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See detailDéveloppement du tissu adipeux chez le porc
Claes, Victor; Chaput, Mariella; Nicolas, Nathalie et al

in Agricontact (1995), 279

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See detailTrente cinq années de programmes d'histoire dans l'enseignement secondaire francophone
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1995), 45e année(n°3), 1-6

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See detailMeasuring productive performance in the non-life insurance industry: the case of French and Belgian markets
Fecher-Bourgeois, Fabienne ULg; Pestieau, Pierre ULg; Perelman, Sergio ULg et al

in Tijdschrift voor Economie en Management (1995), (40), 47-69

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See detailGrowth hormone-binding protein (GHBP) binds prolactine in cattle plasma
Massart, Serge; Ban, Anna-Maria; Renaville, Robert ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995), 103

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See detailRecherche expérimentale sur le comportement au feu des colonnes en béton armé
Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg; Baus, Raymond et al

in Annales de l'Institut Technique du Bâtiment et des Travaux Publics [=AIBTP] (1995), 539(254), 25-41

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See detailVaricella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency
Debrus, Serge; Sadzot-Delvaux, Catherine ULg; Nikkels, Arjen ULg et al

in Journal of Virology (1995), 69(5), 3240-3245

Varicella-zoster virus (VZV) gene 63 encodes a protein with a predicted molecular mass of 30.5 kDa which has amino acid similarities with the immediate-early (IE) protein 22 (ICP-22) of herpes simplex ... [more ▼]

Varicella-zoster virus (VZV) gene 63 encodes a protein with a predicted molecular mass of 30.5 kDa which has amino acid similarities with the immediate-early (IE) protein 22 (ICP-22) of herpes simplex virus type 1. In order to study the expression of this protein during lytic and latent infection, gene 63 was cloned in frame and downstream from the glutathione-S-transferase gene, expressed as a fusion protein, and purified. In VZV-infected Vero cells, antibodies directed against this protein detect two polypeptides of 45 and 38 kDa which are localized both in the cytoplasm and in the nucleus. Using a sequential combination of transcription and protein synthesis inhibitors (actinomycin D and cycloheximide, respectively), we demonstrated the immediate-early nature of this protein, which can thus be named IE63. Using a rat model of VZV latency, we showed that IE63 is heavily expressed, essentially in neurons, during latency. IE63 can also be detected in the skin of patients showing early herpes zoster symptoms. [less ▲]

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See detailFinite-amplitude regimes of the short-wave Marangoni-Benard convective instability.
Colinet, Pierre; Legros, Jean-Claude; Kamotani, Y. et al

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 52(3), 2603-2616

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See detailFear reactions of domestic sheep confronted with either a human or a human-like model
Bouissou, Marie-France; Vandenheede, Marc ULg

in Behavioural Processes (1995), 34

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See detailActivation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro.
Sheridan, P. L.; Sheline, C. T.; Cannon, K. et al

in Genes & Development (1995), 9(17), 2090-104

Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha (TCR alpha) enhancer in a context-restricted manner in T cells. In ... [more ▼]

Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha (TCR alpha) enhancer in a context-restricted manner in T cells. In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 (HIV-1) enhancer, which contains DNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by LEF-1. First, we show that mutations in the LEF-1-binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells, and that LEF-1/GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. Second, recombinant LEF-1 is shown to activate HIV-1 transcription on chromatin-assembled DNA in vitro. By using a nucleosome-assembly system derived from Drosophila embryos, we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and Ets-1) supplemented with fractions containing the promoter-binding protein, Sp1. Addition of TFE-3, which binds to an E-box motif upstream of the LEF-1 and Ets-1 sites, further augments transcription in this system. Individually or collectively, none of the three enhancer-binding proteins (LEF-1, Ets-1, and TFE-3) could activate transcription in the absence of Sp1. A truncation mutant of LEF-1 (HMG-88), which contains the HMG box but lacks the trans-activation domain, did not activate transcription from nucleosomal DNA, indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. We conclude that transcription activation by LEF-1 in vitro is a chromatin-dependent process that requires a functional trans-activation domain in addition to the HMG domain. [less ▲]

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See detail3-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine
Dupont, l; Liégeois, Jean-François ULg; Rogister, F. et al

in Acta Crystallographica Section C-Crystal Structure Communications (1995), C51

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See detailOpera Latina : la banque de données de textes latins du L.A.S.L.A. sur CD-ROM
Purnelle, Gérald ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1995)

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See detailUtilisation des biopesticides pour la protection de pommes en conservation.
Jijakli, Mohamed ULg; Lepoivre, Philippe ULg

in Fruit Belge (1995), 63(455), 83-88

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See detailDebate. Personal Experience and Research Experience : A Reflexive Account
Martiniello, Marco ULg; Ouali, Nouria; Choenni, C.

in Merger (1995), 3(2), 4-7

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See detailEfficacité des solutions envisagées par des enseignants en formation face à des problèmes rencontrés dans des leçons d’éducation physique
Beckers-Ledent, Maryse; Cloes, Marc ULg; Delfosse, Catherine et al

in Revue de l'Education Physique (1995), 35(4), 173-179

La recherche sur l'efficacité de l'enseignement s'est concrétisée et a trouvé application dans plusieurs ouvrages de didactique. Elle a été menée à partir de données directement observables, les ... [more ▼]

La recherche sur l'efficacité de l'enseignement s'est concrétisée et a trouvé application dans plusieurs ouvrages de didactique. Elle a été menée à partir de données directement observables, les comportements et stratégies d'enseignement dans l'action en classe. L'observation des comportements des enseignants, des élèves et des interactions entre ces différents acteurs a contribué à identifier des variables du processus en relation positive ou négative avec les progrès des élèves. ... [less ▲]

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See detailFemoral bone density and vitamin D deficiency in elderly women
DEROISY; Pirenne, H; Frederick, I et al

in Archives of Public Health (1995), 52(S1), 81

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See detailDepistage des neoplasies endocriniennes multiples de type 1 (NEM 1). Reflexion du Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1).
Cougard, P.; Calender, A.; Carnaille, B. et al

in Annales de Chirurgie (1995), 49(6), 500-506

The "Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1 ... [more ▼]

The "Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1). The objectives of this group are to define diagnostic and therapeutic protocols and to carry out genetic research on NEM1. The first aim of physicians is to recognize the syndrome and to determine the appropriate screening especially into two circumstances: 1 degree In case of isolated and sporadic glandular disease -i-e-parathyroid glands, endocrine pancreas, antehypophysis, adrenal glands and neuroendocrine tumors? 2 degrees In case of very high probability of NEM 1 syndrome? This paper answers these two questions, based on the analysis of the first 150 cases collected by the GENEM 1. [less ▲]

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See detailPerformance of Belgian hospitals: a frontier approach
Fecher-Bourgeois, Fabienne ULg; Bosmans, Nathalie

in Health Economics (1995), 4,5(Sep-oct 1995), 389-397

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See detailFoie et maladies inflammatoires du tube digestif
Belaiche, Jacques ULg; Houbiers, G.; Louis, Edouard ULg

in Médecine et Hygiène (1995), 53

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See detailEnergy levels of High l - States in Neutral and Singly Ionized Argon
Palmeri, P.; Biémont, Emile ULg

in Physica Scripta (1995), 51

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See detailModified glucagon test allowing simultaneous estimation of insulin secretion and insulin sensitivity: application to obesity, insulin-dependent diabetes mellitus, and noninsulin-dependent diabetes mellitus.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Journal of Clinical Endocrinology and Metabolism (1995), 80(2), 393-9

The aim of this study was to describe an adaptation of the glucagon test allowing the simultaneous characterization of insulin secretion and sensitivity. A glucagon test (1 mg/m2) was performed in healthy ... [more ▼]

The aim of this study was to describe an adaptation of the glucagon test allowing the simultaneous characterization of insulin secretion and sensitivity. A glucagon test (1 mg/m2) was performed in healthy subjects (n = 11), obese patients (n = 5), insulin-dependent diabetics (n = 9), nonobese noninsulin-dependent diabetics (n = 7), and overweight noninsulin-dependent diabetics (n = 8). Previously, they had been connected to the Biostator, modified for continuous blood collection. Endogenous insulin secretion induced by glucagon was derived from integrated C-peptide concentrations. An index of insulin sensitivity was obtained by dividing the rate of decrease in blood glucose by the total amount of insulin entering the circulation (secreted+infused by the Biostator). The indices of insulin sensitivity obtained in the above groups of subjects were, respectively, 0.064 +/- 0.006, 0.030 +/- 0.006, 0.037 +/- 0.007, 0.021 +/- 0.006, and 0.016 +/- 0.002 mmol/L.U.min (P < 0.001). The estimated insulin secretion values in the 20 min following glucagon injection were, respectively, 0.38 +/- 0.05, 0.65 +/- 0.08, 0.05 +/- 0.01, 0.26 +/- 0.15, and 0.30 +/- 0.07 U (P < 0.001). The insulin sensitivity index obtained from this test correlated with the glucose MCR obtained from a euglycemic glucose clamp (r = 0.816; P < 0.001; n = 12). C-Peptide levels after glucagon administration were also significantly correlated with the estimated endogenous insulin secretion (r = 0.808; P < 0.001; n = 30). This adaptation of the classical glucagon test is an efficient and simple method to simultaneously evaluate insulin secretion and insulin sensitivity. [less ▲]

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See detailShort administration of metformin improves insulin sensitivity in android obese subjects with impaired glucose tolerance.
Scheen, André ULg; Letiexhe, Michel ULg; Lefebvre, Pierre ULg

in Diabetic Medicine : A Journal of the British Diabetic Association (1995), 12(11), 985-9

In a double-blind, randomized, cross-over study, the metabolic effects of a short treatment with metformin (2 x 850 mg day-1 for 2 days and 850 mg 1 h before evaluation) were compared to those of placebo ... [more ▼]

In a double-blind, randomized, cross-over study, the metabolic effects of a short treatment with metformin (2 x 850 mg day-1 for 2 days and 850 mg 1 h before evaluation) were compared to those of placebo in 15 obese subjects (BMI: 33.2 +/- 0.9 kg m-2), with abdominal distribution of adipose tissue and impaired glucose tolerance. An intravenous glucose tolerance test (0.3 g glucose kg-1) was performed after each period of treatment. Areas under the curve (AUC0-180 min) were calculated for plasma glucose, insulin, and C-peptide levels. Glucose tolerance was estimated by the coefficient of glucose assimilation (KG). Insulin sensitivity (SI) and glucose effectiveness (SG) indices were calculated using Bergman's minimal model. Insulin secretion rate (ISR) was determined by deconvolution of plasma C-peptide levels and insulin metabolic clearance rate (MCR) was estimated by dividing AUC 1SR by AUC insulin. Fasting plasma insulin levels were reduced after metformin (89.3 +/- 15.9 vs 112.4 +/- 24.3 pmol l-1; p = 0.04). AUC glucose, KG and SG were similar in both tests. However, AUC insulin was reduced (39.7 +/- 6.5 vs 51.8 +/- 10.4 nmol min l-1; p = 0.02), while SI (6.98 +/- 1.14 vs 4.61 +/- 0.42 10(-5) min-1 pmol-1 l; p = 0.03) and insulin MCR (715 +/- 116 vs 617 +/- 94 ml min-1 m-2; p = 0.03) were increased after metformin. The demonstration that metformin rapidly improves insulin sensitivity should encourage further research to evaluate the long-term effects of metformin in android obese subjects with impaired oral glucose tolerance. [less ▲]

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See detailExploration biologique actuelle du métabolisme du fer
Charlier, Corinne ULg; Plomteux, Guy ULg

in Revue de la Médecine Générale (1995), 123

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See detailneuroendocrinology in the perinatal period
Battisti, Oreste ULg

in mini acta of belgian society of pediatrics (1995), 27

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See detail3,7-Dimethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide zwitterion
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailBanques de donnees sur les pesticides et l'environnement: outils precieux pour l'information et la promotion d'un usage correct des pesticides.
Schiffers, Bruno ULg; Cooper, J. F.; Copin, A. et al

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30(4), 319-338

La Convention de Lomé contient un certain nombre de dispositions traitant directement des pesticides, de la lutte intégrée (IPM), de l'environnement et du développement. L'article 40 spécifie que la ... [more ▼]

La Convention de Lomé contient un certain nombre de dispositions traitant directement des pesticides, de la lutte intégrée (IPM), de l'environnement et du développement. L'article 40 spécifie que la Communauté européenne devra fournir toutes les informations disponibles sur les pesticides en vue d'aider les États ACT à promouvoir un usage correct et sans risques de ceux-ci. Le problème le plus immédiat est le manque d'information. [less ▲]

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See detailStatistical and Non-statistical Reactions in Energy Selected Fluoromethane Ions.
Weitzel, K.-M.; Güthe, F.; Mähnert, J. et al

in Chemical Physics (1995), 201

The unimolécular reactions of the fluoromethane ion have been investigated by the threshold photoelectron photoion coincidence technique (TPIPECO). The breakdown curves have been measured in the energy ... [more ▼]

The unimolécular reactions of the fluoromethane ion have been investigated by the threshold photoelectron photoion coincidence technique (TPIPECO). The breakdown curves have been measured in the energy range between the adiabatic ionization potential of 12.53 eV and 21 eV. In this enery range the formation of the CH2F+, CHF+, CH2+, CH3+, and CF+ fragment ions is observed. The appearance energies (AE) for these ions at 300K are 13.2, 13.91, 13.93, 14.51 and <17.7 eV respectively. The 0K threshold energy for the formation of CH2F+ ions is 13.37 eV. Two different pathways for the unimolecular reaction of the fluoromethane ion can be distinguished.The reaction proceeding through the electronic ground state of the ion is entirely statistical. In contrast to this the reaction occurring through the first electronic excited state shows non-statistical behaviour. The two pathways are distinguished via the kinetic energy released in the respective dissociation channels. While all thermodynamically allowed reaction channels are observed on the ion ground state potential, the first excited state seems to decay predominantly by F loss reaction. [less ▲]

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See detailPrediction Of The Antigenic Sites Of The Cystic-Fibrosis Transmembrane Conductance Regulator Protein By Molecular Modeling
Gallet, X.; Benhabiles, N.; Lewin, M. et al

in Protein Engineering (1995), 8(8), 829-34

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and ... [more ▼]

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and valuable antibodies have been raised [Muller et al. (1990) J. Gen. Virol., 71, 2709-2717]. We have improved the modelling approach to allow us to predict epitopes from the primary sequences of the cystic fibrosis transmembrane conductance regulator. The procedure involves searching for fragments of primary sequences likely to make amphipathic secondary structures, which are hydrophilic enough to be at the surface of the folded protein and thus accessible to antibodies. Amphipathic helices were predicted using the methods of Berzofsky, Eisenberg and Jahnig. Their hydrophobic-hydrophilic interface was calculated and drawn, and used to predict the orientation of the helices at the surface of the native protein. Amino acids involved in turns were selected using the algorithm of Eisenberg. Tertiary structures were calculated using 'FOLDING', a software developed by R. Brasseur for the prediction of small protein structures [Brasseur (1995) J. Mol. Graphics, in press]. We selected sequences that folded as turns with at least five protruding polar residues. One important property of antibodies is selectivity. To optimize the selectivity of the raised antibodies, each sequence was screened for similarity (FASTA) to the protein sequence from several databanks. Ubiquitous sequences were discarded. This approach led to the identification of 13 potential epitopes in the cystic fibrosis transmembrane conductance regulator: seven helices and six loops. [less ▲]

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See detailFormer par les stages
Jadoulle, Jean-Louis ULg

in Pédagogies. Cahiers du Laboratoire de Pédagogie Expérimentale de l'Université de Louvain (1995), X

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See detailApplication of sucrose synthase from rice grains for the synthesis of carbohydrates.
Elling, Lothar; Grothus, Marita; Zervosen, Astrid ULg et al

in Annals of the New York Academy of Sciences (1995), 750

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are ... [more ▼]

The enzymatic synthesis of oligosaccharides offers an efficient way to obtain regiospecific and stereo-selective natural and nonnatural target molecules. However, the very expensive activated sugars are required as substrates for glycosyltransferases. Activated sugars are usually synthesized by pyrophosphorylases from nucleoside triphosphates and sugar-l-phosphates.'.* For cyclic in situ regeneration, at least three enzymes are needed, which makes the synthesis of, for example, N-acetyllactosamine very complex by established procedure. We report here on the enzymatic synthesis of saccharides and activated sugars by the plant glycosyltransferase sucrose synthase (EC 2.4.1.13)! The glycosyltransferase has the unique feature of catalyzing in vitro the synthesis and cleavage of sucrose (SCHEME1 ). The main advantage of sucrose synthase over pyrophosphorylases is the utilization of nucleoside diphosphates (NDP) instead of nucleoside triphosphates to generate activated sugars. [less ▲]

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See detailParticle fluxes over a Mediterranean seagrass bed: a one-year sediment trap experiment
Dauby, Patrick ULg; Bale, A. J.; Bloomer, N. et al

in Marine Ecology. Progress Series (1995), 126

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See detail'Overlapping Territories, Intertwined Histories': Cross-Culturality in Caryl Phillips's Crossing the River
Ledent, Bénédicte ULg

in Journal of Commonwealth Literature (1995), 30(1), 55-62

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See detailInteresting Lines in the Infrared Solar Spectrum. II. Unblended Lines between 1.0 and 1.8µm
Ramsauer, J.; Solanki, S. K.; Biémont, Emile ULg

in Astronomy and Astrophysics. Supplement Series (1995), 113

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See detailSurface Molecular Structure of Self-Assembled Alkanethiols Evidenced by UPS, Synchrotron Radiation and HREELS
Duwez, Anne-Sophie ULg; Riga, Joseph; ghijsen, Jacques et al

in Journal of Electron Spectroscopy & Related Phenomena (1995), 76

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See detailRegime et tactique alimentaires de la loutre (Lutra lutra) en France: synthèse.
Libois, Roland ULg

in Cahiers d'Ethologie (1995), 15(2-3-4), 251-274

More than 1500 otter spraint samples have been collected in different aquatic habitats throughout the present geographic range of the otter in France. Prey remains were identified, the relative occurrence ... [more ▼]

More than 1500 otter spraint samples have been collected in different aquatic habitats throughout the present geographic range of the otter in France. Prey remains were identified, the relative occurrence and abundance of each species was assessed and the biomass of each individual prey estimated. When available, data about the fish communities (size frequency- distributions, relative abundance) were compared with the diet of the mustelid. The main conclusions of the study are as follows: 1. The otter is mainly piscivorous but some other aquatic (crayfish) or semiaquatic preys (frogs, Natrix-snakes, some birds and mammals) are of major dietary importance in oligotrophic habitats. 2. The composition of the diet is determined by the local fish resources. The otter is an opportunistic predator, its diet varying greatly from one place to another. The diet can also change depending upon the season or upon some special circumstances such as frog or fish reproduction or strong prey-community changes. 3. Small fish are dominant in the diet. No size selection has been evidenced at least in the eel and in the cyprinid fishes. As far as the trout is concerned, it seems that the otter consumes preferably medium sized individuals. 4. The proportion of some prey species is lower in the diet than in the habitat. These are the more pelagic (bleak, sander, breams), rheophilic (dace, chub) or group-living species (minnow, roach). Bottom- (bullhead, eel, tench, gudgeon, barbel) or plant-living (rudd, pike) species are more frequent. [less ▲]

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See detailAnomalous pion decay in effective QCD at finite temperature
Blaschke, David; Jaminon, Martine ULg; Kalinovsky, Yu. L. et al

in Nuclear Physics A (1995), 592

The width of the process π0 → γγ is calculated within effective QCD at finite temperature. We use two different effective models which describe chiral symmetry breaking and its restoration at finite ... [more ▼]

The width of the process π0 → γγ is calculated within effective QCD at finite temperature. We use two different effective models which describe chiral symmetry breaking and its restoration at finite temperature in SU(2)ƒ: (i) an effective lagrangian with a nonlocal separable interaction kernel, (ii) A- and B-scaledNJL lagrangians which implement the scale anomaly of QCD. We calculate the temperature dependences of the quark and pion masses as well as of the pion-park-antiquark coupling strength below and above the double quark mass threshold. At zero temperature we obtain a fairly good agreement with the experimental value for the decay width. The temperature dependence of the decay width is related to that of the pion mass. Γπ0 → γγ is enhanced in the vicinity of the Mott temperature (Mπ = 2mq) for the nonlocal as well as for the A-scaled model and suppressed for the B-scaled model. We compare our results with the SU(2) Nambu-Jona-Lasinio model which is contained as a limiting case in our approach. [less ▲]

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See detailProposition Of A 3-Dimensional Representation Of The Constitutive Protein Of The Hepatitis-B Surface-Antigen Particles
Sonveaux, N.; Ruysschaert, Jm.; Brasseur, Robert ULg

in Journal of Protein Chemistry (1995), 14(6), 477-86

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle ... [more ▼]

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle membrane could provide helpful information for replacing surface-exposed protein domains by foreign sequences without destabilizing the particle structure. Since the crystallization of the protein in its lipid environment remains inaccessible in the near future, alternative approaches had to be envisaged. We combine here the available experimental structural and topological data with a conformational procedure to identify membrane-associated domains of the HBsAg protein and to propose a three-dimensional description of their assembly within the particle membrane. The proposed protein structure is composed of four membrane-spanning helices and an amphipatic helix located on the inner surface membrane. The transmembrane helices are assembled into a highly hydrophobic complex in which no access to the water environment is allowed. The approach could be extended to other membrane-associated proteins. [less ▲]

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See detailR-HuEPO hyporesponsiveness - who and why ?
Danielson, B.; Beguin, Yves ULg; Bommer, J. et al

in Nephrology Dialysis Transplantation (1995), 10

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See detail3-Methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailMolecular biology in support of an old paradigm about the induction of flowering
Périlleux, Claire ULg

in Flowering Newsletter (1995), 20

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See detailLa thermographie infrarouge dans l'étude de la thermorégulation : revue de la littérature
Spruyt, P.; Ghafir, Y.; Art, Tatiana ULg et al

in Annales de Médecine Vétérinaire (1995), 139

Infrared thermography is a method to assess the skin temperature by means of a camera equipped with an infrared detector. It makes thermograms that represents the surface temperature of skin patterns ... [more ▼]

Infrared thermography is a method to assess the skin temperature by means of a camera equipped with an infrared detector. It makes thermograms that represents the surface temperature of skin patterns. This article summerizes the different information about thermography and thermoregulation of horses. In fact, lots of information exist about thermoregulation of most of the domestic animais but very little exists as far as horses are concerned. Two different types of devices are used for thermography : contacting and noncontacting which measure the infrared radiation either with a thermometer or with a themographic camera. The blood circulation dictates the thermic model which is at the origin of thermographic interpretation. This latter is a good method helping to study thermoregulation. [less ▲]

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See detailApport des données RSO de ERS1 dans l’étude bathymétrique et pour la cartographie des zones intertidales
Cornet, Yves ULg; Ozer, André ULg; Ferrari, M.

in Documents de travail du Centre National de Recherches Géomorphologiques (1995), 30

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See detailRéalisation d'un appareillage mesure de l'anisotropie magnétique et application aux supraconducteurs à haute température critique
Vanderbemden, Philippe ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1995), 12

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See detailSurgical Technique for Reinforcement Cardiomyoplasty
RADERMECKER, Marc ULg; Chachques, J.C.; Fourny, J. et al

in Acta Chirurgica Belgica (1995), 95(6), 271-4

The current technique for reinforcement cardiomyoplasty in man is detailed. The authors emphasize the critical points that determine the perfect execution of this operation. This innovative surgical ... [more ▼]

The current technique for reinforcement cardiomyoplasty in man is detailed. The authors emphasize the critical points that determine the perfect execution of this operation. This innovative surgical approach to heart failure is continuously evolving and, therefore, may be subject to improvement. The major principles however remain valuable. [less ▲]

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See detailComment j'explore ... une anemie (2eme partie).
Beguin, Yves ULg

in Revue Médicale de Liège (1995), 50(11), 487-8

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See detailViability of cloned bovine embryos after one or two cycles of nuclear transfer and in vitro culture
Ectors, Fabien ULg; Delval, Alain; Smith, Lawrence et al

in Theriogenology (1995), 44

We described an exclusively in vitro procedure for cloning and recloning bovine embryos. Embryos obtained by IVM/IVF/IVC developed to the morula stage were used as blastomere donors in cunjunction with ... [more ▼]

We described an exclusively in vitro procedure for cloning and recloning bovine embryos. Embryos obtained by IVM/IVF/IVC developed to the morula stage were used as blastomere donors in cunjunction with IVM recipient oocytes. Reconstructed embryos were developed in vitro in co-culture using bovine oviductal epithelial cells. The resulting morulae were used as donors for recloning under the same experimental conditions. No significant difference was observed between cloning and recloning in terms of development (rates of blastocysts: 12.9 versus 14.9%), in the number of nuclei per blastocyst (63.8 versus 49.1), or in pregnancy rates (35.7 versus 33.3%). The high variability observed between replicates and the correlation between results in first and second cycle nuclear transfer may suggest an inherant potential of individual donor embryos to support development by cloning [less ▲]

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See detailCeci est mon corps
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5),

This is a special issue on the body in literature and art.

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See detailBases biologiques du comportement suicidaire: approche neuroendocrinienne et psychophysiologique du role des catecholamines.
Pitchot, William ULg; Hansenne, Michel ULg; Gonzalez Moreno, Antonio et al

in Acta Psychiatrica Belgica (1995), 95(4-5), 210-33

The current main neurochemical theories of the biological correlates of suicidal behavior principally involve the serotonergic system. Few data are available about the possible role of the ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior principally involve the serotonergic system. Few data are available about the possible role of the catecholaminergic (noradrenergic and dopaminergic) function. In the present study, in a first part, we assessed the growth hormone (GH) response to clonidine, a selective alpha 2-adrenergic agonist, and to apomorphine, a dopaminergic agonist, in 22 DSM-III-R major depressive male inpatients with a history of suicide attempts compared to 22 age-matched major depressive inpatients without history of suicidal behavior. Hormonal responses to clonidine and apomorphine were also compared with 4.00 PM postdexamethasone cortisol levels. The two groups differed significantly in the GH peak response after apomorphine: 6.27 +/- 3.18 ng/ml in suicide attempters vs 17.40 +/- 14.87 ng/ml in nonattempters (F = 11.78, p = 0.001). There was no statistically significant difference between the two groups for GH peak responses after clonidine. Moreover, mean postdexamethasone cortisol levels did not exhibit any significant difference between suicide attempters and nonattempters. Violent and nonviolent attempters did not differ on any of the biological measures. In a second part, P300 and contingent negative variation (CNV) were recorded in 20 depressive inpatients subgrouped into suicide attempters (n = 10) and nonattempters (n = 10). The results showed a significant reduction of both P300 and CNV amplitudes in patients who attempted suicide compared to patients without history of suicide attempts. Moreover, a significant correlation was found between the Suicidal Risk scale and CNV amplitude. In conclusion, these results suggest that a dopaminergic hypoactivity as assessed by a blunted GH response to apomorphine and by a reduction of both P300 and CNV amplitudes, could be considered as a biological correlate of suicidal behavior. In contrast, noradrenergic disturbances, particularly at the level of alpha 2-adrenergic receptors, seem to play a more minor role. Moreover, DST nonsuppression cannot be considered as a biological marker of suicidal behavior. [less ▲]

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See detailEconomic Geography
Merenne-Schoumaker, Bernadette ULg; Vlassenbroeck, Walter

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1995), 1995(2), 101-106

Identification and classification of 180 publications published in economic themes of geography in Belgium from 1984 to 1995

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See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

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See detailAcetic acid esters synthesis catalysed by Candida antarctica lipase.
Fonteyn, Fabienne ULg; Lognay, Georges ULg; Marlier, M.

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30(3), 183-188

Synthesis of various acetates catalysed by the Candida antarctica SP435 lipase was carried out in n-heptane. Reactions progress was established over a one hour period. Differences appeared in function of ... [more ▼]

Synthesis of various acetates catalysed by the Candida antarctica SP435 lipase was carried out in n-heptane. Reactions progress was established over a one hour period. Differences appeared in function of the structure and the chain length of alcohols: linalool and menthol were not esterified whereas the esterification of 1-dodecanol gave the highest rate (474 micromole per min and per g) and yield (86 per cent). [less ▲]

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See detailRectovaginal septum, endometriosis or adenomyosis: laparoscopic management in a series of 231 patients.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise et al

in Human Reproduction (1995), 10(3), 630-5

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases ... [more ▼]

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases. In three cases, the bowel lumen was entered. No other peri-operative complications were observed. Three cases of urinary retention were reported. The nodule resection resulted in considerable pain relief. Histologically, the rectovaginal nodule was similar to an adenomyoma. Indeed it was a circumscribed nodular aggregate of smooth muscle and endometrial glands. This form of disease must be considered as a specific disease which originates from the Mullerian rests present in the rectovaginal septum and we suggest that it be called 'rectovaginal adenomyosis'. [less ▲]

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See detailAcquis de la recherche en matière d'évaluation génétique des ovins et des caprins en Tunisie
D'Jemali, M'naouer; Jamal, Sofiene; Ben-Dhiaf, Sonia et al

in Cahiers Options Méditerranéennes (1995), 11

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 ... [more ▼]

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 flocks of Barbary sheep in 1987-92 are presented in 14 tables and discussed. [less ▲]

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See detailComparative double-blind multicenter study of the efficacy of tiludronate and etidronate in Paget's disease of bone
Roux, C; Gennari, C; Farrerons, J et al

in BONE (1995), 16(S1), 503

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See detailAn Atypical Anion Transporter Functioning at Acid pH in Neuroblastoma Cells
Bettendorff, Lucien ULg; Margineanu, Ilca; Wins, Pierre et al

in Biochemical and Biophysical Research Communications (1995), 207(1), 375-381

At pH 7.4, 36Cl- uptake by neuroblastoma cells was Na(+)-independent, saturable and blocked by submicromolar concentrations of DIDS. This suggests that at this pH, Cl- transport is mediated by an ... [more ▼]

At pH 7.4, 36Cl- uptake by neuroblastoma cells was Na(+)-independent, saturable and blocked by submicromolar concentrations of DIDS. This suggests that at this pH, Cl- transport is mediated by an exchanger analogous to erythroid band 3. At pH 6. [less ▲]

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See detailMémoire et imagerie mentale
Van der Linden, Martial ULg; Coyette, Françoise; Meulemans, Thierry ULg

in Questions de Logopédie (1995), 31

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See detailAttitude of a Young Surgeon toward Experimental Surgery. Roles and Limits of Experimental Surgery
Defraigne, Jean-Olivier ULg

in Acta Chirurgica Belgica (1995), 95(2, Mar-Apr), 113-7

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is ... [more ▼]

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is through research that surgeons can keep some critical mind, essential in their daily activities. However, too often actually, the surgeons abandon research. Two essential reasons explain the phenomenon: on the one hand, the weight of the clinical tasks and on the other hand the complexity of research founded on more and more specialized basic notions. In fact, the part of a surgical investigator must be to form a link between basic research and clinical activities. As such, work in collaboration with motivated basic investigators is cardinal. Also, the success of research depends upon the will of the departments to maintain a research activity, but it meets often with the difficulty in obtaining sufficient research credits. Finally, research can play an essential part in the education of the trainees and partly fill some gaps in their clinical training. [less ▲]

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See detailUse of shelter by grazing bulls: effect of climatic factors
Vandenheede, Marc ULg; Nicks, Baudouin ULg; Sheri, R. et al

in Animal Science (1995), 60

The time spent under a shelter by eight grazing fattening bulls of the Belgian Blue breed in each of 3 years consecutively for a total of 48 days was recorded using a time-lapse recorder with infrared ... [more ▼]

The time spent under a shelter by eight grazing fattening bulls of the Belgian Blue breed in each of 3 years consecutively for a total of 48 days was recorded using a time-lapse recorder with infrared illumination. During one grazing period, data were collected over 35 days (experiment 1). Observations were divided into 166 h with rain (20%) and 674 h without precipitation (80%). The average occupation rates were 15.4 (s.e. 29.1)% for the hours with rain and 4.5 (s.e. 14.8)% for the hours without precipitation (P < 0.001). The effect of intensity and duration of rain on the occupation rate was significant from 0.4 l/m(2) or from 2 h. Experiment 2 (13 days of observation) examined the influence of temperature and solar radiation on the use of shelter. The occupation rates were 21 (s.e. 23)% during the daylight hours (07.00 to 19.00 h), 6 (s.e. 8)% during the night (19.00 to 07.00 h) and 14 (s.e. 14)% during a 24-h period. The occupation rate between 07.00 and 19.00 h was significantly correlated to the mean daily temperature (r = 0.75), the maximum daily temperature (r = 0.86) and the direct solar radiation time (r = 0.60). When the maximum daily temperature exceeded 20 degrees C, the use of the shelter increased from 10 to 49% of the daylight hours. There was no significant difference between the live-weight gains of animals from the observed group and those of other bulls on an adjacent pasture without shelter. Nevertheless, these observations suggest that a shelter may improve the welfare of grazing cattle. [less ▲]

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See detailSimulating The Folding Of Small Proteins By Use Of The Local Minimum Energy And The Free Solvation Energy Yields Native-Like Structures
Brasseur, Robert ULg

in Journal of Molecular Graphics (1995), 13(5), 312-22

Assuming that the protein primary sequence contains all information required to fold a protein into its native tertiary structure, we propose a new computational approach to protein folding by ... [more ▼]

Assuming that the protein primary sequence contains all information required to fold a protein into its native tertiary structure, we propose a new computational approach to protein folding by distributing the total energy of the macromolecular system along the torsional axes. We further derive a new semiempirical equation to calculate the total energy of a macromolecular system including its free energy of solvation. The energy of solvation makes an important contribution to the stability of biological structures. The segregation of hydrophilic and hydrophobic domains is essential for the formation of micelles, lipid bilayers, and biological membranes, and it is also important for protein folding. The free energy of solvation consists of two components: one derived from interactions between the atoms of the protein, and the second resulting from interactions between the protein and the solvent. The latter component is expressed as a function of the fractional area of protein atoms accessible to the solvent. The protein-folding procedure described in this article consists of two successive steps: a theoretical transition from an ideal alpha helix to an ideal beta sheet is first imposed on the protein conformation, in order to calculate an initial secondary structure. The most stable secondary structure is built from a combination of the lowest energy structures calculated for each amino acid during this transition. An angular molecular dynamics step is then applied to this secondary structure. In this computational step, the total energy of the system consisting of the sum of the torsional energy, the van der Waals energy, the electrostatic energy, and the solvation energy is minimized. This process yields 3-D structures of minimal total energy that are considered to be the most probable native-like structures for the protein. This method therefore requires no prior hypothesis about either the secondary or the tertiary structure of the protein and restricts the input of data to its sequence. The validity of the results is tested by comparing the crystalline and computed structures of four proteins, i.e., the avian and bovine pancreatic polypeptide (36 residues each), uteroglobin (70 residues), and the calcium-binding protein (75 residues); the C alpha-C alpha maps show significant homologies and the position of secondary structure domains; that of the alpha helices is particularly close. [less ▲]

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See detailTreatment of Clostridium difficile colitis. Summary of a round table held in Brussels on March, 3rd, 1994.
Delmée, Michel; Melin, Pierrette ULg; Peetermans, Willy et al

in Acta Clinica Belgica (1995), 50(2), 114-6

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea ... [more ▼]

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea with metronidazole while maintaining the use of oral vancomycin in serious or life-threatening colitis. Clostridium difficile is a common cause of diarrhoea after antibiotic therapy and induces a spectrum of diseases ranging from mild diarrhoea to pseudomembranous colitis (PMC). It is considered to be the first cause of diarrhoea occurring among hospitalized patients (1). [less ▲]

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See detail2,4,7-Trimethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazinium 1,1-dioxide iodide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailContribution de la chimie macromoléculaire à l'élaboration de matériaux colloïdaux et microparticulaires destinés à la vectorisation de médicaments
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Innovation et Technologies en Biologie et en Médecine (1995), 16

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological ... [more ▼]

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological target. The aim of the paper is to give some insight about the contribution of the macromolecular engineering for the development of two vectors : microparticles of a control biodegradation rate designed for the chemoembolization of hepatocarcinoma , amphiphile copolymeric micelles able to transport drug within the targeted cells. Starting from a synthetic polymer : polylactide, degradation rate caracteristics , and functionalities can be tailored for the intended applications. One of the major problems , and largely underestimated in the past , for the successfull design of polymeric carrier is to take into account the interaction of proteins with polymer surfaces. [less ▲]

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See detailNimesulide
Dupont, L.; Pirotte, Bernard ULg; Masereel, B. et al

in Acta Crystallographica (1995), C51

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See detailDeux chansons relatives à des imprimeries liégeoises du XVIIIe siècle
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1995), 268

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See detailArt (de l'affiche) et pouvoir
Duchesne, Jean-Patrick ULg

in Art&Fact (1995), 14

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See detailSixièmes Journées scientifiques de Télédétection : télédétection des espaces urbains et péri-urbains
Donnay, Jean-Paul ULg

in Lettre d'information du Réseau de Télédétection de l'UREF (1995), 28

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See detailCabergoline in prolactinomen.
Abs, R.; Verhaert, G.; Demez, Pierre ULg et al

in Tijdschrift voor Geneeskunde (1995), 51

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See detailAmibiase intestinale sévère d'origine européenne?
Carme, Bernard; Viot, J.; Hayette, Marie-Pierre ULg et al

in Médecine et Maladies Infectieuses (1995), 25(5),

A case of severe amebic colitis in a 21 year-old french patient is described. It raises the problems of modality and place of contamination, Entamoeba histolytica levels of virulence and differenciation ... [more ▼]

A case of severe amebic colitis in a 21 year-old french patient is described. It raises the problems of modality and place of contamination, Entamoeba histolytica levels of virulence and differenciation between E. histolytica and E. dispar. [less ▲]

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See detailAssessment of lipoxygenase activity in seed extracts from 35 plant species
Fauconnier, Marie-Laure ULg; Vanzeveren, E.; Marlier, Michel et al

in Grasas y Aceites (1995), 46(1), 6-10

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several ... [more ▼]

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several species of Vigna (V. unguiculata, V. radiata and V. mungo) and one of Trifolium exhibit stronger lipoxygenase activity than soybean enzyme extracts. The pH-activity relationship was also established for 4 very active samples. GCMS analysis revealed equal amounts of 9- and 13 hydroperoxides of linoleic acid In these seed extracts, indicating no enzyme positional specificity. [less ▲]

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See detailL'articulation des réglementations en matière de crédit hypothécaire
Biquet, Christine ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1995), Dossier n° 2

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See detailRecent advances in ring-opening polymerization of lactones and related compounds
Lögfren, Anders; Albertsson, Ann-Christine; Dubois, Philippe ULg et al

in Journal of Macromolecular Science - Reviews in Macromolecular Chemistry and Physics (1995), C35(3), 379-418

Polyesters are currently synthesized by a step-growth mechanism from a mixture of a diol and a diacid (or a diacid derivative), or from a hydroxy-acid when available. Ring-opening polymerization (ROP) of ... [more ▼]

Polyesters are currently synthesized by a step-growth mechanism from a mixture of a diol and a diacid (or a diacid derivative), or from a hydroxy-acid when available. Ring-opening polymerization (ROP) of lactones and related compounds is an alternative method for the synthesis of aliphatic polyesters. Comparison of these two mechanisms is clearly in favor of the polyaddition process. The drawbacks of polycondensation are well known:high temperatures and long reaction times are required to produce high-molecular-weight chains. Even though conversion of the hydroxyl and acid group is close to completion, any departure from the reaction stoichiometry has a very detrimental effect on the chain length. [less ▲]

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See detailIncreased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel disease.
Louis, Edouard ULg; Louis, Renaud ULg; Drion, V. et al

in Allergy (1995), 50(9), 729-33

Although bronchopulmonary manifestations are rare in inflammatory bowel disease (IBD), subclinical abnormalities have been described in up to 50% of cases. The pathophysiology of these abnormalities ... [more ▼]

Although bronchopulmonary manifestations are rare in inflammatory bowel disease (IBD), subclinical abnormalities have been described in up to 50% of cases. The pathophysiology of these abnormalities remains unknown. However, a latent inflammation of the bronchial mucosa secondary to the inflammation of the intestinal mucosa has been suggested. This subclinical inflammation may lead to increased bronchial responsiveness. We studied the bronchial responsiveness in 38 inflammatory bowel disease (IBD) patients, using the methacholine test. Bronchial hyperresponsiveness was defined by a PC20M < 16 mg/ml. Twenty-four healthy controls were also studied. There was no significant difference in baseline FEV1 between IBD patients and controls. However, there was a significantly greater fall in FEV1 in the IBD patients at the concentrations of methacholine tested. The frequency of bronchial hyperresponsiveness was significantly higher in the IBD population (45%) than in controls (17%; P < 0.03). Atopy, defined by skin test, was more common in IBD patients (42%) than in controls (21%). Even when only nonatopic subjects were considered, the frequency of bronchial hyperresponsiveness was significantly higher in IBD patients (41%) than in controls (5%; P < 0.02). Thus, subclinical bronchial hyperresponsiveness is common in IBD, and may be considered a further extraintestinal manifestation. [less ▲]

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See detailPostweaning housing conditions and partner preference and sexual behavior of neonatally ATD-treated male rats.
Bakker, Julie ULg; van Ophemert, J.; Slob, A. K.

in Psychoneuroendocrinology (1995), 20(3), 299-310

Male rats were neonatally treated with cholesterol or a substance that blocks the aromatization of testosterone to estradiol (1,4,6-androstatriene-3,17-dione: ATD). At weaning (21 days) they were either ... [more ▼]

Male rats were neonatally treated with cholesterol or a substance that blocks the aromatization of testosterone to estradiol (1,4,6-androstatriene-3,17-dione: ATD). At weaning (21 days) they were either housed alone or in small groups (2-3 animals) and tested for partner preference behavior (PPB) in adulthood. Choice was between an estrous female and an active male (Part I) and between an estrous female and an ATD-male (Part II). Tests were carried out in a 3-compartment box. Social isolation did not have major effects on PPB except when sexual interaction with the stimulus animals was prevented (Part I). In this case, isolates (ATD and control) showed higher preference scores (PS) for the estrous female and spent less time in the empty middle compartment. When the choice was between an estrous female and an ATD-male, partner PS decreased in all males, most clearly in ATD-males. The latter animals spent more time with the stimulus ATD-male than they had done in previous PPB tests with the normal stimulus male. In contrast to partner preference behaviors, sexual behavior was clearly affected by social isolation. Isolates (ATD and control) displayed lower frequencies of mounts and intromissions. These effects persisted over consecutive tests. Ejaculation was not affected. In conclusion, the present results confirm earlier findings about the significance of neonatal endocrine conditions for the organization of adult PPB in male rats. The presence or absence of social conspecifics after weaning appears to have little influence on adult PPB. [less ▲]

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See detailComparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone.
Roux, C.; Gennari, C.; Farrerons, J. et al

in Arthritis and Rheumatism (1995), 38(6), 851-8

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with ... [more ▼]

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with radiologic lesions characteristic of Paget's disease of bone and serum alkaline phosphatase (AP) concentrations at least twice the upper limit of normal, in a prospective, randomized, double-blind, multicenter clinical trial lasting 6 months. Patients were randomly allocated into 1 of 3 treatment groups: tiludronate for 3 months followed by placebo for 3 months, tiludronate for 6 months, or etidronate for 6 months. Serum AP levels and urinary hydroxyproline excretion were measured at baseline and after 3 months and 6 months. Patients with a reduction of at least 50% in the serum AP concentration were considered to be responders. RESULTS: After 3 months, the proportion of responders was higher in the tiludronate group (57.4%) than in the etidronate group (13.9%) (P < 0.0001). In the etidronate group, this percentage was lower among patients who had received previous treatment with a bisphosphonate (2.3%) than among those who had not (28.6%) (P < 0.01). Previous bisphosphonate treatment was not associated with response in the tiludronate group. After 6 months, the proportion of responders did not differ between the 2 tiludronate groups (60.3% and 70.1%), but was lower in the etidronate group (25.3%) (P < 0.0001). There was a higher proportion of patients with treatment-resistant disease (< 25% reduction of serum AP) in the etidronate group (51.9%) than in the tiludronate 3-month group (17.9%) or the tiludronate 6-month group (19.5%) (P < 0.0001). Gastrointestinal disturbances were more common, and occurred earlier, with tiludronate, but they were mostly mild, requiring no treatment. CONCLUSION: Tiludronate at 400 mg/day for 3 months or 6 months is more effective than the same dosage of etidronate for 6 months in the treatment of Paget's disease. [less ▲]

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See detailEffects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism.
Oelkers, W.; Foidart, Jean-Michel ULg; Dombrovicz, N. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(6), 1816-21

Combined hormonal oral contraceptives (OCs) may lead to a mild rise in blood pressure and body weight. In rare instances, large increments in blood pressure are measured. We investigated the effect of a ... [more ▼]

Combined hormonal oral contraceptives (OCs) may lead to a mild rise in blood pressure and body weight. In rare instances, large increments in blood pressure are measured. We investigated the effect of a combination of ethinyl estradiol (EE) plus a progestogen with antimineralocorticoid, i.e. natriuretic, properties [Drospirenone (DRSP)] on body weight, blood pressure, the renin-aldosterone system, atrial natriuretic factor, plasma lipids, and glucose tolerance. It is anticipated that this will lead to the development of an OC that does not raise body weight or blood pressure. Four groups of 20 women each received 30 micrograms EE plus 3 mg DRSP (group A), 20 micrograms EE plus 3 mg DRSP (group B), 15 micrograms EE plus 3 mg DRSP (group C), and, as a control OC, 30 micrograms EE plus 150 micrograms levonorgestrel (Microgynon, Schering; group D) for 6 months. During the OC-free control cycles before and after treatment and throughout treatment, the target parameters were measured. Between the pretreatment cycle and the sixth treatment cycle, mean body weight fell by 0.8 to 1.7 kg in groups A, B, and C (P < 0.05 vs. D), whereas it rose by 0.7 kg in group D. Systolic and diastolic blood pressures fell by 1-4 mm Hg in groups A, B, and C (significant for A and C vs. D) and increased by 1-2 mm Hg in group D. Renin substrate rose equally in all groups (P < 0.05), whereas PRA and plasma aldosterone rose significantly only in the DRSP groups, presumably due to sodium loss. In the DRSP groups, high density lipoprotein cholesterol rose (P < 0.05), in contrast to group D. Low density lipoprotein cholesterol fell slightly (P > 0.05), whereas triglyceride levels showed a stronger increase in the DRSP groups (P < 0.05) than in group D. All groups attained good cycle control; group A had the best. Side-effects were minimal. To our knowledge, this is the first report on a combined OC that leads to a small decrease in body weight and blood pressure. It may be especially beneficial for women susceptible for a gain in weight and a rise in blood pressure. The potential of a new oral contraceptive (OC) containing drospirenone (DRSP) to avert the moderate increases in body weight and blood pressure often associated with use of existing combined OCs was investigated in a study of four groups of 20 German women each. Group A received 30 mcg of ethinyl estradiol (EE) and 3 mg of DRSP, Group B was administered 20 mcg of EE and 3 mg of DRSP, Group C received 15 mcg of EE and 3 mg of DRSP, and Group D was given a standard OC containing 30 mcg of EE and 150 mcg of levonorgestrel. Between the pretreatment cycle and the last (sixth) treatment cycle, mean body weight fell by 0.8-1.7 kg in Groups A, B, and C, but rose by 0.7 kg in Group D. Systolic and diastolic blood pressures fell by 1-4 mm Hg in Groups A, B, and C and rose by 1-2 mm Hg in Group D. Renin substrate rose equally in all four groups, while plasma renin activity, plasma aldosterone, and high density lipoprotein cholesterol rose significantly only in the three DRSP groups and serum triglyceride levels were significantly higher in Group D than in the three DRSP groups. Glucose tolerance increases were similar in all four groups. Finally, all groups--but especially Group A--experienced good cycle control and there were no serious side effects. These findings suggest that a combined OC containing DRSP may be especially beneficial for women who have a tendency to gain weight or experience a rise in blood pressure while taking OCs. [less ▲]

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See detailEmergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea
Bellefroid, Eric J.; Marine, Jean-Christophe; Matera, A Gregory et al

in Proceedings of the National Academy of Sciences of the United States of America (1995), 92(23), 10757-61

The ZNF91 gene family, a subset of the Kruppel-associated box (KRAB)-containing group of zinc finger genes, comprises more than 40 loci; most reside on human chromosome 19p12-p13.1. We have examined the ... [more ▼]

The ZNF91 gene family, a subset of the Kruppel-associated box (KRAB)-containing group of zinc finger genes, comprises more than 40 loci; most reside on human chromosome 19p12-p13.1. We have examined the emergence and evolutionary conservation of the ZNF91 family. ZNF91 family members were detected in all species of great apes, gibbons, Old World monkeys, and New World monkeys examined but were not found in prosimians or rodents. In each species containing the ZNF91 family, the genes were clustered at one major site, on the chromosome(s) syntenic to human chromosome 19. To identify a putative "founder" gene, > 20 murine KRAB-containing zinc finger protein (ZFP) cDNAs were randomly cloned, but none showed sequence similarity to the ZNF91 genes. These observations suggest that the ZNF91 gene cluster is a derived character specific to Anthropoidea, resulting from a duplication and amplification event some 55 million years ago in the common ancestor of simians. Although the ZNF91 gene cluster is present in all simian species, the sequences of the human ZNF91 gene that confer DNA-binding specificity were conserved only in great apes, suggesting that there is not a high selective pressure to maintain the DNA targets of these proteins during evolution. [less ▲]

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See detailVaricella-zoster virus : Introduction
Rentier, Bernard ULg

in Neurology (1995), 45(12, suppl. 8), 8

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See detailPhysical Properties of Particles of Ipratropium and Clenbuterol Generated by Equipment Suitable for the Inhalation of Drugs by Calves
Genicot, Bruno; Lapp, K.; Close, Roland et al

in Research in Veterinary Science (1995), 59(2), 164-167

When solutions of ipratropium and clenbuterol were atomised at 300 kPa and 450 kPa in equipment suitable for the inhalation of drugs by calves, the numbers, velocities and diameters of the particles ... [more ▼]

When solutions of ipratropium and clenbuterol were atomised at 300 kPa and 450 kPa in equipment suitable for the inhalation of drugs by calves, the numbers, velocities and diameters of the particles produced were similar. When the pressure was increased to 600 kPa more of the particles were less than 2 microns in diameter and fewer were more than 7 microns in diameter, the fractions of the total mass of the solution generated in these size ranges were similarly increased and decreased, and the velocities of the particles were increased. At any given pressure, the numbers of particles of different sizes, and the proportions of the total mass generated, were similar for the solutions of ipratropium and clenbuterol, but a solution of saline produced more particles with a diameter less than 3 microns. Particles from the solution of ipratropium had the highest velocity and particles from the solution of clenbuterol had the lowest velocity. [less ▲]

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See detailLe cas clinique du mois. Troubles electrolytiques severes dans l'anorexie mentale.
Scheen, André ULg

in Revue Médicale de Liège (1995), 50(1), 16-7

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See detailBronchial hyperresponsiveness in active coke-oven workers.
Corhay, Jean-Louis ULg; Bury, Thierry ULg; Louis, Renaud ULg et al

in Archives of Public Health (1995), 53

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See detailInvolvement of MMP2 and MMP9 in the development of abdominal aortic aneurysms.
SakalihasanN, Natzi ULg; DELVENNE, Philippe ULg; Nusgens, Betty ULg et al

in Cell Biology International (1995), 19(3), 250-51

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See detailThe role of bisphosphonates in the prevention and treatment of osteoporosis
Reginster, Jean-Yves ULg

in Clinical Rheumatology (1995), 14(3), 22-25

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See detailThe Formation of National Elites de A. Kappeler (ed.)
Martiniello, Marco ULg

in Ethnic and Racial Studies (1995), 18(2), 421-422

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See detailHypnosis as adjunct therapy in conscious sedation for plastic surgery
Faymonville, Marie ULg; Fissette, Jean ULg; Mambourg, P.-H. et al

in Regional Anesthesia (1995), 20(2), 145-151

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See detailBovine respiratory disease complex : an european perspective
Lekeux, Pierre ULg

in Bovine Practitioner (1995), 29

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune ... [more ▼]

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune status; its environment, e.g., changes in food, temperature and humidity that lead to stress; and the presence of infectious agents, e.g., bacteria, viruses and mycoplasmas. The syndrome, in a method preferred by the author, can be classified into four grades; Grade 1, subclinical disease; Grade 2, compensated clinical disease (at this stage, the inflammatory reaction generated tends to limit the impact of the disease on the animal); Grade 3, noncompensated clinical disease (at this stage, the inflammatory reaction is excessive and must be controlled); and Grade 4, irreversible clinical disease (which threatens the animal's survival). The increase in frequency and economy impact of bovine respiratory disease complex can be correlated with the escalating industrialization of cattle production. In intensive operations, commingling of animals from multiple sources, exposure to many organisms, stress and management practices are all factors that can lead to disease. The predisposition of cattle, especially beef calves, to respiratory problems is related to their lack of functional pulmonary hardiness. Selection of breeds that demonstrate adequate pulmonary function and sufficient ventilatory reserve may help in the control of the bovine respiratory disease complex, but this approach is difficult to implement and slow to produce results. Prophylactic measures, including vaccination programs and modifying management practices to reduce stress, also have a place in preventing the bovine respiratory disease complex. Unfortunately, these measures are not always easy to put into operation and cannot completely eradicate the problem. Therapeutic strategies to minimize the economy impact of the syndrome include use of appropriate antibacterial therapy, modulation of the pulmonary inflammatory reaction and correction of mechanical disorders. [less ▲]

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