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See detailEffect of histamine on lung contractile elements in growing cattle
Jolly, Sandra ULg; Robinson, Edward; Desmecht, Daniel ULg

in American Journal of Veterinary Research (2003), 64

OBJECTIVE: To determine the effect of histamine on the contractile elements of the respiratory tract in neonatal calves and young adult cattle. SAMPLE POPULATION: Samples of trachealis muscle, bronchi ... [more ▼]

OBJECTIVE: To determine the effect of histamine on the contractile elements of the respiratory tract in neonatal calves and young adult cattle. SAMPLE POPULATION: Samples of trachealis muscle, bronchi, and intrapulmonary arteries and veins dissected from the respiratory tracts of healthy bovids (2 to 8 days and 16 to 20 months old). PROCEDURE: Histamine cumulative concentration-effect curves (10(-6) to 10(-3) M) were constructed in duplicate smooth muscle samples mounted in organ baths. Contractile responses to histamine were compared with reference contractions elicited by methacholine (10(-5) M) for airways or KCl (127 mM) for vessels. RESULTS: In young adult cattle, trachealis muscle had a substantial contractile response to histamine (84% of methacholine-induced contraction), whereas bronchi reacted slightly (15 and 20% for large and small bronchi, respectively). Although contractile responses to KCl were comparable in arteries and veins, histamine-induced contractions were greater for intrapulmonary veins than for arteries (202 vs 48% of KCl-induced contraction). In neonatal calves, histamine-induced contraction of veins also exceeded that of arteries (230 vs 54% of KCl-induced contraction); however, unlike in young adult cattle, histamine produced notable contraction of large and small bronchi (48 and 60% of methacholine-induced contraction, respectively). CONCLUSIONS AND CLINICAL RELEVANCE: Compared with intrapulmonary arteries, intrapulmonary veins have greater contractile responses to histamine in neonatal and young adult cattle. Data suggest loss of histamine responsiveness in bronchial smooth muscle as neonatal calves grow to young adults. Venodilation may be useful in treatment of lung edema in cattle. [less ▲]

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See detailLa Belgique francophone face au référendum sarrois de 1955
Lanneau, Catherine ULg

in Revue d'Allemagne et des Pays de Langue Allemande (2003), 35(4), 525-545

Since 1945, French-speaking Belgians were looking at the « Saar problem », stumbling block of Europe’s build-up, with a mixture of awe and hope. In 1955, as the inhabitants were asked to vote on a ... [more ▼]

Since 1945, French-speaking Belgians were looking at the « Saar problem », stumbling block of Europe’s build-up, with a mixture of awe and hope. In 1955, as the inhabitants were asked to vote on a peculiar status of “Europeanised” autonomous territory (within the WEU but keeping economical union with France), the coming plebiscite was seen as a good bid on Europe’s future. At first, Belgian public opinion was under the influence of optimistic statements made by official French and autonomist propaganda. After the failure of the plebiscite, Belgian journalists and diplomats tried to find some simple and often rather bombastic explanations: intern and extern weakness of France seen as over-cautious or tinted with europhobia, lack of appeal of the European idea, attractiveness of the German economical bloom, Nazi nostalgia or even perennial nationalism of the German man. Then, Saarland, having refused to be an oddity in a nation-based Europe, fell from public interest into oblivion... [less ▲]

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See detail2. “La Parure“ di Maupassant. Strategie conclusive ed echi flaubertiani
Benzoni, Pietro ULg

in Strumenti Critici (2003), 103(3), 417-438

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See detailSynthesis and characterization of new inorganic polymeric composites based on kaolin or white clay and on ground-granulated blast furnace slag
Lecomte, I.; Liégeois, Monique ULg; Rulmont, André ULg et al

in Journal of Materials Research (2003), 18(11), 2571-2579

Alkali activation of dehydroxylated kaolin or clay yielded high-strength polymeric materials, so-called geopolymers. They were synthesized by mixing the aluminosilicate with solutions of sodium ... [more ▼]

Alkali activation of dehydroxylated kaolin or clay yielded high-strength polymeric materials, so-called geopolymers. They were synthesized by mixing the aluminosilicate with solutions of sodium metasilicate and KOH followed by adding 45 wt.% of ground-granulated blast furnace slag. The influence of the aluminosilicate source, its activation temperature, and the order of mixing raw materials were studied on the workability of the blending paste, the microstructure, and the Vickers hardness of the geopolymer samples. The polymeric material is completely amorphous according to x-ray diffraction. Solid-state 27Al and 29Si magic-angle-spinning nuclear magnetic resonance showed that the geopolymer consists of AlO 4 and SiO 4 tetrahedra linked together through a polymeric network constituted by branched entities SiQ 4(4Al) and SiQ 4(3Al), but also by less-polymerized silicates SiQ 1 and SiQ 2. Scanning electron microscopy showed a homogeneous polymeric gel matrix containing unreacted slag (and quartz) grains; thermogravimetric analysis and differential scanning calorimetry exhibited a high content of water and an elevated melting point (1260 °C). Vickers hardness values are in the range of 200 MPa. [less ▲]

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See detailRegulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells.
Wislet-Gendebien, Sabine ULg; Leprince, Pierre ULg; Moonen, Gustave ULg et al

in Journal of Cell Science (2003), 116(Pt 16), 3295-302

Bone marrow stromal cells can differentiate into many types of mesenchymal cells, i.e. osteocyte, chondrocyte and adipocyte, but can also differentiate into non-mesenchymal cells, i.e. neural cells under ... [more ▼]

Bone marrow stromal cells can differentiate into many types of mesenchymal cells, i.e. osteocyte, chondrocyte and adipocyte, but can also differentiate into non-mesenchymal cells, i.e. neural cells under appropriate in vivo experimental conditions (Kopen et al., 1999; Brazelton et al., 2000; Mezey et al., 2000). This neural phenotypic plasticity allows us to consider the utilization of mesenchymal stem cells as cellular material in regenerative medicine. In this study, we demonstrate that cultured adult rat stromal cells can express nestin, an intermediate filament protein predominantly expressed by neural stem cells. Two factors contribute to the regulation of nestin expression by rat stromal cells: serum in the culture medium inhibits nestin expression and a threshold number of passages must be reached below which nestin expression does not occur. Only nestin-positive rat stromal cells are able to form spheres when they are placed in the culture conditions used for neural stem cells. Likewise, only nestin-positive stromal cells are able to differentiate into GFAP (glial fibrillary acidic protein)-positive cells when they are co-cultivated with neural stem cells. We thus demonstrated that adult rat stromal cells in culture express nestin in absence of serum after passaging the cells at least ten times, and we suggest that nestin expression by these cells might be a prerequisite for the acquisition of the capacity to progress towards the neural lineage. [less ▲]

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See detailEffect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
Mogensen, Carl Erik; Viberti, Giancarlo; Halimi, Serge et al

in Hypertension (2003), 41(5), 1063-71

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril ... [more ▼]

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP > or =140 mm Hg, <180 mm Hg, diastolic BP <110 mm Hg) were randomly assigned (age 59+/-9 years, 77% previously treated for hypertension). Results from 457 patients (intention-to-treat analysis) were available. After a 4-week placebo period, patients with albuminuria >20 and <500 microg/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg enalapril. The main outcome measures were overnight AER and supine BP. Both treatments reduced BP. Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3.0 [95% CI -5.6, -0.4], P=0.012; systolic BP -1.5 [95% CI -3.0, -0.1] diastolic BP P=0.019) and AER -42% (95% CI -50%, -33%) versus -27% (95% CI -37%, -16%) with enalapril. The greater AER reduction remained significant after adjustment for mean BP. Adverse events were similar in the 2 groups. Thus, first-line treatment with low-dose combination perindopril/indapamide induces a greater decrease in albuminuria than enalapril, partially independent of BP reduction. A BP-independent effect of the combination may increase renal protection. [less ▲]

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See detailCharacterisation of different inulin samples by DSC - Influence of polymerisation degree on melting temperature
Blecker, Christophe ULg; Chevalier, J. P.; Fougnies, C. et al

in Journal of Thermal Analysis & Calorimetry (2003), 71(1), 215-224

Melting behaviour of powder inulin has been studied by differential scanning calorimetry. DSC curves show two endothermic peaks, relative to water elimination and to inulin melting, respectively. The ... [more ▼]

Melting behaviour of powder inulin has been studied by differential scanning calorimetry. DSC curves show two endothermic peaks, relative to water elimination and to inulin melting, respectively. The second peak is dependent on inulin type and a shift to a higher temperature is observed with increasing average polymerisation degree (DP) of the sample. For similar crystallinity index, linear relations have been underlined and so predicting inulin mean DP can be done by DSC analysis. The study shows that a relatively high heating rate (25degreesC min(-1)) can be used and brings a supplementary interest by an important reduction of analysis time. [less ▲]

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See detailProstatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation.
Cornet, Anne ULg; Hanon, Emmanuel; Reiter, Eric R et al

in Prostate (The) (2003), 56(3), 220-30

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen ... [more ▼]

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen withdrawal. The regulation of PARM-1 by androgens is limited to this organ. We have studied the effects of PARM-1 overexpression in malignant prostate cells. METHODS: The PARM-1 cDNA was introduced into the rat cancer cell line MAT LyLu along with a doxycycline-dependent regulator. RESULTS: Maximal expression of PARM-1 (fivefold induction) was achieved by incubating the cells with 2 microM doxycycline for 48 hr. A study investigating the effect of PARM-1 overexpression on the transcription of 588 genes has shown that the TLP1 gene (encoding rat telomerase protein component 1) was the most up-regulated (fourfold). In addition, a dose-dependent increase in telomerase activity was observed in cells overexpressing PARM-1. In vivo, the androgen-deprived prostate showed an increased TLP1 level and increased telomerase activity. CONCLUSIONS: Increased telomerase activity is often associated with the immortalisation of cancer cell lines, particularly prostatic ones. This could mean that PARM-1 is involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells. [less ▲]

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See detailStromatopogon cladoniae sp. nova, a remarkable new lichenicolous coelomycete from Belgium
Diederich, Paul; Sérusiaux, Emmanuël ULg

in Bibliotheca Lichenologica (2003), 86

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See detailPhylogeny
Baudoin, Jean-Pierre ULg; Maquet, A.

in Plant and Soil (2003), 252(1), 55-128

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See detailMeasure Noun constructions : an instance of semantically-driven grammaticalization
Brems, Lieselotte ULg

in International Journal of Corpus Linguistics (2003), 8(2), 283-312

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See detailZur diatopischen Gliederung des alltagssprachlichen Wortgebrauchs
Möller, Robert ULg

in Zeitschrift für Dialektologie und Linguistik (2003), 70

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See detailHaplotype diversity of the myostatin gene among beef cattle breeds
Dunner, S.; Miranda, M. E.; Amigues, Y. et al

in Genetics, Selection, Evolution (2003), 35(1, JAN-FEB), 103-118

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were ... [more ▼]

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were identified which contribute to the high polymorphism (1 SNP every 100 bp) present in this small gene; twenty haplotypes were described and a genotyping method was set up using the Oligonucleotide Ligation Assay (OLA) method. Some haplotypes appeared to be exclusive to a particular breed; this was the case for 5 in the Charolaise (involving mutation Q204X) and 7 in the Maine-Anjou (involving mutation E226X). The relationships between the different haplotypes were studied, thus allowing to test the earlier hypothesis on the origin of muscular hypertrophy in Europe: muscular hypertrophy (namely m821 (del11)) was mainly spread in different waves from northern Europe milk purpose populations in most breeds; however, other mutations (mostly disruptive) arose in a single breed, were highly selected and have since scarcely evolved to other populations. [less ▲]

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See detailEffet de la géométrie et de la disposition des mobiles d'agitation sur la formation de mousse en cuve agitée
Delvigne, Frank ULg; Bruxelmane, Marc; Thonart, Philippe ULg

in Tribune de l'Eau (La) (2003), 622(2), 65-70

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See detailPhase III randomized study comparing 5 or 10 microg per kg per day of filgrastim for mobilization of peripheral blood progenitor cells with chemotherapy, followed by intensification and autologous transplantation in patients with nonmyeloid malignancies.
Andre, Marc; Baudoux, Etienne ULg; Bron, Dominique et al

in Transfusion (2003), 43(1), 50-7

BACKGROUND: It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic ... [more ▼]

BACKGROUND: It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic engraftment after autologous transplantation. STUDY DESIGN AND METHODS: A randomized, open-label, multicenter trial was carried out in patients with breast cancer, multiple myeloma, and lymphoma, in which patients were randomized to receive 5 or 10 microg per kg per day of filgrastim after standard chemotherapy to mobilize PBPCs. After high-dose chemotherapy, the components from the first two leukapheresis procedures were returned, and all patients received 5 microg per kg day of filgrastim after transplantation. RESULTS: A total of 131 patients were randomized, of whom 128 were mobilized (Group A, 5 microg/kg, n = 66; Group B, 10 microg/kg, n = 62) and 112 were transplanted. Only six patients were not transplanted because of insufficient CD34+ cell numbers. The median number of CD34+ cells collected in the first two leukapheresis procedures tended to be higher in Group B than in Group A (12.0 vs. 7.2 x 10(6)/kg, NS), but after transplantation there was no significant difference in median times to platelet (9 days in both groups) or neutrophil (8 days in both groups) engraftment or the number of platelet transfusions (three in both groups). A subsequent subgroup analysis separating patients transplanted after first- or second-line chemotherapy also showed no measurable impact of filgrastim dose on the median CD34+ cell yield or on platelet engraftment in either subgroup. CONCLUSION: PBPC mobilization with chemotherapy and 5 microg per kg of filgrastim is very efficient, and 10 microg per kg of filgrastim does not provide additional clinical benefit. [less ▲]

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See detailImiquimod-responsive basal cell carcinomas and factor XIIIa-enriched dendrocytes.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Clinical & Experimental Dermatology (2003), 28 Suppl 1

Dermal dendrocytes (DDs) are dendritic cells that exhibit immunoreactivity for factor XIIIa, and are frequently found in conjunction with basal cell carcinomas (BCCs). Imiquimod was applied to 12 ... [more ▼]

Dermal dendrocytes (DDs) are dendritic cells that exhibit immunoreactivity for factor XIIIa, and are frequently found in conjunction with basal cell carcinomas (BCCs). Imiquimod was applied to 12 superficial BCCs every 3 days for 8 weeks. One week after completion of treatment, seven lesions appeared to have resolved, while five displayed evidence of residual BCC. Prior to initiation of treatment, the seven imiquimod-responsive BCCs were surrounded by numerous DDs, whereas the five imiquimod-resistant BCCs had fewer DDs next to them at the time of entry into the study. It appears that the pretreatment density in DDs may affect the efficacy of imiquimod in eradicating skin tumours. [less ▲]

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See detailEstrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseases
Rakic, Jean-Marie ULg; Lambert, Vincent ULg; Deprez, Manuel ULg et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]

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See detailReduced Cell Turnover In Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle
Debacq, C.; Asquith, B.; Reichert, M. et al

in Journal of Virology (2003), 77(24),

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See detailDie Medien der Germanistik und die Nöte des Nachwuchses
Pontzen, Alexandra ULg

in Jahrbuch der Deutschen Schillergesellschaft (2003), XLVII

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See detailSylviculture et qualité du bois de l'épicéa en Région wallonne. Recommandations pratiques - Cahier technique n°22
Hebert, Jacques ULg; Herman, M.; Jourez, B.

in Forêt Wallonne (2003), (62), 10-13

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See detailOptimization, continuation and lack of the one-step diphosphorylation reaction. Assay of modification of the tetraethyl(pyrrolidine-2,2-diyl)bisphosphonate
Olive, Gilles ULg; Jacques, Alain

in Phosphorus, Sulfur & Silicon & the Related Elements (2003), 178(1), 33-46

The optimization of the one-step diphosphorylation reaction is reported. The synthesis of new ®-aminobisphosphonates with four- and sixmembered rings and acyclic species with several substituents on the ... [more ▼]

The optimization of the one-step diphosphorylation reaction is reported. The synthesis of new ®-aminobisphosphonates with four- and sixmembered rings and acyclic species with several substituents on the nitrogen atom and on the carbon atom bearing the two phosphorus atoms is described. [less ▲]

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See detailBinding and migration across fibronectin and VCAM-1 of cycling hematopoietic progenitor cells.
Gothot, André ULg; Giet, Olivier ULg; Huygen, Sandra et al

in Leukemia & Lymphoma (2003), 44(8), 1379-83

Using different experimental approaches, it has been established that transplantability of hematopoietic/stem progenitor cells is ineffective during transit through the cell cycle. Although primitive stem ... [more ▼]

Using different experimental approaches, it has been established that transplantability of hematopoietic/stem progenitor cells is ineffective during transit through the cell cycle. Although primitive stem cells are responsive to mitogenic stimulation in optimized ex vivo conditions, defective engraftment of generated cells may limit their detection in standard transplantation models as well as their use in clinical cell therapy. The activation level of adhesion receptors is modulated by stimulation of cytokine receptors via "inside-out" signaling. This prompted us to study the interactions of progenitor cells with fibronectin (Fn) in different phases of the cell cycle. We first demonstrated that adhesion to Fn was stimulated in S/G2 + M as compared to G0/G1, in ex vivo cultured CD34+ cells, with a predominant usage of very late antigen (VLA)-5 over that of VLA-4. We next determined that maximal Fn binding in active phases of the cell cycle limited cell motility toward stromal cell-conditioned medium. It was also observed that VLA-4 and VLA-5 ability to mediate adhesion or migration varied independently during cell cycle transit. Finally, in synchronized progenitor cells executing a first cell cycle ex vivo, a reversible increase in Fn binding was associated with a reversible decrease in adhesion to vascular cell-adhesion molecule (VCAM)-1. Overall, these observations suggest that defective engraftment of cycling stem/progenitor cells may result, at least in part, from abnormal trafficking related to changes in the activation level of adhesion receptors. [less ▲]

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See detailIntroduction of australian diploid cotton genetic variation into upland cotton
Ahoton, L.; Lacape, Jm.; Baudoin, Jean-Pierre ULg et al

in Crop Science (2003), 43(6), 1999-2005

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See detailAdaptive latitudinal trends in the mandible shape of Apodemus wood mice
Renaud, S.; Michaux, Johan ULg

in Journal of Biogeography (2003), 30(10), 1617-1628

Aim Size and shape of the mandible are investigated across the latitudinal range of the European wood mouse ( Apodemus sylvaticus), in order to address the relative importance of genetic structure ... [more ▼]

Aim Size and shape of the mandible are investigated across the latitudinal range of the European wood mouse ( Apodemus sylvaticus), in order to address the relative importance of genetic structure, insularity, and geographical gradient in patterning morphological variation. Results are compared with those on two Asiatic species of wood mice, A. argenteus and A. speciosus. Location The European wood mouse is sampled by a set of trapping localities including both, islands and mainland populations, as well as the four genetic groups identified in previous studies. The localities cover a latitudinal gradient from 55 degreesN to 36 degreesN. Methods Different Fourier methods are applied to the outlines of mandibles and their results compared in the case of A. sylvaticus. All provide similar results and allow a quantification of the size and shape variations across the geographical range of the European wood mouse. Using the method allowing for the best reduction of the informative data set, a comparison of the European wood mouse with the two Asiatic species was performed. Results Within the European wood mouse A. sylvaticus, a strong latitudinal gradient in mandible shape overrides the influence of insularity and genetic structure. Yet, random morphological divergence in insular conditions can be identified as a secondary process of shape differentiation. Size displays no obvious pattern of variation, neither with insularity or latitude. A comparison with two other species of wood mice suggests that a similar latitudinal gradient in mandible shape exists in different species, mandibles being flatter in the north and wider in the south. Main conclusion The latitudinal gradient in mandible shape observed in the three species of wood mice is interpreted as an intraspecific adaptive response to gradual changes in feeding behaviour. [less ▲]

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See detailAbsolute and relative quantification : beyond mutually exclusive word classes.
Brems, Lieselotte ULg; Davidse, Kristin

in Belgian Journal of English Language and Literatures. New Series (2003), 1

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See detailL'assurance dépendance: quels risques à assurer?
Jousten, Alain ULg

in Risques (2003), 55

La perte d'autonomie est un thème d'actualité dans bon nombre de pays développés, notamment vu le processus de vieillissement démographique qui est en cours. Malgré ce constat commun à la majeure partie ... [more ▼]

La perte d'autonomie est un thème d'actualité dans bon nombre de pays développés, notamment vu le processus de vieillissement démographique qui est en cours. Malgré ce constat commun à la majeure partie des pays, les réponses apportées ou proposées dans les différents pays semblent différer de façon fondamentale. Nous proposons différentes classifications qui permettent de mieux comprendre les enjeux quant à l'étendue et le financement des prestations couvertes par les systèmes d'assurance dépendance. [less ▲]

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See detailCalculation of the scattering coefficient of a sine-shaped surface by solving the Helmholtz integral
Embrechts, Jean-Jacques ULg; De Geetere, L.; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 67-74

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See detailRevisiting The Ramachandran Plot: Hard-Sphere Repulsion, Electrostatics, And H-Bonding In The Alpha-Helix
Ho, Bk.; Thomas, Annick ULg; Brasseur, Robert ULg

in Protein Science : A Publication of the Protein Society (2003), 12(11), 2508-22

What determines the shape of the allowed regions in the Ramachandran plot? Although Ramachandran explained these regions in terms of 1-4 hard-sphere repulsions, there are discrepancies with the data where ... [more ▼]

What determines the shape of the allowed regions in the Ramachandran plot? Although Ramachandran explained these regions in terms of 1-4 hard-sphere repulsions, there are discrepancies with the data where, in particular, the alphaR, alphaL, and beta-strand regions are diagonal. The alphaR-region also varies along the alpha-helix where it is constrained at the center and the amino terminus but diffuse at the carboxyl terminus. By analyzing a high-resolution database of protein structures, we find that certain 1-4 hard-sphere repulsions in the standard steric map of Ramachandran do not affect the statistical distributions. By ignoring these steric clashes (NH(i+1) and O(i-1)C), we identify a revised set of steric clashes (CbetaO, O(i-1)N(i+1), CbetaN(i+1), O(i-1)Cbeta, and O(i-1)O) that produce a better match with the data. We also find that the strictly forbidden region in the Ramachandran plot is excluded by multiple steric clashes, whereas the outlier region is excluded by only one significant steric clash. However, steric clashes alone do not account for the diagonal regions. Using electrostatics to analyze the conformational dependence of specific interatomic interactions, we find that the diagonal shape of the alphaR and alphaL-regions also depends on the optimization of the NH(i+1) and O(i-1)C interactions, and the diagonal beta-strand region is due to the alignment of the CO and NH dipoles. Finally, we reproduce the variation of the Ramachandran plot along the alpha-helix in a simple model that uses only H-bonding constraints. This allows us to rationalize the difference between the amino terminus and the carboxyl terminus of the alpha-helix in terms of backbone entropy. [less ▲]

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See detailLarval development of Myzostoma cirriferum (Myzostomida)
Eeckhaut, I.; Fievez, Laurence ULg; Muller, M. C.

in Journal of Morphology (2003), 258

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and ... [more ▼]

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and the metatrochophore. The protrochophore is a ball-shaped larva present in culture from 18-48 h after egg laying. It has no internal organs and its body is made of three cell types: covering cells and ciliated cells that are external and surrounded by a cuticle, and resting cells that fill the blastocoel. The trochophore is a pear-shaped larva that develops 20-72 h after egg laying; the body includes the same three cell types as the previous stage. The metatrochophore is a pear-shaped larva that develops between 40 h and 14 days and is characterized by the presence of two bundles of four chaetae. When fully developed, the metatrochophore has a digestive system (made of a pharynx, an esophagus, and a blind digestive pouch), two pairs of protonephridia, and a nervous system composed of a supraesophageal ganglion, circumesophageal connectives, and dorsal and ventral nerves. Metamorphosis generally occurs 7 days after egg laying. At that time, the metatrochophore loses its chaetae and becomes pleated ventrally. This ultrastructural analysis suggests that chaetae and the five ventral longitudinal nerve cords of M. cirriferum metatrochophores are homologous structures to those observed in some polychaete trochophores. Coupled with recent phylogenetic analyses, where the Myzostomida are placed outside the Annelida, homologies between myzostomid and polychaete larvae support the view that a trochophore appeared early during the spiralian evolution [less ▲]

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See detailEuropean COST action F3 on structural dynamics. Working group 3: identification of non-linear systems. Introduction and conclusions
Golinval, Jean-Claude ULg; Kerschen, Gaëtan ULg; Lenaerts, Vincent et al

in Mechanical Systems & Signal Processing (2003)

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See detailSapling diversity in canopy gaps in an Ecuadorian rain forest.
Salvador-Van Eysenrode, D; Bogaert, Jan ULg; Zak-Mnacek, V et al

in Forest Science (2003), 49(6), 909-917

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See detailp-mode Oscillations of alpha Cen A
Thoul, Anne ULg; Scuflaire, Richard ULg; Vatovez, B. et al

in Astrophysics & Space Science (2003), 284

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (2002) and the data derived from the spectroscopic analysis of Neuforge and Magain (1997). The seismological ... [more ▼]

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (2002) and the data derived from the spectroscopic analysis of Neuforge and Magain (1997). The seismological data obtained by Bouchy and Carrier (2001, 2002) do help improve our knowledge of the evolutionary status of the system. All the constraints are satisfied with a model which gives an age of about 6 Gyr for the binary. [less ▲]

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See detailLeçons de l’éphémère. La Cour d’arbitrage et le "Renouveau’ électoral" – La Cour d’arbitrage et la suspension
Rosoux, Géraldine ULg

in Revue Belge de Droit Constitutionnel (2003)

The articles analyzes the electoral reform of 2003 and points out the competence of the Belgian constitutional Court to suspend legislative norms.

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See detailQuels rôles et quelle formation pour les tuteurs intervenant dans des dispositifs de formation à distance ?
Denis, Brigitte ULg

in Distances et Savoirs (2003), 1(1), 19-46

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif ... [more ▼]

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. [less ▲]

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See detailAn X-ray Rietveld, infrared, and Mossbauer spectral study of the NaMn(Fe1-xInx)(2)(PO4)(3) alluaudite-type solid solution
Hatert, Frédéric ULg; Hermann, Raphaël ULg; Long, Gary J. et al

in American Mineralogist (2003), 88(1), 211-222

Several compounds of the NaMn(Fe1-xInx)(2)(PO4)(3) solid solution were synthesized by solid state reaction in air; pure alluaudite-like compounds were obtained for x = 0.00 to 1.00. X-ray Rietveld ... [more ▼]

Several compounds of the NaMn(Fe1-xInx)(2)(PO4)(3) solid solution were synthesized by solid state reaction in air; pure alluaudite-like compounds were obtained for x = 0.00 to 1.00. X-ray Rietveld refinements indicate the presence of Na+ at the A1 and A2' sites, Mn2+ at the M1 site, and Fe2+, Fe3+, and In3+ at the M2 site. The presence of small amounts of In3+ at the M I site, and Mn2+ at the M2 site, indicates a partially disordered distribution between these cations. A good correlation was also established between the M1-M2 bond distance and the beta angle of the alluaudite-like compounds. The disordered distribution of Fe2+, Fe3+, and In3+ at the M2 site is confirmed by the broadness of the infrared absorption bands. The Mossbauer spectra, measured between 90 and 295 K, were analyzed in terms of a model that takes into account the next-nearest neighbor interactions around the M2 crystallographic site. In all cases these spectra reveal the unexpected presence of small amounts of Fe2+ at the M2 site, an amount that decreases as the In3+ content increases. The Fe2+ and Fe3+ isomer shifts are typical of the alluaudite structure and vary with temperature, as expected from a second-order Doppler shift. The derived iron vibrating masses and Mossbauer lattice temperatures are within the expected range of values for iron cations in an octahedral environment. The Fe2+ and Fe3+ quadrupole splittings are also typical of the alluaudite structure and the temperature dependence of the Fe2+ quadrupole splitting was fit with the model of Ingalls (1964), which yielded a ground state orbital splitting of ca. 380 to 570 cm(-1) for the Fe2+ sites. [less ▲]

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See detailApolipoprotein L-I is the trypanosome lytic factor of human serum.
Vanhamme, Luc; Paturiaux-Hanocq, Francoise; Poelvoorde, Philippe et al

in Nature (2003), 422(6927), 83-7

Human sleeping sickness in east Africa is caused by the parasite Trypanosoma brucei rhodesiense. The basis of this pathology is the resistance of these parasites to lysis by normal human serum (NHS ... [more ▼]

Human sleeping sickness in east Africa is caused by the parasite Trypanosoma brucei rhodesiense. The basis of this pathology is the resistance of these parasites to lysis by normal human serum (NHS). Resistance to NHS is conferred by a gene that encodes a truncated form of the variant surface glycoprotein termed serum resistance associated protein (SRA). We show that SRA is a lysosomal protein, and that the amino-terminal alpha-helix of SRA is responsible for resistance to NHS. This domain interacts strongly with a carboxy-terminal alpha-helix of the human-specific serum protein apolipoprotein L-I (apoL-I). Depleting NHS of apoL-I, by incubation with SRA or anti-apoL-I, led to the complete loss of trypanolytic activity. Addition of native or recombinant apoL-I either to apoL-I-depleted NHS or to fetal calf serum induced lysis of NHS-sensitive, but not NHS-resistant, trypanosomes. Confocal microscopy demonstrated that apoL-I is taken up through the endocytic pathway into the lysosome. We propose that apoL-I is the trypanosome lytic factor of NHS, and that SRA confers resistance to lysis by interaction with apoL-I in the lysosome. [less ▲]

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See detailBiogeographical Observations On Four Scolytids (Coleoptera, Scolytidae) And One Lymexylonid (Coleoptera, Lymexylonidae) In Wallonia (Southern Belgium)
Henin, Jm.; Huart, O.; Rondeux, Jacques ULg

in Belgian Journal of Zoology (2003), 133(2), 175-180

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999 ... [more ▼]

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999. Consequently, the ambrosia beetles Trypodendron domesticum L. and T. signatum (Fabricius) (Coleoptera, Scolytidae) initiated outbreaks and, in 2000 and 2001, they heavily contributed to the depreciation of nearly 1,600,000 m3 of stem volume (to upper limit girth of 22 cm) in the natural regions of “Ardenne” and “Belgian Lorraine”. Because of the lack of biogeographical data on both insects, of their conspicuous aggressiveness towards apparently healthy trees and of the economic importance of the beech wood chain in Belgium, a large-scale survey was undertaken in 2001, in order to outline the range of both ambrosia beetles in Wallonia. To this effect, a network of 172 traps baited with ethanol was set up, attempting to cover the Walloon beech forest as representatively as possible. Two other scolytids and one lymexylonid were also frequently caught, which made it possible to outline their regional distribution too. Although the damage was limited to the Ardenne and Belgian Lorraine, T. domesticum and T. signatum are widespread throughout Wallonia. We discuss these results, their long-term validity, the secondary pest status of these insects and the need for a permanent monitoring of the major forest pest species and diseases. [less ▲]

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See detailPatterns of molecular and morphological variation in Leucobryum albidum, L. Glaucum, and L-juniperoideum (Bryopsida)
Vanderpoorten, Alain ULg; Boles, S.; Shaw, A. J.

in Systematic Botany (2003), 28(4, OCT-DEC), 651-656

Restriction digest patterns from 18S-26S nuclear ribosomal DNA internal transcribed spacers (ITS) were employed to investigate delineation between the morphologically similar moss species Leucobryum ... [more ▼]

Restriction digest patterns from 18S-26S nuclear ribosomal DNA internal transcribed spacers (ITS) were employed to investigate delineation between the morphologically similar moss species Leucobryum glaucum, L. juniperoideum, and L. albidum. Discriminant analysis allowed assignment of specimens to haplotypes based on their morphological features and supported the recognition of L. glaucum and L. albidum. In contrast, L. albidum and L. juniperoideum both corresponded to the same haplotype. Many populations could be readily assigned to either L. glaucum or L. albidum by their morphological features. However, morphological variation between these two species was continuous and one of the ITS haplotypes could not be unambiguously characterized by its morphology. Genetically and morphologically identifiable specimens of L. albidum were sampled in Europe and North America, in contrast to the traditional interpretation of L. albidum as a North American endemic. Although L. albidum seems to have a more southern-Atlantic distribution pattern than L. glaucum, the two species occupy broadly overlapping geographic ranges and were sometimes found intermixed. [less ▲]

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See detailTraitement de données volumineuses par ensemble d'arbres aléatoires
Geurts, Pierre ULg

in Revue des nouvelles technologies de l'information, Numéro spécial entreposage et fouille de données (2003), 1

Cet article présente une nouvelle méthode d'apprentissage ba-sée sur un ensemble d'arbres de décision. Par opposition à la méthode traditionnelle d'induction, les arbres de l'ensemble sont construits en ... [more ▼]

Cet article présente une nouvelle méthode d'apprentissage ba-sée sur un ensemble d'arbres de décision. Par opposition à la méthode traditionnelle d'induction, les arbres de l'ensemble sont construits en choisissant les tests durant le développement de manière complètement aléatoire. Cette méthode est comparée aux arbres de décision et au bagging sur plusieurs problèmes de classification. Grâce aux choix aléatoires des tests, les temps de calcul de cet algorithme sont comparables à ceux des arbres traditionnels. Dans le même temps, la méthode se révèle beaucoup plus précise que les arbres et souvent significativement meilleure que le bagging. Ces caractéristiques rendent cette méthode particulièrement adaptée pour le traitement de bases de données volumineuses. [less ▲]

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See detailAnalysis of bivariate tail dependence using extreme values copulas: An application to the SOA medical large claims database
Cebrian, Ana; Denuit, Michel; Lambert, Philippe ULg

in Belgian Actuarial Bulletin (2003)

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; Portetelle, Daniel ULg et al

in Yeast (Chichester, England) (2003), 20(S1),

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See detailGene flow among wild Phaseolus lunatus L. populations in the Central Valley of Costa Rica
Ouedraogo, M.; Maquet, A.; Baudoin, Jean-Pierre ULg

in Annual Report Bean Improvement Cooperative (2003), 46

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See detailA note on the age of radioactive tracers
Delhez, Eric ULg; Deleersnijder, Eric; Mouchet, Anne ULg et al

in Journal of Marine Systems (2003), 38(3-4), 277-286

wThe age of a water mass is often estimated experimentally using the radio-age computed from the distribution of a radioactive tracer (radiocarbon, helium-tritium). Deleersnijder et al. [J. Mar. Syst. 28 ... [more ▼]

wThe age of a water mass is often estimated experimentally using the radio-age computed from the distribution of a radioactive tracer (radiocarbon, helium-tritium). Deleersnijder et al. [J. Mar. Syst. 28 (2001) 229.] have shown that the radio-age underestimates the age of the water and is larger than the age of the radioactive tracer used for its evaluation. This result is generalized here to radio-ages computed from the ratio of two radioactive tracers. The differences between the different ages are also studied analytically and numerically as functions of the decay rate of the radioactive tracers. For small decay rates, the difference between the age of the water mass and the radio-age is shown to be proportional to the decay rate. It depends also on the level of mixing in the system; even radioactive tracers with small decay rates can provide poor estimates of the age of the water mass in a strongly diffusive flow. For small half lives, both the radio-age and the age of radioactive tracers decrease as the inverse of the square root of the decay rate. The same analysis applies to some extent to the estimates of the age of a water mass from stable tracers with known time dependent sources (e.g. chloroflurocarbons). (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailDe Cheddar- en Creswell-spitsen van Zeijen (Dr.): ‘projectielen’ of ‘messen’?
Rots, Veerle ULg; Stapert, Dick; Johanssen, Lykke

in Paleo-Aktueel (2003), 13

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See detailPolitiques foncières et mécanismes fonciers en Wallonie : objectifs politiques, outils juridiques et mise en œuvre
Dubois, O.; Halleux, Jean-Marie ULg

in Ruimte & Planning (2003), (4), 265-283

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See detailAlong or across front ocean survey strategy? The estimation of quasi-geostrophic vertical velocities and temperature fluxes
Rixen, Michel; Allen, J. T.; Pollard, R. T. et al

in Geophysical Research Letters (2003), 30(5), 61-68

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio ... [more ▼]

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio-chemical properties when the front is sufficiently developed. The cruise design based on the optimal reconstruction of the density fields does however not imply that derived variables like quasi-geostrophic (QG) vertical velocities and temperature fluxes also exhibit minimal associated errors. Here we present results of optimized sampling strategies for diagnostic QG vertical velocities (wQG) and temperature fluxes (θQG) derived from the omega equation. Results are illustrated in the same framework, for the Iceland-Faroes oceanic frontal area and for a control model and reveal that at these spatio-temporal scales, the unusual AL may also provide better estimations of vertical velocities and temperature fluxes compared to the classic AC, especially when the front is sufficiently developed. [less ▲]

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See detailLe catastérisme chez Homère. Le cas d'Orion
Renaud, Jean-Michel ULg

in Gaia. Revue interdisciplinaire sur la Grèce archaïque (2003), 7

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See detailEpisode de dyspnée consécutive à une intoxication par l’ergot dans une exploitation laitière
Brihoum, Mounir ULg; Desmecht, Daniel ULg; Bony, S. et al

in Annales de Médecine Vétérinaire (2003), 147(5), 353-358

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These ... [more ▼]

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These troubles can be compared to many observations done in humans after long lasting treatments with ergot derivatives [less ▲]

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See detailToward a better control of internal structure and external morphology of mesoporous silicas synthesized using a nonionic surfactant
Léonard, Alexandre ULg; Blin, J. L.; Robert, M. et al

in Langmuir (2003), 19(13), 5484-5490

Mesoporous silicas with controlled morphologies have been synthesized using decaoxyethylene cetyl ether [C 16(EO) 10] as a surfactant (10 wt % in aqueous solution). A large series of characterization ... [more ▼]

Mesoporous silicas with controlled morphologies have been synthesized using decaoxyethylene cetyl ether [C 16(EO) 10] as a surfactant (10 wt % in aqueous solution). A large series of characterization results (SEM, TEM, XRD, and nitrogen adsorption-desorption analysis) have demonstrated how the surfactant/silica molar ratio as well as hydrothermal treatment conditions can drastically influence not only the regular organization of the compounds on the nanometer scale but also the morphogenesis of the particles at the micrometer level. High loadings of a silica precursor yield highly structured mesoporous compounds with a morphology of ropes, gyroids and toroids whereas an increase of the surfactant/silica molar ratio results in spherical materials with a disordered channel array. A phase transition from hexagonal to disordered structure and then again to a regular hexagonal array with increasing gel heating temperature from 40 to 80°C has been evidenced. [less ▲]

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See detailTrois nouveaux indices de réalisme dans l'auto-évaluation des performances
Leclercq, Dieudonné ULg; Poumay, Marianne ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 15-16

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See detailRheumatoid hand joint synovitis: gray-scale and power Doppler US quantifications following anti-tumor necrosis factor-alpha treatment: pilot study
Ribbens, Clio ULg; Andre, Béatrice ULg; Marcelis, Stefaan et al

in Radiology (2003), 229(2), 562-569

PURPOSE: To evaluate by using B-mode and power Doppler ultrasonography (US) and clinical assessment the response of hand joint synovitis in patients with active rheumatoid arthritis (RA) to treatment with ... [more ▼]

PURPOSE: To evaluate by using B-mode and power Doppler ultrasonography (US) and clinical assessment the response of hand joint synovitis in patients with active rheumatoid arthritis (RA) to treatment with the anti-tumor necrosis factor-alpha agent infliximab. MATERIALS AND METHODS: Wrists, metacarpophalangeal (MCP) joints, and proximal interphalangeal (PIP) joints in 11 patients with active RA were assessed before and 6 weeks after three infliximab infusions. US assessment was performed at a single site in the MCP and PIP joints and at two sites (radiocarpal and intercarpal) in the wrists. Twenty measurements were performed in the wrists; 110 measurements, in the MCP joints; and 103 measurements, in the PIP joints. Two wrists and seven PIP joints were excluded owing to complete joint destruction. US parameters (synovial thickness, number of US-positive joints [ie, with synovial thickness > or = 1 mm], cumulative synovial thickness index, and presence of Doppler signal) and clinical parameters (swollen joint count) were independently assessed and compared with baseline values by using the McNemar chi2 and paired Student t tests. RESULTS: After infliximab treatment, there was a significant decrease in the mean numbers of swollen and US-positive joints and in the cumulative synovial thickness (P <.05). The mean synovial thickness decreased in all joints swollen at baseline and in the MCP and PIP joints not swollen at baseline (P <.01). Change from baseline cumulative synovial thickness correlated significantly with change in disease activity score (r = 0.69, P <.05). The number of positive Doppler US signals decreased significantly (in 13 US-positive joints at baseline, in five after treatment; P <.05). CONCLUSION: US is a feasible imaging modality for measurement of the response of RA small-joint synovitis to therapy. [less ▲]

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See detailDiagnosis and monitoring of pregnancy in sheep: reality and perspectives
El Amiri, Bouchra; Karen, Aly; Cognié, Yves et al

in Productions Animales (2003), 16(2), 79-90

The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non ... [more ▼]

The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non-pregnant ewes, and the possibility to determine fetal numbers are carefully analysed. The progesterone assay is accurate as early as day 17th after fecundation; but the fertilization day must be precisely known. The pregnancy specific or associated glycoproteins (PSPB/PAG) assay is highly sensitive and specific at day 22 in blood and at day 32 in milk samples. However, this assay does not allow to predict the fetal number. The ultrasonography B-mode used on 30 days of gestation gives very good or excellent performance in terms of sensitivity and specificity depending on the practitioner. The method is also able to predict the real time fetal number. [less ▲]

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See detailA recombinant 31.5 kDa keratinase and a crude exo-antigen from Microsporum canis fail to protect against a homologous experimental infection in guinea pigs.
Descamps, Frederic F; Brouta, Frederic; Vermout, Sandy M et al

in Veterinary Dermatology (2003), 14(6), 305-312

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three ... [more ▼]

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three times at two-week intervals with either the keratinase, the exo-antigen or the adjuvant alone. Cutaneous challenge was performed blindly. Both humoral and cellular-specific immune responses to M. canis antigens were evaluated every 14 days, while a blind evaluation of clinical lesion development and fungal persistency in skin were monitored weekly. Vaccination induced very high and significant (P < 0.01) antibody responses towards both antigens. High cell-mediated immune responses to both immunogens were also induced by vaccination. After challenge, however, scores reflecting the severity of dermatophytic lesions did not differ significantly between vaccinated and control groups at any time after challenge. These results suggest that, in the guinea pig, the induction of specific immune responses against the M. canis-secreted antigens used in this study are not protective against challenge exposure. [less ▲]

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See detailNMR study of surfactant molecules intercalated in montmorillonite and silylated montmorillonite
Grandjean, Jean ULg; Bujdak, Janec; Komadel, Peter

in Clay Minerals (2003), 38

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See detailApplication of a damage model to an aluminium alloy
Castagne, Sylvie; Habraken, Anne ULg; Cescotto, Serge ULg

in International Journal of Damage Mechanics (2003), 12(1), 5-30

An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the ... [more ▼]

An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the local approach of ductile fracture, effective stresses associated to damage variables are introduced. The damage law allows a continuous description of crack appearance. After a brief description of the model, its identification and its validation for an aluminum alloy are presented. Finally, the research of a global rupture criterion associated to this model is introduced. [less ▲]

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See detailA magnetic and Mossbauer spectral study of TbFe11Ti and TbFe11TiH
Piquer, C.; Hermann, Raphaël ULg; Grandjean, François-Xavier ULg et al

in Journal of Physics : Condensed Matter (2003), 15(43), 7395-7409

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering ... [more ▼]

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering temperature, magnetization, magnetic hyperfine fields, and isomer shifts as a result of lattice expansion. Further, the insertion of hydrogen reinforces the basal magnetic anisotropy of the terbium sublattice and, as is shown by ac susceptibility measurements and thermomagnetic analysis, the spin reorientation observed in TbFe11Ti at 338 K disappears in TbFe11TiH. The Mossbauer spectra have been analysed with a model that considers both the easy magnetization direction and the distribution of titanium atoms in the near-neighbour environment of the three crystallographically distinct iron sites. The assignment and the temperature dependencies of the hyperfine fields and isomer shifts are in complete agreement with a Wigner-Seitz cell analysis of the three iron sites in RFe11Ti and RFe11TiH, where R is a rare-earth element. A complete analysis of the quadrupole interactions in both magnetic phases and in the paramagnetic phase of TbFe11Ti supports the Mossbauer spectral analysis, and indicates that in the basal magnetic phase the iron magnetic moments are oriented along the equivalent [100] and [010] directions of the unit cell. [less ▲]

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See detailEffect of polystyrene particles on lung mirovascular permeability in isolated perfused rabbit lungs : role of size and surface proporties
Hamoir, J.; Nemmar, A.; Halloy, D. et al

in Toxicology and Applied Pharmacology (2003), 190

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See detailIncidence and survival rate of women with cervical cancer in the Greater Amsterdam area.
BULK, Saskia ULg; Visser, O.; Rozendaal, L. et al

in British journal of cancer (2003), 89(5), 834-9

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a ... [more ▼]

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a cancer registry in the Greater Amsterdam area. The incidence rate of squamous cell carcinoma decreased significantly from 9.2/100,000 women in 1988 to 5.9/100,000 in 2000 (P<0.001). The incidence rate of adenocarcinomas remained stable. After adjustment for age, stage and lymph node involvement, the relative risk of death was 1.6 times higher for patients with adenocarcinomas than for patients with squamous cell carcinoma (95% CI 1.2-2.1). The decreased survival was related to histological type, as the effect remained significant after correction for confounding factors. Over time, the prognosis of women with squamous cell carcinoma improved significantly. No significant change was observed for women diagnosed with adenocarcinoma. These results suggest that the screening programme in The Netherlands as executed in the Greater Amsterdam area is associated with a decreased incidence and increased survival of patients with squamous cell carcinoma, but fails to detect (pre)malignant lesions of adenocarcinoma. Since more than 92% of adenocarcinomas and its precursors contain high-risk HPV, adding HPV testing to cytologic screening might improve the present screening programme in detecting adenocarcinoma and its precursor lesions. [less ▲]

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See detailSpontaneous zygogenesis in Escherichia coli, a form of true sexuality in prokaryotes.
Gratia, Jean*-Pierre; Thiry, Marc ULg

in Microbiology (2003), 149(Pt 9), 2571-84

A new type of mating, differing from classic conjugation and previously observed in a certain strain of Escherichia coli K-12, has also been found in strains derived from ordinary F- cells of E. coli K-12 ... [more ▼]

A new type of mating, differing from classic conjugation and previously observed in a certain strain of Escherichia coli K-12, has also been found in strains derived from ordinary F- cells of E. coli K-12 exposed to an exogenous factor originating in an E. coli clinical isolate. Immunofluorescence and electron microscopy after single and double labelling of DNA were used to produce evidence in favour of a novel mating mechanism by cell contact at the poles of the bacterial rod. These findings are supported by genetic analyses indicating complete genetic mixing. Unstable complementing diploids were formed, which throw off phenotypically haploid cells, of which some showed a parental phenotype and some were true genetic recombinants. Recombination was observed even when one parent was a UV-inactivated F- RecA- strain. The name 'spontaneous zygogenesis' (Z-mating, for short) is proposed for this kind of mating. [less ▲]

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See detailMarine mammals from Northeast Atlantic: relationship between their trophic status as determined by delta C-13 and delta N-15 measurements and their trace metal concentrations
Das, Krishna ULg; Beans, Cristina; Holsbeek, Ludo et al

in Marine Environmental Research (2003), 56(3),

The relationship between trophic position through delta(13)C and delta(15)N and trace metal concentrations (Zn, Cd, Cu and Hg) was investigated in the tissues of six marine mammal species from the ... [more ▼]

The relationship between trophic position through delta(13)C and delta(15)N and trace metal concentrations (Zn, Cd, Cu and Hg) was investigated in the tissues of six marine mammal species from the Northeast Atlantic: striped dolphin Stenella coeruleoalba, common dolphin, Delphinus delphis. Atlantic white-sided dolphin Lagenorhynchus acutus, harbour porpoise Phocoena phocoena, white beaked-dolphin Lagenorhynchus albirostris, grey seal Halichoerus grypus stranded on French Channel and Irish coasts. White-beaked dolphins, harbour porpoises, white-sided dolphins, common and striped dolphins display the same relative and decreasing trophic position, as measured by delta(15)N values, along both the Irish and French channel coasts, reflecting conservative trophic habits between these two places. Hepatic and renal Cd concentrations were significantly correlated to muscle delta(13)C and delta(15)N values while Hg, Zn and Cu did not. These results suggest that Cd accumulation is partly linked to the diet while other factors Such as age or body condition might explain Hg, Zn or Cu variability in marine mammals. Combined stable isotope and trace metal analyses appear to be useful tools for the study of marine mammal ecology. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailImmunocytochemical detection of DNA and RNA in endosymbiont-bearing trypanosomatids.
Motta, Maria Cristina M; de Souza, Wanderley; Thiry, Marc ULg

in FEMS Microbiology Letters (2003), 221(1), 17-23

Research about the kinetoplast of trypanosomatids has yielded valuable information about the organization of extranuclear structure. However, the ultrastructural localization of nucleic acids within these ... [more ▼]

Research about the kinetoplast of trypanosomatids has yielded valuable information about the organization of extranuclear structure. However, the ultrastructural localization of nucleic acids within these protozoa remains uncertain. We have applied cytochemical and immunocytochemical approaches to precisely identify DNA and RNA in lower endosymbiont-bearing trypanosomatids. Using the Terminal deoxynucleotidyl Transferase (TdT) immunogold technique, we showed that nuclear DNA is seen associated with the nuclear envelope during the trypanosomatid cell cycle. By combining the TdT technique with the acetylation method, which improves the contrast between structures containing fibrils and granules, we have demonstrated that the nucleolus of endosymbiont-bearing trypanosomatids is composed of two constituents: a granular component and a DNA-positive fibrillar zone. Moreover, we revealed that DNA of endosymbiotic bacteria consisted of electron-dense filaments which are usually in close contact with the prokaryote envelope. Using a Lowicryl post-embedding immunogold labeling procedure with anti-RNA antibodies, we showed the presence of RNA not only over the cytoplasm, the interchromatin spaces and the nucleolus, but also over the kinetoplast and virus-like particles present in Crithidia desouzai. [less ▲]

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See detailAltered neuronal excitability in cerebellar granule cells of mice lacking calretinin
Gall, D.; Roussel, C.; Susa, I. et al

in Journal of Neuroscience (2003), 23(28), 9320-9327

Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar ... [more ▼]

Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar granule cells, which provide the major excitatory input to Purkinje cells through parallel fibers. Calretinin-deficient mice exhibit dramatic alterations in motor coordination and Purkinje cell firing recorded in vivo through unknown mechanisms. In the present study, we used patch-clamp recording techniques in acute slice preparation to investigate the effect of a null mutation of the calretinin gene on the intrinsic electroresponsiveness of cerebellar granule cells at a mature developmental stage. Calretinin-deficient granule cells exhibit faster action potentials and generate repetitive spike discharge showing an enhanced frequency increase with injected currents. These alterations disappear when 0.15 mm of the exogenous fast-calcium buffer BAPTA is infused in the cytosol to restore the calcium-buffering capacity. A proposed mathematical model demonstrates that the observed alterations of granule cell excitability can be explained by a decreased cytosolic calcium-buffering capacity resulting from the absence of calretinin. This result suggests that calcium-binding proteins modulate intrinsic neuronal excitability and may therefore play a role in information processing in the CNS [less ▲]

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See detailL’herpèsvirus bovin 4
Markine-Goriaynoff, N.; Minner, F.; De Fays, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 215-247

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a ... [more ▼]

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a worldwide distribution in the cattle population. It has been isolated from cattle showing various clinical signs as well as from healthy cattle. The interest of the scientific community for BoHV-4 is explained by two reasons. Firstly, BoHV-4 represents an homologous virus/host species model to study the biology of gammaherpesviruses. Secondly, the use of BoHV-4 as a recombinant vector for expression both in vitro and in vivo has been proposed. For these reasons, a considerable amount of data has been collected on this virus. In the present paper, the authors will present a general overview of the literature published on this virus addressing clinical, epidemiological and fundamental aspects of BoHV-4. Finally, in the light of their recent phylogenetic data, the authors will discuss the origin and the host species of BoHV-4 leading to the conclusion that this virus should be considered as a virus of the African buffalo rather than cattle. [less ▲]

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See detailPour que le peuple lise : un siècle de lutte inachevée
Francis, Frédéric ULg

in Les Cahiers d’Education permanente (2003), 19

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See detailFlow cytometric cerebrospinal fluid analysis in children
Häusler, M.; Sellhaus, B.; Schweizer, K. et al

in Pathology Research and Practice (2003), 199(10), 667-675

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume ... [more ▼]

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume, surface antigen expression) even in small amounts of cells. Data on CSF FC in children are very limited. Here, we summarize our 3-year experience of CSF FC routinely performed in pediatric patients with assumed inflammatory central nervous system (CNS) disease. Among 109 samples sent for analysis, flow cytometric detection of major leukocyte subsets was possible in 78% (85 out of 109), which exceeds the 31% rate of our retrospective microscopic pediatric control group. Apart from physiologic lymphocytes (100%) or monocytes (48%), 11 out of these 85 samples showed granulocytes, two showed proliferated monocytes, and nine displayed proliferated lymphocytes. In most children, the proliferated lymphocytes consisted of a polyclonal population of CD4+ and CD8+ T cells. Compared with literature data, eight children showed abnormally composed lymphocyte subsets (surface antigen expression) within the main lymphocyte population. However, none of these changes was specific for distinct diseases or allowed a distinction between patients with and without primary inflammatory processes. These data suggest that CSF FC may be the most effective modality to differentiate major CSF leukocyte subsets. At present, further differentiation of distinct cell populations, such as proliferated lymphocytes, is of limited clinical impact. This may, however, gain increasing interest in the future. [less ▲]

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See detailReich-Ranicki und die ‚Erotik'. In: Das Internet-Portal Marcel Reich-Ranicki
Pontzen, Alexandra ULg

in Literaturkritik.de (2003)

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See detaille monument à Léopold Ier: aux origines de l'urbanisation de Laeken
Houbart, Claudine ULg

in Notre Comté. Annales du cercle d'histoire, d'archéologie et de folklore du comté de Jette et de sa région (2003), XXX

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See detailNéron et la magie
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (2003), 62

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See detailThe Mamluk Documents of the Venetian State Archives : Handlist
Bauden, Frédéric ULg

in Quaderni di Studi Arabi (2003), 20-21

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See detailExpression In A Rabgap Yeast Mutant Of Two Human Homologues, One Of Which Is An Oncogene
Bizimungu, C.; De Neve, N.; Burny, A. et al

in Biochemical and Biophysical Research Communications (2003), 310(2),

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See detailAccuracy of the continuous glucose monitoring system in inpatient and outpatient conditions
Djakouré-Platonoff, C.; RADERMECKER, Régis ULg; Reach, G. et al

in Diabètes & Métabolism (2003), 29

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See detailCompte rendu de Reliques et châsses de la collégiale de Soignies
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2003)

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See detailRétention gazeuse dans une colonne à bulles contenant un liquide visqueux non-newtonien
Fransolet, Emmanuelle; Coumont, V.; Crine, Michel ULg et al

in Tribune de l'Eau (La) (2003), 56(622), 15-20

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See detailL'éloge de la folie en hôpital de jour: présent du passé et perspectives
Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2003)

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See detailRooting blockage in the tobacco rac mutant occurs at the initiation phase, and induces diversion to xylem differentiation
Faivre-Rampant, Odile; D'Angeli, S.; Falasca, G. et al

in Plant Biosystems (2003), 137(2), 163-174

The rac mutant of Nicotiana tabacum L. cv. Xanthii is impaired in adventitious root formation. The objective of the present study was to determine whether or not the root induction phase occurs in the rac ... [more ▼]

The rac mutant of Nicotiana tabacum L. cv. Xanthii is impaired in adventitious root formation. The objective of the present study was to determine whether or not the root induction phase occurs in the rac mutant, and if so, to determine what causes the induced cells to become incapable of organising root primordia. To this end, rac and wild-type shoots were cultured in vitro for 7 days under conditions suitable for obtaining roots in the wild-type (i.e., exposure to 5 muM indole-3-butyric acid for 4 h, and then transfer to hormone-free medium), and then histologically and biochemically analysed during culture. The variations in peroxidase activity, and in cellular levels of auxins and polyamines revealed that the induction phase occurs in rac shoots, although it lasts longer than in the wild-type ones. Furthermore, both auxin and polyamines were consistently higher in rac shoots compared to the wild-type. After induction, auxin and putrescine levels abruptly decreased in the wild-type shoots, whereas they decreased much more slowly in the rac mutant. The histological analysis of the wild-type shoots showed that the abrupt decrease in auxin and polyamine levels were correlated with a normal initiation phase. In fact, wild-type shoots showed cell divisions in the procambium already at day 2, resulting in the formation of root primordia at day 4, and in root emergence between days 5 and 7. In rac shoots, despite the fact that the procambium cells were activated to undergo cell division, the initiation phase was highly perturbed, and the procambial cells developed tracheary elements instead of adventitious roots. The different morphogenic responses of the two genotypes are discussed in the light of the differences in auxin content after the induction phase. [less ▲]

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See detailReactive oxygen species downregulate the expression of pro-inflammatory genes by human chondrocytes.
Mathy, Marianne ULg; Martin, G.; Devel, P. et al

in Inflammation Research (2003), 52(3), 111-8

OBJECTIVES: To determine the regulatory effects of reactive oxygen species (ROS) on the expression by human osteoarthritic chondrocytes of interleukin (IL)-1beta, -6 and -8, inducible nitric oxide ... [more ▼]

OBJECTIVES: To determine the regulatory effects of reactive oxygen species (ROS) on the expression by human osteoarthritic chondrocytes of interleukin (IL)-1beta, -6 and -8, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene in response to interleukin (IL)-1beta or lipopolysaccharide (LPS). METHODS: Human chondrocytes in monolayer culture were incubated for 3 h with ROS generating molecules such as S-nitroso-N-acetyl-D,L-penicillamine (SNAP, 100 microM), 3-morpholinosydnonimine (SIN-1, 100 microM), with chemically synthesised peroxynitrite (ONOO-, 10 microM) or hydrogen peroxide (H2O2, 100 microM). After treatment by ROS, chondrocytes were washed and then cultured for the next 24 h with or without lipopolysaccharide LPS (10 microg/ml) or IL-1beta (1.10(-11) M). IL-1beta, IL-6, IL-8, iNOS and COX-2 gene expression was analysed by real time and quantitative RT PCR. IL-6, IL-8 and prostaglandin (PG) E2 productions were assayed by specific immunoassays. Nitrite was measured in the culture supernatants by the Griess procedure. RESULTS: LPS and IL-1beta stimulated IL-1beta, IL-6, IL-8, iNOS and COX-2 gene expression. SNAP significantly downregulated LPS induced overall gene expressions, whereas SIN-1 had no effect. ONOO- inhibited iNOS and COX-2 gene expression but not that of the cytokine genes. When chondrocytes were incubated with IL-1beta, SIN-1 and ONOO dramatically decreased all gene expressions while SNAP was inefficient. H2O2 treatment inhibited both LPS and IL-1beta induced gene expressions. CONCLUSIONS: These data provide an evidence that ROS may have anti-inflammatory properties by depressing inflammatory gene expression. Further, we demonstrate that ROS effects are dependent on the nature of radical species and the signalling pathway that is activated. These findings should be taken into consideration for the management of antioxidant therapy in treatment of inflammatory joint diseases. [less ▲]

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See detailThe impact of reimbursement criteria on the appropriateness of 'statin' prescribing.
Autier, Philippe; Creplet, Jean; Vansant, Greet et al

in European Journal of Cardiovascular Prevention & Rehabilitation (2003), 10(6), 456-62

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated ... [more ▼]

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated the possible impact of these regulations on characteristics of Belgian patients receiving a lipid-lowering drug. DESIGN: From 1998 to 2000, standard questionnaires on coronary risk factors and treatments with lipid-lowering drugs were completed by 301 GPs sampled at random in the 11 Belgian Provinces. Questionnaires had to be completed for 18 consecutive patients 35 years old or more attending GPs' practices, irrespective of the underlying motive for attendance. RESULTS: Of the 5511 patients included in the study, 1519 (28%) had established coronary disease or diabetes mellitus, or > or = 2 non-cholesterol coronary risk factors. Most (70%) of these patients were not treated with a lipid-lowering drug. Only 22% of patients with established coronary disease, 10% of patients with diabetes mellitus and 9% of patients with > or = 2 coronary risk factors were treated with a statin. Fifty-nine percent of fibrate users and 50% of statin users had a pre-treatment cholesterol level above 250 mg/dl, but had no or only one non-cholesterol coronary risk factor. CONCLUSIONS: In Belgium, the majority of patients at higher risk of coronary event do not benefit from lipid-lowering drugs, particularly the statins. In contrast, one of two statin users and three of five fibrate users should probably not receive the drug prescribed. Regulation based on blood cholesterol level encourages the overlooking of other risk factors relevant for selecting patients having the greatest chance to benefit from statin treatment. [less ▲]

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See detailRole of catalase in ethanol-induced conditioned taste aversion : a study with 3-amino-1,2,4-triazole
Quertemont, Etienne ULg; Escarabajal, M. Dolores; De Witte, Philippe

in Drug and Alcohol Dependence (2003), 70(1), 77-83

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain ... [more ▼]

Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain metabolism of ethanol by the enzyme catalase. Therefore, the inhibition of catalase by 3-amino-1,2,4-triazole (aminotriazole) may help to clarify the involvement of acetaldehyde in ethanol's hedonic effects. In the present study, multiple doses of both ethanol and aminotriazole were used to investigate the effects of catalase inhibition on ethanol-induced conditioned taste aversion (CTA). A separate microdialysis experiment investigated the effects of aminotriazole pretreatment on the time course of brain ethanol concentrations. Ethanol induced a dose-dependent CTA with a maximal effect after conditioning with 2.0 g/kg ethanol. Aminotriazole pretreatments dose-dependently potentiated the CTA induced by 1.0 g/kg ethanol. However, aminotriazole pretreatments did not alter the CTA induced by higher ethanol doses (1.5 and 2.0 g/kg) probably because a maximal aversion for saccharin was already obtained without aminotriazole. The results of the microdialysis experiment confirmed that the effects of aminotriazole cannot be attributed to local alterations of brain ethanol levels. The present study argues against a role for brain acetaldehyde in ethanol's aversive effects but in favor of its involvement in ethanol rewarding properties. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailMathematical modelling and design of an advanced once-through heat recovery steam generator
Dumont, Marie-Noëlle ULg; Heyen, Georges ULg

in Computer Aided Chemical Engineering (2003), 14

The once-through heat recovery steam generator design is ideally matched to very high temperature and pressure, well into the supercritical range. Moreover this type of previous termboilernext term is ... [more ▼]

The once-through heat recovery steam generator design is ideally matched to very high temperature and pressure, well into the supercritical range. Moreover this type of previous termboilernext term is structurally simpler than a conventional one, since no drum is required. A specific mathematical model has been developed. Thermodynamic model has been implemented to suit very high pressure (up to 240 bar), sub- and supercritical steam properties. We illustrate the model use with a 180 bar once-through previous termboilernext term (OTB). [less ▲]

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See detailRuthenium catalysts bearing N-heterocyclic carbene ligands in atom transfer radical reactions
Richel, Aurore ULg; Delfosse, Sébastien ULg; Cremasco, Cédric et al

in Tetrahedron Letters (2003), 44(32), 6011-6015

The catalytic activity of ruthenium-p-cymene complexes bearing N-heterocyclic carbene ligands in atom transfer radical addition (ATRA) or polymerisation (ATRP) strongly depends on the substituents of the ... [more ▼]

The catalytic activity of ruthenium-p-cymene complexes bearing N-heterocyclic carbene ligands in atom transfer radical addition (ATRA) or polymerisation (ATRP) strongly depends on the substituents of the carbene ligand, thereby providing a nice illustration of the importance of organometallic engineering and ligand fine tuning in homogeneous catalysis. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailOn the exploitation of chaos to build reduced-order models
Kerschen, Gaëtan ULg; Feeny, B. F.; Golinval, Jean-Claude ULg

in Computer Methods in Applied Mechanics & Engineering (2003), 192(13-14), 1785-1795

The present study focuses on the model reduction of non-linear systems. The proper orthogonal decomposition is exploited to compute eigenmodes from time series of displacement. These eigenmodes, called ... [more ▼]

The present study focuses on the model reduction of non-linear systems. The proper orthogonal decomposition is exploited to compute eigenmodes from time series of displacement. These eigenmodes, called the proper orthogonal modes, are optimal with respect to energy content and are used to build a low-dimensional model of the non-linear system. For this purpose, the proper orthogonal modes obtained from a chaotic orbit are considered. Indeed, such an orbit is assumed to cover a portion of the phase space of higher dimension, and hence of greater measure. This higher dimensional data is further assumed to contain more information about the system dynamics than data of a lower-dimensional periodic orbit. In an example, it is shown that the modes for this particular behaviour are more representative of the system dynamics than any other set of modes extracted from a non-chaotic response. This is applied to a buckled beam with two permanent magnets and the reduced-order model is validated using both qualitative and quantitative comparisons. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailIdentification On Commercialized Products Of Aflp Markers Able To Discriminate Slow- From Fast-Growing Chicken Strains
Fumiere, Olivier; Dubois, Marc; Gregoire, Dimitrie et al

in Journal of Agricultural and Food Chemistry (2003), 51(5), 1115-1119

The European chicken meat market is characterized by numerous quality marks: “Label de Qualité Wallon” in Belgium, “Label Rouge” in France, denominations of geographical origin, organic agriculture, etc ... [more ▼]

The European chicken meat market is characterized by numerous quality marks: “Label de Qualité Wallon” in Belgium, “Label Rouge” in France, denominations of geographical origin, organic agriculture, etc. Most of those certified productions have specifications requiring the use of slow-growing chicken strains. The amplified fragment length polymorphism (AFLP) technique has been used to search molecular markers able to discriminate slow-growing chicken strains from fast-growing ones and to authenticate certified products. Two pairs of restriction enzymes (EcoRI/MseI and EcoRI/TaqI) and 121 selective primer combinations were tested on individual DNA samples from chicken products essentially in carcass form that were ascribed as belonging to either slow- or fast-growing strains. Within the resulting fingerprints, two fragments were identified as type−strains specific markers. One primer combination gives a band (333 bp) that is specific for slow-growing chickens, and another primer pair generates a band (372 bp) that was found to be characteristic of fast-growing chickens. The two markers were isolated, cloned, and sequenced. The effectiveness and the specificity of the two interesting determinants were assessed on individuals of two well-known strains (ISA 657 and Cobb 500) and on commercialized products coming from various origins. [less ▲]

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See detailHow do paedomorphic newts cope with lake drying?
Denoël, Mathieu ULg

in Ecography (2003), 26(4), 405-410

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic ... [more ▼]

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic habitats surrounded by hostile terrestrial environments. Nevertheless, numerous ponds inhabited by paedomorphic individuals are unpredictable and temporary. In an experimental framework, I showed that paedomorphic newts were able to metamorphose and thus survive in the absence of water. However, the mere decrease of water level or the life space do not seem to induce metamorphosis in paedomorphs. On the contrary, drying up induces almost all individuals to move on land and after that to colonize other aquatic sites located nearby. Such terrestrial migrations allow survival in drying conditions without metamorphosis as long as the distances of terrestrial migration are short. These results are consistent with the presence of paedomorphs in drying ponds and are in favor of classic optimality models predicting metamorphosis in unfavorable environments. [less ▲]

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See detailMinitransplants: allogeneic stem cell transplantation with reduced toxicity.
Beguin, Yves ULg; Baron, Frédéric ULg

in Acta Clinica Belgica (2003), 58(1), 37-45

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the conditioning regimen and the graft-versus-host reactions, respectively. The high-dose chemo-radiotherapy conditioning regimen is aimed at destroying tumor cells, ablating the host immune system (to prevent rejection) and eliminating the host bone marrow (to "make space" for donor stem cells). However, the definitive eradication of tumor cells is also largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger (< 55 years) and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols based on a two step approach: first the use of immunosuppressive (but nonmyeloablative) conditioning regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. These transplants are called nonmyeloablative HSCT or reduced-conditioning HSCT or minitransplants. Preliminary results show that minitransplants are feasible with a relatively low transplant-related mortality (TRM) even in patients up to 70 years. In addition, strong anti-tumor responses are observed in several hematological malignancies as well as in some patients with renal cell carcinoma. As the benefits of minitransplants over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

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See detailCensure et stéréotype. Structures du sens commun journalistique
Durand, Pascal ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2003), 97-99

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See detailThe Acyclic Nucleoside Phosphonate Analogues, Adefovir, Tenofovir And Pmedap, Efficiently Eliminate Banana Streak Virus From Banana (Musa Spp.)
Helliot, B.; Panis, B.; Frison, E. et al

in Antiviral Research (2003), 59(2), 121-126

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See detail1s2s2p(2)3s 6P - 1s2p(3)3s 6S° transitions in OIV
Lin, B.; Berry, H. G.; Shibata, T. et al

in Physical Review. A (2003), 67

The energies and lifetimes of doubly excited sextet states of boron-like O IV, F V, and Ne VI are calculated with the multiconfiguration Hartree-Fock approach, including QED and higher-order corrections ... [more ▼]

The energies and lifetimes of doubly excited sextet states of boron-like O IV, F V, and Ne VI are calculated with the multiconfiguration Hartree-Fock approach, including QED and higher-order corrections, and also with the multiconfiguration Dirac-Fock GRASP code. The wavelengths and transition rates of electric-dipole transitions from the inner-shell excited terms 1s2s2p23s 6P–1s2p33s 6So are investigated by beam-foil spectroscopy in the XUV spectral region. The predicted transition wavelengths agree with the experiment. The higherorder corrections, fine structures, and spectrum with high wavelength resolution are found to be critically important in these comparisons. Nine new lines have been identified. The ground sextet states of boronlike atoms are metastable and well above several ionization levels. These are possible candidates for XUV and soft x-ray lasers. [less ▲]

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See detailAstronomes célèbres et astronomes moins connus ... (1) William Herschel
Biémont, Emile ULg

in Galactée (2003), 34

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See detailField-dependent vortex pinning strength in a periodic array of antidots
Silhanek, Alejandro ULg; Raedts, S.; Lange et al

in Physical Review. B : Condensed Matter (2003), 67(6),

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime ... [more ▼]

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime, vortex motion is of intravalley type and the penetration depth is related to the curvature of the pinning potential well alpha. For dc fields below the first matching field H-1, alpha reaches its highest value associated with a Mott insulator like phase where vortex lines are strongly localized at the pinning sites. For H-1<H-dc<H-2, the response is mainly due to the interstitial vortices and α drops to smaller values as expected for this metallic like regime. Strikingly, for H-2<H-dc<H-3, we observe that α reduces further down. However, for H-3<H-dc<H-4, a reentrance in the pinning strength is observed, due to a specific configuration of the flux-line lattice which strongly restricts the mobility of vortices. We present a possible explanation for the measured α(H-dc) dependence based on the different flux-line lattice configurations. [less ▲]

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See detailAstronomes célèbres et astronomes moins connus ... (3) Hipparque
Biémont, Emile ULg

in Galactée (2003), 35

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See detailC.R. de La Chanson de Croissant en prose du XVe siècle (éd. M. Raby)
Henrard, Nadine ULg

in Moyen Age (Le) (2003), CIX(3-4), 665-668

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See detailAstronomes célèbres et astronomes moins connus ... (2) Les Cassini
Biémont, Emile ULg

in Galactée (2003), 35

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See detailPropriétés des merrains affinés dans une solution d’enzymes naturels et destinés à la tonnellerie
Jourez, Benoît ULg; Charron, Stéphane; Hebert, Jacques ULg

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60

Properties of shooks ageing by a treatment in a solution of natural enzymes. A speeding up of the ageing of shooks is possible by a treatment with a solution of natural enzymes. However its repercussion ... [more ▼]

Properties of shooks ageing by a treatment in a solution of natural enzymes. A speeding up of the ageing of shooks is possible by a treatment with a solution of natural enzymes. However its repercussion on physical, mechanical characteristics of wood and on its absorption potential of an hydro-alcoholic solution must be tested. Normalized samples have been extracted from 150 shooks selected on a ring width criteria from three cooperages located on different supplying area in France. The three factors cooperage, ring width class and treatment are used for statistical analysis. The cooperage factor, reflection of the supply area of each of them, affect the young modulus and the modulus of rupture in static bending but not the other characteristics. The improvement of the wood properties is closely linked to the ring width increaseof the samples. The enzymatic treatment has no significant effect on physical and mechanical characteristics of oak wood, except on the hardness and, to a lesser extent, on the absorption potential. Considering the absence of negative effect on characteristics of shooks and the positive contribution of enzymatic treatment on their ageing, this treatment could bring a very interesting economical alternative permitting to avoid long lasting storage of the shooks before assembly. [less ▲]

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See detailNéoplasie endocrinienne multiple de type 1 : De la clinique au gène
Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg; Vanbellinghen, Jean-François ULg et al

in Feuillets de Biologie (2003), 44(250), 39-48

La Néoplasie Endocrinienne Multiple de type 1 (NEM 1), syndrome génétique à transmission autosomique dominante, est caractérisée principalement par l'atteinte des parathyroïdes, du tractus gastro-entéro ... [more ▼]

La Néoplasie Endocrinienne Multiple de type 1 (NEM 1), syndrome génétique à transmission autosomique dominante, est caractérisée principalement par l'atteinte des parathyroïdes, du tractus gastro-entéro-pancréatique et de l'antéhypophyse. Les manifestations cliniques de ce syndrome sont polymorphes. En fonction de l'organe affecté elles peuvent se manifester par l'hypersécrétion hormonale, par un syndrome de masse dû à la taille tumorale, ou parfois par l'apparition d'un cancer. Le gène responsable de la NEM 1 a été identifié sur le chromosome 11, locus 11q13. Il s'agit d'un gène supresseur de tumeur qui code pour une protéine dénommée ménine. Dans cet article nous aborderons les aspects cliniques et génétiques typiques de cette affection. [less ▲]

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