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See detailLigamentoplasties du genou: l'état musculaire préopératoire conditionne t il le degré d'amyotrophie postopératoire?
Croisier, Jean-Louis ULg; Delcour, J. P.; Crielaard, Jean-Michel ULg

in Annales de Réadaptation et de Médecine Physique (1994), 37

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See detailDe limite en frontière : le monde à la mesure de l'homme
Bachelet, Jean-François ULg

in Revue de l'Institut de Sociologie (1994), 3-4

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See detailBrucellose enzootique à Brucella suis biotype 2 chez le sanglier (sus scrofa) en Belgique
Godfroid, J.; Michel, P.; Uytterhaegen, L. et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailHereditary muscular hypertrophy in cattle is associated with a reduced myocardial contractility
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailAsthme et hyperréactivité bronchique non spécifique
Louis, Renaud ULg; Kayembe, J. M.; Radermecker, Maurice ULg

in Acta Clinica Belgica (1994), 49(3-4), 148-57

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes ... [more ▼]

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes modifying the functional status of airway smooth muscle as well as the structure of the bronchial wall. The responsiveness toward a direct constricting pharmacological agent is poorly correlated to the one toward an indirect constricting agent or a physical stimulus which cause airway obstruction through a more complex mechanism. Transversal studies show a relationship between the severity of asthma and the level of methacholine airway responsiveness. Long term treatment with corticoids can reduce the bronchial hyperresponsiveness of asthmatics. [less ▲]

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See detailExpression and function of DRC-1 antigen.
Bosseloir, A. L.; Antoine, Nadine ULg; Heinen, Ernst ULg et al

in Advances in Experimental Medicine and Biology (1994), 355

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See detailAnti-LFA-1 (CD11a) monoclonal antibody interferes with the induction of neonatal tolerance to alloantigens
Schurmans, Stéphane ULg; Gonzalez, A.; Revilla, C. et al

in European Journal of Immunology (1994), 24

The injection of (C57BL/6 x BALB/c)F1 spleen cells into newborn BALB/c mice results in the induction of a specific cytotoxic T lymphocyte (CTL) tolerance to the alloantigens. On the contrary, alloreactive ... [more ▼]

The injection of (C57BL/6 x BALB/c)F1 spleen cells into newborn BALB/c mice results in the induction of a specific cytotoxic T lymphocyte (CTL) tolerance to the alloantigens. On the contrary, alloreactive CD4+ T cells persist in the host and are still able to activate autoreactive F1 B cells to produce autoantibodies. This state of "split tolerance" is closely associated with the development of a lupus-like autoimmune syndrome. The LFA-1 integrin plays a relevant role in homing, intercellular adhesion and tranduction of co-stimulatory signals in leukocytes. Because of the beneficial effects of anti-LFA-1 monoclonal antibodies (mAb) treatment in various models of organ transplantation and autoimmune disease, we have investigated if such a treatment could interfere with the induction of neonatal tolerance or the development of the autoimmune syndrome in F1 cell-injected newborn mice. For this purpose, BALB/c mice neonatally injected with F1 cells were treated from day 1 up to day 15 with a non-cytotoxic anti-LFA-1 (CD11a) mAb. Anti-LFA-1 mAb treatment interfered with the persistence of a stable chimerism and with the establishment of CTL tolerance, as shown by rejection of allogeneic skin grafts and F1 B cells, and by a normal in vitro CTL activity against the corresponding alloantigens. As a consequence, these mice did not develop the characteristic autoimmune features seen in close association with an effective induction of CTL tolerance to alloantigens. These results stress the importance of the interactions between LFA-1 and its ligands during the neonatal induction of tolerance to alloantigens [less ▲]

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See detailThe 4s-4p Transitions in Neutral Phosphorus
Biémont, Emile ULg; Martin, F.; Quinet, Pascal ULg et al

in Astronomy and Astrophysics (1994), 283

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See detailReasoning about Infinite Computations
Vardi, Moshe Y.; Wolper, Pierre ULg

in Information & Computation (1994), 115(1), 1-37

We investigate extensions of temporal logic by connectives defined by finite automata on infinite words. We consider three different logics, corresponding to three different types of acceptance conditions ... [more ▼]

We investigate extensions of temporal logic by connectives defined by finite automata on infinite words. We consider three different logics, corresponding to three different types of acceptance conditions (finite, looping, and repeating) for the automata. It turns out, however that these logics all have the same expressive power and that their decision problems are all PSPACE-complete. We also investigate connectives defined by alternating automata and show that they do not increase the expressive power of the logic or the complexity of the decision problem. (C) 1994 Academic Press, Inc. [less ▲]

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See detailCrystallization and X-ray diffraction study of the Streptomyces K15 penicillin-binding DD-transpeptidase.
Englebert, S.; Charlier, Paulette ULg; Fonze, E. et al

in Journal of Molecular Biology (1994), 241(2), 295-7

The 262 amino acid residue long DD-transpeptidase/penicillin-binding protein of Streptomyces K15 has been crystallized at room temperature by using the hanging drop vapour diffusion technique. The ... [more ▼]

The 262 amino acid residue long DD-transpeptidase/penicillin-binding protein of Streptomyces K15 has been crystallized at room temperature by using the hanging drop vapour diffusion technique. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a = 46.4 A, b = 54.1 A and c = 108.3 A. They contain one protein molecule per asymmetric unit and diffract to about 1.9 A. X-ray data have been collected to 2.0 A from a native crystal. The previously published amino acid sequence of the protein has been corrected at positions 71, 72, 113, 114 and 156. [less ▲]

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See detailQuelle stratégie pour le développement rural dans la structuration de l'espace régional?
Rondeux, Jacques ULg

in Annales de Gembloux (1994), 100(3-4), 93-107

L’espace rural comporte tellement de paramètres et de diversités et vit aujourd’hui tellement de mutations que le définir de manière précise est une gageure. On pourrait dire qu’il concerne un territoire ... [more ▼]

L’espace rural comporte tellement de paramètres et de diversités et vit aujourd’hui tellement de mutations que le définir de manière précise est une gageure. On pourrait dire qu’il concerne un territoire essentiellement agricole, à contours diffus, caractérisé par une grande diversité où l’homme y voit une source d’activités multiples, saisonnières ou complémentaires, de services gratuits et de ressources renouvelables : l’air, l’eau, le paysage. Ce n’est pas la ville, ce n’est pas le site industriel mais cela peut être les champs entre deux agglomérations, la forêt entre deux villes et surtout les grands espaces, le monde ouvert dans lequel on oublierait un peu vite que pour maintenir son originalité et valoriser ses atouts et donc se développer il doit se raccrocher à des villes, chacun tirant profit des spécificités et des potentialités de l’autre. Non au désert économique, non aux services systématiquement gratuits, non à l’absence de tissu urbain adapté ; voilà les conditions pour le maintien ou pour un oui à une agriculture revue et corrigée, à la qualité de la vie, à la beauté des paysages, aux espaces de liberté et de détente, en un mot à une nouvelle ruralité basée sur la solidarité. [less ▲]

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See detailOn destabilizing implicit factors in discrete advection-diffusion equations
Beckers, Jean-Marie ULg

in Journal of Computational Physics (1994), 111(2), 260-265

In the present paper, we find necessary and sufficient stability conditions for a simple one-time step finite difference discretization of an N-dimensional advection-diffusion equation. Furthermore, it is ... [more ▼]

In the present paper, we find necessary and sufficient stability conditions for a simple one-time step finite difference discretization of an N-dimensional advection-diffusion equation. Furthermore, it is shown that when the implicit factors differ in each direction, a strange behavior occurs: By increasing one implicit factor in only one direction, a stable scheme can become unstable. It is thus suggested to use a single implicit direction (for efficient computing), or the same implicit factor in each direction. (C) 1994 Academic Press, Inc. [less ▲]

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See detailShape processing and analysis using the calypter
Pirard, Eric ULg

in Journal of Microscopy (1994), 175(3), 214-221

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See detailMR1325693,Huang, Hou-Cheng and Usmani, Asif S.,Finite element analysis for heat transfer
Rochus, Pierre ULg

in Mathematical Reviews [=MR] (1994)

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See detailTHE BLOOD PROTEINS OF THE ANTARCTIC ICEFISH CHANNICHTHYS-RHINOCERATUS - BIOLOGICAL SIGNIFICANCE AND PURIFICATION OF THE 2 MAIN COMPONENTS
Feller, Georges ULg; Poncin, A.; Aittaleb, M. et al

in Comparative Biochemistry and Physiology. B : Comparative Biochemistry (1994), 109(1), 89-97

The lack of hemoglobin and of carbonic anhydrase in the blood of icefish suggest that substantial adaptations of the acid-base balance should occur in order to ensure blood pH homeostasis. The level of ... [more ▼]

The lack of hemoglobin and of carbonic anhydrase in the blood of icefish suggest that substantial adaptations of the acid-base balance should occur in order to ensure blood pH homeostasis. The level of peptidic histidyl and of reactive -SH groups per unit of body mass in icefish plasma are 12-13 times higher that those of Notothenia rossii, a common red-blooded Antarctic species. It is proposed that the high level of imidazole ring in icefish plasma improves the non-bicarbonate buffering capacity and that the reactive sulfhydryls are involved om a redox buffer as in some other hypoxia tolerant species. After plasma fractionation on Ultrogel AcA 34, the two main icefish serum proteins have been purified by DEAE cellulose chromatography (IFI) and by HPLC on anion exchange column (IF2). IFI has been identified as a cysteine-rich para-albumin and IF2 as an histidine-rich immunoglobulin-like protein. [less ▲]

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See detailRécidive post-opératoire de la maladie de Crohn après chirurgie curatrice
Belaiche, Jacques ULg; Louis, Edouard ULg

in Médecine et Hygiène (1994), 52

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See detailEvolutionary affiliation of the marine nitrogen-fixing cyanobacterium Trichodesmium sp. strain NlBB 1067, derived by 16s ribosomal RNA sequence analysis
Wilmotte, Annick ULg; Neefs, Jean-Marc; De Wachter, Rupert

in Microbiology (1994), 140

The 165 rRNA sequence of Trichodesmium sp. strain NlBB 1067 was determined and used for the construction of a distance tree and bootstrap analysis. The tree shows that, among the available cyanobacterial ... [more ▼]

The 165 rRNA sequence of Trichodesmium sp. strain NlBB 1067 was determined and used for the construction of a distance tree and bootstrap analysis. The tree shows that, among the available cyanobacterial 165 rRNA sequences, Trichodesmium NlBB 1067 has Oscillatoria PCC 7515 as its closest relative, presenting 94.9% of sequence similarity with the latter strain. This is in contrast to a difference of 9 mol O/O G + C in mean genomic DNA base composition between the two organisms. Nevertheless, the genotypic heterogeneity presented by a number of strains assigned to the genus Oscillatoria hinders a taxonomic decision on the separate existence of the genera Trichodesmium and Oscillatoria. The sequence of the internal transcribed spacer (ITS) between the 165 and 23s rRNA genes was also determined, as a possible marker to study inter- and intraspecif ic variability. The ITS contains the genes coding for tRNA1Ie and tRNAAia and its total length is 547 nucleotides. In six out of eight sequenced clones, there is a duplication of 29 nucleotides, surrounding the 5' end of the tRNA1Ie. [less ▲]

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See detailModélisation mathématique appliquée à la délimitation des zones de protection: cas du site de captage de Vivegnis (plaine alluviale de la Meuse, Belgique)
Derouane, Johan; Dassargues, Alain ULg

in Bulletin du Centre d'Hydrogéologie de l'Université de Neuchätel (Suisse) (1994), 13

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See detailComparison of 125I and 3H testosterone radioimmunoassay methods in bovine serum
Miklos, M.; Renaville, Robert ULg; Tözser, J.

in Klin Kiserl Lab Med (1994), 22

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See detailCationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets
Antoine, M.-H.; Pirotte, Bernard ULg; Hermann, M. et al

in Experientia (1994), 50

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See detailSocio-prévention du hooliganisme et extrémisme dans le football
Comeron, Manuel ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994), 70

Etude de la problématique du racisme dans les stades de football et analyse de l'extrémisme politique des supporters

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See detailHST-FOC observations of a remarkable UV auroral event on Jupiter
Gérard, Jean-Claude ULg; Grodent, Denis ULg; Prangé, R. et al

in NASA STI/Recon Technical Report N (1994), 95

Two sets of UV (ultraviolet) images of the Jovian north aurora were obtained with the Faint Object Camera (FOC) on Hubble. The first series shows a very intense discrete arc in corotation with the planet ... [more ▼]

Two sets of UV (ultraviolet) images of the Jovian north aurora were obtained with the Faint Object Camera (FOC) on Hubble. The first series shows a very intense discrete arc in corotation with the planet. The maximum apparent H2 emission rate corresponds to an electron precipitation of approximately 1/sq Wm, a very large flux in comparison with the solar EUV (extreme ultraviolet) heating. The hugh particle heating rate of the auroral upper atmosphere of Jupiter is expected to cause a large transient temperature increase and generate strong thermospheric winds. Twenty hours later, the discrete arc had considerably decreased in brightness. The timescale and magnitude of the change in the UV aurora strongly suggests that the discrete Jovian auroral precipitation is related to large scale current system variations as are the Earth's discrete aurorae. [less ▲]

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See detailThe use of large scale computer assisted tomography for the study of hydrodynamics in trickling filters
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Chemical Engineering Science (1994), 49(24B), 5271-5280

In this paper, a new experimental technique is proposed, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling filters. Tomography refers to the cross ... [more ▼]

In this paper, a new experimental technique is proposed, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling filters. Tomography refers to the cross-sectional imaging of an object from data collected by illuminating this object from many directions. The experimental set-up allows the scanning of transverse sections of rather large filters: up to 0.8 m diameter and 2 m height can be irradiated. Experiments were carried out both without and with liquid flow. In the absence of liquid, the reconstructed images give a view of the non-uniformity of the solid phase distribution. The images obtained are very complex because they result from the superposition of several distributions with different spatial scales. The existence of a first spatial scale is shown which allows separation of the properties belonging to the individual packing elements from those belonging to the bed scale. When liquid is flowing through the packed bed, the distribution of the liquid hold-up is clearly evidenced, despite the very low liquid film thickness. [less ▲]

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See detailNew Energy Levels in Ne II deduced from FTS spectra in the Infrared Region (1800-9000 cm-1)
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg

in Physica Scripta (1994), 49

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See detailModulatory Effect of Neuropeptide Y on Acetylcholine-Induced Oedema and Vasoconstriction in Isolated Perfused Lungs of Rabbit
Delaunois, Annie ULg; Gustin, Pascal ULg; Dessy-Doize, C. et al

in British Journal of Pharmacology (1994), 113(3), 973-81

1. The modulatory role of neuropeptide Y (NPY) on pulmonary oedema induced by acetylcholine and capsaicin was investigated. The effects of NPY on the haemodynamic response to acetylcholine, phenylephrine ... [more ▼]

1. The modulatory role of neuropeptide Y (NPY) on pulmonary oedema induced by acetylcholine and capsaicin was investigated. The effects of NPY on the haemodynamic response to acetylcholine, phenylephrine and substance P were also investigated. 2. Isolated, ventilated, exsanguinated lungs of the rabbit were perfused with a constant flow of recirculating blood-free perfusate. The double/arterial/venous occlusion method was used to partition the total pressure gradient (delta Pt) into four components: the arterial gradient (delta Pa), the pre- and post-capillary gradients (respectively delta Pa' and delta Pv') and the venous pressure gradient (delta Pv). Endothelial permeability was evaluated by measuring the capillary filtration coefficient (Kf,c). 3. Acetylcholine (10(-8) M to 10(-4) M) and substance P (SP, 10(-10) M to 10(-6) M) induced a concentration-dependent increase in the Kf,c. Capsaicin (10(-4) M) and 5-hydroxytryptamine (5-HT) (10(-4) M) also increased this parameter. NPY (10(-8) M) completely inhibited the effects of acetylcholine and capsaicin on the Kf,c, without preventing the effects of substance P and 5-HT. 4. Acetylcholine induced concentration-dependent vasoconstriction in the precapillary segment. The effect was inhibited by NPY and aspirin, an inhibitor of cyclo-oxygenase, while ketanserin, a 5-HT2 receptor antagonist, and SR140333, a new NK1 antagonist, had no protective effect. Phenylephrine increased delta Pa at high concentration, an effect also inhibited by NPY and aspirin. Substance P had no significant haemodynamic effect. When injected together with NPY, substance P (10(-6) M) induced a significant increase in the total pressure gradient.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailChiral restoration transition in scaled effective Lagrangians
Jaminon, Martine ULg; Van den Bossche, Bruno

in Zeitschrift für Physik. C, Particles and Fields (1994), 64

We make a systematic study of the chiral restoration transition in function of the two free parameters of two scaled effective NJL Lagrangians. We show that it is not possible to reproduce with the same ... [more ▼]

We make a systematic study of the chiral restoration transition in function of the two free parameters of two scaled effective NJL Lagrangians. We show that it is not possible to reproduce with the same set of parameters the temperature behaviours of the quark condensate and of the quark entropy and a critical density at least equal to the normal density of nuclear systems. [less ▲]

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See detailPlace of MALT in the immune defence system.
Heinen, Ernst ULg

in Advances in Experimental Medicine and Biology (1994), 355

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See detailSpectrum analysis of diaphragmatic global electromyograms in cattle, with special regard to appropriate strategy for detection of fatigue.
Desmecht, Daniel ULg; Linden, Annick ULg; Close, R. P. et al

in American Journal of Veterinary Research (1994), 55

Although the respiratory tract of healthy and diseased cattle has been intensively studied during the past few years, only a few attempts to detect dysfunctions of bovine inspiratory muscles have been ... [more ▼]

Although the respiratory tract of healthy and diseased cattle has been intensively studied during the past few years, only a few attempts to detect dysfunctions of bovine inspiratory muscles have been reported. Such technique would be useful in assessing the possibility of inspiratory muscle fatigue in the context of ventilatory failure. Fatigue in skeletal muscle is associated with characteristic changes in the electromyographic power spectrum. Power spectral analysis was therefore applied to cattle diaphragmatic electromyograms (EMGdi) to precisely determine the exact influence of motion and ECG artifacts, describe its basic frequency content, and extract a spectral index capable of providing an accurate warning of fatigue. The EMGdi was recorded via intramuscularly placed fishhook electrodes in 5 healthy young bulls during resting and stimulated respiration. The EMGdi and EGC signals were analyzed by use of power spectral density analysis after band-pass filtering (20 to 1,800 Hz). The EMGdi spectrum was concentrated in the band width 20 to 530 Hz. Electrode motion artifacts were absent, and it was always possible to find an electrode pair giving ECG-free EMGdi. Of the 12 power and frequency values used to quantitate the spectrum, the most stable was the centroid frequency. It was reproducible within and between calves and was only minimally altered by changing inspiratory load.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailBiodegradation of the polycyclic aromatic hydrocarbons phenanthrene, naphtalene and biphenyl by bacteria isolated from a contaminated soil.
Detaille, D.; Jacques, Ph.; Thonart, Philippe ULg

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1994), 102(B8),

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See detailEffet du chargement et de la période de complémentation au pâturage sur les performances de taurillons finis en stabulation
Dufrasne, Isabelle ULg; Gielen, Marc ULg; Limbourg, Pierre et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailWanze/Huccorgne: Station de l'Hermitage
Noiret, Pierre ULg

in Chronique de l'Archéologie wallonne (1994), 2

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See detailVerticalization of behavior elicited by dopaminergic mobilization is qualitatively different between C57BL/6J and DBA/2J mice
Tirelli, Ezio ULg; Witkin, J. M.

in Psychopharmacology (1994), 116(2), 191-200

Behavioral effects of dopaminergic stimulation were compared for C57BL/6J mice and DBA/2J mice. Effects of apomorphine (APO) alone and in combination with cocaine (COC) were assessed using a time-sampling ... [more ▼]

Behavioral effects of dopaminergic stimulation were compared for C57BL/6J mice and DBA/2J mice. Effects of apomorphine (APO) alone and in combination with cocaine (COC) were assessed using a time-sampling technique that classified climbing and leaning in separate categories. Climbing occurred in DBA/2J mice only at doses of APO that were 16 times higher than the smallest effective dose in C57BL/6J mice, but relative to baseline values, effects were comparable. Whereas DBA/2J mice showed dose-dependent leaning under APO, C57BL/6J mice exhibited significantly increased leaning only after the highest APO dose. When given alone, COC produced significant climbing, but not leaning or gnawing, in either strain. COC potentiated APO-induced climbing and gnawing in both strains but did not consistently change APO-induced leaning in either strain. APO alone reduced locomotor activity and attenuated COC-induced hyperkinesia. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailMechanism of Thiamine Transport in Neuroblastoma Cells. Inhibition of a High Affinity Carrier by Sodium Channel Activators and Dependence of Thiamine Uptake on Membrane Potential and Intracellular Atp
Bettendorff, Lucien ULg; Wins, Pierre

in Journal of Biological Chemistry (1994), 269(20), 14379-14385

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a ... [more ▼]

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a saturable high affinity mechanism (Km = 35 nM). This was blocked by low concentrations of the Na+ channel activators veratridine (IC50 = 7 +/- 4 microM) and batrachotoxin (IC50 = 0.9 microM). These effects were not antagonized by tetrodotoxin and were also observed in cell lines devoid of Na+ channels, suggesting that these channels are not involved in the mechanism of inhibition. At high extracellular concentrations, thiamine uptake proceeds essentially via a low affinity carrier (Km = 0.8 mM), insensitive to veratridine but blocked by divalent cations. In both cases, the uptake was independent on external sodium, partially inhibited (10-35%) by depolarization and sensitive to metabolic inhibitors. A linear relationship between the rate of thiamine transport and intracellular ATP concentration was found. When cells grown in a medium of low thiamine concentration (6 nM) were exposed to 100 nM extracellular thiamine, a 3-fold increase in intracellular thiamine diphosphate was observed after 2 h while the concomitant increase in intracellular free thiamine was barely significant. These data suggest a secondary active transport of thiamine, the main driving force being thiamine phosphorylation rather than the sodium gradient. [less ▲]

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See detailConformal invariance and degrees of freedom in the QCD string
Dienes, Keith R; Cudell, Jean-René ULg

in Physical Review Letters (1994), 72

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See detailAvailability of glucose ingested during muscle exercise performed under acipimox-induced lipolysis blockade.
Gautier, J. F.; Pirnay, Freddy ULg; Jandrain, Bernard ULg et al

in European Journal of Applied Physiology and Occupational Physiology (1994), 68(5), 406-12

This study investigated the percentage of carbohydrate utilization than can be accounted for by glucose ingested during exercise performed after the ingestion of the potent lipolysis inhibitor Acipimox ... [more ▼]

This study investigated the percentage of carbohydrate utilization than can be accounted for by glucose ingested during exercise performed after the ingestion of the potent lipolysis inhibitor Acipimox. Six healthy male volunteers exercised for 3 h on a treadmill at about 45% of their maximal oxygen uptake, 75 min after having ingested 250 mg of Acipimox. After 15-min adaptation to exercise, they ingested either glucose dissolved in water, 50 g at time 0 min and 25 g at time 60 and 120 min (glucose, G) or sweetened water (control, C). Naturally labelled [13C]glucose was used to follow the conversion of the ingested glucose to expired-air CO2. Acipimox inhibited lipolysis in a similar manner in both experimental conditions. This was reflected by an almost complete suppression of the exercise-induced increase in plasma free fatty acid and glycerol and by an almost constant rate of lipid oxidation. Total carbohydrate oxidation evaluated by indirect calorimetry, was similar in both experimental conditions [C, 182, (SEM 21); G, 194 (SEM 16) g.3 h-1], as was lipid oxidation [C, 57 (SEM 6); G, 61 (SEM 3) g.3 h-1]. Exogenous glucose oxidation during exercise G, calculated by the changes in 13C:12C ratio of expired air CO2, averaged 66 (SEM 5) g.3 h-1 (19% of the total energy requirement). Consequently, endogenous carbohydrate utilization was significantly smaller after glucose than after placebo ingestion: 128 (SEM 18) versus 182 (SEM 21) g.3 h-1, respectively (P < 0.05). Symptoms of intense fatigue and leg cramps observed with intake of sweet placebo were absent with glucose ingestion.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Bouwen met Staal (1994), n°117

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See detailThe Compartmentation of Phosphorylated Thiamine Derivatives in Cultured Neuroblastoma Cells
Bettendorff, Lucien ULg

in Biochimica et Biophysica Acta (1994), 1222(1), 7-14

Thiamine transport in cultured neuroblastoma cells is mediated by a high-affinity carrier (KM = 40 nM). In contrast, the uptake of the more hydrophobic sulbutiamine (isobutyrylthiamine disulfide) is ... [more ▼]

Thiamine transport in cultured neuroblastoma cells is mediated by a high-affinity carrier (KM = 40 nM). In contrast, the uptake of the more hydrophobic sulbutiamine (isobutyrylthiamine disulfide) is unsaturable and its initial transport rate is 20-times faster than for thiamine. In the cytoplasm, sulbutiamine is rapidly hydrolyzed and reduced to free thiamine, the overall process resulting in a rapid and concentrative thiamine accumulation. Incorporation of radioactivity from [14C]thiamine or [14C]sulbutiamine into intracellular thiamine diphosphate is slow in both cases. Despite the fact that the diphosphate is probably the direct precursor for both thiamine monophosphate and triphosphate, the specific radioactivity increased much faster for the latter two compounds than for thiamine diphosphate. This suggests the existence of two pools of thiamine diphosphate, the larger one having a very slow turnover (about 17 h); a much smaller, rapidly turning over pool would be the precursor of thiamine mono- and triphosphate. The turnover time for thiamine triphosphate could be estimated to be 1-2 h. When preloading the cells with [14C]sulbutiamine was followed by a chase with the same concentration of the unlabeled compound, the specific radioactivities of thiamine and thiamine monophosphate decreased exponentially as expected, but labeling of the diphosphate continued to increase slowly. Specific radioactivity of thiamine triphosphate increased first, but after 30 min it began to slowly decrease. These results show for the first time the existence of distinct thiamine diphosphate pools in the same homogeneous cell population. They also suggest a complex compartmentation of thiamine metabolism. [less ▲]

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See detailL'hémorragie pulmonaire induite par l'exercise chez le cheval: une énigme de la médecine équine ?
Art, Tatiana ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1994), 138

This review analyses the epidemiology, etiology, anatomo- and physiopathology, diagnose and prevention of the syndrome of exercise pulmonary hemorrhage in horses

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See detailTechnical Study of Some Major Parameters Influencing the Performances of an Aerosol Delivery Equipment Suitable for Calves
Genicot, Bruno; Peckova, M.; Close, Roland et al

in Veterinary Research (1994), 25(5), 468-77

Aerosol delivery equipment, suitable for the treatment of bovine respiratory dysfunctions and including 2 parallelly positioned jet nebulizers, was studied in depth in order to determine the optimal ... [more ▼]

Aerosol delivery equipment, suitable for the treatment of bovine respiratory dysfunctions and including 2 parallelly positioned jet nebulizers, was studied in depth in order to determine the optimal working conditions in the field. Indeed, some factors might reasonably alter the performance of this equipment. Among these factors, the influences of the parallel position of jet nebulizers (in order to accommodate the breathing requirements of the cattle and achieve a rapid treatment), of the long feed pipe delivering compressed air (in order to keep the animal away from the compressor unit), and finally of the ambient temperature were studied, this equipment being essentially used during the winter season. This equipment could accommodate the breathing needs of cattle weighing up to 225 kg if a pressure of 600 kPa was developed upstream to the nebulizers. The rate of atomization was significantly reduced when working at ambient air temperatures (272.25 K < T < 274.65 K) close to those encountered in winter. This was especially true when pressure upstream to the nebulizers did not exceed 500 kPa. The immersion of the feed pipe for compressed air in hot water led to an increase in the rate of atomization without raising evaporative water losses, and reduced the drop in temperature in the nebulizer solution. Finally, the rate of atomization significantly increased when the face mask including the nebulizers was maintained so that the nebulizers were in a vertical position or at an angle not less than 60 degrees with respect to the ground. [less ▲]

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See detailHuman follicular dendritic cells in vitro
Tsunoda, R.; Heinen, Ernst ULg; Imai, Y. et al

in Dendritic Cells (1994), 4

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See detailLa Shoah ne fut pas un spectacle. A propos de La liste de Schindler
Delruelle, Edouard ULg

in Cahiers de Clio (1994), 117(11),

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See detailCo-movements and dynamic interrelationships in pacific basin stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza; Urbain, Jean-Pierre ULg

in Research in International Business and Finance (1994), 11B

In this paper, we investigate dynamic interrelationships among the stock markets of Australia, Hong Kong, Japan, New Zealand and Singapore. Using cointegration analysis and the Granger causality test we ... [more ▼]

In this paper, we investigate dynamic interrelationships among the stock markets of Australia, Hong Kong, Japan, New Zealand and Singapore. Using cointegration analysis and the Granger causality test we find that, although the five stock price indices share some common trends, the only stock price which does not apparently Granger cause (precede) the remaining stock prices is that of New Zealand. It is further observed that all price indices are caused by the remaining stock prices except that of Australia. With respect to the geographical separation, it appears that when we consider the Asian countries as an entity and those of the Pacific as another entity, they seem not to influence each other significantly. [less ▲]

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See detailStatistical properties of daily returns : evidence from european stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza

in Journal of Business Finance and Accounting (1994), 21(2), 271-282

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See detailA common system controls the induction of very different genes. The class-A beta-lactamase of Proteus vulgaris and the enterobacterial class-C beta-lactamase.
Datz, M; Joris, Bernard ULg; Azab, E A et al

in European Journal of Biochemistry (1994), 226(1), 149-57

Among the Enterobacteriaceae, Proteus vulgaris is exceptional in the inducible production of a 29-kDa beta-lactamase (cefuroximase) with an unusually high activity towards the beta-lactamase-stable ... [more ▼]

Among the Enterobacteriaceae, Proteus vulgaris is exceptional in the inducible production of a 29-kDa beta-lactamase (cefuroximase) with an unusually high activity towards the beta-lactamase-stable oximino-cephalosporins (e.g. cefuroxime and cefotaxime). Sequencing of the corresponding gene, cumA, showed that the derived CumA beta-lactamase belonged to the molecular class A. The structural gene was under the direct control of gene cumR, which was transcribed backwards and whose initiation codon was 165 bp away from that of the beta-lactamase gene. This resembled the arrangement of structural and regulator genes ampC and ampR of the 39-kDa molecular-class-C beta-lactamase AmpC present in many enterobacteria. Moreover, cloned genes ampD and ampG for negative modulation and signal transduction of AmpC beta-lactamase induction, respectively, were also able to restore constitutively CumA overproducing and non-inducible P. vulgaris mutants to the inducible, wild-type phenotype. The results indicate that controls of the induction phenomena are equivalent for the CumA and AmpC beta-lactamase. Very different structural genes can thus be under the control of identical systems. [less ▲]

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See detailQue peut-on attendre des marqueurs immunohistochimiques du mélanome?
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1994), 13

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See detailHeterogeneous conversion of N2O5 to HNO3 in the post-Mount Pinatubo eruption stratosphere
Rinsland, Curtis P.; Gunson, Michaël R.; Abrams, M. C. et al

in Journal of Geophysical Research (1994), 99(D4), 8213-8219

Simultaneous stratospheric volume mixing ratio (VMR) profiles of dinitrogen pentoxide (N2O5) and nitric acid (HNO3) at sunrise between 25-degrees-N and 15-degrees-S latitude and profiles of HNO3 at sunset ... [more ▼]

Simultaneous stratospheric volume mixing ratio (VMR) profiles of dinitrogen pentoxide (N2O5) and nitric acid (HNO3) at sunrise between 25-degrees-N and 15-degrees-S latitude and profiles of HNO3 at sunset between 42-degrees-S and 53-degrees-S latitude have been derived from 0.01 cm-1 resolution infrared solar occultation spectra recorded 9 1/2 months after the massive eruption of the Mount Pinatubo volcano in the Philippine Islands. The measurements were obtained by the atmospheric trace molecule spectroscopy (ATMOS) Fourier transform spectrometer during the ATLAS 1 shuttle mission (March 24 to April 2, 1992). The measured HNO3 VMRs are higher at all altitudes and latitudes than corresponding values measured by the limb infrared monitor of the stratosphere (LIMS) instrument during the same season in 1979, when the aerosol loading was near background levels. The largest relative increase in the HNO3 VMR occurred near the equator at 30-km altitude, where the ATMOS/ATLAS 1 values are about a factor of 2 higher than the LIMS measurements. Two-dimensional model calculations show that the increase in HNO3 and the ATMOS/ATLAS 1 measurement of a steep decrease in the N2O5 VMR below 30 km can be explained by the enhanced conversion of N2O5 to HNO3 on the surfaces of the Mount Pinatubo sulfate aerosols. Our profile results demonstrate the global impact of the N2O5 + H2O --> 2HNO3 heterogeneous reaction in altering the partitioning of stratospheric odd nitrogen after a major volcanic eruption. [less ▲]

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See detailC'est le bouquet... Histoire d'un ornement typographique liégeois du XVIIIe siècle
Droixhe, Daniel ULg

in Gutenberg-Jahrbuch (1994), 69

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See detailLa gestion des données avec le logiciel V. M. S.
Claustriaux, Jean-Jacques ULg; Deltenre, Alain

in Notes de Statistique et d'Informatique (1994), 2

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See detailA propos d'un cas de chylothorax compliquant une sclérose de varices oesophagiennes
Detry, Olivier ULg; Dekoster, Guy ULg; Honoré, Pierre ULg et al

in Lyon Chirurgical (1994), 90(1), 45-47

Chylothorax is an exceptional complication of endoscopic sclerotherapy of bleeding esophageal varices. We found only three cases in the literature. We report a fourth observation. We discuss the different ... [more ▼]

Chylothorax is an exceptional complication of endoscopic sclerotherapy of bleeding esophageal varices. We found only three cases in the literature. We report a fourth observation. We discuss the different etiologies and the different therapeutic approaches of these unusual chylothorax. [less ▲]

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See detailB.E.M.S. : Batterie d'Evaluation de la Morpho-Syntaxe : développement, évaluation, et lignes d'action
Fayasse, M.; Comblain, Annick ULg; Rondal, Jean-Adolphe ULg

in Informations pédagogiques (1994), 12

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See detailLes fleurs pâles du souvenir... Sur Guillaume Lekeu
Pirenne, Christophe ULg; Vendrix, Philippe ULg

in La Vie Wallonne (1994), 110

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See detailCARAIB - A global model of terrestrial biological productivity
Warnant, Pierre ULg; François, Louis ULg; Strivay, David ULg et al

in Global Biogeochemical Cycles (1994), 8(3), 255-270

CARAIB, a mechanistic model of carbon assimilation in the biosphere estimates the net primary productivity (NPP) of the continental vegetation on a grid of 1 degrees x 1 degrees in latitude and longitude ... [more ▼]

CARAIB, a mechanistic model of carbon assimilation in the biosphere estimates the net primary productivity (NPP) of the continental vegetation on a grid of 1 degrees x 1 degrees in latitude and longitude. The model considers the annual and diurnal cycles. It is based on the coupling of the three following submodels; a leaf assimilation model including estimates of stomatal conductance and leaf respiration, a canopy model describing principally the radiative transfer through the foliage, and a wood respiration model. Present-day climate and vegetation characteristics allow the discrimination between ecotypes. In particular, specific information on vegetation distribution and properties is successfully used at four levels; the leaf physiological level, the plant level, the ecosystem level, and the global level. The productivity determined by the CARAIB model is compared with local measurements and empirical estimates showing a good agreement with a global value of 65 Gt C yr(-1). The sensitivity of the model to the diurnal cycle and to the abundance of C-4 species is also tested. The productivity slightly decreases (10%) when the diurnal cycle of the temperature is neglected. By contrast, neglecting the diurnal cycle of solar irradiance produces unrealistically high values of NPP. Even if the importance of this increase would presumably be reduced by the coupling of CARAIB with a nutrient cycle model, this test emphasizes the key role of the diurnal cycle in a mechanistic model of the NPP. Uncertainties on the abundance and spatial distribution of C-4 plants may cause errors in the NPP estimates, however, as demonstrated by two sensitivity tests, these errors are certainly lower than 10% at the global scale as shown by two tests. [less ▲]

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See detailHamartome angiomateux eccrine néonatal en plaques plurifocales
Benzarti, H.; Fazaa, B.; Ben Hamida, H. et al

in Giornale Internazionale di Dermatologia Pediatrica (1994), 6(1), 15-17

We report a case of eccrine angiomatous hamartoma disclosed in a 5-year-old girl. The lesion was painful and multifocal in plaques on a forearm. The diagnosis was made on the basis of histologic and ... [more ▼]

We report a case of eccrine angiomatous hamartoma disclosed in a 5-year-old girl. The lesion was painful and multifocal in plaques on a forearm. The diagnosis was made on the basis of histologic and immunohistochemistric assays. This conditions must be distinguished from other neonatal angiomatoses. [less ▲]

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See detailChromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers
Cockett, N. E.; Jackson, S. P.; Shay, T. D. et al

in Proceedings of the National Academy of Sciences of the United States of America (1994), 91

A mutation causing muscular hypertrophy, with associated leanness and improved feed efficiency, has been recently identified in domestic sheep (Ovis aries). Preliminary results indicate that an autosomal ... [more ▼]

A mutation causing muscular hypertrophy, with associated leanness and improved feed efficiency, has been recently identified in domestic sheep (Ovis aries). Preliminary results indicate that an autosomal dominant gene may be responsible for this economically advantageous trait. We have exploited the conservation in sequence and chromosomal location of DNA markers across Bovidae to map the corresponding callipyge locus to ovine chromosome 18 using a battery of bovine chromosome 21 markers. Chromosomal localization of the ovine callipyge locus is the first step toward positional cloning of the corresponding gene. [less ▲]

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See detailENANTIOSELECTIVE SYNTHESIS OF NCA (S)-L-([ALPHA-C-11]METHYL)-TRYPTOPHAN
Plenevaux, Alain ULg; Lemaire, Christian ULg; Delfiore, Guy et al

in Applied Radiation & Isotopes (1994), 45(6), 651-653

N.c.a. (S)-L-([alpha-C-11]methyl)-tryptophan was prepared by treatment at -78-degrees-C of (2S,3aR,8aS)-1,2-bis(-methoxycarbonyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2, 3-b]-indole with lithium ... [more ▼]

N.c.a. (S)-L-([alpha-C-11]methyl)-tryptophan was prepared by treatment at -78-degrees-C of (2S,3aR,8aS)-1,2-bis(-methoxycarbonyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2, 3-b]-indole with lithium diisopropylamide and [C-11]CH3I. After hydrolysis with HI and HPLC purification, the title compound was isolated with a radiochemical yield of 36% (EOB corrected) within 22 min; e.e. was shown > 97% (n = 20); specific activity was ranging between 0.8 and 1.2 Ci (30-45 GBq)/mu mol EOB. [less ▲]

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See detailA Comparison of Cabergoline and Bromocriptine in the Treatment of Hyperprolactinemic Amenorrhea
Webster, J.; Piscitelli, G.; Polli, A. et al

in New England Journal of Medicine [=NEJM] (1994), 331(14), 904-909

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See detailUniversal scaling laws and the QCD scale anomaly
Ripka, Georges; Jaminon, Martine ULg

in Physics Reports (1994), 242

An effective chiral Lagrangian is given which implements the QCD scale anomaly and the universal scaling law of hadron masses. It is used to study the pion mass and the coupling between quark and gluon ... [more ▼]

An effective chiral Lagrangian is given which implements the QCD scale anomaly and the universal scaling law of hadron masses. It is used to study the pion mass and the coupling between quark and gluon condensates in dense matter. [less ▲]

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See detailTherapy for obesity--today and tomorrow.
Scheen, André ULg; Desaive, Claude ULg; Lefebvre, Pierre ULg

in Bailliere's Clinical Endocrinology and Metabolism (1994), 8(3), 705-27

Obesity poses a serious health hazard and its treatment is often disappointing. Besides conservative methods, the place of pharmacotherapy, very-low-calorie diets, and even, in selected cases, mechanical ... [more ▼]

Obesity poses a serious health hazard and its treatment is often disappointing. Besides conservative methods, the place of pharmacotherapy, very-low-calorie diets, and even, in selected cases, mechanical means or surgery can be considered. Effective drug treatment for obesity must reduce energy intake, or increase energy expenditure, or increase energy losses in faeces. All these possibilities have potential activities but also serious limitations. Current pharmacotherapy essentially uses anorectic drugs and the other approaches, although promising, are still under investigation. Of the anorectic compounds currently available, serotoninergic agents, like dexfenfluramine and fluoxetine, appear to have the most suitable pharmacological profile. Very-low-calorie diets could help in the short-term but should be associated with other approaches to increase the rate of long-term success. They must be well-balanced as macronutrients and micronutrients are concerned, be prescribed in well-selected patients under careful medical supervision, and not be followed longer than a few weeks. Surgery can provide palliation for severe obesity when all medical approaches have failed. It may consist in decreasing food intake (gastric procedures), affecting calorie absorption (intestinal shunting, biliopancreatic bypass), or removing localized excess fat (lipectomy, liposuction). Gastric reduction operations are safe and effective provided they are performed by experienced surgeons in well-selected patients. They can be considered now as the best option for a minority of patients with morbid and refractory obesity. Finally, in very selected patients, mechanical means (such as the waist cord) may also help losing weight and/or avoiding weight regain. Even if all these therapeutic approaches can be helpful, at least in some obese individuals, they also have important limitations so that prevention remains up to now the 'treatment' of choice for obesity. [less ▲]

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See detailBiostatistical studies of Western European allogamous populations of the Epipactis helleborine (L.) Crantz species group (Orchidaceae)
Tyteca, D.; Dufrêne, Marc ULg

in Systematic Botany (1994), 19(3), 424-442

[No abstract available]

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1994), 37

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair ... [more ▼]

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair haemodynamics in calves. Central venous, pulmonary arterial and capillary wedge and systemic arterial pressures were measured by fluid-filled catheters in 11 calves. Cardiac output was measured by the thermodilution technique, heart rate (HR) was derived from the ECG and stroke volume (SV), pulmonary and systemic vascular resistance were calculated. The haemodynamic values were measured hourly from the first to the tenth hour alter intratracheal inoculation of P. haemolytica. Cardiovascular response was marked and typically consisted of two hypotensive hypodynamic phases. The first, which occurred by the second hour after inoculation, consisted of a transient bradycardia and a systemic vasodilation leading to profound hypotension and reduced venous return. Cardiac performance then recovered, but systemic hypotension persisted and hypoxaemia developed. The second phase occurred by the seventh hour alter inoculation and was associated with a decline in SV, an increase in HR, and pulmonary hypertension. Three different degrees of cardiovascular dysfunctions were found, differing basically in the intensity of the first phase bradycardia and second phase reduction in SV and systemic arterial pressure, suggesting that experimental pneumonia produced by intratracheal instillation of P. haemolytica in calves results in distinct cardiovascular dysfunctions depending on the animal. Ignorance of the underlying haemodynamic status therefore precludes reliable interpretation of physiological as well as pharmacological results using this model of respiratory disease [less ▲]

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See detailThe coupling of quark and gluon condensates in hot and dense systems
Jaminon, Martine ULg; Van den Bossche, Bruno

in Nuclear Physics A (1994), 567

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See detailModeles lineaires en genetique quantitative: synthese des connaissances actuelles.
Gengler, Nicolas ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(1),

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See detailSTRUCTURAL AND KINETIC CHARACTERIZATION OF A BETA-LACTAMASE-INHIBITOR PROTEIN
STRYNADKA, N. C. J.; JENSEN, S. E.; JOHNS, K. et al

in Nature (1994), 368(6472), 657-660

THE past decade has seen an alarming worldwide increase in resistance to beta-lactam antibiotics among many pathogenic bacteria1, which is due mainly to plasmid- or chromosomally encoded beta-lactamases ... [more ▼]

THE past decade has seen an alarming worldwide increase in resistance to beta-lactam antibiotics among many pathogenic bacteria1, which is due mainly to plasmid- or chromosomally encoded beta-lactamases that specifically cleave penicillin and cephalosporins, rendering them inactive. There is therefore a need to develop new strategies in the design of effective inhibitors of beta-lactamase. All the small-molecule inhibitors in clinical use are not very effective and are rapidly degraded2,3. Furthermore, newly characterized mutants of the plasmid-mediated beta-lactamase TEM-1 are highly resistant to these small-molecule inhibitors, including clavulanic acid and tazobactam4. It has been shown that Streptomyces clavuligerus produces an exocellular beta-lactamase inhibitory protein (BLIP; M(r) 17.5 K)5. Here we present data defining BLIP as the most effective known inhibitor of a variety of beta-lactamases, with K(i) values in the subnanomolar to picomolar range. To identify those features in BLIP that make it such a potent inhibitor, we have determined its molecular structure at 2.1 angstrom resolution. BLIP is a relatively flat molecule with a unique fold, comprising a tandem repeat of a 76-amino-acid domain. Each domain consists of a helix-loop-helix motif that packs against a four-stranded antiparallel beta-sheet (Fig. 1a). To our knowledge, BLIP is the first example of a protein inhibitor having two similarly folded domains that interact with and inhibit a single target enzyme. [less ▲]

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See detailLa régression : un problème statistique complexe à partir d'une idée simple
Palm, Rodolphe ULg

in Biométrie-Praximétrie (1994), 34(2), 109-123

Comme beaucoup de domaines de la statistique, la régression a connu d'importants développements au cours de ces vingt-cinq dernières années et l'objectif de l'article est de présenter, de façon sommaire ... [more ▼]

Comme beaucoup de domaines de la statistique, la régression a connu d'importants développements au cours de ces vingt-cinq dernières années et l'objectif de l'article est de présenter, de façon sommaire, les développements relatifs à quelques aspects particuliers de la régression linéaire, même si certains éléments peuvent être facilement étendus ou adpatés au cas de la régression non linéaire. Nous examinerons tout d'abord le problème de la validation des résultats d'une régression, en considérant successivement les critères globaux de mesure de la qualité de la régression, la division des données et la validation croisée, les représentations graphiques et les mesures de l'influence. Ensuite, nous envisagerons l'établissement des équations de régression, en abordant le problème du choix des variables et en évoquant quelques alternatives à la régression classique, en relation, notamment, avec la colinéarité. Enfin, nous terminerons par quelques conclusions. [less ▲]

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See detailENANTIOSELECTIVE SYNTHESES OF NCA (S)-L-[BETA-C-11]-4-CHLOROPHENYLALANINE AND (S)-L-(ALPHA-METHYL)-[BETA-C-11]-4-CHLOROPHENYLALANINE
Plenevaux, Alain ULg; Al-Darwich, M. J.; Lemaire, Christian ULg et al

in Applied Radiation & Isotopes (1994), 45(3), 361-369

The radiolabeling of (S)-L-4-chlorophenylalanine and (S)-L-(alpha-methyl)-4-chlorophenylalanine were realized with carbon-11 at position beta through a radiochemical synthesis relying on the highly ... [more ▼]

The radiolabeling of (S)-L-4-chlorophenylalanine and (S)-L-(alpha-methyl)-4-chlorophenylalanine were realized with carbon-11 at position beta through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro[alpha-C-11]benzyl bromide and the lithium enolate of (S)-1-(t-butyloxycarbonyl)-2-(t-butyl)-3-methyl-1,3-imidazolidine-4-one for (S)-L-[beta-C-11]-4-chlorophenylalanine and of (2S,5S)-1-(t-butyloxycarbonyl)-2-(t-butyl)-3,5-dimethyl-1,3-imidazolidin e-4-one for (S)-L-(alpha-methyl)-[beta-C-11]-4-chlorophenylalanine. Quantities of about 25-35 mCi were obtained at the end of synthesis, ready for injection, after hydrolysis and HPLC purification with a radiochemical yield of 19% corrected to EOB within 45 min. The enantiomeric excesses were shown to be greater than or equal to 97% for both molecules without chiral separation. The radiochemical and the chemical purities of the final compounds were greater than or equal to 98% and the specific activity at the end of synthesis ranged between 250-800 mCi/mu mol. [less ▲]

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See detailMetabolic clearance rate of insulin in type 2 diabetic patients treated with combined insulin and sulfonylurea therapy.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Revista Espanola de Fisiologia (1994), 50(1), 27-34

The metabolic clearance rate of insulin (MCRI) in 10 non-obese type 2 diabetic patients treated with either insulin alone or combined insulin plus sulfonylurea therapy is investigated. A classical 2-hour ... [more ▼]

The metabolic clearance rate of insulin (MCRI) in 10 non-obese type 2 diabetic patients treated with either insulin alone or combined insulin plus sulfonylurea therapy is investigated. A classical 2-hour euglycaemic hyperinsulinaemic glucose clamp using the artificial pancreas was performed in a randomized order after two 6-week periods of treatment: either with subcutaneous injections of insulin alone or with insulin plus oral administration of the sulfonylurea compound glipizide at the dose of 3 x 10 mg/day. The MCRI was calculated knowing the constant insulin infusion rate (0.1 U.kg-1.h-1) and measuring basal and steady-state plasma free insulin and C-peptide levels. When the test was performed at the end of the period of treatment with insulin plus glipizide and 30 min after the ingestion of the last dose of 10 mg glipizide, plasma C-peptide levels were significantly increased and steady-state free insulin levels tended to be slightly higher whereas the metabolic clearance rate of glucose was not affected. The MCRI was significantly reduced by glipizide from 23.3 +/- 2.9 to 18.9 +/- 2.0 ml.kg-1.min-1 p < 0.05. These results demonstrate that the sulfonylurea glipizide decreases the MCRI. This effect may play a role in the hypoglycemic action of sulfonylureas. [less ▲]

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See detailTechnical Efficiency and Productivity Growth in an Era of Deregulation: the Case of Airlines
Distexhe, Véronique; Perelman, Sergio ULg

in Schweizerische Zeitschrift für Volkswirtschaft und Statistik = Revue Suisse d'Economie Politique et de Statistique (1994), (130), 669-689

In this paper we measure technical efficiency and productivity gains in airline activities. Non-parametric frontiers and Malmquist indices of productivity are estimated for thirty-three airlines observed ... [more ▼]

In this paper we measure technical efficiency and productivity gains in airline activities. Non-parametric frontiers and Malmquist indices of productivity are estimated for thirty-three airlines observed over the period 1977-1988. We identify three sources of growth: technological progress, efficiency change and route network characteristics. The results bring to light the reasons that pushed several airlines to merge when markets were deregulated. [less ▲]

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See detailBovine Leukemia Virus
Kettmann, Richard ULg; Burny, A.; Callebaut, I. et al

in The Retroviridae (1994)

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See detailRôle de la chirurgie carotidienne dans la prévention de l'infarctus cérébral
Limet, Raymond ULg; DESIRON, Quentin ULg; DETRY, Olivier et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1994), 149(5-7), 299-305306-7

A significant part of transient or permanent cerebral ischemic attacks (CIA) are due to arterio-arterial emboli issued from carotid plaques. Surgery for carotid disobstruction aims to take out emboligenic ... [more ▼]

A significant part of transient or permanent cerebral ischemic attacks (CIA) are due to arterio-arterial emboli issued from carotid plaques. Surgery for carotid disobstruction aims to take out emboligenic plaques by endarterectomy (associated to angioplasty or not). The adversaries of surgical treatment sustain two main assertions: 1. carotid stenoses are not very dangerous, because the definitive thromboses they create are easily compensated by the development of collaterals, so that the risk for stroke is low. 2. this low and late risk of spontaneous carotid thrombosis is not greater than the immediate one following carotid surgery. Those objections have been encountered in randomized North American studies (Nascet [less ▲]

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See detailLongwave Sky Radiation Parametrizations
Aubinet, Marc ULg

in Solar Energy (1994), 53(2),

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See detailCONTINUOUS ENZYMATIC-SYNTHESIS OF 2'-DEOXYTHYMIDINE-5'(ALPHA-D-GLUCOPYRANOSYL)DIPHOSPHATE
Zervosen, Astrid ULg; ELLING, Lothar; KULA, Maria-Regina

in Angewandte Chemie (International ed. in English) (1994), 33(5), 571-572

The preparation of primary nucleotide sugars like dTDP-glucose with sucrose synthase, a glycosyl transferase in plants, provides an alternative in enzymatic synthesis to the use of highly specific ... [more ▼]

The preparation of primary nucleotide sugars like dTDP-glucose with sucrose synthase, a glycosyl transferase in plants, provides an alternative in enzymatic synthesis to the use of highly specific pyrophosphorylases. In an enzyme membrane reactor a continuous synthesis can be performed on preparative scale. [less ▲]

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See detailUne contrefaçon liégeoise exemplaire : les Œuvres du philosophe bienfaisant (1764)
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1994), 265

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See detailGeometric control of a pyridoxal-catalyzed aldol condensation
Koh, John T.; Delaude, Lionel ULg; Breslow, Ronald

in Journal of the American Chemical Society (1994), 116(25), 11234-11240

A chiral cyclophane derivative of pyridoxal has been synthesized that has amino groups oriented specifically over one face of the cofactor. The compound catalyzes the formation of threonine and allo ... [more ▼]

A chiral cyclophane derivative of pyridoxal has been synthesized that has amino groups oriented specifically over one face of the cofactor. The compound catalyzes the formation of threonine and allo-threonine from glycine and acetaldehyde with enantioinductions that are a function of pH, reversing the optical selectivity between low pH and high pH. The stereochemical results are compared with those of structurally related pyridoxal cyclophanes that lack titratable catalytic groups. Explanations are advanced for this stereochemical reversal and for the otherwise surprising preference of most of these compounds to react on the more hindered face of the pyridoxal. Models indicate that the transamination intermediate is distorted by the transannular chain, and stereoelectronic arguments predict that this distortion should lead to reaction on the face that carries the chain, as observed. The stereochemical reversal with the attached (dimethylamino)alkyl group, as a function of pH, may reflect catalysis by the protonated form, but metal coordination by the basic form cannot be excluded. [less ▲]

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See detailLes manifestations neurologiques de l'infection a Borrelia burgdorferi (maladie de Lyme).
PEPIN, Jean-Louis ULg; Bastings, Eric; Lenaerts, Marc ULg et al

in Revue Médicale de Liège (1994), 49(11), 603-10

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See detailMuscle Fibre Type and Size, and Muscle Capillary Density in Young Double-Muscled Blue Belgian Cattle
Stavaux, D.; Art, Tatiana ULg; Mc Entee, Kathleen ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1994), 41(3), 229-236

Bovine muscle biopsies were analysed for fiber type and capillary density by the acid ATP-ase and amylase-PAS methods respectively. Samples obtained from Belgian blue double muscled (DM) calves were ... [more ▼]

Bovine muscle biopsies were analysed for fiber type and capillary density by the acid ATP-ase and amylase-PAS methods respectively. Samples obtained from Belgian blue double muscled (DM) calves were compared for their fibre type, size and vascularization with samples from Friesian (F) calves. The animals were sampled both at 2 and 7 months of age. Changes in histochemical composition occurring with ageing, independently of the breed, and differences related to the muscle sampled by comparing biopsies obtained from the longissimus dorsi (LD) and gluteobiceps (GB) muscles in animals of both breed were also investigated. Independently of age and muscle, fibre type I percentage and area were significantly higher in F than in DM muscles. Type IIa area was significantly larger in F than in DM, while fibre type IIb percentage and area were higher in DM. The number of capillaries/mm2 was significantly higher in F than in DM. Fibre type IIa and IIb percentage as well as the diameter of the three fibre types was significantly higher in the oldest animals. Finally, independently of age and breed, fibre type I and IIb percentages were significantly higher in LD but lower in GB. The results mainly demonstrated that Belgian blue DM muscles present a higher proportion of IIb fibres and a lower capillary supply than F muscles. [less ▲]

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See detailMutation analysis of coding sequences for type I procollagen in individuals with low bone density.
Spotila, L. D.; Colige, Alain ULg; Sereda, L. et al

in Journal of Bone and Mineral Research (1994), 9(6), 923-32

Mutations in one of the two genes encoding type I procollagen (COL1A1 and COL1A2) are frequently the cause of osteogenesis imperfecta (OI), a disorder characterized by brittle bones. Here we tested ... [more ▼]

Mutations in one of the two genes encoding type I procollagen (COL1A1 and COL1A2) are frequently the cause of osteogenesis imperfecta (OI), a disorder characterized by brittle bones. Here we tested whether patients with low bone density also have mutations in these genes. The 26 patients studied had no apparent metabolic bone disease, but most had a positive family history of osteopenia or osteoporosis. Although a diagnosis of OI was considered by the clinician in some cases, the clinical criteria for OI were not satisfied. Our strategy for mutation analysis consisted of PCR amplification of cDNA made to fibroblast mRNA using primers specific for the coding regions of COL1A1 and COL1A2. The PCR products were then sequenced directly with primers located within each PCR product. We found that 3 of 26 patients had mutations that altered the encoded amino acid. One mutation, at position alpha 2(I)-661 has been reported (Spotila et al. 1991 Proc Natl Acad Sci USA PNAS 88:5423). The other 2 patients, who were not related to each other, had a mutation that altered the proline codon at alpha 1(I)-27 to alanine. This mutation was not found in 81 normal individuals or in 37 additional osteopenic individuals. However, its effect on the biologic function of type I collagen, as well as its role in osteopenia, is uncertain. In addition to the two mutations, we found a polymorphism in codon alpha 2(I)-459. Although this polymorphism involved an amino acid substitution, it was present with equal frequency in the patient and the normal population. By analyzing this and previously reported neutral sequence variants in the COL1A2 gene, we determined that all patients expressed both alleles of the COL1A2 gene. The 12 patients who were heterozygous for a COL1A1 neutral sequence variant also expressed both alleles. Here we present all PCR primer and sequencing primer information. The results suggest that surveying a larger group of similarly selected individuals may reveal additional mutations in the COL1A1 or COL1A2 genes. [less ▲]

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See detailAnalysis of the penA gene of Pseudomonas cepacia 249.
Joris, Bernard ULg; Galleni, Moreno ULg; Frère, Jean-Marie ULg et al

in Antimicrobial Agents and Chemotherapy (1994), 38(2), 407-8

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See detailEffect of dopamine and baclofen on N-methyl-D-aspartate-induced burst firing in rat ventral tegmental neurons.
Seutin, Vincent ULg; Johnson, S. W.; North, R. A.

in Neuroscience (1994), 58(1), 201-6

Intracellular microelectrode recordings were made from dopamine-containing neurons of the ventral tegmental area or substantia nigra zona compacta in rat brain slices in vitro. The firing pattern of the ... [more ▼]

Intracellular microelectrode recordings were made from dopamine-containing neurons of the ventral tegmental area or substantia nigra zona compacta in rat brain slices in vitro. The firing pattern of the neurons was switched from a tonic, single-spike pattern to a burst firing mode by adding N-methyl-D-aspartate (20 microM) to the superfusing solution; after adding tetrodotoxin the membrane potential underwent rhythmical oscillations of 20-40 mV at 0.5-2 Hz. Baclofen (1 microM) and dopamine (30 microM) hyperpolarized the neurons; when the potential was restored to its original level, the oscillations of potential and/or burst firing were not observed, but the tonic firing pattern was restored. These effects of baclofen and dopamine were prevented by barium (1 mM), which also prevented the membrane hyperpolarization. Oscillations of membrane current of a similar frequency were observed when the somatic membrane was voltage-clamped at -60 mV; these were also blocked by barium (1 mM). It is concluded that the oscillations in membrane potential observed with N-methyl-D-aspartate are generated predominantly at a dendritic location which is not voltage-clamped with an electrode at the soma. Baclofen and dopamine inhibit the oscillations by increasing the potassium conductance and hyperpolarizing the dendrites. [less ▲]

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See detailSerine-Type D-Ala-D-Ala Peptidases and Penicillin-Binding Proteins
Granier, Benoît; Jamin, Marc; Adam, Maggy et al

in Methods in Enzymology (1994), 244

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See detailLa Famille au présent : les valeurs familiales des Belges durant les années 90
Guillaume, Jean-François ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 6(novembre-décembre), 24-29

Analyse de données de l'enquête européenne sur les valeurs (1990). Le texte souligne les valeurs sous-jacentes à un ordre conjugal axé sur la libre disposition de soi et le primat de la relation, au ... [more ▼]

Analyse de données de l'enquête européenne sur les valeurs (1990). Le texte souligne les valeurs sous-jacentes à un ordre conjugal axé sur la libre disposition de soi et le primat de la relation, au risque d'un repli sur soi. Les valeurs éducatives des années 1990 tendent à privilégier l'autonomie, l'ouverture à l'univers extra-familial et à conférer à l'enfant le statut d'un être indépendant. [less ▲]

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See detailApprendre, ou se mettre en projet ? Réflexions au départ d'une expérience de pédagogie du projet en classe du secondaire
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1994), 44e année(n°1), 5-17

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See detailEFFECTS OF ELECTROKINETIC CHARACTERISTICS ON THE FORMATION OF A PROTEIN MICROCRYSTALLINE CELLULOSE COMPLEX
Paquot, Michel ULg; GODIN, F.; Dumont de chassart, Q.

in Lebensmittel-Wissenschaft & -Technologie = Food Science & Technology (1994), 27(1), 11-15

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See detailThe Unbearable Burden of Being: Janet Frame's "Snowman, Snowman"
Delrez, Marc ULg

in Commonwealth : Essays and Studies (1994), 17(1), 89-99

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See detailLiège vue par une géographe
Merenne-Schoumaker, Bernadette ULg

in Cahiers de Clio (1994), (120), 5-16

Présentation générale de Liège

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See detailOxygen Transport Chain in Double-Muscled Blue Belgian Cattle
Lekeux, Pierre ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in British Veterinary Journal (The) (1994), 150(5, Sep-Oct), 463-471

The physiological peculiarities of the oxygen transport chain in double-muscled Blue Belgian cattle are described. The investigations performed at several levels of the oxygen transport chain suggest that ... [more ▼]

The physiological peculiarities of the oxygen transport chain in double-muscled Blue Belgian cattle are described. The investigations performed at several levels of the oxygen transport chain suggest that the increased susceptibility of these cattle to stress, resulting mainly in respiratory diseases, is due to an insufficient functional reserve capacity mainly involving the pulmonary and cardiovascular systems. The resulting lack of 'functional hardiness' of the oxygen transport chain is seen in those double-muscled cattle which do not react in an appropriate or predictable way when submitted to a hostile environment. [less ▲]

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See detailAgglomérations morphologiques et fonctionnelles, l’apport de la télédétection urbaine
Donnay, Jean-Paul ULg

in Acta Geographica Lovaniensia (1994), 34

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See detailCell localization and redistribution of the 67 kD laminin receptor and alpha 6 beta 1 integrin subunits in response to laminin stimulation: an immunogold electron microscopy study.
Romanov, V.; Sobel, M. E.; pinto da Silva, P. et al

in Cell Adhesion and Communication (1994), 2(3), 201-9

The 67 kDa laminin receptor (67LR), one of several cell surface laminin-binding proteins, is involved in the interactions between cancer cells and laminin during tumor invasion and metastasis. A 37 kDa ... [more ▼]

The 67 kDa laminin receptor (67LR), one of several cell surface laminin-binding proteins, is involved in the interactions between cancer cells and laminin during tumor invasion and metastasis. A 37 kDa polypeptide (37LRP), previously identified as the 67LR precursor, is abundantly present in the cytoplasm and has been implicated in polysome formation. To better understand the cellular localization of the 67LR and its precursor, transmission electron microscopic studies of human melanoma A2058 cells were carried out using immunogold labeling and a variety of antibodies: (a) affinity purified antibodies directed against 37LRP cDNA-derived synthetic peptides; (b) anti-67LR monoclonal antibodies raised against intact human small cell lung carcinoma cells; and (c) monoclonal antibodies against the subunits of the integrin laminin receptor, alpha 6 beta 1. Double-labeling immunocyto-chemistry revealed that anti-67LR monoclonal antibodies as well as anti-37 LRP antibodies recognized antigens that were localized in the cytoplasm in electron dense structures. As expected, cell membrane labeling was also observed. Surprisingly, alpha 6 and beta 1 integrin subunits were detected in the same cytoplasmic structures positive for the 67LR and the 37LRP. After addition of soluble laminin to A2058 cells in suspension, the number of labeled cytoplasmic structures increased especially in the vicinity of the plasma membrane, and were exported onto the cell surface. Neither fibronectin nor BSA induced such an effect. The data demonstrate that the 67 LR and the 37 LRP antibodies detect colocalized antigens that are in cytoplasmic structures with alpha 6 beta 1 integrin.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailR. Sacré, « Les Negro Spirituals et les Gospel Songs »
Pirenne, Christophe ULg

in Cahiers de Clio (1994), 119

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See detailEnantioselective synthesis of 6-[fluorine-18]-fluoro-L-dopa from no-carrier-added fluorine-18-fluoride.
Lemaire, Christian ULg; Damhaut, Philippe; Plenevaux, Alain ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1994), 35(12), 1996-2002

METHODS: A trimethylammonium veratraldehyde triflate was synthesized and used as a precursor for the asymmetric synthesis of 6-[18F]fluoro-L-dopa. RESULTS: Its nucleophilic fluorination with 18F-fluoride ... [more ▼]

METHODS: A trimethylammonium veratraldehyde triflate was synthesized and used as a precursor for the asymmetric synthesis of 6-[18F]fluoro-L-dopa. RESULTS: Its nucleophilic fluorination with 18F-fluoride produced by the 18O(p,n)18F nuclear reaction on enriched 18O-water led to the corresponding no-carrier-added [18F]fluoroveratraldehyde (45 +/- 5% EOB). Diiodosilane was used to prepare the corresponding [18F]fluorobenzyl iodide (36.5 +/- 5.3% EOB). Akylation of (S)-1-tert-boc-2-tert-butyl-3-methyl-4-imidazolidinone with this electrophilic agent, hydrolysis and purification by preparative high-pressure liquid chromatography made 6-[18F]fluoro-L-dopa ready for human injection, in a 23% +/- 6% decay-corrected radiochemical yield. The enantiomeric purity and the specific activity were above 96% and 1 Ci/mumole respectively. CONCLUSION: Through this procedure, starting from 250 mCi of 18F-fluoride, multimillicurie amounts (32 +/- 8.5 mCi) of no-carrier-added 6-[18F]fluoro-L-dopa are now available at the end of synthesis (90 min) with a good radiochemical purity (more than 98%). [less ▲]

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See detailComplete Dna-Sequence Of Yeast Chromosome-Xi
Dujon, Bernard; Esteban, Pf.; Fernandes, L. et al

in Nature (1994), 369(6479),

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See detailStimulation of glutatione-peroxidase activity decreases HIV type-1 activation after oxidative stress
Sappey, C.; Legrand, Sylvie ULg; Best-Belopmme, M. et al

in AIDS Research and Human Retroviruses (1994), 10(11), 1451-1461

Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this ... [more ▼]

Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity in latently infected T lymphocytes. The Se-supplemented cells exhibited an important protection against the cytotoxic and reactivating effects of hydrogen peroxide (H2O2). Concomitantly, NF-kappa B activation by H2O2 was also decreased in Se-supplemented cells. Selenium stimulation of GPx activity also induces a protective effect against cell activation by tumor necrosis factor alpha (TNF-alpha) but less significantly by phorbol esters such as PMA. These Se-mediated effects were specific because they were not found when AP-1 DNA-binding activity was studied after H2O2-induced stress. Hyperthermia was also studied because it could promote intracellular electron leakage in electron transport chains. Elevating the temperature to 42 degrees C did not induce NF-kappa B directly. Rather, it sensitized infected cells to subsequent oxidative stress by H2O2, demonstrating the importance of hyperthermia, often associated with opportunistic infections in the development of immunodeficiency. In this case, Se induced partial protection against the sensitizing effect of hyperthermia. [less ▲]

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See detailGenetic diversity among some wild populations of lima bean (Phaseolus lunatus L.) proceeding from Central Valley of Costa Rica
Maquet, Alain; Wathelet, Bernard ULg; Dubois, Sophie et al

in Annual Report of the Bean Improvment Cooperative (1994)

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See detailLe Christ de Wavreumont
Van den Bossche, Benoît ULg

in Folklore. Stavelot – Malmedy – Saint-Vith (1994), 55

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See detailEffect of recombinant human erythropoietin on platelets in patients with anemia of renal failure: correlation of platelet count with erythropoietic activity and iron parameters.
Beguin, Yves ULg; Loo, Martine; R'Zik, Samir ULg et al

in European Journal of Haematology (1994), 53(5), 265-70

We examined the effect of treatment with rHuEpo on platelet counts in 61 hemodialysis patients and correlated them with changes in erythropoietic activity, iron status and inflammation. Platelets (10(9)/1 ... [more ▼]

We examined the effect of treatment with rHuEpo on platelet counts in 61 hemodialysis patients and correlated them with changes in erythropoietic activity, iron status and inflammation. Platelets (10(9)/1) increased from 220 +/- 80 to 245 +/- 102 after 14 days and stabilized at that level up to day 90 (p < 0.0001). The increment was similar in complete or partial responders but was not observed in failures. Serum transferrin receptor (sTfR, a measure of total erythropoiesis) and Het rose much more progressively, but relative platelet increments correlated with relative increases in sTfR and Hct. Relative platelet increments correlated inversely with relative changes of SeFe or transferrin saturation, but not with their absolute values, nor with baseline ferritin or its progressive decrease. Although baseline platelet count was 12% higher in patients with inflammation and correlated with serum haptoglobin, relative increases were similar in patients with or without inflammation. In conclusion, rHuEpo produced a clinically minor but consistent elevation of platelet counts. These modifications were not related primarily to modifications in iron stores, functional iron deficiency, or inflammation, but paralleled the expansion of erythropoietic activity. The results suggest that rHuEpo has a small positive effect on platelet production, but it cannot be ruled out that this could be partially mediated through functional iron deficiency. [less ▲]

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See detailLa crise suicidaire de l'adolescent, un appel à la vie
Malchair, Alain ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 2

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