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See detailNon-uniform adaptive vertical grids in one-dimensional numerical ocean models
Burchard, Hans; Beckers, Jean-Marie ULiege

in Ocean Modelling (2004), 6(1), 51-81

It is demonstrated in this paper how the concept of general vertical coordinates can be exploited for constructing adaptive grids in primitive equation ocean models. The term adaptive is used here in the ... [more ▼]

It is demonstrated in this paper how the concept of general vertical coordinates can be exploited for constructing adaptive grids in primitive equation ocean models. The term adaptive is used here in the sense of coordinate iso-surfaces which follow certain internal structures of the flow in such a way that higher vertical resolution is obtained in locations where vertical gradients are large. The internal structures considered here are shear and stratification. In this paper, one-dimensional models are applied in order to demonstrate the ability of such grid adaptation methods to follow internal structures even in flow situations dominated by vertical mixing processes. Here, a variational approach is considered for the generation of grids which results in a diffusion equation for the vertical coordinate. The method is tested for five different idealised and realistic scenarios with the result that the discretisation error can be significantly reduced in comparison to equidistant Cartesian grids. Some recommendations for extending these methods for three-dimensional models are given at the end of this paper. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailModelling and analysis of a MEMS approach to dc voltage step-up conversion
Haas, C. H.; Kraft, Michaël ULiege

in Journal of Micromechanics and Microengineering (2004), 14(9), 114-122

This paper studies the principle of a novel voltage step-up converter based on a micromachined variable parallel-plate capacitor in combination with an electrostatic actuator. Electrical equivalent ... [more ▼]

This paper studies the principle of a novel voltage step-up converter based on a micromachined variable parallel-plate capacitor in combination with an electrostatic actuator. Electrical equivalent circuit and system-level SIMULINK models have been developed. Based on these models, an analysis of design parameters and expected device performance has been performed to serve as a starting point for a prototype implementation. Possible areas of application are self-powered, stand-alone sensing systems, aerospace applications and any kind of electrostatic or piezoelectric MEMS devices in general. [less ▲]

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See detailThe contribution of uncoupling protein and ATP synthase to state 3 respiration in Acanthamoeba castellanii mitochondria.
Jarmuszkiewicz, W.; Czarna, M.; Sluse-Goffart, C. et al

in Acta Biochimica Polonica. Polish. (2004), 51

Mitochondria of the amoeba Acanthamoeba castellanii possess a free fatty acid-activated uncoupling protein (AcUCP) that mediates proton re-uptake driven by the mitochondrial proton electrochemical ... [more ▼]

Mitochondria of the amoeba Acanthamoeba castellanii possess a free fatty acid-activated uncoupling protein (AcUCP) that mediates proton re-uptake driven by the mitochondrial proton electrochemical gradient. We show that AcUCP activity diverts energy from ATP synthesis during state 3 mitochondrial respiration in a fatty acid-dependent way. The efficiency of AcUCP in mitochondrial uncoupling increases when the state 3 respiratory rate decreases as the AcUCP contribution is constant at a given linoleic acid concentration while the ATP synthase contribution decreases with respiratory rate. Respiration sustained by this energy-dissipating process remains constant at a given linoleic acid concentration until more than 60% inhibition of state 3 respiration by n-butyl malonate is achieved. The present study supports the validity of the ADP/O method to determine the actual contributions of AcUCP (activated with various linoleic acid concentrations) and ATP synthase in state 3 respiration of A.castellanii mitochondria fully depleted of free fatty acid-activated and describes how the two contributions vary when the rate of succinate dehydrogenase is decreased by succinate uptake limitation [less ▲]

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See detailLes défis de la revalidation d'une dysfonction érectile depuis l'arrivée des traitements actifs par voie orale
Andrianne, Robert ULiege; Debois, Christine ULiege; Mormont, Christian ULiege et al

in Références en Gynécologie Obstétrique (2004), 10

Now, it is relatively easy to restore normal erections in many patients thanks to active oral drugs. However, full success is a complicated process, which is not limited to mechanical response to ... [more ▼]

Now, it is relatively easy to restore normal erections in many patients thanks to active oral drugs. However, full success is a complicated process, which is not limited to mechanical response to treatment. Treatment discontinuation rates are much higher than expected, given efficacy of these drugs, because other factors such as partner relationship and couple well being are implicated. [less ▲]

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See detailHyperhidrose palmaire et axillaire.
Uhoda, Emmanuelle ULiege; Pierard, Gérald ULiege

in Dermatologie Actualité (2004), 84

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See detailElectrical machine analysis considering field-circuit-movement and skewing effects
de Oliveira, Ana Margarida; Antunes, R.; Kuo-Peng, Patrick et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(4), 1080-1091

This paper presents a method to analyse electrical machines considering simultaneously the electromagnetic field, electric circuit, control loop, movement and skewing effects. The major contribution of ... [more ▼]

This paper presents a method to analyse electrical machines considering simultaneously the electromagnetic field, electric circuit, control loop, movement and skewing effects. The major contribution of this work leans on its generality, i.e. it can be applied to electrical machines connected to static converters submitted to any control laws, avoiding an a priori analysis. Simulation results of a three-phase Brushless AC (BLAC) motor fed by a PWM converter is presented as well as a comparison of simulation and experimental results obtained using a two-phase-on converter were also presented. [less ▲]

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See detailA family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects
Lange, C.; Van Steen, Kristel ULiege; Andrew, T. et al

in Statistical Applications in Genetics and Molecular Biology (2004), 3(1), 17

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See detailCette île est mienne... et tu me l'as prise: Shakespeare au XXe siècle
Maes-Jelinek, Hena ULiege

in Bulletin de la Classe des Lettres et des Sciences Morales et Politiques (2004), 15(1-6), 23-41

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See detailComment j'explore... une perte de cheveux chez un patient cancéreux.
Pierard, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2004), 59(9), 525-9

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can ... [more ▼]

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can be responsible for these disturbing events. The alopecia is transient or permanent according to its origin. Diverse diagnostic and prognostic methods are available for assessing alopecias. The trichogram is a rewarding one. [less ▲]

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See detailCardiac tamponade and pulmonary compression due to volvulus of oesophageal coloplasty
Canivet, Jean-Luc ULiege; Piret, Sonia ULiege; Hick, Gaëtane ULiege et al

in Acta Anaesthesiologica Belgica (2004), 55(2), 125-127

We describe an unusual case of cardiac tamponade and pulmonary compression due to acute volvulus of colon interposition occuring late after oesophagectomy. Clinical signs were suggestive of cardiac ... [more ▼]

We describe an unusual case of cardiac tamponade and pulmonary compression due to acute volvulus of colon interposition occuring late after oesophagectomy. Clinical signs were suggestive of cardiac tamponade but there was no evidence of pericardial effusion by transthoracic echocardiography. Thoracic-CT provided the diagnostic clue in revealing the extrapericardial nature (a major dilatation of the colonic transplant) of the tamponade. This diagnosis should be considered in case of acute cardiopulmonary distress occuring early or late after oesophagectomy. [less ▲]

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See detailEndocrine profiles, haematology and pregnancy outcomes of late pregnant Holstein dairy heifers sired by bulls giving a high or low incidence of stillbirth
Kornmatitsuk, B.; Dahl, E.; Ropstad, E. et al

in Acta Veterinaria Scandinavica (2004), 45(1-2), 47-68

The high incidence of stillbirth in Swedish Holstein heifers has increased continuously during the last 15 years to an average of 11% today. The pathological reasons behind the increased incidence of ... [more ▼]

The high incidence of stillbirth in Swedish Holstein heifers has increased continuously during the last 15 years to an average of 11% today. The pathological reasons behind the increased incidence of stillbirth are unknown. The present experiment was undertaken to investigate possible causes of stillbirth and to study possible physiological markers for predicting stillbirth. Twenty Swedish Holstein dairy heifers sired by bulls with breeding values for a high risk of stillbirth (n = 12) (experimental group) and a low risk of stillbirth (n = 8) (control group, group B) were selected based on information in the Swedish A1-data base. The experimental group consisted of 2 subgroups of heifers (groups A1 and A2) inseminated with 2 different bulls with 3.5% and 9% higher stillbirth rates than the average, and the control group consisted of heifers pregnant with 5 different bulls with 0%-6% lower stillbirth rates than the average. The bull used for group A1 had also calving difficulties due to large calves as compared to the bull in group A2 showing no calving difficulties. The heifers were supervised from 6-7 months of pregnancy up to birth, and the pregnancies and parturitions were compared between groups regarding hormonal levels, haematology, placental characteristics and calf viability. In group A1, 1 stillborn, 1 weak and 4 normal calves were recorded. In group A2, 2 stillborn and 4 normal calves were registered. All animals in the control group gave birth to a normal living calf without any assistance. The weak calf showed deviating profiles of body temperature, saturated oxygen and heart rates, compared with the normal living calves. No differences of the placentome thickness, measured in vivo by Ultrasonography were seen between the groups. The number of leukocytes and differential cell counts in groups A1 and A2 followed the profiles found in the control group. In group A1, a slight decrease of oestrone sulphate (E1S04) levels was found in the animal delivering a stillborn calf from the first 24-h blood sampling at 6 weeks to the second at 3 weeks prior to delivery, while the levels of E1S04 at both periods in the animal delivering a weak calf followed the profile in animals delivering a normal living calf. During late pregnancy and at the time of parturition, the levels of E1SO4 and PAGs in animals delivering a stillborn or weak calf (from group A1) followed the normal profiles found in animals delivering a normal living calf. In group A2, low levels of E1SO4 and pregnancy associated glycoproteins (PAGs) over 24 h at both 3 and 6 weeks prior to parturition (<1.5 nmol/L) were recorded in animals delivering a stillborn calf During late pregnancy and parturition, the levels of E1SO4 and PAGs were slightly lower during 30-50 days prior to delivery and increased with a lower magnitude at the time of parturition. In conclusion, our results indicate that the aetiology behind stillbirth varies depending on the AI-bulls used and is associated with dystocia or low viability of the calves. Deviating profiles of oestrone sulphate (E1SO4) and pregnancy associated glycoproteins (PAGs) in animals delivering a stillborn calf not caused by dystocia were observed, suggesting placental dysfunction as a possible factor. The finding suggests that the analyses of E1SO4 and PAGs could be used for monitoring foetal well-being in animals with a high risk of stillbirth at term. [less ▲]

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See detailUltralow silicon substrate noise crosstalk using metal Faraday cages in an SOI technology
Stefanou, Stefanos; Hamel, John Stan; Baine, Paul et al

in IEEE Transactions on Electron Devices (2004), 51(3), 486--491

Ultralow substrate crosstalk is demonstrated using a novel metal Faraday cage isolation scheme in silicon-on-insulator technology. Over ten times reduction in crosstalk is demonstrated up to 10 GHz ... [more ▼]

Ultralow substrate crosstalk is demonstrated using a novel metal Faraday cage isolation scheme in silicon-on-insulator technology. Over ten times reduction in crosstalk is demonstrated up to 10 GHz, compared to previously reported substrate crosstalk suppression technologies. [less ▲]

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See detailThe contribution of 211 particles to the mechanical reinforcement mechanism of 123 superconducting single domains
Mathieu, Jean-Philippe; Cano, I. G.; Koutzarova, T. et al

in Superconductor Science and Technology (2004), 17(1), 169-174

Hardness and fracture toughness of Dy-123 single domains were studied by Vickers in micro-indentation. A significant anisotropy of the mechanical properties was observed. Hardness tests give higher values ... [more ▼]

Hardness and fracture toughness of Dy-123 single domains were studied by Vickers in micro-indentation. A significant anisotropy of the mechanical properties was observed. Hardness tests give higher values when performed in (001) planes rather than in planes parallel to the c-axis. Moreover, the cracks pattern around the indentation follows preferential orientation in planes parallel to the c-axis whereas a classical 'four-cracks' pattern is observed in the (001) planes. It has been possible to show the crucial role played by the 211 particles in the deviating mechanism of cracks and the relevance of the high homogeneity of 211-particle distribution in the material. [less ▲]

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See detailComparative titration of ginsenosides by different techniques in commercial ginseng products and callus cultures
Kevers, Claire ULiege; Jacques, Philippe ULiege; Gaspar, Thomas ULiege et al

in Journal of Chromatographic Science (2004), 42(10, Nov-Dec), 554-558

The ginsenoside content of different ginseng species (Panax ginseng, P. quinquefolium, and P. vietnamensis) from different sources (roots from field-grown plants or from in vitro cultures, cells from ... [more ▼]

The ginsenoside content of different ginseng species (Panax ginseng, P. quinquefolium, and P. vietnamensis) from different sources (roots from field-grown plants or from in vitro cultures, cells from solid calluses or from liquid cultures, commercial powders, and suspensions) is evaluated by means of a new high-performance thin-layer chromatography (HPTLC) technique combining an automatic TLC sampler and scanner. The results are compared with those obtained through more classical gross spectrometric and high-performance liquid chromatography (HPLC) techniques. HPTLC and HPLC allow the separation and estimation of the different ginsenosides. For this, HPTLC is faster and simpler than HPLC. Both techniques determine less amounts of ginsenosides than spectrophotometry, which displays overestimated values caused by light absorption by contaminating osides. In vitro cultured cells and roots contain the same ginsenosides as those produced by their mother plants, although at quite lower levels. The culture media also accumulates ginsenosides. [less ▲]

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See detailFinite element modelling of stacked thin regions with non-zero global currents
Dular, Patrick ULiege; Gyselinck, Johan; Zeidan, Tarek et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(3), 707-714

Develops a method to take the eddy currents in stacked thin regions, in particular lamination stacks, into account with the finite element method using the 3D magnetic vector potential magnetodynamic ... [more ▼]

Develops a method to take the eddy currents in stacked thin regions, in particular lamination stacks, into account with the finite element method using the 3D magnetic vector potential magnetodynamic formulation. It consists in converting the stacked laminations into continuums with which terms are associated for considering the eddy current loops produced by both parallel and perpendicular fluxes. Non-zero global currents can be considered in the laminations, in particular for studying the effect of imperfect insulation between their ends. The method is based on an analytical expression of eddy currents and is adapted to a wide frequency range. [less ▲]

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See detailWhole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs
Halloy, D.; Kirschvink, Nathalie; Vincke, G. et al

in Veterinary Journal (2004), 168

The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the ... [more ▼]

The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the intensity of the pulmonary response to endotoxins. Penh was firstly recorded in non-sedated freeiy moving piglets exposed (1) to a nebulized acetylchoiine (Ach) pre-treated or not with cienbuterol, or (2) to endotoxin challenge. To measure Penh simultaneously with total pulmonary resistance (RL), dynamic compliance (cd1) and intrapleural pressure changes (MaxPpl), an oesophageal balloon catheter technique was used and the piglets were anaesthetised. The recordings were performed during (1) an intravenous metacholine (Mch) challenge and (2) in endotoxin-exposed animais. In freely moving animais, Ach induced a significant dose-dependent increase in Penh, which was significantly blocked by clenbuterol. Endotoxin instillation aiso resulted in a significant rise in Penh while the corresponding response measured under anaesthesia was signiflcantly and positively correlated with RL and MaxzPpi. Similar results were obtained during Mch challenge but the Penh was negatively correlated with Cd. We conclude that Penh could be used in freely moving piglets as a screening index for airway reactivity and pulmonary functional changes in cholinergic and endotoxin challenges [less ▲]

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See detailEarly neurophysiological diagnosis of true neurogenic « thoracic outlet syndrome » (TOS)
HUA, MT; DUBUISSON, Annie ULiege; Zeevaert, Bernard et al

in Journal of Neurology (2004)

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See detailGenome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis
Vermeire, S.; Rutgeerts, P.; Van Steen, Kristel ULiege et al

in Gut (2004), 53(7), 980-986

Background and aims: Genome wide scans in inflammatory bowel disease (IBD) have indicated various susceptibility regions with replication of 16cen (IBD1), 12q (IBD2), 6p (IBD3), 14q11 (IBD4), and 3p21. As ... [more ▼]

Background and aims: Genome wide scans in inflammatory bowel disease (IBD) have indicated various susceptibility regions with replication of 16cen (IBD1), 12q (IBD2), 6p (IBD3), 14q11 (IBD4), and 3p21. As no linkage was previously found on IBD regions 3, 7, 12, and 16 in Flemish IBD families, a genome wide scan was performed to detect other susceptibility regions in this population. Methods: A cohort of 149 IBD affected relative pairs, all recruited from the Northern Flemish part of Belgium, were genotyped using microsatellite markers at 12 cM intervals, and analysed by Genehunter non-parametric linkage software. All families were further genotyped for the three main Crohn's disease associated variants in the NOD2/CARD15 gene. Results: Nominal evidence for linkage was observed on chromosomes 1 (D1S197: multipoint nonparametric linkage (NPL) score 2.57, p = 0.004; and at D1S305-D1S252: NPL 2.97, p = 0.001), 4q (D4S406: NPL 1.95, p = 0.03), 6q16 (D6S314: NPL 2.44, p = 0.007), 10p12 (D10S197: NPL 2.05, p = 0.02), 11q22 (D11S35-D11S927: NPL 1.95, p = 0.02) 14q11-12 (D14S80: NPL 2.41, p = 0.008), 20p12 (D20S192: NPL 2.7, p = 0.003), and Xq (DXS990: NPL 1.70, p = 0.04). A total of 51.4% of patients carried at least one NOD2/CARD15 variant. Furthermore, epistasis was observed between susceptibility regions 6q/10p and 20p/10p. Conclusion: Genome scanning in a Flemish IBD population found nominal evidence for linkage on 1p, 4q, 10p12, and 14q11, overlapping with other genome scan results, with linkage on 14q11-12 supporting the IBD4 locus. The results further show that epistasis is contributing to the complex model of IBD and indicate that population heterogeneity is not to be underestimated. Finally, NOD2/CARD15 is clearly implicated in the Flemish IBD population. [less ▲]

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See detailIncorporation of a Jiles-Atherton vector hysteresis model in 2D FE magnetic field computations - Application of the Newton-Raphson method
Gyselinck, Johan; Dular, Patrick ULiege; Sadowski, Nelson et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(3), 685-693

his paper deals with the incorporation of a vector hysteresis model in 2D finite-element (FE) magnetic field calculations. A previously proposed vector extension of the well-known scalar Jiles-Atherton ... [more ▼]

his paper deals with the incorporation of a vector hysteresis model in 2D finite-element (FE) magnetic field calculations. A previously proposed vector extension of the well-known scalar Jiles-Atherton model is considered The vectorised hysteresis model is shown to have the same advantages as the scalar one: a limited number of parameters (which have the same value in both models) and ease of implementation The classical magnetic vector potential FE formulation is adopted Particular attention is paid to the resolution of the nonlinear equations by means of the Newton-Raphson method It is shown that the application of the latter method naturally leads to the use of the differential reluctivity tensor, i.e. the derivative of the magnetic field vector with respect to the magnetic induction vector. This second rank tensor can be straightforwardly calculated for the considered hysteresis model. By way of example, the vector Jiles-Atherton is applied to two simple 2D FE models exhibiting rotational flux. The excellent convergence of the Newton-Raphson method is demonstrated. [less ▲]

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See detailL’héritage et l’archive
Badir, Sémir ULiege; Baetens, Jan

in Protée (2004), 32(2), 5-8

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See detailEntreprendre au féminin : une réalité multiple et des attentes différenciées
Cornet, Annie ULiege; Constantinidis, Christina ULiege

in Revue Française de Gestion (2004), 30(151), 191-204

Les femmes optent de plus en plus souvent pour le statut d’indépendante et, trop rarement encore, pour le statut de « chef d’entreprise ». Cet article cherche à comprendre les facteurs qui semblent guider ... [more ▼]

Les femmes optent de plus en plus souvent pour le statut d’indépendante et, trop rarement encore, pour le statut de « chef d’entreprise ». Cet article cherche à comprendre les facteurs qui semblent guider leur choix, le type d’activités vers lesquelles elles s’orientent, les difficultés qu’elles rencontrent ainsi que leurs succès et les stratégies mises en œuvre pour réussir leur projet. Cet article est fondé sur une recherche quantitative et qualitative qui permet de montrer que le projet entrepreneurial des femmes a certes des similarités avec celui des hommes mais certains choix et stratégies restent marqués par des rapports sociaux de genre. [less ▲]

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See detailCoping with mild inflammatory catamenial acne: a clinical and bioinstrumental split-face assessment.
Petit, Ludivine; Pierard, Claudine ULiege; Uhoda, Emmanuelle ULiege et al

in Skin Research & Technology (2004), 10(4), 278-82

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without ... [more ▼]

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without, however, clearing the skin condition. AIM: The present open study aimed at evaluating the effect of overnight applications of a paste made of petrolatum,15% zinc oxide and 0.25% miconazole nitrate. METHOD: The split-face trial was conducted in 35 women. A non-medicated cream was used as control. Clinical evaluations and biometrological assessments on cyanoacrylate follicular biopsies were performed monthly for 3 months. Comedometry and the density in autofluorescent follicular casts were used as analytical parameters. In addition, the five most severe cases at inclusion were tested at the completion of the study for follicular bacterial viability using dual flow cytometry. RESULTS: Compared with baseline and to the control hemi-face, the medicated paste brought significant improvement of acne. The number of papules and their redness were reduced beginning with the first treatment phase. A reduction in the follicular fluorescence was yielded beginning with the second treatment phase. The ratios between injured and dead bacteria, on the one hand, and live bacteria, on the other hand were significantly increased at completion of the study. CONCLUSION: A miconazole paste applied for 1 week at the end of the ovarian cycle has a beneficial effect on catamenial acne. [less ▲]

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See detailBiocénose cutanée, peptides antimicrobiens cutanés et antiseptiques.
Flagothier, Caroline ULiege; Uhoda, Emmanuelle ULiege; Goffin, Véronique ULiege et al

in Dermatologie Actualité (2004), 86

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See detailAgeing across the life span: time to think again.
Pierard, Gérald ULiege

in Journal of Cosmetic Dermatology (2004), 3(1), 50-3

Living organisms are subject to ageing. This natural process has gained greater importance in socially and medically affluent societies. For many, ageing connotes unattractive changes in the appearance of ... [more ▼]

Living organisms are subject to ageing. This natural process has gained greater importance in socially and medically affluent societies. For many, ageing connotes unattractive changes in the appearance of the skin. The gross morphological changes of ageing skin are mirrored by a range of more profound age-associated physiological declines. Thus, skin ageing can be put into other perspectives which lie at the interfaces of molecular biology, cellular biology, oncology and cosmetic dermatology. Genetically programmed replicative senescence and stress-induced premature senescence (SIPS) are two processes that are fundamental to skin ageing. Some iteroparous species can be used as animal models for human ageing. Undoubtedly, scientific understanding of skin ageing is firmly rooted in the distinction between intrinsic and extrinsic types of ageing. However, seven major types of skin ageing can be distinguished: genetic, chronological, solar, behavioural, endocrinological, catabolic and gravitational types. Preventative measures can target each of these. [less ▲]

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See detailLe cas clinique du mois. Purpura révélateur d'un rhumatisme articulaire aigu.
Fumal, I.; Henry, Frédérique ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(11), 630-2

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for ... [more ▼]

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for identifying the disease. [less ▲]

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See detailSynopsis des mécanismes pathogéniques des toxidermies graves.
Paquet, Philippe ULiege; Pierard, Gérald ULiege

in Dermatologie Actualité (2004), 85

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See detailLe cas clinique du mois. Fasciolase cutanée.
Garcia Moreno Rodriguez, Renata ULiege; Arrese Estrada, Jorge ULiege; Ugarte, G. et al

in Revue Médicale de Liège (2004), 59(10), 552-4

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel ... [more ▼]

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel treatment. [less ▲]

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See detailUse of reporter cell lines for detection of endocrine-disrupter activity
Willemsen, Philippe; Scippo, Marie-Louise ULiege; Kausel, G. et al

in Analytical and Bioanalytical Chemistry (2004), 378(3), 655-663

We have studied stable transformed human mammary cell lines with highly inducible steroid receptor-mediated luciferase reporter gene expression. Cells responding specifically to glucocorticoids ... [more ▼]

We have studied stable transformed human mammary cell lines with highly inducible steroid receptor-mediated luciferase reporter gene expression. Cells responding specifically to glucocorticoids, progestagens, androgens, or estrogens are described and characterized. The use of this high-throughput, cell-based assay for analysis of steroid (ant)agonists is reported. Systematic characterization of endocrine-disrupting activity on human receptors and in a human-cell system is interpreted for a selection of xenobiotics. We show that the phytoestrogens apigenin and genistin have progestagenic and androgenic activity, respectively. Finally, application of cell-based assays to the analysis of environmental samples is discussed. [less ▲]

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See detailRegulation of opposition and coeducation within a martial arts school
Lenzen, Benoît; Dejardin, Robert; Cloes, Marc ULiege

in STAPS : Revue Internationale des Sciences du Sport et de l'Education Physique (2004), 66

In Japanese martial arts, the regulation of opposition does not lie on impersonal rules as in combat sports. Assuming that a control regulation from the teachers and an autonomous regulation from the ... [more ▼]

In Japanese martial arts, the regulation of opposition does not lie on impersonal rules as in combat sports. Assuming that a control regulation from the teachers and an autonomous regulation from the learners jointly contribute to the solving of this concrete problem, this study tried (1) to identify and describe strategies used by the members (male and female) of a traditional private school to regulate the opposition on the tatami, and (2) to understand the rationality underlying these strategies. A qualitative analysis based on the use of several sources of data (interviews, observations, various documents) and of an original model revealed that what gender considered, the weakest practitioners were driven by a security stake. This common stake was coupled for men with a symbolic stake of preservation of their male sexual status, driving them to adopt tacit avoiding strategies. On the contrary, women negotiated openly with their rough partners, putting their feminine condition forward. The pedagogical intervention should take the existence of such a sexed autonomous regulation into account. [less ▲]

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See detailVaricella-Zoster virus proteins encoded by open reading frames 14 and 67 are both dispensable for the establishment of latency in a rat model.
Grinfeld, Esther; Sadzot-Delvaux, Catherine ULiege; Kennedy, Peter G E

in Virology (2004), 323(1), 85-90

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV ... [more ▼]

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV glycoproteins gC and gI, corresponding to VZV open reading frames (ORFs) 14 and 67, respectively, were required for the establishment of latency in this model. A VZV gI deletion mutant (DeltagI) derived from a recombinant Oka (rOka) cosmid and a gC null mutant obtained from a clinical isolate were inoculated into the footpads of 6-week-old rats, and the presence of viral DNA and eight different VZV RNA transcripts corresponding to the three classes of genes was investigated by in situ RT-PCR amplification and in situ hybridization (ISH) in the DRG at 1 week, 1 month, and 18-24 months after infection. VZV DNA and restricted RNA expression was established with both deletion mutants as well as the parental rOka virus. Both VZV DNA and RNA were detected in neurons and non-neuronal cells. The pattern of viral RNA expression detected with both gC and gI mutants was restricted with transcripts for VZV genes 62 and 63 most frequently expressed 18-24 months after infection. Transcripts for VZV genes 18, 28, and 29 were also detected at these time points but at a slightly lower frequency. Transcripts for the late gene 40 were never detected. We conclude that VZV ORFs 14 and 67 are dispensable for the establishment of a latent infection in this model. [less ▲]

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See detailDrug-eluting stents: meta-analysis in diabetic patients.
Scheen, André ULiege; Warzee, Fabian ULiege; Legrand, Victor ULiege

in European heart journal (2004), 25(23), 2167-82168-9

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See detailContribution to the study of the relations between fish of the family of Carapidae and their holothurian hosts
Parmentier, Eric ULiege

in SPC Bêche de mer, Information Bulletin (2004), 19

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See detailDrei Thesen zur Literaturdidaktik im Fremdsprachenunterricht
Vanhaegendoren, Koen ULiege

in Epos. Revista de filología (2004), 20-21

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See detailAlternative Didaktik im Fremdsprachenunterricht im Zeitraum 1945-1980. Ein Beitrag zur Geschichte der Didaktik
Vanhaegendoren, Koen ULiege

in Zeitschrift der Germanisten Rumäniens (2004), 25-26

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See detailPhénoménologie et personnalisme. Remarques sur le formalisme en éthique de Max Scheler.
Frère, Bruno ULiege

in Archives de Philosophie (2004), 67(3), 445-464

Scheler, remarque Gurvitch, "est arrivé à des résultats qui nous semblent présenter de véritables acquisitions, acquisitions très importantes pour la philosophie contemporaine. Ainsi en est-il de sa ... [more ▼]

Scheler, remarque Gurvitch, "est arrivé à des résultats qui nous semblent présenter de véritables acquisitions, acquisitions très importantes pour la philosophie contemporaine. Ainsi en est-il de sa critique du formalisme kantien et de son analyse phénoménologique de l'intentionnalité émotionnelle". Celles-ci, poursuit-il, sont toutes deux "d’une importance et d’une valeur primordiales". En effet , au coeur d’une époque où l’Allemagne philosophique est plus que jamais féconde, la pensée schelerienne apparaît à beaucoup comme l’une des premières à avoir véritablement "fait ombre à la gloire de Kant" tout en restant sur son terrain. Sans pour autant souscrire à la philosophie du soupçon, il s’écartera définitivement du schéma rationaliste en vigueur depuis l’avènement du cogito cartésien, dont l'auteur des trois critiques compte "parmi les héritiers" et qu’il n’hésite pas à tenir — bien qu'il en reconnaisse la puissance — pour un véritable "tissu d’erreurs du point de vue de son contenu philosophique". Nous voudrions montrer dans cet article que c'est, en Allemagne, une telle critique du cogito qui a permi à Scheler d'ouvrir les voies d'une sociologie phénoménologique, bien avant Schütz. Et même peut-être les voies de la sociologie tout court. [less ▲]

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See detailFrasnian carbonate mounds of the Frasnes area, Belgium
Boulvain, Frédéric ULiege

in IAS Newsletters (2004), 191

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See detailXPS data analysis via Wavelets and Fourier Transform.
Charles, Catherine ULiege; Rasson, Jean-Paul; Leclerc, Gervais

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailL’application de la loi dans le temps en matière de roulage
Jacobs, Ann ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2004)

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See detailLa peine subsidiaire à une peine de travail
Jacobs, Ann ULiege

in Revue de Droit Pénal et de Criminologie (2004)

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See detailLe recyclage urbain en partenariat public-privé : le ''gap funding anglais'' et la ''revitalisation urbaine'' wallonne
Halleux, Jean-Marie ULiege

in Bulletin de la Société Géographique de Liège (2004), 44

Urban recycling and public-private partnership : the English « gap funding » and the Walloon « revitalisation urbaine » The English « gap funding » and the Walloon « revitalisation urbaine » are both ... [more ▼]

Urban recycling and public-private partnership : the English « gap funding » and the Walloon « revitalisation urbaine » The English « gap funding » and the Walloon « revitalisation urbaine » are both, mechanisms of public-private partnership aiming at increasing the financial profitability of urban recycling property development. The objective of their analysis is to understand why, compared with the situation in Wallonia, where the urban regeneration policy has not yet been emblematically successful, the gap funding mechanism has actually led to the renewal of several traditional urban areas. From this comparative investigation, which perfectly illustrates how partnerships are dependent of both, cultural and political traditions, we state that the English success is related with : political choices in favour of the concentration of subsidies within areas where the potential demand is strong, with the transparency of the private financial statements of account and also with a tradition of flexible planning, which is particularly in favour of the setting-up of partnership networks. [less ▲]

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See detailPerquisitions et droits de la défense : une remise en question des pratiques par la Cour européenne des droits de l’homme ?
Jacobs, Ann ULiege

in Revue de Droit Pénal et de Criminologie (2004)

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du ... [more ▼]

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du déroulement de la perquisition. [less ▲]

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See detailATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation
Oury, Cécile ULiege; Sticker, Elsie; Cornelissen, Heidi et al

in Journal of Biological Chemistry (2004)

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released ... [more ▼]

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released from plateletdense granules, and ADP is known to contribute to shear-induced platelet aggregation (SIPA). This study shows that ATP also contributes to SIPA. The ATP-gated P2X(1) ion channel induces MLC-mediated cytoskeletal rearrangements that increases platelet degranulation during VWF-triggered platelet activation. [less ▲]

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See detailValley landscape management : the context of the "river contract" in the Semois Valley (Belgium)
Rosillon, Françis ULiege

in Landscape Research (2004), 29(4), 413-422

A trans-boundary and multi-disciplinary approach to the river contract project for the Semois valley in Wallonia (Belgium) is described that provided the opportunity for a landscape-scale focus during ... [more ▼]

A trans-boundary and multi-disciplinary approach to the river contract project for the Semois valley in Wallonia (Belgium) is described that provided the opportunity for a landscape-scale focus during actions to restore the watercourses and the associated valley area. A trans-boundary landscape survey was carried out under the context of the Interreg III European programme. This resulted in the rediscovery of lost views and viewpoints within the landscape and in the implementation of actions leading to the opening up of the valley, which provided opportunities to re-establish lost landscape features, such as hay meadows. The gathering of many partners in the negotiation process of this project can be seen as an example of 'landscape democratization' or participative management of landscapes in a trans-boundary and trans-disciplinary context and as such this project is a concrete realization of the aims of the European Landscape Convention (ELC). [less ▲]

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See detailLe contrat de rivière Semois : de la qualité de l'eau au tourisme.
Pierre, M.; Rosillon, Françis ULiege

in Espaces, tourisme et loisirs (2004), (213), 50-55

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See detailLes déficits phonologiques des enfants francophones ayant des troubles spécifiques de développement du langage
Parisse, Christophe; Maillart, Christelle ULiege

in Glossa (2004), 89

This study investigated the phonological expressive disorders of Frenchspeaking children with SLI. The main goal of this paper was to confirm whether children with SLI have limitations in phonological ... [more ▼]

This study investigated the phonological expressive disorders of Frenchspeaking children with SLI. The main goal of this paper was to confirm whether children with SLI have limitations in phonological ability even when they are compared with normally-developing children matched by MLU and phonemic inventory size. This was demonstrated by Bortoloni and Leonard (2000), Orsolini et coll. (2001), and Aguilar-Mediavilla et coll. (2002), which obtained the most detailed results in this direction, but it was never tested in French language. The second goal of the paper is to find out whether the characteristics of the French language are reflected in the nature of the children’s phonological disorder. In order to test this, the spontaneous language of 16 children with SLI and of 16 control children matched on MLU and phonemic inventory size (NLD group) was analysed using different measures bearing on utterances, words, syllables, or phonemes. In both SLI and NLD groups, the children were distributed in two different subgroups, on the basis of their MLU and phonemic inventory size. The results supported a specific limitation in the phonological abilities of French children with SLI, as was already demonstrated for English, Hebrew, Italian, and Spanish-Catalan. However, two unexpected results were also obtained. Firstly, a significant difference between children with SLI and control children could only be found for older children (MLU above 3), not for younger children with MLU below 3. This was true for all measures. This finding stresses out the importance of having a development perspective and has to be confirmed with longitudinal design. Secondly, deficits were much more important at the phoneme level than at the syllable level. This can be explained by the fact that the French language has a very homogenous pronunciation of syllables, which makes them easier to segment. [less ▲]

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See detailLe coût cognitif des processus orthographiques
Schelstraete, Marie-Anne; Maillart, Christelle ULiege

in Glossa (2004), 89

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See detailRegistration and real-time visualization of transcranial magnetic stimulation with 3-D MR images.
Noirhomme, Quentin ULiege; Ferrant, Matthieu; Vandermeeren, Yves et al

in IEEE Transactions on Biomedical Engineering (2004), 51(11), 1994-2005

This paper describes a method for registering and visualizing in real-time the results of transcranial magnetic stimulations (TMS) in physical space on the corresponding anatomical locations in MR images ... [more ▼]

This paper describes a method for registering and visualizing in real-time the results of transcranial magnetic stimulations (TMS) in physical space on the corresponding anatomical locations in MR images of the brain. The method proceeds in three main steps. First, the patient scalp is digitized in physical space with a magnetic-field digitizer, following a specific digitization pattern. Second, a registration process minimizes the mean square distance between those points and a segmented scalp surface extracted from the magnetic resonance image. Following this registration, the physician can follow the change in coil position in real-time through the visualization interface and adjust the coil position to the desired anatomical location. Third, amplitude of motor evoked potentials can be projected onto the segmented brain in order to create functional brain maps. The registration has subpixel accuracy in a study with simulated data, while we obtain a point to surface root-mean-square error of 1.17+/-0.38 mm in a 24 subject study. [less ▲]

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See detailThe effect of growth at low temperature on the activity and expression of the uncoupling protein in Acanthamoeba castellanii mitochondria.
Jarmuszkiewicz, W.; Antos, N.; swida, A. et al

in FEBS Letters (2004), 569

Mitochondria of amoeba Acanthamoeba castellanii, a non-photosynthetic soil amoeboid protozoon, possess an uncoupling protein (AcUCP) that mediates free fatty acid-activated proton re-uptake dissipating ... [more ▼]

Mitochondria of amoeba Acanthamoeba castellanii, a non-photosynthetic soil amoeboid protozoon, possess an uncoupling protein (AcUCP) that mediates free fatty acid-activated proton re-uptake dissipating the proton electrochemical gradient built up by respiration. The present study provides the first evidence that UCP could be a cold response protein in unicellulars. In mitochondria isolated from an amoeba batch culture grown temporarily at low temperature (6 degrees C), the content of AcUCP was increased and correlated with an increase in the linoleic acid (LA)-stimulated UCP-mediated carboxyatractyloside-resistant state 4 respiration, as compared to a control culture (routinely grown at 28 degrees C). Moreover, the cytochrome pathway activity was found to be insensitive to the cold exposure of amoeba cells, as indicated by respiration and membrane potential measurements as well as by an absence of change in the adenine nucleotide translocator and cytochrome oxidase expression levels. Furthermore, in mitochondria from the low-temperature-grown cells, at fixed LA concentration, the increased contribution of AcUCP activity to total mitochondrial phosphorylating respiration accompanied by lower coupling parameters was found, as was confirmed by calculation of this contribution using ADP/O measurements. [less ▲]

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See detailHealth-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: An international multicenter study
Efficace, F.; Therasse, P.; Piccart, M. J. et al

in Journal of Clinical Oncology (2004), 22(16), 3381-3388

Purpose The purpose of this research was to evaluate whether baseline health-related quality of life (HRQOL) parameters are prognostic factors for survival in locally advanced breast cancer patients ... [more ▼]

Purpose The purpose of this research was to evaluate whether baseline health-related quality of life (HRQOL) parameters are prognostic factors for survival in locally advanced breast cancer patients. Although the literature highlights the important role of HRQOL parameters in predicting survival in advanced metastatic disease, little evidence exists for earlier stages. Patients and Methods The overall sample consisted of 448 patients randomly assigned to receive cyclophosphamide, epirubicin, and fluorouracil versus epirubicin, cyclophosphamide, and granulocyte colony-stimulating factor. Patients were enrolled in 12 countries. HRQOL baseline scores were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. In addition, a bootstrap resampling technique was used to assess the stability of the outcomes. Bootstrap results were then applied for model averaging purposes as a means to account for the observed model selection uncertainty. Results The final multivariate model retained inflammatory breast cancer (T4d) as the only factor predicting overall survival (OS) with a hazard ratio of 1.375 (95% CI, 1.027 to 1.840; P = .03). The presence of inflammatory breast cancer lowers the median survival time from 6.6 to 4.2 years (36% reduction). None of the preselected HRQOL variables were prognostic for OS or disease-free survival, in either the univariate or multivariate analysis. Conclusion Our findings suggest that baseline HBQOL parameters have no prognostic value in a nonmetastatic breast cancer population. [less ▲]

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See detailComparisons of finite element and Rayleigh methods for the study of conical Bloch waves in arrays of metallic cylinders
Guenneau, S.; Nicolet, A.; Geuzaine, Christophe ULiege et al

in COMPEL (2004), 23(4), 932--949

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See detailValorisation industrielle de la pomme de terre.
Delaplace, Pierre ULiege; Fauconnier, Marie-Laure ULiege

in Troupeaux et Cultures des Tropiques (2004)

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See detailLa production de gros bois de résineux : une opportunité économique et écologique?
Delahaye, L.; Colson, Vincent ULiege; Graux, G. et al

in Parcs & Réserves (2004), 59(4), 28-32

Cette note tente de faire la synthèse d'un colloque organisé par Pro Silva (Belgique-Suisse-Allemagne-France) le 17 sept. 2003 à Sasbachwalden (D) sur le thème "Gros bois résineux : une chance pour la ... [more ▼]

Cette note tente de faire la synthèse d'un colloque organisé par Pro Silva (Belgique-Suisse-Allemagne-France) le 17 sept. 2003 à Sasbachwalden (D) sur le thème "Gros bois résineux : une chance pour la sylvicultute et l'utilisation du bois". L'objectif de ce colloque était de rassembler les connaissances sur les ressources en gros bois en France, en Allemagne du Sud-Ouest et en Suisse, leurs utilisations dans l'industrie et leur évaluation en terme de biodiversité. Ce compte-rendu est complété par quelques réflexions sur la production de gros bois résineux en Région wallonne. [less ▲]

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See detailInventaire forestier de gestion : proposition d'un cadre méthodologique et technique
Lejeune, Philippe ULiege; Rondeux, Jacques ULiege

in Forêt Wallonne (2004), (73), 22-29

Confronté à des sollicitations de plus en plus nombreuses envers la forêt, le gestionnaire forestier doit pouvoir disposer d’informations adaptées à la complexité des analyses qu’il est amené à réaliser ... [more ▼]

Confronté à des sollicitations de plus en plus nombreuses envers la forêt, le gestionnaire forestier doit pouvoir disposer d’informations adaptées à la complexité des analyses qu’il est amené à réaliser. Les progrès récents en matière de cartographie donnent accès à une information très précieuse. L’inventaire forestier reste cependant l’outil le plus adapté pour une description, tant qualitative que quantitative, des peuplements et de leurs diverses composantes. Ces inventaires ne peuvent cependant plus se limiter au simple recensement du matériel sur pied présent au sein des différentes parcelles d’une propriété. [less ▲]

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See detailL’ironie dans Ounamon : les emplois de mk et de ptr
Winand, Jean ULiege

in Göttinger Miszellen (2004), (200), 105-110

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See detailValidation of two nonlinear system identification techniques using an experimental testbed
Lenaerts, V.; Kerschen, Gaëtan ULiege; Golinval, Jean-Claude ULiege et al

in Shock and Vibration (2004), 11(3-4), 365-375

The identification of a nonlinear system is performed using experimental data and two different techniques, i.e. a method based on the Wavelet transform and the Restoring Force Surface method. Both ... [more ▼]

The identification of a nonlinear system is performed using experimental data and two different techniques, i.e. a method based on the Wavelet transform and the Restoring Force Surface method. Both techniques exploit the system free response and result in the estimation of linear and nonlinear physical parameters. [less ▲]

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See detailHREELS Signal Processing Via Wavelets.
Charles, Catherine ULiege; Leclerc, Gervais; Rasson, Jean-Paul

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailDouces transgressions : notes sur "La Perle" (H. d'Ursel, 1929)
Belloi, Livio ULiege

in Mélusine. Cahiers du Centre de Recherche sur le Surréalisme (2004), 26

Cette étude consiste en une lecture approfondie et contextualisante d’un film belge peu connu, à savoir "La Perle" (Henri d’Ursel, 1929, sur un scénario du poète Georges Hugnet). De cet examen ... [more ▼]

Cette étude consiste en une lecture approfondie et contextualisante d’un film belge peu connu, à savoir "La Perle" (Henri d’Ursel, 1929, sur un scénario du poète Georges Hugnet). De cet examen circonstancié et spécialement attentif aux phénomènes d’intertextualité, il ressort notamment que "La Perle" tranche à bien des égards avec les autres grandes œuvres cinématographiques habituellement placées sous la bannière du surréalisme (les films de Bunuel et Dali, de Germaine Dulac, de Man Ray, etc.). En particulier, le film d’Henri d’Ursel se règle sur le principe d’une transgression douce, observant apparemment les conventions narratives, mais dans le seul but de mieux les miner de l’intérieur. Rien de très spectaculaire dans "La Perle", sinon l’expression même des tiraillements intimes dont l’esthétique surréaliste se trouve affectée, entre culture populaire (référence aux "Vampires", le célèbre film à épisodes de Louis Feuillade) et raréfaction poétique (allusion à Stéphane Mallarmé et à son "Coup de dés"). [less ▲]

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See detailMise en évidence des zones touchées par la désertification par télédétection a basse résolution au Niger
Hountondji, Yvon ULiege; Ozer, Pierre ULiege; Nicolas, Jacques ULiege

in Cybergeo : Revue Européenne de Géographie = Cybergeo - European Journal of Geography (2004)

In order to identify areas where desertification may have occurred over the last two decades, 109 stations located in three bioclimatic zones of Niger are analyzed. Time series of remote sensing data are ... [more ▼]

In order to identify areas where desertification may have occurred over the last two decades, 109 stations located in three bioclimatic zones of Niger are analyzed. Time series of remote sensing data are well suited to this task. Here, we use time series of NOAA AVHRR normalized difference vegetation index (NDVI) data and rainfall data. In this study, trend analysis is used to identify areas within the biomes from 1981 to 1999 in Niger with apparent land degradation in semi-arid areas. It appears that most of Niger (98%) recorded increasing rainfall while only 76% experienced increasing maximum NDVI. However, the combination of the two variables through the ratio shows a widespread reduction of the rain-use efficiency with non significant trend for the stations located in northern Sahel (p=0.52), highly significant for those located in central Sahel (p=0.00009) and significant in southern Sahel (p=0.041). Overall, 75.3% of the sample recorded a significant reduction of the NDVIMax/RR ratio. Only one station out of four (24.7%) presented a stability of the ratio. These negative trends suggest a progressive diminution of the vegetation productivity as highlighted by the lowering of the NDVIMax/RR ratio. This situation suggest a consistently environmental degradation and that desertification processes continued during the last two decades over most of the Sahelian belt of Niger. [less ▲]

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See detailLeçon inaugurale : entre mythes et défis, la forêt en devenir
Rondeux, Jacques ULiege

in Bulletin d'Information (Association Royale des Ingénieurs Issus de la Fusagx - Aigx) (2004), (5), 9-15

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See detailHa una pistola per eliminare mio marito?
D'Amore, Salvatore ULiege

in Ecologia della Mente (2004), 26(1), 71-102

Recent theoretical and clinical contributions of elderly couple with alcoholic partner underlies the usefulness of pragmatic/interactive and semantic/symbolic approach of symptomatic situation ... [more ▼]

Recent theoretical and clinical contributions of elderly couple with alcoholic partner underlies the usefulness of pragmatic/interactive and semantic/symbolic approach of symptomatic situation. Particularly, alcohol-dependance is understood as related to developmental tasks, resources and bonds of life-cycle of elderly age. A psychotherapeutic process of elderly couple is narrated. This work is caractherized by the following phases: alcoholistic symptom control, individual and family story narration and renegociation and reshaping of couple spaces/times. Symptom gradual dissolution has permitted the relaunching of individual, couple and familial planning as a fundamental dimension for improving general quality life of elderly couple. [less ▲]

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See detailIntroducing the multivariate dale model in population-based genetic association studies
Van Steen, Kristel ULiege; Tahri, N.; Molenberghs, G.

in Biometrical Journal = Biometrische Zeitschrift (2004), 46(2), 187-202

Until recently, the most common parametric approaches to study the combined effects of several genetic polymorphisms located within a gene or in a small genomic region are, at the genotype level, logistic ... [more ▼]

Until recently, the most common parametric approaches to study the combined effects of several genetic polymorphisms located within a gene or in a small genomic region are, at the genotype level, logistic regressions and at the haplotype level, haplotype analyses. An alternative modeling approach, based on the case/control principle, is to regard exposures (e.g., genetic data such as derived from Single Nucleotide Polymorphisms - SNPs) as random and disease status as fixed and to use a marginal multivariate model that accounts for inter-relationships between exposures. One such model is the multivariate Dale model. This model is based on multiple logistic regressions. That is why the model, applied in a case/control setting, leads to straightforward interpretations that are similar to those drawn in a classical logistic modeling framework. [less ▲]

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See detailInfluence of breathing pattern and lung inflation on impulse oscillometry measurements in horses.
Van Erck, Emmanuelle; Votion, Dominique ULiege; Kirschvink, Nathalie et al

in Veterinary Journal (2004), 168(3), 259-69

The objective of this paper was to determine if changes in ventilation patterns could influence the outcome of respiratory function measurements performed with our impulse oscillometry system (IOS) in ... [more ▼]

The objective of this paper was to determine if changes in ventilation patterns could influence the outcome of respiratory function measurements performed with our impulse oscillometry system (IOS) in horses. In a first study, IOS tests were performed in vitro on six isolated equine lungs. Lung inflation levels were controlled by modifying depressurisation inside an artificial thorax and different ventilation patterns were imposed. In a second in vivo study, transient variations in breathing pattern were evaluated both with the IOS and a current reference technique (CRT) in five healthy mature horses after an intravenous (i.v.) injection of lobeline hydrochloride. In both studies, respiratory rate (RR, range: 7-42 breaths/min.) and tidal volume (V(T), range: 0.4-25 L) had minor or no influence on IOS parameters. The influence of lung inflation, most marked for resistance at 5 Hz (R(5 Hz)), was limited for the considered physiological range. In vivo, statistical models indicated that maximal changes in pleural pressure (Max Delta Ppl) and peak flows were the main determinants of the variability of the resistance (R(rs)) and the reactance (X(rs)) of the respiratory system. The fourfold increase in baseline Max Delta Ppl and peak flows obtained during hyperpnoea caused a significant increase in R(rs) at 5 and 10 Hz and a decrease in X(rs) at all frequencies. We conclude that IOS parameters are not influenced by tachypnoea, but will reflect alterations in respiratory mechanics caused by hyperpnoeic breathing [less ▲]

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See detailReduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants.
Debacq, Christophe; Sanchez Alcaraz, Maria Teresa; Mortreux, Franck et al

in Retrovirology (2004), 1(1),

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See detailGenome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13.
Shibamura, Hidenori; Olson, Jane M; van Vlijmen-Van Keulen, Clarissa et al

in Circulation (2004), 109(17), 2103-8

BACKGROUND: Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs ... [more ▼]

BACKGROUND: Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs, although no such risk factors have been identified. METHODS AND RESULTS: We performed a whole-genome scan of AAA using affected-relative-pair (ARP) linkage analysis that includes covariates to allow for genetic heterogeneity. We found strong evidence of linkage (logarithm of odds [LOD] score=4.64) to a region near marker D19S433 at 51.88 centimorgans (cM) on chromosome 19 with 36 families (75 ARPs) when including sex and the number of affected first-degree relatives of the proband (N(aff)) as covariates. We then genotyped 83 additional families for the same markers and typed additional markers for all families and obtained a LOD score of 4.75 (P=0.00014) with sex, N(aff), and their interaction as covariates near marker D19S416 (58.69 cM). We also identified a region on chromosome 4 with a LOD score of 3.73 (P=0.0012) near marker D4S1644 using the same covariate model as for chromosome 19. CONCLUSIONS: Our results provide evidence for genetic heterogeneity and the presence of susceptibility loci for AAA on chromosomes 19q13 and 4q31. [less ▲]

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See detailDate seed oil: Phenolic, tocopherol and sterol profiles
Besbes, S.; Blecker, Christophe ULiege; Deroanne, Claude ULiege et al

in Journal of Food Lipids (2004), 11(4), 251-265

Oils extracted from the seeds of two date palm (Phoenix dactylifera L) cultivars, Deglet Nour and Allig, collected from Tunisia, were compared in terms of phenolic, tocopherol and,sterol profiles. These ... [more ▼]

Oils extracted from the seeds of two date palm (Phoenix dactylifera L) cultivars, Deglet Nour and Allig, collected from Tunisia, were compared in terms of phenolic, tocopherol and,sterol profiles. These minor components are not only very important for functional properties of oils (oxidation resistance, taste, aroma and color), but could also have many health benefits. Total phenols, considered as the principal source of oil oxidation resistance, ranged from 520.81 for Deglet Nour to 220.32 mg/kg for Allig. High performance liquid chromatography revealed eight identified peaks for which the major component was hydroxytyrosol (10.21%) for Deglet Nour and tyrosol for Allig (8.10%). Total sterol content was 3500 and 3000 mg/kg for Deglet Nour and Allig, respectively. The sterol marker, beta-sitosterol, accounted for 83.31 and 78.66% of total sterols in Deglet Nour and Allig seed oils, respectively. Alpha-tocopherol was the predominant component in both date seed oils (24.97-38.85%). [less ▲]

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See detailComparison of two methods currently used to determine the interaction between cyclodextrins and drugs: phase solubility diagrams and NMR spectroscopy
Piel, Géraldine ULiege; Moutard, Stephane; Perly, Bruno et al

in Journal of Drug Delivery Science and Technology (2004), 14(1, JAN-FEB), 87-91

Two methods usually used in the literature to determine stability constant values (Kc) of cyclodextrin complexes were compared: the phase solubility diagram and NMR spectroscopy. Two model drugs were used ... [more ▼]

Two methods usually used in the literature to determine stability constant values (Kc) of cyclodextrin complexes were compared: the phase solubility diagram and NMR spectroscopy. Two model drugs were used to determine limitations of both techniques: betamethasone and miconazole, with three cyclodextrins: beta-cyclodextrine (betaCD), dimethylated-betaCD (Dimeb) and trimethylated-betaCD (Trimeb). This study shows that both techniques can give the same Kc value if they are used in exactly the same conditions with well defined cyclodextrins. As a matter of fact, if the degree of substitution of cyclodextrin is not well defined (as it is often the case with Dimeb), results are biased. This study also shows that when interactions between both molecules are weak (< 1000 M-1), stability constants can not be determined by NMR due to low chemical shift variations. The limitations of the phase solubility diagram method are an oversimplification of the solubility data which can lead to large errors in the calculation of the stability constant values. Moreover, this method is time and material consuming. [less ▲]

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See detailMitochondrial respiratory chain complex patterns from Acanthamoeba castellanii and Lycopersicon esculentum: comparative analysis by BN-PAGE and evidence of protein-protein interaction between alternative oxidase and complex III.
Navet, R.; Jarmuszkiewicz, W.; Douette, P. et al

in Journal of Bioenergetics & Biomembranes (2004), 36(5), 471-479

We have previously shown that a kinetic interplay exists between the cytochrome pathway and the alternative oxidase in mitochondria from amoeba Acanthamoeba castellanii . Native interaction analyses using ... [more ▼]

We have previously shown that a kinetic interplay exists between the cytochrome pathway and the alternative oxidase in mitochondria from amoeba Acanthamoeba castellanii . Native interaction analyses using blue native gel electrophoresis coupled to denaturating electrophoresis and immunodetection have indicated associations between alternative oxidase and oxidative phosphorylation complexes in both amoeba and tomato mitochondria. These associations are dependent on the expression level of alternative oxidase according to the physiological state in both organisms. Alternative oxidase associates broadly with large complexes of the respiratory chain when it is expressed in large amount, i.e., in ripe tomato and exponentially growing amoeba. On the contrary, alternative oxidase interacts specifically with complex III even if expression of the oxidase is low, i.e., in green tomato and stationary phase amoeba. This specific interaction represents a higher level of regulation driven by protein-protein interactions leading to a direct kinetic interplay between the cytochrome pathway and alternative oxidase in both plant and amoeba mitochondria. [less ▲]

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See detailBoost Customer Loyalty With Online Support: The Case of Mobile Telecoms Providers
Van Riel, Allard ULiege; Lemmink, Jos; Streukens, Alexandra ULiege et al

in International Journal of Internet Marketing and Advertising (2004), 1(1), 4-23

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See detailDatabase and general modelling concepts for groundwater modelling in the SQUASH Project
Orban, Philippe ULiege; Popescu, Ileana-Cristina; Ruthy, Ingrid ULiege et al

in Hidrotehnica (2004), 49(9-10), 51-57

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See detailOnline travel service quality: The role of pre-transaction services
Van Riel, Allard ULiege; Semeijn, Janjaap; Pauwels, Pieter

in Total Quality Management & Business Excellence (2004), 15(4), 475-493

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See detailPhysicochemical properties and technological functionality of dietary fibres.
Elleuch; Roiseux, Olivier; Blecker, Christophe ULiege et al

in Food Chemistry (2004), (6), 115-124

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See detailAggregate Matching Efficiency: A Stochastic Production Frontier Approach, France 1990–1994
Ibourk, Aomar; Maillard, Bénédicte; Perelman, Sergio ULiege et al

in Empirica (2004), 31

We evaluate the determinants of aggregate matching efficiency changes through a stochastic translog production frontier model. The efficiency coefficient is represented by a stochastic function of ... [more ▼]

We evaluate the determinants of aggregate matching efficiency changes through a stochastic translog production frontier model. The efficiency coefficient is represented by a stochastic function of variables meant to capture workers and firms characteristics. The model is estimated on French data covering twenty-two regions from March 1990 till February 1995. Our estimates suggest that aggregate matching efficiency has decreased steadily in the early nineties. There are also wide cross-regional differences. On average, about 30% of the variations of efficiency observed across time and regions can be related to changes in the explanatory variables used in the model. The most important explanatory variables are the proportion of youngsters, females and immigrants in the stock of job seekers. Long-term unemployment has a significant negative effect, population density a significant positive one. The huge decline in the proportion of permanent job offers has apparently little effect on matching efficiency. [less ▲]

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See detailMineral mapping in salt lakes from Sud Lipez (Bolivia) using Aster images
Caceres, Fernando; Ali-Ammar, Hamid; Pirard, Eric ULiege

in Geological Remote Sensing Group Newsletter (2004), (38), 15-19

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See detailClinical pharmacokinetics of once-daily molsidomine - From immediate-release to prolonged-release once-daily formulations
Herchuelz, André; Carreer-Bruhwyler, Fabienne; Crommen, Jacques ULiege et al

in American Journal of Drug Delivery (2004), 2(2), 131-141

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See detailOnderzoek en praktijk in de Franstalige neerlandistiek
Spinoy, Erik ULiege; Janssens, Guy ULiege; Sereni, Sabrina

in n/f (2004), 4

This volume collects the revised papers of the december 2003 Conference (Liège) of the Association des neerlandistes de Belgique francophone.

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See detailParavion : Hafid Bouazza tussen het particuliere en het universele
Spinoy, Erik ULiege

in Nieuwzuid (2004), 4(14), 4-14

This article is a reading of the novel Paravion by the Dutch-Moroccon novelist, focusing on the tension between the universal and the particular this novel bears witness to.

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See detailTélédétection et télégestion des informations géologiques : de nouvelles technologies au service du développement.
Pirard, Eric ULiege; Caceres, Fernando

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2004), 50(3), 321-348

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See detailA benchmark for methods in reverse engineering and model discrimination: Problem formulation and solutions
Kremling, Andreas; Fischer, Sophia; Gadkar, Kapil et al

in Genome Research (2004), 14(9), 1773-1785

A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one ... [more ▼]

A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one substrate is fed into the reactor with a given feed rate and feed concentration. Measurements for some intracellular components are provided representing a small biochemical network. Problems of reverse engineering, parameter estimation, and identifiability are addressed. The contribution mainly focuses oil the problem of model discrimination. If two or more model variants describe the available experimental data, a new experiment must be designed to discriminate between the hypothetical models. For the problem presented, the feed rate and feed concentration of a bioreactor system are available as control inputs. To verify calculated input profiles an interactive Web site (http://www.sysbio.de/projects/benchmark/) is provided. Several solutions based oil linear and nonlinear models are discussed. [less ▲]

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See detailReduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling
Conzelmann, Holger; Saez-Rodriguez, Julio; Sauter, Thomas et al

in IEE Proceedings - Systems Biology (2004), 1(1), 159-169

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain ... [more ▼]

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain qualitative and, most importantly, quantitative knowledge about such complex systems. However, a detailed mathematical description of these systems leads to nearly unmanageably large models, especially when combining models of different signalling pathways to study cross-talk phenomena. Therefore, simplification of models becomes very important. Different methods are available for model reduction of biological models. Importantly, most of the common model reduction methods cannot be applied to cellular signal transduction pathways. Using as an example the epidermal growth factor (EGF) signalling pathway, we discuss how quantitative methods like system analysis and simulation studies can help to suitably reduce models and additionally give new insights into the signal transmission and processing of the cell [less ▲]

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See detailQuelques observations sur la qualification d'un fait en matière pénale et sur les notions d'invalidité et d'incapacité
Michiels, Olivier ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2004), 3

L'article fait le point sur la qualification d'un fait pénal par défaut et sur les principes applicables à la qualification sur opposition. Il distingue encore les notions d'invalidité et d'incapacité.

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See detail3. Chiuse poetiche e senso della fine: Spunti per una tipologia
Benzoni, Pietro ULiege

in Quaderns d'Italià (2004)

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See detailWavelet Applications in Surface Science: a comparison to Fourier transform.
Charles, Catherine ULiege; Rasson, Jean-Paul; Pireaux, Jean-Jacques et al

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailAngioplastie percutanee coronaire chez le patient diabetique. Partie 2: Espoirs apportes par les protheses endovasculaires.
Warzee, Fabian ULiege; Legrand, Victor ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(11), 653-8

Coronary artery revascularization procedures provide less favourable results in diabetic patients than in non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is associated with ... [more ▼]

Coronary artery revascularization procedures provide less favourable results in diabetic patients than in non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is associated with a higher rate of restenosis and recurrence of cardiac morbidity and death. In diabetic patients, PTCA should, if possible, be combined with a stent. Bare-stents allow to reduce approximately by half the risk of restenosis, but unfortunately their efficacy decreases as the vessel diameter decreases, a common finding among diabetic patients with angiopathy. ARTS ("Arterial Revascularization Therapy Study") recently showed that diabetic patients have a worse prognosis even when bare-stents are combined with PTCA as compared to non-diabetic subjects and as compared to diabetic patients treated with coronary artery bypass graft. These results open new perspectives in favour of the use of drug-eluting stents containing pharmacological agents capable of preventing restenosis. Such new stents might improve the management of diabetic patients with coronary heart disease. [less ▲]

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See detailLa loi du 6 janvier 2003 concernant les méthodes particulières de recherche et quelques autres méthodes d’enquête : un tournant dans la procédure pénale belge
Jacobs, Ann ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2004)

analyse de la loi du 6 janvier 2003 introduisant les méthodes particulières de recherche en droit belge

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See detailSubtype Selective Substrates For Histone Deacetylases
Heltweg, B.; Dequiedt, Franck ULiege; Marshall, Bl. et al

in Journal of Medicinal Chemistry (2004), 47(21),

To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver ... [more ▼]

To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver, human HeLa, and human recombinant class I and II histone deacetylases (HDACs) as well as human recombinant NAD(+)-dependent SIRT1 (class III enzyme) were used in these studies. A benzyloxycarbonyl substituent on the alpha-amino group yielded the highest conversion rates. Replacing the epsilon-acetyl group with larger lipophilic acyl substituents led to a pronounced decrease in conversion by class I and II enzymes; the class III enzyme displayed a greater tolerance. Incubations with recombinant FLAG-tagged human HDACs 1, 3, and 6 showed a distinct subtype selectivity among small molecule substrates. The subtype selectivity of HDAC inhibitors could be predicted with these substrates and an easily obtainable mixture of HDAC subtypes. [less ▲]

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See detailProbing the origins, diagnosis and treatment of amyloid diseases using antibodies.
Dumoulin, Mireille ULiege; Dobson, Christopher

in Biochimie (2004), 86

The deposition of proteins in the form of amyloid fibrils is the characteristic feature of more than 20 medical conditions affecting the central nervous system or a variety of peripheral tissues. These ... [more ▼]

The deposition of proteins in the form of amyloid fibrils is the characteristic feature of more than 20 medical conditions affecting the central nervous system or a variety of peripheral tissues. These disorders, which include Alzheimer's disease, the prion diseases and type II diabetes, are of enormous importance in the context of present-day human health and welfare. Extensive research is therefore being carried out to define the molecular details of the mechanism of the pathological conversion of amyloidogenic proteins from their soluble forms into fibrillar structures. This review focuses on recent studies that demonstrate the power of using antibodies or antibody fragments to probe the process of fibril formation, and discusses the emerging potential of these species as diagnostic and therapeutic agents. [less ▲]

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See detailAdaptation et test d'un nez électronique pour suivre en continu la nuisance olfactive générée par un centre de compostage
Ledent, Catherine; Dauby, B.; Nicolas, Jacques ULiege et al

in Revue scientifique des instituts supérieurs industriels libres francophones (2004), 18

L'article présente le travail de fin d'études de Catherine Ledent. Celui-ci a consisté à la mise au point et au test sur le terrain (sur le centre de compostage à Habay) d'un nez électronique destiné à ... [more ▼]

L'article présente le travail de fin d'études de Catherine Ledent. Celui-ci a consisté à la mise au point et au test sur le terrain (sur le centre de compostage à Habay) d'un nez électronique destiné à être placé en continu sur un site industriel, de manière à détecter des occurrences d'odeur. Le prototype existant a été adapté de manière à satisfaire aux exigences du terrain. Par exemple, une régulation thermique de la chambre des capteurs a permis de s'affranchir des variations de température de l'ambiance. La phase de validation sur le terrain fut la plus exigeante: elle nécessitait en effet une présence constante de l'étudiante sur le terrain, de manière à identifier les causes possibles de variation des capteurs. En finale, le système a montré d'excellentes performances et peut servir de base à un développement technologique ultérieur. [less ▲]

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See detailSuppression Of Tumor Growth And Cell Proliferation By P13(Ii), A Mitochondrial Protein Of Human T Cell Leukemia Virus Type 1
Silic-Benussi, M.; Cavallari, L.; Zorzan, T. et al

in Proceedings of the National Academy of Sciences of the United States of America (2004), 101(17),

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See detailEffect of non-steroidal anti-inflammatory drugs on amyloid-beta formation and macrophage activation after platelet phagocytosis.
Jans, Dominique ULiege; Martinet, Wim; Fillet, Marianne ULiege et al

in Journal of Cardiovascular Pharmacology (2004), 43(3), 462-70

Recently, we showed that platelet phagocytosis occurs in human atherosclerotic plaques and leads to foam cell formation. Platelet phagocytosis, resulting in macrophage activation and iNOS induction, was ... [more ▼]

Recently, we showed that platelet phagocytosis occurs in human atherosclerotic plaques and leads to foam cell formation. Platelet phagocytosis, resulting in macrophage activation and iNOS induction, was associated with the formation of amyloid-beta peptide (Abeta) via proteolytic cleavage of platelet-derived amyloid precursor protein (APP), possibly by secretases. To test the involvement of gamma-secretase in this process, we used indomethacin, ibuprofen, and sulindac sulfide, non-steroidal anti-inflammatory drugs (NSAIDs) known to alter the gamma-secretase cleaving site of APP, on their ability to inhibit macrophage activation evoked by platelet phagocytosis. J774 macrophages were incubated with human platelets or lipopolysaccharide (LPS) with or without NSAIDs. Nitrite was quantified as a measure for inducible nitric oxide synthase (iNOS) activity. Indomethacin, ibuprofen, sulindac sulfide, and meloxicam concentration-dependently reduced nitrite production by macrophages incubated with platelets, but did not alter LPS-induced iNOS activity or platelet uptake. However, acetylsalicylic acid and naproxen, two NSAIDs without effect on the gamma-secretase cleaving site of APP, did not affect nitrite production in either platelet- or LPS-stimulated macrophages. Surface-enhanced laser desorption/ionization time-of-flight mass-spectrometry demonstrated time-dependent formation of Abeta-containing peptides after platelet phagocytosis, which could be inhibited by indomethacin. In conclusion, these results point to the involvement of gamma-secretase in macrophage activation following platelet phagocytosis. [less ▲]

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See detailMélanges fleuris et insectes auxiliaires
Francis, Frédéric ULiege; Colignon, P.; Haubruge, Eric ULiege

in Canard Déchaîné du Kauwberg (Le) (2004), 50

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See detailCyclodextrins as a potential carrier in drug nebulization.
Evrard, Brigitte ULiege; Bertholet, P.; Guéders, Maud ULiege et al

in Journal of Controlled Release (2004), 96(3), 403-10

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. [less ▲]

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See detailRéseaux de surveillance des masses d’eau souterraine en Région Wallonne
Rentier, Céline; Delloye, Francis; Dassargues, Alain ULiege

in Tribune de l'Eau (La) (2004), (631-632), 11-21

La mise en œuvre de la directive européenne cadre de l’eau nécessite l’élaboration, par masse d’eau souterraine, d’un réseau de mesure et de surveillance aussi représentatif que possible de l’état des ... [more ▼]

La mise en œuvre de la directive européenne cadre de l’eau nécessite l’élaboration, par masse d’eau souterraine, d’un réseau de mesure et de surveillance aussi représentatif que possible de l’état des eaux souterraines. En Région Wallonne, cinq masses d’eau de caractéristiques différentes d’un point de vue géologique, hydrogéologique et d’occupation du sol ont fait l’objet d’une étude en vue d’établir une stratégie de sélection des sites de mesures. La sélection des stations de mesure composant chaque réseau a été réalisé en tenant compte de divers critères tels que la géologie, l’hydrogéologie et l’hydrochimie de la masse d’eau, les caractéristiques des points d’eau existants, mais aussi la densité et la répartition spatiale des ouvrages sélectionnés. Le système d’évaluation de la qualité des eaux souterraines SEQESO adopté en Région Wallonne a été appliqué à chacun de ces réseaux afin d’apprécier l’état chimique de ces masses d’eaux conformément à la directive-cadre. The implementation of the European water framework directive requires the construction of monitoring networks being as far as possible representative of the global water quality in each groundwater body. In Walloon Region, five groundwater bodies with different contrasted geological conditions, hydrogeological conditions and soil occupancy, were studied in order to establish an approach for choosing an adequate network of monitoring points. This selection was realized by considering different criterions as the groundwater geology, hydrogeology and hydrochemistry, the feature of existing waterpoints, but also the density and the spatial distribution of the selected points in order to obtain a statistically representative network. The quality assessment system for groundwater (SEQESO) adopted by the Walloon Region has been applied to the five monitoring networks in order to fully appreciate the chemical status of the groundwater bodies in accordance with the European directive. [less ▲]

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See detailCommunity-based wildlife management in Burkina Faso : the experiments of the Nazinga Ranch and W park
Vermeulen, Cédric ULiege

in Game and Wildlife Science (2004), 21(3), 313-326

Le Burkina Faso reste le seul pays d’Afrique occidentale à posséder une législation où, au moins légalement, la gestion cynégétique de la faune sauvage par les populations locales est devenue une réalité ... [more ▼]

Le Burkina Faso reste le seul pays d’Afrique occidentale à posséder une législation où, au moins légalement, la gestion cynégétique de la faune sauvage par les populations locales est devenue une réalité. Les textes de loi prévoient en effet la possibilité pour les populations de délimiter sur leurs terroirs des zones dévolues à la chasse commerciale, d’y faire venir des chasseurs et de rétrocéder à l’État la part des recettes qui lui est due. La loi prévoit également la constitution de Comités Villageois de Gestion de la Faune (CVGF), structures rattachées aux Comités Villageois de Gestion de Terroir (CVGT) et reconnues dans le processus de décentralisation en cours. L’opportunité de construire une conservation de la faune sauvage servant directement le développement local existe donc. Dans la pratique, il reste encore beaucoup d’étapes à franchir avant que des Zones Villageoises d’Intérêt Cynégétique (ZOVIC) réellement autonomes et indépendantes financièrement ne prennent corps. Les résistances au niveau institutionnel et privé ne manquent pas, et seule la démonstration de la capacité des populations locales à relever ce défi pourra faire évoluer les mentalités. Les premières ZOVIC ont été mises en place à partir de 2000 dans les périphéries du Ranch de Nazinga (1 276 ha de ZOVIC) et du Parc du W (1 790 ha de ZOVIC). Ces expériences ont été la source de riches enseignements dans des contextes particuliers de tensions foncières, liés soit à une importante immigration humaine dans le cas de la ZOVIC du Ranch de Nazinga, soit à une course au coton dans celui des ZOVIC du Parc du W. Elles ont montré que la gestion cynégétique villageoise nécessitait des besoins de formation importants et qu’elle devait faire face aux classiques enjeux techniques (préservation de l’habitat, gestion de la faune, quotas d’abattage dont l’application reste parfois aléatoire en raison de la petite taille des zones délimitées, etc.). Les ZOVIC ont aussi soulevé le problème du rapport de la communauté rurale à l’espace et au foncier, celui fonctionnement des structures locales de gestion et de leur fusion avec le système politique coutumier local, et celui de la réelle volonté de l’univers administratif et privé de la chasse à partager la rente cynégétique avec les populations locales. La gestion cynégétique villageoise doit donc être comprise comme un exercice de démocratie directe et comme la voie vers la gestion globale des terroirs villageois. Au-delà de l’aspect technique lié à la faune et à sa gestion durable, la réussite de ces expériences devrait également annoncer la pratique d’une chasse plus sociale et plus équitable, où les populations locales participeraient davantage au partage du flux financier. [less ▲]

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See detailL'etude clinique du mois. INTERHEART": la preuve par 9. Neuf facteurs de risque predisent neuf infarctus du myocarde sur dix."
Scheen, André ULiege; Kulbertus, Henri ULiege

in Revue Médicale de Liège (2004), 59(11), 676-9

INTERHEART is a standardised case-control study of acute myocardial infarction in 52 countries representing every inhabited continent. 15152 cases and 14820 controls were enrolled. Collectively, 9 factors ... [more ▼]

INTERHEART is a standardised case-control study of acute myocardial infarction in 52 countries representing every inhabited continent. 15152 cases and 14820 controls were enrolled. Collectively, 9 factors accounted for 90% of myocardial infarctions in men and 94% in women. These factors were 6 risk factors (dyslipidaemia characterized by high apoB/apoA1 ratio, smoking, hypertension, diabetes mellitus, abdominal obesity and stressful psychosocial factors) and 3 protective factors (daily consumption of fruits and vegetables, regular alcohol consumption, and regular physical activity). These findings suggest that interventions targeting these 9 factors have the potential to prevent most premature cases of myocardial infarction and that these strategies should be implemented worldwide. [less ▲]

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See detailAngioplastie percutanee coronaire chez le patient diabetique. Partie 3: Nouvelles perspectives apportees par les stents enrobes.
Warzee, Fabian ULiege; Legrand, Victor ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(12), 711-6

Coronary revascularization procedures are associated with less favourable outcomes in diabetic patients as compared to non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is ... [more ▼]

Coronary revascularization procedures are associated with less favourable outcomes in diabetic patients as compared to non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is associated with a high level of restenosis and recurrent cardiac morbidity and mortality. In diabetic patients, PTCA should ideally be combined with stents. Bare-metal stents reduce by almost half the risk of restenosis, but this favourable effect decreases with the vessel calibre, a common finding in diabetic patients. Drug-eluting stents containing pharmacological agents that can reduce the risk of restenosis (sirolimus, paclitaxel) provide better angiographic results, including in small coronary arteries, and this effect has been shown to be accompanied by significant reduction of both morbidity and mortality. Such preliminary results obtained in the general population (including around 20% of diabetic subjects) deserve further confirmation in a large clinical trial specifically devoted to diabetic patients. Drug-eluting stents may represent a major advance in the management of diabetic patients with coronary heart disease in the near future. [less ▲]

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See detailUne matrice conceptuelle de la négociation. Du marchandage à la négociation valorielle
Kuty, Olgierd ULiege

in Négociations (2004), 1(1), 45-62

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See detailPlurilinguisme hybride et méthodes d’apprentissage de la lecture
Lucchini, Silvia ULiege

in Dialogues et Cultures (2004), 49

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