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See detailHemodynamic effects of intratracheal administration of Pasteurella haemolytica in calves
Amory, Hélène ULg; Linden, Annick ULg; Desmecht, Daniel ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailEvaluation de la violence scolaire à travers des transgressions auto-révélées
Egido, A.; Born, Michel ULg

in Cahiers de l'IPSA (1995), 17

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See detailQuantitative assessment of erythropoiesis in haemodialysis patients demonstrates gradual expansion of erythroblasts during constant treatment with recombinant human erythropoietin.
Beguin, Yves ULg; Loo, Martine; R'Zik, Samir ULg et al

in British Journal of Haematology (1995), 89(1), 17-23

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anaemia of chronic renal failure. It has been reported that reticulocytes as well as erythroid progenitors ... [more ▼]

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anaemia of chronic renal failure. It has been reported that reticulocytes as well as erythroid progenitors increase within 1-2 weeks, with no further elevation beyond this time interval. However, the erythroblast pool is quantitatively the most important compartment of erythropoiesis, and the rate, extent and duration of the expansion of erythropoietic activity in response to rHuEpo is not known. Treatment with rHuEpo was given to 64 patients i.v. thrice weekly after haemodialysis. The effect of rHuEpo was obvious from the early elevation of reticulocyte counts, but much of this increase was due to a rapid output of shift reticulocytes which levelled off after a few weeks. Serum transferrin receptor (TfR), a quantitative measure of erythropoiesis, increased progressively over 6 weeks to reach a plateau phase at about twice baseline values. The Hct increased progressively and continued to rise steadily after the TfR plateau was reached. The speed and extent of the expansion of erythropoietic activity correlated with the later haematological response to rHuEpo. When rHuEpo was discontinued, erythropoietic activity returned progressively to baseline values, to rise again gradually when treatment was resumed. Part of the Hct increase was also due to haemoconcentration. The results indicate that changes in the various erythroid compartments vary considerably in intensity and speed, and that the erythroblast compartment in particular is slow to respond to modifications in the erythropoietin stimulus. [less ▲]

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See detailMapping quantitative trait loci controlling milk production by exploiting progeny testing
Georges, Michel ULg; Nielsen, D.; Mackinnon, M. et al

in Genetics (1995), 139

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny ... [more ▼]

We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding. [less ▲]

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See detailMusiques Cajun, Creole et Zydeco en Louisiane Francophone
Sacré, Robert ULg

in Cahiers du Jazz (Les) (1995), 6

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See detailGrowth hormone, Insulin-like growth factor-I and their plasma binding proteins in different cattle breeds
Renaville, Robert ULg; Devolder, Anne; Shojae, Djalil et al

in Zootecnica e Nutrizione Animale (1995), 21

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See detailEtiologie et physiopathologie du diabète de type 2.
SCHEEN, André ULg; PAQUOT, Nicolas ULg; Lefevre, P.

in Problèmes Actuels d'Endocrinologie et de Nutrition (1995), 10

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See detailApplication of sucrose synthase from rice grains for the synthesis of carbohydrates.
Elling, Lothar; Grothus, Marita; Zervosen, Astrid ULg et al

in Annals of the New York Academy of Sciences (1995), 750

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are ... [more ▼]

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are required as substrates for glycosyltransferases. Activated sugars are usually synthesized by pyrophosphorylases from nucleoside triphosphates and sugar-l-phosphates.'.* For cyclic in situ regeneration, at least three enzymes are needed, which makes the synthesis of, for example, N-acetyllactosamine very complex by established procedure. We report here on the enzymatic synthesis of saccharides and activated sugars by the plant glycosyltransferase sucrose synthase (EC 2.4.1.13)! The glycosyltransferase has the unique feature of catalyzing in vitro the synthesis and cleavage of sucrose (SCHEME1 ). The main advantage of sucrose synthase over pyrophosphorylases is the utilization of nucleoside diphosphates (NDP) instead of nucleoside triphosphates to generate activated sugars. [less ▲]

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See detailIS THE PRESENCE OF MESOTROPHIC PLANT-COMMUNITIES IN THE PEAT-BOGS OF HAUTES-FAGNES (BELGIUM) CONNECTED WITH TONALITE INTRUSIONS IN THE REVINIAN LAYERS
Hambuckers, Alain ULg; Schumacker, René ULg; Remacle, Jean ULg et al

in Belgian Journal of Botany (1995), 128(1), 48-56

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species ... [more ▼]

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species. Based on the fact that there are several outcrops of tonalite in the region and particularly one in the Nature Reserve, a hypothesis to explain these singularities of the vegetation implies discontinuities of the bedrock provoked by intrusions of this magmatic rock in the Revinian layer covering the region. Seventeen plots containing Phragmites australis were examined and vegetation was described. Silt and soil water were sampled and analyzed for mineral contents in 15 sites. The differences of mineral composition between the P. australis plots and their surrounding environment confirmed the more mesotrophic characteristics of these plots (i.e. higher pH, higher Ca and Mg contents, lower Al content). However, the lower Zn, Pb and Fe contents would lead to reject the hypothesis of intrusions of tonalite since these elements are more abundant in the tonalite and its mineralization than in the Revinian rock. Nevertheless, the overall ecological conditions of the examined plots and the differences of plant species composition suggested that the observed chemical environment could be evoked for explaining the distribution of the mesotrophic species in the oligotrophic environment of the Nature Reserve. Consequently, an alternative hypothesis is proposed. [less ▲]

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See detailBrazilandia. Over Brazil van John Updike.
Vanden Berghe, Kristine ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(1), 112-114

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See detailFear reactions of domestic sheep confronted with either a human or a human-like model
Bouissou, Marie-France; Vandenheede, Marc ULg

in Behavioural Processes (1995), 34

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See detailUtilisation des biopesticides pour la protection de pommes en conservation.
Jijakli, Mohamed ULg; Lepoivre, Philippe ULg

in Fruit Belge (1995), 63(455), 83-88

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See detailAnalysis of Liquid Flow Distribution in Trickling Flow Reactor Using Computer-Assisted X-Ray Tomography
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Chemical Engineering Research & Design : Transactions of the Institution of Chemical Engineers Part A (1995), 73(A3), 258-262

In this paper, we propose a new experimental technique, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling flow reactors. Tomography refers to the ... [more ▼]

In this paper, we propose a new experimental technique, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling flow reactors. Tomography refers to the cross-sectional imaging of an object from data collected by illuminating this object from many directions. The experimental set-up allows the scanning of transverse sections of rather large columns: up to 0.8 m diameter and 2 m height can be irradiated. Experiments were carried out both without and with liquid flow. In the absence of liquid, the reconstructed images give a view of the non-uniformity of the solid phase distribution. The images obtained are very complex because they result from the superposition of several distributions with different Spatial scales. We show the existence of a first spatial scale which allows us to separate properties belonging to the individual packing elements from those belonging to the bed scale. When liquid is flowing through the packed bed X-ray scans give a clear picture of the distribution of the liquid phase saturation, despite the very low liquid film thickness. Average values of this liquid phase saturation are determined and confronted with a partial wetting model. [less ▲]

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See detailRegime et tactique alimentaires de la loutre (Lutra lutra) en France: synthèse.
Libois, Roland ULg

in Cahiers d'Ethologie (1995), 15(2-3-4), 251-274

More than 1500 otter spraint samples have been collected in different aquatic habitats throughout the present geographic range of the otter in France. Prey remains were identified, the relative occurrence ... [more ▼]

More than 1500 otter spraint samples have been collected in different aquatic habitats throughout the present geographic range of the otter in France. Prey remains were identified, the relative occurrence and abundance of each species was assessed and the biomass of each individual prey estimated. When available, data about the fish communities (size frequency- distributions, relative abundance) were compared with the diet of the mustelid. The main conclusions of the study are as follows: 1. The otter is mainly piscivorous but some other aquatic (crayfish) or semiaquatic preys (frogs, Natrix-snakes, some birds and mammals) are of major dietary importance in oligotrophic habitats. 2. The composition of the diet is determined by the local fish resources. The otter is an opportunistic predator, its diet varying greatly from one place to another. The diet can also change depending upon the season or upon some special circumstances such as frog or fish reproduction or strong prey-community changes. 3. Small fish are dominant in the diet. No size selection has been evidenced at least in the eel and in the cyprinid fishes. As far as the trout is concerned, it seems that the otter consumes preferably medium sized individuals. 4. The proportion of some prey species is lower in the diet than in the habitat. These are the more pelagic (bleak, sander, breams), rheophilic (dace, chub) or group-living species (minnow, roach). Bottom- (bullhead, eel, tench, gudgeon, barbel) or plant-living (rudd, pike) species are more frequent. [less ▲]

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See detailPacemaker Implantation for Early Sinus Node Dysfunction after Orthotopic Heart Transplantation
RADERMECKER, Marc ULg; Defraigne, Jean-Olivier ULg; Fourny, J. et al

in Acta Chirurgica Belgica (1995), 95(1), 31-4

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node ... [more ▼]

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node dysfunction were identified and were satisfactorily paced on the VVIR mode. All three showed sinus recovery within three months following implantation and had their pacemaker switched from the VVIR mode to a simple ventricular demand pacing. Interestingly, administration of beta-blocking drugs quickly reinstituted pace dependence. The patients' outcome is excellent (18 to 48 months follow-up). No difference with the global cohort of our OHT recipients was noticed, apart from an apparent high incidence of infections (3/3) with (2/3) CMV and severe rejection (3/3) during the first month postoperatively. This data suggests that sinus dysfunction may be the result of a multifactorial (rejection, CMV, ...) injury to the conduction system, and is only clinically relevant beyond a threshold level. Denervation hypersensitivity, together with correction of these factors, may account for the restoration of a sufficient reserve of conduction system, and therefore appropriate sinus node function in basal conditions. [less ▲]

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See detailBiochemical analysis of cytoplasmic and mitochondrial Asn-tRNA synthetase functions in two mutant yeast strains.
Landrieu, Isabelle; Vandenbol, Micheline ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103

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See detailFormer par les stages
Jadoulle, Jean-Louis ULg

in Pédagogies. Cahiers du Laboratoire de Pédagogie Expérimentale de l'Université de Louvain (1995), X

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See detailVariations temporelles de la phénologie et de la composition biochimique de la phanérogame marine Posidonia oceanica en baie de Calvi
Gobert, Sylvie ULg; Belkhiria, Samy; Dauby, Patrick ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1995), 64

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See detailShort administration of metformin improves insulin sensitivity in android obese subjects with impaired glucose tolerance.
Scheen, André ULg; Letiexhe, Michel ULg; Lefebvre, Pierre ULg

in Diabetic Medicine : A Journal of the British Diabetic Association (1995), 12(11), 985-9

In a double-blind, randomized, cross-over study, the metabolic effects of a short treatment with metformin (2 x 850 mg day-1 for 2 days and 850 mg 1 h before evaluation) were compared to those of placebo ... [more ▼]

In a double-blind, randomized, cross-over study, the metabolic effects of a short treatment with metformin (2 x 850 mg day-1 for 2 days and 850 mg 1 h before evaluation) were compared to those of placebo in 15 obese subjects (BMI: 33.2 +/- 0.9 kg m-2), with abdominal distribution of adipose tissue and impaired glucose tolerance. An intravenous glucose tolerance test (0.3 g glucose kg-1) was performed after each period of treatment. Areas under the curve (AUC0-180 min) were calculated for plasma glucose, insulin, and C-peptide levels. Glucose tolerance was estimated by the coefficient of glucose assimilation (KG). Insulin sensitivity (SI) and glucose effectiveness (SG) indices were calculated using Bergman's minimal model. Insulin secretion rate (ISR) was determined by deconvolution of plasma C-peptide levels and insulin metabolic clearance rate (MCR) was estimated by dividing AUC 1SR by AUC insulin. Fasting plasma insulin levels were reduced after metformin (89.3 +/- 15.9 vs 112.4 +/- 24.3 pmol l-1; p = 0.04). AUC glucose, KG and SG were similar in both tests. However, AUC insulin was reduced (39.7 +/- 6.5 vs 51.8 +/- 10.4 nmol min l-1; p = 0.02), while SI (6.98 +/- 1.14 vs 4.61 +/- 0.42 10(-5) min-1 pmol-1 l; p = 0.03) and insulin MCR (715 +/- 116 vs 617 +/- 94 ml min-1 m-2; p = 0.03) were increased after metformin. The demonstration that metformin rapidly improves insulin sensitivity should encourage further research to evaluate the long-term effects of metformin in android obese subjects with impaired oral glucose tolerance. [less ▲]

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See detailSurface Molecular Structure of Self-Assembled Alkanethiols Evidenced by UPS, Synchrotron Radiation and HREELS
Duwez, Anne-Sophie ULg; Riga, Joseph; ghijsen, Jacques et al

in Journal of Electron Spectroscopy & Related Phenomena (1995), 76

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See detailModified glucagon test allowing simultaneous estimation of insulin secretion and insulin sensitivity: application to obesity, insulin-dependent diabetes mellitus, and noninsulin-dependent diabetes mellitus.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Journal of Clinical Endocrinology and Metabolism (1995), 80(2), 393-9

The aim of this study was to describe an adaptation of the glucagon test allowing the simultaneous characterization of insulin secretion and sensitivity. A glucagon test (1 mg/m2) was performed in healthy ... [more ▼]

The aim of this study was to describe an adaptation of the glucagon test allowing the simultaneous characterization of insulin secretion and sensitivity. A glucagon test (1 mg/m2) was performed in healthy subjects (n = 11), obese patients (n = 5), insulin-dependent diabetics (n = 9), nonobese noninsulin-dependent diabetics (n = 7), and overweight noninsulin-dependent diabetics (n = 8). Previously, they had been connected to the Biostator, modified for continuous blood collection. Endogenous insulin secretion induced by glucagon was derived from integrated C-peptide concentrations. An index of insulin sensitivity was obtained by dividing the rate of decrease in blood glucose by the total amount of insulin entering the circulation (secreted+infused by the Biostator). The indices of insulin sensitivity obtained in the above groups of subjects were, respectively, 0.064 +/- 0.006, 0.030 +/- 0.006, 0.037 +/- 0.007, 0.021 +/- 0.006, and 0.016 +/- 0.002 mmol/L.U.min (P < 0.001). The estimated insulin secretion values in the 20 min following glucagon injection were, respectively, 0.38 +/- 0.05, 0.65 +/- 0.08, 0.05 +/- 0.01, 0.26 +/- 0.15, and 0.30 +/- 0.07 U (P < 0.001). The insulin sensitivity index obtained from this test correlated with the glucose MCR obtained from a euglycemic glucose clamp (r = 0.816; P < 0.001; n = 12). C-Peptide levels after glucagon administration were also significantly correlated with the estimated endogenous insulin secretion (r = 0.808; P < 0.001; n = 30). This adaptation of the classical glucagon test is an efficient and simple method to simultaneously evaluate insulin secretion and insulin sensitivity. [less ▲]

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See detailLack of LTR and ENV genetic variation during bovine leukemia virus-induced leukemogenesis.
Willems, Luc ULg; Kerkhofs, P.; Burny, A. et al

in Virology (1995), 206(1),

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See detailPhysical Properties of Particles of Ipratropium and Clenbuterol Generated by Equipment Suitable for the Inhalation of Drugs by Calves
Genicot, Bruno; Lapp, K.; Close, Roland et al

in Research in Veterinary Science (1995), 59(2), 164-167

When solutions of ipratropium and clenbuterol were atomised at 300 kPa and 450 kPa in equipment suitable for the inhalation of drugs by calves, the numbers, velocities and diameters of the particles ... [more ▼]

When solutions of ipratropium and clenbuterol were atomised at 300 kPa and 450 kPa in equipment suitable for the inhalation of drugs by calves, the numbers, velocities and diameters of the particles produced were similar. When the pressure was increased to 600 kPa more of the particles were less than 2 microns in diameter and fewer were more than 7 microns in diameter, the fractions of the total mass of the solution generated in these size ranges were similarly increased and decreased, and the velocities of the particles were increased. At any given pressure, the numbers of particles of different sizes, and the proportions of the total mass generated, were similar for the solutions of ipratropium and clenbuterol, but a solution of saline produced more particles with a diameter less than 3 microns. Particles from the solution of ipratropium had the highest velocity and particles from the solution of clenbuterol had the lowest velocity. [less ▲]

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See detailEstimation de la disponibilite de la ressource forestiere. Cas d'une essence traitée en futaie équienne monospecifique.
Hebert, Jacques ULg; Laurent, Christian

in Revue Forestière Française (1995), 47(5), 572-580

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See detailDeux chansons relatives à des imprimeries liégeoises du XVIIIe siècle
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1995), 268

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See detailEffect of high osmolarity acclimation on tolerance to hyperosmotic shocks in L929 cultured cells.
Gilles, Raymond ULg; Belkhir, M.; Compère, Philippe ULg et al

in Tissue & Cell (1995), 27(6), 679-687

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin ... [more ▼]

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin. This paper shows that; 1) this phenomenon is concomitant with a complete disappearance of deoxyribonucleic acid, as visualized by immunogold labelling, from the nucleoplasmic spaces; 2) acclimation to high osmolarities (600 mOsm) by addition to the culture medium of NaCl, sorbitol or proline protects the cells from these effects, which appear to be largely attenuated-acclimated cells also survive much better to the osmotic shock than do control cells and; 3) the best protection seems to be provided by sorbitol and NaCl. Proline acclimation is less effective. These effects are discussed in terms of increased tolerance to NaCl load induced at the level of different macromolecules by so-called 'compensatory' organic compounds. [less ▲]

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See detailCharacterization of monoclonal antibodies against stromelysin-3 and their use to evaluate stromelysin-3 levels in breast carcinoma by semi-quantitative immunohistochemistry
Santavicca, M.; Noël, Agnès ULg; Chenard, M. P. et al

in International Journal of Cancer = Journal International du Cancer (1995), 64(5), 336-341

Stromelysin-3 (ST3) is a matrix metalloproteinase which is expressed in fibroblastic cells of most human invasive carcinomas and represents a potential new prognostic indicator. Expression of recombinant ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase which is expressed in fibroblastic cells of most human invasive carcinomas and represents a potential new prognostic indicator. Expression of recombinant ST3 forms in Escherichia coli from cDNA constructs indicated that high levels of expression were achieved when the ST3 pro-domain was deleted. The putative mature form of ST3 thus produced and recovered from bacterial inclusion bodies was used to prepare monoclonal antibodies (MAbs) against ST3 by immunization of BALB/C mice. Ten hybridomas producing MAbs against ST3 were obtained and analyzed for their ability to detect endogenous ST3 in breast cancer and in conditioned media from human fibroblasts. One of these MAbs (5ST-4A9) was found to be suitable for the routine detection of ST3 on breast cancer tissue sections, thus opening the possibility to evaluate ST3 prognostic value in breast cancer using semi-quantitative immunohistochemistry [less ▲]

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See detailAnomalous pion decay in effective QCD at finite temperature
Blaschke, David; Jaminon, Martine ULg; Kalinovsky, Yu. L. et al

in Nuclear Physics A (1995), 592

The width of the process π0 → γγ is calculated within effective QCD at finite temperature. We use two different effective models which describe chiral symmetry breaking and its restoration at finite ... [more ▼]

The width of the process π0 → γγ is calculated within effective QCD at finite temperature. We use two different effective models which describe chiral symmetry breaking and its restoration at finite temperature in SU(2)ƒ: (i) an effective lagrangian with a nonlocal separable interaction kernel, (ii) A- and B-scaledNJL lagrangians which implement the scale anomaly of QCD. We calculate the temperature dependences of the quark and pion masses as well as of the pion-park-antiquark coupling strength below and above the double quark mass threshold. At zero temperature we obtain a fairly good agreement with the experimental value for the decay width. The temperature dependence of the decay width is related to that of the pion mass. Γπ0 → γγ is enhanced in the vicinity of the Mott temperature (Mπ = 2mq) for the nonlocal as well as for the A-scaled model and suppressed for the B-scaled model. We compare our results with the SU(2) Nambu-Jona-Lasinio model which is contained as a limiting case in our approach. [less ▲]

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See detailThermographie routière nocturne de la Région Wallonne : méthodologie, présentation des résultats et intérêts de l'approche topoclimatologique
Funcken, Ph.; Erpicum, Michel ULg; Frédéric, Marc ULg et al

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailDifferential effects of drawing and indirect dopamine agonists on the induction of gnawing in C57BI/6J mice
Tirelli, Ezio ULg; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1995), 273(1), 7-15

Compared the ability of indirect dopamine (DA) agonists to induce gnawing behavior (GB) in male C57BL/6J mice with that of direct DA agonists acting at DA D-sub-1 or D-sub-2 receptor subtypes. Eight Ss ... [more ▼]

Compared the ability of indirect dopamine (DA) agonists to induce gnawing behavior (GB) in male C57BL/6J mice with that of direct DA agonists acting at DA D-sub-1 or D-sub-2 receptor subtypes. Eight Ss were used per dose. Holes left by Ss on corrugations of packing cardboard were used as an objective index of GB. Indirect DA agonists, including DA releasers such as fencamfamine and amfonelic acid and DA uptake inhibitors such as cocaine and nomifensine, produced dose-dependent increases in GB. None of the direct agonists (e.g., apomorphine, quinpirole) increased GB. The dopaminergic nature of GB was confirmed in studies in which a host of compounds (e.g., nicotine, caffeine, dizocilpine) with primary actions at nondopaminergic sites did not induce GB. Given the general contrast between the effects of direct and indirect DA agonists, this procedure could serve as a rapid in vivo method of distinguishing direct- from indirect-acting DA agonists. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailEfficacité des solutions envisagées par des enseignants en formation face à des problèmes rencontrés dans des leçons d’éducation physique
Beckers-Ledent, Maryse; Cloes, Marc ULg; Delfosse, Catherine et al

in Revue de l'Education Physique (1995), 35(4), 173-179

La recherche sur l'efficacité de l'enseignement s'est concrétisée et a trouvé application dans plusieurs ouvrages de didactique. Elle a été menée à partir de données directement observables, les ... [more ▼]

La recherche sur l'efficacité de l'enseignement s'est concrétisée et a trouvé application dans plusieurs ouvrages de didactique. Elle a été menée à partir de données directement observables, les comportements et stratégies d'enseignement dans l'action en classe. L'observation des comportements des enseignants, des élèves et des interactions entre ces différents acteurs a contribué à identifier des variables du processus en relation positive ou négative avec les progrès des élèves. ... [less ▲]

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See detailMolecular biology in support of an old paradigm about the induction of flowering
Périlleux, Claire ULg

in Flowering Newsletter (1995), 20

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See detailRetinopathy, but not neuropathy, is influenced by the level of residual endogenous insulin secretion in type 2 diabetes.
Bozet, Marie-Claire ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Diabète & Métabolisme (1995), 21(5), 353-9

The files of 132 patients with Type 2 diabetes were retrospectively studied to characterize the influence of metabolic control and residual insulin secretion on neuropathy and retinopathy, the two most ... [more ▼]

The files of 132 patients with Type 2 diabetes were retrospectively studied to characterize the influence of metabolic control and residual insulin secretion on neuropathy and retinopathy, the two most frequent degenerative diabetic complications. Patients were classified according to their metabolic control (mean HbA1C either < or > or = 8%; reference values: 3-6%) and residual endogenous insulin secretion (fasting plasma C-peptide levels either < or > or = 0.600 nmol/l). Neuropathy was more frequent in patients with poor metabolic control (32/64 = 50%) than in those adequately controlled (17/68 = 25%; p < 0.005). In both subgroups, the level of endogenous insulin secretion did not influence the prevalence of neuropathy. Retinopathy was less effected than neuropathy by the degree of metabolic control (37.5% in the subgroup with HbA1C > or = 8% v.s. 25% in the subgroup with HbA1C < 8%; p < 0.10), but was influenced by residual insulin secretion. Indeed, in patients with inadequate metabolic control, the prevalence of retinopathy was significantly increased in those with higher endogenous insulin secretion (51.4 versus 20.6%, p < 0.02) and thus probably higher insulin resistance. Furthermore, higher systolic arterial blood pressure was observed in the subgroups with a higher prevalence of retinopathy. Such conclusions were confirmed using multivariate analysis. Thus, in Type 2 diabetes, neuropathy is essentially affected by the degree of metabolic control, whereas retinopathy is also influenced by the level of residual endogenous insulin secretion and the presence of systolic hypertension. [less ▲]

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See detailA general functional characterization of the microlocal singularities
Bastin, Françoise ULg; Laubin, Pascal

in Journal of Mathematical Sciences, The University of Tokyo (1995), 2(1), 155-164

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See detailIncreased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel disease.
Louis, Edouard ULg; Louis, Renaud ULg; Drion, V. et al

in Allergy (1995), 50(9), 729-33

Although bronchopulmonary manifestations are rare in inflammatory bowel disease (IBD), subclinical abnormalities have been described in up to 50% of cases. The pathophysiology of these abnormalities ... [more ▼]

Although bronchopulmonary manifestations are rare in inflammatory bowel disease (IBD), subclinical abnormalities have been described in up to 50% of cases. The pathophysiology of these abnormalities remains unknown. However, a latent inflammation of the bronchial mucosa secondary to the inflammation of the intestinal mucosa has been suggested. This subclinical inflammation may lead to increased bronchial responsiveness. We studied the bronchial responsiveness in 38 inflammatory bowel disease (IBD) patients, using the methacholine test. Bronchial hyperresponsiveness was defined by a PC20M < 16 mg/ml. Twenty-four healthy controls were also studied. There was no significant difference in baseline FEV1 between IBD patients and controls. However, there was a significantly greater fall in FEV1 in the IBD patients at the concentrations of methacholine tested. The frequency of bronchial hyperresponsiveness was significantly higher in the IBD population (45%) than in controls (17%; P < 0.03). Atopy, defined by skin test, was more common in IBD patients (42%) than in controls (21%). Even when only nonatopic subjects were considered, the frequency of bronchial hyperresponsiveness was significantly higher in IBD patients (41%) than in controls (5%; P < 0.02). Thus, subclinical bronchial hyperresponsiveness is common in IBD, and may be considered a further extraintestinal manifestation. [less ▲]

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See detailneuroendocrinology in the perinatal period
Battisti, Oreste ULg

in mini acta of belgian society of pediatrics (1995), 27

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See detailNuclear transplantation using bovine primordial germ cells from male fetuses.
Delhaise, F.; Ectors, Fabien ULg; de Roover, R. et al

in Reproduction, Fertility and Development (1995), 7(5), 1217-9

The developmental potential of nuclei of bovine gonial cells was investigated by nuclear transfer. Gonial cells were collected from male fetuses at about 175 days post coitum (p.c.). They were fused with ... [more ▼]

The developmental potential of nuclei of bovine gonial cells was investigated by nuclear transfer. Gonial cells were collected from male fetuses at about 175 days post coitum (p.c.). They were fused with enucleated oocytes; reconstituted embryos were cultured in vitro for 7 days. Embryos reaching the compacted morula or blastocyst stage were either fixed for cell counting or transferred into recipients. Out of 115 oocyte-gonia fusions, 101 (87.8%) gave rise to cleaved embryos at Day 3 and 26 (22.6%) had reached the 8-cell stage. At Day 7, 1 (1%) developed to the morula stage and 5 (4%) reached the blastocyst stage. Three blastocysts were fixed and showed normal cell numbers (135; 90; 76 cells). Three blastocysts and one morula were transferred in four recipients; two recipients were pregnant at Day 21 but only one was positive at Day 35 p.c.; this last one aborted around Day 40 p.c. No conceptus was collected. These results indicate that gonial cell nuclei can be partially reprogrammed; they are able to develop into blastocysts and to initiate gestation. However, more experiments will be necessary to prove the nuclear totipotency of bovine gonial cells. [less ▲]

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See detailIn vitro modulation of keratinocyte attachment by minocycline H-Cl
Van Heusden, Alain ULg; Rompen, Eric ULg; Lebfevre, P. et al

in Journal of Dental Research (1995), 74

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See detailProfondeville/Rivière: Grotte du "Bois Laiterie"
Noiret, Pierre ULg

in Chronique de l'Archéologie Wallonne (1995), 3

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See detailTransient respiration locomotion decoupling in galloping thoroughbreds
Jolly, Sandra ULg; Art, Tatiana ULg; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1995), 18(suppl), 13-17

The compulsory respiration locomotion coupling may sometimes be broken in healthy galloping horses, leading to a `big respiratory cycle' (BRC). This work is aimed at describing the ventilatory pattern of ... [more ▼]

The compulsory respiration locomotion coupling may sometimes be broken in healthy galloping horses, leading to a `big respiratory cycle' (BRC). This work is aimed at describing the ventilatory pattern of the BRC and at studying the influence of the individual horse, gallop speed and training. Eleven healthy Thoroughbred horses were studied during a 9 week period of incremental training intensity. Instantaneous respiratory airflow, tidal volume, respiratory rate and the 02 and C02 fraction in inspired and expired gases were continuously obtained on a breath-by-breath basis during 4 standardised treadmill exercise tests (SET) performed at 3 week intervals. The inspiratory airflow of the BRC had a bi- or triphasic shape and ils inspiratory time was 1.5-fold longer than that of a normal breath. The expiratory flow was monophasic and lasted 2.5-fold longer than the normal breath. The inspiratory, but not the expiratory peak flows, remained unchanged during the BRC. The inspiratory volume was 2.0-to 1.5-fold higher than normal, according to the gallop speed. Each BRC was followed by a`readjustment cycle' (RC), which allowed the recovery of normal respiration locomotion coupling. The sum of BRC + RC times always equalled the time for 3 normal respiratory cycles. The sum of the inspiratory volumes of BRC and RC was significantly higher than the sum of their expiratory volumes. There was a highly significant effect of horse and of training on the frequency of BRC. Lastly, during the BRC and at least the 4 following respiratory cycles, the end-tidal 02 and CO, fractions were significantly lower and higher respectively. It was hypothesised that this respiratory manoeuvre could result from a negative feedback mechanism providing, at least, transiently either a readjustment of the end expiratory lung volume or an improvement of the pulmonary gas exchange [less ▲]

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See detailGrowth hormone response to apomorphine in panic disorder: comparison with major depression and normal controls.
Pichot, W.; Hansenne, Michel ULg; Gonzalez Moreno, A. et al

in European Archives of Psychiatry & Clinical Neuroscience (1995), 245(6), 306-8

Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 ... [more ▼]

Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 male drug-free inpatients meeting Research Diagnostic Criteria for panic disorder who were compared with 10 male major depressive inpatients and 10 male normal controls. The three groups differed significantly in the GH peak response (mean +/- SD): 27.8 +/- 12.5 ng/ml in panics, 5.4 +/- 4.0 ng/ml in major depressives, and 25.8 +/- 11.3 ng/ml in normal controls (F(2,27) = 15.3; P = 0.00003). Although there were significant differences between panics and major depressives (P = 0.00004), and between major depressives and controls (P = 0.00004), panics did not significantly differ from controls. These results do not support the hypothesis of an overlap between panic and affective disorders, and suggest that the hypothalamo-GH-somatomedin axis could be intact in panic disorder. [less ▲]

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See detailRegulation of gill prolactin receptors in tilapia (Oreochromis niloticus) after a change in salinity or hypophysectomy
Auperin, B.; Rentier-Delrue, Françoise ULg; Martial, Joseph ULg et al

in Journal of Endocrinology (1995), 145(2), 213-20

Prolactin (PRL) receptors in gill tissue have been analyzed in tilapia (Oreochromis niloticus) after transfer from fresh water (FW) to brackish water (BW). This study has indicated the presence of only ... [more ▼]

Prolactin (PRL) receptors in gill tissue have been analyzed in tilapia (Oreochromis niloticus) after transfer from fresh water (FW) to brackish water (BW). This study has indicated the presence of only one class of tilapia PRL (tiPRL) receptor whatever the salinity. After transfer, however, the percentage of specific binding of the two forms of tiPRL (tiPRLI and tiPRLII) increased significantly. Scatchard analysis of tiPRLI binding indicated an increase in receptor affinity, an effect which was not accompanied by any change in receptor specificity. Transfer to BW also caused the number of tiPRL receptors to increase rapidly, remaining high in fish adapted to BW for 28 days. Based on the sharp reduction in plasma tiPRLI and tiPRLII levels after transfer to BW, one possible explanation may be that tiPRL itself is an important factor regulating the number of free receptors. This hypothesis finds support in the fact that the number of tiPRL receptors also increased in hypophysectomized fish reared in FW. However, the absence of change in receptor affinity after hypophysectomy suggested that yet other factors are involved in tiPRL receptor regulation during the transfer from FW to BW. The paradoxically high numbers of tiPRL receptors in the gills of BW-adapted tilapia, even though PRL is known to be a FW-adapting hormone, is discussed with regard to the environment in which tilapia live. [less ▲]

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See detailVentilatory and arterial blood gas tension adjustments to strenuous exercise in standardbreds
Art, Tatiana ULg; Lekeux, Pierre ULg

in American Journal of Veterinary Research (1995), 56(10), 1332-1337

Five healthy, fit Standardbreds (mean +/- SEM, 490.4 +/- 15.0 kg, 4.0 +/- 0.5 years) were studied during a standardized test carried out on a treadmill. The test consisted of an 8-minute warm-up and a 9 ... [more ▼]

Five healthy, fit Standardbreds (mean +/- SEM, 490.4 +/- 15.0 kg, 4.0 +/- 0.5 years) were studied during a standardized test carried out on a treadmill. The test consisted of an 8-minute warm-up and a 9-minute exercise period (1 minute at 1.7, 4, 7, 8, 9, and 10 m/s; 2 minutes at 4 m/s; and a 1-minute walk at a 6% slope). Respiratory airflow, tidal volume (V(T)), and respiratory frequency (f) were continuously recorded, using 2 ultrasonic pneumotachographs connected to a face mask and mass spectrometer. Oxygen uptake, carbon dioxide output, and expired minute volume (V(E)) were obtained on a breath by breath basis. Arterial blood was tested at the end of each step for O2 and CO2 partial pressures. Heart rate was continuously recorded, using a heart rate recording system. Stride frequency was measured at each step, and the stride frequency-to-f ratio was calculated. Venous blood was tested for plasma lactate concentration be fore and 2 minutes after completion of the test. Some horses had a locomotion-respiration coupling (LRC), but this coupling was occasional and intermittent. The f was lower and V(T) was higher than values reported for thoroughbreds working under similar experimental conditions. Nevertheless, maximal V(E) did not overshoot maximal V(E) reported in Thoroughbreds. All horses were hypoxemic and hypercapnic, but there was wide variability between subjects. The horses with the highest oxygen uptake and the lowest plasma lactate concentration were more hypoxemic and hypercapnic. The Standardbreds, studied under our laboratory conditions, did not have constant LRC and had lower f with higher V(T) than did Thoroughbreds under similar experimental conditions. Despite these differences in breathing strategy, the Standardbreds did not have higher V(E) than did Thoroughbreds, and they were hypoxemic and hypercapnic. The fact that these Standardbreds, which obviously freely selected their breathing strategy, were unable or unwilling to adopt compensatory hyperventilation reinforces the hypothesis that, in strenuous exercising horses, there could be a physiologic limit to ventilation, most probably related to mechanical factors, but independent of any LRC. [less ▲]

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See detailInfluence of creep on the microstructure of Zn-Al-Cu alloys aged at 250°C
Terziev, L.; Lecomte-Beckers, Jacqueline ULg; Wegria, J.

in Physica Status Solidi A : Applied Research (1995), 152[2]

This paper is a continuation of a microstructural study of ZA alloys subjected to ageing at different temperatures with subsequent creep at 20 and 120 °C. it was already established that the samples aged ... [more ▼]

This paper is a continuation of a microstructural study of ZA alloys subjected to ageing at different temperatures with subsequent creep at 20 and 120 °C. it was already established that the samples aged for one week at 100 and 250 °C show the slowest creep rate. Furthermore, the resuits obtained afler ageing at 250 °C are better than those obtained after ageing at 100 °C. In order to explain more correctly these resuits, the microstructure is studied after ageing at 250 oc and subsequent creep at room temperature under pressure at 100 MPa and at 120 °c under pressure at 40 MPa, on test samples broken after the respective creep. [less ▲]

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See detailEvaluacion del comportamiento agressivo en ninos preescolares
Born, Michel ULg; Egido, A.; Pire, B.

in Revista Galega de Psicopedagogia (1995), 12(8), 149-165

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See detailThe Cenozoic evolution of the strontium and carbon cycles: Relative importance of continental erosion and mantle exchanges
Godderis, Y.; François, Louis ULg

in Chemical Geology (1995), 126(2), 169-190

The past variations of the seawater Sr-87/Sr-86 isotopic ratio are related to changes in the relative contribution of the mantle Sr input to the ocean and the Sr supply from continental weathering ... [more ▼]

The past variations of the seawater Sr-87/Sr-86 isotopic ratio are related to changes in the relative contribution of the mantle Sr input to the ocean and the Sr supply from continental weathering. Recently, it has been postulated that the Cenozoic increase in the seawater Sr-87/Sr-86 isotopic ratio was associated with the uplift of the Himalayan and Andean mountains at that time. These orogenies may have changed the Sr isotopic ratio of the continental rocks undergoing weathering (as a result of extensive metamorphism), increased the river flux of Sr through enhanced weathering in these regions and possibly caused the global climatic cooling trend of the Cenozoic. A model of the major geochemical cycles coupled to an energy balance climate model is used to explore the possible causes of the Mesozoic-Cenozoic fluctuations in the seawater Sr-87/Sr-86 isotopic ratio. The contribution of the mantle exchanges at mid-ocean ridges, of the recycling of seafloor carbonates through plate margin volcanism and of the alteration of seafloor basalts to the fluctuations of the seawater Sr-87/Sr-86 isotopic ratio are studied. Finally, this model tentatively describes the impact of the Himalayan orogeny on the geochemical cycles of Sr and C. Some possible effects of the extensive metamorphism associated with the India-Asia collision and of the Himalayan uplift are modelled. The model reproduces the Cenozoic increase of the seawater Sr-87/Sr-86 isotopic ratio. However, the impact of the Himalayan orogeny on the C cycle appears to be limited and insufficient to generate the global climatic cooling of the Cenozoic. Rather, in the model, the Cenozoic cooling is mostly due to the reduction of the CO2 emission from mid-ocean ridge volcanism and to changes in the chemical weathering rates in the rest of the world excluding the Himalayas. [less ▲]

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See detailMonoclonal antibodies against bovine growth hormone (bGH) enhance the biological response to GH by prolonging GH binding to its liver receptors.
Beauloye, V.; Muaku, S. M.; Portetelle, Daniel ULg et al

in Endocrinology (1995), 136(Suppl 1), 344

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See detailCeci est mon corps
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5),

This is a special issue on the body in literature and art.

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See detailRéalisation d'un appareillage mesure de l'anisotropie magnétique et application aux supraconducteurs à haute température critique
Vanderbemden, Philippe ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1995), 12

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See detailDesign for polarizing holographic optical elements
Habraken, Serge ULg; Renotte, Yvon; Roose, Stéphane ULg et al

in Applied Optics (1995), 34(19), 3595-3602

We present results of the application of a three-dimensional rigorous-vector coupled-wave theory to the design of polarizing holographic optical elements. Two different cases have been selected giving ... [more ▼]

We present results of the application of a three-dimensional rigorous-vector coupled-wave theory to the design of polarizing holographic optical elements. Two different cases have been selected giving rise to two types of element, one of which is completely original. Experimental realizations were performed. The recording material was dichromated gelatin because of its outstanding performance related to diffraction efficiency. A fair agreement between the theoretical previsions and the experimental results was achieved. [less ▲]

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See detailEffects of PEEP on systemic vascular compliance in intact pigs
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailAttitude of a Young Surgeon toward Experimental Surgery. Roles and Limits of Experimental Surgery
Defraigne, Jean-Olivier ULg

in Acta Chirurgica Belgica (1995), 95(2, Mar-Apr), 113-7

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is ... [more ▼]

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is through research that surgeons can keep some critical mind, essential in their daily activities. However, too often actually, the surgeons abandon research. Two essential reasons explain the phenomenon: on the one hand, the weight of the clinical tasks and on the other hand the complexity of research founded on more and more specialized basic notions. In fact, the part of a surgical investigator must be to form a link between basic research and clinical activities. As such, work in collaboration with motivated basic investigators is cardinal. Also, the success of research depends upon the will of the departments to maintain a research activity, but it meets often with the difficulty in obtaining sufficient research credits. Finally, research can play an essential part in the education of the trainees and partly fill some gaps in their clinical training. [less ▲]

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See detailPET radiopharmaceuticals in Europe : Current use and data relevant for the formulation of summaries of product characteristics (SPCs)
Meyer, G. J.; Waters, S. L.; Coenen, H. H. et al

in European Journal of Nuclear Medicine (1995), 22(12), 1420-1432

The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task ... [more ▼]

The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task group for licensing PET radiopharmaceuticals; this group has surveyed the use of these compounds in Europe by a questionnaire. The number of PET centres that responded to the questionnaire was 26, which included more than 90% of the larger European PET centres. The survey showed that 2-[18F]fluoro-2-deoxyglucose is by far the most important PET radiopharmaceutical with more than 200 applications per week, followed by [15O]water, [15O]carbonmonoxide, [13N]ammonia, [11C]-l-methionine, andl-6-[18F]fluoro-DOPA. More than 25 other PET radiopharmaceuticals are in regular use, however, at rather low application frequencies. The data were used by the European Pharmacopoeia Commission for its priority rating for requesting the formulation of monographs. Since it is likely that group registrations will be issued by authorities for the PET radiopharmaceuticals, relevant data on toxicity and dosimetry for the formulation of summaries of product characteristics have been collected by the task group as well. [less ▲]

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See detailProgress from 1989 to 1992 in understanding the circulation of the Western Mediterranean Sea
Lehucher, P. M.; Beautier, L.; Chartier, M. et al

in Oceanologica Acta (1995), 18(2), 255-271

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the ... [more ▼]

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the physical processes responsible for seasonal and mesoscale variabilities. Observations (in situ and satellite), together with theoretical, physical and numerical models, have been widely used in the course of these studies. Attention has been focused on the dynamics of the northern basin (deep water formation, dynamics of the Northern Mediterranean Current, circulation and shelf/slope interaction in the Balearic Sea) and of the southern basin (Alboran Sea circulation, instabilities of the Algerian Current). The straits dynamics have been studied with particular reference to the Corsica channel. Preliminary runs of a basin-scale circulation model of the Western Mediterranean Sea forced by the straits are also presented. They are shown to be capable of generating a cyclonic circulation in the western basin. [less ▲]

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See detailL'hyperthyroïdie sévère associée à la prise d'amodarone: une urgence chirurgicale
Meurisse, Michel ULg; Hamoir, Etienne ULg; Joris, Jean ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1995), 36(1), 35-45

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du ... [more ▼]

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du traitement par amiodarone, elles peuvent survenir aussi bien chez des sujets porteurs de thyroïdopathies méconnues ou négligées au moment de l'induction du traitement, que chez des patients apparemment indemnes de toute pathologie thyroïdienne pré-existante. Le traitement médical conservateur est le plus souvent inefficace. Dans ces cas, il convient de poser sans hésitation, l'indication d'une thyroïdectomie la plus radicale possible. Ce rapport traite de l'évolution post-opératoire spectaculaire et favorable de 13 cas consécutifs de thyréotoxicose sévère associée à la prise d'amiodarone. La validité de l'approche chirurgicale repose sur la correction rapide et définitive de l'état toxique après exérèse glandulaire. La morbidité quasi nulle liée au geste chirurgical est la seule alternative thérapeutique antithyroïdienne existante qui permette de poursuivre un traitement par amiodarone lorsque celui-ci est indiqué pour contrôler une arytmie menaçante [less ▲]

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See detailNucleotide sequence of the bovine P53 tumor-suppressor cDNA.
Dequiedt, Franck ULg; Willems, Luc ULg; Burny, A. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1995), 5(4),

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See detailA microscopic study of barium titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1995), 164

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See detailBlues & African-American Literature. The Devil's Music in Novels of Nella Larsen,Gayl Jones and Toni Morrison. An Approach
Sacré, Robert ULg

in International Jazz Archives Journal (1995), vol.1(no.3), 93-106

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See detailBovine respiratory disease complex : an european perspective
Lekeux, Pierre ULg

in Bovine Practitioner (1995), 29

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune ... [more ▼]

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune status; its environment, e.g., changes in food, temperature and humidity that lead to stress; and the presence of infectious agents, e.g., bacteria, viruses and mycoplasmas. The syndrome, in a method preferred by the author, can be classified into four grades; Grade 1, subclinical disease; Grade 2, compensated clinical disease (at this stage, the inflammatory reaction generated tends to limit the impact of the disease on the animal); Grade 3, noncompensated clinical disease (at this stage, the inflammatory reaction is excessive and must be controlled); and Grade 4, irreversible clinical disease (which threatens the animal's survival). The increase in frequency and economy impact of bovine respiratory disease complex can be correlated with the escalating industrialization of cattle production. In intensive operations, commingling of animals from multiple sources, exposure to many organisms, stress and management practices are all factors that can lead to disease. The predisposition of cattle, especially beef calves, to respiratory problems is related to their lack of functional pulmonary hardiness. Selection of breeds that demonstrate adequate pulmonary function and sufficient ventilatory reserve may help in the control of the bovine respiratory disease complex, but this approach is difficult to implement and slow to produce results. Prophylactic measures, including vaccination programs and modifying management practices to reduce stress, also have a place in preventing the bovine respiratory disease complex. Unfortunately, these measures are not always easy to put into operation and cannot completely eradicate the problem. Therapeutic strategies to minimize the economy impact of the syndrome include use of appropriate antibacterial therapy, modulation of the pulmonary inflammatory reaction and correction of mechanical disorders. [less ▲]

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See detailThrombospondin modulates human breast adenocarcinoma cell adhesion to human vascular endothelial cells.
Incardona, F.; Lewalle, J. M.; Morandi, V. et al

in Cancer Research (1995), 55(1), 166-73

hrombospondin (TSP), a M(r) 450,000 cytoadhesive glycoprotein, has been shown to potentiate tumor cell metastasis in mice by a mechanism that involves the hemostatic system of the host. In this study, the ... [more ▼]

hrombospondin (TSP), a M(r) 450,000 cytoadhesive glycoprotein, has been shown to potentiate tumor cell metastasis in mice by a mechanism that involves the hemostatic system of the host. In this study, the potential involvement of TSP in the interaction of human mammary adenocarcinoma MCF-7 cells with human umbilical vein endothelial cells (HUVECs) in culture was investigated. Using an ELISA, preconfluent HUVECs synthesized 100-fold more TSP than did MCF-7 cells during 24 h of culture (20 versus 0.2 microgram/10(6) cells). Confocal microscopy localized TSP within intercellular junctions between aggregated MCF-7 cells in suspension. On adherent cells, TSP exhibited a patchy distribution both on the cell surface and in the cytosol. In HUVECs, TSP strongly stained the perinuclear space and was also found in association with cytoskeletal microfibrils. Flow cytometric analysis indicated the presence of a large number of unoccupied receptors for TSP on MCF-7 cells. Binding studies using [125I]TSP demonstrated the presence of 1.6 x 10(6) sites/cell with an apparent Kd of 28 nM. Attachment of radiolabeled MCF-7 cells to a TSP-coated substrate and to HUVEC monolayers was inhibited in the presence of a polyclonal antibody to TSP (10 micrograms/ml) or increasing concentrations (1-10 micrograms/ml) of soluble TSP. Neither nonimmune IgG nor the cell adhesion peptide Gly-Arg-Gly-Asp-Ser (100 micrograms/ml) inhibited these interactions. Inhibition was also observed with heparin (10 micrograms/ml), suggesting the participation of TSP heparin-binding domain(s) and heparin-like molecules. In the presence of an excess of soluble TSP or anti-TSP antibody, MCF-7 cells did not form aggregates in suspension and preformed aggregates were readily dissociated by the addition of soluble TSP. These results indicate that mammary adenocarcinoma cells use TSP to form aggregates and to attach to human endothelial cells. These interactions may have physiological implications during the hematogenous spread of tumor cells. [less ▲]

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See detailStatistical and Non-statistical Reactions in Energy Selected Fluoromethane Ions.
Weitzel, K.-M.; Güthe, F.; Mähnert, J. et al

in Chemical Physics (1995), 201

The unimolécular reactions of the fluoromethane ion have been investigated by the threshold photoelectron photoion coincidence technique (TPIPECO). The breakdown curves have been measured in the energy ... [more ▼]

The unimolécular reactions of the fluoromethane ion have been investigated by the threshold photoelectron photoion coincidence technique (TPIPECO). The breakdown curves have been measured in the energy range between the adiabatic ionization potential of 12.53 eV and 21 eV. In this enery range the formation of the CH2F+, CHF+, CH2+, CH3+, and CF+ fragment ions is observed. The appearance energies (AE) for these ions at 300K are 13.2, 13.91, 13.93, 14.51 and <17.7 eV respectively. The 0K threshold energy for the formation of CH2F+ ions is 13.37 eV. Two different pathways for the unimolecular reaction of the fluoromethane ion can be distinguished.The reaction proceeding through the electronic ground state of the ion is entirely statistical. In contrast to this the reaction occurring through the first electronic excited state shows non-statistical behaviour. The two pathways are distinguished via the kinetic energy released in the respective dissociation channels. While all thermodynamically allowed reaction channels are observed on the ion ground state potential, the first excited state seems to decay predominantly by F loss reaction. [less ▲]

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See detailDepistage des neoplasies endocriniennes multiples de type 1 (NEM 1). Reflexion du Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1).
Cougard, P.; Calender, A.; Carnaille, B. et al

in Annales de Chirurgie (1995), 49(6), 500-506

The "Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1 ... [more ▼]

The "Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1). The objectives of this group are to define diagnostic and therapeutic protocols and to carry out genetic research on NEM1. The first aim of physicians is to recognize the syndrome and to determine the appropriate screening especially into two circumstances: 1 degree In case of isolated and sporadic glandular disease -i-e-parathyroid glands, endocrine pancreas, antehypophysis, adrenal glands and neuroendocrine tumors? 2 degrees In case of very high probability of NEM 1 syndrome? This paper answers these two questions, based on the analysis of the first 150 cases collected by the GENEM 1. [less ▲]

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See detailLa disparition de l'absorption
Kefer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1995)

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See detailAccroissement des exportations agricoles et sécurité alimentaire au Viêt-nam
Lebailly, Philippe ULg; Burny, Philippe ULg

in Economies et sociétés. Série Développement agro-alimentaire, A.G. (1995), 22(3-4), 361-371

La rénovation des politiques et des méthodes d'action à l'égard de l'agriculture a permis au Viêt-nam de conforter sa position de troisième exportateur mondial de riz. Néanmoins la situation semble moins ... [more ▼]

La rénovation des politiques et des méthodes d'action à l'égard de l'agriculture a permis au Viêt-nam de conforter sa position de troisième exportateur mondial de riz. Néanmoins la situation semble moins favorable qu'il n'y paraît. Le marché international du riz est caractérisé par des prix bas et par une forte concurrence entre pays exportateurs. En outre, le marché est réduit et instable. Il s'ensuit que le Viêt-nam, proche de l'autosuffisance, peut tantôt être importateur tantôt exportateur de riz selon les performances enregistrées par les riziculteurs. Cet article analyse les perspectives qui sont actuellement offertes au Viêt-nam en matière de sécurité alimentaire en relation avec l'adoption d'une politique agricole qui encourage l'accroissement des exportations de riz. [less ▲]

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See detailSuivi de la saison des pluies 1991-1992 en Afrique équatoriale à l'aide des indicateurs Météosat "occurrences des nuages à sommet froid et températures de brillance maximum de surface
Kalombo, K.; Lahuec, J. P.; Erpicum, Michel ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailBronchial hyperresponsiveness in active coke-oven workers.
Corhay, Jean-Louis ULg; Bury, Thierry ULg; Louis, Renaud ULg et al

in Archives of Public Health (1995), 53

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See detailImmunohistochemical identification of varicella-zoster virus gene 63-encoded protein (IE63) and late (gE) protein on smears and cutaneous biopsies: implications for diagnostic use.
Nikkels, Arjen ULg; Debrus, S.; Sadzot-Delvaux, Catherine ULg et al

in Journal of Medical Virology (1995), 47(4), 342-7

Early and specific recognition of varicella zoster virus (VZV) infection is of vital concern in immunocompromised patients. The aim of this study was to compare the diagnostic accuracy of histochemical ... [more ▼]

Early and specific recognition of varicella zoster virus (VZV) infection is of vital concern in immunocompromised patients. The aim of this study was to compare the diagnostic accuracy of histochemical and immunohistochemical identification of the VZV ORF63 encoded protein (IE63) and of the VZV late protein gE on smears and formalin-fixed paraffin-embedded skin sections taken from lesions clinically diagnosed as varicella (n = 15) and herpes zoster (n = 51). Microscopic examinations of Tzanck smears and skin sections yielded a diagnostic accuracy of Herpesviridae infections in 66.7% (10/15) and 92.3% (12/13) of varicella, and 74.4% (29/39) and 87.8% (43/49) of herpes zoster, respectively. Immunohistochemistry applied to varicella provided a type-specific virus diagnostic accuracy of 86.7% (13/15; IE63) and 100% (15/15; gE) on smears, and of 92.3% for both VZV proteins on skin sections. In herpes zoster, the diagnostic accuracy of immunohistochemistry reached 92.3% (36/39; IE63) and 94.9% (37/39; gE) on smears, and 91.7% (44/48; IE63) and 91.8% (45/49; gE) on skin sections. These findings indicate that the immunohistochemical detection of IE63 and gE on both smears and skin sections yields a higher specificity and sensitivity than standard microscopic assessments. [less ▲]

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See detailBanques de donnees sur les pesticides et l'environnement: outils precieux pour l'information et la promotion d'un usage correct des pesticides.
Schiffers, Bruno ULg; Cooper, J. F.; Copin, A. et al

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30(4), 319-338

La Convention de Lomé contient un certain nombre de dispositions traitant directement des pesticides, de la lutte intégrée (IPM), de l'environnement et du développement. L'article 40 spécifie que la ... [more ▼]

La Convention de Lomé contient un certain nombre de dispositions traitant directement des pesticides, de la lutte intégrée (IPM), de l'environnement et du développement. L'article 40 spécifie que la Communauté européenne devra fournir toutes les informations disponibles sur les pesticides en vue d'aider les États ACT à promouvoir un usage correct et sans risques de ceux-ci. Le problème le plus immédiat est le manque d'information. [less ▲]

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See detailFinite-amplitude regimes of the short-wave Marangoni-Benard convective instability.
Colinet, Pierre; Legros, Jean-Claude; Kamotani, Y. et al

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 52(3), 2603-2616

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See detailParticle fluxes over a Mediterranean seagrass bed: a one-year sediment trap experiment
Dauby, Patrick ULg; Bale, A. J.; Bloomer, N. et al

in Marine Ecology. Progress Series (1995), 126

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See detailPiracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis
Peuvot, J.; Schanck, A.; Deleers, M. et al

in Biochemical Pharmacology (1995), 50(8), 1129-34

Piracetam, Nootropil (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the ... [more ▼]

Piracetam, Nootropil (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the organization of model phospholipid membranes. 31P NMR data show that the drug induces a structural modification in liposomes made of phosphatidylcholine and phosphatidylethanolamine. Our conformational analysis results have allowed the interpretation of the effect of piracetam on these model membranes: the specific interaction between the drug molecules and the phosphate headgroups induces a new organization of the lipids favouring formation of mobile drug-phospholipid complexes that exhibit an isotropic-type signal in the 31P NMR spectra. [less ▲]

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See detailLes aliments industriels chez le chien: caractéristiques et utilisation dans différents états physiologiques
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1995), 139(5), 309-316

Commercial dog food is more and more frequently used as sole diet. The present review characterizes the different types of commercial diets. Principles of bioenergetic allow the calculation of energy ... [more ▼]

Commercial dog food is more and more frequently used as sole diet. The present review characterizes the different types of commercial diets. Principles of bioenergetic allow the calculation of energy density using a prediction equation. Energy requirements are also calculated. Practical use of industrial dog food are illustrated for growing pups, dogs at maintenance or in reproduction. [less ▲]

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See detailArt (de l'affiche) et pouvoir
Duchesne, Jean-Patrick ULg

in Art&Fact (1995), 14

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See detailRecommendations for the registration of new chemical entities used in the prevention and treatment of osteoporosis
Reginster, Jean-Yves ULg; Compston, JE; Jones, EA et al

in Calcified Tissue International (1995), 57

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See detailEffects of an enriched environment on subsequent fear reactions of lambs and their mothers.
Vandenheede, Marc ULg; Bouissou, Marie-France

in Applied Animal Behaviour Science (1995), 44

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See detailPrediction Of The Antigenic Sites Of The Cystic-Fibrosis Transmembrane Conductance Regulator Protein By Molecular Modeling
Gallet, X.; Benhabiles, N.; Lewin, M. et al

in Protein Engineering (1995), 8(8), 829-34

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and ... [more ▼]

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and valuable antibodies have been raised [Muller et al. (1990) J. Gen. Virol., 71, 2709-2717]. We have improved the modelling approach to allow us to predict epitopes from the primary sequences of the cystic fibrosis transmembrane conductance regulator. The procedure involves searching for fragments of primary sequences likely to make amphipathic secondary structures, which are hydrophilic enough to be at the surface of the folded protein and thus accessible to antibodies. Amphipathic helices were predicted using the methods of Berzofsky, Eisenberg and Jahnig. Their hydrophobic-hydrophilic interface was calculated and drawn, and used to predict the orientation of the helices at the surface of the native protein. Amino acids involved in turns were selected using the algorithm of Eisenberg. Tertiary structures were calculated using 'FOLDING', a software developed by R. Brasseur for the prediction of small protein structures [Brasseur (1995) J. Mol. Graphics, in press]. We selected sequences that folded as turns with at least five protruding polar residues. One important property of antibodies is selectivity. To optimize the selectivity of the raised antibodies, each sequence was screened for similarity (FASTA) to the protein sequence from several databanks. Ubiquitous sequences were discarded. This approach led to the identification of 13 potential epitopes in the cystic fibrosis transmembrane conductance regulator: seven helices and six loops. [less ▲]

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See detailUse of shelter by grazing bulls: effect of climatic factors
Vandenheede, Marc ULg; Nicks, Baudouin ULg; Sheri, R. et al

in Animal Science (1995), 60

The time spent under a shelter by eight grazing fattening bulls of the Belgian Blue breed in each of 3 years consecutively for a total of 48 days was recorded using a time-lapse recorder with infrared ... [more ▼]

The time spent under a shelter by eight grazing fattening bulls of the Belgian Blue breed in each of 3 years consecutively for a total of 48 days was recorded using a time-lapse recorder with infrared illumination. During one grazing period, data were collected over 35 days (experiment 1). Observations were divided into 166 h with rain (20%) and 674 h without precipitation (80%). The average occupation rates were 15.4 (s.e. 29.1)% for the hours with rain and 4.5 (s.e. 14.8)% for the hours without precipitation (P < 0.001). The effect of intensity and duration of rain on the occupation rate was significant from 0.4 l/m(2) or from 2 h. Experiment 2 (13 days of observation) examined the influence of temperature and solar radiation on the use of shelter. The occupation rates were 21 (s.e. 23)% during the daylight hours (07.00 to 19.00 h), 6 (s.e. 8)% during the night (19.00 to 07.00 h) and 14 (s.e. 14)% during a 24-h period. The occupation rate between 07.00 and 19.00 h was significantly correlated to the mean daily temperature (r = 0.75), the maximum daily temperature (r = 0.86) and the direct solar radiation time (r = 0.60). When the maximum daily temperature exceeded 20 degrees C, the use of the shelter increased from 10 to 49% of the daylight hours. There was no significant difference between the live-weight gains of animals from the observed group and those of other bulls on an adjacent pasture without shelter. Nevertheless, these observations suggest that a shelter may improve the welfare of grazing cattle. [less ▲]

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See detailComposition n'est pas raison? Une contrefaçon liégeoise de la Théorie de l'impôt de Mirabeau (1761)
Droixhe, Daniel ULg

in De Gulden Passer = Le compas d'or (1995), 73

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See detailL'hypothyroidie subclinique.
Moreau, L.; Beckers, Albert ULg

in Revue Médicale de Liège (1995), 50(4), 171-4

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie ... [more ▼]

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie affectant surtout les personnes âgées est justifié par l'existence de troubles du bilan lipidique, de goitres et de perturbations neuropsychologiques. Celui-ci repose sur l'administration de lévothyroxine à dose minimale pour normaliser la TSH [less ▲]

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See detailRectovaginal septum, endometriosis or adenomyosis: laparoscopic management in a series of 231 patients.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise et al

in Human Reproduction (1995), 10(3), 630-5

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases ... [more ▼]

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases. In three cases, the bowel lumen was entered. No other peri-operative complications were observed. Three cases of urinary retention were reported. The nodule resection resulted in considerable pain relief. Histologically, the rectovaginal nodule was similar to an adenomyoma. Indeed it was a circumscribed nodular aggregate of smooth muscle and endometrial glands. This form of disease must be considered as a specific disease which originates from the Mullerian rests present in the rectovaginal septum and we suggest that it be called 'rectovaginal adenomyosis'. [less ▲]

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See detailAssessment of lipoxygenase activity in seed extracts from 35 plant species
Fauconnier, Marie-Laure ULg; Vanzeveren, E.; Marlier, Michel et al

in Grasas y Aceites (1995), 46(1), 6-10

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several ... [more ▼]

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several species of Vigna (V. unguiculata, V. radiata and V. mungo) and one of Trifolium exhibit stronger lipoxygenase activity than soybean enzyme extracts. The pH-activity relationship was also established for 4 very active samples. GCMS analysis revealed equal amounts of 9- and 13 hydroperoxides of linoleic acid In these seed extracts, indicating no enzyme positional specificity. [less ▲]

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See detailPyoverdine-mediated uptake of iron in Pseudomonas putida BTP1 : involvement of a 100 KD IROMP.
Delfosse, Ph; Ongena, Marc ULg; Jacques, Ph et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995), 103(B39),

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See detailCabergoline in prolactinomen.
Abs, R.; Verhaert, G.; Demez, Pierre ULg et al

in Tijdschrift voor Geneeskunde (1995), 51

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See detailViolence et justice
Steinmetz, Rudy ULg

in Avancées (1995)

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See detailVenous Allografts for Critical Limb Ischaemia
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1995), 95(1, Jan-Feb), 14-20

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level ... [more ▼]

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level. Recently, there is renewed interest in the use of preserved venous allografts as an alternate conduit in patients with threatened ischaemic limbs. From 1991 to 1993, the authors revascularized 12 ischaemic limbs with venous allografts (10 preserved at 4 degrees C, 2 Varivas grafts). The indication for operation was rest pain in five patients and tissue necrosis in seven. Nine patients had one or more previous ipsilateral revascularizations. The at 4 degrees C preserved venous allografts were conserved for a near period of 2 months. In only half (5/10) of the cases ABO isocompatibility could be respected. Distal anastomosis was always below the knee. In 6 patients, the anastomosis was at tibial level. There was one rupture of a Varivas graft on the fifth postoperative day, necessitating ligation of the graft and subsequent amputation. All other grafts remained patent for a mean period of 10.6 months. Actually, 6 grafts are still open. Most patients were given aspirin. Only three patients were under oral coumarin anticoagulation in an effort to prevent early graft failure. The limb salvage rate is 67% (8/12) (mean follow-up of 13 months). The authors discuss the clinical experience with venous allografts as published in recent literature. Use of venous allografts for arterial reconstruction in humans was met with limited success so far. The one year patency approximates 50%. Venous allografts progress in an ineluctable way to a fibrous conduit.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailInverse Modulation of Intraepithelial Langerhans' Cells and Stromal Macrophage/Dendrocyte Populations in Human Papillomavirus-Associated Squamous Intraepithelial Lesions of the Cervix
Al-Saleh, Walid; Delvenne, Philippe ULg; Arrese Estrada, Jorge ULg et al

in Virchows Archiv : An International Journal of Pathology (1995), 427(1), 41-8

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal ... [more ▼]

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal macrophages/dendrocytes by immunohistochemistry using anti-S100, -L1, -CD68 and -factor XIIIa antibodies. Human papillomavirus (HPV) detection was performed in all cases by using first a mixture of DNA probes for 14 HPV types commonly found in anogenital biopsies at low stringency conditions (Tm -40 degrees C) and by reanalyzing the tissues at high stringency (Tm -10 degrees C) with HPV 6/11, 16/18 and 31/33/35 biotinylated probe cocktails and individual digoxigenin-labelled probes. SILs and metaplastic tissues were significantly associated with a depletion of S100-positive intraepithelial Langerhans' cells when compared with normal epithelium. In contrast, there was a significant increase in L1-positive stromal macrophages in SIL biopsies compared with normal or metaplastic cervix. A significantly higher density of CD68-positive macrophages was also observed in high-grade SILs compared with normal or metaplastic biopsies and with low-grade SILs. The density of factor XIIIa-positive dendrocytes was found to be higher in SILs compared with metaplastic tissues and in high-grade SILs when compared with normal cervical biopsies. No specific relationship was found between the densities of these cells and the HPV type detected in SILs separated into low grade and high grade. The significance of this inverse modulation of intraepithelial Langerhans' cells and stromal macrophages/dendrocytes in normal and SIL biopsies is discussed in relation to HPV infection and malignant transformation. [less ▲]

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See detailApplication des transects pluviométriques spatio-temporels annuels à l’ensemble du territoire sahélien.
Ozer, Pierre ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

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See detailViability of cloned bovine embryos after one or two cycles of nuclear transfer and in vitro culture
Ectors, Fabien ULg; Delval, Alain; Smith, Lawrence et al

in Theriogenology (1995), 44

We described an exclusively in vitro procedure for cloning and recloning bovine embryos. Embryos obtained by IVM/IVF/IVC developed to the morula stage were used as blastomere donors in cunjunction with ... [more ▼]

We described an exclusively in vitro procedure for cloning and recloning bovine embryos. Embryos obtained by IVM/IVF/IVC developed to the morula stage were used as blastomere donors in cunjunction with IVM recipient oocytes. Reconstructed embryos were developed in vitro in co-culture using bovine oviductal epithelial cells. The resulting morulae were used as donors for recloning under the same experimental conditions. No significant difference was observed between cloning and recloning in terms of development (rates of blastocysts: 12.9 versus 14.9%), in the number of nuclei per blastocyst (63.8 versus 49.1), or in pregnancy rates (35.7 versus 33.3%). The high variability observed between replicates and the correlation between results in first and second cycle nuclear transfer may suggest an inherant potential of individual donor embryos to support development by cloning [less ▲]

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See detail3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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