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See detailA time–frequency technique for the stability analysis of impulse responses from nonlinear aeroelastic systems
Dimitriadis, Grigorios ULg; Cooper, Jonathan E

in Journal of Fluids & Structures (2003), 17(8), 11811201

A time–frequency method is proposed for the analysis of response time histories from nonlinear aeroelastic systems. The approach is based on a time-varying curve-fit of the short time Fourier transform of ... [more ▼]

A time–frequency method is proposed for the analysis of response time histories from nonlinear aeroelastic systems. The approach is based on a time-varying curve-fit of the short time Fourier transform of the impulse response. It is shown that the method can be used in order to obtain a clear picture of the sub-critical stability of a number of aeroelastic systems with a variety of structural and aerodynamic nonlinearities. Additionally, frequency and amplitude information can be obtained for both the linear and nonlinear signatures of the response signals in the sub- and postcritical regions. Finally, it is shown that, given certain types of nonlinear functions, sub-critical damping trends can be extrapolated to predict bifurcation airspeeds. [less ▲]

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See detailUn acte de mécénat d'Aubert Le Mire (1573-1640) en faveur des Dominicains de Bruxelles
Adam, Renaud ULg

in Revue du Cercle d'Histoire de Bruxelles et Extensions (2003), 79

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See detailCalculation of bovine haemoglobin oxygen saturation by algorithms integrating age, haemoglobin content, blood pH, partial pressures of oxygen and carbon dioxide in the blood, and temperature.
Detry, Benoit; Cambier, Carole ULg; Frans, A. et al

in Veterinary Journal (2003), 165(3), 258-265

In human and veterinary medicine, arterial and venous haemoglobin oxygen saturations are often used to estimate the severity of a disease and to guide therapeutic decisions. In veterinary medicine ... [more ▼]

In human and veterinary medicine, arterial and venous haemoglobin oxygen saturations are often used to estimate the severity of a disease and to guide therapeutic decisions. In veterinary medicine, haemoglobin oxygen saturation (SO(2)) is usually calculated using a blood gas analyser and algorithms developed for humans. It is possible, therefore, that the values obtained in animals may be distorted, particularly in animals with a high haemoglobin oxygen affinity, like young calves. In order to verify this hypothesis, we compared the arterial (SaO(2)) and venous (SvO(2)) haemoglobin oxygen saturations calculated using three different algorithms, and the oxygen exchange fraction (OEF) at the tissue level, which is the degree of haemoglobin desaturation between arterial and venous blood (SaO(2)-SvO(2)), with the values obtained from the whole bovine oxygen equilibrium curve (OEC) determined by a reference method. The blood gas analysers underestimated SvO(2) values; consequently, the OEF was overestimated (by about 10%). Two methods of reducing these errors were assessed. As the haemoglobin oxygen affinity decreases during the first month of life in calves a relationship between PO(2) at 50% haemoglobin saturation (P50) and age was established in order to correct the calculated values of venous and arterial SO(2), taking into account the estimated position of the OEC. This method markedly reduced the error for SvO(2) and OEF. Secondly, the SO(2) was calculated using a mathematical model taking into account the age of the animal and the specific effects of pH, PCO(2), and temperature on the bovine OEC. Using this method, the mean difference between the OEF values calculated using the mathematical model and those calculated by the reference method was close to zero. The errors produced by blood gas analysers can thus be minimised in two ways: firstly, by simply introducing a P50 estimated from the age of the calf into the analyser before the measurement; and secondly, by calculating the SO(2) using a mathematical model applied to the bovine OEC. [less ▲]

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See detailUn incunable de l'archevêque François Buisseret (1549-1615) : Réserve Précieuse de la Bibliothèque royale à Bruxelles, Inc B 1277
Adam, Renaud ULg

in Annales de la Société Archéologique de Namur (2003), 77

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See detailPathophysiology of type 2 diabetes.
Scheen, André ULg

in Acta Clinica Belgica (2003), 58(6), 335-41

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and ... [more ▼]

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions of beta-cell dysfunction and reduced insulin sensitivity to the pathogenesis of diabetes, it is generally agreed that both these factors play important roles. However, the mechanisms controlling the interplay of these two impairments are unclear. A number of factors have been suggested as possibly linking insulin resistance and beta-cell dysfunction in the pathogenesis of type 2 diabetes. A majority of individuals suffering from type 2 diabetes are obese, with central visceral adiposity. Therefore, the adipose tissue should play a crucial role in the pathogenesis of type 2 diabetes. Although the predominant paradigm used to explain this link is the portal/visceral hypothesis giving a key role in elevated non-esterified fatty acid concentrations, two new emerging paradigms are the ectopic fat storage syndrome (deposition of triglycerides in muscle, liver and pancreatic cells) and the adipose tissue as endocrine organ hypothesis (secretion of various adipocytokins, i.e. leptin, TNF-alpha, resistin, adiponectin, implicated in insulin resistance and possibly beta-cell dysfunction). These two paradigms constitute the framework for the study of the interplay between insulin resistance and beta-cell dysfunction in type 2 diabetes as well as between our obesogenic environment and diabetes risk in the next decade. [less ▲]

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See detailTwo-dimensional harmonic balance finite element modelling of electrical machines taking motion into account
Gyselinck, Johan; Dular, Patrick ULg; Vandevelde, Lieven et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2003), 22(4), 1021-1036

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system ... [more ▼]

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system of algebraic equations is derived by applying the Galerkin approach to both the space and time discretisation. The harmonic basis functions, i.e. a cosine and a sine function for each nonzero frequency and a constant function 1 for the DC component, are used for approximating the periodic time variation as well as for weighing the time domain equations in the fundamental period. In practice, this requires some elementary manipulations of the moving band stiffness matrix. Magnetic saturation and electrical circuit coupling are considered in the analysis as well. As an application example, the noload operation of a permanent-magnet machine is considered. The voltage and induction waveforms obtained with the proposed harmonic balance method are shown to converge well to those obtained with time stepping. [less ▲]

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULg et al

in Acta Crystallographica (2003)

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See detailMycoplasma bovis dans le complexe respiratoire bovin et propriétés de cyto-adhésion in vitro
Thomas, Anne; Dizier, Isabelle ULg; Sachse, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 267-272

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This ... [more ▼]

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This species was frequently isolated in Belgium from cattle with respiratory disease. Furthermore, associations were often observed with pasteurellas and bovine respiratory syncytial virus. Of these M. bovis isolates, many were resistant to several antimicrobial agents which are used in cattle practice, except to fluoroquinolones. Inasmuch the high frequency of M. bovis isolation and antibiotic resistances, it is very important to understand the pathogenicity of this bacteria in order to optimize prophylactic tools. Therefore, the study of the cytadherence of M. bovis is essential since it represents the first step of the bacterial infection. According to our experimental results, PG45 is not representative of field isolates because of its low adherence rates to various cell lines. This could be explained by the high number of subcultures of this pathogenic strain underwent since its first isolation, which sharply contrasts with other isolates. M. bovis adheres specifically to bovine bronchial epithelial cells in primary culture. Proteins such as variable surface proteins C and F are involved in this step as observed by decreased adherence rates after trypsinization of mycoplasma cells or addition of monoclonal antibodies. [less ▲]

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See detailAb initio study of MoS2 nanotube bundles
Verstraete, Matthieu ULg; Charlier, Jean-Christophe

in Physical Review. B : Condensed Matter (2003), 68

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See detailMaking sense of the industrial revolution, English economy and society 1700-1850.
Geerkens, Eric ULg

in Revue Belge de Philologie et d'Histoire (2003), 81(2), 519-521

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See detailCutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision.
Claessens, Nadine; Heymans, Olivier; Arrese Estrada, Jorge ULg et al

in American Journal of Clinical Dermatology (2003), 4(11), 799-802

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which ... [more ▼]

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which consists of various, but specific, tumors. OBJECTIVE: We report two cases of subcutaneous melanotic schwannoma localized on the trunk in two men aged 37 and 45 years. METHODS: Conventional histology and immunohistochemistry were performed. RESULTS: One melanotic schwannoma was associated with a cutaneous atypical myxoma and multiple melanocytic lesions, all being part of the Carney complex. The other case had no associated signs. In both cases, the melanotic schwannoma was completely excised and did not recur. CONCLUSION: Melanotic schwannoma is rare and curable by surgery. It must not be confused with malignant melanoma and other pigmented neoplasms. The Carney complex should be carefully ruled out. [less ▲]

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See detailEtudes des impacts hydrauliques, sédimentologiques et écologiques liés aux travaux hydrauliques sur la Semois
Gob, Frédéric; Houbrechts, Geoffrey ULg; Mols, Julien et al

in Belgeo (2003), 3

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux ... [more ▼]

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux, géomorphologiques et sédimentologiques. [less ▲]

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See detailGeneralized Pareto fit to the Society of Actuaries large claims database
Cebrian, Ana; Denuit, Michel; Lambert, Philippe ULg

in North American Actuarial Journal (2003), 7

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See detailSkin-lightening products revisited.
Petit, Ludivine; Pierard, Gérald ULg

in International Journal of Cosmetic Science (2003), 25(4), 169-81

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and ... [more ▼]

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and phaeomelanins are of utmost importance. These biomolecules result from the multi-step enzymatic and non-enzymatic conversion of tyrosine into melanins. Pigmentation disorders are multiple and depend on alterations in the density in active melanocytes, and on specific abnormalities of any of the complex melanogenesis mechanisms. This review presents some of the main skin-lightening agents with respect to their mechanisms of action and side-effects. Some of the novel compounds may lead to new perspectives in the fields of dermatology and cosmetology. The methods commonly used to assess efficacy of skin-lightening products rely on in vitro models including cell-free enzymatic assays, melanocyte cultures and reconstructed epidermis bioassays. Animal models have little relevance. By contrast, human testing with the support of instrumental evaluations is the most informative. [less ▲]

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See detailDownregulation of putative tumor suppressor gene TSC-22 in human brain tumors.
Shostak, Kateryna ULg; Dmitrenko, Vladimir V.; Garifulin, Oleg M. et al

in Journal of Surgical Oncology (2003), 82(1), 57-64

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and ... [more ▼]

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and human postnatal brain cDNA libraries was performed by differential hybridization with glioblastoma multiforme and human normal brain cDNAs. RESULTS: Repeated differential hybridization of more than 100 cDNA clones selected by primary screening and analysis of RNA from adult normal brain and glial tumors showed 16 nucleotide sequences differentially expressed between normal brain and brain tumors. Among others, decreased content in astrocytic tumors was determined for TSC-22 mRNA corresponding to cDNA in the ICRFp507J1041 clone from human fetal brain cDNA library. Northern blot hybridization of RNA from different human brain tumors showed very low amounts of TSC-22 mRNA in most investigated samples of GBM, anaplastic astrocytoma, and some other tumors. Complete lack of expression of TSC-22 occurred in one sample of anaplastic astrocytoma, as well as in meningioma, brain sarcoma, sarcomatous meningioma, and oligodendroglioma. The differential expression of TSC-22 gene was confirmed by semiquantitative RT-PCR in 15 samples of astrocytomas WHO grade II-IV and three samples of normal brain. CONCLUSIONS: Significantly decreased levels of TSC-22 mRNA in human brain and salivary gland tumors and antiproliferative role of TSC-22 strongly suggest a tumor suppressor role for TSC-22. J. [less ▲]

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See detailTopical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo.
Humbert, Philippe G; Haftek, Marek; Creidi, Pierre et al

in Experimental Dermatology (2003), 12(3), 237-44

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this ... [more ▼]

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this molecule as a potential candidate for use in the prevention and treatment of skin ageing. A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment. A double-blind, randomized trial was performed over a 6-month period, comparing the action of the vitamin C cream vs. excipient on photoaged skin. Clinical assessments included evaluation at the beginning and after 3 and 6 months of daily treatment. They were performed by the investigator and compared with the volunteer self assessment. Skin relief parameters were determined on silicone rubber replicas performed at the same time-points. Cutaneous biopsies were obtained at the end of the trial and investigated using immunohistochemistry and electron microscopy. Clinical examination by a dermatologist as well as self-assessment by the volunteers disclosed a significant improvement, in terms of the 'global score', on the vitamin C-treated side compared with the control. A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and well-tolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing. [less ▲]

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See detailCaractérisation génotypique de souches invasives aviaires d'Escherichia coli isolées en Belgique
Stordeur, P.; Beaupain, N.; Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 275-280

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See detailThe HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity.
Basbous, Jihane; Arpin, Charlotte; Gaudray, Gilles ULg et al

in Journal of Biological Chemistry (2003), 278(44), 43620-7

The human T-cell leukemia virus type I (HTLV-I)-encoded Tax protein activates transcription from the viral promoter via association with the cellular basic leucine zipper factor cAMP-response element ... [more ▼]

The human T-cell leukemia virus type I (HTLV-I)-encoded Tax protein activates transcription from the viral promoter via association with the cellular basic leucine zipper factor cAMP-response element-binding protein-2. Tax is also able to induce cellular transformation of T lymphocytes probably by modulating transcriptional activity of cellular factors, including nuclear factor-kappaB, E2F, activator protein-1 (AP-1), and p53. Recently, we characterized in HTLV-I-infected cells the presence of a novel viral protein, HBZ, encoded by the complementary strand of the HTLV-I RNA genome (Gaudray, G., Gachon, F., Basbous, J., Biard-Piechaczyk, M., Devaux, C., and Mesnard, J.-M. (2002) J. Virol. 76, 12813-12822). HBZ is a nuclear basic leucine zipper protein that down-regulates Tax-dependent viral transcription by inhibiting the binding of cAMP-response element-binding protein-2 to the HTLV-I promoter. In searching for other cellular targets of HBZ, we identified two members of the Jun family, JunB and c-Jun. Co-immunoprecipitation and cellular colocalization confirmed that HBZ interacts in vivo with JunB and c-Jun. When transiently introduced into CEM cells with a reporter gene containing the AP-1 site from the collagenase promoter, HBZ suppressed transactivation by c-Jun. On the other hand, the combination of HBZ with Jun-B had higher transcriptional activity than JunB alone. Consistent with the structure of its basic domain, we demonstrate that HBZ decreases the DNA-binding activity of c-Jun and JunB. Last, we show that c-Jun is no longer capable of activating the basal expression of the HTLV-I promoter in the presence of HBZ in vivo. Our results support the hypothesis that HBZ could be a negative modulator of the Tax effect by controlling Tax expression at the transcriptional level and by attenuating activation of AP-1 by Tax. [less ▲]

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See detailL'air du temps : Un souffle d'oxygène pour des collections d'horlogerie
Drouguet, Noémie ULg

in Art&Fact (2003), 22

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See detailnote sous arrêt du 23 octobre 2003, Van den Bergh Foods contre Commission
Petit, Nicolas ULg

in Revue du Droit de l'Union Européenne (2003)

résumé et analyse de l'affaire Volkswagen AG contre Commission, affaire C-338/00

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See detailFirst-principles calculation of the band offset at BaO/BaTiO3 and SrO/SrTiO3 interfaces
Junquera, J.; Zimmer, M.; Ordejon, P. et al

in Physical Review. B, Condensed Matter and Materials Physics (2003), 67

We report first-principles density-functional pseudopotential calculations on the atomic structures, electronic properties, and band offsets of BaO/BaTiO3 and SrO/SrTiO3 nanosized heterojunctions grown on ... [more ▼]

We report first-principles density-functional pseudopotential calculations on the atomic structures, electronic properties, and band offsets of BaO/BaTiO3 and SrO/SrTiO3 nanosized heterojunctions grown on top of a silicon substrate. The density of states at the junction does not reveal any electronic induced interface states. A dominant perovskite character is found at the interface layer. The tunability of the band offset with the strain conditions imposed by the substrate is studied. Using previously reported theoretical data available for Si/SrO, Si/BaO, SrTiO3/Pt, and BaTiO3/SrRuO3 interfaces we extrapolate the band alignments along two gate stacks of technological interest: Si/SrO/SrTiO3/Pt and Si/BaO/BaTiO3/SrRuO3 heterostructures. [less ▲]

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See detailTreatment failures and relapses in onychomycosis: a stubborn clinical problem.
Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 207(3), 255-60

The therapeutic outcome of onychomycoses is uncertain. Comparative short-term efficacy studies on antifungals abound and report contradictory findings. Few unbiased follow-up studies have scrutinized the ... [more ▼]

The therapeutic outcome of onychomycoses is uncertain. Comparative short-term efficacy studies on antifungals abound and report contradictory findings. Few unbiased follow-up studies have scrutinized the long-term outcome. Basically, none of the current antifungals can guarantee cure in all instances. In addition, relapses are not rare. The causes of therapeutic failure in onychomycoses are multiple. The most important are the lack of diagnostic accuracy, inadequate antifungal choice or delivery modality, and presence of dormant conidia, sequestrated mycelium pockets or resistant fungal species. The concept of fungicidal drug derived from selected in vitro studies appears irrelevant in clinical practice. [less ▲]

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See detail'Aangewaaid uit een vreemd land': de westerse poëzie van G.J. Resink
Steyaert, Kris ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2003), 119(4), 279-299

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have ... [more ▼]

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have very much focused on what they perceive to be 'eastern' elements in Resink's oeuvre. I maintain that this has resulted in a one-sided interpretation, neglecting the underlying western, and in particular Dutch, tradition in many of Resink's poems. This article demonstrates the different ways in which Resink drew on the principles and literary output of the Eighties Movement, and how his formal experiments gain in significance when set against the work of poets like Perk, Kloos, and Dèr Mouw. The general view on Resink's later work as being inferior to his earlier poetry is shown to be the result of unwarranted preconceptions. [less ▲]

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See detailIn vitro stability and immunoreactivity of the native and recombinant plant food 2S albumins Ber e 1 and SFA-8
Murtagh, M.; Archer, D.; Dumoulin, Mireille ULg et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2003), 8

Background The ability of an intact protein to reach the circulatory system may be a prerequisite to allergenicity and many allergens, particularly those from plant foods, have been found to be ... [more ▼]

Background The ability of an intact protein to reach the circulatory system may be a prerequisite to allergenicity and many allergens, particularly those from plant foods, have been found to be consistently more resistant to digestion by pepsin than other proteins. Objective This study assessed the pepsinolytic stability of native 2S albumins from Brazil nut and sunflower seed and their recombinant versions produced in Pichia pastoris. The physicochemical stability of native and recombinant Brazil nut 2S albumins and recombinant sunflower seed 2S albumin was also assessed. The immunoreactivity of native Brazil nut 2S albumin and recombinant 2S albumins was compared using serum from patients allergic to Brazil nuts and animals immunized with native 2S albumins. Methods Digestibility was measured in simulated gastric fluid followed by SDS-PAGE. Circular dichroism spectra were used to analyse unfolding, as proteins were denatured by temperature, pH and guanidinium chloride. Immunoreactivity was assessed by immunoblot, RAST and ELISA. Results Brazil nut 2S albumin was significantly more resistant to proteolytic digestion than other Brazil nut proteins. It was also resistant to thermally and chemically induced denaturation. Equally high resistance to proteolytic digestion was observed with sunflower seed 2S albumin. The recombinant albumins mirrored their native counterparts in stability and immunoreactivity. Conclusion The important food allergen Brazil nut 2S albumin is as stable to digestion as is sunflower seed 2S albumin, whose allergenicity has yet to be determined. The 2S albumins and their recombinant counterparts could not be easily denatured by physicochemical treatments. The results suggest that 2S albumin is the only Brazil nut protein to reach the gut immune system intact. The production of properly folded recombinant proteins will facilitate mechanistic studies as well as diagnostic testing and antigen-based therapies. [less ▲]

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See detailChanges in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine.
Legssyer, Rachida; Josse, Claire ULg; Piette, Jacques ULg et al

in Journal of Inorganic Biochemistry (2003), 94(1-2), 36-42

Both desferrioxamine (DFO) and chloroquine can significantly reduce hepatic iron in experimental animals with iron overload by chelating iron from the low-molecular-weight pool or decreasing iron uptake ... [more ▼]

Both desferrioxamine (DFO) and chloroquine can significantly reduce hepatic iron in experimental animals with iron overload by chelating iron from the low-molecular-weight pool or decreasing iron uptake by the transferrin-transferrin receptor cycle, respectively. However, no previous studies have investigated whether combination therapy of these two drugs would further decrease the tissue iron overload as well as iron-induced toxicity. Chloroquine administration, 15 mg/kg, 5x/week, to rats during the iron loading regime, 10 mg/kg, 3x/week for 4 weeks, significantly decreased both hepatic (54%) and macrophage iron content (24%). However when administered in combination with desferrioxamine, 10 mg/kg, 3x/week for 2 weeks at the cessation of iron loading, no further reduction of hepatic iron content was noted while the iron content of the macrophages significantly increased, possibly indicating the flux of ferrioxamine through these cells. Further studies are warranted to investigate the speciation of iron within these macrophages. Macrophages isolated from chloroquine-treated iron loaded rats showed a reduction in latent NFkappaB activation and a significant increase in lipopolysaccharide-stimulated nitrite release by comparison to these parameters in iron loaded macrophages. Co-administration of chloroquine and desferrioxamine normalised the latent activity of NFkappaB to that of control macrophages as well as increasing LPS-stimulated NO release towards control values. However, DFO alone did not have any significant effect upon either of these parameters. Such results may have important relevance for the reduced immune function of iron loaded macrophages isolated from thalassaemia patients receiving chelation therapy and their propensity to increased infection. [less ▲]

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See detailEthique de la régulation, régulation par l'éthique
Geuens, Geoffrey ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2003), 97-98-99 ("Éthique et pouvoir des médias")

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See detailIntérêt du monitoring continu du glucose interstitiel chez le patient diabétique de type 1
RADERMECKER, Régis ULg; Sélam, Jean-Louis; SCHEEN, André ULg

in Revue Médicale Suisse (2003), 61

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See detailUltrasound appearance of bowel wall in Wolman's disease.
NCHIMI LONGANG, Alain ULg; Rausin, Leon; Khamis, Jamil

in Pediatric Radiology (2003), 33(4), 284-5

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See detailThe Tellnes ilmenite deposit (Rogaland, South Norway): magnetic and petrofabric evidence for emplacement of a Ti-enriched noritic crystal mush in a fracture zone
Diot, Hervé; Bolle, Olivier ULg; Lambert, Jean-Marc et al

in Journal of Structural Geology (2003), 25(4), 481-501

The Tellnes ilmenite deposit, a world class titanium deposit, occurs in the Ana-Sira anorthosite (Rogaland anorthosite province, South Norway). It is mainly made up of an ilmenite-rich norite that has ... [more ▼]

The Tellnes ilmenite deposit, a world class titanium deposit, occurs in the Ana-Sira anorthosite (Rogaland anorthosite province, South Norway). It is mainly made up of an ilmenite-rich norite that has been previously interpreted as injected in a crystal mush state, in a weakness zone of the enclosing anorthosite. This emplacement mechanism has produced a faint orientation in the ore due to the flow of the mush. The internal flow structure of the orebody is studied here using the low-field anisotropy of magnetic susceptibility (AMS) method. Partial anhysteretic remanent magnetization (pAARM) indicates that coarse magnetite is the main mineral responsible for the magnetic fabric. Parallelism of the magnetic fabric with the shape-preferred orientation of the ore-forming minerals is checked using image analysis (IA) from oriented sections (intercept method). Interpretation of the AMS data verified by pAARM and IA, provides information on the magmatic foliation and lineation. Emplacement flow of the ilmenite norite crystal mush occurred in the direction of the orebody, parallel to its walls, and with an average SE 18degrees plunge. The feeder zone was likely situated below a network of veins on the SE end of the orebody. The sickle-shaped outcrop of the deposit suggests a transcurrent, dextral opening of a WNW-ESE-striking weakness zone across the anorthosite pluton. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailEffect of rival males on the courtship of paedomorphic and metamorphic Triturus alpestris (Amphibia : Salamandridae)
Denoël, Mathieu ULg

in Copeia (2003), 2003(3), 618-623

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and ... [more ▼]

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and salamanders is a suitable process to explore this question because it implies the coexistence of two different morphological morphs differing by the presence of gills and epigamic traits. The aim of this study was to find out whether paedomorphs and metamorphs use similar tactics to attract mates in the presence of a rival and whether there are differences in sexual activity and success between alternative morphs. Sexual interactions in triadic encounters were staged and analyzed in a standardized experimental design. The two kinds of males did not differ in terms of sexual activity, spermatophore deposition or female responsiveness. Both rival paedomorphic and metamorphic males exhibited sexual interference, but in most encounters, intruders just disturbed the courting pair. Sperm transfer success was lower in triadic encounters than in dyadic encounters. These results illustrate that intermorph breeding also occurs in the presence of competitors but that the success rate of the newts is considerably decreased in such competitive situations. Moreover, newts do not use alternative reproductive tactics depending on their status (i.e., paedomorph or metamorph). [less ▲]

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See detailThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
Valdes Socin, Hernan Gonzalo ULg; Chanson, Philippe; Delemer, B. et al

in European Journal of Endocrinology (2003), 148(4), 433-442

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 ... [more ▼]

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 male and 20 female) among 4400 pituitary adenomas followed between 1976 and 2001 in six Belgian and French centers. RESULTS: TSH was elevated in 18/43 and alpha subunit in 13/32 patients. In patients with intact thyroid (n=30), mean free tri-iodothyronine was 13.1 pmol/l (range 3.5-23) and mean free thyroxine was 38.4 pmol/l (range 10.2-62.7). Hyperprolactinemia and acromegaly were associated in 9/43 and 8/43 cases. The number of associated hypersecretions was higher in macroadenomas than in microadenomas (Chi square = 11.2, P<0.01). Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome. The proportion of microadenomas versus macroadenomas was 1/11 (period 1974-1986) and 8/32 (period 1987-2001). Bilateral petrosal sinus sampling, (111)In-pentreotide scintigraphy and ((11)C)-l-methionine positron emission tomography scan confirmed diagnosis in four questionable microadenomas. Macroadenomas with extrasellar extension (31 cases) had a tendency to be medially located. Medical treatment with somatostatin analogs was initiated as first-line treatment in 26 patients. TSH levels were reduced by more than 50% in 23/26 cases. A tumoral shrinkage of more than 20% was observed in 5/13 cases. Surgery was performed in 36 patients. After 1 year, 21 of them (58.3%) met the criteria of surgical favorable outcome. Pituitary radiotherapy (n=8) and somatostatin analogs allowed normalization in cases not cured by surgery. CONCLUSION: Ultrasensitive methods for TSH measurement led to an earlier recognition of TSH-secreting pituitary tumors. In this series, we observed that TSH-secreting pituitary tumors are today more frequently found at the stage of microadenomas, medially located, without associated hypersecretions and needing new exploration methods as compared with older series. This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease. [less ▲]

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See detailTransfigurative Art: Wilson Harris's The Mask of the Beggar
Maes-Jelinek, Hena ULg

in Moving Worlds : A Journal of Transcultural Writings (2003), 3(2), 12-26

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See detailTwo distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications
Terrak, Mohammed ULg; Wu, G.; Stafford, W. F. et al

in EMBO Journal (2003), 22(3), 362-71

IQ motifs are widespread in nature. Mlc1p is a calmodulin-like myosin light chain that binds to IQ motifs of a class V myosin, Myo2p, and an IQGAP-related protein, Iqg1p, playing a role in polarized ... [more ▼]

IQ motifs are widespread in nature. Mlc1p is a calmodulin-like myosin light chain that binds to IQ motifs of a class V myosin, Myo2p, and an IQGAP-related protein, Iqg1p, playing a role in polarized growth and cytokinesis in Saccharomyces cerevisiae. The crystal structures of Mlc1p bound to IQ2 and IQ4 of Myo2p differ dramatically. When bound to IQ2, Mlc1p adopts a compact conformation in which both the N- and C-lobes interact with the IQ motif. However, in the complex with IQ4, the N-lobe no longer interacts with the IQ motif, resulting in an extended conformation of Mlc1p. The two light chain structures relate to two distinct subfamilies of IQ motifs, one of which does not interact with the N-lobes of calmodulin-like light chains. The correlation between light chain structure and IQ sequence is demonstrated further by sedimentation velocity analysis of complexes of Mlc1p with IQ motifs from Myo2p and Iqg1p. The resulting 'free' N-lobes of myosin light chains in the extended conformation could mediate the formation of ternary complexes during protein localization and/or partner recruitment. [less ▲]

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : II) Franchissement des muqueuses et propriétés invasives
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2003), 147(3, JUN-JUL), 159-171

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, entero-haemorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains : adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This second manuscript presents the current knowledge on the transmucosal transfer, resistance to the bactericidal activity of the complement, resistance to phagocytosis and production of colicins, that were, for several years, considered as an important specific property of invasive strains of E coli. [less ▲]

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See detailWithin-herd effects of age at test day and lactation stage on test-day yields
Bormann, J.; Wiggans, G. R.; Druet, Tom ULg et al

in Journal of Dairy Science (2003), 86(11), 3765-3774

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve ... [more ▼]

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve the accuracy of estimation. Test-day data starting with 1990 calvings for the entire US Jersey population and Holsteins from California, Pennsylvania, Wisconsin, and Texas were analyzed. Test-day yields were adjusted for across-herd effects using solutions from a regional analysis. Estimates of the relative variance ( fraction of total variance) due to within-herd age effects were small, indicating that regional adjustments for age were adequate. The relative variances for within-herd lactation stage were large enough to indicate that accuracy of genetic evaluations could be improved by including herd stage effects in the model for milk, fat, and protein, but not for somatic cell score. Because the within-herd lactation stage effect is assumed to be random, the effect is regressed toward the regional effects for small herds, but in large herds, lactation curves become herd specific. Model comparisons demonstrated the greater explanatory power of the model with a within-herd-stage effect as prediction error standard deviations were greater for the model without this effect. The benefit of the within-herd-stage effects was confirmed in a random regression model by comparing variance components from models with and without random within-herd regressions and through log-likelihood ratio tests. [less ▲]

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See detailDerivation of the 1.0-0.9 Ga ferro-potassic A-type granitoids of southern Norway by extreme differentiation from basic magmas
Vander Auwera, Jacqueline ULg; Bogaerts, Michel; Liégeois, Jean-Paul ULg et al

in Precambrian Research (2003), 124(2-4), 107-148

Major and trace elements, Sr and Nd isotopic data as well as mineral compositions are presented for a selection of the 1.0 - 0.9 ferro-potassic A-type granitoids (Bessefjellet, Rustfjellet ... [more ▼]

Major and trace elements, Sr and Nd isotopic data as well as mineral compositions are presented for a selection of the 1.0 - 0.9 ferro-potassic A-type granitoids (Bessefjellet, Rustfjellet, Verhuskjerringi, Valle, Holum, Svöfjell, Handeland-Tveit, Åseral, Lyngdal gabbronorites) that occur close to the Mandal-Ustaoset Line of southern Norway. These hornblende biotite granitoids (HBG) define an extensive differentiation trend ranging from gabbronorites (50 wt % SiO2) to granites (77 wt % SiO2). This trend is interpreted as resulting from extreme fractional crystallization of several basaltic magma batches with similar major and trace elements compositions. At 930 Ma, the HBG suite displays a narrower range in ISr (0.7027 - 0.7056) than in Nd(t) (+1.97 down to -4.90) suggesting some assimilation of a Rb-depleted lower crust (AFC process) or/and source variability. An age of 929 ± 47 Ma is given by a Rb-Sr isochron on the Holum granite (Sri = 0.7046 ±0.0006, MSWD = 1.7). Geothermobarometers indicate a low pressure of emplacement (1.3-2.7 kbar) and an oxygen fugacity close to NNO. High liquidus temperatures are given by the apatite saturation thermometer (1005°C to 1054 °C) and are in agreement with results from other studies. The basaltic parent magmas of the HBG suite are partial melts of an hydrous mafic, potassic source lying either in the lithospheric upper mantle or in the mafic lower crust derived from it. This contrasts with the 930 Ma anorthosite-mangerite-charnockite suite (AMC) of the Rogaland Province for which a depleted lower crustal anhydrous gabbronoritic source has been indicated. The present data imply the penecontemporaneous melting of two contrasting sources in southern Norway. The source duality could result from an increasing degree of metamorphism (amphibolite to granulite) from East to West, an horizontal stratification of the lower crust or from the stratification of the lithosphere (melting of the lower crust or upper mantle). It may also indicate that the AMC and HBG suites formed in two distinct crustal segments. The linear alignment of the HBG suite along the Mandal-Ustaoset shear zone suggests that a linear uprise of the asthenosphere, following a lithospheric delamination under this structure, could be the vector of the mantle heat. [less ▲]

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See detailPrediction of technological and organoleptic properties of beef Longissimus thoracis from near-infrared reflectance and transmission spectra
Leroy, Bernadette ULg; Lambotte, S.; Dotreppe, Olivier ULg et al

in Meat Science (2003), 66(1), 45-54

Technological and organoleptic properties of beef cuts were predicted by near-infrared (NIR) spectroscopy. Spectra were collected on 189 beef Longissimus thoracis muscle samples using, transmission (NIRT ... [more ▼]

Technological and organoleptic properties of beef cuts were predicted by near-infrared (NIR) spectroscopy. Spectra were collected on 189 beef Longissimus thoracis muscle samples using, transmission (NIRT) and reflectance with a probe. Quality assessment and NIR recordings were performed on sliced loin after 2 and 8 days ageing. Partial least squares regression yielded determination coefficients of cross-validation (R-cv(2)) of 0.12-0.25 for the prediction of Warner-Bratzler Peak Shear Force in reflectance and 0.15-0.41 in transmission. Higher R-cv(2) were obtained for L* parameter (0.83-0.85), a* (0.39-0.49) and b* (0.73-0.75) with reflectance. Predictions of drip loss and cooking loss were less accurate with a R-cv(2) range of 0.38 to 0.54 and 0.25 to 0.47, respectively. The NIR spectra collected on fresh meat show good potential to predict CIE L* and b* parameters in reflectance mode. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailThe Nucleon-Nucleon Problem in Quark Models
Stancu, Floarea ULg

in Few-Body Systems (2003), 14

In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from ... [more ▼]

In the first part we summarize the status of the nucleon-nucleon (NN) problem in the context of Hamiltonian based constituent quark models and present results for the $\ell = 0$ phase shifts obtained from the Goldstone-boson exchange model by applying the resonating group method. The second part deals with the construction of local shallow and deep equivalent potentials based on a Superymmetric Quantum Mechanics approach. [less ▲]

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See detailHepatitis C: screening, treatment and prevention practical guidelines
Michielsen, P.; Brenard, R.; Bourgeois, N. et al

in Acta Gastro-Enterologica Belgica (2003), 66(1), 15-19

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the ... [more ▼]

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the hepatitis C virus (HCV) load and a better response rate. Naive chronically infected HCV patients (n = 454) were randomized into two arms to receive either induction treatment with interferon alpha 2b 5 million units (MU) subcutaneously (s.c.) daily during a period of 8 weeks (arm A); or treatment with interferon alpha 2b 5 MU s.c. three times a week (TIW) for a period of 8 weeks (arm B). After week 8, interferon treatment in both arms was 3 MU s.c. TIW for a total period of 12 months. In both arms, ribavirin (1000-1200 mg orally per day) was added at week 4. Induction treatment resulted in a higher virological response at week 8 of treatment (66%vs 47%; P < 0.01). However, response at the end of treatment and at 6 months follow-up was not different (53%vs 50%, 41%vs 33%). The occurrence of adverse events and the drop-out rate were similar in both arms. Although an early virological response is observed more frequently in the induction treatment, end of treatment response and sustained responses did not differ [less ▲]

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See detailDes statines pour le cerveau?
Sadzot, Bernard ULg; HANS, Grégory ULg; Bottin, P. et al

in Revue Médicale de Liège (2003), 58(10), 621-7

Whether cholesterol lowering decreases risk of stroke has long remained unclear. Large epidemiological studies have found only weak links between cholesterol levels and stroke. Recent studies with statins ... [more ▼]

Whether cholesterol lowering decreases risk of stroke has long remained unclear. Large epidemiological studies have found only weak links between cholesterol levels and stroke. Recent studies with statins, more potent cholesterol lowering agents, have now demonstrated significant reductions of stroke incidence and total mortality when administered for secondary prevention in patients with wide ranges of cholesterol values. It remains unknown if a statin is superior to others for the secondary prevention of stroke. [less ▲]

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See detailA note on stability, robustness and performance of output feedback nonlinear model predictive control
Imsland, Lars; Findeisen, Rolf; Bullinger, Eric ULg et al

in Journal of Process Control (2003), 13(7), 633-644

In recent years. nonlinear model predictive control (NMPC) schemes have been derived that guarantee stability of the closed loop under the assumption of full state information. However, only limited ... [more ▼]

In recent years. nonlinear model predictive control (NMPC) schemes have been derived that guarantee stability of the closed loop under the assumption of full state information. However, only limited advances have been made with respect to output feedback in the framework of nonlinear predictive control. This paper combines stabilizing instantaneous state feedback NMPC schemes with high-gain observers to achieve output feedback stabilization. For a uniformly observable MIMO system class it is shown that the resulting closed loop is asymptotically stable. Furthermore, the output feedback NMPC scheme recovers the performance of the state feedback in the sense that the region of attraction and the trajectories of the state feedback scheme can be recovered to any degree of accuracy for large enough observer gains, thus leading to semi-regional results. Additionally, it is shown that the output feedback controller is robust with respect to static sector bounded nonlinear input uncertainties. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailOrigin and evolution of Precambrian Anorogenic Magmatism
Vander Auwera, Jacqueline ULg; Martin, Hervé; Rämö, Tapani

in Precambrian Research (2003), 124(2-4), 105-344

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See detailE lectron–phonon couplings at C60 interfaces: a case study by two- color, infrared–visible sum–frequency generation spectroscopy
Caudano, Yves; Silien, C.; Humbert, Christophe et al

in Journal of Electron Spectroscopy & Related Phenomena (2003), 129

We demonstrate the ability of doubly resonant sum–frequency generation (DR-SFG) to investigate electron–phonon couplings at C60 –metal interfaces. Due to its coupling to electronic transitions, the ... [more ▼]

We demonstrate the ability of doubly resonant sum–frequency generation (DR-SFG) to investigate electron–phonon couplings at C60 –metal interfaces. Due to its coupling to electronic transitions, the totally symmetric Ag(2) vibration of C60 exhibits a huge enhancement of its nonlinear response for sum–frequency energies above the molecular electronic gap. We attribute this resonance to the coupling of the pentagonal pinch mode with the tiu lowest unoccupied molecular orbital (LUMO) of C60. [less ▲]

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See detailModulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene.
Grobet, Luc ULg; Pirottin, Dimitri ULg; Farnir, Frédéric ULg et al

in Genesis (2003), 35(4), 227-38

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular ... [more ▼]

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. [less ▲]

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See detailLa sentence arbitrale
Caprasse, Olivier ULg

in Actualités du Droit (2003), 3

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See detailFunctional neuroimaging of auditory processing
Laureys, Steven ULg; Salmon, Eric ULg; Goldman, Serge et al

in Acta Oto-Rhino-Laryngologica Belgica (2003), 57(4), 267-273

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm ... [more ▼]

There is a complex functional organization of the central auditory system from the brainstem to primary and associative auditory cortices. Functional neuroimaging has been used to visualize and confirm the spatial distribution of brain activation in temporal areas for the processing of simple acoustic stimuli. Brain activity is much more complex for words, and different networks can be recruited when phonological, lexical and semantic levels of processing are engaged. [less ▲]

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See detailCompte-rendu de l'ouvrage de I. Loudon (ed.) : Western Medicine. An Illustrated History
Nissen, Cécile ULg

in Archives Internationales d'Histoire des Sciences (2003)

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See detailLa géographie économique, Cent ans de géographie à l’Université de Liège, 1903-2003
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (2003), (43), 111-119

100 years of economic geography at the University of Liege

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See detailModel Updating Based on Frequency Response Functions Using A General Finite Element Code
Yan, Ai-Min; Golinval, Jean-Claude ULg

in European Journal of Mechanical and Environmental Engineering (2003), 48(3), 149-162

Model updating techniques using frequency response function (FRF) data are studied in this paper. The numerical techniques are discussed for implementation with a large commercial finite element (FE ... [more ▼]

Model updating techniques using frequency response function (FRF) data are studied in this paper. The numerical techniques are discussed for implementation with a large commercial finite element (FE ) code. System equivalent reduction expansion process is adopted to reduce the complete FE solutions onto the experimental degrees of freedom. The rank-deficiency difficulty with this method is overcome using either of two numerical techniques: diagonal perturbation and singular value decomposition. This second technique is also used in solving the updating equation. Experimental FRF data are compared with the FE solutions, and the updated model parameters are obtained via an iteration procedure. A simplified frequency domain assurance criterion is proposed to evaluate the correlation between the FE model and the measured structure at the chosen frequencies. After verifying the efficiency of the methods with several benchmark tests, the program is applied to an aeroplane model test. Some conclusions are given and remaining problems illustrated. [less ▲]

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See detailEfficacité du piégeage, par les méthodes classiques, des coléoptères saproxyliques en Région wallonne (Belgique)
Lhoir, Jonathan; Fagot, Jean ULg; Thieren, Yves et al

in Notes Fauniques de Gembloux (2003), 50

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont ... [more ▼]

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont (Daverdisse village). Both forests are caracterized by a large amount of dead wood standing and laying down. The trapping's results are presented, with regards on the different technics used, on the differences between sites, on the beetles families and their saproxylic behavior. [less ▲]

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See detailThe Prose Poem Now
Delville, Michel ULg; Alkhateeb, Tahseen

in AL-QUDS Al-arabi (2003)

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See detailEstado, mercado y diversidad cultural
Martiniello, Marco ULg

in Revista de Occidente (Madrid, Spain : 1923) (2003), 268

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See detailBiosynthesis of defensive compounds from beetles and ants
Laurent, Pascal ULg; Braekman, Jean-Claude; Daloze, Désiré et al

in European Journal of Organic Chemistry (2003), 15

Many beetle and ant species owe their protection against predators to the presence of defensive compounds in their hemolymph or in specialized exocrine glands. A growing number of studies devoted to the ... [more ▼]

Many beetle and ant species owe their protection against predators to the presence of defensive compounds in their hemolymph or in specialized exocrine glands. A growing number of studies devoted to the elucidation of the biosynthetic pathways used by the insects to produce these compounds have been reported in recent years. An over-view of these studies is presented. [less ▲]

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See detailNF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells
Bentires-Alj, Mohamed; Barbu, Véronique; Fillet, Marianne ULg et al

in Oncogene (2003), 22

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and ... [more ▼]

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and neoplastic cells often develop multiple mechanisms of drug resistance during tumor progression. We observed that NF-kappaB or P-glycoprotein inhibition in the HCT15 colon cancer cells led to increased apoptotic cell death in response to daunomycin treatment. Interestingly, NF-kappaB inhibition through transfection of a plasmid coding for a mutated IkappaB-alpha inhibitor increased daunomycin cell uptake. Indeed, the inhibition of NF-kappaB reduced mdr1 mRNA and P-glycoprotein expression in HCT15 cells. We identified a consensus NF-kappaB binding site in the first intron of the human mdr1 gene and demonstrated that NF-kappaB complexes could bind with this intronic site. Moreover, NF-kappaB transactivates an mdr1 promoter luciferase construct. Our data thus demonstrate a role for NF-kappaB in the regulation of the mdr1 gene expression in cancer cells and in drug resistance. [less ▲]

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Delarge, J. et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003)

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See detailFormulation of submicronic emulsions by using a high-pressure homogeniser
Roland, I; Evrard, Brigitte ULg; Erpicum, T et al

in Journal de Pharmacie de Belgique (2003), 57

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See detailRecherche et dosage des résidus de DDT dans le sérum
Charlier, Corinne ULg

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2003), 18

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See detailNew ruthenium catalysts bearing N-heterocyclic carbene ligands for ATRA and ATRP
Sauvage, Xavier ULg; Richel, Aurore ULg; Delfosse, Sébastien et al

in e-polymers (2003)

This study provides a glimpse of the synthetic possibilities arising from the use of NHC􀀀 s complexes in radical reactions, and illustrates how the fine tuning of the steric and electronic parameters of ... [more ▼]

This study provides a glimpse of the synthetic possibilities arising from the use of NHC􀀀 s complexes in radical reactions, and illustrates how the fine tuning of the steric and electronic parameters of this class of ruthenium complexes affect their catalytic activity. [less ▲]

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See detailLa PESC à l'épreuve de la crise irakienne
Petermann, Simon ULg; Matagne, Geoffroy ULg

in La cittadinanza europea (2003)

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See detailPour lire Pédigrée
Dumortier, Jean-Louis ULg

in Dossiers L (Littérature française de Belgique (2003), 64(4),

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See detailEffet des bordures de champs sur les populations de Chrysopes [Neuroptera: Chrysopidae] en cultures maraîchères
Mignon, Jacques ULg; Colignon, Pierre; Haubruge, Eric ULg et al

in Phytoprotection (2003), 84(2), 121-128

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and ... [more ▼]

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and Coccinellidae is well known but very few studies have been realised to assess its effect on the abundance and diversity of Chrysopidae. In 2000 and 2001, the impact of adjacent habitats on lacewing populations was investigated in both carrot and broad bean open fields. Three types of field borders were selected: (1) set-asides mainly composed by Lolium perenne and Trifolium spp., (2) crops (wheat, beet or other vegetables) and (3) woody areas (mixture of Acer sp., Populus sp. and Salix sp.). Insects were caught using yellow pan traps. Chrysopidae populations were shown to be significantly lower in carrot and broad bean fields bordered with woodland. Lacewing and other Neuroptera species richness were always low and were discussed in relation with their role of pest predators associated with other aphidophagous insects. [less ▲]

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See detailRecent developments in 5-lipoxygenase inhibitors
Julémont, F.; Dogné, J.-M.; Laeckmann, D. et al

in Expert Opinion on Therapeutic Patents (2003), 13

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See detailSyncope sur passage en tachycardie ventriculaire par accélération d’une fibrillation auriculaire
Guillaume, T.; Melon, Pierre ULg; Bouffioux, Laurent ULg et al

in Revue Médicale de Liège (2003), 58(7-8), 468-471

We report a rare case of rapid atrial fibrillation triggering an episod of ventricular tachycardia. We review the literature and discuss the potential mechanisms of the ventricular arrhythmia.

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See detailTierce décision obligatoire et violation d'une règle de procédure conventionnellement arrêtée par les parties
Caprasse, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailMMP-2 and MMP-9 synergize in promoting choroidal neovascularization
Lambert, Vincent ULg; Wielockx, B.; Munaut, Carine ULg et al

in FASEB Journal (2003), 17(15), 2290-2292

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but ... [more ▼]

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but their precise role and potential interactions remain unclear. To address the question of MMP-2 and MMP-9 functions, mice deficient in the expression of MMP-2 (MMP-2 KO), MMP-9 (MMP-9 KO), and both MMP-2 and MMP-9 (MMP-2,9 KO) with their corresponding wild-type mice (WT) underwent CNV induction by laser-induced rupture of the Bruch's membrane. Both the incidence and the severity of CNV were strongly attenuated in double deficient compared with single gene deficient mice or corresponding WT controls. The reduced neovascularization was accompanied by fibrinogen/fibrin accumulation. Furthermore, overexpression of the endogenous MMP inhibitors TIMP-1 or TIMP-2 (delivered by adenoviral vectors) in WT mice or daily injection of a synthetic and gelatinase selective MMP inhibitor (Ro 26-2853) significantly decreased the pathological reaction. These findings suggest that MMP-2 and MMP-9 may cooperate in the development of AMD and that their selective inhibition represents an alternative strategy for the treatment of choroidal neovascularization. [less ▲]

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See detailDesign and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis
Meunier, P. J.; Reginster, Jean-Yves ULg

in Osteoporosis International (2003), 14(Suppl. 3), 66-76

The phase 3 program for strontium ranelate, a new oral agent in the treatment of women with postmenopausal osteoporosis, was aimed to assess the efficacy and safety of the daily oral dose of 2 g. This ... [more ▼]

The phase 3 program for strontium ranelate, a new oral agent in the treatment of women with postmenopausal osteoporosis, was aimed to assess the efficacy and safety of the daily oral dose of 2 g. This program was conducted in 12 countries, involved 75 centers, and was structured in 3 studies: FIRST (Fracture International Run-in for Strontium ranelate Trial), SOTI (Spinal Osteoporosis Therapeutic Intervention study) and TROPOS (TReatment Of Peripheral OSteoporosis). FIRST, a run-in open study, was designed to start the normalization of the calcium and vitamin D status of the patients, check all entry criteria, and ensure inclusion of a sufficient number of well-motivated patients in either one of the two therapeutic intervention protocols, SOTI or TROPOS: FIRST included 9,196 patients. SOTI and TROPOS were prospective, randomized, double-blind clinical trials comparing, in two parallel groups, the daily oral dose of 2 g of strontium ranelate with placebo, the patients of both groups receiving calcium and vitamin D according to their own deficiencies. The main objective of SOTI and TROPOS was to demonstrate a reduction in the incidence of postmenopausal women experiencing a new osteoporotic fracture (vertebral fracture in SOTI and nonvertebral fracture in TROPOS) over a 3-year treatment period, the total duration of the studies being 5 years. SOTI included 1,649 women with at least one osteoporotic vertebral fracture at inclusion and a lumbar BMD less than or equal to 0.840 g/cm(2). TROPOS included 5,091 women with a femoral neck BMD less than or equal to 0.600 g/cm(2). The phase 3 program for the clinical development of strontium ranelate in women with postmenopausal osteoporosis is a long-term program with the main statistical analysis after 3 years of treatment. Its aim is to demonstrate the effect of strontium ranelate on the axial and appendicular skeleton as well as its tolerability in osteoporotic patients with replete calcium and vitamin D stores. [less ▲]

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See detailBook review: Marine mammals biology and Conservation. Eds. PGH Evans and Raga J.A. Kluwer Academic/ Plenum Publishers
Das, Krishna ULg

in Journal of Marine Systems (2003), 43

Book review

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See detailComment je traite ... une dermatite seborrhéique.
Pierard, Claudine ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(2), 67-9

Seborrhoeic dermatitis results from a peculiar inflammatory reaction directed to yeasts of the genus Malassezia which are present at the skin surface. The current therapeutic strategies to control ... [more ▼]

Seborrhoeic dermatitis results from a peculiar inflammatory reaction directed to yeasts of the genus Malassezia which are present at the skin surface. The current therapeutic strategies to control episodes of the dermatitis target the yeasts, the host reaction or both. [less ▲]

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See detailRestart of lignification in micropropagated walnut shoots coincides with rooting induction
Bisbis, Badia; Kevers, Claire ULg; Crèvecoeur, Michèle et al

in Biologia Plantarum (2003), 47(1), 1-5

The lignin content of walnut shoots did not change during in vitro shoot Multiplication. Lignin content started to increase as soon as shoots were passed to a rooting medium with auxin. Exogenous auxin ... [more ▼]

The lignin content of walnut shoots did not change during in vitro shoot Multiplication. Lignin content started to increase as soon as shoots were passed to a rooting medium with auxin. Exogenous auxin (applied for rooting) Caused a transient elevation of the endogenous free indoleacetic acid (IAA) content with a Simultaneous decrease of peroxidase activity. These events typically marked the completion of the rooting inductive phase (before any visible histological event. that is before the cell divisions beginnin- the rootin- initiation phase). This meant that either the given exogenous auxin or the endogenous IAA has served as signal for the stimulation of lignification. Continued increase of lignification in the shoots required completion of root formation; this increase indeed was slown down when root emergence did not occur. It was further shown that lionification varied conversely to the content of the Soluble Phenol Content. itself apparently being related to the activity of phenylalanine ammonia-lyase activity. [less ▲]

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See detailMultiscale texture characterization of wastewater sludges dried in a convective rig
Léonard, Angélique ULg; Blacher, Silvia ULg; Pirard, René ULg et al

in Drying Technology (2003), 21(8), 1507-1526

Secondary sludges from two different wastewater treatment plants are conditioned and dewatered in the same way before drying in a lab-scale convective rig at the same operating conditions. Several ... [more ▼]

Secondary sludges from two different wastewater treatment plants are conditioned and dewatered in the same way before drying in a lab-scale convective rig at the same operating conditions. Several techniques are used to characterize the texture of the dried materials over a wide range of scales from nm up to mm. Texture and porosity of the dried products are studied by SEM imaging, nitrogen absorption isotherms (0.5 < d(p) < 50 nm), mercury porosimetry (7.5 nm < d(p) < 150 mum) and X-ray microtomography (spatial resolution= 41 mum). The image analysis of cross-sections reconstructed by microtomography also allows following shrinkage and textural evolution during drying. [less ▲]

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See detailChanging concepts in plant hormone action
Gaspar, Thomas ULg; Kevers, Claire ULg; Faivre-Rampant, Odile et al

in In Vitro Cellular & Developmental Biology-Plant (2003), 39(2, MAR-APR), 85-106

A plant hormone is not, in the classic animal sense, a chemical synthesized in one organ, transported to a second organ to exert a chemical action to control a physiological event. Any phytohormone can be ... [more ▼]

A plant hormone is not, in the classic animal sense, a chemical synthesized in one organ, transported to a second organ to exert a chemical action to control a physiological event. Any phytohormone can be synthesized everywhere and can influence different growth and development processes at different places. The concept of physiological activity under hormonal control cannot be dissociated from changes in concentrations at the site of action, from spatial differences and changes in the tissue's sensitivity to the compound, from its transport and its metabolism, from balances and interactions with the other phytohormones, or in their metabolic relationships, and in their signaling pathways as well. Secondary messengers are also involved. Hormonal involvement in physiological processes can appear through several distinct manifestations (as environmental sensors, homeostatic regulators and spatio-temporal synchronizers, resource allocators, biotime adjusters, etc.), dependent on or integrated with the primary biochemical pathways. The time has also passed for the hypothesized 'specific' developmental hormones, rhizocaline, caulocaline, and florigen: root, stem, and flower formation result from a sequential control of specific events at the right places through a coordinated control by electrical signals, the known phytohormones and nonspecific molecules of primary and secondary metabolism, and involve both cytoplasmic and apoplastic compartments. These contemporary views are examined in this review. [less ▲]

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See detailThe eyelids and metastatic breast carcinoma.
Claessens, Nadine; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(2), 181-2

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See detailAnimal welfare: The contribution of ethology
Vandenheede, Marc ULg

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 17-22

During the last fifty years, intensive husbandry has profoundly modified the animal living conditions, especially in pigs and poultry. At the same time, concerns about animal welfare were growing on ... [more ▼]

During the last fifty years, intensive husbandry has profoundly modified the animal living conditions, especially in pigs and poultry. At the same time, concerns about animal welfare were growing on. "Welfare " (" le bien-etre " in french) can be defined as a state of dynamic balance (homeostasy) between the animal and its environment (internal and external). The attempts of the animal to maintain or to adjust this balance may induce physical and mental sufferings, eventually harmful even on a health than on a performance point of view. Welfare of farm animals is assessed using 4 complementary and closely linked types of measures, i.e. performance, health, physiology and ethology. Ethological measurements involve a lot of advantages and are more and more utilised: study of adaptation abilities, behavioural disorders or animal motivation and preference. Ethology is thus considered as a very useful tool that can not be neglected, as shown by the important scientific work, notably in pigs and poultry. Research results have to constitute an essential prerequisite to the ethical reflection process regarding animal welfare, allowing to induce concrete and relevant political acts. [less ▲]

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See detailLa motivation du refus de prononcer une peine de travail
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailPreliminary observation of sperm storage in Adalia bipunctata (Coleoptera: Coccinellidae) : sperm size and number
Arnaud, Ludovic; Spinneux, Yves; Haubruge, Eric ULg

in Applied Entomology and Zoology (2003), 38

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See detailEvaluation of two commercial solid-phase microextraction fibres for the analysis of target aroma compounds in cooked beef meat
Machiels, D.; Istasse, Louis ULg

in Talanta (2003), 61(4), 529-537

The aroma profile of cooked beef meat has been investigated by solid-phase microextraction (SPME) combined with gas chromatography-mass spectrometry (GC-MS). Out of more than 200 volatile compounds, 36 ... [more ▼]

The aroma profile of cooked beef meat has been investigated by solid-phase microextraction (SPME) combined with gas chromatography-mass spectrometry (GC-MS). Out of more than 200 volatile compounds, 36 key odour-active compounds were selected for analysis. Several extraction times, desorption times, temperature conditions and fibre types were tested to achieve a fast and reproducible extraction, and a representative analysis of the aroma profile of cooked beef. Extraction conditions and fibre type significantly affected the majority of the target compounds. Divinylbenzene-carboxen-polydimethylsiloxane (DVB-CAR-PDMS) fibre presented a better reproducibility at all extraction times and extracted more efficiently the less volatile compounds than the carboxen-polydimethylsiloxane (CAR-PDMS) fibre. The high molecular weight compounds seemed to achieve faster the equilibrium between the headspace and DVB-CAR-PDMS fibre. The use of SPME was shown to be a simple, sensitive, selective, representative, fast, and low-cost method for the evaluation of key odour-active compounds in cooked beef meat, even if further research on quantitative analysis of volatiles using SPME on solid samples has to be done. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailApport à la connaisance du genre Rhizophagus Herbst, 1793 (Coleoptera: Clavicornia Monotomidae) en région wallonne (Belgique)
Thieren, Yves; Fagot, Jean ULg; Lhoir, Jonathan et al

in Notes Fauniques de Gembloux (2003), 50

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations ... [more ▼]

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations between species and trapping methods and on the species activity during the six months trapping. Waiting for an exhaustive revision of the genera, a primary point is made on the Rhizophagus in Belgium and a prime list is given with a lot of ethological considerations. [less ▲]

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See detailLe cas clinique du mois. Masse médiastinale antérieure chez une patiente acromégale.
Laret, Vinciane ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Revue Médicale de Liège (2003), 58(12), 724-728

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the ... [more ▼]

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the first diagnostic step consists of finding the etiology of the disease in order to use adequate treatment. This can be complicated by the fact that acromegaly can be associated with other tumors (for instance in MEN-1 disease and Carney Complex) and because chronic GH hypersecretion can stimulate tumor overgrowth and perhaps tumor formation. We describe the case of a 44-year-old acromegalic woman with an anterior mediastinal mass. We present the different diagnoses and a review of the literature. [less ▲]

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See detailLipid storage metabolism is limited by the prevailing low oxygen concentrations within developing seeds of oilseed rape.
Vigeolas, Hélène ULg; van Dongen, Joost T; Waldeck, Peter et al

in Plant Physiology (2003), 133(4), 2048-60

The aim of this study was to investigate whether endogenous restrictions in oxygen supply are limiting for storage metabolism in developing oilseed rape (Brassica napus) seeds. Siliques were studied 30 d ... [more ▼]

The aim of this study was to investigate whether endogenous restrictions in oxygen supply are limiting for storage metabolism in developing oilseed rape (Brassica napus) seeds. Siliques were studied 30 d after flowering, when rapid lipid accumulation is occurring in the seeds. (a). By using microsensors, oxygen concentrations were measured within seeds and in the silique space between seeds. At ambient external oxygen (21% [v/v]) in the light, oxygen fell to 17% (v/v) between and 0.8% (v/v) within seeds. A step-wise reduction of the external oxygen concentration led within 2 h to a further decrease of internal oxygen concentrations, and a step-wise increase of the external oxygen concentration up to 60% (v/v) resulted in an increase in internal oxygen that rose to 30% (v/v) between and 8% (v/v) within seeds. (b). The increase in oxygen levels in the seeds was accompanied by a progressive increase in the levels of ATP, UTP, and the ATP to ADP and UTP to UDP ratios over the entire range from 0% to 60% (v/v) external oxygen. (c). To investigate metabolic fluxes in planta, 14C-sucrose was injected into seeds, which remained otherwise intact within their siliques. The increase in oxygen in the seeds was accompanied by a progressive increase in the rate of lipid (including triacylglycerol), protein and cell wall synthesis, and an increase in glycolytic flux over a range from sub- to superambient oxygen concentrations. In contrast to lipid synthesis, starch synthesis was not significantly increased at superambient oxygen levels. The levels of fermentation products such as lactate and glycerol-3P increased only at very low (0%-4% [v/v]) external oxygen concentrations. (d). When 14C-acetate or 14C-acetyl-coenzyme A (CoA) was injected into seeds, label incorporation into triacylglycerol progressively increased over the whole range of external oxygen concentrations from 0% to 60% (v/v). (e). Stimulation of lipid synthesis was accompanied by an increase in sugar levels and a decrease in the levels of hexose-phosphates and acetyl-CoA, indicating sucrose unloading and the use of acetyl-CoA as possible regulatory sites. (f). Increased lipid synthesis was also accompanied by an increase in the maximal activities of invertase and diacylglycerol acyltransferase. (g). The developmental shift from starch to lipid storage between 15 and 45 d after flowering was accompanied by an increase in the seed energy state. (h). The results show that at ambient oxygen levels, the oxygen supply is strongly limiting for energy metabolism and biosynthetic fluxes in growing rape seeds, affecting lipid synthesis more strongly than starch synthesis. The underlying mechanisms and implications for strategies to increase yield and storage product composition in oilseed crops are discussed. [less ▲]

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See detailLifting, Superadditivity, Mixed Integer Rounding and Single Node Flow Sets Revisited
Louveaux, Quentin ULg; Wolsey, Laurence A.

in 4OR : Quarterly Journal of the Belgian, French and Italian Operations Research Societies (2003), 1

In this survey we attempt to give a unified presentation of a variety of results on the lifting of valid inequalities, as well as a standard procedure combining mixed integer rounding with lifting for the ... [more ▼]

In this survey we attempt to give a unified presentation of a variety of results on the lifting of valid inequalities, as well as a standard procedure combining mixed integer rounding with lifting for the development of strong valid inequalities for knapsack and single node flow sets. Our hope is that the latter can be used in practice to generate cutting planes for mixed integer programs. The survey contains essentially two parts. In the first we present lifting in a very general way, empha- sizing superadditive lifting which allows one to lift simultaneously different sets of variables. In the second, our procedure for generating strong valid inequalities consists of reduction to a knapsack set with a single continuous variable, construc- tion of a mixed integer rounding inequality, and superadditive lifting. It is applied to several generalizations of the 0-1 single node flow set. [less ▲]

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See detailUne dermatite atopique sensible à un antifongique IBE.
Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2003), 75

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See detailPour améliorer l'apprentissage d'une langue moderne à l'école primaire
Blondin, Christiane ULg; Straeten, M.

in Point sur la Recherche en Education (Le) (2003), 27

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See detailComedolysis by a lipohydroxyacid formulation in acne-prone subjects.
Uhoda, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in European Journal of Dermatology (2003), 13(1), 65-8

Post-summertime exacerbation of acne is not a rare event. This study was conducted to assess the preventive effect of a proprietary formulation containing 2-hydroxy-5-octanoyl benzoic acid on this ... [more ▼]

Post-summertime exacerbation of acne is not a rare event. This study was conducted to assess the preventive effect of a proprietary formulation containing 2-hydroxy-5-octanoyl benzoic acid on this environmental related disease. This compound is commonly called beta-lipohydroxyacid (LHA). Among a randomized group of 14 acne-prone women, 12 who developed cornified follicular plugs the end of summertime were treated by the LHA formulation twice daily for 2 weeks. Ten of 14 other women who presented the same skin condition remained untreated as controls. The comedolytic effect was assessed using non-invasive ultraviolet-light video recording combined with computerized image analysis. The cornified follicular plugs were progressively cleared in 10/12 LHA-treated women and in 3/10 untreated volunteers. Analytical assessments showed a significant decrease in both the number and total size of microcomedones in the LHA-treated women. By contrast, no quantitative change was disclosed in the untreated group. It is concluded that the tested LHA formulation exerts comedolytic properties that might help in preventing post-summertime acne exacerbations. [less ▲]

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See detailAn Improved Method of Photometric Mode Identification: Applications to Slowly Pulsating B, beta Cephei, delta Scuti and gamma Doradus Stars
Dupret, Marc-Antoine ULg; Scuflaire, Richard ULg; Noels-Grötsch, Arlette ULg et al

in Astrophysics & Space Science (2003), 284

We present an improved version of the method of photometric mode identification based upon the inclusion of non-adiabatic eigenfunctions determined in the stellar atmosphere, according to the formalism ... [more ▼]

We present an improved version of the method of photometric mode identification based upon the inclusion of non-adiabatic eigenfunctions determined in the stellar atmosphere, according to the formalism recently proposed by Dupret et al. (2002). We apply our method to beta Cephei, Slowly Pulsating B, delta Scuti and gamma Doradus stars. Besides identifying the degree l of the pulsating stars, our method is also a tool for improving the knowledge of stellar interiors and atmospheres, by imposing constraints on the metallicity for beta Cephei and SPBs, the characteristics of the superficial convection zone for delta Scuti and gamma Doradus stars and the limb-darkening law. [less ▲]

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See detailDépart à la retraite: une perspective internationale
Jousten, Alain ULg

in Revue Française d'Economie (2003), XVIII

Des différences internationales importantes persistent quant au taux d'activité des travailleurs âgés et à l'âge du départ à la retraite. Tandis que certains pays d'Europe continentale sont caractérisés ... [more ▼]

Des différences internationales importantes persistent quant au taux d'activité des travailleurs âgés et à l'âge du départ à la retraite. Tandis que certains pays d'Europe continentale sont caractérisés par des taux d'activités relativement faibles, d'autres pays développés ne connaissent pas cette tendance. Nous illustrons le rôle important joué par les décisions individuelles dans le contexte du départ à la retraite. [less ▲]

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See detailLa géographie humaine et ses revues « internationales » : globalisation ou fragmentation
Schmitz, Serge ULg

in Annales de Géographie (2003), 112(632), 402-411

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See detailSoluble transferrin receptor for the evaluation of erythropoiesis and iron status.
Beguin, Yves ULg

in Clinica Chimica Acta (2003), 329(1-2), 9-22

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR ... [more ▼]

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR (sTfR) has been identified in animal and human serum. Soluble TfR is a truncated monomer of tissue receptor, lacking its first 100 amino acids, which circulates in the form of a complex of transferrin and its receptor. The erythroblasts rather than reticulocytes are the main source of serum sTfR. Serum sTfR levels average 5.0+/-1.0 mg/l in normal subjects but the various commercial assays give disparate values because of the lack of an international standard. The most important determinant of sTfR levels appears to be marrow erythropoietic activity which can cause variations up to 8 times below and up to 20 times above average normal values. Soluble TfR levels are decreased in situations characterized by diminished erythropoietic activity, and are increased when erythropoiesis is stimulated by hemolysis or ineffective erythropoiesis. Measurements of sTfR are very helpful to investigate the pathophysiology of anemia, quantitatively evaluating the absolute rate of erythropoiesis and the adequacy of marrow proliferative capacity for any given degree of anemia, and to monitor the erythropoietic response to various forms of therapy, in particular allowing to predict response early when changes in hemoglobin are not yet apparent. Iron status also influences sTfR levels, which are considerably elevated in iron deficiency anemia but remain normal in the anemia of inflammation, and thus may be of considerable help in the differential diagnosis of microcytic anemia. This is particularly useful to identify concomitant iron deficiency in a patient with inflammation because ferritin values are then generally normal. Elevated sTfR levels are also the characteristic feature of functional iron deficiency, a situation defined by tissue iron deficiency despite adequate iron stores. The sTfR/ferritin ratio can thus describe iron availability over a wide range of iron stores. With the exception of chronic lymphocytic leukemia (CLL) and high-grade non-Hodgkin's lymphoma and possibly hepatocellular carcinoma, sTfR levels are not increased in patients with malignancies. We conclude that soluble TfR represents a valuable quantitative assay of marrow erythropoietic activity as well as a marker of tissue iron deficiency. [less ▲]

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See detailMultiple mechanisms control brain aromatase activity at the genomic and non-genomic level
Balthazart, Jacques ULg; Baillien, Michelle; Charlier, Thierry ULg et al

in Journal of Steroid Biochemistry & Molecular Biology (2003), 86

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms ... [more ▼]

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms. We review here these two types of control mechanisms and their potential contribution to various aspects of brain physiology in quail. High levels of aromatase mRNA, protein and activity (AA) are present in the preoptic area of this species where the transcription of aromatase is controlled mainly by steroids. Estrogens acting in synergy with androgens play a key role in this control and both androgen and estrogen receptors (ER; alpha and beta subtypes) are present in the preoptic area even if they are not necessarily co-localized in the same cells as aromatase. Steroids have more pronounced effects on aromatase transcription in males than in females and this sex difference could be caused, in part, by a sexually differentiated expression of the steroid receptor coactivator 1 in this area. The changes in aromatase concentration presumably control seasonal variations as well as sex differences in brain estrogen production. Aromatase activity in hypothalamic homogenates is also rapidly (within minutes) down-regulated by exposure to conditions that enhance protein phosphorylation such as the presence of high concentrations of calcium, magnesium and ATP. Similarly, pharmacological manipulations such as treatment with thapsigargin or stimulation of various neurotransmitter receptors (alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid (AMPA), kainate, and N-methyl-d-aspartate (NMDA)) leading to enhanced intracellular calcium concentrations depress within minutes the aromatase activity measured in quail preoptic explants. The effects of receptor stimulation are presumably direct: electrophysiological data confirm the presence of these receptors in the membrane of aromatase-expressing cells. Inhibitors of protein kinases interfere with these processes andWestern blotting experiments on brain aromatase purified by immunoprecipitation confirm that the phosphorylations regulating aromatase activity directly affect the enzyme rather than another regulatory protein. Accordingly, several phosphorylation consensus sites are present on the deduced amino acid sequence of the recently cloned quail aromatase. Fast changes in the local availability of estrogens in the brain can thus be caused by aromatase phosphorylation so that estrogen could rapidly regulate neuronal physiology and behavior. The rapid as well as slower processes of local estrogen production in the brain thus match well with the genomic and non-genomic actions of steroids in the brain. These two processes potentially provide sufficient temporal variation in the bio-availability of estrogens to support the entire range of established effects for this steroid. [less ▲]

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See detailInteret des expectorations induites dans l'exploration de l'asthme.
Louis, Renaud ULg; Bettiol, Jane; Cataldo, Didier ULg et al

in Revue des Maladies Respiratoires (2003), 20(2 Pt 1), 215-23

INTRODUCTION: The technique of induced expectoration generates sputum by the inhalation of hypertonic saline. On account of its non-invasive character, its simplicity, its relative harmlessness, its cost ... [more ▼]

INTRODUCTION: The technique of induced expectoration generates sputum by the inhalation of hypertonic saline. On account of its non-invasive character, its simplicity, its relative harmlessness, its cost effectiveness and its reproducibility this technique, that appeared in the early 1990's, has rapidly established itself as the technique of choice in the investigation of bronchial inflammation in asthma. STATE OF THE ART: We present the results of our studies that have contributed to the validation of the technique at the methodological level and to the exploitation of the cellular contents as much as the fluid phase of the expectorations in characterising bronchial inflammation in asthmatics. Our results confirm an infiltration of the airways of asthmatics with eosinophils that appears to be proportional to the severity of the illness. We evaluate the effect of inhaled steroids and of theophylline on sputum eosinophilia and bronchial reactivity and discuss the role of eosinophils on bronchial hyperreactivity. Finally we discuss the use of induced expectoration in clinical practice in asthma. PERSPECTIVES: The analysis of induced sputum could well become a valuable tool in the clinical evaluation and monitoring of asthma in the same way as symptoms and abnormalities of lung function. CONCLUSIONS: Induced expectoration has certainly contributed to the understanding of the cellular and molecular mechanisms of asthma as well as the role of bronchial inflammation in the clinical manifestations of the disease. [less ▲]

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See detailAssociation of milk traits with SSCP polymorphisms at the growth hormone gene in the serrana goat
Marques, P. X.; Pereira, M.; Marques, M. R. et al

in Small Ruminant Research (2003), 50

The five exons and the 5' and 3'-untranslated regions (5'-UTR and 3'-UTR) of the oGH gene were screened for mutations using PCR-single strand conformation polymorphism (PCR-SSCP) procedures in 523 Serra ... [more ▼]

The five exons and the 5' and 3'-untranslated regions (5'-UTR and 3'-UTR) of the oGH gene were screened for mutations using PCR-single strand conformation polymorphism (PCR-SSCP) procedures in 523 Serra da Estrela ewes and were found to be highly polymorphic. The region extending across and between the GH2-N and GH2-Z copies was sequenced allowing the design of primers for the specific PCR amplification of each copy. These were cloned and sequenced in 20 animals representative of all SSCP patterns. The corresponding genotypes were established for each copy following nucleotide sequencing of SSCP alleles. Twenty-four polymorphic sites were found at the GH2-N (or GH1) and fourteen at the GH2-Z copies. Eight amino acid substitutions were predicted at the GH2-N and six at the GH2-Z copies. Milk yield adjusted to 150 lactation days was analysed for the genotype of each oGH gene copy taken separately or together (associated genotypes) by restricted maximum likelihood (REML) through a univariate best linear unbiased prediction (BLUP) animal model with repeated measures. Significant associations between genotypes and milk yield were observed. Within GH2-N genotypes there was a milk yield differential of 21.4+/-0.2 l/150 d between the most (N7) and the least (N5) productive ones. Within GH2-Z genotypes there was a differential of 21.6+/-0.2 l/150 d between the most (Z8) and the least (Z1) productive ones. The effect of associated GH2-N and GH2-Z genotypes revealed a differential of 39.6+/-0.3 l/150 d between the most (N1+Z7) and the least (N3+Z2) productive associated genotypes. The results show that GH2-N and GH2-Z genotypes significantly affect milk yield in Serra da Estrela ewes. Moreover, the apparent joint effect of GH2-N and GH2-Z genotype could improve milk yield in 25% as compared with the mean milk production of the analysed population. [less ▲]

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