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See detailEtude de la variabilité sinusale par analyses temporelle et spectrale: intérêt clinique et perspectives
Bilge, A.; Pierard, Luc ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1995), 50(3), 120-5

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See detailDesign of electrical conductive composites : key role of the morphology on the electrical properties of carbon black filled polymer blends
Gubbels, Frédéric; Blacher, Silvia ULg; Vanlathem, E. et al

in Macromolecules (1995), 28(5), 1559-1566

Effect of carbon black (CB) on the morphology of filled polyethylene (PE)/polystyrene (PS) blends has been investigated by image analysis of optical micrographs (2-D analysis) and by the selective ... [more ▼]

Effect of carbon black (CB) on the morphology of filled polyethylene (PE)/polystyrene (PS) blends has been investigated by image analysis of optical micrographs (2-D analysis) and by the selective extraction of one phase of the binary blends (3-D analysis). The macroscopic electrical resistivity of the filled polyblends strongly depends on the selective localization of CB in one phase or at the interface and above all on the double percolation, i.e. percolation of the polymer phases and percolation of the CB particles. The selective localization of CB in the PE phase has remarkable effects on the polyblend phase morphology. The phase cocontinuity is indeed extended over a much larger composition range, and the phase morphology is stabilized toward post-thermal treatment at 200 degrees C. In the case of double percolation and selective localization of CB at the polyblend interface, electrical conductivity is observed at a CB content as low as 0.4 wt %. [less ▲]

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See detailPlasticization of biphasic ionomers by chemically identical, short, monofunctional oligomers
Plante, Michel; Bazuin, C Géraldine; Jérôme, Robert ULg

in Macromolecules (1995), 28(5), 1567-1574

Blends of carboxylated polystyrene ionomers containing 7 mol% of ionic units and carboxylate-terminated, monofunctional, monodisperse styrene oligomers of MW 800 were investigated by dynamic mechanical ... [more ▼]

Blends of carboxylated polystyrene ionomers containing 7 mol% of ionic units and carboxylate-terminated, monofunctional, monodisperse styrene oligomers of MW 800 were investigated by dynamic mechanical analysis and small angle X-ray scattering(SAXS). Both Cs and Ba carboxylate salts were studied,as well as blends of the Cs oligomer with homopolystyrene. The cluster phase is preferentially plasticized by the oligomers for both salts.; However, whereas the nonclustered phase of the Cs system is only a Little more plasticized than that of the Ba system, the cluster phase in the Cs system undergoes dramatic plasticization, the cluster transition disappearing at 5 wt % oligomer content. Simultaneously, the SAXS ''ionomer peak'' disappears. A peak reappears at 20 wt % oligomer content, suggesting the development of a new morphology, proposed to be micelles or ''inverted multiplets''. The difference between the two systems is attributed to the much stronger electrostatic interactions in the Ba system; this is analyzed in terms of elementary ion units. It is concluded that, whereas the nature of the nonpolar tail is relatively unimportant, the nature and strength of the electrostatic interactions involved can be of critical importance to the plasticization effects in blends of ionomers with short, monofunctional oligomers. [less ▲]

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See detailFungi die onychomycosis veroorzaken in Nederland
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Nederlands Tijdschrift voor Geneeskunde (1995), 139

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See detailOverproduction and properties of the mannuronate alginate lyase AlxMB
Malissard, Martine; Chavagnat, Frédéric; Duez, Colette ULg et al

in FEMS Microbiology Letters (1995), 126(2), 105-111

In previous studies (Malissard et al., FEMS Microbiol. Lett. (1993) 110, 101-106), the alginate lyase AlxM of the marine bacterium ATCC 433367 was produced in Escherichia coli TC4/pAL-A3 with a yield of ... [more ▼]

In previous studies (Malissard et al., FEMS Microbiol. Lett. (1993) 110, 101-106), the alginate lyase AlxM of the marine bacterium ATCC 433367 was produced in Escherichia coli TC4/pAL-A3 with a yield of 50 mu g per litre of culture. The polypeptide chain was cleaved between two cysteine residues, C169 and C183, themselves linked by a disulphide bridge. AlxM has now been overproduced in E. coli BL21(DE3)/pAL-Sur/pLysS. Under conditions in which formation of inclusion bodies can be avoided, the enzyme is synthesized as a catalytically active, water-soluble, unnicked polypeptide with a yield of 32 mg per litre of culture. It has been purified to protein homogeneity using a one-step procedure. The nicked ALxM(A) and unnicked ALxM(B) alginate lyases have identical alginate-degrading activities at high salt concentrations. [less ▲]

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See detailExcitation spectrum of FE2+ in a tetrahedral potential - Dynamic Jahn-Teller effect
Colignon, David ULg; Kartheuser, Eduard ULg; Rodriguez, Sergio et al

in Physical Review. B : Condensed Matter (1995)

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See detailThe importance of new chemical sources for the hot oxygen geocorona
Gérard, Jean-Claude ULg; Richards, P. G.; Shematovich, V. I. et al

in Geophysical Research Letters (1995), 22

Exothermic reactions involving metastable neutrals and ions were recently proposed as sources of hot oxygen atoms in addition to the classical O2(+) and NO(+) dissociative recombination. The Boltzmann ... [more ▼]

Exothermic reactions involving metastable neutrals and ions were recently proposed as sources of hot oxygen atoms in addition to the classical O2(+) and NO(+) dissociative recombination. The Boltzmann equations for thermal and nonthermal populations of O atoms are solved with Monte Carlo stochastic simulation method. It is shown that the calculated energy distribution functions of O atoms are significantly in nonequilibrium in the transition region between the thermosphere and the exosphere. It is found that the inclusion of additional sources leads to stronger disturbances of the energy distribution function and, as a consequence, increases the nonthermal fraction of hot O atoms. The variation of the vertical distribution of hot O between solar maximum and minimum conditions is also evaluated and shows good agreement with the available experimental evidence. [less ▲]

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See detailElectrical resistivity of AnT2Al3 (An = Np, Pu; T = Ni, Pd)
Seret, Alain ULg; Wastin, Franck; Waerenborgh, Joan-Carlos et al

in Physica B: Condensed Matter (1995), 206 & 207

Structural data and resistivity studies of NpNi2Al3, NpxU1−xPd2Al3 (x = 1, 0.5, 0.3, 0.1) and PuPd2Al3 are reported. The resistivity curves display Kondo features and clear anomalies at the magnetic ... [more ▼]

Structural data and resistivity studies of NpNi2Al3, NpxU1−xPd2Al3 (x = 1, 0.5, 0.3, 0.1) and PuPd2Al3 are reported. The resistivity curves display Kondo features and clear anomalies at the magnetic transition. Moreover, at least two kinds of magnetic structure exist in these compounds, one favouring the electrical conductivity and the other decreasing it. [less ▲]

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See detailMagnetic properties of Np2T2Sn compounds
Sanchez, Jean-Pierre; Colineau, E.; Jeandey, C. et al

in Physica B: Condensed Matter (1995), 206 & 207

The magnetic properties of the Np2T2Sn series investigated by 237Np Mössbauer spectroscopy are reported. Magnetic ordering is shown to occur for T --- Ni, Pd, Pt, whereas the Np ions do not carry a local ... [more ▼]

The magnetic properties of the Np2T2Sn series investigated by 237Np Mössbauer spectroscopy are reported. Magnetic ordering is shown to occur for T --- Ni, Pd, Pt, whereas the Np ions do not carry a local moment when T --- Co, Ru, Rh. Comparisons are made with the corresponding Np2T2In and U2T2Sn compounds. [less ▲]

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See detailLong-term photometry of variables at ESO. III. The third data catalogue (1990-1992).
Manfroid, Jean ULg; Sterken, C.; Cunow, B. et al

in Astronomy and Astrophysics. Supplement Series (1995), 109

In this paper we present the third catalogue of photometric data in the Stroemgren system obtained during the period October 1990-January 1992 in the framework of the Long-Term Photometry of Variables ... [more ▼]

In this paper we present the third catalogue of photometric data in the Stroemgren system obtained during the period October 1990-January 1992 in the framework of the Long-Term Photometry of Variables (LTPV) program at the European Southern Observatory. The catalogue is available in computer readable form at the Centre de Donnees de Strasbourg. [less ▲]

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See detailElectronic properties of U2Ni2Sn
Kindo, Koichi; Fukushima, T.; Kumada, T. et al

in Journal of Magnetism & Magnetic Materials (1995), 140-144(2), 1369-1370

We report on the bulk electronic properties of U2Ni2Sn, which crystallizes in the tetragonal U3Si2 structure. Pronounced anomalies in the temperature dependencies of magnetic susceptibility, specific heat ... [more ▼]

We report on the bulk electronic properties of U2Ni2Sn, which crystallizes in the tetragonal U3Si2 structure. Pronounced anomalies in the temperature dependencies of magnetic susceptibility, specific heat and electrical resistivity indicate magnetic ordering below TN = 26 K. An antiferromagnetic ground state is corroborated by the occurrence of three metamagnetic transitions at about 30, 39 and 51 T in the field dependence of the magnetization. The lack of any saturation tendency in the highest field applied (57 T) may suggest further transition(s) to occur in even higher fields. [less ▲]

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See detailMagnetism in U2T2X compounds
Havela, Ladislav; Sechovsky, Vladimir; Svoboda, P. et al

in Journal of Magnetism & Magnetic Materials (1995), 140-144(2), 1367-1368

Magnetic and other electronic properties are presented for the U2T2X compounds (T = late transition metal, X = Sn or In), that crystallize in the tetragonal U3Si2-type structure. They show the formation ... [more ▼]

Magnetic and other electronic properties are presented for the U2T2X compounds (T = late transition metal, X = Sn or In), that crystallize in the tetragonal U3Si2-type structure. They show the formation of 5f magnetic moments and antiferromagnetic ordering in compounds where weak 5f-d hybridization is expected. Near the onset of magnetic ordering strongly enhanced γ-values are found. Neutron-diffraction experiments on U2Pd2Sn and U2Pd2In point to a connection between the mutual coordination of U atoms and the type of magnetic anisotropy [less ▲]

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See detailMacrofagos e factor a de necrose tumoral na necrolise epidermica toxica
Paquet, Philippe ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Arquivos de Dermatologia (1995), 2

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular ... [more ▼]

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular inflamatorio varió dependiendo del estado de la enfermedad. La principal característica constante fue la importante implicación de la línea monocito-macrófago, incluyendo dendrocitos factor XIIIa+ HLA-DR+ y macrófagos CD68+ Mac 387+, antes y durante la necrosis epidérmica. El número de linfocitos CD4+ y CD8+ era comparativamente reducido. Ello se asociaba con un denso marcaje para el factor de necrosis tumoral alfa en la epidermis. CONCLUSIONES: Las células de estirpe monocito-macrófago superan en nùmero ampliamente a los linfocitos en las lesiones de la necrólisis epidérmica tóxica. El factor de necrosis tumoral alfa es problablemente una de las citocinas principales responsables de la necrosis. [less ▲]

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See detailAmpd, Essential for Both Beta-Lactamase Regulation and Cell Wall Recycling, Is a Novel Cytosolic N-Acetylmuramyl-L-Alanine Amidase
Jacobs, Christine ULg; Joris, Bernard ULg; Jamin, M. et al

in Molecular Microbiology (1995), 15(3), 553-9

In enterobacteria, the ampD gene encodes a cytosolic protein which acts as a negative regulator of beta-lactamase expression. It is shown here that the AmpD protein is a novel N-acetylmuramyl-L-alanine ... [more ▼]

In enterobacteria, the ampD gene encodes a cytosolic protein which acts as a negative regulator of beta-lactamase expression. It is shown here that the AmpD protein is a novel N-acetylmuramyl-L-alanine amidase (E.C.3.5.1.28) participating in the intracellular recycling of peptidoglycan fragments. Surprisingly, AmpD exhibits an exclusive specificity for substrates containing anhydro muramic acid. This anhydro bond is mainly found in the peptidoglycan degradation products formed by the periplasmic lytic transglycosylases and thus might behave as a 'recycling tag' allowing the enzyme to distinguish these fragments from the newly synthesized peptidoglycan precursors. The AmpD substrate (or substrates) which accumulates in the absence of the corresponding enzymatic activity acts as an intracellular positive effector for beta-lactamase expression and might represent an element of a communication network between the chromosome and the cell wall peptidoglycan. [less ▲]

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See detailThe role of agrometeorological data bases and software in agrometeorological training in developing countries.
Tychon, Bernard ULg; Tonnard, Victor

in FAO Agrometeorology series (1995), 13

The paper covers a Belgian agrometeorological training course intended for francophone students from developing countries who have completed a minimum of four years training in agrometeorology. Today ... [more ▼]

The paper covers a Belgian agrometeorological training course intended for francophone students from developing countries who have completed a minimum of four years training in agrometeorology. Today, many of our students are heads of agrometeorological departments and divisions. THey are interested in everything that could promote agrometeorological methods to preserve food security and the natural resources of their country. During the past few years, the students have been trained in using microcomputers and solving simple agro-meteorological problems as part of the course. The results obtained so far can now be evaluated, since the microcomputer training began a few years ago; some comments on the future development of this approach are presented. [less ▲]

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See detailPeroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives
Liégeois, Jean-François ULg; Rogister, F.; Delarge, J. et al

in Archiv der Pharmazie (1995), 328(2), 109-12

According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation ... [more ▼]

According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics. [less ▲]

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See detailLe cas clinique du mois. A propos d'un cas de sécrétion ectopique d'ACTH
Biessaux, Yves ULg; Paquot, Nicolas ULg; Scheen, A. J. et al

in Revue Médicale de Liège (1995), 50(2), 55-6

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See detailMagnetic kinetic growth-models
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg; Cloots, Rudi ULg

in Journal of Magnetism & Magnetic Materials (1995), 140(Part 3), 2185-2186

Magnetic kinetic growth models are kinetic growth model(s), like the Eden or the DLA models, but allow for the growth to have an extra degree of freedom (a 'spin') which can be coupled to an external ... [more ▼]

Magnetic kinetic growth models are kinetic growth model(s), like the Eden or the DLA models, but allow for the growth to have an extra degree of freedom (a 'spin') which can be coupled to an external field. Two-dimensional simulations show interesting morphologies and parameter dependences. [less ▲]

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See detailSpecificity and Sensitivity of Temporalis Es2 Measurements in the Diagnosis of Chronic Primary Headaches
Wang, W.; De Pasqua, Victor ULg; Gérard, P. et al

in Headache (1995), 35(2), 85-8

We have evaluated the specificity and sensitivity of temporalis ES2 measurements for the diagnosis of primary headaches. Ninety-four outpatients diagnosed according to IHS criteria were prospectively ... [more ▼]

We have evaluated the specificity and sensitivity of temporalis ES2 measurements for the diagnosis of primary headaches. Ninety-four outpatients diagnosed according to IHS criteria were prospectively included: 25 had chronic tension-type headache (code 2.2.), 15 episodic tension-type headache (code 2.1.), 20 migraine without aura (code 1.1.) and 34 chronic daily headaches with daily analgesics/ergotamine abuse (code 8.2.). In chronic tension-type, the sensitivity of the ES2 test was 84% at the 0.1 and the 0.5 Hz, but only 56% at the 2Hz stimulation rates. Its specificity was 100% at 0.1Hz, 90% at 0.5Hz and 95% at 2Hz compared to migraine; positive predictive values were at similar levels. Sensitivity of ES2 at 0.1 Hz was 67% in episodic tension-type headache, but its positive predictive value versus migraine was excellent. Comparing chronic tension-type headache and analgesic abusers, the specificity and positive predictive value of the ES2 test for diagnosing chronic tension-type headache were less satisfactory (60%) while the negative predictive values, however, remained good (83% at 0.1Hz). The results confirm that the temporalis ES2 test has a higher diagnostic sensitivity in chronic and episodic tension-type headache, but that it has a high negative predictive value for both types of tension-type headache compared to other primary headaches. For diagnostic purposes, the 0.1Hz stimulation rate seems optimal. The 2Hz stimulation rate is the least sensitive, although it may induce total disappearance of ES2 in up to 40% of patients. ES2 is of limited usefulness for separating chronic tension-type headache and chronic drug-abuse headache, possibly because the latter group comprises both tension-type headache and migraine patients. [less ▲]

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See detailSimulated growth and microstructure of DyBa2Cu3O7-X with and without Dy2BaCUO5 addition
Vandewalle, Nicolas ULg; Cloots, Rudi ULg; Ausloos, Marcel ULg

in Journal of Materials Research (1995), 10(2), 268-273

We present optical observations of magnetically melt-textured DyBa2Cu307-x with and without 20 wt. % excess of Dy2BaCu05. From these observations, we propose some kinetic mechanism of the growth of 123 ... [more ▼]

We present optical observations of magnetically melt-textured DyBa2Cu307-x with and without 20 wt. % excess of Dy2BaCu05. From these observations, we propose some kinetic mechanism of the growth of 123 compounds. Kinetic processes can simulated on computers. Two (very) simple models derived from the well-known Eden model are presented. They simulate the growth of the grain front. The simulated patterns agree with the observations. The microstructure of such materials cannot be explained by thermodynamic and chemical considerations alone, but explanations must include the kinetics of the growth front as well. From our observations, we conclude that the growth probability ratios g(110)/g(100)/g(001) are of the order of 10 and 50, respectively. [less ▲]

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See detailComment j'explore un patient hypertendu
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1995), 50(2), 91-92

Des examens complémentaires consitituent une étape importante de la prise en charge d'un patient hypertendu. Du bilan de base simple, peu coûteux et à appliquer à tous, aux examens paracliniques les plus ... [more ▼]

Des examens complémentaires consitituent une étape importante de la prise en charge d'un patient hypertendu. Du bilan de base simple, peu coûteux et à appliquer à tous, aux examens paracliniques les plus sophistiqués, la prescription nécessite cependant une personnalisation. II n'y a en effet pas une hypertension à explorer, mais des hypertendus, fort différents entre eux. Les examens à recommander vont cerner l'état actuel cardiaque, artériel et rénal ainsi que le profil de risque cardiovasculaire. Ils vont aussi rechercher une cause à l'élévation de pression si la clinique, l'anamnèse et quelques examens de laboratoire le suggèrent. [less ▲]

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See detailContribution of Mutant Analysis to the Understanding of Enzyme Catalysis: The Case of Class a Beta-Lactamases
Matagne, André ULg; Frère, Jean-Marie ULg

in Biochimica et Biophysica Acta (1995), 1246(2), 109-27

Class A beta-lactamases represent a family of well studied enzymes. They are responsible for many antibiotic resistance phenomena and thus for numerous failures in clinical chemotherapy. Despite the facts ... [more ▼]

Class A beta-lactamases represent a family of well studied enzymes. They are responsible for many antibiotic resistance phenomena and thus for numerous failures in clinical chemotherapy. Despite the facts that five structures are known at high resolution and that detailed analyses of enzymes modified by site-directed mutagenesis have been performed, their exact catalytic mechanism remains controversial. This review attempts to summarize and to discuss the many available data. [less ▲]

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See detailSimulation of Human B-Lymphocyte Proliferation by Agm-1470, a Potent Inhibitor of Angiogenesis
Antoine, Nadine ULg; Bours, Vincent ULg; Heinen, Ernst ULg et al

in Journal of the National Cancer Institute (1995), 87(2), 136-9

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See detailLes infections cutanées dues à l'herpès
Nikkels, Arjen ULg

in Actualités Médicales Belges (1995), 8(450),

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See detailSynthesis and Processing of Bovine Herpesvirus-1 Glycoprotein H
Baranowski, Eric; Dubuisson, Jean; van Drunen Little-van den Hurk, Sylvia et al

in Virology (1995), 206(1), 651-4

The translation product of the bovine herpesvirus-1 (BHV-1) gH gene was identified and characterized. Synthetic peptides were used to generate specific antisera and a glycoprotein of 108K was precipitated ... [more ▼]

The translation product of the bovine herpesvirus-1 (BHV-1) gH gene was identified and characterized. Synthetic peptides were used to generate specific antisera and a glycoprotein of 108K was precipitated by one of the antisera. Cross-immunoprecipitations with monoclonal antibodies to BHV-1 glycoprotein gp108 and the anti-gH peptide antiserum demonstrated that gp108 is the translation product of the gH open reading frame. Glycoprotein gH synthesis and intracellular processing was analyzed in infected Madin-Darby bovine kidney cells using anti-gp 108 monoclonal antibodies. Glycoprotein gH is expressed as a beta-gamma protein and could be detected by radioimmunoprecipitation as early as 2 hr postinfection. Cotranslational N-glycosylation of gH is essential for the recognition by monoclonal antibodies, suggesting that N-linked glycans are involved in protein folding or that they are targets for most of monoclonal antibodies used in this study. [less ▲]

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See detailIncreased Expression of Osteonectin and Osteopontin, Two Bone Matrix Proteins, in Human Breast Cancer
Bellahcene, Akeila ULg; Castronovo, Vincenzo ULg

in American Journal of Pathology (1995), 146(1), 95-100

Microcalcifications are a common phenomenon associated with breast cancer and are often the only mammographic sign of a malignant breast disease. Although microcalcifications are not restricted to breast ... [more ▼]

Microcalcifications are a common phenomenon associated with breast cancer and are often the only mammographic sign of a malignant breast disease. Although microcalcifications are not restricted to breast cancer and can be also associated with benign lesions, it is noteworthy that they are composed exclusively of hydroxyapatite in breast carcinoma. Hydroxyapatite is the bone-associated phosphocalcic crystal the deposition of which in bone tissue requires the coordinated expression of several molecules such as osteonectin (OSN) and osteopontin (OPN), synthesized by cells of the osteoblastic lineage. In this study, we evaluated the expression of these two bone matrix proteins, using an immunoperoxidase technique and specific antibodies, in 79 breast lesions including 28 benign and 51 cancerous specimens. We found that normal mammary tissue associated with the lesions examined expressed generally undetectable or lightly detectable (0 or 1+) amounts of OSN and OPN (92 and 81%, respectively). Benign breast lesions, including fibroadenoma and fibrocystic dysplasia, were generally weakly stained (0 or 1+) with both anti-OSN and anti-OPN antibodies (96.4 and 60.7%, respectively). Interestingly, the majority of both in situ and invasive breast carcinoma lesions showed a strong expression (2+ or 3+) for OSN or OPN (74.5 and 84.3%, respectively). High expression of these two bone matrix proteins was associated with frequent microcalcification deposition in the lesion. This study is the first extensive study of OSN and OPN expression in mammary cancers. Our data suggest that OSN and OPN could play a role in the formation of ectopic microcalcifications often associated with breast cancer. It is also tempting to speculate that the expression of these two glycoproteins by breast cancer cells play a role in the preferred bone homing of breast metastases. [less ▲]

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See detailKinetic Study of Interaction between Brl 42715, Beta-Lactamases, and D-Alanyl-D-Alanine Peptidases
Matagne, André ULg; Ledent, Philippe; Monnaie, Didier et al

in Antimicrobial Agents and Chemotherapy (1995), 39(1), 227-31

A detailed kinetic study of the interactions between BRL 42715, a beta-lactamase-inhibiting penem, and various beta-lactamases (EC 3.5.2.6) and D-alanyl-D-alanine peptidases (DD-peptidases, EC 3.4.16.4 ... [more ▼]

A detailed kinetic study of the interactions between BRL 42715, a beta-lactamase-inhibiting penem, and various beta-lactamases (EC 3.5.2.6) and D-alanyl-D-alanine peptidases (DD-peptidases, EC 3.4.16.4) is presented. The compound was a very efficient inactivator of all active-site serine beta-lactamases but was hydrolyzed by the class B, Zn(2+)-containing enzymes, with very different kcat values. Inactivation of the Streptomyces sp. strain R61 extracellular DD-peptidase was not observed, and the Actinomadura sp. strain R39 DD-peptidase exhibited a low level of sensitivity to the compound. [less ▲]

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See detailMagnetic diffusion-limited aggregation
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 51(1), 597-603

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See detailLe romancier en projet. Quand André Gide étudiait Georges Simenon
Denis, Benoît ULg

in Bulletin des amis d'André Gide (1995), XXVIII(105), 53-70

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See detailBasic Research and Policy Making for the Development of Vessel Traffic Management Information Systems
Marchal, Jean ULg

in Basic Research and Policy Making (1995)

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See detailInvestigation of the Relationship between Osteoporosis and the Collagenase Gene by Means of Polymorphism of the 5'upstream Region of This Gene
Thiry-Blaise, L. M.; Taquet, A. N.; Reginster, Jean-Yves ULg et al

in Calcified Tissue International (1995), 56

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we ... [more ▼]

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we investigated a possible relationship between the collagenase gene and osteoporosis. Analysis of an amplified genomic DNA fragment from -524 to +52 by denaturing gradient gel electrophoresis and sequencing allowed us to detect three dimorphic sites upstream of base -300, one of them leading to a BanI restriction site. None of the sites could be directly associated with osteoporosis. The allele frequencies of the three dimorphic sites were estimated. The interallelic ratios were high, thus providing new useful genetic markers for linkage analysis. When comparing these ratios in osteoporotic and nonosteoporotic subjects, no significant differences could be observed. [less ▲]

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See detailHypercholestérolémie modérée et coronaropathies: étude MAAS et étude 4S
Martinez, Christophe ULg; Legrand, Victor ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1995), 50(1), 35-40

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See detailA Prenatal Trisomy 21 Screening Program Using Alpha-Fetoprotein, Human Chorionic Gonadotropin, and Free Estriol Assays on Maternal Dried Blood
Verloes, Alain ULg; Schoos, Roland ULg; Herens, Christian ULg et al

in American Journal of Obstetrics and Gynecology (1995), 172(1, Pt 1), 167-74

OBJECTIVE: The feasibility of large-scale Down syndrome maternal screening with dried blood samples and nonradioactive methods was examined. STUDY DESIGN: A prospective observation study was performed on ... [more ▼]

OBJECTIVE: The feasibility of large-scale Down syndrome maternal screening with dried blood samples and nonradioactive methods was examined. STUDY DESIGN: A prospective observation study was performed on a nonselected population of 11,241 pregnant women sampled between January 1991 and September 1992, between 14 and 24 weeks' gestation (ultrasonographic scanning available for 91.6%), through a multicenter collaborative network. Enzyme-linked immunosorbent assays for alpha-fetoprotein, human chorionic gonadotropin, and free estriol were performed on dried blood samples. Risk determination was made with an in-house software implementing the multivariate gaussian log likelihood method. RESULTS: A total of 10,450 samples were eligible for the study. Mean age at term was 27.9 years. A total of 6.84% of the patients were > or = 35 years old with a prior risk of trisomy 21 > 1:350. The general positive rate of our sample was 8.15%. After calculation 31.7% with prior risk > 1:350 were still in the high-risk group; 6.36% of the low-risk group were found to be at high risk for Down syndrome. Fifteen trisomic pregnancies were observed, of which 11 had a calculated risk higher than the selected cutoff value (1:350). The overall detection rate was 73%, specificity was 92%, and positive predictive power was 1.2%. CONCLUSION: Our pilot study has shown performances within the range of conventional serum screening programs. Dried blood assays are a handy alternative to serum assays. Blot paper cards represent a simple method of sampling, well fitted for large population screening. Combined with nonradioactive methods, this method appears to be both low cost and effective. The current work apparently is the first large-scale Down screening program performed with dried blood. [less ▲]

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See detailTamoxifen and its active metabolite inhibit growth of estrogen receptor-negative MDA-MB-435 cells
Charlier, Corinne ULg; Chariot, Alain ULg; Antoine, Nadine ULg et al

in Biochemical Pharmacology (1995), 49

Tamoxifen (TAM), the non-steroidal anti-estrogen most widely administered to breast cancer patients, acts, at least in part, by competing with estrogen receptors (ER). However, the existence of an ... [more ▼]

Tamoxifen (TAM), the non-steroidal anti-estrogen most widely administered to breast cancer patients, acts, at least in part, by competing with estrogen receptors (ER). However, the existence of an alternative mechanism of action for this drug is supported by the clinical observations that: (a) 30% of patients with ER-negative cancer cells respond to TAM, and (b) 30% of patients with ER-positive cancer cells are not sensitive to this anti-estrogen. In this study, we observed that growth of the human ER-negative breast cancer cell line MDA-MB-435 was inhibited by TAM and 4-hydroxytamoxifen (4OH-TAM) in a concentration-dependent fashion. Both monoclonal enzymoimmunoassay and Dextran Charcoal Coated Scatchard radioimmunoassay analysis demonstrated that this MDA-MB-435 cell line does not express ER. The absence of ER in MDA-MB-435 cells was also demonstrated at the mRNA level by both northern blot hybridization and reverse transcription-polymerase chain reaction techniques. MDA-MB-435 cell proliferation was not affected by 17 beta-estradiol or by the pure anti-estrogen ICI 164384, further demonstrating that the observed effects of TAM and its active metabolite on the proliferation of MDA-MB-435 cells were due to an ER-independent mechanism, yet to be identified. MDA-MB-435 thus appears to be a promising original model for the study of the alternative ER-independent mechanisms of action of TAM. [less ▲]

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See detailComment je traite ... un patient avec une insuffisance cardiaque légère ou modérée?
Pierard, Luc ULg

in Revue Médicale de Liège (1995), 50(1), 5-6

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See detailA Frequency-Domain Processor for ScanSAR Images
Barbier, Christian ULg; Rosello-Guasch, Josep

in Preparing for the Future (1995), 5(4), 6-7

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See detailSatellite image maps of Warsaw in the scale 1 :25,000
Kaczynski, Rom; Donnay, Jean-Paul ULg; Muller, Fabrice

in EARSeL Advances in Remote Sensing (1995), 4(2), 100-103

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See detailÀ propos des graphies dans les Late Ramesside Letters
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

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See detailManagement of high turnover osteoporosis with calcitonin
Reginster, Jean-Yves ULg

in Osteoporosis Digest (1995), 3

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See detailLa mesure des echanges gazeux foliaires en ecophysiologie vegetale. Note technique sur la mise au point d'un systeme portable integre de mesure differentielle.
Laitat, E.; Boussard, H.; Aubinet, Marc ULg et al

in Bulletin des Recherches Agronomiques de Gembloux (1995), (3),

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See detailNF-kappaB transcription factor activation by hydrogen peroxide can be decreased by 2,3-dihydroxybenzoic acid and its ethylester derivative
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in Archives of Biochemistry & Biophysics (1995)

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See detailLes aliments à objectif nutritionnel particulier chez les carnivores domestiques: les nouvelles directives de la Communauté Européenne et leur application pratique dans le cadre du traitement de l'obésité
Diez, Marianne ULg; Leemans, M.; Houins, G. et al

in Annales de Médecine Vétérinaire (1995), 139

Specific - purpose food in compagnion animals: the new directories of the European Community and practical use in the treatment of obesity. Specific - purpose foods are often suggested by veterinarians in ... [more ▼]

Specific - purpose food in compagnion animals: the new directories of the European Community and practical use in the treatment of obesity. Specific - purpose foods are often suggested by veterinarians in the treatment of many diseases in compagnion animals. From 01/07/95, the directories of the European Community are applied. The present paper gives a reading of these directories and comments on the characteristics of these foods, the specific - purpose objectives and their use. Finaly, a dietetical approach of obesity is described using the different types of specific-purpose foods actually on the mark. [less ▲]

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See detailVaricella-zoster virus latency in the adult rat is a useful model for human latent infection
Sadzot-Delvaux, Catherine ULg; Debrus, Serge; Nikkels, Arjen ULg et al

in Neurology (1995), 45(12, suppl. 8), 18-20

A model of latent infection by varicella-zoster virus (VZV) was obtained in the adult rat. Inoculation of VZV-infected cells in the skin led to infection of the peripheral nervous system. Latency was ... [more ▼]

A model of latent infection by varicella-zoster virus (VZV) was obtained in the adult rat. Inoculation of VZV-infected cells in the skin led to infection of the peripheral nervous system. Latency was characterized by a long-lasting presence of the viral genome, of selected viral gene transcripts, and of at least one viral protein in the dorsal root ganglia. Reactivation has not been obtained in vivo, but has occurred ex vivo after repeated stresses. Many similarities with VZV latency in humans were found, making this model useful for vaccine and antiviral studies. [less ▲]

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See detailUtilisation de Biopesticides pour la protection des pommes en conservation
Jijakli, Haissam ULg; Lepoivre, Philippe ULg

in Le fruit belge (1995), (455), 83-88

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See detailLe traitement oncologique : polémique ou consensus ?
Coucke, Philippe ULg; MARTY

in Médecine et Hygiène (1995), 53(2076), 1371-1377

Les avis en oncologie sont souvent divergents. Ils illustrent un manque de «standard» thérapeutique bien établi. Cette revue a pour but de définir certaines de ces divergences fortement colorées par la ... [more ▼]

Les avis en oncologie sont souvent divergents. Ils illustrent un manque de «standard» thérapeutique bien établi. Cette revue a pour but de définir certaines de ces divergences fortement colorées par la spécialisation du médecin consulté. Ces divergences cesseront d'exister à condition de conduire des essais randomisés. Le praticien généraliste a un rôle prépondérant à jouer dans la motivation des malades afin qu'ils acceptent l'idée de ce genre d'étude. [less ▲]

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See detailSituation actuelle de la loutre, Lutra lutra, en Belgique et problématique de sa conservation
Libois, Roland ULg; Hallet, Catherine

in Cahiers d'Ethologie (1995), 15(2-3-4), 157-168

Widespread all over the country till the end of the last century, the otter has rapidly declined. In 1973 when hunting was definitely closed, the otter was already threatened and restricted to a few ... [more ▼]

Widespread all over the country till the end of the last century, the otter has rapidly declined. In 1973 when hunting was definitely closed, the otter was already threatened and restricted to a few localities. In 1889, the Belgian Ministry of agriculture decided to pay bounties for otters, a system which was cancelled only in 1963. Game statistics of the past century allow the annual otter bag to evaluated as roughly 25 % of the standing population. As it is the case in other European industrialised countries, freshwater habitat loss and water pollution lead to a considerable decrease of the river carrying capacity. Almost all the rivers flowing in the Northern part of Belgium are now lifeless or at least in a very bad condition. South of the river Meuse, some accidental pollutions are regularly reported (chloring in the river Ourthe in 1993; chloracetic acid in the Sûre in 1990...) and the level of organic pollution rises from year to year. Moreover, the tourism (angling, camp sites, kayak) nare more and more intensive leading to major disturbances, particularly during the summer months. Finally, the Ministery of equipment is developing a policy of big hydraulic works (dams, embankments, dredging...) along the river Ourthe, one of the last to be occupied by a few otters. [less ▲]

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See detailPhysiological measurements in horses after strenuous exercise in hot, humid conditions
Art, Tatiana ULg; Votion, Dominique ULg; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1995), 20

The purpose of this study was 1) to measure and compare some physiological parameters in horses during a standardised treadmill exercise performed either in temperate atmospheric conditions (TC) (ambient ... [more ▼]

The purpose of this study was 1) to measure and compare some physiological parameters in horses during a standardised treadmill exercise performed either in temperate atmospheric conditions (TC) (ambient temperature: 15 degrees C; relative humidity: 55%), or in hot and humid conditions (HHC) (ambient temperature: 30 degrees C; relative humidity: 75%) and 2) to follow the recovery of the same horses during 1 h after both tests. Five healthy fit Standardbred horses were investigated twice at 8 days interval, in TC and in HHC. Some measurements were made during a standardised treadmill exercise test (SET), others during a 1 h recovery period. The SET consisted of 8 min warm-up and 8 min exercise. During the SET, respiratory airflow and O2 and CO2 fraction in the respiratory gases were continuously recorded, using 2 ultrasonic pneumotachographs connected to a face mask and a mass spectrometer. Oxygen uptake (VO2), carbon dioxide output, respiratory quotient and expired minute volume (VE) were obtained on a breath-by-breath basis. The maximal values obtained during the highest intensity of the SET and the values obtained 2 min after the end of the test were used for the comparison between both tests. Heart rate (HR) and skin temperature were continuously recorded, using a heart rate recording system and a real time infrared thermographic unit, respectively. After both SETs in TC and HHC, the horses recovered in TC. Heart rate, respiratory frequency (f) and rectal temperature were regularly measured during 1 h after the test. Venous blood was sampled after the completion of the test for biochemical analysis, namely plasma electrolytes and enzymatic activities. Exercising in HHC induced a reduction of the aerobic metabolism to the total energy requirement, i.e. a 20% decrease of VO2 and 55% increase in lactate, as well as a decrease in VE. The increase in rectal and skin temperature, the dehydration and the weight loss were higher in HHC than in TC. During the recovery period the HR and f remained higher up to 30 min after the end of the SET in HHC while the rectal temperature remained higher up to 60 min after the end of this test. Therefore, despite the fact that our horses recovered in TC after exercising in HHC, there were significant differences between their physiological parameters measured during the recovery. This means that the recovery in air-conditioned unit would probably be an insufficient measure to ensure an adequate cooling of the horses and justify consequently the adaptations proposed by the Federation Equestre Internationale (FEI), i.e. the decrease of the distance of the run and the increase of the time devoted to the halt between phases [less ▲]

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See detailLa grammaire au secours de la datation des textes
Winand, Jean ULg

in Revue d'Egyptologie (1995), 46

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See detailQuelques alternatives à la régression classique dans le cas de la colinéarité
Palm, Rodolphe ULg; Iemma, A. F.

in Revue de Statistique Appliquée (1995), XLIII(2), 5-33

In this note, we briefly describe some biased regresion methods : principal component regression, latent root regression analysis, partial least square regression, ridge regression and use of James-Stein ... [more ▼]

In this note, we briefly describe some biased regresion methods : principal component regression, latent root regression analysis, partial least square regression, ridge regression and use of James-Stein's estimators. All these methods are illustrated by an example. [less ▲]

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See detailEtude épidémiologique de la toxoplasmose chez les femmes enceintes à Amiens (Picardie): nécessité d'une enquête nationale
Carme, Bernard; Lenne, Evelyne; Tirard, Véronique et al

in Journal de Pédiatrie et de Puériculture (1995), 8(1), 761-763

Il s'agit d'une enquête réalisée à Amiens du 1er mars 1993 au 28 février 1994 chez les femmes venant d'accoucher pour évaluer leur niveau d'immunité vis à vis de la toxoplasmose et leur connaissances des ... [more ▼]

Il s'agit d'une enquête réalisée à Amiens du 1er mars 1993 au 28 février 1994 chez les femmes venant d'accoucher pour évaluer leur niveau d'immunité vis à vis de la toxoplasmose et leur connaissances des mesures préventives. L'analyse des données s'est faite grâce au locigiel Epidemio sur un total de 987 femmes. La séroprévalence est de 58% et l'analyse montre que c'est la consommation de viande peu ou pas cuite et la présence d'un chat dans l'entourage qui sont les 2 facteurs de risque majeurs. La quasi totalité des femmes a pu citer au moins 2 moyens de prévention efficaces et les reccommandations sont largement suivies. En conclusion, les résultats sont rassurants. Cependant, une enquête nationale serait nécessaire pour permettre une évaluation sur le plan national. [less ▲]

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See detailPotentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks
Schoenen, Jean ULg; Wang, W.; Albert, A. et al

in European Journal of Neurology (1995), 2

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See detailInfection respiratoire équine à Bordetella bronchiseptica
Vandevenne, S.; Caudron, I.; Serteyn, Didier ULg et al

in Annales de Médecine Vétérinaire (1995), 139

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See detailISOLATION OF SUCROSE SYNTHASE FROM RICE (ORYZA-SATIVA) GRAINS IN PILOT-SCALE FOR APPLICATION IN CARBOHYDRATE SYNTHESIS
ELLING, Lothar; GULDENBERG, Birgit; GROTHUS, Marita et al

in Biotechnology & Applied Biochemistry (1995), 21(Part 1), 29-37

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the ... [more ▼]

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the 9 kg scale of rice (Oryza sativa) grains was achieved in five steps with 11.3% yield and 192-fold purification. The final sucrose synthase preparation was free of nucleotide di- and monophosphatases, but did contain 0.05% of both invertase and UDP-glucose-hydrolysing activity. It can be efficiently utilized for the synthesis of activated sugars. Its application for the synthesis of saccharides is possible taking into account that 15% UDP-glucose is hydrolysed within 15 h incubation time [less ▲]

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See detailRapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression
Wera, Stefaan; Belayew, Alexandra; Martial, Joseph ULg

in FEBS Letters (1995), 358(2), 158-60

In this work we demonstrate that transcription of the human prolactin gene is inhibited by the immunosuppressants FK506 (IC50 = 25 nM), cyclosporin A (IC50 = 190 nM) and rapamycin (IC50 = 25 nM). Whereas ... [more ▼]

In this work we demonstrate that transcription of the human prolactin gene is inhibited by the immunosuppressants FK506 (IC50 = 25 nM), cyclosporin A (IC50 = 190 nM) and rapamycin (IC50 = 25 nM). Whereas the effect of FK506 and cyclosporin A is specific for prolactin gene transcription, rapamycin has a more general effect on transcription and/or translation in pituitary cells. In view of recent work demonstrating the immunoactivating role of prolactin, these results suggest that inhibition of prolactin gene expression in the pituitary may contribute to the mechanism of action of immunosuppressants. [less ▲]

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See detailLong run behaviour of Pacific-Basin stock prices
Corhay, Albert ULg; Tourani-Rad, Alireza; Urbain, Jean-Pierre ULg

in Applied Financial Economics (1995), 5(1), 11-18

In this paper, we investigate the long run relationship among five major Pacific-Basin stock markets. We focus on the common long run behaviour of their stock price indices over a sample period of 20 ... [more ▼]

In this paper, we investigate the long run relationship among five major Pacific-Basin stock markets. We focus on the common long run behaviour of their stock price indices over a sample period of 20 years. Using cointegration theory, we find that while there exists a rather integrated Pacific Basin financial area, the regional aspects (Asian versus Pacific) play important roles. [less ▲]

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See detailEntre sémantique et syntaxe. Pour une classification des lexèmes verbaux en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

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See detailIntérêt de la cyclosporine et du méthotrexate dans le traitement de l'asthme.
weber, T.; Skaventos, I.; Kayembe, J. et al

in Médecine et Hygiène (1995), 53

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See detailSuperovulation in cows with FSH preparation containing different amounts of LH
Smorag, Z.; Beckers, Jean-François ULg; Bychawski, S. et al

in Roczniki Naukowe Zootechniki (1995), 22(2), 103-108

One of the main factors influencing the effectiveness of superovulation is the quality of gonadotropin used.Especially the proportion of FSH to Lh can play an important role.In the experiment ... [more ▼]

One of the main factors influencing the effectiveness of superovulation is the quality of gonadotropin used.Especially the proportion of FSH to Lh can play an important role.In the experiment superovulatory response of cows treated with FSH containing different amounts of LH was evaluated.Observations were carried out on 120 Polish Black-and-White Lowland cows aged from 5 to 8 years.On day 9, 10 and 11 after oestrus, 40 mg of FSH containing 10,20 or 40% of LH was injected in 8 decreasing doses at 12 h intervals.In the control group 3000 IU PMSG per cow was administrated.Forty-eight hours after the initial FSH or PMSG injection, 3 ml PGF 2-alpha analog was injected to donors to induce oestrus.An average of 5.6, 5.3, 3.9 and 1.7 transferable embryos was recovered after treatment of the cows with FSH +20% LH, FSH +40% LH, FSH +10% LH and PSMG, respectively. [less ▲]

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See detailGlucose inhibits human placental GH secretion, in vitro
Patel, N.; Alsat, E.; Igout, Ahmed ULg et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(5), 1743-6

Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation ... [more ▼]

Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation remains unknown. In this study the effect of glucose on PGH secretion by human term placenta was tested, in vitro, by means of two different experimental models: organ culture of villous tissue and primary culture of isolated cytotrophoblasts. PGH was assayed in the culture medium by an immunoradiometric assay using a specific PGH monoclonal antibody. The presence of glucose (25 mmol/L) in the culture medium significantly inhibited (p < 0.001) the secretion of PGH by either placental villous explants or by cultured trophoblast cells. This inhibitory effect of glucose on PGH secretion was dose-dependent. More than 50% inhibition being observed with 5.5 mmol/L. In the same conditions, the daily production of hPL and hCG, were unmodified. Furthermore, the glucose-induced inhibition of PGH secretion was more effective when cultured trophoblast cells are differentiated into syncytiotrophoblast. This study demonstrates, for the first time, that among the gestational polypeptide hormones secreted by the human placenta, only PGH secretion is modulated by glucose, suggesting a key metabolic role for this hormone during pregnancy. [less ▲]

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See detailPathophysiological response of bovine pulmonary function to gastric distension
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Journal of Comparative Pathology (1995), 112

The purpose was to determine whether gastric overdistension leads to lifethreatening perturbations of pulmonary gas exchange in healthy calves. Six animals were studied with normal (0 kPa) and increased ... [more ▼]

The purpose was to determine whether gastric overdistension leads to lifethreatening perturbations of pulmonary gas exchange in healthy calves. Six animals were studied with normal (0 kPa) and increased (1, 2, 3, 4 and 5 kPa) intragastric pressure (IGP). Changes in pleural pressures and peak expiratory flow paralleled those of IGP. Inspiratory pressure-time index remained stable throughout the insufflation process. Pulmonary function values were characterized by abrupt changes with increasing IGP. Tidal volume declined as IGP increased and, along with inspiratory flow, decreased abruptly with the highest pressure (5 kPa). Respiratory rate progressively increased up to an IGP of 4 kPa, then decreased by 30%, due to breath-holding at the end of inspiration. Minute volume increased with IGP up to 4 kPa, but dramatically declined at 5 kPa. Total pulmonary resistance remained stable throughout the insufflation process, whereas lung dynamic compliance fell abruptly to one-half of its baseline value at IGPs of 1 kPa and above. Arterial oxygen tension was maintained at an IGP of 1 kPa, slightly diminished at 2–3 kPa, and markedly decreased at 4–5 kPa. Hypercapnia and respiratory acidosis developed progressively with increasing IGP. Changes in arterial gases were probably due to a combination of (1) alveolar hypoventilation, caused by altered tidal to dead space volume ratio, inadequate central nervous system “drive”, altered effectiveness of inspiratory muscle action, or end-inspiratory breath-holding, and (2) ventilation to perfusion mismatch, caused by perfusion of collapsed lung units. In the range of IGPs used, standardized arterial pH did not decline below the control value, which suggests that perfusion of peripheral tissues remained sufficient, and that respiratory failure rather than cardiovascular failure may be the principal physiopathological effect of increased gastric pressure [less ▲]

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See detailAbsence probable de la translocation Robertsonienne 1/29 en race bovine Blanc Bleu Belge
Nicolas, N.; Hidas, A.; Renaville, Robert ULg et al

in Genetics, Selection, Evolution (1995), 27(4), 377-380

The 1/29 translocation, a structural chromosomal abnormality, is often associated with infertility. For this reason, we wished to know its frequency in the Belgian Blue breed. In this study, none of the ... [more ▼]

The 1/29 translocation, a structural chromosomal abnormality, is often associated with infertility. For this reason, we wished to know its frequency in the Belgian Blue breed. In this study, none of the 138 Belgian Blue bulls karyotyped carried the 1/29 translocation. We calculated that the 1/29 translocation frequency in the Belgian Blue breed must be lower than 0.69% at the 5% level. This result can be explained by the origins of the breed. The Belgian Blue breed is descended from focal dairy breeds and from the Shorthorn breed, which can all be considered to be free of the 1/29 translocation. [less ▲]

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See detailClinical, electrocardiographic and echocardiographic improvements after L-carnitine supplementation in cardiomyopathic dog.
Mc Entee, Kathleen ULg; Clercx, Cécile ULg; Snaps, Frédéric ULg et al

in Canine Practice (1995), 20(2), 12-15

In dogs suffering from dilated cardiomyopathy, myocardial concentrations of L-carnitine are sometimes very low. A Labrador suffering from dilated cardiomyopathy was treated with L-carnitine. The dog ... [more ▼]

In dogs suffering from dilated cardiomyopathy, myocardial concentrations of L-carnitine are sometimes very low. A Labrador suffering from dilated cardiomyopathy was treated with L-carnitine. The dog showed a clear and rapid clinical improvement as well as an improvement of electrocardiographic and echocardiographic indices of cardiac function. Screening by myocardial biopsy in dogs affected by dilated cardiomyopathy and in susceptible breeds is recommended. The dog had been maintained on a strict vegetarian diet. [less ▲]

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See detailR&D, technological progress and efficiency change in industrial activities
Perelman, Sergio ULg

in Review of Income and Wealth (1995), (41), 349-366

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic ... [more ▼]

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic frontiers and non-parametric production frontiers (DEA). The TFP is decomposed into two components, technological progress and efficiency change, that can also be interpreted as the results of the innovation and catching-up process, respectively. Finally their relationship is tested with a set of potential explanatory variables that includes R&D expenditures, international competition, and structural characteristics. It appears that the distinction between technological and efficiency performances does matter and must be taken into account in the design of industrial policy. [less ▲]

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See detailPathophysiological response of bovine diaphragm function to gastric distension
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Journal of Applied Physiology (1995), 78

Because of the anatomic association of an exceptionally bulky stomach with a striking compartmentation of the chest wall, leading to the most cranial insertion of the diaphragm among mammals, gastric ... [more ▼]

Because of the anatomic association of an exceptionally bulky stomach with a striking compartmentation of the chest wall, leading to the most cranial insertion of the diaphragm among mammals, gastric overdistension in the bovine species offers a unique pathophysiological condition for the diaphragm. The purpose of the present study was to determine whether increased intragastric pressure (Pga) (1, 2, 3, 4, and 5 kPa) leads to perturbations of respiratory and diaphragm function in calves. Changes in diaphragmatic strength and inspiratory action followed a biphasic pattern: 1) transdiaphragmatic pressure (Pdi) in response to constant bilateral maximal phrenic nerve stimulation at 30 Hz increased with moderate gastric distension and then fell abruptly as Pga continued to rise and 2) the magnitude of the ratio of the fall in pleural pressure to total Pdi was maintained up to a Pga amounting to 2 kPa but declined at higher pressures. We conclude that gastric distension in the bovine species provokes physiologically significant alterations of the diaphragm excitation-to-pressure generation coupling as well as of its capacity to convert Pdi into useful inspiratory pleural pressure. We suggest that these perturbations resulted from the combination of 1) altered tension-generating capacity due to compromised perfusion, 2) altered diaphragm geometry capable of altering tension-to-pressure generation coupling, and 3) modified coupling of the diaphragm with the chest wall that reduced its ability to drive inspiration [less ▲]

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See detailMolecular description of the interactions of aminoglycoside antibiotics with negatively-charged phospholipids. Theoretical molecular modelling and experimental results.
Mingeot-Leclercq, M. P.; Schanck, A.; Van Bambeke, F. et al

in Pharmacology (1995), 14

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See detailMethode d’évaluation radiologique du parage et de l’extremité digitée du cheval dans un plan frontal
Serteyn, Didier ULg; Miesen, M.; Caudron, I. et al

in Journal Européen de Maréchalerie (1995), 7

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See detailConformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Research Communications In Molecular Pathology and Pharmacology (1995), 90(1), 153-64

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation ... [more ▼]

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation of the molecular hydrophobicity potential. The calcium complexes formed with KAD-1229, A-4166, repaglinide or its enantiomer, displayed favourable attributes to act as ionophores. Such was not the case for the poorly efficient insulinotropic agent meglitinide and the biologically inactive enantiomer of A-4166. The configuration of the calcium complex formed with S 3075 also failed to display the features required for a high ionophoretic capacity. [less ▲]

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See detailPolitics in the lifeboat. Immigrants and the American Democratic Order de J.C. Harles
Martiniello, Marco ULg

in International Migration Review (1995), 28(108), 900-901

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See detailLes routes de la foi en pays mosan (IVe-XVe siècles). Sources, méthode et problématique
George, Philippe ULg

in Feuillets de la Cathédrale de Liège (1995)

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See detailBioremediation of diesel-polluted soils.
Jacques, Ph; Bossrez, S.; Mergeay, M. et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103(B46),

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See detailLe rôle du foie dans l'homéostasie glucidique: une relecture des travaux de Claude Bernard
Lefebvre, P.; PAQUOT, Nicolas ULg; SCHEEN, André ULg

in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (1995)

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See detail"L'effervescence a gagné la cité". A propos d'un monument et d'une fontaine sur la place Saint-Lambert
George, Philippe ULg

in Chronique de la Société Royale Le Vieux-Liège (1995)

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See detailNew dibenzazepine derivatives with disinhibitory and/or antidepressant potential: neurochemical and behavioural study in the open-field and forced swimming tests.
Bruhwyler, J.; Liégeois, Jean-François ULg; Lejeune, C. et al

in Behavioural pharmacology (1995), 6(8), 830-838

Original bioisosteric analogues of clozapine were evaluated for potential disinhibitory and/or antidepressant effects using the open-field test in the rat and Porsolt's forced swimming test in the mouse ... [more ▼]

Original bioisosteric analogues of clozapine were evaluated for potential disinhibitory and/or antidepressant effects using the open-field test in the rat and Porsolt's forced swimming test in the mouse. Attempts to relate the behavioural results to the binding affinities for dopamine (D1, D2), serotonin (5-HT(2)) and muscarinic (M) receptors were also undertaken. In the open-field test, two main profiles were observed. The first profile corresponded to disinhibitory molecules resembling diazepam and ritanserin. The second profile corresponded to antipsychotic compounds resembling either typical (haloperidol, clothiapine) or atypical (clozapine) neuroleptics. The results obtained in the forced swimming test confirmed the neuroleptic-like activity of the second group of compounds, while two compounds of the first group (JL 3 and JL 26) showed an antidepressant-like activity, JL 3 being as active as imipramine. While it was not possible to relate the first profile to any binding interaction, a relation could be established among the second group of compounds between the typical or atypical antipsychotic behavioural profile and the 5-HT(2)/D2 ratio. [less ▲]

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See detailA Simple Model for the Fire Resistance of Axially-Loaded Members According to Eurocode 3
Franssen, Jean-Marc ULg; Schleich, Jean-Baptiste; Cajot, Louis-Guy

in Journal of Constructional Steel Research (1995), 35

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental ... [more ▼]

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental test results. This model has been subsequently included in Eurocode 3. [less ▲]

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See detailLa naissance des cités au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailLa transmission du chant chez le Pinson des arbres (Fringilla c. coelebs) : phase sensible et rôle des tuteurs chez les oiseaux captifs.
Metzmacher, Maxime ULg

in Alauda (1995), 63

Learning plays a key role (Thorpe 1954) in the way song pattern develops in the Chaffinch. In experiments conducted and related here by Léon Hakin, the rearing of young Chaffinches in the presence of ... [more ▼]

Learning plays a key role (Thorpe 1954) in the way song pattern develops in the Chaffinch. In experiments conducted and related here by Léon Hakin, the rearing of young Chaffinches in the presence of adults of the same species suggests that : - learning of song can be relatively precise ; the young imitate the song(s) heard from its « teachers » during this period. This confirms experiments done by other researchers under different conditions (Slater & Ince 1982, Thielcke & Krome 1989). Some differences may however occur, particurlarly the form of the reproduced syllabes and their rythm of emision. - during its second calendar year, a bird placed in a new sound atmosphere can acquire new phrases and, apparently, forget its previous repertory. - certain young birds build up their repertory by coping phrases from different individuals and copy many of them for fixing the tempo of their song. The aim of the discussion is to find the characteristics of the sensitive period, the importance of social interactions on the process of song learning, the building of a repertory and the formation of dialects. In the last two phenomena, a process of dynamic and selective restructuration appears to be implied. [less ▲]

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See detailLa gestion agro-économique dans la Cordillère Nord-Andine
Cotler, Helena; Bock, Laurent ULg; Mathieu, Léon

in Cahiers de la Recherche-Développement (Les) (1995), (42), 28-45

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See detailBeyond Borders. West European Migration Policy towards the 21st Century de S. Collinson
Martiniello, Marco ULg

in Ethnic and Racial Studies (1995), 18(2), 421-422

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See detailReaction Window in the single-electron capture by Ammonia Dications.
Leyh, Bernard ULg; Hoxha, Antuan

in Chemical Physics (1995), 192

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC ... [more ▼]

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC cross-section goes through a maximum within a reaction window centered at an exothermicity of approximately 4.5 eV. This corresponds to a target-projectile distance for the charge transfer of about 3.2 Angstöm. The average internal energy of NH3+-ions resulting from SEC has been obtained both via translational energy gain measurements and via an analysis of the daughter ion spectra. The agreement between both methods is satisfactory and shows that the lower the ionisation energy of the target, the more probable the excitation of NH3+ to the A2E state. With benzene (ionization energy=9.25 eV) as the target gas, however, the excess energy is converted partly to internal energy of C6H6+, leading most probably to the D2B2u, E2B1u and F2A1g states of C6H6+. A model based on the Landau-Zener non-adiabatic formalism, including one entrance channel (NH32++G) and two exit channels (NH3+ X2A"2+G+ and NH3+ A2E+G+) accounts qualitatively for the observed results in the case of exothermic single-electron capture. This model is not appropriate for slightly exothermic and endothermic charge transfer, i.e., in the present case, for the Ne and He target gases. [less ▲]

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See detailCatecholaminergic function and P300 amplitude in major depressive disorder (P300 and catecholamines).
Hansenne, Michel ULg; Pitchot, William ULg; Gonzalez Moreno, Antonio et al

in Electroencephalography and Clinical Neurophysiology (1995), 96(2), 194-6

The neurobiology of P300 is still a subject of controversy. P300 amplitude appears to be modulated by multiple neurotransmitter systems, especially dopaminergic, noradrenergic as well as cholinergic and ... [more ▼]

The neurobiology of P300 is still a subject of controversy. P300 amplitude appears to be modulated by multiple neurotransmitter systems, especially dopaminergic, noradrenergic as well as cholinergic and GABAergic. In this study, we investigated the relationship between P300 amplitude and catecholaminergic neurotransmission as assessed by the growth hormone (GH) response to clonidine and apomorphine challenges in 20 major depressive patients. Results showed a correlation of P300 amplitude with the apomorphine test (r = 0.54; P = 0.01), but not with the clonidine test (r = 0.22; NS). This study supports a role for dopamine in the neurobiological modulation of P300 amplitude. [less ▲]

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See detailSpatio-temporal aquatic vegetation patterns in former channels in relation to their isolation from the river Rhine (Eastern France)
Klein, J. P.; Robach, F.; Vanderpoorten, Alain ULg et al

in Acta Botanica Gallica : Bulletin de la Société Botanique de France (1995), 142

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See detailComment explorer la sensibilite a l'insuline chez l'homme?
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in Annales d'Endocrinologie (1995), 56(5), 523-30

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose ... [more ▼]

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose clamp is the reference method, well validated and easy to interpret, which allows various extensions to the basic experimental procedure in order to obtain more valuable information on the specific effects of insulin on the various aspects of glucose metabolism. However, it is time-consuming and labour-intensive. In contrast, the intravenous glucose tolerance test is easier to perform, but its interpretation is much more difficult and requires a modeling approach called the "minimal model". If the intravenous glucose tolerance test probably represents a good screening test, mainly on a population basis, the glucose clamp still remains the gold standard method to study insulin sensitivity in man. [less ▲]

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See detailLes cellules dendritiques folliculaires: phenotype, origine et fonctions.
Heinen, Ernst ULg

in Pathologie Biologie (1995), 43(10), 848-57

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic ... [more ▼]

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic cells presenting antigens to T cells. They are long-lived and derived from local mesenchymal cells. Their complex cytoplasmic extensions, covered with dendrites, are intermingled in a network which surrounds germinal B and T cells. On their surface, receptors fix immune complexes without endocytosis and adhesion molecules ensure close contacts to the lymphoid cells. FDC influence the migration, activation, proliferation, survival and differentiation of B cells into memory cells and probably act also on the germinal center T cells. [less ▲]

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See detailImproving the action of insulin.
Lefebvre, Pierre ULg; Scheen, André ULg

in Clinical & Investigative Medicine = Médecine Clinique et Experimentale (1995), 18(4), 340-7

Improving the action of insulin is a relatively new concept in diabetes management. Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by ... [more ▼]

Improving the action of insulin is a relatively new concept in diabetes management. Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by correcting a subclinical magnesium deficiency. Pharmacological means of improving insulin action include metformin, antiobesity serotoninergic agents and, possibly, benfluorex. New compounds aiming at improving the action of insulin are in development and include thiazolidinedione derivatives (known as "insulin sensitizers"), inhibitors of adipose tissue lipolysis (e.g. acipimox), and inhibitors of free fatty acid oxidation (e.g. etomoxir). Avoidance of drugs that reduce insulin sensitivity, such as beta blockers and thiazide diuretics, is recommended. Finally, cigarette smoking is associated with resistance to insulin but it remains to be demonstrated that cessation of cigarette smoking does in fact increase sensitivity to insulin. [less ▲]

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See detailUtilisation des matières grasses chez les bovins à l'engraissement
Clinquart, Antoine ULg; Micol, Didier; Brundseaux, Christophe et al

in Productions Animales (1995), 8

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See detailANISOTROPY OF THE MIXED-STATE IN TEXTURED PB-FREE BI-2223 SUPERCONDUCTOR - ELECTRICAL-RESISTIVITY, SEEBECK AND NERNST EFFECTS
PEKALA, M.; Bougrine, Hassan ULg; LADA, T. et al

in Superconductor Science & Technology (1995), 8(9), 726-739

Anisotropy of transport entropy and of Hall angle are reported for the first time through various electrical and thermal transport properties, such as the electric resistivity and the Seebeck and the ... [more ▼]

Anisotropy of transport entropy and of Hall angle are reported for the first time through various electrical and thermal transport properties, such as the electric resistivity and the Seebeck and the Nernst effects (in the presence of a magnetic field ranging between 0 and 4 T), measured for a Pb-free textured Bi-2223 system. The field and temperature influence in the mixed state region is reported only for the H parallel to a and H parallel to c cases and the temperature gradient applied along the b direction. A much stronger influence of magnetic field along the c than the a axis is demonstrated. The relative evolution of the so-called 'excess transport effects' is discussed. We show the laws relating the respective losses to the applied magnetic field. This leads us to the understanding that anisotropic vortex kinetics exist in these systems. We consequently propose two original routes of theoretical investigations to be considered for the calculation of Nernst and TEP effects in a field, in particular to consider a vortex-carrier drag phenomenon. [less ▲]

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See detailSecondary structure of monoamine oxidase by FTIR spectroscopy.
Wouters, J.; Ramsay, R.; Goormaghtigh, E. et al

in Biochemical and Biophysical Research Communications (1995), 208(2), 773-8

The secondary structure of human monoamine oxidase A and bovine monoamine oxidase B has been investigated by Fourier Transform Attenuated Total Reflection Spectroscopy (FTIR ATR). The experimental results ... [more ▼]

The secondary structure of human monoamine oxidase A and bovine monoamine oxidase B has been investigated by Fourier Transform Attenuated Total Reflection Spectroscopy (FTIR ATR). The experimental results are compared for both isoenzymes and the data are incorporated in a statistical attribution of secondary structure of the enzyme describing the distinct folding and molecular specificity of the two types of monoamine oxidase. [less ▲]

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See detailInteractions between IL-1bêta, IL-6, IL-8 and LIF produced by human chondrocytes
Henrotin; Franchimont, P; Reginster, Jean-Yves ULg

in The Official EULAR Journal for Education and Information (1995), 24

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See detailTransgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
Plumier, Jean-Christophe ULg; Ross, B.; Currie, R. W. et al

in Journal of Clinical Investigation (1995), 95(4), 1854-60

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock ... [more ▼]

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock proteins, the amount of the inducible heat shock protein 70 (HSP70) and the level of myocardial protection. The inducible HSP70 has also been shown to be protective in transfected myogenic cells. Here we examined the role of human inducible HSP70 in transgenic mouse hearts. Overexpression of the human HSP70 does not appear to affect normal protein synthesis or the stress response in transgenic mice compared with nontransgenic mice. After 30 min of ischemia, upon reperfusion, transgenic hearts versus nontransgenic hearts showed significantly improved recovery of contractile force (0.35 +/- 0.08 versus 0.16 +/- 0.05 g, respectively, P < 0.05), rate of contraction, and rate of relaxation. Creatine kinase, an indicator of cellular injury, was released at a high level (67.7 +/- 23.0 U/ml) upon reperfusion from nontransgenic hearts, but not transgenic hearts (1.6 +/- 0.8 U/ml). We conclude that high level constitutive expression of the human inducible HSP70 plays a direct role in the protection of the myocardium from ischemia and reperfusion injury. [less ▲]

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See detailGrowth hormone response to clonidine in nondepressed patients with a history of suicide attempts.
Pitchot, William ULg; Hansenne, Michel ULg; Moreno, A. G. et al

in Biological Psychiatry (1995), 38(3), 201-3

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See detailCytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime.
Mathy, Marianne ULg; Deby, Ginette ULg; Deby, C. et al

in Mediators of Inflammation (1995), 4(6), 437-43

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system ... [more ▼]

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system, myeloperoxidase catalyses the conversion of H(2)O(2) and CI(-) to the cytotoxic agent HOCl. Stimulated neutrophils can release MPO into the extracellular environment and then may cause tissue injury through direct endothelial cells lysis. We showed that human umbilical vein endothelial cells (HUVEC) were capable of taking up active MPO. In presence of H(2)O(2) (10(-4) M), this uptake was accompanied by cell lysis. The cytolysis was estimated by the release of (51)Cr from HUVEC and expressed as an index of cytotoxicity (IC). Dose dependent protection was obtained for CAZ concentrations ranging from 10(-5) to 10(-3) M;this can be attributed to inactivation of HOCl by the drug. This protection is comparable to that obtained with methionine and histidine, both of which are known to neutralize HOCl. This protection by CAZ could also be attributed to inactivation of H(2)O(2), but when cytolysis was achieved with H(2)O(2) or O(2) (-) generating enzymatic systems, no protection by CAZ was observed. Moreover, the peroxidation activity of MPO (action on H(2)O(2)) was not affected by CAZ, while CAZ prevented the chlorination activity of MPO (chlorination of monochlorodimedon). So, we concluded that CAZ acts via HOCl inactivation. These antioxidant properties of CAZ may be clinically useful in pathological situations where excessive activation of neutrophils occurs, such as in sepsis. [less ▲]

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See detailPersonal name anomia: A single case study
Fery, P.; Vincent, Eric ULg; Brédart, Serge ULg

in Cortex (1995), 31

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See detailHyperfine structure of infrared vanadium lines
Palmeri, P.; Biémont, Emile ULg; Aboussaïd, A. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

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See detailSerum erythropoietin during autologous bone marrow transplantation: relationship to measures of erythroid activity.
Davies, S. V.; Fegan, C. D.; Kendall, R. et al

in Clinical & Laboratory Haematology (1995), 17(2), 139-44

Marked elevation of serum erythropoietin (sEPO) occurs following high dose chemotherapy for malignant disease. It has been proposed that the subsequent fall in sEPO constitutes a relative erythropoietin ... [more ▼]

Marked elevation of serum erythropoietin (sEPO) occurs following high dose chemotherapy for malignant disease. It has been proposed that the subsequent fall in sEPO constitutes a relative erythropoietin (EPO) deficiency, prompting trials of recombinant EPO to reduce red cell transfusion during chemotherapy. We have investigated these phenomena by serial estimations of reticulocytes and sEPO in 11 autologous marrow transplant recipients. sEPO reached two to five times baseline 0 to 5 days after transplant but the inverse relationship between sEPO and haematocrit was maintained. Observed to expected log sEPO (Epo ratio) rose and fell in parallel with sEPO, remaining greater than 1.0 throughout. A progressive fall in reticulocyte count during chemotherapy was followed by an increase during engraftment. The strong inverse relationships between reticulocytes and Epo ratio in the 10 days after initiating chemotherapy support the hypothesis that loss of EPO-receptor bearing erythroid precursors allows a rise in sEPO during chemotherapy. The elevation of Epo ratio levels during engraftment indicates that it is the availability of EPO-sensitive progenitors, rather than the supply of EPO, that limits the rate of resumption of erythropoiesis after high-dose chemotherapy. [less ▲]

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