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See detailCompte-rendu de l'ouvrage de Doyne Dawson : Cities of the Gods : Communist Utopias in Greek Thought
Vanhaegendoren, Koen ULg

in Etudes Classiques (Namur, Belgium) (1996), 64

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See detailDetermination Of The Taxonomic Position And Characterization Of Yam Mosaic Virus Isolates Based On Sequence Data Of The 5'-Terminal Part Of The Coat Protein Cistron
Duterme, Olivier; Colinet, Dominique; Kummert, Jean et al

in Archives of Virology (1996), 141(6), 1067-1075

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See detailHumanitarian aid and health services in Eastern Kivu, Zaïre: collaboration or competition
Goyens, Philippe; Porignon, Denis ULg; Mugisho Soron'Gane, Etienne et al

in Journal of Refugee Studies (1996), 9(3), 268-280

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean ... [more ▼]

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean health services in the health districts of Rutshuru, Kirotshe and Masisi, in spite of the political and socioeconomic disintegration of the country, were still functioning, and the local hospitals and health centres, although overwhelmed, contributed to a large extent to the disaster response. Prominent among the major problems facing the local health services were their limited adaptability, the inadequate coordination and collaboration offered to them by the humanitarian aid agencies, and the discrimination between the direct and secondary victims of the emergency. The public health consequences of the Rwandan refugee crisis for the Zairean population constitute an integral part of the disaster. [less ▲]

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See detailStructure-activity relationships in platelet-activating factor (PAF).7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonist activity
Le Texier, Laurence; Favre, Edith; Redeuilh, Catherine et al

in Journal of Lipid Mediators and Cell Signalling (1996), 13

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See detailFoot: Quels supporters pour l'an 2000
Stassen, Benjamin; Comeron, Manuel ULg

in Revue Sport (1996), 1(153), 72

Football et hooliganisme: panorama européen, aspect sécuritaire et judiciaire, acteurs sociaux et perspectives préventives, Euro 2000: sécurité, stewards, fan coaching

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See detailCurrent therapies for shingles
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Expert Opinion on Investigational Drugs (1996), 5

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but ... [more ▼]

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but its moderate bioavailability renders five oral daily doses mandatory. Recent anti-VZV drug research has been oriented towards agents with increased oral bioavailability. Famciclovir and valaciclovir were originally developed as oral prodrugs for^penciclovir and acyclovir, respectively, but, together with the new antivirals, sorivudine and brovavir, they appear to be effective as oral therapy for shingles. Ongoing clinical trials will determine their relative merits in the management of shingles. The experimental agents H2G, HPMPC, mappicine ketone and A-73209 have potential in the treatment of VZV and are undergoing further investigation and development. [less ▲]

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See detailHydrology and fluvial dynamics, in Geography Research in Belgium, Comité National de Géographie, DENIS J. (Ed.)
Petit, François ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1996)

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See detailThe Ovine Callipyge Locus: A Paradigm Illustrating the Importance of Non-Mendelian Genetics in Livestock
Georges, Michel ULg; Cockett, N.

in Reproduction Nutrition Development (1996), 36(6), 651-7

An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge (CLPG) gene mapped to ovine chromosome 18. We demonstrate in this work that the callipyge ... [more ▼]

An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge (CLPG) gene mapped to ovine chromosome 18. We demonstrate in this work that the callipyge phenotype is characterized by a non-Mendelian inheritance pattern, referred to as polar overdominance, in which only heterozygous individuals having inherited the CLPG mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged. [less ▲]

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See detailCharacterization of the potato mitochondrial transcription unit containing 'native' trnS (GCU), trnF (GAA) and trnP (UGG)
Remacle, Claire ULg; MarechalDrouard, L.

in Plant Molecular Biology (1996), 30(3), 553-563

In order to identify the sequences promoting the expression of plant mitochondrial tRNA genes, we have characterized the trnS (GCU), trnF (GAA) and trnP (UGG) transcription unit of the potato ... [more ▼]

In order to identify the sequences promoting the expression of plant mitochondrial tRNA genes, we have characterized the trnS (GCU), trnF (GAA) and trnP (UGG) transcription unit of the potato mitochondrial genome. These three tRNA genes were shown to be co-transcribed as a 1800 nt long primary transcript. The transcription initiation site located 305 to 312 nt upstream of trnS is surrounded by a purine-rich region but does not contain the consensus motif proposed as a promoter element in dicotyledonous plants. Differential labelling of potato mitochondrial RNA with either guanylyltransferase or T4 polynucleotide kinase suggests that this site corresponds to the unique functional region responsible for the transcription of these three tRNA genes. The initiation site recently found upstream of Oenothera mitochondrial rr trnF does not seem to be used in potato mitochondria, although a very similar sequence is present 317 nt upstream of the corresponding potato gene. Major processing sites were identified at the 3' end of each tRNA gene. Another processing site, surrounded by a double hairpin structure, is located 498 nt downstream of trnP in stretch of 10 A residues. As judged from northern experiments, this region is close to the determination site of this transcription unit. [less ▲]

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See detailPharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Pharmacological Research (1996), 34(1-2), 9-10

The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis, to display a U-shaped configuration, with hydrophobic cycles placed at the extremity of each branch and a peptidic bond ... [more ▼]

The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis, to display a U-shaped configuration, with hydrophobic cycles placed at the extremity of each branch and a peptidic bond placed at the bottom of the U. This configuration is similar to that recently observed with the hypoglycaemic sulphonylureas glimepiride and glibenclamide and non-sulphonylurea hypoglycaemic agents of the meglitinide family, such as S3075, repaglinide, A-4166 and KAD-1229. The identification of a conformation common to these various hypoglycaemic drugs may provide an imprint of their binding site at the level of the B-cell sulphonylurea receptor. [less ▲]

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See detailParcours d’un chartiste : Robert-Henri Bautier et le recueil de ses articles
Marchandisse, Alain ULg

in Moyen Age (Le) (1996), 102

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See detailInactivated Bovine Herpesvirus 1 Induces Apoptotic Cell Death of Mitogen-Stimulated Bovine Peripheral Blood Mononuclear Cells
Hanon, E.; Vanderplasschen, Alain ULg; Lyaku, S. et al

in Journal of Virology (1996), 70(6), 4116-4120

Bovine herpesvirus 1 (BHV-1) is able to inhibit the proliferation of bovine peripheral blood mononuclear cells. Here, we have demonstrated that live BHV-1 and, interestingly, inactivated BHV-1 can induce ... [more ▼]

Bovine herpesvirus 1 (BHV-1) is able to inhibit the proliferation of bovine peripheral blood mononuclear cells. Here, we have demonstrated that live BHV-1 and, interestingly, inactivated BHV-1 can induce apoptosis of mitogen-stimulated bovine peripheral blood mononuclear cells in vitro. [less ▲]

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See detailDu Dictionnaire général de la langue wallonne à l'Atlas linguistique de la Wallonie
Boutier, Marie-Guy ULg

in Dialectes de Wallonie (1996), 23-24

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See detailChanges in gene expression in the leaf of Lolium temulentum L. Ceres during the photoperiodic induction of flowering
Périlleux, Claire ULg; Ongena, Philippe; Bernier, Georges ULg

in Planta (1996), 200(1), 32-40

Unifoliated plants of Lolium temulentum L. Ceres were induced to flower by a unique 24-h long day (LD) consisting of the extension of the regular 8-h short day (SD) (400 µmol photons·m-2·s-1, fluorescence ... [more ▼]

Unifoliated plants of Lolium temulentum L. Ceres were induced to flower by a unique 24-h long day (LD) consisting of the extension of the regular 8-h short day (SD) (400 µmol photons·m-2·s-1, fluorescence + incandescence) with incandescence at 10–15 µmol photonsm -2·s-1. The polyadenylated-RNA complement of leaf blade tissues was analysed at 4-h intervals during the photoperiod extension in LD vs. SD, by using two-dimensional polyacrylamide gel electrophoresis to resolve in-vitro-translated products. Of the 991 spots that were analysed, none appeared or disappeared during the inductive cycle, i.e. no qualitative effect of floral induction was detected, at any time. Sixty-eight spots were found whose intensity was influenced by lengthening of the photoperiod; 50 of them, i.e. ca. 5 of the population analysed, were affected before the end of the extension period and were thus potentially related to floral induction. Many of these RNAs were not quantitatively constant during a 24-h cycle in SD. Seven of them oscillated according to the ‘light-on’ and the ‘light-off’ signals, among which three seemed to be controlled by phytochrome since their relative amount increased under the standard light conditions but decreased under incandescence even faster than in darkness. The large majority of other RNAs varied with a timing that was not clearly driven by the alternation of light and darkness, indicating that genes related to the biological clock may be especially sensitive to the lengthening of the photoperiod. Furthermore, seven spots were observed that underwent a phase-shift in LD, which consisted, for six of them, of a phase advance of 4–8 h. The steady-state level of CAB mRNA was analysed because the CAB gene family (encoding the chlorophyll a/b-binding proteins of the light-harvesting complexes) is known to be controlled both by the biological clock and phytochrome. In SD, the level was high in the light and low in darkness; the fluctuation was conducted by a circadian rhythm. When plants were exposed to the inductive LD, the peak of mRNA accumulation that was expected according to the endogenous rhythmicity was abolished, possibly because of the change in light quality during the LD extension. [less ▲]

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See detailFast Computation of morphological operations with arbitrary structuring elements
Van Droogenbroeck, Marc ULg; Talbot, Hugues

in Pattern Recognition Letters (1996), 17(14), 1451-1460

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See detailMolecular Evidence That The Whitefly-Transmitted Sweetpotato Mild Mottle Virus Belongs To A Distinct Genus Of The Potyviridae
Colinet, Dominique; Kummert, Jean; Lepoivre, Philippe ULg

in Archives of Virology (1996), 141(1), 125-135

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See detailVan zwart beest tot allemansvriend
Spinoy, Erik ULg

in Muziek en woord (1996), 22(257), 2-3

This article strives to explain the striking evolution in the reception of Van Ostaijen's oeuvre: in his early years, he was a marginalized author. Nowadays, he is one of the most popular and highly ... [more ▼]

This article strives to explain the striking evolution in the reception of Van Ostaijen's oeuvre: in his early years, he was a marginalized author. Nowadays, he is one of the most popular and highly appreciated Flemish authors. [less ▲]

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See detailOn the residual advection of passive constituents
Delhez, Eric ULg

in Journal of Marine Systems (1996), 8(3-4), 147-169

In this paper, the different approaches used to simulate the long-term advection of passive constituents on tidal shelves are discussed in the framework of large scale hydrodynamic modelling. The direct ... [more ▼]

In this paper, the different approaches used to simulate the long-term advection of passive constituents on tidal shelves are discussed in the framework of large scale hydrodynamic modelling. The direct approach in which the unsteady mesoscale (tides and storm surges) and macroscale (monthly or seasonal mean processes) currents are used is very demanding in computer resources (CPU and memory). On the other hand, the use of residual velocities gives a larger understanding of the long-term transport processes and simplifies numerical treatments. However, the definition of such appropriate velocities is still an open question. In the context of large scale models, Lagrangian residuals are not applicable. Eulerian residual transport velocities fail to represent long-term motions when tidal non-linearities are important. The first order Lagrangian residual velocity introduced by Feng et al. (1986a) and generalized here is shown to be a very good solution. The North-Western European Continental Shelf (NWECS) is used as an example to compare the numerical solutions obtained with the different approaches. [less ▲]

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See detailForeword
Fontana, Roberta; Canepari, Pietro; Ghuysen, Jean-Marie ULg

in Microbial Drug Resistance : Mechanism, Epidemiology, & Disease (1996), 2(1), 5-5

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See detailFilmer la dissidence. L'écriture documentaire dans l'oeuvre des frères Dardenne
Van Cauwenberge, Geneviève ULg

in La revue belge du cinéma (1996), 41(hiver), 29-33

Detailed reference viewed: 27 (3 ULg)
See detailAuguste à Eleusis. Un aspect méconnu de l'idéologiqe augustéenne
Rochette, Bruno ULg

in Cahiers de Clio (1996), 127(automne), 3-14

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See detailDissociation of increases in plasma insulin-like growth factor I and testosterone during the onset of puberty in bulls
Renaville, Robert ULg; Massart, Serge; Sneyers, M. et al

in Journal of Reproduction and Fertility (1996), 106(1), 79-86

The present study was conducted to examine the relationship between plasma concentrations of testosterone, insulin-like growth factor I (IGF-I) and IGF-binding proteins (IGFBPs) during puberty, in male ... [more ▼]

The present study was conducted to examine the relationship between plasma concentrations of testosterone, insulin-like growth factor I (IGF-I) and IGF-binding proteins (IGFBPs) during puberty, in male calves treated with GnRH or testosterone propionate. Twelve male Holstein calves (10 weeks old) were assigned to the control group (n = 6), the GnRH-treated group (n = 3) or the testosterone-treated group (n = 3). For 8 weeks, the GnRH-treated group received a single i.v. injection of GnRH (0.5 mu g kg(-1) body mass) each day while the testosterone-treated group received an i.m. injection of testosterone propionate (0.5 mg kg(-1) body mass) twice a day. The calves were studied until they were 200 days old. Hormone treatments were stopped one month after puberty was reached in the control group. Blood samples were collected every 30 min for 8 h every third day. Hormone concentrations were determined by radioimmunoassay. Western ligand blotting and immunoblotting, using monoclonal antibodies against IGFBP-2, and IGFBP-3, were used to characterize the IGF-binding proteins. In the control group, puberty occurred at about 120 days of age and was associated with an increase in concentrations of testosterone, IGF-I and IGFBP-3 and a decrease in concentration of IGFBP-2. In the GnRH-treated group, plasma testosterone remained low until 8 weeks after establishment of puberty in the control group (4 weeks after the end of treatment). In the testosterone-treated group, testosterone was high during the treatment period and then decreased to prepubertal values when treatment was stopped. Testosterone values increased again to reach postpubertal values 5 weeks after the end of hormone treatment. Nevertheless, independent of testosterone status, the profile of IGF-I and the IGFBPs in the GnRH- and testosterone-treated groups were parallel to that reported for the control group with the transition from prepubertal to adult values at about 120 days of age. In conclusion, concentrations of testosterone, IGF-I and IGFBP-3 increase together, but probably independently, during the onset of puberty in male calves. [less ▲]

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See detailDe Bruxelles à la ferme : agriculture et environnement en Belgique
Mormont, Marc ULg

in Etudes Rurales (1996), (No. 141/142), 157-169

The implementation of environmental protection policies in Flanders and Wallonia (Belgium) is investigated, looking at the stages of application and the roles of the actors involved. The factors which ... [more ▼]

The implementation of environmental protection policies in Flanders and Wallonia (Belgium) is investigated, looking at the stages of application and the roles of the actors involved. The factors which intervene in the implementation of a European policy, whose characteristics include reformulation at local level, are identified. Structural and political factors affecting change in agricultural and environmental policies are outlined, including regionalization and the division of responsibilities. The example of Belgium shows how it is important that each authority can redefine its own interests in defending the environment using its own resources and contacts. Implementation at local level implies a series of re-interpretations of each agri-environmental measure in the light of expectations and the reactions of land-users. [less ▲]

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See detailStromelysin-3 expression promotes tumor take in nude mice
Noël, Agnès ULg; Lefebvre, O.; Maquoi, Erik ULg et al

in Journal of Clinical Investigation (1996), 97

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer experiments using both anti-sense and sense ST3 expression vectors, and malignant cells either expressing (NIH 3T3 fibroblasts) or not (MCF7 epithelial cells) endogenous ST3. We have compared the ability of parental and transfected cells to cause subcutaneous tumor development in nude mice. 3T3 cells expressing anti-sense ST3 RNA showed reduced tumorigenicity, and MCF7 cells expressing mouse or human ST3 were associated with reduced tumor-free period leading to a significant increased tumor incidence(P<10(-4)). However, once established, the ST3 expressing tumors did not grow faster than those obtained with the parental MCF7 cell line. In addition, tumors obtained after sub-cutaneous injection of ST3-expressing or nonexpressing cells did not exhibit obvious histological differences, and careful examination did not reveal any local invasive tissue areas nor systemic metastases. These in vivo observations were in agreement with those obtained in vitro showing that ST3 expression did not modify proliferative nor invasive properties of transfected cells. Altogether, these results indicate that ST3 expression promotes tumor take in nude mice, presumably by favoring cancer cell survival in a tissue environment initially not permissive for tumor growth. These findings represent the first experimental evidence showing that ST3 can modulate cancer progression. [less ▲]

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See detailUne banque de questions au service de l'évaluation formative dans l'enseignement technique du deuxième degré
Denis, Brigitte ULg; Bosmans, Catherine ULg; Jans, Véronique

in Informations pédagogiques (1996), (22), 23-33

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See detailStromelysin-3 in the biology of normal and tumoral mammary gland.
Rio, M. C.; Lefebvre, O.; Santavicca, M. et al

in Journal of Mammary Gland Biology & Neoplasia (1996), 1(2), 231-240

Stromelysin-3 (ST3) is an extracellular proteinase predominantly expressed in fibroblasts. The particular structural features andin vitro functions of this molecule suggest it could be the first member of ... [more ▼]

Stromelysin-3 (ST3) is an extracellular proteinase predominantly expressed in fibroblasts. The particular structural features andin vitro functions of this molecule suggest it could be the first member of a new subgroup of the matrix metalloproteinase family. ST3 is transiently expressed during mammary gland post-weaning involution, embryonic implantation, various organogeneses, and during amphibian metamorphosis. Moreover, ST3 is expressed in a panel of human invasive carcinomas including breast, colon, and head and neck carcinomas. Almost all ST3-expressing tissues show intense extracellular matrix remodeling activities including the loss of basement membrane integrity. Thus, either directly, or indirectly in association with other proteinases, ST3 might be involved in tissue remodeling processes occurring in both physiological and pathological processes.In vitro andin vivo studies using malignant cells stably transfected in such a way as to modulate their ST3 expression levels indicate that ST3 modifies neither cell proliferation nor invasive properties, but rather favors tumor cell survival in host tissues. This hypothesis is consistent with clinical data showing that ST3 expression could be predictive of tumor progression leading to metastases. [less ▲]

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See detailBalancing the Cenozoic carbon and alkalinity cycles: Constraints from isotopic records
Godderis, Y.; François, Louis ULg

in Geophysical Research Letters (1996), 23(25), 3743-3746

A simple model of the carbon, alkalinity and strontium cycles is built up and used to interpret the carbon and strontium isotopic evolution of seawater over the Cenozoic as recorded in marine limestones ... [more ▼]

A simple model of the carbon, alkalinity and strontium cycles is built up and used to interpret the carbon and strontium isotopic evolution of seawater over the Cenozoic as recorded in marine limestones. The idea that weathering fluxes have increased globally over the Cenozoic in response to the Himalayan uplift is critically examined. It is shown that such an increase of global weathering, postulated to explain the sharp increase in the Sr-87/Sr-86 ratio, is not compatible with the carbon isotopic record, if the budgets of carbon, alkalinity and strontium are considered simultaneously. Another scenario of the Cenozoic evolution of global weathering consistent with the carbon isotopic record is proposed in which the global weathering flux varies only slightly over the Cenozoic with a small increase between 15 Ma and the present. This second scenario appears more consistent with the reconstructed carbonate sedimentation rate and the evolution of the carbon isotopic fractionation in continental and oceanic environments. [less ▲]

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See detailEnergetic and conformational study of four benzylimidazole compounds with alpha 2 agonist profile: The mivazerol and three methylated derivatives
Vancampenhout, Nathalie; Dive, Georges ULg; Dehareng, Dominique ULg

in International Journal of Quantum Chemistry (1996), 60(4), 911-930

The mivazerol and three of its methylated derivatives are studied at the ab initio SCF level within the MINI-1 and 6-31G basis sets. This study aimed at determining some probable conformations, either ... [more ▼]

The mivazerol and three of its methylated derivatives are studied at the ab initio SCF level within the MINI-1 and 6-31G basis sets. This study aimed at determining some probable conformations, either neutral or protonated, that could interact with the alpha 2 adrenoceptors. The solvent effect was also studied within the Onsager's solvent model at the two dielectric constant (epsilon) values of 4 and 80. The interaction with the environment (either solvent or receptor) is schematically studied by positioning either two water molecules or one formamide or/and one formic add near the amide and the imidazole for few isomers. The medium polarization, through epsilon, and the solvation effect, through the interaction with the solvent molecules or the receptor side chains, stabilize the same isomers. Post-SCF calculations are performed at the CISD level, the first excited singlet and triplet states energies are determined, and the question of the wave-function stability is addressed. The results indicate the probability of a spin-orbit coupling with the first excited triplet state, thus opening the question of such a possibility within an enzyme active site. (C) 1996 John Wiley & Sons, Inc. [less ▲]

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See detailProposition for the acylation mechanism of serine proteases: A one-step process?
Dive, Georges ULg; Dehareng, Dominique ULg; Peeters, Daniel

in International Journal of Quantum Chemistry (1996), 58(1), 85-107

This work proposes a very detailed ab initio study of the hypothesis for a one-step serine protease acylation process with one water molecule acting as the main catalyst reactant. For the 11 increasing ... [more ▼]

This work proposes a very detailed ab initio study of the hypothesis for a one-step serine protease acylation process with one water molecule acting as the main catalyst reactant. For the 11 increasing complexity models considered, the minimum and transition state conformations for the reaction are determined by full geometry optimizations at the ab initio self-consistent field (scF) levels within several basis sets, from MINI-1 to 6-31G, and, for the smallest complexes, at the post-SCF MP2 level within the 6-31G** basis set. The related thermodynamical quantities are calculated for all the conformations. The influence of the oxyanion hole stabilizer and of the dyad His57-Asp102 is quantified and a very good agreement is obtained with point mutagenesis. The activation barrier is found in the range 15-18 kcal/mol. (C) 1996 John Wiley & Sons, Inc. [less ▲]

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See detailNouveaux developpements en selection animale.
Burny, A.; Portetelle, Daniel ULg; Renaville, Robert ULg

in Agricontact (1996), (287),

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See detailSerum erythropoietin in chronic lymphocytic leukaemia.
Beguin, Yves ULg; Lampertz, S.; Bron, D. et al

in British Journal of Haematology (1996), 93(1), 154-6

Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured ... [more ▼]

Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured serum Epo levels in 47 CLL patients to determine whether Epo was a significant factor in the development of their anaemia. Epo levels were increased compared to normal individuals and this elevation appeared adequate for the degree of anaemia. The slope of the regression of Epo versus haemoglobin (Hb) was similar to that of a reference group. Serum transferrin receptor (sTfR) levels were also appropriately elevated for the degree of anaemia and correlated with serum Epo. Advanced stage was not associated with reduction of Epo production but diminished erythropoietic activity was observed in several patients. The results indicate that anaemia in CLL is not characterized by inadequate Epo production. [less ▲]

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See detailThe Use Of N-15-Labeled Dietary Proteins For Determining True Ileal Amino Acid Digestibilities Is Limited By Their Rapid Recycling In The Endogenous Secretions Of Pigs
Leterme, Pascal; Thewis, André ULg; Francois, Etienne et al

in Journal of Nutrition (1996), 126(9), 2188-2198

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary ... [more ▼]

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary N excretion pattern at the ileum subsequent to the ingestion of a single 15N-labeled meal. In a second experiment, we compared ileal endogenous AA outputs and true AA digestibility estimates obtained in pigs ingesting 15N-labeled dietary proteins in a single meal vs. intravenous infusion of 15N-leucine for 10 d during the ingestion of a pea-based diet and a protein-free starch diet. The proportion of endogenous N found in the ¡leal digesta differed when the label was delivered orally (50%) vs. intravenously (72%) and changed with time. As a consequence, the true ileal AA digestibilities measured with labeled diets were lower. A third experiment demonstrated that this was due to the rapid recycling of labeled dietary N in endogenous moieties, because 15N was found in blood within 10 min of consuming the labeled meal, within 50 min of consumption in pancreatic enzymes, 90 min in bile and 4 h in ¡leal mucins. We conclude that the use of 15N-labeled meals for determination of true ¡leal AA digestibilities is limited by the fast recycling of dietary N in endogenous secretions following a single 15N-labeled meal. The accuracy of results will depend on meaningful estimates of AA flow during a limited period and accurate estimates of 15N in AA. [less ▲]

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See detailPostencephalitic stereotyped involuntary movements responsive to L-Dopa
Picard, F.; deSaintMartin, A.; Salmon, Eric ULg et al

in Movement Disorders (1996), 11(5), 567-570

In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few ... [more ▼]

In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L-Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L-Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra. [less ▲]

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See detailHomogeneous Lyapunov Functions and Necessary Conditions for Stabilization
Sepulchre, Rodolphe ULg; Aeyels, D.

in Journal of mathematics for control, signal and systems (1996), 9(1), 34-58

We provide necessary conditions for the stabilization of nonlinear control systems with the additional requirement that a time-invariant homogeneous Lyapunov function exists for the closed-loop system.

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See detailErythropoietin and the anemia of cancer.
Beguin, Yves ULg

in Acta Clinica Belgica (1996), 51(1), 36-52

The pathogenesis of the anemia of cancer involves the combination of a shortened erythrocyte survival in circulation with the failure of bone marrow to increase red cell production in compensation ... [more ▼]

The pathogenesis of the anemia of cancer involves the combination of a shortened erythrocyte survival in circulation with the failure of bone marrow to increase red cell production in compensation. Inappropriate red cell production is itself related to a conjunction of factors, including impaired availability of reticuloendothelial storage iron, inadequate erythropoietin (Epo) response to anemia, and overproduction of cytokines which are capable of inhibiting erythropoiesis. Many of these cytokines may interfere with erythropoietin production by the kidney. Consequently inadequate serum erythropoietin levels are often encountered in cancer patients, though more frequently in those with solid tumors or multiple myeloma than in those with other hematologic malignancies. There is little evidence supporting a negative impact of chemotherapy, including cisplatin, on erythropoietin production. Rather, chemotherapy usually causes a transient elevation of serum Epo. Red cell transfusions are often administered to cancer patients, possibly resulting, among other deleterious effects, in enhancement of tumor growth. Recombinant human erythropoietin (rHuEpo) has thus been proposed as an alternative. RHuEpo has been shown to be safe and effective in correcting the anemia of cancer and reducing the need for transfusions. The response rate is as good in hematologic malignancies as in solid tumors, but it is extremely poor in those with myelodysplastic syndromes. The effect of rHuEpo does not differ among patients receiving or not receiving chemotherapy, including cisplatin. The probability of response is also similar in patients with adequate or inappropriate erythropoietin production before therapy, although the doses used are usually 2 to 3 times higher than in renal failure patients. [less ▲]

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See detailSequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals
Goffin, VINCENT; Shiverick, KATHLEEN T; Kelly, PAUL A et al

in Endocrine Reviews (1996), 17(4), 385-410

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See detailAssesment of nuclear totipotency of fetal bovine diploid germ cells by nuclear transfer
Moens, André; Chesné, Patrick; Delhaize, Françoise et al

in Theriogenology (1996), 46

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See detailSera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains.
Dehan, Pierre ULg; Weber, M.; Zhang, X. et al

in Nephrology Dialysis Transplantation (1996), 11(11), 2215-22

BACKGROUND: Goodpasture (GP) syndrome is defined by the clinical association of pulmonary haemorrhage with rapidly progressive glomerulonephritis. The disease is caused by pathogenic autoantibodies ... [more ▼]

BACKGROUND: Goodpasture (GP) syndrome is defined by the clinical association of pulmonary haemorrhage with rapidly progressive glomerulonephritis. The disease is caused by pathogenic autoantibodies directed against type IV collagen, which is a major structural component of glomerular basement membranes (GBM). METHODS: The non-collagenous domains (NC1) of all six human type IV collagen alpha chains was produced in E. coli as recombinant fusion proteins with glutathione-S transferase. Sera from 10 patients with different types of anti-GBM nephritis, including GP syndrome, were tested for reactivity with the six proteins using immunoblotting of denatured and reduced proteins and ELISA without reduction. RESULTS: All 10 sera reacted with the alpha 3 (IV) collagen chain by immunoblotting and ELISA. One serum also recognized the alpha 2(IV), alpha 4(IV), alpha 5(IV) and alpha 6(IV) chains by immunoblotting. ELISA measurements revealed reactivity of several other sera with alpha 2(IV), alpha 4(IV) or alpha 6(IV) but not with alpha 5(IV) collagen chains. No reactivity was observed with the alpha 1(IV) chain. CONCLUSION: Autoantibodies in anti-GBM nephritis may not be directed only against the alpha 3(IV) collagen chain and they frequently recognize conformational epitopes. [less ▲]

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See detailDetection And Identification Of Sweet Potato Viruses By The Polymerase Chain Reaction
Colinet, D.; Lepoivre, Philippe ULg; Xia, Fz. et al

in Agro Food Industry Hi-Tech (1996), 7(2),

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See detailMortality in Oryzaephilus surinamensis following short-term exposure to conditioned kernels by high-density culture
Mignon, Jacques ULg; Haubruge, Eric ULg; Lienard, Valérie et al

in Entomologia Experimentalis et Applicata (1996), 80(3), 555-557

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See detailCase management voor psychogeriatrishe patiënten: de case manager
Borgermans, L.; Milisen, K.; Dejace, Alain ULg et al

in Acta Hospitalia (1996), 4

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See detailEvaluation de l'effet apaisant d'un dermocosmétique: Soin intense apaisant
Nikkels, Arjen ULg; Jacquet, A.; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1996), 15

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation ... [more ▼]

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation and sites chromametry) and indirect investigations (corneocyte harvesting and chromametric analysis) have been conducted. The excellent correlation between the results has lead us to prove a very obvious soothing effect of SOIN INTENSE APAISANT (care range Hydrocapteur of Castalia, Laboratoires Lavipharm). [less ▲]

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See detailRelationships between growth, cannibalism and survival rate in intensively cultured larvae and alevins of perch (Perca fluviatilis)
Mélard, Charles ULg; Baras, E.; Mary, L. et al

in Annales Zoologici Fennici (1996), 33

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See detailOccurrence and impact of Heteropolaria (Protozoa: Ciliophora), on intensively cultured perch Perca fluviatilis
Grignard, J. C.; Mélard, Charles ULg; Baras, E. et al

in Annales Zoologici Fennici (1996), 33

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See detailContamination of European otters (Lutra lutra) by PCB congeners and organochlorinated pesticides in the wetlands of western France
Tans, Michael; Hugla, Jean Louis; Libois, Roland ULg et al

in Netherlands Journal of Zoology (1996), 46(3-4), 326-336

During the forty years, otter (Lutra lutra) populations have severely declined over much of Europe. One of the main regression factors appears to be pollution by organochlorine xenobiotics, especially ... [more ▼]

During the forty years, otter (Lutra lutra) populations have severely declined over much of Europe. One of the main regression factors appears to be pollution by organochlorine xenobiotics, especially PCBs. The present study took place in France, in the wetlands of the Atlantic border, where otter populations are considered to the stable. Muscle, pericaudal fat, and liver of 33 otters were analysed for 22 PCB congeners and organochlorine pesticides. The mean concentrations of organochlorinated pesticides in samples are relatively low (from 0 to 5.71 mg/kg lipid weight). The PCB concentrations are higher (mean in muscular tissue: 26.19 mg/kg lipid weight), but still remain low compared to similar samples from other countries. The relation between PCB concentration and physiological variables is discussed. Congener specific analysis shows an important contamination due to highly chlorinated congeners and a poor contaminatin due to low chlorinated congeners. Potential hazards due to organochlorinated compounds are also discussed. [less ▲]

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See detailSemantic memory and amnesia: A case study
Van der Linden, Martial ULg; Brédart, Serge ULg; Depoorter, N. et al

in Cognitive Neuropsychology (1996), 13(3), 391-413

The performance of a severe amnesic patient (AC) was explored across two tasks designed to assess his public and personal semantic knowledge before and after the onset of his amnesia.

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See detailArthrite septique du boulet : corrélation entre imagerie et examen anatomo-pathologique
Busoni, Valeria ULg; Rossi, Giacomo; Denoix, Jean-Marie

in Pratique Vétérinaire Equine (1996), 28

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See detailLocalization of nucleic acids in hepatocyte nucleoli of rats upon D-galactosamine-induced block of transcription.
Mikhaylova, V. T.; Thiry, Marc ULg; Stephanova, E. et al

in Experimental Cell Research (1996), 225(2), 389-98

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection ... [more ▼]

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection: osmium-ammine staining and terminal deoxynucleotidyl transferase reaction for DNA, and immunoelectron microscopy with anti-RNA antibodies, RNase-gold, and autoradiography with tritiated orotic acid for RNA. The blocking of transcription was followed by the disappearance of intranucleolar condensed chromatin. Agglomerates of thin extended DNA filaments were found to change their location to the nucleolar periphery and to coalesce with each other. At the last stage of nucleolar segregation they were concentrated at the pole of the nucleolar fibrillar remnant while the rest of the nucleolus did not contain any DNA. No DNA was found in the dense fibrillar component of both intact and treated hepatocyte nucleoli. During the process of nucleolar segregation the bulk of the nucleolar RNA was found within the so-called spherical bodies. This RNA appeared to be synthesized shortly before or even after drug administration. The results obtained are in agreement with the hypothesis that the fibrillar centers are the site of nucleolar transcription. They also show that uncompleted molecules of pre-rRNA whose synthesis has been blocked are segregated from the rest of nucleolar RNA species into the spherical bodies. [less ▲]

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See detailAn improved preparation method of benzyl and thenyl triphenylphosphonium salt
Zhang, Jian-Xin; Dubois, Philippe ULg; Jérôme, Robert ULg

in Synthetic Communications (1996), 26(16), 3091-3095

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine ... [more ▼]

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine can also be converted within high yields to phosphonium salts by removing the formed water by azeotropic distillation. Solvent (methylene chloride, chloroform and acetonitrile) and temperature have been chosen in close relation to the alcohol reactivity. Purification is straightforward and yields are relatively high. [less ▲]

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See detailInsulin action in man.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1996), 22(2), 105-10

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is ... [more ▼]

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues and for the prevention of excessive gluconeogenic substrate production. Various methods have been developed to assess insulin action in vivo, essentially at liver and muscle sites. Such methods evaluate the effect of exogenous or endogenous insulin, using respectively the open-loop approach (interruption of the feedback loop by inhibiting endogenous insulin secretion) or the closed-loop approach (mathematical modelling of the insulin-glucose feedback loop). Knowledge of the successive steps of cellular insulin action has markedly improved during the last ten years. Preceptor, receptor and postreceptor levels need to be considered since they may be affected in insulin-resistant states. This general progress in the understanding of insulin action in man improves our approach to the complex pathophysiology of non-insulin-dependent diabetes mellitus and opens up new prospects for treatment of the insulin-resistant syndrome which is associated with several atherosclerotic risk factors. [less ▲]

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See detailRelationship between Parathion and Paraoxon Toxicokinetics, Lung Metabolic Activity, and Cholinesterase Inhibition in Guinea Pig and Rabbit Lungs
Lessire, Françoise ULg; Gustin, Pascal ULg; Delaunois, Annie et al

in Toxicology and Applied Pharmacology (1996), 138(2), 201-210

Kinetic parameters of parathion and paraoxon uptake were determined in isolated and perfused rabbit and guinea pig lungs. They were related to organophosphate-induced lung cholinesterase inhibition. A ... [more ▼]

Kinetic parameters of parathion and paraoxon uptake were determined in isolated and perfused rabbit and guinea pig lungs. They were related to organophosphate-induced lung cholinesterase inhibition. A single pass procedure was used to perfuse the lungs with an artificial medium perfusate containing paraoxon or parathion. The paraoxon and parathion concentrations were determined in the effluents collected at chosen intervals over an 18-min period beginning at the start of perfusion. Three inflowing concentrations (1 nmol/ml, 10 nmol/ml, and 20 nmol/ml) were tested in guinea pig lungs and one (10 nmol/ml) in rabbit lungs. Cholinesterase activity was determined at time 0 and at the end of the experiment. The lungs abundantly extracted paraoxon and parathion over the perfusion period. The extraction ratio was consistently greater in guinea pig than in rabbit lungs. The uptake velocity varied biexponentially in time, suggesting the existence of two compartments. Initial uptake velocities (A, B) and slopes (alpha and beta) were calculated for both compartments. In guinea pigs, A, B and A + B increased proportionally to the supply rate of paraoxon and parathion while a and b remained constant. No significant difference was observed between parathion and paraoxon uptake kinetics. Parameter B was the only one to differ significantly between the two species (rabbits: 8.19 +/- 1.53 for parathion and 6.85 +/- 1.26 for paraoxon; guinea pigs: 12.75 +/- 0.88 for parathion and 15.02 +/- 3.84 for paraoxon). In the lungs of both species, there was a linear relation between y, the percentage of cholinesterase inhibition induced by either organophosphate, and X, the total amount of drug taken up by the lung tissue (in nmol/g/18 min). The following equations were obtained: y = 0.128 x + 0.979 (R2 = 0.89, p < 0.001 for paraoxon); y = 0.120 x - 6.57 (R2 = 0.82, p < 0.005 for parathion). No difference was observed between the two organophosphates. After treatment with the cytochrome P450 inhibitor piperonyl butoxide, the above relations ceased to apply, but this treatment did not influence the kinetics of paraoxon and parathion uptake. The IC50 value calculated for paraoxon, i.e., the paraoxon concentration required to produce 50% inhibition of lung cholinesterase activity, was similar for guinea pigs (2.22 10(-7) +/- 0.22 M) and rabbits (2.36 10(-7) +/- 0.24 M). In conclusion, the biexponential evolution of the velocity of paraoxon and parathion uptake by the lungs thus demonstrates the presence of two pools. The lower extraction ratios calculated for rabbit lungs reflect the lower initial uptake velocity of the second compartment. In the range of concentrations investigated in guinea pigs, no saturable mechanism could be demonstrated for paraoxon and parathion. Cytochrome P450-related lung metabolic activity, through which parathion is converted to paraoxon, appears as a major step in parathion-induced lung cholinesterase inhibition, although it does not appear to affect parathion toxicokinetics [less ▲]

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See detailAssessment of residual insulin secretion in diabetic patients using the intravenous glucagon stimulatory test: methodological aspects and clinical applications.
Scheen, André ULg; Castillo, M. J.; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1996), 22(6), 397-406

Defective insulin secretion plays a crucial role in insulin-dependent (Type 1) and non-insulin-dependent (Type 2) diabetes mellitus as well as in many secondary forms of the disease. Glucagon is a potent ... [more ▼]

Defective insulin secretion plays a crucial role in insulin-dependent (Type 1) and non-insulin-dependent (Type 2) diabetes mellitus as well as in many secondary forms of the disease. Glucagon is a potent stimulus for the islet beta-cell, and intravenous bolus injection of 1 mg glucagon has been widely used to assess endogenous insulin secretion for clinical or research purposes. Plasma C-peptide levels (less commonly insulin) are usually measured immediately before and 6 min after glucagon injection. The C-peptide response to glucagon is well-correlated with the beta-cell response to mixed meals or other stimuli commonly used to characterize endogenous insulin secretion (oral or intravenous glucose, standard meals, arginine, etc.) and has the advantage of shorter duration and simple standardization. The glucagon test shows good intra-subject reproducibility, although in diabetic patients it may be influenced by variable prevailing blood glucose levels. Several applications of the glucagon test have been developed. In Type 1 diabetes, the glucagon test has been used to discriminate between patients with and without residual insulin secretion. This can be especially important during the first few months, or even years, following initiation of insulin therapy when attempts to stop the immunological destruction of the beta-cell are made. Assessment of endogenous insulin secretion is also important after pancreas or islet transplantation. In patients with Type 2 diabetes mellitus, in which residual endogenous insulin secretion is common, characterization of the disease may help in the choice of therapy for the individual patient (insulin, sulphonylureas or combined therapy). Thus, the glucagon test is a simple, reliable and useful tool for clinical evaluation of diabetes mellitus. [less ▲]

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See detailLa gale psoroptique bovine. Une maladie éradicable ?
Mignon, Bernard ULg; Lonneux, J. F.; Losson, Bertrand ULg

in Sillon Belge (1996), 20.12.1996

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See detailRelationships of polymorphisms for growth hormone and growth hormone receptor genes with milk production traits for Italian Holstein-Friesian bulls
Falaki, M.; Gengler, Nicolas ULg; Sneyers, M. et al

in Journal of Dairy Science (1996), 79(8), 1446-1453

Allelic variation in the structural or regulatory sequences of growth hormone and its receptor genes might directly or indirectly affect milk traits. This possibility prompted us to investigate the ... [more ▼]

Allelic variation in the structural or regulatory sequences of growth hormone and its receptor genes might directly or indirectly affect milk traits. This possibility prompted us to investigate the eventual relationships of restriction fragment length polymorphisms at the locus of bovine growth hormone (using TagI and MspI restriction enzymes) and its receptor (using TaqI restriction enzyme) production traits of bulls. Holstein-Friesian bulls were used in this experiment, and data were analyzed with a fixed linear model. The restriction fragment length polymorphisms at the growth hormone locus did not affect the milk traits studied. Six restriction enzyme TaqI bands of 7.1, 6.2, 5.7, 5.4, 4.2, and 3.3 kb with nine patterns were observed after hybridization by a cDNA probe containing the coding sequences for the intracellular C-terminal part of the receptor. The effect of this polymorphism on PTA for milk protein percentage was highly significant and was favorable for the rare (6.6%) 5.7- and 5.4-kb pattern. Our results indicate that further study is needed to explain the DNA polymorphism and to obtain more definite conclusions about effects on milk traits. [less ▲]

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See detailNucleic acid detection by in situ molecular immunogold labeling procedures.
Thiry, Marc ULg

in Scanning Microscopy. Supplement (1996), 10

We have recently combined immunogold labeling procedures with molecular biology methods to pinpoint the precise locations of nucleic acids in biological material at the ultrastructural level. These new ... [more ▼]

We have recently combined immunogold labeling procedures with molecular biology methods to pinpoint the precise locations of nucleic acids in biological material at the ultrastructural level. These new immunocytological approaches involve the incorporation of labeled nucleotides in the nucleic acids present at the surface of ultrathin sections prior to immunogold labeling. The antibodies used recognize a nucleoside analogue (bromodeoxyuridine) or a hapten (biotin) employed to label nucleotides. Examples of high-resolution detection include DNA or RNA present in different substructures of cell nuclei, and in particular, in adenovirus-induced intranuclear regions of HeLa cells. In addition to being highly sensitive and specific, these new methods offer the possibility of studying the spatial distribution of nucleic acids in very well preserved, readily recognizable structures. [less ▲]

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See detailGenome mapping of Clostridium perfringens strains with I-Ceul shows many virulence genes to be plasmid-borne.
Katayama, S.; Dupuy, B.; Daube, Georges ULg et al

in Molecular & General Genetics [=MGG] (1996), 251

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See detailLanguage in adults with Down syndrome
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Down's Syndrome, Research and Practice : The Journal of the Sarah Duffen Centre (1996), 4(1), 3-14

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language ... [more ▼]

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language or some aspects of it beyond adolescence and during the adult years? This question is related to the issue of a critical period for language development raised by Eric Lenneberg (1967). Third, what is the effect of ageing on the language of persons with Down syndrome, including those who develop Alzheimer disease in old age? [less ▲]

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See detailPhase transition and thermodynamics of a hot and dense system in a scaled NJL model
Cugnon, Joseph ULg; Jaminon, Martine ULg; Van den Bossche, Bruno

in Nuclear Physics A (1996), 598

he chiral phase transition of a hot and dense system of quarks is studied within a modified SU(3) NJL Lagrangian that implements the QCD scale anomaly. The u- and s-quark condensates can or can not feel ... [more ▼]

he chiral phase transition of a hot and dense system of quarks is studied within a modified SU(3) NJL Lagrangian that implements the QCD scale anomaly. The u- and s-quark condensates can or can not feel the same chiral restoration depending on the considered region of the three-dimensional space (Tc, muuc, musc). The temperature behaviour of the pressure and the energy and entropy densities of the u- and s-quark system is investigated. At high temperature, the non-vanishing bare s-quark mass only modifies slightly the usual behaviour associated with an ideal quark gas. [less ▲]

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See detailSuppression of Voluntary Temporalis Muscle Activity by Peripheral Limb Stimulations in Healthy Volunteers, Migraineurs and Tension-Type Headache Sufferes
Wang, W.; Schoenen, Jean ULg

in Functional Neurology (1996), 11(6, Nov-Dec), 307-15

We studied the inhibition of voluntary temporalis muscle activity after stimulations of extracephalic cutaneous or mixed nerves in 23 healthy volunteers, 29 patients suffering from migraine without aura ... [more ▼]

We studied the inhibition of voluntary temporalis muscle activity after stimulations of extracephalic cutaneous or mixed nerves in 23 healthy volunteers, 29 patients suffering from migraine without aura, 24 from episodic and 42 from chronic tension-type headache. Two successive EMG suppressions were induced bilaterally after stimulating at 40 mA the index finger or the median nerve, but not after stimulations of the sural or peroneal nerves. They differed from those obtained after labial commissure stimulation at 20 mA, i.e. the classic temporalis silent periods ES1 and ES2. Overall prevalence of index- (3%) and median nerve-induced (16%) early suppression was much lower than that of labial-induced ES1 (100%); prevalence of index-induced late suppression (index-"ES2") was 62% and that of median-"ES2" 48%, compared with 97% for labial-ES2. Latency and duration of index-/median-"ES2" were not significantly different between groups. Index-"ES2" occurred significantly more often in migraineurs (83%) than in controls (48%) suggesting that the spino-bulbar pathways involved in index-/median-"ES2" are hyperexcitable in migraine. [less ▲]

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See detailChemical Composition Of Pea Fibre Isolates And Their Effect On The Endogenous Amino Acid Flow At The Ileum Of The Pig
Leterme, Pascal; Thewis, André ULg; Van leeuwen, Piet et al

in Journal of the Science of Food and Agriculture (1996), 72(1), 127-134

Pea starch, hulls and cotyledon inner fibres, isolated from pea seeds, were incorporated in N-free diets, on a NDF-content basis, in order to study their effect on the ileal endogenous amino acid (AA ... [more ▼]

Pea starch, hulls and cotyledon inner fibres, isolated from pea seeds, were incorporated in N-free diets, on a NDF-content basis, in order to study their effect on the ileal endogenous amino acid (AA) excretion in the growing pig. Maize starch and wood cellulose were selected as references. The inner fibrecontaining diet was also supplemented with enzymatically hydrolysed casein (EHC) in order to test the peptide alimentation method on a diet containing a fibre source with a high water-holding capacity (WHC = 10.9 g water g-' DM). The fibres were also analysed by different methods (crude fibre, NDF, ADF, enzymatic-gravimetric method, Englyst method). The fibre content of the inner fibre fraction varied widely from one method to another and ranged from 109 g crude fibre to 480 g AOAC fibre kg-' DM. Compared to the 'maize starch + wood cellulose' diet (11.0 g AA excreted kg-' DM intake), pea starch had no effect on ileal AA losses (9.6 g), whereas pea hulls slightly increased them (14.2 g). The AA excretion dramatically increased with the incorporation of inner fibres (28.0 g), because of their very high WHC. The addition of EHC increased the output (48.0 g) further, at a level that can hardly be explained only by an increase of the endogenous secretions. The results suggest that the NDF content of grain legume products is not indicative of their effect on the ileal endogenous AA losses in pigs and that the physiological effects of fibres along the gastrointestinal tract are due to both their chemical and physical properties. [less ▲]

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See detailPorous biomaterials tailored for cell culture.
Grandfils, Christian ULg; Maquet, V; Ropson, N et al

in Cytotechnology (1996), 21

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See detailTreatment of gypsum waste in a two stage anaerobic reactor
Deswaef, Sophie; Salmon, Thierry ULg; Hiligsmann, Serge ULg et al

in Water Science & Technology (1996), 34(5-6), 367-374

The reduction of high concentrations of gypsum (up to 110 kg/m(3)) is investigated in a two stage immobilised cell bioreactor. The first stage is mainly colonised by a consortium of acidogenic bacteria ... [more ▼]

The reduction of high concentrations of gypsum (up to 110 kg/m(3)) is investigated in a two stage immobilised cell bioreactor. The first stage is mainly colonised by a consortium of acidogenic bacteria and sulphate reducing bacteria oxidising volatile fatty acids with more than 2 carbons (mainly, butyrate and propionate). The gypsum consumption rate is rather high (ii kg/m(3).day). Most of acetate remains unconverted in this first stage. It is partially converted in the second stage (residence time : 12 days) which is predominantly colonised by acetate oxidising bacteria The gypsum consumption rate is much lower than in the first stage : 3 kg/m(3).day. With both stages, it is possible to reach an almost complete conversion of gypsum with an overall capacity of 6.1 kg gypsum/m(3).day. We propose also a very simple model to describe the different transformation rates. It allows us to clearly identify the activity levels of the different types of sulphate reducing bacteria in both stages. Copyright (C) 1996 IAWQ. [less ▲]

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See detailThe seasonality of the CO2 exchange between the atmosphere and the land biosphere: A study with a global mechanistic vegetation model
Nemry, B.; François, Louis ULg; Warnant, Pierre ULg et al

in Journal of Geophysical Research (1996), 101(D3), 7111-7125

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR ... [more ▼]

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR), and a mechanistic model of carbon assimilation in the biosphere (CARAIB) that estimates the net primary production (NPP) of continental vegetation. The steady state hypothesis of the biosphere allows the spatial distribution and the global content of the soil carbon to be expressed as a function of the root fractions of soil respiration under forested and herbaceous vegetation covers. The sensitivity of the modeled CO2 signal to the wind field does not exceed the observed interannual variability. The influence of the various vegetation zones is quantified by the Fourier analysis of the modeled atmospheric signal. In the northern hemisphere, the temperate ecosystems dominate the seasonal atmospheric signal of the extratropical latitudes. The ecosystems of the tropical northern zone determine the local signal, while the southern tropical ecosystems influence largely the signal in the whole southern hemisphere. The results give credence to the mechanistic modeling of NPP since the simulated atmospheric signal is comparable with that obtained with normalized difference vegetation index (NDVI) based diagnostic models coupled with a parameterization of SHR fitted to optimize the atmospheric signal. [less ▲]

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See detailMyocellular Enzyme Leakage, Polymorphonuclear Neutrophil Activation and Delayed Onset Muscle Soreness Induced by Isokinetic Eccentric Exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Deby-Dupont, G. et al

in Archives of Physiology & Biochemistry (1996), 104(3), 322-9

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product ... [more ▼]

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product prostaglandin E2 (PGE2). 10 healthy male subjects were submitted to eccentric and concentric isokinetic exercises on a Kin Trex device at 60 degrees/s angular velocity. Exercise consisted of 8 stages of 5 maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases. There was an interval of at least 30 days between eccentric and concentric testing, and the order of the two exercise sessions was randomly assigned. The subjective presence and intensity of DOMS was evaluated using a visual analogue scale, immediately, following 24 h and 48 h after each test. Five blood samples were drawn from an antecubital vein: at rest before exercise, immediately after, after 30 min recovery, 24 h and 48 h after the tests. The magnitude of the acute inflammatory response to exercise was assessed by measuring plasma levels of polymorphonuclear elastase ([EL]), myeloperoxidase ([MPO]) and PGE2 ([PGE2]). Using two way analysis of variance, it appeared that only eccentric exercise significantly increased [EL] and DOMS, especially of the hamstring muscles. Furthermore, a significant decrease in eccentric peak torque of this muscle group only was observed on day 2 after eccentric work (- 21%; P < 0.002). Serum activity of creatine kinase and serum concentration of myoglobin increased significantly 24 and 48 h after both exercise tests. However, these variables reached significantly higher values following eccentric contractions 48 h after exercise. Mean [PGE2] in the two exercise modes remained unchanged over time and were practically equal at each time point. On the basis of these findings, we conclude that the magnitude of polymorphonuclear (PMN) activation, muscle damage, and DOMS are greater after eccentric than after concentric muscle contractions. However, the hypothesized interplay between muscle damage, increased PGE2 production, DOMS sensations, and reduced isokinetic muscle performance was not substantiated by the present results. [less ▲]

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See detailMiospores from the type locality of the middle Famennian Esneux Formation in the Ourthe Valley, eastern Belgium
Loboziak, S; Avkhimovich, V I; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1996), 119(2), 111-118

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See detailSuperconductivity fluctuation effects on the thermal conductivity of Bi2Sr2CaCu2O8
Houssa, M.; Bougrine, Hassan ULg; Stassen, S. et al

in Physical Review. B : Condensed Matter (1996), 54(10), 6885-6888

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional ... [more ▼]

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional (2D) to 3D behavior theoretically predicted by Varlamov and Livanov is well marked. The crossover temperature T-VL and the amplitude of the fluctuation contribution lead to realistic values for the interlayer coupling energy J(C) and the transport relaxation time tau near T-c. [less ▲]

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See detailA Possible Role for the Alpha 1-->3 Galactosyl Epitope and the Natural Anti-Gal Antibody in Oncogenesis
Gollogly, L.; Castronovo, Vincenzo ULg

in Neoplasma (1996), 43(5), 285-9

Glycoconjugates and their antibodies are vital components of host-tumor interaction. This review concentrates on the oncological implications of research concerning the alpha gal triad; the alpha 1-->3 ... [more ▼]

Glycoconjugates and their antibodies are vital components of host-tumor interaction. This review concentrates on the oncological implications of research concerning the alpha gal triad; the alpha 1-->3 galactosyl epitope (alpha Gal), the enzyme responsible for its construction, alpha 1,3 galactosyl transferase (alpha 1-3GT), and its associated antibody: anti-gal. Alpha gal epitopes, previously assumed to be absent from human tissue, have been demonstrated on several human cancer cell lines, senescent red blood cells, and Graves' disease thyrocytes. Alpha-gal presence on neoplastic lines is correlated with increased metastatic formation in animal models. The mechanisms of human response to these neoantigens are complex, as natural anti-gal antibodies exist in high titers in normal sera, thus predicting immunological recognition of cells expressing alpha gal epitopes. Hypotheses vary regarding the pathogenic contributions of metastasis-associated phenomena such as de novo expression of alpha gal and its unmasking by desialylation. The means by which alpha gal is sporadically expressed in human tissue remain unknown, as the galactosyl transferase which produces this epitope in constitutively expressive animals has undergone significant mutation at the genomic level in humans. Pathological re-expression is presumed to require permissive changes at a cellular level. Detailing these alterations is a prerequisite to the comprehension of the metastatic phenotype. In this context, the possibility of therapeutic strategies affecting alpha gal expression are also discussed. [less ▲]

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See detailL’ὕβρις dans le mythe d'Idas et Lyncée
Renaud, Jean-Michel ULg

in Uranie : Mythes et Littératures (1996), 6

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See detailTaurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats
Dahchour, Abdelkhader; Quertemont, Etienne ULg; De Witte, Philippe

in Brain Research (1996), 735

The extracellular changes of amino acids glutamate, taurine and GABA in the nucleus accumbens of freely moving rats were estimated using the microdialysis technique following acute and chronic ethanol ... [more ▼]

The extracellular changes of amino acids glutamate, taurine and GABA in the nucleus accumbens of freely moving rats were estimated using the microdialysis technique following acute and chronic ethanol injections (1, 2, and 3 g/kg body weight). Compared to baseline values, taurine increased by 154%, 142% and 162%, 20 min after the acute injection of, respectively, 1, 2 and 3 g/kg body weight ethanol, while 40 min after ethanol injection, taurine had increased by 124%, 146% and 168%. No changes in either glutamate or GABA were detected at any time points assayed. In the rats which had received chronic ethanol administration prior to a further acute ethanol injection (1, 2, and 3 g/kg body weight), taurine increased by 138%, 144% and 180%, 20 min after the ethanol injection, and at 40 min post ethanol injection taurine had increased by 134%, 160% and 158%, compared to the basal baseline value. No significant changes were observed in either glutamate or GABA microdialysate content in these chronic studies. The biological role played by taurine after acute ethanol injection in the nucleus accumbens remains unclear but may be associated with a yet, undefined mechanism, in reducing the cytotoxicity of ethanol. [less ▲]

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See detailThymic insulin-like growth factors (IGFs) in man and in an animal model of autoimmune IDDM
Geenen, Vincent ULg; Achour, Imane; Kecha, Ouafae et al

in Diabetologia (1996), 39

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