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See detailWiktor stent for treatment of chronic total coronary artery occlusions: short- and long-term clinical and angiographic results from a large multicenter experience.
Anzuini, A.; Rosanio, S.; Legrand, Victor ULg et al

in Journal of the American College of Cardiology (1998), 31(2), 281-8

OBJECTIVES: This study reports the first multicenter experience with the Wiktor coil stent for treatment of chronic total coronary artery occlusions (CTOs). BACKGROUND: Percutaneous transluminal coronary ... [more ▼]

OBJECTIVES: This study reports the first multicenter experience with the Wiktor coil stent for treatment of chronic total coronary artery occlusions (CTOs). BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) of CTO is associated with very high restenosis and reocclusion rates. Coronary stenting has been proposed as a means of improving outcome. However, the Wiktor device for CTOs has never been tested in a large patient sample. METHODS: From January 1993 to December 1996, 89 patients with 91 CTOs underwent Wiktor stent implantation after successful PTCA. The post-stenting regimen consisted of warfarin (Coumadin) plus aspirin in the initial 49 patients (55%) and aspirin plus ticlopidine in 40 patients (45%). RESULTS: Stenting was successful in 87 patients (98%). At 1 month, 6% of patients had subacute stent thrombosis, 3% had a major bleeding event, and 1% had access-site complications. Subacute stent thrombosis showed univariate association with warfarin therapy (p = 0.009). Angiographic follow-up was obtained in 76 (93%) of 82 eligible patients. The restenosis rate was 32%, including 4% reocclusions. By multiple logistic regression analysis, restenosis was independently associated with multiple stents (adjusted odds ratio [OR] 27.67, 95% confidence interval [CI] 4.25 to 79.95, p = 0.0008) and increasing values of occlusion length (adjusted OR 1.23, 95% CI 1.09 to 1.39, p = 0.001). Freedom from death, myocardial infarction or stented vessel revascularization was 87% and 72% at 1 and 3 years, respectively. CONCLUSIONS: Short- and long-term clinical and angiographic outcomes are favorable in patients undergoing Wiktor stent implantation in CTO. Further technical improvement is needed to reduce the restenosis rate in patients with long lesions and multiple stents. [less ▲]

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See detailComparative Evaluation of Cerebral Aneurysms with Selective Arterially Enhanced Ct and Dsa
Vanderschelden, P.; Flandroy, P.; Dondelinger, R. F. et al

in European Radiology (1998), 8(7), 1181-6

The purpose of our study was to compare selective arterially enhanced spiral computed tomographs (ACT) with digital subtraction angiographies (DSA) in the presurgical assessment of cerebral aneurysms. A ... [more ▼]

The purpose of our study was to compare selective arterially enhanced spiral computed tomographs (ACT) with digital subtraction angiographies (DSA) in the presurgical assessment of cerebral aneurysms. A total of 24 aneurysms in 18 patients were explored in a prospective study by ACT and DSA, using an interactive combined CT-angiography suite. Dimensions of the aneurysm, its relation to the parent vessel, and the aneurysmal index were defined on DSA and on surface-shaded display of 3D reformatted images obtained from ACT. Results were correlated with surgical findings. Three aneurysms suspected on DSA were not confirmed by ACT. One fusiform aneurysm suspected on DSA corresponded to a sacciform aneurysm on ACT. Surgical findings confirmed 20 sacciform aneurysms. The aneurysmal index could be measured in all 20 cases of sacciform aneurysms on ACT and could not be determined with confidence in 55 % of the cases on DSA. DSA and ACT gave identical results in 35 % of cases. In 10 %, the index measured by ACT was superior to that determined by DSA for aneurysms which had a diameter of less than 3 mm. In conclusion, the combination of DSA and ACT improved the results of DSA alone. ACT is a reliable method to measure the aneurysmal index in aneurysms with a diameter superior to 3 mm. [less ▲]

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See detailDeux nouvelles espèces de Byssoloma Trev. (lichens Pilocarpaceae) d'Europe Occidentale et de Macaronésie
Sérusiaux, Emmanuël ULg

in Cryptogamie. Bryologie, Lichenologie (1998), 19

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See detailDifferential growth dependency of normal and habituated sugarbeet cell lines upon endogenous ethylene production and exogenous ethylene application
Bisbis, Badia; Kevers, Claire ULg; Creche, Joel et al

in Physiologia Plantarum (1998), 103(2), 201-208

A fully habituated (auxin- and cytokinin-independent) nonorganogenic (HNO) sugarbeet (Beta vulgaris) callus produces very little ethylene as compared with a normal (N) hormone-requiring callus of the same ... [more ▼]

A fully habituated (auxin- and cytokinin-independent) nonorganogenic (HNO) sugarbeet (Beta vulgaris) callus produces very little ethylene as compared with a normal (N) hormone-requiring callus of the same strain. Both callus types react by growth changes to application of inhibitors of ethylene biosynthesis and ethylene action, of 1-aminocyclopropane-1-carboxylic acid (ACC) as the immediate precursor of ethylene, to transfer from light to darkness, and also to application of exogenous ethylene or an ethylene trapper. This indicates their growth dependency upon their endogenously biosynthesized ethylene and also their sensitivity to exogenous gas. However, the sensitivity was generally higher for the HNO callus producing naturally less ethylene. The weaker reaction of the HNO callus to the exogenous ethylene was attributed to its hyperhydric status (a water layer surrounding the cells). Because low ethylene production appears as a general characteristic of habituated cell lines, the causal and/or consequential relationships of this low ethylene production with other characteristics of habituated tissues (absence of exogenous hormones in the culture media, deficiency of cell differentiation, accumulation of polyamines in neoplastic tissues) are discussed. [less ▲]

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See detailA further new species of Monoblastia (lichenized ascomycetes: Monoblastiaceae) from Papua New Guinea
Sérusiaux, Emmanuël ULg; Aptroot, André

in Nova Hedwigia (1998), 67

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See detailLa communication dans la démocratie du 3e millénaire
Vromans, Joseph ULg

in Actes de la XXième Session de l'Institut d'Etudes Mondialistes (1998)

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See detailLes fossiles végétaux du Dévonien inférieur de Fooz-Wépion (bord nord du Synclinorium de Dinant, Belgique). IV. Deuterophyton stockmansii gen. et nov. sp.
Gerrienne, Philippe ULg

in Comptes Rendus de l'Académie des Sciences. Série II. Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (1998), 326

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See detailComparison of the Internal Energy Distributions of Ions Produced by Different Electrospray Sources
Collette, Caroline ULg; Drahos, Laszlo; De Pauw, Edwin ULg et al

in Rapid Communications in Mass Spectrometry : RCM (1998), 12

The internal energies of the emitted ions can be modulated in an electrospray source through different experimental conditions. However, the fragmentation pattern depends also on conditions that cannot be ... [more ▼]

The internal energies of the emitted ions can be modulated in an electrospray source through different experimental conditions. However, the fragmentation pattern depends also on conditions that cannot be controlled by the operator. These differences make difficult the comparison of the electrospray mass spectra obtained with different mass spectrometers. A method for the calibration of the internal energies of ions produced by an electrospray source has been presented previously to study the influence of experimental conditions on the internal energies of the ions. In this work, new results were obtained with modified values of fragmentation energy taking into account the kinetic shift of thermometer ions. [less ▲]

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See detailLifetime measurements in odd-parity Rydberg series of neutral Lead by time-resolved laser spectroscopy
Li, Z. S.; Svanberg, S.; Biémont, Emile ULg et al

in Physical Review. A (1998), 57

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See detailL'hyperventilation chronique existe-t-elle?
Delvaux, Muriel ULg; Fontaine, Philippe; Fontaine, Ovide ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (1998), 3(3), 1-9

Longtemps, on a considéré que les sujets atteints d’attaques de panique étaient des hyperventilants chroniques qui plongeaient soudainement en hypocapnie. En fait, l’examen des résultats au test de ... [more ▼]

Longtemps, on a considéré que les sujets atteints d’attaques de panique étaient des hyperventilants chroniques qui plongeaient soudainement en hypocapnie. En fait, l’examen des résultats au test de provocation d’hyperventilation, de la rééducation respiratoire et de la mesure ambulatoire de PCO2 montre qu’il n’y a pas de recouvrement parfait entre les deux phénomènes. Le syndrome d’hyperventilation est sans doute une entité à part entière. Les modèles biologiques se basent sur les expériences utilisant le lactate ou le dioxyde de carbone pour aboutir, avec Klein (1993), à l’hypothèse d’une hypersensibilité au CO2. Les modèles psychologiques envisagent diverses options. Lum (1994) y voit la conséquence d’une mauvaise habitude respiratoire. Pour Clark (1986), l’hyperventilation joue un rôle dans les attaques de panique seulement si elle est interprétée de manière catastrophique. Ley (1993) considère la dyspnée comme l’élément initiateur d’un réflexe de peur innée. Enfin, Van den Bergh (1995) a réalisé des études prometteuses sur le conditionnement respiratoire. Si tous les sujets souffrant d’attaques de panique ne sont pas des hyperventilants chroniques, il faut admettre que les deux phénomènes coexistent souvent. Une approche intégrative des modèles biologiques et psychologiques pourrait éclaircir la nature de leur relation. [less ▲]

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See detailContrôle de la qualité des pommes par vision artificielle.
Leemans, Vincent ULg; Magein, Hugo ULg; Destain, Marie-France ULg

in Fruit Belge (1998), 66(471),

Article de vulgarisation à destination des profesionnels du secteur fruitier, présentant les possibilités de l'analyse d'images numériques pour le tri des fruits suivant leur qualité externe

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See detailDe quelques questions posées à l'occasion d'une demande de facilités de paiement, obs. sous J.P. Soignies, 29 mai 1997
Biquet, Christine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

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See detailA Descriptive Analysis Of Populations Of Three-Dimensional Structures Calculated From Primary Sequences Of Proteins By Osiris
Benhabiles, N.; Gallet, X.; Thomas, Annick ULg et al

in Journal of Computational Biology (1998), 5(2), 351-66

Among different ab initio approaches to calculate 3D-structures of proteins out of primary sequences, a few are using restricted dihedral spaces and empirical equations of energy as is OSIRIS. All those ... [more ▼]

Among different ab initio approaches to calculate 3D-structures of proteins out of primary sequences, a few are using restricted dihedral spaces and empirical equations of energy as is OSIRIS. All those approaches were calibrated on a few proteins or fragments of proteins. To optimize the calculation over a larger diversity of structures, we need first to define for each sequence what are good conditions of calculations in order to choose a consensus procedure fitting most 3D-structures best. This requires objective classification of calculated 3D-structures. In this work, populations of avian and bovine pancreatic polypeptides (APP, BPP) and of calcium-binding protein (CaBP) are obtained by varying the rate of the angular dynamics of the second step of OSIRIS. Then, 3D-structures are clustered using a nonhierarchical method, SICLA, using rmsd as a distance parameter. A good clustering was obtained for four subpopulations of APP, BPP and CaBP. Each subpopulation was characterized by its barycenter, relative frequency and dispersion. For the three alpha-helix proteins, after the step 1 of OSIRIS, most secondary structures were correct but molecules have a few atomic contacts. Step 2, i.e., the angular dynamics, resolves those atomic contacts and clustering demonstrates that it generates subpopulations of topological conformers as the barycenter topologies show. [less ▲]

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See detailInterictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices.
Afra, Judit; Mascia, Adolores; GERARD, Pascale ULg et al

in Annals of Neurology (1998), 44(2), 209-15

We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks ... [more ▼]

We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks. By using a 13-cm circular coil placed over the vertex and recordings of the first dorsal interosseus muscle, we measured thresholds (at rest and during contraction), amplitudes of motor evoked potentials and cortical silent periods. Paired stimulations with short (1-20 msec) interstimulus intervals were performed to assess intracortical inhibition. The visual cortex was stimulated with the same coil placed over the occipital scalp (7 cm above the inion) and the prevalence and threshold of phosphene production was determined. In patients with migraine with aura, motor thresholds during isometric contraction were significantly higher, whereas the prevalence of stimulation-induced phosphene production was lower compared with healthy controls. These changes were not correlated with attack frequency or disease duration. No differences were found between subject groups in thresholds at rest, motor evoked potential amplitudes, cortical silent periods, or response curves after paired stimuli. These results are in favor of cortical hypoexcitability rather than hyperexcitability in patients with migraine with aura between attacks. [less ▲]

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See detailCas d'un ulcère à Exophiala dermatitidis
Gérard, C.; Duchesne, Bernard ULg; Hayette, Marie-Pierre ULg et al

in Bulletin de la Société Belge d'Ophtalmologie (1998), 268

Les auteurs présentent un cas d'ulcère cornéen à Exophiala dermatitidis. Ce cas permet d'envisager la classification des mycoses cornéennes ainsi que leur fréquences. L'histoire clinique et l'aspect ... [more ▼]

Les auteurs présentent un cas d'ulcère cornéen à Exophiala dermatitidis. Ce cas permet d'envisager la classification des mycoses cornéennes ainsi que leur fréquences. L'histoire clinique et l'aspect biomicroscopique permettent de mettre en évidence les critères diagnostiques des infections mycotiques. L'intérêt et la techique des prélèvements seront discutés. l'analyse anatomopathologique après greffe de cornée confirme le diagnostic et nous rappelle la place essentielle de cet examen trop souvent négligé. L'attitude thérapeutique tant médicale que chirurgicale sera discutée. [less ▲]

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See detailCalibration of the Internal Energy Distribution of Ions Produced by Electrospray
Collette, Caroline ULg; De Pauw, Edwin ULg

in Rapid Communications in Mass Spectrometry : RCM (1998), 12

The internal energy deposited in the ions in the source of mass spectrometer governs their fragmentation and therefore the content of the spectra. When the ionization conditions are well defined and ... [more ▼]

The internal energy deposited in the ions in the source of mass spectrometer governs their fragmentation and therefore the content of the spectra. When the ionization conditions are well defined and reproductible, the elaboration of databases benefits the use of the method. In electrospray, however, the source conditions are not strictly defined. The elaboration of spectra databases therefore requires a calibration of internal energy of the ions. In this article, a method for the calibration of the internal energy of the ions in electrospray is presented, developed using fragmentation reactions of a set of probe ions (benzylpyridinium salts) under various conditions. [less ▲]

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See detailStudy of vaccinia virus binding and entry using confocal microscopy, an original approach
Vanderplasschen, Alain ULg; Smith, G. L.

in Biology of the Cell (1998), 90

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See detailLe vétérinaire et les médicaments : cadre légal actuel
Gustin, Pascal ULg; Laurier, L.; Plume, C.

in Annales de Médecine Vétérinaire (1998), 142

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See detailConsistent view of electrolytes in aqueous two-phase systems
Pfennig, Andreas ULg; Schwerin, Albrecht; Gaube, Johann

in Journal of Chromatography. B : Biomedical Sciences and Applications (1998), 711((1-2)), 45-52

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See detail1-anilino-8-naphtalene sulfonate probes a gastric HK-ATPase potassium site whose access requires ionophores.
Festy, F.; Lins, Laurence ULg; Gallet, X. et al

in Journal of Membrane Biology (1998), 165(2), 153-60

1-anilino-8-naphtalenesulfonate (ANS) is a hydrophobic dipole previously used to demonstrate that the proton for potassium exchange by the gastric HK-ATPase is electroneutral. In this paper, we ... [more ▼]

1-anilino-8-naphtalenesulfonate (ANS) is a hydrophobic dipole previously used to demonstrate that the proton for potassium exchange by the gastric HK-ATPase is electroneutral. In this paper, we demonstrate that ANS binds to gastric membranes and probes conformational changes of the HK-ATPase independently of any active H for K exchange. Conformational changes require the presence of potassium-valinomycin and are not triggered by sodium. Potassium effect is enhanced by ATP, in the presence and in the absence of magnesium and, by ADP, in the presence of magnesium. Labeling of the pig HK-ATPase K518 by fluorescein-5-isothiocyanate inhibits the enzyme activity and knocks out the ATP effect on ANS fluorescence. Scherring 28080 and the monoclonal antibody 95-111, two competitive inhibitors of K-activated ATPase dephosphorylation, do not modify K-effect on ANS fluorescence but inhibit ATP effects. This supports that ANS does not probe K-site between the H1-H2 loop. Treatment of gastric membranes with trypsin does not inhibit the ANS response to potassium but does inhibit the response to ATP. This suggests that the ATP site inducing the ANS response is cytoplasmic and the potassium site is intramembranous. Titration reveals that one mole of ANS interacts with one mole of ATPase. We suggest that ANS probes a hydrophobic potassium site of gastric ATPase and that addition of ATP and ADP-Mg embed that site. [less ▲]

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See detailAdverse effect of hyperinsulinemia on cardiovascular risk profile in middle-aged belgian population
Saint-Remy, Annie ULg; Scheen, André ULg; Jeanjean, Michel et al

in Acta Cardiologica (1998), 53(5), 299

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See detailTourisme et plans d'aménagement
Delnoy, Michel ULg

in Aménagement - Environnement (1998), n° spécial

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See detailLifetimes and oscillator strengths for ultravilolet transitions in neutral sulfur
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Federman, S. R. et al

in Astrophysical Journal (1998), 502

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See detailConditioned sensitization to the behavioural effects of amphetamine and habituation to the testing context
Tirelli, Ezio ULg; Terry, P.

in Behavioural Pharmacology (1998), 10

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See detailStudy of siliceous karst genesis in eastern Niger : microscopy and X ray microanalysis of speleothems
Willems, Luc; Compère, Philippe ULg; Sponholz, Barbara

in Zeitschrift für Geomorphologie (1998), 42

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See detailNouvelles données lithostratigraphiques sur le Frasnien de l'Anticlinorium de Philippeville
Dumoulin, V.; Marion, Jean-Marc ULg; Boulvain, Frédéric ULg et al

in Annales de la Société Géologique du Nord (1998), II 6

The revision of the Sautour-Surice geological map revealed some important lateral facies variations in the Frasnian of the Philippeville Massif. Two kinds of lithological successions have been observed ... [more ▼]

The revision of the Sautour-Surice geological map revealed some important lateral facies variations in the Frasnian of the Philippeville Massif. Two kinds of lithological successions have been observed, corresponding to the formations newly defined in the Philippeville Massif (proximal facies) and at the southern border of the Dinant Synclinorium (distal facies). The geographic repartition of the two facies is schematically presented. A new section (distal facies) is described from the Hermeton valley (SE of the Philippeville Massif). As a conclusion, the origin of the coexistence of the two facies types in the Philippeville Massif is discussed. [less ▲]

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See detailPhosphorylation of Proteins Induced in a Murine Pre-T Cell Line by Neurohypophysial Peptides
Martens, Henri ULg; Kecha, O.; Charlet-Renard, C. et al

in Advances in Experimental Medicine and Biology (1998), 449

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See detailA pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family.
Charlier, Carole ULg; Singh, N. A.; Ryan, S. G. et al

in Nature Genetics (1998), 18(1), 53-5

Epileptic disorders affect about 20-40 million people worldwide, and 40% of these are idiopathic generalized epilepsies (IGEs; ref. 1). Most of the IGEs that are inherited are complex, multigenic diseases ... [more ▼]

Epileptic disorders affect about 20-40 million people worldwide, and 40% of these are idiopathic generalized epilepsies (IGEs; ref. 1). Most of the IGEs that are inherited are complex, multigenic diseases. To address basic mechanisms for epilepsies, we have focused on one well-defined class of IGEs with an autosomal-dominant mode of inheritance: the benign familial neonatal convulsions (BFNC; refs 2,3). Genetic heterogeneity of BFNC has been observed. Two loci, EBN1 and EBN2, have been mapped by linkage analysis to chromosome 20q13 (refs 5,6) and chromosome 8q24 (refs 7,8), respectively. By positional cloning, we recently identified the gene for EBN1 as KCNQ2 (ref. 9). This gene, a voltage-gated potassium channel, based on homology, is a member of the KQT-like family. Here we describe an additional member, KCNQ3. We mapped this new gene to chromosome 8, between markers D8S256 and D8S284 on a radiation hybrid map. We screened KCNQ3 for mutations in the large BFNC family previously linked to chromosome 8q24 in the same marker interval. We found a missense mutation in the critical pore region in perfect co-segregation with the BFNC phenotype. The same conserved amino acid is also mutated in KVLQT1 (KCNQ1) in an LQT patient. KCNQ2, KCNQ3 and undiscovered genes of the same family of K+ channels are strong candidates for other IGEs. [less ▲]

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See detailIntérêt de l'évaluation fonctionnelle du patient lombalgique fréquentant une école du dos
Vanderthommen, Marc ULg; Drosson, C.; TOMASELLA, Marco ULg et al

in Kiné Acta-Symposium (1998)

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See detailEnseignants de français et d'histoire. Mieux se connaître pour mieux collaborer
Jadoulle, Jean-Louis ULg

in Français 2000 (1998), n°161-162

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See detailLa place du diagnostic dans l'approche familiale
Garcet, Serge ULg

in Revue des Psychologues et Psychiatres de l'AIGS (1998), 1

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See detailLe Projet Catsius Clay
Charlier, Robert ULg; Collin, Frédéric ULg

in Bulletin du Groupement Belge de Mécanique des Roches (1998)

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See detailImmeubles de très grande hauteur: un défi pour l'ingénieur
Franssen, Jean-Marc ULg

in Infrastructuur in het Leefmilieu (1998), 2

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See detailCompte rendu de Le geste et les gestes au Moyen Age. Aix-en-Provence, 1998
George, Philippe ULg

in Moyen Age (Le) (1998)

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See detailIncidence of Inflammatory Bowel Disease in the Area of Liege: A 3 Years Prospective Study (1993-1996)
Latour, Pascale ULg; Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1998), 61(4, Oct-Dec), 410-3

A first prospective epidemiological study of IBD was conducted in the area of Liege. The duration of the study was short taking into account the small size of the population (1 million inhabitants ... [more ▼]

A first prospective epidemiological study of IBD was conducted in the area of Liege. The duration of the study was short taking into account the small size of the population (1 million inhabitants). Therefore we carried out a 3 years prospective study. METHOD: Private and public gastroenterologists completed a questionnaire for each new case they diagnosed between 01.06.1993 and 31.05.1996. RESULTS: During that period 270 IBD patients were identified: 137 (51%) had Crohn's disease (CD), 111 (41%) had ulcerative colitis (UC) including 32 proctitis (29% of UC) and 22 (8%) had unclassified colitis. The mean annual incidence per 10(5) was 4.5 for CD and 3.6 for UC. The female/male ratio was 1,6 for CD and 0,5 for UC. The median age at the time of diagnosis was 30 years for CD and 39 years for UC. The mean time between the onset of symptoms and the diagnosis was 6,5 months for CD and only 4,8 months for UC. Family history of IBD was found in 15% of patients with CD and in 7% of UC. CONCLUSIONS: These data show a high incidence of IBD in the area of Liege. These results confirm those reported during the first year of the prospective study which were similar to those observed in North-western France. Contrary to the other countries of Northern Europe, the incidence of UC is lower than the one of CD. Belgium appears to be a privileged country to undertake a national register and to study epidemiological aspects of IBD. [less ▲]

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See detailIsolation Of Highly Performant Sulfate Reducers From Sulfate-Rich Environments
Hiligsmann, Serge ULg; Jacques, Philippe ULg; Thonart, Philippe ULg

in Biodegradation (1998), 9(3-4), 285-292

Eleven pure strains of sulfate-reducing bacteria have been isolated from lab-scale bioreactors or disposal sites, all featuring relatively high concentrations of sulfate, and from natural environments in ... [more ▼]

Eleven pure strains of sulfate-reducing bacteria have been isolated from lab-scale bioreactors or disposal sites, all featuring relatively high concentrations of sulfate, and from natural environments in order to produce sulfide from gypsum using hydrogen as energy source. The properties of the eleven strains have been investigated and compared to these of three collection strains i.e. Desulfovibrio desulfuricans and vulgaris and Desulfotomaculum orientis. Particular attention was paid to the absolute and relative sulfide production rate and to the hydrogen sulfide inhibition level. By comparison to the collection strains, a 75 % higher production rate and a hydrogen sulfide inhibition level about twice higher i.e. 25.1 mM have been achieved with strains isolated from sulfate-rich environments. The strain selection, particularly from sulfate-rich environments, should be considered as an optimization factor for the sulfate reduction processes. [less ▲]

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See detailApplication of CAPE techniques to the revamping of existing electrical power plants: an example of interdisciplinary collaboration.
Heyen, Georges ULg; Vrielynck, B.; Kalitventzeff, Boris ULg

in Computers & Chemical Engineering (1998), 22(Suppl. S), 239-246

Coupling of a partial oxidation reactor with a gas turbine. is proposed to increase the capacity and efficiency of thermal power plants. The exhaust of the partial oxidation gas turbine:is a preheated ... [more ▼]

Coupling of a partial oxidation reactor with a gas turbine. is proposed to increase the capacity and efficiency of thermal power plants. The exhaust of the partial oxidation gas turbine:is a preheated fuel that can be burned with little modification in the existing steam generator. The feasibility study requires the development of a reliable model for an existing 250 MW power plant. Data reconciliation is found valuable for obtaining precise mass and energy balances and for screening out unreliable measurements. The identification of model parameters from reconciled values is then straightforward. The same validation Software is later applied to rating simulation of the modified plant, by merging the partial oxidation gas turbine in the model. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailComment j'explore ... un sujet avec une concentration basse de cholesterol HDL.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(11), 711-4

A decrease in plasma HDL cholesterol concentration is considered as a major cardiovascular risk factor and is a prevalent lipid abnormality among patients with coronary heart disease. This condition is ... [more ▼]

A decrease in plasma HDL cholesterol concentration is considered as a major cardiovascular risk factor and is a prevalent lipid abnormality among patients with coronary heart disease. This condition is most often observed in the presence of hypertriglyceridaemia, generally linked to the insulin resistance syndrome, but may also be associated to elevated LDL cholesterol level or even be present alone (hypoalphalipoproteinaemia). The decision to treat a patient with low HDL level depends on the individual overall cardiovascular risk which should be evaluated as carefully as possible. The investigation should look for causes which may favour this metabolic condition, such as bad life habits or possible pharmacological interferences. [less ▲]

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See detailEnhanced expression in seminoma of human zinc finger genes located on chromosome 19
Ogawa, Takehiko; Poncelet, Dominique A; Kinoshita, Yuzo et al

in Cancer Genetics & Cytogenetics (1998), 100(1), 36-42

Six Kruppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Kruppel-associated box) ZF gene family and also the same ... [more ▼]

Six Kruppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Kruppel-associated box) ZF gene family and also the same chromosomal assignment. Interestingly, Northern blot analyses using ZFS-1 and ZNF91 revealed that multiple ZF genes on chromosome 19 were predominantly expressed in seminomas. In addition, the testis and the seminoma showed specific expression of 2.3 kb transcript. Our results suggest that ZF genes on chromosome 19 may be implicated in the development and/or growth of seminomas. [less ▲]

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See detailDe paardenstalfetisjist
Meesters, Gert ULg

in Over Taal (1998), 37(1), 16-18

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See detailMotivations et satisfactions des dirigeants de clubs sportifs. Cas du football belge francophone à trois niveaux de jeux différents
Cloes, Marc ULg; Ledent, Maryse; Chapelle, Jean-Yves et al

in AES Magazine (1998), 53

Le sport représente un phénomène culturel et social incontournable à l'échelle de la planète. La Commission de la culture, de la jeunesse, de l'éducation et des médias de l'Union européenne considère qu ... [more ▼]

Le sport représente un phénomène culturel et social incontournable à l'échelle de la planète. La Commission de la culture, de la jeunesse, de l'éducation et des médias de l'Union européenne considère qu'il est pratiqué par plus de 100 millions de citoyens européens. Elle a rappelé que ces activités sont liées à des dizaines de milliers de cercles. Traditionnellement, leur fonctionnement repose sur le dévouement de nombreux bénévoles. ... [less ▲]

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See detailOn the appropriateness of marginal models for repeated measurements in clinical trials
Lindsey, James ULg; Lambert, Philippe ULg

in Statistics in Medicine (1998), 17

Although models developed directly to describe marginal distributions have become widespread in the analysis of repeated measurements, some of their disadvantages are not well enough known. These include ... [more ▼]

Although models developed directly to describe marginal distributions have become widespread in the analysis of repeated measurements, some of their disadvantages are not well enough known. These include producing profile curves that correspond to no possible individual, possibly showing that a treatment is superior on average when it is poorer for each individual subject, implicitly generating complex and implausible physiological explanations, including underdispersion in subgroups, and sometimes corresponding to no possible probabilistic data generating mechanism. We conclude that such marginal models may sometimes be appropriate for descriptive observational studies, such as sample surveys in epidemiology, but should only be used with great care in causal experimental settings, such as clinical trials. [less ▲]

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See detailP53, Bax and Bcl-2 in Vivo Expression in the Murine Thymus after Apoptogenic Treatments
Denis, Ghislaine; Humblet, Chantal ULg; Verlaet, Myriam ULg et al

in Anticancer Research (1998), 18(5, Sep-Oct), 3315-21

BACKGROUND: Neoplasia can results from a lack of cell elimination by apoptosis. In order to determine if mechanisms controlling apoptosis are disturbed during neoplastic transformation in a model of ... [more ▼]

BACKGROUND: Neoplasia can results from a lack of cell elimination by apoptosis. In order to determine if mechanisms controlling apoptosis are disturbed during neoplastic transformation in a model of murine radio-induced thymic lymphomas, we have assessed the kinetics of p53, Bax and Bcl-2 in situ expression after induction of thymic apoptosis by irradiation or glucocorticoids at first in normal mice. MATERIALS AND METHODS: TUNEL method was used for in situ detection of apoptosis and protein expression was determined by indirect immunohistochemistry. RESULTS: After hydrocortisone injection, levels of p53 and Bax, but not Bcl-2, expression were raised. A whole body sublethal irradiation led to an increase of p53 and Bcl-2, but not Bax, expression. CONCLUSIONS: This is the first in vivo report of in situ protein expression in the thymus after apoptogenic treatments of mice. The results suggest that Bax could be involved in glucocorticoid-mediated apoptosis. The increased levels of Bcl-2 expression are discussed. [less ▲]

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See detailCompte-rendu - Le nouveau Code wallon de l'aménagement du territoire
Delnoy, Michel ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

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See detailReproducibility and diagnostic sensitivity of ultrasonometry of the phalanges to assess osteoporosis.
Reginster, Jean-Yves ULg; Dethor, M; Pirenne, H et al

in International Journal of Gynecology & Obstetrics (1998), 63(1), 21-8

OBJECTIVE: The present study was designed to assess the reproducibility and the diagnostic sensitivity of the amplitude-dependent speed of sound (SoS) at the distal metaphysis of the proximal phalanges ... [more ▼]

OBJECTIVE: The present study was designed to assess the reproducibility and the diagnostic sensitivity of the amplitude-dependent speed of sound (SoS) at the distal metaphysis of the proximal phalanges. METHOD: Fourteen presumably healthy volunteers were repeatedly measured every 6 weeks for approximately 6 months in order to assess the reproducibility of the SoS of the phalanges. We recruited 91 post-menopausal women, aged 55-75 years, who were divided in three groups according to their lumbar bone mineral density (BMD) and the existence of prevalent vertebral fractures. The objective was to evaluate the diagnostic sensitivity of SoS measurements. We used DBM Sonic 1200 equipment, and assessed the velocity at which US cross the phalanx in a lateral-medial direction. In post-menopausal women, BMD was measured by dual energy X-ray absorptiometry (DXA) at the level of the lumbar spine, the total zone of the non-dominant hip and the femoral neck zone of the non-dominant hip. RESULTS: The precision of the SoS measurements was 0.71+/-0.05% (mean+/-S.E.M) whereas the reproducibility was 0.95+/-0.06%. Subjects with low BMD or prevalent fractures had significantly lower values of SoS (P < 0.001) than the controls. ROC curve analysis applied to the study population confirmed that SoS was able to discriminate between the controls and osteoporotic subjects (area under the ROC curves were 0.82 (low bone mineral density) and 0.85 (prevalent fractures), respectively). Hip BMD was found to be the most significant variable when comparing the controls and the low density patients by stepwise discrimination and SoS significantly improved the discrimination between the groups when added to the hip BMD. The hip BMD was again the most discriminant variable when applying the same techniques to controls and patients with prevalent fractures, followed by SoS and lumbar BMD. A cut-off value of 1881 m/s is defined for SoS by logistic discrimination and likelihood ratio function. With this value, the sensitivity and the specificity for SoS used in the diagnosis of established osteoporosis were, 81.5% and 79.3%, respectively. Sensitivity and specificity were significantly improved when combining ultrasonometry and densitometry. CONCLUSION: Measurement of ultrasound velocity at the phalanges appears to be a precise and reproducible technique. SoS discriminates between normal post-menopausal women and patients with either low lumbar BMD or prevalent fractures to the same extent as BMD measurements. [less ▲]

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See detailClinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure.
Eisele, Bernd; Lamy, Maurice ULg

in Seminars in Thrombosis & Hemostasis (1998), 24(1), 71-80

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years ... [more ▼]

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years and still comes to 35% to 45%. For quite a long time our understanding of the pathophysiology of sepsis was mainly focused on endotoxin and proinflammatory cytokines like tumor necrosis factor or interleukin-1. Now it is generally accepted that many signs and symptoms of sepsis are not directly mediated by cytokines but are transmitted through other mediator systems. The coagulation system comes into play especially when the septic process progresses to malperfusion and organ failure. Antithrombin III is an important inhibitor of the intrinsic, extrinsic and common pathway of coagulation. Recently, evidence has been accumulating that there is an additional anti-inflammatory potential of the drug. Currently there are several clinical trials ongoing to investigate whether this effect is of clinical relevance in the treatment of patients with severe sepsis. [less ▲]

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See detailnote sous J.P. Etalle, 3 février 1997
Moreau, Pierre ULg

in Revue de Droit Judiciaire et de la Preuve = Tijdschrift voor Procesrecht en Bewijsrecht (1998), (5), 312-313

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See detailUse of the yeast YOL112w gene as an experimental tool to elucidate the cellular function of the Tre2 oncogene implicated in the Ewing's sarcoma.
Bach, Stéphane; Bouchat, Olivier; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie et de Biochimie (1998), 106

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See detailStudy of exo-beta-1,3-glucanase activity production by the yeast Pichia anomala in relation to its antagonistic properties against Botrytis cinerea on postharvest apples.
Grevesse, C.; Jijakli, Mohamed ULg; Lepoivre, Philippe ULg

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (1998), 63(4b), 1685-1682

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See detailStereoselective determination of S-naproxen in tablets by capillary electrophoresis.
Fillet, Marianne ULg; Fotsing, Lucas; Bonnard, J. et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 18(4-5), 799-805

A capillary electrophoresis (CE) method was developed for the stereoselective determination of the non-steroidal anti-inflammatory drug (NSAID), S-naproxen, in tablets. Several beta-cyclodextrin ... [more ▼]

A capillary electrophoresis (CE) method was developed for the stereoselective determination of the non-steroidal anti-inflammatory drug (NSAID), S-naproxen, in tablets. Several beta-cyclodextrin derivatives (CDs) were tested as chiral selectors, including sulfobutyl-beta-CD (SBCD), carboxymethyl-beta-CD (CMCD), dimethyl-beta-CD (DMCD) and trimethyl-beta-CD (TMCD), in a phosphoric acid/triethanolamine pH 3 buffer. Under these conditions, the analyte was mainly present in an uncharged form and therefore, the use a neutral CD (DMCD or TMCD) alone could not lead to enantiomeric separation. On the contrary, by addition of a charged CD (SBCD or CMCD) to the running buffer, giving the analyte enantiomers an adequate mobility, chiral resolution could be achieved, although the resolution values obtained in this case were not quite satisfactory (Rs < 1.5). Dual systems, based on the use of mixtures of charged and neutral CDs, were then investigated. The SBCD/TMCD system was found to be particularly well suited to the enantioseparation of naproxen and after optimisation of the concentrations of both CDs, a resolution value of 5.4 could be obtained. The method was validated for the determination of R-naproxen (enantiomeric impurity) in the 0.1-2% range, using the racemic mixture of the analyte. A second validation was performed in the 50-150% range for the quantitation of S-naproxen. In both cases, good results with respect to linearity, precision and accuracy were obtained. [less ▲]

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See detailEtude radiologique de l’os naviculaire normal. Partie 1: que penser des canaux sésamoïdiens du bord distal
Gabriel, Annick ULg; Jolly, S.; Detilleux, Johann ULg et al

in Annales de Médecine Vétérinaire (1998), 142

The scoring system based on the different types of navicular distal border canals is a good method to quantify and relativise the anomalies in number, shape and localisation of the canals. The distal ... [more ▼]

The scoring system based on the different types of navicular distal border canals is a good method to quantify and relativise the anomalies in number, shape and localisation of the canals. The distal border score varies significantly with the limb (fore or rear), the morphological type, the gender and the age of the horse. These anatomical variations are of importance and must be taken into account when examining a suspect bone. The score is larger for the fore navicular bone than for the rear. It could be interesting to compare both scores: rear navicular bone score is generally equal to half (or slight less) that of the fore. The score is larger for heavy types of horses and ponies (drafthorse, heavy halfbreds and Fjords). This phenomenon could be related to a larger pressure within the distal interphalangeal joint. The score is lower for the athletic half bred than for other halfbreds. This could be the result of the changes in bone architecture induced by exercise and particularly bone densification. The score is lower for the female than for the male. We think that navicular bone quality is better for the female and this idea corroborates that of other authors that consider that the risk to develop navicular disease is smaller for the female than for the male. The score increases with age. it is particularly small in young horses less than two years old and then increases strongly. This phenomenon is to be related to the progressive development, in the first year of life, of the groove between articular cartilage and distal impar ligament, canals developping only later one. In athletic horses, the score is higher between 7 and 12 years of age. During this time, we also observe more degenerative changes within the navicular bone, which could mean that bone is of lesser quality. [less ▲]

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See detailHsv-1 Thymidine Kinase Gene Therapy for Peritoneal Carcinomatosis
Lechanteur, Chantal ULg; Princen, Frédéric; Lo Bue, S. et al

in Advances in Experimental Medicine and Biology (1998), 451

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See detailCarbonic Anhydrase Ix, Mn/Ca Ix: Structure, Function And Involvement In Carcinogenesis
Pastorekova, S.; Kaluz, S.; Gibadulinova, A. et al

in Chemical Papers-Chemicke Zvesti (1998), 52

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See detailAtlas du recensement : une lecture plurielle de la Wallonie
Merenne-Schoumaker, Bernadette ULg

in Revue du Conseil Economique et Social de la Région wallonne (1998), (52), 31-35

Présentation de la Wallonie à la lumière du recensement de 1991. Cinq traits majeurs sont mis en évidence : - une dualité Flandre)-Wallonie réelle mais non dominante, - un processus majeur : l ... [more ▼]

Présentation de la Wallonie à la lumière du recensement de 1991. Cinq traits majeurs sont mis en évidence : - une dualité Flandre)-Wallonie réelle mais non dominante, - un processus majeur : l'urbanisation, - le poids du passé industriel, - la dualisation de la société, - des modèle culturels nouveaux [less ▲]

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See detailSpontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression injury of the rat.
Brook, G. A.; Plate, D.; Franzen, Rachelle ULg et al

in Journal of Neuroscience Research (1998), 53(1), 51-65

Spontaneous cellular reorganisation at the lesion site has been investigated following massive spinal cord compression injury in adult rats. By 2 days post operation (p.o.), haemorrhagic necrosis ... [more ▼]

Spontaneous cellular reorganisation at the lesion site has been investigated following massive spinal cord compression injury in adult rats. By 2 days post operation (p.o.), haemorrhagic necrosis, widespread axonal degeneration, and infiltration by polymorphnuclear granulocytes and OX42-positive macrophages were observed in the lesion site. By 7 days p.o., low affinity nerve growth factor receptor-positive Schwann cells, from activated spinal roots, were identified as they migrated far into the lesion. Between 7 and 14 days p.o., the overlapping processes of Schwann cells within the macrophage-filled lesion formed a glial framework which was associated with extensive longitudinally orientated ingrowth by many neurofilament-positive axons. Relatively few of these axons were calcitonin gene-related peptide (CGRP)-, substance P (SP)-, or serotonin (5HT)-positive; however, many were glycinergic or gamma aminobutyric acid (GABA)ergic. At 21 and 28 days p.o. (the longest survival times studied), a reduced but still substantial amount of orientated Schwann cells and axons could be detected at distances of up to 5 mm within the lesion. Glial fibrillary acidic protein (GFAP) immunoreactivity demonstrated the slow formation of astrocytic scarring which only became apparent at the lesion interface between 21 and 28 days p.o. The current data suggest the possibility of developing future therapeutic strategies designed to maintain or even enhance these spontaneous and orientated regenerative events. [less ▲]

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See detailThe antibiotic ceftazidime is a singlet oxygen quencher as demonstrated by ultra-weak chemiluminescence and by inhibition of AAP consumption.
Deby, Ginette ULg; Deby, C.; Mouithys-Mickalad, Ange ULg et al

in Biochimica et Biophysica Acta (1998), 1379(1), 61-8

We demonstrated that the cephalosporin antibiotic ceftazidime (CAZ) deactivated singlet oxygen (1O2). We then studied the mechanisms of the CAZ effects on the ultra weak chemiluminescence (uwCL ... [more ▼]

We demonstrated that the cephalosporin antibiotic ceftazidime (CAZ) deactivated singlet oxygen (1O2). We then studied the mechanisms of the CAZ effects on the ultra weak chemiluminescence (uwCL) associated with the energy decay of 1O2 generated by the Mallet reaction (H2O2 + HOCl --> HCl + H2O + 1O2), and on the anthracene-9,10-dipropionic acid (AAP) consumption by 1O2 generated by irradiation of Rose Bengal (RB). The uwCL generated by the Mallet reaction was amplified (6.2 times) by CAZ. The use of red and blue filters, which absorb radiation below 610 nm and between 470 and 700 nm respectively, demonstrated that CAZ increased the uwCL by a radiation emission at wavelengths shorter than the 633 and 704 nm wavelength emissions of 1O2. CAZ was excited by scavenging the energy excess of 1O2, which so returned to its fundamental state, while CAZ deactivated with light emission between 430-480 nm. CAZ also inhibited in a dose-dependent manner the consumption of AAP by 1O2 generated by the irradiation of RB. The protection of AAP by 5 x 10(-3) M CAZ was equivalent to that of 10(-3) M histidine and 3 X 10(-6) M sodium azide. This process of 1O2 deactivation will be useful in diseases characterized by an excessive PMN activation with a release of activated oxygen species. [less ▲]

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See detailPharma-clinics. Le medicament du mois. Premelle (oestrogenes conjugues + medroxyprogesterone).
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(10), 638-40

Premelle, commercialised by Wyeth-Lederle, is a combination of conjugated estrogens 0.625 mg and medroxyprogesterone acetate 5 mg which is indicated in the treatment of menopause-associated problems ... [more ▼]

Premelle, commercialised by Wyeth-Lederle, is a combination of conjugated estrogens 0.625 mg and medroxyprogesterone acetate 5 mg which is indicated in the treatment of menopause-associated problems, among which vasomotor symptoms, atrophic vaginitis and/or urethritis, and in the prevention and treatment of post-menopausal osteoporosis. It is presented in two formulations, Premelle cyclic 5 and Premelle 5. The former, in which the progestagen is only given during the last 14 out of 28 days of the treatment cycle, is accompanied by regular bleeding and thus preferably indicated during perimenopause whereas the latter, in which the progestagen is given continuously and results in amenorrhea, is mostly indicated after menopause in order to improve long-term compliance. [less ▲]

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See detailRadial tree-growth modelling with fuzzy regression.
Boreux, Jean-Jacques ULg; Gadbin-Henry, C.; Guiot, Joël et al

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (1998), 28(8), 1249-1260

A so-called fuzzy linear regression is used in dendroecology to model empirically tree growth as a function of a bioclimatic index representing the water stress, i.e., the ratio of actual ... [more ▼]

A so-called fuzzy linear regression is used in dendroecology to model empirically tree growth as a function of a bioclimatic index representing the water stress, i.e., the ratio of actual evapotranspiration to potential evapotranspiration. The response function predicts tree growth as (fuzzy) intervals, narrow in the domain where the bioclimatic index is most limiting and becoming progressively larger elsewhere. The method is tested with a population of Pinus pineaL. from the Provence region in France. It is shown that fuzzy linear regression gives results comparable with those obtained using a linear response function. The interval of credibility given by the fuzzy regression suggests that more precise expected growth is obtained for high water stress, which is typical of Mediterranean climate. Fuzzy linear regression can be also a method to test different hypotheses on several potential predictors when any further experimental approach is quite impossible as it is for trees in their natural environment. To sum up, fuzzy regression could be a first step before the construction of a kind of growth simulator adapted to different environments of a given species. In environmental sciences, the fuzzy response function thus appears to be an approach between the mechanistic and the statistical descriptive approaches. [less ▲]

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See detailMéningo-encéphalite granulomateuse à Aspergillus sp. chez une chienne Airedale Terrier de un an
Poncelet, Luc; Belayat, F.; Losson, Bertrand ULg et al

in Annales de Médecine Vétérinaire (1998)

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See detailRegulation of major histocompatibility complex class I expression by NF-kB-related proteins in breast cancer cells
Dejardin, Emmanuel ULg; Deregowski, Valérie; GREIMERS, Roland ULg et al

in Oncogene (1998)

Downregulation of MHC Class I antigens has been observed in many cancers and usually results from a decreased gene transcription. A reporter CAT gene dependent on the MHC Class I kB site or on a longer ... [more ▼]

Downregulation of MHC Class I antigens has been observed in many cancers and usually results from a decreased gene transcription. A reporter CAT gene dependent on the MHC Class I kB site or on a longer promoter is transactivated by NF-kB complexes contain- ing p65 or RelB. p100 as well as IkB-a are potent inhibitors of this transcription and p100 sequesters RelB and p65 complexes in the cytoplasm of breast cancer cells. However, although p100 is highly expressed in a number of breast cancer cell lines, MHC Class I antigen expression was observed on all the cell lines we analysed and could be further induced by stimulation with the cytokines IFN-g or TNF-a. Stable transfection of a unresponsive mutated IkB-a Ser 32-36 expression vector showed that TNF-a induced MHC Cl I expression in an NF-kB-dependent way while IFN-g did it independently of any NF-kB activation. [less ▲]

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See detailAtmungsmechanik beim Tier. 4. Mitteilung : Die diagnostische Aussagefähigkeit von Untersuchungen mit dem Impuls-Oszilloresistometrie-System (IOS) beim Kalb
Reinhold, Petra; Langenberg, Annelie; Lekeux, Pierre ULg

in Berliner und Munchener Tierarztliche Wochenschrift (1998), 111(7-8), 262-267

Taking methodological and physiological aspects into account (see Part 3), the impulse oscillometry system (IOS) was found to be sensitive to detecting and to quantifying clinically relevant changes in ... [more ▼]

Taking methodological and physiological aspects into account (see Part 3), the impulse oscillometry system (IOS) was found to be sensitive to detecting and to quantifying clinically relevant changes in respiratory mechanics in calves. Therefore, the complex respiratory impedance needs to be measured in terms of resistance and reactance within the frequency range between 5 Hz and 20 Hz. The behaviour of resistance and reactance in dependence of frequency allows to differentiate and to localise airway obstructions. Obstructions of upper (extrathoracic) airways were mainly characterised by a frequency independent increase in the resistance. Within the reactance curve, no change in the resonant frequency could be observed. In a peripheral airway obstruction both resistance and reactance changed. The most typical finding concerning resistance was that a negative frequency dependence occurred. The reactance became more negative. Following this, the resonant frequency increased. With progressive obstruction of the peripheral airways, the reactance became more informative than resistance. [less ▲]

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See detailAnalytical solution of a simple artificial lighting scheme to test any lighting software
Embrechts, Jean-Jacques ULg

in Computer Modeling & Simulation in Engineering (1998), 3(3)

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See detailA Rank-Based Nonparametric Method for Mapping Quantitative Trait Loci in Outbred Half-Sib Pedigrees: Application to Milk Production in a Granddaughter Design
Coppieters, Wouter ULg; Kvasz, A.; Farnir, Frédéric ULg et al

in Genetics (1998), 149(3), 1547-55

We describe the development of a multipoint nonparametric quantitative trait loci mapping method based on the Wilcoxon rank-sum test applicable to outbred half-sib pedigrees. The method has been evaluated ... [more ▼]

We describe the development of a multipoint nonparametric quantitative trait loci mapping method based on the Wilcoxon rank-sum test applicable to outbred half-sib pedigrees. The method has been evaluated on a simulated dataset and its efficiency compared with interval mapping by using regression. It was shown that the rank-based approach is slightly inferior to regression when the residual variance is homoscedastic normal; however, in three out of four other scenarios envisaged, i.e., residual variance heteroscedastic normal, homoscedastic skewed, and homoscedastic positively kurtosed, the latter outperforms the former one. Both methods were applied to a real data set analyzing the effect of bovine chromosome 6 on milk yield and composition by using a 125-cM map comprising 15 microsatellites and a granddaughter design counting 1158 Holstein-Friesian sires. [less ▲]

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See detailLes hypertensions artérielles d'origine endocrinienne.
Beckers, Albert ULg

in Tempo Médical (1998), 196

Les hypertensions artérielles d'origine endocrinienne représentent environ 3 à 5 % des hypertensions artérielles, parmi lesquelles les formes les plus sévères. Lors du diagnostic, une importance ... [more ▼]

Les hypertensions artérielles d'origine endocrinienne représentent environ 3 à 5 % des hypertensions artérielles, parmi lesquelles les formes les plus sévères. Lors du diagnostic, une importance particulière sera accordée à une sémiologie évocatrice. Une cause endocrinienne sera également activement recherchée dans les cas de mauvaises réponses au traitement classique de l'hypertension artérielle. [less ▲]

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See detailArbitrary Lagrangian-Eulerian formulation for element-free Galerkin method
Ponthot, Jean-Philippe ULg; Belytschko, Ted

in Computer Methods in Applied Mechanics & Engineering (1998), 152

Arbitrary Lagrangian-Eulerian (ALE) formulation of the Element Free Galerkin (EFG) method is presented. EFG is a meshless method for solving partial differential equations in which the trial and test ... [more ▼]

Arbitrary Lagrangian-Eulerian (ALE) formulation of the Element Free Galerkin (EFG) method is presented. EFG is a meshless method for solving partial differential equations in which the trial and test functions employed in the discretization process result from moving least square interpolants. The most significant advantage of the method is that it requires only nodes and a description of internal and external boundaries and interfaces, such as cracks, of the model: no element connectivity is needed. However, as for any discretization method, acceptable solutions can only be obtained for a sufficiently refined discretization. In dynamic fracture problems, where the crack path can be arbitrary, and is thus a priori unknown, this necessitates a refined discretization in large parts of the computational domain which can lead to prohibitive computation costs. ALE formulation allows to continuously relocate nodes on the computational domain. By combining EFG with ALE, it is thus possible, in a crack propagation problem, to refine locally the spatial discretization in the neighborhood of a propagating crack-tip. Results are presented for a wave propagation problem as well as for 2-D dynamic crack propagation problems. [less ▲]

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See detailEnhanced Efficiency Of A Targeted Fusogenic Peptide
Decout, A.; Labeur, C.; Goethals, M. et al

in Biochimica et Biophysica Acta-Biomembranes (1998), 1372(1), 102-16

Membrane targeting was investigated as a potential strategy to increase the fusogenic activity of an isolated fusion peptide. This was achieved by coupling the fusogenic carboxy-terminal part of the beta ... [more ▼]

Membrane targeting was investigated as a potential strategy to increase the fusogenic activity of an isolated fusion peptide. This was achieved by coupling the fusogenic carboxy-terminal part of the beta-amyloid peptide (Abeta, amino acids 29-40), involved in Alzheimer's disease, to a positively charged peptide (PIP2-binding peptide, PBP) interacting specifically with a naturally occurring negatively charged phospholipid, phosphatidylinositol 4, 5-bisphosphate (PIP2). Peptide-induced vesicle fusion was spectroscopically evidenced by: (i) mixing of membrane lipids, (ii) mixing of aqueous vesicular contents, and (iii) an irreversible increase in vesicle size, at concentrations five to six times lower than the Abeta(29-40) peptide. In contrast, at these concentrations the PBP-Abeta(29-40) peptide did not display any significant activity on neutral vesicles, indicating that negatively charged phospholipids included as targets in the membranes, are required to compensate for the lower hydrophobicity of this peptide. When the alpha-helical structure of the chimeric peptide was induced by dissolving it in trifluoroethanol, an increase of the fusogenic potential of the peptide was observed, supporting the hypothesis that the alpha-helical conformation of the peptide is crucial to trigger the lipid-peptide interaction. The specificity of the interaction between PIP2 and the PBP moiety, was shown by the less efficient targeting of the chimeric peptide to membranes charged with phosphatidylserine. These data thus demonstrate that the specific properties of both the Abeta(29-40) and the PBP peptide are conserved in the chimeric peptide, and that a synergetic effect is reached through chemical linkage of these two fragments. [less ▲]

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See detailSeasonal variations in time and space utilization by radio-tagged yellow eels Anguilla anguilla (L.) in a small stream
Baras, Etienne; Jeandrain, Denys ULg; Serouge, Benoît et al

in Hydrobiologia (1998), 371/372

Seven yellow eels (572–643 mm, 318–592 g) Anguilla anguilla (L.) were tagged with surgically implanted radio transmitters (activity circuit, 1.6–1.7 g) and tracked in the Awirs stream, a small (width <5 m ... [more ▼]

Seven yellow eels (572–643 mm, 318–592 g) Anguilla anguilla (L.) were tagged with surgically implanted radio transmitters (activity circuit, 1.6–1.7 g) and tracked in the Awirs stream, a small (width <5 m, depth from 0.1 to 1.2 m), densely populated (ca. 250 kg of eel ha−1) tributary of the Belgian River Meuse. The eels were positioned daily from late April to mid-August, and their diel activity was studied during twenty four 24-h cycles. During day-time, the eels were resting in rootwads or in crevices inside stone walls or in crevices in between rocks. They became more active in the late afternoon but generally did not leave their residence before sunset, except under overcast weather. Activity peaked during the first part of the night then progressively vanished, and always ended before sunrise. The area exploited during night-time never extended over more than 40 m2, except when the eel changed its residence. The intensity and timing of nocturnal activity and the extent of the daily activity area were dependent on water temperature (respectively P<0.0001, P<0.05 and P<0.0005), with eels showing little or no activity when the diurnal temperature did not exceed 13 _C. Eels showed higher agitation under full moon and maintained their activity later in the night (P<0.05). The eels showed restricted mobility, and occupied small stream areas (from 0.01 to 0.10 ha) in a non sequential mode, except for two fish which were displaced to the River Meuse by a spate in early June and were never recovered. The length and frequency of net daily journeys were higher (P = 0.005) at water temperatures above 16 _C in late May and June, which also corresponded to the period of immigration of eels from the River Meuse. This study thus shows that large yellow eels may adopt a highly sedentary lifestyle in a continental, fast flowing and densely populated environment, even at periods of the year when these stages usually show upstream migrations. [less ▲]

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See detailEvaluation of surgery procedures for tagging eel Anguilla anguilla (L.) with biotelemetry transmitters
Baras, Etienne; Jeandrain, Denys ULg

in Hydrobiologia (1998), 371/372

Externally attached telemetry transmitters are unsuitable to tag yellow eels Anguilla anguilla (L.), in streams where they exhibit cryptic life habits and hide in narrow cavities between rocks. We ... [more ▼]

Externally attached telemetry transmitters are unsuitable to tag yellow eels Anguilla anguilla (L.), in streams where they exhibit cryptic life habits and hide in narrow cavities between rocks. We evaluated the adequacy of surgical implantation and closing procedures for tagging eels with biotelemetry transmitters. Epoxy dummy transmitters (18_8 mm, 1.6–1.7 g) were implanted in eels anaesthetised with 2-phenoxy-ethanol (0.9 ml l−1), through a 20mm mid ventral incision made in the posterior quarter of their body cavity. The incision was either left open, or closed in different ways: stitches (absorbable or non absorbable suture material) or commercial-grade cyanoacrilate adhesive (LoctiteTM). Fish were stocked in a 4 m2 flow through tank (15–17 _C), controlled daily for mortality and weekly for evaluating the healing process. No transmitter was expelled over a 12-week period, even in eels with unclosed incisions, of which 50% healed within 28 days (t50). Regardless of the nature of the filament, suturing induced skin and muscle necrosis, caused significantly higher mortality rates (60% after 10 weeks) and paradoxically slowed down the healing rate (40 and 45 d, respectively). Cyanoacrilate suppressed the inflammatory response and granted higher survival rate (90%), but did not permit to speed up the closing process (t50 = 52 d), as eels actively bit and removed the adhesive within hours. This behaviour was suppressed when we applied a freshly cut fragment of the eel dorsal fin as a biological bandage over the drying cyanoacrilate. The adhesive remained in place for one to two days and permitted to substantially increase the healing rate (t50 = 15 d). These results substantiate the efficiency of surgery techniques for tagging eels with radio transmitters, at least for units of small weight and bulk. [less ▲]

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See detailLes liens sociaux entre dirigeants et le déclenchement de la coopération interentreprises
Froehlicher, Thomas ULg

in Finance Contrôle Stratégie (1998)

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See detailDépression et suicide : Aspects biologiques
ANSSEAU, Marc ULg; PITCHOT, William ULg

in Neuro-psy (1998)

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See detailEffect Of Drying On Bioremediation Bacteria Properties
Weekers, F.; Jacques, Philippe ULg; Springael, D. et al

in Applied Biochemistry and Biotechnology (1998), 70-2

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See detailThe prediction of preeclampsia: Reassessment of clinical value of increased plasma levels of fibronectin
Dreyfus, M.; Baldauf, J. J.; Ritter, J. et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (1998), 78

Objective: To determine whether assessment of plasma fibronectin in primigravidae could predict the pregnant women expected to become preeclamptic. Methods: We performed a prospective blinded analysis of ... [more ▼]

Objective: To determine whether assessment of plasma fibronectin in primigravidae could predict the pregnant women expected to become preeclamptic. Methods: We performed a prospective blinded analysis of 156 apparently normotensive primigravidae in an outpatient clinic. Blood samples were taken at 6 week intervals from the 18th week and immediately after delivery or at the onset of preeclampsia. Plasma fibronectin was evaluated by ELISA. Evolution with gestational age was studied using regression curves. Results: We had 148 normal primigravidae (592 determinations). In three women, increased fibronectin anticipated preeclampsia by 3–4 weeks. Five women showed high levels only at the onset of preeclampsia. Sensitivity, specificity, positive and negative predictive values of increased fibronectin levels were 37.5% (95% CI53.3–71.7), 96.6% (95% CI593.7–99.6), 37.5% (95% CI53.3–71.7) and 96.6% (95% CI593.7–99.6), respectively. Conclusions: This study shows that plasma fibronectin levels could represent a specific marker for preeclampsia. Its sensitivity has to be improved but its high negative predictive value strongly argues against the development of preeclampsia within the next 4 weeks after the blood sampling. [less ▲]

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See detailRésistance aux antibiotiques de souches d'Escherichia coli bovines et aviaires isolées en Algérie
Mellata, M.; Jacquemin, E.; Bakour, R. et al

in Annales de Médecine Vétérinaire (1998), 142

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See detailNéoplasie mammaire plurifocale en généralisation osseuse
Blocklet, Didier; Seret, Alain ULg; Schoutens, André

in Revue Médicale de Bruxelles (1998), 19

Clinical case.

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See detailL'hépatite E
Delwaide, Jean ULg; Gerard, Christiane ULg

in Les Hépatites virales, Roche (1998)

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See detailTranscriptional activation capacity of the novel PLAG family of zinc finger proteins.
Kas, K.; Voz, Marianne ULg; Hensen, K. et al

in Journal of Biological Chemistry (1998), 273(36), 23026-32

We have isolated and characterized two novel cDNAs encoding C2H2 zinc finger proteins showing high sequence homology to PLAG1, a protein ectopically activated by promoter swapping or promoter substitution ... [more ▼]

We have isolated and characterized two novel cDNAs encoding C2H2 zinc finger proteins showing high sequence homology to PLAG1, a protein ectopically activated by promoter swapping or promoter substitution in pleomorphic adenomas with chromosomal abnormalities at chromosome 8q12. PLAG1 and the two new PLAG1 family members (PLAGL1 and PLAGL2) constitute a novel subfamily of zinc finger proteins that recognize DNA and/or RNA. To examine the potential of the three human proteins to modulate transcription, we constructed several PLAG/GAL4 DNA binding domain fusion proteins and measured their ability to activate transcription of a reporter gene construct in different mammalian cell lines and in yeast. Although the carboxyl-terminal part of PLAGL1 shows strong overall transcriptional activity in mesenchymal (COS-1) and epithelial cells (293), both PLAG1 and PLAGL2 transactivate in mesenchymal cells only if depleted from a repressing region. This effect is less profound in epithelial cells. These data suggest that the activation in pleomorphic adenomas of PLAG1 most likely results in uncontrolled activation of downstream target genes. [less ▲]

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See detailAb initio phonon dispersion curves and interatomic force constants of barium titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1998), 206(1-4), 205-217

The phonon dispersion curves of cubic BaTiO3 have been computed within a first-principles approach and the results compared to the experimental data. The curves obtained are very similar to those reported ... [more ▼]

The phonon dispersion curves of cubic BaTiO3 have been computed within a first-principles approach and the results compared to the experimental data. The curves obtained are very similar to those reported for KNbO3 by Yu and Krakauer (Phys. Rev. Lett., 74, 4067 (1995)). They reveal that correlated atomic displacements along [100] chains are at the origin of the ferroelectric instability. A simplified model illustrates that spontaneous collective displacements will occur when a dozen of aligned atoms are coupled. The longitudinal interatomic force constant between nearest neighbour Ti and O atoms is relatively weak in comparison to that between Ti atoms in adjacent cells. The small coupling between Ti and O displacements seems however necessary to reproduce a linear ferroelectric instability. [less ▲]

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See detailDynamical atomic charges: The case of ABO(3) compounds
Ghosez, Philippe ULg; Michenaud, J. P.; Gonze, X.

in Physical Review. B : Condensed Matter (1998), 58(10), 6224-6240

Based on recent first-principles computations in perovskite compounds, especially BaTiO3, we examine the significance of the Born effective charge concept and contrast it with other atomic charge ... [more ▼]

Based on recent first-principles computations in perovskite compounds, especially BaTiO3, we examine the significance of the Born effective charge concept and contrast it with other atomic charge definitions, either static (Mulliken, Bader, etc.) or dynamical (Callen, Szigeti, etc.). It is shown that static and dynamical charges are not driven by the same underlying parameters. A unified treatment of dynamical charges in periodic solids and large clusters is proposed. The origin of the difference between static and dynamical charges is discussed in terms of local polarizability and delocalized transfers of charge: local models succeed in reproducing anomalous effective charges thanks to large atomic polarizabilities but, in ABO(3) compounds, ab initio calculations favor the physical picture based upon transfer of charges. Various results concerning barium and strontium titanates are presented. The origin of anomalous Born effective charges is discussed thanks to a band-by-band decomposition which allows us to identify the displacement of the Wannier center of separated bands induced by an atomic displacement. The sensitivity of the Born effective charges to microscopic and macroscopic strains is examined. Finally, we estimate the spontaneous polarization in the four phases of barium titanate. [less ▲]

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See detailMRI of a presumptive trigeminal nerve tumor in a seven years old husky dog : a case report and review of the litterature
Saunders, J.; Clercx, Cécile ULg; Poncelet, Luc et al

in Veterinary Radiology & Ultrasound (1998), 39

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See detailExtended Irreversible Thermodynamics Revisited ( 1988-1998)
Jou, David; Casas-Vazquez, Jose; Lebon, Georgy ULg

in Report in progress in physics (1998), 62

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See detailLesions of morbillivirus infection in a fin whale (Balaenoptera physalus) stranded along the Belgian coast
Jauniaux, Thierry ULg; Charlier, G.; Desmecht, M. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(15), 423-424

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See detailInsulin-like growth factor-I (IGF-I), IGF-binding proteins synthesis, and thyroid status are affected by dexamethasone esters treatment in finishing calves
Bertozzi, Carlo; Massart, Serge; Prandi, Alberto et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 45

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See detailEvaluation of a weight-adjusted single-bolus plasminogen activator in patients with myocardial infarction: a double-blind, randomized angiographic trial of lanoteplase versus alteplase.
den Heijer, P.; Vermeer, F.; Ambrosioni, E. et al

in Circulation (1998), 98(20), 2117-25

BACKGROUND: Lanoteplase (nPA) is a rationally designed variant of tissue plasminogen activator with greater fibrinolytic potency and slower plasma clearance than alteplase. METHODS AND RESULTS: InTIME ... [more ▼]

BACKGROUND: Lanoteplase (nPA) is a rationally designed variant of tissue plasminogen activator with greater fibrinolytic potency and slower plasma clearance than alteplase. METHODS AND RESULTS: InTIME (Intravenous nPA for Treatment of Infarcting Myocardium Early), a multicenter, double-blind, randomized, double-placebo angiographic trial, evaluated the dose-response relationship and safety of single-bolus, weight-adjusted lanoteplase. Patients (n=602) presenting within 6 hours of acute myocardial infarction were randomized and treated with either a single-bolus injection of lanoteplase (15, 30, 60, or 120 kU/kg) or accelerated alteplase. The primary objective was to determine TIMI grade flow at 60 minutes. Angiographic assessments were also performed at 90 minutes and on days 3 to 5. Follow-up was continued for 30 days. Lanoteplase achieved its primary objective, demonstrating a dose-response in TIMI grade 3 flow at 60 minutes (23.6% to 47.1% of subjects, P<0. 001). Similar results were observed at 90 minutes (26.1% to 57.1%, P<0.001). At 90 minutes, coronary patency (TIMI 2 or 3) increased across the dose range up to 83% of subjects at 120 kU/kg lanoteplase compared with 71.4% with alteplase. Thus, at this dose, lanoteplase was superior to alteplase in restoring coronary patency (difference, 12%; 95% CI, 1% to 23%). The early safety experience in this study suggests that lanoteplase was well tolerated at all doses with safety comparable to that of alteplase. CONCLUSIONS: Lanoteplase, a single-bolus, weight-adjusted agent, increased coronary patency at 60 and 90 minutes in a dose-dependent fashion. Coronary patency at 90 minutes was achieved more frequently with 120 kU/kg lanoteplase than alteplase. In this study, safety with lanoteplase and alteplase was comparable. InTIME-II, a worldwide mortality trial, will evaluate efficacy and safety with this promising new agent. [less ▲]

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See detailnote sous C. Arbitrage, 11 décembre 1996
Moreau, Pierre ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederechters (1998)

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See detailDu théâtre et de la politique selon Jean-Marie Piemme
Delhalle, Nancy ULg

in Alternatives Théâtrales (1998)

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See detailPopular Modernism and The American Prose Poem : From Sherwood Anderson to Kenneth Patchen
Delville, Michel ULg

in The Prose Poem : an International Journal (1998), 7

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See detailA collapsed intermediate with nonnative packing of hydrophobic residues in the folding of TEM-1 beta-lactamase
Vanhove, M.; Lejeune, Annabelle ULg; GUILLAUME, G. et al

in Biochemistry (1998), 37(7), 1941-1950

The kinetics of refolding of TEM-1 beta-lactamase from solution in guanidine hydrochloride have been investigated on the manual and stopped-flow mixing time scales. The kinetics of change of far-UV ... [more ▼]

The kinetics of refolding of TEM-1 beta-lactamase from solution in guanidine hydrochloride have been investigated on the manual and stopped-flow mixing time scales. The kinetics of change of far-UV circular dichroism and of intrinsic and ANS fluorescence have been compared with changes in the quenching of fluorescence by acrylamide as a probe of the accessibility of solvent to tryptophan. The binding of ANS points to hydrophobic collapse in the very early stages of folding which take place in the burst phase. This is accompanied by regain of 60-65% of-native ellipticity, indicating formation of a significant proportion of secondary structure, Also in the burst phase, the tryptophan residues, which are largely exposed to solvent in the native protein, become less accessible to acrylamide, and the intrinsic fluorescence increases markedly. An early intermediate is thus formed in which tryptophan is more buried than in the native protein. Further intermediates are formed over the next 20 s. Quenching by acrylamide increases during this period, as the transient nonnative state is disrupted and the tryptophan residue(s) become(s) reexposed to solvent, The two slowest phases are determined by the isomerization of incorrect prolyl isomers, but double jump tryptophan fluorescence and acrylamide quenching experiments show little, if any, effect of proline isomerization on the earlier phases, Hydrophobic collapse thus occurs to a folding intermediate in which there is a nonnative element of structure which has to rearrange in the later steps of folding, resulting in a nonhierarchical folding pathway. The C-terminal W290 is suggested as being involved in the nonnative intermediate. beta-Lactamase provides further evidence for the occurrence of nonnative intermediates in protein folding. [less ▲]

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See detailProjet Solidarité : Accompagnement d'équipes éducatives dans la réalisation de leur projet d'établissement
Lenoir, A.; Mouvet, Bernadette ULg; Munten, J. et al

in Point sur la Recherche en Education (Le) (1998), 8

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See detailDoes an Acute COPD Crisis Modify the Cardiorespiratory and Ventilatory Adjustments to Exercise in Horses?
Art, Tatiana ULg; Duvivier, Dominique Hannia; Votion, Dominique ULg et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1998), 84(3), 845-52

The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD ... [more ▼]

The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD horses were submitted to a standardized submaximal treadmill exercise test while they were in clinical remission or in acute crisis. Respiratory airflow, O2 and CO2 fractions in the respired gas, pleural pressure changes and heart rate were recorded, and arterial and mixed venous blood were analyzed for gas tensions, hemoglobin, and plasma lactate concentrations. O2 consumption, CO2 production, expired minute ventilation, tidal volume, alveolar ventilation, cardiac output, total pulmonary resistance, and mechanical work of breathing were calculated. The results showed that, when submaximally exercised, COPD horses in crisis were significantly more hypoxemic and hypercapnic and that their total pulmonary resistance and mechanical work of breathing were significantly higher and their expired minute ventilation significantly lower than when they were in remission. However, their O2 consumption remained unchanged, which was probably due to the occurrence of compensatory mechanisms, i.e., higher heart rate, cardiac output, and hemoglobin concentration. Last, their net anaerobic metabolism seemed to be more important. [less ▲]

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See detailDestabilization Of A Model Membrane By A Predicted Fusion Peptide Of Fertilin Alpha
Schanck, A.; Brasseur, Robert ULg; Peuvot, J.

in Journal de Chimie Physique et de Physico-Chimie Biologique (1998), 95(2), 467-73

The subunit a of the guinea pig fertilin (previously known as PH-30, an integral membrane protein involved in sperm-egg binding and fusion) is predicted to be a potential fusion protein.The structure of ... [more ▼]

The subunit a of the guinea pig fertilin (previously known as PH-30, an integral membrane protein involved in sperm-egg binding and fusion) is predicted to be a potential fusion protein.The structure of this putative fusion protein was analysed by molecular modeling and we have found a peptidic sequence of 17 residues (D83-P99) organized in helix that inserts obliquely in lipid phases. The effect of ths synthesized peptide was studied on a model membrane by 3lP NMR and light scattering. It appears to increase the size of lipid vesicles and induces structural odifications. We interpret these observations as a destabilization of the lipid organization by this peptide because of its tilted insertion in phospholipid layers. This destabilization could favor membrane fusion. [less ▲]

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See detailCompte rendu de N.-Y. TONNERRE, Naissance de la Bretagne
George, Philippe ULg

in Moyen Age (Le) (1998)

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See detailLe cartilage articulaire peut-il se régénérer ?
Henrotin, Yves ULg; Reginster, Jean-Yves ULg

in Le Journal du Médecin (1998), 1129

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See detailRecherches en Pédagogie des Activités physiques et sportives centrées sur l'enseignement primaire et secondaire. Thèmes, principes méthodologiques et implications didactiques
Piéron, Maurice ULg; Cloes, Marc ULg

in Revue de l'Education Physique (1998), 38(3), 109-125

Tout service universitaire compte parmi ses missions celle de développer la connaissance du domaine au moyen d'une recherche structurée. On sait qu'enseignement et recherche se nourrissent mutuellement ... [more ▼]

Tout service universitaire compte parmi ses missions celle de développer la connaissance du domaine au moyen d'une recherche structurée. On sait qu'enseignement et recherche se nourrissent mutuellement. La pédagogie des activités physiques et sportives ne fait évidemment pas exception, même si elle ne possède aucun caractère prioritaire dans les organismes qui financent la recherche. ... [less ▲]

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See detailUn acceso de fiebre milenarista
Richelle, Marc ULg

in Anuario de Psicologia (1998), 29(2), 5-19

As an introduction to the present thematic issue of the Anuario de Psicología, the author, indulging in the millenarist mood at the approach of the year 2000, presents some reflections on the present ... [more ▼]

As an introduction to the present thematic issue of the Anuario de Psicología, the author, indulging in the millenarist mood at the approach of the year 2000, presents some reflections on the present state of psychology and on future prospects. In spite of the fragmentation of psychology into multiple subfields, he points to some signs towards recovering unity. Attention is given especially to current trends towards restoring the importance of emotion and motivation, of action and of environment factors, the place of which had been reduced or neglected by extreme cognitivism. Although the traditional conflict as to the roots - biological or cultural - of human nature is far from being solved, a new way to look at variations, both interindividual and intraindividual, offers a possibility to reconcile the biological and socio-historical dimensions, and also to face the many problems challenging applied psychology in the future. Emphasis is made on the increasing need for pluridisciplinary, for better communication within psychology, for more efficient and earlier information and education of the public at large as what psychology is about. Given the impossibility to predict what changes human nature might undergo during the next centuries, recommandations are made to maximal flexibility, and readiness to deal with humans fully shaped by virtual reality, eventually in need of virtual psychologists. [less ▲]

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