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See detailAcute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study.
Dahchour, Abdelkhader; Quertemont, Etienne ULg; De Witte, Philippe

in Alcohol & Alcoholism (1994), 29(5), 485-7

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain ... [more ▼]

The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain nucleus accumbens were studied by the microdialysis technique coupled to HPLC-EC detection. Levels of GLU and GABA were not affected by ethanol, whereas those of TAU were increased by doses of the drug of 2-3 g/kg. [less ▲]

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See detailWorking memory in Down's syndrome: Training the rehearsal strategy
Comblain, Annick ULg

in Down's Syndrome, Research and Practice : The Journal of the Sarah Duffen Centre (1994), 2(3), 123-126

This study reports on the verbal short term memory skills of individuals with Down's syndrome and on the possibility of increasing memory span durably by using a rehearsal strategy

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See detailBovine Growth Hormone-Taqi Rflp And Quantitative Traits Breed Selected For Growth Performances And Meat Production
Sneyers, M.; Renaville, Robert ULg; Falaki, M. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1994), 102(2),

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See detailDNase I hypersensitive sites far upstream of the rat tryptophan oxygenase gene direct developmentally regulated transcription in livers of transgenic mice.
Kaltschmidt, Christian; Muller, Marc ULg; Brem, Gottfried et al

in Mechanisms of Development (1994), 45(3), 203-10

Expression of the gene coding for tryptophan oxygenase (TO) is switched on in rat liver about two weeks after birth. We identified two clusters of DNaseI hypersensitive (HS) sites in the TO gene upstream ... [more ▼]

Expression of the gene coding for tryptophan oxygenase (TO) is switched on in rat liver about two weeks after birth. We identified two clusters of DNaseI hypersensitive (HS) sites in the TO gene upstream region; one near the promoter, the other at a distant upstream location (-8.5 kb). Hypersensitivity of upstream sites was present in adult and in 7 day old rat liver, but absent in kidney. To investigate their role in transcriptional regulation, a reporter gene controlled by both HS site regions was used to generate transgenic mice. In these animals the transgene followed the cell specific and developmental regulation of the endogenous gene: inactive after birth and active in adult liver. Transgenes containing only the promoter proximal HS site were non-functional. [less ▲]

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See detailCoût dans le secteur de la distribution d'eau en Wallonie et à Bruxelles : estimation d'une fonction de coût hédonique
Evrard, Olivier; Lejeune, Bernard ULg; Thiry, Bernard

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (1994), 65(2), 333-360

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See detailLigamentoplasties du genou: l'état musculaire préopératoire conditionne t il le degré d'amyotrophie postopératoire?
Croisier, Jean-Louis ULg; Delcour, J. P.; Crielaard, Jean-Michel ULg

in Annales de Réadaptation et de Médecine Physique (1994), 37

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See detailEssai sur le rythme statuaire à la période protohistorique en Mésopotamie
Tunca, Önhan ULg

in Beiträge zur Altorientalischen Archäologie und Altertumskunde (1994)

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See detailUne contrefaçon liégeoise exemplaire : les Œuvres du philosophe bienfaisant (1764)
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1994), 265

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See detailHST-FOC observations of a remarkable UV auroral event on Jupiter
Gérard, Jean-Claude ULg; Grodent, Denis ULg; Prangé, R. et al

in NASA STI/Recon Technical Report N (1994), 95

Two sets of UV (ultraviolet) images of the Jovian north aurora were obtained with the Faint Object Camera (FOC) on Hubble. The first series shows a very intense discrete arc in corotation with the planet ... [more ▼]

Two sets of UV (ultraviolet) images of the Jovian north aurora were obtained with the Faint Object Camera (FOC) on Hubble. The first series shows a very intense discrete arc in corotation with the planet. The maximum apparent H2 emission rate corresponds to an electron precipitation of approximately 1/sq Wm, a very large flux in comparison with the solar EUV (extreme ultraviolet) heating. The hugh particle heating rate of the auroral upper atmosphere of Jupiter is expected to cause a large transient temperature increase and generate strong thermospheric winds. Twenty hours later, the discrete arc had considerably decreased in brightness. The timescale and magnitude of the change in the UV aurora strongly suggests that the discrete Jovian auroral precipitation is related to large scale current system variations as are the Earth's discrete aurorae. [less ▲]

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See detailEffects of Atmospheric Ammonia on Pulmonary Hemodynamics and Vascular Permeability in Pigs: Interaction with Endotoxins
Gustin, Pascal ULg; Urbain, B.; Prouvost, J. F. et al

in Toxicology and Applied Pharmacology (1994), 125(1), 17-26

The influence of atmospheric ammonia on the somatic growth, the plasma cortisol and ammonia concentrations, and cell blood counts was investigated in pigs exposed to four concentrations (0, 25, 50, and ... [more ▼]

The influence of atmospheric ammonia on the somatic growth, the plasma cortisol and ammonia concentrations, and cell blood counts was investigated in pigs exposed to four concentrations (0, 25, 50, and 100 ppm) for 6 days in a specifically designed air-pollutants exposure chamber. The effects of this gas on pulmonary vascular hemodynamics and permeability and on the endotoxin-induced vascular response were also assessed using an isolated perfused lung preparation. The total pulmonary blood flow resistance (Rt) was partitioned into four components: arterial (Ra), pre-(Ra′) and post-(Rv′) capillary and venous (Rv). The capillary filtration coefficient (Kf,c) was evaluated by using a gravimetric technique. None of the concentrations of ammonia significantly modified the plasma cortisol and ammonia concentrations or the differential leukocyte percentages and total white blood cell count, suggesting an absence of stress related to ammonia. In exposed animals, lethargy and a concentration-related depression of the somatic growth were observed. The equation of the regression line plotted relating the mean values of the changes in body weight gain recorded over the exposure period expressed as percentages of the initial body weight (y) and ammonia concentrations (x) was: y = 3.204 − 0.177x + 0.001x2(r = 0.99; p≤0.013). Endotoxin infused in the perfusion liquid of lungs from unexposed animals for 180 min induced a significant 208% increase in Rt (p < 0.001) which can be ascribed to a 338 and 180% increase in Ra′ and Rv′, respectively. Endotoxin infusion also induced a 62% (p ≤ 0.001) increase in the Kf,c. Exposure of pigs to ammonia at any concentration did not modify the baseline values of any hemodynamic or permeability parameters. However, the hemodynamic response to endotoxins in lungs from pigs exposed to 100 ppm was significantly altered. The increase in Rt, Ra′, and Rv′ observed in unexposed pigs was completely abolished as shown by the limited changes in Rt (+34.9%). An intermediate reaction (+131.7%) was obtained in pigs exposed to 50 ppm. This inhibiting effect of ammonia was closely correlated with gas concentration by a linear regression (r = 0.99; p ≤ 0.037). The changes in the Kf,c recorded in the control group were not modified by exposure to ammonia. It was concluded that exposure of pigs to aerial ammonia concentrations from 0 to 100 ppm for 6 days has no direct effect on the pulmonary microvascular hemodynamics and permeability and induces no stress response. A marked depressive effect on the somatic growth is observed at concentrations greater than 25 ppm. Concentrations greater than 50 ppm can modulate the pulmonary vascular response to endotoxins [less ▲]

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See detailMassive Ketonuria During Sedation with Propofol in a 12 Year Old Girl with Severe Head Trauma
Canivet, Jean-Luc ULg; Gustad, K.; Leclercq, P. et al

in Acta Anaesthesiologica Belgica (1994), 45(1), 19-22

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial ... [more ▼]

Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial hypertension; as a part of our management protocol, glucose intake was restricted to 5 Kcal/h. After 18 hours of propofol infusion there was intense ketonuria (8+ by Ketostix) without any evidence of metabolic acidosis (pH, HCO3- and anion gap were within normal values). At this time, indirect calorimetry (Deltatrac) confirmed that energy expenditure was principally based on fat consumption (70% of energy expenditure). Lowering the propofol infusion rate and increasing glucose intake reduced fat consumption to 39% within 8 hours: at this time, Ketostix was negative for ketone bodies. This case illustrates a potential risk of ketonuria during prolonged sedation with propofol (a 10% solution of intralipid), particularly if glucose intake is restricted. Monitoring urinary ketone bodies is recommended under these circumstances. [less ▲]

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See detailRelationships between metabolic clearance rate of insulin and body mass index in a female population ranging from anorexia nervosa to severe obesity.
Castillo, M. J.; Scheen, André ULg; Jandrain, Bernard ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1994), 18(1), 47-53

Changes in the metabolic clearance rate of insulin (MCRI) have been described in several pathological conditions. Conflicting data suggest that they may be related to either body mass index (BMI) or body ... [more ▼]

Changes in the metabolic clearance rate of insulin (MCRI) have been described in several pathological conditions. Conflicting data suggest that they may be related to either body mass index (BMI) or body composition. This study aimed to investigate the relationship between the MCRI and BMI in an exclusively female population showing a wide range of BMI. For that purpose, hyperinsulinemic normoglycemic glucose clamps were performed in nine anorectic subjects (BMI: 14.5 +/- 0.8 kg/m2), 11 healthy volunteers (BMI: 20.3 +/- 0.5 kg/m2) and 12 obese patients (BMI: 33.0 +/- 0.9 kg/m2). To exclude any influence of the menstrual cycle on the MCRI, five healthy women underwent three tests at different days of the menstrual cycle: menstruation period, late follicular pre-ovulatory phase and luteal phase, in random order. The MCRI, which was quite reproducible in a given subject, was not significantly modified by the menstrual cycle. In the premenopausal female population studied, the mean (+/- s.e.m.) MCRI normalized for body weight (kg) were 35.4 +/- 3.4, 24.7 +/- 1.8 and 14.0 +/- 1.0 ml/kg/min (P < 0.01) for anorectic subjects, healthy volunteers and obese patients, respectively. These differences were maintained when the MCRI was normalized according to corporeal surface (m2) (1018 +/- 75, 859 +/- 67, 638 +/- 40 ml/m2/min, P < 0.01) or lean body mass (kg) (37.1 +/- 3.4, 32.6 +/- 2.7 and 24.1 +/- 0.5 ml/kgLBM/min, P < 0.01), but disappeared when MCRI was expressed per kg of ideal body weight (24.6 +/- 2.2, 24.6 +/- 2.1 and 22.4 +/- 1.4 ml/kgIBW/min, n.s.).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailFirst-principles calculations of dielectric and effective charge tensors in Barium Titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1994), 153

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See detailCompte rendu de V. Langholf, Medical Theories in Hippocrates, Berlin-New York, 1990
Marganne, Marie-Hélène ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1994), 63

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See detailMR1325693,Huang, Hou-Cheng and Usmani, Asif S.,Finite element analysis for heat transfer
Rochus, Pierre ULg

in Mathematical Reviews [=MR] (1994)

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See detailCompte-rendu de l'ouvrage de Vincent de Gaulejac et d'Isabel Taboada Leonnetti: La lutte des places
Robert, Jocelyne ULg

in Revue de l'Institut de Sociologie (1994)

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See detailDistribution and Regulation of Estrogen-2-Hydroxylase in the Quail Brain
Balthazart, Jacques ULg; Stoop, R.; Foidart, Agnès ULg et al

in Brain Research Bulletin (1994), 35(4), 339-45

The anatomical distribution and endocrine regulation of the estrogen-2-hydroxylase activity were investigated in the brain of adult male and female Japanese quail. Significant levels of enzymatic activity ... [more ▼]

The anatomical distribution and endocrine regulation of the estrogen-2-hydroxylase activity were investigated in the brain of adult male and female Japanese quail. Significant levels of enzymatic activity were detected in all brain regions that were studied, but the highest levels were observed in preoptic and hypothalamic brain nuclei that are known to contain high levels of aromatase activity. These data are consistent with previous results suggesting that the placental aromatase is also responsible for the estrogen-2-hydroxylase activity. However, there is a marked sex difference and a control by T of aromatase activity in the quail brain, and no such difference in 2-hydroxylase activity could generally be detected except in the VMN. Further studies will be needed to know whether the previously published conclusions concerning the human placenta also apply to the brain. The present data are consistent with the idea that estrogens formed locally in the brain by testosterone aromatization could affect reproduction by interfering with the catecholaminergic transmission after being metabolized into catechol-estrogens. [less ▲]

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See detailBehavioural study of hybridization between Barbus barbus and Barbus meridionalis
Poncin, Pascal ULg; Jeandarme, J.; Berrebi, P.

in Journal of Fish Biology (1994), 45

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See detailTEMPERATURE-DEPENDENCE OF GROWTH, ENZYME-SECRETION AND ACTIVITY OF PSYCHROPHILIC ANTARCTIC BACTERIA
Feller, Georges ULg; Narinx, E.; Arpigny, J. L. et al

in Applied Microbiology & Biotechnology (1994), 41(4), 477-479

Five psychrophilic Antarctic bacteria have been selected for their capacity to secrete exoenzymes into culture medium. These strains are able to grow from 0 to about 25 degrees C. However, production of ... [more ▼]

Five psychrophilic Antarctic bacteria have been selected for their capacity to secrete exoenzymes into culture medium. These strains are able to grow from 0 to about 25 degrees C. However, production of lipase from Moraxella, alpha-amylase from Alteromonas haloplanctis, beta-lactamase from Psychrobacter immobilis and protease from Bacillus is maximal at temperatures close to that of their environment (-2 to 4 degrees C) and is strongly inhibited at higher temperatures. This thermal effect involves alterations in the secretory pathway in the upper range of temperatures, losses due to the enzyme thermal lability and in some cases to reduction in cell development. The apparent optimal activity temperature of these enzymes is between 30 and 40 degrees C, i.e. about 20 degrees C lower than that of their mesophilic counterparts. [less ▲]

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See detailT-CELLS SKIN LYMPHOMA IN 3 DOGS
Gilbert, S.; Clercx, Cécile ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1994), 138(8), 587-595

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See detailUn formalisme unique peut-il décrire les phénomènes acoustiques et lumineux ?
Embrechts, Jean-Jacques ULg

in Bulletin d'Acoustique (1994), 16

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See detailMeasurement of Right Ventricular Ejection Fraction and Volume by the Thermodilution Technique in the Unsedated Calf
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1994), 56(1), 75-81

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end ... [more ▼]

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in unsedated cattle. In the 16 healthy calves studied, it was possible, using a fast response thermodilution catheter, to obtain characteristic exponential steplike washout curves, allowing the calculation of right ventricular EF, EDV and ESV. Five to 10 successive thermodilution curves were recorded within a few minutes and two to five similar sets of measurements were performed throughout the same day to test the reproducibility of the technique. The same protocol was repeated the following day. Right ventricular EF, EDV and ESV were reproducible successively, throughout a given day and on following days. The mean intraset, intraday and interdays coefficients of variation ranged from a mean of 4.0 (SD 4.1) per cent to a mean of 18.2 (SD 7.9) per cent. Values of right ventricular volumes and EF agreed with those previously reported in various animal species. Thermodilution was, therefore, shown to be a useful method for measuring with a satisfactory reproducibility, right ventricular EF, EDV and ESV in the unsedated healthy calf [less ▲]

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See detailPilgrimage out of Dispossession
Pagnoulle, Christine ULg

in Commonwealth : Essays and Studies (1994), 17(1), 100-106

Goodison's poems testify to her proud self-assertion, both as woman and as a descendant of African slaves.

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See detailL’expérience pédagogique: «Rénovation de l’enseignement fondamental - Développement corporel des enfants de 21/2 ans à 12 ans».
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Informations pédagogiques (1994), 10

Delmelle (1992) a clairement défini la philosophie général de l'expérience pédagogique: "Compte tenu des besoins, des structures administratives en vigueur, des disponibilités matérielles et humaines et ... [more ▼]

Delmelle (1992) a clairement défini la philosophie général de l'expérience pédagogique: "Compte tenu des besoins, des structures administratives en vigueur, des disponibilités matérielles et humaines et des contraintes budgétaires, la commission a défini, de la manière suivante, la philosophie d'une rénovation possible à échéance immédiate. (a) Dans l'enseignement fondamental, tout enfant doit pratiquer l'activité physique à raison d'une séance quotidienne; il est parfaitement possible d'agir en sorte que les activités et les structures générales de l'école ne soient pas bouleversées. ..." ... [less ▲]

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See detailPure red cell aplasia following peripheral stem cell transplantation: complete response to a short course of high-dose recombinant human erythropoietin.
Martelli, M.; Ponchio, L.; Beguin, Yves ULg et al

in Haematologica (1994), 79(5), 456-9

We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia ... [more ▼]

We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia. Corticosteroid treatment was ineffective. Four months after transplantation rHuEpo was administered subcutaneously at a dose of 150 U/Kg per day, five days a week for 8 weeks. Treatment induced an erythropoietic response and corrected anemia. Response was maintained following discontinuation of rHuEpo. This study and previous reports indicate that high doses of rHuEpo given over a short time can resolve PRCA following autologous or allogeneic stem cell transplantation. [less ▲]

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See detailC'est le bouquet... Histoire d'un ornement typographique liégeois du XVIIIe siècle
Droixhe, Daniel ULg

in Gutenberg-Jahrbuch (1994), 69

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See detailPlasma Beta-Endorphin Response of Thoroughbred Horses to Maximal Exercise
Art, Tatiana ULg; Franchimont, P.; Lekeux, Pierre ULg

in Veterinary Record : Journal of the British Veterinary Association (1994), 135(21), 499-502

Ten horses underwent a standardised strenuous treadmill exercise test, before, during and after which measurements were made of plasma beta-endorphin and cortisol concentrations, blood lactate, glucose ... [more ▼]

Ten horses underwent a standardised strenuous treadmill exercise test, before, during and after which measurements were made of plasma beta-endorphin and cortisol concentrations, blood lactate, glucose, haemoglobin and pH, the activities of creatine kinase, lactate dehydrogenase and aspartate amino-transferase, and heart rate, oxygen uptake and expired minute volume. The correlations between the exercise-induced response of beta-endorphin and the changes observed in the other physiological measurements were examined. There was a large variation in the beta-endorphin response of the horses to exercise. The increase in beta-endorphin was correlated significantly and inversely with the treadmill velocity at which maximal oxygen uptake was reached. It was also significantly and directly correlated with the heart rate during recovery, the increase in plasma lactate concentration and the change in blood pH, indicating that the exercise-induced increase in beta-endorphin concentration was smaller in horses with a higher aerobic capacity [less ▲]

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See detailCauses de mortalité et teneur en métaux lourds de Guillemots de Troïl Uria aalge échoués le long du littoral belge.
Bouquegneau, Jean-Marie ULg; Debacker, Virginie ULg; Antoine, Nathalie et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 211-217

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See detailTraducteurs et traductions dans l'Egypte gréco-romaine
Rochette, Bruno ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1994), 69(138), 313-322

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See detailMechanism of Thiamine Transport in Neuroblastoma Cells. Inhibition of a High Affinity Carrier by Sodium Channel Activators and Dependence of Thiamine Uptake on Membrane Potential and Intracellular Atp
Bettendorff, Lucien ULg; Wins, Pierre

in Journal of Biological Chemistry (1994), 269(20), 14379-14385

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a ... [more ▼]

Nerve cells are particularly sensitive to thiamine deficiency. We studied thiamine transport in mouse neuroblastoma (Neuro 2a) cells. At low external concentration, [14C]thiamine was taken up through a saturable high affinity mechanism (Km = 35 nM). This was blocked by low concentrations of the Na+ channel activators veratridine (IC50 = 7 +/- 4 microM) and batrachotoxin (IC50 = 0.9 microM). These effects were not antagonized by tetrodotoxin and were also observed in cell lines devoid of Na+ channels, suggesting that these channels are not involved in the mechanism of inhibition. At high extracellular concentrations, thiamine uptake proceeds essentially via a low affinity carrier (Km = 0.8 mM), insensitive to veratridine but blocked by divalent cations. In both cases, the uptake was independent on external sodium, partially inhibited (10-35%) by depolarization and sensitive to metabolic inhibitors. A linear relationship between the rate of thiamine transport and intracellular ATP concentration was found. When cells grown in a medium of low thiamine concentration (6 nM) were exposed to 100 nM extracellular thiamine, a 3-fold increase in intracellular thiamine diphosphate was observed after 2 h while the concomitant increase in intracellular free thiamine was barely significant. These data suggest a secondary active transport of thiamine, the main driving force being thiamine phosphorylation rather than the sodium gradient. [less ▲]

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See detailEvaluation d’une expérience de rénovation de l’enseignement fondamental: Méthodologie de recherche
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine

in Revue de l'Education Physique (1994), 34(2-3), 117-120

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples ... [more ▼]

Un projet pédagogique de l'envergure de celui qui fut mis en place dans l'enseignement fondamental de la Communauté française de Belgique exige que l'on considère les effets possibles sous de multiples éclairages. Par les personnes auxquelles il s'adresse, par la diversité de ces effets et par l'organisation qu'il requiert, par la nécessité de mettre en évidence les relations de causalité, il a nécessité une méthodologie d'évaluation multidimensionnelle. ... [less ▲]

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See detailLATTICE-DYNAMICS AND DIELECTRIC-PROPERTIES OF INCIPIENT FERROELECTRIC TIO2 RUTILE
LEE, C.; Ghosez, Philippe ULg; GONZE, X.

in Physical Review. B : Condensed Matter (1994), 50(18), 13379-13387

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See detailMalignant Hyperthermia and Severe Hypoglycemia after Reexposure to Halothane
Bichel, T.; Canivet, Jean-Luc ULg; Damas, Pierre ULg et al

in Acta Anaesthesiologica Belgica (1994), 45(1), 23-7

A four year child presented with an episode of malignant hyperthermia induced by reexposure to halothane. The episode was associated with early onset of a severe hypoglycemia and liver enzymatic ... [more ▼]

A four year child presented with an episode of malignant hyperthermia induced by reexposure to halothane. The episode was associated with early onset of a severe hypoglycemia and liver enzymatic perturbances. Etiology of these perturbances is hard to state precisely in this clinical context, but a hepatic toxicity of halothane and/or by dantrolene is considered. [less ▲]

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See detailSynthesis and biodistribution of [5-131I]iodotropapride: a potential D2 dopamine receptor imaging agent.
Cantineau, Robert; Guillaume, Marcel; Damhaut, Philippe et al

in Nuclear Medicine & Biology (1994), 21(2), 255-62

[5-131I]Iodotropapride is a benzamidic compound which displays high affinity and selectivity for dopaminergic receptors. It was prepared from the corresponding brominated compound by a nucleophilic ... [more ▼]

[5-131I]Iodotropapride is a benzamidic compound which displays high affinity and selectivity for dopaminergic receptors. It was prepared from the corresponding brominated compound by a nucleophilic substitution with [131I]iodine (t1/2 = 8.02 days, E gamma = 364 keV) based on the use of Cu(I) as catalyst and high specific activity of [131I]NaI. After i.v. injection in rats the tracer crosses the blood-brain barrier (0.42 +/- 0.06% of injected dose in the total brain) and demonstrates a high affinity binding to the striatum. The striatum-to-cerebellum ratio increases with time and reaches values of 9 and 22 at 30 and 120 min after injection, respectively. This specific uptake in the striatum is saturable and can be blocked by pretreatment with different D2 antagonists. When labeled with 123I (t1/2 = 13 h, E1 = 159 keV), the corresponding [123I]iodotropapride may be useful for the investigation of the D2 dopamine receptors in humans with single photon emission computer tomography (SPECT). [less ▲]

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See detailCrystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme
Mande, S. C.; Mainfroid, V.; Kalk, K. H. et al

in Protein Science : A Publication of the Protein Society (1994), 3(5), 810-21

The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement ... [more ▼]

The crystal structure of recombinant human triosephosphate isomerase (hTIM) has been determined complexed with the transition-state analogue 2-phosphoglycolate at a resolution of 2.8 A. After refinement, the R-factor is 16.7% with good geometry. The asymmetric unit contains 1 complete dimer of 53,000 Da, with only 1 of the subunits binding the inhibitor. The so-called flexible loop, comprising residues 168-174, is in its "closed" conformation in the subunit that binds the inhibitor, and in the "open" conformation in the other subunit. The tips of the loop in these 2 conformations differ up to 7 A in position. The RMS difference between hTIM and the enzyme of Trypanosoma brucei, the causative agent of sleeping sickness, is 1.12 A for 487 C alpha positions with 53% sequence identity. Significant sequence differences between the human and parasite enzymes occur at about 13 A from the phosphate binding site. The chicken and human enzymes have an RMS difference of 0.69 A for 484 equivalent residues and about 90% sequence identity. Complementary mutations ensure a great similarity in the packing of side chains in the core of the beta-barrels of these 2 enzymes. Three point mutations in hTIM have been correlated with severe genetic disorders ranging from hemolytic disorder to neuromuscular impairment. Knowledge of the structure of the human enzyme provides insight into the probable effect of 2 of these mutations, Glu 104 to Asp and Phe 240 to Ile, on the enzyme. The third mutation reported to be responsible for a genetic disorder, Gly 122 to Arg, is however difficult to explain. This residue is far away from both catalytic centers in the dimer, as well as from the dimer interface, and seems unlikely to affect stability or activity. Inspection of the 3-dimensional structure of trypanosomal triosephosphate isomerase, which has a methionine at position 122, only increased the mystery of the effects of the Gly to Arg mutation in the human enzyme. [less ▲]

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See detailEnantioselective synthesis of 6-[fluorine-18]-fluoro-L-dopa from no-carrier-added fluorine-18-fluoride.
Lemaire, Christian ULg; Damhaut, Philippe; Plenevaux, Alain ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1994), 35(12), 1996-2002

METHODS: A trimethylammonium veratraldehyde triflate was synthesized and used as a precursor for the asymmetric synthesis of 6-[18F]fluoro-L-dopa. RESULTS: Its nucleophilic fluorination with 18F-fluoride ... [more ▼]

METHODS: A trimethylammonium veratraldehyde triflate was synthesized and used as a precursor for the asymmetric synthesis of 6-[18F]fluoro-L-dopa. RESULTS: Its nucleophilic fluorination with 18F-fluoride produced by the 18O(p,n)18F nuclear reaction on enriched 18O-water led to the corresponding no-carrier-added [18F]fluoroveratraldehyde (45 +/- 5% EOB). Diiodosilane was used to prepare the corresponding [18F]fluorobenzyl iodide (36.5 +/- 5.3% EOB). Akylation of (S)-1-tert-boc-2-tert-butyl-3-methyl-4-imidazolidinone with this electrophilic agent, hydrolysis and purification by preparative high-pressure liquid chromatography made 6-[18F]fluoro-L-dopa ready for human injection, in a 23% +/- 6% decay-corrected radiochemical yield. The enantiomeric purity and the specific activity were above 96% and 1 Ci/mumole respectively. CONCLUSION: Through this procedure, starting from 250 mCi of 18F-fluoride, multimillicurie amounts (32 +/- 8.5 mCi) of no-carrier-added 6-[18F]fluoro-L-dopa are now available at the end of synthesis (90 min) with a good radiochemical purity (more than 98%). [less ▲]

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See detailCaracteristiques des phosphatases acides de l'orge en condition de stress hydrique.
Ben-Naceur, M'B.; Paul, Roger ULg; Portetelle, Daniel ULg et al

in Cahiers Agricultures (1994), 3(4),

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See detailImprovement Of Enzymatic-Synthesis Yields Of Flavor Acetates - The Example Of The Isoamyl Acetate
Razafindralambo, Hary ULg; Blecker, Christophe ULg; Lognay, Georges ULg et al

in Biotechnology Letters (1994), 16(3), 247-250

Isoamyl acetate synthesis was chosen as a model to improve flavour acetate yields by optimising the enzymatic reaction. Alcohol:acid molar ratio, temperature, water content and amount of enzyme effects ... [more ▼]

Isoamyl acetate synthesis was chosen as a model to improve flavour acetate yields by optimising the enzymatic reaction. Alcohol:acid molar ratio, temperature, water content and amount of enzyme effects were analyzed. The optimum values were respectively 4, 45 degrees C, 0,1% (w/v) and 0,5 g. In these conditions, the synthesis yield reached 80% after 24 h of reaction and was found 15 times greater than those already reported in the literature. [less ▲]

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See detailDe l'école à l'entreprise ou le processus d esocialisation mis en échec
Robert, Jocelyne ULg

in Eucation-Formation (1994)

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See detailOpportunities for fine gold recovery from a copper flotation circuit using Knelson concentrator
Patchejieff, B.; Gaydardzhiev, Stoyan ULg; Lazarov, D.

in Minerals Engineering (1994), 7(2/3), 405-408

Experiments aimed at determination of the character of the gold observed in a copper ore processed by flotation, and also to evaluate the possibilities of improvement of the total gold recovery have been ... [more ▼]

Experiments aimed at determination of the character of the gold observed in a copper ore processed by flotation, and also to evaluate the possibilities of improvement of the total gold recovery have been carried out. The gravity equipment used was a 7.5" Knelson screen hydrostatic concentrator, reported of being capable of treatment and upgrading of up to 1000 times raw material with about 30% hypothetical concentration of heavy flotation sized particles. The gold-to-sulfides ratio obtained during the various runs was chosen as a general criterion for the type of gold presented (free or locked) and for the gravity approach feasibility. [less ▲]

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See detailMetalloproteinases and serine proteases activities in mixed spheroids of mouse B16 melanoma cells and fibroblasts
Coucke, Paul; Baramova, Eugenia; Leprince, Pierre ULg et al

in International Journal of Oncology (1994), 5

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See detailModulatory Effect of Neuropeptide Y on Acetylcholine-Induced Oedema and Vasoconstriction in Isolated Perfused Lungs of Rabbit
Delaunois, Annie ULg; Gustin, Pascal ULg; Dessy-Doize, C. et al

in British Journal of Pharmacology (1994), 113(3), 973-81

1. The modulatory role of neuropeptide Y (NPY) on pulmonary oedema induced by acetylcholine and capsaicin was investigated. The effects of NPY on the haemodynamic response to acetylcholine, phenylephrine ... [more ▼]

1. The modulatory role of neuropeptide Y (NPY) on pulmonary oedema induced by acetylcholine and capsaicin was investigated. The effects of NPY on the haemodynamic response to acetylcholine, phenylephrine and substance P were also investigated. 2. Isolated, ventilated, exsanguinated lungs of the rabbit were perfused with a constant flow of recirculating blood-free perfusate. The double/arterial/venous occlusion method was used to partition the total pressure gradient (delta Pt) into four components: the arterial gradient (delta Pa), the pre- and post-capillary gradients (respectively delta Pa' and delta Pv') and the venous pressure gradient (delta Pv). Endothelial permeability was evaluated by measuring the capillary filtration coefficient (Kf,c). 3. Acetylcholine (10(-8) M to 10(-4) M) and substance P (SP, 10(-10) M to 10(-6) M) induced a concentration-dependent increase in the Kf,c. Capsaicin (10(-4) M) and 5-hydroxytryptamine (5-HT) (10(-4) M) also increased this parameter. NPY (10(-8) M) completely inhibited the effects of acetylcholine and capsaicin on the Kf,c, without preventing the effects of substance P and 5-HT. 4. Acetylcholine induced concentration-dependent vasoconstriction in the precapillary segment. The effect was inhibited by NPY and aspirin, an inhibitor of cyclo-oxygenase, while ketanserin, a 5-HT2 receptor antagonist, and SR140333, a new NK1 antagonist, had no protective effect. Phenylephrine increased delta Pa at high concentration, an effect also inhibited by NPY and aspirin. Substance P had no significant haemodynamic effect. When injected together with NPY, substance P (10(-6) M) induced a significant increase in the total pressure gradient.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailPlasma IGF-I levels as predictive criteria of growth performances in cattle
Renaville, Robert ULg; Sneyers, Myriam; Massart, Serge et al

in Growth Regulation (1994), 4(suppl 1), 115

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See detailThe Compartmentation of Phosphorylated Thiamine Derivatives in Cultured Neuroblastoma Cells
Bettendorff, Lucien ULg

in Biochimica et Biophysica Acta (1994), 1222(1), 7-14

Thiamine transport in cultured neuroblastoma cells is mediated by a high-affinity carrier (KM = 40 nM). In contrast, the uptake of the more hydrophobic sulbutiamine (isobutyrylthiamine disulfide) is ... [more ▼]

Thiamine transport in cultured neuroblastoma cells is mediated by a high-affinity carrier (KM = 40 nM). In contrast, the uptake of the more hydrophobic sulbutiamine (isobutyrylthiamine disulfide) is unsaturable and its initial transport rate is 20-times faster than for thiamine. In the cytoplasm, sulbutiamine is rapidly hydrolyzed and reduced to free thiamine, the overall process resulting in a rapid and concentrative thiamine accumulation. Incorporation of radioactivity from [14C]thiamine or [14C]sulbutiamine into intracellular thiamine diphosphate is slow in both cases. Despite the fact that the diphosphate is probably the direct precursor for both thiamine monophosphate and triphosphate, the specific radioactivity increased much faster for the latter two compounds than for thiamine diphosphate. This suggests the existence of two pools of thiamine diphosphate, the larger one having a very slow turnover (about 17 h); a much smaller, rapidly turning over pool would be the precursor of thiamine mono- and triphosphate. The turnover time for thiamine triphosphate could be estimated to be 1-2 h. When preloading the cells with [14C]sulbutiamine was followed by a chase with the same concentration of the unlabeled compound, the specific radioactivities of thiamine and thiamine monophosphate decreased exponentially as expected, but labeling of the diphosphate continued to increase slowly. Specific radioactivity of thiamine triphosphate increased first, but after 30 min it began to slowly decrease. These results show for the first time the existence of distinct thiamine diphosphate pools in the same homogeneous cell population. They also suggest a complex compartmentation of thiamine metabolism. [less ▲]

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See detailAge-related differences in updating working memory
Van der Linden, Martial ULg; Brédart, Serge ULg; Beerten, A.

in British Journal of Psychology (1994), 85(1), 145-152

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See detailTypage moléculaire de Clostridium perfringers.
Daube, Georges ULg; Simon, P.; Limbourg, B. et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailELEMENT DIFFUSION IN THE SOLAR INTERIOR
Thoul, Anne ULg; BAHCALL, J. N.; LOEB, A.

in Astrophysical Journal (1994), 421(2), 828-842

We study the diffusion of helium and other heavy elements in the solar interior by solving exactly the set of flow equations developed by Burgers for a multicomponent fluid, including the residual heat ... [more ▼]

We study the diffusion of helium and other heavy elements in the solar interior by solving exactly the set of flow equations developed by Burgers for a multicomponent fluid, including the residual heat-flow terms. No approximation is made concerning the relative concentrations, and no restriction is placed on the number of elements considered. We give improved diffusion velocities for hydrogen, helium, oxygen, and iron, in the analytic form derived previously by Bahcall & Loeb. These expressions for the diffusion velocities are simple to program in stellar evolution codes and are expected to be accurate to similar to 15%. We find that the inclusion of the residual heat flow terms leads to an increase in the hydrogen diffusion velocity. We compare our numerical results-with those obtained analytically by Bahcall & Loeb using a simplified treatment, as well as with those derived numerically by Michaud & Proffitt. We find that for conditions characteristic of the Sun, the results of Bahcall & Loeb for the hydrogen diffusion velocity are smaller than our more accurate numerical results by similar to 30%, except very near the center where the error becomes larger. The Michaud & Proffitt results differ from the numerical results derived here by less than or similar to 15%. Our complete treatment of element diffusion can be directly incorporated in a standard stellar evolution code by means of an exportable subroutine, but, for convenience, we also give simple analytical fits to our numerical results. [less ▲]

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See detailMuscle Fibre Type and Size, and Muscle Capillary Density in Young Double-Muscled Blue Belgian Cattle
Stavaux, D.; Art, Tatiana ULg; Mc Entee, Kathleen ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1994), 41(3), 229-236

Bovine muscle biopsies were analysed for fiber type and capillary density by the acid ATP-ase and amylase-PAS methods respectively. Samples obtained from Belgian blue double muscled (DM) calves were ... [more ▼]

Bovine muscle biopsies were analysed for fiber type and capillary density by the acid ATP-ase and amylase-PAS methods respectively. Samples obtained from Belgian blue double muscled (DM) calves were compared for their fibre type, size and vascularization with samples from Friesian (F) calves. The animals were sampled both at 2 and 7 months of age. Changes in histochemical composition occurring with ageing, independently of the breed, and differences related to the muscle sampled by comparing biopsies obtained from the longissimus dorsi (LD) and gluteobiceps (GB) muscles in animals of both breed were also investigated. Independently of age and muscle, fibre type I percentage and area were significantly higher in F than in DM muscles. Type IIa area was significantly larger in F than in DM, while fibre type IIb percentage and area were higher in DM. The number of capillaries/mm2 was significantly higher in F than in DM. Fibre type IIa and IIb percentage as well as the diameter of the three fibre types was significantly higher in the oldest animals. Finally, independently of age and breed, fibre type I and IIb percentages were significantly higher in LD but lower in GB. The results mainly demonstrated that Belgian blue DM muscles present a higher proportion of IIb fibres and a lower capillary supply than F muscles. [less ▲]

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See detailGenetic diversity among some wild populations of lima bean (Phaseolus lunatus L.) proceeding from Central Valley of Costa Rica
Maquet, Alain; Wathelet, Bernard ULg; Dubois, Sophie et al

in Annual Report of the Bean Improvment Cooperative (1994)

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See detailTransient hypersensitivity to apomorphine-induced gnawing after termination of acute effects high dose of cocaine
Tirelli, Ezio ULg; Witkin, J. M.

in Behavioural Pharmacology (1994), 5(3), 289-298

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from ... [more ▼]

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from brain and the BEs of COC had dissipated (2 hrs and 4 hrs after administration), effects of AP on gnawing were increased 4-fold. This dopaminergic hypersensitivity (DA-H) was induced by acute treatment with doses of 15 mg/kg COC and higher. Effects of AP were not enhanced 6-24 hrs after COC, indicating a rapid waning of the DA-H. Hypersensitivity to AP (AP-H) was not further augmented by 8 days of daily COC injections. COC did not influence climbing and hypomotility induced by AP 4 hrs after its injection, demonstrating selectivity in the BEs of the DA-H. Further, COC did not induce sensitization to its own effects, indicating that the AP-H was not due to a typical sensitization phenomenon. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailChemically selected subclones of the CEM cell line demonstrate resistance to HIV-1 infection resulting from a selective loss of NF-kappa B DNA binding proteins.
Qian, J.; Bours, Vincent ULg; Manischewitz, J. et al

in Journal of Immunology (1994), 152(8), 4183-91

To delineate cellular genes that are required for optimal HIV-1 infection, CEM cells were subjected to treatment with the chemical mutagen ethylmethanesulfonate (EMS) and subclones were selected based on ... [more ▼]

To delineate cellular genes that are required for optimal HIV-1 infection, CEM cells were subjected to treatment with the chemical mutagen ethylmethanesulfonate (EMS) and subclones were selected based on their increased resistance to HIV-1 infection and reduced syncytium formation, despite relatively normal CD4 expression (20,000 to 25,000 receptors/cell). Two subclones with this phenotype demonstrated a diminished capacity of HIV-1 long terminal repeat-chloramphenicol acetyl transferase expression either after treatment with the protein kinase C activator PMA, or through Tat-mediated transactivation. In this study, we show that the cellular levels of the NF-kappa B DNA binding proteins (but not AP1 or SP1) are markedly reduced in these cell mutants both at the mRNA and protein levels, resulting in reduced nuclear localization of p50/p65 after PMA induction or treatment with the lymphokine TNF-alpha. Transient reconstitution with a plasmid expressing p50 resulted in partial recovery of PMA-inducible LTR-chloramphenicol acetyl transferase expression. These data suggest that, at least in the CEM T cell line, a selective reduction in the NF-kappa B DNA binding proteins is sufficient to curtail HIV-1 infection. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Bouwen met Staal (1994), n°117

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1994), 37

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair ... [more ▼]

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair haemodynamics in calves. Central venous, pulmonary arterial and capillary wedge and systemic arterial pressures were measured by fluid-filled catheters in 11 calves. Cardiac output was measured by the thermodilution technique, heart rate (HR) was derived from the ECG and stroke volume (SV), pulmonary and systemic vascular resistance were calculated. The haemodynamic values were measured hourly from the first to the tenth hour alter intratracheal inoculation of P. haemolytica. Cardiovascular response was marked and typically consisted of two hypotensive hypodynamic phases. The first, which occurred by the second hour after inoculation, consisted of a transient bradycardia and a systemic vasodilation leading to profound hypotension and reduced venous return. Cardiac performance then recovered, but systemic hypotension persisted and hypoxaemia developed. The second phase occurred by the seventh hour alter inoculation and was associated with a decline in SV, an increase in HR, and pulmonary hypertension. Three different degrees of cardiovascular dysfunctions were found, differing basically in the intensity of the first phase bradycardia and second phase reduction in SV and systemic arterial pressure, suggesting that experimental pneumonia produced by intratracheal instillation of P. haemolytica in calves results in distinct cardiovascular dysfunctions depending on the animal. Ignorance of the underlying haemodynamic status therefore precludes reliable interpretation of physiological as well as pharmacological results using this model of respiratory disease [less ▲]

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See detailMadin Darby Bovine Kidney Cell Synchronization by Lovastatin: Application to Bovine Herpesvirus-1 Gene Expression
Vanderplasschen, Alain ULg; Hanon, E.; Benarafa, C. et al

in Veterinary Research (1994), 25(6), 555-67

The number of investigations involving cell proliferation has increased rapidly in the last years. One of the major difficulties in studying cell-cycle-related events is obtaining highly synchronous cell ... [more ▼]

The number of investigations involving cell proliferation has increased rapidly in the last years. One of the major difficulties in studying cell-cycle-related events is obtaining highly synchronous cell populations without metabolic imbalance. This study demonstrates that the Madin Darby bovine kidney (MDBK) cells, a commonly used cell line in veterinary research, can be effectively synchronized using lovastatin (Lov), a drug used to treat hypercholesteremia in humans. This was demonstrated by the following results: (i) Lov inhibits cell proliferation in a dose-dependent manner; (ii) Lov synchronizes MDBK cells mainly in the G1 and secondarily in the G2+M cell-cycle phases; (iii) the cytostatic effect of Lov can be specifically inhibited by addition of mevalonate (Mev) (Lov inhibits the synthesis of Mev); (iv) removal of Lov from G1-arrested cultures, followed by addition of Mev, resulted in the synchronous recovery of DNA synthesis; and (v) 5-bromo2'-deoxyuridine incorporation experiments revealed that MDBK cells synchronization by Lov can be followed for at least 3 cycles after removal of Lov and addition of Mev. Furthermore, as an application of investigations based on the availability of synchronized MDBK, we showed that bovine herpesvirus-1 gene expression is independent on the cell cycle. [less ▲]

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See detailHuman RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.
Bours, Vincent ULg; Azarenko, V.; Dejardin, Emmanuel ULg et al

in Oncogene (1994), 9(6), 1699-702

RelB belongs to the family of Rel-related proteins, dimers of which determine NF-kappa B activity. The murine RelB protein has been reported to be a dimerizing partner in kappa B-binding complexes which ... [more ▼]

RelB belongs to the family of Rel-related proteins, dimers of which determine NF-kappa B activity. The murine RelB protein has been reported to be a dimerizing partner in kappa B-binding complexes which are capable of transactivation. On the other hand, the I-Rel protein, the presumed human homolog of RelB, was proposed to be an inhibitor whose presence in dimeric complexes interfered with their kappa B binding and therefore interfered also with transactivation. We demonstrate that human RelB (I-Rel) forms with p50 and p52 (p50B) kappa B-binding heterodimeric complexes which potently transactivate kappa B-dependent constructs in transfection studies. It is concluded that human RelB (I-Rel) and murine RelB can both function as transactivators and that no significant species-specific differences exist. [less ▲]

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See detailENANTIOSELECTIVE SYNTHESES OF NCA (S)-L-[BETA-C-11]-4-CHLOROPHENYLALANINE AND (S)-L-(ALPHA-METHYL)-[BETA-C-11]-4-CHLOROPHENYLALANINE
Plenevaux, Alain ULg; Al-Darwich, M. J.; Lemaire, Christian ULg et al

in Applied Radiation & Isotopes (1994), 45(3), 361-369

The radiolabeling of (S)-L-4-chlorophenylalanine and (S)-L-(alpha-methyl)-4-chlorophenylalanine were realized with carbon-11 at position beta through a radiochemical synthesis relying on the highly ... [more ▼]

The radiolabeling of (S)-L-4-chlorophenylalanine and (S)-L-(alpha-methyl)-4-chlorophenylalanine were realized with carbon-11 at position beta through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro[alpha-C-11]benzyl bromide and the lithium enolate of (S)-1-(t-butyloxycarbonyl)-2-(t-butyl)-3-methyl-1,3-imidazolidine-4-one for (S)-L-[beta-C-11]-4-chlorophenylalanine and of (2S,5S)-1-(t-butyloxycarbonyl)-2-(t-butyl)-3,5-dimethyl-1,3-imidazolidin e-4-one for (S)-L-(alpha-methyl)-[beta-C-11]-4-chlorophenylalanine. Quantities of about 25-35 mCi were obtained at the end of synthesis, ready for injection, after hydrolysis and HPLC purification with a radiochemical yield of 19% corrected to EOB within 45 min. The enantiomeric excesses were shown to be greater than or equal to 97% for both molecules without chiral separation. The radiochemical and the chemical purities of the final compounds were greater than or equal to 98% and the specific activity at the end of synthesis ranged between 250-800 mCi/mu mol. [less ▲]

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See detailLa responsabilité délictuelle des communes
Lewalle, Paul ULg; Dressen, Cécile; Durviaux, Ann-Lawrence ULg

in Revue de Droit Communal (1994)

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See detailComparison of Reproductive Performance in Belgian Dairy and Beef Cattle
Hanzen, Christian ULg; Laurent, Y.; Ward, W. R.

in Theriogenology (1994), 41(5), 1099-114

A computerized program was written to collect, evaluate and compare reproductive performance data of 2004 beef (Belgian Blue breed) and 1649 dairy (Friesian Holstein and German Red) cattle in 35 Belgian ... [more ▼]

A computerized program was written to collect, evaluate and compare reproductive performance data of 2004 beef (Belgian Blue breed) and 1649 dairy (Friesian Holstein and German Red) cattle in 35 Belgian herds (6 suckler beef herds, 9 milked beef herds and 20 dairy herds). Reproduction data were collected at monthly herd health visits. No difference in age at first calving was observed. Significant differences were observed among the 3 kinds of herds, and the best results were obtained in dairy herds for the calving interval, interval from calving to the first estrus, interval from calving to the first service and average number of days open. Concerning these parameters, first calvers had lower results than multiparous cows, mainly in suckler and milked beef herds. Significant differences were noted in the number of services per pregnancy. Heifers that had never calved presented the highest fertility. Primiparous beef cows had higher fertility than pluriparous cows. In dairy herds, pluriparous cows had higher fertility than primiparous cows. Estrus detection was better in milked beef herds than in suckled beef and dairy herds. Suckled beef herds had the lowest incidence of metritis and ovarian cysts of the three types of herds. Rates of abortion, overall culling and retained fetal membranes were similar in all the herds. The percentage of animals removed for infertility was highest in milked beef herds and lowest in dairy herds. Because 90% of the 1159 calvings recorded in the beef herds required a caesarean section, the reproductive performance of beef cattle represent results after caesarean section. [less ▲]

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See detailEtude épidémiologique de la toxoplasmose chez les femmes enceintes à Amiens (Picardie). Nécessité d'une enquête nationale
Carme, Bernard; Lenne, Evelyne; Tirard, Véronique et al

in Médecine et Maladies Infectieuses (1994), 24

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives ... [more ▼]

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives vis à vis de cette parasitose. Cette étude a permis de mettre en évidence la bonne connaissance des mesures préventives vis à vis de la toxoplasmose chez les femmes non immunes. Ceci a permis également de préciser les données épidémiologiques de la toxoplasmose à Amiens. Le choix d'un protocole incluant les femmes au moment de l'accouchement pourrait être complété par celui de femmes en début de grosesse pour éviter d'exclure les interruptions de grossesse. Cette étude devrait déboucher sur une enquête nationale qui permettrait de préciser l'épidémiolgoie de la toxoplasmose en France. [less ▲]

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See detailNote sous l'arrêt de la CJCE du 19 janvier 1994, Eurocontrol
Partsch, Philippe-Emmanuel ULg

in Journal des Tribunaux Droit Européen (1994)

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See detailWanze/Huccorgne: Station de l'Hermitage
Noiret, Pierre ULg

in Chronique de l'Archéologie wallonne (1994), 2

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See detailCinétique de récupération fonctionnelle de la ventilation pulmonaire après pontage aortocoronaire
Croisier, Jean-Louis ULg; Parisse, J.; Camus, G. et al

in Annales de Réadaptation et de Médecine Physique (1994), 37

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See detailCoupling and carbonylation of iodoaromatics and terminal alkynes or alkynols catalyzed by a dimeric palladium hydroxide
Delaude, Lionel ULg; Masdeu, Anna M.; Alper, Howard

in Synthesis (1994), (11), 1149-1151

The palladium(II) complex [(Ph(3)P)Pd(Ph)mu-OH)](2) is an effective catalyst for the coupling and carbonylation of alkynes and iodoarenes to give acetylenic ketones in 63-94% yields. Acetylenic hydroxy ... [more ▼]

The palladium(II) complex [(Ph(3)P)Pd(Ph)mu-OH)](2) is an effective catalyst for the coupling and carbonylation of alkynes and iodoarenes to give acetylenic ketones in 63-94% yields. Acetylenic hydroxy ketones were formed using secondary or tertiary alkynols as reactants. [less ▲]

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See detailA recombinant viral haemorrhagic septicaemia virus glycoprotein expressed in insect cells induces protective immunity in rainbow trout
Lecocq-Xhonneux, F.; Thiry, M.; Dheur, I. et al

in Journal of General Virology (The) (1994), 75

Viral haemorrhagic septicaemia (VHS) is a fish rhabdovirus infection of world-wide importance. Control policies have been established but the disease still causes heavy losses in fish farming. The ... [more ▼]

Viral haemorrhagic septicaemia (VHS) is a fish rhabdovirus infection of world-wide importance. Control policies have been established but the disease still causes heavy losses in fish farming. The development of a recombinant subunit vaccine was initiated to produce a safe and effective vaccine to protect fish against VHS. The VHS virus (VHSV) glycoprotein, which induces neutralizing antibodies in rainbow trout, was chosen for expression in insect cells using a baculovirus vector. The Mr of the recombinant protein estimated by SDS-PAGE was slightly lower than that of the native viral protein. The recombinant protein displayed different degrees of glycosylation and was recognized in ELISA by neutralizing antibodies. It was transported to the plasma membrane of insect cells where its ability to induce membrane fusion was preserved. The efficacy of the recombinant protein as a vaccine was compared with those of an inactivated and an attenuated vaccine. When injected intraperitoneally into rainbow trout, the baculo-virus-encoded protein was shown (i) to induce the synthesis of VHSV-neutralizing antibodies and (ii) to confer protection against virus challenge. Immunization performed by immersion failed. This is the first report of a recombinant vaccine that protects fish against VHSV. [less ▲]

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See detailGeometric control of a pyridoxal-catalyzed aldol condensation
Koh, John T.; Delaude, Lionel ULg; Breslow, Ronald

in Journal of the American Chemical Society (1994), 116(25), 11234-11240

A chiral cyclophane derivative of pyridoxal has been synthesized that has amino groups oriented specifically over one face of the cofactor. The compound catalyzes the formation of threonine and allo ... [more ▼]

A chiral cyclophane derivative of pyridoxal has been synthesized that has amino groups oriented specifically over one face of the cofactor. The compound catalyzes the formation of threonine and allo-threonine from glycine and acetaldehyde with enantioinductions that are a function of pH, reversing the optical selectivity between low pH and high pH. The stereochemical results are compared with those of structurally related pyridoxal cyclophanes that lack titratable catalytic groups. Explanations are advanced for this stereochemical reversal and for the otherwise surprising preference of most of these compounds to react on the more hindered face of the pyridoxal. Models indicate that the transamination intermediate is distorted by the transannular chain, and stereoelectronic arguments predict that this distortion should lead to reaction on the face that carries the chain, as observed. The stereochemical reversal with the attached (dimethylamino)alkyl group, as a function of pH, may reflect catalysis by the protonated form, but metal coordination by the basic form cannot be excluded. [less ▲]

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See detailDynamique du carbone inorganique des eaux de surface dans l'embouchure de l'Escaut
Frankignoulle, Michel; Biondo, Renzo ULg; Bouquegneau, Jean-Marie ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 61

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See detailInteractions between the biofilm growth and the hydrodynamics in an aerobic trickling filter
Lekhlif, B.; Toye, Dominique ULg; Marchot, Pierre ULg et al

in Water Science & Technology (1994), 29

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See detailDo canine scalene and sternomastoid muscles play a role in breathing?
De Troyer, A.; Cappello, M.; Brichant, Jean-François ULg

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1994), 76(1), 242-52

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on ... [more ▼]

To assess the respiratory function of the scalene and sternomastoid muscles in the dog, we studied the effect of graded increases in inspiratory airflow resistance and single-breath airway occlusion on the electrical activity of these muscles in 18 supine anesthetized spontaneously breathing animals. The sternomastoids never showed any activity, and the scalenes showed some inspiratory activity during occlusion in only two animals. The adoption of the prone position and bilateral cervical vagotomy did not affect this pattern. Hypercapnia also did not elicit any sternomastoid activity and induced scalene inspiratory activity during occlusion in only four of nine animals. On microscopic examination, however, both muscles were found to contain large numbers of spindles, suggesting that they have the capacity to respond to stretch. In addition, with increases in inspiratory resistance, both the sternum and ribs were displaced in the caudal direction. As a result, the scalenes demonstrated a gradual inspiratory lengthening and the normal inspiratory lengthening of the sternomastoids was accentuated. Additional studies in three unanesthetized animals showed consistent activity in the scalene and sternomastoid muscles during movements of the trunk and neck but no activity during breathing, including occluded breathing. These observations thus indicate that the alpha-motoneurons of the scalene and sternomastoid muscles in the dog have very small central respiratory drive potentials with respect to their critical firing threshold. In this animal, these muscles do not have a significant respiratory function. [less ▲]

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See detailInsulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.
Peers, Bernard ULg; Sharma, S.; Teitelman, G. et al

in Molecular Endocrinology (1994), 8(12), 1798-806

The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin ... [more ▼]

The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-expressing cells. The mechanism by which these peptide hormone genes are induced and then either maintained or repressed during development is unknown, but their coexpression in early precursor cells suggests the involvement of common regulatory factors. Here we show that the somatostatin transcription factor STF-1 is also a principal regulator of insulin expression in beta-cells of the pancreas. STF-1 stimulates the insulin gene by recognizing two well defined islet-specifying elements on the insulin promoter and by subsequently synergizing in trans with the juxtaposed helix-loop-helix protein E47. Within the STF-1 protein, an N-terminal trans-activation domain functions cooperatively with E47 to stimulate insulin transcription. As truncated STF-1 polypeptides lacking the N-terminal activation domain strongly inhibit insulin promoter activity in beta-islet cells, our results suggest that the specification of islet cell types during development may be in part determined by the expression of STF-1 relative to other islet cell factors. [less ▲]

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See detailTraitement de données par le logiciel Minitab
Claustriaux, Jean-Jacques ULg; Delvaux, A.

in Notes de Statistique et d'Informatique (1994), 1

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See detailVibration amplitudes caused by parametric excitation of cable stayed structures
Lilien, Jean-Louis ULg; Pinto da Costa, Antonio

in Journal of Sound & Vibration (1994), 174(N°1), 69-90

This paper deals with one kind of cable vibrations : the ones caused by parametric excitation.

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See detailModular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM
Kishan, Radha; Zeelen, Ph. Johan; Noble, Martin E.M. et al

in Protein Engineering (1994), 7(8), 945-51

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha ... [more ▼]

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha-unit of E. coli TIM with the equivalent unit of chicken TIM. This replacement involves 10 sequence changes. One of the changes concerns the mutation of a buried alanine (Ala232 in strand 8) into a phenylalanine. The ETIM8CHI structure shows that the A232F sequence change can be incorporated by a side-chain rotation of Phe224 (in helix 7). No cavities or strained dihedrals are observed in ETIM8CHI in the region near position 232, which is in agreement with the observation that ETIM8CHI and E.coli TIM have similar stabilities. The largest CA (C-alpha atom) movements, approximately 3 A, are seen for the C-terminal end of helix 8 (associated with the outward rotation of Phe224) and for the residues in the loop after helix 1 (associated with sequence changes in helix 8). From the structure it is not clear why the kcat of ETIM8CHI is 10 times lower than in wild type E.coli TIM. [less ▲]

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See detailTrickle flow in packed columns : new experimental and theoretical investigations
Crine, Michel ULg; Marchot, Pierre ULg; Toye, Dominique ULg et al

in Trends in Chemical Engineering (1994), 2

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See detailEvaluation de la chimiorésistance de Plasmodium falciparum. Revue des tests in vitro: méthodologie, intérêts et limites
Hayette, Marie-Pierre ULg; Carme, Bernard

in Publications Médicales Africaines (1994), 129

The chloroquine-resistance of Plasmodium falciparum appeared first in Southeast Asia and South-America during the sixties. It reached further the african continent in 1977, through Kenya and Tanzania. In ... [more ▼]

The chloroquine-resistance of Plasmodium falciparum appeared first in Southeast Asia and South-America during the sixties. It reached further the african continent in 1977, through Kenya and Tanzania. In Africa, the front of the resistance spread from East to West, and now completely covers Black Africa with different degrees of resistance. Rapidly, "in vivo" and "in vitro" tests were developped to assess the sensitivity of P. falciparum strains against the different antimalarial drugs. This paper is a review of existing "in vitro" and "in vivo" tests with their interest and limits. [less ▲]

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See detailSECULAR EVOLUTION OF THE VERTICAL COLUMN ABUNDANCES OF CHCLF2 (HCFC-22) IN THE EARTH'S ATMOSPHERE INFERRED FROM GROUND-BASED IR SOLAR OBSERVATIONS AT THE JUNGFRAUJOCH AND AT KITT-PEAK, AND COMPARISON WITH MODEL-CALCULATIONS
Zander, Rodolphe ULg; Mahieu, Emmanuel ULg; Demoulin, Philippe ULg et al

in Journal of Atmospheric Chemistry (1994), 18(2), 129-148

Series of high-resolution infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, between 06/1986 and 11/1992, and at Kitt Peak National Observatory ... [more ▼]

Series of high-resolution infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, between 06/1986 and 11/1992, and at Kitt Peak National Observatory, Tucson, Arizona (U.S.A.), from 12/1980 to 04/1992, have been analyzed to provide a comprehensive ensemble of vertical column abundances of CHClF2 (HCFC-22; Freon-22) above the European and the North American continents. The columns were derived from nonlinear least-squares curve fittings between synthetic spectra and the observations containing the unresolved 2nu6 Q-branch absorption of CHClF2 at 829.05 cm-1. The changes versus time observed in these columns were modeled assuming both an exponential and a linear increase with time. The exponential rates of increase at one-sigma uncertainties were found equal to (7.0 +/- 0.35)%/yr for the Junfraujoch data and (7.0 +/- 0.23)%/yr for the Kitt Peak data. The exponential trend of 7.0%/yr found at both stations widely separated in location can be considered as representative of the global increase of the CHClF2 burden in the Earth's atmosphere during the period 1980 to 1992. When assuming two realistic vertical volume mixing ratio profiles for CHClF2 in the troposphere, one quasi constant and the other decreasing by about 13% from the ground to the tropopause, the concentrations for mid-1990 were found to lie between 97 and 111 pptv (parts per trillion by volume) at the 3.58 km altitude of the Jungfraujoch and between .97 and 103 pptv at Kitt Peak, 2.09 km above sea level. Corresponding values derived from calculations using a high vertical resolution-2D model and recently compiled HCFC-22 releases to the atmosphere, were equal to 107 and 105 pptv, respectively, in excellent agreement with the measurements. The model calculated lifetime of CHClF2 was found equal to 15.6 years. The present results are compared critically with similar data found in the literature. On average, the concentrations found here are lower by 15-20% than those derived from in situ investigations; this difference cannot be explained by the absolute uncertainty of +/- 11% assigned presently to the infrared remote measurements. [less ▲]

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See detailR. Sacré, « Les Negro Spirituals et les Gospel Songs »
Pirenne, Christophe ULg

in Cahiers de Clio (1994), 119

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See detailLe contrôle de l'infection par le virus de la rhinotrachéite infectieuse bovine
Lemaire, Mylène; Pastoret, Paul-Pierre ULg; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailTaqI restriction fragment length polymorphism for bovine growth hormone in bovine breeds selected for milk and/or meat
Renaville, Robert ULg; Sneyers, Myriam; Falaki, Mohammed et al

in Journal of Animal Science (1994), 72(suppl 1), 316

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See detailIncidence des aménagements hydrauliques sur le contrôle du développement de la bilharziose (shistosomiase)
Pliez, A.; Moens, R.; Debouche, Charles ULg

in Annales de Gembloux (1994), (100), 53-65

Le développement des irrigations dans les zones tropicales et subtropicales du monde, pour augmenter les productions de nourriture, a provoqué la prolifération de maladies liées à l'eau comme la ... [more ▼]

Le développement des irrigations dans les zones tropicales et subtropicales du monde, pour augmenter les productions de nourriture, a provoqué la prolifération de maladies liées à l'eau comme la bilharziose (également appelée shistosomiase), la dengue, la filariose et l'onchocercose. [less ▲]

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See detailStereoelectronic properties of five anti-HSV-1 2′-deoxynucleosides analogues with heterocyclic substituents in the 5-position: A comparison with BVDU
Olivier, Anne; Creuven, Isabelle; Evrard, Christine ULg et al

in Antiviral Research (1994), 24

Structural and electronic characteristics of 5-(5-chlorothien-2-yl)-2′-deoxyuridine (I), 5-(furan-2-yl)-2′-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2′-deoxyuridine (III), 5-(3-bromoisoxazol-5-yl)-2′ ... [more ▼]

Structural and electronic characteristics of 5-(5-chlorothien-2-yl)-2′-deoxyuridine (I), 5-(furan-2-yl)-2′-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2′-deoxyuridine (III), 5-(3-bromoisoxazol-5-yl)-2′-deoxyuridine (V) and 5-(isoxazol-5-yl)-2′-deoxyuridine (IV) have been determined and compared to the BVDU (VI) characteristics in order to explain their respective affinity for the herpes simplex virus type 1 thymidine kinase (TK). Molecular structure of 5-(5-chlorothien-2-yl)-2′-deoxyuridine has been obtained using single crystal X-ray crystallography. Electrostatic potential maps, energy and topology of frontier orbitals were computed at the ab initio MO STO-3G and STO-3G* level. These studies reveal that the electrostatic potential energy maps are clearly dependent on the affinity of the compound for the enzyme. [less ▲]

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See detailFood Consumption in Belgium
Reginster-Haneuse, G.; Gosset, Christiane ULg

in Bibliotheca Nutritio et Dieta (1994), (51), 108-12

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See detailSWIMMING PUPPY SYNDROME IN A LITTER OF BOUVIER-DES-FLANDRES
Poncelet, Luc; Gilbert, S.; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1994), 138(2), 121-123

This paper describes the clinical, serologic, electrophysiologic and pathologic findings in three Bouvier des Flandres puppies exhibiting the swiming puppy syndrome. The puppies had no antibodies against ... [more ▼]

This paper describes the clinical, serologic, electrophysiologic and pathologic findings in three Bouvier des Flandres puppies exhibiting the swiming puppy syndrome. The puppies had no antibodies against distemper virus, T. gondii and N. caninum. A myopathy was suspected because spontaneous activities were disclosed in all muscle groups and muscles enzymes were elevated. However the pathologic findings were unable to confirm this hypothesis. [less ▲]

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See detailRound Table Conference on Mediators of Sepsis--Brussels, Belgium, March 21-23, 1992
Lamy, Maurice ULg; Thijs, L. G.

in Intensive Care Medicine (1994), 20(3), 238-41

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See detailPolitical Aesthetics: Cross-Cultural Desire and the Capitulation of Form in the Work of Kazuo Ishiguro and Salman Rushdie
Delrez, Marc ULg

in BELL. Belgian Essays on Language and Literature (1994)

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See detailBilateral diaphragmatic paralysis in a pony
Amory, Hélène ULg; Lomba, Fernand; Lekeux, Pierre ULg et al

in Journal of the American Veterinary Medical Association [=JAVMA] (1994), 205(4), 587-591

An adult pony had a 1-month history of severe respiratory distress that was resistant to treatment and environmental changes. Results of blood gas analysis were indicative of alveolar hypoventilation ... [more ▼]

An adult pony had a 1-month history of severe respiratory distress that was resistant to treatment and environmental changes. Results of blood gas analysis were indicative of alveolar hypoventilation. Simultaneous recordings of thoracic and abdominal wall motion by inductance plethysmography, together with complete pulmonary mechanics evaluation that included transdiaphragmatic pressure monitoring, revealed complete passive behavior of the diaphragm during breathing. Because radiography, necropsy, and histologic examination did not reveal any major lesion to explain the clinical and functional observations, bilateral diaphragmatic paralysis was diagnosed [less ▲]

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See detailControl of drug-resistant epilepsy after head injury with intravenous nimodipine.
HANS, Pol ULg; Triffaux, M.; BONHOMME, Vincent ULg et al

in Acta Anaesthesiologica Belgica (1994), 45(4), 175-8

The present report describes a young child who developed generalized epileptic seizures in the course of severe head injury. The start of epileptic seizures was associated with the occurrence of acute ... [more ▼]

The present report describes a young child who developed generalized epileptic seizures in the course of severe head injury. The start of epileptic seizures was associated with the occurrence of acute hyponatremia and hypoosmolality due to excessive Desmopressine administration. The seizures resistant to conventional therapy resolved completely with intravenous nimodipine infusion. [less ▲]

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See detailInvolvement Of The Cyclic Amp-Responsive Element-Binding Protein In Bovine Leukemia-Virus Expression In-Vivo
Adam, E.; Kerkhofs, P.; Mammerickx, M. et al

in Journal of Virology (1994), 68(9),

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See detailLa métropolisation, une nouvelle donne
Merenne-Schoumaker, Bernadette ULg

in Acta Geographica Lovaniensia (1994), (34), 165-174

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has ... [more ▼]

The recent economic growth of many big cities has led to the new concept of "metropolization" and to numerous research based on new models of urban growth. In trying to draw up on this theme, one has tackled successively four points: the concepts of metropolis and metropolization, the metropolization process, the metropolization and the city systems, the metropolization in Europe and Belgium. [less ▲]

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See detailLa Formation de Pepinster dans le Synclinorium de Verviers, entre Perpinster et Eupen (Belgique)-Contexte structural et stratigraphique
Dejonghe, L; Steemans, Philippe ULg

in Annales de la Société Géologique de Belgique (1994), 117

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See detailGender and diagnostic performance of the growth hormone response to clonidine for major depression : A large scale multicenter study
Schittecatte, Michel; Charles, Gerard; Machowski, R. et al

in American Journal of Psychiatry (The) (1994)

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See detailAnevrysme femoral superficiel rompu dans le cadre d'une neurofibromatose. A propos d'un cas
Van Damme, Hendrik ULg; Deprez, Manuel ULg; De Leval, Laurence ULg et al

in Journal des Maladies Vasculaires (1994), 19(1), 62-5

The authors observed the spontaneous rupture of a dysplastic superficial femoral artery in a 47 years old patient with Von Recklinghausen disease. The patient presents a gigantism of his right lower limb ... [more ▼]

The authors observed the spontaneous rupture of a dysplastic superficial femoral artery in a 47 years old patient with Von Recklinghausen disease. The patient presents a gigantism of his right lower limb. On angiography, the femoropopliteal axis is polyaneurysmal and there is evidence of rupture at mid-thigh. The diseased artery is excluded by interposition of a dacron prosthesis, with reimplantation of the deep femoral artery. Histology shows fibrohyalin thickening of the intima. Dysplasia of large limb arteries is excessively rare in Von Recklinghausen disease. [less ▲]

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See detailCARAIB - A global model of terrestrial biological productivity
Warnant, Pierre ULg; François, Louis ULg; Strivay, David ULg et al

in Global Biogeochemical Cycles (1994), 8(3), 255-270

CARAIB, a mechanistic model of carbon assimilation in the biosphere estimates the net primary productivity (NPP) of the continental vegetation on a grid of 1 degrees x 1 degrees in latitude and longitude ... [more ▼]

CARAIB, a mechanistic model of carbon assimilation in the biosphere estimates the net primary productivity (NPP) of the continental vegetation on a grid of 1 degrees x 1 degrees in latitude and longitude. The model considers the annual and diurnal cycles. It is based on the coupling of the three following submodels; a leaf assimilation model including estimates of stomatal conductance and leaf respiration, a canopy model describing principally the radiative transfer through the foliage, and a wood respiration model. Present-day climate and vegetation characteristics allow the discrimination between ecotypes. In particular, specific information on vegetation distribution and properties is successfully used at four levels; the leaf physiological level, the plant level, the ecosystem level, and the global level. The productivity determined by the CARAIB model is compared with local measurements and empirical estimates showing a good agreement with a global value of 65 Gt C yr(-1). The sensitivity of the model to the diurnal cycle and to the abundance of C-4 species is also tested. The productivity slightly decreases (10%) when the diurnal cycle of the temperature is neglected. By contrast, neglecting the diurnal cycle of solar irradiance produces unrealistically high values of NPP. Even if the importance of this increase would presumably be reduced by the coupling of CARAIB with a nutrient cycle model, this test emphasizes the key role of the diurnal cycle in a mechanistic model of the NPP. Uncertainties on the abundance and spatial distribution of C-4 plants may cause errors in the NPP estimates, however, as demonstrated by two sensitivity tests, these errors are certainly lower than 10% at the global scale as shown by two tests. [less ▲]

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See detailEvolution of shoot density of the Posidonia seagrass bed of Calvi Bay (Corsica)
Soullard, Mady; Bourge, Isabelle; Fogel, Julie et al

in Vie et Milieu (1994), 44

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See detailLe projet d'entreprise d'insertion: son impact en termes budgétaires et d'emplois
Defourny, Jacques ULg; Lequet, Nathalie; Tilkin, Michel

in Reflets et Perspectives de la Vie Economique (1994), XXIII(1-2), 157-171

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See detailFunctional Sites Of The Bovine Leukemia-Virus Envelope Glycoproteins Using Structural And Immunological Data
Callebaut, I.; Mornon, Jp.; Burny, A. et al

in Archives Internationales de Physiologie de Biochimie et de Biophysique (1994), 102(2),

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See detailImmunological detection of beta-galactosidase-expressing cells by flow cytometry
Vanderplasschen, Alain ULg; Goltz, M.; Hanon, E.

in Biochemica (1994), 3

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