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See detailCritical points and reaction paths characterization on a potential energy hypersurface
Ramquet, Marie-Noëlle; Dive, Georges ULg; Dehareng, Dominique ULg

in Journal of Chemical Physics (2000), 112(11), 4923-4934

Most of the time, the definitions of minima, saddle points or more generally order p (p=0,...,n) critical points, do not mention the possibility of having zero Hessian eigenvalues. This feature reflects ... [more ▼]

Most of the time, the definitions of minima, saddle points or more generally order p (p=0,...,n) critical points, do not mention the possibility of having zero Hessian eigenvalues. This feature reflects some flatness of the potential energy hypersurface in a special eigendirection which is not often taken into account. Thus, the definitions of critical points are revisited in a more general framework within this context. The concepts of bifurcation points, branching points, and valley ridge inflection points are investigated. New definitions based on the mathematical formulation of the reaction path are given and some of their properties are outlined. (C) 2000 American Institute of Physics. [S0021-9606(00)01110-7]. [less ▲]

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See detailEfficiency measurement, multiple-output technologies and distance functions: with application to European Railways
Coelli, Tim; Perelman, Sergio ULg

in Applied Economics (2000), (32), 1967-1976

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in ... [more ▼]

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in a multiple-output industry using econometric methods one would usually either: (a) aggregate outputs into a single index of output (e.g., total revenue or a multilateral Tornqvist output index); or (b) attempt to model the technology using a dual cost function. The first of these methods require that output prices be observable (and reflect revenue maximising behaviour), while the latter approach requires an assumption of cost-minimising behaviour. There are a number of instances, however, when neither of these requirements are met (the public sector contains many examples). In this study we outline the recently developed distance function solution to the multi-output problem. The method is illustrated using data on European railways. Output-orientated, input-orientated and constant returns to scale distance functions are estimated using corrected ordinary least squares. The distance function estimates are also compared with production function estimates involving aggregate output measures. These comparisons indicate that, for the case of European railways, a production function involving a multilateral Tornqvist output index exhibits substantially less aggregation bias relative to a production function that uses total revenue as a measure of aggregate output. [less ▲]

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See detailPersistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Haematologica (2000), 85(6), 613-8

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve ... [more ▼]

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve clinical outcome. Therefore, we studied the value of (18)F-FDG PET for early evaluation of response in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We studied 28 patients by (18)F-FDG PET after a median of 3 cycles of polychemotherapy. The presence or absence of abnormal (18)F-FDG uptake was correlated to clinical outcome (median follow-up: 17.5 months, range 4-47 months). RESULTS: Five of 28 patients still had increased (18)F-FDG uptake in one or more sites previously shown to be involved by lymphoma at baseline evaluation. Only one of these five patients entered complete remission (CR), whereas among the 23 patients with negative (18)F-FDG PET studies, two died of toxicity during chemotherapy and all the others entered clinical CR (p<0.00001). All five patients with and 7/21 patients without residual abnormal (18)F-FDG uptake relapsed or reprogressed (positive predictive value for relapse: 100%, negative predictive value: 67%). By Kaplan-Meier analysis, progression-free survival (PFS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive patients and 81+/-9% and 62+/-12% for (18)F-FDG PET negative patients (p=0.0001). Overall survival (OS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive and 87+/-7% and 68+/-11% for (18)F-FDG PET negative patients (p<0.0001). INTERPRETATION AND CONCLUSIONS: Persistent tumoral (18)F-FDG uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL. Further studies are warranted to determine whether (18)F-FDG PET has a predictive value independent from conventional prognostic factors. However, the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient. Earlier evaluation after only one cycle of chemotherapy and quantitative analysis might increase the sensitivity of 18F-FDG PET is predicting treatment failure. [less ▲]

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See detailEndometrial laser intrauterine thermotherapy: the first series of 100 patients observed for 1 year
Donnez, Jacques; Polet, Roland; Rabinovitz, Rafi et al

in Fertility and Sterility (2000), 74(4), 791-6

Objective: To describe a new instrument (GyneLase®) that offers a new approach (endometrial laser intrauterine thermal therapy [ELITT]) to treatment of menorrhagia and to evaluate the efficacy of ELITT in ... [more ▼]

Objective: To describe a new instrument (GyneLase®) that offers a new approach (endometrial laser intrauterine thermal therapy [ELITT]) to treatment of menorrhagia and to evaluate the efficacy of ELITT in the management of dysfunctional uterine bleeding. Design: Prospective study. Setting: University hospital. Patient(s): 100 premenopausal women with dysfunctional uterine bleeding were observed for 1 year. Intervention(s): Intrauterine laser thermotherapy with a diode laser. Main Outcome Measurement(s): Amenorrhea rate after 1 year. Result(s): The amenorrhea rate after 1 year of follow-up was 71%, and the rate of amenorrhea/severe hypomenorrhea rate was >90%; these rates are much higher than those in the literature after such procedures as electrosurgery or intrauterine thermal balloon therapy. The ELITT procedure is an inherently safe and simple alternative, providing controlled and effective treatment of the entire endometrium. In contrast to traditional endometrial ablation using a neodymium yttrium-aluminum-garnet laser, the ELITT procedure does not require intensive training or hysteroscopic control; it is also far less risky, because the power used per unit area is 1,000 times lower. Conclusion(s): The ELITT procedure is a new nonhysteroscopic technique for endometrial ablation. The technique is very safe and offers the highest amenorrhea rate to date in the literature. [less ▲]

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See detailMelanoma screening: results of the first one-day campaign in Belgium (‘Melanoma Monday’)
Vandaele, M.; Richert, Bertrand ULg; Van der Endt, J. M. et al

in Journal of the European Academy of Dermatology & Venereology (2000), 14

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a ... [more ▼]

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a media campaign, with more relevant information and the opportunity for free skin inspections. Methods: A ‘Task Force’ organized a media campaign in April 1999 and convinced 65% of the Belgian dermatologists to give up 4 h of their time to do free skin examinations for skin cancer on Monday 26 April 1999; it was called ‘Melanoma Monday’. Results: A total 2767 patients were screened. We found 25 melanomas and suspected 59 basal cell carcinomas. In the following 4 weeks another 141 melanomas were found. These 166 melanomas found in one month represent 15 –20% of the total number of melanomas per year in Belgium. Summary: A media campaign with relevant information combined with screening opportunities can lead to the early detection of melanomas in a large number of patients and can continue to alert people at risk in the following weeks. [less ▲]

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See detailL'analyse de la variance multivariée et l'analyse canonique discriminante : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (2000), (1), 40

This note describes the principles of multivariate analysis of variance and of canonical discriminant analysis. The methods are illustrated by two examples.

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See detailDiscordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.
Twizere, Jean-Claude ULg; Kerkhofs, Pierre; Burny, Arsène et al

in Journal of Virology (2000), 74(21), 9895-902

Bovine leukemia virus (BLV) Tax protein, a transcriptional activator of viral expression, is essential for viral replication in vivo. Tax is believed to be involved in leukemogenesis because of its second ... [more ▼]

Bovine leukemia virus (BLV) Tax protein, a transcriptional activator of viral expression, is essential for viral replication in vivo. Tax is believed to be involved in leukemogenesis because of its second function, immortalization of primary cells in vitro. These activities of Tax can be dissociated on the basis of point mutations within specific regions of the protein. For example, mutation of the phosphorylation sites at serines 106 and 293 abrogates immortalization potential in vitro but maintains transcriptional activity. This type of mutant is thus particularly useful for unraveling the role of Tax immortalization activity during leukemogenesis independently of viral replication. In this report, we describe the biological properties of BLV recombinant proviruses mutated in the Tax phosphorylation sites (BLVTax106+293). Titration of the proviral loads by semiquantitative PCR revealed that the BLV mutants propagated at wild-type levels in vivo. Furthermore, two animals (sheep 480 and 296) infected with BLVTax106+293 developed leukemia or lymphosarcoma after 16 and 36 months, respectively. These periods of time are within the normal range of latencies preceding the onset of pathogenesis induced by wild-type viruses. The phenotype of the mutant-infected cells was characteristic of a B lymphocyte (immunoglobulin M positive) expressing CD11b and CD5 (except at the final stage for the latter marker), a pattern that is typical of wild-type virus-infected target cells. Interestingly, the transformed B lymphocytes from sheep 480 also coexpressed the CD8 marker, a phenotype rarely observed in tumor biopsies from chronic lymphocytic leukemia patients. Finally, direct sequencing of the tax gene demonstrated that the leukemic cells did not harbor revertant proviruses. We conclude that viruses expressing a Tax mutant unable to transform primary cells in culture are still pathogenic in the sheep animal model. Our data thus provide a clear example of the discordant conclusions that can be drawn from in vitro immortalization assays and in vivo experiments. These observations could be of interest for other systems, such as the related human T-cell leukemia virus type 1, which currently lack animal models allowing the study of the leukemogenic process. [less ▲]

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See detailL'antibiothérapie en néonatalogie: mise-au-point
Langhendries, JP; Kalenga, Masendu ULg; Battisti, Oreste ULg et al

in Journal du Pédiatre Belge (2000), 2

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See detailIonic adsorption of ammonium and nitrate on some animal litters and their role in ammonia volatilization
Nimenya, H.; Delaunois, A.; Bloden, Serge ULg et al

in Annals of Zootechnology (2000), 49

Two experiments were carried out to determine the adsorption of ammonium and nitrate on litters (Exp. 1) and the volatilization of ammonia in their presence (Exp. 2). In Exp. 1, glass tubes containing 15 ... [more ▼]

Two experiments were carried out to determine the adsorption of ammonium and nitrate on litters (Exp. 1) and the volatilization of ammonia in their presence (Exp. 2). In Exp. 1, glass tubes containing 15 mi of a buffered solution enriched with NH4Clcalculated as 10.59 mg.l(-1) of NH4+ or KNO3 calculated as 50 mg.l(-1) of NO3- were used. Graded amounts (0 [control], 25, 50, 100 mg) of litters (wheat straw, nax straw (Equi-lin(R)), zeolite (Zeolite Stall Fresh(R)), spruce sawdust and beech sawdust) were added to the tubes which were incubated for 24 h. Ammonium and nitrate concentrations, and pH, were checked on the supernatant. A preliminary experiment was carried out with zeolite to come to an ammonium balance. After adsorption of ammoniumby graded amounts of zeolite, [0 (control), 0.25, 1, 2, 4 g], ammonium balance was assessed after two elutions with 1 N HCl. In Exp. 2, Woulff flasks were used and ammonia was trapped in a solution of 0.1 N HCl. The preliminary experiment showed that the ammonium added and adsorbed by different amounts of zeolite was completely recovered after 2 elutions. All litters, except beech sawdust, were effective in ammonium adsorption. Especially, the straws were required in very small amounts to immobilize the added ammonium or nitrate. Furthermore, with straws the pH value decreased from pH 7.5-7.60 to pH 6.90, and this effect was related to the amounts of material added. For each pH group, ammonia volatilization was significantly decreased (P <0.05) with straw (wheat straw, Equi-lino) as compared with their blank pH group. However, no significant decrease was observed with sawdust (spruce, beech) and zeolite [less ▲]

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See detailLithics in Belgium. Some Current Research Trends
Rots, Veerle ULg; Vermeersch, Pierre

in Lithic Technology (2000), 25(2), 76-79

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See detailTEP et tumeurs endocrines
Rigo, Pierre ULg; Belhocine, Tarik; Hustinx, Roland ULg et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2000), 24(5), 275-282

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les ... [more ▼]

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les tumeurs neuroendocrines, gastroentéropancréatiques et carcinoïdes, sont également analysées. Habituellement, les tumeurs différenciées ayant une faible activité métabolique et proliférative, elles ne fixent que peu le FDG. Dans l'évaluation des tumeurs endocrines, la TEP au FDG n'intervient en général pas en première intention mais elle joue un rôle complémentaire d'autres scintigraphies spécifiques. [less ▲]

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See detailRecension: "Théorie critique du principe général de bonne foi en droit privé"
Kohl, Benoît ULg

in Actualités du Droit (2000)

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See detailMotivations et apports d'une prise en charge ambulatoire pluridisciplinaire de la santé des adolescents
Bourguignon, Jean-Pierre ULg; Grignard, Sophie ULg; Glowacz, Fabienne ULg et al

in Bulletin d'Education du Patient à sa Maladie (2000), 19(3), 126-129

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils ... [more ▼]

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils consultent peu à ce sujet. En particulier, ils évoquent rarement les aspects psychosociaux des problèmes auxquels ils sont confrontés. Ils fonctionnent dans le clivage entre somatique et psychologique bien que ces deux aspects soient indissociables. Les adolescents sont souvent amenés en consultation par d’autres, dont les parents. Un travail d’identification de la demande réelle de l’adolescent est donc nécessaire pour que celui-ci puisse se mobiliser vers une prise en charge. La confidentialité est cruciale de même que le respect de l’adolescent, ainsi que la reconnaissance de ses craintes et des limites qu’il met à l’accès aux informations par l’anamnèse et l’examen clinique. Il appartient au médecin de lire la demande de l’adolescent dans un double registre, à la fois somatique et psychique et de resituer cette demande dans le contexte de vie particulier à l’adolescent. Aussi, la lecture de la demande intégrera non seulement les problèmes invoqués par l’adolescent mais aussi ceux relevés par l’anamnèse et l’examen clinique. Une telle lecture peut prendre du temps pour les intervenants de santé mais aussi pour l’adolescent, avant qu’il n’aboutisse à l’émergence de sa demande et, dès lors, à une demande de prise en charge. Celle-ci devra parfois faire appel à une équipe spécifique et pluridisciplinaire telle que celle où collaborent les auteurs du présent article, au Centre de Santé de l’Adolescent à Liège. [less ▲]

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See detailInternal and International migration. Chinese Perspectives.
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (2000), Vol. XVII

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See detailThe occurrence of 2-hydroxy-6-methoxybenzoic acid methyl ester in Securidaca longepedunculata Fresen root bark.
Lognay, Georges ULg; Marlier, M.; Seck, D. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4(2),

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See detailChants populaires flamands (1879) als wetenschappelijke getuigenis van een vroeg individueel repertoire: een voorstudie
Peere, Isabelle ULg

in Volkskunde (2000), (4),

This article is the summary of a lecture given on the 29th conference of the Kommission für Volksdichtung in Aberdeen in August 1999. The author tests the existing context literature on the well-known ... [more ▼]

This article is the summary of a lecture given on the 29th conference of the Kommission für Volksdichtung in Aberdeen in August 1999. The author tests the existing context literature on the well-known folk song collection 'Chants Populaires Flamands avec les airs notés et poésies populaires diverses recueillis à Bruges' by Ad.-R. Lootens and J.M.E. Feys with novel data and on the basis of these, she sets up some new hypotheses. The writer proves that Lootens and Feys might have been relatives and that Catherine Beyaert, Lootens 's mother was, most likely, the most important source of Lootens's fielswork. Moreover, she casts a new light on the collaboration between Lootens and Feys during the realization of the manuscript. [less ▲]

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See detailIpsilateral motor responses to focal transcranial magnetic stimulation in normal and stroke patients.
ALAGONA G.; DELVAUX, Valérie ULg; GERARD, Pascale ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2000), Neurosurgery and Psychiatry

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See detailcompte rendu de : B. Liou-Gille, Une lecture "religieuse" de Tite-Live I. Cultes, rites, croyances de la Rome archaïque
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (2000), 78(1), 241-244

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See detailLes relations ethniques aux USA au début du XXIème siècle
Martiniello, Marco ULg

in Actualité du Droit (2000), 3

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See detailA further locality with foliicolous lichens in Italy, with taxonomical and ecological data on foliicolous lichens in Western Europe
Puntillo, Domenico; Bricaud, Olivier; Sérusiaux, Emmanuël ULg

in Cryptogamie. Mycologie (2000), 21

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See detailHistologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Qu, Jianping et al

in Fertility and Sterility (2000), 74(1), 122-129

Objective: To compare histologic and ultrastructural characteristics of fresh and frozen-thawed human ovarian cortical tissue grafted into nude mice. Design: Experimental prospective study. Setting: An ... [more ▼]

Objective: To compare histologic and ultrastructural characteristics of fresh and frozen-thawed human ovarian cortical tissue grafted into nude mice. Design: Experimental prospective study. Setting: An academic research environment. Patient(s): Ovarian biopsy specimens were obtained from 13 women undergoing laparoscopy for tubal ligation or infertility. Animal(s): Forty nude mice. Intervention(s): A minilaparotomy was performed to place fresh and frozen-thawed ovarian grafts subcutaneously (sc) or intraperitoneally (ip). Removal of the ovarian grafts was performed at 24 days. Main Outcome Measure(s): [1] the follicular population, [2] fibrosis, [3] vascularization of the grafted tissue, and [4] ultrastructural evaluation. Result(s): A greater fibrosis relative surface area was noted in frozen-thawed transplanted tissue than in fresh transplants. Regardless of this fibrosis, a similar follicular density was observed in fresh and frozen-thawed ovarian tissue 24 days after transplantation. Active angiogenesis was proved by both immunohistochemical study of the vascular endothelial growth factor and morphometric study of the vascular network. Normal ultrastructural characteristics were noted in frozen-thawed ovarian biopsies. Conclusion(s): Angiogenesis allows implantation of the graft even if it has been cryopreserved and thawed similarly to implantation of fresh tissue. The greater fibrosis observed in grafts after cryopreservation and implantation does not seem to affect the primordial and primary ovocyte population and their ultrastructural characteristics, but further studies must be conducted to prove that after cryopreservation and transplantation, ovocytes may achieve full maturation and fertilization. [less ▲]

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See detailJudiciarisation et politique
Fournier, Bernard ULg; Woehrling, José

in Politique et sociétés (2000), 19(2-3), 320

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See detailConvergentie en divergentie in de Nederlandse standaardtaal. Het stripverhaal Suske en Wiske als casus.
Meesters, Gert ULg

in Nederlandse Taalkunde (2000), 5(2), 164-176

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See detailLes spatiocartes d'occupation du sol
Binard, Marc ULg; Donnay, Jean-Paul ULg

in Bulletin de la Société Géographique de Liège (2000), 38(2000/1), 63-78

Les spatiocartes d'occupation du sol sont dérivées de la classification d'une ou plusieurs images satellite selon une nomenclature conventionnelle des affectations du sol. En importance, elles constituent ... [more ▼]

Les spatiocartes d'occupation du sol sont dérivées de la classification d'une ou plusieurs images satellite selon une nomenclature conventionnelle des affectations du sol. En importance, elles constituent sans doute le second type de spatiocartes le plus couramment produit, après les spatiocartes en composition colorée. Vis-à-vis de ces dernières, les spatiocartes d'occupation du sol relèvent cependant d'une toute autre logique et procèdent d'une méthodologie très différente. La composition colorée est conçue pour laisser au lecteur le soin d'interpréter l'image en fonction de ses propres centres d'intérêt, et les techniques sélectionnées pour son élaboration doivent précisément favoriser la reconnaissance et l'identification visuelle d'un maximum de détails. La spatiocarte d'occupation du sol, par contre, répond à un objectif précis et déterminé a priori. Tout, depuis la sélection des images sources jusqu'à la sélection des couleurs, en passant par le choix de l'échelle et la fixation de la nomenclature, est dicté par une thématique unique. Les méthodes de classification, elles-mêmes, ne sont pas indépendantes de l'objectif poursuivi. Le but de ce chapitre n'est pourtant pas de discourir sur les multiples algorithmes de classification des images. Une très volumineuse littérature, en constante évolution, y est consacrée (Atkinson & Lewis, 2000, Chin-Teng et al., 2000, Simpson et al., 2000). Les méthodes les plus traditionnelles, relevant de l'interprétation d'images assistée par ordinateur, co-existent avec les méthodes les plus récentes, telles les classifications par réseaux de neurones ou les classifications bayesiennes. L'utilisation de l'une ou l'autre méthode, voire de plusieurs en chaîne, se justifie à l'occasion de tel ou tel cas de figure mais elles n'interfèrent guère sur la préoccupation présente qui consiste à transformer une image classée en une carte. On conçoit dès lors que les traitements dont il sera question se situent en aval du processus de classification proprement dit. Quelques considérations seront pourtant émises sur les préalables de la classification et sur la nature et la qualité de l'image classée, dans la mesure où elles peuvent orienter l'élaboration de la spatiocarte. Par contre, les divers traitements relevant de l'habillage ou de l'impression, communs à toute spatiocarte quelle qu'en soit la facture, sont réservés à des chapitres ultérieurs. De même, quelques opérations complexes, susceptibles d'intervenir dans la réalisation de certaines spatiocartes de l'occupation du sol, mais exigeant un bagage méthodologique important, sont développées dans des chapitres spécifiques auxquels nous renverrons le moment venu. [less ▲]

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See detailFirst insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz, Marianne ULg; Van de Ven, W. J.; Kas, K.

in Advances in Dental Research (2000), 14

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10 ... [more ▼]

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is various translocations involving 12q15. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8q12. The most frequently encountered aberration in this group is a t(3;8)(p21;q12). [less ▲]

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See detailDes astres à l'atome, de l'atome aux astres
Biémont, Emile ULg

in Lettre du FNRS (2000), 41

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See detailThe unseen face of humanitarian crisis in eastern Democratic Republic of Congo: was nutritional relief properly targeted?
Porignon, Denis ULg; Katulanya, I.; Elongo, L. et al

in Journal of epidemiology and community health (2000), 54(1), 6-9

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic ... [more ▼]

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic Republic of Congo. DESIGN: Cross sectional surveys. SETTING: Temporary and other settlements, in the town of Goma and surrounding rural areas. SUBJECTS: Anthropometric indicators of nutritional status and presence or absence of oedema were measured among 5121 children aged 6 to 59 months recruited by cluster sampling with probability proportional to size, between June and August 1995. RESULTS: Children in all locations demonstrated a typical pattern of growth deficit relative to international reference. Prevalence of acute malnutrition (wt/ht < -2 Z score) was higher among children in the rural non-refugee populations (3.8 and 5.8%) than among those in the urban non-refugee populations (1.4%) or in the refugee population living in temporary settlements (1.7%). Presence of oedema was scarcely noticed in camps (0.4%) while it was a common observation at least in the most remote rural areas (10.1%). As compared with baseline data collected in 1989, there is evidence that nutritional status was worsening in rural non-refugee populations. CONCLUSIONS: Children living in the main town or in the refugee camps benefited the most from nutritional relief while those in the rural non-refugee areas were ignored. This is a worrying case of inequity in nutritional relief. [less ▲]

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See detailCalendes et calendriers: du temps cyclique au temps historique
Biémont, Emile ULg

in Ciel (Le) (2000), 62

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See detailcompte rendu de : La 'parola' delle immagini e delle forme di scrittura. Modi e tecniche della comunicazione nel mondo antico
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (2000), 78(1), 200-203

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See detailNew f values in neutral lead obtained by time-resolved laser spectroscopy, and astrophysical applications
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Palmeri, P. et al

in Monthly Notices of the Royal Astronomical Society (2000), 312

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See detailFate of the nucleolar vacuole during resumption of cell cycle in pea cotyledonary buds
Jennane, A.; Thiry, Marc ULg; Diouri, M. et al

in Protoplasma (2000), 210(3-4), 172-178

Meristematic cells of pea cotyledonary buds blocked in G(0-1) state contain a small nucleolus with a large central clear area surrounded by a fibrillar rim. The nucleolar structure varies according to the ... [more ▼]

Meristematic cells of pea cotyledonary buds blocked in G(0-1) state contain a small nucleolus with a large central clear area surrounded by a fibrillar rim. The nucleolar structure varies according to the cell cycle from the G(0-1)-blocked state until the first mitoses occurring between 24 and 27 h after removal of the main stem. In order to better identify and understand the role of the central area in the nucleolar function, its content was investigated by cytochemical and terminal deoxynucleotidyl transferase-immunogold methods. The central area showed the characteristics of a vacuole commonly constituted of the condensed chromatin, ribonucleoprotein granules, and lack of argyrophilic proteins. 3 h alter decapitation, a thickening of the fibrillar rim occurred, accompanied by an increase of granules in the vacuole. After 6 h, the unique vacuole broke up into two to four small vacuoles in which the granules are more abundant. After 12 h the nucleolus acquired compact structure with few minute vacuoles dispersed over the fibrillar component. During the whole cell cycle, the condensed chromatin is always observed in the vacuole. Our findings suggest that the appearance of the vacuoles is subsequent to the output of preribosomes from nucleolus. These vacuoles might play a role in condensation and decondensation of the chromatin. [less ▲]

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See detailLe capital osseux : une épargne qui débute au berceau
Halkin, V; Reginster, Jean-Yves ULg

in L'agenda Pédiatrie (2000), 22

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See detailLa progression au sein de la narration en égyptien: Éléments d’une grammaire du texte
Winand, Jean ULg

in Bulletin de l’Institut Français d’Archéologie Orientale (2000), (100), 403-435

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See detailExperimental and theoretical radiative lifetimes, branching fractions, and oscillator strengths for Lu I and experimental lifetimes for Lu II and Lu III
Fedchak, J. A.; Den Hartog, E. A.; Lawler, J. E. et al

in Astrophysical Journal (2000), 542

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See detailSegmentation of multispectral images in optical metallography
Pirard, Eric ULg; Bertholet, Vincent

in Revue de Métallurgie - Sciences et Génie des Matériaux (2000), Fév. 2000

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See detailLa querelle judiciaire au sujet de l'indemnité forfaitaire en faveur de l'ONSS
Kefer, Fabienne ULg

in Journal des Tribunaux du Travail (2000)

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See detailResults of the tracer tests during the El Tremedal underground coal gasification at great depth
Pirard, Jean-Paul ULg; Brasseur, Alain; Coeme, Antoinette et al

in Fuel (2000), 79(5), 471-478

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases ... [more ▼]

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases progressively with the cumulated quantity of oxygen injected. Models based on exchange of matter between the flowing fluid and a transverse dead zone were used. Results indicate that the gasifier behaves almost like a small number of stirred tanks in series with a high level of back mixing. (C) 2000 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailInfluence of colors on habituation of visual evoked potentials in patients with migraine with aura and in healthy volunteers.
Afra, J; Ambrosini, A; Génicot, Roger ULg et al

in Headache (2000), 40(1), 36-40

OBJECTIVE: To investigate whether colored glasses influence the habituation of visual evoked potentials. BACKGROUND: We have previously shown that during pattern-reversal stimulations lasting 2 minutes ... [more ▼]

OBJECTIVE: To investigate whether colored glasses influence the habituation of visual evoked potentials. BACKGROUND: We have previously shown that during pattern-reversal stimulations lasting 2 minutes the amplitude of the visual evoked potential increases in migraine with and without aura between attacks, whereas it decreases in healthy volunteers. Red light was found to increase visually evoked EEG fast activity only in children with migraine with aura. Wearing rose-tinted glasses for 4 months decreased attack frequency in parallel with a reduction of the visually evoked EEG fast activity. METHODS: We compared the change in amplitude of the visual evoked potential using five different tinted glasses in 12 patients with migraine with aura and in 10 healthy volunteers. During continuous stimulation at 3.1 Hz, five blocks of 50 responses were sequentially averaged using red, yellow, green, blue, and grey glasses and without glasses in a random order and analyzed in terms of latencies and N1-P1 amplitudes. Amplitude changes were calculated for each block by comparison with the first block in every condition and analyzed statistically using Zerbe's method. RESULTS: In healthy volunteers, the visual evoked potential amplitude increased with red glasses compared to without glasses (P = .05) or with green glasses (P = .03). In patients with migraine with aura, no significant difference was detected using colored glasses. Our findings in healthy volunteers are in line with earlier reports of increased excitability of the human visual cortex when exposed to red light. The lack of such a pattern in patients with migraine with aura suggests that the visual cortex is interictally hypoexcitable rather than hyperexcitable, which is consistent with studies of transcranial magnetic stimulation. [less ▲]

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See detailMujinga ou la soumission inconsciente à l’idéologie régnante
Vanhaegendoren, Koen ULg

in Congo-Meuse. Revue des lettres belges et congolaises de langue française (2000), 4-5

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See detailLe Peuplier
Jourez, Benoît ULg; Quin, Jean-Philippe; Mertens, Patrick

in Courrier du Bois (2000), 40(131), 11-16

Essence de production par excellence, le peuplier revêt une importance économique non négligeable. L'extension de sa culture basée sur les nouveaux cultivars, la qualité de son bois et son aptitude à la ... [more ▼]

Essence de production par excellence, le peuplier revêt une importance économique non négligeable. L'extension de sa culture basée sur les nouveaux cultivars, la qualité de son bois et son aptitude à la transformation, en ont fait une essence qui a pris de l'importance dans certaines branches de l'industrie du bois. [less ▲]

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See detailVibrational Structure and Organization of Various Self-Assembled Alkanethiol Monolayers: a HREELS Study
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Langmuir (2000), 16

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R ... [more ▼]

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R-cycloalkyl-ö-alkanethiols on different gold substrates. The HREELS data are reported as a contribution to a general effort to assess the potential of electron spectroscopies in the elucidation of structural characteristics of organic surfaces. Typical fingerprints of the thiol molecules, characteristic of their primary and secondary structure (connectivity, conformation, and order), have been found in their HREELS vibrational spectra. We have shown that when the layers are disordered, the spectra are dominated by impact-excited modes, hampering the identification of the compounds. These data have evidenced many defects in the organization of the monolayers on evaporated gold substrates. The coherent domains sizes formed by the molecules in the films have been estimated from the angular distribution of the elastic peak as a function of the nature of the alkanethiol chain and of the immersion time in thiol solutions [less ▲]

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See detailWanze/Huccorgne : la grotte du Docteur
Miller, Rebecca ULg; Otte, Marcel ULg

in Chronique de l'Archéologie Wallonne (2000), 8

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See detailLa langue des testaments dans l'Egypte du IIIe siècle apr. J.-C.
Rochette, Bruno ULg

in Revue Internationale des Droits de l'Antiquité [= RIDA] (2000), 47

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See detailLa probatio internetica
Vanbrabant, Bernard ULg

in Actualités du Droit (2000)

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See detailFormes et formalités. Remarques sur la poétique du nom chez Mallarmé
Durand, Pascal ULg

in Formules (2000), 4

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See detailLe financement public des cultes, de la laïcité et des cours philosophiques
Husson, Jean-François ULg

in Courrier Hebdomadaire du CRISP (2000), (1703-1704), 3-90

This publication details all channels through which religious and philosophical communities in Belgium are financed by local, regional or federal governments. Institutional environment is described ... [more ▼]

This publication details all channels through which religious and philosophical communities in Belgium are financed by local, regional or federal governments. Institutional environment is described. Detailed budgetary data are provided and are set in perspective with sociological data on religious practices or belonging. [less ▲]

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See detailCorrelation of the proposed Conodont based Upper Devonian substages boundary levels into the neritic and terrestrial Miospore zonation
Streel, Maurice ULg; Loboziak

in Newsletter. Subcommission on Devonian Stratigraphy (2000), 17

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See detail1re campagne de fouille à Chagar Bazar (Syrie)
Tunca, Önhan ULg; McMahon, A.; Baghdo, Abd el-Massih

in Orient-Express 2000/1 (2000)

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See detailLe courant excito-moteur: aspects scientifiques et rééducatifs
Vanderthommen, Marc ULg

in Kine Acta (2000), 356

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See detailEpidemiologie, physiopathologie et traitement d'une affection frequente: tinea pedis.
Lambert, Jean-Luc ULg; Richert, Bertrand ULg; Dezfoulian, Bita ULg et al

in Revue Médicale de Liège (2000), 55(3), 161-8

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly ... [more ▼]

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly responsible for the increase of cases of tinea pedis as dermatophytes grow preferentially in warm and humid environments. The clinical aspect is affected by several factors such as the host reaction to the infection, the virulence of the infective strain, species, and some local and environmental factors. If a dermatophytosis is suspected, it is mandatory to validate the provisional diagnosis by demonstration of the fungus (by culture or/and microscopic examination) to avoid useless and expensive treatments. The new antifungal molecules are very effective, well tolerated and allow short course of therapy improving the compliance of the patient in clinical practice. Relapse of tinea pedis is very common but could be avoided by several simple preventive measures of hygiene. [less ▲]

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See detailcompte rendu de : Jacqueline Fabre-Serris, Mythologie et littérature à Rome. La réécriture des mythes aux Iers siècles avant et après J.-C.
Rochette, Bruno ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2000), 13

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See detailSilencing subdomains of v-ErbA interact cooperatively with corepressors: involvement of helices 5/6
Busch, Kerstin; Martin, Bernd; Baniahmad, Aria et al

in Molecular Endocrinology (Baltimore, Md.) (2000), 14(2), 201-11

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression ... [more ▼]

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression by TR in the absence of ligand is mediated by an active silencing mechanism. The oncogene v-ErbA is a variant form of TR unable to bind hormone and thus acts as a constitutive repressor. Functional studies and mutation analysis revealed that the TR/v-ErbA silencing domain is composed of three silencing subdomains (SSD1-3) which, although nonfunctional individually, synergize such that silencing activity is restored when they are combined in a heteromeric complex. Here we demonstrate, using protein interaction assays in vitro and in vivo, that the inactive v-ErbA point mutant L489R within helix 5/6 in SSD2 fails to interact with the two corepressors N-CoR (nuclear receptor corepressor) or SMRT (silencing mediator of retinoic acid and thyroid hormone receptor). Furthermore, mutants in SSD1 and SSD3 exhibit a reduced corepressor recruitment corresponding to their weak residual silencing activity. In mammalian two-hybrid assays, only the combination of all three silencing subdomains, SSD1-3, leads to a cooperative binding to the corepressors N-CoR or SMRT comparable to that of the full-length v-ErbA repression domain. In conclusion, full silencing activity requires corepressor interaction with all three silencing subdomains, SSD1-3. Among these, SSD2 is a new target for N-CoR and SMRT and is essential for corepressor binding and function. [less ▲]

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See detailLes orfèvres mosans devant l'histoire (XIe-XIIIe siècle)
George, Philippe ULg; Stiennon, Jacques ULg; Kupper, Jean-Louis ULg

in Bulletin de la Société Royale Le Vieux-Liège (2000)

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See detailProtective Effects Of A Live Attenuated Bovine Leukaemia Virus Vaccine With Deletion In The R3 And G4 Genes
Reichert, M.; Cantor, Gh.; Willems, Luc ULg et al

in Journal of General Virology (2000), 81

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See detailPulmonary perfusion redistribution in exercises horses
Votion, Dominique ULg; Harmegnies, N. F.; Duvivier, D. H. et al

in European Journal of Nuclear Medicine (2000), 41

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See detailLiège et Voltaire
Droixhe, Daniel ULg

in Bulletin de l'Académie Royale de Langue et de Littérature Françaises (2000), LXXVIII(1-2-3-4), 39-48

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See detailFollicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells.
Tsunoda, R.; Heinen, Ernst ULg; Sugai, N.

in Cell & Tissue Research (2000), 299(3), 395-402

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular ... [more ▼]

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular dendritic cells (FDC) are capable of regulating the susceptibility to apoptosis of GC B cells, we constructed a GC model in vitro: emperipolesis of tonsillar B cells by FDC. We then analyzed the expressions of apoptosis-related proteins (Bcl-2 and Fas) on the cells by three-color flow cytometry. B cells nonentrapped by FDC decreased rapidly in number owing to early apoptosis in vitro, whereas entrapped B cells were rescued for at least 18 h and showed peculiar regulation of Fas and Bcl-2. GC founder cells (CD38+, IgD+; GCFC) and GC B cells (CD38+, IgD-) showed approximately a twofold increased expression of Fas; in contrast, mantle zone B cells (CD38-, IgD+) and memory B cells (CD38-, IgD-) showed no changes. Bcl-2 expression in mantle zone and memory B cells was reduced by approximately one-half; however, GCFC and GC B cells continued to express little Bcl-2 and this did not change. Our findings strongly suggest that FDC play a part in the modulation of the susceptibility to apoptosis on B cells within GC. [less ▲]

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See detailEducation pour le troisième millénaire : mes craintes, mes espoirs ... pour l’Université
Merenne-Schoumaker, Bernadette ULg

in Education-Formation (2000), (259), 18-19

Courte réflexion sur les défis de l'Université en termes de formation au début du XXIe siécle

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See detailTrophics relationships between planktonic micro-organisms in the river Meuse (Belgium): a carbon budget
Servais, Pierre; Gosselain, Véronique; Joaquim-Justo, Célia ULg et al

in Arch. Hydrobiol (2000)

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See detailHyperammonemia after high-dose chemotherapy and stem cell transplantation.
Frere, Pascale ULg; Canivet, Jean-Luc ULg; Gennigens, Christine ULg et al

in Bone Marrow Transplantation (2000), 26(3), 343-5

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the ... [more ▼]

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the possibility of this diagnosis in patients developing confusion and neurological degradation with respiratory alkalosis after intensive chemotherapy, could allow earlier treatment and perhaps improved survival. Possible mechanisms and potential therapies are discussed. With rapid recognition and treatment of the syndrome, the patient fully recovered. One and a half years later, she is still alive and well, on interferon for persisting myeloma. [less ▲]

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See detailPatologia hipofisaria y NEM-1
Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg; Beckers, Albert ULg

in Revista Argentina de Endocrinologia y Metabolismo (2000), 37(3), 181-193

Multiple Endocrine Neoplasia type 1 (MEN 1) is an autosomal dominant syndrome characterized by neoplasia of the parathyroid glands, the endocrine pancreas and the anterior pituitary gland. Recently the ... [more ▼]

Multiple Endocrine Neoplasia type 1 (MEN 1) is an autosomal dominant syndrome characterized by neoplasia of the parathyroid glands, the endocrine pancreas and the anterior pituitary gland. Recently the identification on chromosome 11 (locus q13) of the gene responsible for MEN 1 has allowed direct genetic diagnosis of MEN 1-affected family members. To date almost 300 families have been described and genetically characterized. The genetic etiology of most pituitary tumours remains unknown. Pituitary adenomas can develop sporadically or as a part of multiple endocrine neoplasia type 1. In this review, the recently published data on the pathology of the MEN 1 syndrome will be summarized. The clinical, morphological and genetic aspects of sporadic and MEN 1-associated pituitary adenomas will be outlined. [less ▲]

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See detailPotato tubers exhibit both homolytic and heterolytic hydroperoxide fatty acid-cleaving activities
Fauconnier, Marie-Laure ULg; Delcarte, J.; Hoyaux, P. et al

in Biochemical Society Transactions (2000), 28(6), 853-855

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See detailClinical and neuropathological parameters affecting the diagnostic yield of nerve biopsy.
Deprez, Manuel ULg; de Groote, C. C.; Gollogly, L. et al

in Neuromuscular Disorders (2000), 10(2), 92-8

The value of nerve biopsy in the investigation of peripheral neuropathies is an important and controversial issue, partially obscured by the large variations in the diagnostic yield routinely reported for ... [more ▼]

The value of nerve biopsy in the investigation of peripheral neuropathies is an important and controversial issue, partially obscured by the large variations in the diagnostic yield routinely reported for this procedure. The aim of this study was to evaluate the clinical and neuropathological parameters affecting the yield of nerve biopsy. We compared the experience of two independent neuropathology laboratories with different patient recruitment and neuropathological methods over 11 years (01/1987-12/1997). Clinicopathological correlations were studied retrospectively in 355 patients. Using the same criteria of evaluation, contributive biopsies accounted for 35.5% in one laboratory, and 47.3% in the other. Clinical parameters affecting the yield of nerve biopsy were: (a) the presumptive diagnosis at time of referral for biopsy; (b) the distribution of symptoms; and (c) the interval between disease onset and biopsy. Greater yield was associated with clinically suspected vasculitis, inflammatory demyelinating neuropathy or hereditary sensorimotor neuropathies. Contributive findings were more often reported with multifocal or asymmetrical presentations, and onset-to-biopsy interval of less than 6 months. The contribution of nerve biopsy varied according to neuropathological techniques: (a) serial sections on frozen. paraffin-embedded and resin-embedded material improved sensitivity for interstitial pathology: (b) combined muscle biopsy increased sensitivity in the detection of vasculitis; and (c) teasing of nerve fibers added critical information to other classical techniques in only 4/102 cases. [less ▲]

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See detailInitial Medical Management of Severe Acute Ulcerative Colitis
Belaiche, Jacques ULg; Louis, Edouard ULg

in Acta Gastro-Enterologica Belgica (2000), 63(3, Jul-Sep), 275-8

Severe colitis is life-threatening complication of ulcerative colitis. Early recognition of the severity of the colitis, intensive medical therapy and prompt surgery when necessary have all contributed to ... [more ▼]

Severe colitis is life-threatening complication of ulcerative colitis. Early recognition of the severity of the colitis, intensive medical therapy and prompt surgery when necessary have all contributed to improved outcome. Initial medical treatment should be instituted as soon as the diagnosis is made with an intravenous corticosteroid associated with supportive treatment. If the patient fails to response to this intensive treatment after 5-7 days, cyclosporin should be initiated. If cyclosporin is not used then colectomy should be performed immediately. Moreover, significant deterioration at any point during medical therapy is an indication for colectomy. The gravity of the patient's condition require close interaction between physician an surgeon. [less ▲]

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See detailLa variation de l’équilibre glycémique (mais pas du poids) est corrélée positivement à la modification du risque cardiovasculaire absolu chez le patient diabétique
Hadjadj, Samy; Guilloteau, Gérard; Weekers, Laurent ULg et al

in Archives des Maladies du Coeur et des Vaisseaux (2000), 93(8), 1033-1036

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See detailManfred Matheis: Signaturen des Verschwindens : Das Bild des Philosophen in der Literatur und Philosophie um 1800
Viehöver, Vera ULg

in Philosophischer Literaturanzeiger (2000), 53(1), 12-14

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See detailLe développement folliculaire chez la vache. 2. Mécanismes hormonaux au cours du cycle et du postpartum.
Drion, Pierre ULg; Beckers, Jean-François ULg; Derkenne, F. et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailBauhinia L. in the Philippine Islands: aspects of diversity and vegetation units
Ruelle, S.; Malaisse, François ULg

in Geo-Eco-Trop (2000), 23(1-4), 49-62

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See detailThe cognitive management of daily life activities in patients with mild to moderate Alzheimer's disease me in a day care centre : A case report
Adam, Stéphane ULg; Van der Linden, Martial ULg; Juillerat, Anne- Claude et al

in Neuropsychological Rehabilitation (2000), 10(5), 485-509

The day care centre appears to be a structure especially well suited for the management of mild to moderate Alzheimer patients. It constitutes a place in which performance in everyday life activities can ... [more ▼]

The day care centre appears to be a structure especially well suited for the management of mild to moderate Alzheimer patients. It constitutes a place in which performance in everyday life activities can be explored, and optimisation strategies can be installed before they are used at home. Another objective of the day care centre might also be to provide caregivers with support and ease the burden that the daily care of a demented patient represents. Finally, it may also help to alleviate the patient's loneliness. In this perspective, we describe the general organisation of the recently-created day care centre at the University Hospital of Liege. We also present the assessment and intervention programme which was conducted in this day care centre in order to reduce the generalised apathy and depressed mood observed in a 70-year-old Alzheimer patient (AM). This programme aimed at restoring a leisure activity (knitting) at home by proposing several adaptations designed to minimise the impact of AM's cognitive deficits on knitting activity. While an aggravation of her memory deficits was observed, the intervention significantly decreased AM's apathy and depressed mood as well as her husband's burden. [less ▲]

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See detailHeadache tutorial.
Russell, M. B.; Nielsen, K. D.; Rasmussen, C. et al

in Studies in Health Technology & Informatics (2000), 78

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and ... [more ▼]

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and nomenclature. It is possible to move between the modules both vertically and horizontally. This paper concerns the headache tutorial. It consist of case records that the user can test his diagnostic abilities on. Each case record is subdivided into an interview by the physician, physical and neurological examination, laboratory test, sum of positive diagnostic elements, suggestions of diagnoses and management. A total of 12 case records are provided. The system will be available on a CD-ROM. [less ▲]

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See detailTheoretical Lifetimes and Oscillator Strengths in Ce II. Application to the Chemical Composition of the Sun
Palmeri, P.; Quinet, Pascal ULg; Wyart, J. F. et al

in Physica Scripta (2000), 61

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See detailConsidérations sur l'action en opposabilité d'un jugement étranger
Boularbah, Hakim ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2000)

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See detailPolitique et usage des manuels scolaires en mathématiques et en sciences
Monseur, Christian ULg; Demeuse, Marc ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 177-183

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See detailAb initio study of organic mixed valency
Dehareng, Dominique ULg; Dive, Georges ULg; Moradpour, Alec

in International Journal of Quantum Chemistry (2000), 76(4), 552-573

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by ... [more ▼]

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by full geometry optimization At both nuclear arrangements, mostly found as being minima in the symmetry-restrained Hartree-Fock framework, excitation energies were calculated through the expansion of the wave function on single electronic excitations of the Hart ee-Fock fundamental determinant and at the unrestricted Hartree-Fock or at the multiconfigurational self consistent field levels. Few calculations were also performed by taking into account some part of the electronic correlation. Except for N,N,N',N'-tetramethyl p-phenylenediamine, all the studied compounds are localized stable cations, at the symmetry-restrained Hartree-Fock level. However, the reoptimization of their wave function changes this observation since only three of them seem to conserve a localized stable conformation. Most of the studied systems are characterized by one or two excited electronic states very dose to the fundamental one and should thus present an unresolved broadened first absorption band in the near-infrared region These features are in agreement with the available experimental data. Strong Hartree-Fock instabilities are found for the delocalized structure and put in relation with the existence of the large nonadiabatic coupling in this conformational region. The solvent influence is discussed in the Onsager dipolar reaction field framework. (C) 2000 John Wiley & Sons, Inc. [less ▲]

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See detailEnantioseparation of aminoglutethimide with cyclodextrins in capillary electrophoresis and studies of selector-selectand interactions using NMR spectroscopy and electrospray ionization mass spectrometry.
Chankvetadze, Bezhan; Fillet, Marianne ULg; Burjanadze, N. et al

in Enantiomer (2000), 5(3-4), 313-22

The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs. The ... [more ▼]

The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs. The migration order of the enantiomers was opposite using beta-CD compared to alpha- and gamma-CDs as chiral selectors. In order to examine some underlying mechanisms of the chiral recognition the interaction of AGT with the chiral selectors was studied with one- and two-dimensional NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). The Job's and Scott's plots constructed based on the complexation-induced chemical shifts (CICS) observed in NMR spectra provided some preliminary information on the stoichiometry of the intermolecular complexes but did not seem to be absolutely reliable perhaps because the self-association of the analyte molecules and the formation of multiple type selectand-selector complexes. Therefore, an attempt was made to characterize the complexes using ESI-MS. This technique provided information on the stoichiometry and relative affinity constants of selector-selectand complexes. The information on the structure of complexes in the solution was obtained using one-dimensional rotating frame nuclear Overhauser enhancement (1D-ROESY) NMR spectroscopic studies. Significant differences were observed between the structures of the AGT complexes with beta- and gamma-CD. [less ▲]

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See detailIn vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR).
Mouithys-Mickalad, Ange ULg; Zheng, S. X.; Deby-Dupont, G. P. et al

in Free Radical Research (2000), 33(5), 607-21

OBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory drugs (NSAIDS), we examined by chemiluminescence (CL) and electron spin resonance (ESR) their scavenging properties ... [more ▼]

OBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory drugs (NSAIDS), we examined by chemiluminescence (CL) and electron spin resonance (ESR) their scavenging properties towards lipid peroxides, hypochlorous acid and peroxynitrite. METHODS: The antioxidant properties of nimesulide (NIM), 4-hydroxynimesulide (4-HONIM), aceclofenac (ACLO), 4-hydroxyaceclofenac (4-HOA-CLO), diclofenac (DICLO) and indomethacin (INDO) were tested on four different reactive oxygen species (ROS) generating systems: (I) phorbol-myristate acetate (PMA)-activated neutrophils, (II) Fe2+/ascorbate-induced lipid peroxidation, (III) HOCl-induced light emission, (IV) the kinetics of ONOO- decomposition followed by spectrophotometry. ROS production was monitored by luminol-enhanced CL or by ESR using two different spin traps. RESULTS: At 10 microM, ACLO, NIM, 4-HONIM, 4-HOA-CLO, and DICLO decreased luminol-enhanced CL generated by PMA-activated neutrophils. Inversely, INDO increased the luminol enhanced CL. Interestingly, hydroxylated metabolites were more potent antioxidants than the parent drugs. Furthermore, all drugs tested, excepted ACLO, lowered lipid peroxidation induced by Fe2+/ascorbate system. ACLO and DICLO, even at the highest concentration tested (100 microM), did not significantly lower HOCl induced CL, whereas the other drugs were potent scavengers. Finally, all the NSAIDS accelerated decomposition of ONOO-, suggesting a potential capacity of the molecules to scavenge peroxynitrite. CONCLUSION: The NSAIDs possess variable degrees of antioxidant activities, linked to their ability to react with HOCl, lipid peroxides or ONOO-. These antioxidant activities could offer interesting targeted side-effects in the treatment of joint inflammatory diseases. [less ▲]

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See detailEvidence for expression of some Microtubule-associated Protein 1B in neurons as a plasma membrane glycoprotein.
Franzen, Rachelle ULg; Tanner, Sandy; Jaffe, Howard et al

in Journal of Neurochemistry (2000), 75

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See detailSimilar Efficiency of DNA-Liposome Complexes and Retrovirus-Producing Cells for Hsv-Tk Suicide Gene Therapy of Peritoneal Carcinomatosis
Princen, Frederic; Lechanteur, Chantal ULg; Lopez, Marie-Josée ULg et al

in Journal of Drug Targeting (2000), 8(2), 79-89

Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 ... [more ▼]

Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment of peritoneal carcinomatosis induced in syngeneic rats by DHD/K12 colorectal adenocarcinoma cells. After in vitro determination of the best transduction conditions, rats were treated with multiple intraperitoneal injections of plasmid DNA containing one or two copies of CMV-driven HSV-tk gene (pCMV-TK and p(CMV-TK)2, respectively) associated with LipofectAMINE, each injection being followed by a Ganciclovir (GCV) course. Animals treated by DNA/liposome complexes and GCV or with retrovirus-producing cells and GCV showed a similar increase of survival as compared to the control group. After DNA/ liposome injections, expression of the tk transgene was detected in tumor nodes (epiploon) and also in liver, lung, spleen, bowels and brain. The expression was not homogeneous throughout the different organs and most likely reflected the transfection of only a limited number of cells. [less ▲]

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See detailHamstring muscle tear with recurrent complaints: An isokinetic profile
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Isokinetics & Exercise Science (2000), 8(3), 175-180

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See detailActivity and functional interaction of alternative oxidase and uncoupling protein in mitochondria from tomato fruit.
Sluse, Francis ULg; Jarmuszkiewicz, W.

in Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas (2000), 33

Cyanide-resistant alternative oxidase (AOX) is not limited to plant mitochondria and is widespread among several types of protists. The uncoupling protein (UCP) is much more widespread than previously ... [more ▼]

Cyanide-resistant alternative oxidase (AOX) is not limited to plant mitochondria and is widespread among several types of protists. The uncoupling protein (UCP) is much more widespread than previously believed, not only in tissues of higher animals but also in plants and in an amoeboid protozoan. The redox energy-dissipating pathway (AOX) and the proton electrochemical gradient energy-dissipating pathway (UCP) lead to the same final effect, i.e., a decrease in ATP synthesis and an increase in heat production. Studies with green tomato fruit mitochondria show that both proteins are present simultaneously in the membrane. This raises the question of a specific physiological role for each energy-dissipating system and of a possible functional connection between them (shared regulation). Linoleic acid, an abundant free fatty acid in plants which activates UCP, strongly inhibits cyanide-resistant respiration mediated by AOX. Moreover, studies of the evolution of AOX and UCP protein expression and of their activities during post-harvest ripening of tomato fruit show that AOX and plant UCP work sequentially: AOX activity decreases in early post-growing stages and UCP activity is decreased in late ripening stages. Electron partitioning between the alternative oxidase and the cytochrome pathway as well as H+ gradient partitioning between ATP synthase and UCP can be evaluated by the ADP/O method. This method facilitates description of the kinetics of energy-dissipating pathways and of ATP synthase when state 3 respiration is decreased by limitation of oxidizable substrate. [less ▲]

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See detailCharacterization of two Acacia gums and their fractions using a Langmuir film balance
Fauconnier, Marie-Laure ULg; Blecker, Christophe ULg; Groyne, J. et al

in Journal of Agricultural and Food Chemistry (2000), 48(7), 2709-2712

The mechanical properties of monolayers from two Acacia gums [Acacia senegal (L.) Willd. and Acacia seyal Del.] and their three fractions isolated by hydrophobic interaction chromatography were studied ... [more ▼]

The mechanical properties of monolayers from two Acacia gums [Acacia senegal (L.) Willd. and Acacia seyal Del.] and their three fractions isolated by hydrophobic interaction chromatography were studied with a Langmuir film balance to obtain a more complete understanding of their action mode. The analysis of compression isotherms revealed that A. senegal gums globally exhibit better interfacial properties than A. seyal ones. The behavior of the whole gums appeared to be strongly influenced by their arabinogalactan-protein complex. [less ▲]

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See detailMultivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis.
Fotsing, Lucas; Boulanger, Bruno ULg; Chiap, Patrice ULg et al

in Biomedical Chromatography : BMC (2000), 14(1), 10-1

Multivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis.

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See detailStructural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase.
Chantalat, L.; Duee, E.; Galleni, Moreno ULg et al

in Protein science : a publication of the Protein Society (2000), 9(7), 1402-6

Beta-lactamases are involved in bacterial resistance. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are becoming thus of major clinical importance. Despite the ... [more ▼]

Beta-lactamases are involved in bacterial resistance. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are becoming thus of major clinical importance. Despite the availability of Zn-beta-lactamase X-ray structures their mechanism of action is still unclear. One puzzling observation is the presence of one or two zincs in the active site. To aid in assessing the role of zinc content in beta-lactam hydrolysis, the replacement by Ser of the zinc-liganding residue Cys168 in the Zn-beta-lactamase from Bacillus cereus strain 569/H/9 was carried out: the mutant enzyme (C168S) is inactive in the mono-Zn form, but active in the di-Zn form. The structure of the mono-Zn form of the C168S mutant has been determined at 1.85 A resolution. Ser168 occupies the same position as Cys168 in the wild-type enzyme. The protein residues mostly affected by the mutation are Asp90-Arg91 and His210. A critical factor for the activity of the mono-Zn species is the distance between Asp90 and the Zn ion, which is controlled by Arg91: a slight movement of Asp90 impairs catalysis. The evolution of a large superfamily including Zn-beta-lactamases suggests that they may not all share the same mechanism. [less ▲]

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See detailStructure et fonctionnement de la mémoire : une approche neuropsychologique
Marczewski, Philippe; Van der Linden, Martial ULg; Collette, Fabienne ULg et al

in Confrontations Psychiatriques (2000), 41

Memory in not a unified system. It's composed of independant but interacting systems. Cognitive neuropsychology showed dissociations between these systems in patients with various brain lesions. The ... [more ▼]

Memory in not a unified system. It's composed of independant but interacting systems. Cognitive neuropsychology showed dissociations between these systems in patients with various brain lesions. The episodic memory system is devoted to the processing of personally lieved events. The predominant role played by frontal regions in underlying episodic memory has been fully documented. Moreover, the episodic memory disfunctions may lead to illusions of memory such as false memories, confabulations or hallucinations. [less ▲]

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See detail"note sous J.P. Jumet, 19 février 1998"
Moreau, Pierre ULg

in Actualités du Droit (2000)

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See detailHeparin-coated Wiktor stents in human coronary arteries (MENTOR trial). MENTOR Trial Investigators.
Vrolix, M. C.; Legrand, Victor ULg; Reiber, J. H. et al

in The American journal of cardiology (2000), 86(4), 385-9

The purpose of this study was to determine the feasibility, safety, and efficacy of elective stenting with heparin-coated Wiktor stents in patients with coronary artery disease. In experimental studies ... [more ▼]

The purpose of this study was to determine the feasibility, safety, and efficacy of elective stenting with heparin-coated Wiktor stents in patients with coronary artery disease. In experimental studies, heparin coating has been shown to prevent subacute thrombosis and restenosis. Recently, a new method of heparin coating was developed, resulting in a more stable and predictable heparin layer on stent devices. This trial constitutes the first in-human use of this coating procedure, applied on the well-known Wiktor stent device. Heparin-coated Wiktor stent implantation was performed in 132 consecutive patients (132 lesions) in a multicenter international trial from September 1996 to February 1997. Forty-three percent of patients had unstable angina, 33% had previous myocardial infarction, and 10% had diabetes mellitus. Patients were followed for 12 months for occurrence of major adverse cardiovascular events, and 96% of the eligible patients underwent quantitative angiographic control at 6 months. Stent deployment was successful in 95.5% of lesions. Minimal lumen diameter increased by 1.67 +/- 0.48 mm (from 1.02 +/- 0.38 mm before to 2.69 +/- 0.37 mm after the stent implantation). Mean percent diameter stenosis decreased from 67.4 +/- 11.3% before to 18.9 +/- 7.7% after the intervention. A successful intervention (<50% diameter stenosis and no major adverse cardiac events within 30 days) occurred in 97% of the patients. The subacute thrombosis rate was 0.8%, which compares favorably with historical controls of this stent, and a low incidence of postprocedural increase in creatine kinase-MB was noted. At 6 months, event-free survival was 85% and angiographic restenosis rate was 22% with late loss of 0.78 +/- 0.69 mm and a loss index of 0.48 +/- 0.44. Heparin-coated Wiktor stents appeared to be an efficacious device to treat Benestent-like lesions, yielding angiographic and clinical results comparable to a heparin-coated Palmaz-Schatz stent. Despite its use in more complex lesions, the incidence of subacute thrombosis appeared to be lower than historical controls with a similar noncoated stent. [less ▲]

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See detailQui gagnera la bataille des triptans ?
Schoenen, Jean ULg

in Médi Sphère (2000), (Fév/Mars), 17-18

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See detailRisedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group.
Fogelman, I; Ribot, C; Smith, R et al

in Journal of Clinical Endocrinology and Metabolism (2000), 85(5), 1895-900

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months ... [more ▼]

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months of placebo or risedronate (2.5 or 5 mg/day). All received calcium (1 g/day). The principal outcome measures were bone mineral density (BMD) at the lumbar spine, femoral neck, and femoral trochanter. At 24 months, lumbar spine BMD increased from baseline by 4% with 5 mg risedronate and 1.4% in the 2.5-mg group, compared with no change with placebo. Efficacy was similar in women who were less than 5 yr and more than 5 yr postmenopausal. At 24 months, risedronate (5 mg) had also increased BMD at the femoral neck and trochanter, whereas BMD decreased in the placebo group. BMD increases were seen at all three sites with risedronate (5 mg) after only 6 months of therapy. Risedronate was well tolerated; upper gastrointestinal adverse events were similar to placebo. We conclude that risedronate (5 mg) increases BMD rapidly and effectively and is well tolerated in postmenopausal women with low bone mass, regardless of time since menopause. [less ▲]

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See detailGenes upregulated during castration-induced rat prostatic apoptosis: cloning and characterization of new cDNAs.
Bruyninx, M.; Ammar, H.; Reiter, E. et al

in BJU International (2000), 85(9), 1134-42

OBJECTIVE: To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS: Differential display of mRNAs from 3-day ... [more ▼]

OBJECTIVE: To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS: Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybridized to confirm the positive regulation of the candidates and to follow the change in their expression in the involuting rat prostate, and in thymocytes of dexamethazone-treated rats. RESULTS: Five cDNAs were cloned: one encoding ribosomal protein L7, one coding for the insulin-like growth factor binding protein-3 (IGFBP-3), and three whose products are unknown. After castration, all five genes had expression kinetics that closely paralleled the proportion of prostatic epithelial cells undergoing apoptosis. The gene encoding L7 and two of the unknown genes were also upregulated in glucocorticoid-induced programmed death in thymocytes. In addition to the IGFBP-3 gene, those coding for proteins IGFBP-4, -5 and -6 were also overexpressed in the involuting prostate of androgen-deprived rats. CONCLUSION: Five new genes were identified that are up-regulated during castration-induced rat prostate apoptosis, three of which are potentially involved in the common intracellular pathway leading to programmed cell death. [less ▲]

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See detailNative gold, native silver, and secondary minerals in the quartz veins from Bastogne, Belgium
Hatert, Frédéric ULg; Deliens, Michel; Houssa, Michel et al

in Bulletin de l'Institut Royal des Sciences Naturelles de Belgique. Sciences de la Terre (2000), 70

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