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See detailIdentification of Brucella spp. genes involved in intracellular trafficking.
Delrue, R. M.; Martinez-Lorenzo, M.; Lestrate, P. et al

in Cellular Microbiology (2001), 3(7), 487-97

After uptake by host cells, the pathogen Brucella transits through early endosomes, evades phago-lysosome fusion and replicates in a compartment associated with the endoplasmic reticulum (ER). The ... [more ▼]

After uptake by host cells, the pathogen Brucella transits through early endosomes, evades phago-lysosome fusion and replicates in a compartment associated with the endoplasmic reticulum (ER). The molecular mechanisms underlying these processes are still poorly understood. To identify new bacterial factors involved in these processes, a library of 1800 Brucella melitensis 16M mini-Tn5catkm mutants was screened for intracellular survival and multiplication in HeLa cells and J774A.1 macrophages. Thirteen mutants were identified as defective for their intracellular survival in both cell types. In 12 of them, the transposon had inserted in the virB operon, which encodes a type IV-related secretion system. The preponderance of virB mutants demonstrates the importance of this secretion apparatus in the intracellular multiplication of B. melitensis. We also examined the intracellular fate of three virB mutants (virB2, virB4 and virB9) in HeLa cells by immunofluorescence. The three VirB proteins are not necessary for penetration and the inhibition of phago-lysosomal fusion within non-professional phagocytes. Rather, the virB mutants are unable to reach the replicative niche and reside in a membrane-bound vacuole expressing the late endosomal marker, LAMP1, and the sec61beta protein from the ER membrane, proteins that are present in autophagic vesicles originating from the ER. [less ▲]

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See detailLarge-Scale Phenotypic Analysis Reveals Identical Contributions To Cell Functions Of Known And Unknown Yeast Genes
Bianchi, Mm.; Ngo, S.; Vandenbol, Micheline ULg et al

in Yeast (2001), 18(15),

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See detailL'invention de la mélancolie. Note sur l'ancienneté de la photographie
Havelange, Carl ULg

in Journal Français de Psychiatrie. Clinique, Scientifique et Psychanalytique (2001), 16

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See detailA recombinant beta-O-glucosidase from Caldocellum saccharolyticum to hydrolyse desulfo-glucosinolates
Wathelet, Jean-Paul ULg; Iori, R.; Leoni, O. et al

in Biotechnology Letters (2001), 23(6), 443-446

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum ... [more ▼]

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum saccharolyticum does not catalyse glucosinolate degradation but can hydrolyse desulfo-glucosinolates (thio-D-glucosidic substrates) to produce the corresponding pure nitriles, including valuable homochiral representatives. [less ▲]

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See detailQuelques données sur les différentes prises en charge des délinquants sexuels dans les pays de l'Union européenne
Cornet, Jean-Philippe; Mormont, Christian ULg; Michel, Aude

in Annales Médico Psychologiques (2001), 159(9), 639-644

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See detailMechanisms of unconsciousness during general anaesthesia
BONHOMME, Vincent ULg; Hans, Pol

in Current Anaesthesia and Critical Care (2001), (12), 109-113

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See detailThe Vacuum UV Photoabsorption Spectrum of Methyl Chloride (CH3Cl) and its perdeuterated Isotopomer CD3Cl. I. A Rydberg Series Analysis.
Locht, Robert ULg; Leyh, Bernard ULg; Hoxha, A. et al

in Chemical Physics (2001), 272

The vacuum UV photoabsorption spectrum of CH3Cl has been recorded between 6 and 25 eV. A large number of vibronic bands are observed. These were partly ascribed to vibrationless Rydberg transitions. In ... [more ▼]

The vacuum UV photoabsorption spectrum of CH3Cl has been recorded between 6 and 25 eV. A large number of vibronic bands are observed. These were partly ascribed to vibrationless Rydberg transitions. In the higher energy range of 12-25 eV very weak diffuse bands are mostly assigned to transitions from the 3a1, 1e and 2a1 to 3s orbitals. In the 6-12 eV photon energy range, numerous weak to strong bands are observed. The sharpness of the features is very variable over the entire spectral region. In a first step, the interpretation of the spectrum and the assignment of the Rydberg transitions is based on the simple Rydberg formula. The observed features are classified in two groups of four series, each converging to one of the two spin-orbit components of the X2E state of CH3Cl+. Rydberg series of nsa1 (delta=1.069 and 1.064), npa1 (delta= 0.68 and 0.66), npe (delta= 0.438 and 0.427) and nd (delta= -0.040 and -0.092) characters are observed. The same measurements have been made for the first time on CD3Cl in the 6-12 eV photon energy range. The same Rydberg transitions are observed. Analogous series are characterized by about the same delta values: nsa1 (delta= 1.038 and 0.968), npa1 (delta= 0.65 and 0.61), npe (delta= 0.458 and 0.462) and nd (delta= -0.004 and -0.082). Ionization energies for CD3Cl X2E3/2 at 11.320 eV and X2E1/2 at 11.346 eV are deduced. In a second step, we fitted the experimental data for the nsa1 and npa1 states to an energy expression taking into account both the exchange interaction and the spin-orbit coupling. This accounts for the progressive switching from Hund's case (a) to Hund's case (c). [less ▲]

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See detailThe karyotype of the Formentera island garden dormouse, Eliomys quercinus ophiusae
Ramalhinho, Graça; Libois, Roland ULg

in Belgian Journal of Zoology (2001), 131(1), 83-85

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See detailHeterogeneity of (co)variance components for Jersey type traits
Gengler, Nicolas ULg; Dusseldorf, T.; Wiggans, G. R. et al

in Journal of Dairy Science (2001), 84

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See detailExperience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep
Laureys, Steven ULg; Peigneux, Philippe ULg; Phillips, Christophe ULg et al

in Neuroscience (2001), 105(3), 521-525

One function of sleep is hypothesized to be the reprocessing and consolidation of memory traces (Smith, 1995; Gais et al., 2000; McGaugh, 2000; Stickgold et al., 2000). At the cellular level, neuronal ... [more ▼]

One function of sleep is hypothesized to be the reprocessing and consolidation of memory traces (Smith, 1995; Gais et al., 2000; McGaugh, 2000; Stickgold et al., 2000). At the cellular level, neuronal reactivations during post-training sleep in animals have been observed in hippocampal (Wilson and McNaughton, 1994) and cortical (Amzica et al., 1997) neuronal populations. At the systems level, using positron emission tomography, we have recently shown that some brain areas reactivated during rapid-eye-movement sleep in human subjects previously trained on an implicit learning task (a serial reaction time task) (Maquet et al., 2000). These cortical reactivations, located in the left premotor area and bilateral cuneus, were thought to reflect the reprocessing - possibly the consolidation - of memory traces during post-training rapid-eye-movement sleep. Here, the experience-dependent functional connectivity of these brain regions is examined. It is shown that the left premotor cortex is functionally more correlated with the left posterior parietal cortex and bilateral pre-supplementary motor area during rapid-eye-movement sleep of subjects previously trained to the reaction time task compared to rapid-eye-movement sleep of untrained subjects. The increase in functional connectivity during post-training rapid-eye-movement sleep suggests that the brain areas reactivated during post-training rapid-eye-movement sleep participate in the optimization of the network that subtends subject's visuo-motor response. The optimization of this visuo-motor network during sleep could explain the gain in performance observed during the following day. [less ▲]

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See detailStratification of single-vessel coronary stenosis by ischemic threshold at the onset of wall motion abnormality during continuous monitoring of left ventricular function by semisupine exercise echocardiography.
Garot, J.; Hoffer, E. P.; Monin, J. L. et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2001), 14(8), 798-805

We studied the relation between the ischemic threshold at the onset of wall motion abnormality on exercise echocardiography (EE) and the severity of coronary stenosis in patients with 1-vessel coronary ... [more ▼]

We studied the relation between the ischemic threshold at the onset of wall motion abnormality on exercise echocardiography (EE) and the severity of coronary stenosis in patients with 1-vessel coronary artery disease (CAD). We screened 216 consecutive patients who underwent coronary angiography and EE for suspected CAD. Ninety-five (74 men; age, 56 +/- 12 years) satisfied the study criteria, that is, the presence of 1-vessel disease or no evidence of CAD on angiography and a normal baseline echocardiogram. Eighty-seven patients had 1-vessel CAD on angiography, and exercise-induced wall motion abnormality occurred in 73 (77%). Optimal cutoff values of percent diameter stenosis and minimal lumen diameter for predicting a positive EE were 61% (sensitivity and specificity of 76%) and 1.12 mm (sensitivity and specificity of 74%). Among patients with positive EE, heart rate-blood pressure product at ischemic threshold was correlated with quantitative coronary stenosis (r = -0.72, P <.001). The ischemic threshold from continuous monitoring of left ventricular function during semisupine EE is correlated with the severity of coronary stenosis among patients with 1-vessel disease and a normal resting echocardiogram. [less ▲]

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See detailWILSON "BOOZOO" CHAVIS - nécrologie
Sacré, Robert ULg

in Soul Bag (2001), (163), 42-43

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See detailNatural radiative lifetimes in Ce II
Zhang, Z. G.; Svanberg, S.; Jiang, Z. et al

in Physica Scripta (2001), 63

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See detailThe 'Aesthetics of Personalism' in Caryl Phillips's Writing: Complexity as a New Brand of Humanism
Ledent, Bénédicte ULg

in World Literature Written in English (2001), 39(1), 75-85

This paper attempts to underline the epistemological implications of Phillips's handling of diasporic history through a focus on individual lives in Cambridge (1991) and The Nature of Blood (1997). His ... [more ▼]

This paper attempts to underline the epistemological implications of Phillips's handling of diasporic history through a focus on individual lives in Cambridge (1991) and The Nature of Blood (1997). His confessional first-person narratives highlight the intricacies inherent in human nature, thereby resisting the globalizing discourse of liberal humanism. Even more importantly, his fictions seem to illustrate a new, more understanding approach to this often hackneyed term, for they give voice to individuals whose multiple differences are, paradoxically, part proof of a common humanity, viewed here as an inclusive rather than exclusive concept. [less ▲]

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See detailUrethral sphincterotomy for delivery of a vesical calculus in the mare: a case report
Deleuze, Stefan ULg; Hanzen, Christian ULg

in Annales de Médecine Vétérinaire (2001), 145(6, Suppl. S), 373-376

A case of a cystic calculus in a mare and the pathophysiology of urolithiasis are described. In this case a 268 g calculus measuring 9 x 6 cm was removed after urethro-sphincterotomy was performed on the ... [more ▼]

A case of a cystic calculus in a mare and the pathophysiology of urolithiasis are described. In this case a 268 g calculus measuring 9 x 6 cm was removed after urethro-sphincterotomy was performed on the standing mare. [less ▲]

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See detailLe transsexualisme et l'anorexie mentale : emprise et tyrannie de la subjectivité : approches méthodologiques
Mormont, Christian ULg; Frankignoul, A.; Michel, Aude

in Pratiques psychologiques (2001), (3), 25-36

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See detailLes etats preleucemiques: d'un modele experimental murin aux syndromes myelodysplasiques humains
Defresne, Marie-Paule ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2001), 156(1-2), 99-104105-6

Using a model of experimental leukemia in mice, we have demonstrated that tumor development depends upon interactions between preleukemic cells and their microenvironment whose functions are altered ... [more ▼]

Using a model of experimental leukemia in mice, we have demonstrated that tumor development depends upon interactions between preleukemic cells and their microenvironment whose functions are altered. Cytokine injections inhibit tumor development by inducing a functional restoration of this environment. Human myelodysplastic syndromes (MDS) are marrow pathologies considered as preleukemic stages. As in murine leukemias, it is possible that marrow environment could play a key role in their evolution. We currently establish a model of human hematopoiesis in NOD/SCID mice grafted with human bone fragments. We hope that this model would allow to analyse the role of the marrow stromal cells in MDS and to establish treatments restoring their functions. [less ▲]

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See detailThe short-range baryon baryon interaction in a chiral constituent quark model
Stancu, Floarea ULg; Glozman, Ya. L.

in Nuclear Physics A (2001), A683

The previous analysis of the short-range $NN$ repulsion originating from the Goldstone boson exchange hyperfine interaction between constituent quarks is revisited. We study in which respects the ... [more ▼]

The previous analysis of the short-range $NN$ repulsion originating from the Goldstone boson exchange hyperfine interaction between constituent quarks is revisited. We study in which respects the repulsion depends on the radial form of the spin-spin quark-quark force. We show that while the radial form affects the structure of the 6Q wave function, the short-range repulsion in the $NN$ system persists in any case. We extend our analysis to other $YN$ and $YY$ (flavor octet-octet) systems and demonstrate that the flavor-spin hyperfine interaction implies a short-range repulsion in these B=2 systems as well. [less ▲]

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See detailVaricella-Zoster virus gene expression in latently infected rat dorsal root ganglia.
Kennedy, P. G.; Grinfeld, E.; Bontems, Sébastien ULg et al

in Virology (2001), 289(2), 218-23

Latent infection of human ganglia with Varicella-Zoster virus (VZV) is characterized by a highly restricted pattern of viral gene expression. To enhance understanding of this process we used in situ ... [more ▼]

Latent infection of human ganglia with Varicella-Zoster virus (VZV) is characterized by a highly restricted pattern of viral gene expression. To enhance understanding of this process we used in situ hybridization (ISH) in a rat model of VZV latency to examine expression of RNA corresponding to eight different VZV genes in rat dorsal root ganglia (DRG) at various times after footpad inoculation with wild-type VZV. PCR in situ amplification was also used to determine the cell specificity of latent VZV DNA. It was found that the pattern of viral gene expression at 1 week after infection was different from that observed at the later times of 1 and 18 months after infection. Whereas multiple genes were expressed at 1 week after infection, gene expression was restricted at the later time points when latency had been established. At the later time points after infection the RNA transcripts expressed most frequently were those for VZV genes 21, 62, and 63. Gene 63 was expressed more than any other gene studied. While VZV DNA was detected almost exclusively in 5-10% of neurons, VZV RNA was detected in both neurons and nonneuronal cells at an approximate ratio of 3:1. A newly described monoclonal antibody to VZV gene 63-encoded protein was used to detect this protein in neuronal nuclei and cytoplasm in almost half of the DRG studied. These results demonstrate that (1) this rat model of latency has close similarities in terms of viral gene expression to human VZV latency which makes it a useful tool for studying this process and its experimental modulation and (2) expression of VZV gene 63 appears to be the single most consistent feature of VZV latency. [less ▲]

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See detailMémoire à court terme et pathologies du langage
Poncelet, Martine ULg; Majerus, Steve ULg; Van der Linden, Martial ULg

in Rééducation Orthophonique (2001), 208

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See detailExperimental and theoretical investigations of the electrical properties of undoped and magnesium-doped GaN layers
Nguyen, Ngoc Duy ULg; Germain, Marianne; Schmeits, Marcel et al

in Journal of Crystal Growth (2001), 230

The ac characteristics of GaN : Mg and undoped GaN layers, grown by MOVPE on sapphire substrates, are measured for a wide range of temperature and bias conditions, in order to investigate the effect of ... [more ▼]

The ac characteristics of GaN : Mg and undoped GaN layers, grown by MOVPE on sapphire substrates, are measured for a wide range of temperature and bias conditions, in order to investigate the effect of the magnesium-related level on the transport properties. Two peaks, whose height and position depend on the measurement temperature, are observed in the admittance curves (G/ω versus frequency) of the Mg-doped samples, whereas only one peak appears in undoped samples. The study of the frequency dependence of the impedance, with a model including the two metallic Au/GaN junctions, the GaN layer itself, shows that, besides the effect of the differential resistance of the layer which plays a role in both sample types, the presence of a Mg-related deep level contributes to the observed variations of the peaks in the admittance curves of the p-doped samples. Results of a theoretical steady-state and small-signal analysis based on numerical modelling of the Au/GaN/Au heterostructure complete our analysis. [less ▲]

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See detailUltrasonography of the Podotrochlear Apparatus in the Horse Using a Transcuneal Approach: Technique and Reference Images
Busoni, Valeria ULg; Denoix, Jean-Marie

in Veterinary Radiology & Ultrasound (2001), 42(6), 534-40

The purpose of this paper is to describe the technique for ultrasonographic examination of the podotrochlear apparatus in the horse using a transcuneal approach. In this study, ultrasound scans were ... [more ▼]

The purpose of this paper is to describe the technique for ultrasonographic examination of the podotrochlear apparatus in the horse using a transcuneal approach. In this study, ultrasound scans were performed in 3 normal cadaver limbs and 5 sound horses and images were compared to anatomic sections to establish the normal ultrasonographic anatomy of the podotrochlear apparatus. Detailed description of transverse and sagittal reference ultrasonographic images of this region is provided. This new imaging technique allows the assessment of the distal sesamoid bone flexor surface, the distal portion of the deep digital flexor tendon, the impar distal sesamoidean ligament, and the entheses of the distal phalanx. [less ▲]

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See detailOpettajankoulutus Belgiassa
Renaville, François ULg

in Tempus (2001), (1), 18-19

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See detailTreatment of drug-induced toxic epidermal necrolysis (Lyell’s syndrome) with intravenous human immunoglobulins
Paquet, Philippe ULg; JACOB, Eric; Damas, Pierre ULg et al

in Burns : Journal of the International Society for Burn Injuries (2001), 27(6), 652-655

Toxic epidermal necrolysis (TEN) is a rare drug-induced life-threatening disease. Currently, the disease is only treated by supportive and antiseptic measures. Quite recently intravenous immunoglobulins ... [more ▼]

Toxic epidermal necrolysis (TEN) is a rare drug-induced life-threatening disease. Currently, the disease is only treated by supportive and antiseptic measures. Quite recently intravenous immunoglobulins (IG) were shown to be a promising TEN treatment. The rationale for their use is based on the fact that keratinocyte apoptosis in TEN involves the CD95 (APO-1/Fas) cell surface receptor–ligand system. We successfully treated a TEN patient with high dose of intravenous IG. The clinical recovery appeared exceptionally rapid. Immunohistochemistry showed that the IG action probably developed on the CD95 receptor–ligand system at the keratinocytes surface. [less ▲]

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See detailEstimation of genetic covariances with Method R
Druet, Tom ULg; Misztal, I.; Duangjinda, M. et al

in Journal of Animal Science (2001), 79(3), 605-615

Method R is a simple and computationally inexpensive method for estimating (co)variances. The objective of the study was to investigate properties of Method R for estimation of (co)variance components ... [more ▼]

Method R is a simple and computationally inexpensive method for estimating (co)variances. The objective of the study was to investigate properties of Method R for estimation of (co)variance components with emphasis on covariance estimation. Theoretical Method R formulas were developed for simplified single-variate and bivariate models. In single-trait models, the curve of the regression of Method R was continuous and monotonic and its slope depended on the amount of information on each animal and on the variance ratio. The curve became steeper as the number of records per animal decreased. For covariance, the curve of the regression was monotonic but not continuous. However, a regression coefficient of 1 still corresponded to the correct covariance. Similar curves were observed in analyses of simulated data sets. Because of the observed discontinuity, algorithms implementing Method R that require a continuous regression curve would not work in models with: covariances. An alternative algorithm was based on a transformation matrix obtained by multiplying a matrix of numerators with the inverse of a matrix of denominators of the regression factors. Such an algorithm converged reliably for all models tested. Method R can be modified to estimate covariances in models too large for other methods. [less ▲]

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See detailProfils de la progestérone des vaches zébu ‘Azawak’ et taurin ‘Gourunsi’ après induction de l’œstrus aux progestagènes combinés à la prostaglandine
Zongo, M.; Pitala, W.; Boly, H. et al

in Tropicultura (2001), 19(3), 131-134

Un dosage radioimmunologique a été utilisé pour mesurer les concentrations de progestérone chez les zébus “Azawak” (Bos indicus, n = 6) et taurins Gourunsi (Bos taurus, n = 5) après induction de l'œstrus ... [more ▼]

Un dosage radioimmunologique a été utilisé pour mesurer les concentrations de progestérone chez les zébus “Azawak” (Bos indicus, n = 6) et taurins Gourunsi (Bos taurus, n = 5) après induction de l'œstrus. Les observations ont été menées sur 11 vaches non gestantes (groupe I composé de 3 zébus Azawak et 3 taurins Gourunsi; groupe II composé de 3 zébus Azawak et 2 taurins Gourunsi), soumises à un traitement hormonal reposant sur l’administration d’un implant de progestagène, d’une injection de prostaglandine F2alpha et, pour une partie des femelles (groupe I), d’une injection de PMSG. Les implants ont été placés sous la peau de la face externe de l’oreille et maintenus pendant une période de 10 jours. Au 8e jour du traitement, les femelles ont reçu une injection intramusculaire de prostaglandine F2 (5 mg/100 kg) et au 10e jour, au moment du retrait, une injection de PMSG (400 UI/300 kg de poids vif) a été pratiquée sur les animaux du groupe I. Chez les taurins Gourunsi et chez les zébus Azawak ayant reçu l’injection de PMSG, le traitement a été suivi d’un œstrus dans 2 cas sur 3. Chez les animaux appartenant au groupe II, l’œstrus ne fut observé chez aucun taurin et seulement chez 1 des 3 zébus. Les concentrations de progestérone mesurées au cours des phases lutéales qui ont suivi sont restées faibles chez les taurins Gourunsi. Chez les zébus Azawak, les concentrations se sont révélées plus élévées chez les femelles ayant reçu l’injection de PMSG (6,0 +/- 1,2 ng/ml) que chez celles qui n’avaient pas reçu (3,2 +/- 0,8 ng/ml). [less ▲]

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See detailL'avenir de l'enseignement
de Landsheere, Gilbert ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (5-6), 59-78

La Wallonie est, de longue tradition, pays d'éducation. Cela lui a valu la place de choix qu'elle occupe tant dans le domaine de l'économie que dans celui de la culture. Nous traversons actuellement une ... [more ▼]

La Wallonie est, de longue tradition, pays d'éducation. Cela lui a valu la place de choix qu'elle occupe tant dans le domaine de l'économie que dans celui de la culture. Nous traversons actuellement une période difficile. La restructuration politique de notre pays a absorbé beaucoup d'énergie et le long processus qui y a conduit n'a pas permis de prendre à temps, en particulier pour l'éducation, des décisions scientifiques et administratives urgentes. Le retard pris ainsi est alarmant et, s'il s'accentuait encore, il pourrait entraîner des décrochages et des pertes d'une gravité extrême. La chance veut que les connaissances nécessaires à l'élévation généralisée de la qualité de l'éducation et de sa productivité arrivent à maturité. On dispose ainsi d'éléments solides pour fonder les décisions et mettre en oeuvre une politique éducative qui nous permette d'entrer avec assurance dans le XXI ème siècle. Toute décision en matière d'éducation est indissociable de jugements de valeur et des réalités économiques et sociales. Ne fût-ce que par réalisme, les options humanistes et démocratiques s'imposent, car seuls ces deux idéaux sont garants de progrès et donnent l'espoir d'éviter des mouvements sociaux qui pourraient se solder par un désastre. En revanche, si la raison et la justice triomphent, la civilisation nouvelle qui émerge pourrait dépasser en qualité et en noblesse tout ce que l'humanité a connu jusqu'à présent. [less ▲]

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See detailThe effect of risedronate on hip fracture risk in elderly women with osteoporosis
Bensen, W; Eastell, R; Reginster, Jean-Yves ULg et al

in Journal of Rheumatology (2001), 28(S63), 24

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See detailPrincipes et intérêts du simulateur en anesthésie-réanimation
Larbuisson, Robert ULg; Nyssen, Anne-Sophie ULg; Janssens, Marc ULg et al

in Praticien en Anesthésie Réanimation (Le) (2001), 5(4), 225

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See detailDie endoluminale, kardiovaskuläre Radiotherapie:ein neuer Standard
Coucke, Philippe ULg; Ciernik, I-F

in Praxis (2001), 90

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of ... [more ▼]

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of coronary stenting further reducing cardiac morbidity. However, the incidence of restenosis after cardiovascular angioplasty remains high. The restenosis process is mainly explained by neo-intimal proliferation. Therefore, the utility of ionizing radiation has been systematically investigated in order to reduce proliferation of the neointimal tissue. Radiation therapy turns out to be a very efficient approach in reducing the rate of both de novo lesions as well as of instant restenosis. Recent clinical data from randomized trials confirm the utility of intracoronary radiation therapy and change the treatment standards in interventional cardiology. [less ▲]

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See detailRandomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study
Reinhart, Konrad; Menges, Thilo; Gardlund, Bengt et al

in Critical Care Medicine (2001), 29(4), 765-769

Objective: This study investigated whether treatment with the anti-tumor necrosis factor-a monoclonal antibody afelimomab would improve survival in septic patients with serum interleukin (IL)-6 ... [more ▼]

Objective: This study investigated whether treatment with the anti-tumor necrosis factor-a monoclonal antibody afelimomab would improve survival in septic patients with serum interleukin (IL)-6 concentrations of >1000 pg/mL. Design: Multicenter, double-blind, randomized, placebo-controlled study. Setting: Eighty-four intensive care units in academic medical centers in Europe and Israel. Patients: A total of 944 septic patients were screened and stratified by the results of a rapid qualitative immunostrip test for serum IL-6 concentrations. Patients with a positive test kit result indicating IL-6 concentrations of >1000 pg/mL were randomized to receive either afelimomab (n 5 224) or placebo (n 5 222). Patients with a negative IL-6 test (n 5 498) were not randomized and were followed up for 28 days. Interventions: Treatment consisted of 15-min infusions of 1 mg/kg afelimomab or matching placebo every 8 hrs for 3 days. Standard surgical and intensive care therapy was otherwise delivered. Measurements and Main Results: The study was terminated prematurely after an interim analysis estimated that the primary efficacy end points would not be met. The 28-day mortality rate in the nonrandomized patients (39.6%, 197 of 498) was significantly lower (p < .001) than that found in the randomized patients (55.8%, 249 of 446). The mortality rates in the IL-6 test kit positive patients randomized to afelimomab and placebo were similar, 54.0% (121 of 224) vs. 57.7% (128 of 222), respectively. Treatment with afelimomab was not associated with any particular adverse events. Conclusions: The IL-6 immunostrip test identified two distinct sepsis populations with significantly different mortality rates. A small (3.7%) absolute reduction in mortality rate was found in the afelimomab-treated patients. The treatment difference did not reach statistical significance. [less ▲]

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See detailB2 agonists cross the bovine placenta
Boutet, Philippe ULg; Uysterpruyst, C. H.; Degand, Guy ULg et al

in Pflügers Archiv : European Journal of Physiology (2001), 442(R41),

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See detailLes médias belges et l'"Etat social actif" : genèse, reproduction et diffusion du nouveau sens commun socio-économique
Geuens, Geoffrey ULg

in Quaderni : la Revue de la Communication (2001), 45 ("Figures du journalisme")

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See detailA STUDY OF VACUUM FREEZE-DRYING OF FROZEN WET PAPERS
Carapelle, Alain ULg; Henrist, Marc; Rabecki, Frédéric ULg

in Drying Technology (2001), 19(6), 1113-1124

Vacuum freeze-drying of frozen wet papers was investigated experimentally. A freeze-drying facility was built to study the process by monitoring the various physical parameters (pressure, sample ... [more ▼]

Vacuum freeze-drying of frozen wet papers was investigated experimentally. A freeze-drying facility was built to study the process by monitoring the various physical parameters (pressure, sample temperature, heater temperature, water content of the sample and cold panel temperature). A simple phenomenological model was developed to explain experimental results. The values of the physical parameters were optimized to make the process cost effective. [less ▲]

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See detailAssociations between casein haplotypes and first lactation milk production traits in Finnish Ayrshire cows
Ikonen, T.; Bovenhuis, H.; Ojala, M. et al

in Journal of Dairy Science (2001), 84(2), 507-514

The objective of this study was to estimate the effects of ß--casein (CN) haplotypes on first-lactation milk production traits. The ß--CN haplotypes were deduced using information on ß- and -CN genotypes ... [more ▼]

The objective of this study was to estimate the effects of ß--casein (CN) haplotypes on first-lactation milk production traits. The ß--CN haplotypes were deduced using information on ß- and -CN genotypes of cows and their sires for 16,973 Finnish Ayrshire cows that had at least nine paternal half sibs. Effects of CN haplotypes on milk production traits were estimated for one haplotype at a time using an animal model, which included the fixed effects for calving year and month, age at calving, days open, ß-lactoglobulin, and a ß--CN haplotype. Differences in milk production traits were also estimated between haplotype combinations A1A+A2B and A1B+A2A within ß--CN genotype A1A2AB and between combinations A1E+A2A and A1A+A2E within genotype A1A2AE. The ß--CN haplotypes A2A and A2B were associated with high milk and protein yields and low fat content, and those that included the ß-CN A1 allele were associated with low yields and high fat content. Protein content was affected by the -CN locus; haplotype A1B was associated with high protein content and A1E was with low protein content. The haplotype combination A1A+A2B was associated with 140 kg more milk yield (P = 0.045) and 0.03 percentage units less protein content (P = 0.055) than combination A1B+A2A, and combination A1A+A2E showed 0.02 percentage units greater protein content (P = 0.098) than A1E+A2A. These results indicate that genes linked to the CN loci contribute to the variation in milk yield and protein content. [less ▲]

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See detailN content of phloem and xylem exudates during the transition to flowering in Sinapis alba and Arabidopsis thaliana
Corbesier, Laurent; Havelange, Andrée ULg; Lejeune, Pierre et al

in Plant, Cell & Environment (2001), 24

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower ... [more ▼]

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower by one long day (LD). In S. alba, the phloem sap (leaf and apical exudates) and the xylem sap (root exudate) were analysed in LD versus SD. In A. thaliana, only the leaf exudate could be analysed but an alternative system for inducing flowering without day-length extension was used: the displaced SD (DSD). Significant results are: (i) in both species, the leaf exudate was enriched in Gln during the inductive LD, at a time compatible with export of the floral stimulus; (ii) in S. alba, the root export of amino acids decreased in LD, whereas the nitrate remained unchanged - thus the extra-Gln found in the leaf exudate should originate from the leaves; (iii) extra-Gln was also found very early in the apical exudate of S. alba in LD, together with more Glu; (iv) in A. thaliana induced by one DSD, the leaf export of Asn increased sharply, instead of Gln in LD. This agrees with Asn prevalence in C-limited plants. The putative role of amino acids in the transition to flowering is discussed. [less ▲]

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See detailRole de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumorale
Bajou, Khalid ULg; Devy, L.; Masson, Véronique ULg et al

in Thérapie (2001), 56(5, Sep-Oct), 465-72

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen ... [more ▼]

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen activation system, and paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been correlated with a poor prognosis for patients with cancers of different types. Recent findings clearly suggest that PAI-1 is essential for capillary sprouting during tumour angiogenesis. Moreover, there is accumulating evidence that both the urokinase receptor and PAI-1 are multifunctional proteins involved not only in extracellular matrix proteolysis but also in cellular adhesion and migration through their binding site for vitronectin. The understanding of whether PAI-1 plays a regulatory role in angiogenesis by tightly controlling proteolytic activity or by influencing cell migration could allow a new anti-angiogenic approach for tumour therapy. [less ▲]

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See detailSpécificités de la fonction cardiorespiratoire de l'âne (Equus asinus)
Delvaux, Véronique ULg; Kirschvink, Nathalie; Amory, Hélène ULg et al

in Pratique Vétérinaire Equine (2001), 33(129), 21-28

A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For ... [more ▼]

A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For particular tests (haematology, measurement of arterial blond gases, electrocardiogram with phonocardiogram and thoracic radiographs, cardias echography), no major differences were found. However, the mechanical ventilation parameters differed from those for horses and moere similar to Chose for food-producing animais (carde): a higher resistance, a lower compliance and a higher maximum pleural pressure variation moere found. The "respiratory strategy" adopted by certain donkeys is different from that of horses: there are two to three phases of inspiration with a nil airflow between each phase. Expiration is the same as for horses. The conformation of the pharynx and larynx is slightly different to that of horses making it more difficult to pass an endoscope through this area. The lower respiratory tract is sensitive and it is necessary to apply a local anaesthetic (xylocaine) for this examination. The différential leukocyte count from tracheal lavage includes a number of epithelial cells, and a higher percentage of eosinophils and neutrophile for donkeys compared to horses. These similarities and différences between donkeys and horses should be taken into account when performing ancillary tests [less ▲]

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See detailCatalytic asymmetric dihydroxylation of C,C double bonds with osmium tetroxide using selenoxides as co-oxidants
Krief, A.; Colaux, Catherine ULg

in Synlett (2001), (4), 501-504

Asymmetric dihydroxylation of olefins has been achieved in good yields and ee's using potassium osmate dihydrate (K2OsO2(OH)(4), the pre-oxidant), (DHQD)(2)PHAL (the chiral ligand), potassium carbonate ... [more ▼]

Asymmetric dihydroxylation of olefins has been achieved in good yields and ee's using potassium osmate dihydrate (K2OsO2(OH)(4), the pre-oxidant), (DHQD)(2)PHAL (the chiral ligand), potassium carbonate (the base) and selenoxides (the co-oxidants). Bath the yield and the ee proved to be pH dependent, the highest yield and ee being found at almost the same pH values. The rate of the reaction was found to be highly dependent upon the structure of the selenoxide used. Some representative examples involving aminoxides are presented for comparison. [less ▲]

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See detailHeroic Fantasy et modernité: la problématique de la quête chez Michael Moorcock et Samuel R. Delany
Delville, Michel ULg

in Sources: Revue d'Etudes Anglophones (2001), 11

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See detailOn the influence of aluminium content on the stability of retained austenite in multiphase TRIP-assisted steels
Mertens, Anne ULg; Jacques, Pascal J.; Lazarova, Roumiana et al

in Journal de Physique IV (2001), 11

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See detailOn the origin and systematics of the northern African wood mouse (Apodemus sylvaticus) populations: a comparative study of mtDNA restriction patterns
Libois, Roland ULg; Michaux, Johan ULg; Ramalhinho, M. G. et al

in Canadian Journal of Zoology (2001), 79(8), 1503-1511

Conflicting hypotheses have been formulated regarding the origin of wood mouse (Apodemus sylvaticus) populations in northern Africa. In this study, the mtDNA restriction patterns of mice (n = 28 ... [more ▼]

Conflicting hypotheses have been formulated regarding the origin of wood mouse (Apodemus sylvaticus) populations in northern Africa. In this study, the mtDNA restriction patterns of mice (n = 28) collected in Tunisia and Morocco are compared with those of representatives from southern Europe (n = 102). The neighbour-joining tree confirms the existence of the three lineages previously found in the Mediterranean area: western, Tyrrhenian-Balkan, and Sicilian. The western group is isolated from the two others, with bootstrap values of 89 and 95%. Northern African patterns are included in the western group. Their variability is low, the same pattern being shared by five Tunisian and all Moroccan animals (n = 18), caught either in the north of the country (Cap Spartel) or in the south (Marrakech). This implies that northern African wood mouse populations have a southwestern European origin and that their presence in the region is probably recent, which corresponds to both paleontological data and the hypothesis of anthropogenic introduction. [less ▲]

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See detailTeloptosis, a Turning Point in Hair Shedding Biorhythms
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 203(2), 115-7

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from ... [more ▼]

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from teloptosis. Both events are triggered by distinct factors. Indeed, teloptosis is the result of the loss of adhesion between cells of the club hair and those of its epithelial envelope. Teloptosis synchronization is perceived as telogen effluvium, related or not to shortening of the anagen phase. Subtle changes leading to early or delayed teloptosis affect hair density. It is possible to distinguish two types of telogen hairs on a trichogram. Those with an epithelial sheath indicate strong binding, suggesting early telogen, whereas the absence of an epithelial sheath indicates loose binding, conveying teloptosis. [less ▲]

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See detailNeuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro
Calaora, Viviane; Rogister, Bernard ULg; Bismuth, Karen et al

in Journal of Neuroscience (2001), 21

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See detailIntégration régionale et démocratie. Quelques réflexions à partir de la pensée d'Alexis de Tocqueville
Carlier, Jean-Yves ULg

in Revue Burkinabè du droit (2001), (39-40), 9-20

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See detailOrientation And Effects Of Mastoparan X On Phospholipid Bicelles
Whiles, Ja.; Brasseur, Robert ULg; Glover, Kj. et al

in Biophysical Journal (2001), 80(1), 280-93

Mastoparan X (MPX: INWKGIAAMAKKLL-NH2) belongs to a family of ionophoric peptides found in wasp venom. Upon binding to the membrane, MPX increases the cell's permeability to cations leading to a ... [more ▼]

Mastoparan X (MPX: INWKGIAAMAKKLL-NH2) belongs to a family of ionophoric peptides found in wasp venom. Upon binding to the membrane, MPX increases the cell's permeability to cations leading to a disruption in the electrolyte balance and cell lysis. This process is thought to occur either through a membrane-thinning mechanism, where the peptide resides on the membrane surface thereby disrupting lipid packing, or through formation of an oligomeric pore. To address this issue, we have used both high-resolution and solid-state 2H NMR techniques to study the structure and orientation of MPX when associated with bicelles. NOESY and chemical shift analysis showed that in bicelles, MPX formed a well-structured amphipathic alpha-helix. In zwitterionic bicelles, the helical axis was found to rest generally perpendicular to the membrane normal, which could be consistent with the "carpet" mechanism for lytic activity. In anionic bicelles, on the other hand, the helical axis was generally parallel to the membrane normal, which is more consistent with the pore model for lytic activity. In addition, MPX caused significant disruption in lipid packing of the negatively charged phospholipids. Taken together, these results show that MPX associates differently with zwitterionic membranes, where it rests parallel to the surface, compared with negatively charged membranes, where it penetrates longitudinally. [less ▲]

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See detailMélanges Fritz Sturm, compte rendu d’ouvrage
Langenaken, Evelyne ULg

in Actualités du droit (2001)

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See detailCoordinated regulation of procollagens I and III and their post-translational enzymes by dissipation of mechanical tension in human dermal fibroblasts.
Lambert, Charles ULg; Colige, Alain ULg; Lapiere, C. M. et al

in European Journal of Cell Biology (2001), 80(7), 479-85

Mechanical tension governs fibroblast proliferation and survival and the homeostasis of the extracellular matrix to adapt its resistance to the mechanical requirements of the organs. To consolidate this ... [more ▼]

Mechanical tension governs fibroblast proliferation and survival and the homeostasis of the extracellular matrix to adapt its resistance to the mechanical requirements of the organs. To consolidate this view, we analysed the effect of tension release on the expression of molecules involved in the architecture and stabilisation of the collagen fibres, namely the procollagens type I and III, the amino- and carboxy-procollagen peptidases (N-pCP and C-pCP) and lysyl oxidase. Cells were cultured in conditions of high mechanical stress in monolayer on a collagen coat and under reduced tension by disruption of the cytoskeleton upon treatment with cytochalasin D in monolayer on a collagen coat or by integrin-mediated stress relaxation in a freely retracting collagen gel. The mRNAs were measured by quantitative RT-PCR monitored by simultaneous reverse-transcription and amplification of an original internal standard. Tension relaxation resulted in a decreased expression of the procollagens type I and III, of the two expressed forms of C-pCP, of the two forms of N-pCP and of lysyl oxidase. Type III collagen, known to control diameter of the fibres, was less down-regulated than type I collagen. Interestingly, the expression of the two alternatively spliced forms of the N-pCP was dissimilarly regulated. These data suggest that mechanical tension may modulate the stiffness of the extracellular matrix by controlling not only the level of expression of its fibrillar constituents but also that of the enzymes participating in their extracellular processing and mechanical stabilisation. [less ▲]

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See detailAlpha-2-adrenoreceptors in depressed suicide attempters : relationship with medical lethality of the attempt
Pitchot, William ULg; Hansenne, Michel ULg; Pinto, Emmanuel ULg et al

in Neuropsychobiology (2001), 44(2), 91-94

Several lines of evidence tend to suggest a role for noradrenaline, and more specifically alpha-2-adrenoreceptors, in the biology of suicidal behavior. The purpose of this study was to assess the growth ... [more ▼]

Several lines of evidence tend to suggest a role for noradrenaline, and more specifically alpha-2-adrenoreceptors, in the biology of suicidal behavior. The purpose of this study was to assess the growth hormone (GH) response to clonidine, an alpha-2-adrenergic agonist, in majorly depressed inpatients with a history of highly lethal suicide attempt compared to depressed patients with a history of low lethal suicide attempt and nonattempters. Our sample included 20 male depressed inpatients with a history of suicide attempt compared to 20 male depressed nonattempters. We did not observe any significant difference between suicide attempters and nonattempters for GH peak values (2.4 +/- 2.9 vs. 4.1 +/- 3.7 ng/ml; F = 2.52, d.f. = 1, 38, p = 0.12). Moreover, GH peak responses to clonidine were not related to the degree of lethality of the attempt. The results of the present study do not support a major role for noradrenaline in the biology of suicidal behavior. [less ▲]

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See detailInfections virales humaines d'origine alimentaire
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Point Vétérinaire (2001), 218

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See detailCysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.
Bounaga, S.; Galleni, Moreno ULg; Laws, A. P. et al

in Bioorganic & medicinal chemistry (2001), 9(2), 503-10

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion ... [more ▼]

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site. [less ▲]

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See detailLa réforme de la procédure fiscale : le point de vue de la Cour d’arbitrage
Orban, Lionel ULg

in Fiscalité 2001. Le point sur les réformes », Journée d’études du Mercredi 31 octobre 2001, organisée par le Service de droit fiscal de la Faculté de droit de l’Université de Liège (2001)

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See detailAntimicrobial susceptilities of Salmonella strains isolated from food animals.
Van Looveren, M.; Daube, Georges ULg; De Zutter, L. et al

in Antimicrobial Agents and Chemotherapy (2001), 48

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See detailCarbon balance gradient in European forests: should we doubt 'surprising' results? A reply to Piovesan & Adams
Jarvis, P. G.; Dolman, A. J.; Schulze, E. D. et al

in Journal of Vegetation Science (2001), 12(1), 145-150

This paper responds to the Forum contribution by Piovesan & Adams (2000) who criticized the results obtained by the EUROFLUX network on carbon fluxes of several European forests. The major point of ... [more ▼]

This paper responds to the Forum contribution by Piovesan & Adams (2000) who criticized the results obtained by the EUROFLUX network on carbon fluxes of several European forests. The major point of criticism was that the data provided by EUROFLUX are inconsistent with current scientific understanding. It is argued that understanding the terrestrial global carbon cycle requires more than simply restating what was known previously, and that Piovesan & Adams have not been able to show any major conflicts between our findings and ecosystem or atmospheric-transport theories. [less ▲]

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See detailStraylight tests for the Heliospheric imagers of STEREO
Defise, Jean-Marc ULg; Halain, Jean-Philippe ULg; Mazy, Emmanuel ULg et al

in ESA-SP (2001), 467

The design of the Heliospheric Imager (HI) of the NASA Solar TErrestrial Relations Observatory (STEREO) is based on an optical baffle system. It will reject the solar disk light with attenuation of the ... [more ▼]

The design of the Heliospheric Imager (HI) of the NASA Solar TErrestrial Relations Observatory (STEREO) is based on an optical baffle system. It will reject the solar disk light with attenuation of the order of 10-13 and 10-15, and let two separate camera systems (HI-1 and HI-2) measure the extremely faint solar coronal mass ejections. A multi-vane diffractive system has been optimized to achieve the lower requirement (10-13 for HI-1) and is combined with a secondary baffling system to reach the 10-15 rejection performance in the second camera system (HI-2). The theoretical performances of the baffling systems will be experimentally verified during the instrument development phase. A specific straylight test facility is being studied at CSL and preliminary tests have been conducted to prepare the HI instrument testing. The test set-up requirements and design considerations are discussed in this paper. The very high rejection performance requires to perform those tests under vacuum to avoid ambient air perturbations. Several light trapping systems have been developed for this application. A first breadboard has been built and is currently under testing. Preliminary results of those tests are presented. [less ▲]

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See detailMicro-analyse des mécanismes de la reprise démographique des villages de l'Ardenne du Nord-Est : le cas de Burtonville
Schmitz, Serge ULg

in Espace, Populations, Sociétés (2001)

If they are well selected, macro scale analyses permit to underline some mechanisms that remain hidden or are difficult to distinguish with micro scale analysis. The populations' stories an history of ... [more ▼]

If they are well selected, macro scale analyses permit to underline some mechanisms that remain hidden or are difficult to distinguish with micro scale analysis. The populations' stories an history of Burtonville in their regional context show : - lags of demographic revivals between villages and small towns - relevance of material constraints inherent in a small village for the demographic development - relevance of landed property and genealogy for the village evolution - links between demographic and economic evolutions - diversification of environmental aspirations and their results on migrations. [less ▲]

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See detailCharacterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties.
Franceschini, N.; Boschi, L.; Pollini, S. et al

in Antimicrobial agents and chemotherapy (2001), 45(12), 3509-16

A class D beta-lactamase determinant was isolated from the genome of Legionella (Fluoribacter) gormanii ATCC 33297(T). The enzyme, named OXA-29, is quite divergent from other class D beta-lactamases ... [more ▼]

A class D beta-lactamase determinant was isolated from the genome of Legionella (Fluoribacter) gormanii ATCC 33297(T). The enzyme, named OXA-29, is quite divergent from other class D beta-lactamases, being more similar (33 to 43% amino acid identity) to those of groups III (OXA-1) and IV (OXA-9, OXA-12, OXA-18, and OXA-22) than to other class D enzymes (21 to 24% sequence identity). Phylogenetic analysis confirmed the closer ancestry of OXA-29 with members of the former groups. The OXA-29 enzyme was purified from an Escherichia coli strain overexpressing the gene via a T7-based expression system by a single ion-exchange chromatography step on S-Sepharose. The mature enzyme consists of a 28.5-kDa polypeptide and exhibits an isoelectric pH of >9. Analysis of the kinetic parameters of OXA-29 revealed efficient activity (k(cat)/K(m) ratios of >10(5) M(-1) x s(-1)) for several penam compounds (oxacillin, methicillin, penicillin G, ampicillin, carbenicillin, and piperacillin) and also for cefazolin and nitrocefin. Oxyimino cephalosporins and aztreonam were also hydrolyzed, although less efficiently (k(cat)/K(m) ratios of around 10(3) M(-1) x s(-1)). Carbapenems were neither hydrolyzed nor inhibitory. OXA-29 was inhibited by BRL 42715 (50% inhibitory concentration [IC(50)], 0.44 microM) and by tazobactam (IC(50), 3.2 microM), but not by clavulanate. It was also unusually resistant to chloride ions (IC(50), >100 mM). Unlike OXA-10, OXA-29 was apparently found as a dimer both in diluted solutions and in the presence of EDTA. Its activity was either unaffected or inhibited by divalent cations. OXA-29 is a new class D beta-lactamase that exhibits some unusual properties likely reflecting original structural and mechanistic features. [less ▲]

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See detailKey criteria for the design of polymeric stabilizers for aqueous titanium dioxide dispersions of high solid content
Creutz, Serge; Jérôme, Robert ULg

in e-Polymers (2001), (14), 1-9

Amphiphilic copolymers consisting of an animated hydrophobic block and a hydrophilic poly(sodium methacrylate) one have been synthesized with different structures and tested as stabilizers for aqueous ... [more ▼]

Amphiphilic copolymers consisting of an animated hydrophobic block and a hydrophilic poly(sodium methacrylate) one have been synthesized with different structures and tested as stabilizers for aqueous dispersions of alumina coated titanium dioxide (80 wt.-% solid). The dispersion stability is ruled by the strength of the anchoring of the aminated block onto the pigment and by the dynamics of the micelles formed by the copolymer. Any decrease in the anchoring strength, for example as a result of higher steric hindrance for the adsorbing block or of random rather than blocky distribution of the aminated co-units, is detrimental to the dispersion stability and makes this stability more dependent on the copolymer composition. Indeed, the position and dynamics of the unimers micelles equilibrium then control the adsorption of the copolymer on the pigment during the grinding process. [less ▲]

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See detailModèle de productivité et tarif de cubage des peuplements de teck (tectona grandis L. F.) au Sud-Bénin
Fonton, N. H.; Palm, Rodolphe ULg; Akossou, A. Y. J. et al

in Annales des Sciences Agronomiques du Bénin (2001), 2(2), 209-224

This study aims to build site index model and stem volume function of pure, even aged and relatively homogeneous teak stands in south Benin. The characteristics of the stands were obtained from the ... [more ▼]

This study aims to build site index model and stem volume function of pure, even aged and relatively homogeneous teak stands in south Benin. The characteristics of the stands were obtained from the inventory of 104 temporary plots sampled from stands with different ages and fertility. The stem analysis of 19 dominant trees wer used to establish, by serial regression, a model giving the evolution of top height according to the age. The site index curves were built in order to determine site index of the stands. The estimated volume function obtained shows that age, site index and basal area are the main stand parameters of stem volume funtion. [less ▲]

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See detailBulletin bibliographique de la Société Rencesvals 2000-2001
Henrard, Nadine ULg

in Bulletin Bibliographique de la Société Rencesvals pour l'étude des épopées romanes (2001), (32), 1-237

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See detailAtomic transition probabilities in Bi II
Palmeri, P.; Quinet, Pascal ULg; Biémont, Emile ULg

in Physica Scripta (2001), 63

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See detailQuantitative cell dispersion analysis: new test to measure tumor cell aggressiveness
Nawrocki-Raby, Béatrice; Polette, Myriam; Gilles, Christine ULg et al

in International Journal of Cancer = Journal International du Cancer (2001), 93(5), 644-52

Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between ... [more ▼]

Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between cell dispersion and cell invasion, related respectively to expression of E-cadherin/catenin complex and matrix metalloproteinases (MMPs), we developed an original in vitro model of cell dispersion analysis. Our study reports the validation of this model that allowed us to analyze and quantify the cell cohesion level by means of time-lapse videomicroscopy and computer analysis based on the observation of spatial and temporal cell distribution. Our model was able to distinguish 2 groups among different human bronchial and mammary epithelial cells previously characterized for the expression of E-cadherin/catenin complex and MMPs and their invasive capacity in the Boyden chamber assay. The first group (16HBE14o-, MCF-7, T47D) that expressed membranous E-cadherin and -catenin, and was negative for MMP-2 expression and non-invasive, displayed a highly cohesive pattern corresponding to a cluster spatial distribution. The second group (Beas2B, BZR, BZR-T33, MDA-MB-231, MDA-MB-435, BT549 and HS578T) that was invasive and showed lack of expression of E-cadherin and a cytoplasmic redistribution of -catenin, displayed a dispersed pattern corresponding to a random spatial distribution. Downregulation of E-cadherin by a blocking antibody induced a more random distribution. Conversely, expression of E-cadherin by cDNA transfection induced a cluster distribution. Moreover, tumor cell lines that co-expressed MT1-MMP and MMP-2 (Beas2B, BZR, BZR-T33, MDA-MB-435, BT549 and HS578T) showed a more dispersed pattern than tumor cell lines that did not express MMP-2 (MDA-MB-231). In conclusion, we demonstrated that the spatial group behavior of cell lines, i.e., their cohesion/dispersion ability, reflects their invasive properties. Thus, this model of cell dispersion analysis may represent a new test to measure tumor cell aggressiveness. [less ▲]

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See detailComparative study of twenty nine non parametric interaction tests in two-way layouts
Van Belle, Laurent; Claustriaux, Jean-Jacques ULg

in Multiciência (2001), 4(2), 179-196

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See detail7-Chloro-2-methyl-3-methylamino-2H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Somers, F.; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detailCrystallization and preliminary X-ray analysis of a bacterial psychrophilic enzyme, phosphoglycerate kinase
Mandelman, D.; Bentahir, M.; Feller, Georges ULg et al

in Acta Crystallographica Section D-Biological Crystallography (2001), 57(Pt 11), 1666-8

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and ... [more ▼]

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and decreased thermostability relative to its mesophilic counterpart. Herein, the preliminary crystallization and structure solution of psychrophilic PGK in its native form and cocrystallized with 3-phosphoglyceric acid (3-PGA) and the ATP analogue adenylyl imidophosphate (AMP-PNP) is reported. The complexed form of PGK crystallized in 2-3 d at 290 K, whereas the native form of the enzyme required 8-12 months. Morphologically, both crystal forms are similar and X-ray diffraction experiments indicate that the crystals are isomorphous. The crystals diffracted to a resolution of 2.0 A and belong to the space group P3(2). with unit-cell parameters a = b = 58.5, c = 85.4 A. [less ▲]

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See detailImpact des tiques sur la croissance des agneaux Djallonké
Hounzangbe, M. S.; Koutinhouin, G. B.; Linton, E. et al

in Annales de Médecine Vétérinaire (2001), 145

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See detailComment j'explore ... la musculature paravertebrale lombaire dans les radiculopathies par electromyographie.
Tomasella, Marco ULg; Crielaard, Jean-Michel ULg; WANG, François-Charles ULg

in Revue Médicale de Liège (2001), 56(10), 716-22

Lumbar paraspinal muscles examination is an interesting part of the electrodiagnostic evaluation of patients with suspected lumbosacral radiculopathy. However, many electromyographers hesitate to ... [more ▼]

Lumbar paraspinal muscles examination is an interesting part of the electrodiagnostic evaluation of patients with suspected lumbosacral radiculopathy. However, many electromyographers hesitate to routinely include that technique in their study of lower limbs. The purpose of this paper is to specify the anatomy and electrophysiologic data of multifidus lumbar paraspinal muscle. Previous anatomic studies indicate that the medial lumbar multifidus and lumbar interspinalis muscles share unisegmental innervation by the dorsal ram of the spinal nerve. Electromyography of these muscles can improve the sensitivity of lumbosacral radiculopathy detection. Multi-MUP analysis of quantitative electromyographic parameters in lumbar paraspinal muscles, in a population of 75 healthy subjects without back pain, allowed to set up normal values for the L5 myotome. [less ▲]

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See detailDe l'utilisation pédagogique d'Internet dans l'enseignement secondaire
Hubert, Sylviane; Petit, Christelle; Demily, Fabian et al

in Point sur la Recherche en Education (Le) (2001)

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See detailMaxbias curves of robust scale estimators based on subranges
Croux, C.; Haesbroeck, Gentiane ULg

in Metrika (2001), 53(2), 101-122

A maxbias curve is a powerful tool to describe the robustness of an estimator. It is an asymptotic concept which tells how much an estimator can change due to a given fraction of contamination. In this ... [more ▼]

A maxbias curve is a powerful tool to describe the robustness of an estimator. It is an asymptotic concept which tells how much an estimator can change due to a given fraction of contamination. In this paper, maxbias curves are computed for some univariate scale estimators based on subranges: trimmed standard deviations, interquantile ranges and the univariate Minimum Volume Ellipsoid (MVE) and Minimum Covariance Determinant (MCD) scale estimators. These estimators are intuitively appealing and easy to calculate. Since the bias behavior of scale estimators may differ depending on the type of contamination (outliers or inliers), expressions for both explosion and implosion maxbias curves are given. On the basis of robustness and efficiency arguments, the MCD scale estimator with 25% breakdown point can be recommended for practical use. [less ▲]

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See detailCalculated transition probabilities in highly charged Ti-like ions
Biémont, Emile ULg; Träbert, E.; Zeippen, C. J.

in Journal of Physics : B Atomic Molecular & Optical Physics (2001), 34

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See detailSpécificité et histoire des discours sémiotiques
Badir, Sémir ULg; Arrivé, Michel

in Linx (2001), 44

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See detailDynamique de modification de l'habitat physique de reproduction des pondeurs lithophiles sous gravier. Cas de deux frayères à ombre dans l'Aisne
Parkinson, Denis; Petit, François ULg; Houbrechts, Geoffrey ULg et al

in Bulletin de la Société Géographique de Liège (2001), 40

D’octobre 1998 à mars 1999, nous avons étudié dans l’Aisne, petit affluent ardennais de l’Ourthe, la dynamique de modification de deux bancs de gravier utilisés comme frayère par l’ombre commun en mars ... [more ▼]

D’octobre 1998 à mars 1999, nous avons étudié dans l’Aisne, petit affluent ardennais de l’Ourthe, la dynamique de modification de deux bancs de gravier utilisés comme frayère par l’ombre commun en mars-avril 1998. L’étude a été réalisée dans deux stations du cours inférieur de l’Aisne où se sont succédé quatre crues morphogènes. Dans chaque station, nous avons déterminé à intervalle d’environ 1 mois, la profondeur d’érosion et la hauteur de dépôt des sédiments (méthode de la barre d’érosion à chaînes), la granulométrie des matériaux des couches de surface et de subsurface, le dépôt des sédiments fins (placement de pièges à sédiments) et la perméabilité du substrat (méthode du standpipe). En complément, nous avons entrepris dans une station de l’Aisne moyenne, une caractérisation de divers éléments de la dynamique fluviale : identification des débits mobilisateurs (par marquage colorimétrique des sédiments en place), estimation de la vitesse de déplacement de la charge de fond (par étude de la dispersion longitudinale de scories, résidu d’anciennes industries métallurgiques) et estimation des quantités de sédiments charriés par la rivière (à partir des données de dragage). [less ▲]

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See detailEvolution des organisations urbaines et mobilités quotidiennes : espace de référence et analyse des processus
Halleux, Jean-Marie ULg

in Espace Géographique (L') (2001), 30(1), 67-80

Cet article traite des liens entre la mobilité quotidienne et les évolutions intra-urbaines. Dans ce cadre, un espace géographique urbain de référence a tout d'abord été construit ; afin de clarifier des ... [more ▼]

Cet article traite des liens entre la mobilité quotidienne et les évolutions intra-urbaines. Dans ce cadre, un espace géographique urbain de référence a tout d'abord été construit ; afin de clarifier des processus d'évolution, il semble en effet naturel de débuter par la définition d'un état stable. Concernant les processus, plusieurs différenciations ont été opérées, notamment : l'urbanisation par rapport à la désurbanisation et l'urbanisation fonctionnelle par rapport à l'urbanisation morphologique. La problématique des types de mobilité a également été intégrée, ce qui a déterminé une réflexion sur le thème de la transition périurbaine, c'est-à-dire le processus de mutation de la ville sous l'impact de la mobilité automobile. [less ▲]

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See detailOn the exact solutions of the Lipkin-Meshkov-Glick model
Debergh, N.; Stancu, Floarea ULg

in Journal of Physics : A Mathematical & General (2001), A34

We present the many-particle Hamiltonian model of Lipkin, Meshkov and Glick in the context of deformed polynomial algebras and show that its exact solutions can be easily and naturally obtained within ... [more ▼]

We present the many-particle Hamiltonian model of Lipkin, Meshkov and Glick in the context of deformed polynomial algebras and show that its exact solutions can be easily and naturally obtained within this formalism. The Hamiltonian matrix of each $j$ multiplet can be split into two submatrices associated to two distinct irreps of the deformed algebra. Their invariant subspaces correspond to even and odd numbers of particle-hole excitations. [less ▲]

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See detailPharmacology of the Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor Bm-531
Dogné, J. M.; Rolin, S.; de Leval, X. et al

in Cardiovascular Drug Reviews (2001), 19(2, Summer), 87-96

BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its ... [more ▼]

BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its affinity for human washed platelet TXA2 receptors labeled with [3H]SQ-29548 (IC50 = 0.0078 microM) is higher than sulotroban (IC50 = 0.93 microM) and SQ-29548 (IC50 = 0.021 microM). Moreover, BM-531 is characterized by a potent antiaggregatory property. Indeed, on one hand, in human citrated platelet-rich plasma BM-531 prevents platelet aggregation induced by arachidonic acid (600 microM) (ED100 = 0.125 microM), U-46619, a stable TXA2 agonist (1 microM) (ED50 = 0.482 microM) or collagen (1 microgram/mL) (percentage of inhibition: 42.9% at 10 microM) and inhibits the second wave of ADP (2 microM)-induced aggregation. On the other hand, when BM-531 is incubated in whole blood from healthy donors, the closure time measured by the recently developed platelet function analyser (PFA-100) is significantly prolonged. In addition, at the concentrations of 10 and 1 microM, BM-531 totally prevents the production of TXB2 by human platelets activated by arachidonic acid. Finally, at 10 microM, BM-531 significantly prevents rat fundus contractions induced by U-46619 but not by prostacyclin. These results suggest that BM-531, which is devoid of the diuretic property of torasemide, can be regarded as a promising antiplatelet agent. [less ▲]

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See detailInteractions between systemic analgesics.
Joris, Jean ULg; Kaba, Abdourahmane ULg

in Acta Anaesthesiologica Belgica (2001), 52(4), 395-401

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See detailOptimisation of Stiffened Structures
Rigo, Philippe ULg

in Dept. of Naval Architecture and Marine Engineering (2001)

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See detailPalynology and sedimentology of laminites and tillites from the latest Famennian of the Parnaíba Basin, Brazil.
Streel, Maurice ULg; Caputo, M.V.; Loboziak, S et al

in Geologica Belgica (2001), 3(1-2), 87-96

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See detailThe role of the Technical Barrier to Trade Agreement in the development of transparency
Munoz, Rodolphe ULg

in Cambridge Yearbook of European Legal Studies (2001), 4

Cet article vise à donner une explication générale du fonctionnement de l'accord OTC. Il s'attarde plus particulièrement sur les aspects concernant le contrôles des barrières techniques au commerce. En ... [more ▼]

Cet article vise à donner une explication générale du fonctionnement de l'accord OTC. Il s'attarde plus particulièrement sur les aspects concernant le contrôles des barrières techniques au commerce. En effet, celles-ci sont aujourd'hui les plus entraventes pour les entreprises. [less ▲]

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See detailComparison by image processing of target supports of spray droplets
Degre, Aurore ULg; Mostade, Olivier; Huyghebaert, Bruno et al

in transaction of the American society of Agricultural engineers (2001), 44(2), 217-222

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See detailRecommandations de l’association d’épidémiologie et de santé animale concernant la lutte contre la rhinotrachéite infectieuse bovine (IBR) en Belgique
Limbourg, B.; Kerkhofs, P.; Massard, C. et al

in Annales de Médecine Vétérinaire (2001), 147

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See detailPractical Aspects Of Computational Chemistry Calculations Through Pc Networks: The Ramses-Beowulf Implementation
Beuve-Mery, D.; Rahman, M.; Ducarme, P. et al

in Journal of Computational Chemistry (2001), 22(2), 172-7

We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our ... [more ▼]

We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our experience and discuss our choices. The architecture is composed of Pentium processors connected by a 100 Mbits/s Ethernet network. Because RAMSES are built of independent computers, the system is easily maintained, and can be modified by adding or removing machines. Two programs, which are dedicated to molecular modeling and were previously developed on single machines (OSIRIS and IMPALA), have been adapted. IMPALA models peptide and protein interaction with membranes, OSIRIS simulates an ab initio folding of globular proteins. After parallelization, each program consists of two parts: one is the human/RAMSES interface, and the second is the simulation per se. The parallel architecture is transparent for the users. Tests of the IMPALA and OSIRIS efficiencies are shown and discussed. [less ▲]

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See detailUnimolecular reaction dynamics from kinetic energy release distributions. 8. Protonated fluorobenzene and structure of the phenyl ion
Lorquet, Jean-Claude ULg; Lorquet, Andrée

in Journal of Physical Chemistry A (2001), 105(15), 3719-3724

A previous interpretation of the kinetic energy release distribution (KERD) observed in the fragmentation of protonated fluorobenzene is confirmed by a maximum entropy analysis. The KERD is bimodal, with ... [more ▼]

A previous interpretation of the kinetic energy release distribution (KERD) observed in the fragmentation of protonated fluorobenzene is confirmed by a maximum entropy analysis. The KERD is bimodal, with an intense and broad component due to the production of the cyclic phenyl ion. Ab initio calculations indicate the existence of several open-chain isomers, with an energy about 1.0-1.2 eV higher than that of the phenyl ring. A weaker component of the KERD corresponds to the formation of one or several of these acyclic structures. Its abundance represents about 6% of the main component (but drops down to 3% for the perdeuterated isomer). More translational energy than the statistical estimate is released during the dissociation process because of the presence of a barrier along the reaction path leading to the generation of the cyclic phenyl ion. About one-half of the energy of the barrier is released as translation, thereby indicating the operation of strong exit-channel interactions between separating fragments. © 2001 American Chemical Society. [less ▲]

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See detailLes techniques d'empreinte en implantologie
Van Heusden, Alain ULg

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (2001), 56(3), 189-203

The implant-borne prostheses have become an integral part of the oral rehabilitation procedures. The aim of this article is to describe the most current impression techniques for oral implant prosthetics ... [more ▼]

The implant-borne prostheses have become an integral part of the oral rehabilitation procedures. The aim of this article is to describe the most current impression techniques for oral implant prosthetics used at the University of Liege, Belgium. Impression protocols adapted to various prosthetic procedures are described step-by-step through several clinical cases. Emphasis is put on the means necessary for achieving a precise adaptation and a passive fit of the final prosthetic suprastructure. [less ▲]

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See detailDendritic cells induce the death of human papillomavirus-transformed keratinocytes
Hubert, Pascale ULg; Giannini, Sandra ULg; Vanderplasschen, Alain ULg et al

in FASEB Journal (2001), 15(13), 2521-2523

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See detailUn nouveau projet archéologique de l'Université de Lyon 2.
Morard, Thomas ULg; Wavelet, David

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2001), 113(1), 477-481

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See detailEmissions gazeuses en élevage porcin et modes de réduction : revue bibliographique
Degre, Aurore ULg; Verheve, Didier; Debouche, Charles ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(3), 135-143

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See detailConsumer Evaluations of Brand Extensions: Differences between Goods and Services
Van Riel, Allard ULg; Lemmink, Jos; Ouwersloot, Hans

in Journal of Service Research (2001), 3(3), 220-231

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See detailLes configurations de risques comme approche de la résilience dans une étude longitudinale
Boët, S.; Born, Michel ULg

in Revue Québécoise de Psychologie (2001), 22(1), 93-116

Cette recherche s'inscrit dans le cadre d'une étude longitudinale des facteurs de risque et de protection en délinquance juvénile. Nous avons observé les pratiques éducatives de la mère ainsi que le ... [more ▼]

Cette recherche s'inscrit dans le cadre d'une étude longitudinale des facteurs de risque et de protection en délinquance juvénile. Nous avons observé les pratiques éducatives de la mère ainsi que le comportement de l'enfant de sa naissance à cinq ans. Nous avons pu mettre en évidence quatre configurations de risque familial qui s'avèrent contenir nombre des enfants les plus turbulents de notre échantillon. Cependant, ces configurations rassemblent aussi des enfants qui ne manifestent aucun trouble comportemental, ce sont des enfants que nous considérons comme résilients. [less ▲]

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See detailCore-shell-corona micelles with a responsive shell
Gohy, Jean-François; Willet, Nicolas ULg; Varshney, Sunil et al

in Angewandte Chemie (International ed. in English) (2001), 40(17), 3214-3216

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See detailSome properties of generalized age-distribution equations in fluid dynamics
Beckers, Jean-Marie ULg; Delhez, Eric ULg; Deleersnijder, Eric

in SIAM Journal on Applied Mathematics (2001), 61(5), 1526-1544

The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry ... [more ▼]

The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry properties arise for the age field. In particular, for a point release, the age field is isotropic, regardless of the direction of the ow and the value of the diffusion coefficient. The analysis is then extended to situations with time-varying currents, where the symmetry can be broken under some circumstances. Finally, we show a method by which a time-dependent problem can be used to assess a stationary concentration distribution function, providing details about the propagation of younger and older material at a given location. [less ▲]

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