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See detailPolyolefin-based composites by polymerization-filling technique
Dubois, Philippe ULg; Alexandre, Michaël ULg; Hindryckx, François et al

in Journal of Macromolecular Science - Reviews in Macromolecular Chemistry and Physics (1998), 38(3), 511-565

Dispersions of inorganic fillers within polymers are commonly designated as polymer-based composites. The properties of these materials are isotropic or anisotropic, depending on the geometry of the ... [more ▼]

Dispersions of inorganic fillers within polymers are commonly designated as polymer-based composites. The properties of these materials are isotropic or anisotropic, depending on the geometry of the filler particles and the effect of the processing conditions on their orientation. Fillers are used to improve some physicomechanical properties of the polymer, the material processability, or decrease the final cost. As a typical example, highly filled composites in which the filler concentration approaches the maximum packing fraction are known for their use in the shaping of ceramic articles. [less ▲]

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See detailCleavase Fragment Length Polymorphism (Cflp): A Methodology To Further Exploit Polymorphisms From Pcr Products Of Plastid Dna (Ptdna) In Phaseolus
Fofana, B.; Martiat, Jc.; Baudoin, Jean-Pierre ULg et al

in Plant Molecular Biology Reporter (1998), 16(3),

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See detailSuperconducting properties of natural and artificial grain boundaries in bulk melt-textured YBCO
Vanderbemden, Philippe ULg; Bradley, A. D.; Doyle, R. A. et al

in Physica C: Superconductivity (1998), 302(4), 257-270

A range of experimental techniques have been used to characterize melt-processed YBa2Cu3O7-d samples containing single-grain boundaries. Both natural high-angle boundaries, which sometimes appear during ... [more ▼]

A range of experimental techniques have been used to characterize melt-processed YBa2Cu3O7-d samples containing single-grain boundaries. Both natural high-angle boundaries, which sometimes appear during the grain growth process, and artificial low-angle boundaries, obtained by joining two single domains, have been investigated. Electrical resistivity, current-voltage characteristics, magnetic moment measurements and Hall probe mapping techniques have been employed to investigate the boundaries. Results are compared with the properties of single domain material (i.e., containing no grain boundary) for which T-c approximate to 89 K and J(c)parallel to ab (77 K, 1 T) > 10^4 A/cm(2). Resistance measurements across all the grain boundaries show a stronger dependence on current and magnetic field than that measured within the grains and exhibit a pronounced resistive 'tail'. The I-V curves obtained for the high-angle natural grain boundary are sharp and differ from the rounded I-V curves which are characteristic of single-grains. Field mapping measurements used to evaluate the critical current anisotropy are in agreement with magnetisation measurements. The limitations of this technique for investigating boundaries are discussed. It was found that current anisotropy can conceal a weak link between two grains, leading to a false indication of single-grain behaviour. Artificially engineered boundaries are shown to have significant potential for applications in high fields at 77 K. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailThe Current N-15-Leucine Infusion Technique Is Not Suitable For Quantitative Measurements Of Ileal Endogenous Amino Acid Flows In Pigs
Leterme, Pascal; Seve, Bernard; Thewis, André ULg

in Journal of Nutrition (1998), 128(11), 1961-1968

The current 15N-leucine infusion technique may overestimate the ileal endogenous nitrogen losses in pigs. To determine the reason, we infused four cannulated pigs intravenously, fed them a pea-based diet ... [more ▼]

The current 15N-leucine infusion technique may overestimate the ileal endogenous nitrogen losses in pigs. To determine the reason, we infused four cannulated pigs intravenously, fed them a pea-based diet with 15N-leucine, and examined some methodological variables. Neither the blood sampling time nor the choice of precursor pool (total N or amino acid N of deproteinized plasma) or the method of estimation of the isotopic equilibrium level significantly affected the results. On the other hand, the 15N-enrichment of purified mucin, isolated from ileal digesta, was higher than that of the plasma amino acid pool (0.114 vs. 0.077 atom % excess). The endogenous proportion of the labeled amino acids (Ala, Gly, Ile, Leu and Val) in the ileal digesta ranged from 23 (Leu) to 74% (Ala), compared with 70% for total N. The low value of leucine was ascribed to the constant marker infusion condition. In pigs infused with 13C-leucine, a similar endogenous proportion was obtained for lumenal leucine with 13C-leucine and 15N-leucine infusion. However, the 13C-enrichment of the leucine bound to mucin was markedly lower than that of plasma leucine (38%). The endogenous amino acid flows were also estimated by combining the ileal N flow measured with 15N and the endogenous amino acid profile obtained by means of an N-free diet. They were different from those obtained with the 15N-amino acid dilution technique. We conclude that the precursor pool currently used (plasma total N or total a-amino acid N pools) is a poor indicator of the enrichment of the secretions and that the infusion of one labeled amino acid is not sufficient to extend the method at the amino acid level. [less ▲]

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See detailScale relativity and quantization of the solar system - Orbit quantization of the planet's satellites
Hermann, Raphaël ULg; Schumacher, G.; Guyard, R.

in Astronomy and Astrophysics (1998), 335(1), 281-286

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present ... [more ▼]

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present paper we show that one more class of objects of the solar system satisfy the rule of quantization, this class including the main satellites and rings of the outer planets. We also give a classification of the satellites by rank, showing that one can predict the existence of certain orbits that are not occupied, or whose objects are not yet discovered. [less ▲]

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See detailThe Pathophysiology of Migraine: A Review Based on the Literature and on Personal Contributions
Schoenen, Jean ULg

in Functional Neurology (1998), 13(1, Jan-Mar), 7-15

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See detailA pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family.
Charlier, Carole ULg; Singh, N. A.; Ryan, S. G. et al

in Nature Genetics (1998), 18(1), 53-5

Epileptic disorders affect about 20-40 million people worldwide, and 40% of these are idiopathic generalized epilepsies (IGEs; ref. 1). Most of the IGEs that are inherited are complex, multigenic diseases ... [more ▼]

Epileptic disorders affect about 20-40 million people worldwide, and 40% of these are idiopathic generalized epilepsies (IGEs; ref. 1). Most of the IGEs that are inherited are complex, multigenic diseases. To address basic mechanisms for epilepsies, we have focused on one well-defined class of IGEs with an autosomal-dominant mode of inheritance: the benign familial neonatal convulsions (BFNC; refs 2,3). Genetic heterogeneity of BFNC has been observed. Two loci, EBN1 and EBN2, have been mapped by linkage analysis to chromosome 20q13 (refs 5,6) and chromosome 8q24 (refs 7,8), respectively. By positional cloning, we recently identified the gene for EBN1 as KCNQ2 (ref. 9). This gene, a voltage-gated potassium channel, based on homology, is a member of the KQT-like family. Here we describe an additional member, KCNQ3. We mapped this new gene to chromosome 8, between markers D8S256 and D8S284 on a radiation hybrid map. We screened KCNQ3 for mutations in the large BFNC family previously linked to chromosome 8q24 in the same marker interval. We found a missense mutation in the critical pore region in perfect co-segregation with the BFNC phenotype. The same conserved amino acid is also mutated in KVLQT1 (KCNQ1) in an LQT patient. KCNQ2, KCNQ3 and undiscovered genes of the same family of K+ channels are strong candidates for other IGEs. [less ▲]

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See detailAminoglycoside 6 '-N-Acetyltransferase Variants Of The Ib Type With Altered Substrate Profile In Clinical Isolates Of Enterobacter Cloacae And Citrobacter Freundii
Casin, I.; Bordon, F.; Bertin, P. et al

in Antimicrobial Agents and Chemotherapy (1998), 42(2), 209-15

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6'-N acetyltransferase type II [AAC(6 ... [more ▼]

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6'-N acetyltransferase type II [AAC(6')-II] production, which conferred reduced susceptibility to gentamicin but not to amikacin or isepamicin. Aminoglycoside acetyltransferase assays suggested the synthesis in the three strains of an AAC(6') which acetylated amikacin practically as well as it acetylated gentamicin in vitro. Both compounds, however, as well as isepamicin, retained good bactericidal activity against the three strains. The aac genes were borne by conjugative plasmids (pLMM562 and pLMM564 of ca. 100 kb and pLMM563 of ca. 20 kb). By PCR mapping and nucleotide sequence analysis, an aac(6')-Ib gene was found in each strain upstream of an ant(3")-I gene in a sulI-type integron. The size of the AAC(6')-Ib variant encoded by pLMM562 and pLMM564, AAC(6')-Ib7, was deduced to be 184 (or 177) amino acids long, whereas in pLMM563 a 21-bp duplication allowing the recruitment of a start codon resulted in the translation of a variant, AAC(6')-Ib8, of 196 amino acids, in agreement with size estimates obtained by Western blot analysis. Both variants had at position 119 a serine instead of the leucine typical for the AAC(6')-Ib variants conferring resistance to amikacin. By using methods that predict the secondary structure, these two amino acids appear to condition an alpha-helical structure within a putative aminoglycoside binding domain of AAC(6')-Ib variants. [less ▲]

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See detailInduction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury.
Hopkins, D. A.; Plumier, Jean-Christophe ULg; Currie, R. W.

in Experimental Neurology (1998), 153(2), 173-83

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular ... [more ▼]

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular metabolic stress. In this study, we examined the distribution of Hsp27 in the rat medulla oblongata by means of immunohistochemistry after the vagus nerve was cut or crushed. After vagal injury, rats were allowed to survive for 6, 12, 24 h, 2, 4, 7, 10, 14, 30, or 90 days. Vagus nerve lesions resulted in a time-dependent up-regulation of Hsp27 in vagal motor and nodose ganglion sensory neurons that expressed Hsp27 constitutively and de novo induction in neurons that did not express Hsp27 constitutively. In the dorsal motor nucleus of the vagus nerve (DMV) and nucleus ambiguus, the levels of Hsp27 in motor neurons were elevated within 24 h of injury and persisted for up to 90 days. Vagal afferents to the nucleus of the tractus solitarius (NTS) and area postrema showed increases in Hsp27 levels within 4 days that were still present 90 days postinjury. In addition, increases in Hsp27 staining of axons in the NTS and DMV suggest that vagus nerve injury resulted in sprouting of afferent axons and spread into areas of the dorsal vagal complex not normally innervated by the vagus. Our observations are consistent with the possibility that Hsp27 plays a role in long-term survival of distinct subpopulations of injured vagal motor and sensory neurons. [less ▲]

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See detailImproved IL-2 detection for determination of helper T lymphocyte precursor frequency in limiting dilution assay
Winandy, Marie ULg; Lewalle, Philippe; Deneys, Véronique et al

in Journal of Immunological Methods (1998), 215

In the context of allogeneic bone marrow transplantation, an accurate estimate of the risk of developing graft-versus-host disease GVHD. is of major interest. The pre-transplant frequency of donor’s ... [more ▼]

In the context of allogeneic bone marrow transplantation, an accurate estimate of the risk of developing graft-versus-host disease GVHD. is of major interest. The pre-transplant frequency of donor’s helper T-lymphocyte precursors HTLp. directed against host’s antigens may be helpful in predicting this risk. This technique relies on an indirect measurement of interleukin-2 IL-2. secreted by the HTLp, as assessed by the proliferation of an IL-2 dependent cell line. Many authors use the murine CTLL-2 cell line in this assay, but these cells do not respond to the presence of minute amounts of IL-2 in the culture medium, and thus do not discriminate between the absence or the presence of very low levels of IL-2. We therefore decided to compare CTLL-2 with another IL-2 dependent cell line, the murine A9.12 cell line. A comparison was made using serial dilutions of recombinant human IL-2, limiting dilutions of baby hamster kidney BHK. cells transfected with human IL-2 gene and in the context of clinical tests performed for the detection of pre-transplant HTLp. Both the sensitivity and reliability of the tests were better using A9.12. We conclude that the A9.12 cell line might be a more suitable tool for pre-transplant HTLp determinations before allogeneic bone marrow transplantation or whenever low IL-2 levels are to be measured. [less ▲]

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See detailGrandir en l'an 2000 : les enfants et l'école maternelle
Crahay, Marcel ULg; Hindryckx, Geneviève ULg; Lafontaine, Annette ULg et al

in Point sur la Recherche en Education (Le) (1998), 6

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See detailConservative Mutations In The Immunosuppressive Region Of The Bovine Leukemia Virus Transmembrane Protein Affect Fusion But Not Infectivity In Vivo
GATOT, Jean-Stéphane ULg; Callebaut, I.; Mornon, Jp. et al

in Journal of Biological Chemistry (1998), 273(21),

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See detailNouveaux traitements immunomodulateurs dans la maladie de Crohn
Louis, Edouard ULg; Belaiche, Jacques ULg

in Médecine et Hygiène (1998), 56

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See detailLatinitas-Peregrinitas. Purisme et nationalisme linguistique chez les grammairiens latins
Rochette, Bruno ULg

in Orbis : Bulletin international de documentation linguistique (1998), 40

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See detailVariations in systemic and pulmonary endothelin-1 in horses with recurrent airway obstruction (heaves)
Benamou, A. E.; Art, Tatiana ULg; Marlin, D. J. et al

in Pulmonary Pharmacology & Therapeutics (1998), 11

Recurrent airway obstruction (RAO) is an asthma-like condition of the horse that represents a major cause of morbidity and loss of performance. The exact pathogenesis of asthma in man is unclear but the ... [more ▼]

Recurrent airway obstruction (RAO) is an asthma-like condition of the horse that represents a major cause of morbidity and loss of performance. The exact pathogenesis of asthma in man is unclear but the role of endothelin (ET) is currently under investigation, thus sparking interest in the bronchoconstrictive and vasoconstrictive properties of endothelin in the equine-specific disease entity. In this study, we investigated the levels of ET-1 in systemic blood, as well as in bronchoalveolar lavage (BAL) from horses with RAO. We also studied how these values might correlate with those of lung function tests and pulmonary artery pressure. Five horses with RAO were evaluated both in remission and in crisis and compared to five control horses. RAO horses had significantly (P<0.05) higher systemic ET-1 levels than control horses. They also had a negative arteriovenous ET-1 difference that may correspond to a net uptake of ET-1 in the lung. RAO horses in crisis had increased amounts of immunoreactive ET in BAL fluid compared to normal control subjects. Additionally, the reduction in lung function seen in RAO horses in crisis was significantly correlated with lower epithelial lining fluid ET-1 levels. Our results demonstrate that endothelin may contribute to the pathogenesis of asthma. [less ▲]

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See detailPd-Ag/SiO2 sol-gel catalysts designed for selective conversion of chlorinated alkanes into alkenes
Heinrichs, Benoît ULg; Delhez, Patrice; Schoebrechts, Jean-Paul et al

in Studies in Surface Science and Catalysis (1998), 118

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See detailPharma-clinics. Le medicament du mois. L'atorvastatine (Lipitor).
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(6), 374-7

Atorvastatin, commercialized by the pharmaceutical companies Parke-Davis and Pfizer under the trade name Lipitor, is a new statin acting as a potent hypolipidaemic drug. By inhibiting HMG-CoA reductase ... [more ▼]

Atorvastatin, commercialized by the pharmaceutical companies Parke-Davis and Pfizer under the trade name Lipitor, is a new statin acting as a potent hypolipidaemic drug. By inhibiting HMG-CoA reductase, the key-enzyme of cellular synthesis of cholesterol, it increases the expression of LDL receptors and promotes the hepatic extraction of circulating LDL. It has a more potent action than other available statins, both on LDL cholesterol and triglyceride levels. Atorvastatin is indicated, after diet failure, in the treatment of primary hypercholesterolaemia or combined hyperlipidaemia. Lipitor is available as tablets of 10 and 20 mg. The usual doses is 10 mg once a day, to be increased up to 20 mg/day if necessary. In rare severe cases, the doses may be increased up to 80 mg/day. [less ▲]

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See detailOral taurine supplementation modulates ethanol-conditioned stimulus preference
Quertemont, Etienne ULg; Goffaux, Valérie; Vlaminck, Anne-Michèle et al

in Alcohol (1998), 16(3), 201-206

The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor ... [more ▼]

The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor stimulus was daily paired with either ethanol (0.3 or 2.0 g/kg) or saline. In addition, half of the rats were supplemented orally with taurine (0.5 g/kg/day). After eight conditioning sessions, all rats were tested for their vinegar stimulus preference or aversion. In nontaurine-treated rats, 2.0 g/kg ethanol conditioning induced a significant aversion for the vinegar stimulus, while there was no preference after 0.3 g/kg ethanol conditioning. However, in taurine-supplemented rats, the 2.0 g/kg ethanol-induced aversion for the stimulus was decreased significantly, while the rats administered the lower ethanol doses, 0.3 g/kg, in combination with taurine supplementation, demonstrated a significant stimulus preference. Such results suggest that taurine modulates some of the aversive or rewarding effects of ethanol. [less ▲]

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See detailUn revenant au Faubourg Saint-Léonard à Liège en 1634
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (1998), t.XIII, n° 283

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See detailGrazing incidence X-ray reflectometry studies of CdTe(1 1 1) surfaces and a-Si thin films
Ijdiyaou, I.; Hafidi, K.; Azizan, M. et al

in Solar Energy Materials & Solar Cells (1998), 52

Chemically treated cadmium telluride (CdTe) surfaces and amorphous silicon (a-Si) thin films were characterized by X-ray reflectometry at grazing incidence. In the case of the surface of CdTe single ... [more ▼]

Chemically treated cadmium telluride (CdTe) surfaces and amorphous silicon (a-Si) thin films were characterized by X-ray reflectometry at grazing incidence. In the case of the surface of CdTe single crystal treated with an oxidizing agent (a solution of Br2 in CH3OH), the superficial layer was found to be less dense than its support with a profound alteration of CdTe in the volume. After rinsing in KOH solution, the properties of single-crystalline CdTe are obtained. In the case of a-Si thin layers, we show that the simulation of the reflectometry curves enables not only the determination of the layer thickness but also the detection of an ultrathin superficial oxide layer. [less ▲]

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See detailLes aires protégées dans la tourmente. Evolution de la situation de 1990 à 1996
Bouché, Philippe ULg

in Cahiers d'Ethologie (1998), 18(2), 161-174

The Akagera National Park (ANP) and the Volcano National Park (VNP) are the main protected areas in Rwanda. Following civil war that bloodstained the country since 1990, the destiny of these two parks ... [more ▼]

The Akagera National Park (ANP) and the Volcano National Park (VNP) are the main protected areas in Rwanda. Following civil war that bloodstained the country since 1990, the destiny of these two parks diverged. The VNP, dedicated to the conservation of one of the last population of mountain gorillas and of their habitat, recovered somehow the same situation as before the war despite some gorillas were lost. The ANP, on the other hand, has been invaded by large herds of domestic cattle, which resulted in serious injuries at its integrity. It seems that two-thirds of the park are on the way to be sacrificed and will be devoted to human and cattle settlement. The fate of the remaining third is still undecided. About 63 years after the park was created, the golden era of this protected area of international reputation seems close to an end... But it is the conservationists' duty to carry on. [less ▲]

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See detailLaser-assisted dielectronic recombination in C4+ ions
Bachau, H.; Gayet, R.; Lambropoulos, P. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1998), 31(14), 3263-3280

We study the effect of laser-driven transitions between autoionizing resonances on the dielectronic recombination rates observed after the formation of such resonances in electron-ion collisions. The ... [more ▼]

We study the effect of laser-driven transitions between autoionizing resonances on the dielectronic recombination rates observed after the formation of such resonances in electron-ion collisions. The autoionizing states of S-1(e) and P-1(0) symmetry belonging to the 2l2l' and 2l3l' configurations of C4+ are considered. The resonance parameters are calculated in the Feshbach formalism and compared with other accurate calculations, and transition dipole moments between the autoionizing states are obtained. The rates of dielectronic recombination and autoionization under the influence of the laser field are calculated using the density matrix approach for realistic parameters. A simple formulation of the problem is also proposed in the resolvent operator technique. The feasibility of an experiment is discussed. [less ▲]

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See detailSynthesis of Tetraalkyl(Pyrrolidine-2,2-diyl)bisphosphonates and 2,2-Bis(diethoxyphosphoryl)-3,4-dihydro-2H-pyrrole 1-Oxide; ESR Study of Derived Nitroxides
Olive, Gilles ULg; Le Moigne, François; Mercier, Anne et al

in Journal of Organic Chemistry (1998), 63(24), 9095-9099

Synthesis of Tetraalkyl (Pyrrolidine-2,2-diyl)bisphosphonates and 2,2-Bis(diethoxyphosphoryl)-3,4-dihydro-2Hpyrrole 1-Oxide; ESR Study of Derived Nitroxides

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See detailInfluence de facteurs abiotiques ou biotiques sur l'evaluation de la sensibilite d'Aphidius rhopalosiphi De Stefani-Perez a la phosalone.
Guelton, O.; Deleu, R.; Schiffers, Bruno ULg et al

in Parasitica (1998), 54(2-3),

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des ... [more ▼]

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des céréales. L'influence de l'humidité relative, de la photo période, du mode de conservation des momies ainsi que du sexe des insectes sur la sensibilité des parasitoïdes à la phosalone a été étudiée. L'humidité relative influence le plus la sensibilité des insectes lors des essais, le mode de conservation des momies se révèle important lui aussi. [less ▲]

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See detailA Qtl with Major Effect on Milk Yield and Composition Maps to Bovine Chromosome 14
Coppieters, Wouter ULg; Riquet, J.; Arranz, J. J. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1998), 9(7), 540-4

A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of ... [more ▼]

A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of a locus on the centromeric end of bovine Chromosome (Chr) 14, with major effect on fat and protein percentage as well as milk yield. The genuine nature of this QTL was verified using the grand2-daughter design, that is, by tracing the segregating QTL alleles from heterozygous grandsires to their maternal grandsons and confirming the predicted QTL allele substitution effect. [less ▲]

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See detailLa succession des régions aux obligations aquiliennes de l'Etat relatives à la voirie
Delnoy, Michel ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

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See detailMolecular Definition of an Allelic Series of Mutations Disrupting the Myostatin Function and Causing Double-Muscling in Cattle
Grobet, Luc ULg; Poncelet, D.; Royo, L. J. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1998), 9(3), 210-3

We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be ... [more ▼]

We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous or compound heterozygotes for one of the five loss-of-function mutations. The absence of obvious loss-of-function mutations in the coding sequence of the two remaining breeds points either towards additional mutations in unexplored segments of the gene, or towards locus heterogeneity of double-muscling. [less ▲]

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See detailL'analyse en composantes principales : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1998), (2), 1-31

This note describes the principles of principal component analysis and gives two examples.

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See detailChorologie et écologie de Pycnoporus Cinnabarinus (Polyporaceae) en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes
Thoen, Daniel ULg; Fraiture, A.; Nicolas, Jacques ULg

in Belgian Journal of Botany (1998), 131(2), 260-272

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de ... [more ▼]

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de distribution. La propagation du champignon semble s'être effectuée à deux "vitesses" : par bonds, sur des distances de plusieurs dizaines de kilomètres, et de proche en proche, au départ de populations voisines. L'analyse de la fréquence et de la fréquence cumulée des récoltes montre deux grandes "vagues" successives d'expansion du champignon. La liste des arbres hôtes est établie ainsi que la fréquence relative du champignon en fonction des hôtes. Les hôtes les plus fréquents sont les bouleaux (Betula alba et Betula pendula), le hêtre (Fagus sylvatica), le sorbier des oiseleurs (Sorbus aucuparia) et les chênes (Quercus robur et Quercus petraea). Les causes de l'extension et des fluctuations des populations du champignon ne sont pas connues avec certitude. Il semble cependant que des facteurs climatiques et le fait que de plus grandes quantités de bois pourrissant soient abandonnées sur les coupes puissent être impliqués. [less ▲]

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See detailCalcium binding protein calcyphosin in dog central astrocytes and ependymal cells and in peripheral neurons
Halleux, P.; Schurmans, Stéphane ULg; Schiffmann, S. N. et al

in Journal of Chemical Neuroanatomy (1998), 15

Calcyphosine is a calcium binding protein discovered in the dog thyroid in 1979. Calcyphosine mRNA and immunoreactivity were detected using Western and Northern blotting in the cerebral cortex, cerebral ... [more ▼]

Calcyphosine is a calcium binding protein discovered in the dog thyroid in 1979. Calcyphosine mRNA and immunoreactivity were detected using Western and Northern blotting in the cerebral cortex, cerebral white matter and cerebellum. Using immunohistochemistry and in situ hybridization, both are present in ependymal cells, choroid plexus cells and several types of astrocytes of the subependymal cerebral layer, the cerebellar Bergmann layer, the retinal ganglion cell layer, the optic nerve and the posterior pituitary. Both are also present in neurons of nasal olfactory mucosa, enteric Auerbach and Meissner plexuses, orthosympathic and spinal cord ganglia as well as in endocrine cells of neural crest origin in the adrenal medulla. Calcyphosine immunoreactive astrocytes were also present mainly in hemispheric cerebral gray and white matter, hemispheric subcortical structures, brain stem and spinal cord. These results show that calcyphosine is a characteristic calcium binding protein of astrocytes and ependymal cells in the central nervous system and of neurons in the peripheral nervous system. This is of interest in view of the importance of calcium regulation in these cells, and since calcyphosine a calcium binding protein phosphorylated by cAMP dependent process, may be an intermediate between cAMP and inositol phosphate cascades [less ▲]

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See detailLes goûts et les odeurs, ça peut se discuter.
Blecker, Christophe ULg; Willem, Georges

in Probio (1998), (4), 289-315

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See detailL'erytheme necrolytique migrateur.
Dandrifosse, J. F.; Dandrifosse, A. C.; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1998), 53(12), 778-83

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to ... [more ▼]

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to glucagonoma treatments, the administration of corticoids, aminoacids, zinc or essential fatty acids can be helpful. There exist several etiological hypotheses for NME. These are based on modifications of pancreatic enzyme activities and on variations of aminoacids, fatty acids, zinc or glucagon concentrations. [less ▲]

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See detailFeeding in darkness alleviates density-dependent growth of juvenile vundu catfish Heterobranchus longifilis (Clariidae)
Baras, E.; Tissier, F.; Westerloppe, L. et al

in Aquatic Living Resources (1998), 11

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See detailZolmitriptan, a 5-HT1B/1D receptor agonist for the acute oral treatment of migraine: a multicentre, dose-range finding study.
Dahlof, C.; Diener, H. C.; Goadsby, P. J. et al

in European Journal of Neurology (1998), 5(6), 535-543

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral ... [more ▼]

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral zolmitriptan (5, 10, 15 and 20 mg) in the treatment of single acute migraine attacks. Of 1181 patients randomized, 840 were evaluable for the primary efficacy analysis. Headache response rates (a reduction in headache intensity from severe or moderate at baseline to mild or no pain at 2 hours post-treatment) were similar across the zolmitriptan dose groups (66%, 71%, 69% and 77% for 5 mg, 10 mg, 15 mg and 20 mg, respectively) and were significantly higher than that for placebo (19%; all groups P < 0.001). A headache response was reported at 1 hour by 40-50% of zolmitriptan recipients (16% placebo). At 2 hours post dose, 39-47% of zolmitriptan-treated patients were pain-free, compared with 1% of placebo recipients. Headache recurrence occurred in 21-29% (upper 95% CI 37.1) of zolmitriptan-treated patients and in 65% (95% CI 38.3, 85.8) of placebo recipients. Zolmitriptan was well tolerated at each dose. The most commonly reported adverse events were asthenia, dizziness, paraesthesia and feelings of heaviness. Most adverse events were of mild or moderate intensity and were transient. The frequency of adverse events was dose-related. Although, zolmitriptan 5 mg exhibited the most favourable efficacy and tolerability profile, the dose response data suggest that lower doses would also offer significant efficacy. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

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See detailRadial tree-growth modelling with fuzzy regression.
Boreux, Jean-Jacques ULg; Gadbin-Henry, C.; Guiot, Joël et al

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (1998), 28(8), 1249-1260

A so-called fuzzy linear regression is used in dendroecology to model empirically tree growth as a function of a bioclimatic index representing the water stress, i.e., the ratio of actual ... [more ▼]

A so-called fuzzy linear regression is used in dendroecology to model empirically tree growth as a function of a bioclimatic index representing the water stress, i.e., the ratio of actual evapotranspiration to potential evapotranspiration. The response function predicts tree growth as (fuzzy) intervals, narrow in the domain where the bioclimatic index is most limiting and becoming progressively larger elsewhere. The method is tested with a population of Pinus pineaL. from the Provence region in France. It is shown that fuzzy linear regression gives results comparable with those obtained using a linear response function. The interval of credibility given by the fuzzy regression suggests that more precise expected growth is obtained for high water stress, which is typical of Mediterranean climate. Fuzzy linear regression can be also a method to test different hypotheses on several potential predictors when any further experimental approach is quite impossible as it is for trees in their natural environment. To sum up, fuzzy regression could be a first step before the construction of a kind of growth simulator adapted to different environments of a given species. In environmental sciences, the fuzzy response function thus appears to be an approach between the mechanistic and the statistical descriptive approaches. [less ▲]

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See detailPharma-clinics. Le medicament du mois. Le formoterol (Oxis Turbohaler).
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(11), 715-8

Formoterol, commercialized by Astra under the trade name Oxis, is a new potent and selective agonist of beta-2 adrenergic receptors, which is used with a specific device (Turbohaler) allowing effective ... [more ▼]

Formoterol, commercialized by Astra under the trade name Oxis, is a new potent and selective agonist of beta-2 adrenergic receptors, which is used with a specific device (Turbohaler) allowing effective inhalation. Bronchodilatation occurs rapidly, within 1-3 minutes after inhalation, and lasts about 12 hours after the administration of a unique dose. Oxis Turbohaler is indicated to reduce symptoms associated with bronchial obstruction in asthmatic patients when the control of asthma is not achieved with inhaled corticoid therapy. It is not indicated for the treatment of acute crisis. It is presented as powder vials for inhalation (4.5 or 9 micrograms per dose). The usual dose in adults is 1-2 inhalations 1-2 times per day, in the morning and/or in the evening (bedtime administration should be recommended in case of nocturnal asthma). There is not enough data for treating children. The lowest dose allowing adequate control of asthma should be selected for chronic treatment. [less ▲]

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See detailApproach to the use of immobilizer sulfatase for analytical purposes and for the pràoduction of desulfo-glucosinolates
Wathelet, Jean-Paul ULg

in Industrial Crops & Products (1998), 7

A commercial crude sulfatase from snail (Helix pomatia) was purified by ion exchange affinity, HPLC, gel-filtration chromatography. The enzyme isolated. which was ca. 37-folcl more active than the ... [more ▼]

A commercial crude sulfatase from snail (Helix pomatia) was purified by ion exchange affinity, HPLC, gel-filtration chromatography. The enzyme isolated. which was ca. 37-folcl more active than the commercial one was covalently immobilizcd on nyon 6.6 by the cross linking method. Immobilized sulfatase was usecl to produce some desulfo-glucosinolates (DSGLs) on the gram-scale. starting fiom glucotropaeolin. glucoraphenin ancl épiprogoitrin ancl for HPLC analyses of glucosinolates (GLs) containecl in cruciferous material and rapeseecl in particular. The immobilized enzyme as well as allowing the standarclization of the HPLC methocl for GLs analysis seems to be an efflcient system for producing DSGLs which are interesting starting materials to prepare bio-active structures through further chemical modilications. [less ▲]

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See detailInfluence Of The Mode Of Insertion Of Siv Peptides Into Membranes On The Structure Of Model Membrane As Studied By P-31 Nmr
Schanck, A.; Peuvot, J.; Brasseur, Robert ULg

in Biochemical and Biophysical Research Communications (1998), 250(1), 12-4

The influence on model membrane organization of a fusion peptide of SIV and of a nonfusogenic mutant of this peptide was examined by molecular modeling and by 31P NMR. The calculated mode of insertion of ... [more ▼]

The influence on model membrane organization of a fusion peptide of SIV and of a nonfusogenic mutant of this peptide was examined by molecular modeling and by 31P NMR. The calculated mode of insertion of the fusion peptide shows that it adopts an oblique orientation towards the lipid-water interface and that this fusion peptide induces a destabilization of the bilayer structure of multilamellar vesicles as evidenced by 31P NMR observations. The SIV mutant showing a more vertical insertion into lipid layers is unable to induce nonlamellar structures. This study reinforces the correlation between fusogenic activity, induction of structures not organized in extended bilayers, and calculated mode of insertion of peptides into lipid layers. [less ▲]

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See detailClinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure.
Eisele, Bernd; Lamy, Maurice ULg

in Seminars in Thrombosis & Hemostasis (1998), 24(1), 71-80

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years ... [more ▼]

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years and still comes to 35% to 45%. For quite a long time our understanding of the pathophysiology of sepsis was mainly focused on endotoxin and proinflammatory cytokines like tumor necrosis factor or interleukin-1. Now it is generally accepted that many signs and symptoms of sepsis are not directly mediated by cytokines but are transmitted through other mediator systems. The coagulation system comes into play especially when the septic process progresses to malperfusion and organ failure. Antithrombin III is an important inhibitor of the intrinsic, extrinsic and common pathway of coagulation. Recently, evidence has been accumulating that there is an additional anti-inflammatory potential of the drug. Currently there are several clinical trials ongoing to investigate whether this effect is of clinical relevance in the treatment of patients with severe sepsis. [less ▲]

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See detailRandomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study.
Bertrand, M. E.; Legrand, Victor ULg; Boland, J. et al

in Circulation (1998), 98(16), 1597-603

BACKGROUND: Dual therapy with ticlopidine and aspirin has been shown to be as effective as or more effective than conventional anticoagulation in patients with an optimal result after implantation of ... [more ▼]

BACKGROUND: Dual therapy with ticlopidine and aspirin has been shown to be as effective as or more effective than conventional anticoagulation in patients with an optimal result after implantation of intracoronary metallic stents. However, the safety and efficacy of antiplatelet therapy alone in an unselected population has not been evaluated. METHODS: Patients were randomized to conventional anticoagulation or to treatment with antiplatelet therapy alone. Indications for stenting were classified as elective (decided before the procedure) or unplanned (to salvage failed angioplasty or to optimize the results of balloon angioplasty). After stenting, patients received aspirin and either ticlopidine or conventional anticoagulation (heparin or oral anticoagulant). The primary end point was the occurrence of bleeding or peripheral vascular complications; secondary end points were cardiac events (death, infarction, or stent occlusion) and duration of hospitalization. RESULTS: In 13 centers, 236 patients were randomized to anticoagulation and 249 to antiplatelet therapy. Stenting was elective in 58% of patients and unplanned in 42%. Stent implantation was successfully achieved in 99% of patients. A primary end point occurred in 33 patients (13.5%) in the antiplatelet group and 48 patients (21%) in the anticoagulation group (odds ratio=0.6 [95% CI 0.36 to 0.98], P=0.03). Major cardiac-related events in electively stented patients were less common (odds ratio=0.23 [95% CI 0.05 to 0.91], P=0.01) in the antiplatelet group (3 of 123, 2.4%) than the anticoagulation group (11 of 111, 9.9%). Hospital stay was significantly shorter in the antiplatelet group (4.3+/-3.6 versus 6. 4+/-3.7 days, P=0.0001). CONCLUSIONS: Antiplatelet therapy after coronary stenting significantly reduced rates of bleeding and subacute stent occlusion compared with conventional anticoagulation. [less ▲]

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See detailAnalytical solution of a simple artificial lighting scheme to test any lighting software
Embrechts, Jean-Jacques ULg

in Computer Modeling & Simulation in Engineering (1998), 3(3)

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See detailGyalideopsis cochlearifer, a new pantropical, commensalistic species on foliicolous Gomphillaceae
Lücking, Robert; Sérusiaux, Emmanuël ULg

in Lichenologist (1998), 30

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See detailOiseau, d'où viens-tu?
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (1998), 31(8), 20-22

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See detailJean le Lydien, Caton, Varron et Servius
Rochette, Bruno ULg

in Byzantinische Zeitschrift (1998), 91(2), 471-474

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See detailTheoretical Study of the 4f146s2S1/2 - 4f136s22F°7/2E3 transition in Yb II
Biémont, Emile ULg; Quinet, Pascal ULg

in Physical Review Letters (1998), 81

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See detailTrophic relationships within intertidal communities of the Brittany coast: a stable carbon isotope analysis
Dauby, Patrick ULg; Khomsi, Ahmid; Bouquegneau, Jean-Marie ULg

in Journal of Coastal Research (1998), 14

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See detailDu théâtre et de la politique selon Jean-Marie Piemme
Delhalle, Nancy ULg

in Alternatives Théâtrales (1998)

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See detailInfo-congres. Les lecons de la "United Kingdom Prospective Diabetes Study".
Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (1998), 53(9), 576-8

The United Kingdom Prospective Diabetes Study (UKPDS) is the largest study ever performed in the field of diabetes. It has been carried on in more than 5000 patients with newly diagnosed type 2 diabetes ... [more ▼]

The United Kingdom Prospective Diabetes Study (UKPDS) is the largest study ever performed in the field of diabetes. It has been carried on in more than 5000 patients with newly diagnosed type 2 diabetes and followed during almost 15 years. The main goals of the study were to investigate the effects of improving blood glucose and/or blood pressure control on diabetic complications, and to compare the advantages and inconvenients of the most important pharmacological approaches. The results of the UKPDS have been presented at the last Congress of the European Association for the Study of Diabetes (EASD) in Barcelona, September 10-11, 1998. They essentially showed that improving blood glucose or arterial blood pressure control allows to significantly reduce the incidence of complications associated to diabetes. Best results were observed in individuals in whom treatments of both hyperglycemia and hypertension were intensified. For each risk factor, no threshold has been found so that every reduction in blood glucose or arterial pressure is accompanied by a nearly linear diminution in the incidence of diabetic complications. The type of pharmacological treatment appears to have a less prominent influence, even if metformin appears to exert the most favourable effects in the group of obese patients with type 2 diabetes. [less ▲]

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See detailLes thiazolidinediones : quel avenir dans le traitement du diabète de type 2 ?
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (1998), 56

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See detailL1-protein in incipient lymphocyte-depleted graft-versus-host disease. Expression in keratinocytes and coexpression with Factor XIIIa in dermal cells
Pierard, Gérald ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Turkish Journal of Dermatology = Dermatopatoloji Dergisi (1998), 7

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated ... [more ▼]

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated cutaneous graft-versus-host reaction (GVHR) where the most straightful histologic clue was the epidermal L1-protein (calprotectin) expression revealed by a positive immunolabelling using the Mac 387 antibody. The epidermis looked otherwise normal and inflammatory cells were scant in the dermis. The expression of calprotectin by keratinocytes occurred early in cutaneous GVHR. In addition, CD45RO-positive T memory lymphocytes were exceedingly rare in the dermis while a few Mac 387-positive monocytes coexpressed Factor XIIIa immunoreactivity. Hyperplasia of the Factor XIIIa-positive dendrocytic population was obvious. Calprotectin and Factor XIIIa immunolagellings should be regarded as a diagnostic adjunct in lymphocyte-depleted cutaneous GVHR. Calprotectin positivity of the epidermis is indicative although not specific for such condition. However, its combination with a low lymphocytes/monocytes ratio in the dermis which is enriched in plup dendrocytes is almost diagnostic. [less ▲]

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See detailLe cal habitue de betterave sucriere : Deviations metaboliques et cancerisation
Le Dily, F.; Kevers, Claire ULg; Huault, C. et al

in Bulletin de la Societe Royale des Sciences de Liege (1998), 67(3-4), 165-176

[No abstract available]

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See detailSanté et environnement : analogies dans les approches sociologiques
Mougenot, Catherine ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(2), 96-105

Ce texte repose sur l'idée qu'il peut exister bon nombre d'homologies entre les questions de recherche en sciences sociales sur la santé et sur l'environnement. On cherchera à donner corps à cette ... [more ▼]

Ce texte repose sur l'idée qu'il peut exister bon nombre d'homologies entre les questions de recherche en sciences sociales sur la santé et sur l'environnement. On cherchera à donner corps à cette intuition sur base d'une recension récente de textes portant sur la santé, en les présentant à partir de trois thématiques non totalement dispointes. La santé et l'environnement reposent largement sur des représentations collectives qui, même si elles restent floues, n'en sont pas moins efficaces, socialement. Une seconde thématique concerne la prévention, tout aussi essentielle en matière de santé que d'environnement. Enfin, force est de constater que dans ces deux domaines, la place de la science et le rôle des scientifiques sont incontournables. Comment peut-on les caractériser ? C'est ce que cherchent à accompagner des notions récentes en sociologie. [less ▲]

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See detailProtein composition and agglomeration tendency of gluten isolated from European wheats (Triticum aestivum L.) in a batter system
Roels, S. P.; Sindic, Marianne ULg; Deroanne, Claude et al

in Journal of Agricultural and Food Chemistry (1998), 46(4), 1344-1349

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons ... [more ▼]

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons) resulted in, on average, gluten yields of 9.6% (4.7-13.2% range). Gluten protein recoveries averaged 63.0% (34.5-85.7% range). Gluten yields and gluten protein recoveries were linearly related and increased when mixing times and baking absorptions required for optimal dough development of the parent flours increased, indicating that there is a relationship between the agglomeration properties of gluten proteins in a batter system and the optimal technological conditions necessary for processing the flours in breadmaking. The Osborne protein fractions in the gluten fractions were determined. The 0.05 M acetic acid soluble (glutenin) fraction was quantitatively the most important fraction (40-46% of gluten Kjeldahl nitrogen) while comparable levels of 70% ethanol soluble (gliadins) and 0.05 M acetic acid insoluble (residue protein) were found (17.9-22.3% of gluten Kjeldahl nitrogen and 22.0-29.0% of gluten Kjeldahl nitrogen for gliadins and residue protein, respectively). With decreasing pore size of the sieves, the level of glutenin in the gluten decreased while the level of gliadins increased. This indicates that, in gluten with good agglomeration properties, the level of glutenins is high and that the agglomeration properties of such proteins (i.e. their tendency to aggregate) strongly determines the agglomeration behavior of the gluten as a whole. [less ▲]

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See detailWorking memory deficits in Alzheimer's disease
Collette, Fabienne ULg; Van der Linden, Martial ULg; Bechet, Sophie ULg et al

in Brain and Cognition (1998), 37(1), 147-149

The phonological loop and central executive components of working memory were examined in patients with Alzheimer's disease (AD patients) and elderly controls. Patients with Alzheimer's disease showed ... [more ▼]

The phonological loop and central executive components of working memory were examined in patients with Alzheimer's disease (AD patients) and elderly controls. Patients with Alzheimer's disease showed reduced verbal spans, with smaller phonological similarity and word length effects. They also showed a decreased performance in tasks examining processing speed and articulation rate. However, phonological analysis was normal. With regard to the central executive, AD patients showed deficits in an alphabetical span task in which subjects were asked to recall a random series of words in their alphabetical order, while they performed normally on a dual task in which they had to perform simultaneously a digit repetition and a visuomotor task. These results suggests that Alzheimer's disease may affect several components of working memory but all aspects of the central executive mechanism are not necessarily affected. [less ▲]

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See detailPrenatal diagnosis of pyruvate carboxylase defiency by direct measurement of catalytic activity on chorionic villi samples
Van Coster; Janssens, S.; Misson, Jean-Paul ULg et al

in Prenatal Diagnosis (1998), 18

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See detailInsulin-like growth factor-I (IGF-I), IGF-binding proteins synthesis, and thyroid status are affected by dexamethasone esters treatment in finishing calves
Bertozzi, Carlo; Massart, Serge; Prandi, Alberto et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 45

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See detailLe monticule frasnien de la carrière du Nord à Frasnes (Belgique): sédimentologie, stratigraphie séquentielle et coraux
Boulvain, Frédéric ULg; Coen-Aubert, M.

in Professional Paper Belgian Geological Survey (1998), 285

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See detailEtudes des fibres alimentaires chez le chien : présentation des résultats de sept essais expérimentaux
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1998), 142(3), 185-201

The present paper presents the results and conclusions of 7 trials made in healthy (6 studies) and obese (1 study) dogs to experiment the effects of dietary fibre on faeces characteristics, nutrients ... [more ▼]

The present paper presents the results and conclusions of 7 trials made in healthy (6 studies) and obese (1 study) dogs to experiment the effects of dietary fibre on faeces characteristics, nutrients digestibility, water consumption and plasma metabolites. Several incorporation rates of different fibre sources (cellulose, guar gum, inulin, fructooligosaccharides (FOS), pectins, beet fibre, beet pulp and chicory pulp) were studied. Furthermore, a blend of cellulose and guar gum was formulated to imitate the ratio of soluble-to-insoluble fibre of beet fibre to study the influence of the fibre solubility. Drinking water consumption was increased by beet fibre and inulin in the diet. With the exception of cellulose for dry matter (DM) concentration, the different fibres induced similar effects on faeces: increased daily excretion, decreased DM concentration and increased excretion of DM. Nutrient digestibility coefficients were diversely affected by fibre consumption and, excepted for the ether extract, decreased in nutrients digestibility were in relation with added total or insoluble fibre in the diet. Important metabolic effects were observed but were not in relation with the solubility of the fibre. Decreased pre- and/or postprandial plasmatic concentrations of glucose (with FOS), insulin (with guar gum), urea, cholesterol (with guar gum) and triglycerides (with FOS) suggest that most of the studied fibres should be used as an aid for dogs suffering from obesity, diabetes mellitus, hyperlipaemia, chronic renal insufficiency or constipation. [less ▲]

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See detailCumulation and injury determination of the European Community in antidumping cases
Tharakan, P. K. M.; Greenaway, David; Tharakan, Joseph ULg

in Weltwirtschaftliches Archiv (1998)

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See detailX-ray studies of enzymes that interact with penicillins.
Kelly, J. A.; Kuzin, A. P.; Charlier, Paulette ULg et al

in Cellular and Molecular Life Sciences : CMLS (1998), 54(4), 353-8

The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic ... [more ▼]

The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and beta-lactamases. An insight into the structural basis for antibiotic resistance is given. [less ▲]

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See detailEarly clinical experience with subcutaneous naratriptan in the acute treatment of migraine: a dose-ranging study.
Dahlof, C.; Hogenhuis, L.; Olesen, J. et al

in European Journal of Neurology (1998), 5(5), 469-477

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to ... [more ▼]

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to evaluate the efficacy, safety and tolerability of five doses of subcutaneous (sc) naratriptan (0.5, 1, 2.5, 5 or 10 mg) in comparison with sc sumatriptan (6 mg) and placebo in the acute treatment of a moderate/severe migraine attack. Headache relief [reduction of headache severity from moderate or severe (grade 2/3) to mild or none (grade 1/0)] at 1 and 2 h after each dose, was reported by a statistically significantly higher proportion of patients for all doses of sc naratriptan and sc sumatriptan (6 mg) than for placebo. The percentages of patients with headache relief at 2 h post-dose were: naratriptan (0.5 mg) 65%, (1 mg) 75%, (2.5 mg) 83%, (5 mg) 94% and (10 mg) 91%; sumatriptan (6 mg) 89%; placebo 41%, (P < 0.005). The earliest report of a statistically significant difference compared with placebo for the times assessed was with sc naratriptan (10 mg) at 10 min post-dose (P = 0.023). The percentages of patients reporting adverse events were dose-related; sc naratriptan (0.5 mg) 33%, (1 mg) 29%, (2.5 mg) 43%, (5 mg) 59% and (10 mg) 71%; sc sumatriptan 53%; placebo 22%. There were no clinically significant changes in electrocardiogram (ECG), vital signs or laboratory parameters. Systemic exposure increased proportionally to the dose, the absorption of sc naratriptan was rapid (tmax = 10 min) and the half-life was 5 h. In conclusion, sc naratriptan was an effective and well-tolerated acute treatment for migraine. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

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See detailThymic expression of neuroendocrine self-peptide precursors: role in T-cell survival and self-tolerance
Geenen, Vincent ULg; Kecha, Ouafae; Martens, Henri ULg

in Journal of Neuroendocrinology (1998), 10

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See detailOccupation et utilisation du sol récentes en Région wallonne : analyses et synthèses
Schmitz, Serge ULg; Christians, Charles ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1998), 1

The first part is an analytical study based on an analysis of cadastral information. It presents facts and recent evolutionary processes of land use in Wallonia, especially agriculture, forest, waste land ... [more ▼]

The first part is an analytical study based on an analysis of cadastral information. It presents facts and recent evolutionary processes of land use in Wallonia, especially agriculture, forest, waste land and urbanized areas. The information is based on the municipality scale. The paper draws a compartmentalization of Wallonia: in 1992, urbanized areas represented over 20% and 40% in the urban-industrial trench and in Walloon Brabant, spilling area for Brussels population. In Ardennes, Loraine and Fagne Famenne, Forest prevailed occupying over 40% of the land. Agriculture was the main land used over 70% on low loess plateaux and with over 55% especially in Condroz and Central Ardennes. There was a slow decrease of agriculture between 1982 and 1992, usually with less than 10% for a third of the region. Forest erratically fluctuated between -5% and +5%. On the contrary urbanized areas grew everywhere with peaks around Liege, in Walloon Brabant and along motorways. It was the result of both residential urbanization and the standard increase of land use per inhabitant. The analysis shows that, during the seventies, peaks of urbanization coincide quite well with demographic evolution typology. The second part is a continuation of the preceding analytical study. It presents typology and evolution synthesis in order to divide Wallonia into districts and analyses some mechanics especially urbanization and land policy. The analytical maps lead to the building up of two types of municipalities: urban and country land use municipalities. Within the country type, five subtypes have been characterized upon the agriculture and forest combinations. Urbanization mechanics are responsible for the schematic division into two parts by a line, the south border of Condroz and Herve plateau. Urbanization concerns first the urban-industrial trench and Walloon Brabant. Hainaut is an forests also divide Wallonia between the north and the south. The agricultural areas are first victims of the urbanization progress. [less ▲]

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See detailQuelle place pour l'isocinétisme dans la rééducation de l'épaule?
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg

in Lettre de Médecine Physique et de Réadaptation (1998), 48

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See detailDoes an Acute COPD Crisis Modify the Cardiorespiratory and Ventilatory Adjustments to Exercise in Horses?
Art, Tatiana ULg; Duvivier, Dominique Hannia; Votion, Dominique ULg et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1998), 84(3), 845-52

The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD ... [more ▼]

The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD horses were submitted to a standardized submaximal treadmill exercise test while they were in clinical remission or in acute crisis. Respiratory airflow, O2 and CO2 fractions in the respired gas, pleural pressure changes and heart rate were recorded, and arterial and mixed venous blood were analyzed for gas tensions, hemoglobin, and plasma lactate concentrations. O2 consumption, CO2 production, expired minute ventilation, tidal volume, alveolar ventilation, cardiac output, total pulmonary resistance, and mechanical work of breathing were calculated. The results showed that, when submaximally exercised, COPD horses in crisis were significantly more hypoxemic and hypercapnic and that their total pulmonary resistance and mechanical work of breathing were significantly higher and their expired minute ventilation significantly lower than when they were in remission. However, their O2 consumption remained unchanged, which was probably due to the occurrence of compensatory mechanisms, i.e., higher heart rate, cardiac output, and hemoglobin concentration. Last, their net anaerobic metabolism seemed to be more important. [less ▲]

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See detailDelayed-onset profound biotinidase deficiency.
Wolf, B.; Pomponio, R. J.; Norrgard, K. J. et al

in The Journal of pediatrics (1998), 132(2), 362-5

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb ... [more ▼]

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb weakness, spastic paresis, and eye problems, such as loss of visual acuity and scotomata, rather than the more characteristic symptoms observed in young untreated children with the disorder. These older children each have different mutations, but they are the same as those of children who have exhibited symptoms at an early age. Biotinidase deficiency should be considered in older children who suddenly experience limb weakness and/or spastic paresis and eye symptoms. [less ▲]

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See detailGrowth hormone binding protein (GHBP) during lactation in cows
Renaville, Robert ULg; Prandi, Alberto; Massart, Serge et al

in Archivio Veterinario Italiano (1998), 48

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See detailEffect of Ketoprofen on Paf-Induced Bovine Platelet Aggregation
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Journal (1998), 155(2), 201-203

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See detailFunctional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family
Poncelet, Dominique A.; Bellefroid, Eric J.; Bastiaens, P. V. et al

in DNA & Cell Biology (1998), 17(11), 931-43

We previously identified the ZNF85 (HPF4) KRAB zinc finger gene, a member of the human ZNF91 family. Here, we show that the ZNF85 gene is highly expressed in normal adult testis, in seminomas, and in the ... [more ▼]

We previously identified the ZNF85 (HPF4) KRAB zinc finger gene, a member of the human ZNF91 family. Here, we show that the ZNF85 gene is highly expressed in normal adult testis, in seminomas, and in the NT2/D1 teratocarcinoma cell line. Immunocytochemical localization of a panel of beta-Gal/ZNF85 fusion proteins revealed that ZNF85 contains at least one nuclear localization signal located in the spacer region connecting the KRAB domain with the zinc finger repeats. Bacterially expressed ZNF85 zinc finger domain bound strongly and exclusively to DNA in vitro in a zinc-dependent manner. The KRAB(A) domain of the ZNF85 protein and of several other members of the ZNF91 family exhibited repressing activity when tested in Gal4 fusion protein assays. The repression was significantly enhanced by the addition of the KRAB (B) domain, whereas further addition of other conserved regions had no effect. The ZNF85 KRAB(A) and (B) domains in vitro bound several nuclear proteins that might constitute critical cofactors for repression. [less ▲]

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See detailMadeline Gins' Helen Keller or Arakawa
Delville, Michel ULg

in The Germ: A Journal of Poetic Research (1998), 2

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See detailTopology Optimization of Continuum Structures with Local Stress Constraints
Duysinx, Pierre ULg; Bendsoe, Martin Philip

in International Journal for Numerical Methods in Engineering (1998), 43

We introduce an extension of current technologies for topology optimization of continuum structures which allows for treating local stress criteria. We rst consider relevant stress criteria for porous ... [more ▼]

We introduce an extension of current technologies for topology optimization of continuum structures which allows for treating local stress criteria. We rst consider relevant stress criteria for porous composite materials, initially by studying the stress states of the so-called rank 2 layered materials. Then, on the basis of the theoretical study of the rank 2 microstructures, we propose an empirical model which extends the power penalized sti ness model (also called SIMP for Solid Isotropic Microstructure with Penalization for intermediate densities). In a second part, solution aspects of topology problems are considered. To deal with the so-called 'singularity' phenomenon of stress constraints in topology design, an -constraint relaxation of the stress constraints is used. We describe the mathematical programming approach that is used to solve the numerical optimization problems, and show results for a number of example applications. [less ▲]

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See detailA lichenological excursion in May 1997 near Han-sur-Lesse and Saint-Hubert, with notes on rare or critical taxa of the flora of Belgium and Luxembourg
van den Boom, Pieter; Sérusiaux, Emmanuël ULg; Diederich, Paul et al

in Lejeunia, Revue de Botanique (1998), 158

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See detailInterictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices.
Afra, Judit; Mascia, Adolores; GERARD, Pascale ULg et al

in Annals of Neurology (1998), 44(2), 209-15

We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks ... [more ▼]

We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks. By using a 13-cm circular coil placed over the vertex and recordings of the first dorsal interosseus muscle, we measured thresholds (at rest and during contraction), amplitudes of motor evoked potentials and cortical silent periods. Paired stimulations with short (1-20 msec) interstimulus intervals were performed to assess intracortical inhibition. The visual cortex was stimulated with the same coil placed over the occipital scalp (7 cm above the inion) and the prevalence and threshold of phosphene production was determined. In patients with migraine with aura, motor thresholds during isometric contraction were significantly higher, whereas the prevalence of stimulation-induced phosphene production was lower compared with healthy controls. These changes were not correlated with attack frequency or disease duration. No differences were found between subject groups in thresholds at rest, motor evoked potential amplitudes, cortical silent periods, or response curves after paired stimuli. These results are in favor of cortical hypoexcitability rather than hyperexcitability in patients with migraine with aura between attacks. [less ▲]

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See detailUse of a variable incidence angle PIXE arrangement for studying pigment multilayers
Weber, Georges ULg; Delbrouck, J. M.; Strivay, David ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (1998), 139(1-4), 196-201

Particle induced X-ray emission (PIXE) method is used in the field of archeometry and specially to investigate pigment colored multilayers. The tilting of the sample with respect to the incident proton ... [more ▼]

Particle induced X-ray emission (PIXE) method is used in the field of archeometry and specially to investigate pigment colored multilayers. The tilting of the sample with respect to the incident proton beam direction allows to modify the relative contribution of each layer to the fluorescence signal. The experimental results coupled to computer simulations lead to semi-quantitative information about the thickness, the position and the composition of the successive layers. (C) 1998 Elsevier Science B.V. [less ▲]

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See detailLes enjeux des revendications en matière de moeurs
Jacobs, Ann ULg

in Journal des procès (1998), (345), 22

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See detailUne nouvelle tentative de commentaire de la strophe Yt 5. 7
Swennen, Philippe ULg

in Studia Iranica (1998), 27(2), 205-212

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See detailCalretinin expression as a critical component in the control of dentate gyrus long-term potentiation in mice
Gurden, H.; Schiffmann, S. N.; Lemaire, M. et al

in European Journal of Neuroscience (1998), 10

We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc ... [more ▼]

We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415 ). Here, we investigated dentate LTP induction in mice heterozygous (Cr+/–) for the same mutation. Despite the presence of calretinin in neurons of these mice, although at reduced levels as compared with normal mice, LTP induction in dentate gyrus was totally impaired. Spatial memory and learning were found unaffected in Cr+/– mice, such as in Cr–/– mice. Altogether, our results suggest that calretinin is a critical component in the control of dentate synaptic plasticity in mice, and that levels of calretinin higher than those observed in Cr+/– mice are required to induce LTP in this area. The possible mechanisms leading to the absence of correlation between gene dosage and biological effects are discussed [less ▲]

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See detailAspects genetiques du male 46, XX.
Marquet, F.; Beckers, Albert ULg; Verloes, Alain ULg

in Revue Médicale de Liège (1998), 53(12), 738-740

The XX males represent a proportion of 1/25 of all patients suffering of the Klinefelter syndrome. From a clinical and endocrinological point of view, they exhibit a hypogonadotropic hypogonadism ... [more ▼]

The XX males represent a proportion of 1/25 of all patients suffering of the Klinefelter syndrome. From a clinical and endocrinological point of view, they exhibit a hypogonadotropic hypogonadism. Isolated cases are rare and familial forms are exceptional. The XX males may be divided in 3 subgroups: 46, XX males with the SRY gene; 46, XX males without the SRY gene and XX/XY mosaics. [less ▲]

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See detailDynamic Jahn-Teller interaction with Gamma(5) phonons in the ground state of Cu2+ in cubic II-VI semiconductors
Colignon, David ULg; Mailleux, Éric; Kartheuser, Eduard ULg et al

in Physical Review. B : Condensed Matter (1998), 57(20), 12932-12938

Optical absorption and emission measurements of Cu2+ as a substitutional impurity in cubic ZnS and ZnTe rue analyzed by means of an electron-phonon coupling model. The D-2 term of Cu2+ is split by a ... [more ▼]

Optical absorption and emission measurements of Cu2+ as a substitutional impurity in cubic ZnS and ZnTe rue analyzed by means of an electron-phonon coupling model. The D-2 term of Cu2+ is split by a crystal field of tetrahedral symmetry into a (2) Gamma(5) orbital triplet and a (2) Gamma(3) orbital doublet. Optical transitions have been observed between these two multiplets in ZnS:Cu2+ and within the (2) Gamma(5) ground state in ZnTe:Cu2+. The theoretical model is based on crystal-field theory and includes the spin-orbit interaction and a dynamic Jahn-Teller interaction between the electronic (2) Gamma(5) states and a transverse acoustic phonon of TI symmetry. Starting from the ten spin-orbit wave functions appropriate to the orbital tripler and doubler manifolds, the symmetry-adapted vibronic basis is constructed and used to diagonalize the Hamiltonian matrix. Phonon overtones up to n = 14 are included to ensure convergence of the energy eigenvalues. The measured positions and relative intensities of the spectral lines are described with good accuracy by the theoretical model, including covalency effects.. In ZnS, comparison between theory and experiment yields the following values of the physical parameters: the crystal-field splitting Delta = 5990.6 cm(-1), the spin-orbit coupling constants lambda(1) = -667 cm(-1) and lambda(2) = -830 cm(-1), the phonon energy h omega = 73.5 cm(-1), and the Jahn-Teller stabilization energy E-JT = 474.5 cm(-1) The corresponding parameters in ZnTe are Delta = 6000 cm(-1), lambda(1) = -888 cm(-1), lambda(2)= -830 cm(-1), h omega= 38.8 cm(-1), and E-JT= 468.5 cm(-1). [less ▲]

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See detailLes antagonistes des récepteurs de l'angiotensine II
Krzesinski, Jean-Marie ULg

in Vaisseaux, Coeur, Poumons (1998), 3(4), 116-119

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See detailhyperfractionated accelerated radiotherapy (HART) immediately followed by surgery in locally advanced rectal cancer (LARC)
Coucke, Philippe ULg; Bouzourenne, Hanifa; Zouhair, Abderrahim et al

in Radiotherapy & Oncology (1998), 48(Supp1), 73

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See detailLes mecanismes responsables de la resistance aux insecticides chez les insectes et les acariens.
Haubruge, Eric ULg; Amichot, M.

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(3),

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See detailToxiques et analyses biologiques en toxicologie hospitalière
Capolaghi, B.; Charlier, Corinne ULg; Feuillu, A. et al

in Toxicorama (1998), X

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See detailHydrolysis Of The Dimethyl Ester Of N-Succinylphenylalanine, A Model Of Polyesteramides, In The Presence Of Papain - Kinetic Study And Computer Simulation
David, C.; Lefèbvre, F.; Brasseur, Robert ULg et al

in Enzymes In Polymer Synthesis (1998), 684

Our work is concerned with the kinetics of enzymatic hydrolysis of substrates containing ester and amide groups and with the interactions between the active site of the enzyme and the function to be ... [more ▼]

Our work is concerned with the kinetics of enzymatic hydrolysis of substrates containing ester and amide groups and with the interactions between the active site of the enzyme and the function to be hydrolyzed, special attention is paid to differences between a soluble substrate which can fit the active site and a crystalline or semi-crystalline substrate. [less ▲]

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See detailPulmonary function and pain after gastroplasty performed via laparotomy or laparoscopy in morbidly obese patients.
Joris, Jean ULg; Hinque, V. L.; Laurent, P. E. et al

in British Journal of Anaesthesia (1998), 80(3), 283-8

We have compared severely obese patients (body mass index > 35 kg m-2) undergoing laparoscopic or open gastroplasty (n = 15 in each group) to determine if laparoscopy results in any benefit in the obese ... [more ▼]

We have compared severely obese patients (body mass index > 35 kg m-2) undergoing laparoscopic or open gastroplasty (n = 15 in each group) to determine if laparoscopy results in any benefit in the obese. Postoperative pain, measured on a 100-mm visual analogue scale, and opioid consumption were recorded during the first two days after operation. Tests of pulmonary function were performed and SpO2 was measured 4 h after surgery and on days 1, 2 and 3 after operation. Pain at rest was similar in the two groups, but in the laparoscopy group, requirements for postoperative opioid were 50% less (P < 0.05). Pain intensity during mobilization and on coughing was significantly less after laparoscopy (differences between mean pain scores in both groups ranged from 20 to 32 mm during mobilization and from 32 to 34 mm during coughing). Forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow rate were reduced significantly less after laparoscopic gastroplasty than after open gastroplasty (on day 1 forced vital capacity was reduced by 50% compared with 64%, forced expiratory volume in 1 s was reduced by 50% compared with 66% and peak expiratory flow rate by 45% compared with 60%). SpO2 values were significantly greater in the laparoscopy group (day 1: mean 95 (SD 2)% vs 91 (5)%; day 3: 97 (1)% vs 94 (3)%). This study suggests that the beneficial effects observed after laparoscopic gastroplasty in morbidly obese patients were similar to those reported after laparoscopic cholecystectomy in non-obese patients. [less ▲]

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See detailEstimation of the dominance variance for postweaning gain in the US Limousin population
Gengler, Nicolas ULg; Misztal, I.; Bertrand, J. K. et al

in Journal of Animal Science (1998), 76(10), 2515-2520

The objective of this study was to estimate the dominance variance for postweaning gain in Limousin cattle. Data included 215,326 records of postweaning gain from 205 to 365 d, provided by the North ... [more ▼]

The objective of this study was to estimate the dominance variance for postweaning gain in Limousin cattle. Data included 215,326 records of postweaning gain from 205 to 365 d, provided by the North American Limousin Foundation. Parental dominance subclasses were formed and related using the method of Hoeschele and VanRaden. Variance components were estimated using Method R based on six samples of 50%. Fixed effects in the model included contemporary group apd covariates for inbreeding and breed composition (percentage Limousin). Heterozygosity was negatively correlated with breed composition (< -.99) and was therefore not included in the model. Two types of contemporary groups used as original groups from the National Cattle Evaluation were partially based on breed composition. Original contemporary groups that were too homogeneous for breed composition were replaced by herd-year-sex classes. Two models were used with the two data sets. Model 1 contained the fixed effects described above and an additive genetic effect. Model 2 Included a dominance effect in addition to the effects contained in Model 1. In total, four combinations of contemporary group x model were used. Dominance variance was computed as being four times the estimated parental subclass variance. Estimates for inbreeding depression and breed composition (percentage Limousin) were all small and not greatly affected by inclusion of dominance effects or changes in contemporary groups. Estimates of the additive variance (expressed as percentage of the phenotypic variance) were only slightly affected, with values between 20 and 21%. Dominance estimates were highly affected when passing from original (10%) and to alternative contemporary groups (18%). Such large values may indicate that dominance is important for postweaning gain. Results showed the advantage of an individual dominance approach based on sire-dam combinations; therefore, expected gains through the use of specific combination ability as a part of the mating selection criteria for growth might be high. [less ▲]

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See detail"Dans la langue de nos pères"
Rochette, Bruno ULg

in Byzantion : Revue Internationale des Etudes Byzantines (1998), 68

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See detailTarifs de cubage et paramètres de forme. L'aulne glutineux.
Rondeux, Jacques ULg; Lejeune, Philippe ULg; Thibaut, André et al

in Silva Belgica (1998), 105(6), 7-12

Dans le cadre de cette recherche dont l'un des objectifs finaux est la construction de modèles de croissance, une première étape a été consacrée à l'établissement de tarifs de cubage d'arbres appropriés à ... [more ▼]

Dans le cadre de cette recherche dont l'un des objectifs finaux est la construction de modèles de croissance, une première étape a été consacrée à l'établissement de tarifs de cubage d'arbres appropriés à l'aulne glutineux et à la région de croissance étudiée. Cette démarche était d'autant plus utile que très peu de travaux dendrométriques sont disponibles pour cette essence en Europe. [less ▲]

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See detailPharma-Clinics. Essais cliniques medicamenteux: importance et role du medecin generaliste .
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(1), 17-20

Clinical trials are an essential step in the development of a drug. They must be conducted according to strict rules called "Good Clinical Practice" or GCP. GCP requirements aim to guarantee a perfect ... [more ▼]

Clinical trials are an essential step in the development of a drug. They must be conducted according to strict rules called "Good Clinical Practice" or GCP. GCP requirements aim to guarantee a perfect methodology in the planning, realization and interpretation of clinical trials. The latter can be divided in four phases: phase 1 aiming to demonstrate the safety and to investigate the pharmacokinetics/metabolism of the drug in healthy volunteers; phase 2 aiming to study the intrinsic activity (generally versus a placebo) and safety of the compound in a rather small number of (hospitalized) patients; phase 3 aiming to confirm the comparative efficacy (versus a placebo or a reference drug) and safety of the pharmacological agent in a quite large number of (ambulatory) patients; and phase 4 carried out after commercialization, to verify the clinical utility of the drug in conditions of daily practice. Because he/she occupies a crucial position in the recruitment and follow-up of outpatients, the general practitioner should play a more active role in clinical trials, provided that he/she could work in collaboration with academic centers specialized in clinical pharmacology which can help to perform studies in accordance with GCP requirements. [less ▲]

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See detailSample size for collecting seeds in germplasm conservation: the case of the Lima bean (Phaseolus lunatus L.)
Bi, Irié Zoro; Maquet, A.; Degreef, J. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1998), 97(1-2),

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See detailAspects de la gestion de clubs de football belges francophones. Comparaison en fonction du niveau de jeu
Cloes, Marc ULg; Chapelle, Jean-yves; Ledent, Maryse et al

in AES Magazine (1998), 52

Dans la société occidentale actuelle, les loisirs occupent une part extrêmement importante dans le style de vie de la majorité des individus. Bien que les loisirs soient caractérisés par une très grande ... [more ▼]

Dans la société occidentale actuelle, les loisirs occupent une part extrêmement importante dans le style de vie de la majorité des individus. Bien que les loisirs soient caractérisés par une très grande diversité, le sport figure parmi les activités qui y sont le plus fréquemment associés. Au fil des ans, le sport a pris de plus en plus d'importance, non seulement au point de vue de nombre de personnes concernées mais également au point de vue de l'implication financière qui résulte de sa pratique. ... [less ▲]

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