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See detailViolence et justice
Steinmetz, Rudy ULg

in Avancées (1995)

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See detailMediators in critical illness
Deby, Ginette ULg; Lamy, Maurice ULg

in Current Anaesthesia and Critical Care (1995), 6(1), 3-9

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See detailVenous Allografts for Critical Limb Ischaemia
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1995), 95(1, Jan-Feb), 14-20

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level ... [more ▼]

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level. Recently, there is renewed interest in the use of preserved venous allografts as an alternate conduit in patients with threatened ischaemic limbs. From 1991 to 1993, the authors revascularized 12 ischaemic limbs with venous allografts (10 preserved at 4 degrees C, 2 Varivas grafts). The indication for operation was rest pain in five patients and tissue necrosis in seven. Nine patients had one or more previous ipsilateral revascularizations. The at 4 degrees C preserved venous allografts were conserved for a near period of 2 months. In only half (5/10) of the cases ABO isocompatibility could be respected. Distal anastomosis was always below the knee. In 6 patients, the anastomosis was at tibial level. There was one rupture of a Varivas graft on the fifth postoperative day, necessitating ligation of the graft and subsequent amputation. All other grafts remained patent for a mean period of 10.6 months. Actually, 6 grafts are still open. Most patients were given aspirin. Only three patients were under oral coumarin anticoagulation in an effort to prevent early graft failure. The limb salvage rate is 67% (8/12) (mean follow-up of 13 months). The authors discuss the clinical experience with venous allografts as published in recent literature. Use of venous allografts for arterial reconstruction in humans was met with limited success so far. The one year patency approximates 50%. Venous allografts progress in an ineluctable way to a fibrous conduit.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailOn the presence of a day-of-the-week effect in the foreign exchange market
Corhay, Albert ULg; Fatemi, Ali M; Tourani-Rad, Alireza

in Managerial Finance (1995), 21(8), 32-43

The purpose of this paper is to study the presence of the day-of-the-week effect in the foreign exchange market using an extensive data set of six exchange rates and employing two alternative types of ... [more ▼]

The purpose of this paper is to study the presence of the day-of-the-week effect in the foreign exchange market using an extensive data set of six exchange rates and employing two alternative types of distributional assumptions and also distribution-free tests. Our findings support the hypotheses of higher Wednesday returns prior to October 1, 1981, for the British pound, the Canadian dollar, the Deutsch mark, the French franc, the Swiss franc and the Japanese yen. Pursuant to the change in the settlement procedures which took effect October 1, 1981, the differential Wednesday returns disappear. [less ▲]

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See detailApplication des transects pluviométriques spatio-temporels annuels à l’ensemble du territoire sahélien.
Ozer, Pierre ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailScreening for in vitro Antifungal Activities of some Indole Alkaloids
Quetin-Leclercq, J.; Favel, A.; Balansard, G. et al

in Planta Medica (1995), 61

Thirty indole alkaloids were tested by the agar dilution technique on a panel of human pathogenic fungi, yeasts and dermatophytes. Our results indicate that the most active compounds possess a beta ... [more ▼]

Thirty indole alkaloids were tested by the agar dilution technique on a panel of human pathogenic fungi, yeasts and dermatophytes. Our results indicate that the most active compounds possess a beta-carboline skeleton and that the presence of a 3,4 double bond enhances the activity. Our results also show that antifungal activities are not linked to the cytotoxic, antimicrobial or antiparsitic properties. [less ▲]

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See detailEffects of PEEP on systemic vascular compliance in intact pigs
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detail3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailMonoclonal antibodies against bovine growth hormone (bGH) enhance the biological response to GH by prolonging GH binding to its liver receptors.
Beauloye, V.; Muaku, S. M.; Portetelle, Daniel ULg et al

in Endocrinology (1995), 136(Suppl 1), 344

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See detailBreakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates.
Damblon, Christian ULg; Zhao, G. H.; Jamin, M. et al

in Biochemical Journal (1995), 309 ( Pt 2)

With peptide analogues of their natural substrates (the glycopeptide units of nascent peptidoglycan), the DD-peptidases exhibit a strict preference for D-Ala-D-Xaa C-termini. Gly is tolerated as the C ... [more ▼]

With peptide analogues of their natural substrates (the glycopeptide units of nascent peptidoglycan), the DD-peptidases exhibit a strict preference for D-Ala-D-Xaa C-termini. Gly is tolerated as the C-terminal residue, but with a significantly decreased activity. These enzymes were also known to hydrolyse various ester and thiolester analogues of their natural substrates. Some thiolesters with a C-terminal leaving group that exhibited L stereochemistry were significantly hydrolysed by some of the enzymes, particularly the Actinomadura R39 DD-peptidase, but the strict specificity for a D residue in the penultimate position was fully retained. These esters and thiolesters also behave as substrates for beta-lactamases. In this case, thiolesters exhibiting L stereochemistry in the ultimate position could also be hydrolysed, mainly by the class-C and class-D enzymes. However, more surprisingly, the class-C Enterobacter cloacae P99 beta-lactamase also hydrolysed thiolesters containing an L residue in the penultimate position, sometimes with a higher efficiency than the D isomer. [less ▲]

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See detail3-Methyl-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailFra Stein til Waldrop: sprogdigtningen og de nye prosadigtere
Delville, Michel ULg; Schatz-Jakobsen, Claus

in Den Blå Port: Tidsskrift for Litteratur (1995)

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See detailNouveaux activateurs des canaux potassiques: conception, pharmacologie et perspectives thérapeutiques
Pirotte, Bernard ULg; Fontaine, J.; Lebrun, P.

in Journal de Pharmacie de Belgique (1995), 50

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See detailGrecs et Latins face aux langues étrangères. Contribution à l'étude de la diversité linguistique dans l'antiquité classique
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (1995), 73(1), 5-16

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See detailPlasma progesterone and IGF-I levels at puberty in Italian Simmental and Friesian heifers with various genetic merit.
Prandi, A.; Rossi, C.; Tondolo, A. et al

in Journal of Animal Science (1995), 73(Suppl 1), 222

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See detailQui est Apollonios ? (UPZ II 227)
Rochette, Bruno ULg

in Aegyptus (1995), 75

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See detailLate Lower and Middle Devonian Miospores from Saudi Arabia.
Loboziak, S; Streel, Maurice ULg

in Review of Palaeobotany and Palynology (1995), 89

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See detailOn the charge transfer pathway in the Merocyanine 540 triplet state quenching by nitroxyl radical
Hoebeke, Maryse ULg; Van de Vorst, A.

in Photochemistry & Photobiology (1995), 61

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See detailGrecs et Latins deux fois parents ? Aux origines de la conscience ethnique et linguistique des Grecs et des Romains
Rochette, Bruno ULg

in Cahiers de Clio (1995), 121-122(printemps-été), 69-84

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See detailLa traduction de textes religieux dans l'Egypte gréco-romaine
Rochette, Bruno ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1995), 8

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See detailNucleic acid compartmentalization within the cell nucleus by in situ transferase-immunogold techniques.
Thiry, Marc ULg

in Microscopy Research and Technique (1995), 31(1), 4-21

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is ... [more ▼]

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is placed on the various nucleolar components and the various enigmatic structures of the extranucleolar region: interchromatin granules, coiled bodies, and simple nuclear bodies. These data are discussed in the light of our current understanding of the functional organization of the cell nucleus. [less ▲]

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See detailExégèse de Paul. D. 39,3 (de aqua et aquae pluviae arcendae), 2,6
Gerkens, Jean-François ULg

in Tijdschrift voor Rechtsgeschiedenis (1995), 63(1995/1), 11-26

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See detailFunctional analysis of the Antirrhinum floral homeotic DEFICIENS gene in vivo and in vitro by using a temperature-sensitive mutant.
Zachgo, S.; Silva, E de A; Motte, Patrick ULg et al

in Development (1995), 121(9), 2861-75

Flowers of the temperature-sensitive DEFICIENS (DEF) mutant, def-101, display sepaloid petals and carpelloid stamens when grown at 26 degrees C, the non-permissive temperature. In contrast, when ... [more ▼]

Flowers of the temperature-sensitive DEFICIENS (DEF) mutant, def-101, display sepaloid petals and carpelloid stamens when grown at 26 degrees C, the non-permissive temperature. In contrast, when cultivated under permissive conditions at 15 degrees C, the morphology of def-101 flowers resembles that of the wild type. Temperature shift experiments during early and late phases of flower development revealed that second and third whorl organ development is differentially sensitive to changes in DEF expression. In addition, early DEF expression seems to control the spatially correct initiation of fourth whorl organ development. Reduction of the def-101 gene dosage differentially affects organogenesis in adjacent whorls: at the lower temperature development of petals in the second whorl and initiation of carpels in the centre of the flower is not affected while third whorl organogenesis follows the mutant (carpelloid) pattern. The possible contribution of accessory factors to organ-specific DEF functions is discussed. In situ analyses of mRNA and protein expression patterns during def-101 flower development at 15 degrees C and at 26 degrees C support previously proposed combinatorial regulatory interactions between the MADS-box proteins DEF and GLOBOSA (GLO), and provide evidence that the autoregulatory control of DEF and GLO expression by the DEF/GLO heterodimer starts after initiation of all organ primordia. Immunolocalisation revealed that both proteins are located in the nucleus. Interestingly, higher growth temperature affects the stability of both the DEF-101 and GLO proteins in vivo. In vitro DNA binding studies suggest that the temperature sensitivity of the def-101 mutant is due to an altered heterodimerisation/DNA-binding capability of the DEF-101 protein, conditioned by the deletion of one amino acid within the K-box, a protein region thought to be involved in protein-protein interaction. In addition, we introduce a mutant allele of GLO, glo-confusa, where insertion of one amino acid impairs the hydrophobic carboxy-terminal region of the MADS-box, but which confers no strong phenotypic changes to the flower. The strong mutant phenotype of flowers of def-101/glo-conf double mutants when grown in the cold represents genetic evidence for heterodimerisation between DEF and GLO in vivo. The potential to dissect structural and functional domains of MADS-box transcription factors is discussed. [less ▲]

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See detailMise au point d’une classification automatique des cartes synoptiques d’altitude et application à l’étude des incendies de forêts
Mabille, Georges; Geron, Jean-Marc; Funcken, Philippe et al

in Publication Association Internationale de Climatologie (1995), 8

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See detailTémoignages de la spiritualité néolithique au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailCarte des sols de Belgique et SIG : un traitement préalable visant à la concordance géométrique
Lejeune, Philippe ULg

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30(4), 339-351

Almost half (40 %) of the sheets of the Belgian Soil Map (scale 1/20,000) has been produced on a topographical background showing geometrical differences, sometimes important, with the basic topographic ... [more ▼]

Almost half (40 %) of the sheets of the Belgian Soil Map (scale 1/20,000) has been produced on a topographical background showing geometrical differences, sometimes important, with the basic topographic background produced at present by the National Institute of Geography. Twenty percent of control points georeferenced on a test sheet show differences higher than 80 meters between the two reference systems. A simple method is proposed to match up inaccurate sheets of the soil map with the basic topographic background and to reduce these differences. It is based on control points evenly distributed on the sheet to be corrected and georeferenced in the two systems. A translation is applied to the poiints digitised on the soil map, corresponding to a weighed mean of the differences observed on the nearest control points, the weighing factor being computed on the basis of distances between control points and the element to be corrected. This procedure is integrated in a program running on a PC in Arc/Info environment. The entire correction process (identification of control points, preparation of files, program execution) takes less than three hours per sheet. [less ▲]

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See detailSCALING HYPOTHESIS FOR CORRECTIONS TO TOTAL-ENERGY AND STRESS IN PLANE-WAVE-BASED AB-INITIO CALCULATIONS
RIGNANESE, G. M.; Ghosez, Philippe ULg; CHARLIER, J. C. et al

in Physical Review. B : Condensed Matter (1995), 52(11), 8160-8178

We present a technique aimed at preventing plane-wave-based total energy and stress calculations from the effect of abrupt changes in basis set size. This scheme relies on the interpolation of energy as a ... [more ▼]

We present a technique aimed at preventing plane-wave-based total energy and stress calculations from the effect of abrupt changes in basis set size. This scheme relies on the interpolation of energy as a function of the number of plane waves and on a scaling hypothesis that allows us to perform the interpolation for a unique reference volume. From a theoretical point of view, the method is compared to those already proposed in the literature, and its more rigorous derivation is emphasized. From a practical point of view, we illustrate the importance of the correction on different materials (Si, BaTiO3, and He) corresponding to different types of bonding, and to different k-point samplings and cutoff energies. Then, we compare the different approaches for the calculation of a(0), B-0, and B-0' in bulk silicon. [less ▲]

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See detailVarious persistency measures and relationships with total, partial and peak milk yields
Gengler, Nicolas ULg; Keown, J. F.; VanVleck, L. D.

in Revista Brasileira De Genetica (1995), 18(2), 237-243

Seven persistency measures and their relationships with total, partial and peak yields were studied. Heritabilities, genetic and phenotypic correlations were estimated using mixed model equations with ... [more ▼]

Seven persistency measures and their relationships with total, partial and peak yields were studied. Heritabilities, genetic and phenotypic correlations were estimated using mixed model equations with multiple trait restricted maximum likelihood (REML). Data were from 31,482 first lactation Belgian Holstein-Friesian cows. Differences in direction and size of the correlations between measures of persistency and total yield were found. Two types of measures were used. Persistency measures based on ratio showed positive correlations to total yield. Measures based on standard deviations of test, days or partial yields were correlated negatively with total yield. Correlations with partial yields also showed a similar pattern. Genetic correlations between ratio methods and peak yield were positive. Ratio methods not only describe persistency, but are highly influenced by total yield. Methods using standard deviations of test day yields showed a similar problem, but the influence of the level of total production was negative. Heritabilities of several persistency measures were above 0.10. After considering those results, a newly defined method, based on the standard deviation of partial yields, emerged as the best choice to describe persistency and for use in genetic evaluation of persistency. [less ▲]

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See detailThe continuum of cytokine involvement in the physiology of reproduction
Geenen, Vincent ULg; Hazee, Marie-Thérèse ULg; Goxe, Béatrice et al

in GENESIS (1995), 14

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See detailSimulation of Square Cup Deep Drawing with Different Finite Elements
Kaiping, Li; Habraken, Anne ULg; Bruneel, H.

in Journal of Materials Processing Technology (1995), 50(1-4), 81-91

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See detailPyoverdine-mediated uptake of iron in Pseudomonas putida BTP1 : involvement of a 100 KD IROMP.
Delfosse, Ph; Ongena, Marc ULg; Jacques, Ph et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995), 103(B39),

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See detailHet is nooit goed. Marginalia bij De pasvorm van de goede smaak van Marc Reynebeau
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(3-4), 111-121

This article criticizes the illusions of normative literary criticism, which hopes to determine 'once and for all' the true and objective value of literature.

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See detailFamilial trends of obesity through three generations: the Belgian-Luxembourg child study.
Guillaume, Michèle ULg; Lapidus, L.; Beckers, F. et al

in International Journal of Obesity (1995), 19 Suppl 3

Province de Luxembourg in Belgium is an area with clustering of obesity as well as other risk factors for cardiovascular diseases and non-insulin dependent diabetes mellitus. In this study, obesity was ... [more ▼]

Province de Luxembourg in Belgium is an area with clustering of obesity as well as other risk factors for cardiovascular diseases and non-insulin dependent diabetes mellitus. In this study, obesity was studied in a total of 1028 boys and girls in age-strata 6-8, 8-10, 10-12 years, selected at random from school classes. Participation rate was about 70%. Non-participants did not differ from participants in comparisons of school records of height and weight. Furthermore, information on birth weight, parents' height and weight was collected, as well as reported problems of obesity in grandparents. The results show a high prevalence of pronounced obesity in these children. BMIs were strongly correlated between the children and both parents. Furthermore, grandparents' obesity problems were related to the BMI of parents, and also to obesity indices in the children. Birth weights were related to current BMI of the children (in girls only for the youngest age-group), and to their mothers' BMI. It was concluded that obesity is prevalent in this area and can be traced through three generations, and seems to be discoverable already at birth. Energy intake is high and physical activity level is low in these children. However, statistical analyses suggest that familial factors exert a greater impact than environmental factors on the BMI of the children. These results, as well as the wide-spread, consistent familial clustering of obesity, traceable already at birth, suggest influence of strong genetic traits for obesity in this population. [less ▲]

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See detailNumerical simulation of a full scale fire test on a loaded steel framework
Franssen, Jean-Marc ULg; Cooke, C. M. E.; Latham, D. J.

in Journal of Constructional Steel Research (1995), 35

A single bay single storey steel portal frame has been tested under fire conditions. It is here simulated using hte non linear computer code CEFICOSS. The elements have composite steel-concrete sections ... [more ▼]

A single bay single storey steel portal frame has been tested under fire conditions. It is here simulated using hte non linear computer code CEFICOSS. The elements have composite steel-concrete sections for the thermal analysis, but only the steel part of the sections is load bearing. [less ▲]

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See detailCeci est mon corps. Een inleiding
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5), 4-10

This is an introduction to a special issue on the body in art and literature.

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See detailLa gestion en temps réel des opérations relatives à l’exploitation du trafic fluvial
Marchal, Jean ULg; Hage, André ULg; Rodriguez, S.

in Bulletin de l'Association Technique Maritime et Aéronautique (1995)

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See detailGerminal Center T Cells: Analysis of Their Proliferative Capacity
Bouzahzah, F.; Bosseloir, A.; Heinen, Ernst ULg et al

in Advances in Experimental Medicine and Biology (1995), 378

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See detailEvaluation patrimoniale des droits à la pension en Belgique
Bouillot, L.; Perelman, Sergio ULg

in Revue Belge de Sécurité Sociale (1995)

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See detailGalectin-3, a Laminin Binding Protein, Fails to Modulate Adhesion of Human Melanoma Cells to Laminin
van den Brule, F. A.; Buicu, C.; Sobel, M. E. et al

in Neoplasma (1995), 42(5), 215-9

Galectin-3 is a laminin binding protein which expression is altered in a variety of human carcinomas including colon, breast and endometrium. In these tumors, we consistently observed a down regulation of ... [more ▼]

Galectin-3 is a laminin binding protein which expression is altered in a variety of human carcinomas including colon, breast and endometrium. In these tumors, we consistently observed a down regulation of galectin-3 expression related to increased aggressiveness. Galectin-3 belongs to a family of galactose-binding lectins and binds laminin through its numerous poly-N-acetyllactosamine chains. To date, the exact role of galectin-3 in the complex interactions between cancer cells and laminin has not been clearly defined. Adhesion of melanoma cells to laminin is a critical event during tumor invasion and metastasis. In this study, we explore the possibility that galectin-3 could modulate attachment of two human melanoma cell lines to laminin. A2058 and A375 melanoma cell expressed galectin-3 on their surface as demonstrated by immunofluorescence, and attached to laminin in an in vitro assay. We demonstrate that neither recombinant galectin-3 nor an affinity purified antigalectin-3 antiserum altered adhesion of A2058 or A375 melanoma cells to laminin. Our data strongly suggest that galectin-3 is not a key element in adhesion of the melanoma cells to laminin. These results are not surprising in light of the observation that galectin-3 expression is down regulated in cancer and that increased adhesion to laminin is a constant feature of invasive cancer cells. [less ▲]

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See detailCancers épithéliaux de l'ovaire. Acquisitions récentes
van den Brule, F. A.; Lambotte, René ULg; Castronovo, Vincenzo ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1995), 24(3), 241-52

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by ... [more ▼]

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by the lack of a well defined precursor lesion, the lack of knowledge about tumour progression, and by the relative inaccessibility of the ovaries in the abdominal cavity. Recent studies using experimental models allow us to better define the fundamental mechanisms of carcinogenesis from the serous ovarian cells and of invasion of the abdominopelvic cavity by proximity. This review article tries to update on epidemiology, genetic syndromes, biology, screening, and therapy of these epithelial tumours, and about the new directions taken by basic and clinical research. We will present data concerning oncogenes and tumour suppressor genes involved in epithelial ovarian tumours, regulation of tumour cells by growth factors, genes involved in tumour invasion, and mechanisms used by the cancer cell to resist to therapies. Non-epithelial ovarian tumours will not be examined in this manuscript. [less ▲]

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See detailTwo forms of lipase from Mucor miehei exhibit a different behavior at the air-water interface.
Blecker, Christophe ULg; Razafindralambo, Hary ULg; Paquot, Michel ULg et al

in Colloids and Surfaces B : Biointerfaces (1995), (3), 271-279

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See detailLe méthotrexate en rhumatologie: une révolution thérapeutique
Kaye, O.; Ribbens, Clio ULg; Hauwaert, Christian ULg et al

in Revue Médicale de Liège (1995), 50(11), 453-457

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See detailProductivité et efficacité dans l'assurance
Fecher-Bourgeois, Fabienne ULg; Pestieau, Pierre ULg

in Risques - Les Cahiers de l'assurance (1995), 22(Avril-juin 1995), 65-71

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See detailComment j'explore... Une anemie (1e partie).
Beguin, Yves ULg

in Revue Médicale de Liège (1995), 50(10), 443-4

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See detailDe Karmelietenkerk in Gent, Dendrochronologische analyse van de dakconstructie boven tweede beuk
Hoffsummer, Patrick ULg; Houbrechts, David

in Stadsarcheologie (1995), 18(2),

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See detailCryptocrine Signaling in the Thymus Network and T Cell Education to Neuroendocrine Self-Antigens
Geenen, Vincent ULg; Goxe, Béatrice; Martens, Henri ULg et al

in Journal of Molecular Medicine : Official Organ of the 'Gesellschaft Deutscher Naturforscher und Ärzte' (1995), 73(9), 449-55

Both during phylogeny and ontogeny the thymus appears as a nodal point between the two major systems of cell-to-cell signaling, the neuroendocrine and immune systems. This review presents the experimental ... [more ▼]

Both during phylogeny and ontogeny the thymus appears as a nodal point between the two major systems of cell-to-cell signaling, the neuroendocrine and immune systems. This review presents the experimental observations which support a dual role in T cell selection played by the thymic repertoire of neuroendocrine polypeptide precursors. Through the mode of cryptocrine intercellular signaling thymic neuroendocrine-related precursors synthesized in thymic epithelial cells have been shown to influence the early steps in T cell differentiation. In addition, thymic neuroendocrine-related polypeptides are a source of self-antigens which are presented by the major histocompatibility system of the thymic epithelium. Preliminary data also suggest that the intrathymic T cell education to neuroendocrine self-antigens is not strictly superimposible to the antigen presentation by dedicated presenting cells. Insulin-like growth factor-II (IGF-II) was identified as one dominant member of the insulin family expressed by thymic epithelial and nurse cells. The intrathymic presentation of IGF-II or IGF-II derived self-antigens is under current investigation. If further confirmed, the central tolerogenic properties of IGF-II could be considered in the elaboration of a strategy for an efficient and safe prevention of insulin-dependent diabetes. [less ▲]

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See detailLow-dose methotrexate: an effective corticosteroid-sparing agent in the musculoskeletal manifestations of sarcoidosis
Kaye, O.; Palazzo, E.; Grossin, M. et al

in British Journal of Rheumatology (1995), 34(7), 642-644

Extrapulmonary sarcoidosis, and particularly the presence of musculoskeletal complications of the disease, may require chronic corticosteroid therapy. In five patients with biopsy-proven sarcoidosis and ... [more ▼]

Extrapulmonary sarcoidosis, and particularly the presence of musculoskeletal complications of the disease, may require chronic corticosteroid therapy. In five patients with biopsy-proven sarcoidosis and presenting recalcitrant forms of the disease, we introduced low-dose oral methotrexate (MTX) [10 mg/week (7.5-15)] for 30 months (16-34) to control the clinical and biological symptoms as well as to try to reduce the intolerated steroid posology. Beneficial effects were observed within 8-12 weeks in all patients, which allowed a reduction of 59% (35-75) of the corticosteroid posology, and maintained with a follow-up of 3 yr in 4/5 patients. No significant toxicity was observed. MTX appears to be an efficient, safe and corticosteroid-sparing therapeutic agent for the treatment of recalcitrant musculoskeletal manifestations of sarcoidosis. [less ▲]

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See detailSpecific bovine brucellosis diagnosis based on in vitro antigen-specific gamma interferon production.
Weynants, V.; Godfroid, J.; Limbourg, B. et al

in Journal of Clinical Microbiology (1995), 33(3), 706-12

In order to improve the specificity of the diagnosis of bovine brucellosis, we developed a test which can be regarded as an in vitro correlate of the delayed-type hypersensitivity test (DTH). A mixture of ... [more ▼]

In order to improve the specificity of the diagnosis of bovine brucellosis, we developed a test which can be regarded as an in vitro correlate of the delayed-type hypersensitivity test (DTH). A mixture of cytoplasmic proteins from Brucella melitensis B115 was used as a specific antigenic stimulus in bovine whole blood culture. Supernatants harvested at 18 to 24 h after the in vitro antigenic stimulus were assayed for their gamma interferon (IFN-gamma) content by using a commercial sandwich enzyme-linked immunosorbent assay kit. The IFN-gamma assay was evaluated with 10 heifers during the course (80 days) of an experimental infection and with 14 cows from an ongoing brucellosis outbreak. All of these animals were slaughtered, and pertinent organs were subjected to classical bacteriological analyses. In addition, we analyzed 23 field cases in which false-positive serological reactions occurred. The IFN-gamma results were compared with those of the standard DTH and a battery of serological assays, and they were correlated with bacteriological data. Both for the experimental infection and for the field brucellosis outbreak, the IFN-gamma assay detected infection in more animals than any combination of the serological tests, and it detected infection earlier than these tests. Finally, none of the samples from cows showing false-positive serological reactions was classified as positive by the IFN-gamma assay, attesting to its specificity and to its usefulness in interpreting ambiguous serological results. A rapid and convenient alternative to the DTH, the IFN-gamma assay appears to be an ideal method that is complementary to the serological diagnosis protocols. [less ▲]

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See detailLa naissance de l'écriture au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailThiamine Deficiency in Cultured Neuroblastoma Cells: Effect on Mitochondrial Function and Peripheral Benzodiazepine Receptors
Bettendorff, Lucien ULg; Goessens, Guy ULg; Sluse, Francis ULg et al

in Journal of Neurochemistry (1995), 64(5), 2013-2021

When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days. Respiration and ATP levels ... [more ▼]

When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days. Respiration and ATP levels were only slightly affected, but addition of a thiamine transport inhibitor (amprolium) decreased ATP content and increased lactate production. Oxygen consumption became low and insensitive to oligomycin and uncouplers. At least 25% of mitochondria were swollen and electron translucent. Cell mortality increased to 75% within 5 days. [3H]PK 11195, a specific ligand of peripheral benzodiazepine receptors (located in the outer mitochondrial membrane) binds to the cells with high affinity (KD = 1.4 +/- 0.2 nM). Thiamine deficiency leads to an increase in both Bmax and KD. Changes in binding parameters for peripheral benzodiazepine receptors may be related to structural or permeability changes in mitochondrial outer membranes. In addition to the high-affinity (nanomolar range) binding site for peripheral benzodiazepine ligands, there is a low-affinity (micromolar range) saturable binding for PK 11195. At micromolar concentrations, peripheral benzodiazepines inhibit thiamine uptake by the cells. Altogether, our results suggest that impairment of oxidative metabolism, followed by mitochondrial swelling and disorganization of cristae, is the main cause of cell mortality in severely thiamine-deficient neuroblastoma cells. [less ▲]

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See detailCharacteristics of the pulsatile liberation of LH in Italian Simmental cows from the dry period to early lactation
Prandi, Alberto; Motta, Mario; Rossi, A. et al

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30

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See detailNF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression.
Drew, P. D.; Franzoso, G.; Becker, K. G. et al

in Journal of Interferon & Cytokine Research (1995), 15(12), 1037-45

Major histocompatibility (MHC) class I gene expression is synergistically induced by the cytokines TNF-alpha and IFN-gamma. However, the mechanism that results in synergistic activation of these genes has ... [more ▼]

Major histocompatibility (MHC) class I gene expression is synergistically induced by the cytokines TNF-alpha and IFN-gamma. However, the mechanism that results in synergistic activation of these genes has remained unclear. We demonstrated here that TNF-alpha induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence (ICS). We further demonstrated that NF kappa B and IRF-1 physically interacted with each other and cooperatively induced MHC class I gene expression when cotransfected into CHP-126 neuroblastomas. These results provide a molecular mechanism by which TNF-alpha and IFN-gamma synergistically induce the expression of a variety of genes involved in immune responses, including MHC class I. [less ▲]

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See detailLaparoscopic Intrauterine Insemination in the Bitch
Silva, L. D.; Onclin, K.; Snaps, Frédéric ULg et al

in Theriogenology (1995), 43(3), 615-23

A technique for laparoscopic intrauterine insemination in bitches is described. During natural estrus, 5 beagle bitches were inseminated and S others were naturally mated (control group) twice at a 48-h ... [more ▼]

A technique for laparoscopic intrauterine insemination in bitches is described. During natural estrus, 5 beagle bitches were inseminated and S others were naturally mated (control group) twice at a 48-h interval on Days 3 and S (n = 4) or Days 4 and 6 (n = 6) after the increase in plasma progesterone considered to be indicative of the day of the preovulatory LH peak. All the inseminations were with fresh semen and under general anesthesia. The technique involved the introductions of 1) a Verres needle to insufflate the abdominal cavity by direct punction on the middle line 1 cm over the umbilicus, 2) a laparoscope to visualize the abdominal cavity by a 1 cm puncture on the middle line 1 cm under the umbilicus, 3) a forceps used to manipulate the uterus by a 0.5 cm puncture at 2 to 3 cm lateral to the mammary glands, and 4) an 18-g catheter used to puncture the uterus on the middle line between the 3rd and 5th mammary gland. The uterine body was grasped by the forceps and elevated against the ventral abdominal wall. The 18-g catheter was then inserted through the abdominal wall directly into the uterine lumen, and 1.0 ml of fresh semen containing 250 to 480 x 10(6) spermatozoa/ml was injected. The inseminations resulted in pregnancies in all animals. Litter size was similar in the artificially inseminated and naturally mated bitches (5 +/- 1.8 and 4.8 +/- 1.6 pups per litter, respectively). Bitches in the artificially inseminated group delivered at 65.2 +/- 0.8 d and in the natural mated group at 65.4 +/- 0.5 d after the LH peak. In conclusion, this paper gives the first results of intrauterine laparoscopic insemination in bitches, indicating interesting perspectives for this technique in dog's reproduction. [less ▲]

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See detailA Propos de la Physique du Ruissellement sur Bassin Versant
Pirotton, Michel ULg

in Tribune de l'Eau (La) (1995), 48(573), 3-10

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See detailThe Yxxl Signaling Motifs Of The Bovine Leukemia-Virus Transmembrane Protein Are Required For In-Vivo Infection And Maintenance Of High Viral Loads
Willems, Luc ULg; Gatot, Js.; Mammerickx, M. et al

in Journal of Virology (1995), 69(7),

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See detailThe pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain.
Peers, Bernard ULg; Sharma, S.; Johnson, T. et al

in Molecular & Cellular Biology (1995), 15(12), 7091-7

A number of homeodomain proteins have been shown to regulate cellular development by stimulating the transcription of specific target genes. In contrast to their distinct activities in vivo, however, most ... [more ▼]

A number of homeodomain proteins have been shown to regulate cellular development by stimulating the transcription of specific target genes. In contrast to their distinct activities in vivo, however, most homeodomain proteins bind indiscriminately to potential target sites in vitro, suggesting the involvement of cofactors which specify target site selection. One such cofactor, termed extradenticle, has been shown to influence segmental morphogenesis in Drosophila melanogaster by binding cooperatively with certain homeodomain proteins to target regulatory elements. Here we demonstrate that STF-1, an orphan homeodomain protein required for pancreatic development in mammals, binds cooperatively to DNA with Pbx, the mammalian homolog of extradenticle. Cooperative binding with Pbx requires a pentapeptide motif (FPWMK) which is well conserved among a large subset of homeodomain proteins. The FPMWK motif is not sufficient to confer Pbx cooperativity on other homeodomain proteins, however; the N-terminal arm of the STF-1 homeodomain is also essential. As cooperative binding with Pbx occurs on only a subset of potential STF-1 target sites, our results suggest that Pbx may specify target gene selection in the developing pancreas by forming heterodimeric complexes with STF-1. [less ▲]

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See detailBiology and clinical uses of erythropoietin in infants and children
Beguin, Yves ULg

in International Journal of Pediatric Hematology/Oncology (1995), 2

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See detailExperimental production of hypocalcemia by EDTA infusion in calves : a critical appraisal assessed from the profile of blood chemicals and enzymes
Desmecht, Daniel ULg; Linden, Annick ULg; Godeau, J. M. et al

in Comparative Biochemistry and Physiology. A : Comparative Physiology (1995), 110A(2), 115-130

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See detailAssessment of equine diaphragm strength and activation using transvenous phrenic nerve stimulation
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1995), 18

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See detailTEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant.
Fonze, E.; Charlier, Paulette ULg; To'th, Y. et al

in Acta Crystallographica Section D-Biological Crystallography (1995), 51(Pt 5), 682-94

beta-Lactamases are bacterial enzymes which catalyse the hydrolysis of the beta-lactam ring of penicillins, cephalosporins and related compounds, thus inactivating these antibiotics. The crystal structure ... [more ▼]

beta-Lactamases are bacterial enzymes which catalyse the hydrolysis of the beta-lactam ring of penicillins, cephalosporins and related compounds, thus inactivating these antibiotics. The crystal structure of the TEM1 beta-lactamase has been determined at 1.9 A resolution by the molecular-replacement method, using the atomic coordinates of two homologous beta-lactamase refined structures which show about 36% strict identity in their amino-acid sequences and 1.96 A r.m.s. deviation between equivalent Calpha atoms. The TEM1 enzyme crystallizes in space group P2(1)2(1)2(1) and there is one molecule per asymmetric unit. The structure was refined by simulated annealing to an R-factor of 15.6% for 15 086 reflections with I >/= 2sigma(I) in the resolution range 5.0-1.9 A. The final crystallographic structure contains 263 amino-acid residues, one sulfate anion in the catalytic cleft and 135 water molecules per asymmetric unit. The folding is very similar to that of the other known class A beta-lactamases. It consists of two domains, the first is formed by a five-stranded beta-sheet covered by three alpha-helices on one face and one alpha-helix on the other, the second domain contains mainly alpha-helices. The catalytic cleft is located at the interface between the two domains. We also report the crystallographic study of the TEM S235A mutant. This mutation of an active-site residue specifically decreases the acylation rate of cephalosporins. This TEM S235A mutant crystallizes under the same conditions as the wild-type protein and its structure was refined at 2.0 A resolution with an R value of 17.6%. The major modification is the appearance of a water molecule near the mutated residue, which is incompatible with the OG 235 present in the wild-type enzyme, and causes very small perturbations in the interaction network in the active site. [less ▲]

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See detailCharles Grandgagnage (Liège 1812-Liège 1878)
Boutier, Marie-Guy ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (1995), (4), 4

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See detailSoya oil in diet for growing-fattening bulls: I. Effects on animal performances and carcass composition
Clinquart, Antoine ULg; Van Eenaeme, Christian ULg; Dufrasne, Isabelle ULg et al

in Journal of Animal Physiology & Animal Nutrition (1995), 74

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See detailExtracellular matrix proteins and basement membrane identification in bovine ovaries and significance for the attachment of cultured preantral follicles
Figueiredo, J. R.; Hulshof, S. C. J.; Thiry, Marc ULg et al

in Theriogenology (1995), 43(5), 845-858

Described in the present paper is the immunolocalization of the extracellular matrix proteins (e.g., fibronectin, collagen Types I and III) in the bovine ovary, with special attention to preantral ... [more ▼]

Described in the present paper is the immunolocalization of the extracellular matrix proteins (e.g., fibronectin, collagen Types I and III) in the bovine ovary, with special attention to preantral follicles. In addition, we have shown, histochemically and ultrastructurally, that mechanically isolated bovine preantral follicles are surrounded by an intact basement membrane. After 24 h of culture in serum-free medium, only 20.4% of these follicles attached to a plastic substrate. We showed that covering the plastic with extracellular matrix proteins (i.e., fibronectin, collagen Type I and matrigel) significantly increased the percentage of attached follicles to 76.0, 65.2 and 80.4%, respectively, while laminin had no effect (18.6%). When preantral follicles were embedded within three-dimensional collagen gels, no loss of follicles was observed. Restoring surface interactions between preantral follicles and the extracellular matrix in vitro, either in a two- or a three-dimensional system, might be important for maintaining follicular viability and growth in the future. [less ▲]

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See detailKozani-Grevena Earthquake and the Active tectonics of Northern Greece
Meyer, B.; Armijo, R.; Hubert, Aurelia ULg et al

Scientific journal (1995)

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See detailÉvaluation de l’impact de la végétation sur le rayonnement énergétique (aide à la conception architecturale et urbanistique)
Teller, Jacques ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailINTERVALENCE TRANSITIONS IN MIXED-VALENCE BIS(TETRATHIAFULVALENE) COMPOUNDS
Lahlil, Khalid; Moradpour, Alec; Bowlas, Christopher et al

in Journal of the American Chemical Society (1995), 117(40), 9995-10002

The series of new bis(tetrathiafulvalene) [bis(TTF)] compounds 10-12a,b have been synthetized with the TTF-like synthon 8a,b, previously used to prepare the pyrazine-fused bis(TTF) 7a,b. These compounds ... [more ▼]

The series of new bis(tetrathiafulvalene) [bis(TTF)] compounds 10-12a,b have been synthetized with the TTF-like synthon 8a,b, previously used to prepare the pyrazine-fused bis(TTF) 7a,b. These compounds exhibit four reversible sequential one-electron oxidation steps, on the basis of cyclic voltammetry. For the cation radicals 7b(.+), 10(.+), and 12(.+), generated electrochemically, rather intense and broad bands in the near-IR region, specific of class II mixed valence compounds, were found. Theoretical calculations at the semiempirical AM1 level as well as at the ab-initio level indicated that these cation radicals are charge-distributions localized as related to mixed valence species. These calculations also allowed the low-energy absorption bands to be assigned to intervalence transitions; these transitions imply the existence of multiple low-lying excited states that are non-adiabatically coupled to the ground-state of these open-shell species. [less ▲]

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See detailAmylin/islet amyloid polypeptide: biochemistry, physiology, patho-physiology.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Diabète & Métabolisme (1995), 21(1), 3-25

Amylin is a 37 amino-acid peptide mainly produced by the islet beta-cell. Aggregation of amylin is partly responsible for amyloid formation. Amyloid deposits occur both extracellularly and intracellularly ... [more ▼]

Amylin is a 37 amino-acid peptide mainly produced by the islet beta-cell. Aggregation of amylin is partly responsible for amyloid formation. Amyloid deposits occur both extracellularly and intracellularly and may contribute to beta-cell degeneration. Amylin is packed in beta-cell granules and cosecreted with insulin in response to the same stimuli but, unlike other beta-cell products, it is produced from specific a gene on chromosome 12. Basal, plasma amylin concentrations are around 5 pM, and increase fourfold after meals or glucose. Higher levels are found in cases of insulin resistance, obesity, gestational diabetes and in some patients with NIDDM. Low or absent levels are found in insulin-dependent diabetic patients. There are similarities between amylin and non beta-cell peptides such as calcitonin gene related peptides (CGRP). They may bind to the same receptor, determine similar post-receptor phenomena and qualitatively similar actions but with different degree of potency. The actions of amylin are multiple and mostly exerted in the regulation of fuel metabolism. In muscle, amylin opposes glycogen synthesis, activates glycogenolysis and glycolysis (increasing lactate production). Consequently, amylin increases lactate output by muscle and increases the plasma lactate concentration. In fasting conditions, this lactate may serve as a gluconeogenic substrate for the liver, contributing to replenish depleted glycogen stores and to increase glucose production. In non-fasting conditions, lactate can be transformed by liver in triglycerides. It is not clear at present whether amylin actions on the liver are direct or mediated by changes in circulating metabolites. A probably indirect effect of amylin in muscle is to decrease insulin- (or glucose)-induced glucose uptake, which may contribute to insulin resistance. Other actions include inhibition of glucose-stimulated insulin secretion and, in general, actions mimicking CGRP effects. Some of these actions are seen at supraphysiological concentrations. The physiopathological consequences of amylin deficiency, or excess are under active by investigated. [less ▲]

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See detail11-(4-methylpiperazin-1-yl)-5H-pyrido[4,3-b][1,5]benzodiazepine
Dupont, L.; Liégeois, Jean-François ULg; Rogister, F. et al

in Acta Crystallographica Section C-Crystal Structure Communications (1995), C51

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See detailMeasurement of glucosinolates in rapeseeds.
Wathelet, Jean-Paul ULg; Marlier, M.; Severin, M. et al

in Natural toxins (1995), 3(4),

Several ring tests have been organized by the International Organisotion for Standardization (lSO) and the Measurement ônd Testing Programme (BCR) for improving glucosinolote methods Finally, HPLC of ... [more ▼]

Several ring tests have been organized by the International Organisotion for Standardization (lSO) and the Measurement ônd Testing Programme (BCR) for improving glucosinolote methods Finally, HPLC of desulphoglucosinolates is recommended by lSO, the European Committee for Standardizotion (CEN), and the European Commission (EC) as the official method. X-ray fluorescence has also become particularly common for fast analysis. After checking stability of intact glucosinolates in whole rapeseeds, the BCR has three reference materials (CRM 366, CRM 190, CRM 367) avai able, certified for their total glucosinolate and sulphur contents. Currently, the Measurement and Testing Programme is supporting a research project concerning the stdbility of desulphoglucosinolates and intact glucosinolates extracts. At the present time, best results were observed with lyophilized extracts sealed in brown glass ampoules and stored at 18'C. [less ▲]

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See detailL'axe sol-plante-animal dans les tétanies d'herbe
Dufrasne, Isabelle ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1995), 139

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See detailRacism and Migration in Western Europe de J. Wrench et J. Solomos (eds.)
Martiniello, Marco ULg

in International Migration Review (1995), 24(4), 1074-1075

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See detailExogenous glucose oxidation during exercise in relation to the power output.
Pirnay, Freddy ULg; Scheen, André ULg; Gautier, J. F. et al

in International Journal of Sports Medicine (1995), 16(7), 456-60

In order to study the influence of the power output on the oxidation rate of exogenous glucose and on the contribution of the various substrates to the energy demand, we combined the use of artificially ... [more ▼]

In order to study the influence of the power output on the oxidation rate of exogenous glucose and on the contribution of the various substrates to the energy demand, we combined the use of artificially enriched 13C-glucose with classical indirect calorimetry during uphill treadmill exercise. Six young male healthy subjects underwent three exercise bouts, in a randomized order and at least two weeks apart, at a low (45% VO2max, 1822 +/- 194 ml O2/min for 4 hours), moderate (60% VO2max, 2582 +/- 226 ml O2/min for 3 hours), and high intensity (75% VO2max, 3036 +/- 287 ml O2/min for 2 hours). After 10 min of exercise, each subject ingested 100 g of artificially 13C-labelled glucose dissolved in 400 ml of water. Over the four hours of the exercise at 45% VO2max, the amount of exogenous glucose oxidized was 89.5 +/- 5.9 g from the 100 g ingested. In all exercise bouts, the oxidation of exogenous glucose already began during the first 30 min after ingestion and peaked at 120 min. The maximum oxidation rates averaged 0.64 +/- 0.07, 0.75 +/- 0.04, and 0.63 +/- 0.08 g/min, and the mean amounts of exogenous glucose oxidized over the first two hours averaged 51.7 +/- 8.0, 61.5 +/- 6.6 and 50.9 +/- 8.45 g, at 45, 60 and 75% VO2max respectively. The contribution of the oxidation of exogenous glucose to the total energy supply progressively decreased when the power output increased, from 19.6 to 12.2%. In the meantime, the contribution of total carbohydrates (exogenous+endogenous) progressively increased from 55.1 to 77.8% while the contribution of lipids decreased from 35.5 to 16.6%. In conclusion, exogenous glucose ingested during exercise is largely oxidized and strongly contributes to the energy supply. The oxidation rate first increases with the power output, but levels off or even decreases at high intensity exercise. [less ▲]

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See detailEffectiveness of a video training programme used to improve error identification and feedback processes by physical education student teachers
Cloes, Marc ULg; Premuzak, Jean

in International Journal of Physical Education (1995), 32(3), 4-10

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See detailLes fondements de l'analyse numérique de photos prises au fisheye pour des besoins topoclimatologiques
Cornélis, Bernard ULg; Erpicum, Michel ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

Fisheye pictures are frequently used in forestry and in ecology for canopy measurements. In climatology, it seems that they have only been used for illustration purposes. In fact, fisheye pictures are ... [more ▼]

Fisheye pictures are frequently used in forestry and in ecology for canopy measurements. In climatology, it seems that they have only been used for illustration purposes. In fact, fisheye pictures are rich in climatological information. Digital fisheye image processing can be used for applied climatology as well as for topoclimatological studies. It allows the quantification of insolation, diffuse radiation, sky-view factor,.… In other words, it provides an objective assessment of the exposure of a site or of a measuring device. This article introduces the basis for digital fisheye image processing. The possibilities offered by this tool will be illustrated with sunshine measurements in an urban environment. [less ▲]

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See detailIn vivo responsiveness of morphological variants of growth hormone-producing pituitary adenomas to octreotide
Ezzat, S.; Kontogeorgos, G.; Redelmeier, D. A. et al

in European Journal of Endocrinology (1995), 133

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See detailPharma clinics. Comment je traite ... une anemie (3e partie).
Beguin, Yves ULg

in Revue Médicale de Liège (1995), 50(12), 497-8

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See detailFlux de nitrate dans une zone à nappes superficielles en Wallonie (Belgique)
Demarets, X.; Marcoen, Jean Marie ULg; Agneessens, R. et al

in Cahiers Agricultures (1995), 4

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See detailPost-operative erythropoiesis is limited by the inflammatory effect of surgery on iron metabolism.
Biesma, D. H.; Van de Wiel, A.; Beguin, Yves ULg et al

in European Journal of Clinical Investigation (1995), 25(6), 383-9

The decrease in haemoglobin concentration commonly observed after major surgery is usually corrected by red cell transfusions or oral iron medication. The increased awareness of blood-transmissible ... [more ▼]

The decrease in haemoglobin concentration commonly observed after major surgery is usually corrected by red cell transfusions or oral iron medication. The increased awareness of blood-transmissible diseases has led to the restrictive use of homologous blood and to interest in alternatives for correcting anaemia. We investigated the pathophysiology of postoperative anaemia by studying variables of erythropoiesis, iron metabolism, and inflammation in 48 consecutive patients who underwent total hip replacement. Haemoglobin concentration remained low during 14 days after surgery with only a mild increase in erythropoietin concentration and reticulocyte count. No increase in serum transferrin receptor concentration was observed during the first 2 weeks after surgery. Postoperative serum ferritin increased, whereas serum iron, transferrin and transferrin saturation decreased significantly. There was a marked increase in interleukin-6 and C-reactive protein with maximal values on the 1st and 4th post-operative day, respectively. At 6 weeks after surgery, haemoglobin concentration and variables of iron metabolism were almost at the preoperative level and serum transferrin receptor concentration was significantly increased, indicating increased erythropoietic activity. These changes were preceded by the normalization of interleukin-6 and C-reactive protein levels. Haemoglobin, iron, transferrin, and ferritin concentrations were not influenced by iron therapy during the postoperative period and no differences of erythropoietic and iron variables were observed between transfused and non-transfused patients. In conclusion, post-operative erythropoiesis is associated with an inflammatory effect of surgery on iron metabolism, which can explain, despite a slightly increased production of erythropoietin, the persistence of anaemia and the lack of effect of iron supplementation after surgery. [less ▲]

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See detailBage - A New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-Lymphocytes
Boel, P.; Wildmann, C.; Sensi, Ml. et al

in Immunity (1995), 2(2), 167-75

Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues ... [more ▼]

Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named BAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw 1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy. [less ▲]

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See detailNucleotide sequence of the ovine P53 tumor-suppressor cDNA and its genomic organization.
Dequiedt, Franck ULg; Kettmann, Richard ULg; Burny, A. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1995), 5(4),

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See detailOverexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria.
Van Dyck, E.; Jank, B.; Ragnini, A. et al

in Molecular & General Genetics [=MGG] (1995), 246

The PIF1 and MRS2 gene products have previously been shown to be essential for mitochondrial DNA maintenance at elevated temperatures and mitochondrial group II intron splicing, respectively, in the yeast ... [more ▼]

The PIF1 and MRS2 gene products have previously been shown to be essential for mitochondrial DNA maintenance at elevated temperatures and mitochondrial group II intron splicing, respectively, in the yeast Saccharomyces cerevisiae. A multicopy suppressor capable of rescuing the respiratory deficient phenotype associated with null alleles of either gene has been isolated. This suppressor is a nuclear gene that was called RIM2/MRS12. The RIM2/MRS12 gene encodes a predicted protein of 377 amino acids that is essential for mitochondrial DNA metabolism and proper cell growth. Inactivation of this gene causes the total loss of mitochondrial DNA and, compared to wild-type rhoo controls, a slow-growth phenotype on media containing glucose. Analysis of the RIM2/MRS12 protein sequence suggests that RIM2/MRS12 encodes a novel member of the mitochondrial carrier family. In particular, a typical triplicate structure, where each repeat consists of two putative transmembrane segments separated by a hydrophilic loop, can be deduced from amino acid sequence comparisons and the hydropathy profile of RIM2/MRS12. Antibodies directed against the aminoterminus of RIM2/MRS12 detect this protein in mitochondria. The function of the RIM2/MRS12 protein and the substrates it might transport are discussed. [less ▲]

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See detailEffect of previous antidepressant therapy on the growth hormone response to apomorphine.
Pitchot, William ULg; Hansenne, Michel ULg; Gonzalez Moreno, A. et al

in Neuropsychobiology (1995), 32(1), 19-22

Several lines of evidence suggest a role for dopamine in the pathophysiology of depression. In 1988, we reported a blunted response of growth hormone (GH) to apomorphine, a dopaminergic agonist, in ... [more ▼]

Several lines of evidence suggest a role for dopamine in the pathophysiology of depression. In 1988, we reported a blunted response of growth hormone (GH) to apomorphine, a dopaminergic agonist, in endogenous depression. However, an antidepressant washout period is a major confounding factor in studies assessing the GH response to apomorphine. Indeed, whereas the influence of tricyclic antidepressants on the GH response to apomorphine is presently unknown, several reports have suggested that tricyclics may impair the GH response to clonidine for periods longer than 3 weeks following their discontinuation. In the present study, we hypothesized that a blunted GH response to apomorphine in depressed patients could be related to the recent administration of antidepressants. Therefore, the GH response to apomorphine (0.5 mg) was studied in 11 male DSM-III-R major depressive inpatients who had never received antidepressant therapy (group 1) compared to 11 normal controls and 11 major depressive inpatients drug free for at least 2 weeks (group 2). The three groups differed significantly in the GH peak response to apomorphine: mean (SD) 5.4 (4.0) ng/ml in group 1, 25.5 (10.7) in normal controls, and 5.5 (5.1) in group 2 (F = 15.5, df = 3, 30, p = 0.00001). While group 1 and normal controls (F = 21.8, p = 0.0002) as well as group 2 and controls (F = 5.6, p = 0.03) differed significantly, group 1 and group 2 did not (F = 0.18, p = 0.68). These results suggest that a washout period of 2 weeks could be sufficient in studies assessing the GH response to apomorphine. [less ▲]

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See detailComparison and validation of heat stress indices in experimental studies
Mairiaux, Philippe ULg; Malchaire, Jacques

in Ergonomics (1995), 38(1), 58-72

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See detailStudies On The In-Situ Nitrogen Degradability Corrected For Bacterial-Contamination Of Concentrate Feeds In Steers
Beckers, Yves ULg; Thewis, André ULg; Maudoux, B. et al

in Journal of Animal Science (1995), 73(1), 220-227

Stable 15N was used to evaluate the influence of bacterial contamination on in situ DM and N degradabilities (Dg) of meat and bone meal (MBM), soybean meal (SBM), and wheat bran (WB) in two steers ... [more ▼]

Stable 15N was used to evaluate the influence of bacterial contamination on in situ DM and N degradabilities (Dg) of meat and bone meal (MBM), soybean meal (SBM), and wheat bran (WB) in two steers. Bacterial DM and N contamination ranged from 2.4 to 28.6% and 2.1 to 56.8% of residual DM and N, respectively. Effective N degradability increased when bacterial contamination was taken into account ( P < .05). The difference was low for MBM (2.4%) and for SBM (3.4%) but high for WB (12.2%). Theoretically, using solid-associated bacteria should give the most accurate correction for bacterial contamination; however, results showed that Dg of N based on liquid-associated bacteria were identical for MBM and SBM ( P > .05) and different for WB ( P .05). In a second experiment, five treatments were applied to incubated feeds to remove bacteria fxed to the residues and consequently to determine directly the Dg of DM and N corrected for the bacterial contamination without the need for a marker. These treatments involved chilling for 6 h at 4°C in saline solution alone ( T l ) or with a commercial detergent (T2), or with sodium dodecyl sulfate (T3) or with methylcellulose (T4), followed by pummeling in a stomacher for 5 min. The last treatment was only machine washing twice (T5). The Dg of DM can be directly determined following the first four treatments, nevertheless their application to MBM and SBM led to higher Dg of N than that corrected for the bacterial contamination determined in the frst experiment ( P < .05). This overestimation was higher than the observed underestimation when the correction for bacterial contamination was omitted. However, two treatments (T1 and T4) were able to dislodge bacterial N fixed to incubated WB and so the Dg of N could be measured directly. In conclusion, bacterial contamination of concentrate feeds incubated in the rumen may be extensive. In this case Dg must be corrected for this contamination or treatments for decontamination can be applied to residues before determining the Dg of N. [less ▲]

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See detailRelationship between transfusion regimen and suppression of erythropoiesis in beta-thalassaemia major.
Cazzola, M.; De Stefano, P.; Ponchio, L. et al

in British Journal of Haematology (1995), 89(3), 473-8

In the management of beta-thalassaemia major, different transfusion schemes are employed with baseline haemoglobin levels ranging from 8 to over 12 g/dl. We studied the relationship between transfusion ... [more ▼]

In the management of beta-thalassaemia major, different transfusion schemes are employed with baseline haemoglobin levels ranging from 8 to over 12 g/dl. We studied the relationship between transfusion regimen and suppression of erythropoiesis in 52 patients with beta-thalassaemia major whose mean pretransfusion haemoglobin levels ranged from 8.6 to 10.9 g/dl. Multiple, regression analysis showed that serum transferrin receptor was the parameter more closely related to mean pretransfusion haemoglobin (r = -0.77, P < 0.001). As measured through serum transferrin receptor, erythroid activity was 1-2 times normal for pretransfusion haemoglobin levels between 10 and 11 g/dl. 1-4 times normal for levels from 9 to 10 g/dl, and 2-6 times normal for levels from 8.6 to 9 g/dl. Mean pretransfusion haemoglobin was also inversely related to serum erythropoietin (r = -0.72, P < 0.001), whereas it showed no or a weak relationship with Hb F, reticulocyte count, or circulating nucleated red cell count. This study suggests that serum transferrin receptor is a reliable indicator of suppression of erythropoiesis in beta-thalassaemia major. On the basis of our findings, pretransfusion haemoglobin values of < or = 9 g/dl should be adopted with caution, because these levels can be associated with an insufficient inhibition of erythroid marrow expansion. However, a transfusion programme, with a baseline haemoglobin of 9-10 g/dl, may provide enough suppression of erythropoiesis and allow a reduction in blood consumption as compared with the classic hyper- or supertransfusion schemes. Since fixed haemoglobin levels may not be the best target for transfusion treatment in all thalassaemic patients, assay of serum transferrin receptor may be helpful for individualizing the transfusion regimens. [less ▲]

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See detailEtude de la variabilité interindividuelle des potentiels evoques auditifs exogènes et endogènes en condition d'attention volontaire
Lembreghts, M.; Crasson, Marion ULg; el Ahmadi, A. et al

in Neurophysiologie Clinique = Clinical Neurophysiology (1995), 25(4), 203-23

The use of P300 in psychopathology raises the important problem of the constitution of reference normative data and of the high variability of auditive ERP's in controls. To handle better this problem, we ... [more ▼]

The use of P300 in psychopathology raises the important problem of the constitution of reference normative data and of the high variability of auditive ERP's in controls. To handle better this problem, we recorded 86 control subjects, using an auditory oddball paradigm with motor response. We analyzed the successive components of the ERP's evoked by target and standard stimuli (N1, P2, N2, P3a, P3b and slow wave negativity). Our results underlined the role of age, sex and psychological factors on the ERP's interindividual variability: P3 amplitude decreased and its latency increased with age, while its topography was more frontal in the older than in the younger subjects. The P300 occurrence after standard stimuli and P3 amplitude after target stimuli were different according to sex. Moreover, P300 amplitude, latency and topography were related to the subject's anxiety level. Finally, our results also propose new description modes of ERP's relying on P3a and P3b relative peak amplitude (P300 with prominent P3a or P3b), topographical predominance (frontal or parietal P300) and duration of the late positive complex (brief or long-lasting P300). These data will improve the clinical use of P300. [less ▲]

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See detailEffects of iproflavone and its metabolites on human articular chondrocytes
Bassleer, Corinne; Franchimont, Paul; Henrotin, Yves ULg et al

in Osteoarthritis and Cartilage (1995), 4

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See detailAcquired Persistent Atypical Lentigines as a Failure of 5-Methoxypsoralen-Containing Sunscreens in the Photochemoprotection from Ultraviolet-Radiation-Induced Damage
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1995), 190(4), 338-340

Acquired persistent atypical lentigines are pigmentary lesions that are unusual both clinically and microscopically. They occur in young adults with photosensitive skin using 5-methoxypsoralen-containing ... [more ▼]

Acquired persistent atypical lentigines are pigmentary lesions that are unusual both clinically and microscopically. They occur in young adults with photosensitive skin using 5-methoxypsoralen-containing sunscreens during sunbathing. Their biologic behavior is benign, but there are grounds for concern regarding the carcinogenic risk in these patients. [less ▲]

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See detailThe flesinoxan 5-HT1A receptor challenge in major depression and suicidal behavior.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Pharmacopsychiatry (1995), 28 Suppl 2

The prevailing neurochemical theory about biological correlates of suicidal behavior focuses on the serotonergic system. In this study, we assessed the cortisol, ACTH, GH, prolactin and temperature ... [more ▼]

The prevailing neurochemical theory about biological correlates of suicidal behavior focuses on the serotonergic system. In this study, we assessed the cortisol, ACTH, GH, prolactin and temperature responses to flesinoxan, a5-HT1A agonist, in 30 DSM-III-R major depressed inpatients subgrouped into suicide attempters (n = 15) and nonattempters (n = 15). The patients were assessed after a drug-free period of at least 3 weeks. A subsample of 16 patients completed the Buss-Durkee Hostility Inventory as a measure of impulsive aggressive behavior. Mean delta cortisol responses to flesinoxan were significantly lower in the group of depressed patients with a history of suicide attempts than in the group without history of suicidal behavior: for the delta cortisol values 14.5 +/- 16.3 micrograms/l vs 101 +/- 94 micrograms/l (F = 8.9, df = 5.25, p = 0.006). There was also a very significant difference between suicide attempters and nonattempters for the temperature (delta T degrees) responses to flesinoxan: 0.20 +/- 0.24 degrees C vs. 0.60 +/- 0.24 degrees C (F = 18.1, df = 5.25, p = 0.0003). Hormonal and temperature responses to flesinoxan were not correlated with BDHI irritability or assault subscale scores. The results of the present study support the implication of the serotonergic system, particularly 5-HT1A receptors, in the control of self-directed aggressive behavior. Moreover, in depressed patients, serotonergic abnormalities do not appear to be related to aggressive behavior. [less ▲]

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