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See detailVascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas.
Munaut, Carine ULiege; Noël, Agnès ULiege; Hougrand, Olivier ULiege et al

in International Journal of Cancer = Journal International du Cancer (2003), 106(6), 848-55

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of ... [more ▼]

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors (VEGFR-1, its soluble form sVEGFR-1, VEGFR-2 and neuropilin-1) are expressed predominantly by endothelial cells. Infiltrating tumour cells and newly-formed capillaries progress through the extracellular matrix by local proteolysis involving matrix metalloproteinases (MMPs). Recent studies have shown that VEGF expression and bioavailability can be modulated by MMPs. We reported previously that the expression of MT1-MMP in human breast cancer cells was associated with an enhanced VEGF expression. We used quantitative RT-PCR, Western blot, gelatin zymography and immunohistochemistry to study the expression of VEGF, VEGFR-1, VEGFR-2, sVEGFR-1, neuropilin-1, MT1-MMP, MMP-2, MMP-9 and TIMP-2 in 20 human GBMs and 5 normal brains. The expression of these MMPs was markedly increased in most GBMs with excellent correlation between mRNA and protein levels; activated forms of MMP-2 and MMP-9 were present in 8/18 and 7/18 of GBMs. A majority of GBMs (17/20) also expressed high levels of VEGF, as previously reported, with strong correlation between VEGF and MT1-MMP gene expression levels, and double immunostaining showed that VEGF and MT1-MMP peptides co-localize in tumour and endothelial cells. Our results suggest that the interplay between metalloproteinases and VEGF previously described in experimental tumours may also be operative in human GBMs. Because of its dual ability to activate MMP-2 and to up-regulate VEGF, MT1-MMP might be of central importance in the growth of GBMs and represent an interesting target for anti-cancer treatments. [less ▲]

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See detailToward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides
De Tullio, Pascal ULiege; Becker, B.; Boverie, S. et al

in Journal of Medicinal Chemistry (2003), 46

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See detailOn the influence of aluminium and silicon contents on the kinetics of bainite transformation of intercritical austenite
Mertens, Anne ULiege; Jacques, Pascal J.; Zhao, Lie et al

in Journal de Physique IV (2003), 112

TRIP-assisted steels show enhanced mechanical properties thanks to the strain-induced transformation of retained austenite to martensite (TRIP effect). Stabilisation of austenite is made possible by the ... [more ▼]

TRIP-assisted steels show enhanced mechanical properties thanks to the strain-induced transformation of retained austenite to martensite (TRIP effect). Stabilisation of austenite is made possible by the combination of appropriate chemical composition (containing classically high levels of silicon, or, as developed more recently, aluminium) and of a two-steps heat treatment comprising an intercritical annealing followed by an isothermal holding in the bainite formation range. A detailed understanding of the effects of both elements on the bainite transformation kinetics is thus of primary importance for the optimisation of austenite retention. The present study aims at a better knowledge of the influence of aluminium levels on the kinetics of the bainite transformation of intercritical austenite, as compared to the effect of silicon. The bainite transformation kinetics was followed by dilatometry in a set of 6 steel grades with varying aluminium and silicon contents. These dilatometry experiments were coupled with a characterisation of the microstructures by X-ray diffraction, SEM and image analysis. It was shown that aluminium has a less pronounced effect than silicon in retarding the bainite transformation [less ▲]

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See detailResponse of coccolithophorid Emiliania huxleyi to elevated partial pressure of CO2 under nitrogen limitation
Sciandra, A.; Harlay, Jérôme ULiege; Lefevre, D. et al

in Marine Ecology. Progress Series (2003), 261

Precipitation of calcium carbonate by phytoplankton in the photic oceanic layer is an important process regulating the carbon cycling and the exchange Of CO2 at the ocean-atmosphere interface. Previous ... [more ▼]

Precipitation of calcium carbonate by phytoplankton in the photic oceanic layer is an important process regulating the carbon cycling and the exchange Of CO2 at the ocean-atmosphere interface. Previous experiments have demonstrated that, under nutrient-sufficient conditions, doubling the partial pressure Of CO2 (pCO(2)) in seawater-a likely scenario for the end of the century-can significantly decrease both the rate of calcification by coccolithophorids and the ratio of inorganic to organic carbon production. The present work investigates the effects of high pCO(2) on calcification by the coccolithophore Emiliania huxleyi (Strain TW1) grown under nitrogen-limiting conditions, a situation that can also prevail in the ocean. Nitrogen limitation was achieved in NO3-limited continuous cultures renewed at the rate of 0.5 d(-1) and exposed to a saturating light level. pCO(2) was increased from 400 to 700 ppm and controlled by bubbling CO2-rich or CO2-free air into the cultures. The pCO(2) shift has a rapid effect on cell physiology that occurs within 2 cell divisions subsequent to the perturbation. Net calcification rate (C) decreased by 25% and, in contrast to previous studies with N-replete cultures, gross community production (GCP) and dark community respiration (DCR) also decreased. These results suggest that increasing pCO(2) has no noticeable effect on the calcification/photosynthesis ratio (C/P) when cells of E. huxleyi are NO3-limited. [less ▲]

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See detailShortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups
Bosset, J. F.; Roelofsen, F.; Morgan, D. A. L. et al

in European Journal of Cancer (2003), 39

Abstract The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined radiochemotherapy is the standard treatment for locally advanced anal ... [more ▼]

Abstract The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined radiochemotherapy is the standard treatment for locally advanced anal cancer. This EORTC phase II study (#22953) tests the feasibility of reducing the gap between sequences to 2 weeks, to deliver Mitomycin C (MMC) in each radiotherapy sequence and 5-FU continuously during the treatment. The first sequence consisted of 36 Gy over 4 weeks. 5-FU 200 mg/m2/days 1–26, MMC 10 mg/m2/day 1 gap 16 days. Then a second sequence of 23.4 Gy over 17 days, 5-FU 200 mg/m2/days 1–17 and, MMC 10 mg/m2/day 1 was given. 43 patients with a World Health Organization (WHO) status of 0 (n=27) or 1 (n=16) and with T2-T4, N0-3 tumours were included. Compliance with the planned treatment, doses and duration was 93%. The complete response rate was 90.7%. Grade 3 toxicities of 28, 12 and 2% were observed for skin, diarrhoea and haematological toxicities, respectively. The 3-year estimated rates for trials 22861 and 22953 are: 68 and 88% for local control; 72 and 81% for colostomy-free interval, 62 and 84% for severe late toxicity-free interval, and 70 and 81% for survival, respectively. The 22953 scheme is feasible and the results are promising. This is now considered as the new standard scheme by the EORTC. [less ▲]

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See detailNombres et jeux enfantins
Lempereur, Françoise ULiege

in Enquêtes du Musée de la Vie Wallonne (2003), XX

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ... [more ▼]

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ethnomusicologist Constantin Brailoiu [less ▲]

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See detailA time–frequency technique for the stability analysis of impulse responses from nonlinear aeroelastic systems
Dimitriadis, Grigorios ULiege; Cooper, Jonathan E

in Journal of Fluids & Structures (2003), 17(8), 11811201

A time–frequency method is proposed for the analysis of response time histories from nonlinear aeroelastic systems. The approach is based on a time-varying curve-fit of the short time Fourier transform of ... [more ▼]

A time–frequency method is proposed for the analysis of response time histories from nonlinear aeroelastic systems. The approach is based on a time-varying curve-fit of the short time Fourier transform of the impulse response. It is shown that the method can be used in order to obtain a clear picture of the sub-critical stability of a number of aeroelastic systems with a variety of structural and aerodynamic nonlinearities. Additionally, frequency and amplitude information can be obtained for both the linear and nonlinear signatures of the response signals in the sub- and postcritical regions. Finally, it is shown that, given certain types of nonlinear functions, sub-critical damping trends can be extrapolated to predict bifurcation airspeeds. [less ▲]

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See detailp-mode Oscillations of alpha Cen A
Thoul, Anne ULiege; Scuflaire, Richard ULiege; Vatovez, B. et al

in Astrophysics & Space Science (2003), 284

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (2002) and the data derived from the spectroscopic analysis of Neuforge and Magain (1997). The seismological ... [more ▼]

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (2002) and the data derived from the spectroscopic analysis of Neuforge and Magain (1997). The seismological data obtained by Bouchy and Carrier (2001, 2002) do help improve our knowledge of the evolutionary status of the system. All the constraints are satisfied with a model which gives an age of about 6 Gyr for the binary. [less ▲]

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See detailSeismic triggering of landslides. Part B: Simulation of dynamic failure processes
Havenith, Hans-Balder ULiege; Strom, A.; Calvetti, F. et al

in Natural Hazards & Earth System Sciences (2003), 3

From field observations it is possible to establish correlations between geological conditions and landslide occurrence. However, in general, it is difficult to assess the affect of individual factors on ... [more ▼]

From field observations it is possible to establish correlations between geological conditions and landslide occurrence. However, in general, it is difficult to assess the affect of individual factors on slope instability because of their mutual interaction. In addition, the dynamic effect of propagating seismic waves significantly increases the complexity of the slope stability problem. Wave diffraction, reflection and focusing effects are dependent on local geological conditions and make it difficult to analyse dynamic sliding mechanisms using field observations alone. As a consequence, in order to examine the influence of various geological and seismic factors on slope movements, it is often necessary to produce numerical models. This paper describes the results of such models as applied to two case studies in Kyrgyzstan: the Ananevo rockslide, located in granite, and the Suusamyr debris slump-flow, situated within soft sediments (see Part A: Havenith et al., 2003). Discrete element modelling (UDEC), adapted both to the discontinuous character of fractured rock and to the heterogeneity of layered mediums, was used. This permitted simulation of deformation mechanisms, including seismically induced bending, block tilting, and slip. Particular attention was paid to the interaction between deformation mechanisms, site-specific amplification effects, and subsurface structure. [less ▲]

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See detailFoam imbibition in microgravity - An experimental study
Caps, Hervé ULiege; Decauwer, H.; Chevalier, M. L. et al

in European Physical Journal B -- Condensed Matter (2003), 33(1), 115-119

We report an experimental study of aqueous foam imbibition in microgravity with strict mass conservation. The foam is in a Hele-Shaw cell. The bubble edge width l is measured by image analysis. The ... [more ▼]

We report an experimental study of aqueous foam imbibition in microgravity with strict mass conservation. The foam is in a Hele-Shaw cell. The bubble edge width l is measured by image analysis. The penetration of the liquid in the foam, the foam imbibition, the foam inflation, and the rigidity loss are shown all to obey strict diffusion processes. The motion of bubbles needed for the foam inflation is a slow two-dimensional process with respect to the one-dimensional capillary rise of liquid. The foam is found to imbibes faster than it inflates. [less ▲]

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See detailTierce décision obligatoire et motivation
Caprasse, Olivier ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailComment j'explore ... la cinetique glycemique des patients diabetiques par monitoring continu du glucose interstitiel.
Radermecker, Régis ULiege; Magis, Delphine ULiege; Selam, J. L. et al

in Revue Médicale de Liège (2003), 58(3), 164-7

The improvement of diabetic patients' glycaemic status requires an increase of fingerstick blood glucose measurements. Among the possibilities available to assess diabetes' control, we will consider new ... [more ▼]

The improvement of diabetic patients' glycaemic status requires an increase of fingerstick blood glucose measurements. Among the possibilities available to assess diabetes' control, we will consider new systems of continuous interstitial glucose monitoring. After a brief description of the devices presently commercialized, we will discuss their indications and their limitations, as well as their future prospects in a possible "closed loop" insulin delivery according to blood glucose level. [less ▲]

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See detailTierce décision obligatoire et violation d'une règle de procédure conventionnellement arrêtée par les parties
Caprasse, Olivier ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailL’herpèsvirus bovin 4
Markine-Goriaynoff, N.; Minner, F.; De Fays, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 215-247

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a ... [more ▼]

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a worldwide distribution in the cattle population. It has been isolated from cattle showing various clinical signs as well as from healthy cattle. The interest of the scientific community for BoHV-4 is explained by two reasons. Firstly, BoHV-4 represents an homologous virus/host species model to study the biology of gammaherpesviruses. Secondly, the use of BoHV-4 as a recombinant vector for expression both in vitro and in vivo has been proposed. For these reasons, a considerable amount of data has been collected on this virus. In the present paper, the authors will present a general overview of the literature published on this virus addressing clinical, epidemiological and fundamental aspects of BoHV-4. Finally, in the light of their recent phylogenetic data, the authors will discuss the origin and the host species of BoHV-4 leading to the conclusion that this virus should be considered as a virus of the African buffalo rather than cattle. [less ▲]

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See detailLa responsabilité extra-contractuelle des dirigeants de sociétés
Caprasse, Olivier ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailInteraction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Twizere, Jean-Claude ULiege; Kruys, Veronique; Lefebvre, Laurent et al

in Journal of the National Cancer Institute (2003), 95(24), 1846-59

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell ... [more ▼]

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell leukemia viruses and bovine leukemia virus). To better understand the molecular pathways leading to cell transformation, we aimed to identify cellular proteins interacting with Tax. METHODS: We used a yeast two-hybrid system to identify interacting cellular proteins. Interactions between Tax and candidate interacting cellular proteins were confirmed by glutathione S-transferase (GST) pulldown assays, co-immunoprecipitation, and confocal microscopy. Functional interactions between Tax and one interacting protein, tristetraprolin (TTP), were assessed by analyzing the expression of tumor necrosis factor-alpha (TNF-alpha), which is regulated by TTP, in mammalian cells (HeLa, D17, HEK 293, and RAW 264.7) transiently transfected with combinations of intact and mutant Tax and TTP. RESULTS: We obtained seven interacting cellular proteins, of which one, TTP, was further characterized. Tax and TTP were found to interact specifically through their respective carboxyl-terminal domains. The proteins colocalized in the cytoplasm in a region surrounding the nucleus of HeLa cells. Furthermore, coexpression of Tax was associated with nuclear accumulation of TTP. TTP is an immediate-early protein that inhibits expression of TNF-alpha at the post-transcriptional level. Expression of Tax reverted this inhibition, both in transient transfection experiments and in stably transfected macrophage cell lines. CONCLUSION: Tax, through its interactions with the TTP repressor, indirectly increases TNF-alpha expression. This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis. [less ▲]

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See detailMolecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition.
Blott, Sarah; Kim, Jong-Joo; Moisio, Sirja et al

in Genetics (2003), 163(1), 253-66

We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome ... [more ▼]

We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population. [less ▲]

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See detailReview of James Procter's Dwelling Places: Postwar Black British Writing
Ledent, Bénédicte ULiege

in Moving Worlds : A Journal of Transcultural Writings (2003), 3(2), 138-139

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See detailCalculation of bovine haemoglobin oxygen saturation by algorithms integrating age, haemoglobin content, blood pH, partial pressures of oxygen and carbon dioxide in the blood, and temperature.
Detry, Benoit; Cambier, Carole ULiege; Frans, A. et al

in Veterinary Journal (2003), 165(3), 258-265

In human and veterinary medicine, arterial and venous haemoglobin oxygen saturations are often used to estimate the severity of a disease and to guide therapeutic decisions. In veterinary medicine ... [more ▼]

In human and veterinary medicine, arterial and venous haemoglobin oxygen saturations are often used to estimate the severity of a disease and to guide therapeutic decisions. In veterinary medicine, haemoglobin oxygen saturation (SO(2)) is usually calculated using a blood gas analyser and algorithms developed for humans. It is possible, therefore, that the values obtained in animals may be distorted, particularly in animals with a high haemoglobin oxygen affinity, like young calves. In order to verify this hypothesis, we compared the arterial (SaO(2)) and venous (SvO(2)) haemoglobin oxygen saturations calculated using three different algorithms, and the oxygen exchange fraction (OEF) at the tissue level, which is the degree of haemoglobin desaturation between arterial and venous blood (SaO(2)-SvO(2)), with the values obtained from the whole bovine oxygen equilibrium curve (OEC) determined by a reference method. The blood gas analysers underestimated SvO(2) values; consequently, the OEF was overestimated (by about 10%). Two methods of reducing these errors were assessed. As the haemoglobin oxygen affinity decreases during the first month of life in calves a relationship between PO(2) at 50% haemoglobin saturation (P50) and age was established in order to correct the calculated values of venous and arterial SO(2), taking into account the estimated position of the OEC. This method markedly reduced the error for SvO(2) and OEF. Secondly, the SO(2) was calculated using a mathematical model taking into account the age of the animal and the specific effects of pH, PCO(2), and temperature on the bovine OEC. Using this method, the mean difference between the OEF values calculated using the mathematical model and those calculated by the reference method was close to zero. The errors produced by blood gas analysers can thus be minimised in two ways: firstly, by simply introducing a P50 estimated from the age of the calf into the analyser before the measurement; and secondly, by calculating the SO(2) using a mathematical model applied to the bovine OEC. [less ▲]

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See detailUse of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses.
Van Erck, Emmanuelle ULiege; Votion, Dominique ULiege; Kirschvink, Nathalie et al

in American Journal of Veterinary Research (2003), 64(11), 1414-1420

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses ... [more ▼]

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses. ANIMALS: 10 horses (4 healthy; 6 with recurrent airway obstruction [heaves] in remission). PROCEDURE: Healthy horses (group-A horses) and heaves-affected horses (group-B horses) were housed in a controlled environment. At each step of a methacholine bronchoprovocation test, threshold concentration (TC(2SD); results in a 2-fold increase in SD of a value) and sensitivity index (SI) were determined for respiratory tract system resistance (R(rs)) and respiratory tract system reactance (X(rs)) at 5 to 20 Hz by use of IOS and for total pulmonary resistance (RL) and dynamic lung compliance (C(dyn)), by use of CRT. RESULTS: Bronchoconstriction resulted in an increase in R(rs) at 5 Hz (R(5Hz)) and a decrease in X(rs) at all frequencies. Most sensitive parameters were X(rs) at 5 Hz (X(5Hz)), R(5Hz), and R(5Hz):R(10Hz) ratio; RL and the provocation concentration of methacholine resulting in a 35% decrease in dynamic compliance (PC(35)C(dyn)) were significantly less sensitive than these IOS parameters. The TC(2SD) for X(rs) at 5 and 10 Hz was significantly lower in group-B horses, compared with group-A horses. The lowest TC(2SD) was obtained for X(5Hz) in group-B horses and R(5Hz) in group-A horses. CONCLUSIONS AND CLINICAL RELEVANCE: In contrast to CRT parameters, IOS parameters were significantly more sensitive for testing pulmonary function.The IOS provides a practical and noninvasive pulmonary function test that may be useful in assessing subclinical changes in horses. [less ▲]

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See detailVolumen-Flussmessung mit "Colour Velocity Imaging (CVI)": Technik der Messung in der intrahepatischen fetalen Vena umbilicalis
Chantraine, Frédéric ULiege; Reihs, Tanja; Henrich, Wolfgang et al

in Zentralblatt für Gynakologie (2003), 125

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See detailUtilisation du tableur Excel pour le remboursement d'un emprunt par une annuité
Henry, Valérie ULiege; Coolen, Annette ULiege

in Mathématique et Pédagogie (2003), 143

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See detailTreatment failures and relapses in onychomycosis: a stubborn clinical problem.
Arrese Estrada, Jorge ULiege; Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 207(3), 255-60

The therapeutic outcome of onychomycoses is uncertain. Comparative short-term efficacy studies on antifungals abound and report contradictory findings. Few unbiased follow-up studies have scrutinized the ... [more ▼]

The therapeutic outcome of onychomycoses is uncertain. Comparative short-term efficacy studies on antifungals abound and report contradictory findings. Few unbiased follow-up studies have scrutinized the long-term outcome. Basically, none of the current antifungals can guarantee cure in all instances. In addition, relapses are not rare. The causes of therapeutic failure in onychomycoses are multiple. The most important are the lack of diagnostic accuracy, inadequate antifungal choice or delivery modality, and presence of dormant conidia, sequestrated mycelium pockets or resistant fungal species. The concept of fungicidal drug derived from selected in vitro studies appears irrelevant in clinical practice. [less ▲]

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See detailPrincipal component analysis of Piezo-Sensor Array for damage localization
De Boe, Pascal; Golinval, Jean-Claude ULiege

in Structural Health Monitoring (2003), 2(2), 137-144

This paper focuses on applying statistical process control techniques, based on principal component analysis, to vibration-based damage diagnosis. It is well known that localized structural damages with ... [more ▼]

This paper focuses on applying statistical process control techniques, based on principal component analysis, to vibration-based damage diagnosis. It is well known that localized structural damages with relative small amplitude do not affect much the global modal response of the structure, at least at low frequencies. Nevertheless, it can be expected that the local dynamic behavior of a damaged structural subcomponent is significantly affected. Assuming that each structural subcomponent is monitored, local structural damage, with relative small amplitude, will only affect a particular sensor without affecting significantly the response of the others. By applying a principal component analysis on the sensor time responses, it is possible to see that any change of one particular sensor will affect the subspace spanned by the complete sensor response set. The subspace corresponding to the damaged structure can then be compared with the subspace of an initial state in order to diagnose possible damage. The principal component analysis may also be performed for every potential subset of damaged sensors in order to identify the involved sensor, and, therefore, the damaged structural component. The spatial information given by the distributed sensors (e.g. piezoelectric laminates) can be used to forecast structural damages on a critical area but damage localization is also possible with classical sensors (e.g. accelerometers). The damage may be located as the errors attain the maximum at the sensors instrumented in the damaged substructures. [less ▲]

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See detailSylviculture et qualité du bois de l'épicéa en Région wallonne
Hebert, Jacques ULiege; Herman, Marc; Jourez, Benoît ULiege

in Forêt Wallonne (2003), 62

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Delarge, J. et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003)

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See detailDroits de l'homme et nationalité
Carlier, Jean-Yves ULiege

in Annales de Droit de Louvain (2003), 63(3), 243-257

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See detailInvestigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry
Pochet, L.; Dieu, M.; Frederick, R. et al

in Tetrahedron (2003)

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See detailNitric oxide and cardiac function: ten years after, and continuing.
MASSION, Paul ULiege; Feron, O.; Dessy, C. et al

in Circulation Research (2003), 93(5), 388-98

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The former include regulation ... [more ▼]

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The former include regulation of coronary vessel tone, thrombogenicity, and proliferative and inflammatory properties as well as cellular cross-talk supporting angiogenesis. The latter comprise the direct effects of NO on several aspects of cardiomyocyte contractility, from the fine regulation of excitation-contraction coupling to modulation of (presynaptic and postsynaptic) autonomic signaling and mitochondrial respiration. This multifaceted involvement of NO in cardiac physiology is supported by a tight molecular regulation of the three NO synthases, from cellular spatial confinement to posttranslational allosteric modulation by specific interacting proteins, acting in concert to restrict the influence of NO to a particular intracellular target in a stimulus-specific manner. Loss of this specificity, such as produced on excessive NO delivery from inflammatory cells (or cytokine-stimulated cardiomyocytes themselves), may result in profound cellular disturbances leading to heart failure. Future therapeutic manipulations of cardiac NO synthesis will necessarily draw on additional characterization of the cellular and molecular determinants for the net effect of this versatile radical on the cardiomyocyte biology. [less ▲]

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULiege et al

in Acta Crystallographica (2003)

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See detail1s2s2p(2)3s 6P - 1s2p(3)3s 6S° transitions in OIV
Lin, B.; Berry, H. G.; Shibata, T. et al

in Physical Review. A (2003), 67

The energies and lifetimes of doubly excited sextet states of boron-like O IV, F V, and Ne VI are calculated with the multiconfiguration Hartree-Fock approach, including QED and higher-order corrections ... [more ▼]

The energies and lifetimes of doubly excited sextet states of boron-like O IV, F V, and Ne VI are calculated with the multiconfiguration Hartree-Fock approach, including QED and higher-order corrections, and also with the multiconfiguration Dirac-Fock GRASP code. The wavelengths and transition rates of electric-dipole transitions from the inner-shell excited terms 1s2s2p23s 6P–1s2p33s 6So are investigated by beam-foil spectroscopy in the XUV spectral region. The predicted transition wavelengths agree with the experiment. The higherorder corrections, fine structures, and spectrum with high wavelength resolution are found to be critically important in these comparisons. Nine new lines have been identified. The ground sextet states of boronlike atoms are metastable and well above several ionization levels. These are possible candidates for XUV and soft x-ray lasers. [less ▲]

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See detailLa climatologie
Erpicum, Michel ULiege; Alexandre, Jean ULiege

in Bulletin de la Société Géographique de Liège (2003), 43(2003), 79-88

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See detailImpact of medical specialist' locus of control on communication skills in oncological interviews
Libert, Y.; Janne, P.; Razavi, D. et al

in British Journal of Cancer (2003), 88

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See detailRecognizing and interpreting the fossils of early eukaryotes
Javaux, Emmanuelle ULiege; Knoll, A. H.; Walter, M.

in Origins of Life & Evolution of the Biosphere (2003), 33(1), 75-94

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context ... [more ▼]

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context of early eukaryotic diversification. For this reason, recognition of eukaryotic fossils in Proterozoic rocks is key to the integration of geological and comparative biological perspectives on protistan evolution. Microfossils preserved in shales of the ca. 1500 Ma Roper Group, northern Australia, display characters that ally them to the Eucarya, but, at present, attribution to any particular protistan clade is uncertain. Continuing research on wall ultrastructure and microchemistry promises new insights into the nature and systematic relationships of early eukaryotic fossils. [less ▲]

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See detailEstimation of habitat quality based on plant community, and effects of isolation in a network of butterfly habitat patches
Sawchik, J.; Dufrêne, Marc ULiege; Lebrun, Philippe

in Acta Oecologica (2003), 24(1), 25-33

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ... [more ▼]

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ecological network for five butterfly species (Brenthis ino, Clossiana selene, Lycaena helle, Lycaena hippothoe, Proclossiana eunomia) inhabiting wet meadows. Abundance predictions were performed on the basis of botanical relevés with a multiple-species approach combining canonical correspondence analysis and multiple regression. Models are defined on a reference site set and are evaluated on a test site set. All the fitted models predicted the abundance of the butterfly species considerably well (from 61 to 86% of the variation). We evaluated the potential consequences of isolation on local populations, by comparing predicted and observed abundance. It was expected that greater differences would be observed when sites were more isolated. On the test set, differences between predicted and observed abundance were largely correlated to site isolation for L. helle and P. eunomia. The most isolated sites had greater chances to be empty, even if they had high-quality habitat. Reciprocally, when the sites were less isolated, the abundance observed was always greater than predicted, seeming to confirm the role of rescue effects. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. [less ▲]

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See detailCompte-rendu de "La parola al testo. Scritti per Bice Mortara Garavelli"
Benzoni, Pietro ULiege

in Stilistica e metrica italiana (2003), III(3), 316-320

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULiege; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

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See detailChromomycose autochtone chez une patiente immunodéprimée.
Quatresooz, Pascale ULiege; Dethier, F.; Pierard, Gérald ULiege

in Dermatologie Actualité (2003), 74

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See detailEffect of histamine on lung contractile elements in growing cattle
Jolly, Sandra ULiege; Robinson, Edward; Desmecht, Daniel ULiege

in American Journal of Veterinary Research (2003), 64

OBJECTIVE: To determine the effect of histamine on the contractile elements of the respiratory tract in neonatal calves and young adult cattle. SAMPLE POPULATION: Samples of trachealis muscle, bronchi ... [more ▼]

OBJECTIVE: To determine the effect of histamine on the contractile elements of the respiratory tract in neonatal calves and young adult cattle. SAMPLE POPULATION: Samples of trachealis muscle, bronchi, and intrapulmonary arteries and veins dissected from the respiratory tracts of healthy bovids (2 to 8 days and 16 to 20 months old). PROCEDURE: Histamine cumulative concentration-effect curves (10(-6) to 10(-3) M) were constructed in duplicate smooth muscle samples mounted in organ baths. Contractile responses to histamine were compared with reference contractions elicited by methacholine (10(-5) M) for airways or KCl (127 mM) for vessels. RESULTS: In young adult cattle, trachealis muscle had a substantial contractile response to histamine (84% of methacholine-induced contraction), whereas bronchi reacted slightly (15 and 20% for large and small bronchi, respectively). Although contractile responses to KCl were comparable in arteries and veins, histamine-induced contractions were greater for intrapulmonary veins than for arteries (202 vs 48% of KCl-induced contraction). In neonatal calves, histamine-induced contraction of veins also exceeded that of arteries (230 vs 54% of KCl-induced contraction); however, unlike in young adult cattle, histamine produced notable contraction of large and small bronchi (48 and 60% of methacholine-induced contraction, respectively). CONCLUSIONS AND CLINICAL RELEVANCE: Compared with intrapulmonary arteries, intrapulmonary veins have greater contractile responses to histamine in neonatal and young adult cattle. Data suggest loss of histamine responsiveness in bronchial smooth muscle as neonatal calves grow to young adults. Venodilation may be useful in treatment of lung edema in cattle. [less ▲]

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See detail« Comment servir le souverain ». A propos d’un traité pseudo-platonicien inédit
Bauden, Frédéric ULiege; Ghersetti, Antonella

in Quaderni di Studi Arabi (2003), 20-21

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See detailDetuning effects in the one-photon mazer
Bastin, Thierry ULiege; Martin, John ULiege

in Physical Review. A (2003), 67

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far ... [more ▼]

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far from being direct. Interesting effects of the mazer physics are pointed out. In particular, it is shown that the cavity may slow down or speed up the atoms according to the sign of the detuning and that the induced emission process may be completely blocked by use of a positive detuning. It is also shown that the detuning adds a potential step effect not present at resonance and that the use of positive detunings defines a well-controlled cooling mechanism. In the special case of a mesa cavity mode function, generalized expressions for the reflection and transmission coefficients have been obtained. The general properties of the induced emission probability are finally discussed in the hot, intermediate, and cold atom regimes. Comparison with the resonant case is given. [less ▲]

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See detailBinding and migration across fibronectin and VCAM-1 of cycling hematopoietic progenitor cells.
Gothot, André ULiege; Giet, Olivier ULiege; Huygen, Sandra et al

in Leukemia & Lymphoma (2003), 44(8), 1379-83

Using different experimental approaches, it has been established that transplantability of hematopoietic/stem progenitor cells is ineffective during transit through the cell cycle. Although primitive stem ... [more ▼]

Using different experimental approaches, it has been established that transplantability of hematopoietic/stem progenitor cells is ineffective during transit through the cell cycle. Although primitive stem cells are responsive to mitogenic stimulation in optimized ex vivo conditions, defective engraftment of generated cells may limit their detection in standard transplantation models as well as their use in clinical cell therapy. The activation level of adhesion receptors is modulated by stimulation of cytokine receptors via "inside-out" signaling. This prompted us to study the interactions of progenitor cells with fibronectin (Fn) in different phases of the cell cycle. We first demonstrated that adhesion to Fn was stimulated in S/G2 + M as compared to G0/G1, in ex vivo cultured CD34+ cells, with a predominant usage of very late antigen (VLA)-5 over that of VLA-4. We next determined that maximal Fn binding in active phases of the cell cycle limited cell motility toward stromal cell-conditioned medium. It was also observed that VLA-4 and VLA-5 ability to mediate adhesion or migration varied independently during cell cycle transit. Finally, in synchronized progenitor cells executing a first cell cycle ex vivo, a reversible increase in Fn binding was associated with a reversible decrease in adhesion to vascular cell-adhesion molecule (VCAM)-1. Overall, these observations suggest that defective engraftment of cycling stem/progenitor cells may result, at least in part, from abnormal trafficking related to changes in the activation level of adhesion receptors. [less ▲]

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See detailLe complexe Chrysoperla carnea en Belgique (Neuroptera : Chrysopidae)
Bozsik, Andras; Mignon, Jacques ULiege; Gaspar, Charles

in Notes Fauniques de Gembloux (2003), 50

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à ... [more ▼]

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à l’aide d’un filet représente le principal mode d’échantillonnage. Les individus capturés furent identifiés sur base des descriptions de Thierry et al. (1992), Duelli (1995, 1999 communication personnelle), ainsi que par comparaison, soit avec différents types morphologiques (de D. Thierry), soit à des individus identifiés sur base de leurs chants (par P. Duelli). Chrysoperla kolthoffi sensu Cloupeau (Ch.c.c.4. ou « motorboat » sensu Henry) constitue le taxon le plus représenté dans les différentes localités. Chrysoperla carnea sensu Cloupeau (« low motorboat » sensu Henry) est également souvent rencontrée abondamment, principalement en automne. Seule Chrysoperla lucasina Lacroix est observée plus rarement chaque année et dans chaque lieu. La fréquence saisonnière de Ch. carnea s.C. est variable. Ainsi, elle est relativement faible en été et elle augmente progressivement au cours de l’automne. A cette période, les proportions de Ch. kolthoffi diminuent tandis que le taux de Ch. lucasina reste stable. [less ▲]

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See detailBildegedende diagnostik des gehirns beim alternden hund
Van Bree, H.; Gielen, I.; Peremans, K. et al

in Der Prattische Tierazt (2003)

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See detailLipid And Oxylipin Profiles During Aging And Sprout Development In Potato Tubers (Solanum Tuberosum L.)
Fauconnier, Marie-Laure ULiege; Welti, R.; Blee, E. et al

in Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids (2003), 1633(2),

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See detailFin de législature: le point sur l'autonomie fiscale des communautés et des régions
Bourgeois, Marc ULiege

in Comptabilité et Fiscalité Pratiques (2003)

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See detailLa guerre et la médecine d'une culture de paix. 5- Synopsis des armes non-létales.
Pierard, Gérald ULiege

in FALCO (2003), Mars

Non lethal weapons may be harmful for people. The effects are accidental in some instances. For some weapons, they are clearly intentional. The eventuality of a fatal issue cannot be ruled out.

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See detailAbsolute and relative quantification : beyond mutually exclusive word classes.
Brems, Lieselotte ULiege; Davidse, Kristin

in Belgian Journal of English Language and Literatures. New Series (2003), 1

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See detailIn vitro stability and immunoreactivity of the native and recombinant plant food 2S albumins Ber e 1 and SFA-8
Murtagh, M.; Archer, D.; Dumoulin, Mireille ULiege et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2003), 8

Background The ability of an intact protein to reach the circulatory system may be a prerequisite to allergenicity and many allergens, particularly those from plant foods, have been found to be ... [more ▼]

Background The ability of an intact protein to reach the circulatory system may be a prerequisite to allergenicity and many allergens, particularly those from plant foods, have been found to be consistently more resistant to digestion by pepsin than other proteins. Objective This study assessed the pepsinolytic stability of native 2S albumins from Brazil nut and sunflower seed and their recombinant versions produced in Pichia pastoris. The physicochemical stability of native and recombinant Brazil nut 2S albumins and recombinant sunflower seed 2S albumin was also assessed. The immunoreactivity of native Brazil nut 2S albumin and recombinant 2S albumins was compared using serum from patients allergic to Brazil nuts and animals immunized with native 2S albumins. Methods Digestibility was measured in simulated gastric fluid followed by SDS-PAGE. Circular dichroism spectra were used to analyse unfolding, as proteins were denatured by temperature, pH and guanidinium chloride. Immunoreactivity was assessed by immunoblot, RAST and ELISA. Results Brazil nut 2S albumin was significantly more resistant to proteolytic digestion than other Brazil nut proteins. It was also resistant to thermally and chemically induced denaturation. Equally high resistance to proteolytic digestion was observed with sunflower seed 2S albumin. The recombinant albumins mirrored their native counterparts in stability and immunoreactivity. Conclusion The important food allergen Brazil nut 2S albumin is as stable to digestion as is sunflower seed 2S albumin, whose allergenicity has yet to be determined. The 2S albumins and their recombinant counterparts could not be easily denatured by physicochemical treatments. The results suggest that 2S albumin is the only Brazil nut protein to reach the gut immune system intact. The production of properly folded recombinant proteins will facilitate mechanistic studies as well as diagnostic testing and antigen-based therapies. [less ▲]

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See detailBiostratigraphic correlation at the Late or/and Latest Famennian from Western, Central and Eastern European sections. State of the art.
Streel, Maurice ULiege; Avkhimovitch, V.I.; Berkowski, B et al

in Newsletter. Subcommission on Devonian Stratigraphy (2003), 19

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See detailL'etude clinique du mois. L'etude ALLHAT-LLT.
Kulbertus, Henri ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2003), 58(1), 53-8

ALLHAT-LLT was part of the ALLHAT study. The purpose was to determine whether pravastatin compared with usual care reduces all-cause mortality in older, moderately hypercholesterolaemic, hypertensive ... [more ▼]

ALLHAT-LLT was part of the ALLHAT study. The purpose was to determine whether pravastatin compared with usual care reduces all-cause mortality in older, moderately hypercholesterolaemic, hypertensive patients with at least one additional coronary heart disease (CHD) risk factor. 10,355 ambulatory patients, aged 55 years or more, with LDL cholesterol of 120-189 mg/dl (or, 100-129 mg/dl if known CHD) and triglycerides < 350 mg/dl, were randomised to pravastatin (40 mg/d; n = 5,170), or usual care (n = 5,185). Mean age was 66 years; 49% were women; 38% were black and 23% hispanic; 14% had a history of CHD and 35%, type 2 diabetes. Baseline mean total cholesterol was 224 mg/dl; LDL-C, 146 mg/dl; HDL-C, 48 mg/dl, and triglycerides, 152 mg/dl. Mean follow-up was 4.8 years. Among usual care patients, 32% of those with known CHD and 29% of those without CHD started taking lipid-lowering drugs. At year 4, total cholesterol was reduced by 17.2% with pravastatin and by 7.6% with usual care. A random sample had their LDL-C levels assessed: there was a reduction of 28% with pravastatin and of 11% with usual care. All-cause mortality was similar in the two groups (RR, 0.99; 95% CI, 0.89-1.11; p = 0.88), with 6-year mortality rates of 14.9% (pravastatin) and 15.3% (usual care). CHD event-rates were not different between the two groups (RR, 0.91; 95% CI, 0.79-1.04; p = 0.16); 6-year CHD event rates were 9.3% (pravastatin) and 10.4% (usual care), respectively. These results are likely due to the small differential in total cholesterol (9.6%) and LDL-C (16.7%) between pravastatin and usual care, compared with prior statin trials. Such an unusual differential essentially results from the open table of the study and from the possibility of prescribing a statin in the usual care group. [less ▲]

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See detailAssessment of mechanobiological models for the numerical simulation of tissue differentiation around immediately loaded implants.
Geris, Liesbet ULiege; Van Oosterwyck, H.; Vander Sloten, J. et al

in Computer Methods in Biomechanics & Biomedical Engineering (2003), 6(5-6), 277-88

Nowadays, there is a growing consensus on the impact of mechanical loading on bone biology. A bone chamber provides a mechanically isolated in vivo environment in which the influence of different ... [more ▼]

Nowadays, there is a growing consensus on the impact of mechanical loading on bone biology. A bone chamber provides a mechanically isolated in vivo environment in which the influence of different parameters on the tissue response around loaded implants can be investigated. This also provides data to assess the feasibility of different mechanobiological models that mathematically describe the mechanoregulation of tissue differentiation. Before comparing numerical results to animal experimental results, it is necessary to investigate the influence of the different model parameters on the outcome of the simulations. A 2D finite element model of the tissue inside the bone chamber was created. The differentiation models developed by Prendergast, et al. ["Biophysical stimuli on cells during tissue differentiation at implant interfaces", Journal of Biomechanics, 30(6), (1997), 539-548], Huiskes et al. ["A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation", Journal of Material Science: Materials in Medicine, 8 (1997) 785-788] and by Claes and Heigele ["Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing", Journal of Biomechanics, 32(3), (1999) 255-266] were implemented and integrated in the finite element code. The fluid component in the first model has an important effect on the predicted differentiation patterns. It has a direct effect on the predicted degree of maturation of bone and a substantial indirect effect on the simulated deformations and hence the predicted phenotypes of the tissue in the chamber. Finally, the presence of fluid also causes time-dependent behavior. Both models lead to qualitative and quantitative differences in predicted differentiation patterns. Because of the different nature of the tissue phenotypes used to describe the differentiation processes, it is however hard to compare both models in terms of their validity. [less ▲]

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See detailPetrology of the Lyngdal granodiorite (southern Norway) and the role of fractional crystallization in the genesis of Proterozoic rapakivi-like granites
Bogaerts, Michel; Scaillet, Bruno; Liégeois, Jean-Paul ULiege et al

in Precambrian Research (2003), 124(2-4), 149-184

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See detailLa libre circulation des personnes dans l’Union européenne. Chronique de jurisprudence et de législation
Carlier, Jean-Yves ULiege

in Journal de Droit Européen [=JDE] (2003), 11(107), 79

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See detailProtocole GPG et succès de reproduction
Hanzen, Christian ULiege; Boudry, B.; Bouchard, E.

in Point Vétérinaire (2003), 34(238, AUG-SEP), 50-54

In cows, an average success rate of 32% for artificial insemination is obtained using the ovulation synchronisation GPG protocol in cows. This percentage is similar to that obtained in the same conditions ... [more ▼]

In cows, an average success rate of 32% for artificial insemination is obtained using the ovulation synchronisation GPG protocol in cows. This percentage is similar to that obtained in the same conditions after insemination of observed heat (32.6%) and slightly better to that obtained after synchronisation of heat using one or two doses of PgF(2alpha) (26,9 and 28.8%). The protocol has a positive effect on fertility expressed as the percentage of gravid cows four months after calving. The protocol may cause early return to oestrus, either after the first injection of GnRH or after the PgF(2alpha) injection. In heifers, the protocol induces a shortening of the cycle, which suggests that further research is needed on the interval between injections. The protocol does not result in a higher percentage of multiple ovulation. Embryonic mortality is about 7%. [less ▲]

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See detailFlow cytometric cerebrospinal fluid analysis in children
Häusler, M.; Sellhaus, B.; Schweizer, K. et al

in Pathology Research and Practice (2003), 199(10), 667-675

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume ... [more ▼]

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume, surface antigen expression) even in small amounts of cells. Data on CSF FC in children are very limited. Here, we summarize our 3-year experience of CSF FC routinely performed in pediatric patients with assumed inflammatory central nervous system (CNS) disease. Among 109 samples sent for analysis, flow cytometric detection of major leukocyte subsets was possible in 78% (85 out of 109), which exceeds the 31% rate of our retrospective microscopic pediatric control group. Apart from physiologic lymphocytes (100%) or monocytes (48%), 11 out of these 85 samples showed granulocytes, two showed proliferated monocytes, and nine displayed proliferated lymphocytes. In most children, the proliferated lymphocytes consisted of a polyclonal population of CD4+ and CD8+ T cells. Compared with literature data, eight children showed abnormally composed lymphocyte subsets (surface antigen expression) within the main lymphocyte population. However, none of these changes was specific for distinct diseases or allowed a distinction between patients with and without primary inflammatory processes. These data suggest that CSF FC may be the most effective modality to differentiate major CSF leukocyte subsets. At present, further differentiation of distinct cell populations, such as proliferated lymphocytes, is of limited clinical impact. This may, however, gain increasing interest in the future. [less ▲]

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See detailStructural integral monitoring by vibration measurements
Yan, Ai-Min; De Boe, Pascal; Golinval, Jean-Claude ULiege

in FM2003 - Structural Integrity and Materials Aging (2003)

This paper presents a comparative study on several approaches of structural damage diagnosis based on vibration measurements. Stochastic subspace identification method is used to identify modal parameters ... [more ▼]

This paper presents a comparative study on several approaches of structural damage diagnosis based on vibration measurements. Stochastic subspace identification method is used to identify modal parameters and to generate a Kalman prediction model, which are taken as damage-sensitive features for structural damage detection. A statistical process control technique based on principal component analysis (PCA) is also presented. An improvement and enhancement of PCA are proposed. It is assumed that without damage, structural responses should remain approximately in a hyperplane defined by the principal directions of data. Damage localization is explored with these methods. As only the measured output signals are needed, the methods are convenient for an on-line monitoring. The efficiency and limitation of the proposed methods are illustrated by a practical application. [less ▲]

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See detailRedefining the role of psr in beta-lactam resistance and cell autolysis of Enterococcus hirae.
Sapunaric, Frédéric ULiege; Franssen, Christine; Stefanic, Patrick et al

in Journal of Bacteriology (2003), 185(20), 5925-35

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain ... [more ▼]

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain R40 of Enterococcus hirae was investigated by disruption or substitution of the corresponding pbp5 and psr genes by Campbell-type recombination. The resulting modifications were confirmed by hybridization and PCR. The low susceptibility of E. hirae to beta-lactams was confirmed to be largely dependent on the presence of PBP5. However, against all expectations, inactivation of psr in ATCC 9790 or complementation of R40 cells with psr did not modify the susceptibility to benzylpenicillin or the growth and cell autolysis rates. These results indicated that the psr gene does not seem to be involved in the regulation of PBP5 synthesis and consequently in beta-lactam resistance or in the regulation of cell autolysis in E. hirae. [less ▲]

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See detailLa sentence arbitrale
Caprasse, Olivier ULiege

in Actualités du Droit (2003), 3

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See detailFirst-principles calculation of the band offset at BaO/BaTiO3 and SrO/SrTiO3 interfaces
Junquera, J.; Zimmer, M.; Ordejon, P. et al

in Physical Review. B, Condensed Matter and Materials Physics (2003), 67

We report first-principles density-functional pseudopotential calculations on the atomic structures, electronic properties, and band offsets of BaO/BaTiO3 and SrO/SrTiO3 nanosized heterojunctions grown on ... [more ▼]

We report first-principles density-functional pseudopotential calculations on the atomic structures, electronic properties, and band offsets of BaO/BaTiO3 and SrO/SrTiO3 nanosized heterojunctions grown on top of a silicon substrate. The density of states at the junction does not reveal any electronic induced interface states. A dominant perovskite character is found at the interface layer. The tunability of the band offset with the strain conditions imposed by the substrate is studied. Using previously reported theoretical data available for Si/SrO, Si/BaO, SrTiO3/Pt, and BaTiO3/SrRuO3 interfaces we extrapolate the band alignments along two gate stacks of technological interest: Si/SrO/SrTiO3/Pt and Si/BaO/BaTiO3/SrRuO3 heterostructures. [less ▲]

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See detailModel Updating Based on Frequency Response Functions Using A General Finite Element Code
Yan, Ai-Min; Golinval, Jean-Claude ULiege

in European Journal of Mechanical and Environmental Engineering (2003), 48(3), 149-162

Model updating techniques using frequency response function (FRF) data are studied in this paper. The numerical techniques are discussed for implementation with a large commercial finite element (FE ... [more ▼]

Model updating techniques using frequency response function (FRF) data are studied in this paper. The numerical techniques are discussed for implementation with a large commercial finite element (FE ) code. System equivalent reduction expansion process is adopted to reduce the complete FE solutions onto the experimental degrees of freedom. The rank-deficiency difficulty with this method is overcome using either of two numerical techniques: diagonal perturbation and singular value decomposition. This second technique is also used in solving the updating equation. Experimental FRF data are compared with the FE solutions, and the updated model parameters are obtained via an iteration procedure. A simplified frequency domain assurance criterion is proposed to evaluate the correlation between the FE model and the measured structure at the chosen frequencies. After verifying the efficiency of the methods with several benchmark tests, the program is applied to an aeroplane model test. Some conclusions are given and remaining problems illustrated. [less ▲]

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See detailL’idole brisée : la droite belge francophone et la crise morale de la France (1934-1938)
Lanneau, Catherine ULiege

in Journal of Belgian History = Revue Belge d'Histoire Contemporaine = Belgisch Tijdschrift voor Nieuwste Geschiedenis (2003), XXXIII(1-2), 177-214

The French-speaking right wing in Belgium has always granted a paramount place to France in its ideological cosmography. The concept of everlasting France, of her “mission”, of the part she could play on ... [more ▼]

The French-speaking right wing in Belgium has always granted a paramount place to France in its ideological cosmography. The concept of everlasting France, of her “mission”, of the part she could play on the international scene are topics wondered about constantly in intellectual and middle-class circles. The thirties and mostly the Popular Front era provide the Conservatives with a splendid opportunity to describe the future of their cultural icon with awe: the more the international context is threatening, the more France seems to have become fragile, isolated and going down the slope. Using the news given by the national papers or the widely circulated Parisian press, right-wing Belgians brood, of course, about the eclipse of France’s might, but point chiefly to the moral crisis as its cause. Very often they feel some nostalgia for the “Ancien Régime” and see the origin of the worrying current phenomenon in the hated French Revolution. Lot of factors are intertwined in the definition of the moral decay, but some are particularly highlighted. France is accused to be invaded by foreigners (their Jewish origins and Marxist creeds being stressed); Free-Masonry has a bad influence, as well as laic teaching, perverting youth by its pacifist and internationalist leanings. The degeneration of the religious spirit is lamented on account of its influence on the birth rate: the “Elder Daughter of the Church” gets emptier and emptier, whereas the populations of Fascist Italy and Nazi Germany are blooming. Opposition to parliamentary system is to the fore, as the politico-financial scandals, the governmental instability, the disreputable ways of the politicians themselves contribute all to the idea of the moral crisis. A cultural decline is parallel, with a loss of spirituality in the French society, engulfed in materialism and coarseness. Their stinging attacks, their bombastic style show how deeply rooted is the “decay of France” thesis among Belgian Conservatives. Beyond the French case, they fear a possible contamination of Belgium and the disappearance of their own traditional but vanishing values. Their fears and frights have certainly played a part in the 1936 turn-around towards the so-called Belgian “politique d’indépendance” in foreign affairs. [less ▲]

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See detailInteret des expectorations induites dans l'exploration de l'asthme.
Louis, Renaud ULiege; Bettiol, Jane; Cataldo, Didier ULiege et al

in Revue des Maladies Respiratoires (2003), 20(2 Pt 1), 215-23

INTRODUCTION: The technique of induced expectoration generates sputum by the inhalation of hypertonic saline. On account of its non-invasive character, its simplicity, its relative harmlessness, its cost ... [more ▼]

INTRODUCTION: The technique of induced expectoration generates sputum by the inhalation of hypertonic saline. On account of its non-invasive character, its simplicity, its relative harmlessness, its cost effectiveness and its reproducibility this technique, that appeared in the early 1990's, has rapidly established itself as the technique of choice in the investigation of bronchial inflammation in asthma. STATE OF THE ART: We present the results of our studies that have contributed to the validation of the technique at the methodological level and to the exploitation of the cellular contents as much as the fluid phase of the expectorations in characterising bronchial inflammation in asthmatics. Our results confirm an infiltration of the airways of asthmatics with eosinophils that appears to be proportional to the severity of the illness. We evaluate the effect of inhaled steroids and of theophylline on sputum eosinophilia and bronchial reactivity and discuss the role of eosinophils on bronchial hyperreactivity. Finally we discuss the use of induced expectoration in clinical practice in asthma. PERSPECTIVES: The analysis of induced sputum could well become a valuable tool in the clinical evaluation and monitoring of asthma in the same way as symptoms and abnormalities of lung function. CONCLUSIONS: Induced expectoration has certainly contributed to the understanding of the cellular and molecular mechanisms of asthma as well as the role of bronchial inflammation in the clinical manifestations of the disease. [less ▲]

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See detailModeling tracer injection and well-aquifer interactions: A new mathematical and numerical approach
Brouyère, Serge ULiege

in Water Resources Research (2003), 39(3),

[1] A new mathematical and numerical approach is presented to model solute exchange between a well and the surrounding aquifer for the interpretation of field tracer tests. On the basis of water and ... [more ▼]

[1] A new mathematical and numerical approach is presented to model solute exchange between a well and the surrounding aquifer for the interpretation of field tracer tests. On the basis of water and tracer mass balance equations integrated over the volume of water in the well, the approach allows for finite volumes of tracer fluid and water flush. It deals with tracer mixing and capturing in the well bore, local distortion of the flow field around the well, and possible tracer back-migration into the well. A numerical solution, implemented in the three-dimensional finite element groundwater flow and transport simulator SUFT3D, is proposed that allows for modeling nonuniform distributions of tracer mass fluxes along the well screens related to variations in aquifer hydraulic conductivity. Showing its ability to reproduce concentration evolutions monitored in a well during field tracer experiments, considering various injection conditions, validates the approach. [less ▲]

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See detailIncidental control of rosacea by somatostatin.
Pierard, Claudine ULiege; Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(3), 249-51

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings ... [more ▼]

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings about the possible modulatory role of somatostatin in the outcome of rosacea. METHOD: Four patients presenting long-standing recalcitrant facial rosacea were treated with octreotide for diabetic retinopathy. RESULTS: Rosacea improved rapidly and even cleared without any recurrence in 3 of the patients. CONCLUSION: The beneficial effect might be attributed to inhibitory actions on the sebaceous gland, the neovascularization and/or on the inflammatory process. [less ▲]

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See detailA propos de la prescription des mensualités d'un crédit
Biquet, Christine ULiege

in Annuaire juridique du crédit et du règlement collectif de dettes (2003)

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See detailMultiple mechanisms control brain aromatase activity at the genomic and non-genomic level
Balthazart, Jacques ULiege; Baillien, Michelle; Charlier, Thierry ULiege et al

in Journal of Steroid Biochemistry & Molecular Biology (2003), 86

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms ... [more ▼]

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms. We review here these two types of control mechanisms and their potential contribution to various aspects of brain physiology in quail. High levels of aromatase mRNA, protein and activity (AA) are present in the preoptic area of this species where the transcription of aromatase is controlled mainly by steroids. Estrogens acting in synergy with androgens play a key role in this control and both androgen and estrogen receptors (ER; alpha and beta subtypes) are present in the preoptic area even if they are not necessarily co-localized in the same cells as aromatase. Steroids have more pronounced effects on aromatase transcription in males than in females and this sex difference could be caused, in part, by a sexually differentiated expression of the steroid receptor coactivator 1 in this area. The changes in aromatase concentration presumably control seasonal variations as well as sex differences in brain estrogen production. Aromatase activity in hypothalamic homogenates is also rapidly (within minutes) down-regulated by exposure to conditions that enhance protein phosphorylation such as the presence of high concentrations of calcium, magnesium and ATP. Similarly, pharmacological manipulations such as treatment with thapsigargin or stimulation of various neurotransmitter receptors (alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid (AMPA), kainate, and N-methyl-d-aspartate (NMDA)) leading to enhanced intracellular calcium concentrations depress within minutes the aromatase activity measured in quail preoptic explants. The effects of receptor stimulation are presumably direct: electrophysiological data confirm the presence of these receptors in the membrane of aromatase-expressing cells. Inhibitors of protein kinases interfere with these processes andWestern blotting experiments on brain aromatase purified by immunoprecipitation confirm that the phosphorylations regulating aromatase activity directly affect the enzyme rather than another regulatory protein. Accordingly, several phosphorylation consensus sites are present on the deduced amino acid sequence of the recently cloned quail aromatase. Fast changes in the local availability of estrogens in the brain can thus be caused by aromatase phosphorylation so that estrogen could rapidly regulate neuronal physiology and behavior. The rapid as well as slower processes of local estrogen production in the brain thus match well with the genomic and non-genomic actions of steroids in the brain. These two processes potentially provide sufficient temporal variation in the bio-availability of estrogens to support the entire range of established effects for this steroid. [less ▲]

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See detailCompte rendu de Seuphor. N° spécial d’Archipel, Cahier international de littérature
Robert, Laurent ULiege

in Textyles : Revue des Lettres Belges de Langue Française (2003), 23

Compte rendu d'un ouvrage contenant des documents du poète Michel Seuphor et apportant quelques précisions d'ordre biographique sur cet auteur

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See detailLa peau de l'acromégale.
Hermanns-Lê, Trinh ULiege; QUATRESOOZ, Pascale ULiege; Arrese Estrada, Jorge ULiege et al

in Dermatologie Actualité (2003), 75

L'acromégalie est l'expression clinique d'une hypersécrétion chronique de l'hormone de croissance dont la source est, dans la plupart des cas, un adénome hypophysaire. Son diagnostic est souvent posé ... [more ▼]

L'acromégalie est l'expression clinique d'une hypersécrétion chronique de l'hormone de croissance dont la source est, dans la plupart des cas, un adénome hypophysaire. Son diagnostic est souvent posé tardivement, car les signes cliniques se développent de façon insidieuse. [less ▲]

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See detailNegative association between smoking and anti-saccharomyces cerevisiae antibodies in Crohn's disease
Van Kemseke, Catherine ULiege; Belaiche, Jacques ULiege; Steeman, C. et al

in Acta Gastro-Enterologica Belgica (2003), 66(1, Jan-Mar), 1-6

Background: Crohn's disease (CD) is a polygenic multifactorial heterogeneous disease. Anti-Saccharomyces Cerevisiae antibodies (ASCA) correlate highly with CD and are present in 50-80% of patients. The ... [more ▼]

Background: Crohn's disease (CD) is a polygenic multifactorial heterogeneous disease. Anti-Saccharomyces Cerevisiae antibodies (ASCA) correlate highly with CD and are present in 50-80% of patients. The reason for ASCA positivity or negativity in CD is unknown. The aim of our work was to analyse clinical, epidemiological and genetic characteristics in ASCA + or ASCA- CD patients. Methods : 113 patients with CD were tested for ASCA (IgA and IgG) by using a commercial kit (Medipan Diagnostica). Age, gender, systemic manifestations, familial form of disease, age at diagnosis, location and behaviour of the disease, smoking habit as well as genotyping for -308 TNF gene polymorphisms were determined. Results : 38.9% CD patients were negative for both IgA and IgG ASCA while 61.1% were ASCA positive (respectively IgA and IgG : 31.9%; IgA only : 9.7%; IgG only : 19.5%). The only significant difference between ASCA+ and ASCA- patients was for smoking habit : there were 29% smokers in ASCA+ versus 50% in ASCA- CD patients (P = 0.03). This low proportion of smokers was more prominent in ASCA IgA+ patients than in isolated ASCA IgG+ patients (25.6% versus 45.5%) and was minimal in patients with high titers of ASCA IgA (0/8). Logistic regression showed smoking habit still borderline for significance (P = 0.057). Conclusions : Our results suggest a negative association between smoking and ASCA positivity in CD. This association was more prominent for ASCA IgA+. It indicates that smoking habit should be taken into account when analysing ASCA status in CD patients and may suggest an influence of smoking on immunization against intestinal material. [less ▲]

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See detailToward a better control of internal structure and external morphology of mesoporous silicas synthesized using a nonionic surfactant
Léonard, Alexandre ULiege; Blin, J. L.; Robert, M. et al

in Langmuir (2003), 19(13), 5484-5490

Mesoporous silicas with controlled morphologies have been synthesized using decaoxyethylene cetyl ether [C 16(EO) 10] as a surfactant (10 wt % in aqueous solution). A large series of characterization ... [more ▼]

Mesoporous silicas with controlled morphologies have been synthesized using decaoxyethylene cetyl ether [C 16(EO) 10] as a surfactant (10 wt % in aqueous solution). A large series of characterization results (SEM, TEM, XRD, and nitrogen adsorption-desorption analysis) have demonstrated how the surfactant/silica molar ratio as well as hydrothermal treatment conditions can drastically influence not only the regular organization of the compounds on the nanometer scale but also the morphogenesis of the particles at the micrometer level. High loadings of a silica precursor yield highly structured mesoporous compounds with a morphology of ropes, gyroids and toroids whereas an increase of the surfactant/silica molar ratio results in spherical materials with a disordered channel array. A phase transition from hexagonal to disordered structure and then again to a regular hexagonal array with increasing gel heating temperature from 40 to 80°C has been evidenced. [less ▲]

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See detailAn Improved Method of Photometric Mode Identification: Applications to Slowly Pulsating B, beta Cephei, delta Scuti and gamma Doradus Stars
Dupret, Marc-Antoine ULiege; Scuflaire, Richard ULiege; Noels-Grötsch, Arlette ULiege et al

in Astrophysics & Space Science (2003), 284

We present an improved version of the method of photometric mode identification based upon the inclusion of non-adiabatic eigenfunctions determined in the stellar atmosphere, according to the formalism ... [more ▼]

We present an improved version of the method of photometric mode identification based upon the inclusion of non-adiabatic eigenfunctions determined in the stellar atmosphere, according to the formalism recently proposed by Dupret et al. (2002). We apply our method to beta Cephei, Slowly Pulsating B, delta Scuti and gamma Doradus stars. Besides identifying the degree l of the pulsating stars, our method is also a tool for improving the knowledge of stellar interiors and atmospheres, by imposing constraints on the metallicity for beta Cephei and SPBs, the characteristics of the superficial convection zone for delta Scuti and gamma Doradus stars and the limb-darkening law. [less ▲]

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See detailEvaluation of false transrectal ultrasonographic pregnancy diagnoses in sheep by measuring the plasma level of pregnancy-associated glycoproteins
Karen, A.; Beckers, Jean-François ULiege; Sulon, Joseph ULiege et al

in Reproduction Nutrition Development (2003), 43(6, NOV-DEC), 577-586

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy ... [more ▼]

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy-associated glycoproteins (ovPAG). A total of 424 Awassi x Merino ewes were synchronized for estrus and examined by transrectal ultrasonography. In Experiment 1, the ewes (n = 156) were repeatedly scanned in a standing position on d 29, 36 and 50 of gestation. Similarly, the ewes (n = 268) in Experiment 2 were scanned on d 24, 29 and 34 of gestation, but these ewes were fasted for 12 h prior to the examination and the abdominal wall of each animal was lifted up by the hands of the assistant during the scanning. Blood samples were withdrawn after each transrectal ultrasonographic examination in both experiments. Ovine PAG concentrations were measured in plasma by a heterologous radioimmunoassay and the cut-off value for pregnancy was greater than or equal to 1 ng.mL(-1). Based on the lambing performance, in Experiment 1, altogether 47 false negative and 38 false positive diagnoses were made by transrectal ultrasonography in 24 and 33 ewes, respectively between d 29 and 50 of gestation. In Experiment 2, altogether 8 false negative and 13 false positive diagnoses both were made in 7 ewes between d 24 and 34 of gestation. In both experiments, all ewes with false negative diagnoses had ovPAG concentrations higher than the threshold level for pregnancy diagnosis and all ewes with false positive diagnoses had ovPAG concentrations lower than the threshold of pregnancy. Furthermore, by the PAG-RIA test all lambed or aborted ewes (n = 63) were correctly diagnosed as pregnant and with three exceptions, all non-lambed ewes (n = 361) were correctly diagnosed as non-pregnant during the examined periods of both experiments. [less ▲]

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See detailA arbitragem e os grupos de sociedades
Caprasse, Olivier ULiege

in Revista de Direito Bancario, do Mercado de Capitais e da Arbitragem (2003)

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See detailAlong or across front ocean survey strategy? The estimation of quasi-geostrophic vertical velocities and temperature fluxes
Rixen, Michel; Allen, J. T.; Pollard, R. T. et al

in Geophysical Research Letters (2003), 30(5), 61-68

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio ... [more ▼]

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio-chemical properties when the front is sufficiently developed. The cruise design based on the optimal reconstruction of the density fields does however not imply that derived variables like quasi-geostrophic (QG) vertical velocities and temperature fluxes also exhibit minimal associated errors. Here we present results of optimized sampling strategies for diagnostic QG vertical velocities (wQG) and temperature fluxes (θQG) derived from the omega equation. Results are illustrated in the same framework, for the Iceland-Faroes oceanic frontal area and for a control model and reveal that at these spatio-temporal scales, the unusual AL may also provide better estimations of vertical velocities and temperature fluxes compared to the classic AC, especially when the front is sufficiently developed. [less ▲]

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See detailDifference in risk factors for postoperative nausea and vomiting.
Stadler, Michaela; Bardiau, Françoise ULiege; Seidel, Laurence ULiege et al

in Anesthesiology (2003), 98(1), 46-52

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for ... [more ▼]

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for postoperative nausea and vomiting in various surgical populations in a clinical audit setting. METHODS: The study included 671 consecutive surgical inpatients, aged 15 yr or more, undergoing various procedures. The study focused on postoperative nausea visual analog scale scores every 4 h and vomiting episodes within 72 h. Both vomiting and retching were considered as emetic events. Patient-, anesthesia-, and surgery-related variables that were considered to have a possible effect on the proportion of patients experiencing postoperative nausea and/or vomiting were examined. The bivariate Dale model for binary correlated outcomes was used to identify selectively the potential risk factors of postoperative nausea and vomiting. RESULTS: Among the 671 patients in the study, 126 (19%) reported one or more episodes of nausea, and 66 patients (10%) suffered one or more emetic episodes during the studied period. There was a highly significant association between the two outcomes. Some risk factors were predictive of both nausea and vomiting (female gender, nonsmoking status, and general anesthesia). History of migraine and type of surgery were mainly responsible for nausea but not for vomiting. The predictive effect of risk factors was controlled for postoperative pain and analgesic drugs. CONCLUSION: This study shows that differences exist in risk factors of postoperative nausea and vomiting. These could be explained by differences in the physiopathology of the two symptoms. [less ▲]

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See detailLe passé récent, la réforme de l'impôt des personnes physiques, le cas des villes
Jurion, Bernard ULiege

in Bulletin de Documentation du Ministère des Finances (2003)

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See detailGene flow among wild Phaseolus lunatus L. populations in the Central Valley of Costa Rica
Ouedraogo, M.; Maquet, A.; Baudoin, Jean-Pierre ULiege

in Annual Report Bean Improvement Cooperative (2003), 46

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See detailEu10Mn6Sb13: A new ternary rare-earth transition-metal
Holm, A. P.; Park, S. M.; Condron, C. L. et al

in Inorganic Chemistry (2003), 42(15), 4660-4667

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 ... [more ▼]

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 crystallizes in the monoclinic space group C2/m with a = 15.1791(6) Angstrom, b = 19.1919(7) Angstrom, c = 12.2679(4) Angstrom, beta = 108.078(1)degrees, Z = 4 (R1 = 0.0410, wR2 = 0.0920), and T = 90(2) K. The structure of Eu10Mn6Sb13 is composed of double layers of Mn-centered tetrahedra separated by Eu2+ cations. The double layers are composed of edge- and corner-sharing Mn-centered tetrahedra which form cavities occupied by Eu2+ cations and [Sb-2](4-) dumbbells. Linear [Sb-3](5-) trimers bridging two tetrahedra across the cavity are also present. Bulk susceptibility data indicate paramagnetic behavior with a ferromagnetic component present below 60 K. Temperature-dependent electrical resistivity measurements show semiconducting behavior above 60 K (E-a = 0.115(2) eV), a large and unusually sharp maximum in the resistivity at similar to40 K, and metallic behavior below 40 K. Eu-151 Mossbauer spectra confirm that the europium is divalent with an average isomer shift of -11.2(1) mm/s at 100 K; the spectra obtained below 40 K reveal magnetic ordering of six of the seven europium sublattices and, at 4.2 K, complete ordering of the seven europium sublattices. [less ▲]

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See detailSkin weathering: the face at the interface.
Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 207(3), 248-50

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See detailScepticisme et science nouvelle dans les Dialogues faits à l'imitation des Anciens
Torero-Ibad, Alexandra ULiege

in Corpus, revue de philosophie (2003), 43

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See detailDavid A. Jackson: Theodor Storm. Dichter und demokratischer Humanist, Berlin 2001.
Gerrekens, Louis ULiege

in Schriften der Theodor-Storm-Gesellschaft (2003), 52

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See detailPregnancy-associated glycoprotein concentrations during pregnancy and the postpartum period in Azawak Zebu cattle
Melo de Sousa, Noelita ULiege; Zongo, M.; Pitala, W. et al

in Theriogenology (2003), 59(5-6), 1131-1142

Specific RIA systems were developed and used to measure pregnancy-associated glycoprotein (PAG) concentrations during gestation and the postpartum period in Azawak Zebu cows. Twelve females were palpated ... [more ▼]

Specific RIA systems were developed and used to measure pregnancy-associated glycoprotein (PAG) concentrations during gestation and the postpartum period in Azawak Zebu cows. Twelve females were palpated per rectum and diagnosed as pregnant. Blood samples were taken at 5-10-day intervals from approximately Week 8 of gestation until Week 10 postpartum (pp). One Zebu cow (Z15) initially diagnosed as pregnant showed PAG concentrations lower than the assay sensitivity (<0.20 ng/ml) and did not calve. Another cow (ZSand) showed abnormally high PAG concentrations during gestation and was excluded from the general PAG profile. The 10 other Zebu cows exhibited a very similar PAG profile. In these animals, concentrations increased progressively from Week 8 to 35 of gestation (from 6.0 +/- 4.2 to 196.0 +/- 34.8 ng/ml), remaining relatively constant until Week 39 (210.8 +/- 74.8 ng/ml), when they increased sharply to reach their highest level (1095.6 +/- 607.2 ng/ml) at around parturition. After delivery, PAG concentrations declined significantly (P < 0.05) until Week 2 postpartum (348.4 +/- 85.6 ng/ml) and slowly until Week 10 postpartum. Our results revealed that the PAG pattern in Zebu cattle was similar to those of taurine breeds during the first two trimesters of pregnancy, but differed in the peripartum period. [less ▲]

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See detailGraulichite-(Ce), a new arsenate mineral from the Stavelot Massif, Belgium
Hatert, Frédéric ULiege; Pasero, Marco; Fransolet, André-Mathieu ULiege et al

in European Journal of Mineralogy (2003), 15(4, JUL-AUG), 733-739

Graulichite-(Ce), ideally CeFe33+(AsO4)(2)(OH)(6), is a new mineral species from Hourt, Stavelot Massif, Belgium. It occurs in the most altered parts of a Devillian quartzite (Lower to Middle Cambrian ... [more ▼]

Graulichite-(Ce), ideally CeFe33+(AsO4)(2)(OH)(6), is a new mineral species from Hourt, Stavelot Massif, Belgium. It occurs in the most altered parts of a Devillian quartzite (Lower to Middle Cambrian), in close association with arsenopyrite, scorodite, mimetite, pharmacosiderite, and goethite. Graulichite-(Ce) forms 80 to 150 mum spherical aggregates of rhombohedral crystals, 50 to 80 mum length, which show the forms {10 (1) over bar2} and {10 (11) over bar}. The mineral is transparent and exhibits a light-green to brownish colour, with a resinous lustre. It is non-fluorescent and shows an irregular fracture, without any perceptible cleavage. The calculated density is 4.42 g/cm(3). Graulichite-(Ce) is uniaxial negative, with a mean refractive index close to 1.97(1) (lambda=590 nm), pleochroic from light green to yellowish. Electron microprobe analyses gave As2O5 31.20, P2O5 0.03, SO3 0.06, SiO2 0.03, Al2O3 3.09, Fe2O3 30.65, SrO 0.24, PbO 0.07, BaO 3.95, CaO 0.03, La2O3 2.26, Ce2O3 15.73, Nd2O3 2.08, H2O (calc.) 8.37, total 97.79 wt. %. The resulting empirical formula, calculated on the basis of 6 cations, is (Ce0.67Ba0.18La0.10Nd0.09Sr0.02)(Sigma1.06) (Fe2.683+Al0.42)(Sigma3.10)[(As(1.89)S(.001)square(0.10))(Sigma2.00)O-8][(OH)(5.57)(H2O)(0.43)](Sigma6.00). The single-crystal unit-cell parameters are a=7.288(2) and c=16.812(9) Angstrom, space group R (3) over barm. The seven strongest lines in the X-ray powder-diffraction pattern [d(in Angstrom)(I)(hkil)] are: 3.052(100)(11 (2) over bar3), 3.636(40)(11 (2) over bar0), 2.239(35)(10 (1) over bar7), 1.817(35)(22 (4) over bar0), 2.792(30)(0006), 5.906(25)(10 (1) over bar1), 1.968(25)(30 (3) over bar3). Graulichite-(Ce) is the iron analogue of arsenoflorencite-(Ce), and belongs to the crandallite mineral group, with the alunite-type structure. The crystal structure of graulichite-(Ce) has been refined, based on single-crystal X-ray diffraction data, to R=0.048. [less ▲]

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See detailMediolatinitas : légendes hagiographiques et statistique linguistique
Philippart de Foy, Caroline ULiege

in Hagiographica : Rivista di Agiografia e Biografia della Società Internazionale per lo Studio del Medioevo Latino (2003), X

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See detailUn monde de rejetés
Dumortier, Jean-Louis ULiege

in Traces (2003), 14

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See detailRelevance of bone mineral density, bone quality and falls in reduction of vertebral and non-vertebral fractures.
Hanssens, L.; Reginster, Jean-Yves ULiege

in Journal of musculoskeletal & neuronal interactions (2003), 3(3), 189-93

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the ... [more ▼]

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the community within the next fifteen years. However, the most effective way of setting up such preventive strategies is not yet unequivocally defined. Low bone mass and microarchitectural damage of bone tissue may account for a large part of the epidemiology of vertebral fractures. Extraskeletal determinants, including low muscle strength, poor balance and gait, all resulting in an increased propensity to fall, also play a major role in the occurrence of hip fracture. Depending on the localization of the fractures, the relative importance of skeletal and extraskeletal risk factors can significantly differ. For prevention of vertebral fractures, drugs affecting bone mass and skeletal architecture may provide a substantial benefit while hip fracture prevention will be more successfully targeted by multi-faceted strategies concentrating not only on the skeletal dimension of the fracture but also aiming, either pharmacologically or through multi-intervention programs, at a reduction in the incidence and in the consequences of falls in the elderly. [less ▲]

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See detailCytokinin levels in leaves, leaf exudate and shoot apical meristem of Arabidopsis thaliana during floral transition
Corbesier, Laurent; Prinsen, Els; Jacqmard, Annie ULiege et al

in Journal of Experimental Botany (2003), 54(392), 2511-2517

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis ... [more ▼]

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis thaliana has been successfully used to unravel signalling pathways by genetic and molecular approaches, but analyses are still required to determine the physiological signals involved in the control of floral transition. In this work, the putative role of cytokinins was investigated using vegetative plants of Arabidopsis (Columbia) induced to flower synchronously by a single 22 h long day. Cytokinins were analysed in leaf extracts, leaf phloem exudate and in the shoot apical meristem at different times during floral transition. It was found that, in both the leaf tissues and leaf exudate, isopentenyladenine forms of cytokinins increased from 16 h after the start of the long day. At 30 h, the shoot apical meristem of induced plants contained more isopentenyladenine and zeatin than vegetative controls. These cytokinin increases correlate well with the early events of floral transition. [less ▲]

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See detail"Reprise" et "Charbons ardents" - la mémoire et la lutte
Servais, Christine ULiege

in Cinémaction (2003), 110

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See detailL'application dans le temps de la peine de travail
Jacobs, Ann ULiege

in Revue de Droit Pénal et de Criminologie (2003)

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See detailPrimary intraventricular brain abscess.
Lambo, A.; NCHIMI LONGANG, Alain ULiege; Khamis, J. et al

in Neuroradiology (2003), 45(12), 908-10

We report a primary intraventricular brain abscess in a 13-year-old boy. We discuss possible explanations for this rare occurrence.

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See detailThe core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin encoded by bovine herpesvirus 4 was acquired from an ancestor of the African buffalo
Markine-Goriaynoff, N.; Georgin, J. P.; Goltz, M. et al

in Journal of Virology (2003), 77(3), 1784-1792

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only viral gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M). To ... [more ▼]

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only viral gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M). To investigate the origin and evolution of the Bo17 gene, we analyzed its distribution among BoHV-4 strains and determined the sequences of Bo17 from nine representative strains and of the C2GnT-M gene from six species of ruminants expected to encompass the group within which the gene acquisition occurred. Of 34 strains of BoHV-4, isolated from four different continents, all were found to contain the Bo17 gene. Phylogenetic analyses indicated that Bo17 was acquired from a recent ancestor of the African buffalo, implying that cattle subsequently acquired BoHV-4 by cross-species transmission. The rate of synonymous nucleotide substitution in Bo17 was estimated at 5 x 10(-8) to 6 x 10(-8) substitutions/site/year, consistent with previous estimates made under the assumption that herpesviruses have cospeciated with their hosts. The Bo17 gene acquisition was dated to around 1.5 million years ago. Bo17 sequences from BoHV-4 strains from African buffalo and from cattle formed two separate clades, estimated to have split about 700,000 years ago. Analysis of the ratio of nonsynonymous to synonymous nucleotide substitutions revealed a burst of amino acid replacements subsequent to the transfer of the cellular gene to the viral genome, followed by a return to a strong constraint on nonsynonymous changes during the divergence of contemporary BoHV-4 strains. The Bo17 gene represents the most recent of the known herpesvirus gene acquisitions and provides the best opportunity for learning more about this important process of viral evolution. [less ▲]

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See detailEinstein oscillators in thallium filled antimony skutterudites
Hermann, Raphaël ULiege; Jin, R. J.; Schweika, W. et al

in Physical Review Letters (2003), 90(13),

Inelastic neutron scattering measurements on several Tl filled skutterudites (Tl0.5Co3.5Fe0.5Sb12, Tl0.8Co3FeSb12, and Tl0.8Co4Sb11Sn) all show a sharp peak in the vibrational density of states at 57 ... [more ▼]

Inelastic neutron scattering measurements on several Tl filled skutterudites (Tl0.5Co3.5Fe0.5Sb12, Tl0.8Co3FeSb12, and Tl0.8Co4Sb11Sn) all show a sharp peak in the vibrational density of states at 57 +/- 2 K, which is absent in the unfilled skutterudite CoSb3. Heat capacity measurements on Tl0.8Co4Sb11Sn as compared to CoSb3 are consistent with the presence of a localized vibrational mode associated with the "rattling" thallium atoms in this filled skutterudite compound. Both results are well described by a localized Einstein mode model with an Einstein temperature Theta(E) of 53 +/- 1 K. These data provide perhaps the clearest example of local mode behavior in a concentrated metallic system. [less ▲]

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See detailLa problématique de la résistance des pneumocoques aux antibiotiques
Marchal, Valérie; Melin, Pierrette ULiege; Hayette, Marie-Pierre ULiege et al

in Revue Médicale de Liège (2003), 58(11), 675-680

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and it is also a common cause of sinusitis, otitis media, bacteremia and meningitis. The increasing resistance to ... [more ▼]

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and it is also a common cause of sinusitis, otitis media, bacteremia and meningitis. The increasing resistance to antimicrobial agents, now endemic in many countries, reflects an uncontrolled use of antibiotics. A good antibiotics policy and vaccination are at the moment the only way to control efficaciously the increasing antibiotic resistance of Streptococcus pneumoniae [less ▲]

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