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See detailResponses to mCPP stimulation in depressed patients.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in American Journal of Psychiatry (The) (1995), 152(12), 18341834-5

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See detailCharacterization of monoclonal antibodies against stromelysin-3 and their use to evaluate stromelysin-3 levels in breast carcinoma by semi-quantitative immunohistochemistry
Santavicca, M.; Noël, Agnès ULg; Chenard, M. P. et al

in International Journal of Cancer = Journal International du Cancer (1995), 64(5), 336-341

Stromelysin-3 (ST3) is a matrix metalloproteinase which is expressed in fibroblastic cells of most human invasive carcinomas and represents a potential new prognostic indicator. Expression of recombinant ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase which is expressed in fibroblastic cells of most human invasive carcinomas and represents a potential new prognostic indicator. Expression of recombinant ST3 forms in Escherichia coli from cDNA constructs indicated that high levels of expression were achieved when the ST3 pro-domain was deleted. The putative mature form of ST3 thus produced and recovered from bacterial inclusion bodies was used to prepare monoclonal antibodies (MAbs) against ST3 by immunization of BALB/C mice. Ten hybridomas producing MAbs against ST3 were obtained and analyzed for their ability to detect endogenous ST3 in breast cancer and in conditioned media from human fibroblasts. One of these MAbs (5ST-4A9) was found to be suitable for the routine detection of ST3 on breast cancer tissue sections, thus opening the possibility to evaluate ST3 prognostic value in breast cancer using semi-quantitative immunohistochemistry [less ▲]

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See detailLes activateurs de canaux potassiques: étude structurale comparative du pinacidil, du diazoxide et du cromakalim
Dupont, Léon ULg; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Annales Pharmaceutiques Françaises (1995), 53(5), 201-208

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers ... [more ▼]

A conformational analysis has been performed with SYBYL starting from the energy optimized (Tripos force field) X-ray conformation of (R,S)-pinacidil. The geometry of four selected low energy conformers has been reoptimized using the AM1 semiempirical Molecular Orbital method (MOPAC 5.0), and the total energy of the optimized conformers has been compared. In spite of an apparent structural dissimilarity, a good analogy has been found between the calculated isopotential map of diazoxide and that of at least one selected low energy conformer of pinacidil. It has been suggested that, unlike cromakalim, the low but observable activity of pinacidil on pancreatic B-cells could be explained by adoption for this compound of a conformation having a diazoxide-like stereoelectronical imprint which could assume a similar interaction on the same biological receptor. [less ▲]

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See detail7-Methyl-3-methylthio-4H-pyrido[4,3-e]-1,2,4-thiadiazin-7-ium-4-ide 1,1-dioxide zwitterion
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailAnalyse critique de l'utilisation d'un appareil isocinétique
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Journal de Traumatologie du Sport (1995), 12

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See detailProposition Of A 3-Dimensional Representation Of The Constitutive Protein Of The Hepatitis-B Surface-Antigen Particles
Sonveaux, N.; Ruysschaert, Jm.; Brasseur, Robert ULg

in Journal of Protein Chemistry (1995), 14(6), 477-86

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle ... [more ▼]

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle membrane could provide helpful information for replacing surface-exposed protein domains by foreign sequences without destabilizing the particle structure. Since the crystallization of the protein in its lipid environment remains inaccessible in the near future, alternative approaches had to be envisaged. We combine here the available experimental structural and topological data with a conformational procedure to identify membrane-associated domains of the HBsAg protein and to propose a three-dimensional description of their assembly within the particle membrane. The proposed protein structure is composed of four membrane-spanning helices and an amphipatic helix located on the inner surface membrane. The transmembrane helices are assembled into a highly hydrophobic complex in which no access to the water environment is allowed. The approach could be extended to other membrane-associated proteins. [less ▲]

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See detailGrowth hormone-binding protein (GHBP) binds prolactine in cattle plasma
Massart, Serge; Ban, Anna-Maria; Renaville, Robert ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995), 103

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See detail3,7-Dimethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide zwitterion
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailComparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone.
Roux, C.; Gennari, C.; Farrerons, J. et al

in Arthritis and Rheumatism (1995), 38(6), 851-8

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with ... [more ▼]

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with radiologic lesions characteristic of Paget's disease of bone and serum alkaline phosphatase (AP) concentrations at least twice the upper limit of normal, in a prospective, randomized, double-blind, multicenter clinical trial lasting 6 months. Patients were randomly allocated into 1 of 3 treatment groups: tiludronate for 3 months followed by placebo for 3 months, tiludronate for 6 months, or etidronate for 6 months. Serum AP levels and urinary hydroxyproline excretion were measured at baseline and after 3 months and 6 months. Patients with a reduction of at least 50% in the serum AP concentration were considered to be responders. RESULTS: After 3 months, the proportion of responders was higher in the tiludronate group (57.4%) than in the etidronate group (13.9%) (P < 0.0001). In the etidronate group, this percentage was lower among patients who had received previous treatment with a bisphosphonate (2.3%) than among those who had not (28.6%) (P < 0.01). Previous bisphosphonate treatment was not associated with response in the tiludronate group. After 6 months, the proportion of responders did not differ between the 2 tiludronate groups (60.3% and 70.1%), but was lower in the etidronate group (25.3%) (P < 0.0001). There was a higher proportion of patients with treatment-resistant disease (< 25% reduction of serum AP) in the etidronate group (51.9%) than in the tiludronate 3-month group (17.9%) or the tiludronate 6-month group (19.5%) (P < 0.0001). Gastrointestinal disturbances were more common, and occurred earlier, with tiludronate, but they were mostly mild, requiring no treatment. CONCLUSION: Tiludronate at 400 mg/day for 3 months or 6 months is more effective than the same dosage of etidronate for 6 months in the treatment of Paget's disease. [less ▲]

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See detailSynthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics
Masereel, B.; Dupont, L.; Laeckmann, D. et al

in European Journal of Medicinal Chemistry (1995), 30

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See detailCD4+ T cells determine the ability of spleen cells from F1 hybrid mice to induce neonatal tolerance to alloantigens and autoimmunity in parental mice
Gonzales, M.; Schurmans, Stéphane ULg; Ramos, A. et al

in European Journal of Immunology (1995), 25

Spleen cells from F1 hybrid mice injected into newborn parental mice induce a state of cytolytic unresponsiveness to the corresponding alloantigens. However, these mice develop a transient autoimmune ... [more ▼]

Spleen cells from F1 hybrid mice injected into newborn parental mice induce a state of cytolytic unresponsiveness to the corresponding alloantigens. However, these mice develop a transient autoimmune syndrome characterized by the production of multiple autoantibodies and glomerulonephritis. Previous reports indicated that the depletion of F1 donor T cells, shortly prior the injection into parental mice, does not interfere with any of these events. Here, we have explored whether the continuous absence of T cells in F1 mice influences the ability of their spleen cells to induce neonatal tolerance to alloantigens and the associated autoimmune manifestations. Our results revealed that spleen cells from athymic (BALB/c x C57BL/6) F1 hybrid (CB6F1) nu/nu mice or from euthymic CB6F1 mice depleted from birth of CD4+ T cells, but not of CD8+ T cells, are unable to induce neonatal tolerance to alloantigens and autoimmune manifestations. By contrast, the partial reconstitution of T cells in CB6F1 nu/nu mice, after the neonatal graft of a syngeneic thymus, restored the capacity of spleen cells from these mice to induce tolerance and autoimmunity when injected into newborn BALB/c mice. These results demonstrate that the functional defect of spleen cells from athymic CB6F1 nu/nu mice to induce neonatal tolerance to alloantigens is directly related to the long-term absence of mature CD4+ T cells. Interestingly, a new increase in the titers of anti-DNA Ab was observed when spleen cells from athymic CB6F1 nu/nu mice were injected into adult BALB/c mice that had been tolerized at birth with normal CB6F1 spleen cells. This finding indicates that B cells from CB6F1 nu/nu mice recover their capacity to interact with alloreactive Th2 cells when they are placed into mice having functional CD4+ T cells. These data indicate that the continuous absence of CD4+ T cells causes a reversible functional defect in F1 spleen cells that determines their inability to induce neonatal tolerance and autoimmunity [less ▲]

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See detailOxygen transfert during Bacillus subtilis fermentation. Influence of lipopeptide production and an oxygen vector.
Hbid, Ch; Jacques, Ph.; Meurice, E. et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103(B44),

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See detail2,4,7-Trimethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazinium 1,1-dioxide iodide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailThe Dissociative Ionization of C2H2. The C+, C2+ and CH2+ Dissociation Channels. The Vinylidene Ion as a Transient?
Locht, Robert ULg; Davister, M.

in Chemical Physics (1995), 195

The dissociative electroionization of C2H2 has been investigated in the C+, C2+ and CH2+ dissociation channels. Both the translational energy and the appearance energies have been measured. The kinetic ... [more ▼]

The dissociative electroionization of C2H2 has been investigated in the C+, C2+ and CH2+ dissociation channels. Both the translational energy and the appearance energies have been measured. The kinetic energy versus appearance energy diagrams related to these species are discussed in detail and dissociation mechanisms are proposed for all observed onset energies. For the three ionic species, the dissociation pathways leading to the fragmentation of C2H2+ into C+, C2+ and CH2+ successively have to run very likely over an isomerization mechanism of the molecular ion. The isomeric vinylidene structure could be the most probable intermediate. [less ▲]

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See detailEndogenous nitric oxide modulates acetylcholine-induced edema and vasoconstriction in isolated perfused rabbit lungs.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Journal of Pharmacology and Experimental Therapeutics (The) (1995), 274(2), 559-97

The modulatory role of endogenous nitric oxide (NO) on pulmonary edema induced by acetylcholine (ACh), capsaicin, substance P (SP) and 5-hydroxytryptamine (5-HT) was investigated by using an inhibitor of ... [more ▼]

The modulatory role of endogenous nitric oxide (NO) on pulmonary edema induced by acetylcholine (ACh), capsaicin, substance P (SP) and 5-hydroxytryptamine (5-HT) was investigated by using an inhibitor of NO synthase, N-omega-nitro-L-arginine (L-NNA). The effects of endogenous NO on the hemodynamic response to ACh, 5-HT and SP were also investigated. The capillary filtration coefficient (Kf,c), the total pressure gradient (delta Pt) and its four components [arterial (delta Pa), pre- (delta Pa') and post-capillary (delta Pv'), and venous gradient (delta Pv)] were evaluated on isolated, ventilated, perfused rabbit lungs. ACh (10(-8) to 10(-4) M) and SP (10(-10) to 10(-6) M) induced a concentration-dependent increase in the Kf,c. Capsaicin (10(-4) M) and 5-HT (10(-4) M) also increased this parameter. L-NNA (10(-4) M) completely inhibited the effects of ACh and capsaicin on the Kf,c, without preventing the effects of SP and 5-HT. ACh induced a concentration-dependent vasoconstriction in the precapillary segment. Pretreatment with L-NNA enhanced this increase in delta Pa' but also increased delta Pv' and delta Pv. 5-HT increased delta Pt and delta Pa proportionally to the concentration. This effect was enhanced by L-NNA, which also increased delta Pa'. SP had no significant hemodynamic effect. Pretreatment with L-NNA did not modify the response to SP. Sodium nitroprusside (10(-5) M) induced a left shift of the concentration-response curve to ACh on the Kf,c, although it did not change the response to SP. Sodium nitroprusside also inhibited the hemodynamic effect of ACh. It was concluded that endogenous NO is involved in ACh-and capsaicin-induced edema via a prejunctional stimulatory effect on the C-fibers. Endogenous NO can also modulate ACh- and 5-HT-induced vasoconstriction by exerting a vasodilator action on the whole pulmonary vascular bed. [less ▲]

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See detailContribution de la chimie macromoléculaire à l'élaboration de matériaux colloïdaux et microparticulaires destinés à la vectorisation de médicaments
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Innovation et Technologies en Biologie et en Médecine (1995), 16

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological ... [more ▼]

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological target. The aim of the paper is to give some insight about the contribution of the macromolecular engineering for the development of two vectors : microparticles of a control biodegradation rate designed for the chemoembolization of hepatocarcinoma , amphiphile copolymeric micelles able to transport drug within the targeted cells. Starting from a synthetic polymer : polylactide, degradation rate caracteristics , and functionalities can be tailored for the intended applications. One of the major problems , and largely underestimated in the past , for the successfull design of polymeric carrier is to take into account the interaction of proteins with polymer surfaces. [less ▲]

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See detailStudy of residual water types in freeze-dried Lactobacillus acidophilus by nuclear magnetic resonance
Hodzic, D.; Llabres, Gabriel ULg; Zgoulli, S. et al

in Lebensmittel-Wissenschaft & -Technologie = Food Science & Technology (1995), 28

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See detailAcetic acid esters synthesis catalysed by Candida antarctica lipase.
Fonteyn, Fabienne ULg; Lognay, Georges ULg; Marlier, M.

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30(3), 183-188

Synthesis of various acetates catalysed by the Candida antarctica SP435 lipase was carried out in n-heptane. Reactions progress was established over a one hour period. Differences appeared in function of ... [more ▼]

Synthesis of various acetates catalysed by the Candida antarctica SP435 lipase was carried out in n-heptane. Reactions progress was established over a one hour period. Differences appeared in function of the structure and the chain length of alcohols: linalool and menthol were not esterified whereas the esterification of 1-dodecanol gave the highest rate (474 micromole per min and per g) and yield (86 per cent). [less ▲]

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See detailMediators in critical illness
Deby, Ginette ULg; Lamy, Maurice ULg

in Current Anaesthesia and Critical Care (1995), 6(1), 3-9

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See detailMechanisms of substance P-induced pulmonary oedema in the rabbit: interactions between parasympathetic and excitatory NANC nerves.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Fundamental & Clinical Pharmacology (1995), 9(5), 450-7

The pharmacological mechanisms involved in the substance P (SP)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. Substance P induced a dose-dependent increase in the capillary ... [more ▼]

The pharmacological mechanisms involved in the substance P (SP)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. Substance P induced a dose-dependent increase in the capillary filtration coefficient (Kf,c), responsible for oedema. Atropine, hemicholinium-3 and ruthenium red pretreatment partly protected the lungs against SP effects, while tetrodotoxin and hexamethonium did not significantly modify them. (+/-)CP96,345, a NK1 receptor antagonist, completely inhibited the SP-induced increase in the Kf,c. Like SP, acetylcholine (ACh) and capsaicin also increased the Kf,c. Atropine and (+/-)CP96,345 completely blocked the oedema induced by both drugs. Tetrodotoxin and ruthenium red strongly inhibited the response to capsaicin and acetylcholine. It was concluded that SP-induced pulmonary oedema is in part mediated by a stimulating action on cholinergic efferent nerves, with subsequent release of endogenous acetylcholine. Acetylcholine can, in turn, stimulate the release of SP from excitatory non adrenergic, non cholinergic nerves. The effects induced by capsaicin and exogenous acetylcholine, thus endogenous SP, involve tetrodotoxin-sensitive mechanisms, while those produced by exogenous SP are tetrodotoxin-resistant. [less ▲]

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See detailTreatment of Clostridium difficile colitis. Summary of a round table held in Brussels on March, 3rd, 1994.
Delmée, Michel; Melin, Pierrette ULg; Peetermans, Willy et al

in Acta Clinica Belgica (1995), 50(2), 114-6

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea ... [more ▼]

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea with metronidazole while maintaining the use of oral vancomycin in serious or life-threatening colitis. Clostridium difficile is a common cause of diarrhoea after antibiotic therapy and induces a spectrum of diseases ranging from mild diarrhoea to pseudomembranous colitis (PMC). It is considered to be the first cause of diarrhoea occurring among hospitalized patients (1). [less ▲]

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See detailAvoided resonance overlapping beyond the energy independent formalism. I. Vibrational predissociation
Desouter, Michèle ULg; Liévin, Jacques; Brems, Vincent

in Journal of Chemical Physics (1995), 103

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See detailTrente cinq années de programmes d'histoire dans l'enseignement secondaire francophone
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1995), 45e année(n°3), 1-6

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See detailCharacterization and partial amino acid sequencing of a 107-kDa procollagen I N-proteinase purified by affinity chromatography on immobilized type XIV collagen.
Colige, Alain ULg; Beschin, A.; Samyn, B. et al

in Journal of Biological Chemistry (1995), 270(28), 16724-30

Procollagen I N-proteinase (EC 3.4.24.14), the enzyme that specifically processes type I and type II procollagens to collagen, was isolated from extracts of fetal calf skin. After two chromatographic ... [more ▼]

Procollagen I N-proteinase (EC 3.4.24.14), the enzyme that specifically processes type I and type II procollagens to collagen, was isolated from extracts of fetal calf skin. After two chromatographic steps on concanavalin A-Sepharose and heparin-Sepharose, the semi-purified preparation was used to produce monoclonal antibodies. One reacting antibody was found to recognize not the enzyme itself but type XIV collagen on which the enzyme was bound. This binding, highly sensitive to ionic conditions (plH, salt concentrations) but not affected by non-ionic detergents, was used for affinity chromatography that strongly improved the purification procedure. The enzyme is extensively characterized: 1) it has a molecular mass of 107 kDa as determined by polyacrylamide gel electrophoresis in presence of SDS and of about 130 kDa when estimated by gel filtration on a Sephacryl-S300; 2) in standard assay (pH 7.5, 0.2 M NaCl, 35 degrees C), the activation energy for reaction with amino procollagen type I was 17,000 calories per mole. In the same conditions, Km and Vmax values were, respectively, 435 and 39 nM per hour but varied strongly with pH and salt concentration; 3) the enzyme cleaved the NH2-terminal propeptide of type I procollagen at the specific site, the Pro-Gln bond in the alpha 1 type I procollagen chain; 4) the enzyme contained a high proportion of Gly, Asx, and Glx residues but no Hyp or Hyl; 5) partial amino acid sequences obtained from internal peptides of the enzyme displayed no significant homology with known sequences. The association of procollagen I N-proteinase with a FACIT (fibril-associated collagens with interrupted triple helices) collagen as found here might be of physiological significance. [less ▲]

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See detailStructure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.
De Backer, O.; Verheyden, A. M.; Martin, B. et al

in Genomics (1995), 28(1), 74-83

The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of ... [more ▼]

The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of various histological types but not in normal tissues except testis. The MAGE genes are arranged in two groups that are located within two different regions of the human X chromosome (Xq26-qter and Xp21.3). By hybridizing mouse genomic libraries with a MAGE1 probe, we identified three homologous genes. Two of these mouse genes, Smage1 and Smage2, are more than 99% identical to each other and encode the same protein of 330 aa. The 5' noncoding region of Smage2 provides the potential for regulating the expression of the gene through several different promoters located in front of alternative first exons. The third gene, Smage3, has the structure of a processed transcript. It codes for a protein with only 11 aa substitutions with respect to the Smage1/2 product. Somatic cell hybrids and interspecific backcross analysis showed that Smage3 is autosomal and that Smage1 and Smage2 are located between the Dmd and the Ar loci on the mouse X chromosome. Since this region is syntenic to the human Xp21.1-p22.1 region, we conclude that Smage1 and Smage2 are homologous to the MAGE-Xp rather than to the MAGE-Xq genes. Smage1/2 transcripts were detected in several tumor and embryonal cell lines but not in normal mouse tissues with the exception of testis. Expression of Smage3 was found in embryos from Day 11 to Day 15. [less ▲]

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See detail3-Methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detail24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
Sturis, J.; Scheen, André ULg; Leproult, R. et al

in Journal of Clinical Investigation (1995), 95(4), 1464-71

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in ... [more ▼]

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine normal young men were each studied on two occasions during a 28-h period including a period of polygraphically recorded sleep. Endogenous insulin secretion was suppressed by somatostatin, a constant intravenous glucose infusion was administered, and exogenous insulin was infused either at a constant rate or in a sinusoidal pattern with a period of 120 min. The mean glucose level over the 28-h period was 0.72 +/- 0.31 mmol/liter lower when insulin was infused in an oscillatory pattern than when the rate of infusion was constant (P < 0.05). The greater hypoglycemic effect of oscillatory versus constant infusion was particularly marked during the daytime, with the difference averaging 1.04 +/- 0.38 mmol/liter (P < 0.03). Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both conditions. Ultradian insulin oscillations appear to promote more efficient glucose utilization. [less ▲]

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See detailHemodynamic effects of intratracheal administration of Pasteurella haemolytica in calves
Amory, Hélène ULg; Linden, Annick ULg; Desmecht, Daniel ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailWest Gondwanan aspects of the Middle and Upper Devonian Miospore Zonation in North Africa and Brazil.
Loboziak, S; Streel, Maurice ULg

in Review of Palaeobotany and Palynology (1995), 86

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See detailDynamic generalized linear models and repeated measurements
Lindsey, James ULg; Lambert, Philippe ULg

in Journal of Statistical Planning & Inference (1995), 47

The dynamic generalized linear model for non-normal data is extended for use in repeated measurements, when series of observations are available for more than one individual. Examples are given for count ... [more ▼]

The dynamic generalized linear model for non-normal data is extended for use in repeated measurements, when series of observations are available for more than one individual. Examples are given for count and duration data. [less ▲]

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See detailRecherche expérimentale sur le comportement au feu des colonnes en béton armé
Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg; Baus, Raymond et al

in Annales de l'Institut Technique du Bâtiment et des Travaux Publics [=AIBTP] (1995), 539(254), 25-41

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See detailDecomposing efficiency into its managerial and its regulatory components: The case of European railways
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in European Journal of Operational Research (1995), 80

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See detailEnergy levels of High l - States in Neutral and Singly Ionized Argon
Palmeri, P.; Biémont, Emile ULg

in Physica Scripta (1995), 51

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See detailHelix Helix Interactions In Reconstituted High-Density-Lipoproteins
Lins, Laurence ULg; Brasseur, Robert ULg; De Pauw, Mc. et al

in Biochimica et Biophysica Acta-Lipids and Lipid Metabolism (1995), 1258(1), 10-8

In this work we calculated the ionic interactions between adjacent amphipathic helices of apo A-I and apo A-IV. The calculation of the electrostatic potential around the helices helps identify the charged ... [more ▼]

In this work we calculated the ionic interactions between adjacent amphipathic helices of apo A-I and apo A-IV. The calculation of the electrostatic potential around the helices helps identify the charged residues susceptible to form salt bridges between adjacent helices. An estimation of the stability of the different pairs of helices is derived from the calculation of the energy of interaction between contiguous helices at a water/lipid interface after energy minimization. The most stable energetic conformation corresponds to the 17-residue helices oriented anti-parallel and separated by a stretch of 5 residues in an extended beta-strand conformation, as calculated through the 'stereo alphabet' calculation procedure. In a pair of helices, the hydrophobic faces are directed towards the lipid core of the discoidal phospholipid-apolipoprotein complex and the hydrophobic lipid-protein interactions are major determinants for the stability of the complex. Interactions between polar residues located on the opposite face of the helix and water molecules can also contribute to the overall energy of the system. Finally, salt bridge formation between residues of opposite charge along the edge of the helical segments contribute to the cooperativity of the phospholipid-apolipoprotein complex formation. The mode of assembly of the amphipathic helical repeats of the apolipoproteins around the edge of a discoidal complex is therefore determined both by the hydrophobic character of the residues and by the charge complementarity along the edge of the helices which increases the structural stability and determines the relative orientation of the helices. [less ▲]

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See detailIntérêt du calcul du rapport Trough/Peak (effet en fin de dose/effet maximum) lors d'un traitement antihypertenseur
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Médecine et Hygiène (1995), 53

Un rapport entre l'effet antihypertenseur résiduel (à la fin de l'intervalle entre deux prises) et l'effet au pic d'efficacité (TroughlPeak) constitue un index arithmétique utile pour apprécier l ... [more ▼]

Un rapport entre l'effet antihypertenseur résiduel (à la fin de l'intervalle entre deux prises) et l'effet au pic d'efficacité (TroughlPeak) constitue un index arithmétique utile pour apprécier l'efficacité antihypertensive pour la fréquence d'administration proposée après soustraction de l'effet placebo. Un rapport inférieur à 50% indique que la molécule doit être administrée soit à posologie plus élevée, soit plus fréquemment. A l'inverse, un rapport approchant les 100% indique que l'effet antihypertenseur est maintenu de façon homogène pendant tout l'intervalle considéré, intéressant chez les sujets peu compliants. Il existe cependant une variabilité individuelle importante de la réponse antihypertensive traduite par la dispersion des valeurs autour de la moyenne de ce rapport TroughlPeak (TIP). Quoi qu'il en soit, il reste à démontrer que le calcul de ce rapport TIP est utile en pratique, notamment par l'objectivation d'une relation entre sa valeur et la prévention des phénomènes de morbidité et de mortalité cardio-vasculaires. [less ▲]

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See detailNotice sur Marcel Migeotte
Biémont, Emile ULg

in Annuaire de l'Académie Royale de Belgique (1995)

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See detailRecent advances in ring-opening polymerization of lactones and related compounds
Lögfren, Anders; Albertsson, Ann-Christine; Dubois, Philippe ULg et al

in Journal of Macromolecular Science - Reviews in Macromolecular Chemistry and Physics (1995), C35(3), 379-418

Polyesters are currently synthesized by a step-growth mechanism from a mixture of a diol and a diacid (or a diacid derivative), or from a hydroxy-acid when available. Ring-opening polymerization (ROP) of ... [more ▼]

Polyesters are currently synthesized by a step-growth mechanism from a mixture of a diol and a diacid (or a diacid derivative), or from a hydroxy-acid when available. Ring-opening polymerization (ROP) of lactones and related compounds is an alternative method for the synthesis of aliphatic polyesters. Comparison of these two mechanisms is clearly in favor of the polyaddition process. The drawbacks of polycondensation are well known:high temperatures and long reaction times are required to produce high-molecular-weight chains. Even though conversion of the hydroxyl and acid group is close to completion, any departure from the reaction stoichiometry has a very detrimental effect on the chain length. [less ▲]

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See detailClinical neurophysiology and neurotransmitters
MAERTENS DE NOORDHOUT, Alain ULg; Wang, Wei; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1995), 15(4), 301-9

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional ... [more ▼]

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional evaluation of neurotransmission at the neuromuscular junction, in some spinal interneurons and intracortical circuits as well as evaluation of pharmacological modulation of some electrophysiological tests. These investigations are carried out to help our understanding of the pathophysiology of brain diseases. Finally, we discuss possible relationships between electrophysiological tests (evoked/event-related potentials and exteroceptive suppression of temporalis muscle activity) and neurotransmitter function in headache. [less ▲]

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See detailNF-kappaB transcription factor and human immunodeficiency virus type 1 (HIV-1) are activated by methylene blue photosensitization
Piret, Bernard; Legrand-Poels, Sylvie ULg; Sappey, Christine et al

in European Journal of Biochemistry (1995)

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See detailLe risque familial de l'anévrisme de l'aorte abdominale et ses conséquences pour l'organisation d'un dépistage sélectif
Limet, Raymond ULg

in Journal des Maladies Vasculaires (1995), 20(4), 285-7

Aneurysm of the abdominal aorta (AAA) is multifactorial disease related to acquired factors (arteriosclerosis) and genetic factors (collagen anomalies) with, in some cases, a familial component. The ... [more ▼]

Aneurysm of the abdominal aorta (AAA) is multifactorial disease related to acquired factors (arteriosclerosis) and genetic factors (collagen anomalies) with, in some cases, a familial component. The incidence of familial AAA was evaluated in 324 patients in 313 families who underwent surgery for AAA. A family survey was used to determine whether members of the operated patients had AAA or had died due to ruptured aneurysms. There were 276 cases (including 12 females) with sporadic AAA and 81 cases (including 5 females) who were members of families with at least one other member having AAA. Comparison between sporadic AAA (SAAA) and familial AAA (FAAA) demonstrated the following differences: 1) diagnosis was made earlier in FAAA (p < 0.05) than in SAAA (64.1 versus 66 years of age respectively), 2) patients with FAAA were younger at the time of rupture (65.4 versus 75.1 years, p < 0.001), 3) the incidence of rupture was greater in FAAA than in SAAA (32.4% versus 8.7% p < 0.001), and finally 4) the relative risk of developing AAA was 18 times greater in members of a family with AAA than in the reference population. Early screening with ultrasonic examinations in at least patient's brother's over 50 years would not be an unjustified expense. The frequency of later examinations would depend on the size of the aorta initially observed. If FAAA is evidenced, under normal conditions, corrective surgery should be proposed earlier than for sporadic AAA. [less ▲]

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See detailFormer par les stages
Jadoulle, Jean-Louis ULg

in Pédagogies. Cahiers du Laboratoire de Pédagogie Expérimentale de l'Université de Louvain (1995), X

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See detailDe ruimtebeleving in Vestdijks Verzamelde verhalen III
Nachtergaele, Lutgarde ULg

in Vestdijkkroniek (1995), 88-89

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See detailIS THE PRESENCE OF MESOTROPHIC PLANT-COMMUNITIES IN THE PEAT-BOGS OF HAUTES-FAGNES (BELGIUM) CONNECTED WITH TONALITE INTRUSIONS IN THE REVINIAN LAYERS
Hambuckers, Alain ULg; Schumacker, René ULg; Remacle, Jean ULg et al

in Belgian Journal of Botany (1995), 128(1), 48-56

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species ... [more ▼]

Within the Hautes-Fagnes Nature Reserve (Belgium) acidic and oligotrophic biotopes are developing on very acidified stony silt raised bogs. However, they are locally dominated by mesotrophic species. Based on the fact that there are several outcrops of tonalite in the region and particularly one in the Nature Reserve, a hypothesis to explain these singularities of the vegetation implies discontinuities of the bedrock provoked by intrusions of this magmatic rock in the Revinian layer covering the region. Seventeen plots containing Phragmites australis were examined and vegetation was described. Silt and soil water were sampled and analyzed for mineral contents in 15 sites. The differences of mineral composition between the P. australis plots and their surrounding environment confirmed the more mesotrophic characteristics of these plots (i.e. higher pH, higher Ca and Mg contents, lower Al content). However, the lower Zn, Pb and Fe contents would lead to reject the hypothesis of intrusions of tonalite since these elements are more abundant in the tonalite and its mineralization than in the Revinian rock. Nevertheless, the overall ecological conditions of the examined plots and the differences of plant species composition suggested that the observed chemical environment could be evoked for explaining the distribution of the mesotrophic species in the oligotrophic environment of the Nature Reserve. Consequently, an alternative hypothesis is proposed. [less ▲]

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See detailHypnosis as adjunct therapy in conscious sedation for plastic surgery
Faymonville, Marie ULg; Fissette, Jean ULg; Mambourg, P.-H. et al

in Regional Anesthesia (1995), 20(2), 145-151

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See detailUn autre regard sur les atlas de France et de Belgique.
Vansteenwegen, Christian; Dufrêne, Marc ULg; Lebrun, Philippe

in AVES (1995), 31

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See detailLa thermographie infrarouge dans l'étude de la thermorégulation : revue de la littérature
Spruyt, P.; Ghafir, Y.; Art, Tatiana ULg et al

in Annales de Médecine Vétérinaire (1995), 139

Infrared thermography is a method to assess the skin temperature by means of a camera equipped with an infrared detector. It makes thermograms that represents the surface temperature of skin patterns ... [more ▼]

Infrared thermography is a method to assess the skin temperature by means of a camera equipped with an infrared detector. It makes thermograms that represents the surface temperature of skin patterns. This article summerizes the different information about thermography and thermoregulation of horses. In fact, lots of information exist about thermoregulation of most of the domestic animais but very little exists as far as horses are concerned. Two different types of devices are used for thermography : contacting and noncontacting which measure the infrared radiation either with a thermometer or with a themographic camera. The blood circulation dictates the thermic model which is at the origin of thermographic interpretation. This latter is a good method helping to study thermoregulation. [less ▲]

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See detailFeed restriction and IGFBP in bulls: effects of increasing starving period lengths.
Massart, Serge; Van Eenaeme, Christian ULg; Renaville, Robert ULg et al

in Journal of Animal Science (1995), 73(suppl 1), 225

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See detailAnalysis of the open reading frames of the main capsid proteins of actinophage VWB.
Anne, J; Fiten, P; Van Mellaert, L et al

in Archives of Virology (1995), 140(6), 1033-47

The nucleotide sequence of a 6 kb fragment encoding the main late proteins (p14, p38 and p24) of actinophage VWB was obtained. Sequence comparison of the encoded proteins with those filed in databases ... [more ▼]

The nucleotide sequence of a 6 kb fragment encoding the main late proteins (p14, p38 and p24) of actinophage VWB was obtained. Sequence comparison of the encoded proteins with those filed in databases indicated that the phage VWB main late proteins were all novel. A search for special motifs revealed that p14 (13.3 kDa) has a P-loop sequence commonly found in ATP- and GTP-binding proteins. This observation might indicate that p14 is important for ATP-driven DNA translocation during encapsidation of VWB phage DNA into the phage head. Furthermore, the polypeptide ORF2 (26.9 kDa) has an unusual primary structure consisting of 3 stretches of acidic amino acid residues and a glycine/arginine rich C-terminal end. From comparison with other proteins including the bacteriophage T4 prohead core component and from the data of special motif analysis the ORF2 gene product is probably involved in prohead core formation. [less ▲]

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See detailContrôle du phytoplancton du bassin ligure par le front liguro-provençal (secteur corse)
Goffart, Anne ULg; Hecq, Jean-Henri ULg; Prieur, Louis

in Oceanologica Acta (1995), 18

The evolution of the phytoplankton distribution was followed along the Calvi - Nice axis, from Calvi to 30 miles offshore, in relation with the hydrological features of the Liguro-Provençal front ... [more ▼]

The evolution of the phytoplankton distribution was followed along the Calvi - Nice axis, from Calvi to 30 miles offshore, in relation with the hydrological features of the Liguro-Provençal front (Corsican sector) and the nutrients disponibility. Oceanographic cruises repeated between 1982 and 1991 have emphasized the permanence of the front and the interannual stability of its hydrological characteristics. Moreover, the front and the associated vertical circulation influenced highly, and in a reproducible way, the algal distribution within distances of few kilometres. In March, within the Ligurian current (on the coastal side), the front and the central zone (on the open sea side), stabilization of upper layers of water column, induced by a beginning of vertical stratification, is the main factor controlling the starting of the bloom. As soon as phytoplankton development is initiated, highest values of chlorophyll a and primary production are observed in the frontal area. During spring, a significant amount of the phytoplankton produced in the surface layer was carried down along the isopycnals in relation with the frontal convergence. As a consequence, the chlorophyll a distribution was typically like a plume, extending from the surface to at least 100 m deep. In all zones, during the stratified period, the position of the chlorophyll a maximum in the water column is determined by the opposing gradients of light and nitrate. In May, the maximum of phytoplankton was permanently observed in the frontal area where it was strictly correlated with the nitracline. A sharp core of high chlorophyll a concentrations was also observed in the central zone while the Ligurian current was characterized by very low pigment levels. During that period, the ecological role of the front seems to be particularly important because it delimits the unique area of enhanced phytoplanktonic biomass in an oligotrophic or very oligotrophic environment. In June, a well-developed deep chlorophyll a maximum was observed everywhere, from the central zone to the coast. The contribution of the front to the enhancement of the biomass appears to be less important than during spring. [less ▲]

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See detailLocalization and transmembrane topology of a new member of the mitochondrial carrier family, the yeast RIM 2 gene product
El Moualij, B.; Duyckaerts, Claire ULg; Lamotte-Brasseur, J. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995)

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See detailEffect of risedronate on collagen cross-links in postmenopausal osteoporosis
Zegels, Brigitte ULg; Balena, R; Eastell, R et al

in Journal of Bone and Mineral Research (1995), 10(s1), 455

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See detailEffects of infused sodium lactate on glucose and energy metabolism in healthy humans.
Paquot, Nicolas ULg; Schneiter, P.; Cayeux, M. C. et al

in Diabètes & Métabolism (1995), 21(5), 345-52

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg ... [more ▼]

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg-1.min-1) euglycaemic clamp. Glucose rate of appearance (GRa) and disappearance (GRd) were measured from plasma dilution of infused U- 13C glucose, and glucose oxidation (G(ox)) from breath 13CO2 and plasma 13C glucose. In basal conditions, lactate infusion did not alter G(ox) (8.8 +/- 0.9 vs 9.2 +/- 1.1 mumol.kg-1.min-1), while GRa slightly decreased from 15.2 +/- 0.8 basal to 13.9 +/- 0.9 mumol.kg-1.min-1 after lactate (p < 0.05). During a hyperinsulinaemic clamp, hepatic glucose production was completely suppressed with or without lactate. Lactate decreased G(ox) from 17.1 +/- 0.4 to 13.4 +/- 1.2 mumol.kg-1.min-1 (p < 0.05), whereas GRd was unchanged (39.7 +/- 3.6 vs 45.6 +/- 2.6 mumol.kg-1.min-1. It is concluded that infusion of lactate in basal conditions does not increase GRa or interfere with peripheral glucose oxidation, and that during hyperinsulinaemia lactate decreases glucose oxidation but does not alter hepatic or peripheral insulin sensitivity. [less ▲]

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See detailMolecular biology in support of an old paradigm about the induction of flowering
Périlleux, Claire ULg

in Flowering Newsletter (1995), 20

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See detailA experiência Pedagógica «Renovação do Ensino Elementar - Desenvolvimento Corporal das Crianças dos 2,5 Anos aos 12 Anos»
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Boletim Sociedade Portuguesa de Educação Física (1995), 12(2), 31-58

This paper presents the methodology and main results of a research program aiming to identify the effect of a daily physical education project implemented in the French speaking part of Belgium.

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See detailGlucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies.
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1995), 19 Suppl 3

Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for ... [more ▼]

Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for insulin resistance by peripheral hyperinsulinism, the latter resulting from both increased insulin secretion and reduced insulin clearance. Impaired glucose tolerance is observed when insulin resistance is associated to impaired first-phase insulin response, which results in a significant increase in plasma glucose levels and a late insulin hyperresponsiveness. Both hyperinsulinaemia and hyperglycaemia are then able to overcome peripheral insulin resistance and impaired glucose disposal. When a more marked defect in insulin secretion is present, hyperglycaemia progresses, probably due to an additional participation of impaired suppression of hepatic glucose output. Overt diabetes then occurs with persistent post-absorptive hyperglycaemia. All these abnormalities can be reversed after a marked weight loss and recovery of ideal body weight, arguing for acquired rather than inherited metabolic defects in presence of morbid obesity. If a sufficient weight reduction can not be obtained, pharmacological approaches may be considered to improve insulin resistance of obese subjects, especially those with impaired glucose tolerance or overt diabetes. [less ▲]

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See detailInfluence du risque suicidaire et du desespoir sur l'amplitude de l'onde P300 dans la depression majeure.
Urcelay-Zaldua, I.; Hansenne, Michel ULg; Ansseau, Marc ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (1995), 25(5), 291-6

P300 amplitude represents a useful tool to assess information processing in normal and psychopathological subjects. In depressive disorders, many studies have shown a decrease of P300 amplitude and an ... [more ▼]

P300 amplitude represents a useful tool to assess information processing in normal and psychopathological subjects. In depressive disorders, many studies have shown a decrease of P300 amplitude and an increase of its latency. However, functional significance of the P300 modifications remain unclear. The aim of the study was to assess the influence of suicidal risk and hopelessness on P300 amplitude among 40 depressive inpatients. The results showed significant relationships between P300 amplitude and suicidal risk (r = -0.68, p < 0.001) and with hopelessness (r = -0.76, p < 0.001). From a clinical point of view, P300 amplitude should be considered as a psychophysiological index of suicidal risk in major depressive disorder. [less ▲]

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See detailApplication of sucrose synthase from rice grains for the synthesis of carbohydrates.
Elling, Lothar; Grothus, Marita; Zervosen, Astrid ULg et al

in Annals of the New York Academy of Sciences (1995), 750

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are ... [more ▼]

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are required as substrates for glycosyltransferases. Activated sugars are usually synthesized by pyrophosphorylases from nucleoside triphosphates and sugar-l-phosphates.'.* For cyclic in situ regeneration, at least three enzymes are needed, which makes the synthesis of, for example, N-acetyllactosamine very complex by established procedure. We report here on the enzymatic synthesis of saccharides and activated sugars by the plant glycosyltransferase sucrose synthase (EC 2.4.1.13)! The glycosyltransferase has the unique feature of catalyzing in vitro the synthesis and cleavage of sucrose (SCHEME1 ). The main advantage of sucrose synthase over pyrophosphorylases is the utilization of nucleoside diphosphates (NDP) instead of nucleoside triphosphates to generate activated sugars. [less ▲]

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See detailSU (3) scaled effective lagrangians for a hot and strange system
Jaminon, Martine ULg; Van Den Bossche, Bruno

in Nuclear Physics A (1995), 582

We construct two effective lagrangians which reproduce the explicit flavor SU(3) symmetry breaking and the trace and axial anomalies of QCD. All analytical expressions are derived for a hot strange matter ... [more ▼]

We construct two effective lagrangians which reproduce the explicit flavor SU(3) symmetry breaking and the trace and axial anomalies of QCD. All analytical expressions are derived for a hot strange matter but the results are only shown for zero baryonic density. We study the coupling of the quark condensates (u and s) to the gluon condensate. We also consider the temperature behavior of the pion and of the kaon masses. We show that the results crucially depend on the choice of the two free parameters of the model: the chiral transition can be of first or of second order; the coupling between the gluon and the quark condensates can be large or not; the meson masses can increase or decrease with temperature. The introduction of the QCD trace anomaly in the SU(3) NJL model kills the predictive character of the NJL. [less ▲]

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See detailNimesulide
Dupont, L.; Pirotte, Bernard ULg; Masereel, B. et al

in Acta Crystallographica (1995), C51

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See detailHIV-1 and NF-kappaB activation by photo-oxidative stress
Piette, Jacques ULg; Legrand-Poels, Sylvie ULg; Piret, Bernard

in Photochemistry & Photobiology (1995)

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See detailDiarylazepine derivatives as potent atypical neuroleptic drugs: Recent advances
Liégeois, Jean-François ULg; Bruhwyler, J.; Rogister, F. et al

in Current Medicinal Chemistry (1995), 1

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See detailImmunohistochemical identification of varicella-zoster virus gene 63-encoded protein (IE63) and late (gE) protein on smears and cutaneous biopsies: implications for diagnostic use.
Nikkels, Arjen ULg; Debrus, S.; Sadzot-Delvaux, Catherine ULg et al

in Journal of Medical Virology (1995), 47(4), 342-7

Early and specific recognition of varicella zoster virus (VZV) infection is of vital concern in immunocompromised patients. The aim of this study was to compare the diagnostic accuracy of histochemical ... [more ▼]

Early and specific recognition of varicella zoster virus (VZV) infection is of vital concern in immunocompromised patients. The aim of this study was to compare the diagnostic accuracy of histochemical and immunohistochemical identification of the VZV ORF63 encoded protein (IE63) and of the VZV late protein gE on smears and formalin-fixed paraffin-embedded skin sections taken from lesions clinically diagnosed as varicella (n = 15) and herpes zoster (n = 51). Microscopic examinations of Tzanck smears and skin sections yielded a diagnostic accuracy of Herpesviridae infections in 66.7% (10/15) and 92.3% (12/13) of varicella, and 74.4% (29/39) and 87.8% (43/49) of herpes zoster, respectively. Immunohistochemistry applied to varicella provided a type-specific virus diagnostic accuracy of 86.7% (13/15; IE63) and 100% (15/15; gE) on smears, and of 92.3% for both VZV proteins on skin sections. In herpes zoster, the diagnostic accuracy of immunohistochemistry reached 92.3% (36/39; IE63) and 94.9% (37/39; gE) on smears, and 91.7% (44/48; IE63) and 91.8% (45/49; gE) on skin sections. These findings indicate that the immunohistochemical detection of IE63 and gE on both smears and skin sections yields a higher specificity and sensitivity than standard microscopic assessments. [less ▲]

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See detailAzidothymidine as a potential modifier of radiation-reponse
Copaceanu, M-L; COUCKE, Philippe ULg; Cottin, E et al

in Acta Oncologica (1995)

Abstract The potential effect of AZT as a thymidine analogue on radiation response in vitro was investigated. Two human cell lines (WiDr and HeLa) were used. The effect of 10 μM AZT on exponentially ... [more ▼]

Abstract The potential effect of AZT as a thymidine analogue on radiation response in vitro was investigated. Two human cell lines (WiDr and HeLa) were used. The effect of 10 μM AZT on exponentially growing cells was studied after different exposure times (24, 48 and 72 h). The surviving fraction (clonogenic assay) or metabolic activity (MTT assay) after irradiation of AZT-exposed cells, was compared to unexposed irradiated controls. Flow cytometry was used to assess the cell-cycle effect of pre-exposure of exponentially growing cells to AZT. AZT had a radioprotective effect for all experimental time points as far as WiDr was concerned. For HeLa the effect was significant at 24 h. Cell-cycle analysis showed a significant accumulation in S-phase at 72 h for WiDr. For HeLa there was a significant accumulation in S-phase at 48 h. We conclude that under the reported experimental conditions, AZT as a thymidine analogue seems to reduce the cytotoxic effect of irradiation. [less ▲]

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See detailTransient respiration locomotion decoupling in galloping thoroughbreds
Jolly, Sandra ULg; Art, Tatiana ULg; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1995), 18(suppl), 13-17

The compulsory respiration locomotion coupling may sometimes be broken in healthy galloping horses, leading to a `big respiratory cycle' (BRC). This work is aimed at describing the ventilatory pattern of ... [more ▼]

The compulsory respiration locomotion coupling may sometimes be broken in healthy galloping horses, leading to a `big respiratory cycle' (BRC). This work is aimed at describing the ventilatory pattern of the BRC and at studying the influence of the individual horse, gallop speed and training. Eleven healthy Thoroughbred horses were studied during a 9 week period of incremental training intensity. Instantaneous respiratory airflow, tidal volume, respiratory rate and the 02 and C02 fraction in inspired and expired gases were continuously obtained on a breath-by-breath basis during 4 standardised treadmill exercise tests (SET) performed at 3 week intervals. The inspiratory airflow of the BRC had a bi- or triphasic shape and ils inspiratory time was 1.5-fold longer than that of a normal breath. The expiratory flow was monophasic and lasted 2.5-fold longer than the normal breath. The inspiratory, but not the expiratory peak flows, remained unchanged during the BRC. The inspiratory volume was 2.0-to 1.5-fold higher than normal, according to the gallop speed. Each BRC was followed by a`readjustment cycle' (RC), which allowed the recovery of normal respiration locomotion coupling. The sum of BRC + RC times always equalled the time for 3 normal respiratory cycles. The sum of the inspiratory volumes of BRC and RC was significantly higher than the sum of their expiratory volumes. There was a highly significant effect of horse and of training on the frequency of BRC. Lastly, during the BRC and at least the 4 following respiratory cycles, the end-tidal 02 and CO, fractions were significantly lower and higher respectively. It was hypothesised that this respiratory manoeuvre could result from a negative feedback mechanism providing, at least, transiently either a readjustment of the end expiratory lung volume or an improvement of the pulmonary gas exchange [less ▲]

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See detailGlageon: une coupe du Givetien en Avesnois (France). Sédimentologie, Coraux, géologie régionale, diagenèse
Boulvain, Frédéric ULg; Coen-Aubert, M.; Mansy, J. L. et al

in Bulletin de la Société Belge de Géologie (1995), 103(1-2), 171-203

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See detailLe rôle du plissement disharmonique dans la tectogenèse de l'allochtone ardennais
Mansy, J. L.; Meilliez, F.; Mercier, E. et al

in Bulletin de la Société Géologique de France (1995), 3

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See detailSimulating The Folding Of Small Proteins By Use Of The Local Minimum Energy And The Free Solvation Energy Yields Native-Like Structures
Brasseur, Robert ULg

in Journal of Molecular Graphics (1995), 13(5), 312-22

Assuming that the protein primary sequence contains all information required to fold a protein into its native tertiary structure, we propose a new computational approach to protein folding by ... [more ▼]

Assuming that the protein primary sequence contains all information required to fold a protein into its native tertiary structure, we propose a new computational approach to protein folding by distributing the total energy of the macromolecular system along the torsional axes. We further derive a new semiempirical equation to calculate the total energy of a macromolecular system including its free energy of solvation. The energy of solvation makes an important contribution to the stability of biological structures. The segregation of hydrophilic and hydrophobic domains is essential for the formation of micelles, lipid bilayers, and biological membranes, and it is also important for protein folding. The free energy of solvation consists of two components: one derived from interactions between the atoms of the protein, and the second resulting from interactions between the protein and the solvent. The latter component is expressed as a function of the fractional area of protein atoms accessible to the solvent. The protein-folding procedure described in this article consists of two successive steps: a theoretical transition from an ideal alpha helix to an ideal beta sheet is first imposed on the protein conformation, in order to calculate an initial secondary structure. The most stable secondary structure is built from a combination of the lowest energy structures calculated for each amino acid during this transition. An angular molecular dynamics step is then applied to this secondary structure. In this computational step, the total energy of the system consisting of the sum of the torsional energy, the van der Waals energy, the electrostatic energy, and the solvation energy is minimized. This process yields 3-D structures of minimal total energy that are considered to be the most probable native-like structures for the protein. This method therefore requires no prior hypothesis about either the secondary or the tertiary structure of the protein and restricts the input of data to its sequence. The validity of the results is tested by comparing the crystalline and computed structures of four proteins, i.e., the avian and bovine pancreatic polypeptide (36 residues each), uteroglobin (70 residues), and the calcium-binding protein (75 residues); the C alpha-C alpha maps show significant homologies and the position of secondary structure domains; that of the alpha helices is particularly close. [less ▲]

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See detailOpera Latina : la banque de données de textes latins du L.A.S.L.A. sur CD-ROM
Purnelle, Gérald ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1995)

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See detailLogica en esthetica. Notities bij ‘Het bordeel van Ika Loch’ van Paul van Ostaijen
Spinoy, Erik ULg

in Spiegel der Letteren (1995), 37(2-3), 89-128

This article is an innovative rereading of Van Ostaijen's grotesque story 'Ikla Loch's Brothel', in light of the author's late philosophical views.

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See detailEpithelioid Cell Histiocytoma: A Report of Two Cases
Dezfoulian, Bita ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1995), 190(4), 349-350

Epithelioid cell histiocytoma is a rarely reported tumor derived from factor-XIIIa-positive dermal dendrocytes. Two additional cases are presented including their clinical, histologic and ... [more ▼]

Epithelioid cell histiocytoma is a rarely reported tumor derived from factor-XIIIa-positive dermal dendrocytes. Two additional cases are presented including their clinical, histologic and immunohistochemical features. [less ▲]

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See detailDe réels progrès ont-ils été faits dans le traitement de l'ostéoporose ?
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Franchimont, P

in Medi-Sphere (1995), 39

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See detailLa thrombose veineuse profonde des membres supérieurs. Revue de la littérature. A propos d'un cas de syndrome de Paget-Schrotter
Defraigne, Jean-Olivier ULg; Remy, D.; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(8), 336-46

Un cas de thrombose veineuse profonde (TVP) du membre supérieur survenue dans le contexte d'un effort chez un sujet jeune (syndrome de Paget-Schrötter) est présenté. La TVP des membres supérieurs présente ... [more ▼]

Un cas de thrombose veineuse profonde (TVP) du membre supérieur survenue dans le contexte d'un effort chez un sujet jeune (syndrome de Paget-Schrötter) est présenté. La TVP des membres supérieurs présente des caractéristiques étiologiques et physiopathologiques différentes de celles de la TVP des membres inférieurs. On distingue des phlébites primaires et secondaires. La phlébite primaire survient généralement chez des sujets plus jeunes, et une notion d'effort est fréquemment retrouvée. Les phlébites secondaires s'observent dans différentes circonstances: mise en place de cathéters ou de sonde de pacemaker, affections néoplasiques, troubles de l'hémostase... Certaines controverses thérapeutiques existent, et, notamment, sur la nécessité de recourir ou non à la fibrinolyse et, dans les phlébites d'effort qui rentrent dans un contexte de syndrome du défilé costo-claviculaire, sur l'utilité de proposer un traitement chirurgical, en vue de lever la compression extrinsèque et/ou de reperméabiliser la veine. [less ▲]

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See detailLe cas clinique du mois. Troubles electrolytiques severes dans l'anorexie mentale.
Scheen, André ULg

in Revue Médicale de Liège (1995), 50(1), 16-7

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See detailLes Coléoptères Carabidae (Coleoptera) de la Réserve Naturelle du Pré des Forges à Mirwart
Waeyenbergh, M.; Dufrêne, Marc ULg; Lebrun, Philippe

in Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1995), 131

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See detailEfficacité du piège à fosse pour la collecte d' Hypnoidus riparius (Fabricius) (Coleoptera, Elateridae)
Jeuniaux, C.; Dufrêne, Marc ULg

in Bulletin et Annales de la Société Royale Belge d’Entomologie = Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1995), 131

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See detailLa classification fonctionnelle des dysfonctions de la valvule mitrale selon Carpentier
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 292-4

Pour aborder le traitement chirurgical de la valvule mitrale autrement, c'est-à-dire par une réparation valvulaire comme alternative raisonnable au remplacement sytématique, il faut recourir à une ... [more ▼]

Pour aborder le traitement chirurgical de la valvule mitrale autrement, c'est-à-dire par une réparation valvulaire comme alternative raisonnable au remplacement sytématique, il faut recourir à une classfication fonctionnelle des dysfonctions mitrales. Cette classification, établie par Carpentier (1, 2) regroupe les dysfonctions valvulaire mitrales en trois rubriques : a) le type caractérisé par des mouvements valvulaires normaux, b) le type 2, équivalent au prolapsus valvulaire, c) le type 3, correspondant à la restriction des mouvements valvulaires. Cette approche nouvelle postule, en outre, qu'une affection valvulaire n'est parfaitement définie que lorsqu'on en connaît l'étiologie, les lésions et les dysfonctions. L'utilisation de cette méthode analytique (qui a l'avantage de la simplicité et de la clarté) permet au chirurgien de réparer la valvule mitrale en adaptant à chaque dysfonction une correction appropriée et, par l'application de règles, d'obtenir des résultats reproductibles (3-6). [less ▲]

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See detailTemperature dependence of chlorophyll(ide) spectral shifts and photoactive protochlorophyllide regeneration after flash in etiolated barley leaves
Eullaffroy; Salvetat; Franck, Fabrice ULg et al

in Photochemistry & Photobiology (1995), 62(4), 751-756

Absorbance spectroscopy at 77 K was used to investigate the effect of temperature on in vivo chlorophyllide shifts and photoactive protochlorophyllide regeneration after a saturating flash, which ... [more ▼]

Absorbance spectroscopy at 77 K was used to investigate the effect of temperature on in vivo chlorophyllide shifts and photoactive protochlorophyllide regeneration after a saturating flash, which transformed all protochlorophyllide to chorophyllide. Photoactive protochlorophyllide present in darkness was stable up to 40 degrees C. The rate of Shibata shift and protochlorophyllide regeneration after flash were strongly temperature dependent in the range 0-25 degrees C. At 0 degrees C, the shift was still observed but no regeneration occurred. Only slight effects were observed in the range 25-40 degrees C. At all temperatures, the process of protochlorophyllide regeneration was significantly slower than the Shibata shift. The final chlorophyll shift from 672 to 674 nm was observed up to 40 degrees C. The implication of these results concerning the pigment-protein interactions during the Shibata shift are discussed. [less ▲]

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See detailAvoided overlap between two resonance energies or frequencies. Formation of fast and slow decay modes
Desouter, Michèle ULg; Jacques, Vincent

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

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See detailExtraction d'une canine chez un ours polaire
DUFOUR, Pascale ULg; Balligand, Marc ULg; Pypendop, B. et al

in Annales de Médecine Vétérinaire (1995)

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See detailCloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.
Sheridan, P. L.; Schorpp, M.; Voz, Marianne ULg et al

in Journal of Biological Chemistry (1995), 270(9), 4575-87

We have isolated a human cDNA clone encoding HIP116, a protein that binds to the SPH repeats of the SV40 enhancer and to the TATA/inhibitor region of the human immunodeficiency virus (HIV)-1 promoter. The ... [more ▼]

We have isolated a human cDNA clone encoding HIP116, a protein that binds to the SPH repeats of the SV40 enhancer and to the TATA/inhibitor region of the human immunodeficiency virus (HIV)-1 promoter. The predicted HIP116 protein is related to the yeast SNF2/SWI2 transcription factor and to other members of this extended family and contains seven domains similar to those found in the vaccinia NTP1 ATPase. Interestingly, HIP116 also contains a C3HC4 zinc-binding motif (RING finger) interspersed between the ATPase motifs in an arrangement similar to that found in the yeast RAD5 and RAD16 proteins. The HIP116 amino terminus is unique among the members of this family, and houses a specific DNA-binding domain. Antiserum raised against HIP116 recognizes a 116-kDa nuclear protein in Western blots and specifically supershifts SV40 and HIV-1 protein-DNA complexes in gel shift experiments. The binding site for HIP116 on the SV40 enhancer directly overlaps the site for TEF-1, and like TEF-1, binding of HIP116 to the SV40 enhancer is destroyed by mutations that inhibit SPH enhancer activity in vivo. Purified fractions of HIP116 display strong ATPase activity that is preferentially stimulated by SPH DNA and can be inhibited specifically by antibodies to HIP116. These findings suggest that HIP116 might affect transcription, directly or indirectly, by acting as a DNA binding site-specific ATPase. [less ▲]

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See detailIron chelation decreases NF-kappaB and HIV-1 activation due to oxidative stress
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in AIDS Research and Human Retroviruses (1995)

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See detailThe hydrophobic effect in protein folding.
Lins, Laurence ULg; Brasseur, Robert ULg

in FASEB Journal (1995), 9(7), 535-40

In this review of protein folding we consider the noncovalent interactions existing between atoms or molecules at the molecular level. The electrostatic, Van der Waals, hydrogen bonding, and hydrophobic ... [more ▼]

In this review of protein folding we consider the noncovalent interactions existing between atoms or molecules at the molecular level. The electrostatic, Van der Waals, hydrogen bonding, and hydrophobic interactions are described and their contribution to protein conformation is discussed. The growing interest in the hydrophobic effect arises from its importance in the protein folding process, and a semiempirical simulation of the free energy of solvation is proposed. In most proteins, the different forces we describe contribute to the stability of the protein conformation in a complex way. However, in the case of the apolipoproteins and cytochrome C551, the energetic contributions are easily distinguished. For this reason, these proteins are used to illustrate the importance of the different energy fields. [less ▲]

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