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See detailA dip into the world of veterinary nuclear medicine: equine lung scintigraphy
Votion, Dominique ULg; Lekeux, Pierre ULg

in Clinical Techniques in Equine Practice (2003), 2(3), 222-230

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology ... [more ▼]

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology, for the knowledge of animal peculiarities, for the study and diagnosis of equine respiratory disorders as well as for the development of their treatment. This article surveys some methodological constraints due to the scanning of a noncooperative large-sized animal, reviews the contribution of equine nuclear imaging in lung physiology and pathology, and discusses future clinical and fundamental applications of lung scintigraphy. [less ▲]

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See detailDelayed onset muscle soreness induced by eccentric isokinetic exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Forthomme, Bénédicte ULg et al

in Isokinetics & Exercise Science (2003), 11(1), 21-29

Delayed onset muscle soreness (DOMS) follows unaccustomed muscular exercise, most notably in the eccentric mode. That concept refers to a dull ache combined with tenderness, stiffness and weakness of the ... [more ▼]

Delayed onset muscle soreness (DOMS) follows unaccustomed muscular exercise, most notably in the eccentric mode. That concept refers to a dull ache combined with tenderness, stiffness and weakness of the previously active muscles. lsokinetic device constitutes a specific model in generating and investigating DOMS. Respective effects of concentric and eccentric actions have been compared, emphasizing on the variability in the response (serum activity of CK for instance). The particular sensitivity of the hamstrings was underlined although causes remained unexplained. Some treatment have been proposed in the management of DOMS. Several studies reported that anti-inflammatory agents fail to alleviate pain and discomfort even if other authors indicated a relative effectiveness. Based on the repeated-bout effect, submaximal eccentric exercise currently represent the most useful preventive strategy. [less ▲]

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See detailPathophysiology of type 2 diabetes.
Scheen, André ULg

in Acta Clinica Belgica (2003), 58(6), 335-41

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and ... [more ▼]

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions of beta-cell dysfunction and reduced insulin sensitivity to the pathogenesis of diabetes, it is generally agreed that both these factors play important roles. However, the mechanisms controlling the interplay of these two impairments are unclear. A number of factors have been suggested as possibly linking insulin resistance and beta-cell dysfunction in the pathogenesis of type 2 diabetes. A majority of individuals suffering from type 2 diabetes are obese, with central visceral adiposity. Therefore, the adipose tissue should play a crucial role in the pathogenesis of type 2 diabetes. Although the predominant paradigm used to explain this link is the portal/visceral hypothesis giving a key role in elevated non-esterified fatty acid concentrations, two new emerging paradigms are the ectopic fat storage syndrome (deposition of triglycerides in muscle, liver and pancreatic cells) and the adipose tissue as endocrine organ hypothesis (secretion of various adipocytokins, i.e. leptin, TNF-alpha, resistin, adiponectin, implicated in insulin resistance and possibly beta-cell dysfunction). These two paradigms constitute the framework for the study of the interplay between insulin resistance and beta-cell dysfunction in type 2 diabetes as well as between our obesogenic environment and diabetes risk in the next decade. [less ▲]

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See detailBasalt weathering laws and the impact of basalt weathering on the global carbon cycle
Dessert, C.; Dupre, B.; Gaillardet, J. et al

in Chemical Geology (2003), 202(3-4), 257-273

This study attempts to characterise the chemical weathering of basalts and to quantify the flux of carbon transferred from the atmosphere to the ocean during this major process at the surface of the Earth ... [more ▼]

This study attempts to characterise the chemical weathering of basalts and to quantify the flux of carbon transferred from the atmosphere to the ocean during this major process at the surface of the Earth. To this aim, we have compiled different published chemical compositions of small rivers draining basalts. Basaltic river waters are characterised by relatively high Na-normalized molar ratios (Ca/Na: 0.2-3.9; HCO3/Na: 1-10; Mg/Na: 0.15-6) in comparison with those usually observed for river draining silicates. The data also show the climatic influence on basalt weathering and associated CO2 consumption. Runoff and temperature are the main parameters controlling the chemical weathering rate and derived CO2 consumption during basaltic weathering. From these relationships and digital maps, we are able to define the contribution of basalts to the global silicate flux. Taking account of this result, we estimate that the CO2 flux consumed by chemical weathering of basalts is about 4.08 x 10(12) mol/year. The fluxes from the islands of Indonesia and regions of central America represent around 40% of this flux. The global flux of CO2 consumed by chemical weathering of basalts represents between 30% and 35% of the flux derived from continental silicate determined by Gaillardet et al. [Chem. Geol. 159 (1999) 3]. Finally, it appears that volcanic activity not only acts as a major atmospheric CO2 source, but also creates strong CO2 sinks that cannot be neglected to better understand the geochemical and climatic evolution of the Earth. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailLa loi du 11 mai 2003 relative à la recherche sur les embryons in vitro
Leleu, Yves-Henri ULg

in Revue Trimestrielle de Droit Familial (2003)

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See detailSymetrie et reproductibilite temporelle des donnees neurographiques.
Bouquiaux, Olivier ULg; Horward, A.; Wang, François-Charles ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2003), 33(4), 185-95

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected ... [more ▼]

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected from 30 healthy subjects (mean age 22 +/- 2 years). METHODS: The protocol at T1 consisted of motor nerve conduction studies of median, ulnar, peroneal and tibial nerves bilaterally, with measurement of (a) motor response size (amplitude and area); (b) terminal latency; (c) minimal, mean and maximal F-wave latency; (d) motor conduction velocity; and (e) F-wave occurrence. T1 also involved sensory nerve conduction studies of median, ulnar, radial, lateral and medial cutaneous, sural and superficial peroneal nerves bilaterally, with measurement of sensory potential size (amplitude and area) and computation of sensory conduction velocity. The protocol at T2 consisted of identical measurements from the dominant side. RESULTS AND CONCLUSION: There was a negative relationship between the variability of parameters evaluating nervous conduction and the length of the nerve segment under study. Thus, the smallest side-to-side and temporal variabilities are measured for minimal F-wave latencies (on average 2-3%). The limits of symmetry and temporal variability are particularly useful for diagnosis of unilateral peripheral neuropathy or neurophysiological follow-up of patients with neuropathy, when the variability of the parameter under study is weak and when there is a high correlation between values recorded on the left and on the right or at T1 and T2. This was the case for motor response size of tibial and ulnar nerves, sensory potential size of radial nerve and minimal F-wave latencies from each studied motor nerve. [less ▲]

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See detailA time–frequency technique for the stability analysis of impulse responses from nonlinear aeroelastic systems
Dimitriadis, Grigorios ULg; Cooper, Jonathan E

in Journal of Fluids & Structures (2003), 17(8), 11811201

A time–frequency method is proposed for the analysis of response time histories from nonlinear aeroelastic systems. The approach is based on a time-varying curve-fit of the short time Fourier transform of ... [more ▼]

A time–frequency method is proposed for the analysis of response time histories from nonlinear aeroelastic systems. The approach is based on a time-varying curve-fit of the short time Fourier transform of the impulse response. It is shown that the method can be used in order to obtain a clear picture of the sub-critical stability of a number of aeroelastic systems with a variety of structural and aerodynamic nonlinearities. Additionally, frequency and amplitude information can be obtained for both the linear and nonlinear signatures of the response signals in the sub- and postcritical regions. Finally, it is shown that, given certain types of nonlinear functions, sub-critical damping trends can be extrapolated to predict bifurcation airspeeds. [less ▲]

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See detailInvestigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry
Pochet, L.; Dieu, M.; Frederick, R. et al

in Tetrahedron (2003)

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See detailLes onychomycoses--echec et mat?
Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2003), 58(9), 559-62

According to individuals, onychomycoses or their treatments can be held in check. Some of the "promises" sometimes offered by pharmaceutical companies are not fully kept and hopes of cure may remain wild ... [more ▼]

According to individuals, onychomycoses or their treatments can be held in check. Some of the "promises" sometimes offered by pharmaceutical companies are not fully kept and hopes of cure may remain wild. Some special therapeutic strategies should be employed in case of recalcitrant or recurrent onychomycosis. [less ▲]

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See detailLa critique de la perception interne de Brentano à Heidegger
Seron, Denis ULg

in Etudes Phénoménologiques (2003), 37-38

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See detailLe Gigantisme : Un mystère élucidé
Beckers, Albert ULg

in Revue Roumaine d'Endocrinologie (2003), 2(4), 88-9394-97

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See detailThe new concept-temporary stents, an experimental study.
Kavteladze, Z. A.; Dundua, D. P.; Dondelinger, R. F. et al

in International Journal of Interventional Cardioangiology (2003), 1

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See detailNudging epidermal field cancerogenesis by imiquimod.
Uhoda, Isabelle; Quatresooz, Pascale ULg; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 357-60

BACKGROUND: The coexistence of malignancies close to each other on the skin has been occasionally reported. The concept of field cancerogenesis applies to such cases. Given the purported mechanism of ... [more ▼]

BACKGROUND: The coexistence of malignancies close to each other on the skin has been occasionally reported. The concept of field cancerogenesis applies to such cases. Given the purported mechanism of action of imiquimod, it should not be surprising that this treatment could inhibit epidermal field cancerogenesis. AIM: To assess the effect of imiquimod applied twice weekly on incipient bowenoid changes disclosed in the vicinity of basal cell carcinomas. MATERIALS AND METHOD: Biopsies were taken before treatment and after 4-6 weeks and 12 weeks of imiquimod treatment. RESULTS: Large atypical bowenoid keratinocytes and dyskeratotic cells were cleared in time while factor-XIIIa-positive dermal dendrocytes appeared boosted and admixed with a brisk lymphocytic infiltration. CONCLUSION: Epidermal field cancerogenesis appears to be controlled by imiquimod. Dermal dendrocytes might play a pivotal role in this regression phenomenon. [less ▲]

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See detailUn cas peu connu de traduction du grec en latin : l'Asclepius du Corpus Hermeticum
Rochette, Bruno ULg

in Cahiers du Centre Gustave Glotz (2003), 14

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See detailWithin-herd effects of age at test day and lactation stage on test-day yields
Bormann, J.; Wiggans, G. R.; Druet, Tom ULg et al

in Journal of Dairy Science (2003), 86(11), 3765-3774

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve ... [more ▼]

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve the accuracy of estimation. Test-day data starting with 1990 calvings for the entire US Jersey population and Holsteins from California, Pennsylvania, Wisconsin, and Texas were analyzed. Test-day yields were adjusted for across-herd effects using solutions from a regional analysis. Estimates of the relative variance ( fraction of total variance) due to within-herd age effects were small, indicating that regional adjustments for age were adequate. The relative variances for within-herd lactation stage were large enough to indicate that accuracy of genetic evaluations could be improved by including herd stage effects in the model for milk, fat, and protein, but not for somatic cell score. Because the within-herd lactation stage effect is assumed to be random, the effect is regressed toward the regional effects for small herds, but in large herds, lactation curves become herd specific. Model comparisons demonstrated the greater explanatory power of the model with a within-herd-stage effect as prediction error standard deviations were greater for the model without this effect. The benefit of the within-herd-stage effects was confirmed in a random regression model by comparing variance components from models with and without random within-herd regressions and through log-likelihood ratio tests. [less ▲]

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See detailOn Iterating Linear Transformations over Recognizable Sets of Integers
Boigelot, Bernard ULg

in Theoretical Computer Science (2003), 309(1-3), 413-468

It has been known for a long time that the sets of integer vectors that are recognizable by finite-state automata are those that can be defined in an extension of Presburger arithmetic. In this paper, we ... [more ▼]

It has been known for a long time that the sets of integer vectors that are recognizable by finite-state automata are those that can be defined in an extension of Presburger arithmetic. In this paper, we address the problem of deciding whether the closure of a linear transformation preserves the recognizable nature of sets of integer vectors. We solve this problem by introducing an original extension of the concept of recognizability to sets of vectors with complex components. This generalization allows to obtain a simple necessary and sufficient condition over linear transformations, in terms of the eigenvalues of the transformation matrix. We then show that these eigenvalues do not need to be computed explicitly in order to evaluate the condition, and we give a full decision procedure based on simple integer arithmetic. The proof of this result is constructive, and can be turned into an algorithm for applying the closure of a linear transformation that satisfies the condition to a finite-state representation of a set. Finally, we show that the necessary and sufficient condition that we have obtained can straightforwardly be turned into a sufficient condition for linear transformations with linear guards. [less ▲]

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See detailChorionic expression of heterogeneous products of the PAG (Pregnancy-Associated Glycoprotein) gene family secreted in vitro throughout embryonic and foetal development in the pig
Szafranska, B.; Panasiewicz, G.; Majewska, M. et al

in Reproduction Nutrition Development (2003), 43(6), 497-516

Porcine PAG (pPAG) are placental products of a multigene family that is strongly expressed in the chorionic epithelium (trophoblast and trophectoderm). The objective of this study was to define a pattern ... [more ▼]

Porcine PAG (pPAG) are placental products of a multigene family that is strongly expressed in the chorionic epithelium (trophoblast and trophectoderm). The objective of this study was to define a pattern of the pPAG proteins, secreted in vitro by chorionic explants harvested on 16-77 days of pregnancy. Trophoblastic and trophectodermal explants were collected from pregnant (PR) gilts (n = 27) and used for protein in vitro production (8-261 h). Endometrial explants of luteal-phase gilts (E10, n = 4) and pseudopregnant gilts (PsE, n = 2) were used as negative controls for protein immunoblotting. Proteins (PR, E10, PsE) were isolated mainly from incubation media, fractionated, dialysed and separated by SDS-PAGE. Heterogeneous Western blotting with various polyclonal anti-PAG sera raised against bovine or ovine antigens (anti-bPAG, or anti-oPAG) initially identified the pPAG proteins. Such blotting of fractionated chorionic proteins allowed for the isolation of porcine antigens that were employed as immunogens to raise several homologous antisera (anti-pPAG). Crude antisera were adsorbed on endometrial extracts or proteins of non-PR pigs, to remove non-relevant antibodies. The patterns of pPAG proteins secreted in Vitro varied throughout pregnancy (35-72 kDa). During implantation, similar to43 kDa (Day 16) or similar to68.1 kDa (Days 17-25) pPAG proteins were detected. During placentation and as pregnancy advanced (Days 31-77), similar to72.3 kDa pPAG proteins were observed. The secretions of parallel multiple smaller proteins (35.4-47.2 kDa), presumably, as forms of processed pPAG precursors, increased with the progress of gestation. In conclusion, the pPAG protein family plays a very important role during implantation, placenta formation and embryonic/foetal development in the pig. [less ▲]

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See detailSubocclusion colique precoce apres traitement d'une maladie de Crohn refractaire active par infliximab.
Belaiche, Jacques ULg; Louis, Edouard ULg

in Gastroentérologie Clinique et Biologique (2003), 27(11), 1045-7

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See detailInsertion Of X-Ray Structures Of Proteins In Membranes
Basyn, F.; Spies, B.; Bouffioux, O. et al

in Journal of Molecular Graphics & Modelling (2003), 22(1), 11-21

Few structures of membrane proteins are known and their relationships with the membrane are unclear. In a previous report, 20 X-ray structures of transmembrane proteins were analyzed in silico for their ... [more ▼]

Few structures of membrane proteins are known and their relationships with the membrane are unclear. In a previous report, 20 X-ray structures of transmembrane proteins were analyzed in silico for their orientation in a 36A-thick membrane [J. Mol. Graph. Model. 20 (2001) 235]. In this paper, we use the same approach to analyze how the insertion of the X-ray structures varies with the bilayer thickness. The protein structures are kept constant and, at each membrane thickness, the protein is allowed to tilt and rotate in order to accommodate at their best. The conditions are said to be optimal when the energy of insertion is minimal. The results show that most helix bundles require thicker membranes than porin barrels. Moreover, in a few instances, the ideal membrane thickness is unrealistic with respect to natural membranes supporting that the X-ray structure requires adaptation to stabilize in membrane. For instance, the squalene cyclase could adapt by bending the side chains of its ring of lysine and arginine in order to increase the hydrophobic surface in contact with membranes. We analyzed the distribution of amino acids in the water, interface and acyl chain layers of the membrane and compared with the literature. [less ▲]

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See detailAn Integrated Software for Scantling Optimization and Least Production Cost
Rigo, Philippe ULg

in Ship Technology Research = Schiffstechnik (2003)

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See detailDevelopment and validation of a specific radioimmunoassay for equine osteocalcin
Carstanjen, Bianca; Sulon, Joseph ULg; Banga-Mboko, H. et al

in Domestic Animal Endocrinology (2003), 24(1), 31-41

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard ... [more ▼]

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard, tracer, and immunogen for antibody formation in rabbits. The assay allowed to measure equine serum OC levels with a sensitivity of 0.2 ng/mL. Immunoreactive serum OC values of clinically normal, different-aged horses ranged from 3.68 to 127.31 ng/mL. Intra- and inter-assay coefficients of variation (CV) were 6.2 and 8.2%, respectively. Serial equine scrum sample dilutions were linear. The recovery of equine OC from equine serum samples ranged from 93.88 to 107.9%. There was a tight correlation between OC values measured with the equine- specific OC RIA and two commercially available bovine-specific OC RIA kits. However, highest serum OC values were obtained with the equine-specific OC RIA. In conclusion, our equine-specific OC RIA is sensitive, linear, accurate, precise, and reproducible. The assay allowed to quantify OC in equine serum samples and might, therefore, be used to monitor equine osteoblast activity associated with bone diseases, exercise, therapy forms or diet. [less ▲]

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See detailIntegrated detection and correction of outliers in a random regression test-day model
Mayeres, Patrick; Gillon, Alain ULg; Gengler, Nicolas ULg

in INTERBULL Bulletin (2003), 31

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See detailFinancement du terrorisme
Dantinne, Michaël ULg; Seron, Vincent ULg

in Revue de Droit Pénal et de Criminologie (2003), (6), 840-875

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See detailEffect of pressure and temperature upon tin alkoxide-promoted ring-opening polymerisation of epsilon-caprolactone in supercritical carbon dioxide
Stassin, Fabrice; Jérôme, Robert ULg

in Chemical Communications (2003), (2), 232-233

Ring-opening polymerisation of epsilon-caprolactone in supercritical carbon dioxide is slowed down by a carbonation reaction, resulting in a positive volume of activation and a higher energy of activation ... [more ▼]

Ring-opening polymerisation of epsilon-caprolactone in supercritical carbon dioxide is slowed down by a carbonation reaction, resulting in a positive volume of activation and a higher energy of activation as compared to polymerisation in a regular hydrocarbon solvent. [less ▲]

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See detailOverexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype.
Oury, Cécile ULg; Kuijpers, Marijke; Toth-Zsamboki, Emese et al

in Blood (2003)

This study describes transgenic mice overexpressing the human P2X(1) ion channel in the megakaryocytic cell lineage. Platelets from these mice display increased secretion and aggregation evoked by low ... [more ▼]

This study describes transgenic mice overexpressing the human P2X(1) ion channel in the megakaryocytic cell lineage. Platelets from these mice display increased secretion and aggregation evoked by low doses of collagen, convulxin, or the thromboxane A(2) mimetic U46619. Perfusing whole blood from transgenic mice over collagen fibers at a shear rate of 1000 seconds(-1) resulted in increased P2X(1)-dependent aggregate formation and phosphatidylserine exposure. Platelet hyperreactivity to collagen was correlated with up-regulated extracellular signal-regulated kinase 2 (ERK2) phosphorylation. In a viscometer, shear stress caused potent aggregation of transgenic platelets under conditions in which wild-type platelets did not aggregate. In an in vivo model of thromboembolism consisting of intravenous injection of a low dose of collagen plus epinephrine, transgenic mice died more readily than wild-type mice. Preinjection of U0126 not only fully protected transgenic mice against thrombosis, it also enhanced the survival of wild-type mice injected with a higher collagen dose. Hence, the platelet P2X(1) ion channel plays a role in hemostasis and thrombosis through its participation in collagen-, thromboxane A(2)-, and shear stress-triggered platelet responses. Activation of the ERK2 pathway is instrumental in these processes. [less ▲]

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See detailChronique de la 55ème Session de la SIHDA à Rotterdam (18-22 Septembre 2001)
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (2003), L

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See detailEtudes des impacts hydrauliques, sédimentologiques et écologiques liés aux travaux hydrauliques sur la Semois
Gob, Frédéric; Houbrechts, Geoffrey ULg; Mols, Julien et al

in Belgeo (2003), 3

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux ... [more ▼]

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux, géomorphologiques et sédimentologiques. [less ▲]

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See detailConsequences of imperfect insulation - Numerical Modelling
Franssen, Jean-Marc ULg

in Journal of Fire Protection Engineering (2003), 18

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See detailSpline wavelets in periodic Sobolev spaces and application to high order collocation methods
Bastin, Françoise ULg; Boigelot, Christine; Laubin, Pascal

in Revista de la Union Matematica Argentina (2003), 44(1), 53-74

In this paper, we present a particular family of spline wavelets constructed from the Chui-Wang Riesz basis of $L^2(\mathbb{R})$. The construction is explicit, allowing the study of specific functional ... [more ▼]

In this paper, we present a particular family of spline wavelets constructed from the Chui-Wang Riesz basis of $L^2(\mathbb{R})$. The construction is explicit, allowing the study of specific functional properties and rather easy handling in numerical computations. This family constitutes a Riesz hierarchical basis in periodic Sobolev spaces. We also present a necessary and sufficient condition of strong ellipticity for pseudodifferential operators obtained with respect to these splines. It uses a new expression for the numerical symbol of the boundary integral operators. This expression allows us to use efficiently collocation methods with different meshes and splines. [less ▲]

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See detailDoes Export Controls Regimes could Contribute to Counter the Acquisition of WMD by Sub-national ?,
Michel, Quentin ULg

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Sciences (2003)

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See detailEstimating internal pelvic sizes using external body measurements in the double-muscled Belgian Blue beef breed
Coopman, F.; de Smet, S.; Gengler, Nicolas ULg et al

in Animal Science (2003), 76(Part 2), 229-235

In the double-muscled (DM) Belgian Blue beef (BBB) breed, caesarean section (CS) is being applied systematically as a management tool to prevent dystocia. As a matter of fact, CS is the only possible way ... [more ▼]

In the double-muscled (DM) Belgian Blue beef (BBB) breed, caesarean section (CS) is being applied systematically as a management tool to prevent dystocia. As a matter of fact, CS is the only possible way of calving in the breed. High birth weight and a relatively small pelvic area are the main causes of dystocia and, in the DM-BBB breed, the reasons for the systematically applied CS. Selection for lower birth weight and larger pelvic sizes might reduce dystocia and routine CS. Few data on inner pelvic sizes of pedigree animals are available. Using external measurements to estimate the inner pelvic sizes might be an option to resolve this problem. In this study, animals of the DM-BBB breed were measured and weighed on farms and in abattoirs. External and internal pelvic sizes increased with live weight and age of the animals. Gender had a significant influence on inner pelvic traits. Increased muscular conformation was associated with decreased inner pelvic dimensions. Models with weight, gender, age, withers height and outer pelvic width (TcTc) can be used to estimate inner pelvic sizes (R-2 between 0.35 and 0.77). The estimated inner pelvic sizes can then be used to genetically evaluate pelvic traits in the DM-BBB breed. Improving weight, withers height and TcTc width in combination with lowering muscular conformation may help to decrease the high rate of caesarean section in the DM-BBB. [less ▲]

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See detailAu delà de l’irrationalité : vers une psychologique du phénomène de harcèlement moral.
Geuzaine, Caroline; Faulx, Daniel ULg

in Cahiers Internationaux de Psychologie Sociale (2003), 48

De prime abord, les situations de harcèlement moral dégagent une impression d’irrationalité intense (Geuzaine & Faulx, 2000). Depuis notre position d’observateur extérieur, nous sommes face à un ensemble ... [more ▼]

De prime abord, les situations de harcèlement moral dégagent une impression d’irrationalité intense (Geuzaine & Faulx, 2000). Depuis notre position d’observateur extérieur, nous sommes face à un ensemble d’éléments qui heurtent la logique. Du point de vue de celui qui s’en sent victime, d’abord : une personne vit une situation d’abus sur son lieu de travail, elle nous décrit, dans un flot de détails, les agissements qu’elle subit et nous percevons l’intensité de son angoisse. Les affects sont à l’avant-plan, intenses et souvent désespérés. La personne se sent persécutée, bafouée, démolie, et pourtant tente obstinément de continuer à fonctionner dans une situation insupportable. Pourquoi ? Du point de vue de l’organisation, ensuite : le harcèlement moral, entre autres conséquences dommageables, entrave la productivité, augmente l’absentéisme, génère des surcoûts importants et détériore la qualité des produits et des services. Si un fonctionnement optimal et une bonne gestion des ressources humaines semblent un objectif profitable à l’organisation, comment le harcèlement moral peut-il s’y développer ? Lorsque l’on tente d’intégrer le « harceleur» au système compréhensif, l’irrationnel est de nouveau à l’avant-plan. En effet, les raisons qui amènent cette personne à développer un mode relationnel persécutoire ont beau être logiquement justifiées (« je veille à la qualité du travail et promeus l’excellence ». «cette personne ne répond pas aux critères », « c’est de mon devoir de la sanctionner ,«c’est pour qu’elle apprenne »), il n’en sert pas moins, même involontairement, des fins totalement irrationnelles : mettre en échec puis détruire psychologiquement une personne et l’évacuer du système professionnel en invoquant sa propre responsabilité, son déséquilibre, son inadaptation au travail. Pourquoi ? Le but de cet article est de présenter un modèle d’analyse qui permette de dépasser l’impression d’irrationalité qui se dégage des situations de harcèlement moral. Nous verrons qu’il existe une logique sous-jacente au processus de harcèlement moral; logique certes subjective et biaisée, mais à la base d’un système de comportements et d’attentes très influent. Après avoir exposé quelques repères théoriques, nous présenterons notre recherche et nos postulats méthodologiques. La partie consacrée à nos résultats s’articulera autour de deux axes : la présentation de certaines régularités parmi les situations de harcèlement moral et une réflexion sur l’aide que l’on peut proposer aux personnes qui en sont victimes. [less ▲]

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See detailSuivi de la végétation en zone sèche par des produits d‘information dérivés de l‘imagerie spatiale
Crépeau, Christian; Bennouna, Taoufiq; Bicheron, Patrice et al

in Science et changements planétaires / Sécheresse (2003), 14(1), 56-57

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See detailUse of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury
Wirth, D.; Christians, E.; Li, Xiang ULg et al

in Toxicology and Applied Pharmacology (2003), 192(1), 12-20

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection ... [more ▼]

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological changes occurring after Cd intranasal instillation (1 to 100 microg/mouse) was examined. HSF1-deficient mice were used to evaluate the role of this factor in lung protection. Cd instillation caused dose- and time-dependent changes in the respiratory pattern measured by plethysmography (Penh), and significant increases in lactate dehydrogenase (LDH) activity as well as macrophage and neutrophil counts in bronchoalveolar lavage fluids. HS preconditioning induced Hsp overexpression and reduced the Penh (-30%), LDH (-25%), and neutrophil (-55%) responses to subsequent administration of the highest Cd doses (50 and 100 microg) in wild-type mice. HSF1 deficiency abolished the HS response and its protective effect. In the absence of preconditioning, Hsf1(-/-) mice exhibited higher values of Penh (+70%) and LDH activity (+42%) compared with wild-type animals when exposed to the lowest Cd doses. Higher macrophage (+80%) and neutrophil counts (+115%) were recorded whatever the dose. Western blot analyses indicated that lung protection might be related to the kinetics of HSF1-dependent Hsp70 expression. Altogether, our data demonstrate that HS response elicited both by prior HS and by Cd itself moderates pulmonary injuries due to Cd instillation, and that HSF1 is a major mediator in this protection. [less ▲]

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See detailTopical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo.
Humbert, Philippe G; Haftek, Marek; Creidi, Pierre et al

in Experimental Dermatology (2003), 12(3), 237-44

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this ... [more ▼]

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this molecule as a potential candidate for use in the prevention and treatment of skin ageing. A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment. A double-blind, randomized trial was performed over a 6-month period, comparing the action of the vitamin C cream vs. excipient on photoaged skin. Clinical assessments included evaluation at the beginning and after 3 and 6 months of daily treatment. They were performed by the investigator and compared with the volunteer self assessment. Skin relief parameters were determined on silicone rubber replicas performed at the same time-points. Cutaneous biopsies were obtained at the end of the trial and investigated using immunohistochemistry and electron microscopy. Clinical examination by a dermatologist as well as self-assessment by the volunteers disclosed a significant improvement, in terms of the 'global score', on the vitamin C-treated side compared with the control. A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and well-tolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing. [less ▲]

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See detailInsectes et communication
Arnaud, Ludovic; Detrain, Claire; Gaspar, Charles et al

in Journal des Ingénieurs (Le) (2003), 87

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See detailThe core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin encoded by bovine herpesvirus 4 was acquired from an ancestor of the African buffalo
Markine-Goriaynoff, N.; Georgin, J. P.; Goltz, M. et al

in Journal of Virology (2003), 77(3), 1784-1792

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only viral gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M). To ... [more ▼]

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only viral gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M). To investigate the origin and evolution of the Bo17 gene, we analyzed its distribution among BoHV-4 strains and determined the sequences of Bo17 from nine representative strains and of the C2GnT-M gene from six species of ruminants expected to encompass the group within which the gene acquisition occurred. Of 34 strains of BoHV-4, isolated from four different continents, all were found to contain the Bo17 gene. Phylogenetic analyses indicated that Bo17 was acquired from a recent ancestor of the African buffalo, implying that cattle subsequently acquired BoHV-4 by cross-species transmission. The rate of synonymous nucleotide substitution in Bo17 was estimated at 5 x 10(-8) to 6 x 10(-8) substitutions/site/year, consistent with previous estimates made under the assumption that herpesviruses have cospeciated with their hosts. The Bo17 gene acquisition was dated to around 1.5 million years ago. Bo17 sequences from BoHV-4 strains from African buffalo and from cattle formed two separate clades, estimated to have split about 700,000 years ago. Analysis of the ratio of nonsynonymous to synonymous nucleotide substitutions revealed a burst of amino acid replacements subsequent to the transfer of the cellular gene to the viral genome, followed by a return to a strong constraint on nonsynonymous changes during the divergence of contemporary BoHV-4 strains. The Bo17 gene represents the most recent of the known herpesvirus gene acquisitions and provides the best opportunity for learning more about this important process of viral evolution. [less ▲]

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See detailDuane anomaly, congenital myopathy and severe scoliosis in sibs: new AR syndrome?
Verloes, Alain; Misson, Jean-Paul ULg; Gillet, Philippe ULg et al

in Annales de Génétique (2003), 46(4), 449-52

We report on two sisters who show a similar pattern of anomalies consisting of bilateral Stilling-Turk-Duane retraction syndrome (type 3), non-progressive hypotonia with delayed motor milestones but ... [more ▼]

We report on two sisters who show a similar pattern of anomalies consisting of bilateral Stilling-Turk-Duane retraction syndrome (type 3), non-progressive hypotonia with delayed motor milestones but normal intelligence, severe, early onset scoliosis, and short stature. Muscular biopsy revealed numerous regenerating fibers, but no specific abnormalities among the non-regenerating fibers. This combination of anomalies has not been previously reported, and could represent a new autosomal recessive syndrome. The only differential diagnosis is Crisfield-Dretakis-Sharpe syndrome, a combination of lateral gaze palsy, ptosis, and scoliosis without hypotonia, recessively inherited. [less ▲]

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See detailDouble radial immunodiffusion as a tool to identify pregnancy-associated glycoproteins in ruminant and nonruminant placentae
El Amiri, B.; Melo de Sousa, Noelita ULg; Mecif, K. et al

in Theriogenology (2003), 59(5-6), 1291-1301

Pregnancy-associated glycoproteins (PAGs) are antigens synthesized in the superficial layers of the ruminant trophoblast. Initially, they were identified either as proteins released into the maternal ... [more ▼]

Pregnancy-associated glycoproteins (PAGs) are antigens synthesized in the superficial layers of the ruminant trophoblast. Initially, they were identified either as proteins released into the maternal bloodstream (where they have applications in pregnancy diagnosis) (PAG1) or as molecules binding to the LH receptor (PAG2). In this study, double radial immunodiffusion was used to test the ability of antisera raised against different PAG molecules (bovine, ovine and caprine) to react with placental extracts from nonruminants (rabbit, cat, mouse, pig, and wild pig) and ruminants (cow, ewe, and goat). Placental extracts from all nonruminants tested except rabbit reacted with anti bovine PAG2 (anti-boPAG2). Extracts of ruminant placentas reacted with different antisera, confirming the expression of various PAG molecules. According to the time at which the placentas were collected (early or middle pregnancy), the reaction differed as regards the thickness, position, and number of precipitation lines, suggesting that PAG expression varies as pregnancy progresses. Bos indicus and Bos taurus placental extracts exhibited different reactions with anti-boPAG2: a single precipitation line in the former case and two lines in the latter. This suggests differential expression of boPAG2 related glycoproteins in these two subspecies. [less ▲]

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See detailEnseigner autrement : une expérience à l’Université de Liège
Merenne-Schoumaker, Bernadette ULg

in Géographes Associés (2003), (27), 183-184

Analyse d'une expérience en pédagogie active développée dans le cadre du cours de géographie urbaine à l'Université de Liège

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See detailBiodiversity, molecular phylogeny, and trophodynamics of amphipod crustaceans in the Antarctic deep-sea
De Broyer, Claude; Dauby, Patrick ULg; Nyssen, Fabienne et al

in Berichte zur Polar- und Meeresforschung (2003), 470

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See detailProcédure de liquidation-partage
Leleu, Yves-Henri ULg

in Revue de Droit de l'ULB (2003)

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See detailToward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides
De Tullio, Pascal ULg; Becker, B.; Boverie, S. et al

in Journal of Medicinal Chemistry (2003), 46

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See detailModeling lactation curves and estimation of genetic parameters for first lactation test-day records of French Holstein cows.
Druet, Tom ULg; Jaffrezic, F.; Boichard, D. et al

in Journal of Dairy Science (2003), 86(7), 2480-90

Several functions were used to model the fixed part of the lactation curve and genetic parameters of milk test-day records to estimate using French Holstein data. Parametric curves (Legendre polynomials ... [more ▼]

Several functions were used to model the fixed part of the lactation curve and genetic parameters of milk test-day records to estimate using French Holstein data. Parametric curves (Legendre polynomials, Ali-Schaeffer curve, Wilmink curve), fixed classes curves (5-d classes), and regression splines were tested. The latter were appealing because they adjusted the data well, were relatively insensitive to outliers, were flexible, and resulted in smooth curves without requiring the estimation of a large number of parameters. Genetic parameters were estimated with an Average Information REML algorithm where the average information matrix and the first derivatives of the likelihood functions were pooled over 10 samples. This approach made it possible to handle larger data sets. The residual variance was modeled as a quadratic function of days in milk. Quartic Legendre polynomials were used to estimate (co)variances of random effects. The estimates were within the range of most other studies. The greatest genetic variance was in the middle of the lactation while residual and permanent environmental variances mostly decreased during the lactation. The resulting heritability ranged from 0.15 to 0.40. The genetic correlation between the extreme parts of the lactation was 0.35 but genetic correlations were higher than 0.90 for a large part of the lactation. The use of the pooling approach resulted in smaller standard errors for the genetic parameters when compared to those obtained with a single sample. [less ▲]

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See detailTierce décision obligatoire et violation d'une règle de procédure conventionnellement arrêtée par les parties
Caprasse, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailResponse of coccolithophorid Emiliania huxleyi to elevated partial pressure of CO2 under nitrogen limitation
Sciandra, A.; Harlay, Jérôme ULg; Lefevre, D. et al

in Marine Ecology. Progress Series (2003), 261

Precipitation of calcium carbonate by phytoplankton in the photic oceanic layer is an important process regulating the carbon cycling and the exchange Of CO2 at the ocean-atmosphere interface. Previous ... [more ▼]

Precipitation of calcium carbonate by phytoplankton in the photic oceanic layer is an important process regulating the carbon cycling and the exchange Of CO2 at the ocean-atmosphere interface. Previous experiments have demonstrated that, under nutrient-sufficient conditions, doubling the partial pressure Of CO2 (pCO(2)) in seawater-a likely scenario for the end of the century-can significantly decrease both the rate of calcification by coccolithophorids and the ratio of inorganic to organic carbon production. The present work investigates the effects of high pCO(2) on calcification by the coccolithophore Emiliania huxleyi (Strain TW1) grown under nitrogen-limiting conditions, a situation that can also prevail in the ocean. Nitrogen limitation was achieved in NO3-limited continuous cultures renewed at the rate of 0.5 d(-1) and exposed to a saturating light level. pCO(2) was increased from 400 to 700 ppm and controlled by bubbling CO2-rich or CO2-free air into the cultures. The pCO(2) shift has a rapid effect on cell physiology that occurs within 2 cell divisions subsequent to the perturbation. Net calcification rate (C) decreased by 25% and, in contrast to previous studies with N-replete cultures, gross community production (GCP) and dark community respiration (DCR) also decreased. These results suggest that increasing pCO(2) has no noticeable effect on the calcification/photosynthesis ratio (C/P) when cells of E. huxleyi are NO3-limited. [less ▲]

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See detailLeclercq Suzanne.
Streel, Maurice ULg; Fairon-Demaret, M

in Académie Royale des sciences lettres et beaux arts de Belgique/ Nouvelle biographie nationale (2003), 7

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See detailModelling eutrophication in mesotidal and macrotidal estuaries. The role of intertidal seaweeds.
Alvera Azcarate, Aïda ULg; Ferreira, Joao; Nunes, Joao

in Estuarine Coastal & Shelf Science (2003), 57

The role of intertidal seaweeds in the primary production of mesotidal and macrotidal estuaries has been examined by means of a model, applied to the Tagus Estuary (Portugal). Special attention was paid ... [more ▼]

The role of intertidal seaweeds in the primary production of mesotidal and macrotidal estuaries has been examined by means of a model, applied to the Tagus Estuary (Portugal). Special attention was paid to the description of the underwater light climate in intertidal areas, and to the importance of the formation of tidal pools. Two approaches were compared for the simulation of suspended particulate matter (SPM) in the pool areas, using three algal species. The use of an erosion–deposition approach to simulate the distribution of SPM in tidal pools gives an increase in net primary productivity per unit area of between 130 and 1300%, when compared to the more conventional approach where the suspended matter in the overlying water in intertidal areas is considered identical to that in the channels. The upscaled erosion–deposition model was applied to tidal pool areas and combined with the more conventional model for other intertidal areas. Results show that annual carbon fixation by intertidal seaweeds in the estuary exceeds 13,500 t C yr−1, and accounts for 21% of the total carbon fixed by all primary producers. The corresponding nitrogen removal by seaweeds corresponds to the annual nutrient loading of a population of 490,000 inhabitants. [less ▲]

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See detailUpdate on GPIIb/IIIa antagonists
Hanson, Julien ULg; De Leval, X.; Kolh, Philippe ULg et al

in Expert Opinion on Therapeutic Patents (2003), 13

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See detailIn memoriam Roger Vigneron
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (2003), L

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See detailRetreatment of hepatitis C non-responsive to interferon. A placebo controlled randomized trial of ribavirin monotherapy versus combination therapy with Ribavirin and Interferon in 121 patients in the Benelux [ISRCTN53821378]
Veldt, Bart J; Brouwer, Johannes T; Adler, Michael et al

in BMC Gastroenterology (2003), 3(1), 24

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large ... [more ▼]

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large randomised controlled trial where combination therapy was compared to placebo therapy and to ribavirin monotherapy, which has not been published until now. METHODS: One hundred and twenty one patients with chronic hepatitis C and elevated transaminases who did not respond to previous treatment with standard interferon monotherapy, were included from 16 centers in Belgium, the Netherlands and Luxembourg between 1992 and 1996. Patient poor-response characteristics were: genotype 1 (69%), HCV RNA above 2 x 10(6) copies/ml (55%) and cirrhosis (38%). Patients were randomized to 6 months combination therapy with interferon alpha-2b (3 MU tiw) and ribavirin (1000-1200 mg/day), 6 months ribavirin monotherapy (1000-1200 mg/day) or 6 months ribavirin placebo. The study was double blinded for the ribavirin/placebo component. One patient did not fit the entry criteria, and 3 did not start. All 117 patients who received at least one dose of treatment were included in the intention to treat analysis. RESULTS: At the end of treatment, HCV RNA was undetectable in 35% of patients on combination therapy and in none of the patients treated with ribavirin monotherapy or placebo. The sustained virological response rate at 6 months after therapy was 15% for patients treated with interferon and ribavirin.During the 6 months treatment period 13% of patients on interferon ribavirin combination therapy, 13% of patients on ribavirin monotherapy and 11% of patients on placebo withdrew due to side effects or noncompliance. At 24 weeks of treatment the mean Hb level was 85% of the baseline value, which means a mean decrease from 9.1 mmol/l to 7.8 mmol/l. The Hb levels at the end of treatment were not significantly different from patients treated with ribavirin monotherapy (p = 0.76). End of treatment WBC was significantly lower in patients treated with combination therapy, compared to ribavirin (p < 0.01) as well as for patients treated with ribavirin monotherapy compared to placebo (p < 0.01). DISCUSSION: This belated report on the only placebo controlled study of interferon ribavirin combination therapy in non responders to standard doses of interferon monotherapy documents the effectiveness, be it limited, of this approach as well as the dynamics of the effects on blood counts. [less ▲]

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See detailThe contribution of recollection and familiarity to recognition memory : A study of the effects of test format and aging
Bastin, Christine ULg; Van der Linden, Martial ULg

in Neuropsychology (2003), 17(1), 14-24

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the ... [more ▼]

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the performance of 64 young (mean age = 21.7 years; mean education = 14.5 years) and 62 older participants (mean age = 64.4 years; mean education = 14.2 years) on a yes–no and a forced-choice recognition task for unfamiliar faces using the remember– know–guess procedure. Familiarity contributed more to forced-choice than to yes–no performance. Moreover, older participants, who showed a decrease in recollection together with an increase in familiarity, performed better on the forced-choice task than on the yes–no task, whereas younger participants showed the opposite pattern. [less ▲]

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See detailChronique de la 57ème Session de la SIHDA à Clermont-Ferrand (16-20 Septembre 2003)
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (2003), L

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See detailLa climatologie
Erpicum, Michel ULg; Alexandre, Jean ULg

in Bulletin de la Société Géographique de Liège (2003), 43(2003), 79-88

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See detailA arbitragem e os grupos de sociedades
Caprasse, Olivier ULg

in Revista de Direito Bancario, do Mercado de Capitais e da Arbitragem (2003)

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See detailRemarques sur l'élaboration de la conscience linguistique des Grecs
Rochette, Bruno ULg

in Glotta : Zeitschrift für Griechische und Lateinische Sprache (2003), 79

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See detailCommentaires sur la correction d'un travail écrit
Dumortier, Jean-Louis ULg

in Puzzle (2003), 14

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See detailProsthetic vascular infection complicated or not by aortoenteric fistula: comparison of treatment with and without cryopreserved allograft (homograft).
Lavigne, Jean-Paul ULg; Postal, Alain ULg; Kolh, Philippe ULg et al

in European Journal of Vascular and Endovascular Surgery (2003), 25(5), 416-23

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study ... [more ▼]

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study. MATERIAL AND METHODS: two asynchronous series of 44 [series I: 1980-1994; 8 patients with aortoenteric fistula (AEF)] and 22 (series II: 1994-1997; 4 patients with AEF) patients were treated for prosthesis infection. All patients had prosthesis excision. In series I, there were 4 in situ reparations, 26 extra-anatomic bypass, 13 excision only, and one death at laparotomy. In series II, in situ cryopreserved allografts were implanted in all patients. RESULTS: operative mortality was 16% in series I and 13.6% in series II. For AEF patients, mortality was 37% in series I and 50% in series II. Among hospital survivors, infection-related late mortality was 13.5% in series I and 5% in series II. For AEF patients, late mortality was 20% in series I and 50% in series II. Incidence of reoperations was 54% in series I and 10.5% in series II (p<0.01). Hospital stay was 47.2+/-26.4 days in series I and 16.6+/-11.5 days in series II (p<0.001). CONCLUSIONS: compared to conventional treatment, incidence of reoperations and length of hospital stay are significantly decreased after cryopreserved allograft implantation. However, closure of aortic stump and extra-anatomic bypass gives better results for patients with AEF. [less ▲]

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See detailEffect of residence time on the efficacy of antidandruff shampoos.
Pierard, Claudine ULg; Uhoda, Emmanuelle ULg; Loussouarn, G. et al

in International Journal of Cosmetic Science (2003), 25(6), 267-71

Dandruff is known to be controlled by fungistatic shampoos active against Malassezia spp. These products also remove the loosely attached scales. This study was performed to assess the effect of a 5-min ... [more ▼]

Dandruff is known to be controlled by fungistatic shampoos active against Malassezia spp. These products also remove the loosely attached scales. This study was performed to assess the effect of a 5-min residence time on the efficacy of antidandruff shampoos. Two commercially available shampoos were used in two groups of 21 panelists with severe dandruff. They contained either 1% ketoconazole or 1% piroctone olamine. In each group, intraindividual comparisons were made by a split-scalp design between the effect of a 5-min residence time versus no residence time. Both shampoos induced significant reductions in scaliness and yeast colonization. The beneficial effects were obvious immediately after one single shampooing and 3 days later as well. The improvement was greater with a 5-min residence time. The piroctone olamine treatment benefited more than the ketoconazole treatment from the extension of shampoo-exposure time. In conclusion, the benefit of a residence time in treating dandruff is documented. The level of improvement in efficacy may vary according to the nature of the shampoo. [less ▲]

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See detailnote sous arrêt du 23 octobre 2003, Van den Bergh Foods contre Commission
Petit, Nicolas ULg

in Revue du Droit de l'Union Européenne (2003)

résumé et analyse de l'affaire Volkswagen AG contre Commission, affaire C-338/00

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See detailImplications cliniques de l'association d'un tonus sympathique accru, du syndrome métabolique et de l'hypertension
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2003), 2

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See detailCutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision.
Claessens, Nadine; Heymans, Olivier; Arrese Estrada, Jorge ULg et al

in American Journal of Clinical Dermatology (2003), 4(11), 799-802

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which ... [more ▼]

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which consists of various, but specific, tumors. OBJECTIVE: We report two cases of subcutaneous melanotic schwannoma localized on the trunk in two men aged 37 and 45 years. METHODS: Conventional histology and immunohistochemistry were performed. RESULTS: One melanotic schwannoma was associated with a cutaneous atypical myxoma and multiple melanocytic lesions, all being part of the Carney complex. The other case had no associated signs. In both cases, the melanotic schwannoma was completely excised and did not recur. CONCLUSION: Melanotic schwannoma is rare and curable by surgery. It must not be confused with malignant melanoma and other pigmented neoplasms. The Carney complex should be carefully ruled out. [less ▲]

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See detailZoektocht naar een levende prothese
De Gersem, Hilde; Geris, Liesbet ULg

in Het Ingenieursblad (2003), 72(8/9), 54-60

De huidige behandelingstechnieken voor grote botdefecten zoals zware trauma’s en tumoren zijn vaak onbevredigend. Zo is het langetermijneffect niet altijd gewaarborgd, bv. bij het loskomen van prothesen ... [more ▼]

De huidige behandelingstechnieken voor grote botdefecten zoals zware trauma’s en tumoren zijn vaak onbevredigend. Zo is het langetermijneffect niet altijd gewaarborgd, bv. bij het loskomen van prothesen, of zorgt de behandeling niet voor volledig herstel van de functionaliteit. Vooral bij grote botdefecten is de vraag naar een permanente, biologische en patiëntvriendelijkere oplossing groot. Dit artikel kadert in het onderzoek naar een behandeling met behulp van met botcellen ingezaaide poreuze draagstructuren. [less ▲]

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See detailThermometer ions for matrix-enhanced laser desorption/ionization internal energy calibration
Greisch, Jean-François ULg; Gabelica, Valérie ULg; Remacle, Françoise ULg et al

in Rapid Communications in Mass Spectrometry : RCM (2003), 17(16), 1847-1854

This work describes a method to use relative fragmentation yields to characterize the internal energy distribution of ions produced by matrix-enhanced laser desorption/ionization mass spectrometry (MELDI ... [more ▼]

This work describes a method to use relative fragmentation yields to characterize the internal energy distribution of ions produced by matrix-enhanced laser desorption/ionization mass spectrometry (MELDI-MS, see: Wright LG, Cooks RG, Wood KL. Biomed. Mass Spectrom. 1985; 12:153162). Assuming that the fragmentation proceeds statistically and that the collisions in the source lead to a Boltzmann-like distribution of the internal energy, a characteristic parameter, the effective temperature, is introduced to describe the internal energy distribution of the ions observed. The hypotheses, advantages and drawbacks of the implementation of the method that uses substituted benzylpyridinium salts as thermometer ions are discussed. Use is made of two matrices that produce no matrix cations in MELDI and are suitable for small cationic salts. The actual value of this effective temperature significantly depends on an accurate determination of the threshold dissociation energies and on the time spent in the source, in addition to the statistical hypothesis itself. The method could be applied to normalize spectra in order to compare results issued from different instruments. [less ▲]

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See detailTraitement de l'hypertension dans le syndrome métabolique et la néphropathie
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2003), 2

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See detailImmunocytochemical detection of DNA and RNA in endosymbiont-bearing trypanosomatids.
Motta, Maria Cristina M; de Souza, Wanderley; Thiry, Marc ULg

in FEMS Microbiology Letters (2003), 221(1), 17-23

Research about the kinetoplast of trypanosomatids has yielded valuable information about the organization of extranuclear structure. However, the ultrastructural localization of nucleic acids within these ... [more ▼]

Research about the kinetoplast of trypanosomatids has yielded valuable information about the organization of extranuclear structure. However, the ultrastructural localization of nucleic acids within these protozoa remains uncertain. We have applied cytochemical and immunocytochemical approaches to precisely identify DNA and RNA in lower endosymbiont-bearing trypanosomatids. Using the Terminal deoxynucleotidyl Transferase (TdT) immunogold technique, we showed that nuclear DNA is seen associated with the nuclear envelope during the trypanosomatid cell cycle. By combining the TdT technique with the acetylation method, which improves the contrast between structures containing fibrils and granules, we have demonstrated that the nucleolus of endosymbiont-bearing trypanosomatids is composed of two constituents: a granular component and a DNA-positive fibrillar zone. Moreover, we revealed that DNA of endosymbiotic bacteria consisted of electron-dense filaments which are usually in close contact with the prokaryote envelope. Using a Lowicryl post-embedding immunogold labeling procedure with anti-RNA antibodies, we showed the presence of RNA not only over the cytoplasm, the interchromatin spaces and the nucleolus, but also over the kinetoplast and virus-like particles present in Crithidia desouzai. [less ▲]

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See detailRhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.
Clercx, Cécile ULg; Reichler, I.; Peeters, Dominique ULg et al

in Journal of Veterinary Internal Medicine (2003), 17(6), 843-9

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK ... [more ▼]

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent rhinorrhea, cough, and respiratory dyspnea. Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected dogs, but no characteristic primary ciliary defects (primary ciliary dyskinesia) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected dogs and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected dogs tested, whereas BALF IgA concentration was above the normal range in 2 affected adult dogs. The CD4 to CD8 lymphocyte subset ratio (CD4:CD8) in peripheral blood was tested in 3 affected dogs and was within the normal range. BALF CD4:CD8 was tested in 1 affected dog and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 dogs tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss dogs revealed common ancestry, suggesting a heritable syndrome. [less ▲]

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See detailXylanase Production By Penicillium Canescens 10-10c In Solid-State Fermentation
Bakri, Y.; Jacques, Philippe ULg; Thonart, Philippe ULg

in Applied Biochemistry and Biotechnology (2003), 105

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See detailEffect of rival males on the courtship of paedomorphic and metamorphic Triturus alpestris (Amphibia : Salamandridae)
Denoël, Mathieu ULg

in Copeia (2003), 2003(3), 618-623

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and ... [more ▼]

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and salamanders is a suitable process to explore this question because it implies the coexistence of two different morphological morphs differing by the presence of gills and epigamic traits. The aim of this study was to find out whether paedomorphs and metamorphs use similar tactics to attract mates in the presence of a rival and whether there are differences in sexual activity and success between alternative morphs. Sexual interactions in triadic encounters were staged and analyzed in a standardized experimental design. The two kinds of males did not differ in terms of sexual activity, spermatophore deposition or female responsiveness. Both rival paedomorphic and metamorphic males exhibited sexual interference, but in most encounters, intruders just disturbed the courting pair. Sperm transfer success was lower in triadic encounters than in dyadic encounters. These results illustrate that intermorph breeding also occurs in the presence of competitors but that the success rate of the newts is considerably decreased in such competitive situations. Moreover, newts do not use alternative reproductive tactics depending on their status (i.e., paedomorph or metamorph). [less ▲]

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See detailCalculation of bovine haemoglobin oxygen saturation by algorithms integrating age, haemoglobin content, blood pH, partial pressures of oxygen and carbon dioxide in the blood, and temperature.
Detry, Benoit; Cambier, Carole ULg; Frans, A. et al

in Veterinary Journal (2003), 165(3), 258-265

In human and veterinary medicine, arterial and venous haemoglobin oxygen saturations are often used to estimate the severity of a disease and to guide therapeutic decisions. In veterinary medicine ... [more ▼]

In human and veterinary medicine, arterial and venous haemoglobin oxygen saturations are often used to estimate the severity of a disease and to guide therapeutic decisions. In veterinary medicine, haemoglobin oxygen saturation (SO(2)) is usually calculated using a blood gas analyser and algorithms developed for humans. It is possible, therefore, that the values obtained in animals may be distorted, particularly in animals with a high haemoglobin oxygen affinity, like young calves. In order to verify this hypothesis, we compared the arterial (SaO(2)) and venous (SvO(2)) haemoglobin oxygen saturations calculated using three different algorithms, and the oxygen exchange fraction (OEF) at the tissue level, which is the degree of haemoglobin desaturation between arterial and venous blood (SaO(2)-SvO(2)), with the values obtained from the whole bovine oxygen equilibrium curve (OEC) determined by a reference method. The blood gas analysers underestimated SvO(2) values; consequently, the OEF was overestimated (by about 10%). Two methods of reducing these errors were assessed. As the haemoglobin oxygen affinity decreases during the first month of life in calves a relationship between PO(2) at 50% haemoglobin saturation (P50) and age was established in order to correct the calculated values of venous and arterial SO(2), taking into account the estimated position of the OEC. This method markedly reduced the error for SvO(2) and OEF. Secondly, the SO(2) was calculated using a mathematical model taking into account the age of the animal and the specific effects of pH, PCO(2), and temperature on the bovine OEC. Using this method, the mean difference between the OEF values calculated using the mathematical model and those calculated by the reference method was close to zero. The errors produced by blood gas analysers can thus be minimised in two ways: firstly, by simply introducing a P50 estimated from the age of the calf into the analyser before the measurement; and secondly, by calculating the SO(2) using a mathematical model applied to the bovine OEC. [less ▲]

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See detailUn acte de mécénat d'Aubert Le Mire (1573-1640) en faveur des Dominicains de Bruxelles
Adam, Renaud ULg

in Revue du Cercle d'Histoire de Bruxelles et Extensions (2003), 79

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See detailEfficacité du piégeage, par les méthodes classiques, des coléoptères saproxyliques en Région wallonne (Belgique)
Lhoir, Jonathan; Fagot, Jean ULg; Thieren, Yves et al

in Notes Fauniques de Gembloux (2003), 50

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont ... [more ▼]

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont (Daverdisse village). Both forests are caracterized by a large amount of dead wood standing and laying down. The trapping's results are presented, with regards on the different technics used, on the differences between sites, on the beetles families and their saproxylic behavior. [less ▲]

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See detailMediolatinitas : légendes hagiographiques et statistique linguistique
Philippart de Foy, Caroline ULg

in Hagiographica : Rivista di Agiografia e Biografia della Società Internazionale per lo Studio del Medioevo Latino (2003), X

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See detailSkin-lightening products revisited.
Petit, Ludivine; Pierard, Gérald ULg

in International Journal of Cosmetic Science (2003), 25(4), 169-81

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and ... [more ▼]

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and phaeomelanins are of utmost importance. These biomolecules result from the multi-step enzymatic and non-enzymatic conversion of tyrosine into melanins. Pigmentation disorders are multiple and depend on alterations in the density in active melanocytes, and on specific abnormalities of any of the complex melanogenesis mechanisms. This review presents some of the main skin-lightening agents with respect to their mechanisms of action and side-effects. Some of the novel compounds may lead to new perspectives in the fields of dermatology and cosmetology. The methods commonly used to assess efficacy of skin-lightening products rely on in vitro models including cell-free enzymatic assays, melanocyte cultures and reconstructed epidermis bioassays. Animal models have little relevance. By contrast, human testing with the support of instrumental evaluations is the most informative. [less ▲]

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See detailHematopoietic cell transplantation: five decades of progress.
Baron, Frédéric ULg; Storb, Rainer; Little, Marie-Terese

in Archives of Medical Research (2003), 34(6), 528-44

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative ... [more ▼]

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative treatment modality for thousands of patients with hematologic diseases. Now, cure rates following human leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or thalassemia. In addition, the recent development of non-myeloablative conditioning and stem cell transplantation has opened the way to include elderly patients with a wide variety of hematologic malignancies. Further progress in adoptive transfer of T cell populations with relative tumor specificity would make the transplant procedure more effective and would extend the use of allogeneic HCT for treatment of non-hematopoietic malignancies. [less ▲]

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See detailCompte-rendu de l'ouvrage de I. Loudon (ed.) : Western Medicine. An Illustrated History
Nissen, Cécile ULg

in Archives Internationales d'Histoire des Sciences (2003)

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See detailA review of the major causes of digestive disorders in the European rabbit
Marlier, Didier ULg; Dewrée, Roxane; Delleur, Valéry et al

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 385-392

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state ... [more ▼]

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state of knowledge on two diseases of unknown origin, the so called Rabbit Epizootic Enteropathy and Mucoid Enteropathy is also presented. [less ▲]

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See detailLes teignes du cuir chevelu d'ici et d'ailleurs. Quand la prévention est à géographie variable.
Arrese Estrada, Jorge ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(6), 388-91

Few diseases exhibit such regional variability in their epidemiology, even in an area as limited as Belgium, as tinea capitis. Thus, anthropophilic tinea capitis is highly predominant in areas where new ... [more ▼]

Few diseases exhibit such regional variability in their epidemiology, even in an area as limited as Belgium, as tinea capitis. Thus, anthropophilic tinea capitis is highly predominant in areas where new immigrants from Black Africa and North Africa have settled. By contrast, zoophilic tinea capitis is found largely in areas where the cat population is infected. Kerion often affects professions in which contact with infected livestock is involved. Prevention of tinea capitis thus has distinct regional features. Treatment, on the other hand, has a universal basis. [less ▲]

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See detailMoins-values et plus-values d'urbanisme: La révision de l'article 70 du CWATUP
Pâques, Michel ULg

in Revue du Notariat Belge (2003)

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See detailProstaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells.
Gosset, Philippe; Bureau, Fabrice ULg; Angeli, Veronique et al

in Journal of Immunology (2003), 170(10), 4943-52

Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2 ... [more ▼]

Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2) are in part effected through two plasma membrane G protein-coupled receptors: the D prostanoid (DP) receptor and the chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTH2). In this report, we studied the effects of PGD(2) and of its major physiological metabolite, 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), on the functions of human monocyte-derived DC. First, we show that PGD(2) exerts in vitro chemotactic effects on monocytes via CRTH2 activation while it inhibits the chemokine-driven migration of monocyte-derived DC through DP. We also report that PGD(2) and 15d-PGJ(2) alter the LPS- and allergen-induced DC maturation and enhance the CD80/CD86 ratio on mature DC in a DP- and CRTH2-independent manner. Moreover, PGD(2) and 15d-PGJ(2) strongly reduce the secretion of the Th1 promoting cytokine IL-12 and affect the synthesis of chemokines involved in Th1 cell chemotaxis, particularly CXCL10. Inhibition of cytokine/chemokine secretion implicates at least in part DP, but not CRTH2. The effects exerted by PGD(2) are associated with the phosphorylation of CREB, but do not parallel with the deactivation of the NF-kappa B and mitogen-activated protein kinase pathways. In contrast, 15d-PGJ(2) seems to target other cellular proteins. Finally, in a model of Th CD45RA(+) differentiation induced by allergen- and superantigen-pulsed DC, PGD(2) impacts on the orientation of the immune response by favoring a Th2 response [less ▲]

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See detailDuplex ultrasound as first-line screening test for patients suspected of renal artery stenosis: prospective evaluation in high-risk group.
NCHIMI LONGANG, Alain ULg; Biquet, J. F.; Brisbois, D. et al

in European Radiology (2003), 13(6), 1413-9

Our objective was to assess how far the progress in ultrasound devices has increased feasibility and accuracy of Duplex ultrasound (DUS) for the diagnosis of renal artery stenosis (RAS), in a population ... [more ▼]

Our objective was to assess how far the progress in ultrasound devices has increased feasibility and accuracy of Duplex ultrasound (DUS) for the diagnosis of renal artery stenosis (RAS), in a population with high prevalence of atherosclerotic renovascular lesions. Ninety-one hypertensive patients with atherosclerotic disease were prospectively evaluated by both DUS and digital subtraction angiography (DSA) of the renal arteries. Only proximal criteria (peak systolic velocity >180 mm/s or renal-to-aortic ratio >3.5) were used for the diagnosis of significant RAS (>60% narrowing). For both techniques, two readers were involved for interobserver variability study. Two hundred one arteries were demonstrated by DSA on 182 available kidneys. The prevalence of RAS among the study group was 37%. Sixteen of the 19 accessory arteries were not seen at DUS; in 8 patients, one renal artery was not seen at DUS (feasibility 91%). On the 177 arteries assessed, in comparison with DSA, DUS yielded 96, 91, and 97% mean values of accuracy, sensitivity, and specificity, respectively. Kappa for interobserver agreement was 0.95 for DUS and 0.92 for DSA. Although still unreliable for the detection of accessory arteries, DUS is in our experience an accurate and reproducible diagnostic test for RAS. [less ▲]

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULg et al

in Acta Crystallographica (2003)

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See detailAttitudes et controverses dans la prevention secondaire de l'accident ischemique cerebral.
HANS, Grégory ULg; Sadzot, Bernard ULg; Moonen, Gustave ULg

in Revue medicale de Liege (2003), 58(5), 287-92

Stroke is the third leading cause of death and the main cause of prolonged disability of adults in industrialised countries. After a first transient ischemic attack or a first minor stroke, the risk of ... [more ▼]

Stroke is the third leading cause of death and the main cause of prolonged disability of adults in industrialised countries. After a first transient ischemic attack or a first minor stroke, the risk of recurrence is 16 folds higher than in control subjects. Therefore each patient suspect of a first ischemic cerebral event should be evaluated for the presence of a specific cause which could be treated. If such a cause is not found, platelet antiaggregant medications should be started. [less ▲]

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See detailOndelettes et télédétection
Charles, Catherine ULg; Rasson, Jean-Paul

in Revue des Nouvelles Technologies de l'Information (2003), 1

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See detailFeasibility and reproducibility of off-line tissue Doppler measurement of regional myocardial function during dobutamine stress echocardiography.
Fraser, A. G.; Payne, N.; Madler, C. F. et al

in European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology (2003), 4(1), 43-53

AIMS: Off-line post-processing of colour tissue Doppler from digital loops may allow objective quantification of dobutamine stress echocardiography. We assessed the reproducibility of off-line ... [more ▼]

AIMS: Off-line post-processing of colour tissue Doppler from digital loops may allow objective quantification of dobutamine stress echocardiography. We assessed the reproducibility of off-line measurements of regional myocardial velocities. METHODS AND RESULTS: Nine observers analysed 10 studies, each making 2400 observations. Coefficients of variation in basal segments from apical windows, at rest and maximal stress, were 9-14% and 11-18% for peak systolic velocity, 16-18% and 17-19% for time-to-peak systolic velocity, 9-17% and 18-24% for systolic velocity time integral, and 18-23% and 21-27% for systolic acceleration. Coefficients of variation for diastolic velocities in basal segments at rest were 11-40%. Coefficients of variation for peak systolic velocity were 10-24% at rest and 14-28% at peak in mid segments, and 19-53% and 29-69% in apical segments. From parasternal windows coefficients of variation for peak systolic velocity were 14-16% in basal posterior, and 19-29% in mid-anterior segments. High variability makes measurement unreliable in apical and basal anterior septal segments. The feasibility of obtaining traces was tested in 92 subjects, and >90% in all basal and mid segments apart from the anterior septum. CONCLUSION: Quantification of myocardial functional reserve by off-line analysis of colour tissue Doppler acquired during dobutamine stress is feasible and reproducible in 11 segments of the left ventricle. The most reliable measurements are systolic velocities of longitudinal motion in basal segments. [less ▲]

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See detailTuning of ruthenium N-heterocyclic carbene catalysts for ATRP
Delaude, Lionel ULg; Delfosse, Sébastien ULg; Richel, Aurore ULg et al

in Chemical Communications (2003), (13), 1526-1527

Depending on the substituents, R-1 and R-2, ruthenium(II) - p-cymene complexes bearing N-heterocyclic carbene ligands are either efficient catalysts for the well-controlled atom transfer radical ... [more ▼]

Depending on the substituents, R-1 and R-2, ruthenium(II) - p-cymene complexes bearing N-heterocyclic carbene ligands are either efficient catalysts for the well-controlled atom transfer radical polymerisation of methyl methacrylate and styrene, or promote a redox-initiated free-radical process. [less ▲]

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See detailThe lichen genus Caprettia Bat. & H. Maia
Sérusiaux, Emmanuël ULg; Lücking, Robert

in Bibliotheca Lichenologica (2003), 86

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See detailSystemic osmotic manipulations modulate ethanol-induced taurine release : a brain microdialysis study
Quertemont, Etienne ULg; Devitgh, Audrey; De Witte, Philippe

in Alcohol (2003), 29(1), 11-19

In recent microdialysis studies, increased extracellular concentrations of taurine after high ethanol dose administration were identified in various rat brain regions. The mechanisms by which ethanol ... [more ▼]

In recent microdialysis studies, increased extracellular concentrations of taurine after high ethanol dose administration were identified in various rat brain regions. The mechanisms by which ethanol caused these increases in extracellular taurine concentration remained unclear but could be related to ethanol-induced cell swelling. The aim of the current study was to investigate whether changes in the body osmotic state modulate the effects of ethanol on brain extracellular taurine concentrations. In several groups of rats, brain hypoosmotic or hyperosmotic states were superimposed on acute ethanol (2.0-g/kg) injections, and extracellular taurine concentrations within the nucleus accumbens were assessed by using an intracerebral microdialysis procedure. A hypoosmotic state was obtained by systemic administration of water while hyperosmotic states were induced by intraperitoneal injections of hypertonic saline solutions (1.8% or 3.6% saline). In isoosmotic conditions, ethanol induced an immediate and significant increase in taurine microdialysate content, confirming results of previous studies. However, the effects of ethanol on taurine concentrations were modulated by osmotic manipulations. Hypoosmotic conditions significantly potentiated ethanol-induced taurine release. In contrast, ethanol-induced increases in extracellular taurine levels were attenuated by 1.8% saline injection and totally prevented by 3.6% saline administration. These results strongly argue in favor of a primary role, of osmoregulation in ethanol-induced taurine release. Ethanol-induced cell swelling probably activates volume-sensitive channels, and taurine passively diffuses outside the cells along its concentration gradient. (C) 2003 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailTwo-dimensional harmonic balance finite element modelling of electrical machines taking motion into account
Gyselinck, Johan; Dular, Patrick ULg; Vandevelde, Lieven et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2003), 22(4), 1021-1036

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system ... [more ▼]

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system of algebraic equations is derived by applying the Galerkin approach to both the space and time discretisation. The harmonic basis functions, i.e. a cosine and a sine function for each nonzero frequency and a constant function 1 for the DC component, are used for approximating the periodic time variation as well as for weighing the time domain equations in the fundamental period. In practice, this requires some elementary manipulations of the moving band stiffness matrix. Magnetic saturation and electrical circuit coupling are considered in the analysis as well. As an application example, the noload operation of a permanent-magnet machine is considered. The voltage and induction waveforms obtained with the proposed harmonic balance method are shown to converge well to those obtained with time stepping. [less ▲]

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See detailDevelopment of a new high-speed steel with optimized carbide composition for mill rolls
Lecomte-Beckers, Jacqueline ULg; Tchuindjang, Jérôme Tchoufack ULg; Pirard, Eric ULg et al

in Stal' (2003), 2

High Speed Steel (HSS) cast rolls are used in front finishing stands of hot strip mills. Good wear resistance and hardness at high temperatures, are defining features of HSS. Many types of carbides are ... [more ▼]

High Speed Steel (HSS) cast rolls are used in front finishing stands of hot strip mills. Good wear resistance and hardness at high temperatures, are defining features of HSS. Many types of carbides are present in these alloys, each having different effect upon their final properties. As a result, nature, morphology and amount of these carbides are factors of important concern. Identification and characterisation of carbides were realised. MC, M2C, M7C3 carbides were found. Some relationships with mechanical properties were obtained especially in the field of the solidification sequence that affects grain size and carbides dispersion. [less ▲]

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See detail'Aangewaaid uit een vreemd land': de westerse poëzie van G.J. Resink
Steyaert, Kris ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2003), 119(4), 279-299

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have ... [more ▼]

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have very much focused on what they perceive to be 'eastern' elements in Resink's oeuvre. I maintain that this has resulted in a one-sided interpretation, neglecting the underlying western, and in particular Dutch, tradition in many of Resink's poems. This article demonstrates the different ways in which Resink drew on the principles and literary output of the Eighties Movement, and how his formal experiments gain in significance when set against the work of poets like Perk, Kloos, and Dèr Mouw. The general view on Resink's later work as being inferior to his earlier poetry is shown to be the result of unwarranted preconceptions. [less ▲]

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See detailSensitivity analysis on ultimate strength of aluminium stiffened panels
Rigo, Philippe ULg; Sarghiuta, B.; Estefen, S. et al

in Marine Structures (2003)

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See detailLiodopria serricornis (Gyllenhal, 1813) (Coleoptera: Liodidae), nouvelle espèce pour la faune belge
Thieren, Yves; Fagot, Jean ULg; Lhoir, Jonathan

in Notes Fauniques de Gembloux (2003), 50

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