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See detailL'image du mois. Malacoplasie pulmonaire a Rhodococcus equi chez un patient atteint du SIDA.
Delbecque, Katty ULg; Radermecker, Maurice ULg; Leonard, Philippe ULg et al

in Revue Médicale de Liège (2002), 57(11), 685-7

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See detailAre time-based and event-based prospective memory affected by normal aging in the same way ?
Bastin, Christine ULg; Meulemans, Thierry ULg

in Current Psychology Letters: Behavious, Brain and Cognition (2002), 7

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See detailMise au point d'un modèle cartographique pour la description des stations forestières en Ardenne belge.
Claessens, Hugues ULg; Lejeune, Philippe ULg; Cuvelier, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(4), 209-220

The paper presents an original method dealing with the forest site types delineation. The suggested method consists in integrating a typological key in a GIS aiming at producing a thematic map that ... [more ▼]

The paper presents an original method dealing with the forest site types delineation. The suggested method consists in integrating a typological key in a GIS aiming at producing a thematic map that describes forest site types. Data used are the soil map of Belgium (digitized at the scale 1:20,000) and a digital elevation model built from a topographic map (scale 1:10,000). The typological key is mainly based on the methodology used by Thill et al. (1988) in the site types system for central Ardenne, the potential vegetation map of Sougnez and Dethioux (1975) and the ecoregion map of Delvaux and Galoux (1962). In that respect, site types are closely linked to the soil map and the phytosociological classification. So, they can be connected to the afforestation guide and different phytosociological and autecological studies concerning forest species. It is then possible to map the potential habitats or the site potentialities related to tree species. The key is valid for the Ardenne ecoregion located in Southern Belgium (elevation higher than 300 m). It has to be validated through an intensive use in the field, taking into account its imprecision linked to the types of collected data, chieffly those being digitized. The integration of such a tool in a SIG can be considered as an original way in terms of integrated forest management or forest sites description in the context of the project “Natura 2000” launched by the European Union. The study has been carried out within the framework of an experimental integrated management project concerning the Saint-Hubert forest (17,000 ha). [less ▲]

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See detailFeasibility of a Walloon test-day model and study of its potential as tool for selection and management
Auvray, B.; Gengler, Nicolas ULg

in Interbull Bulletin (2002), 29

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See detailRumen Escape Of Methionine And Lysine Administered Intraruminally To Growing Double-Muscled Belgian Blue Bulls
Froidmont, Eric; Rondia, Pierre; Thewis, André ULg et al

in Reproduction Nutrition Development (2002), 42(6), 537-544

In many dietary conditions, methionine (Met) and lysine (Lys) are the most limiting amino acids (AA) for ruminants. The AA protected from ruminal fermentation are not commercially available, with the ... [more ▼]

In many dietary conditions, methionine (Met) and lysine (Lys) are the most limiting amino acids (AA) for ruminants. The AA protected from ruminal fermentation are not commercially available, with the exception of Met which is not always economical, especially for meat production. This study measured ruminal escape of free Met and Lys supplemented intraruminally to fast growing bulls. Six double-muscled Belgian Blue bulls, fed a high concentrate diet and fitted with a rumen cannula, received free Met (40 g.d–1) and free Lys (60 g.d–1), individually or simultaneously, in a duplicated Latin square design. The mean ruminal escape of Met and Lys reached 37 and 45% respectively, and did not differ if administered separately or together. Plasma Lys and Met concentrations were increased by 504 and 126%, respectively. Substantial proportions of free AA escaped ruminal fermentation and were available for absorption from the small intestine when they were administered at physiologically high levels. [less ▲]

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See detailMultiple pulmonary arteriovenous malformations.
Quaden, C.; Ghaye, Benoit ULg; Dondelinger, Robert ULg et al

in Lancet (2002), 359(9322),

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See detailA Set Of Primers For Amplification Of Mitochondrial Dna In Picea Abies And Other Conifer Species
Jeandroz, S.; Bastien, D.; Chandelier, A. et al

in Molecular Ecology Notes (2002), 2(4),

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See detailLe mélèze, un bois de qualité aux multiples usages
Charron, Stéphane; Hebert, Jacques ULg; Jourez, Benoît ULg

in Forêt Wallonne (2002), (61), 37-41

Réputé pour son aspect esthétique, sa résistance mécanique et sa durabilité naturelle, le mélèze est une essence polyvalente, apte à de multiples usages tant intérieurs qu’extérieurs. Pourtant ... [more ▼]

Réputé pour son aspect esthétique, sa résistance mécanique et sa durabilité naturelle, le mélèze est une essence polyvalente, apte à de multiples usages tant intérieurs qu’extérieurs. Pourtant, l’industrie de la transformation belge ne s’y est pas beaucoup intéressée. <br />Plusieurs explications peuvent être évoquées : faibles volumes commercialisés, mauvaise réputation en raison de quelques expériences malheureuses, <br />etc. Actuellement, les préjugés s’estompent et la demande en bois de mélèze est croissante. [less ▲]

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See detailAdhesion of synchronized human hematopoietic progenitor cells to fibronectin and vascular cell adhesion molecule-1 fluctuates reversibly during cell cycle transit in ex vivo culture.
Huygen, Sandra; Giet, Olivier ULg; Artisien, Vincent et al

in Blood (2002), 100(8), 2744-52

Ex vivo expansion of hematopoietic stem/progenitor cells may result in defective engraftment. Human cord blood CD34(+) progenitor cells were synchronized and assayed for adhesion and migration onto ... [more ▼]

Ex vivo expansion of hematopoietic stem/progenitor cells may result in defective engraftment. Human cord blood CD34(+) progenitor cells were synchronized and assayed for adhesion and migration onto fibronectin (Fn) and vascular cell adhesion molecule-1 (VCAM-1) at different stages of a first cell cycle executed ex vivo. During S phase transit, adhesion to Fn was transiently increased while binding to VCAM-1 was reversibly decreased, after which adhesion to both ligands returned to baseline levels with cell cycle completion. Transmigration across Fn and VCAM-1 decreased irreversibly during S phase progression. The function of alpha4 and alpha5 integrins was assessed with specific neutralizing antibodies. In uncultured CD34(+) cells and long-term culture-initiating cells (LTC-ICs), both adhesion and migration on Fn were inhibited by anti-alpha4 but not by anti-alpha5 antibodies. In mitotically activated CD34(+) cells and LTC-ICs, adhesion and migration on Fn were mainly dependent on alpha5 integrin and to a lesser extent on alpha4 integrin. Changes in integrin function were not dependent on parallel modulation of integrin expression. In conclusion, Fn and VCAM-1 binding of progenitor cells fluctuates reversibly during cell cycle transit ex vivo. In addition, our data show that mitogenic activation induces a shift from a dominant alpha4 to a preferential alpha5 integrin-dependent interaction with Fn. [less ▲]

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See detailVers de nouveaux modes de communication sur les risques
Brunet, Sébastien ULg; hupet, Pierre

in Sécurité au travail (2002), n°100(1), 566-573

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See detailCambios en la participación política de los inmigrantes en la región de Bruselas capital. Elecciones de octubre de 2000
Martiniello, Marco ULg; Jacobs, Dirk; Rea, Andrea

in Revista Migraciones (2002), 11

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See detailAutoimmune sensorineural hearing loss improved by tumor necrosis factor-alpha blockade: a case report.
Staecker, H.; Lefèbvre, Philippe ULg

in Acta Oto-Laryngologica (2002), 122(6), 684-7

Autoimmune inner ear disease is a treatable cause of sensorineural hearing loss and it is important for physicians and hearing health professionals to recognize that early diagnosis and proper management ... [more ▼]

Autoimmune inner ear disease is a treatable cause of sensorineural hearing loss and it is important for physicians and hearing health professionals to recognize that early diagnosis and proper management strategies may result in stabilization and improvement in hearing. The pathogenesis of autoimmune sensorineural hearing loss remains unclear but antibodies directed against the inner ear and/or cellular effectors have been proposed. Therefore, immunosuppressive drugs such as steroids and methotrexate are administered to interfere with the progression of hearing loss and in some cases have been found to improve hearing. We report herein the history of a patient who was treated by systemic administration of anti-tumor necrosis factor-alpha antibodies for Crohn's disease and who also had associated sensorineural hearing loss. Audiometric follow-up revealed not only the efficacy of tumor necrosis factor-alpha blockade in arresting the hearing loss but also an improvement in hearing of 15 dB on average across all frequencies. Hearing remained stable afterwards. [less ▲]

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See detailNew trends in dual 5-LOX/COX inhibition
De Leval, X.; Julémont, F.; Delarge, J. et al

in Current Medicinal Chemistry (2002), 9

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See detailATP-driven, Na(+)-independent inward Cl- pumping in neuroblastoma cells
Bettendorff, Lucien ULg; Lakaye, Bernard ULg; Margineanu, Ilca et al

in Journal of Neurochemistry (2002), 81(4), 792-801

In immature neurones, the steady-state intracellular Cl- concentration [Cl-](i) is generally higher than expected for passive distribution, and this is believed to be due to Na(+)-K(+)-2Cl(-) co-transport ... [more ▼]

In immature neurones, the steady-state intracellular Cl- concentration [Cl-](i) is generally higher than expected for passive distribution, and this is believed to be due to Na(+)-K(+)-2Cl(-) co-transport. Here, we show that N2a neuroblastoma cells, incubated in HEPES-buffered NaCl medium maintain a [Cl-](i) around 60 mm, two- to threefold higher than expected for passive distribution at a membrane potential of - 49 mV. When the cells were transferred to a Cl(-) -free medium, [Cl-](i) decreased quickly (t(1/2) < 5 min), suggesting a high Cl- permeability. When the intracellular ATP concentration was reduced to less than 1 mm by metabolic inhibitors, the initial rate of (36) Cl- uptake was strongly inhibited (60-65%) while steady-state [Cl-](i) decreased to 24 mm, close to the value predicted from the Nernst equilibrium. Moreover, after reduction of [ATP](i) and [Cl-](i) by rotenone, the subsequent addition of glucose led to a reaccumulation of Cl-, in parallel with ATP recovery. Internal bicarbonate did not affect Cl- pumping, suggesting that Cl-/HCO(3)(-) exchange does not significantly contribute to active transport. Likewise, Na(+) -K(+) -2Cl(-) co-transport also appeared to play a minor role: although mRNA for the NKCC1 form of the co-transporter was detected in N2a cells, neither the initial rate of (36)Cl- uptake nor steady-state [Cl-](i) were appreciably decreased by 10 microm bumetanide or replacement of external Na(+) by choline. These results suggest that a highly active ATP-dependent mechanism, distinct from Na(+) -K(+) -2Cl(-) co-transport, is responsible for most of the inward Cl- pumping in N2a cells. [less ▲]

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See detailDe zinsaccentuering in de tussentaal van Franstalige leerders van het Nederlands
Hiligsmann, Philippe; Rasier, Laurent ULg

in N/F (2002), 1

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See detailComment je traite ... la paralysie faciale par anastomose hypoglosso-faciale.
Courtmans, I; Born, J D; CARLIER, Alain ULg et al

in Revue Médicale de Liège (2002), 57(1), 3-6

Thirteen patients underwent a hypoglosso- or a spino-facial nerve anastomosis between 1990 and 1996. Facial palsy was the result of surgery in 12 cases and of radiosurgery in 1 case. The mean interval ... [more ▼]

Thirteen patients underwent a hypoglosso- or a spino-facial nerve anastomosis between 1990 and 1996. Facial palsy was the result of surgery in 12 cases and of radiosurgery in 1 case. The mean interval between facial palsy and anastomosis was 12 months. Facial nerve function is determined on the basis of clinical examination according to the classification of House-Brackmann and our own evaluation. According to House, 10 patients are classified grade III and 3 grade IV. Our evaluation defines in 10 grade III, 7 good results and 3 fair results. As far as the good results are concerned, the mean interval between palsy and anastomosis is short (< 3 months). The permanent eating and swallowing dysfunctions are consecutive to multiple cranial nerve deficits. The post-paralysis hemifacial spasm is facilitated by prolongated electric stimulations. [less ▲]

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See detailChanges in motor unit numbers in patients with ALS: a longitudinal study using the adapted multiple point stimulation method.
Wang, François-Charles ULg; Bouquiaux, Olivier ULg; De Pasqua, Victor ULg et al

in Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders (2002), 3(1), 31-8

METHOD: The adapted multiple point stimulation (AMPS) method for calculating motor unit numbers (MUNE) was applied in 12 patients with amyotrophic lateral sclerosis (ALS) before riluzole therapy (T(0 ... [more ▼]

METHOD: The adapted multiple point stimulation (AMPS) method for calculating motor unit numbers (MUNE) was applied in 12 patients with amyotrophic lateral sclerosis (ALS) before riluzole therapy (T(0)) and again after 4, 8 and 12 months of treatment. RESULTS: Paired Student's t-test indicated a significant decrease of thenar MUNE and compound muscle action potential (CMAP) size at each 4-monthly interval, while average surface motor unit potential (SMUP) size did not change significantly over time. The rate of motor unit (MU) loss at month 4 was more than 20% in six patients (group 1) and less than 20% in six other patients (group 2). Comparison of groups 1 and 2 by Mann-Whitney U-testing indicated that percent changes in thenar MUNE and CMAP size compared to baseline were significantly different at months 4, 8 and 12, while no difference between the two groups was found for average SMUP size variations. In the group with a slow rate of MU loss, CMAP size remained stable, while in the group with a rapid rate of MU loss, there was a dramatic reduction in size of the CMAP. A positive correlation was found between percent change in thenar MUNE at T(4) and at T(12) (P < 0.001). CONCLUSION: AMPS is a useful technique to document MUNE, SMUP size and CMAP size changes over time in patients with ALS. [less ▲]

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See detailEclatement des mobilités d'achats et recomposition des territoires : le cas de l'Ardenne du Nord-Est.
Schmitz, Serge ULg; Halleux, Jean-Marie ULg

in Mosella (2002), 26(3-4), 425-432

Lived world are structured by regular journeys. Many journeys are constrained, other, such as shopping mobilities, present a higher level of freedom. New mobilities and new commercial localisation ... [more ▼]

Lived world are structured by regular journeys. Many journeys are constrained, other, such as shopping mobilities, present a higher level of freedom. New mobilities and new commercial localisation strategies lead to new travels network. The aim of the paper is to study shopping behaviours in North-Eastern Ardennes in order to underline the increasing disparities between shopping mobilities, lived world, homeland and institutional territories. When space behaviours make and remake territorial frames. [less ▲]

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See detailLa clé des champs au risque de mettre la clé sous la porte
Graas, Christelle; Noel, Véronique; argento, gino et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2002), 5

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See detailThe role of aminosalicylates in the treatment of ulcerative colitis.
Van Assche, Gert; Baert, Filip; De Reuck, Marc et al

in Acta Gastro-Enterologica Belgica (2002), 65(4), 196-9

Aminosalicylates (5-ASA, sulfasalazine and mesalazine) play a central role in the treatment of ulcerative colitis (UC). For acute treatment of mild to moderate flares and in maintenance treatment, their ... [more ▼]

Aminosalicylates (5-ASA, sulfasalazine and mesalazine) play a central role in the treatment of ulcerative colitis (UC). For acute treatment of mild to moderate flares and in maintenance treatment, their efficacy has been established. Since ulcerative colitis is limited to the distal colon in two thirds of the patients, topical therapy also plays an important role. In mild/moderate active disease 5-ASA 4 g/d is as effective as oral corticosteroids. Ulcerative proctitis is treated with 2 x 500 mg or 1 x 1 g suppositories and proctosigmoiditis with 1 to 4 g enemas. Oral 5-ASA is also safe in maintenance treatment and is generally well tolerated. The risk of colorectal tumours is increased in patients with longstanding ulcerative colitis and epidemiological evidence indicates that chronic 5-ASA treatment reduces this risk. However, at present there is insufficient evidence to maintain patients on life-long 5-ASA maintenance treatment for this indication. [less ▲]

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See detailÉtude dendrométrique d’Acacia auriculiformis A. Cunn. ex Benth. en mélange sur vertisol au Bénin
Fonton, N. H.; Glele Kakai, R.; Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(1), 29-37

Acacia auriculiformis is a fast growing species planted on vertisols in Benin. An inventory of 11 mixed stands of Acacia, which are 7 to 9 years old, has been realized to estimate growth parameters of the ... [more ▼]

Acacia auriculiformis is a fast growing species planted on vertisols in Benin. An inventory of 11 mixed stands of Acacia, which are 7 to 9 years old, has been realized to estimate growth parameters of the stands. The present study shows that, for the dendrometrical parameters, there is no difference between species associations at a 0.05 significance level. Nevertheless, the largest values of quadratic mean diameter of the stems foot are observed in the species associations including Leucaena leucocephala. Moreover, the branch volume decreases with the increasing of the number of stems per tree. The most appropriate volume function for Acacia auriculiformis is the one that takes into account the diameter of the stems foot and the total height. Otherwise, the species associations do not influence the profile of Acacia trees, which is constant within the associations. The predicted conversion and cutting coefficients show that the stacked wood volume represents about 144 % of the real stand volume. [less ▲]

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See detailL’authenticité iconographique des portails occidentaux de la cathédrale de Strasbourg
Van den Bossche, Benoît ULg

in Bulletin de la Cathédrale de Strasbourg (2002), 15

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See detailIncreased fecundity of malathion-specific resistant beetles in absence of insecticide pressure
Arnaud, Ludovic; Brostaux, Yves ULg; Assie, Lazare Komenan et al

in Heredity (2002), 89(6), 425-429

Despite that resistance frequency is assumed to decline when selective pressure is relaxed, the stability of resistance frequency has been observed in some insects in the absence of insecticide. In the ... [more ▼]

Despite that resistance frequency is assumed to decline when selective pressure is relaxed, the stability of resistance frequency has been observed in some insects in the absence of insecticide. In the red flour beetle, Tribolium castaneum, the first case of malathion-resistance was reported in the early 1960s. The malathion-specific resistant phenotype has now almost completely replaced the susceptible one in red flour beetle populations. In the present study, several life-history traits that could influence the fitness of the insects were compared between insecticide-susceptible and malathion-specific resistant populations of the red flour beetle. On average, egg fertility and egg-to-adult development time did not differ between susceptible and resistant populations. However, the fecundity of resistant females was greater than that of susceptible ones. Generally, differences in development time between insecticide resistant and susceptible populations are considered as having more effect on fitness than do differences in fecundity. However, the observed increased female fecundity may participate, in combination with the previously observed increased male reproductive success, to the development and the stability of malathion-specific resistance in T. castaneum. [less ▲]

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See detailReview of present European environmental policies and legislation involving cultural heritage
Teller, Jacques ULg; Bond, Alan

in Environmental Impact Assessment Review (2002), 22

Cultural heritage is being addressed by a number of Charters and Conventions and it is clear that its consideration within decision-making processes is progressively becoming a real challenge, both for ... [more ▼]

Cultural heritage is being addressed by a number of Charters and Conventions and it is clear that its consideration within decision-making processes is progressively becoming a real challenge, both for developers and public authorities. Against this background, this paper reviews the environmental assessment framework developed by the European Community, as this should increasingly influence decision making about cultural heritage in an urban setting. The legislative framework for access to environmental information is also reviewed because of its relevance to the decision-making process. The Directives on Environmental Impact Assessment and Strategic Environmental Assessment both require a consideration of cultural heritage in decision making. This requirement can go some way to addressing the paradox in the European Community’s position whereby the Community wishes to conserve and enhance its own cultural identity whilst, at the same time, cultural heritage is usually defined at a local level. The present paper suggests that, given their flexibility, the two European Community Directives on environmental assessment constitute a promising opportunity to address this seeming paradox, but that there is a significant gap between legal obligations and the methodological tools to meet them. [less ▲]

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See detailAsymmetric dihydroxylation of C,C double bonds using catalytic amounts of osmium tetroxide, selenides, and air
Krief, A.; Colaux, Catherine ULg

in Pure & Applied Chemistry (2002), 74(1), 107-113

Selenides, selenoxides, osmium tetroxide, and potassium osmate dihydrate are in equilibrium in aqueous tert-butanol containing potassium carbonate. We took advantage of this feature to withdraw the ... [more ▼]

Selenides, selenoxides, osmium tetroxide, and potassium osmate dihydrate are in equilibrium in aqueous tert-butanol containing potassium carbonate. We took advantage of this feature to withdraw the equilibrium in each of the two directions to produce allylalcohols from allylselenides and diols from olefins. The latter reaction performed in the presence of catalytic amounts of Cinchona alkaloids and osmium tetroxide allows the enantioselective dihydroxylation of C,C double bonds. [less ▲]

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See detailTNF-alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB
Relic, Biserka ULg; Bentires-Alj, Mohamed; Ribbens, Clio ULg et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2002), 82(12), 1661-1672

TNF-alpha plays a key role in rheumatoid arthritis, but its effect on chondrocyte survival is still conflicting. In the present study, we tested how TNF-alpha influences chondrocyte survival in response ... [more ▼]

TNF-alpha plays a key role in rheumatoid arthritis, but its effect on chondrocyte survival is still conflicting. In the present study, we tested how TNF-alpha influences chondrocyte survival in response to nitric oxide (NO)-related apoptotic signals, which are abundant during rheumatoid arthritis. Human primary articular chondrocytes or cartilage explants were pretreated with TNF-alpha for 24 hours and then treated with the proapoptotic NO donor sodium-nitro-prusside (SNP) for an additional 24 hours. TNF-alpha pretreatment markedly protected chondrocytes from SNP-induced cell death. Preincubation of chondrocytes with TNF-alpha inhibited both SNP-induced high-molecular weight DNA fragmentation and annexin V-FITC binding. Of interest, TNF-alpha induced persistent nuclear factor-kappaB (NF-kappaB)-DNA binding activity even in the presence of SNP, mirroring apoptosis protection effects. Both the TNF-alpha antiapoptotic effect and NF-kappaB-DNA binding activity were significantly inhibited by NF-kappaB inhibitors, Bay 11-7085, MG-132, and adenovirus-expressing mutated IkappaB-alpha. Phosphatidylinositol-3 kinase inhibitor LY 294002 also markedly inhibited the antiapoptotic effect of TNF-alpha. In primary chondrocytes, TNF-alpha induced expression of the antiapoptotic protein Cox-2, which persisted in the presence of SNP, and a specific Cox-2 inhibitor significantly blocked the TNF-alpha protective effect. We therefore conclude that TNF-alpha-mediated protection of chondrocytes from NO-induced apoptosis acts through NF-kappaB and requires Cox-2 activity. [less ▲]

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See detailDes pratiques aux performances : la littératie chez les jeunes de 15 ans
Lafontaine, Dominique ULg

in Lettre de la DFLM (La) (2002), 30

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See detailMembrane Destabilization Induced By Beta-Amyloid Peptide 29-42: Importance Of The Amino-Terminus
Mingeot-Leclercq, Mp.; Lins, Laurence ULg; Bensliman, M. et al

in Chemistry and Physics of Lipids (2002), 120(1-2), 57-74

Increasing evidence implicates interactions between Abeta-peptides and membrane lipids in Alzheimer's disease. To gain insight into the potential role of the free amino group of the N-terminus of Abeta29 ... [more ▼]

Increasing evidence implicates interactions between Abeta-peptides and membrane lipids in Alzheimer's disease. To gain insight into the potential role of the free amino group of the N-terminus of Abeta29-42 fragment in these processes, we have investigated the ability of Abeta29-42 unprotected and Abeta29-42 N-protected to interact with negatively-charged liposomes and have calculated the interaction with membrane lipids by conformational analysis. Using vesicles mimicking the composition of neuronal membranes, we show that both peptides have a similar capacity to induce membrane fusion and permeabilization. The fusogenic effect is related to the appearance of non-bilayer structures where isotropic motions occur as shown by 31P and 2H NMR studies. The molecular modeling calculations confirm the experimental observations and suggest that lipid destabilization could be due to the ability of both peptides to adopt metastable positions in the presence of lipids. In conclusion, the presence of a free or protected (acetylated) amino group in the N-terminus of Abeta29-42 is therefore probably not crucial for destabilizing properties of the C-terminal fragment of Abeta peptides. [less ▲]

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See detailProlégomènes à l'étude de la Schola du Trajan à Ostie.
Morard, Thomas ULg; Wavelet, David

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2002), 114(2), 759-815

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See detailInitiation à une pédagogie active de l'éveil scientifique : analyse d'une démarche d'observation en formation continuée d'enseignants
Geurden, Christine; Hanck, Marianne; Giot, Bernadette ULg et al

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 9-10

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See detailEvidence for a persistent and extensive greening trend in Eurasia inferred from satellite vegetation index data.
Bogaert, Jan ULg; Zhou, L; Tucker, C J et al

in Journal of Geophysical Research (2002), 107(D11),

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See detailRapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
Limbourg, Florian P; Huang, Zhihong; Plumier, Jean-Christophe ULg et al

in Journal of Clinical Investigation (2002), 110(11), 1729-38

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate ... [more ▼]

Many cellular responses to corticosteroids involve the transcriptional modulation of target genes by the glucocorticoid receptor (GR). A rapid, non-nuclear effect of GR was found to mediate neuroprotection. High-dose corticosteroids (20 mg/kg intraperitoneally), given within 2 hours of transient cerebral ischemia, acutely increased endothelial nitric oxide synthase (eNOS) activity, augmented regional cerebral blood flow (CBF) by 40% to 50%, and reduced cerebral infarct size by 32%. These neuroprotective effects of corticosteroids were abolished by the GR antagonist RU486 and by inhibition of phosphatidylinositol 3-kinase (PI3K), and were absent in eNOS(-/-) mice. To determine the mechanism by which GR activated eNOS, we measured the effect of corticosteroids on PI3K and the protein kinase Akt. In a ligand-dependent manner, GR activated PI3K and Akt in vitro and in vivo caused NO-dependent vasodilation, which was blocked by cotreatment with RU486 or the PI3K inhibitor LY294002 but not by transcriptional inhibitors. Indeed, a mutant GR, which cannot dimerize and bind to DNA, still activated PI3K and Akt in response to corticosteroids. These findings indicate that non-nuclear GR rapidly activates eNOS through the PI3K/Akt pathway and suggest that this mechanism mediates the acute neuroprotective effects of corticosteroids through augmentation of CBF. [less ▲]

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See detailEvaluation de la composition de la carcasse et de la qualité de la viande par ultrasonographie chez le porc
Youssao, A. K. L.; Verleyen, Vincent ULg; Leroy, Pascal ULg

in Annales de Médecine Vétérinaire (2002), 146(1), 19-29

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See detailThe novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener
Dabrowski, M.; Ashcroft, F. M.; Ashfield, R. et al

in Diabetes (2002), 51

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See detailSociologie de la littérature. La question de l'illégitime
Bertrand, Jean-Pierre ULg; Denis, Benoît ULg

in Lieux Littéraires / La Revue (2002), (5),

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See detailJuvenile acanthosis nigricans and insulin resistance.
Hermanns-Lê, Trinh ULg; Hermanns, Jean-François ULg; Pierard, Gérald ULg

in Pediatric Dermatology (2002), 19(1), 12-4

Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. In the early stage the skin lesions appeared to be ... [more ▼]

Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. In the early stage the skin lesions appeared to be erythematous and pruritic, mimicking an inflammatory dermatitis. Dietary control and oral metformin hydrochloride markedly improved the lesions. Topical calcipotriol may also help to control the skin condition. [less ▲]

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See detailOver Kalligramme. Zur Medialität einer Schrift anhand von Paul van Ostaijens De feesten van angst en pijn
Spinoy, Erik ULg

in Spiegel der Letteren (2002), 44(3), 291-293

This is a review of a study by Sonja Neef on the work of Paul van Ostaijen

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See detailPositron emission tomography in non-Hodgkin's lymphoma (NHL): relationship between tracer uptake and pathological findings, including preliminary experience in the staging of low-grade NHL.
Jerusalem, Guy ULg; Beguin, Yves ULg

in Clinical Lymphoma (2002), 3(1), 56-61

Advances in imaging techniques have allowed more precise staging and better evaluation of the effect of new treatment modalities. The limitations of conventional morphologic imaging techniques are well ... [more ▼]

Advances in imaging techniques have allowed more precise staging and better evaluation of the effect of new treatment modalities. The limitations of conventional morphologic imaging techniques are well known. Positron emission tomography (PET) using fluorine-18-labeled fluorodeoxyglucose is now routinely used for initial staging and re-evaluation during or after treatment of Hodgkin's disease and aggressive non-Hodgkin's lymphoma (NHL), but not in low-grade NHL. In the first part of this review, the relationship between glucose metabolism as measured by PET, pathological findings including histological grade and proliferative activity, and prognosis are analyzed. In the second part, the potential role of PET in the staging and follow-up of low-grade NHL is discussed. Published data indicate that PET may contribute to the management of low-grade follicular NHL. [less ▲]

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See detailDeriving lactation yields from test-day yields adjusted for lactation stage, age, pregnancy, and herd test date
Wiggans, G. R.; VanRaden, P. M.; Bormann, J. et al

in Journal of Dairy Science (2002), 85

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See detailLes frais supportés par l'adjudicataire en cas de saisie-exécution immobilière
Georges, Frédéric ULg

in Journal des Tribunaux (2002)

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See detailRhoA inhibition is a key step in pituicyte stellation induced by A(1)-type adenosine receptor activation.
Rosso, Lia; Peteri-Brunback, Brigitta; Vouret-Craviari, Valerie et al

in Glia (2002), 38(4), 351-62

Pituicyte stellation in vitro represents a useful model with which to study morphological changes that occur in vivo in these cells during times of high neurohypophysial hormone output. This model has ... [more ▼]

Pituicyte stellation in vitro represents a useful model with which to study morphological changes that occur in vivo in these cells during times of high neurohypophysial hormone output. This model has helped us establish the hypothesis of a purinergic regulation of pituicyte morphological plasticity. We first show that ATP induces stellation in 37% of pituicytes, an effect that is secondary to the metabolism of ATP to adenosine. Adenosine-induced stellation of pituicytes appears to be mediated by A(1)-type receptors. The effect is independent of intracellular calcium and does not involve the mitogen-activated protein kinase pathway. The basal (nonstellate) state of pituicytes depends on tonic activation of a Rho GTPase because both C3 transferase (a Rho inhibitor) and Y-27632 (an inhibitor of p160Rho kinase) can induce stellation. Lysophosphatidic acid, a Rho activator, blocks the morphogenic effect of adenosine dose-dependently. Using a specific RhoA pull-down assay, we also show that downregulation of activated RhoA is the key event coupling A(1) receptor activation to pituicyte stellation, via F-actin depolymerization and microtubule reorganization. Finally, both vasopressin and oxytocin can prevent or reverse adenosine-induced stellation. The effects of vasopressin, and those of high concentrations of oxytocin, are mediated through V(1a) receptors. Placed within the context of the relevant literature, our data suggest the possibility of a purinergic regulation of pituicyte morphological plasticity and subsequent modulation of hormone release, with these hormones providing a negative feedback mechanism. [less ▲]

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See detailDermo-epidermal stimulation elicited by a salicylic acid derivative: a comparison with salicylic acid and all trans-retinoic acid.
Pierard, Gérald ULg; Leveque, J.-L.; Rougier, A. et al

in European Journal of Dermatology (2002), 12(4), -

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See detailQuelques considérations techniques sur la construction, les transformations et l'état matériel de la tour valenciennoise, à Mons
Houbart, Claudine ULg

in Mémoires et Publications de la Société des Sciences, des Arts et des Lettres du Hainaut (2002), CI

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See detailPistes de réflexion pour développer, à l’école, les compétences de tous les élèves
Beckers, Jacqueline ULg

in L’École valdôtaine (2002), 55

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See detailInfluence of the metal electronic properties on the sum-frequency generation spectra of dodecanethiol self-assembled monolayers on Pt (111), Ag (111) and Au (111) single crystals
Dreesen, Laurent ULg; Humbert, Christophe; Celebi, M. et al

in Applied Physics B : Lasers & Optics (2002), 74

Infrared-visible sum-frequency generation (SFG) spectroscopy is performed at different visible wavelengths between 450 and 650 nm in order to investigate the interaction between metallic substrates (Pt ... [more ▼]

Infrared-visible sum-frequency generation (SFG) spectroscopy is performed at different visible wavelengths between 450 and 650 nm in order to investigate the interaction between metallic substrates (Pt, Ag and Au) and 1-dodecanethiol self-assembled monolayers. We show that such measurements provide a means to study the electronic properties of metals as well as the interference phenomena between the SFG signals from the adsorbate and the substrate. The common features of the three interfaces are the vibration modes of the terminal methyl groups. However, these resonances appear as peaks for Pt (111) and as dips in the case of Ag (111). Their shape is not modified when the visible wavelength is tuned between 450 and 650 nm. Moreover, the metal sum-frequency generation contribution is slightly modified in that spectral range. For Au (111) samples, the sum-frequency generation spectrum drastically evolves with the visible wavelength: the peak resonant sum-frequency generation signal at 450 nm becomes rather dip-shaped at 650 nm. The non-linear response of gold is also enhanced when the wavelength associated with the sum-frequency process is close to 480 nm. These results are interpreted on the basis of the metal electronic properties that are responsible for the non-resonant contribution to the SFG signal. [less ▲]

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See detailEnzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
Fischle, Wolfgang; Dequiedt, Franck ULg; Hendzel, Michael J et al

in Molecular Cell (2002), 9(1), 45-57

Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression. The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered necessary and sufficient for ... [more ▼]

Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression. The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered necessary and sufficient for enzymatic activity. Here, we show that the catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor N-CoR/SMRT. All experimental conditions leading to the suppression of HDAC4 binding to SMRT/N-CoR and to HDAC3 result in the loss of enzymatic activity associated with HDAC4. In vitro reconstitution experiments indicate that HDAC4 and other class II HDACs are inactive in the context of the SMRT/N-CoR-HDAC3 complex and do not contribute to its enzymatic activity. These observations indicate that class II HDACs regulate transcription by bridging the enzymatically active SMRT/N-CoR-HDAC3 complex and select transcription factors independently of any intrinsic HDAC activity. [less ▲]

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See detailPrenons garde aux lésions kystiques cutanées. Du dérisoire au méritoire.
Hermanns-Lê, Trinh ULg; Hermanns, Jean-François ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(5), 314-6

Cutaneous cystic-like lesions do not always correspond to real epithelial cysts. Indeed, the histological examination may identify another benign tumour. But, in some instances, the surprise may be ... [more ▼]

Cutaneous cystic-like lesions do not always correspond to real epithelial cysts. Indeed, the histological examination may identify another benign tumour. But, in some instances, the surprise may be greater. We report three patients in whom lesions suggested clinically small cysts. However, they were malignant neoplasms corresponding to a malignant fibrous histiocytoma, an epithelioid angiosarcoma and a metastatic adenocarcinoma, respectively. [less ▲]

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See detailPrélèvement de l’isthme encéphalique pour la recherche de l’encéphalopathie spongiforme transmissible chez le mouton
Gabriel, Annick ULg; Jacobs, Christine ULg; Simoens, P.

in Annales de Médecine Vétérinaire (2002), 146(5), 295-300

Depuis le premier avril 2002, une directive de l'Union Européenne contraint la Belgique à tester les chèvres et les moutons, en plus des bovins, dans le cadre de la recherche d'encéphalopathie spongiforme ... [more ▼]

Depuis le premier avril 2002, une directive de l'Union Européenne contraint la Belgique à tester les chèvres et les moutons, en plus des bovins, dans le cadre de la recherche d'encéphalopathie spongiforme transmissible. Comme chez les bovins, le diagnostic est réalisé à partir d'un prélèvement de l'isthme encéphalique au niveau de l'obex. Des différences morphologiques entre l'isthme encéphalique des moutons et chèvres et celui des bovins ont nécessité quelques ajustements de la méthode de prélèvement. Dans cette étude, les particularités techniques du prélèvement et certaines caractéristiques morphologiques du cerveau ovin sont décrites. Les différences majeures, par rapport aux bovins, sont d'une part les dimensions plus petites, et d'autre part le rétrécissement caudal très marqué de l'isthme encéphalique. [less ▲]

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See detailThe use of blood pepsinogen as a biomarker of the integrity of the porcine gastric mucosa : A review. Part 1: History, physiopathology of gastric mucosa and different forms of pepsinogens
Banga-Mboko, Henri; Godeau, Jean-Marie ULg; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (2002), 146(6), 339-346

Because the history is defined as the account of the passed events, this manuscript is an Update research on swine pepsinogens since their discovery by Theodor Schwann. Progress was particularly made in ... [more ▼]

Because the history is defined as the account of the passed events, this manuscript is an Update research on swine pepsinogens since their discovery by Theodor Schwann. Progress was particularly made in the localization within the gastric mucosa membrane of the specialized cells involved in the secretion of pepsinogens. These progresses also included identification, isolation purification and the classification of the zymogens. [less ▲]

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See detailUreteral endometriosis: a complication of rectovaginal endometriotic (adenomyotic) nodules
Donnez, Jacques; NISOLLE, Michelle ULg; Squifflet, Jean

in Fertility and Sterility (2002), 77(1), 32-37

Objective: To present data from 18 cases of ureteral endometriosis. Design: Prospective clinical study. Setting: Department of gynecology at a university hospital. Patient(s): Four hundred and five ... [more ▼]

Objective: To present data from 18 cases of ureteral endometriosis. Design: Prospective clinical study. Setting: Department of gynecology at a university hospital. Patient(s): Four hundred and five patients with severe dysmenorrhea or deep dyspareunia due to a rectovaginal endometriotic (adenomyotic) nodule. Intervention(s): Patients were prospectively evaluated using intravenous pyelography. All patients underwent laparoscopic surgery to remove rectovaginal adenomyosis and ureterolysis. Main Outcome Measure(s): Presurgical and postsurgical evaluation and histologic analysis. Result(s): Preoperative intravenous pyelography revealed ureteral stenosis with ureterohydronephrosis in 18 patients (4.4%). A significantly higher prevalence (11.2%) was observed in nodules ≥ 3 cm in diameter. Five women (20%) had complete ureteral stenosis. Kidney scintigraphy revealed damaged kidney parenchymal function, which ranged from 18% to 42%. Laparoscopic ureterolysis was done in 16 women; 2 women underwent ureteral resection and uretero-ureterostomy. A significant postoperative decrease in ureterohydronephrosis was noted in all patients; however, renal function improved only slightly. Conclusion(s): Ureteral endometriosis was found in 4.4% of patients with rectovaginal endometriotic (adenomyotic) nodules. Ureterolysis and removal of associated adenomyotic lesions was sufficient therapy in most patients; two required resection of the ureteral stenotic segment. Intravenous pyelography should be performed in all women with rectovaginal nodules ≥ 3 cm to prevent nonreversible loss of renal function. [less ▲]

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See detailA mathematical comment on the formulae for the aggregation index and the shape index.
Bogaert, Jan ULg; Myneni, R B; Knyazikhin, Y

in Landscape Ecology (2002), 17(1), 87-90

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See detailRepeated intracoronary beta radiation for recurrent in-stent restenosis.
De Benedetti, E; Latchem, D; Roguelov, C et al

in Catheterization and Cardiovascular Interventions (2002), 55(2), 233-236

More than 70% of percutaneous coronary interventions are followed by a stent implantation. In-stent restenosis still occurs in 20-30% of patients and remains a therapeutic challenge. At present only ... [more ▼]

More than 70% of percutaneous coronary interventions are followed by a stent implantation. In-stent restenosis still occurs in 20-30% of patients and remains a therapeutic challenge. At present only vascular brachytherapy has been shown to be an effective treatment option. We report here one case of recurrent in-stent restenosis after vascular brachytherapy that was successfully treated by a second beta radiation treatment. Cathet Cardiovasc Intervent 2002;55:233–236. © 2002 Wiley-Liss, Inc. [less ▲]

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See detailDetermination of affinity, stoichiometry and sequence selectivity of minor groove binder complexes with double-stranded oligodeoxynucleotides by electrospray ionization mass spectrometry
Rosu, Frédéric ULg; Gabelica, Valérie ULg; Houssier, Claude ULg et al

in Nucleic Acids Research (2002), 30(16), 82

Electrospray mass spectrometry was evaluated regarding the reliability of the determination of the stoichiometries and equilibrium association constants from single spectra. Complexes between minor groove ... [more ▼]

Electrospray mass spectrometry was evaluated regarding the reliability of the determination of the stoichiometries and equilibrium association constants from single spectra. Complexes between minor groove binders (Hoechst 33258, Hoechst 33342, DAPI, netropsin and berenil) and 12mer oligonucleotide duplexes with a central sequence (A/T)(4) flanked by G/C base pairs were chosen as model systems. To validate the electrospray ionization mass spectrometry (ESI-MS) method, comparisons were made with circular dichroism and fluorescence spectroscopy measurements. ESI-MS allowed the detection of minor (2 drug + DNA) species for Hoechst 33258, Hoechst 33342, DAPI and berenil with duplex d(GGGG(A/T)(4)GGGG). d(CCCC(A/T)(4)CCCC), which were undetectable with the other techniques. Assuming that the duplexes and the complexes have the same electrospray response factors, the equilbrium association constants of the 1:1 and 2:1 complexes were determined by ESI-MS, and the values show a good quantitative agreement with fluorescence determined constants for Hoechst 33258 and Hoechst 33342. It is also shown that ESI-MS can quickly give reliable information on the A/T sequence selectivity of a drug: the signal of a complex is directly related to the affinity of the drug for that particular duplex. The potential of ESI-MS as a qualitative and quantitative affinity screening method is emphasized. [less ▲]

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See detailOxidative stress in equine medicine - Current knowledge
Kirschvink, Nathalie; Lekeux, Pierre ULg

in Pferdeheilkunde (2002), 18(6), 569-573

Oxidative stress has become of increasing interest in research and human medicine. Oxidants or reactive oxygen species are generated by metabolic reactions and play an important role for the immune ... [more ▼]

Oxidative stress has become of increasing interest in research and human medicine. Oxidants or reactive oxygen species are generated by metabolic reactions and play an important role for the immune defence and the "redox-regulation" of gene expression, In physiological conditions, different categories of antioxidants maintain the equilibrium between the pro-oxidant burden and the endogenous antioxidant defence. However, when an imbalance between oxidants and antioxidants in favour of oxidants occurs, oxidative stress might induce irreversible lesions that can be evidenced and characterised by oxidant markers. In equine medicine, it has been shown that oxidative stress is occurring in lower airway disease and equine motor neuron disease. Moreover, adopted antioxicants therapy appears to have a beneficial effect on the antioxidant-oxidant imbalance. Exercise-induced oxidative stress and its impact on animal welfare and performance are also under investigation in equine sports medicine, Oxidative stress has been demonstrated to cepend on exercise type, intensity and duration. It might be modulated by training and/or adopted antioxidant therapy, aiming to maintain the antioxidant-oxidant equilibrium and thereby to improve animal welfare. [less ▲]

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See detailStudy of the structural, electronic, and magnetic properties of the barium-rich iron(IV) oxides, Ba2FeO4 and Ba3FeO5
Delattre, J. L.; Stacy, A. M.; Young, V. G. et al

in Inorganic Chemistry (2002), 41(11), 2834-2838

Crystals of Ba2FeO4 and Ba3FeO5, grown from a "self-sealing" KOH-Ba(OH)(2) flux, have been characterized by single-crystal X-ray diffraction, Mossbauer spectroscopy, and magnetic measurements. Ba2FeO4 ... [more ▼]

Crystals of Ba2FeO4 and Ba3FeO5, grown from a "self-sealing" KOH-Ba(OH)(2) flux, have been characterized by single-crystal X-ray diffraction, Mossbauer spectroscopy, and magnetic measurements. Ba2FeO4 forms nonmerohedral twinned crystals with the monoclinic space group P2(1)/c, a = 6.034(2) Angstrom, b = 7.647(2) Angstrom, c = 10.162(3) Angstrom, beta = 92.931(6)degrees, and Z = 4. Ba3FeO5 crystallizes in the orthorhombic space group Pnma, with a = 10.301(1) Angstrom, b = 8.151(1) Angstrom, c = 7.611(1) Angstrom, and Z = 4. While both compounds feature discrete FeO44- tetrahedra, the anion found in Ba2FeO4 has shorter Fe-O bonds and is significantly distorted relative to the Ba3FeO5 anion, An iron valence of 4+ was confirmed by magnet susceptibility measurements and by the low-temperature isomer shifts of -0.152 and -0.142 mm/s relative to alpha-iron for Ba2FeO4 and Ba3FeO5, respectively. [less ▲]

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See detailOn Sally Ledger and Roger Luckhurst’s The Fin de Siècle: A Reader in Cultural History c.1880-1900
Steyaert, Kris ULg

in Journal of Gender Studies (2002), 11(2), 192-193

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See detailRecurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability.
Paquet, Philippe ULg; Jacob, Eric; Damas, Pierre ULg et al

in Critical Care Medicine (2002), 30(11), 2580-3

OBJECTIVE: A series of antibiotics may be responsible for toxic epidermal necrolysis. We report two successive episodes of toxic epidermal necrolysis in the same patient. Drug imputability criteria ... [more ▼]

OBJECTIVE: A series of antibiotics may be responsible for toxic epidermal necrolysis. We report two successive episodes of toxic epidermal necrolysis in the same patient. Drug imputability criteria designate a cross-reactivity between two antibiotics of different chemical classes but sharing the beta-lactam ring in common. DESIGN: Descriptive case report and review of the literature. SETTING: Medical intensive care unit in a university medical center. PATIENT AND MAIN RESULTS: A 75-yr-old woman developed a first episode of toxic epidermal necrolysis (involving 40% of the body surface) after intake of cefotaxime, a third-generation cephalosporin. Perfusions of high-dose immunoglobulins rapidly improved the lesions, followed by partial reepithelialization in 5 days. Sepsis required the administration of meropenem, which is a carbapenem antibiotic. The epidermal destruction immediately recurred, with extension to previously uninvolved skin areas and fatal consequences. CONCLUSIONS: The beta-lactam ring present in cephalosporins and carbapenems represents the putative chemical structure responsible for the presently reported cross-reactivity to two antibiotics of different classes. Drugs having any chemical similarity to the initial culprit compound should be strictly avoided when possible in the management of toxic epidermal necrolysis. [less ▲]

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See detailVictimisation dans les petites et moyennes entreprises
Lemaître, André ULg

in Sécurité privée (2002), N°13

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See detailEtalonnage de l’épreuve grapho-perceptive de Bender sur une population d’enfants de six à dix ans
Garcet, Serge ULg; Deltour, Jean-Jacques

in Revue Scientifique de l'AIGS (2002), 1

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See detailLe métabolisme du fer
Beguin, Yves ULg

in Hématologie (2002), 8

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See detailThree-dimensional organization of active rRNA genes within the nucleolus.
Cheutin, Thierry; O'Donohue, Marie*-Francoise; Beorchia, Adrien et al

in Journal of Cell Science (2002), 115(Pt 16), 3297-307

In this work, we have localized transcribing rRNA genes at the ultrastructural level and described their three-dimensional organization within the nucleolus by electron tomography. Isolated nucleoli ... [more ▼]

In this work, we have localized transcribing rRNA genes at the ultrastructural level and described their three-dimensional organization within the nucleolus by electron tomography. Isolated nucleoli, which exhibit a reduced transcriptional rate, were used to determine the sites of initial BrUTP incorporation (i.e. rRNA synthesis by the transcriptional machinery). Using pulse-chase experiments with BrUTP and an elongation inhibitor, cordycepin, it was possible to precisely localize the initial sites of BrUTP incorporation. Our data show that BrUTP incorporation initially takes place in the fibrillar centers and that elongating rRNAs rapidly enter the surrounding dense fibrillar component. Furthermore, we investigated the spatial arrangement of RNA polymerase I molecules within the whole volume of the fibrillar centers. Electron tomography was performed on thick sections of cells that had been labeled with anti-RNA polymerase I antibodies prior to embedding. Detailed tomographic analyses revealed that RNA polymerase I molecules are mainly localized within discrete clusters. In each of them, RNA polymerase I molecules were grouped as several coils, 60 nm in diameter. Overall, these findings have allowed us to propose a model for the three-dimensional organization of transcribing rDNA genes within the nucleolus. [less ▲]

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See detailDifferential sensitivity of two insect GABA-gated chloride channels to dieldrin, fipronil and picrotoxinin
Le Corronch, Hervé; Alix, Philippe ULg; Hue, B

in Journal of Insect Physiology (2002), 48

In the central nervous system of both vertebrates and invertebrates inhibitory neurotransmission is mainly achieved through activation of gamma-aminobutyric acid (GABA) receptors. Extensive studies have ... [more ▼]

In the central nervous system of both vertebrates and invertebrates inhibitory neurotransmission is mainly achieved through activation of gamma-aminobutyric acid (GABA) receptors. Extensive studies have established the structural and pharmacological properties of vertebrate GABA receptors. Although the vast majority of insect GABA-sensitive responses share some properties with vertebrate GABAA receptors, peculiar pharmacological properties of these receptors led us to think that several GABA-gated chloride channels are present in insects. We describe here the pharmacological properties of two GABA receptor subtypes coupled to a chloride channel on dorsal unpaired median (DUM) neurones of the adult male cockroach. Long applications of GABA induce a large biphasic hyperpolarization, consisting of an initial transient hyperpolarization followed by a slow phase of hyperpolarization that is not quickly desensitized. With GABA, the transient hyperpolarization is sensitive to picrotoxinin, fipronil and dieldrin whereas the slow response is insensitive to these insecticides.When GABA is replaced by muscimol and cis-4-aminocrotonic acid (CACA) a biphasic hyperpolarization consisting of an initial transient hyperpolarization followed by a sustained phase is evoked which is blocked by picrotoxinin and fipronil. Exposure to dieldrin decreases only the early phase of the muscimol and CACA-induced biphasic response, suggesting that two GABA-gated chloride channel receptor subtypes are present in DUM neurones. This study describes, for the first time, a dieldrin resistant component different to the dieldrin- and picrotoxinin-resistant receptor found in several insect species. [less ▲]

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See detailComment je traite ... une polyarthrite rhumatoïde. L'avènement d'une nouvelle ère thérapeutique: les anticorps anti-TNF-alpha
Kaiser, Marie-Joëlle ULg; Malaise, Michel ULg

in Revue Médicale de Liège (2002), 57(8), 486-492

Rheumatoid arthritis (RA) is the most frequent autoimmune inflammatory arthropathy. Chronic synovial inflammation usually results in cartilage destruction, bone erosion and subsequent joint deformities ... [more ▼]

Rheumatoid arthritis (RA) is the most frequent autoimmune inflammatory arthropathy. Chronic synovial inflammation usually results in cartilage destruction, bone erosion and subsequent joint deformities with impaired physical function. These consequences are more or less delayed by standard disease-modifying antirheumatic drugs (DMARDs). A better knowledge of the basic mechanisms of the disease and new biomolecular tools led to the development of novel biological agents including TNF alpha blockers. TNF alpha is a key inflammatory cytokine that plays a critically important role in the pathogenesis of RA. TNF alpha blockers brought dramatic improvements in efficacy of RA treatment. Here we will review the pathophysiological elements of RA wich explain the therapeutic efficacy of these TNF alpha blockers and we will describe in details the molecules, Remicade (Infliximab) and Enbrel (Etanercept), wich will be very soon used in daily practice in Belgium. [less ▲]

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See detailA randomized comparison of the value of additional stenting after optimal balloon angioplasty for long coronary lesions: final results of the additional value of NIR stents for treatment of long coronary lesions (ADVANCE) study.
Serruys, Patrick W.; Foley, David P.; Suttorp, Martin Jan et al

in Journal of the American College of Cardiology (2002), 39(3), 393-9

OBJECTIVES: We sought to investigate the clinical benefit of additional stent implantation after achieving an optimal result of balloon angioplasty (BA) in long coronary lesions (>20 mm). BACKGROUND: Long ... [more ▼]

OBJECTIVES: We sought to investigate the clinical benefit of additional stent implantation after achieving an optimal result of balloon angioplasty (BA) in long coronary lesions (>20 mm). BACKGROUND: Long coronary lesions are associated with increased early complications and late restenosis after BA. Stenting improves the early outcome, but stent restenosis is also related to both lesion length and stent length. METHODS: A total of 437 patients with a single native lesion 20 to 50 mm in length were included and underwent BA, using long balloons matched to lesion length and vessel diameter (balloon/artery ratio 1.1) to achieve a diameter stenosis (DS) <30% by on-line quantitative coronary angiography (QCA). "Bail-out stenting" was performed for flow-limiting dissections or >50% DS. Patients in whom an optimal BA result was achieved were randomized to additional stenting (using NIR stents) or no stenting. The primary end point was freedom from major adverse cardiac events (MACE) at nine months, and core laboratory QCA was performed on serial angiograms. RESULTS: Bailout stenting was necessary in 149 patients (34%) and was associated with a significantly increased risk of peri-procedural infarction (p < 0.02). Among the 288 randomized patients, the mean lesion length was 27+/-9 mm, and the vessel diameter was 2.78+/-0.52 mm. The procedural success rate was 90% for the 143 patients assigned to BA alone (control group), as compared with 93% in the 145 patients assigned to additional stenting (stent group), which resulted in a superior early minimal lumen diameter (0.54 mm, p < 0.001) and led to reduced angiographic restenosis (27% vs. 42%, p = 0.022). Freedom from MACE at nine months was 77% in both groups. CONCLUSIONS: A strategy of provisional stenting for long coronary lesions led to bailout stenting in one-third of patients, with a threefold increase in peri-procedural infarction. Additional stenting yielded a lower angiographic restenosis rate, but no reduction in MACE at nine months. [less ▲]

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See detailEcology of Salmonella in slaughter pigs digestive tract and study of the contamination of carcasses
Boudry, Christelle ULg; Korsak Koulagenko, Nicolas ULg; Jacob, Benoit et al

in Annales de Médecine Vétérinaire (2002), 146(6, DEC-JAN), 353-360

This article presents a study on the Salmonella asymptomatic carriage of finishing pigs and its consequences on the contamination of carcasses. Twenty finishing pigs were followed to determine the faecal ... [more ▼]

This article presents a study on the Salmonella asymptomatic carriage of finishing pigs and its consequences on the contamination of carcasses. Twenty finishing pigs were followed to determine the faecal shedding of Salmonella. No sample was positive but at the slaughterhouse, the analysis of tonsils and certain parts of the digestive tract (mesenterial lymph nodes, ileum and large intestine content) revealed that 70% of the pigs were positive. The strains isolated from the faecal samples of the large intestine and from tonsils were identical, which might indicate that there has been an oral contamination from pig to pig due to the shedding of Salmonella or a carriage of different strains in different organs. The mesenterial lymph nodes (40 % positive) were contaminated by strains which were different from those from the faecal samples and tonsils. Salmonella strains were only found on the swabs of one carcass. A complementary assay has shown the negative role played by the scalding step. This latter may contaminate the oral and rectal cavities of slaughtered animals. This entire study reveals the difficulty to predict the contamination risk at the slaughterhouse from the analysis of finishing pigs faecal samples. Therefore, a better knowledge of the carriage and the shedding of Salmonella during the finishing period and during the slaughter is necessary to minimise meat contamination. [less ▲]

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See detailFédéralisme et extrême droite au Royaume-Uni
Jamin, Jérôme ULg

in Fédéralisme - Régionalisme (2002), 2

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See detailGlobal democratic consensus on neuropathological disease criteria.
Achim, Cristian; Auer, Roland; Bergeron, Catherine et al

in Lancet Neurology (2002), 1(6), 340

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See detailL'exclusion de la réassurance des règles européennes de conflits de juridictions en matière de contrats d'assurance
Boularbah, Hakim ULg

in Bulletin des Assurances = Tijdschrift voor Verzekeringen (2002)

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See detailIn situ dynamic analysis of solid or aqueous solutions undergoing chemical reactions by RBS or PIXE with external beam
Bouquillon, A.; Dran, J*-C; Lagarde, G. et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2002), 188

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See detailAllergic reactions to decorative skin paintings
Nikkels, Arjen ULg; Henry, Frédérique ULg; Pierard, Gérald ULg

in Allergy Review series (2002), 3

Three children presented with contact sensitization to decorative skin paintings applied during their summer holidays. Patch testing revealed severe contact hypersensitivity to p-phenylenediamine (PPD) in ... [more ▼]

Three children presented with contact sensitization to decorative skin paintings applied during their summer holidays. Patch testing revealed severe contact hypersensitivity to p-phenylenediamine (PPD) in all patients. The eruptions healed following spontaneous elimination of the dyes and application of topical corticosteroids, but left postinflammatory depigmentation. PPD was the main allergen identified in allergic reactions to decorative skin paintings. [less ▲]

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See detailUse of a serum-free medium to produce in vitro Neospora caninum and Toxoplasma gondii tachyzoites on Vero cells
De Meerschman, F.; Rettigner, C.; Focant, Charles ULg et al

in Veterinary Research (2002), 33(2, Mar-Apr), 159-168

Neospora caninum and Toxoplasma gondii are cyst-forming coccidian parasites of human and veterinary clinical relevance. In vitro cultivation of the protozoans using Vero cells is usually performed in ... [more ▼]

Neospora caninum and Toxoplasma gondii are cyst-forming coccidian parasites of human and veterinary clinical relevance. In vitro cultivation of the protozoans using Vero cells is usually performed in order to produce antigenic materials. Quantitative and qualitative comparisons of Vero cells grown in RPMI medium supplemented either with foetal calf serum (FCS), horse serum (HS) or a specific serum-free additive (DefCell) were performed. A serum-free cell culture system used to propagate N. caninum (NC-1 isolate) and T. gondii tachyzoites (Rh stain) were compared with the other two cell culture systems. FCS supplemented media was found to be more effective than the others in promoting Vero cells and N. caninum tachyzoites. However, it was found unable to support adequate T. gondii tachyzoite proliferation. Vero cells, T. gondii and N. caninum tachyzoite production gave similar growth patterns with either HS or DefCell supplemented media. Defcell was considered as a good alternative to supplement culture medium. [less ▲]

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See detailErratum to: “Perturbative evolution and Regge behaviour”: [Phys. Lett. B 448 (1999) 281]
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P.

in Physics Letters B (2002), 528

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See detailLe traitement de la phraséologie dans DEFI
Michiels, Archibal ULg

in Linguistica Antverpiensia (2002)

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See detailLes contes de Grimm: présentation de quelques inconnus en français qui témoignent de l'entrée des Contes de l'Enfance et du Foyer dans la littérature de jeunesse
Delbrassine, Daniel ULg

in Cahiers du CLPCF (2002), 2

Présentation et traduction de contes retranchés dans le recueil des Grimm

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See detailEchouage de mammifères marins : guide d'intervention et procédures d'autopsie
Jauniaux, Thierry ULg; Garcia-Hartmann, M.; Haelters, J. et al

in Annales de Médecine Vétérinaire (2002), 146(5, OCT-NOV), 261-276

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See detailRegulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.
Michiels, Carine; Minet, Emmanuel; Mottet, Denis ULg et al

in Free Radical Biology & Medicine (2002), 33(9), 1231-42

Aerobic life is dependent on molecular oxygen for ATP regeneration, but only possible in a narrow range of oxygen concentrations. Increased oxygen tension is toxic through the generation of reactive ... [more ▼]

Aerobic life is dependent on molecular oxygen for ATP regeneration, but only possible in a narrow range of oxygen concentrations. Increased oxygen tension is toxic through the generation of reactive oxygen species (ROS), while a decrease in oxygen concentration impairs energy availability and, hence, cell viability. Cells have developed strategies to respond to changes in oxygen tension: specific systems detect excessive ROS and hypoxia, leading to the activation of specific transcription factors and expression of appropriate target genes. The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels. Some of the physiological responses initiated by these transcription factors are also mentioned. [less ▲]

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See detailEffects of incidental and intentional feature binding on recognition: a behavioural and PET activation study
Lekeu, Françoise ULg; Van der Linden, Martial ULg; Collette, Fabienne ULg et al

in Neuropsychologia (2002), 40(2), 131-144

Using Positron Emission Tomography (PET), we investigated cerebral regions associated with the episodic recognition of words alone and words bound to contextual colours. Two modes of colour encoding were ... [more ▼]

Using Positron Emission Tomography (PET), we investigated cerebral regions associated with the episodic recognition of words alone and words bound to contextual colours. Two modes of colour encoding were tested: incidental and intentional word-to-colour binding. Word-only recognition was associated with brain activation in a lexico-semantic left middle temporal region and in the cerebellum following an incidental colour encoding, and with brain activation in the left posterior middle frontal gyrus, right anterior cingulate and right inferior frontal gyrus following an intentional encoding. Recognition of bound features was associated with activation in left prefrontal and superior parietal regions following an incidental colour encoding, and with preferential right prefrontal cortex activation following an intentional colour encoding. Our results are in line with the hypothesis of a parietal involvement in context processing, and prefrontal areas in monitoring retrieval processes. Our results also support the hypothesis of a 'cortical asymmetry for reflective activity' (CARA). [less ▲]

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See detailActive insulation in dwellings
Embrechts, Jean-Jacques ULg; Caule, Patrice; Tamaz, Patrick et al

in NAG journaal (2002), 162

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See detailThe flowering process: On the track of controlling factors in Sinapis alba
Bernier, Georges ULg; Corbesier, Laurent; Périlleux, Claire ULg

in Russian Journal of Plant Physiology (2002), 49(4, JUL-AUG), 445-450

The major physiological theories of the control of the flowering process are first presented and their inferences tested in the long-day plant Sinapis alba. Then, the genetic analyses of the control of ... [more ▼]

The major physiological theories of the control of the flowering process are first presented and their inferences tested in the long-day plant Sinapis alba. Then, the genetic analyses of the control of flowering time in Arabidopsis thaliana are also summarized with a brief overview of the several pathways, each including several genes, identified. Clearly, both the experimental data of physiological experiments and the multiplicity of interacting genetic pathways best support the theory of the multifactorial control of flowering. This is further shown by the fact that a critical gene expressed in the shoot meristem at floral transition in S. alba, MADS A (orthologous to A. thaliana SOC1), can be upregulated by a single dose of a cytokinin or a gibberellin, without leading to flowering. This indicates that the floral shift requires upregulation of other genes by other factors. [less ▲]

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See detailPerformance de Acacia Auriculiformis (Cunn. A.) dans le système agroforestier au Sud-Bénin
Fonton, H. N.; Claustriaux, Jean-Jacques ULg; Agbahungba, G.

in Annales des Sciences Agronomiques du Bénin (2002), 3(1), 65-79

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See detailAutomatic time stepping algorithms for implicit numerical simulations of non-linear dynamics
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Advances in Engineering Software (2002), 33(7-10, JUL-OCT), 589-603

When an implicit integration scheme is used, variable step strategies are especially well suited to deal with problems characterized by high non-linearities. Constant step size strategies generally lead ... [more ▼]

When an implicit integration scheme is used, variable step strategies are especially well suited to deal with problems characterized by high non-linearities. Constant step size strategies generally lead to divergence or extremely costly computations. An automatic time stepping algorithm is proposed that is based on estimators of the integration error of the differential dynamic balance equations. Additionally, the proposed algorithm automatically takes decisions regarding the necessity of updating the tangent matrix or stopping the iterations, further reducing the computational cost. As an illustration of the capabilities of this algorithm, several numerical simulations of both academic and industrial problems are presented. (C) 2002 Civil-Comp Ltd and Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailFatty Acid Hydroperoxides Biotransformation By Potato Tuber Cell-Free Extracts
Fauconnier, Marie-Laure ULg; Delcarte, J.; Jaziri, M. et al

in Journal of Plant Physiology (2002), 159(10),

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See detailCoalescence of secondary dispersions in fiber beds
Speth, Hauke; Pfennig, Andreas ULg; Chatterjee, Michael et al

in Separation and Purification Technology (2002), 29(2), 113-119

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See detailApproche diagnostique d'une élévation des transaminases
Delwaide, Jean ULg; Delfosse, V.; Detry, Olivier ULg

in Patient Care (2002), 18(2), 10-16

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See detailLes débuts du paléolithique supérieur dans le nord-ouest de l’Europe : le Lincombien-Ranisien-Jerzmanowicien (état de la question)
Flas, Damien ULg

in Anthropologica et Praehistorica : Bulletin de la Société Royale Belge d'Anthropologie et de Préhistoire (2002), 113

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See detailWalloon Region: An agro-forestry landscape without farmers?
Schmitz, Serge ULg

in Dela (2002), 17

Great landscape diversity of Walloon region, actions for a rural renewal, migratory flows back to rural areas and new challenges of Wallon rural area are presented

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See detailAnxiety and hyperventilation in mild to moderate asthmatics
Delvaux, Muriel ULg; Fontaine, Ovide ULg; Bartsch, Pierre ULg

in European Review of Applied Psychology = Revue Européenne de Psychologie Appliquée (2002), 52(2), 149-160

Studied breathing patterns and hyperventilation symptoms in 80 adolescents and adults (aged 16-60 yrs) with mild to moderate asthma and 40 adolescents and adults (aged 16-60 yrs) with no asthma symptoms ... [more ▼]

Studied breathing patterns and hyperventilation symptoms in 80 adolescents and adults (aged 16-60 yrs) with mild to moderate asthma and 40 adolescents and adults (aged 16-60 yrs) with no asthma symptoms (healthy controls). Data on pulmonary function, ventilation and breathing pattern, and psychological symptoms were obtained by clinical observation and questionnaire. Asthmatic Ss were requested not to take bronchodilatation medications for 24-48 hrs prior to testing. The Anxiety Sensitivity Index-Revised (S. Taylor and Cox, 1998), the Self-Consciousness Scale-Revised (A. Fenigwstein et al, 1975), the State-Train Anxiety Inventory, the Nijmegen Questionnaire (P. van Doorn et al, 1982), the Sense of Coherence Scale (A. Antonovsky, 1987), the Positive and Negative Affect Schedule (D. Watson et al, 1988), the Beck Depression Inventory, and the Asthma Symptoms Checklist (R. A. Kinsman et al, 1973, revision by Brooks et al, 1989) were used. The results show that the asthmatic subjects have lower PetCO2 than normal subjects and that variables associated with lower PetCO2 include total volume, female gender, and negative affectivity. The results also show that female subjects and asthmatics have similar breathing patterns and compared to male subjects [less ▲]

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See detailDiscovery of soft X-ray emission from Io, Europa, and the Io Plasma Torus
Elsner, Ronald F.; Gladstone, G. Randall; Waite, J. Hunter et al

in Astrophysical Journal (2002), 572(2), 1077-1082

We report the discovery of soft (0.25-2 keV) X-ray emission from the Galilean satellites Io and Europa, probably Ganymede, and from the Io Plasma Torus (IPT). Bombardment by energetic (greater than 10 keV ... [more ▼]

We report the discovery of soft (0.25-2 keV) X-ray emission from the Galilean satellites Io and Europa, probably Ganymede, and from the Io Plasma Torus (IPT). Bombardment by energetic (greater than 10 keV) H, O, and S ions from the region of the IPT seems to be the likely source of the X-ray emission from the Galilean satellites. According to our estimates, fluorescent X-ray emission excited by solar X-rays, even during flares from the active Sun, charge-exchange processes, previously invoked to explain Jupiter's X-ray aurora and cometary X-ray emission, and ion stripping by dust grains fail to account for the observed emission. On the other hand, bremsstrahlung emission of soft X-rays from nonthermal electrons in the few hundred to few thousand eV range may account for a substantial fraction of the observed X-ray flux from the IPT. [less ▲]

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See detailLeukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression.
Baron, Frédéric ULg; Turhan, Ali G; Giron-Michel, Julien et al

in Blood (2002), 99(6), 2107-13

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces ... [more ▼]

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces growth factor independence. However, the influence of BCR-ABL expression on cell-mediated cytotoxicity is poorly understood. In the present study, we asked whether BCR-ABL expression interferes with leukemic target sensitivity to natural killer (NK) cell cytolysis. Our approach was based on the use of 2 BCR-ABL transfectants of the pluripotent hematopoietic cell line UT-7 expressing low (UT-7/E8, UT-7/G6) and high (UT-7/9) levels of BCR-ABL. As effector cells, we used CD56(bright), CD16-, CD2- NK cells differentiated in vitro from CD34 cord blood progenitors. We demonstrated that BCR-ABL transfectants UT-7/9 were lysed by NK cells with a higher efficiency than parental and low UT-7/E8.1 and UT-7/G6 transfectants. This enhanced susceptibility to lysis correlated with an increase in expression of intercellular adhesion molecule 1 (ICAM-1) by target cells. Treatment of UT-7/9 cells by STI571 (a specific inhibitor of the abl kinase) resulted in a decrease in NK susceptibility to lysis and ICAM-1 down-regulation in target cells. Furthermore, the constitutive activation of nuclear factor-kappaB (NF-kappaB) detected in BCR-ABL transfectant UT-7/9, was significantly attenuated when cells were treated by STI571. Interestingly, inhibition of NF-kappaB activation by BAY11-67082 (a specific NF-kappaB inhibitor) resulted in down-regulation of ICAM-1 expression and a subsequent decrease in NK-induced killing of UT-7/9 transfectants. Our results show that oncogenic transformation by BCR-ABL may increase susceptibility of leukemic progenitors to NK cell cytotoxicity by a mechanism involving overexpression of ICAM-1 as a consequence of NF-kappaB activation. [less ▲]

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See detailL'image du mois. Une tumeur du cuir chevelu révélatrice d'une naevomatose basocellulaire.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(4), 185-6

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See detailLe parquet fédéral est arrivé : plus-value pour le ministère public ?
Masset, Adrien ULg

in Journal des Tribunaux (2002), 6043(2002), 121-129

La loi du 21 juin 2001 modifiant certaines dispositions en ce qui concerne le parquet fédéral rend celui-ci effectif à partir du 21 mai 2002. Cette nouvelle institution au sein du ministère public a ... [more ▼]

La loi du 21 juin 2001 modifiant certaines dispositions en ce qui concerne le parquet fédéral rend celui-ci effectif à partir du 21 mai 2002. Cette nouvelle institution au sein du ministère public a suscité de vives critiques de la part du Conseil d’Etat, du collège des procureurs généraux, du conseil des procureurs du Roi et du Conseil supérieur de la justice. Est spécialement critiquée l’imprécision avec laquelle le procureur fédéral et les magistrats fédéraux pourront exercer l’action publique dans une série de dossiers aux contours incertains, en lieu et place des procureurs du Roi locaux; les risques de conflits et de ponctions systématiques dans les forces vives des parquets locaux inquiètent, de même que l’indépendance du procureur fédéral. [less ▲]

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See detailNonmyeloablative stem cell transplantation with CD8-depleted or CD34-selected peripheral blood stem cells.
Baron, Frédéric ULg; Baudoux, Etienne ULg; Frere, Pascale ULg et al

in Journal of Hematotherapy & Stem Cell Research (2002), 11(2), 301-14

To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed ... [more ▼]

To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed by CD8-depleted preemptive donor lymphocyte infusion (DLI) given in incremental doses on days 40 and 80. Fourteen patients with high-risk malignancies and an HLA-identical sibling (n = 8) or alternative donor (n = 6) but ineligible for a conventional transplant were included. Nonmyeloablative conditioning regimen consisted in 2 Gy total body irradiation (TBI) alone, 2 Gy TBI and fludarabine (previously untreated patients) or cyclophosphamide and fludarabine (patients who had previously received > or =12 Gy TBI). Patients 1-4 (controls) received unmanipulated peripheral blood stem cells (PBSC) and DLI and patients 5-14 CD8-depleted or CD34-selected PBSC followed by CD8-depleted DLI. Post-transplant immunosuppression was carried out with cyclosporine A (CsA) and mycophenolate mofetil (MMF). Initial engraftment was seen in all patients, but 1 patient (7%) later rejected her graft. The actuarial 180-day incidence of grades II-IV acute GVHD was 75% for patients 1-4 versus 0% for patients 5-14 (p = 0.0019). Five of 14 patients were in complete remission (CR) 180 days after the transplant and 6/14 had partial responses. The 1-year survival rate was 69%, and nonrelapse and relapse mortality rates were 16 and 18%, respectively. We conclude that CD8-depleted or CD34-selected NMSCT followed by CD8-depleted DLI is feasible and considerably decreases the incidence of acute GVHD while preserving engraftment and apparently also the graft-versus-leukemia (GVL) effect. Further studies are needed to confirm this encouraging preliminary report. [less ▲]

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See detailInfluence Of A New Axial Impeller On K(L)A And Xylanase Production By Penicillium Canescens 10-10c
Bakri, Yasser; Jacques, Philippe ULg; Shi, Kui et al

in Applied Biochemistry and Biotechnology (2002), 98

The effects of a new axial impeller (HTPG4) on oxygen volumetric transfer coefficient, KLa, and xylanase production by Penicillium canescens 10-10c were studied and compared for dual-impeller systems, one ... [more ▼]

The effects of a new axial impeller (HTPG4) on oxygen volumetric transfer coefficient, KLa, and xylanase production by Penicillium canescens 10-10c were studied and compared for dual-impeller systems, one with one DT4 impeller below and one HTPG4 above (DT4-HTPG4) and one with two DT4 (DT4-DT4) impellers, in a 5-L bioreactor. The volumetric coefficient of oxygen transfer was measured in culture medium using a gassing-out method at different gassing rates and agitation speeds. We observed that the DT4-HTPG4 combination provided better KLa performance than the DT4-DT4 combination. The two combinations were also tested for their influence on xylanase production by a filamentous microorganism; P. canescens 10-10c. These experiments demonstrated that the DT4-HTPG4 combination impeller enhanced enzyme production up to 23% compared with the DT4-DT4 combination at an aeration rate of 1 vvm and an agitation speed of 600 rpm. The main cause for this difference is thought to be a higher shear stress generated by the DT4-DT4 combination, which damages the mycelium of P. canescens and decreases xylanase production. [less ▲]

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See detailTreatment of mucocutaneous presentations of herpes simplex virus infections.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2002), 3(7), 475-87

Infections by herpes simplex virus (HSV) types I and II are diverse and quite frequent. After primary infection, the virus establishes a life-long latency in the sensory ganglia and recrudescences may ... [more ▼]

Infections by herpes simplex virus (HSV) types I and II are diverse and quite frequent. After primary infection, the virus establishes a life-long latency in the sensory ganglia and recrudescences may occur at an unpredictable rate. Recurrent labial and genital herpes infections represent the majority of clinical manifestations of HSV infections. Their management is currently well established using evidence-based medicine data. Primary labial herpes is generally not treated with antivirals in otherwise healthy children, although intravenous aciclovir may be offered in severe primary infections, particularly in the immunocompromised patient. The decision whether or not to treat recurrent labial herpes should be evaluated individually and depends on the frequency and severity of relapses, the impairment of the quality of life, and the cost of therapy. Patients with mild disease may benefit from topical therapy, and those with severe and frequent recurrences may be considered for intermittent or long-term oral antiviral therapy. Primary genital herpes is treated with oral or intravenous antivirals, depending on the severity of the infection and associated symptoms. Recurrent genital herpes can be managed with episodic short courses of oral antivirals in patients whose recurrences are moderate to severe and rare, and have a clear prodrome. Patients with >5 episodes/year, severe recurrences or unrecognisable prodromes may be best managed with long-term suppressive antiviral prophylaxis. HSV is also responsible for a variety of other clinical manifestations, including herpetic whitlow, neonatal infection, disseminated and atypical cutaneous infections, traumatic herpes, eczema herpeticum, and HSV-associated erythema multiforme. HSV infection may also represent a complication following cosmetic procedures of the oro-facial region, surgical and dental interventions, sun exposure and burns. Precise treatment guidelines for these HSV infections are not firmly established. [less ▲]

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See detailClassical and Bayesian inference in neuroimaging: Applications
Friston, Karl J; Glaser, Daniel E; Henson, Richard NA et al

in Neuroimage (2002), 16(2), 484-512

In Friston et al. ((2002) Neuroimage 16: 465-483) we introduced empirical Bayes as a potentially useful way to estimate and make inferences about effects in hierarchical models. In this paper we present a ... [more ▼]

In Friston et al. ((2002) Neuroimage 16: 465-483) we introduced empirical Bayes as a potentially useful way to estimate and make inferences about effects in hierarchical models. In this paper we present a series of models that exemplify the diversity of problems that can be addressed within this framework. In hierarchical linear observation models, both classical and empirical Bayesian approaches can be framed in terms of covariance component estimation (e.g., variance partitioning). To illustrate the use of the expectation-maximization (EM) algorithm in covariance component estimation we focus first on two important problems in fMRI: nonsphericity induced by (i) serial or temporal correlations among errors and (ii) variance components caused by the hierarchical nature of multisubject studies. In hierarchical observation models, variance components at higher levels can be used as constraints on the parameter estimates of lower levels. This enables the use of parametric empirical Bayesian (PEB) estimators, as distinct from classical maximum likelihood (ML) estimates. We develop this distinction to address: (i) The difference between response estimates based on ML and the conditional means from a Bayesian approach and the implications for estimates of intersubject variability. (ii) The relationship between fixed- and random-effect analyses. (iii) The specificity and sensitivity of Bayesian inference and, finally, (iv) the relative importance of the number of scans and subjects. The forgoing is concerned with within- and between-subject variability in multisubject hierarchical fMRI studies. In the second half of this paper we turn to Bayesian inference at the first (within-voxel) level, using PET data to show how priors can be derived from the (between-voxel) distribution of activations over the brain. This application uses exactly the same ideas and formalism but, in this instance, the second level is provided by observations over voxels as opposed to subjects. The ensuing posterior probability maps (PPMs) have enhanced anatomical precision and greater face validity, in relation to underlying anatomy. Furthermore, in comparison to conventional SPMs they are not confounded by the multiple comparison problem that, in a classical context, dictates high thresholds and low sensitivity. We conclude with some general comments on Bayesian approaches to image analysis and on some unresolved issues. [less ▲]

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