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See detailVegetation mapping: from patch to planet (R. Alexander, A.C. Millington).
Bogaert, Jan ULiege

in Landscape & Urban Planning (2003), 64

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See detailDownregulation of putative tumor suppressor gene TSC-22 in human brain tumors.
Shostak, Kateryna ULiege; Dmitrenko, Vladimir V.; Garifulin, Oleg M. et al

in Journal of Surgical Oncology (2003), 82(1), 57-64

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and ... [more ▼]

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and human postnatal brain cDNA libraries was performed by differential hybridization with glioblastoma multiforme and human normal brain cDNAs. RESULTS: Repeated differential hybridization of more than 100 cDNA clones selected by primary screening and analysis of RNA from adult normal brain and glial tumors showed 16 nucleotide sequences differentially expressed between normal brain and brain tumors. Among others, decreased content in astrocytic tumors was determined for TSC-22 mRNA corresponding to cDNA in the ICRFp507J1041 clone from human fetal brain cDNA library. Northern blot hybridization of RNA from different human brain tumors showed very low amounts of TSC-22 mRNA in most investigated samples of GBM, anaplastic astrocytoma, and some other tumors. Complete lack of expression of TSC-22 occurred in one sample of anaplastic astrocytoma, as well as in meningioma, brain sarcoma, sarcomatous meningioma, and oligodendroglioma. The differential expression of TSC-22 gene was confirmed by semiquantitative RT-PCR in 15 samples of astrocytomas WHO grade II-IV and three samples of normal brain. CONCLUSIONS: Significantly decreased levels of TSC-22 mRNA in human brain and salivary gland tumors and antiproliferative role of TSC-22 strongly suggest a tumor suppressor role for TSC-22. J. [less ▲]

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See detailRealization of electroplating molds with thick positive SPR 220-7 photoresist
Kukharenka, Elena; Kraft, Michael ULiege

in Journal of Materials Science: Materials in Electronics (2003), 14(5-7), 319--322

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See detailRadiothérapie métabolique des douleurs osseuses métastatiques
Hustinx, Roland ULiege; Sautois, Brieuc ULiege; Jerusalem, Guy ULiege et al

in Médecine et Hygiène (2003), 61

La radiothérapie métabolique des métastases osseuses est un traitement palliatif de la douleur. Cet objectif est rempli dans la grande majorité des cas, sans effets secondaires cliniquement ressentis par ... [more ▼]

La radiothérapie métabolique des métastases osseuses est un traitement palliatif de la douleur. Cet objectif est rempli dans la grande majorité des cas, sans effets secondaires cliniquement ressentis par le patient. Tous les patients en dissémination osseuse ne peuvent cependant bénéficier de cette approche qui, lorsqu'elle est choisie, doit toujours être appliquée dans un cadre multidisciplinaire. Les lésions accessibles à ce traitement doivent avoir démontré leur caractère ostéocondensant en scintigraphie. La fonction rénale et la réserve médullaire sont des paramètres importants, l'élimination des radiopharmaceutiques étant urinaire et leur toxicité, médullaire. Les situations particulières telles que risque fracturaire important ou compression médullaire sont des contre-indications. Le traitement est simple dans son principe et dans sa réalisation. Il permet une amélioration très significative de la qualité de vie, tout en réalisant des économies substantielles en terme de coût de santé publique. [less ▲]

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See detailLes ateliers du Matériel: pivots de la diffusion de l'organisation rationnelle au sein de la Société Nationale des Chemins de fer Belges, 1910-1940
Geerkens, Eric ULiege

in Revue d'Histoire des Chemins de Fer (2003), (28-29), 207-221

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d ... [more ▼]

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d'expérimentation, le point de diffusion de ces méthodes vers d'autres services de la société, mais aussi vers les constructeurs belges de matériel roulant. L'introduction du système de rémunération Rowan à l'atelier central de Malines (principal atelier du matériel du réseau belge) peut être tenu pour le point de départ de l'adoption de méthodes d'organisation rationnelle, dans la mesure où elle impliquait une première forme d'étude systématique du travail ouvrier. Au lendemain de la Première Guerre, une nouvelle organisation du travail d'inspiration taylorienne et son corollaire indispensable - une comptabilité industrielle - vont être introduits dans les ateliers de moyenne réparation des locomotives. Associée initialement à une concentration des ateliers, la taylorisation ne va cesser de progresser. L'adoption du travail à la chaîne pour le placement de freins à air sur ses wagons a constitué une des innovations majeures dans l'organisation du travail à la SNCB. Forte de cette expérience, la SNCB va étendre le travail à la chaîne à d'autres travaux exécutés par le service du Matériel, puis à certaines activités d'autres services. Ainsi cette technique, adoptée pour une opération ponctuelle, va être appliquée aux travaux récurrents de réparation et d'entretien du matériel roulant. Au service de l'Exploitation, la recherche d'un équilibre optimal entre les tâches successives, déterminant majeur du rendement dans le travail à la chaîne, va fournir le principe d'une organisation nouvelle du triage des wagons; de même, les travaux d'entretien des voies vont être réorganisés de manière à les faire exécuter suivant certains principes du travail à la chaîne. La baisse du trafic de marchandises et la dégradation de ses résultats financiers au début des années '30 vont amener la SNCB à approfondir la rationalisation des différents travaux, par une combinaison de techniques déjà éprouvées et de procédures nouvelles; la gestion très centralisée des ateliers va s'appuyer sur deux techniques particulières: les plannings et le contrôle budgétaire. Par une modification de ses principes d'adjudication, la société va aussi imposer le travail à la chaîne, puis le planning, à ses fournisseurs de matériel roulant, amenant ainsi une modernisation de leurs méthodes de travail. L'adoption et la diffusion des méthodes d'organisation a impliqué une très forte centralisation des structures administratives, dont une illustration est donnée par le service d'entretien des wagons, où tous les ateliers sont dirigés par le service central des wagons de la direction du Matériel. Au début de la Seconde Guerre, les limites de cette centralisation vont être perçues par les fonctionnaires dirigeants qui avaient introduit les méthodes d'organisation tayloriennes. Il en résultera une décentralisation des responsabilités; son abandon au lendemain du conflit marque toutefois le retour à une centralisation taylorienne dont les effets se feront sentir pendant plusieurs décennies. [less ▲]

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See detailAnalytic quantification of solar lentigines lightening by a 2% hydroquinone-cyclodextrin formulation.
Petit, Ludivine; Pierard, Gérald ULiege

in Journal of the European Academy of Dermatology & Venereology (2003), 17(5), 546-9

BACKGROUND: The innate melanin pigmentation of skin is modulated during lifetime by a series of factors, including ageing and chronic ultraviolet light exposure. Actinic lentigines may be of particular ... [more ▼]

BACKGROUND: The innate melanin pigmentation of skin is modulated during lifetime by a series of factors, including ageing and chronic ultraviolet light exposure. Actinic lentigines may be of particular concern from a cosmetic point of view. Conventional hypopigmenting agents are usually deceptive. Using cyclodextrins to form inclusion compounds with these agents might represent a more active drug delivery system. OBJECTIVE: To assess sensitive and objective methods predicting the effects of a 2% hydroquinone-cyclodextrin formulation on solar lentigines. STUDY DESIGN: Thirty Asian adults applied a 2% hydroquinone-cyclodextrin formulation once daily on solar lentigines of a forearm for 2 months. The other untreated forearm served as a control. Monthly assessments were performed using skin colorimetry and fluorescence video recording combined with image analysis. Corneomelametry following photodensitometry of cyanoacrylate skin surface strippings was performed after melanin staining of the samples. RESULTS: The control untreated solar lentigines showed no significant variations in the biometrological parameters. By contrast, the test formulation induced lightening of the solar lentigines. Corneomelametry disclosed improvement after 1 months' treatment, whereas the other assessments only reached significance after 2 months. CONCLUSIONS: A 2% hydroquinone-cyclodextrin formulation proved to be effective in lightening actinic lentigines. Corneomelametry predicted the effects discernible at a later stage by in vivo colour assessments of the melanin content. [less ▲]

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See detailHDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.
Dequiedt, Franck ULiege; Kasler, Herbert; Fischle, Wolfgang et al

in Immunity (2003), 18(5), 687-98

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and ... [more ▼]

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and negative selection, via the transcription factor MEF2D. HDAC7 is exported from the nucleus during T cell receptor activation, leading to Nur77 expression. A triple HDAC7 mutant (S155A, S318A, S448A) is not exported from the nucleus in response to TCR activation and suppresses TCR-mediated apoptosis. Conversely, a fusion of HDAC7 to the transcriptional activator VP16 activates Nur77 expression. Inhibition of HDAC7 expression by RNA interference causes increased apoptosis in response to TCR activation. These observations define HDAC7 as a regulator of Nur77 and apoptosis in developing thymocytes. [less ▲]

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See detailInorganic and organic carbon biogeochemistry in the Gautami Godavari estuary (Andhra Pradesh, India) during pre-monsoon : the local impact of extensive mangrove forests
Bouillon, Steven; Frankignoulle, Michel; Dehairs, Frank et al

in Global Biogeochemical Cycles (2003), 17(4),

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the ... [more ▼]

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the oligohaline and mesohaline section (salinity 0–15) of the estuary, internal production of total alkalinity (TAlk) and dissolved inorganic carbon (DIC) was recorded, and the d13CDIC profile suggests that carbonate dissolution may be an important process determining the DIC dynamics in this section of the Godavari. The partial pressure of CO2 (pCO2) was fairly low along the entire salinity gradient, (293–500 ppm), but much higher and more variable (1375–6437 ppm) in the network of tidal mangrove creeks in the delta. Here, variations in the concentration and d13C of the DIC pool were shown to result largely from the mineralization of organic matter. The present study clearly identifies the mangrove creeks as an active site of mineralization and CO2 efflux to the atmosphere, but shows that these changes in the aquatic biogeochemistry are a localized feature, rapidly fading in the adjacent Kakinada Bay. Our data indicate that mineralization of dissolved organic carbon (DOC) of mangrove origin, and its subsequent efflux as CO2 to the atmosphere may represent an important fate for mangrove carbon. Although further quantification of this process in a variety of systems is required, we suggest that some of the current ideas on the role of mangroves in the carbon budget of the coastal zone may need to be reconsidered. [less ▲]

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See detailEpisode de dyspnée consécutive à une intoxication par l’ergot dans une exploitation laitière
Brihoum, Mounir ULiege; Desmecht, Daniel ULiege; Bony, S. et al

in Annales de Médecine Vétérinaire (2003), 147(5), 353-358

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These ... [more ▼]

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These troubles can be compared to many observations done in humans after long lasting treatments with ergot derivatives [less ▲]

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See detailSalmonella contamination of pigs and pork in an integrated pig production system
Korsak Koulagenko, Nicolas ULiege; Jacob, Benoit; Groven, Bénédicte et al

in Journal of Food Protection (2003), 66(7), 1126-1133

This paper describes the monitoring of Salmonella in a closed pig production system in Belgium over a 2-year period. A sampling scheme including animal feeds and carcasses was designed to cover the entire ... [more ▼]

This paper describes the monitoring of Salmonella in a closed pig production system in Belgium over a 2-year period. A sampling scheme including animal feeds and carcasses was designed to cover the entire chain of production from farrow to finishing pigs. Salmonella was detected by a method based on the use of semisolid Rappaport-Vassiliadis as a selective medium. The serotypes of the isolated strains were determined, and the antibiotic resistance of these strains to six antibiotics was also investigated. Feeds were found to be more contaminated than expected (10.2%, 34 of 332 samples). The percentage of positive fecal samples for pregnant sows (8.1%, 11 of 135 samples) was significantly higher than that for young and lactating sows (2.9%, 11 of 378 samples) (P<0.05). The percentage of positive samples for colon contents collected at the slaughterhouse (47.3%, 88 of 186 samples) was significantly higher than that for feces collected during the fattening stage (5.6%, 18 of 320 samples) (P<0.001). For carcass swab samples, the observed prevalence was 11.2% (17 of 152 samples). On farms, Salmonella recovery levels were higher for overshoe samples than for fecal samples, except for pregnant sows. Salmonella Typhimurium was the most frequently isolated serotype (32.2%, 55 of 171 samples), while Salmonella Brandenburg was predominant in the colon contents collected at the abattoir (21.4%, 18 of 84 samples). Feeds harbored a wide diversity of serotypes of minor epidemiological significance. Of 55 isolated strains of Salmonella Typhimurium, 11 (20%) were resistant to tetracycline, ampicillin, choramphenicol, streptomycin, trimethoprim, and nalidixic acid (R Type TeAmCSNa), while 12 (21.8%) were resistant to all of these antibiotics except nalidixic acid (R Type TeAmCS). The majority of Salmonella Typhimurium strains that exhibited resistance to more than four antimicrobial agents were characterized as Salmonella Typhimurium DT104 or as being closely related to Salmonella Typhimurium DT104 (7 of 12 isolates). In conclusion, our system of surveillance is effective in identifying most points of contamination in the production chain and will be useful in ongoing efforts to develop a Salmonella-free production system. [less ▲]

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See detailThéorie économique et marchandisation des services non marchands
Mertens de Wilmars, Sybille ULiege; Lefebvre, Mathieu ULiege

in Non Marchand : Management, Droit et Finance (2003), (11), 11-27

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See detailObservations sous Mons, 25 mars 2002
Leleu, Yves-Henri ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailImage analysis characterization of multi-walled carbon nanotubes
Gommes, Cédric ULiege; Blacher, Silvia ULiege; Masenelli-Varlot, Karine et al

in Carbon (2003), 41(13), 2561-2572

An original image analysis method is presented to characterize multi-walled carbon nanotubes from transmission electron microscopy images. The analysis is performed in three steps: (i) image preprocessing ... [more ▼]

An original image analysis method is presented to characterize multi-walled carbon nanotubes from transmission electron microscopy images. The analysis is performed in three steps: (i) image preprocessing in order to isolate the nanotubes from the background, (ii) image segmentation, aiming at keeping only the measurable sections of nanotubes, and finally (iii) tube characteristics measurement. The measurement is based on a Lambert-like electron absorption law and is performed on the original gray level image itself. Two geometrical and one physical characteristics are determined for each tube, namely, its outer and inner radius and a linear electron absorption coefficient. The method is illustrated by comparing a pristine and an annealed carbon nanotube samples. The compaction of the tube walls during annealing is shown to result from a lowering of the external radius while the inner radius is left unchanged. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailClonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases.
Herens, Christian ULiege; Baron, Frédéric ULiege; Croisiau, Christiane et al

in Cancer Genetics & Cytogenetics (2003), 147(1), 78-80

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal ... [more ▼]

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal chromosomal aberrations in Philadelphia-negative (Ph-) cells during treatment has been reported. We describe two CML patients in chronic phase who presented with complete cytogenetic responses during imatinib mesylate therapy but developed new clonal chromosomal rearrangements in Ph- cells. The first patient presented with a duplication of chromosome 1, dup(1)(q21q42), and the second showed two new clonal aberrations consisting of inv(1)(q12q32) and del(7)(q22) in the same clone. [less ▲]

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See detailEarly detection of relapse by whole-body positron emission tomography in the follow-up of patients with Hodgkin's disease.
Jerusalem, Guy ULiege; Beguin, Yves ULiege; Fassotte, Marie-France ULiege et al

in Annals of Oncology (2003), 14(1), 123-30

BACKGROUND: Relapse after treatment of Hodgkin's disease (HD) is usually identified as a result of the investigation of symptoms. We undertook this study to examine the value of whole-body positron ... [more ▼]

BACKGROUND: Relapse after treatment of Hodgkin's disease (HD) is usually identified as a result of the investigation of symptoms. We undertook this study to examine the value of whole-body positron emission tomography (PET) for the detection of preclinical relapse. PATIENTS AND METHODS: Thirty-six patients underwent 2-[fluorine-18]fluoro-2-deoxy-D-glucose ((18)F-FDG) PET at the end of treatment and than every 4-6 months for 2-3 years after the end of polychemotherapy and/or radiotherapy. In those cases of abnormal (18)F-FDG accumulation a confirmatory study was performed 4-6 weeks later. RESULTS: One patient had residual tumor and four patients relapsed during a follow-up of 5-24 months. All five events were correctly identified early by (18)F-FDG PET. Residual tumor or relapse was never first diagnosed based on clinical examination, laboratory findings or computed tomography (CT) studies. Two patients presented B symptoms and the three others were asymptomatic at the time of residual disease or relapse. Confirmation of residual disease or relapse was obtained by biopsy in four patients 1, 1, 5 and 9 months after PET and by unequivocal clinical symptoms and CT studies in one patient 3 months after PET. False-positive (18)F-FDG PET studies incorrectly suggested possible relapse in six other patients, but the confirmatory PET was always negative. Our study also provides important information about physiological (18)F-FDG uptake in the thymus. CONCLUSIONS: Our data suggest the potential of (18)F-FDG PET to detect preclinical relapse in patients with HD. This could help identify patients requiring salvage chemotherapy at the time of minimal disease rather than at the time of clinically overt relapse. Further studies are warranted to determine the impact of PET on treatment management and outcome. In fact, the aim of follow-up procedures is not only to detect preclinical relapse but mainly to obtain better results by starting salvage treatment earlier. A cost-benefit analysis will also be necessary before (18)F-FDG PET can be used routinely in the follow-up of patients with HD. [less ▲]

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See detailThe Portugal coastal counter current off NW Spain: new insights on its biogeochemical variability
Alvarez-Salgado, Xosé Antón; Figueiras, F. G.; Perez, F. F. et al

in Progress in Oceanography (2003), 56(2), 281-321

Time series of wind-stress data, AVHRR and SeaWiFS satellite images, and in situ data from seven cruises are used to assemble a coherent picture of the hydrographic variability of the seas off the ... [more ▼]

Time series of wind-stress data, AVHRR and SeaWiFS satellite images, and in situ data from seven cruises are used to assemble a coherent picture of the hydrographic variability of the seas off the Northwest Iberian Peninsula from the onset (September-October) to the cessation (February-May) of the Portugal coastal counter current (PCCC). During this period the chemistry and the biology of the shelf, slope and ocean waters between 40degrees and 43degreesN have previously been undersampled. Novel information extracted from these observations relate to: 1. The most frequent modes of variability of the alongshore coastal winds, covering event, seasonal and long-term scales; 2. The conspicuous cycling between stratification and homogenisation observed in PCCC waters, which has key implications for the chemistry and biology of these waters; 3. The seasonal evolution of nitrite profiles in PCCC waters in relation to the stratification cycle; 4. The Redfield stoichiometry of the remineralisation of organic matter in Eastern North Atlantic Central Water (ENACW)-the water mass being transported by the PCCC; 5. The separation of coastal (mesotrophic) from PCCC (oligotrophic) planktonic populations by a downwelling front along the shelf, which oscillates to and fro across the shelf as a function of coastal wind intensity and continental runoff; and 6. The photosynthetic responses of the PCCC and coastal plankton populations to the changing stratification and light conditions from the onset to the cessation of the PCCC. [less ▲]

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See detailAnalyse de la variabilité spatio-temporelle de la morphologie du chenal de la Warche en amont du barrage de Butgenbach (Belgique).
Assani, A. A.; Petit, François ULiege; Buffin-Belanger, T. et al

in Zeitschrift für Geomorphologie (2003)

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See detailCatabolism of hydroxyacids and biotechnological production of lactones by Yarrowia lipolytica
Waché, Y.; Aguedo, Mario ULiege; Nicaud, J.-M. et al

in Applied Microbiology and Biotechnology (2003), 61(5-6), 393-404

The γ- and δ-lactones of less than 12 carbons constitute a group of compounds of great interest to the flavour industry. It is possible to produce some of these lactones through biotechnology. For ... [more ▼]

The γ- and δ-lactones of less than 12 carbons constitute a group of compounds of great interest to the flavour industry. It is possible to produce some of these lactones through biotechnology. For instance, γ-decalactone can be obtained by biotransformation of methyl ricinoleate. Among the organisms used for this bioproduction, Yarrowia lipolytica is a yeast of choice. It is well adapted to growth on hydrophobic substrates, thanks to its efficient and numerous lipases, cytochrome P450, acylCoA oxidases and its ability to produce biosurfactants. Furthermore, genetic tools have been developed for its study. This review deals with the production of lactones by Y. lipolytica with special emphasis on the biotransformarion of methyl ricinoleate to γ-decalactone. When appropriate, information from the lipid metabolism of other yeast species is presented. [less ▲]

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See detailComment j'explore ... un trouble de la magnésémie
Boman, Xavier ULiege; Guillaume, Thierry; Krzesinski, Jean-Marie ULiege

in Revue Médicale de Liège (2003), 58(2), 104-108

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical ... [more ▼]

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical presentations and etiologies of hypo- and hypermagnesemia and their exploration. Hypomagnesemia frequently occurs but is clinically rarely recognized without biological serum ionic determinations because causing atypical signs miming those of other ion deficiencies. Hypermagnesemia is uncommon but often occurs in the presence of renal insufficiency especially with excess of Mg administration. [less ▲]

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See detailQuels rôles et quelle formation pour les tuteurs intervenant dans des dispositifs de formation à distance ?
Denis, Brigitte ULiege

in Distances et Savoirs (2003), 1(1), 19-46

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif ... [more ▼]

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. [less ▲]

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See detailA dip into the world of veterinary nuclear medicine: equine lung scintigraphy
Votion, Dominique ULiege; Lekeux, Pierre ULiege

in Clinical Techniques in Equine Practice (2003), 2(3), 222-230

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology ... [more ▼]

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology, for the knowledge of animal peculiarities, for the study and diagnosis of equine respiratory disorders as well as for the development of their treatment. This article surveys some methodological constraints due to the scanning of a noncooperative large-sized animal, reviews the contribution of equine nuclear imaging in lung physiology and pathology, and discusses future clinical and fundamental applications of lung scintigraphy. [less ▲]

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See detailAn intervention study to enhance postoperative pain management.
Bardiau, Françoise ULiege; Taviaux, Nicole F; Albert, Adelin ULiege et al

in Anesthesia and Analgesia (2003), 96(1), 179-85

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery ... [more ▼]

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery departments were involved. In this study we sought to evaluate the results of a continuous quality improvement program by defining quality indicators and using quality tools. A quality program in accordance with current standards of acute pain treatment (multimodal) was worked out to enhance pain relief for all surgical inpatients. A survey of nurses' knowledge with regard to postoperative pain was conducted, and a visual analog scale (VAS) was introduced to assess pain intensity. Both nurses and physicians became familiar with evidence-based guidelines concerning postoperative pain. The entire process was monitored in three consecutive surveys and enrolled 2383 surgical inpatients. Pain indicators based on VAS and analgesic consumption were recorded during the first 72 postoperative hours. After a baseline survey about current practices of pain treatment, a nurse-based, anesthesiologist-supervised APS was implemented. The improvement in pain relief, expressed as VAS scores, was assessed in two further surveys. A quality manual was written and implemented. A major improvement in pain scores was observed after the APS inception (P < 0.001). IMPLICATIONS: The implementation of an acute pain service, including pain assessment by a visual analog scale, standard multimodal pain treatment, and continuous quality evaluation, improved postoperative pain relief. Establishing teams of surgeons, anesthesiologists, and nurses is the prerequisite for this improvement. [less ▲]

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See detailRecension critique : La fin de l'Ecole
Guillaume, Jean-François ULiege

in Schweizerische Zeitschrift für Soziologie = Revue Suisse de Sociologie (2003), 29(1), 195-198

Les analyses, polémiques, sur l'avenir de l'institution scolaire (l'Ecole) ne manquent pas en cette période de glissements des modèles pédagogiques et d'affirmation de nouvelles orientations politiques ... [more ▼]

Les analyses, polémiques, sur l'avenir de l'institution scolaire (l'Ecole) ne manquent pas en cette période de glissements des modèles pédagogiques et d'affirmation de nouvelles orientations politiques tenant, entre autres, à l'imposition d'un modèle centré sur le "long life learning". Mais (ré)affirmer la nécessité d'un ordre républicain permettra-t-il d'affronter les nouveaux enjeux de l'éducation des générations actuelles ? [less ▲]

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See detailA recombinant 31.5 kDa keratinase and a crude exo-antigen from Microsporum canis fail to protect against a homologous experimental infection in guinea pigs.
Descamps, Frederic F; Brouta, Frederic; Vermout, Sandy M et al

in Veterinary Dermatology (2003), 14(6), 305-312

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three ... [more ▼]

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three times at two-week intervals with either the keratinase, the exo-antigen or the adjuvant alone. Cutaneous challenge was performed blindly. Both humoral and cellular-specific immune responses to M. canis antigens were evaluated every 14 days, while a blind evaluation of clinical lesion development and fungal persistency in skin were monitored weekly. Vaccination induced very high and significant (P < 0.01) antibody responses towards both antigens. High cell-mediated immune responses to both immunogens were also induced by vaccination. After challenge, however, scores reflecting the severity of dermatophytic lesions did not differ significantly between vaccinated and control groups at any time after challenge. These results suggest that, in the guinea pig, the induction of specific immune responses against the M. canis-secreted antigens used in this study are not protective against challenge exposure. [less ▲]

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See detailDie Umsetzung der Kaufrechtsrichtlinie (1999/44/EG) in Belgien
Gerkens, Jean-François ULiege; Pirson, Valérie

in Martin Schermaier (Hrsg.) Verbraucherkauf in Europa (2003)

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See detailPatterns of molecular and morphological variation in Leucobryum albidum, L. Glaucum, and L-juniperoideum (Bryopsida)
Vanderpoorten, Alain ULiege; Boles, S.; Shaw, A. J.

in Systematic Botany (2003), 28(4, OCT-DEC), 651-656

Restriction digest patterns from 18S-26S nuclear ribosomal DNA internal transcribed spacers (ITS) were employed to investigate delineation between the morphologically similar moss species Leucobryum ... [more ▼]

Restriction digest patterns from 18S-26S nuclear ribosomal DNA internal transcribed spacers (ITS) were employed to investigate delineation between the morphologically similar moss species Leucobryum glaucum, L. juniperoideum, and L. albidum. Discriminant analysis allowed assignment of specimens to haplotypes based on their morphological features and supported the recognition of L. glaucum and L. albidum. In contrast, L. albidum and L. juniperoideum both corresponded to the same haplotype. Many populations could be readily assigned to either L. glaucum or L. albidum by their morphological features. However, morphological variation between these two species was continuous and one of the ITS haplotypes could not be unambiguously characterized by its morphology. Genetically and morphologically identifiable specimens of L. albidum were sampled in Europe and North America, in contrast to the traditional interpretation of L. albidum as a North American endemic. Although L. albidum seems to have a more southern-Atlantic distribution pattern than L. glaucum, the two species occupy broadly overlapping geographic ranges and were sometimes found intermixed. [less ▲]

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See detailLa guerre et la médecine d'une culture de paix. 4- Synopsis des armes nucléaires.
Pierard, Gérald ULiege

in FALCO (2003), Fevrier

The nuclear weapons have a terrifying power of devastation. A civilan nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical consequences ... [more ▼]

The nuclear weapons have a terrifying power of devastation. A civilan nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical consequences. The Gulf war and Balkan war syndromes might be in part caused by uranium used in conventional amunitions. Th erisk of nuclear terrorism is an emerging eventuality. [less ▲]

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See detailAnalysis of bivariate tail dependence using extreme values copulas: An application to the SOA medical large claims database
Cebrian, Ana; Denuit, Michel; Lambert, Philippe ULiege

in Belgian Actuarial Bulletin (2003)

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See detailMultiscale texture characterization of wastewater sludges dried in a convective rig
Léonard, Angélique ULiege; Blacher, Silvia ULiege; Pirard, René ULiege et al

in Drying Technology (2003), 21(8), 1507-1526

Secondary sludges from two different wastewater treatment plants are conditioned and dewatered in the same way before drying in a lab-scale convective rig at the same operating conditions. Several ... [more ▼]

Secondary sludges from two different wastewater treatment plants are conditioned and dewatered in the same way before drying in a lab-scale convective rig at the same operating conditions. Several techniques are used to characterize the texture of the dried materials over a wide range of scales from nm up to mm. Texture and porosity of the dried products are studied by SEM imaging, nitrogen absorption isotherms (0.5 < d(p) < 50 nm), mercury porosimetry (7.5 nm < d(p) < 150 mum) and X-ray microtomography (spatial resolution= 41 mum). The image analysis of cross-sections reconstructed by microtomography also allows following shrinkage and textural evolution during drying. [less ▲]

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See detailRecent advances in the study of lanthanide atoms and ions
Biémont, Emile ULiege; Quinet, Pascal ULiege

in Physica Scripta (2003), T105

We present an overview of the recent developments concerning the spectroscopic properties of lanthanide atoms and ions (Z = 57-71). This review is focussed on the advances made during the past twenty ... [more ▼]

We present an overview of the recent developments concerning the spectroscopic properties of lanthanide atoms and ions (Z = 57-71). This review is focussed on the advances made during the past twenty years regarding the analysis of the spectra, the transition probabilities, the radiative lifetimes and also the hyperfine structures and isotope shifts. Theoretical aspects as well as experimental measurements are both covered in this paper including bibliographical references up to the end of 2001. Some astrophysical implications of the new atomic data concerning the chemical composition of the sun are briefly reviewed. Emphasis is also put on the new database D.R.E.A.M. developed on a web site of Mons University in Belgium. [less ▲]

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See detailThe thymic insulin-like growth factor axis: Involvement in physiology and disease
Geenen, Vincent ULiege

in Hormone & Metabolic Research (2003), 35(11-12, Nov-Dec), 656-663

A repertoire of neuroendocrine-related genes is transcribed in the non-lymphoid compartment of the thymus, transposing the dual physiological role of this organ at the molecular level in T-cell ... [more ▼]

A repertoire of neuroendocrine-related genes is transcribed in the non-lymphoid compartment of the thymus, transposing the dual physiological role of this organ at the molecular level in T-cell development towards the establishment of central T-cell self-tolerance. The "neuroendocrine self" has been defined as a series of antigen sequences processed from precursors predominantly expressed in the thymus and first encountered by differentiating T-lymphocytes in their early life. All the members of the insulin gene family are expressed in the thymus according to a precise hierarchy and cellular topography, whereby IGF-II (epithelium of the subcapsular cortex and medulla) exceeds IGF-I (macrophages), which in turn far exceeds INS (rare subsets of medullary epithelial cells). This hierarchy in the degree of their respective thymic expression explains why IGF-II is more tolerated than IGF-I, and much more so than insulin. Evidence has been found for significant regulatory/tolerogenic properties in the IGF-II B:11-25 sequence after analysis of the cytokine secretion profile in peripheral blood mononuclear cells isolated from ten DQ8+ type 1 diabetic adolescents. In the thymus, IGF ligands and receptors also intervene in the control of T-cell proliferation and differentiation. Here, we also discuss how a disturbance in the intrathymic IGF-mediated signaling could contribute to the pathogenesis of T-cell leukemia. [less ▲]

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See detailExamen de jurisprudence (1995-2001). Contrat de travail
Kefer, Fabienne ULiege; Clesse, Jacques ULiege

in Revue Critique de Jurisprudence Belge (2003)

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See detailVitamine E: état des connaissances chez les carnivores domestiques. II Métabolisme, besoins et apports
Cuvelier, Christine ULiege; Dotreppe, Olivier ULiege; Diez, Marianne ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 367-382

This paper aims to present the metabolism of vitamin E and the allowances and requirements in men and domestic carnivores. The mechanisms of absorption, distribution, storage and excretion of vitamin E ... [more ▼]

This paper aims to present the metabolism of vitamin E and the allowances and requirements in men and domestic carnivores. The mechanisms of absorption, distribution, storage and excretion of vitamin E are explained. The metabolism particularities of this vitamin due to the existence of the a-Tocopherol Transfer Protein are developed. The concentrations in lipoproteins and plasma are presented along with their variation factors. Vitamin E units, estimation of requirements and dietary allowances and tolerable upper intake level in men and domestic carnivores are also reviewed. Finally, the use of vitamin E in the petfood industry is discussed. [less ▲]

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See detailFattening of Belgian Blue double-muscled culled females: animal performance, carcass characteristics and meat quality
Cabaraux, Jean-François ULiege; Hornick, Jean-Luc ULiege; Dufrasne, Isabelle ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 423-431

In order to measure Animal performance and, carcass and meat characteristics of Belgian Blue double-muscled culled females, a fattening trial was carried out on a total of 78 animals. Fifteen females were ... [more ▼]

In order to measure Animal performance and, carcass and meat characteristics of Belgian Blue double-muscled culled females, a fattening trial was carried out on a total of 78 animals. Fifteen females were slaughtered at the beginning of the trial and 63 were fattened on a maize silage based diet. The initial average live weight was 571.2kg. The total fattening gain was 91.1 kg for a period of 91.4 days. At slaughter, the warm carcass weight was 405.9kg and the killing-out proportion 63.3%. The carcasses were characterised by a high proportion of muscles (67.6%) and rather low proportions of adipose tissue (18.2%) and bones (14.2%). The muscle and adipose tissue accretions were 36.0 and 28.2 kg. Meat was lean as indicated by high protein content (88.5%) and low fat content (6.6%) in dry matter. A high proportion of polyunsaturated fatty acids was also found (6.8 mol %). [less ▲]

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See detailTuning of ruthenium N-heterocyclic carbene catalysts for ATRP
Delaude, Lionel ULiege; Delfosse, Sébastien ULiege; Richel, Aurore ULiege et al

in Chemical Communications (2003), (13), 1526-1527

Depending on the substituents, R-1 and R-2, ruthenium(II) - p-cymene complexes bearing N-heterocyclic carbene ligands are either efficient catalysts for the well-controlled atom transfer radical ... [more ▼]

Depending on the substituents, R-1 and R-2, ruthenium(II) - p-cymene complexes bearing N-heterocyclic carbene ligands are either efficient catalysts for the well-controlled atom transfer radical polymerisation of methyl methacrylate and styrene, or promote a redox-initiated free-radical process. [less ▲]

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See detailEffect of somatic growth, strain and sex on double-chamber plethysmographic respiratory function values in healthy mice
Flandre, Thierry; Leroy, Pascal ULiege; Desmecht, Daniel ULiege

in Journal of Applied Physiology (2003), 94

Double-chamber plethysmography has been recognized since 1979 as a reference technique to measure pulmonary function values in guinea pigs, but it has not gained attention for use in mice. Theoretically ... [more ▼]

Double-chamber plethysmography has been recognized since 1979 as a reference technique to measure pulmonary function values in guinea pigs, but it has not gained attention for use in mice. Theoretically, however, this technique combines the advantages of single-chamber plethysmography with a quantitative assessment of flow and/or volume and a calculated resistance, the interpretation of which in terms of bronchoconstriction is not disputed. Here we show that, when appropriately preconditioned, mice are able to gradually grow accustomed to the apparatus and display extremely stable nasal and thoracoabdominal flow tracings. Overall, strain, sex, and somatic growth had a significant effect on pulmonary function values. The changes in specific airway resistance (sRaw) and enhanced pause (Penh) values were never in the same direction, indicating that they measure different things. The respiratory frequency was far higher in C57BL/6 compared with BALB/c mice. Peak flows, minute volume, specific tidal and minute volumes, and sRaw were also higher, but Penh was smaller. Males breathed at a higher frequency than females, leading to a higher minute volume. Nevertheless, the specific volumes were considerably higher among females. Penh was lower in males, whereas sRaw was identical in both sexes. Changes associated with somatic growth were rapid and important between 5 and 9 wk, then slowed down between 9 and 12-13 wk and became almost imperceptible after. [less ▲]

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See detailModeling lactation curves and estimation of genetic parameters for first lactation test-day records of French Holstein cows.
Druet, Tom ULiege; Jaffrezic, F.; Boichard, D. et al

in Journal of Dairy Science (2003), 86(7), 2480-90

Several functions were used to model the fixed part of the lactation curve and genetic parameters of milk test-day records to estimate using French Holstein data. Parametric curves (Legendre polynomials ... [more ▼]

Several functions were used to model the fixed part of the lactation curve and genetic parameters of milk test-day records to estimate using French Holstein data. Parametric curves (Legendre polynomials, Ali-Schaeffer curve, Wilmink curve), fixed classes curves (5-d classes), and regression splines were tested. The latter were appealing because they adjusted the data well, were relatively insensitive to outliers, were flexible, and resulted in smooth curves without requiring the estimation of a large number of parameters. Genetic parameters were estimated with an Average Information REML algorithm where the average information matrix and the first derivatives of the likelihood functions were pooled over 10 samples. This approach made it possible to handle larger data sets. The residual variance was modeled as a quadratic function of days in milk. Quartic Legendre polynomials were used to estimate (co)variances of random effects. The estimates were within the range of most other studies. The greatest genetic variance was in the middle of the lactation while residual and permanent environmental variances mostly decreased during the lactation. The resulting heritability ranged from 0.15 to 0.40. The genetic correlation between the extreme parts of the lactation was 0.35 but genetic correlations were higher than 0.90 for a large part of the lactation. The use of the pooling approach resulted in smaller standard errors for the genetic parameters when compared to those obtained with a single sample. [less ▲]

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See detailGeneralized Pareto fit to the Society of Actuaries large claims database
Cebrian, Ana; Denuit, Michel; Lambert, Philippe ULiege

in North American Actuarial Journal (2003), 7

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See detailIntegrated detection and correction of outliers in a random regression test-day model
Mayeres, Patrick; Gillon, Alain ULiege; Gengler, Nicolas ULiege

in INTERBULL Bulletin (2003), 31

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See detailOptimisation Of Expression And Immobilized Metal Ion Affinity Chromatographic Purification Of Recombinant (His)(6)-Tagged Cytochrome P450 Hydroperoxide Lyase In Escherichia Coli
Delcarte, J.; Fauconnier, Marie-Laure ULiege; Jacques, Philippe ULiege et al

in Journal of Chromatography B-Analytical Technologies In the Biomedicaland Life Sciences (2003), 786(1-2),

Fatty acid hydroperoxide lyase (HPL) is a cytochrome P450 acting on fatty acid’s hydroperoxides in many plants. The optimisation of the expression of recombinant (His) -tagged HPL in Escherichia coli is ... [more ▼]

Fatty acid hydroperoxide lyase (HPL) is a cytochrome P450 acting on fatty acid’s hydroperoxides in many plants. The optimisation of the expression of recombinant (His) -tagged HPL in Escherichia coli is described: the highest HPL 6 production yield were obtained with TB medium supplemented with 2.5 mM d-aminolevulinic acid and 0.5 mM IPTG. For the first time, the time course expression of a plant P450 in a bench-scale fermentor is detailed and the amount of recombinant HPL production is 16.3 mg/ l. The UV–Visible spectrum of the recombinant (His) -tagged HPL have been recorded after a Ni -based affinity chromatography (IMAC). [less ▲]

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See detailLeclercq Suzanne.
Streel, Maurice ULiege; Fairon-Demaret, M

in Académie Royale des sciences lettres et beaux arts de Belgique/ Nouvelle biographie nationale (2003), 7

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See detailLes échecs électifs en mathématique : un regard inspiré de la didactique.
Schneider, Marguerite ULiege

in Mathématique et Pédagogie (2003), 140

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See detailRecognising the usual orientation of one's own face : the role of asymmetrically located details
Brédart, Serge ULiege

in Perception (2003), 32(7), 805-811

Our ability to recognise the usual horizontal orientation Of Our own face (mirror orientation) as compared with another very familiar face (normal orientation) was examined in experiment 1. Participants ... [more ▼]

Our ability to recognise the usual horizontal orientation Of Our own face (mirror orientation) as compared with another very familiar face (normal orientation) was examined in experiment 1. Participants did not use the same kind of information in determining the orientation of their own face as in determining the orientation of the other familiar face. The proportion of participants who reported having based their judgment on the location of an asymmetric feature (eg a mole) was higher when determining the orientation of their own face than when determining that of the other familiar face. In experiment 2, participants were presented with pairs of manipulated images of their own face and of another familiar face showing conflicting asymmetric features and configural information. Each pair consisted of one picture showing asymmetric features of a given face in a mirror-reversed position, while the facial configuration was left unchanged; and one picture in which the location of the asymmetric features was left unchanged, while the facial configuration was mirror-reversed. As expected from the hypothesis that asymmetric local features are more frequently used for the judgment of one's own face, participants chose the picture showing mirror-reversed asymmetric features when determining the usual orientation of their own face significantly more often than they chose the picture showing normally oriented asymmetric features when determining the orientation of the other face. These results are explained in terms of competing forward and mirror-reversed representations of one's own face. [less ▲]

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See detailRole of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase.
Vanhove, Marc; Zakhem, M.; Devreese, B. et al

in Cellular and molecular life sciences : CMLS (2003), 60(11), 2501-9

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results ... [more ▼]

The CphA metallo-beta-lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results in a drastic decrease in the hydrolytic activity. In this study, we analyzed the role of Asn116 and Cys221, two residues of the active site. These residues were replaced by site-directed mutagenesis and the different mutants were characterized. The C221S and C221A mutants were seriously impaired in their ability to bind the first, catalytic zinc ion and were nearly completely inactive, indicating a major role for Cys221 in the binding of the catalytic metal ion. By contrast, the binding of the second zinc ion was only slightly affected, at least for the C221S mutant. Mutation of Asn116 did not lead to a drastic decrease in the hydrolytic activity, indicating that this residue does not play a key role in the catalytic mechanism. However, the substitution of Asn116 by a Cys or His residue resulted in an approximately fivefold increase in the affinity for the second, inhibitory zinc ion. Together, these data suggested that the first zinc ion is located in the binding site involving the Cys221 and that the second zinc ion binds in the binding site involving Asn116 and, presumably, His118 and His196. [less ▲]

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See detailEffect of nutrient enrichments on the bacterial assemblage of Antarctic soils contaminated by diesel or crude oil
Delille, Daniel; Pelletier, Emilien; Delille, Bruno ULiege et al

in Polar Record (2003), 39(4), 309-318

There is an urgent need to develop new technologies to address the problem of soil remediation in high-latitude regions. A field study was initiated in January 1997 in two contaminated soils in Terre ... [more ▼]

There is an urgent need to develop new technologies to address the problem of soil remediation in high-latitude regions. A field study was initiated in January 1997 in two contaminated soils in Terre Adélie (Antarctica) with the objective of determining the long-term effectiveness of two bioremediation agents on total and hydrocarbon-degrading microbial assemblages under severe Antarctic conditions. This study was conducted in two steps, from January to July 1997 and from February to November 1999 in the Géologie Archipelago (Terre Adélie, 66°40′S, 140°01′E). Changes in bacterial communities were monitored in situ after crude oil or diesel addition in a series of 600 cm2 soil sectors (20×30 cm). Four contaminated sectors were used for each experiment: diesel oil (10 ml), diesel oil (10 ml) + fertilizer (1 ml), Arabian light crude oil (10 ml), and crude oil (10 ml) + fertilizer (1 ml). Two different bioremediation agents were used: a slow release fertilizer Inipol EAP-22 (Elf Atochem) in 1997 and a fish compost in 1999. Plots were sampled on a regular basis during a three-year period. All samples were analysed for total, saprophytic psychrophilic, and hydrocarbon-utilising bacteria. A one order of magnitude increase of saprophytic and hydrocarbon-utilising micro-organisms occurred during the first month of the experiment in most of the contaminated enclosures, but no clear differences appeared between fertilized and unfertilized plots. Diesel-oil contamination induced a significant increase of all bacterial parameters in all contaminated soils. Crude-oil contamination had no clear effects on microbial assemblages. It was clear that the microbial response could be rapid and efficient in spite of the severe weather conditions. However, microbial growth was not clearly improved in the presence of bioremediation agents. [less ▲]

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See detailPropriétés des merrains affinés dans une solution d’enzymes naturels et destinés à la tonnellerie
Jourez, Benoît ULiege; Charron, Stéphane; Hebert, Jacques ULiege

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60

Properties of shooks ageing by a treatment in a solution of natural enzymes. A speeding up of the ageing of shooks is possible by a treatment with a solution of natural enzymes. However its repercussion ... [more ▼]

Properties of shooks ageing by a treatment in a solution of natural enzymes. A speeding up of the ageing of shooks is possible by a treatment with a solution of natural enzymes. However its repercussion on physical, mechanical characteristics of wood and on its absorption potential of an hydro-alcoholic solution must be tested. Normalized samples have been extracted from 150 shooks selected on a ring width criteria from three cooperages located on different supplying area in France. The three factors cooperage, ring width class and treatment are used for statistical analysis. The cooperage factor, reflection of the supply area of each of them, affect the young modulus and the modulus of rupture in static bending but not the other characteristics. The improvement of the wood properties is closely linked to the ring width increaseof the samples. The enzymatic treatment has no significant effect on physical and mechanical characteristics of oak wood, except on the hardness and, to a lesser extent, on the absorption potential. Considering the absence of negative effect on characteristics of shooks and the positive contribution of enzymatic treatment on their ageing, this treatment could bring a very interesting economical alternative permitting to avoid long lasting storage of the shooks before assembly. [less ▲]

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See detailProstatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation.
Cornet, Anne ULiege; Hanon, Emmanuel; Reiter, Eric R et al

in Prostate (The) (2003), 56(3), 220-30

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen ... [more ▼]

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen withdrawal. The regulation of PARM-1 by androgens is limited to this organ. We have studied the effects of PARM-1 overexpression in malignant prostate cells. METHODS: The PARM-1 cDNA was introduced into the rat cancer cell line MAT LyLu along with a doxycycline-dependent regulator. RESULTS: Maximal expression of PARM-1 (fivefold induction) was achieved by incubating the cells with 2 microM doxycycline for 48 hr. A study investigating the effect of PARM-1 overexpression on the transcription of 588 genes has shown that the TLP1 gene (encoding rat telomerase protein component 1) was the most up-regulated (fourfold). In addition, a dose-dependent increase in telomerase activity was observed in cells overexpressing PARM-1. In vivo, the androgen-deprived prostate showed an increased TLP1 level and increased telomerase activity. CONCLUSIONS: Increased telomerase activity is often associated with the immortalisation of cancer cell lines, particularly prostatic ones. This could mean that PARM-1 is involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells. [less ▲]

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See detailImpact Of The Horizontal Movements Of A Sprayer Boom On The Longitudinal Spray Distribution In Field Conditions
Ooms, David ULiege; Ruter, R.; Lebeau, Frédéric ULiege et al

in Crop Protection (2003), 22(6),

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See detailThiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals
Makarchikov, Alexander F; Lakaye, Bernard ULiege; Gulyai, I. E. et al

in Cellular and Molecular Life Sciences : CMLS (2003), 60(7), 1477-1488

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain ... [more ▼]

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain proteins. Here we show that ThTP exists not only in vertebrates but is present in bacteria, fungi, plants and invertebrates. Unexpectedly, we found that in Escherichia coli as well as in Arabidopsis thaliana, ThTP was synthesized only under particular circumstances such as hypoxia (E. coli) or withering (A. thaliana). In mammalian tissues, ThTP concentrations are regulated by a specific thiamine triphosphatase that we have recently characterized. This enzyme was found only in mammals. In other organisms, ThTP can be hydrolyzed by unspecific phosphohydrolases. The occurrence of ThTP from prokaryotes to mammals suggests that it may have a basic role in cell metabolism or cell signaling. A decreased content may contribute to the symptoms observed during thiamine deficiency. [less ▲]

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See detailHaplotype diversity of the myostatin gene among beef cattle breeds
Dunner, S.; Miranda, M. E.; Amigues, Y. et al

in Genetics, Selection, Evolution (2003), 35(1, JAN-FEB), 103-118

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were ... [more ▼]

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were identified which contribute to the high polymorphism (1 SNP every 100 bp) present in this small gene; twenty haplotypes were described and a genotyping method was set up using the Oligonucleotide Ligation Assay (OLA) method. Some haplotypes appeared to be exclusive to a particular breed; this was the case for 5 in the Charolaise (involving mutation Q204X) and 7 in the Maine-Anjou (involving mutation E226X). The relationships between the different haplotypes were studied, thus allowing to test the earlier hypothesis on the origin of muscular hypertrophy in Europe: muscular hypertrophy (namely m821 (del11)) was mainly spread in different waves from northern Europe milk purpose populations in most breeds; however, other mutations (mostly disruptive) arose in a single breed, were highly selected and have since scarcely evolved to other populations. [less ▲]

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See detailLa loi du 11 mai 2003 relative à la recherche sur les embryons in vitro
Leleu, Yves-Henri ULiege

in Revue Trimestrielle de Droit Familial (2003)

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See detailFaillite de l'imaginaire, la dermatite atopique ?
Dracoulis, H.; Gauthier, Jean-Marie ULiege

in Revue Française de Psychiatrie et de Psychologie Médicale (2003), 7(66), 51-56

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation.
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailCatecholamine and HPA axis dysfunction in depression : relationship with suicidal behavior
Pitchot, William ULiege; Reggers, Jean ULiege; Pinto, Emmanuel ULiege et al

in Neuropsychobiology (2003), 47(3), 152-157

A large body of evidence suggests a potential role for catecholaminergic function as a possible biological factor in the control of suicidal behavior. Recently, we have used a neuroendocrine strategy to ... [more ▼]

A large body of evidence suggests a potential role for catecholaminergic function as a possible biological factor in the control of suicidal behavior. Recently, we have used a neuroendocrine strategy to study dopaminergic and noradrenergic activities in depressed suicide attempters. However, some problems are associated with the use of growth hormone (GH) response to catecholaminergic challenge, because GH release could be decreased by a direct effect of corticosteroids at the pituitary level. Therefore, the purpose of the present study was to assess GH response to both apornorphine, a dopaminergic agonist, and clonidine, an alpha2-adrenergic agonist, according to the dexamethasone suppression test (DST) status in a sample of 20 major depressed inpatients with a history of suicide attempt compared with nonattempters. Our results tended to show that hypercortisolemia as assessed by post-DST cortisol values did not inhibit GH response to apornorphine or clonidine, suggesting that hypothalamo-pituitary-adrenal axis overactivity does not explain the impaired GH response to apornorphine in major depressed patients with a history of suicide attempt. [less ▲]

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See detailFamilial abdominal aortic aneurysms: collection of 233 multiplex families.
Kuivaniemi, Helena; Shibamura, Hidenori; Arthur, Claudette et al

in Journal of Vascular Surgery (2003), 37(2), 340-5

OBJECTIVE: This study investigated a large number of families in which at least two individuals were diagnosed with abdominal aortic aneurysms to identify the relationship of the affected relatives to the ... [more ▼]

OBJECTIVE: This study investigated a large number of families in which at least two individuals were diagnosed with abdominal aortic aneurysms to identify the relationship of the affected relatives to the proband. Subjects and Methods: Families for the study were recruited through various vascular surgery centers in the United States, Finland, Belgium, Canada, the Netherlands, Sweden, and the United Kingdom and through our patient recruitment website (www.genetics.wayne.edu/ags). RESULTS: We identified 233 families with at least two individuals diagnosed with abdominal aortic aneurysms. The families originated from nine different nationalities, but all were white. There were 653 aneurysm patients in these families, with an average of 2.8 cases per family. Most of the families were small, with only two affected individuals. There were, however, six families with six, three with seven, and one with eight affected individuals. Most of the probands (82%) and the affected relatives (77%) were male, and the most common relationship to the proband was brother. Most of the families (72%) appeared to show autosomal recessive inheritance pattern, whereas in 58 families (25%), abdominal aortic aneurysms were inherited in autosomal dominant manner, and in eight families, the familial aggregation could be explained by autosomal dominant inheritance with incomplete penetrance. In the 66 families where abdominal aortic aneurysms were inherited in a dominant manner, 141 transmissions of the disease from one generation to another were identified, and the male-to-male, male-to-female, female-to-male, and female-to-female transmissions occurred in 46%, 11%, 32%, and 11%, respectively. CONCLUSION: Our study supports previous studies about familial aggregation of abdominal aortic aneurysms and suggests that first-degree family members, male relatives, in particular, are at increased risk. No single inheritance mode could explain the occurrence of abdominal aortic aneurysms in the 233 families studied here, suggesting that abdominal aortic aneursyms are a multifactorial disorder with multiple genetic and environmental risk factors. [less ▲]

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See detailLe Rôle des antioxydants dans la prise en charge des maladies articulaires.
Mathy-Hartert, M.; Burton, S.; Deby-Dupont, G. et al

in Dieta (2003), 33

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See detailConsequences of imperfect insulation - Numerical Modelling
Franssen, Jean-Marc ULiege

in Journal of Fire Protection Engineering (2003), 18

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See detailComparison of change in bone resorption and bone mineral density with once-weekly alendronate and daily risedronate: a randomised, placebo-controlled study
Hosking, D.; Adami, S.; Felsenberg, D. et al

in Current Medical Research & Opinion (2003), 19(5), 383-394

Objective: To compare the effects of alendronate (ALN) 70 mg once weekly (OW) and risedronate (RIS) 5 mg daily between-meal dosing on biochemical markers of bone turnover and bone mineral density (BMD) in ... [more ▼]

Objective: To compare the effects of alendronate (ALN) 70 mg once weekly (OW) and risedronate (RIS) 5 mg daily between-meal dosing on biochemical markers of bone turnover and bone mineral density (BMD) in postmenopausal women with osteoporosis. Research design and methods: This was a 3-month, randomised, double-blind, placebo-controlled study with a double-blind extension to 12 months. The study enrolled 549 postmenopausal women (ALN 219, RIS 222 and placebo (PBO) 108) who were : 60 years of age at outpatient centres. Main outcome measures: The primary endpoint was reduction in urine N-telopeptides of type 1 collagen (NTx) corrected for creatinine level at 3 months. Secondary parameters included change in BMD at the spine and hip at 6 and 12 months, NTx at 1, 6 and 12 months, and serum bone-specific alkaline phosphatase (BSAP) at 1, 3, 6 and 12 months. Adverse experiences (AEs) were recorded throughout the study for an assessment of treatment safety profiles and tolerability. Results: Over 3 months, ALN produced a significantly greater mean reduction in urine NTx than did RIS (-52% vs -32%, p < 0.001), which was maintained at 12 months. ALN produced a significantly greater mean BMD increase than did RIS at 6 months, and it was maintained at 12 months at the lumbar spine (4.8% vs 2.8%, p < 0.001) and total hip (2.7% vs 0.9%, p < 0.001), as well as at the trochanter and femoral neck. Significant reductions in BSAP with ALN compared to RIS were maintained over the 12 months of treatment. Study size did not allow for meaningful assessment of differences in fracture rates. Tolerability was generally similar between ALN, RIS and PBO, and the incidence of upper GI AEs causing discontinuation and oesophageal AEs was similar in the ALN and RIS groups. Conclusion: In this study, ALN 70 mg OW produced a 50% greater reduction in bone resorption as measured by urine NTx and significantly greater increases in lumbar spine and hip BMD than did RIS 5 mg daily. The treatments had similar safety profiles and were generally well-tolerated. Additional studies are needed comparing OW ALN with OW RIS, which became available after the commencement of the present study. [less ▲]

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See detailRegulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Mottet, Denis ULiege; Dumont, Valery; Deccache, Yann et al

in Journal of Biological Chemistry (2003), 278(33), 31277-85

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms ... [more ▼]

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms involving stabilization of HIF-1alpha, phosphorylations, modifications of redox conditions, and interactions with coactivators. However, it appears that some of these steps can be cell type-specific. Among them, the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in the regulation of HIF-1 by hypoxia remains controversial. Here, we investigated the activation state of PI3K/Akt/glycogen synthase kinase 3beta (GSK3beta) in HepG2 cells. Increasing incubation times in hypoxia dramatically decreased both the phosphorylation of Akt and the inhibiting phosphorylation of GSK3beta. The PI3K/Akt pathway was necessary for HIF-1alpha stabilization early during hypoxia. Indeed, its inhibition was sufficient to decrease HIF-1alpha protein level after 5-h incubation in hypoxia. However, longer exposure (16 h) in hypoxia resulted in a decreased HIF-1alpha protein level compared with early exposure (5 h). At that time, Akt was no longer present or active, which resulted in a decrease in the inhibiting phosphorylation of GSK3beta on Ser-9 and hence in an increased GSK3beta activity. GSK3 inhibition reverted the effect of prolonged hypoxia on HIF-1alpha protein level; more stabilized HIF-1alpha was observed as well as increased HIF-1 transcriptional activity. Thus, a prolonged hypoxia activates GSK3beta, which results in decreased HIF-1alpha accumulation. In conclusion, hypoxia induced a biphasic effect on HIF-1alpha stabilization with accumulation in early hypoxia, which depends on an active PI3K/Akt pathway and an inactive GSK3beta, whereas prolonged hypoxia results in the inactivation of Akt and activation of GSK3beta, which then down-regulates the HIF-1 activity through down-regulation of HIF-1alpha accumulation. [less ▲]

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See detailLa Convention de Bruxelles
Boularbah, Hakim ULiege; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (2003)

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See detailSpecial issue on properties of concrete and behavior of concrete columns subjected to fire
Franssen, Jean-Marc ULiege

in Fire Technology (2003), 39(1), 97

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See detailRENO, a European Postmarket Surveillance Registry, confirms effectiveness of coronary brachytheraypy in routine clinical practice.
Coen, V; Serruys, P; Sauerwein, W et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 55(4), 1019-1026

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or ... [more ▼]

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or bypass grafts) treated with -radiation. Methods and Materials: Between April 1999 and September 2000, 1098 consecutive patients treated in 46 centers in Europe and the Middle East with the Novoste Beta-Cath System were included in Registry Novoste (RENO). Results: Six-month follow-up data were obtained for 1085 patients. Of 1174 target lesions, 94.1% were located in native vessels and 5.9% in a bypass graft; 17.7% were de novo lesions, 4.1% were restenotic, and 77.7% were in-stent restenotic lesions. Intravascular brachytherapy was technically successful in 95.9% of lesions. Multisegmental irradiation, using a manual pullback stepping maneuver to treat longer lesions, was used in 16.3% of the procedures. The in-hospital rate of major adverse cardiac events was 1.8%. At 6 months, the rate was 18.7%. Angiographic follow-up was available for 70.4% of the patients. Nonocclusive restenosis was seen in 18.8% and total occlusion in 5.7% of patients. A combined end point for late (30–180 days) definitive or suspected target vessel closure was reached in 5.4%, but with only 2% of clinical events. Multivariate analysis was performed for major adverse cardiac events and late thrombosis. Conclusion: Data obtained from the multicenter RENO registry study, derived from a large cohort of unselected consecutive patients, suggest that the good results of recent randomized controlled clinical trials can be replicated in routine clinical practice. © 2003 Elsevier Science Inc. [less ▲]

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See detailChronique de la 55ème Session de la SIHDA à Rotterdam (18-22 Septembre 2001)
Gerkens, Jean-François ULiege

in Revue Internationale des Droits de l'Antiquité (2003), L

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See detailA survey of proposals for an alternative group communication service
El-Sayed, A.; Roca, V.; Mathy, Laurent ULiege

in IEEE Network (2003), 17(1), 46--51

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See detailIn memoriam Roger Vigneron
Gerkens, Jean-François ULiege

in Revue Internationale des Droits de l'Antiquité (2003), L

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See detailTrophic habits and aquatic microhabitat use in gilled immature, paedomorphic and metamorphic Alpine newts (Triturus alpestris apuanus) in a pond in central Italy
Denoël, Mathieu ULiege; Andreone, F.

in Belgian Journal of Zoology (2003), 133(2), 95-102

Current evolutionary models suggest that the presence of heterogeneous habitats favours the evolution of polymorphisms. In such cases, alternative phenotypes can coexist because they use different ... [more ▼]

Current evolutionary models suggest that the presence of heterogeneous habitats favours the evolution of polymorphisms. In such cases, alternative phenotypes can coexist because they use different resources. Facultative paedomorphosis is a heterochronic polymorphism in which a morph - the paedomorph - retains larval traits during the adult stage while the other morph - the metamorph - is fully metamorphosed. The aim of this study was to determine the microhabitat use and the diet of Alpine newt paedomorphs, metamorphs and immatures (Triturus alpestris apuanus) coexisting in a small pond in Tuscany, central Italy, i.e. in a habitat where dimorphism is not expected. Although the two adult morphs do not use exactly the same resources, resource partitioning was weaker than in deep Alpine lakes. Nevertheless, the diet of immature gilled newts (larvae) differed from that of adults (metamorphs and paedomorphs). While the larvae eat a large number of planktonic organisms, the adults focus on insect larvae and newt eggs. The differences in resource use favour the coexistence of aquatic juveniles and adults. In the studied pond, facultative paedomorphosis was previously shown to be favoured by a precocious maturity of the paedomorphs. This study shows that the coexistence of paedomorphs and metamorphs may also be supported by some dietary and spatial segregation, although any advantages gained by this pattern are rather limited in the adult stage. [less ▲]

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See detailChronique de la 57ème Session de la SIHDA à Clermont-Ferrand (16-20 Septembre 2003)
Gerkens, Jean-François ULiege

in Revue Internationale des Droits de l'Antiquité (2003), L

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See detailA conceptual framework to design and support self-directed learning in a blended learning program. A case-stydy: the DES-TEF
Denis, Brigitte ULiege

in Journal of Educational Media (2003), 28(2-3), 115-127

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of ... [more ▼]

This paper relates different strategies developed in order to support the learning process in a blended learning programme involving adults from different backgrounds who are interested in the use of Information and Communication Technologies for Education (ICTE). Referring to Carré & Pearn’s model of the seven pillars of self-learning, the author describes some principles, tools and resources that have been developed within the framework of a postgraduate diploma and that could be extended to similar adult training programmes. [less ▲]

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See detailCompte-rendu de l'ouvrage de Pascal Deloge: Une coopération difficile : Belgique et Grande-Bretagne en quête de sécurité à l’aube de la guerre froide
Lanneau, Catherine ULiege

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2003), XXV(1), 19-20

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See detailFunctional identification of epithelial and smooth muscle histamine-dependent relaxing mechanisms in the bovine trachea, but not in bronchi
Jolly, Sandra ULiege; Desmecht, Daniel ULiege

in Comparative Biochemistry & Physiology Part C : Toxicology & Pharmacology (2003), 134(1), 91-100

Theoretically, the overall effect of histamine on respiratory smooth muscle is the result of a subtle balance of contraction and relaxation. The aim of the study was to identify histamine type 2 (H2) and ... [more ▼]

Theoretically, the overall effect of histamine on respiratory smooth muscle is the result of a subtle balance of contraction and relaxation. The aim of the study was to identify histamine type 2 (H2) and 3 (H3) receptor-dependent relaxing mechanisms in the contractile elements of the bovine tracheobronchial tree. In bronchial preparations, histamine induced very weak contractions, which were not exacerbated with the H2-antagonist cimetidine. Moreover, precontracted bronchial rings never relaxed in response to cumulative doses of histamine or amthamine (H2-agonist). In intact tracheal preparations, histamine induced strong contractions that were exacerbated by cimetidine (E-max : + 17.2 +/- 6.6%) but not by thioperamide (H3-antagonist). Precontracted tracheal bundles did not relax in response to cumulative doses of the H3-agonist R-alpha-methylhistamine. The tracheal contractile response was higher in denuded compared to intact preparations (11.0+/-1.2 vs. 6.0+/-1.7 g). Cimetidine effect was dramatically potentiated in denuded tracheal strips (+40.0+/-11.7%). It is concluded that the weak response. of bovine bronchi to histamine is due to a relative scarcity of H1 receptors on bronchial smooth muscle rather than to H2- or H3-dependent relaxation. In the bovine trachea, the smooth muscle possesses relaxing H2 but no H3 receptors. The epithelium exercises a relaxation, which is independent from H2 and H3 receptors. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailAutoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: A prospective cohort study
Vermeire, S.; Noman, M.; Van Assche, G. et al

in Gastroenterology (2003), 125(1), 32-39

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and ... [more ▼]

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and the relationship with autoimmunity have not been investigated. We investigated the occurrence of antinuclear antibodies in 125 consecutive Crohn's disease patients and studied the relationship with symptoms of autoimmunity. Methods: Autoantibodies and clinical data were investigated before and 1, 2, and 3 months after infliximab infusion. If antinuclear antibodies were greater than or equal to1:80, further study of double-stranded DNA, single-stranded DNA, histones, and ENA was performed. Results: Cumulative antinuclear antibody incidence at 24 months was 71 of 125 (56.8%). Almost half of these patients developed antinuclear antibodies after the first infusion, and >75% became antinuclear antibody positive after fewer than 3 infusions. So far, only :15 of 71 patients have become seronegative, after a median of 12 months. Of 43 antinuclear antibody-positive patients who were further subtyped, 14 of 43 (32.6%) had double-stranded DNA, 17 (39.5%) had single-stranded DNA, 9 (20.9%) had antihistone, and 0% were ENA positive. Two patients (both antihistone and double-stranded DNA positive) developed drug-induced lupus without major organ damage, and I developed autoimmune hemolytic anemia. Antinuclear antibodies were associated with the female sex (odds ratio, 3.166; 95% confidence interval, 1.167-8.585; P = 0.024) and with papulosquamous or butterfly rash (odds ratio, 10.016; 95% confidence interval, 1.708-58.725; P = 0.011). Conclusions: The cumulative incidence of antinuclear antibodies was 56.8% after 24 months in this cohort of infliximab-treated Crohn's disease patients. Antinuclear antibodies persisted up to I year after the last infusion, and only a few patients became seronegative. Two patients developed drug-induced lupus erythematosus. Antinuclear antibodies were associated with the female sex and skin manifestations. [less ▲]

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See detailDes statines pour le cerveau?
Sadzot, Bernard ULiege; HANS, Grégory ULiege; Bottin, P. et al

in Revue Médicale de Liège (2003), 58(10), 621-7

Whether cholesterol lowering decreases risk of stroke has long remained unclear. Large epidemiological studies have found only weak links between cholesterol levels and stroke. Recent studies with statins ... [more ▼]

Whether cholesterol lowering decreases risk of stroke has long remained unclear. Large epidemiological studies have found only weak links between cholesterol levels and stroke. Recent studies with statins, more potent cholesterol lowering agents, have now demonstrated significant reductions of stroke incidence and total mortality when administered for secondary prevention in patients with wide ranges of cholesterol values. It remains unknown if a statin is superior to others for the secondary prevention of stroke. [less ▲]

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See detailApplication of the fast multipole method to the 2D finite element-boundary element analysis of electromechanical devices
V Sabariego, Ruth ULiege; Gyselinck, J.; Geuzaine, Christophe ULiege et al

in COMPEL (2003), 22(3), 659-673

The present paper deals with the fast multipole acceleration of the 2D finite element-boundary element modelling of electromechanical devices. It is shown that the fast multipole method, usually applied ... [more ▼]

The present paper deals with the fast multipole acceleration of the 2D finite element-boundary element modelling of electromechanical devices. It is shown that the fast multipole method, usually applied to large 3D problems, can also lead to a reduction in computational time when dealing with relatively small 2D problems, provided that an adaptive truncation scheme for the expansion of the 2D Laplace Green function is used. As an application example, the 2D hybrid modelling of a linear actuator is studied, taking into account saturation, the voltage supply and the mechanical equation. The computational cost without and with fast multipole acceleration is discussed for both the Linear and nonlinear case. [less ▲]

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See detailXMM-Newton high-resolution X-ray spectroscopy of the Wolf-Rayet object WR25 (WN6ha+O4f)
Raassen, A. J. J.; van der Hucht, K. A.; Mewe, R. et al

in Advances in Space Research (2003), 32(6), 1161-1165

We report the analysis of the X-ray spectrum of the Wolf-Rayet star WR 25, observed by RGS and EPIC-MOS on board XMM-Newton. Temperatures up to 40 MK have been determined. Strong absorption, exceeding the ... [more ▼]

We report the analysis of the X-ray spectrum of the Wolf-Rayet star WR 25, observed by RGS and EPIC-MOS on board XMM-Newton. Temperatures up to 40 MK have been determined. Strong absorption, exceeding the value due to the Inter Stellar Medium (ISM) has been detected and assigned to the dense stellar wind. (C) 2003 COSPAR. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailVariations at different spatial scales of Posidonia oceanica (L.) Delile beds; effects on the physico-chemical parameters of the sediment
Gobert, Sylvie ULiege; Kyramarios, Michael; Lepoint, Gilles ULiege et al

in Oceanologica Acta (2003), 26(2), 199-207

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level ... [more ▼]

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level (100 m2). All the parameters studied, excepting the number of leaves, decrease according to the depth. The horizontal spatial variations (centrifuge and centripetal distributions) reach a maximum in the shallower areas. The analysis of the microstructures (m2) of the meadow has not allowed a relationship to be established between the spatial variations of the biometric parameters and the environmental factors in the sediment (pH, water and organic matter content, red-ox potential, nutrient content). The heterogeneity of the meadow in the Revellata Bay quite probably results from the internal shoot and rhyzome growth dynamics. <br />On the other hand, it appears that the presence of the prairie modifies the physical-chemical characteristics of the sediment. In fact, the sandy patches present different physical-chemical characteristics: lower organic matter, different granulometric and much higher interstitial water nutrient levels, as well as a higher pH and oxydo-reduction potential. [less ▲]

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See detailRecherche et dosage des résidus de DDT dans le sérum
Charlier, Corinne ULiege

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2003), 18

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See detailThe extraforaminal juxtafacet cyst as a rare cause of L5 radiculopathy: a case report.
Salmon, Bernard L; Deprez, Manuel ULiege; Stevenaert, Achille ULiege et al

in Spine (2003), 28(19), 405-7

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal ... [more ▼]

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal juxtafacet cysts develop most frequently at the dorsal aspect of the zygapophysial joint, sometimes in the posterolateral area of the canal. In one case, they have been described in the foraminal and extraforaminal region. METHODS: Description of the case report. RESULT: The authors report one case of a strictly extraforaminal juxtafacet cyst responsible for L5 sciatica. CONCLUSIONS: Juxtafacet cysts of the spine represent an infrequent cause of sciatica, usually when they grow in the canal, or more exceptionally when they occupy the foraminal or extraforaminal areas. [less ▲]

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See detailOptimisation du protocole GPG
Hanzen, Christian ULiege; Boudry, B.

in Point Vétérinaire (2003), 34(240), 44-46

Les facteurs susceptibles d’influencer les performances de reproduction permises par le protocole GPG sont multiples. L’apparition de l’oestrus et sa durée, la fréquence de l’ovulation, la croissance ... [more ▼]

Les facteurs susceptibles d’influencer les performances de reproduction permises par le protocole GPG sont multiples. L’apparition de l’oestrus et sa durée, la fréquence de l’ovulation, la croissance folliculaire, tout comme la progestéronémie, sont susceptibles d’être influencés par le stade du cycle auquel le protocole est mis en place. Le taux de gestation est d’autant plus élevé que la proportion d’animaux en anoestrus dans le troupeau est faible. Ceci explique sans doute en partie pourquoi la fertilité se trouve améliorée lorsque l’insémination suivant le traitement est effectuée après le 75e jour de lactation. De même, des résultats préliminaires confirment l’application potentielle du protocole au traitement des kystes ovariens. [less ▲]

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See detailStratégies thérapeutiques dans les adénomes somatotropes avec extension extrasellaire. Place du traitement médical. Etude consensus du Répertoire français de l'Acromégalie.
Jaquet, Ph; Cortet-Rudelli, Ch; Sassolas, G. et al

in Annales d'Endocrinologie (2003), 64(6), 434-441

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by ... [more ▼]

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by stereotactic or conventional radiotherapy. In these patients (including 37 women), aged 21-77 yr. (45.7 +/- 13.3), GH concentrations ranged from 2-260 microg/L (38.6 +/- 44.3), and IGF I from 86-967% of age-matched upper limit of normal (303 +/- 164). Maximal diameter of the adenoma at MRI was 11-36.5 mm (20.4 +/- 6.5), with cavernous sinus involvement in 68% of cases. Three subgroups were defined: 20 patients treated by long-acting somatostatin analogs only (group M), for a mean duration of 3 yr. (extremes 1-7 yr.), 48 patients initially treated by transsphenoidal surgery (group C), of whom 21 were secondarily treated by long-acting somatostatin analogs (group CM) for a mean duration of 1.2 yr. (extremes 0.2-2 yr.). All 3 groups were not statistically different in terms of tumor mass and initial levels of GH and IGF-1. Patients from group M were significantly older than those of the other groups (p<0.05). RESULTS: 46% of patients from group C after surgery vs. 45% of patients from group M had a mean GH below 2.5 microg/L. Biochemical remission (GH<2.5 microg/L and normal IGF1 normal) was obtained in 31% of cases in group C, vs. 25% in group M. In this group, a decrease of the largest tumor diameter was observed in 10 patients (71.5%), ranging from 10-25% in 7 (50%) and exceeded 50% in 3 (21.5%). In group CM, the biochemical remission rate (42%) and final GH or IGF1 values were not significantly different from group M. In conclusion, these data suggest that surgery or long-acting somatostatin analogs have a comparable efficacy in terms of remission rates in somatotroph macroadenomas with extrasellar extensions. [less ▲]

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See detailPreschoolers' use of form class cues to learn descriptive proper names
Hall, D. G.; Waxman, S. R.; Brédart, Serge ULiege et al

in Child Development (2003), 74(5), 1547-1560

This study examined 3- and 4-year-old preschoolers' ability to learn proper names containing familiar descriptions. Children saw a novel creature with a familiar property (it was red) and heard either an ... [more ▼]

This study examined 3- and 4-year-old preschoolers' ability to learn proper names containing familiar descriptions. Children saw a novel creature with a familiar property (it was red) and heard either an adjective ("This is a red one") or a descriptive proper name ("This is Mr. Red"). The creature was then transformed, losing the property (e.g., it became green). Children had to extend the word to either the transformed original creature or a new creature bearing the original property (another red creature). Children, especially 4-year-olds, extended the adjective to the new creature but were significantly more likely to extend the proper name to the original creature. Lexical form class cues provided potent information about word meaning, directing preschoolers to reinterpret familiar descriptive terms (adjectives) as homophonic terms designating unique individuals (proper names). [less ▲]

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See detailElectrophysiological studies in migraine: a comprehensive review of their interest and limitations
Ambrosini, Anna; Maertens De Noordhout, Alain ULiege; Sandor, P. et al

in Cephalalgia : An International Journal of Headache (2003), 23(Suppl. 1), 13-31

Electrophysiological methods may help to unravel some of the pathophysiological mechanisms of migraine. Lack of habituation is the principal and most reproducible interictal abnormality in sensory ... [more ▼]

Electrophysiological methods may help to unravel some of the pathophysiological mechanisms of migraine. Lack of habituation is the principal and most reproducible interictal abnormality in sensory processing in migraineurs. It is found in evoked potential (EP) studies for every stimulation modality including nociceptive stimuli, and it is likely to be responsible for the increased intensity dependence of EP. We have hypothesized that deficient EP habituation in migraine could be due to a reduced preactivation level of sensory cortices because of hypofunctioning subcortico-cortical aminergic pathways. This is not in keeping with simple hyperexcitability of the cortex, which has been suggested by some, but not all, studies of transcranial magnetic stimulation (TMS). A recent study of the effects of repetitive TMS on visual EP strongly supports the hypothesis that migraine is characterized by interictal cortical hypoexcitability. With regard to pain mechanisms in migraine, electrophysiological studies of trigeminal pathways using nociceptive blink and corneal reflexes have confirmed that sensitization of central trigeminal nociceptors occurs during migraine attacks. [less ▲]

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See detailL'etude clinique du mois Quel antihypertenseur en premiere intention? Resultats de l'etude ALLHAT.
Scheen, André ULiege; Krzesinski, Jean-Marie ULiege

in Revue Médicale de Liège (2003), 58(1), 47-52

Antihypertensive therapy is well established to reduce hypertension-related morbidity and mortality, but the optimal first-step therapy is still controversial. The "Antihypertensive and Lipid-Lowering ... [more ▼]

Antihypertensive therapy is well established to reduce hypertension-related morbidity and mortality, but the optimal first-step therapy is still controversial. The "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial" (ALLHAT) should give such an answer. It is a randomised, double-blind, trial designed to determine whether treatment with either a calcium channel blocker or an angiotensin-converting enzyme inhibitor lowers the incidence of coronary heart disease (CHD) or other cardiovascular disease (CVD) events vs treatment with a diuretic. A total of 33,357 participants aged 55 years or older with mild to moderate hypertension and at least 1 other CHD risk factor were randomly assigned to receive chlorthalidone (12.5 to 25 mg/day; n = 15,255), amlodipine (2.5 to 10 mg/day; n = 9,048) or lisinopril (10 to 40 mg; n = 9,054). The primary outcome combined both fatal CHD and non-fatal myocardial infarction, analyzed by intent-to-treat. Secondary outcomes were all-causes mortality, stroke, combined CHD (primary outcome, coronary revascularization, or angina with hospitalization), and combined CVD (combined CHD, stroke, treated angina without hospitalization, heart failure and peripheral arterial disease). Chlorthalidone was slightly more effective in reducing systolic pressure while amlodipine reduced slightly more effectively diastolic blood pressure. After a mean follow up of 4.9 years, no differences were observed between the three treatments regarding both the primary outcome and the total mortality. Secondary outcomes were similar when comparing amlodipine vs chlorthalidone. A moderately higher 6-year incidence rate of clinically detected heart failure was observed with amlodipine, but without significant influence on mortality. For lisinopril vs chlorthalidone, lisinopril had slightly higher 6-year rates of combined CVD, stroke and heart failure. In conclusion, thiazide-type diuretics are superior in preventing one or more major forms of CVD and offer the advantage to be cheaper. They should be preferred for first-step antihypertensive therapy. However, to reach the recommended blood pressure target, most patients should receive a combination of antihypertensive compounds. Such a combination should always comprise a diuretic agent, in absence of contra-indications. [less ▲]

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See detailStandardized test mixture for the characterization of comprehensive two-dimensional gas chromatography columns: the Phillips mix
Dimandja; Clouden; Colon et al

in Journal of Chromatography. A (2003), 1019

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See detailComment je traite ... une hypertrichose.
Pierard, Claudine ULiege; Henry, Frédérique ULiege; Paquet, Philippe ULiege et al

in Revue Médicale de Liège (2003), 58(10), 605-10

Hypertrichosis can result from various origins and exhibit diverse clinical presentations. Any etiological treatment, when available, does not always lead to regression of the excess in pilosity. Most ... [more ▼]

Hypertrichosis can result from various origins and exhibit diverse clinical presentations. Any etiological treatment, when available, does not always lead to regression of the excess in pilosity. Most often, hypertrichosis represents a real esthetic burden and affects the patient's self-esteem. Currently the laser epilation technique offers new and promising therapeutic possibilities. [less ▲]

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See detailMechanisms underlying the toxicity of lactone aroma compounds towards the producing yeast cells
Aguedo, Mario ULiege; Beney, L.; Waché, Y. et al

in Journal of Applied Microbiology (2003), 94(2), 258-265

Aims: To study the fundamental mechanisms of toxicity of the fruity aroma compound γ-decalactone, that lead to alterations in cell viability during its biotechnological production by yeast cells; Yarrowia ... [more ▼]

Aims: To study the fundamental mechanisms of toxicity of the fruity aroma compound γ-decalactone, that lead to alterations in cell viability during its biotechnological production by yeast cells; Yarrowia lipolytica that is able to produce high amounts of this metabolite was used here as a model. Methods and Results: Lactone concentrations above 150 mg l-1 inhibited cell growth, depolarized the living cells and increased membrane fluidity. Infrared spectroscopic measurements revealed that the introduction of the lactone into model phospholipid bilayers, decreased the phase transition temperature. Moreover, the H+-ATPase activity in membrane preparations was strongly affected by the presence of the lactone. On the other hand, only a slight decrease in the intracellular pH occurred. Conclusions: We propose that the toxic effects of γ-decalactone on yeast may be initially linked to a strong interaction of the compound with cell membrane lipids and components. Significance and Impact of the Study: These findings may enable the elaboration of strategies to improve yeast cell viability during the process of lactones bioproduction. [less ▲]

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See detailComment j'explore ... les secrets d'une meta-analyse.
Scheen, André ULiege

in Revue Médicale de Liège (2003), 58(1), 41-6

Meta-analysis is becoming a key partner of Evidence-Based Medicine. This statistical tool is currently used in most systematic reviews and allows to quantitatively synthesize the results of several ... [more ▼]

Meta-analysis is becoming a key partner of Evidence-Based Medicine. This statistical tool is currently used in most systematic reviews and allows to quantitatively synthesize the results of several studies by a single weighted average whose precision is indicated by the confidence interval. A standardized graphical representation allows, at first glance, to derive a lot of useful information, especially the number of studies taken into account for the analysis, the mean effect observed in each study with its confidence interval, the relative size (number of subjects) of each study, the homogeneity/heterogeneity of between-study results, finally the overall mean effects with its confidence interval. The meta-analysis plays a key-role in epidemiology, for the evaluation of a risk or a protective factor, and in therapeutics, for summarizing the results of numerous clinical trials with a specific drug or a pharmacological class in a given disease. [less ▲]

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See detailOptimization, continuation and lack of the one-step diphosphorylation reaction. Assay of modification of the tetraethyl(pyrrolidine-2,2-diyl)bisphosphonate
Olive, Gilles ULiege; Jacques, Alain

in Phosphorus, Sulfur & Silicon & the Related Elements (2003), 178(1), 33-46

The optimization of the one-step diphosphorylation reaction is reported. The synthesis of new ®-aminobisphosphonates with four- and sixmembered rings and acyclic species with several substituents on the ... [more ▼]

The optimization of the one-step diphosphorylation reaction is reported. The synthesis of new ®-aminobisphosphonates with four- and sixmembered rings and acyclic species with several substituents on the nitrogen atom and on the carbon atom bearing the two phosphorus atoms is described. [less ▲]

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See detailRestart of lignification in micropropagated walnut shoots coincides with rooting induction
Bisbis, Badia; Kevers, Claire ULiege; Crèvecoeur, Michèle et al

in Biologia Plantarum (2003), 47(1), 1-5

The lignin content of walnut shoots did not change during in vitro shoot Multiplication. Lignin content started to increase as soon as shoots were passed to a rooting medium with auxin. Exogenous auxin ... [more ▼]

The lignin content of walnut shoots did not change during in vitro shoot Multiplication. Lignin content started to increase as soon as shoots were passed to a rooting medium with auxin. Exogenous auxin (applied for rooting) Caused a transient elevation of the endogenous free indoleacetic acid (IAA) content with a Simultaneous decrease of peroxidase activity. These events typically marked the completion of the rooting inductive phase (before any visible histological event. that is before the cell divisions beginnin- the rootin- initiation phase). This meant that either the given exogenous auxin or the endogenous IAA has served as signal for the stimulation of lignification. Continued increase of lignification in the shoots required completion of root formation; this increase indeed was slown down when root emergence did not occur. It was further shown that lionification varied conversely to the content of the Soluble Phenol Content. itself apparently being related to the activity of phenylalanine ammonia-lyase activity. [less ▲]

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See detailAttitudes et controverses dans la prevention secondaire de l'accident ischemique cerebral.
HANS, Grégory ULiege; Sadzot, Bernard ULiege; Moonen, Gustave ULiege

in Revue medicale de Liege (2003), 58(5), 287-92

Stroke is the third leading cause of death and the main cause of prolonged disability of adults in industrialised countries. After a first transient ischemic attack or a first minor stroke, the risk of ... [more ▼]

Stroke is the third leading cause of death and the main cause of prolonged disability of adults in industrialised countries. After a first transient ischemic attack or a first minor stroke, the risk of recurrence is 16 folds higher than in control subjects. Therefore each patient suspect of a first ischemic cerebral event should be evaluated for the presence of a specific cause which could be treated. If such a cause is not found, platelet antiaggregant medications should be started. [less ▲]

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See detailA taxonomic reassessment of the Vittiaceae (Hypnales, Bryopsida):evidence from phylogenetic analyses of combined chloroplast and nuclear sequence data
Vanderpoorten, Alain ULiege; Goffinet, B.; Hedenäs, L. et al

in Plant Systematics & Evolution (2003), 241

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See detailvaria
Martiniello, Marco ULiege; Guillon, Michelle

in Revue Européenne des Migrations Internationales (2003), 19(1),

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