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See detailThe effects of training on ventilation and blood gases in exercising Thoroughbreds
Roberts, C. A.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1999), 30

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the ... [more ▼]

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the type frequently used for Thoroughbred racehorses in Great Britain. Standardized treadmill exercise tests (2 min canter at 8 and 10 m/s C8 and C10[ and 2 min gallop at 12 m/s [G12], on a level surface) were performed prior to and after 16 weeks of training. Respiratory flow rates were measured using ultrasound flow transducers. Blood samples were drawn from a transverse facial artery and the right atrium. Minute ventilation, respiratory frequency and tidal volume were not significantly altered by training. Peak inspiratory flow rate was lower following training at 8 and 10 m/s, but not at 12 m/s. Arterial oxygen tension was decreased during trot and canter following training. Blood lactate concentration post G12 decreased following training (10.5 +/- 2.2 mmol/l vs. 7.7 +/- 2.2 mmol/l; P < 0.05). The increase in the degree of exercise-induced arterial hypoxaemia following training may reflect a lack of pulmonary adaptation to training in the face of improved cardiovascular and muscular function. [less ▲]

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See detailShort-term toxicity of various pharmacological agents on the in vitro nitrification process in a simple closed aquatic system
Nimenya, H.; Delaunois, Annie; La Duong, Duc ULg et al

in Alternatives to Laboratory Animals (1999), 27

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures ... [more ▼]

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures of nitrifying bacteria. The purpose of this study was to quantify the inhibitory effects of 15 pharmacological agents, which are often used as therapeutic agents in ichthyopathology, on ammonia removal and nitrate production in a simple closed aquatic system. The experiments were conducted in polyethylene bags containing activated biofilters and synthetic water solutions, held in a water bath. Ammonia was added to initiate the nitrification process, and graded concentrations of various pharmacological agents were added. The effects of the pharmacological agents on in vitro nitrification were assessed by monitoring ammonia and nitrate concentrations compared to controls with no added agents, for 24 hours. Graded concentrations of ampicillin (Albipen(R)), chloramine T, enrofloxacin (Baytril(R)), erythromycin, levamisole, methylene blue and polymyxin B induced dose-dependent inhibitions of ammonia removal and nitrate production. The corresponding linear regression curves showed high correlation coefficients and were highly significant (p < 0.05). The addition of chloramphenicol, copper (II) sulphate, kanamycin disulphate, malachite green, neomycin sulphate, potassium penicillin G, tetracycline and a mixture of trimethoprim and sulphadoxin (Duoprim(TM)) had no significant effects on the nitrification process. A significant dose-related inhibition of nitrate production, but not of ammonia oxidation, was observed with enrofloxacin. The significant correlation (r = 0.940; p < 0.001) between the degrees of inhibition of ammonia oxidation and nitrate production for the various inhibitory pharmacological agents has also been calculated, with a view to validating this method. The data presented suggest that separate tank facilities for hospitalisation or quarantine are necessary when treating diseased fish with ampicillin, enrofloxacin, chloramine T, erythromycin, levamisole, methylene blue or polymyxin B, in order to avoid ammonia poisoning. [less ▲]

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See detailMaladie de Crohn. Récidives post-opératoires. Conduite à tenir.
Belaiche, Jacques ULg; Louis, Edouard ULg

in Acta Endoscopica (1999), 29

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See detailL'homeopathie est-elle superieure au placebo? Controverse a propos d'une meta-analyse des etudes controlees.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154(7-9), 295-304304-7

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not ... [more ▼]

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not rely on any scientific basis, it appears to be popular, especially in general practice. The homeopaths have recently taken arguments from a meta-analysis published in 1997 in the Lancet of 89 placebo-controlled trials. This study indeed concluded that the results are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo. However, this meta-analysis contains several methodological flaws. Furthermore, it is recognized that results of a meta-analysis may not be confirmed in large well-performed clinical trials. Thus, homeopathy should still provide the evidence that conventional medicine has regularly brought during the last two decades in many fields of therapeutics, with the respect of the rigorous rules of "Good Clinical Practice", leading to "Evidence-Based Medicine". [less ▲]

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See detailTreatment of Inflammatory Bowel Disease with Azathioprine: How to Use It in 1999
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1999), 62(4, Oct-Dec), 437-9

Azathioprine and 6-mercaptopurine are effective drugs in the management of steroid dependent and chronic active inflammatory bowel diseases. They are also well tolerated on the long term. However, their ... [more ▼]

Azathioprine and 6-mercaptopurine are effective drugs in the management of steroid dependent and chronic active inflammatory bowel diseases. They are also well tolerated on the long term. However, their use is still hampered by some drawbacks including delay before efficacy, 20-35% of non responders, relapse at withdrawal of the drugs, possible bone marrow toxicity and other side effects. During the last few years, these drawbacks have been challenged by important studies showing that a better knowledge of the metabolism of these drugs may help to improve their use. [less ▲]

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See detailThe SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory
Hubert, Philippe ULg; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Analytica Chimica Acta (1999), 391(2), 135-148

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data ... [more ▼]

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data evaluation are proposed by an SFSTP Commission dedicated to the validation of chromatographic methods in bioanalysis. In a series of meetings, members of this Commission have tried to elaborate a rational, practical and statistically reliable strategy to assure the quality of the analytical results generated. This strategy has been formalised in a guide and the main suggestions made by the Commission are summarised in the present paper. The SFSTP guide has been produced to help analysts from the pharmaceutical industry to validate their bioanalytical methods, It is the result of a consensus between professionals having expertise in bioanalytical and/or statistical fields. The suggestions presented in this paper should therefore help the analyst to design and perform the minimum number of validation experiments needed to obtain all the required information to establish and demonstrate the reliability of its analytical procedure. The SFSTP guide suggests a validation strategy in two steps: a pre-validation and the validation itself. An experimental design is described for each of these steps and the main aspects discussed in the paper are related to the selection of the most appropriate calibration model to fit experimental data and the most suitable way to determine the limit(s) of quantitation and subsequently the calibration range as well as the optimum number of experiments to be performed in the validation phase. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailImmunocytochemistry of lipids : chemical fixatives have dramatic effects on the preservation of tissue lipids
Maneta-Peyret, Lilly; Compère, Philippe ULg; Moreau, Patrick et al

in Histochemical Journal (The) (1999), 31

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See detailEther suicide poisoning by intravenous injection
LAMBERMONT, Bernard ULg; D'Orio, Vincenzo ULg

in Intensive Care Medicine (1999), 25(3), 338

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See detailChanges in endothermic transitions associated with light-induced chlorophyllide formation, as investigated by differential scanning calorimetry
Mysliwa-Kurdziel, B.; Franck, Fabrice ULg; Chahdi, M. A. O. et al

in Physiologia Plantarum (1999), 107(2), 230-239

The changes in thermal transitions associated with protochlorophyllide (Pchlide) into chlorophyllide (Chlide) phototransformation were investigated using sensitive differential scanning calorimetry (DSC ... [more ▼]

The changes in thermal transitions associated with protochlorophyllide (Pchlide) into chlorophyllide (Chlide) phototransformation were investigated using sensitive differential scanning calorimetry (DSC), Two groups of endothermic transitions, each composed of several components, were observed between 25 and 90 degrees C for prolamellar body (PLB) membranes isolated from etiolated wheat (Triticum aestivum) leaves. The first group, located in the 20-45 degrees C region, was strongly affected by a short light pulse given prior to measurement, A decrease of this group of transitions was observed shortly after illumination and it was hardly detected in PLBs measured after the Chlide Shibata shift. Calorimetric results were supported by 77-K fluorescence emission spectra measured for continuously heated samples at different temperatures. We interpreted the DSC band observed between 20 and 45 degrees C as due to the disaggregation of Pchlide- (or Chlide-)-reductase-NADPH complexes, More detailed analysis using Gaussian deconvolution showed that this band was composed of three transitions at 32, 39 and 41 degrees C. The second group of transitions was detected in the 45-80 degrees C region, the same as for mature thylakoids. Its main component at 60 degrees C was not affected significantly by a short light pulse. By comparison of thermograms obtained for PLBs with those for mature thylakoid membranes, this transition was identified as the ATPase denaturation band. [less ▲]

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See detailBiochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli.
Laraki, N.; Franceschini, N.; Rossolini, G. M. et al

in Antimicrobial agents and chemotherapy (1999), 43(4), 902-6

The blaIMP gene coding for the IMP-1 metallo-beta-lactamase produced by a Pseudomonas aeruginosa clinical isolate (isolate 101/1477) was overexpressed via a T7 expression system in Escherichia coli BL21 ... [more ▼]

The blaIMP gene coding for the IMP-1 metallo-beta-lactamase produced by a Pseudomonas aeruginosa clinical isolate (isolate 101/1477) was overexpressed via a T7 expression system in Escherichia coli BL21 (DE3), and its product was purified to homogeneity with a final yield of 35 mg/liter of culture. The structural and functional properties of the enzyme purified from E. coli were identical to those of the enzyme produced by P. aeruginosa. The IMP-1 metallo-beta-lactamase exhibits a broad-spectrum activity profile that includes activity against penicillins, cephalosporins, cephamycins, oxacephamycins, and carbapenems. Only monobactams escape its action. The enzyme activity was inhibited by metal chelators, of which 1,10-o-phenanthroline and dipicolinic acid were the most efficient. Two zinc-binding sites were found. The zinc content of the P. aeruginosa 101/1477 metallo-beta-lactamase was not pH dependent. [less ▲]

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See detailContribution of the quantitative interpretation of gamma-ray logs to the study of limestone exploitation, a case-study at Maizeret, Belgium
Halleux, Isabelle ULg

in Geoexploration (1999), 24(6), 461-470

Economic considerations constrain quarrymen in Wallonia to consider more profit-earning exploitation of limestone deposits and (or) to diversify their products. Gamma-ray logs contain information about ... [more ▼]

Economic considerations constrain quarrymen in Wallonia to consider more profit-earning exploitation of limestone deposits and (or) to diversify their products. Gamma-ray logs contain information about the geology, structure and quality of deposits. Quantitative interpretation of the logs is necessary in order to provide a reasonably good image of reality. The method proposed here consists in removing the effects of different parameters influencing the measurements (analog ratemeter, statistical noise, etc.) and in deconvolving the data in the frequency domain by the analytical impulse response function of the system. An example demonstrates that mathematical processing increases the lithologic and stratigraphic definition of the logs (bed boundaries, bed thicknesses) and offers a satisfactory characterization of the rocks along boreholes. Some of the quarrymen's questions can be answered from this analysis. [less ▲]

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See detailGEQUAC, an excess Gibbs energy model describing associating and non-associating liquid mixtures by a new model concept for functional groups
Egner, Katja; Gaube, Johann; Pfennig, Andreas ULg

in Fluid Phase Equilibria (1999), 158(381-389),

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See detailNondispersive two-electron wave packets in the collinear driven helium atom
Schlagheck, Peter ULg; Buchleitner, A.

in Europhysics Letters [=EPL] (1999), 46(1), 24-30

Nondispersive two-electron wave packets are found in the Floquet spectrum of the driven, one-dimensional helium atom. In classical phase space, they are anchored to the principal nonlinear resonance ... [more ▼]

Nondispersive two-electron wave packets are found in the Floquet spectrum of the driven, one-dimensional helium atom. In classical phase space, they are anchored to the principal nonlinear resonance between the collinear frozen planet orbit and the driving field linearly polarized along the orbit. These novel, highly correlated eigenstates of the driven three-body Coulomb problem, exhibit lifetimes of the order of 10(3)...10(7) periods of the driving field, with strong fluctuations reminiscent of chaos-assisted tunneling. [less ▲]

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See detailLes hélicobactéries chez les animaux mythe ou réalité? 2. Etudes bactériologique et clinique préliminaires chez les carnivores domestiques
Thomas, A.; Hardy, N.; De Mol, P. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailLe sens de la mesure
Lafontaine, Dominique ULg

in Echec à l'Echec (1999), (133), 14

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See detailCrystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis.
Bompard-Gilles, C; Villeret, V; Fanuel, L et al

in Acta Crystallographica Section D-Biological Crystallography (1999), 55(Pt 3), 699-701

Ochrobactrum anthropi possesses an L-aminopeptidase (DmpA) also able to act as a D-amidase/D-esterase. DmpA (40 kDa) is activated by auto-catalyzed protein splicing liberating an alpha-amino group ... [more ▼]

Ochrobactrum anthropi possesses an L-aminopeptidase (DmpA) also able to act as a D-amidase/D-esterase. DmpA (40 kDa) is activated by auto-catalyzed protein splicing liberating an alpha-amino group presumably used as a general base in the catalytic mechanism. Two crystal forms were obtained at 294 K in 13-16% PEG 2000 mono-methylether at pH 9.0, adding either 0.2 M magnesium chloride or 1 M lithium chloride. Crystals of the first form belong to the space group C2221 and diffract to 3.0 A resolution, whereas crystals of the second form belong to the space group P21212 and diffract to 2.3 A resolution. Initial screening for heavy-atom derivatives on form II crystals, has led to a well substituted Hg derivative. [less ▲]

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See detailOptimal acquisition of video images in reflected light microscopy
Pirard, Eric ULg; Lebrun, Vincent; Nivart, Jean-François

in European Microscopy and Analysis (1999), 60(9-11),

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See detailL'analyse discriminante décisionnelle : principes et application
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1999), (4), 41

The principles of discriminant analysis are described and illustrated by the iris data set published by Fisher [1936].

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See detailEGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.
Du, G.; Willet, K.; Mouithys-Mickalad, Ange ULg et al

in Free Radical Biology & Medicine (1999), 27

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to ... [more ▼]

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to impair respiratory activities and mitochondrial oxidative phosphorylation efficiency. ADP/O (2.57 +/- 0.11) decreased after anoxia/reoxygenation (1.75 +/- 0.09, p < .01), as well as state 3 and uncoupled respiration (-20%, p < .01), but state 4 respiration increased (p < .01). EGb 761 (50-200 microg/ml) had no effect on mitochondrial functions before anoxia, but had a specific dose-dependent protective effect after anoxia/reoxygenation. When mitochondria were incubated with 200 microg/ml EGb 761, they showed an increase in ADP/O (2.09 +/- 0.14, p < .05) and a decrease in state 4 respiration (-22%) after anoxia/reoxygenation. In EPR spin-trapping measurement, EGb 761 decreased the EPR signal of superoxide anion produced during reoxygenation. In conclusion, EGb 761 specially protects mitochondrial ATP synthesis against anoxia/reoxygenation injury by scavenging the superoxide anion generated by mitochondria [less ▲]

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See detailLocal order of the high-pressure metallic phase of liquid selenium: a diffraction study
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Le Bihan, T. et al

in Journal of Physics : Condensed Matter (1999), 11(50), 10243-1024910249

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength ... [more ▼]

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength of 0.149 Aring to investigate the local order of the metallic liquid. The diffraction pattern of liquid Se has been recorded with the large-volume Paris-Edinburgh cell between (20degC, 3 GPa) and (1650degC, 4.1 GPa). The local order of the metallic liquid selenium is found to be close to that of liquid tellurium. In particular, the coordination number Z increases with temperature from 2.6 to 3.0 [less ▲]

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See detailEffect of synthesis process and substrate on electrical and thermal transport properties of Bi-2212
Dorbolo, Stéphane ULg; Ausloos, Marcel ULg; Bougrine, Hassan ULg et al

in Journal of Superconductivity (1999), 12(5), 623-629

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade ... [more ▼]

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade BaZrO3 substrate. Those measurements show that the BaZrO3 substrate gives better superconducting properties to the Bi-2212 than the Al2O3 substrate. The effect of (1.0 T) weak magnetic field has been searched for. The thermal magnetoconductivity and the contributions of the magnetic field to the thermoelectrical power are studied and compared through fine measurements. An electronic contribution seems to appear already well above the critical temperature and to exist up to 200 degrees K. The onset temperature is thus deduced. [less ▲]

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See detailQuantitative palynology of Famennian events in the Ardenne-Rhine Regions.
Streel, Maurice ULg

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailUltrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon in horses.
Denoix, J. M.; Busoni, Valeria ULg

in Equine Veterinary Journal (1999), 31(3), 186-91

The ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon (AL-SDFT) in the horse is presented. Comparison between anatomical sections of isolated limbs and ultrasound ... [more ▼]

The ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon (AL-SDFT) in the horse is presented. Comparison between anatomical sections of isolated limbs and ultrasound scans of the distal antebrachium in sound horses enabled the authors to establish the normal reference ultrasonographic images of this structure. The AL-SDFT inserts 7-14 cm above the antebrachiocarpal joint on the palmaromedial aspect of the radius. Ultrasonographically it appears as an uniformly echogenic structure located deep to the median artery. The knowledge of ultrasonographic anatomy is essential for identification of abnormal images and assessment of AL-SDFT damage. [less ▲]

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See detailBibliothèques et Informatique médicale.
Delvenne, Catherine ULg; Pasleau, Françoise ULg

in Newsletter to European Health Librarians (1999), (54), 677-382

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See detailMise au point de pains composites à base de mélanges de farines de sorgho/blé et analyse texturale.
Balla, A.; Blecker, Christophe ULg; Oumarou, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(2), 69-77

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See detailModélisation spatiale de la sélection de l'habitat chez le Blaireau européen (Meles meles) au moyen d'un Système d'Information Géographique.
Vanhalle, L.; Defourny, P.; Dufrêne, Marc ULg

in Cahiers des Réserves Naturelles -Rnob (1999), 13

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See detailFrom Neural Stem Cells to Myelinating Oligodendrocytes
Rogister, Bernard ULg; Ben Hur, Tamir; Dubois-Dalcq, Monique

in Molecular & Cellular Neuroscience [=MCN] (1999), 14

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See detailDesign of a microwave array hyperthermia applicator with a semicircular reflector
V Sabariego, Ruth ULg; Landesa, Luis; Obelleiro, Fernando

in Medical & Biological Engineering & Computing (1999), 37(5), 612-617

The design of a hyperthermia applicator for heating biological tissues is presented in which the applicator consists of an array antenna surrounded by a perfect electrically conducting reflector. The heat ... [more ▼]

The design of a hyperthermia applicator for heating biological tissues is presented in which the applicator consists of an array antenna surrounded by a perfect electrically conducting reflector. The heat hazard to superficial tissues is reduced by the introduction of a dielectric protecting layer over them. A method of moments formulation is applied to approximate the electric field within the biological medium and a closed form expression is presented for the electromagnetic coupling problem, which enables an optimisation procedure to be performed. The applicator enhances both penetration and focusing: deep tumours, close to the bone region, are heated and the percentage of biologically healthy tissue exposed to a specific absorption rate (SAR) hazard level diminishes by 53.8%. [less ▲]

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See detailThe plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells
Dassonneville, L.; Wattez, N.; Mahieu, C. et al

in Anticancer Research (1999), 19(6B), 5245-5250

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See detailConsensus statement on the treatment of septic shock
Spapen, H.; Damas, Pierre ULg; D'Orio, Vincenzo ULg et al

in Acta Clinica Belgica (1999), 54(5), 256-262

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See detailTarif de cubage "peuplement" pour les mélèzes en belgique méridionale
Pauwels, Dominique; Rondeux, Jacques ULg

in Revue Forestière Française (1999), 51(5), 605-611

Dendrometric data taken from 150 temporary plots set up in even-aged stands of larch trees in southern Belgium (French-speaking region) were used to devise a "stand" volume table that expresses the stem ... [more ▼]

Dendrometric data taken from 150 temporary plots set up in even-aged stands of larch trees in southern Belgium (French-speaking region) were used to devise a "stand" volume table that expresses the stem solid volume (for log girths not less than 22 cm) per hectare of larch depending on the land surface areas and dominant tree heights. [less ▲]

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See detailA procedure for deriving accurate linear polarimetric measurements.
Lamy, H.; Hutsemekers, Damien ULg

in The Messenger (1999), 96

The authors present here a procedure written within the ESO MIDAS reduction package with the aim of deriving semi-automatically linear polarisation data from CCD images obtained with beam-splitters such ... [more ▼]

The authors present here a procedure written within the ESO MIDAS reduction package with the aim of deriving semi-automatically linear polarisation data from CCD images obtained with beam-splitters such as those available at the ESO 3.6-m telescope equipped with EFOSC2 or at the VLT equipped with FORS1. The method is adequate for point-like objects and was used for measuring quasar polarisation. [less ▲]

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See detailA scintigraphic study of post-massage blood flow in human lower limb
Vanderthommen, Marc ULg; Depresseux, J.C.; Dauchat, L. et al

in European Journal of Physical Medicine & Rehabilitation (1999), 8(6), 159-162

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See detailA Natural Method for Coupling Magnetodynamic H-Formulations and Circuit Equations
Dular, Patrick ULg; Geuzaine, Christophe ULg; Legros, Willy ULg

in IEEE Transactions on Magnetics (1999), 35(3), 1626--1629

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See detailConvergence of High Order Curl-Conforming Finite Elements
Geuzaine, Christophe ULg; Meys, B.; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1442--1445

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See detailUDP-N-Acetyl-alpha-D-glucosamine as acceptor substrate of beta-1,4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine.
Elling, Lothar; Zervosen, Astrid ULg; Gallego, Ricardo Gallego et al

in Glycoconjugate Journal (1999), 16(7), 327-36

The capacity of UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor substrate for beta-1,4-galactosyltransferase (beta4GalT1, EC 2.4.1.38) from human and bovine milk and for recombinant ... [more ▼]

The capacity of UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor substrate for beta-1,4-galactosyltransferase (beta4GalT1, EC 2.4.1.38) from human and bovine milk and for recombinant human beta4GalT1, expressed in Saccharomyces cerevisiae, was evaluated. It turned out that each of the enzymes is capable to transfer Gal from UDP-alpha-D-galactose (UDP-Gal) to UDP-GlcNAc, affording Gal(beta1-4)GlcNAc(alpha1-UDP (UDP-LacNAc). Using beta4GalT1 from human milk, a preparative enzymatic synthesis of UDP-LacNAc was carried out, and the product was characterized by fast-atom bombardment mass spectrometry and 1H and 13C NMR spectroscopy. Studies with all three beta4GalTs in the presence of alpha-lactalbumin showed that the UDP-LacNAc synthesis is inhibited and that UDP-alpha-D-glucose is not an acceptor substrate. This is the first reported synthesis of a nucleotide-activated disaccharide, employing a Leloir glycosyltransferase with a nucleotide-activated monosaccharide as acceptor substrate. Interestingly, in these studies beta4GalT1 accepts an alpha-glycosidated GlcNAc derivative. The results imply that beta4GalT1 may be responsible for the biosynthesis of UDP-LacNAc, previously isolated from human milk. [less ▲]

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See detailModélisation de la mise en oeuvre des boulons sertis précontraints
Drean, M.; Habraken, Anne ULg; Bouchair, A. et al

in Construction Métallique (1999), 4

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See detailLes anomalies congenitales des vaisseaux de la base du coeur: "ring" et "sling" vasculaires. A propos d'un cas
Radermecker, M. A.; Massin, M.; Grenade, Thierry ULg et al

in Revue Médicale de Liège (1999), 54(10), 823-8

We present a case of double aortic arch corrected by surgical interruption and full mobilization of the trachea and the esophagus. The vascular malformations of the supraaortic trunks, which form more or ... [more ▼]

We present a case of double aortic arch corrected by surgical interruption and full mobilization of the trachea and the esophagus. The vascular malformations of the supraaortic trunks, which form more or less complete vascular rings encircling the esophagus and the trachea, are reviewed. The different presentations of double aortic arch, aberrant subclavian arteries, and abnormal development of the pulmonary arteries are discussed. [less ▲]

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See detailExperimental and theoretical radiative lifetimes, branching fractions and oscillator strengths in Lu II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Monthly Notices of the Royal Astronomical Society (1999), 307

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See detailImmunohistochemical study of the rectus sheath and transversalis facia in adult groin hernias
PANS, Alain ULg; Pierard, Gérald ULg; Albert, Adelin ULg

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (1999), 3

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See detailMedicaments et grossesse.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(5), 409-14

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the ... [more ▼]

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the public as well as among medical doctors. However, the complexity of the problem, the lack of robust scientific data and the emotional context characterizing this period make the prescription of medications to a pregnant woman a difficult task for every people involved in health care, the pharmacist, the general practitioner and even the gynaecologist. [less ▲]

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See detailCompte-rendu de l'ouvrage de Commaille Jacques et Martin Claude : Les enjeux politiques de la famille
Orianne, Jean-François ULg

in Recherches Sociologiques et Anthropologiques (1999), (3),

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See detailMorphotypes et postures de vie et de mort chez les trilobites.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (1999), 56

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See detailHypnosedation: a valuable alternative to traditional anaesthetic techniques.
Faymonville, Marie-Elisabeth ULg; Meurisse, Michel ULg; Fissette, Jean ULg

in Acta Chirurgica Belgica (1999), 99(4), 141-6

Hypnosis has become routine practice in our plastic and endocrine surgery services. Revivication of pleasant life experiences has served as the hypnotic substratum in a series of over 1650 patients since ... [more ▼]

Hypnosis has become routine practice in our plastic and endocrine surgery services. Revivication of pleasant life experiences has served as the hypnotic substratum in a series of over 1650 patients since 1992. In retrospective studies, followed by randomised prospective studies, we have confirmed the usefulness of hypnosedation (hypnosis in combination with conscious IV sedation) and local anaesthesia as a valuable alternative to traditional anaesthetic techniques. The credibility of hypnotic techniques and their acceptance by the scientific community will depend on independently-confirmed and reproducible criteria of assessing the hypnotic state. Based on the clinical success of this technique, we were interested in confirming this phenomenon in healthy volunteers. The revivication of pleasant life experiences thus served as the cornerstone of a basic research program developed to objectify the neurophysiological attributes of the hypnotic state. We compared hypnosis to normal alertness with similar thought content. In our experience, the activation profile obtained during the hypnotic state was completely different from simple re-memoration of the same subject matter during normal alertness. This represents an objective and independent criteria by which to assess the hypnotic state. [less ▲]

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See detail4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; Podona, T. et al

in Acta Crystallographica (1999), C55

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See detailImplication des propriétés biomécaniques des muscles transformés dans le mécanisme de la cardiomyoplastie
Radermacker, M. A.; Sluse, Francis ULg; Focant, B. et al

in Journal of Cardiology (1999), 9

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See detailLa transmission du virus de l’hépatite C en milieu hospitalier
Delwaide, Jean ULg; Gerard, Christiane ULg; Belaiche, Jacques ULg et al

in Médecine et Hygiène (1999), 57

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See detailPlants associated with Tentaculites in a new Early Devonian locality from Morocco.
Gerrienne, Philippe ULg; Fairon-Demaret, Muriel ULg; Galtier, J et al

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailLes agents antiplaquettaires en chirurgie vasculaire périphérique
VAN DAMME, Hendrik ULg; DAVID, Jean-Louis ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1999), 54(2), 109-17

Prescription of platelet inhibitors after arterial surgery is common use. The major concern of the vascular surgeon is to maintain patency of arterial reconstructions. Major causes of graft failure or ... [more ▼]

Prescription of platelet inhibitors after arterial surgery is common use. The major concern of the vascular surgeon is to maintain patency of arterial reconstructions. Major causes of graft failure or arterial thrombosis are the non-thromboresistant nature of the grafts and of the endarterectomised or balloon-dilated surfaces, restenosis due to intimal hyperplasia and progression of atherosclerotic disease in in- or outflow vessels. Platelet adhesion and intimal injury are the primary causes in both processes of graft thrombosis and intimal hyperplasia. To understand how antiplatelet drugs can interfere with these processes, a brief review of platelet function, and of the main platelet inhibitors (aspirin, dypiridamole, ticlopidine) is given. The pathophysiology of intimal hyperplasia is discussed. From clinical trials of peripheral vascular surgery or percutaneous transluminal angioplasty with or without periprocedural antiplatelet therapy, it appears that platelet inhibitors reduce early failure rate by 50% (thrombosis rate at one year reduced from 40 to 20%). There is also evidence that antiplatelet drugs allow to slow down the progression of the atherosclerotic degenerative process in the outflow vessels and in other vascular territories. For the polyvascular patients with charged passed history, platelet inhibitors reduce the risk of myocardial or cerebral infarction by 30% (secondary prevention). Today, there is a general consensus that antiplatelet drugs, started the day before the procedure, are beneficial for early and late patency of peripheral vascular reconstructions (carotid endarterectomy, infrainguinal bypass grafts or endovascular procedures). [less ▲]

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See detailGenes for rare idiopathic generalized epilepsies: BFNC.
Singh, N.; Charlier, Carole ULg; Peiffer, A. et al

in Advances in neurology (1999), 79

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See detailS/SL/PPV : le prix de l'information du futur
Jérôme, Simone

in Cahiers de la Documentation = Bladen voor Documentatie (1999), (1), 3-25

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See detailPretransplant helper T-lymphocyte determination in bone marrow donors: acute graft-versus-host disease prediction and relation with long-term survival
Winandy, Marie ULg; Lewalle, Philippe; Deneys, Véronique et al

in British Journal of Haematology (1999), 105

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency ... [more ▼]

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency was estimated in limiting dilution cultures, and HLA-DR and CD 80 expression by stimulating cells was measured by flow cytometry. 12/19 patients experienced acute graft-versus-host disease (aGVHD) grade II–IV. A good correlation was found between high pretransplant HTLp frequency and grade II–IV aGVHD (median: 1/55848 PBMNC for II–IV GVHD versus 1/ 184346 for 0–I GVHD; P¼0·008). Sensitivity was 82%, specificity 63%, negative predictive value 71% and positive predictive value 75%. Long-term survivors also had a lower HTLp median frequency (1/143354) when compared with patients who died as a result of the transplant procedure (1/22100, P < 0·001). No correlation was found between HTLp frequency and HLA-DR or CD80 expression by patient’s cells. We conclude that HTLp frequency estimation can predict, although poorly, acute GVHD risk and long-term survival. [less ▲]

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See detailAllozymic variation and genetic structure of Scottish Calluna vulgaris populations the effect of postglacial recolonization
Mahy, Grégory ULg; Ennos, Richard; Jacquemart, Anne Laure

in Heredity (1999), 82

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See detailEffects on nicotine administered via a transdermal delivery system on vigilance : a repeated measure study
Mancuso, Giovanna; Andrès Bénito, Pilar; Ansseau, Marc ULg et al

in Psychopharmacology (1999), 142(1), 18-23

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing ... [more ▼]

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing test 1.3, 3 and 6.3 hrs after patch application, to verify the involvement of the dose of nicotine on the performance. The results confirm and extend the knowledge on the increasing effects of nicotine on vigilance previously found with orally and transdermally administered nicotine. Moreover, results show that such performance was independent of the time of nicotine absorption, which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time. ((c) 1999 APA/PsycINFO, all rights reserved) [less ▲]

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See detailThe generalist pollination system and reproductive success of Calluna vulgaris
Mahy, Grégory ULg; De Sloover, Jacques; Jacquemart, Anne Laure

in Canadian Journal of Botany (1999), 76

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See detailNanometer scale organization of mixed surfactin/phosphatidylcholine monolayers
Deleu, Magali ULg; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Biophysical Journal (1999), 77(4), 2304-2310

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic ... [more ▼]

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). AFM topographic images revealed phase separation for mixed monolayers prepared at 0.1, 0.25, and 0.5 surfactin molar ratios. This was in agreement with the monolayer properties at the air-water interface indicating a tendency of the two compounds to form bidimensional domains in the mixed systems. The step height measured between the surfactin and the DPPC domains was 1.2 +/- 0.1 nm, pointing to a difference in molecular orientation: while DPPC had a vertical orientation, the large peptide ring of surfactin was lying on the mica surface. The N/C atom concentration ratios obtained by XPS for pure monolayers were compatible with two distinct geometric models: a random layer for surfactin and for DPPC, a layer of vertically-oriented molecules in which the polar headgroups are in contact with mica. XPS data for mixed systems were accounted for by a combination of the two pure monolayers, considering respective surface coverages that were in excellent agreement with those measured by AFM. These results illustrate the complementarity of AFM and XPS to directly probe the molecular organization of multicomponent monolayers. [less ▲]

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See detailLe cas clinique du mois. Rupture couverte d'un anevrysme infectieux post-typhique de l'aorte abdominale sous-renale.
SCHILS, Fabian ULg; SakalihasanN, Natzi ULg; Sente, J. M. et al

in Revue Médicale de Liège (1999), 54(10), 786-8

Mycotic aneurysms are uncommon but remain one of the most challenging clinical problems for the vascular surgeon. They are associated with high morbidity and mortality, and the clinical signs and symptoms ... [more ▼]

Mycotic aneurysms are uncommon but remain one of the most challenging clinical problems for the vascular surgeon. They are associated with high morbidity and mortality, and the clinical signs and symptoms are non specific. We report here the case of an abdominal aorta mycotic aneurysm due to salmonellosis treated by insertion of an arterial homograft. [less ▲]

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See detailLes conditions de la rentabilité de la production d'embryons bovins par ponction folliculaire échoguidée et fécondation in vitro en Région Wallonne : première approche.
Dehareng, D.; Annet, C.; Dupont, F. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailLa transposition de "quaestor" en grec
Famerie, Etienne ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1999), 68

Critical survey of the three different ways (transliteration, translation, equivalence) to transpose a Latin technical term (quaestor, for example) into the Greek language

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See detailPubertal Growth as a Determinant of Adult Height in Boys with Constitutional Delay of Growth and Puberty
Rensonnet, Claudie ULg; Kanen, F.; Coremans, C. et al

in Hormone Research (1999), 51(5), 223-9

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult ... [more ▼]

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult height being above or below target height. In this retrospective study, adult height measured after 20 years in 39 patients was compared with target height and height data obtained at about 6 and 12 years of age and at diagnosis of delayed puberty (mean 14.6 years). Twenty-eight patients were untreated while 11 received testosterone enanthate (50 or 100 mg/month for 6 months). The growth data from both groups were pooled since they were not different. On average, the adult height standard deviation score (-0. 6 +/- 0.8, mean +/- SD) was similar to target height (-0.5 +/- 0.6). There were, however, marked individual differences since adult height varied between 1.7 SD (11 cm) below target height and 1.4 SD (9.5 cm) above target height. Multiple regression analysis showed that the most significant determinant of the difference between adult height and target height was height catch up during puberty (p < 0.002). We conclude that the magnitude of height catch up during puberty is a significant determinant of adult height in boys with constitutional delay of growth and puberty. Thus, optimizing pubertal growth may be a relevant therapeutic aim for adult height in boys with short stature and delayed puberty. Copyrightz1999S. KargerAG,Basel [less ▲]

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See detailImpairment of neocortical metabolism predicts progression in Alzheimer's disease
Herholz, K.; Nordberg, A.; Salmon, Eric ULg et al

in Dementia & Geriatric Cognitive Disorders (1999), 10(6), 494-504

Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset ... [more ▼]

Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible vs probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment. [less ▲]

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See detailPrognostic Factors in Urothelial Renal Pelvis and Ureter Tumours: a Multicentre Rare Cancer Network Study
Ozsahin, M; Zouhair, A; Villa, S et al

in European Journal of Cancer & Clinical Oncology (1999), 35/5

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter ... [more ▼]

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n=71), nephroureterectomy and lymphadenectomy (n=20), nephroureterectomy and partial bladder resection or transurethral resection (n=20), nephrectomy (n=10), and ureterectomy (n=5). Sixty-one per cent (n=77) of the tumours were located in the renal pelvis, and 21% (n=27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis. [less ▲]

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See detailForest inventories and biodiversity
Rondeux, Jacques ULg

in Unasylva (1999), 50(196), 35-41

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See detailOverexpression, purification and characterization of Mycobacterium bovis BCG alcohol dehydrogenase.
Wilkin, J. M.; Soetaert, K.; Stelandre, M. et al

in European Journal of Biochemistry (1999), 262(2), 299-307

A previous study of the effect of zinc deprivation on Mycobacterium bovis BCG pointed out the potential importance of an alcohol dehydrogenase for maintaining the hydrophobic character of the cell ... [more ▼]

A previous study of the effect of zinc deprivation on Mycobacterium bovis BCG pointed out the potential importance of an alcohol dehydrogenase for maintaining the hydrophobic character of the cell envelope. In this report, the effect of the overexpression of the M. bovis BCG alcohol dehydrogenase (ADH) in Mycobacterium smegmatis and M. bovis BCG is described. The purification of the enzyme was performed to apparent homogeneity from overexpressing M. bovis BCG cells and its kinetic parameters were determined. The enzyme showed a strong preference for both aromatic and aliphatic aldehydes while the corresponding alcohols were processed 100-1000-fold less efficiently. The best kcat/Km values were found with benzaldehyde > 3-methoxybenzaldehyde > octanal > coniferaldehyde. A phylogenetic analysis clearly revealed that the M. bovis BCG ADH together with the ADHs from Bacillus subtilis and Helicobacter pylori formed a sister group of the class C medium-chain alcohol dehydrogenases, the plant cinnamyl alcohol dehydrogenases (CADs). Comparison of the kinetic properties of our ADH with some related class C enzymes indicated that the mycobacterial enzyme substrate profile resembled that of the CADs involved in plant defence rather than those implicated in lignification. A possible role for the M. bovis BCG ADH in the biosynthesis of the lipids composing the mycobacterial cell envelope is proposed. [less ▲]

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See detailLes aliments industriels chez les carnivores domestiques : II. Choix des ingrédients et application aux aliments "Premium"
Derua, N.; Istasse, Louis ULg; Diez, Marianne ULg

in Annales de Médecine Vétérinaire (1999), 143

Over the last 10 years the number of premium foods is increasing in the petfood industry for companion animals. It is often difficult for the vets in practice to compare different premium foods. The ... [more ▼]

Over the last 10 years the number of premium foods is increasing in the petfood industry for companion animals. It is often difficult for the vets in practice to compare different premium foods. The ingredients sources used in diet formulation remain a criterion to indirectly evaluate the quality. A judicious choice of feedstuffs directly influences palatability and digestibility of each diet. The present paper aims to describe the different nutrient sources used in the premium foods industry. Each nutrient and its sources are presented separately starting by protein, fat and carbohydrates and ending with vitamins and minerals. Labelling according to the offical recommandations is also reported. [less ▲]

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See detailNumerical simulations of seasonal and interannual variability of the Black Sea thermohaline circulation
Stanev, Emil; Beckers, Jean-Marie ULg

in Journal of Marine Systems (1999), 22(4), 241-267

The Black Sea general circulation is simulated by a primitive equation model with active free surface. The forcing is seasonally variable and is based on available climatic data. The model reproduces the ... [more ▼]

The Black Sea general circulation is simulated by a primitive equation model with active free surface. The forcing is seasonally variable and is based on available climatic data. The model reproduces the main features of the Black Sea circulation, including the river discharge effects on the mean sea level and the Bosphorus outflow. Model results show that the simulated sea surface elevation increases in spring over the whole sea, reaching a maximum in the Danube delta area. In the same region, a minimum is observed in winter. The amplitude of the seasonal oscillations (about 8-12 cm over the whole basin) is of the same order of magnitude as the maximum horizontal variations (about 15-18 cm between the coastal areas and the basin interior). This strong signal formed mostly by river discharges, along with the seasonal variability in the other forcing functions and the local dynamics creates a well-pronounced interannual variability. The performance of the model in simulating the seasonal and interannual variability is critically analyzed, with a special attention on the cold intermediate water formation and the circulation in the upper 150 m. The simulations demonstrate that the source of intermediate waters is on the shelf, and that the water mass in the core of cold intermediate layer changes with time as a response to the periodic forcing at sea surface. This type of variability is characterized by pronounced interannual changes, proving that important differences could exist between water mass structure in different years, even when using identical atmospheric forcings each year. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailComment j'explore ... une suspicion de sténose d'artère rénale
Krzesinski, Jean-Marie ULg; Turatzinze, Léopold

in Revue Médicale de Liège (1999), 54(8), 702-704

Renal artery stenosis can present 2 clinical pictures, sometimes associated and potentially treatable, due mainly to atherosclerosis, but also to fibromuscular dysplasia. The first possible presentation ... [more ▼]

Renal artery stenosis can present 2 clinical pictures, sometimes associated and potentially treatable, due mainly to atherosclerosis, but also to fibromuscular dysplasia. The first possible presentation is renovascular hypertension which represents 1% of unselected hypertensive populations. The second possible presentation is ischemic renal disease, which represent 10% of the new indications for dialysis therapy and has a 50% mortality rate at 3 years. To explore this disease, arteriography, the gold standard, must be reserved for confirmation and treatment. Hypertension induced by the stenosis is best approached by captopril renal MAG 3 scintigraphy. Measurement of the stenosis severity can be performed either by duplex ultrasonography, magnetic resonance angiography or spinal CT angiography according to patients'characteristics, local experience and facilities. This disease must be searched in the presence of renal insufficiency of unknown cause or refractory hypertension. [less ▲]

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See detailLicéité des baux au regard de la police de l'aménagement du territoire et de l'urbanisme
Delnoy, Michel ULg

in Actualités Juridiques des Baux (1999)

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See detailCourteous behaviour concerning beetles sexuality
Haubruge, Eric ULg

in New Scientist (1971) (1999), 227(2184), 60

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See detailPremier signalement du Phytophthora de l’aulne (Alnus glutinosa) en Belgique
Cavelier, marc; Claessens, Hugues ULg; Etienne, Michel

in Parasitica (1999), 55

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See detailEtude rétrospective de l'incidence des troubles nereux rapportés et suspects d'encéphalopathie spongiforme transmissible chez les bovins en Belgique
Saegerman, Claude ULg; Claes, M.; Vanopdenbosch, E. et al

in Epidémiologie et Santé Animale (1999), 35

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See detail"Destinataire final" des subsides cherche privilège, note sous Bruxelles, 1e octobre 1997
Lissoir, Bénédicte ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailExploration isocinétique : analyse des courbes
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Annales de Réadaptation et de Médecine Physique (1999), 42

Introducition: La courbe isocinétique met en relation le moment de force développé et le positionnement articulaire: elle autorise l'étude in vivo de la relation classique tension-longueur. Le tracé ... [more ▼]

Introducition: La courbe isocinétique met en relation le moment de force développé et le positionnement articulaire: elle autorise l'étude in vivo de la relation classique tension-longueur. Le tracé isocinétique se caractérise occasionnellement par un profil anormal. Méthode: Sur la base de l'expérience clinique, les auteurs proposent une classification d'anomalies; plusieurs facteurs contribuent à leur apparition: une collaboration ou une familiarisation insuffisante du patient, un protocole inadéquat, une amyotrophie majeure, une modification de la biomécanique articulaire, des troubles neurologiques ainsi que des phénomènes algiques au cours de l'exercice. Discussion et conclusion: L'intérêt diagnostique des courbes isocinétiques ne semble pas crédible, comme l'indique une étude centrée sur la nature et la fréquence des anomalies dans différents groupes de lésions opérées ou non opérées du ligament croisé antérieur. Sous réserve d'une analyse rigoureuse, les implications rééducatives paraissent néanmoins intéressantes lorsqu'une anomalie reproductible de la courbe s'accompagne d'un phénomène algique. [less ▲]

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See detailStudy of the mechanism of direct laser desorption/ionisation for some small organic molecules (M < 400 daltons)
Benazouz, M.; Hakim, B.; Debrun, J. L. et al

in Rapid Communications in Mass Spectrometry : RCM (1999), 13(23), 2302-2304

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates ... [more ▼]

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates, and a nitrogen laser is used for desorption/ionisation; ion yields are measured with a time-of-flight mass spectrometer, Previous work had shown that ion yields can strongly vary from one substrate to another, and that this variation does not reflect the (calculated) metal surface temperatures. New results obtained in this work indicate that the desorption/ionisation mechanism is linked to the physical state of the substrate surface. Copyright (C) 1999 John Wiley & Sons, Ltd. [less ▲]

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See detailSur philellên chez Cicéron
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1999), 68

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See detailHigh Prevalence of Low Femoral Bone Mineral Density in Elderly Women Living in Nursing Homes or Community-Dwelling: A Plausible Role of Increased Parathyroid Hormone Secretion
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Pirenne, H. et al

in Osteoporosis International (1999), 9(2), 121-8

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH ... [more ▼]

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH vitamin D (25-OHD) with those of subjects living at home, in the immediate vicinity of the nursing homes. Of 1483 women, aged 70 years and older, who were selected, 993 agreed to participate in this trial. Their femoral neck BMD (n = 993) was measured by dual-energy X-ray absorptiometry, with a specific device installed in a mobile truck. The circulating levels of 25-OHD and PTH were assessed after an overnight fast (n = 748). After stratification for age, there were no significant differences in mean femoral neck BMD values, prevalence of femoral neck osteoporosis, mean serum 25-OHD and prevalence of absolute or relative 25-OHD deficiency between the two groups. Serum levels of PTH were significantly higher in women over 80 years old living in nursing homes, compared with the community-dwelling women. After adjustment for age, a significant relation was found between femoral neck BMD and PTH levels in the whole population (p = 0.004) and in community-dwelling subjects (p = 0.039). When stratifying our population by quartiles of serum PTH values, the odds ratios for femoral neck osteoporosis were significantly increased for the top two quartiles compared with the lowest one both before (p = 0.00146) and after (p = 0.0013) adjustment for age and type of housing. From this study we conclude that femoral osteoporosis is largely underestimated in European women. Living in a nursing home is not, per se, a risk factor for decreased femoral BMD, and circulating PTH levels are a key determinant of low femoral bone density and osteoporosis. [less ▲]

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See detailLes adénovirus recombinants comme vecteurs vaccinaux
Gogev, S.; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (1999), 143

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See detailImpact of dolomite lime on the ground vegetation and on potential net N transformations in Norway spruce (Picea Abies (L.) Karst.) and sessile oak (Quercus Petraea (Matt.) Lieb.) stands in the Belgian Ardenne
Duliere, J.-F.; Carnol, Monique ULg; Dalem, S. et al

in Annals of Forest Science : a Multidisciplinary and International Journal (1999), 56

The impact of dolomite lime (5 T·ha-1) on the ground vegetation and on potential net nitrogen (N) transformations was investigated in two Belgian forest ecosystems. Norway spruce (Picea abies (L.) Karst ... [more ▼]

The impact of dolomite lime (5 T·ha-1) on the ground vegetation and on potential net nitrogen (N) transformations was investigated in two Belgian forest ecosystems. Norway spruce (Picea abies (L.) Karst.) and sessile oak (Quercus petraea (Matt.) Lieb.) stands were situated in the Haute Ardenne (east Belgium) on acid-brown soil. The herb-layer floristic richness increased during the 2 years following liming, with the appearance of light and N-demanding species, which are also found in clear-cut areas or on road verges. Mosses reacted rapidly, showing a decrease acidophilous-dominant species and the establishment of some ruderal species. Six months after liming, the pH was significantly increased in the organic horizon of both stands and in the organomineral horizon of the oak stand. Soils originating from the two stands showed distinct responses in net NO3- production to the dolomite lime treatment. In the organic layer of the Quercus soil, net NH4+ production was decreased, NO3- production increased, and total N mineralisation remained unchanged. In the organomineral layer, NO3 - production was increased. In the Picea soil, NO3 - production was decreased in the organomineral soil layer. These results indicate the possibility of differences in the control of the N transformation processes occurring in the two sites. [less ▲]

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See detailUnimolecular Dynamics from Kinetic Energy Release Distributions. V. How does the Efficiency of Phase Space Sampling vary with Internal Energy?
Hoxha, A.; Locht, Robert ULg; Lorquet, Andrée ULg et al

in Journal of Chemical Physics (1999), 111(20), 9259-9266

A retarding field technique coupled with a quadrupole mass analyzer has been used to obtain the kinetic energy release distributions (KERDs) for C2H3Br+->[C2H3]++Br dissociation as a function of the ... [more ▼]

A retarding field technique coupled with a quadrupole mass analyzer has been used to obtain the kinetic energy release distributions (KERDs) for C2H3Br+->[C2H3]++Br dissociation as a function of the internal energy. The KERDs obtained by dissociative photoionization using the He(I), Ne(I) and Ar(II) resonance lines were analyzed by the maximum entropy method and were found to be well described by introducing a single dynamical constraint, namely the relative translational momentum of the fragments. Ab initio calculations reveal the highly fluxional character of the C2H3+ ion. As the energy increases, several vibrational modes are converted in turn into large-amplitude motions. Our main result is that, upon increasing internal energy, the fraction of phase space sampled by the pair of dissociating fragments is shown to first decrease, pass through a shallow minimum around 75%, and then increase again, reaching almost 100% at high internal energies (8 eV). This behaviour at high internal energies is interpreted as resulting from the conjugated effect of intramolecular vibrational redistribution (IVR) and radiationless transitions among potential energy surfaces. Our findings are consistent with the coincidence data of Miller and Bear, reanalyzed here, and with the KERD of the metastable dissociation. [less ▲]

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See detailCardiac autonomic dysfunction in diabetic children.
Massin, M. M.; Derkenne, B.; Tallsund, M. et al

in Diabetes care (1999), 22(11), 1845-50

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can ... [more ▼]

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can be used to detect subclinical autonomic neuropathy in diabetic children. RESEARCH DESIGN AND METHODS: We examined five time domain and three frequency domain HRV indices determined from 24-h Holter recordings in 73 diabetic children and adolescents aged 3-18 years (mean 12.1 years) with a mean duration of diabetes of 55 months. The measures were compared with normal ranges. Z scores were established for each parameter and were compared with classic risk factors of other diabetic complications. RESULTS: Most HRV indices were significantly depressed in children aged > or = 11 years, and the levels of HRV abnormalities were significantly correlated with long-term metabolic control (mean GHb for 4 years) in that age-group. In younger patients, HRV indices were within the normal range and were not correlated with the level of metabolic control. Illness duration and microalbuminuria but not short-term metabolic control (most recent GHb) were also independently predictive of HRV abnormalities. CONCLUSIONS: These results suggest that early puberty is a critical period for the development of diabetic cardiac autonomic dysfunction. Therefore, all type 1 diabetic patients should be screened for this complication by HRV analysis beginning at the first stage of puberty regardless of illness duration, microalbuminuria, and level of metabolic control. [less ▲]

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See detailDerived Limits in Quasi-Abelian Categories
Prosmans, Fabienne ULg

in Bulletin de la Société Royale des Sciences de Liège (1999), 68(5-6), 335-401

We study the derived functors of projective limit functors in quasi-abelian categories.

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See detailSème inhérent et sème afférent. Examen des critères théoriques dans la sémantique interprétative de François Rastier
Badir, Sémir ULg

in Travaux de linguistique : revue internationale de linguistique Française (1999), 38

La sémantique interprétative, dont la rentabilité des applications, tant dans les études littéraires que dans les analyse de bases de données lexicologiques, n’est plus à vanter, repose sur quelques ... [more ▼]

La sémantique interprétative, dont la rentabilité des applications, tant dans les études littéraires que dans les analyse de bases de données lexicologiques, n’est plus à vanter, repose sur quelques critères théoriques relatifs à la détermination des différents types de sèmes (sème inhérent et sème afférent; sème spécifique et sème générique). On s’attache ici d’abord à montrer que ces critères, en dépit de leurs points d’ancrage dans la théorie structurale, ne sont pas définis de manière satisfaisante par François Rastier, initiateur et théoricien de cette sémantique. Puis on propose, au moins à titre d’hypothèse théorique dépourvue de contradiction, une nouvelle formulation des critères distinctifs des sèmes. [less ▲]

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See detailPronostic Implications of semi-supine stress echocardiography for evaluation of chest pain in the emergency room
LANCELLOTTI, Patrizio ULg; HOFFER, E; APPELTANS, H et al

in European Journal of Echocardiography (1999)

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See detail- Evolution of lipoxygenase activity during storage of potato tubers (Solanum tuberosum L. cv. Bintje)
Fauconnier, Marie-Laure ULg; Koto, N.; Hoyaux, P. et al

in Bulletin de la Société des Sciences de Liège (1999), 68(5-6), 319

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See detailHuman Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.
Colige, Alain ULg; Sieron, A. L.; Li, S. W. et al

in American Journal of Human Genetics (1999), 65(2), 308-17

Ehlers-Danlos syndrome (EDS) type VIIC is a recessively inherited connective-tissue disorder, characterized by extreme skin fragility, characteristic facies, joint laxity, droopy skin, umbilical hernia ... [more ▼]

Ehlers-Danlos syndrome (EDS) type VIIC is a recessively inherited connective-tissue disorder, characterized by extreme skin fragility, characteristic facies, joint laxity, droopy skin, umbilical hernia, and blue sclera. Like the animal model dermatosparaxis, EDS type VIIC results from the absence of activity of procollagen I N-proteinase (pNPI), the enzyme that excises the N-propeptide of type I and type II procollagens. The pNPI enzyme is a metalloproteinase containing properdin repeats and a cysteine-rich domain with similarities to the disintegrin domain of reprolysins. We used bovine cDNA to isolate human pNPI. The human enzyme exists in two forms: a long version similar to the bovine enzyme and a short version that contains the Zn++-binding catalytic site but lacks the entire C-terminal domain in which the properdin repeats are located. We have identified the mutations that cause EDS type VIIC in the six known affected human individuals and also in one strain of dermatosparactic calf. Five of the individuals with EDS type VIIC were homozygous for a C-->T transition that results in a premature termination codon, Q225X. Four of these five patients were homozygous at three downstream polymorphic sites. The sixth patient was homozygous for a different transition that results in a premature termination codon, W795X. In the dermatosparactic calf, the mutation is a 17-bp deletion that changes the reading frame of the message. These data provide direct evidence that EDS type VIIC and dermatosparaxis result from mutations in the pNPI gene. [less ▲]

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See detailPseudoscalar vertex, Goldstone boson and quark masses on the lattice
Cudell, Jean-René ULg; Le Yaouanc, A.; Pittori, Carlotta

in Physics Letters B (1999), 454

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See detailReview of bone formation stimulants
Reginster, Jean-Yves ULg

in Osterologia-Osteology (1999), 2

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See detailHypnoanesthesia for endocrine cervical surgery: a statement of practice.
Defechereux, Thierry ULg; Meurisse, Michel ULg; Hamoir, Etienne ULg et al

in Journal of Alternative & Complementary Medicine : Research on Paradigm, Practice, & Policy (1999), 5(6), 509-20

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and ... [more ▼]

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnoanesthesia (HYP) using Erikson's method. Operative data and postoperative course of this initial series were compared to a contemporary population of patients (n = 119) clinically similar except that they declined HYP or were judged unsuitable for it, and who were therefore operated on under general anesthesia (GA). RESULTS: The surgeons all reported better operating conditions for cervicotomy using HYP. Conversion from hypnosis to GA was needed in two cases (1%). All patients having HYP reported a pleasant experience and, keeping in mind that the GA group is not a randomly assigned control group, both had significantly less postoperative pain and analgesic use. Hospital stay was also significantly shorter, providing a substantial reduction in the costs of medical care. The postoperative convalescence was significantly improved after HYP and a full return to social or professional activity was significantly quicker. CONCLUSION: From this study, we conclude that HYP is an effective technique for providing relief of intraoperative and postoperative pain in endocrine cervical surgery. The technique results in high patient satisfaction and better surgical convalescence. This technique can therefore be used in most well-chosen patients and reduces the socioeconomic impact of hospitalization. [less ▲]

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See detailCerebral metabolism during vegetative state and after recovery to consciousness
Laureys, Steven ULg; Lemaire, Christian ULg; Maquet, Pierre ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (1999), 67(1), 121-122

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See detailCD44v6 expression is an independent prognostic factor in node-negative FIGO stage IB cervical carcinoma.
Speiser, P.; KRIDELKA, Frédéric ULg; Tempfer, C. et al

in International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society (1999), 9(2), 160-165

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing ... [more ▼]

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing receptor," CD44 is physiologically involved in migration of circulating lymphocytes to lymphatic tissue. In the present study, we investigated the expression of CD44v3 and v6 in 237 patients with stage IB, N0 cervical carcinoma by means of immunohistochemistry. These results were correlated with the GOG score and other prognostic variables. Median follow-up was 82.6 months (39-110 months). Thirty-nine patients recurred and 35 died from disease within the observation period. In univariate analysis, the GOG score, histologic subtype, and CD44v6 expression were statistically significant predictors for poor overall survival (OS). In multivariate (Cox regression) analysis, the GOG score (< 40 vs. 40-120, RR: 1.37 (95% CI: 1.10-1.71); 40-120 vs. > 120, RR: 2.23 (95% CI: 1.28-3.88); P = 0.004), histologic subtype (adenosquamous carcinomas) (RR: 4.56 (95% CI: 1.49-13.92), P = 0.007) and CD44v6 expression (RR: 2.42 (95% CI: 1.14-5.10), P = 0.021) were independent predictors for poor OS. The expression of CD44v3 did not correlate with prognosis. Furthermore we found a strong correlation between CD44v6 expression and lymphovascular space invasion (LVSI) (chi2 = 17.01, P = 0.0001). Tumor expansion into the loco-regional lymphatic system is the preferred way of tumor spread in cervical carcinoma. The strong correlation of CD44v6 with LVSI produces a significant degree of suspicion that cervical carcinoma cells expressing CD44v6 could, by mimicking lymphocytes, exploit their pathways. [less ▲]

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See detailMcLuhan, trente ans après
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailThe Locus for Enterocyte Effacement (Lee) of Enteropathogenic Escherichia Coli (Epec) from Dogs and Cats
Goffaux, F.; China, B.; Janssen, L. et al

in Advances in Experimental Medicine and Biology (1999), 473

Enteropathogenic Escherichia coli (EPEC) produce attaching and effacing lesions. The genes responsible for this lesion are clustered on the chromosome forming a 35.5 kilobase pathogenesis island called ... [more ▼]

Enteropathogenic Escherichia coli (EPEC) produce attaching and effacing lesions. The genes responsible for this lesion are clustered on the chromosome forming a 35.5 kilobase pathogenesis island called LEE. The LEE was identified, characterized and completely sequenced from the human EPEC strain E2348/69. The LEE carries genes coding for: a type III secretion system (genes esc and sep), the translocated intimin receptor (gene tir), the outer membrane protein intimin (gene eae) and the E. coli secreted proteins EspA, EspB, and EspD (genes esp). In addition to man and farm animals, EPEC are also isolated from dogs and cats. We studied structurally and functionally the LEE of dog and cat EPEC. First, we used four probes scattered along the LEE to identify the presence of a LEE in canine and feline EPEC isolates. Second, by PCR, we checked the presence of genes homologous to eae, sep, esp, and tir genes in these strains. Third, since the four types of eae and tir genes were described, we developed a multiplex PCR in order to determine the type of eae and tir genes present in each strain. Fourth, we determined by PCR the site of the LEE insertion on the chromosome. Fifth, we tested several of the canine EPEC in their capacity to induce attaching and effacing lesions in the rabbit intestinal loop assay. We can conclude from this study: first, that the a LEE-like structure is present in all tested strains and that it contains genes homologous to esp, sep, tir, and eae genes; second, that there is some preferential associations between the type of eae gene and the type of tir gene present in a strain; third, that the majority of the tested strains contained a LEE located elsewhere on the chromosome in comparison to the human EPEC strain E2348/69; and fourth that dog EPEC were able to induce attaching and effacing lesions in rabbit ileal loop assay. [less ▲]

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See detailComparison of ventrodorsal and dorsoventral radiographic projections for hip dysplasia diagnosis
Saunders, J.; Godefroid, T.; Snaps, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1999), (145), 109-110

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See detailL'obligation naturelle du père biologique de fournir des aliments à son enfant. Note sous Liège, 15 juin 1998
Genicot, Gilles ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detail33 Amplified rDNA restriction analysis and further genotypic characterisation of metal-resistant soil bacteria and related facultative hydrogenotrophs
Brim, Hassan; Heyndrickx, Marc; De Vos, Paul et al

in Systematic & Applied Microbiology (1999), 22

The level of genotypic relationship between czc+ soil bacteria mainly resistant to zinc (but also to various other metals), and related facultative hydrogenotrophs previously assigned to the genera ... [more ▼]

The level of genotypic relationship between czc+ soil bacteria mainly resistant to zinc (but also to various other metals), and related facultative hydrogenotrophs previously assigned to the genera Alcaligenes, Ralstonia, and Burkholderia was evaluated using ARDRA (Amplified Ribosomal DNA Restriction Analysis). The analysis included 44 strains isolated from harsh industrial environments in sediments, soils and wastes with high content of heavy metals. These strains were selected by their ability to grow in the presence of high concentrations of multiple heavy metals and to hybridise with czc or ncc probes. The czc operon confers resistance to cadmium, zinc and cobalt in strain Ralstonia eutropha CH34. The net operon confers resistance to nickel, cobalt and cadmium in strain 31A known as Alcaligenes xylosoxidans. The analysis showed a close phylogenetic clustering of the czc+ strains inside the Ralstonia genus despite of their different origins and that the Ralstonia genus contained also the hydrogenotrophs and some catabolic strains assigned to the genus Ralstonia eutropha, strains up to now registrated as CDC IV c-2 strains as well as reference strains belonging to Ralstonia solanacearum and Ralstonia pickettii. The ncc+ strains are phylogenetically less related to each other compared to the czc+ strains. This suggests that the tested czc+ strains and some of the ncc+ strains may be considered as belonging to the genus Ralstonia. Inside this major Ralstonia cluster, a subcluster gathers most of the czc+ isolates maybe giving a clue to define a new species. Besides, from 30 tested strains, 15 metal resistant strains of this subcluster proved to display the unusual mutator phenotype characteristic of the representative strain CH34 [less ▲]

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See detailAlcoholic's deficit in the decoding of emotional facial expression
Philippot, P; Kornreich, C; Blairy, Sylvie ULg et al

in Alcoholism, Clinical & Experimental Research (1999), 23(6), 1031-1038

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See detailNon oxidative fructose disposal is not inhibited by lipids in humans.
Surmely, J. F.; Paquot, Nicolas ULg; Schneiter, P. et al

in Diabètes & Métabolism (1999), 25(3), 233-40

Elevated free fatty acid concentrations are known to decrease insulin-mediated glucose uptake, glucose oxidation and glycogen synthesis. In order to determine whether free fatty acids inhibit glycogen ... [more ▼]

Elevated free fatty acid concentrations are known to decrease insulin-mediated glucose uptake, glucose oxidation and glycogen synthesis. In order to determine whether free fatty acids inhibit glycogen synthesis at the level of liver cells, the effects of an infusion of lipids on carbohydrate metabolism were investigated in healthy subjects during a two-step (16.7 and 33.4 mumol/(kg.min) 13C-fructose infusion. Fructose infusion dose-dependently stimulated fructose (measured from 13CO2 production) and net carbohydrate oxidation (measured with indirect calorimetry). It also stimulated systemic 13C glucose appearance, indicating a dose-dependent stimulation of gluconeogenesis. Net glucose output (measured with 6,6 2H glucose) was however not altered. Lipid infusion significantly reduced fructose oxidation (measured from 13CO2 production) at both rates of fructose infusion, but did not alter plasma fructose or lactate concentrations, nor plasma 13C glucose appearance or net glucose production. Non oxidative fructose disposal was increased by 31% (p < 0.05) at the lowest, and by 18% (p < 0.01) at the highest infusion rate. Since nonoxidative fructose disposal corresponds mainly to liver glycogen deposition, these results suggest that lipid infusion increased hepatic glycogen synthesis, and hence that hepatic glycogen synthase is not inhibited by fatty acids. [less ▲]

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