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See detailEmile Adan en de introductie van reisinstructies voor de Belgische wetenschappelijke exploratie in Midden-Afrika.
Vandersmissen, Jan ULg

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in Belgie (2003), 74(1-4), 205-217

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See detailIsolation and partial characterization of three pregnancy-associated glycoproteins from the ewe placenta
El Amiri, B.; Remy, Benoit; Melo de Sousa, Noelita ULg et al

in Molecular Reproduction and Development (2003), 64(2), 199-206

Pregnancy-associated glycoproteins (PAGs) are synthesized in the outer epithelial layer of the placenta in artiodactyls. In this work, three novel ovine PAGs were isolated from late-pregnancy fetal ... [more ▼]

Pregnancy-associated glycoproteins (PAGs) are synthesized in the outer epithelial layer of the placenta in artiodactyls. In this work, three novel ovine PAGs were isolated from late-pregnancy fetal cotyledons and characterized biochemically. The isolation procedure included acid and ammonium sulfate precipitations and anion and cation exchange chromatographies. The isolated PAGs have different NH2-terminal amino acid sequences (RGSXLTILPLRNMRDIVY, ISRVSXLTIHPLRNIMDML, and RGSNLTIHPLRNIRD) and apparent molecular masses (55, 57, and 59 kDa). Each shows several isoforms with different pl values. The three proteins share high sequence identity with each other and with other ovine, bovine, and caprine PAGs. They have not been described previously. The ovPAG-59 sequence differs from the previously identified ovPAG-4 sequence (determined by DNA cloning and sequencing) at only one position among the 15 N-terminal residues. The newly characterized ovPAGs and the procedure used to isolate them will be helpful in producing new antisera for investigating PAG secretion in pregnant ewes. [less ▲]

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See detailEnfin "Tubambe" devoile son identite! Hadraphe ethiopica (Bethune-Baker) (Limacodidae), une chenille comestible des forets claires zambeziennes.
Malaisse, François ULg; Demesmaecker, Anne; Matera, Joseph et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(2), 67-77

La consommation humaine de chenilles de Limacodidae avait été signalée en Afrique centro-australe. L’une de ces espèces, Hadraphe ethiopica, a été déterminée. Des données relatives à sa biologie ont été ... [more ▼]

La consommation humaine de chenilles de Limacodidae avait été signalée en Afrique centro-australe. L’une de ces espèces, Hadraphe ethiopica, a été déterminée. Des données relatives à sa biologie ont été rassemblées. Des analyses d’échantillons séchés ont permis de préciser leur composition chimique et leur valeur nutritionnelle, notamment sur le plan des acides aminés et des acides gras. [less ▲]

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See detailL'euthanasie en Belgique et aux Pays-Bas
Leleu, Yves-Henri ULg

in Revue Trimestrielle des Droits de l'Homme (2003)

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See detailLack of trans-activation function for Maedi Visna virus and Caprine arthritis encephalitis virus Tat proteins
Villet, S.; Faure, C.; Bouzar, Amel ULg et al

in Virology (2003)

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See detailThe Sturtian 'snowball' glaciation: fire and ice
Godderis, Y.; Donnadieu, Y.; Nedelec, A. et al

in Earth And Planetary Science Letters (2003), 211(1-2), 1-12

The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset ... [more ▼]

The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset of large basaltic provinces between 825 and 755 Ma. Among these magmatic events, the most important one is the onset of a Laurentian magmatic province at 780 Ma around a latitude of 30degreesN. The presence of these fresh basaltic provinces increases the weatherability of the continental surfaces, resulting in an enhanced consumption of atmospheric CO2 through weathering, inducing a global long-term climatic cooling. Based on recent weathering laws for basaltic lithology and on climatic model results, we show that the weathering of a 6 x 10(6) km(2) basaltic province located within the equatorial region (where weathering of the province and consumption of CO2 are boosted by optimal climatic conditions) is sufficient to trigger a snowball glaciation, assuming a pre-perturbation PCO2 value of 280 ppmv. We show that the Laurentian magmatic province might be the main culprit for the initiation of the Sturtian 'snowball' glaciation, since the Laurentian magmatic province had drifted within the equatorial region by the time of the glaciation. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailA taxonomic reassessment of the Vittiaceae (Hypnales, Bryopsida):evidence from phylogenetic analyses of combined chloroplast and nuclear sequence data
Vanderpoorten, Alain ULg; Goffinet, B.; Hedenäs, L. et al

in Plant Systematics & Evolution (2003), 241

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See detailRecognizing and interpreting the fossils of early eukaryotes
Javaux, Emmanuelle ULg; Knoll, A. H.; Walter, M.

in Origins of Life & Evolution of the Biosphere (2003), 33(1), 75-94

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context ... [more ▼]

Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context of early eukaryotic diversification. For this reason, recognition of eukaryotic fossils in Proterozoic rocks is key to the integration of geological and comparative biological perspectives on protistan evolution. Microfossils preserved in shales of the ca. 1500 Ma Roper Group, northern Australia, display characters that ally them to the Eucarya, but, at present, attribution to any particular protistan clade is uncertain. Continuing research on wall ultrastructure and microchemistry promises new insights into the nature and systematic relationships of early eukaryotic fossils. [less ▲]

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See detailLe passé récent, la réforme de l'impôt des personnes physiques, le cas des villes
Jurion, Bernard ULg

in Bulletin de Documentation du Ministère des Finances (2003)

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See detailRivers, chemical weathering and Earth's climate
Dupre, B.; Dessert, C.; Oliva, P. et al

in Comptes Rendus Geoscience (2003), 335(16), 1141-1160

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at ... [more ▼]

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at establishing chemical weathering laws for these two lithologies, describing the dependence of chemical weathering on environmental parameters, such as climate and mechanical erosion. As shown within this contribution, such mathematical laws are of primary importance for numerical models calculating the evolution of the partial pressure of atmospheric CO2 and the Earth climate at geological timescales. The major results can be summarized as follow: (1) weathering of continental basaltic lithologies accounts for about 30% of the total consumption of atmospheric CO2 through weathering of continental silicate rocks. This is related to their high weatherability (about eight times greater than the granite weatherability); (2) a simple weathering law has been established for basaltic lithologies, giving the consumption of atmospheric CO2 as a function of regional continental runoff, and mean annual regional temperature; (3) no such simple weathering law can be proposed for granitic lithologies, since the effect of temperature can only be identified for regions displaying high continental runoff; (4) a general law relating mechanical erosion and chemical weathering has been validated on small and large catchments. The consequences of these major advances on the climatic evolution of the Earth are discussed. Particularly, the impacts of the onset of the Deccan trapps and the Himalayan orogeny on the global carbon cycle are reinvestigated. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved. [less ▲]

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation.
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailFirst-principles calculation of the electronic, dielectric, and dynamical properties of CaF2
Verstraete, Matthieu ULg; Gonze, Xavier

in Physical Review. B : Condensed Matter (2003), 68

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See detailNonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases.
Heltweg, Birgit; Dequiedt, Franck ULg; Verdin, Eric et al

in Analytical Biochemistry (2003), 319(1), 42-8

Histone deacetylases (HDACs) are involved in the regulation of transcription and their inhibitors are a promising class of new anticancer drugs. We have previously reported Boc(Ac)Lys-AMC, also termed MAL ... [more ▼]

Histone deacetylases (HDACs) are involved in the regulation of transcription and their inhibitors are a promising class of new anticancer drugs. We have previously reported Boc(Ac)Lys-AMC, also termed MAL, as a fluorescent substrate for HDACs. Now we present a modification of MAL called Z-MAL that is characterized by an increased rate of conversion by histone deacetylases of classes I and II and the recently discovered sirtuins (histone deacetylases class III). MAL and Z-MAL are the first nonradioactive substrates for class III enzymes. The new substrate Z-MAL allows for shorter assay times in inhibitor screening and is applicable to diverse sources of deacetylase activity even with completely different catalytic mechanisms. Interestingly, MAL shows some relative preference toward class II, indicating that subtype selectivity in small-molecule HDAC substrates might be obtained. [less ▲]

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See detailBrain correlates of performance in a free/cued recall task with semantic encoding in Alzheimer disease
Lekeu, Françoise ULg; Van der Linden, Martial ULg; Chicherio, C. et al

in Alzheimer Disease and Associated Disorders (2003), 17(1), 35-45

The goal of this study was to explore in patients with Alzheimer's disease (AD) the brain correlates of free and cued recall performance using an adaptation of the procedure developed by Grober and ... [more ▼]

The goal of this study was to explore in patients with Alzheimer's disease (AD) the brain correlates of free and cued recall performance using an adaptation of the procedure developed by Grober and Buschke (1987). This procedure, which ensures semantic processing and coordinates encoding and retrieval, has been shown to be very sensitive to an early diagnosis of AD. Statistical parametric mapping (SPM 99) was used to establish clinicometabolic correlations between performance at free and cued verbal recall and resting brain metabolism in 31 patients with AD. Results showed that patient's score on free recall correlated with metabolic activity in right frontal regions (BA 10 and BA 45), suggesting that performance reflected a strategic retrieval attempt. Poor retrieval performance was tentatively attributed to a loss of functional correlation between frontal and medial temporal regions in patients with AD compared with elderly controls. Performance on cued recall was correlated to residual metabolic activity in bilateral parahippocampal regions (BA 36), suggesting that performance reflected retrieval of semantic associations, without recollection in AD. In conclusion, this study demonstrates that the diagnostic sensitivity for Alzheimer's disease of the cued recall performance in the Grober and Buschke procedure (1987) depends on the activity of parahippocampal regions, one of the earliest targets of the disease. Moreover, the results suggest that the poor performance of patients with AD during free and cued recall is related to a decreased connectivity between parahippocampal regions and frontal areas. [less ▲]

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See detailPrevalence and identity of cdt-related sequences in necrotoxigenic Escherichia coli
Mainil, Jacques ULg; Jacquemin, E.; Oswald, E.

in Veterinary Microbiology (2003), 94

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See detailSurfactant-assisted synthesis of unprecedented hierarchical meso-macrostructured zirconia
Yuan, Z.-Y.; Vantomme, A.; Léonard, Alexandre ULg et al

in Chemical Communications (2003), 9(13), 1558-1559

A surfactant-assisted one-step synthesis route was developed, leading to the formation of a very high surface area (600 m 2 g -1) of zirconia and unprecedented hierarchical meso-macroporous structure with ... [more ▼]

A surfactant-assisted one-step synthesis route was developed, leading to the formation of a very high surface area (600 m 2 g -1) of zirconia and unprecedented hierarchical meso-macroporous structure with wormhole-like mesoporous walls and a novel, uniform assembly of macropores ranging in size from 300 to 500 nm. [less ▲]

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See detailXylanase Production By Penicillium Canescens 10-10c In Solid-State Fermentation
Bakri, Y.; Jacques, Philippe ULg; Thonart, Philippe ULg

in Applied Biochemistry and Biotechnology (2003), 105

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See detailHemiurothorax following diaphragmatic hernia and kidney prolapse in a cat.
Stork, Christoph; Hamaide, Annick ULg; Schwedes, Claudia et al

in Journal of Feline Medicine and Surgery (2003), 5(2), 91-96

A 3-year-old cat was presented with increasing dyspnoea over the past four days. Unilateral pleural effusion was diagnosed and a modified transudate was drained several times. Surgical exploration ... [more ▼]

A 3-year-old cat was presented with increasing dyspnoea over the past four days. Unilateral pleural effusion was diagnosed and a modified transudate was drained several times. Surgical exploration revealed intra-thoracic prolapse of the left kidney and partial herniation of the spleen through a dorsal, circumferential diaphragmatic tear. Biochemical analysis of the pleural fluid confirmed urothorax. Due to excessive fibrin deposit on the well-vascularised kidney it was impossible to re-establish left urinary pathways. Left-sided nephrectomy and diaphragmatic herniorrhaphy were performed. Postoperative recovery was uneventful and complete. This is the first report of an urothorax in veterinary medical literature. (C) 2002 ESFM and AAFP. Published by Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailGrown So Ugly : Frank Zappa’s Poetics of Orality
Delville, Michel ULg

in Prague Literary Review (2003), 2

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See detailBiomarqueurs de toxicité et anomalies métaboliques dans les principales intoxications graves. Symptomatologie clinique et toxique. Le prélèvement conservatoire.
Goullé, Jean-Pierre; Lhermitte, Michel; Bartholi, M. et al

in Annales de Biologie Clinique (2003), 61(4), 421-433

Les membres du groupe de travail pluridisciplinaire « Toxicologie et biologie clinique » appartenant à la Société française de biologie clinique (SFBC), à la Société française de toxicologie analytique ... [more ▼]

Les membres du groupe de travail pluridisciplinaire « Toxicologie et biologie clinique » appartenant à la Société française de biologie clinique (SFBC), à la Société française de toxicologie analytique (SFTA), à la Société de toxicologie clinique (STC), proposent une aide méthodologique à l’intention des biologistes non spécialistes en toxicologie. Ils formulent également pour respecter les bonnes pratiques de laboratoire un certain nombre de recommandations. Trois documents de synthèse ont été élaborés. Ils concernent d’une part, les biomarqueurs de toxicité et les anomalies métaboliques dans les principales intoxications graves et, d’autre part, les symptômes cliniques essentiels correspondant à ces intoxications, enfin des recommandations sur le prélèvement conservatoire. Pour les biomarqueurs de toxicité, le tableau de synthèse concerne une cinquantaine de xénobiotiques : les principaux symptômes, les méthodes d’identification ou de dosage disponibles en urgence, les marqueurs biologiques utiles, la décision clinique correspondante, les dosages éventuels nécessaires à la prise en charge du patient, ainsi que l’antidote lorsque celui-ci existe. En ce qui concerne les techniques, le groupe propose un certain nombre de recommandations relatives au domaine clinique et médico-légal. Le groupe insiste également sur la nécessité de procéder dans certains cas à des prélèvements biologiques conservatoires dès la prise en charge du malade, prélèvements qui seront ou ne seront pas analysés en fonction du contexte et/ou de l’évolution de l’intoxication. [less ▲]

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See detailDie Medien der Germanistik und die Nöte des Nachwuchses
Pontzen, Alexandra ULg

in Jahrbuch der Deutschen Schillergesellschaft (2003), XLVII

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See detailThe activation of birdsong by testosterone - Multiple sites of action and role of ascending catecholamine projections
Ball, G. F.; Castelino, C. B.; Maney, D. L. et al

in Annals of the New York Academy of Sciences (2003), 1007

Birdsong is a species-typical stereotypic vocalization produced in the context of reproduction and aggression. Among temperate-zone songbirds, it is produced primarily by males, and its frequency and ... [more ▼]

Birdsong is a species-typical stereotypic vocalization produced in the context of reproduction and aggression. Among temperate-zone songbirds, it is produced primarily by males, and its frequency and quality are enhanced by the presence of the gonadal steroid hormone testosterone in the plasma. In the brain, the effects of testosterone on song behavior involve both estrogenic and androgenic metabolites of testosterone that are locally produced and act via their cognate receptors. Androgen, and in some cases estrogen, receptors are present in many specialized forebrain song control nuclei. Testosterone can regulate catecholamine steady-state levels and turnover in these song control regions. Tracing studies combined with immunocytochemistry for tyrosine hydroxylase (a marker of catecholamine synthesis) reveal several catecholamine cell groups that project to forebrain song control nuclei. These brain areas also express the mRNA for either androgen receptors or estrogen receptor alpha, and androgens enhance the expression of tyrosine hydroxylase. Dopaminergic cell groups that project to song nuclei express the protein product of the immediate early gene fos in association with the production of territorial song. Thus, testosterone may be acting on song behavior via these ascending catecholamine cell groups. Chemical lesioning studies suggest that noradrenergic projections to the song system are involved in the latency to produce song and the ability to discriminate conspecific from heterospecific song. The song control circuit may thus be modulated in significant ways via the androgen regulation of forebrain catecholamine systems. [less ▲]

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See detailRilke herlezen
Spinoy, Erik ULg

in Freespace Nieuwzuid (2003), 3(12), 80

In this special issue, a number of critics reflect on the question if and how it is still possible today to take great lyrical poetry at face value. The case at hand is that of Rilke's Duino Elegies.

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See detailLes apports du projet Johns Hopkins dans la statistique du non-marchand
Mertens de Wilmars, Sybille ULg

in Non Marchand : Management, Droit et Finance (2003), (11), 29-38

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See detailAmélioration de la détection d’une maladie émergente : exemple de l’ encépahlopathie spongiforme bovine
Saegerman, Claude ULg; Berkvens, D.; Speybroeck, N. et al

in Epidémiologie et Santé Animale (2003), 44

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See detailPrediction of organoleptic and technological characteristics of pork meat by near infrared spectroscopy
Meulemans, A.; Dotreppe, Olivier ULg; Leroy, Bernadette ULg et al

in Sciences des Aliments (2003), 23(1), 159-162

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See detailVolumen-Flussmessung mit "Colour Velocity Imaging (CVI)": Technik der Messung in der intrahepatischen fetalen Vena umbilicalis
Chantraine, Frédéric ULg; Reihs, Tanja; Henrich, Wolfgang et al

in Zentralblatt für Gynakologie (2003), 125

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See detailDust-acoustic modes in plasmas with dust distributions and charge fluctuations
Verheest, F.; Jacobs, G.; Cattaert, Tom ULg

in New Journal of Physics (2003), 5

Charge fluctuations in dusty plasmas are discussed starting from charge, mass, momentum and current equations for the combined dusty plasma. This allows a generic description of low-frequency waves in ... [more ▼]

Charge fluctuations in dusty plasmas are discussed starting from charge, mass, momentum and current equations for the combined dusty plasma. This allows a generic description of low-frequency waves in plasmas with dust distributions, and leads to the damping and other modifications of the dust-acoustic and related modes, like generalized dust-Coulomb modes. [less ▲]

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See detailPhase III randomized study comparing 5 or 10 microg per kg per day of filgrastim for mobilization of peripheral blood progenitor cells with chemotherapy, followed by intensification and autologous transplantation in patients with nonmyeloid malignancies.
Andre, Marc; Baudoux, Etienne ULg; Bron, Dominique et al

in Transfusion (2003), 43(1), 50-7

BACKGROUND: It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic ... [more ▼]

BACKGROUND: It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic engraftment after autologous transplantation. STUDY DESIGN AND METHODS: A randomized, open-label, multicenter trial was carried out in patients with breast cancer, multiple myeloma, and lymphoma, in which patients were randomized to receive 5 or 10 microg per kg per day of filgrastim after standard chemotherapy to mobilize PBPCs. After high-dose chemotherapy, the components from the first two leukapheresis procedures were returned, and all patients received 5 microg per kg day of filgrastim after transplantation. RESULTS: A total of 131 patients were randomized, of whom 128 were mobilized (Group A, 5 microg/kg, n = 66; Group B, 10 microg/kg, n = 62) and 112 were transplanted. Only six patients were not transplanted because of insufficient CD34+ cell numbers. The median number of CD34+ cells collected in the first two leukapheresis procedures tended to be higher in Group B than in Group A (12.0 vs. 7.2 x 10(6)/kg, NS), but after transplantation there was no significant difference in median times to platelet (9 days in both groups) or neutrophil (8 days in both groups) engraftment or the number of platelet transfusions (three in both groups). A subsequent subgroup analysis separating patients transplanted after first- or second-line chemotherapy also showed no measurable impact of filgrastim dose on the median CD34+ cell yield or on platelet engraftment in either subgroup. CONCLUSION: PBPC mobilization with chemotherapy and 5 microg per kg of filgrastim is very efficient, and 10 microg per kg of filgrastim does not provide additional clinical benefit. [less ▲]

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See detailUne méthode générique pour la classification automatique d'images à partir des pixels
Marée, Raphaël ULg; Geurts, Pierre ULg; Wehenkel, Louis ULg

in Revue des Nouvelles Technologies de l'Information (2003), 1

Dans cet article, nous évaluons une approche générique de classification automatique d'images. Elle repose sur une méthode d'apprentissage récente qui construit des ensembles d'arbres de décision par ... [more ▼]

Dans cet article, nous évaluons une approche générique de classification automatique d'images. Elle repose sur une méthode d'apprentissage récente qui construit des ensembles d'arbres de décision par sélection aléatoire des tests directement sur les valeurs basiques des pixels. Nous proposons une variante, également générique, qui réalise une augmentation fictive de la taille des échantillons par extraction et classification de sous-fenêtres des images. Ces deux approches sont évaluées et comparées sur quatre bases de données publiques de problèmes courants: la reconnaissance de chiffres manuscrits, de visages, d'objets 3D et de textures. [less ▲]

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See detailObservation récente en Province de Liège de Velleius dilatatus (F., 1787) (Coleoptera: Staphylinidae)
Thieren, Yves; Fagot, Jean ULg; Lhoir, Jonathan

in Notes Fauniques de Gembloux (2003), 50

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See detailArterial embolization as a treatment of chronic edema following free cutaneous flap transfer to the lower limbs.
Tchuisse, Charlemagne Noukoua; Barah, Ali; NCHIMI LONGANG, Alain ULg et al

in Cardiovascular & Interventional Radiology (2003), 26(3), 316-8

Persisting chronic edema following postoperative free flap transfer is a common complication. We report 3 cases of successful treatment by selective arterial embolization of the feeding arterial branches ... [more ▼]

Persisting chronic edema following postoperative free flap transfer is a common complication. We report 3 cases of successful treatment by selective arterial embolization of the feeding arterial branches without side effect. One session embolization is advocated as a first line treatment of this condition. [less ▲]

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See detailManaging Pests : consumers and commitments: The case of apple and pear growers in Belgium's Lower Meuse Region
Collet, Eric; Mormont, Marc ULg

in Environment & Planning A (2003), 35(3), 413-427

The authors analyse the construction of a seed fruit market. The conventional market had led to the 'anonymousness' of the fruit and to disconnected temporalities. The process needs new types of ... [more ▼]

The authors analyse the construction of a seed fruit market. The conventional market had led to the 'anonymousness' of the fruit and to disconnected temporalities. The process needs new types of coordination and components within the common information channels and actors' network. It also needs the construction of a new contract between producers and consumers, that the conventional market is unable to allow. Producers are experimenting with direct contact with the final consumer to find ways of allowing it. The fruit is replaced in the subject's experience of the final consumer and in the grower's story. The grower's story deals with managing pests, consumers, and commitments through a harmless action: eating a pear or an apple. [less ▲]

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See detailFactor V inhibitor after injection of human thrombin in a bleeding ulcer.
Caers, Jo ULg; Reekmans, An; Jochmans, Kristin et al

in Endoscopy (2003), 35((6)), 542-4

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See detailNew ruthenium catalysts bearing N-heterocyclic carbene ligands for ATRP
Tudose, Adriana; Delfosse, Sébastien; Richel, Aurore ULg et al

in e-polymers (2003)

New ruthenium catalysts bearing N-heterocyclic carbene ligands in Kharasch chemistry

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See detailThe role of reactive oxygen species in homeostasis and degradation of cartilage.
Henrotin, Yves ULg; Bruckner, P.; Pujol, J. P.

in Osteoarthritis and Cartilage (2003), 11(10), 747-55

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and ... [more ▼]

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and growth factors, as well as mechanical stimuli, reactive oxygen species (ROS) emerge as major factors in this regulation. ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable. METHOD: This review is focused on the role of ROS, mainly nitric oxide, peroxynitrite and superoxide anion radicals, in the signaling mechanisms implied in the main cellular functions, including synthesis and degradation of matrix components. The direct effects of ROS on cartilage matrix components as well as their inflammatory and immunomodulatory effects are also considered. RESULTS: Some intracellular signaling pathways are redox sensitive and ROS are involved in the regulation of the production of some biochemical factors involved in cartilage degradation and joint inflammation. Further, ROS may cause damage to all matrix components, either by a direct attack or indirectly by reducing matrix components synthesis, by inducing apoptosis or by activating latent metalloproteinases. Finally, we have highlighted the uncoupling effect of ROS on tissue remodeling and synovium inflammation, suggesting that antioxidant therapy could be helpful to treat structural changes but not to relieve symptoms. CONCLUSIONS: This review of the literature supports the concept that ROS are not only deleterious agents involved in cartilage degradation, but that they also act as integral factors of intracellular signaling mechanisms. Further investigation is required to support the concept of antioxidant therapy in the management of joint diseases. [less ▲]

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See detailHistory of solid organ transplantation at the University of Liege
Lejeune, Georges ULg; Limet, Raymond ULg; Meurisse, Michel ULg et al

in Acta Chirurgica Belgica (2003), 103(3 Sp. Iss. SI), 32-36

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See detailDendrochronologie et archéologie du bâtiment
Hoffsummer, Patrick ULg

in Cahiers de l'Urbanisme (Les) (2003), 44

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See detailE-service quality expectations: a case study
Van Riel, Allard ULg; Semeijn, Janjaap; Janssen, Wendy

in Total Quality Management & Business Excellence (2003), 14(4), 437-450

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See detailLes protéines de choc thermique (heat shock proteins). II Les protéines de choc thermique (heat shock proteins). II. Hsp70, biomarqueur, bioprotecteur.
Wirth, Delphine; Gustin, Pascal ULg; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (2003), 147(2), 127-144

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was ... [more ▼]

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was initially discovered in Drosophila. The genes hsps were among the first eukaryotic genes to be cloned and whose regulation, which involves activation of heat shock factor (HSF), was elucidated. More recently, study of Hsp functions, particularly Hsp70, started. Their protective role, related to their molecular chaperon function, was inferred from experiments showing that Hsp70 expression, induced by a first stress, results in a cellular tolerance to second stress. Better understanding of the heat shock response had led to the development of two search fields on Hsp70 expression : (1) its use as biomarker of cellular stress and (2) the exploitation of its cytoprotective functions against various insults. This review includes historic of the research on the heat shock response, description of regulation mechanism of Hsp70 expression, and the interesting perspectives allocated to Hsp70 as biomarker and therapeutic tool. ----------- L’exposition de tout organisme à des températures élevées induit l'expression cellulaire rapide et transitoire de protéines spécifiques, les protéines de choc thermique (Hsps pour " heat shock proteins "). Cette réponse des cellules au choc thermique ou " heat shock response " a été initialement découverte chez la drosophile. Les gènes hsps furent parmi les premiers gènes eucaryotes à être clonés et utilisés comme paradigme dans l'étude des mécanismes de régulation transcriptionnelle faisant intervenir l'activation d'un ou plusieurs " heat shock factors" (HSFs). C'est plus récemment que l'étude des fonctions des Hsps, particulièrement Hsp70, a débuté. Le rôle protecteur de celle-ci, lié à sa fonction de " chaperon " protéique, a été déduit d'expériences montrant que l'induction de l'expression de Hsp70 lors d'un stress était associée au développement d'une tolérance cellulaire vis-à-vis d'un stress ultérieur. En plus d'un intérêt fondamental pour la compréhension de la "réponse au choc thermique", deux axes de recherche appliquée se sont développés visant à investiguer la possibilité d'utiliser l'expression de Hsp70 comme biomarqueur de souffrance cellulaire d'une part et, d'autre part, d'exploiter ses fonctions comme moyen de protection des cellules contre divers types d'agressions. Cette revue décrit l'historique des découvertes sur la " réponse au choc thermique ", le mécanisme régulant l'expression de Hsp70 ainsi que les perspectives intéressantes s'ouvrant à l'utilisation de l'expression de Hsp70 en tant que biomarqueur et outil thérapeutique. [less ▲]

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See detailXMM-Newton high-resolution X-ray spectroscopy of the Wolf-Rayet object WR25 (WN6ha+O4f)
Raassen, A. J. J.; van der Hucht, K. A.; Mewe, R. et al

in Advances in Space Research (2003), 32(6), 1161-1165

We report the analysis of the X-ray spectrum of the Wolf-Rayet star WR 25, observed by RGS and EPIC-MOS on board XMM-Newton. Temperatures up to 40 MK have been determined. Strong absorption, exceeding the ... [more ▼]

We report the analysis of the X-ray spectrum of the Wolf-Rayet star WR 25, observed by RGS and EPIC-MOS on board XMM-Newton. Temperatures up to 40 MK have been determined. Strong absorption, exceeding the value due to the Inter Stellar Medium (ISM) has been detected and assigned to the dense stellar wind. (C) 2003 COSPAR. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailEnantiomeric separation of aminoglutethimide by capillary electrophoresis using native cyclodextrins in single and dual systems
Abushoffa, A. M.; Fillet, Marianne ULg; Marini Djang'Eing'A, Roland ULg et al

in Journal of Separation Science (2003), 26(6-7), 536-542

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A ... [more ▼]

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A complete resolution of the enantiomers of this compound in cationic form could be achieved with each of the three CDs, using a pH 3 phosphoric acid-triethanolamine buffer. Affinity constants for AGT enantiomers with the three native CDs were determined, confirming that the highest selectivity was given by gamma-CD while the strongest complexation was obtained with beta-CD. However, an opposite affinity pattern was observed with the latter. Selectivity was lower for AGT enantiomers in dual CD systems, compared to that obtained with a single selector at its optimal concentration, which confirms that dual systems are of more limited interest when the two selectors have a similar effect on the analyte mobility. These results are in good agreement with those predicted using recently developed mathematical models. [less ▲]

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See detailHigh-Performance Liquid Chromatography Analyses Of Pyoverdin Siderophores Differentiate Among Phytopathogenic Fluorescent Pseudomonas Species
Bultreys, Alain; Gheysen, Isabelle; Wathelet, Bernard ULg et al

in Applied and Environmental Microbiology (2003), 69(2),

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See detailUn monde de rejetés
Dumortier, Jean-Louis ULg

in Traces (2003), 14

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See detailFinding the lost Iris sofarana Foster
Saad, Layla ULg

in Aril Society International Yearbook (2003)

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See detailFormation continue en jonglerie
Fischbach, Willi; Cloes, Marc ULg

in Revue de l'Education Physique (2003), 43(4), 114-125

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de ... [more ▼]

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de formations continuées proposées aux maîtres de stage qui collaborent à la formation des étudiants de l’AESS de l’Institut Supérieur d’Education Physique et de Kinésithérapie de l’ULg. [less ▲]

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See detailCalculation of the scattering coefficient of a sine-shaped surface by solving the Helmholtz integral
Embrechts, Jean-Jacques ULg; De Geetere, L.; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 67-74

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See detailThe Macrolide Antibiotic Azithromycin Interacts With Lipids And Affects Membrane Organization And Fluidity: Studies On Langmuir-Blodgett Monolayers, Liposomes And J774 Macrophages
Tyteca, D.; Schanck, A.; Dufrene, Yf. et al

in Journal of Membrane Biology (2003), 192(3), 203-215

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See detailL'assurance dépendance: quels risques à assurer?
Jousten, Alain ULg

in Risques (2003), 55

La perte d'autonomie est un thème d'actualité dans bon nombre de pays développés, notamment vu le processus de vieillissement démographique qui est en cours. Malgré ce constat commun à la majeure partie ... [more ▼]

La perte d'autonomie est un thème d'actualité dans bon nombre de pays développés, notamment vu le processus de vieillissement démographique qui est en cours. Malgré ce constat commun à la majeure partie des pays, les réponses apportées ou proposées dans les différents pays semblent différer de façon fondamentale. Nous proposons différentes classifications qui permettent de mieux comprendre les enjeux quant à l'étendue et le financement des prestations couvertes par les systèmes d'assurance dépendance. [less ▲]

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See detailQuelle formation andragogique pour les enseignants universitaires demain ?
Schmitz, Serge ULg

in Actes du Geoforum (2003), 27

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See detailIdentités et valeurs politiques : quelle homogénéité pour l'Eurégio ?
Jacquemain, Marc ULg

in Fédéralisme - Régionalisme (2003)

Euregio Mosa-Rhine is a euregional structure that agregates Province of Liege and German-speaking belgian community (Belgium) Province of Limburg (Belgium), Province of South-Limburg (Netherlands) and ... [more ▼]

Euregio Mosa-Rhine is a euregional structure that agregates Province of Liege and German-speaking belgian community (Belgium) Province of Limburg (Belgium), Province of South-Limburg (Netherlands) and Regio Aachen (Germany). It is supposed to be an area with many commercial and cultural inter-relations. Throuth a survey led in 2002, the paper tries to assess cultural similitaries and differences between the five components at the level of social identity and political values. It shows a contrasted landscape where the two dutch-speaking parts being more individualist, the german part being more comunitarian and, at the heart, the province of Liege more materialist and egalitarian. [less ▲]

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See detailUne évocation pythagoricienne des Enfers chez Tibulle (I, 3, 59-66)
Rochette, Bruno ULg

in Etudes Classiques (2003), 71(2), 175-180

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See detailL'etude clinique du mois Quel antihypertenseur en premiere intention? Resultats de l'etude ALLHAT.
Scheen, André ULg; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2003), 58(1), 47-52

Antihypertensive therapy is well established to reduce hypertension-related morbidity and mortality, but the optimal first-step therapy is still controversial. The "Antihypertensive and Lipid-Lowering ... [more ▼]

Antihypertensive therapy is well established to reduce hypertension-related morbidity and mortality, but the optimal first-step therapy is still controversial. The "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial" (ALLHAT) should give such an answer. It is a randomised, double-blind, trial designed to determine whether treatment with either a calcium channel blocker or an angiotensin-converting enzyme inhibitor lowers the incidence of coronary heart disease (CHD) or other cardiovascular disease (CVD) events vs treatment with a diuretic. A total of 33,357 participants aged 55 years or older with mild to moderate hypertension and at least 1 other CHD risk factor were randomly assigned to receive chlorthalidone (12.5 to 25 mg/day; n = 15,255), amlodipine (2.5 to 10 mg/day; n = 9,048) or lisinopril (10 to 40 mg; n = 9,054). The primary outcome combined both fatal CHD and non-fatal myocardial infarction, analyzed by intent-to-treat. Secondary outcomes were all-causes mortality, stroke, combined CHD (primary outcome, coronary revascularization, or angina with hospitalization), and combined CVD (combined CHD, stroke, treated angina without hospitalization, heart failure and peripheral arterial disease). Chlorthalidone was slightly more effective in reducing systolic pressure while amlodipine reduced slightly more effectively diastolic blood pressure. After a mean follow up of 4.9 years, no differences were observed between the three treatments regarding both the primary outcome and the total mortality. Secondary outcomes were similar when comparing amlodipine vs chlorthalidone. A moderately higher 6-year incidence rate of clinically detected heart failure was observed with amlodipine, but without significant influence on mortality. For lisinopril vs chlorthalidone, lisinopril had slightly higher 6-year rates of combined CVD, stroke and heart failure. In conclusion, thiazide-type diuretics are superior in preventing one or more major forms of CVD and offer the advantage to be cheaper. They should be preferred for first-step antihypertensive therapy. However, to reach the recommended blood pressure target, most patients should receive a combination of antihypertensive compounds. Such a combination should always comprise a diuretic agent, in absence of contra-indications. [less ▲]

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See detailDe ereburgers. Een sociale geschiedenis van de Limburgse mijnwerkers
Geerkens, Eric ULg

in Cahiers d'Histoire du Temps Présent = Bijdragen tot de Eigentijdse Geschiedenis (2003), 11

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See detailExamen de jurisprudence (1995-2001). Contrat de travail
Kefer, Fabienne ULg; Clesse, Jacques ULg

in Revue Critique de Jurisprudence Belge (2003)

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See detailEffect of nutrient enrichments on the bacterial assemblage of Antarctic soils contaminated by diesel or crude oil
Delille, Daniel; Pelletier, Emilien; Delille, Bruno ULg et al

in Polar Record (2003), 39(4), 309-318

There is an urgent need to develop new technologies to address the problem of soil remediation in high-latitude regions. A field study was initiated in January 1997 in two contaminated soils in Terre ... [more ▼]

There is an urgent need to develop new technologies to address the problem of soil remediation in high-latitude regions. A field study was initiated in January 1997 in two contaminated soils in Terre Adélie (Antarctica) with the objective of determining the long-term effectiveness of two bioremediation agents on total and hydrocarbon-degrading microbial assemblages under severe Antarctic conditions. This study was conducted in two steps, from January to July 1997 and from February to November 1999 in the Géologie Archipelago (Terre Adélie, 66°40′S, 140°01′E). Changes in bacterial communities were monitored in situ after crude oil or diesel addition in a series of 600 cm2 soil sectors (20×30 cm). Four contaminated sectors were used for each experiment: diesel oil (10 ml), diesel oil (10 ml) + fertilizer (1 ml), Arabian light crude oil (10 ml), and crude oil (10 ml) + fertilizer (1 ml). Two different bioremediation agents were used: a slow release fertilizer Inipol EAP-22 (Elf Atochem) in 1997 and a fish compost in 1999. Plots were sampled on a regular basis during a three-year period. All samples were analysed for total, saprophytic psychrophilic, and hydrocarbon-utilising bacteria. A one order of magnitude increase of saprophytic and hydrocarbon-utilising micro-organisms occurred during the first month of the experiment in most of the contaminated enclosures, but no clear differences appeared between fertilized and unfertilized plots. Diesel-oil contamination induced a significant increase of all bacterial parameters in all contaminated soils. Crude-oil contamination had no clear effects on microbial assemblages. It was clear that the microbial response could be rapid and efficient in spite of the severe weather conditions. However, microbial growth was not clearly improved in the presence of bioremediation agents. [less ▲]

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See detailBibliographie matérielle et critique textuelle. À propos de l'édition de 1751 des Pensées philosophiques de Diderot
Droixhe, Daniel ULg

in Recherches sur Diderot et l'Encyclopédie (2003), 34

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See detailMeasure Noun constructions : an instance of semantically-driven grammaticalization
Brems, Lieselotte ULg

in International Journal of Corpus Linguistics (2003), 8(2), 283-312

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See detailL'etude clinique du mois. L'etude ALLHAT-LLT.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2003), 58(1), 53-8

ALLHAT-LLT was part of the ALLHAT study. The purpose was to determine whether pravastatin compared with usual care reduces all-cause mortality in older, moderately hypercholesterolaemic, hypertensive ... [more ▼]

ALLHAT-LLT was part of the ALLHAT study. The purpose was to determine whether pravastatin compared with usual care reduces all-cause mortality in older, moderately hypercholesterolaemic, hypertensive patients with at least one additional coronary heart disease (CHD) risk factor. 10,355 ambulatory patients, aged 55 years or more, with LDL cholesterol of 120-189 mg/dl (or, 100-129 mg/dl if known CHD) and triglycerides < 350 mg/dl, were randomised to pravastatin (40 mg/d; n = 5,170), or usual care (n = 5,185). Mean age was 66 years; 49% were women; 38% were black and 23% hispanic; 14% had a history of CHD and 35%, type 2 diabetes. Baseline mean total cholesterol was 224 mg/dl; LDL-C, 146 mg/dl; HDL-C, 48 mg/dl, and triglycerides, 152 mg/dl. Mean follow-up was 4.8 years. Among usual care patients, 32% of those with known CHD and 29% of those without CHD started taking lipid-lowering drugs. At year 4, total cholesterol was reduced by 17.2% with pravastatin and by 7.6% with usual care. A random sample had their LDL-C levels assessed: there was a reduction of 28% with pravastatin and of 11% with usual care. All-cause mortality was similar in the two groups (RR, 0.99; 95% CI, 0.89-1.11; p = 0.88), with 6-year mortality rates of 14.9% (pravastatin) and 15.3% (usual care). CHD event-rates were not different between the two groups (RR, 0.91; 95% CI, 0.79-1.04; p = 0.16); 6-year CHD event rates were 9.3% (pravastatin) and 10.4% (usual care), respectively. These results are likely due to the small differential in total cholesterol (9.6%) and LDL-C (16.7%) between pravastatin and usual care, compared with prior statin trials. Such an unusual differential essentially results from the open table of the study and from the possibility of prescribing a statin in the usual care group. [less ▲]

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See detailPièges de la chirurgie coelioscopique: comment faire face aux complications?
Joris, Jean ULg; Kaba, Abdourahmane ULg

in Praticien en Anesthésie Réanimation (Le) (2003), 7(5), 339-345

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See detailEfficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study
van de Putte, L. B. A.; Rau, R.; Breedveld, F. C. et al

in Annals of the Rheumatic Diseases (2003), 62(12), 1168-1177

OBJECTIVES: To evaluate efficacy, dose response, safety, and tolerability of adalimumab (D2E7) in disease modifying antirheumatic drug (DMARD) refractory patients with longstanding, active rheumatoid ... [more ▼]

OBJECTIVES: To evaluate efficacy, dose response, safety, and tolerability of adalimumab (D2E7) in disease modifying antirheumatic drug (DMARD) refractory patients with longstanding, active rheumatoid arthritis (RA). METHODS: During a 12 week, double blind, placebo controlled study, 284 patients were randomly allocated to receive weekly subcutaneous injections of adalimumab 20 mg (n = 72), 40 mg (n = 70), or 80 mg (n = 72) or placebo (n = 70) without concomitant DMARDs. RESULTS: Adalimumab significantly improved the signs and symptoms of RA for all efficacy measures. ACR20 responses with adalimumab were significant at each assessment versus placebo (p</=0.01). Additionally, ACR responses with adalimumab were achieved more rapidly than with placebo, with 82/115 (71%) of the ultimate ACR20 response rate to adalimumab treatment achieved at week 2. At week 12, for adalimumab 20, 40, and 80 mg, ACR20 response rates were 50.7%, 57.1%, and 54.2%, respectively, versus 10.0% for placebo (p</=0.001 for all comparisons); ACR50 rates were 23.9%, 27.1%, and 19.4%, respectively, versus 1.4% for placebo (p</=0.001 for all comparisons); and ACR70 rates were 11.3%, 10.0%, and 8.3%, respectively, versus 0.0% for placebo (p</=0.05 for all comparisons). All adalimumab doses significantly improved all ACR core criteria at all assessments. The 40 mg and 80 mg doses provided similar benefit. Adalimumab at all doses was generally well tolerated, with only mild or moderate adverse events. Completion rates were 87% for adalimumab and 67% for placebo. CONCLUSIONS: Adalimumab given as monotreatment to patients with longstanding, severe RA refractory to traditional DMARDs produced a rapid, sustained response and was safe and well tolerated, with no dose limiting side effects. [less ▲]

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See detailL’émergence d’un marché d’immobilier d’entreprise. L’exemple de la Wallonie
Merenne-Schoumaker, Bernadette ULg

in Géocarrefour (2003), 78

In less than ten years, a business property market has emerged in Wallonia. This market first concerned offices and retail units (a sector not studied in this paper) and, more recently, semi-industrial ... [more ▼]

In less than ten years, a business property market has emerged in Wallonia. This market first concerned offices and retail units (a sector not studied in this paper) and, more recently, semi-industrial establishments. Its development is largely related to the creation of new demands in physical units, environment and accessibility, as well as in location choices, at both sub-regional and local scales. It has been favoured by the arrival of new property stakeholders from Belgium and abroad (developers, investors and property agents), as well as by public authorities (the Walloon Region and, more importantly, supra-communal, economic development agencies). The emergence of this market is related to the accentuation of territorial contrasts as property development projects usually reinforce strong area [less ▲]

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See detailTranscription-coupled TA and GC strand asymmetries in the human genome
Touchon, M.; Nicolay, Samuel ULg; Arneodo, Alain et al

in FEBS Letters (2003), 555

Abstract Analysis of the whole set of human genes reveals that most of them present TA and GC skews, that these biases are correlated to each other and are speci¢c to gene sequences, exhibiting sharp ... [more ▼]

Abstract Analysis of the whole set of human genes reveals that most of them present TA and GC skews, that these biases are correlated to each other and are speci¢c to gene sequences, exhibiting sharp transitions between transcribed and non-tran- scribed regions. The GC asymmetries cannot be explained solely by a model previously proposed for (G+T) skew based on tran- sitions measured in a small set of human genes. We propose that the GC skew results from additional transcription-coupled mu- tation process that would include transversions. During evolu- tion, both processes acting on a large majority of genes in germ- line cells would have produced these transcription-coupled strand asymmetries. [less ▲]

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See detailObservations sous Mons, 25 mars 2002
Leleu, Yves-Henri ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailInteraction Of Surfactin With Membranes: A Computational Approach
Deleu, Magali ULg; Bouffioux, O.; Razafindralambo, Hary ULg et al

in Langmuir (2003), 19(8),

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See detailRole of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase.
Vanhove, Marc; Zakhem, M.; Devreese, B. et al

in Cellular and molecular life sciences : CMLS (2003), 60(11), 2501-9

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results ... [more ▼]

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results in a drastic decrease in the hydrolytic activity. In this study, we analyzed the role of Asn116 and Cys221, two residues of the active site. These residues were replaced by site-directed mutagenesis and the different mutants were characterized. The C221S and C221A mutants were seriously impaired in their ability to bind the first, catalytic zinc ion and were nearly completely inactive, indicating a major role for Cys221 in the binding of the catalytic metal ion. By contrast, the binding of the second zinc ion was only slightly affected, at least for the C221S mutant. Mutation of Asn116 did not lead to a drastic decrease in the hydrolytic activity, indicating that this residue does not play a key role in the catalytic mechanism. However, the substitution of Asn116 by a Cys or His residue resulted in an approximately fivefold increase in the affinity for the second, inhibitory zinc ion. Together, these data suggested that the first zinc ion is located in the binding site involving the Cys221 and that the second zinc ion binds in the binding site involving Asn116 and, presumably, His118 and His196. [less ▲]

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See detailLiège-Paris 1848 : Littérature, féminisme et Révolution
Droixhe, Daniel ULg

in Bulletin de l'Académie Royale de Langue et de Littérature Françaises (2003), LXXXI(1-2), 41-49

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See detailCharacterization of UDP-glucose : protein transglucosylase genes from potato.
Wald, F. A.; Kissen, R.; du Jardin, Patrick ULg et al

in Plant Molecular Biology (2003), 52

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See detailCell cycle duration at the time of maternal zygotic transition for in vitro produced bovine embryos: effect of oxygen tension and transcription inhibition.
Lequarré, Anne-Sophie ULg; Marchandise, J.; Massip, A. et al

in Biology of Reproduction (2003), 69(5), 1707-13

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to ... [more ▼]

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to assess embryo quality. The goal of this study was to evaluate the duration of the fourth cell cycle, at the time of maternal-to-zygotic transition (MZT) in in vitro-produced bovine embryos by means of cinematographic analysis. We found that 75% of the embryos displayed a long fourth cycle (43.5 +/- 5.4 h) whereas the remaining embryos had a very short fourth cell cycle (8.9 +/- 2.9 h). Both groups did not differ in cleavage rhythm up to the eight-cell stage and timing of cavitation and blastocyst expansion was identical. However, embryos with a short fourth cell cycle had a better blastocyst rate than embryos with a long cycle (59% versus 38%, P < 0.01). Total cell number, inner cell mass (ICM):total cell ratio, and hatching rate were identical for blastocysts produced from embryos with either a long or a short fourth cell cycle. In a second experiment, we showed that increasing the oxygen tension, from 5% to 20%, decreased the percentage of embryos with a short fourth cell cycle, from 25% to 11% (P < 0.01), indicating that suboptimal culture conditions can influence the length of this cycle. Finally, we investigated whether fourth cell cycle duration could be influenced by transcription inhibition. With alpha-amanitin added at 18 h postinsemination (HPI), cleavage was reduced (66% versus 79%) and, at 70 HPI, the 9- to 16-cell rate increased (50% versus 25%) concomitantly with a 5- to 8-cell rate decrease (16% versus 47%). A similar pattern was observed when the drug was added at 6 HPI or 42 HPI but not at 0 HPI. Cinematographic analysis revealed that alpha-amanitin increased the first cell cycle duration whereas the second and third cell cycles were not affected. With the drug, one third of the embryos could develop up to the 9- to 16-cell stage and they all had a short fourth cell cycle (11.2 +/- 3.7 h) with a good synchrony of cleavage between blastomeres. These results suggest that duration of the fourth cell cycle of bovine embryo, during the MZT, is under a zygotic transcriptional control that can be affected by oxidative conditions. [less ▲]

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See detailInduction of potato (Solanum tuberosum L.) tuber sprouting by hydrogen peroxide.
Bajji, M.; M'Hamdi, M.; Gastiny, F. et al

in Free Radical Research (2003), 37

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See detailEffect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
Mogensen, Carl Erik; Viberti, Giancarlo; Halimi, Serge et al

in Hypertension (2003), 41(5), 1063-71

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril ... [more ▼]

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP > or =140 mm Hg, <180 mm Hg, diastolic BP <110 mm Hg) were randomly assigned (age 59+/-9 years, 77% previously treated for hypertension). Results from 457 patients (intention-to-treat analysis) were available. After a 4-week placebo period, patients with albuminuria >20 and <500 microg/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg enalapril. The main outcome measures were overnight AER and supine BP. Both treatments reduced BP. Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3.0 [95% CI -5.6, -0.4], P=0.012; systolic BP -1.5 [95% CI -3.0, -0.1] diastolic BP P=0.019) and AER -42% (95% CI -50%, -33%) versus -27% (95% CI -37%, -16%) with enalapril. The greater AER reduction remained significant after adjustment for mean BP. Adverse events were similar in the 2 groups. Thus, first-line treatment with low-dose combination perindopril/indapamide induces a greater decrease in albuminuria than enalapril, partially independent of BP reduction. A BP-independent effect of the combination may increase renal protection. [less ▲]

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See detailLipides, dépression et suicide
Colin, A.; Reggers, Jean ULg; Castronovo, Vincenzo ULg et al

in Encéphale (L') (2003), 29(1, JAN-FEB), 49-58

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 ... [more ▼]

Polyunsatured fatty acids are made out of a hydrocarbonated chain of variable length with several double bonds. The position of the first double bond (omega; omega) differentiates polyunsatured omega3 fatty acids (for example : alpha-linolenic acid or alpha-LNA) and polyunsatured omega6 fatty acids (for example : linoleic acid or LA). These two classes of fatty acids are said to be essential because they cannot be synthetised by the organism and have to be taken from alimentation. The omega3 are present in linseed oil, nuts, soya beans, wheat and cold water fish whereas omega6 are present in maize, sunflower and sesame oil. Fatty acids are part of phospholipids and, consequently, of all biological membranes. The membrane fluidity, of crucial importance for its functionning, depends on its lipidic components. Phospholipids composed of chains of polyunsatured fatty acids increase the membrane fluidity because, by bending some chains, double bonds prevent them from compacting themselves perfectly. Membrane fluidity is also determined by the phospholipids/free cholesterol ratio, as cholesterol increases membrane viscosity. A diet based on a high proportion of essential polyunsatured fatty acids (fluid) would allow a higher incorporation of cholesterol (rigid) in the membranes to balance their fluidity, which would contribute to lower blood cholesterol levels. Brain membranes have a very high content in essential polyunsatured fatty acids for which they depend on alimentation. Any dietary lack of essential polyunsatured fatty acids has consequences on cerebral development, modifying the activity of enzymes of the cerebral membranes and decreasing efficiency in learning tasks. Epidemiological data - The prevalence of depression seems to increase continuously since the beginning of the century. Though different factors most probably contribute to this evolution, it has been suggested that it could be related to an evolution of alimentary patterns in the Western world, in which polyunsatured omega fatty acids contained in fish, game and vegetables have been largely replaced by polyunsatured omega6 fatty acids of cereal oils. Some epidemiological data support the hypothesis of a relation between lower depression and/or suicide rates and a higher consumption of fish. These data do not however prove a relation of causality. Cholesterol and depression - Several cohort studies (on nondepressed subjects) have assessed the relationship between plasma cholesterol and depressive symptoms with contradictory results. Though some results found a significant relationship between a decrease of total cholesterol and high scores of depression, some other did not. Studies among patients suffering from major depression signalled more constantly an association between low cholesterol and major depression. Besides, some trials showed that clinical recovery maybe associated with a significant increase of total cholesterol. Cholesterol and suicidal behaviour - The hypothesis that a low cholesterol level may represent a suicidal risk factor was discovered accidentally following a series of epidemiological studies which revealed an increase of the suicidal risk among subjects with a low cholesterol level. Though some contradictory studies do exist, this relationship has been confirmed by several subsequent cohort studies. These findings have challenged the vast public health programs aimed at promoting the decrease of cholesterol, and even suggested to suspend the administration of lipid lowering drugs. Recent clinical studies on populations treated whith lipid lowering drugs showed nevertheless a lack of significant increase of mortality, either by suicide or accident. In addition, several controlled studies among psychiatric patients revealed a decrease of the concentrations of plasma cholesterol among patients who had attempted suicide in comparison with other patients. Polyunsaturated fatty acids and depression - In major depression, all studies revealed a significant decrease of the polyunsaturated omega3 fatty acids and/or an increase of the omega6/omega3 ratio in plasma and/or in the membranes of the red cells. In addition, two studies found a higher severity of depression when the level of polyunsaturated omega fatty acids or the ratio omega3/omega6 was low. Parallel to these modifications, other biochemical perturbations have been reported in major depression, particularly an activation of the inflammatory response system, resulting in an increase of the pro-inflammatory cytokines (interleukins: IL-1beta, IL-6 and interferon gamma) and eicosanoids (among others, prostaglandin E2) in the blood and the CSF of depressed patients. These substances cause a peroxidation and, consequently a catabolism of membrane phospholipids, among others those containing polyunsaturated fatty acids. The cytokines and eicosanoids derive from polyunsaturated fatty acids and have opposite physiological functions according to their omega or omega6 precursor. Arachidonic acid (omega6) is, among others, precursor of pro-inflammatoty prostaglandin E2 (PGE2), whereas polyunsaturated W fatty acids inhibit the formation of PGE2. It has been shown that a dietary increase of polyunsaturated W fatty acids reduced strongly the production of IL-1beta, IL-2, IL-6 and TNF-alpha (tumor necrosis factor-alpha). In contrast, diets with a higher supply of linoleic acid (omega6) increased significantly the production of pro-inflammatory cytokines, like TNF-alpha. Therefore, polyunsaturated omega3 fatty acids could be associated at different levels in the pathophysiology of major depression, on the one hand through their role in the membrane fluidity which influences diverse steps of neurotransmission and, on the other hand, through their function as precursor of pro-inflammatory cytokines and eicosanoids disturbing neurotransmission. In addition, antidepressants could exhibit an immunoregulating effect by reducing the release of pro-inflammatory cytokines, by increasing the release of endogenous antagonists of pro-inflammatory cytokines like IL-10 and, finally, by acting like inhibitors of cyclo-oxygenase. Therapeutic use of fatty acids - Data available concerning the administration of supplements of DHA (docosahexanoic acid) or other polyunsaturated fatty acids omega3 are limited. In a double blind placebo-controlled study on 30 patients with bipolar disorder, the addition of polyunsaturated omega3 fatty acids was associated with a longer period of remission. Moreover, nearly all the other prognosis measures were better in the omega3 group. Very recently, a controlled trial showed the benefits of adding an omega3 fatty acid, eicosopentanoic acid, among depressed patients. After 4 weeks, six of the 10 patients receiving the fatty acid were considered as responders in comparison with only one of the ten patients receiving placebo. Conclusions Some epidemiological, experimental and clinical data favour the hypothesis that polyunsaturated fatty acids could play a role in the pathogenesis and/or the treatment of depression. More studies however are needed in order to better precise the actual implication of those biochemical factors among the various aspects of depressive illness. [less ▲]

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See detailUn droit pénal européen : hasard ou nécessité
Flore, Daniel ULg

in Revue de Droit Pénal et de Criminologie (2003), 9

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See detailRadiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL : étude prospective de phase II
Zouhair, A; COUCKE, Philippe ULg; Azria, D. et al

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (2003), 7

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods ... [more ▼]

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. – Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43–81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI) * Auteur correspondant. Adresse e-mail : abderrahim.zouhair@chuv.hospvd.ch (A. Zouhair). Cancer/Radiothérapie 7 (2003) 231–236 www.elsevier.com/locate/canrad © 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits réservés. doi:10.1016/S1278-3218(03)00041-6 was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam RT 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. – According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0–16). No grade 4 toxicity was observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, and actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion. – The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fractions per week) is feasible with local control rates comparable to that of published data. Acute RT-related morbidity is acceptable. [less ▲]

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See detailTelomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry
Rosu, Frédéric ULg; Gabelica, Valérie ULg; Shin-ya, Kazuo et al

in Chemical Communications (2003), (21), 2702-2703

Electrospray mass spectrometry (ESI-MS) was used to monitor the kinetics of duplex formation between the human telomeric DNA quadruplex and its complementary strand; the complexation of telomestatin to ... [more ▼]

Electrospray mass spectrometry (ESI-MS) was used to monitor the kinetics of duplex formation between the human telomeric DNA quadruplex and its complementary strand; the complexation of telomestatin to the G-quadruplex delays the unwinding of the quadruplex structure and formation of the duplex. [less ▲]

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See detailDu Séminaire de Géographie au Département de Géographie, Cent ans de géographie à l’Université de Liège, 1903-2003
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (2003), (43), 3-17

100-year history of teaching and research in geography at the University of Liege

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See detailEvaluation of thyroid function in obese dogs and in dogs undergoing a weight loss protocol
Daminet, Sylvie; Jeusette, Isabelle; Duchateau, L. et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (2003), 50(4), 213-218

Obesity and weight loss have been shown to alter thyroid hormone homeostasis in humans. In dogs, obesity is the most common nutritional problem encountered and weight loss is the cornerstone of its ... [more ▼]

Obesity and weight loss have been shown to alter thyroid hormone homeostasis in humans. In dogs, obesity is the most common nutritional problem encountered and weight loss is the cornerstone of its treatment. Therefore, it is important to clarify how obesity and weight loss can affect thyroid function test results in that species. The objectives of this study were to compare thyroid function in obese dogs and in lean dogs and to explore the effects of caloric restriction and weight loss on thyroid hormone serum concentrations in obese dogs. In the first experiment, 12 healthy lean beagles and 12 obese beagles were compared. Thyroid function was evaluated by measuring serum concentrations of total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), thyrotropin (TSH), and reverse triiodothyronine (rT3) as well as a TSH stimulation test using 75 mu g IV of recombinant human TSH. In the second experiment, eight obese beagles were fed an energy-restricted diet [average 63% maintenance energy requirement (MER)] until optimal weight was obtained. Blood samples for determination of TT4, FT4, TT3, TSH and rT3, were taken at the start and then weekly during weight loss. Only TT3 and TT4 serum concentrations were significantly higher in obese dogs as compared to lean dogs. In the second experiment, weight loss resulted in a significant decrease in TT3 and TSH serum concentrations. Thus obesity and energy restriction significantly alter thyroid homeostasis in dogs, but the observed changes are unlikely to affect interpretation of thyroid function test results in clinics. [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

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See detailEvent-related potentials to emotional and neutral stimuli in alcoholism.
Hansenne, Michel ULg; Olin, Cecile; Pinto, Emmanuel ULg et al

in Neuropsychobiology (2003), 48(2), 77-81

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated ... [more ▼]

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated. Subjects were 10 alcoholic inpatients (3 female) and 10 age- and sex-matched controls. Eight alcohol-related and 8 neutral words served as stimuli in a visual oddball paradigm. Acohol-related words were targets (48 stimuli, 33%) and neutral words were standard stimuli (96 stimuli, 66%). Results showed that P300 amplitude for targets did not differ significantly between the two groups. However, P300 latency for targets as well as reaction time were significantly shorter in male alcoholic patients. In contrast, P300 latency was increased in female alcoholic patients but reaction time did not differ. These results suggest that male alcoholics process information linked to alcohol cues more rapidly than neutral cues, probably because a specific semantic network is activated in these patients. The decreased reaction time confirms the impulsive behavior frequently found in male alcoholism, as it has been described in type II alcoholism. Besides, the results imply that information processing was delayed in female alcoholic patients. Therefore this study demonstrates a gender-dependent impact of alcohol-related stimuli on information processing. [less ▲]

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See detailOptimisation de la transformation génétique de la pomme de terre par Agrobacterium tumefaciens. Utilisation de la résistance à l'hygromycine comme marqueur sélectif.
M'Hamdi, M.; Rouvière, C.; Rojas-Beltran J et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7

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See detailPerfluorocarbons and Haemoglobin Solutions: Will They Ever Reach Clinical Practice?
Lamy, Maurice ULg; Deby-Dupont, G.

in Acta Anaesthesiologica Belgica (2003), 54(4), 299-300

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See detailFestina lente: evidences for fast and slow learning processes and a role for sleep in human motor skill learning.
Maquet, Pierre ULg; Laureys, Steven ULg; Perrin, Fabien et al

in Learning & Memory (Cold Spring Harbor, N.Y.) (2003), 10(4), 237-9

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See detailChronique de la 56ème Session de la Société Internationale Fernand de Visscher à Cagliari (17-21 Septembre 2002)
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (2003), L

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See detailA General Method for the Frequency Domain FE Modelling of Rotating Electromagnetic Devices
Gyselinck, J.; Vandevelde, L.; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (2003), 39(3), 1147--1150

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See detailShellfish, a dangerous food?
China, Bernard; de Schaetzen, Marie-Athénaïs ULg; Daube, Georges ULg

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 413-422

Sea products are consumed worldwide. Seafood, especially shellfish, is consumed crude or not well cooked therefore they are risky for the development of foodborne diseases. Moreover, these animals filter ... [more ▼]

Sea products are consumed worldwide. Seafood, especially shellfish, is consumed crude or not well cooked therefore they are risky for the development of foodborne diseases. Moreover, these animals filter water and concentrate the microorganisms and the toxins. Risks are multiple : bacteria (Clostridium, Vibrio), viruses (norovirus, hepatitis A) and the biotoxins (paralytic, neurotoxic, diarrhoeic and amnesic) produced by phytoplankton. The European regulation 91/492/EC indicates the microbiological and toxicological criteria for the sale of the shellfish. Nevertheless, in the absence of good diagnosis methods, the viruses were omitted in this regulation. But it is a major cause of toxi-infection due to shellfish consumption. The large number of outbreaks worldwide due to the ingestion of seafood indicates that these ones must be carefully controlled. Therefore, we need powerful diagnosis tools. The aim of this review is to describe the major biological risks (bacteria, viruses, biotoxins) for the human health linked to the consumption of sea food. [less ▲]

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See detailMemory processing during human sleep as assessed by functional neuroimaging.
Maquet, Pierre ULg; Peigneux, Philippe ULg; Laureys, Steven ULg et al

in Revue Neurologique (2003), 159(11 Suppl), 627-9

Sleep is believed to participate in memory consolidation, possibly through off-line processing of recent memory traces. In this paper, we summarize functional neuroimaging data testing this hypothesis ... [more ▼]

Sleep is believed to participate in memory consolidation, possibly through off-line processing of recent memory traces. In this paper, we summarize functional neuroimaging data testing this hypothesis. First, sleep deprivation disrupts the processing of recent memory traces and hampers the changes in functional segregation and connectivity which underpin the gain in performance usually observed in subjects allowed to sleep on the first post-training night. Second, experience-dependent changes in regional brain activity occur during post-training sleep. These changes are shown to be related to the processing of high-level material and to be modulated by the amount of learning achieved during the training session. These changes do not involve isolated brain areas but entire macroscopic cerebral networks. These data suggest a role for sleep in the processing of recent memory traces. [less ▲]

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See detailHC gp-39 gene is upregulated in glioblastomas.
Shostak, Kateryna ULg; Labunskyy, Vyacheslav; Dmitrenko, Vladimir et al

in Cancer Letters (2003), 198(2), 203-10

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression ... [more ▼]

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression (SAGE). Analysis revealed HC gp-39 among the genes with the most pronounced changes of expression in tumor cells. Northern hybridization confirmed the results of computer analysis and showed that enhanced expression of the HC gp-39 gene was mainly in GBMs and occasionally in anaplastic astrocytomas. Neither SAGE nor Northern analysis revealed the presence of HC gp-39 mRNA in the glioblastoma cell line, thus the detection of increased quantities of this mRNA in GBMs may be associated with activated macrophages. Since the numbers of infiltrating macrophages and small vessel density are higher in glioblastomas than in anaplastic astrocytomas or astrocytomas, the HC gp-39 gene can be used as a molecular marker in the analysis of malignant progression of astrocytic gliomas. [less ▲]

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