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See detailIdentification of the perosamine synthetase gene of Brucella melitensis 16M and involvement of lipopolysaccharide O side chain in Brucella survival in mice and in macrophages.
Godfroid, F.; Taminiau, Bernard ULg; DANESE, Isabelle ULg et al

in Infection and Immunity (1998), 66(11), 5485-93

Brucella organisms are facultative intracellular bacteria that may infect many species of animals as well as humans. The smooth lipopolysaccharide (S-LPS) has been reported to be an important virulence ... [more ▼]

Brucella organisms are facultative intracellular bacteria that may infect many species of animals as well as humans. The smooth lipopolysaccharide (S-LPS) has been reported to be an important virulence factor of these organisms, but the genetic basis of expression of the S-LPS O antigen has not yet been described. Likewise, the role of the O side chain of S-LPS in the survival of Brucella has not been clearly defined. A mini-Tn5 transposon mutant library of Brucella melitensis 16M was screened by enzyme-linked immunosorbent assay (ELISA) with monoclonal antibodies (MAbs) directed against the O side chain of Brucella. One mutant, designated B3B2, failed to express any O side chain as confirmed by ELISA, Western blot analysis, and colony coloration with crystal violet. Nucleotide sequence analysis demonstrated that the transposon disrupted an open reading frame with significant homology to the putative perosamine synthetase genes of Vibrio cholerae O1 and Escherichia coli O157:H7. The low G+C content of this DNA region suggests that this gene may have originated from a species other than a Brucella sp. The survival of B. melitensis mutant strain B3B2 in the mouse model and in bovine macrophages was examined. The results suggested that S-LPS or, more precisely, its O side chain is essential for survival in mice but not in macrophages. [less ▲]

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See detailFonction et signification de l'image égyptienne
Laboury, Dimitri ULg

in Bulletin de la Classe des Beaux-Arts de l'Académie Royale de Belgique, 6e série (1998), IX

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See detailApercu des techniques d'analyse conformationnelle des macromolecules biologiques.
Deleu, Magali ULg; Wathelet, Bernard ULg; Paquot, Michel ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(4), 234-247

Outline of conformational analysis techniques of the biological macromolecules. This paper presents a synthesis of thevarious methods of conformational analysis of biological macromolecules usually quoted ... [more ▼]

Outline of conformational analysis techniques of the biological macromolecules. This paper presents a synthesis of thevarious methods of conformational analysis of biological macromolecules usually quoted in the literature. The generalprinciples as well as the limitations and advantages of various experimental techniques are exposed. These techniques shouldnot be regarded as competitors but as complementary. To finish, a chapter is devoted to the presentation of a theoretical tool,the molecular modeling. [less ▲]

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See detailIsotope splitting of the zero-phonon line of Fe2+ in cubic III-V semiconductors
Colignon, David ULg; Mailleux, Éric; Kartheuser, Eduard ULg et al

in Solid State Communications (1998), 105(4), 205-209

A theoretical study of the isotopic-mass dependence of the internal transitions of Fe2+ at a cation site in a cubic zinc-blende semiconductor is presented. The model used is based on crystal-field theory ... [more ▼]

A theoretical study of the isotopic-mass dependence of the internal transitions of Fe2+ at a cation site in a cubic zinc-blende semiconductor is presented. The model used is based on crystal-field theory and includes the spin-orbit interaction and a weak dynamic Jahn-Teller coupling between the (5) Gamma(5) excited manifold of Fe2+ and a local vibrational mode (LVM) of Gamma(5) symmetry. The mass dependence of the LVM frequency is described, in the harmonic approximation, within two different limits: the rigid-cage model and a molecular model. In the rigid-cage model, the Fe2+ ion undergoes a displacement but the rest of the lattice is fixed. In this case, a simple M-1/2 dependence of the frequency is obtained and the Jahn-Teller energy, E-JT, is independent of the mass. In the molecular model, the four nearest neighbors of the magnetic ion are allowed to move and the LVM then behaves as the Gamma(5) mode of a MX4 tetrahedral molecule leading to a more complicated dependence of the frequency on the isotopic mass and to a mass-dependence of E-JT. The theoretical results obtained with these two models are compared with the observed isotopic shifts of the zero-phonon lines in InP:Fe and GaP:Fe corresponding to an optical transition between the vibronic Gamma(1) ground state and the lowest Gamma(5) state originating from the (5) Gamma(5) excited orbital multiplet. A prediction of the isotopic shifts of the zero-phonon line in GaAs:Fe is also presented. (C) 1997 Elsevier Science Ltd. [less ▲]

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See detailL'enseignement de la chimie aux étudiants du secondaire qui se destinent à l'université: Trois heures de chimie valent mieux qu'une
Cornélis, André ULg; Cahay, René ULg; Leyh, Bernard ULg

in Chimie Nouvelle (1998), 16

The major importance of a high quality chemistry education in secondary schools is highlighted by the analysis of the results of a procedure developed at the University of Liège to help the students ... [more ▼]

The major importance of a high quality chemistry education in secondary schools is highlighted by the analysis of the results of a procedure developed at the University of Liège to help the students starting their university education, to evaluate their level of basic chemistry competences and to improve them if necessary. It turns out that students who followed three weekly periods of chemistry per week in the secondary school are clearly favoured compared to those who had only one period. These discrepancies show up not only on the starting competence level but also on the progress realized during the remediation step. The starting competence level influences also the strategy chosen by the student for his/her individual remediation. [less ▲]

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See detailEtude contrastive de la notion temps/aspect dans les langues indo-européennes
Mouton, Charles ULg

in Slavica Gandensia (1998), (25/1), 29-41

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See detailLes territoires biogéographiques de la Belgique.
De Sloover, Jacques; Dufrêne, Marc ULg

in Acta geographica Lovaniensia (1998), 37

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See detailAutonomy to plant growth regulators and gene expression in periwinkle cultures in vitro
Droual, Anne-Marie; Hamdi, Said; Creche, Joel et al

in Journal of Plant Physiology (1998), 153(5-6), 623-630

To better understand the effect of habituation on gene expression in plant cells, we have compared the accumulation of specific mRNAs encoding respectively two proline-rich proteins, a chaperone protein ... [more ▼]

To better understand the effect of habituation on gene expression in plant cells, we have compared the accumulation of specific mRNAs encoding respectively two proline-rich proteins, a chaperone protein and three enzymes linking primary and secondary metabolisms in two models of in vitro culture of periwinkle. These models consisted of two couples of a 2,4-dichlorophenoxyacetic acid-dependent/2,4-dichlorophenoxyacetic acid independent line in which autonomy to auxin and cytokinin was obtained either through habituation or through transformation with the isopentenyltransferase gene from Agrobacterium tumefaciens. Results showed that gene expression was modified by plant growth regulator autonomy but differently according to the type of autonomy: only the gene encoding a hydroxyproline-rich glycoprotein was regulated similarly in both PGR-independent lines. On the other hand, PGR autonomy did not lead to total insensitivity to exogenously-applied PGRs, and the two PGR autonomous lines did not accumulate indole alkaloids for different reasons. [less ▲]

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See detailTraumatismes crâniens et épilepsie
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Percentile (1998), 3(1), 29-32

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See detailAntibody formation and plasma profiles of insulin-like growth factor-I (IGF-I) and IGF-binding proteins in growing heifers after sustained-release exogenous BST administration
Bertozzi, Carlo; Portetelle, Daniel ULg; Massart, Serge et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 45

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See detailA revision of the names of foliicolous lichenized fungi published by Batista and co-workers between 1960 and 1975
Lücking, Robert; Sérusiaux, Emmanuël ULg; Maia, Leonor C. et al

in Lichenologist (1998), 30

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See detailQuel est votre diagnostic radiographique? Un cas de myélome multiple chez un chien.
Godefroid, T.; Sauders, J.; Peeters, Dominique ULg

in Annales de Médecine Vétérinaire (1998), 142

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See detailCooper pair-like systems at high temperature and their role on fluctuations near the critical temperature
Ausloos, Marcel ULg; Dorbolo, Stéphane ULg

in International Journal of Modern Physics B : Condensed Matter Physics, Statistical Physics, Applied Physics (1998), 12

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See detailAssociation of fibroblastoid features with the invasive phenotype in human bronchial cancer cell lines
Polette, M.; Gilles, Christine ULg; de Bentzmann, S. et al

in Clinical & Experimental Metastasis (1998), 16(2), 105-12

The acquisition of a metastatic phenotype by epithelial cells implicates a series of changes altering their differentiation, their overall behavior and morphology. In the present study, we have examined ... [more ▼]

The acquisition of a metastatic phenotype by epithelial cells implicates a series of changes altering their differentiation, their overall behavior and morphology. In the present study, we have examined the relationships between the cellular morphology, E-cadherin expression, matrix metalloproteinases expression and in vitro invasive properties in two human bronchial immortalized cell lines. The (16HBE14o-) cell line which did not show any invasive abilities in the Boyden chamber assay displayed a typical epithelial morphology in monolayer, expressed high levels of E-cadherin and synthesized neither MMP-2 and MT1-MMP nor vimentin. In contrast, the BZR cell line which was highly invasive displayed a more elongated phenotype in monolayer, did not produce E-cadherin but expressed vimentin, MMP-2 and MT1-MMP. Our data therefore suggest that the metastatic progression of broncho-pulmonary cancer cells results in a cellular dedifferentiation and the gain of some mesenchymal attributes (loss of E-cadherin and expression of vimentin) associated with enhanced degradative properties (expression of metalloproteinases) [less ▲]

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See detailNouvelles datations du Trou Al'Wesse dans le contexte régional
Otte, Marcel ULg; Collin, Fernand ULg; Miller, Rebecca ULg et al

in Notae Praehistoricae (1998), 18

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See detailMercury porosimetry applied to low density xerogels; relation between structure and mechanical properties
Pirard, René ULg; Heinrichs, Benoît ULg; Van Cantfort, Olivier et al

in Journal of Sol-Gel Science and Technology (1998), 13(1-3), 335-339

Samples of low density xerogels were submitted to mercury porosimetry at pressures up to 200 MPa. These samples show an unusual behavior: they are first crushed by the isostatic mercury pressure without ... [more ▼]

Samples of low density xerogels were submitted to mercury porosimetry at pressures up to 200 MPa. These samples show an unusual behavior: they are first crushed by the isostatic mercury pressure without mercury intrusion and are then intruded by the mercury above a certain pressure. This transition allows the easy determination of the one constant found in the buckling model that is used to interpret the crushing part of the mercury porosimetry experiment. The relation between this constant and the structure of the xerogels determined by TEM and nitrogen adsorption is discussed. [less ▲]

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See detailElectroencéphalographie du prématuré et du nouveau-né à terme
Dubru, Jean-Marie ULg; Leroy, Patricia; Misson, Jean-Paul ULg

in Percentile (1998), 3

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See detailBlock and random copolymers of ε-caprolactone
Duda, Andrzej; Biela, Tadeusz; Libiszowski, Jan et al

in Polymer Degradation & Stability (1998), 59(1-3), 215-222

Conditions of the living homopolymerization of epsilon-caprolactone (CL), lactides (LA), and of the homo-oligomerization of gamma-butyrolactone (BL) are briefly described. Then block and random ... [more ▼]

Conditions of the living homopolymerization of epsilon-caprolactone (CL), lactides (LA), and of the homo-oligomerization of gamma-butyrolactone (BL) are briefly described. Then block and random copolymerizations of CL with LA are shortly reviewed. The microstructure of the resulting copolyesters in relation to some peculiarities of these processes is discussed in more detail. It is also shown that the otherwise 'non-polymerizable' BL does form high molecular weight copolymers with CL, containing up to 50 mol% repeating units derived from BL. Their molecular weight is controlled by the concentrations of the consumed comonomers and the starting concentration of the initiator. NMR and DSC data indicate the random structure of copolymers. TGA traces of the BL/CL copolymers show that the presence of the gamma-oxybutyryl repeating units randomly distributed within the poly(CL) chains improves the thermal stability of the latter. [less ▲]

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See detailThe diversity, structure and regulation of beta-lactamases.
Philippon, A; Dusart, Jean; Joris, Bernard ULg et al

in Cellular and Molecular Life Sciences : CMLS (1998), 54(4), 341-6

beta-Lactamase production is responsible for the appearance of a large number of pathogenic bacterial strains exhibiting a high degree of resistance to beta-lactam antibiotics. A large number of enzymes ... [more ▼]

beta-Lactamase production is responsible for the appearance of a large number of pathogenic bacterial strains exhibiting a high degree of resistance to beta-lactam antibiotics. A large number of enzymes have been described with very diverse primary structures and catalytic profiles. Nevertheless, all known three-dimensional structures of active-site serine beta-lactamases exhibit a high degree of similarity with apparently equivalent chemical functionalities in the same strategic positions. These groups might not, however, play identical roles in the various classes of enzymes. Structural data have also been recently obtained for the zinc metallo-beta-lactamases, but the detailed catalytic mechanisms might also differ widely, depending on the enzyme studied. Similarly, the induction of the synthesis of beta-lactamases is now better understood, but many questions remain to be answered. [less ▲]

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See detailRégulation transcriptionnelle du gène de la prolactine humaine
Muller, Marc ULg; Berwaer, Monique; Caccavelli, Laure et al

in Medecine Sciences : M/S (1998), 14(580-587),

Le gène humain de la prolactine (hPRL) est exprimé essentiellement par l'antéhypophyse. L'analyse des éléments régulateurs de la transcription sur plus de 5 000 bases en amont du site de début de ... [more ▼]

Le gène humain de la prolactine (hPRL) est exprimé essentiellement par l'antéhypophyse. L'analyse des éléments régulateurs de la transcription sur plus de 5 000 bases en amont du site de début de transcription a montré l'importance du contrôle par le facteur de transcription Pit-1, spécifique de l'hypophyse, à côté de facteurs ubiquistes. Des hormones modulent l'expression du gène hPRL, transmettant leur signal par les voies intracellulaires de l'AMP cyclique et du calcium, relayées au niveau du promoteur proximal (-250/+1) essentiellement par les facteurs de transcription Pit-1 et AP-1. Les récepteurs nucléaires contrôlent aussi en partie la transcription de hPRL: le récepteur des oestrogènes l'active en se liant aux éléments de réponse distaux ; les récepteurs nucléaires des hormones thyroïdiennes et des glucocorticoïdes la répriment en interférant respectivement avec la fonction activatrice de AP-1 et de Pit-1. [less ▲]

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See detailApplications de la stimulation magnetique corticale.
MAERTENS DE NOORDHOUT, Alain ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (1998), 28(1), 9-30

In the last decade, a new electrophysiological tool has become available since the development of painless magnetic stimulators able to activate the primary motor cortex and the motor roots in conscious ... [more ▼]

In the last decade, a new electrophysiological tool has become available since the development of painless magnetic stimulators able to activate the primary motor cortex and the motor roots in conscious man. Therefore, it became possible to measure the conduction time within fast-conducting central motor pathways by substracting from the total latency of muscle responses elicited by cortical stimuli the conduction time in peripheral nerves. This technique proved sensitive enough to illustrate early abnormalities of central motor conduction in various neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, cervical spondylotic myelopathy, degenerative ataxias or hereditary spastic paraplegias. When recorded early after stroke, motor evoked potentials are also a valuable tool to predict functional outcome. They can also illustrate subtle pathophysiological disturbances in diseases where there is no direct involvement of central motor pathways such as Parkinson's disease, dystonia or epilepsy. Magnetic cortical stimulation also offers unique opportunities to explore intracerebral inhibitory and excitatory circuits and mechanisms of brain plasticity. The recent development of rapid rate stimulators also enables functional studies of non-motor cerebral regions such as visual or frontal cortices. Moreover, rapid rate stimulation seems useful in the treatment of drug-resistant depression but the safety of this procedure, particularly with regard to the production of seizures or kindling, remains to be fully documented. [less ▲]

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See detailVascular endothelial growth factor (VEGF) in endometriosis.
Donnez, Jacques; Smoes, Pierre; Gillerot, Stéphane et al

in Human Reproduction (1998), 13(6), 1686-90

Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the peritoneal layer, the establishment ... [more ▼]

Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the peritoneal layer, the establishment of a new blood supply is essential for the survival of the endometrial implant and development of endometriosis. From the known angiogenic factors, vascular endothelial growth factor (VEGF) has emerged as a pivotally important regulator of normal angiogenesis and pathological neovascularization. The VEGF protein was evaluated immunohistochemically in the eutopic endometrium of 10 women without endometriosis (group I) at laparoscopy and the eutopic endometrium and peritoneal endometriotic lesions of 43 women with endometriosis (group II). VEGF histological scores were 9.7 +/- 4.3 and 4.0 +/- 2.6 respectively in the epithelium and stroma of the eutopic endometrium of group I women, and 10.3 +/- 2.3 and 3.6 +/- 2.3 respectively in women of group II. In red lesions, the VEGF scores were 11.1 +/- 3.0 in the epithelium and 5.1 +/- 3.0 in the stroma, and in black lesions were 8.6 +/- 2.7 and 1.6 +/- 1.6, respectively. Significantly lower values were observed in black lesions as compared with eutopic endometrium and red lesions, the values of which were similar. Scores were also evaluated according to the phase of the cycle. In eutopic as well as ectopic endometrium, no significant cyclic variations were observed throughout the cycle. However, VEGF content was found to be higher in the eutopic glandular epithelium of women with endometriosis during the late secretory phase, possibly suggesting a more likely tendency to implant. In contrast, significantly higher VEGF content was noted in red lesions as compared with black lesions. During all phases of the cycle, the VEGF content in stromal cells of red lesions was higher than in black lesions. Similarities in VEGF content were observed in the glandular epithelium of the eutopic endometrium of women with endometriosis and red lesions, suggesting that endometriosis probably arises from the peritoneal seeding of viable endometrial cells during retrograde menstruation and that red lesions can be considered as the first stage of implantation. After the attachment phase, the high VEGF levels could provoke an increase in the subperitoneal vascular network and facilitate implantation and viability in the retroperitoneal space. Lower VEGF levels in black lesions explain the decrease in both stromal vascularization, followed by fibrosis and inactivation of the implant. [less ▲]

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See detailSuperconducting properties of natural and artificial grain boundaries in bulk melt-textured YBCO
Vanderbemden, Philippe ULg; Bradley, A. D.; Doyle, R. A. et al

in Physica C: Superconductivity (1998), 302(4), 257-270

A range of experimental techniques have been used to characterize melt-processed YBa2Cu3O7-d samples containing single-grain boundaries. Both natural high-angle boundaries, which sometimes appear during ... [more ▼]

A range of experimental techniques have been used to characterize melt-processed YBa2Cu3O7-d samples containing single-grain boundaries. Both natural high-angle boundaries, which sometimes appear during the grain growth process, and artificial low-angle boundaries, obtained by joining two single domains, have been investigated. Electrical resistivity, current-voltage characteristics, magnetic moment measurements and Hall probe mapping techniques have been employed to investigate the boundaries. Results are compared with the properties of single domain material (i.e., containing no grain boundary) for which T-c approximate to 89 K and J(c)parallel to ab (77 K, 1 T) > 10^4 A/cm(2). Resistance measurements across all the grain boundaries show a stronger dependence on current and magnetic field than that measured within the grains and exhibit a pronounced resistive 'tail'. The I-V curves obtained for the high-angle natural grain boundary are sharp and differ from the rounded I-V curves which are characteristic of single-grains. Field mapping measurements used to evaluate the critical current anisotropy are in agreement with magnetisation measurements. The limitations of this technique for investigating boundaries are discussed. It was found that current anisotropy can conceal a weak link between two grains, leading to a false indication of single-grain behaviour. Artificially engineered boundaries are shown to have significant potential for applications in high fields at 77 K. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEffects of two 1-year calcium and vitamin D3 treatments on bone remodeling markers and femoral bone density in elderly women
DEROISY, Rita ULg; Collette, Julien ULg; Chevalier, T et al

in Current Therapeutic Research (1998), 59(12), 850-862

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See detailPotentiation of dopamine agonists-induced oral stereotypies by GABA-A agonists in mice : differentiation of dopamine uptake inhibitors
Tirelli, Ezio ULg; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1998), 284

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See detailHow the *H-particle* unravels the quark dynamics
Stancu, Floarea ULg; Pepin, S.; Glozman, L Ya

in Physical Review. D : Particles and Fields (1998), D57

It is shown that the short-range part of the Goldstone boson exchange interaction between the constituent quarks, which explains baryon spectroscopy and the short-range repulsion in the NN system, induces ... [more ▼]

It is shown that the short-range part of the Goldstone boson exchange interaction between the constituent quarks, which explains baryon spectroscopy and the short-range repulsion in the NN system, induces a strong short-range repulsion in the flavour-singlet state of the $S=-2$ system with $J^P=0^+$. This suggests that a deeply bound H-particle should not exist. We compare our approach with other models employing different hyperfine interactions between quarks in the nonperturbative regime of QCD. [less ▲]

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See detailAn association exists between bovine herpesvirus-4 seropositivity and abortion in cows.
Czaplicki, G.; Thiry, Etienne ULg

in Preventive Veterinary Medicine (1998), 33(1-4), 235-40

The prevalence of cattle seropositive to bovine herpesvirus-4 (BHV-4) is high in Belgium. In Belgian farms, clinical signs associated with BHV-4 infection essentially involve the genital tract and consist ... [more ▼]

The prevalence of cattle seropositive to bovine herpesvirus-4 (BHV-4) is high in Belgium. In Belgian farms, clinical signs associated with BHV-4 infection essentially involve the genital tract and consist mainly of postpartum metritis or metroperitonitis. The role of BHV-4 in abortion has not been definitively demonstrated but epidemiological and experimental facts suggest its involvement. A seroepidemiological investigation was therefore conducted as a case-control study to compare the seroprevalences of BHV-4 infections in the aborted-cow population and in a randomly selected control group in the province of Liege (Belgium). The seroprevalence (17.2%) in aborted cows was significantly higher than that of the control group (10.0%). The odds ratio (OR) was 1.87 (1.06 < 3.30). BHV-4 infection is therefore considered as a risk factor for abortion in cows. [less ▲]

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See detailGenerating random percolation clusters.
Bogaert, Jan ULg; Impens, I

in Applied Mathematics and Computation (1998), 91(2-3), 197-208

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See detailError estimation based on a new principle of projection and reconstruction
Remacle, J.-F.; Geuzaine, Christophe ULg; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (1998), 34(5), 3264--3267

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See detailStudies on the value of incorporating the effect of dominance in genetic evaluations of dairy cattle, beef cattle and swine
Misztal, I.; Varona, L.; Culbertson, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2

Nonadditive genetic effects are currently ignored in national genetic evaluations of farm animals because of ignorance of the level of dominance variance for traits of interest and the difficult ... [more ▼]

Nonadditive genetic effects are currently ignored in national genetic evaluations of farm animals because of ignorance of the level of dominance variance for traits of interest and the difficult computational problems involved. Potential gains from including the effects of dominance in genetic evaluations include “purification” of additive values and availability of predictions of specific combining abilities for each pair of prospective parents. This study focused on making evaluation with dominance effects feasible computationally and on ascertaining benefits of such an evaluation for dairy cattle, beef cattle, and swine. Using iteration on data, computing costs for evaluation with dominance effects included costs could be less than twice expensive as with only an additive model. With Method Â, variance components could be estimated for problems involving up to 10 millions equations. Dominance effects accounted for up to 10% of phenotypic variance; estimates were larger for growth traits. As a percentage of additive variance, the estimate of dominance variance reached 78% for 21-d litter weight of swine and 47% for post weaning weight of beef cattle. When dominance effects are ignored, additive evaluations are “contaminated”; effects are greatest for evaluations of dams in a single large family. These changes in ranking were important for dairy cattle, especially for dams of full-sibs, but were less important for swine. Specific combining abilities cannot be included in sire evaluations and need to be computed separately for each set of parents. The predictions of specific combining abilities could be used in computerized mating programs via the Internet. Gains from including the dominance effect in genetic evaluations would be moderate but would outweigh expenditures to produce those evaluations. [less ▲]

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See detailNew estimate of the carbon sink strength of EU forests integrating flux measurements, field surveys, and space observations: 0.17-0.35 Gt(C)
Martin, Philippe; Valentini, R.; Jacques, M. et al

in AMBIO : A Journal of the Human Environment (1998), 27(7), 582-584

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See detailChirurgie vasculaire chez l'octogénaire
VAN DAMME, Hendrik ULg; SMITZ, Simon ULg; LARBUISSON, Robert ULg et al

in Revue Médicale de Liège (1998), 53(3), 149-57

The prevalence of peripheral vascular disease increases with aging of the population. About 8% of the octogenarians present significant carotid artery stenosis, about 4% have an abdominal aortic anneurysm ... [more ▼]

The prevalence of peripheral vascular disease increases with aging of the population. About 8% of the octogenarians present significant carotid artery stenosis, about 4% have an abdominal aortic anneurysm of 40 mm or more, and 6% suffer critical limb ischemia. Carotid endarterectomy in octogenarians is a valuable tool for stroke prevention, only if the combined perioperative stroke-mortality rate is lower than 3%. Operating an abdominal aneurysm of 50 mm or more in octogenarians is characterized by an operative mortality that is higher compared to that observed in a younger patient group (4.7% vs 2.7%). Aneurysm-surgery remains nevertheless justified, since it is the only way to prevent the evolution to rupture, that is almost fatal. Limb salvage surgery should always be considered for an 80-years patient with critical limb ischemia, since readaptation after major limb-amputation is not evident for octogenarians. An extensive review of literature is presented concerning vascular aging and results of carotid surgery, aneurysm repair and lower limb revascularization in octogenarians. The authors report their own recent experience with carotid surgery and aneurysm repair in patients aged 80 years or older. [less ▲]

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See detailHet hoogst haalbare
Spinoy, Erik ULg

in Nieuw Wereld Tijdschrift (1998), 5(4), 74-75

This is a review of Dutch translations of Hölderlin's poetry, made by the Dutch writer and critic Ad den Besten.

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See detailValidation of impulse oscillometry in Friesian and Blue Belgian calves with respect to changes in extrathoracic upper airway resistance
Reinhold, Petra; Smith, H.-J.; Close, Roland et al

in Research in Veterinary Science (1998), 65

Impulse oscillometry (IOS) was compared with conventional pulmonary function techniques (using oesophageal balloon and airflow measurements). Healthy Friesian (FR) and Blue Belgian (BB) calves were ... [more ▼]

Impulse oscillometry (IOS) was compared with conventional pulmonary function techniques (using oesophageal balloon and airflow measurements). Healthy Friesian (FR) and Blue Belgian (BB) calves were examined in different conditions of extrathoracic airway resistance (physiological and vertical head position). Higher resistance values were detected in BB calves compared with FR calves with both conventional and forced oscillation techniques in both head positions. Upper airway narrowing was characterised by increasing resistance values without changes in frequency dependence. Measuring input impedance in animals using a face mask, a considerable capacitive shunt of the upper airways (including the capacitive components of the mask) has to be taken into account. Even if the absolute value of this capacitive component is constant, its influence on the measurement results increases with growing frequency and with an increase in upper airway resistance. In conclusion, (1) impulse oscillometry is sensitive to upper airway resistance changes and (2) face mask capacitance is important and has frequency dependent effects on the respiratory impedance. [less ▲]

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See detailContact between deformable solids, the fully coupled approach
Habraken, Anne ULg; Cescotto, Serge ULg

in Mathematical & Computer Modelling (1998), 28(4-8), 153-169

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See detailRadiative transition probabilities for forbidden lines in singly ionized cobalt (Co II)
Quinet, Pascal ULg

in Astronomy and Astrophysics. Supplement Series (1998), 129

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See detailEndocardite végétante dans l’espèce équine : revue de littérature à partir de 2 cas cliniques
Amory, Hélène ULg; Christmann; Cassart, Dominique ULg et al

in Annales de Médecine Vétérinaire (1998), 144

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See detailPotentiels urbains et îlots de chaleur
Cornélis, Bernard ULg; Binard, Marc ULg; Nadasdi, Istvan

in Publications de l'Association Internationale de Climatologie (1998), 10

The present contribution aims at answering in a quantitative way the question: is there a relationship between urban heat island and urban potential ? If such a relationship exits, it tries to quantify it ... [more ▼]

The present contribution aims at answering in a quantitative way the question: is there a relationship between urban heat island and urban potential ? If such a relationship exits, it tries to quantify it and to answer the following questions : - would the potential model allow the representation of the heat island phenomenon ? - If so, in which conditions ? [less ▲]

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See detailCompte-rendu de A. Gasse : Catalogue des ostraca littéraires de Deir el-Médina
Winand, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1998), 73(146), 72-75

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See detailCumulation and injury determination of the European Community in antidumping cases
Tharakan, P. K. M.; Greenaway, David; Tharakan, Joseph ULg

in Weltwirtschaftliches Archiv (1998)

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See detailHeavy-flavour pentaquarks in a chiral constituent quark model
Genovese, M.; Richard, J. M.; Stancu, Floarea ULg et al

in Physics Letters B (1998), B425

Within the chiral constituent quark model of Glozman and Riska, we discuss the stability of heavy pentaquarks, i.e. hadrons containing four light quarks and a heavy antiquark. The spin-dependent part of ... [more ▼]

Within the chiral constituent quark model of Glozman and Riska, we discuss the stability of heavy pentaquarks, i.e. hadrons containing four light quarks and a heavy antiquark. The spin-dependent part of the Hamiltonian is dominated by the short-range part of the Goldstone-boson-exchange interaction. We find that these systems are not bound, having an energy above the lowest dissociation threshold into a baryon and a meson. [less ▲]

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See detailDopamine D4 receptors, a new opportunity for research on schizophrenia
Liégeois, Jean-François ULg; Eyrolles, L.; Bruhwyler, J. et al

in Current Medicinal Chemistry (1998), 5

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See detailSpéléothèmes des karsts siliceux du Niger et du Cameroun
Willems, Luc ULg; Compère, Philippe ULg; Sponholz, Barbara et al

in Géosciences au Cameroun & collection Géocam (1998), 1

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See detailLes chimioradiothérapies dans les cancers du col utérin
Maingon, P; COUCKE, Philippe ULg; Haie-Meder, C et al

in Cancer Radiotherapie (1998), 2

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See detailFloating Population and Migration in China. The Impact of Economic Reforms
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (1998), Vol. XVI

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See detailCaractérisation phénotypique et génotypique de la virulence potentielle de souches d'Escherichia coli bovines isolées en Algérie
Mellata, M.; Bakour, R.; Jacquemin, E. et al

in Annales de Médecine Vétérinaire (1998), 142

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See detailLe logement des vaches laitières
Nicks, Baudouin ULg

in Annales de Médecine Vétérinaire (1998), 142(6), 413-416

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See detailQualitative and quantitative evaluation of bisindole usambarane alkaloids in Strychnos usambarensis roots by high performance liquid chromatography diode-array
Frederich, Michel ULg; Tits, Monique ULg; Angenot, Luc ULg

in Phytochemical Analysis (1998), 9(2), 63-66

A high performance liquid chromatographic method for the simultaneous determination of bisindole usambarane alkaloids from the roots of Strychnos usambarensis using a diode-array detector is proposed, The ... [more ▼]

A high performance liquid chromatographic method for the simultaneous determination of bisindole usambarane alkaloids from the roots of Strychnos usambarensis using a diode-array detector is proposed, The system, consisting of a RP-8 Select B column and a linear gradient elution with acetonitrile and acetate buffer allowed the separation of all the alkaloids in 20 min, Usambarensine was found to be the major tertiary alkaloid present in the roots, In order to demonstrate the possibility of quantifying the bisindole alkaloids in crude roots extracts, the quantitative evaluation of 3',4'-dihydrousambarensine, usambarensine and N-b-methylusambarensine was carried out. (C) 1998 John Wiley & Sons, Ltd. [less ▲]

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See detailLa notion de 'mêmes parties', condition de la litispendance communautaire
Boularbah, Hakim ULg

in Journal des Tribunaux (1998)

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See detailVisages de l'étrangeté et formes du rêve
Gauthier, Jean-Marie ULg

in Revue Belge de Psychanalyse (1998), 33

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See detailPrediction Of Epitopes And Production Of Monoclonal Antibodies Against Gastric H,K-Atpase
Irnaten, M.; Gallet, X.; Festy, F. et al

in Protein Engineering (1998), 11(10), 949-55

Monoclonal antibodies (mAbs) were produced against gastric H,K-ATPase using a theoretical and experimental strategy based on prediction of linear epitopes by molecular modelling followed by production of ... [more ▼]

Monoclonal antibodies (mAbs) were produced against gastric H,K-ATPase using a theoretical and experimental strategy based on prediction of linear epitopes by molecular modelling followed by production of anti-peptide antibodies. By analysing the alpha subunit sequence, we predicted several epitopes corresponding to amino acids K519-L533, E543-Y553 and S786-L798 and produced monoclonal antibodies HK519, HK543 and HK786. All three react against gastric H,K-ATPase in RaLISA, immunohistochemistry and Western blots demonstrating that they recognize the native and the SDS-denatured ionic pump and that the epitopes are located at the surface of the native ATPase. Antibody Kd are in the range 6-10x10(-8) M. Monoclonal antibody HK519 is a competitive inhibitor of ATP, in agreement with ATP binding to K519. Neither mAb 543, nor mAb 786 inhibit the ATPase activity. Monoclonal antibody 95111, whose epitope is mapped between residues C529 and E561, competes with mAb HK543 but not with the other two. We suggest that the 95111 epitope is overlapping or very close to the HK543-553 sequence. Induction of E1 conformer by binding FITC to K519 increases the number of mAb 95111 and mAb HK543 epitopes but not that of mAb 786, supporting the fact that the fragment E543-Y553 changes accessibility, maybe during the E1-E2 transconformation. [less ▲]

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See detailToward a general theory of the age in ocean modelling
Delhez, Eric ULg; Campin, Jean-Michel; Hirst, Anthony et al

in Ocean Modelling (1998), 1

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See detailLes principales plantes toxiques chez le cheval
Delaunois, A.; Demoulin, V.; Gustin, Pascal ULg

in Annales de Médecine Vétérinaire (1998), 142

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See detailQualité protéique des aliments. Technique de dosage des acides aminés.
Wathelet, Bernard ULg

in Probio-Revue (1998), 1-2

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See detailLes institutions gériatriques entre rationalisation et subjectivation
Vrancken, Didier ULg

in Prévenir (1998), 35(2), 41-48

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See detailDynamique de défense du nid chez Symphodus ocellatus (Forsskål, 1775), poisson labridé méditerranéen. II. Comportements agressifs du mâle territorial nidificateur envers des mollusques gastéropodes
Ylieff, Marc ULg; Michel, Christian ULg; Voss, Jacques

in Cahiers d'Ethologie (1998), 18(1), 39-52

This field research examines aggressive behaviour towards gasteropod molluscs in nesting territorial male of Symphodus ocellatus. This behaviour is useful for brood and nest defense. Four questions ... [more ▼]

This field research examines aggressive behaviour towards gasteropod molluscs in nesting territorial male of Symphodus ocellatus. This behaviour is useful for brood and nest defense. Four questions involving Symphodus ocellatus towards gasteropod molluscs were investigated. Questions of interest were: (1) selective cleaning of the nest according to possible predation danger of molluscs on the eggs, (2) visual recognition of natural mollusc from artificially coloured lure, (3) colours discriminating abilities by the visual system and, more generally (4) the importance of territorial male investment in nest defense; this role could ensure a successful reproduction of the species. Our observations and experimentations (coloured dummies) allow us to conclude that in Symphodus ocellatus, nesting territorial males clean every time their nest, any gasteropod mollusc species whatever; that they have sufficient knowledge of their usual biological environment to be able to discriminate a gasteropod mollusc from a dummy; that the organ of perception used for social recognition is the visual channel constituted by a neural system competent to perceive colours finely , a special quality which support the theory about the use of one preferential colour (red for S.ocellatus) for visual communication; that fry protection insured by territorial male, a task guided by his visual system, is necessary considering dangers from some gasteropod molluscs living in his habitat. [less ▲]

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See detailOiseau, d'où viens-tu?
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (1998), 31(8), 20-22

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See detailCytokinins and ethylene stimulate indole alkaloid accumulation in cell suspension cultures of Catharanthus roseus by two distinct mechanisms
Yahia, Abdelouahab; Kevers, Claire ULg; Gaspar, Thomas ULg et al

in Plant Science (1998), 133(1), 9-15

The interactions between cytokinins and ethylene on alkaloid accumulation in a periwinkle cell line have been examined. It was found that (a) either exogenously-applied cytokinins or ethylene (the latter ... [more ▼]

The interactions between cytokinins and ethylene on alkaloid accumulation in a periwinkle cell line have been examined. It was found that (a) either exogenously-applied cytokinins or ethylene (the latter through ethephon degradation) greatly enhanced ajmalicine accumulation in cells subcultured in a 2,4-dichlorophenoxyacetic acid-free medium; (b) the enhancing effect of cytokinin was not mediated by enhancement of endogenous ethylene production contrary to what is found in some plant models, (c) the responses to exogenous cytokinin and ethylene were additive and showed a different pattern of expression. It may be concluded that cytokinin and ethylene can up-regulate the alkaloid production in a periwinkle cells through independent pathways when added exogenously to the cultures. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailCorticosteroid Treatment in Active Crohn's Disease
Belaiche, Jacques ULg; Louis, Edouard ULg

in Acta Gastro-Enterologica Belgica (1998), 61(2, Apr-Jun), 153-7

Despite recent improvements in the management of Crohn's disease, steroids are still the most efficacious treatment in flare ups of the disease. However they have significant side effects and are only ... [more ▼]

Despite recent improvements in the management of Crohn's disease, steroids are still the most efficacious treatment in flare ups of the disease. However they have significant side effects and are only effective in the short term. There is no consensus regarding initial dose or duration of corticotherapy. With 1 mg/Kg a day of oral prednisolone given for 3 to 7 weeks, 92% of the patients achieve clinical remission. Topical acting oral corticosteroids such as budesonide seem to represent an important therapeutic advance due to their better tolerance. The promising results of budesonide in mild and moderate flare ups need to be confirmed and its indication in severe disease beside high dose prednisolone has to be clarified. [less ▲]

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See detailPrise en compte des variations de la perméabilité et du coefficient d’emmagasinement spécifique dans les simulations hydrogéologiques en milieux argileux saturés
Dassargues, Alain ULg

in Bulletin de la Société Géologique de France (1998), 169(5), 665-673

It is well known that the consolidation of compressible silt-clay geological layers induces a decrease in porosity. Consequently, the hydraulic conductivity and the compressibility of the medium are also ... [more ▼]

It is well known that the consolidation of compressible silt-clay geological layers induces a decrease in porosity. Consequently, the hydraulic conductivity and the compressibility of the medium are also decreased and the hydrodynamic conditions changed. A full coupling between the groundwater flow and the subsidence processes must be taken into account with non-linear parameters. In saturated conditions, the specific storage coefficient is directly related to the volume compressibility of the medium; its evolution depends on the rheological law chosen to describe the consolidation of the medium. For the hydraulic conductivity, the choice of the variation law is more difficult and should be made in each case as a function of the experimental data and measurements. Comparisons are made between computations with constant and varying parameters. The computed pore pressures are strongly affected, automatically inducing the major differences in the calculated subsidences. Different laws of non-linearity for the hydraulic conductivity are tested on a practical case taken from the study of the land subsidence in Shanghai. This subsidence was induced by heavy groundwater withdrawal. [less ▲]

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See detailTumeurs Cérébrales chez l'Enfant : Expérience du Département Universitaire de Pédiatrie de Liège
Senterre, Thibault ULg; Leroy, Patricia; Misson, Jean-Paul ULg

in Percentile (1998), 3(1), 26-28

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See detailRecommendations for the registration of drugs used in the treatment of rheumatoid arthritis
Lemmel, EM; Reid, DM; Nuki, G et al

in British Journal of Rheumatology (1998), 37

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See detailFunctional brain imaging of human sleep
Maquet, Pierre ULg; Phillips, Christophe ULg

in Journal of Sleep Research (1998), 7(Suppl. 1), 42-47

This paper presents an overview of the contribution of functional brain mapping to the study of human sleep. Early studies were essentially successful in describing the variations of the global level of ... [more ▼]

This paper presents an overview of the contribution of functional brain mapping to the study of human sleep. Early studies were essentially successful in describing the variations of the global level of cerebral metabolism. More recently, regional distribution of cerebral blood flow was reported. The results suggest that the permissive and executive processes of slow wave sleep and REM sleep are similar in humans and in animals. They also show cortical blood flow distributions specific to each sleep stage. The cellular mechanisms underlying the involvement of these cortical areas in sleep are not yet precisely known. They should be looked for by further investigations in animals. Future research in functional neuroimaging will attempt to explore functional and, hopefully, effective connectivity between cerebral areas involved in sleep processes. This final goal will probably require the co-registration of two or more brain imaging techniques to precisely describe the spatio-temporal course of neuronal interactions occurring during sleep. [less ▲]

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See detailGround-based infrared solar spectroscopic measurements of carbon monoxide during 1994 Measurement of Air Pollution From Space flights
Pougatchev, N. S.; Jones, N. B.; Connor, B. J. et al

in Journal Of Geophysical Research. Atmospheres (1998), 103(D15), 19317-19325

Results of the comparison of carbon monoxide ground-based infrared solar spectroscopic measurements with data obtained during 1994 Measurement of Air Pollution From Space (MAPS) flights are presented ... [more ▼]

Results of the comparison of carbon monoxide ground-based infrared solar spectroscopic measurements with data obtained during 1994 Measurement of Air Pollution From Space (MAPS) flights are presented. Spectroscopic measurements were performed correlatively with April and October MAPS flights by nine research groups from Belgium, Canada, Germany, Japan, New Zealand, Russia, and the United States. Characterization of the techniques and error analysis were performed. The role of the CO a priori profile used in the retrieval was estimated. In most cases an agreement between spectroscopic and MAPS data is within estimated MAPS accuracy of +/-10%. [less ▲]

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See detailScale relativity and quantization of the solar system - Orbit quantization of the planet's satellites
Hermann, Raphaël ULg; Schumacher, G.; Guyard, R.

in Astronomy and Astrophysics (1998), 335(1), 281-286

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present ... [more ▼]

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present paper we show that one more class of objects of the solar system satisfy the rule of quantization, this class including the main satellites and rings of the outer planets. We also give a classification of the satellites by rank, showing that one can predict the existence of certain orbits that are not occupied, or whose objects are not yet discovered. [less ▲]

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See detailHémoglobine glyquée : le temps de la standardisation est venu
Gillery, P.; Bordas-Fonfrède, M.; Chapelle, Jean-Paul ULg et al

in Annales de Biologie Clinique (1998), 56(3), 249-51

Le dosage de l'hémoglobine glyquée est utilisé en pratique quotidienne pour le suivi à long terme de l'équilibre glycémique chez les patients atteints de diabète sucré. De nombreuses techniques ont été ... [more ▼]

Le dosage de l'hémoglobine glyquée est utilisé en pratique quotidienne pour le suivi à long terme de l'équilibre glycémique chez les patients atteints de diabète sucré. De nombreuses techniques ont été décrites depuis une vingtaine d'années, fondées sur différents principes, et dosant différentes formes glyquées de l'hémoglobine. Cela explique que, bien que ce test très informatif soit utilisé au quotidien par les diabétologues, il existe encore une grande disparité des résultats d'un laboratoire à l'autre, rendant leur comparaison impossible. [less ▲]

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See detailLes thiazolidinediones : quel avenir dans le traitement du diabète de type 2 ?
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (1998), 56

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See detailMating behaviour and male mate choice in Tribolium castaneum (Coleoptera, Tenebrionidae).
Arnaud, L.; Haubruge, Eric ULg

in Behaviour (1998), 136(1),

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See detailInduction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury.
Hopkins, D. A.; Plumier, Jean-Christophe ULg; Currie, R. W.

in Experimental Neurology (1998), 153(2), 173-83

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular ... [more ▼]

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular metabolic stress. In this study, we examined the distribution of Hsp27 in the rat medulla oblongata by means of immunohistochemistry after the vagus nerve was cut or crushed. After vagal injury, rats were allowed to survive for 6, 12, 24 h, 2, 4, 7, 10, 14, 30, or 90 days. Vagus nerve lesions resulted in a time-dependent up-regulation of Hsp27 in vagal motor and nodose ganglion sensory neurons that expressed Hsp27 constitutively and de novo induction in neurons that did not express Hsp27 constitutively. In the dorsal motor nucleus of the vagus nerve (DMV) and nucleus ambiguus, the levels of Hsp27 in motor neurons were elevated within 24 h of injury and persisted for up to 90 days. Vagal afferents to the nucleus of the tractus solitarius (NTS) and area postrema showed increases in Hsp27 levels within 4 days that were still present 90 days postinjury. In addition, increases in Hsp27 staining of axons in the NTS and DMV suggest that vagus nerve injury resulted in sprouting of afferent axons and spread into areas of the dorsal vagal complex not normally innervated by the vagus. Our observations are consistent with the possibility that Hsp27 plays a role in long-term survival of distinct subpopulations of injured vagal motor and sensory neurons. [less ▲]

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See detailAnemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production.
Corazza, Francis; Beguin, Yves ULg; Bergmann, Pierre et al

in Blood (1998), 92(5), 1793-8

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect ... [more ▼]

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). To further elucidate the pathophysiology of anemia in children with cancer, we measured serum soluble transferrin receptor (sTfR), a quantitative marker of erythropoiesis, and serum EPO at time of diagnosis and during chemotherapy in children suffering from solid tumor or leukemia. We determined serum EPO in 111 children (55 leukemia, 56 solid tumors) at time of diagnosis. In the last 44 patients (23 leukemia and 21 solid tumors), sTfR levels were also measured. Serum EPO together with sTfR levels were also determined in 60 children receiving chemotherapy (29 leukemia, 31 solid tumors). These results were compared with those obtained from appropriate control groups. In all patients, we found a highly significant correlation between the logarithm of EPO (log[EPO]) and the hemoglobin (Hb) level. In all subsets of patients, sTfR levels were inappropriately low for the degree of anemia. Neither leukemic nor solid tumor groups showed a significant inverse relationship between log(sTfR) and the Hb level as would be expected in anemic patients with appropriate marrow response. Thus, in children with cancer, anemia is associated with a decreased total bone marrow erythropoietic activity which, in contrast to what has been reported in anemic cancer adults, is not related to defective EPO production. [less ▲]

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See detailLes élus d'origine étrangère à Bruxelles: une nouvelle étape de la participation politique des populations d'origine immigrée
Martiniello, Marco ULg

in Revue Européenne des Migrations Internationales (1998), 14(2), 123-149

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See detailIn vitro modulation of human gingival keratinocyte migration by minocycline-HCl
Van Heusden, Alain ULg; Nusgens, Betty ULg; Lapière, Charles et al

in Journal of Dental Research (1998), 77

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See detailWiewiorka's view on Multiculturalism: a critique
Martiniello, Marco ULg

in Ethnic and Racial Studies (1998), 21(5), 911-916

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See detailMolecular Structure and Surface Order in Monolayers of Alkanethiols Evidenced by HREELS
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Thin Solid Films (1998), 327-329

Structural characteristics and order within n-alkanethiols, a,q-alkanedithiols and a-cycloalkyl-q-alkanethiols monolayers self-assembled on gold have been investigated using high resolution electron ... [more ▼]

Structural characteristics and order within n-alkanethiols, a,q-alkanedithiols and a-cycloalkyl-q-alkanethiols monolayers self-assembled on gold have been investigated using high resolution electron energy loss spectroscopy (HREELS). The coherent domain sizes have been estimated from the angular distribution of the elastic peak as a function of the nature of the alkane chain and of the immersion time in the thiol solutions. These data have revealed many defects in the organization of the monolayers on evaporated gold substrates. It has been shown that the domains are smaller on Au(100) than on Au(111). [less ▲]

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See detailIn vitro ototoxicity of aminoglycosides and platin derivatives. A semi-automatic assay for sensory hair cell damage in explanted rat organ of corti.
Malgrange, B.; LEFEBVRE, Philippe ULg; van de Water, T.R. et al

in Toxicology in Vitro (1998), 12 (6)

The ototoxic damage that drugs such as neomycin, kanamycin, colistin, cisplatin, transplatin and carboplatin cause on outer and inner hair cells in postnatal day 3 rat cochlear explants was investigated ... [more ▼]

The ototoxic damage that drugs such as neomycin, kanamycin, colistin, cisplatin, transplatin and carboplatin cause on outer and inner hair cells in postnatal day 3 rat cochlear explants was investigated. Phalloidin-fluorescein conjugate-stained stereocilia bundles of sensory hair cells were quantified by video image analysis as a measurement of ototoxic effect. The video image quantification system established dose-response curves for ototoxic drugs (e.g. calculation of an IC50) and allowed comparisons between several ototoxins from the same family. This methodology provided the means to assess the efficacy of otoprotectant agents in preventing ototoxicity. Poly-l-aspartate (10-5M) and poly-l-glutamate (10-5M) protected auditory hair cells from neomycin (10-3M) toxicity while reduced glutathione (10-3M) provided protection against cisplatin (10-4M)-induced hair cell damage. [less ▲]

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See detailAlternative oxidase in the branched mitochondrial respiratory network: an overview on structure, function, regulation, and role.
Sluse, Francis ULg; Jarmuszkiewicz, W.

in Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas (1998), 31

Plants and some other organisms including protists possess a complex branched respiratory network in their mitochondria. Some pathways of this network are not energy-conserving and allow sites of energy ... [more ▼]

Plants and some other organisms including protists possess a complex branched respiratory network in their mitochondria. Some pathways of this network are not energy-conserving and allow sites of energy conservation to be bypassed, leading to a decrease of the energy yield in the cells. It is a challenge to understand the regulation of the partitioning of electrons between the various energy-dissipating and -conserving pathways. This review is focused on the oxidase side of the respiratory chain that presents a cyanide-resistant energy-dissipating alternative oxidase (AOX) besides the cytochrome pathway. The known structural properties of AOX are described including transmembrane topology, dimerization, and active sites. Regulation of the alternative oxidase activity is presented in detail because of its complexity. The alternative oxidase activity is dependent on substrate availability: total ubiquinone concentration and its redox state in the membrane and O2 concentration in the cell. The alternative oxidase activity can be long-term regulated (gene expression) or short-term (post-translational modification, allosteric activation) regulated. Electron distribution (partitioning) between the alternative and cytochrome pathways during steady-state respiration is a crucial measurement to quantitatively analyze the effects of the various levels of regulation of the alternative oxidase. Three approaches are described with their specific domain of application and limitations: kinetic approach, oxygen isotope differential discrimination, and ADP/O method (thermokinetic approach). Lastly, the role of the alternative oxidase in non-thermogenic tissues is discussed in relation to the energy metabolism balance of the cell (supply in reducing equivalents/demand in energy and carbon) and with harmful reactive oxygen species formation. [less ▲]

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See detailNear Infrared Spectroscopy for Non-Invasive Assessment of Intracranial Haemoglobin Oxygenation in an in Vitro Model of the Calf Head
Pringle, John; Art, Tatiana ULg; Lekeux, Pierre ULg

in Research in Veterinary Science (1998), 65(2), 103-109

An in vitro model of the calf head was used to examine the ability of near infrared spectroscopy (NIRS) to non-invasively determine oxygenation events within the calf head. The brains were removed from 16 ... [more ▼]

An in vitro model of the calf head was used to examine the ability of near infrared spectroscopy (NIRS) to non-invasively determine oxygenation events within the calf head. The brains were removed from 16 calf skulls and replaced with oxygenated dilutions of calf blood that had the oxygen progressively decreased from PO2 > 110 mmHg to < 10 mmHg. Appropriate placement of the lighting source and sensor (optodes) was examined, as were the influences of skull thickness and overlying skin of the skull (including colour). The changes in haemaglobin oxygenation in the model calf head, as observed by NIRS, were highly correlated to PO2 changes in all 16 calf skulls examined (mean r2=0.91, range 0.71 to 0.99). There was a trend for optode positioning to achieve optimal NIRS signals over the middle of the frontal bone in a longitudinal axis and with optodes spaced 4 cm apart, but with the large variation between calf heads this was not shown to be significantly different from other sites tested. The presence of skin over the skull had a significant damping effect on the NIRS signal when compared with the bare skull (P<0.01) but it was not possible to detect a difference in this damping effect between black and white coloured skin. All but the two thickest skulls (13 and 14 mm frontal bone thickness) appeared to allow sufficiently strong NIRS signals of changes in haemoglobin oxygenation. This study showed that NIRS can be used for non-invasive study of oxygenation events within the cranial cavity of calves, and established some guidelines and limitations for its use in this species. [less ▲]

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See detailNouveaux traitements immunomodulateurs dans la maladie de Crohn
Louis, Edouard ULg; Belaiche, Jacques ULg

in Médecine et Hygiène (1998), 56

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See detailBisphosphonates and osteoporosis treatment in Italy
Gennari, C; Reginster, Jean-Yves ULg

in Aging Clinical & Experimental Research (1998), 10

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See detailLes minéraux secondaires en relation avec les sulfures de la région de Vielsalm, Belgique
Hatert, Frédéric ULg; Blondieau, Michel; Dehove, José et al

in Bulletin de la Société Royale des Sciences de Liège (1998), 67

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See detailCompte rendu de La circulation des nouvelles au Moyen Age, Paris, 1994
George, Philippe ULg

in Cahiers de Clio (1998)

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See detailSynthesis of Tetraalkyl(Pyrrolidine-2,2-diyl)bisphosphonates and 2,2-Bis(diethoxyphosphoryl)-3,4-dihydro-2H-pyrrole 1-Oxide; ESR Study of Derived Nitroxides
Olive, Gilles ULg; Le Moigne, François; Mercier, Anne et al

in Journal of Organic Chemistry (1998), 63(24), 9095-9099

Synthesis of Tetraalkyl (Pyrrolidine-2,2-diyl)bisphosphonates and 2,2-Bis(diethoxyphosphoryl)-3,4-dihydro-2Hpyrrole 1-Oxide; ESR Study of Derived Nitroxides

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See detailThe production of pro- and anti-inflammatory cytokines in neonates assessed by stimulated whole cord blood culture and by plasma levels at birth.
SEGHAYE, Marie-Christine ULg; Heyl, W.; Grabitz, R. G. et al

in Biology of the Neonate (1998), 73(4), 220-7

The capability of neonates to achieve cytokine balance was evaluated. Production of the pro-inflammatory cytokines TNF alpha and IL-8, of the natural anti-inflammatory cytokine IL10 and of the regulator ... [more ▼]

The capability of neonates to achieve cytokine balance was evaluated. Production of the pro-inflammatory cytokines TNF alpha and IL-8, of the natural anti-inflammatory cytokine IL10 and of the regulator of the acute phase response IL6 was assessed after whole blood stimulation by lipopolysaccharide in cord blood (n = 10), adult volunteers serving as control (n = 17). Additionally, circulating cytokines were determined in cord and in maternal blood immediately after delivery (n = 27, respectively). Significant production of TNF alpha, IL8, IL10 and IL6 was observed in cord blood after lipopolysaccharide stimulation and was similar to cytokine production in adult blood. The plasma concentrations of TNF alpha were significantly higher in cord than in maternal blood, while plasma concentrations of IL10 and IL6 were significantly lower. Our results demonstrate fully developed capability of whole cord blood to synthesize pro- and anti-inflammatory cytokines in response to a pro-inflammatory stimulation in vitro. In vivo, however, higher circulating TNF alpha and lower IL10 and IL6 levels in cord blood suggest that the inflammatory stress associated with normal delivery does not induce detectable anti-inflammatory response in neonates at birth. [less ▲]

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See detailLes aires protégées dans la tourmente. Evolution de la situation de 1990 à 1996
Bouché, Philippe ULg

in Cahiers d'Ethologie (1998), 18(2), 161-174

The Akagera National Park (ANP) and the Volcano National Park (VNP) are the main protected areas in Rwanda. Following civil war that bloodstained the country since 1990, the destiny of these two parks ... [more ▼]

The Akagera National Park (ANP) and the Volcano National Park (VNP) are the main protected areas in Rwanda. Following civil war that bloodstained the country since 1990, the destiny of these two parks diverged. The VNP, dedicated to the conservation of one of the last population of mountain gorillas and of their habitat, recovered somehow the same situation as before the war despite some gorillas were lost. The ANP, on the other hand, has been invaded by large herds of domestic cattle, which resulted in serious injuries at its integrity. It seems that two-thirds of the park are on the way to be sacrificed and will be devoted to human and cattle settlement. The fate of the remaining third is still undecided. About 63 years after the park was created, the golden era of this protected area of international reputation seems close to an end... But it is the conservationists' duty to carry on. [less ▲]

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See detailGrandir en l'an 2000 : les enfants et l'école maternelle
Crahay, Marcel ULg; Hindryckx, Geneviève ULg; Lafontaine, Annette ULg et al

in Point sur la Recherche en Education (Le) (1998), 6

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See detailNumber and relative size of thenar motor units in ALS patients: application of the adapted multiple point stimulation method.
Wang, François-Charles ULg; Delwaide, Paul ULg

in Electroencephalography and Clinical Neurophysiology (1998), 109(1), 36-43

In the present study, the adapted multiple point stimulation (AMPS) method was first applied to median innervated thenar muscles in 22 amyotrophic lateral sclerosis (ALS) patients who did not received any ... [more ▼]

In the present study, the adapted multiple point stimulation (AMPS) method was first applied to median innervated thenar muscles in 22 amyotrophic lateral sclerosis (ALS) patients who did not received any treatment. In all patients, a motor unit number estimate (MUNE) and an average surface-recorded motor unit action potential (S-MUAP) size have been derived even if the denervation was severe; and the results were reproducible. The thenar MUNE was less than the normal lower limit for age in 17 patients, and the mean MUNE (67.1 +/- 90.6) was significantly different from that estimated in control subjects (263.3 +/- 116.8). The mean S-MUAP size in the 22 ALS patients was 352.9 +/- 328.4 microV x ms versus 94.1 +/- 30.3 microV x ms in healthy volunteers. A control AMPS was achieved in 8 patients after 2 and 6 months of a glutamate-release antagonist (riluzole) treatment. The mean loss of motor units, based on control thenar MUNEs realized after 6 months of treatment, was 53%. In conclusion, we propose AMPS as a manageable, reproducible and non-invasive procedure which permits one to quantify peripheral denervation and to appreciate the effectiveness of collateral reinnervation in ALS patients. [less ▲]

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