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See detailLa cardiomyoplastie
RADERMECKER, Marc ULg; Fourny, J.; Limet, Raymond ULg

in Revue Médicale de Liège (1992), 47(3), 140-4

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See detailCorrespondence analysis for quantification in electron energy loss spectroscopy and imaging.
Gelsema, E. S.; Beckers, Albert ULg; Sorber, C. W. et al

in Methods of Information in Medicine (1992), 31(1), 29-35

Electron energy loss spectroscopy (EELS) is a technique to investigate the physical properties of material. Using this technique it is possible to detect the presence of a specific element in a specimen ... [more ▼]

Electron energy loss spectroscopy (EELS) is a technique to investigate the physical properties of material. Using this technique it is possible to detect the presence of a specific element in a specimen. When used in combination with an electron microscope, energy filtered images may be obtained, which in principle may be used to quantify the local element concentration. This involves a process of background correction, conventionally performed assuming a specific parametric behavior of the spectral intensity as a function of electron energy loss. In this article a parameter-free method is described for background correction based on the formalism of correspondence analysis. Such a method may be used in parts of the spectrum where the functional dependence of the spectral intensity is unknown. Use of this method for element detection has been suggested before. This article reports simulation experiments suggesting its suitability for quantitative determination of element distributions and element concentrations. [less ▲]

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See detailUn voyageur impénitent
Tilkin, Françoise ULg

in Ecritures (1992), 2

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See detailPlasma myeloperoxidase and vitamin E levels in head injury: preliminary results related to outcome.
Hans, Pol ULg; Franssen, Colette ULg; Pincemail, Joël ULg et al

in Journal of Neurosurgical Anesthesiology (1992), 4(1), 26-30

This preliminary study was designed to assess a possible role of neutrophil activation and to determine the prognostic value of plasma myeloperoxidase (MPO) and vitamin E (Vit. E) levels in severe head ... [more ▼]

This preliminary study was designed to assess a possible role of neutrophil activation and to determine the prognostic value of plasma myeloperoxidase (MPO) and vitamin E (Vit. E) levels in severe head injury. Plasma MPO and Vit. E levels were measured in nine severely head-injured patients (Glasgow Coma Score </=8) (ages 12-80 years) 6, 12. 18, 24, and 30 h after trauma. Patients were classified into two groups according to outcome after discharge from the ICU: group D (death; n = 5) and group S (survival; n = 4). Plasma MPO levels were increased immediately after trauma and then decreased. The MPO peak observed after 6 h was significantly higher (p < 0.05) in group D (mean +/- SEM: 1,237 +/- 122 ng/ml) than in group S (mean +/- SEM: 543 +/- 148 ng/ml). Plasma Vit. E levels were lower than normal values and decreased over time. They were always significantly lower (p < 0.05) in group D than in group S, except for the first sample. These differences cannot be explained entirely by total plasma lipid (TL) values since no statistical difference in TL concentrations was found between the two groups during the course of study. The ratio of Vit. E to TL. considered as the best index of Vit. E status, was lower in group D than in group S. and the difference reached statistical significance (p < 0.05) 12 h after trauma. In conclusion, in spite of the limited number of patients included in this study, it appears that severe head injury is associated with an increase in MPO and a decrease in Vit. E levels. These biochemical changes are of greater magnitude in group D than in group S; they suggest neutrophil activation and lipoperoxidation processes. Finally, plasma MPO and Vit. E seem to be new discriminant factors of outcome in head-injured patients. [less ▲]

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See detailEtude préliminaire du comportement d'hybridation de Barbus barbus (L.) et de Barbus meridionalis (Risso) en aquarium.
Jeandarme, J.; Poncin, Pascal ULg; Berrebi, P.

in Cahiers d'Ethologie Appliquée (1992), 11(4), 519-528

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See detailNouvelles approches pharmacologiques basées sur les interactions neuroendocrino-immunitaires
Geenen, Vincent ULg; Franchimont, Nathalie; Louis, Edouard ULg et al

in Médecine et Hygiène (1992), 50

La description des interactions neuroendocrino-immunitaires a été un domaine de recherche très fructueux au cours des dernières années. Si les circonstances physiopathologiques au cours desquelles ces ... [more ▼]

La description des interactions neuroendocrino-immunitaires a été un domaine de recherche très fructueux au cours des dernières années. Si les circonstances physiopathologiques au cours desquelles ces interactions interviennent restent encore à préciser, la caractérisation biochimique de signaux neuropeptidiques et de leurs récepteus exprimés par des cellules immunocompétentes permet d'entrevoir de nouvelles possibilités thérapeutiques. En particulier, l'action immunomodulatrice et antiinflammatoire potentielle d'antagonistes spécifiques de neuropeptides représente une voie intéressante pour la mise au point d'immunothérapies sélectives. [less ▲]

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See detailExpression of functional neurohypophysial peptide receptors by murine immature and cytotoxic T-cell lines
Martens, Henri ULg; Robert, Françoise; Geenen, Vincent ULg et al

in Progress in NeuroEndocrinImmunology (1992), 5

In order to demonstrate the cryptocrine model of neuroendocrine-immune interactions, specific neurohypophysial (NHP) receptors were detected on murine immature pre-T and cytotoxic T cell lines. A computer ... [more ▼]

In order to demonstrate the cryptocrine model of neuroendocrine-immune interactions, specific neurohypophysial (NHP) receptors were detected on murine immature pre-T and cytotoxic T cell lines. A computer analysis (LIGAND) revealed the heterogeneity of the binding sites. The Kd of Highest affinity were equivalent in both cell lines (0.15 nM), but the capacity (Bmax) of both low and high affinity sites was higher in the immature thymic lymphoma-derived pre-T-cell line. The functionality of these receptors was evidenced by their transduction of NHP-related ligands as an increase in intracellular inositol phosphates. These transductory properties were inhibited by a V1 receptor antagonist in pre-T cells, and by an oxytocin (OT) receptor antagonist in cytotoxic T cells. This work supports the involvement of NHP-related ligands and receptors in a process of cryptocrine signaling in the thymus, where the peptide concentration and the receptor affinity are in appropriate concordance. [less ▲]

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See detailEnergy hypersurface local properties of the O2HF-1 rearrangement
Dive, Georges ULg; Dehareng, Dominique ULg; Culot, Patrick et al

in Chemical Physics Letters (1992), 195(2-3), 189-193

This work analyses a case where Murrell's proposal, stating that a second-order point must lie above a first-order one, is apparently violated. Study at the SCF-UMP2 level within the D95 + + basis set, of ... [more ▼]

This work analyses a case where Murrell's proposal, stating that a second-order point must lie above a first-order one, is apparently violated. Study at the SCF-UMP2 level within the D95 + + basis set, of one critical point of the O2HF- anion, previously proposed to be of order two by Lopez, shows the importance of the electronic correlation. The critical point associated with the (2)PI first-order ones. The present analysis reveals that this contradistinction can be explained by three unconsidered elements: the local symmetry, the electronic correlation and the internal variables description. [less ▲]

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See detailLa matière en suspension de la couche de surface du plateau continental nord-ouest européen. I. Distribution spatiale de la biomasse et du rapport 13C/12C
Dauby, Patrick ULg; Mosora, Fiorentina; Frankignoulle, Michel et al

in Bulletin de la Société Royale des Sciences de Liège (1992), 61

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See detailPh. Vendrix (éd.), « Grétry et l’Europe de l’opéra comique »
Pirenne, Christophe ULg

in Contrepoint (1992), 1

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See detailMonitoring of erythropoiesis by serum transferrin receptor levels in a case of chronic lymphocytic leukaemia and pure red cell aplasia treated with ciclosporin.
Elira-Dokekias, A.; R'Zik, Samir ULg; Beguin, Yves ULg et al

in Nouvelle Revue Française d'Hématologie (1992), 34(3), 257-8

The authors present the case of a patient with chronic lymphocytic leukaemia complicated by pure red cell aplasia. Successful treatment with ciclosporin was facilitated by assay of serum transferrin ... [more ▼]

The authors present the case of a patient with chronic lymphocytic leukaemia complicated by pure red cell aplasia. Successful treatment with ciclosporin was facilitated by assay of serum transferrin receptor, which demonstrated a prompt and sustained response of marrow erythropoiesis to this therapy. [less ▲]

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See detailELISA test, a new method to detect and quantify isoproturon in soil.
Liegeois, Eric; Dehon, Yves; De Brabant, Bernard et al

in Science of the Total Environment (1992), 123/124

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See detailA novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.
Bours, Vincent ULg; Burd, P. R.; Brown, K. et al

in Molecular & Cellular Biology (1992), 12(2), 685-95

A Rel-related, mitogen-inducible, kappa B-binding protein has been cloned as an immediate-early activation gene of human peripheral blood T cells. The cDNA has an open reading frame of 900 amino acids ... [more ▼]

A Rel-related, mitogen-inducible, kappa B-binding protein has been cloned as an immediate-early activation gene of human peripheral blood T cells. The cDNA has an open reading frame of 900 amino acids capable of encoding a 97-kDa protein. This protein is most similar to the 105-kDa precursor polypeptide of p50-NF-kappa B. Like the 105-kDa precursor, it contains an amino-terminal Rel-related domain of about 300 amino acids and a carboxy-terminal domain containing six full cell cycle or ankyrin repeats. In vitro-translated proteins, truncated downstream of the Rel domain and excluding the repeats, bind kappa B sites. We refer to the kappa B-binding, truncated protein as p50B by analogy with p50-NF-kappa B and to the full-length protein as p97. p50B is able to form heteromeric kappa B-binding complexes with RelB, as well as with p65 and p50, the two subunits of NF-kappa B. Transient-transfection experiments in embryonal carcinoma cells demonstrate a functional cooperation between p50B and RelB or p65 in transactivation of a reporter plasmid dependent on a kappa B site. The data imply the existence of a complex family of NF-kappa B-like transcription factors. [less ▲]

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See detailUne question de génétique : wallon "tchawe-sori" et français "chauve-souris"
Boutier, Marie-Guy ULg

in Travaux de linguistique et de philologie (1992), 30

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See detailSubcutaneous erythropoietin for treatment of refractory anemia in hematologic disorders. Results of a phase I/II clinical trial.
Cazzola, M.; Ponchio, L.; Beguin, Yves ULg et al

in Blood (1992), 79(1), 29-37

We have used recombinant human erythropoietin (rHuEPO) in a phase I/II clinical trial to evaluate its ability to reverse refractory anemia in hematologic disorders. rHuEPO was administered subcutaneously ... [more ▼]

We have used recombinant human erythropoietin (rHuEPO) in a phase I/II clinical trial to evaluate its ability to reverse refractory anemia in hematologic disorders. rHuEPO was administered subcutaneously 5 days per week at escalating doses (50 to 150 U/kg per day). The aim of treatment was a hemoglobin (Hb) level greater than or equal to 10 g/dL without blood transfusion. Of 25 patients treated, 17 were evaluable, most of them with a regular need for transfusion. Eight of these had lymphoproliferative disorders (three cases of malignant lymphoma and five of monoclonal gammopathy) and were exposed to cytotoxic therapy. The other nine patients had hematopoietic stem cell disorders (four cases of myelodysplastic syndrome, three of idiopathic myelofibrosis, and two of chronic myelogenous leukemia). All patients with lymphoproliferative disorder had serum EPO levels inappropriately low for the degree of anemia, while patients with stem cell disorder showed variable values. Erythroid marrow activity was inadequate in all cases. Seven of eight patients with lymphoproliferative disorder responded to treatment maintaining Hb above 10 g/dL without transfusion. The median dose of rHuEPO required for correction of anemia was 75 U/kg. In four cases response was maintained with 50 U/kg, three times per week. There was no complete response among patients with hematopoietic stem cell disorder, although transfusion requirement was eliminated or reduced in four cases. Four patients developed functional iron deficiency during rHuEPO treatment and required iron supplementation to obtain response. Aggravation of splenomegaly was observed in two cases of myeloproliferative disorder. We conclude that: (1) subcutaneous administration of rHuEPO can be effective and safe in patients with lymphoproliferative disorder exposed to chemotherapy and showing inappropriate EPO response to anemia; (2) this is less likely in hematopoietic stem cell disorders, although favorable responses may be observed in occasional patients; and (3) functional iron deficiency as a cause of nonresponse to rHuEPO is frequent also in nonrenal anemia. [less ▲]

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See detailIntraoperative cytokines production during orthotopic liver transplantation
Pirenne, J.; Noizat-Pirenne, F.; De Groote, D. et al

in Transplant International : Official Journal of the European Society for Organ Transplantation (1992), 5(Suppl 1), 631-635

In summary, we established that a significant production of the monokines interleukin-6, tumor necrosis factor apha, and interleukin-1 occurred during orthotopic liver transplantation whereas the ... [more ▼]

In summary, we established that a significant production of the monokines interleukin-6, tumor necrosis factor apha, and interleukin-1 occurred during orthotopic liver transplantation whereas the lymphokines interferon gamma and interleukin-2 were not detected. Levels of interleukin-6 reached their maximum values before and especially at the end of the anhepatic phase. They remained high after the anhepatic phase, i. e. after reperfusion of the new livers. Tumor necrosis factor alpha and interleukin-1 reached their maximum values after the anhepatic phase. Not only were interleukin-6, tumor necrosis factor alpha, and interleukin-1 present in the serum but they could also be detected in the bile produced by these new livers. Mechanisms of monokine production during orthotopic liver transplantation is multifactorial in origin and further studies will have to evaluate the relative contribution of the various factors involved. The possibility of an association between peroperative monokines and transplant outcome and their potential clinical implication will have to be elucidated. [less ▲]

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See detailFrom Monroe to Moreau: An analysis of face naming errors
Brédart, Serge ULg; Valentine, T.

in Cognition (1992), 45

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See detailElisa Test, A New Method To Detect And Quantify Isoproturon In Soil
Liegeois, E.; Dehon, Y.; Debrabant, B. et al

in Science of the Total Environment (1992), 123

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See detailEvidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis.
Nusgens, Betty ULg; Verellen-Dumoulin, C.; Hermanns-Le, Trinh ULg et al

in Nature Genetics (1992), 1(3), 214-7

Ehlers-Danlos (ED) syndrome type VII is characterized by the accumulation of collagen precursors in connective tissues. ED VII A and B are caused by mutations in the genes of alpha 1 and alpha 2 collagen ... [more ▼]

Ehlers-Danlos (ED) syndrome type VII is characterized by the accumulation of collagen precursors in connective tissues. ED VII A and B are caused by mutations in the genes of alpha 1 and alpha 2 collagen I which result in the disruption of the cleavage site of procollagen I N-proteinase. The existence of ED VII C in humans has been hypothesized on the basis of a disorder in cattle and sheep related to the absence of the enzyme. We now present evidence for the existence of this disease in humans, characterized by skin fragility, altered polymers seen as hieroglyphic pictures with electron microscopy, accumulation of p-N-alpha 1 and p-N-alpha 2 collagen type I in the dermis and absence of processing of the p-N-I polypeptides in fibroblast cultures. [less ▲]

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See detailCalcul des flux souterrains échangés entre le Canal Albert, la Meuse et sa plaine alluviale de Monsin à Lanaye
Dassargues, Alain ULg

in Annales de la Société Géologique de Belgique (1992), 115(1), 63-75

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See detailVoies nouvelles pour l'enseignement de la géographie dans le secondaire
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (1992), (28), 19-24

After having identified the main difficulties met by the teaching of geography in secondary schools, this article proposes tracks for a renewal. Firstly, these tracks deal with objectives : a geographical ... [more ▼]

After having identified the main difficulties met by the teaching of geography in secondary schools, this article proposes tracks for a renewal. Firstly, these tracks deal with objectives : a geographical education for all - that means the ability to understand the spatial dimensions of a problem and this at different scales. Secondly, they are concerned that we whish to focus back on a global geography that attempts to understand territories in their diverse dimensions. Finally, they deal with teaching methods by introducing above all a coherent methodology that embraces the stages of the learning of facts and of spatial "ensembles" and which integrates the scientific approach. [less ▲]

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See detailA gel retardation assay system for studying protein binding to simple repetitive DNA sequences.
Maueler, W.; Muller, Marc ULg; Kohne, A. C. et al

in Electrophoresis (1992), 13(1-2), 7-10

Simple repetitive DNA sequences have been regarded as mere "junk" present in all eukaryotic genomes. In fact, mixed simple repeat (gt)n(ga)m sequences are present in major histocompatibility complex MHC ... [more ▼]

Simple repetitive DNA sequences have been regarded as mere "junk" present in all eukaryotic genomes. In fact, mixed simple repeat (gt)n(ga)m sequences are present in major histocompatibility complex MHC-DRB genes for long evolutionary times, including such distant animals as artiodactyla and man. We describe herein an unsophisticated method which reveals that at least certain simple repetitive (gt)n(ga)m sequences bind nuclear proteins and show characteristics of a specific DNA-protein interaction via gel retardation. [less ▲]

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See detailEvaluatie van de nieuwe dopamine-agonist CV 205-502 in de behandeling van prolactinomen
Verhelst, J.; Abs, R.; Beckers, Albert ULg et al

in Acta Antwerpiensia (1992), 9

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See detailMeasuring Technical Efficiency in European Railways: A Panel Data Approach
Gathon, Henry-Jean ULg; Perelman, Sergio ULg

in Journal of Productivity Analysis (1992), 3

We estimate a factor requirement frontier for European railways using a panel data approach in which technical efficiency is assumed to be endogencously determined. This approach has two main outcomes. On ... [more ▼]

We estimate a factor requirement frontier for European railways using a panel data approach in which technical efficiency is assumed to be endogencously determined. This approach has two main outcomes. On one hand, it allows the identification of factors influencing technical efficiency, and on the other hand, it allows the estimation of alternative efficiency indicators free of these influences. In the case under study, a particular attention is devoted to an autonomy indicator representing the managerial freedom, with respect to public authorities, experienced by firms, that appears to be positively correlated with technical efficiency. [less ▲]

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See detailIntérêts et procédure d'ordre, obs. sous comm. Charleroi, 6 novembre 1991
Biquet, Christine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1992)

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See detailInverse modulation of steady-state messenger RNA levels of two non-integrin laminin-binding proteins in human colon carcinoma.
Castronovo, Vincenzo ULg; Campo, E.; van den Brule, F. A. et al

in Journal of the National Cancer Institute (1992), 84(15), 1161-9

BACKGROUND: Interactions between cells and the basement membrane glycoprotein laminin are altered during colon cancer progression. Colon carcinoma and normal mucosa cells express a variety of laminin ... [more ▼]

BACKGROUND: Interactions between cells and the basement membrane glycoprotein laminin are altered during colon cancer progression. Colon carcinoma and normal mucosa cells express a variety of laminin-binding proteins, including the 67-kd laminin receptor (67 LR) and a 31-kd human laminin-binding protein (HLBP31) homologous to the 31-kd human IgE-binding protein/galactoside-binding lectin. PURPOSE: To investigate whether various laminin-binding proteins are differentially expressed in human colon carcinoma, we studied messenger RNA (mRNA) levels of the 67 LR and HLBP31 in matched tumor and adjacent normal mucosa samples from a series of 21 patients. METHODS: Total cellular RNA from tumor and normal mucosa was isolated and analyzed by Northern and slot blot hybridization. In addition, HLBP31 protein levels were assessed by the immunoblot technique. Quantitative laminin affinity chromatography was also used to measure the synthesis of HLBP31 protein in five human cancer cell lines. RESULTS: The steady-state mRNA level of HLBP31 was downregulated (i.e., decreased) in 18 of 21 human colon carcinomas compared with the level in their corresponding normal colonic mucosa. On average, the level of HLBP31 mRNA was decreased 50% +/- 30% (+/- SD) in the colon cancers. The mean ratio of colon cancer HLBP31 mRNA to adjacent normal mucosa HLBP31 mRNA was twofold lower in primary tumors of patients with metastases (0.3 +/- 0.2 SD) than in primary tumors of patients free of metastatic lesions (0.6 +/- 0.2 SD). The differences between the two groups of patients were statistically significant (P less than .05, Wilcoxon-Mann-Whitney test). We have previously shown that the ratio of colon cancer 67 LR mRNA to corresponding normal mucosa 67 LR mRNA was increased in the same patient population. When the two ratios (ratio of cancer to normal HLBP31 mRNA and ratio of cancer to normal 67 LR mRNA) were compared, HLBP31 mRNA/67 LR mRNA was significantly lower (P less than .05) in primary tumors with metastases (mean +/- SD, 0.3 +/- 0.2) than in primary cancers without metastases (mean +/- SD, 0.7 +/- 0.5). The steady-state level of HLBP31 mRNA was directly correlated with the amount of HLBP31 protein in both colon tissue samples and human cancer cell lines. CONCLUSION: HLBP31 mRNA expression in colon cancer tissues is modulated inversely to that of 67 LR mRNA expression. The down-regulation of HLBP31 appears to be associated with the metastatic capabilities of colon cancer cells. IMPLICATIONS: Prospective studies on a large cohort should determine if the systematic detection of HLBP31 and 67 LR protein and/or mRNA can be a valuable adjunct in the prognostic evaluation of primary colon cancers. [less ▲]

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See detail"'Le Roi Renaud in Wallonia': From Cross-Cultural to Cultural-Specific Meaning
Peere, Isabelle ULg

in ARV: Scandinavian Yearbook of Folklore (1992), 48

A cross-cultural approach to the records from Wallonia of this European ballad type in structural and multi-disciplinary perspective underscoring its essential meaning and possible emphases in regional ... [more ▼]

A cross-cultural approach to the records from Wallonia of this European ballad type in structural and multi-disciplinary perspective underscoring its essential meaning and possible emphases in regional and individual contexts [less ▲]

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See detailMri-Pathological Correlations in Acute Traumatic Central Cord Syndrome: Case Report
Martin, Didier ULg; Schoenen, Jean ULg; Lenelle, Jacques ULg et al

in Neuroradiology (1992), 34(4), 262-6

Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who ... [more ▼]

Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who died 60 h later from heart failure. T2-weighted MRI showed a central hyperintense area at C3-4. There were disc protrusions, but no vertebral fracture or displacement. Histopathology disclosed severe axonal swelling and oedema in the dorsolateral fasciculi and, to a lesser degree, in the dorsal columns. In addition, an area of recent necrosis was found in the right anterior horn at C4-5. These findings suggest that the pathological hallmark of typical ATCCS is mechanical axonal disruption at a segmental level, but that more severe trauma may be accompanied by tissue destruction. [less ▲]

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See detailDopaminergic function in panic disorder: comparison with major and minor depression.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Biological Psychiatry (1992), 32(11), 1004-11

Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine ... [more ▼]

Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-matched with nine major depressive, and nine minor depressive inpatients. The three groups differed significantly in their mean GH peak response: 5.29 +/- 2.75 ng/ml in major depressives, 26.27 +/- 12.71 ng/ml in minor depressives, and 37.28 +/- 10.58 ng/ml in panics, with a significantly higher response in panic than in either minor or major depressive patients. These results support dopaminergic overactivity in panic disorder as compared with major and minor depression. [less ▲]

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See detailLocation and Characterization of the Bovine Herpesvirus Type 4 Thymidine Kinase Gene; Comparison with Thymidine Kinase Genes of Other Herpesviruses
Lomonte, P.; Bublot, M.; Pastoret, Paul-Pierre ULg et al

in Archives of Virology (1992), 127(1-4), 327-37

The location and nucleotide sequence of the bovine herpesvirus type 4 (BHV-4) thymidine kinase (TK) gene was determined. The coding region of the TK gene is 1335 nucleotides long and corresponds to a ... [more ▼]

The location and nucleotide sequence of the bovine herpesvirus type 4 (BHV-4) thymidine kinase (TK) gene was determined. The coding region of the TK gene is 1335 nucleotides long and corresponds to a polypeptide of 445 amino acids. Comparison of TK amino acid sequences of BHV-4 and 16 herpesvirus TKs reveals a greater homology to those of the gammaherpesviruses EBV and specially HVS, than to those of alphaherpesviruses. The open reading frames detected in the vicinity of TK gene were homologous to the corresponding ones in other herpesviruses. [less ▲]

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See detailFacilitation of Responses to Motor Cortex Stimulation: Effects of Isometric Voluntary Contraction
Maertens De Noordhout, Alain ULg; PEPIN, Jean-Louis ULg; GERARD, Pascale ULg et al

in Annals of Neurology (1992), 32(3), 365-70

In 7 normal subjects we compared the facilitatory effect of isometric contraction of the tibialis anterior on the size of electromyographic responses evoked in this muscle by electric stimuli applied over ... [more ▼]

In 7 normal subjects we compared the facilitatory effect of isometric contraction of the tibialis anterior on the size of electromyographic responses evoked in this muscle by electric stimuli applied over the cervical column and by electric and magnetic percutaneous stimulation of the motor cortex. No significant difference was found between the degrees of facilitation of the responses to any of the stimuli. Using collision techniques, we also showed that the pyramidal fibers activated by spinal and cortical stimuli are the same. Facilitation induced by isometric contraction (20% maximum) was of similar or greater magnitude than that found with constant vibration of the tendon of the target muscle. In cases where vibration and contraction had equal facilitatory effects, there was no further facilitation of the responses when both conditions were applied together. These findings indicate that the facilitatory effect of isometric contraction of the target muscle essentially originates at a spinal level rather than in the motor cortex. [less ▲]

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See detailLifetimes in Fe II and the solar abundance of iron
Hannaford, P.; Lowe, R. M.; Grevesse, Nicolas ULg et al

in Astronomy and Astrophysics (1992), 259

New atomic lifetimes have been determined for eight quartet (z 4D, z 4F) levels and ten sextet (z 6D, z 6F, z 6P) levels in Fe II and the results for seven of these levels have been combined with existing ... [more ▼]

New atomic lifetimes have been determined for eight quartet (z 4D, z 4F) levels and ten sextet (z 6D, z 6F, z 6P) levels in Fe II and the results for seven of these levels have been combined with existing experimental branching fractions to obtain a revised set of log gf-values for 15 solar lines in Fe II. The new log gf data are used together with equivalent widths determined from the Liege solar atlas to derive a value for the iron photospheric abundance: 7.48 +/- 0.04, which is consistent with the currently accepted meteoritic result, 7.51 +/- 0.01. The results are compared with the atomic lifetime data, log gf data and solar analyses used in three other recent solar abundance determinations based on Fe II lines. [less ▲]

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See detailGalactose Alpha 1-3 Galactose and Anti-Alpha Galactose Antibody in Normal and Pathological Pregnancies
Christiane, Y.; Aghayan, M.; Emonard, H. et al

in Placenta (1992), 13(5, Sep-Oct), 475-87

The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor ... [more ▼]

The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor cells, we have examined the possibility of their expression on human trophoblastic cells at different stages of placental implantation and in various pregnancy-associated conditions. Using immunohistochemical methods, Gal alpha 1-3 Gal was demonstrated on interstitial and vascular trophoblast during pregnancy. For villous trophoblast, the staining disappeared in second trimester pregnancies. The density of staining for Gal alpha 1-3 Gal was increased in highly invasive trophoblast (mole and choriocarcinoma) and decreased in poorly invasive specimens (spontaneous abortion, XO monosomia). No cells displaying Gal alpha 1-3 Gal at their surface were identified in some segments of spiral arteries from pre-eclamptic women. The anti-Gal antibody titer increased in the first trimester of pregnancy and in the sera of pre-eclamptic and eclamptic patients. These findings suggest that Gal alpha 1-3 Gal residues could be considered as markers for trophoblast invasive capacity and that the binding of maternal anti-Gal antibodies to the trophoblast could contribute to limit trophoblastic invasion and thus participate to the immunological control of implantation. [less ▲]

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See detailUn index sélectif d’un texte philosophique. Husserl, Die Idee der Phänomenologie
Evrard, Etienne ULg; Purnelle, Gérald ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1992)

To assist the content analysis of a philosophical text, we have created a method of constituting both a selective index reduced to philosophically significant words and several frequency lists. We have ... [more ▼]

To assist the content analysis of a philosophical text, we have created a method of constituting both a selective index reduced to philosophically significant words and several frequency lists. We have applied this method to Die Idee der Phenomenologie where Husserl explains for the first time his theory of the phenomenological reduction and of the constitution of the objects in the conscience. The results proved to be valuable for the philosophical interpretation. [less ▲]

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See detailNew data concerning the functional organization of the mammalian cell nucleolus: detection of RNA and rRNA by in situ molecular immunocytochemistry.
Thiry, Marc ULg

in Nucleic Acids Research (1992), 20(23), 6195-200

We have investigated the fine spatial distribution of RNA and rRNA within the Ehrlich tumor cell nucleolus by in situ hybridization with a biotin-labeled probe and by two new strategies, the polyadenylate ... [more ▼]

We have investigated the fine spatial distribution of RNA and rRNA within the Ehrlich tumor cell nucleolus by in situ hybridization with a biotin-labeled probe and by two new strategies, the polyadenylate nucleotidyl transferase-immunogold technique and immuno-labeling with anti-RNA antibodies. Besides the presence, as expected, of RNA and rRNA in the granular component and the dense fibrillar component, we show, for the first time, significant label over all the fibrillar centers of the nucleoli. When RNA and DNA were detected simultaneously on the same sections, only the fibrillar centers were positive for both. These results throw light on the controversial subject of the precise location of transcribing rRNA genes within the nucleolus. The fibrillar centers, and not the dense fibrillar component, should thus be the site of rRNA synthesis. [less ▲]

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See detailReversed-Phase Hptlc Densitometric Evaluation of Fraxin in Fraxinus Excelsior Leaves
Poukens-Renwart, P.; Tits, Monique ULg; Wauters, Jean-Noël ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1992), 10(10-12, Oct-Dec), 1089-91

The present work describes a rapid and selective assay for fraxin based on its characteristic fluorescent properties by densitometry on reversed-phase HPTLC plates. Two chromatographgic procedures ... [more ▼]

The present work describes a rapid and selective assay for fraxin based on its characteristic fluorescent properties by densitometry on reversed-phase HPTLC plates. Two chromatographgic procedures (Silicagel and RP 18) have been assessed and the results compared to those obtained by reversed-phase HPLC on ODS-silica. The amount of fraxin found in six commercial batches of Fraxinus excelsior leaves ( based on dry weight) ranged from 0.1 to 0.2%. [less ▲]

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See detailImpaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections.
Moutschen, Michel ULg; Scheen, André ULg; Lefebvre, Pierre ULg

in Diabète & Métabolisme (1992), 18(3), 187-201

The reasons why diabetic patients present with an increased susceptibility to frequent and protracted infections remain unclear. The virtual absence of epidemiological studies of the independent risk ... [more ▼]

The reasons why diabetic patients present with an increased susceptibility to frequent and protracted infections remain unclear. The virtual absence of epidemiological studies of the independent risk factors involved contrasts with the multitude of in vitro models focused on the metabolism and function of immune cells from diabetic patients. This review analyzes some of these models and their clinical relevance. The different levels of diabetes pathogenesis: genetic (Type 1), autoimmune (Type 1) and metabolic (Type 1 and Type 2) are responsible for immune abnormalities demonstrated in in vitro models. The participation of genetic and autoimmune factors has been mainly characterized on T lymphocyte function. The B8 DR3 haplotype is associated with several minor immunologic abnormalities in vitro. However, the high frequency of this haplotype in healthy individuals argues against its involvement in significant defects of antimicrobial immunity. Genetic deficiency of C4, present in 25% of Type 1 diabetic patients could, on the other hand, be responsible for opsonization defects against encapsulated pathogens. Several immunological abnormalities related to the autoimmune process preceding the onset of Type 1 diabetes mellitus, such as the depletion of memory CD4+ cells and the defective natural killer activity could transiently impair host defences against viral diseases. Several in vitro functional defects of the immune system have been correlated with the metabolic control of diabetic patients. This suggests the involvement of insulinopenia in some of the abnormalities observed. Insulinopenia-induced enzymatic defects have often been proposed to inhibit energy-requiring functions of phagocytes and lymphocytes. However, the relevance of this mechanism could be confined to patients with extremely severe metabolic abnormalities. The importance of systemic consequences of insulinopenia such as hyperglycaemia and ketosis has also been addressed. Usually, the defects induced in vitro by these factors are slight and require supraphysiologic concentrations of glucose or ketone bodies. Recent studies have shown abnormalities of signal transduction mechanisms in which insulinopenia itself and other factors such as circulating immune complexes could be involved. Despite numerous controversies, many in vitro studies of the immune cells of diabetic patients have demonstrated significant defects which bear quantitative similarities with abnormalities described in other immunodeficiency syndromes. Furthermore, several mechanisms have been proposed to link the different defects observed with the specific infections encountered in diabetic patients. [less ▲]

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See detailWilson Harris's Carnival: Through and Beyond Demarcations
Pagnoulle, Christine ULg

in Journal of West Indian Literature (1992), 5(1-2), 75-84

There is something definitely messianic about Wilson Harris' fiction. The present article explores how transgressions of a number of conventions that are part of the 'tautology of power' function in his ... [more ▼]

There is something definitely messianic about Wilson Harris' fiction. The present article explores how transgressions of a number of conventions that are part of the 'tautology of power' function in his novel Carnival. [less ▲]

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See detailMolecular modeling of the amphipathic helices of the plasma apolipoproteins.
Brasseur, Robert ULg; Lins, Laurence ULg; Vanloo, B. et al

in Proteins (1992), 13(3), 246-57

In this paper we propose a classification of the amphipathic helical repeats occurring in the plasma apolipoprotein sequences. It is based upon the calculation of the molecular hydrophobicity potential ... [more ▼]

In this paper we propose a classification of the amphipathic helical repeats occurring in the plasma apolipoprotein sequences. It is based upon the calculation of the molecular hydrophobicity potential around the helical segments. The repeats were identified using a new autocorrelation matrix, based upon similarities of hydrophobic and hydrophilic properties of the amino acid residues within the apolipoprotein sequences. The helices were constructed by molecular modeling, the molecular hydrophobicity potential was calculated, and isopotential contour lines drawn around the helices yielded a three-dimensional visualization of the hydrophobicity potential. Two classes of apolipoproteins could be differentiated by comparing the hydrophobic angles obtained by projection of the isopotential contour lines on a plane perpendicular to the long axis of the helix. The isopotential contour lines around apo AI, AIV, and E are more hydrophilic than hydrophobic, whereas they are of similar intensity for apo AII, CI, and CIII. In both cases discoidal lipid-protein complexes are generated, with the amphipathic helices around the edge of the lipid core. The long axis of the helices is oriented parallel to the phospholipid acyl chains and the hydrophilic side of the helix toward the aqueous phase. As a result of the differences in hydrophobicity potential, the contact between the hydrophobic side of the helices and the phospholipid acyl chains is larger for apo AII, CI, and CIII than for the other apolipoproteins. This might account for the greater stability of the discoidal complexes generated between phospholipids and these apoproteins. [less ▲]

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See detailAérosolthérapie : revue des substances thérapeuthiques à impacts bénéfiques pour la fonction pulmonaire
Genicot, Bruno; Mouligneau, Frédéric; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1992), 136

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See detailIntroductions et Réintroductions de mammifères en Belgique: Bilan et réflexions
Libois, Roland ULg

in Annales biologiques du Centre (1992), 4

During the last century, five mammal species were introduced into Belgium. One of them, the wild sheep, was introduced by hunters. Illicite releases are responsable of the presence of the coypu in many ... [more ▼]

During the last century, five mammal species were introduced into Belgium. One of them, the wild sheep, was introduced by hunters. Illicite releases are responsable of the presence of the coypu in many localities and the Siberian chipmunk in the vicinity of Brussels. The muskrat, widespread all over the country, the raccoon and some coypus are invaders from rearing facilities. Population reinforcements of game species (brown hare, red deer, wild boar...) are still frequent and are made without any control measures. Sometimes, hybrids between domestic pigs and wild boars are released in the wild by hunters. No project is officially supported to reintroduce extinct species. In some conservationist groups, however, there is some concern in doing something in favor of the otter and the beaver. [less ▲]

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See detailVers un apprentissage semi-autonome en français langue de spécialité (seconde partie)
Vanden Berghe, Kristine ULg; Slootmaekers, An; Sanctobin, Véronique et al

in Romaneske (1992), 17(3), 53-62

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See detailRelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
Ryseck, R. P.; Bull, P.; Takamiya, M. et al

in Molecular & Cellular Biology (1992), 12(2), 674-84

We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional ... [more ▼]

We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional activation analysis of GAL4-RelB fusion proteins in yeast cells reveals that RelB contains in its C-terminal 180 amino acids a transcriptional activation domain. The N-terminal part including the region of similarity with the Rel family shows no detectable transcriptional activity. RelB does not bind with high affinity to NF-kappa B sites, but heterodimers between RelB and p50-NF-kappa B do bind to different NF-kappa B-binding sites with a similar affinity to that shown by p50-NF-kappa B homodimers. However, RelB/p50-NF-kappa B heterodimers, in contrast to p50-NF-kappa B homodimers, transactivate transcription of a promoter containing a kappa B-binding site. [less ▲]

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See detailLes champs électromagnétiques ELF ont-ils un effet sur la santé? Revue de la littérature
Crasson, Marion ULg; Timsit-Berthier, Martine; Legros, Jean-Jacques ULg

in Psychologie Médicale (1992), 24(11), 1205-1215

De nombreuses études ont été entreprises les dernières décénnies sur les effets des champs électromagnétiques de très basse fréquence (TBF ou ELF). Les rapports publiés sont tantôt optimistes tantôt ... [more ▼]

De nombreuses études ont été entreprises les dernières décénnies sur les effets des champs électromagnétiques de très basse fréquence (TBF ou ELF). Les rapports publiés sont tantôt optimistes tantôt pessimistes. Les auteurs passent en revue les recherches épidémiologiques et expérimentales effectuées chez l'homme avant d'envisager une hypothèse explicative des effets observés, en relation avec le rôle joué par la glande pinéale [less ▲]

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See detailDam treatment with insulin-like growth factor-I monoclonal antibodies induce an alteration of fetal development
Renaville, Robert ULg; Devolder, Anne; Sneyers, Myriam et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1992), 100

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See detailPh. Vendrix (éd.), « L’opéra comique en France au XVIIIe siècle »
Pirenne, Christophe ULg

in Contrepoint (1992), 1

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See detailDe internationale organisatie van de strijd tegen het witwassen van geld
Flore, Daniel ULg

in Panopticon : Tijdschrift voor Strafrecht, Criminologie en Forensisch Welzijnswerk (1992)

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See detailHuman papillomavirus type 33 upstream regulatory elements can control gene expression in human cervical keratinocytes
Lauricella-Lefèbvre, M. A.; Rentier, Bernard ULg; Piette, Jacques ULg

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1992), 100

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See detailL'analyse structurale semi-rigide: définition, domaine et mode d'application
Jaspart, Jean-Pierre ULg; Maquoi, René ULg

in Infrastructuur in het Leefmilieu (1992), n°5/92

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See detailCompte rendu de J.L. NELSON, Politics and Ritual in Early medieval Europe
Marchandisse, Alain ULg

in Moyen Age (Le) (1992), 98

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See detailVaricella-zoster virus: an ultrastructural study of the assembly phases
Schoonbroodt, Sonia; Piette, Jacques ULg; Rentier, Bernard ULg

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1992), 100

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See detailFibromuscular dysplasia of the external iliac artery. A case report.
ADANT, JEAN-PHILIPPE; SAKALIHASAN, Natzi ULg; Dekoster, Guy ULg et al

in Vascular Surgery (1992), 26

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See detailAnalytical linear numerical stability conditions for an anisotropic 3 D advection-diffusion equation
Beckers, Jean-Marie ULg

in SIAM Journal on Numerical Analysis (1992), 29(3), 701-713

A one-timestep scheme for advective-diffusive problems in three dimensions is analysed from a numerical stability point of view. Choosing a realizable general seven-point centred discretization scheme ... [more ▼]

A one-timestep scheme for advective-diffusive problems in three dimensions is analysed from a numerical stability point of view. Choosing a realizable general seven-point centred discretization scheme, the amplification factor of the von Neumann method is calculated, and necessary and sufficient stability conditions for the general one-dimensional problem are retrieved. A similar analysis then leads to necessary conditions for the three-dimensional case. It is proved that the conditions obtained are also sufficient for an explicit N-dimensional case. Generalization is made to uncentered schemes and some classical results are recovered or corrected. For practical use, some miminum implicit factors necessary for stability are calculated and it is shown that the inspection of one-dimensional problems to get stability conditions can be tricky. [less ▲]

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See detailReplicon typing of virulence plasmids of enterotoxigenic Escherichia coli isolates from cattle
Mainil, Jacques ULg; Bex, F.; Dreze, P. et al

in Infection and Immunity (1992), 60

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See detailThe 1985 chlorine and fluorine inventories in the stratosphere based on atmos observations at 30-degrees north latitude
Zander, Rodolphe ULg; Gunson, Michael R.; Farmer, Crofton B. et al

in Journal of Atmospheric Chemistry (1992), 15(2), 171-186

The set of high-resolution infrared solar observations made with the Atmospheric Trace Molecule Spectroscopy (ATMOS) - Fourier transform spectrometer from onboard Spacelab 3 (30 April-1 May 1985) has been ... [more ▼]

The set of high-resolution infrared solar observations made with the Atmospheric Trace Molecule Spectroscopy (ATMOS) - Fourier transform spectrometer from onboard Spacelab 3 (30 April-1 May 1985) has been used to evaluate the total budgets of the odd chlorine and fluorine chemical families in the stratosphere. These budgets are based on volume mixing ratio profiles measured for HCl, HF, CH3Cl, ClONO2, CCl4, CCl2F2, CCl3F, CHClF2, CF4, COF2, and SF6, near 30-degrees north latitude. When including realistic concentrations for species not measured by ATMOS, i.e., the source gases CH3CCl3, and C2F3Cl3 below 25 km, and the reservoirs ClO, HOCl and COFCl between 15 and 40 km (five gases actually measured by other techniques), the 30-degrees-N zonal 1985 mean total mixing ratio of chlorine, Cl, was found to be equal to (2.58 +/- 0.10) ppbv (parts per billion by volume) throughout the stratosphere, with no significant decrease near the stratopause. The results for total fluorine indicate a slight, but steady, decrease of its volume mixing ratio with increasing altitude, around a mean stratospheric value of (1.15 +/- 0.12) ppbv. Both uncertainties correspond to one standard deviation. These mean springtime 1985 stratospheric budgets are commensurate with values reported for the tropospheric Cl and F concentrations in the early 1980s, when allowance is made for the growth rates of their source gases at the ground and the time required for tropospheric air to be transported into the stratosphere. The results are discussed with emphasis on conservation of fluorine and chlorine and the partitioning among source, sink, and reservoir gases throughout the stratosphere. [less ▲]

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See detailMatériaux pour enseigner l'histoire des femmes
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1992), 42e année(n°3), 21-23

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See detailRéCoDA, un réseau de bibliothèques.
Pochet, Bernard ULg

in Cahiers de la Documentation = Bladen voor Documentatie (1992), 46(4), 184-185

Cet article présente le réseau RéCoDA. Le réseau RéCoDA est un réseau coopératif de bibliothèques (établissements d'enseignement secondaire et supérieur en Communauté française de Belgique) et d ... [more ▼]

Cet article présente le réseau RéCoDA. Le réseau RéCoDA est un réseau coopératif de bibliothèques (établissements d'enseignement secondaire et supérieur en Communauté française de Belgique) et d'utilisateurs (étudiants, enseignants et bibliothécaires) crée en avril 1991. Le Centre serveur du réseau, situé à Gembloux, réalise la réunion des catalogues informatisés des bibliothèques coopérantes. Ce catalogue commun est accessible par Internet. Tous les documents signalés se trouvent dans au moins une des bibliothèques coopérantes et peuvent être consultés sur place ou expédiés par le prêt inter-bibliothèques. Cette accessibilité des documents fait de RéCoDA une bibliothèque virtuelle présente chez tous ses utilisateurs. Ses objectifs sont d'améliorer l'utilisation des bibliothèques existantes en les ouvrant aux utilisateurs de toutes les écoles, de permettre une didactique liée à la prise d'information tant pour les enseignants que pour les étudiants et de promouvoir par la pratique un esprit coopératif de partage de l'information. [less ▲]

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See detailMourning and Guilt among Greek Women having repeated abortions
Naziri, Despina ULg; Tzavaras, Th.

in Omega : Journal of Death and Dying (1992), 26(2), 137-144

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See detailAntibodies to varicella-zoster virus modulate antigen distribution but fail to induce viral persistence in vitro.
Sadzot-Delvaux, Catherine ULg; Marc, Philippe; Lebon, Linda et al

in Journal of Virology (1992), 66(12), 7499-504

Varicella-zoster virus (VZV) persists in human sensory ganglia. One of the hypotheses to explain the induction or the maintenance of VZV latency is that it could be promoted by the immune response itself ... [more ▼]

Varicella-zoster virus (VZV) persists in human sensory ganglia. One of the hypotheses to explain the induction or the maintenance of VZV latency is that it could be promoted by the immune response itself. It is known that in the case of viruses which bud off the infected cell membrane, virus-specific antibodies can induce antigenic modulation, i.e., spatial redistribution of viral antigens and modulation of their synthesis. To determine whether antigenic modulation occurs during VZV infection in vitro and could possibly be involved in viral persistence, we have grown infected cells in the presence of anti-VZV antibodies either transiently or permanently. The distribution of immune complexes and viral proteins was then analyzed. In transient immunomodulation experiments, the distribution of one or more viral antigens was modified not only in the cytoplasmic membranes but also in the cytoplasm and nucleoplasm of infected cells. When infected cells were kept permanently in the presence of antibodies, the same pattern of redistribution of immune complexes was observed and the localization of internal viral glycoproteins was significantly modified. However, antibodies did not prevent the lytic effect of infection; they altered neither the infectious virus yield nor the Western immunoblot pattern of viral proteins, suggesting that immunomodulation is not the primary effector of viral persistence. [less ▲]

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See detailCongenital sebaceous trichofolliculoma
Kharfi, M.; Fazaa, B.; Mokhtar, I. et al

in Giornale Internazionale Dermatologia Pediatrica (1992), 4(1), 33-35

We report the clinical and histological presentation of a sebaceous trichofolliculoma present on the dorsum of the nose of a 1-year-old boy. This lesion was present since birth and appears to be the forst ... [more ▼]

We report the clinical and histological presentation of a sebaceous trichofolliculoma present on the dorsum of the nose of a 1-year-old boy. This lesion was present since birth and appears to be the forst reported cas of a congenital sebaceous trichofolliculoma. [less ▲]

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See detailSynthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4-triazole analogues des antibiotiques b-lactamiques
Pirotte, Bernard ULg; Dive, Georges ULg; Delarge, Jacques et al

in European Journal of Medicinal Chemistry (1992), 27(3), 193-205

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See detailEnquête sur l'infestation du renard roux (Vulpes vulpes) par Echinococcus multilocularis en province de Luxembourg (Belgique)
Brochier, B.; Coppens, P.; Losson, Bertrand ULg et al

in Annales de Médecine Vétérinaire (1992), 136

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See detailA histologic study of the extracellular matrix during the development of glomerulosclerosis in murine chronic graft-versus-host disease.
Bergijk, E. C.; Munaut, Carine ULg; Baelde, J. J. et al

in American Journal of Pathology (1992), 140(5), 1147-56

The development of glomerulosclerosis was studied in murine chronic graft-versus-host disease (GvHD), which is a model for human systemic lupus erythematosus. The authors investigated the distribution ... [more ▼]

The development of glomerulosclerosis was studied in murine chronic graft-versus-host disease (GvHD), which is a model for human systemic lupus erythematosus. The authors investigated the distribution patterns of six components of the extracellular matrix (ECM), i.e., laminin, fibronectin, collagen types I, III, IV, and VI during the course of the disease. All of these ECM components except collagen type I were found in the glomeruli of normal mice, where all of them were intrinsic constituents of the mesangium. Laminin, fibronectin, and collagen type IV were also found in the glomerular capillary walls. Starting 6 weeks after the induction of GvHD and continuing at week 8, the onset of an expansion of the mesangial matrix was observed. At the same time, the amounts of laminin, fibronectin, and collagen types IV and VI increased. Ten weeks after the onset of the disease, glomerulosclerosis developed. Traces of the interstitial collagen type I were found in sclerotic glomeruli. The levels of four ECM components, i.e., collagens III, IV, VI, and laminin were markedly decreased in the sclerotic glomeruli as compared with week 8. In contrast, the amount of fibronectin in the sclerotic glomeruli increased dramatically. Immunoelectron microscopic examination showed fibronectin in the sclerotic lesions, in contrast to laminin, collagen type I, and collagen type IV. It is concluded that the sclerotic lesions in murine chronic GvHD contain fibronectin. The small amounts of the ECM components laminin, as well as collagens III, IV, and VI in the sclerotic glomeruli in GvHD, might represent remnants of mesangial material and collapsed capillary walls. These components are probably replaced by increased production and/or accumulation of collagen type I and fibronectin. [less ▲]

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See detailCLAY SEDIMENTATION IN THE JAPAN SEA SINCE THE EARLY MIOCENE - INFLUENCE OF SOURCE-ROCK AND HYDROTHERMAL ACTIVITY
Fagel, Nathalie ULg; André, Luc; CHAMLEY, H. et al

in Sedimentary Geology (1992), 80(1-2), 27-40

X-ray diffraction analyses have been carried out on 128 samples of Miocene to Quaternary sediments from ODP Sites 794, 795 and 797. Some clay fractions of samples from Site 797 have also been studied for ... [more ▼]

X-ray diffraction analyses have been carried out on 128 samples of Miocene to Quaternary sediments from ODP Sites 794, 795 and 797. Some clay fractions of samples from Site 797 have also been studied for rare earth elements and by Nd isotopic analyses. These three sites display similar lithological and clay assemblages (with dominant chlorite, illite and smectite) showing that the sedimentation was homogeneous throughout the whole Japan Sea Basin. Three mineralogical zones are recognized. The first zone (Lower Miocene sandy clay of Sites 794 and 797) is mainly composed of chlorite resulting from hydrothermal transformation of arc-derived smectite, due to sill injections during the initial oceanic spreading stage. The second zone (Lower Miocene to Lower Pliocene siliceous claystone and diatomaceous silty clay) is dominated by arc-derived smectite; the abundance of this mineral decreases upwards while illite and chlorite increase. This trend reflects a change of detrital source, from an eastern arc-derived source (epsilon(Nd)t > -3.3; variable LREE enrichment) to a western continental crust source (epsilon(Nd)t < -9.4; shale-like REE patterns); climatic modifications in the current dynamics are proposed as a cause for this change. The third zone (Upper Pliocene to Recent silty clay with minor diatom oozes) is characterized at Site 797 by increasing amounts of illite and chlorite. This reflects a more and more important western supply which is assumed to be related to tectonic rejuvenations of the Asian margin or climatic modifications affecting the alteration conditions or the current dynamics. At Sites 794 and 795, the more or less sharp supply of chlorite seems to be driven by the incipient subduction zone on the eastern margin of the Japan Sea. [less ▲]

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See detailLe désherbage mécanique, une technique d'avenir
Dardenne, J.; Dewez, G.; Vandersmissen, P. et al

in Revue de l’Agriculture = Landbouwtijdschrift (1992), 45(6), 1193-1200

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See detailLa Federation des Banques de Donnees Biogeographiques (FBDB).
Dufrêne, Marc ULg; Lebrun, Philippe; Rasmont, P.

in Mémoires de la Société Royale d'Entomologie de Belgique (1992), 35

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See detailL'autisme et la pensée du temps
Van Varenbergh, M.; Gauthier, Jean-Marie ULg

in Revue Belge de Psychanalyse (1992), 20

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See detailLa francophonie encore et toujours en question
Defays, Jean-Marc ULg

in Bulletin Francophone de Finlande (1992), (8), 3-6

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See detailDésindustrialisation et tertiairisation : quelques observations à partir du cas de Liège
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1992), LXI

To understand these two processes, a case study is proposed: Liège. The ultimate objective is to measure and identify the components of the facts

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See detailComparative study of typical neuroleptics, clozapine and newly synthesized clozapine-analogues: correlations between neurochemistry and behaviour.
Bruhwyler, J.; Liégeois, Jean-François ULg; Chleide, E. et al

in Behavioural pharmacology (1992), 3(6), 567-579

While neuroleptic therapy with classical compounds has frequently been associated with extrapyramidal side effects, clozapine has revealed an interesting antipsychotic profile without producing any ... [more ▼]

While neuroleptic therapy with classical compounds has frequently been associated with extrapyramidal side effects, clozapine has revealed an interesting antipsychotic profile without producing any clearcut motor side effects. However, some adverse reactions remained that stimulated the search for improved antipsychotic agents. The aim of this study was to characterize the behavioural and neurochemical profiles of typical neuroleptics (chlorpromazine, haloperidol), clozapine, and four newly synthesized clozapine-analogues. Affinity for dopaminergic (D1,D2), serotonergic (5-HT(2)) and cholinergic (muscarinic) receptors were measured and the ratios of these different binding affinities were determined and correlated with the behavioural effects of the drugs in a complex temporal regulation task in the dog. The four clozapine-analogues showed most of the behavioural characteristics previously described for neuroleptics and their neurochemical profile, particularly their 5-HT(2)/D2 pKi ratio, was compatible with an atypical antipsychotic effect. Among these drugs, JL5 and JL13 showed a high degree of similarity with clozapine. Like clozapine, they did not induce catalepsy and stereotypy/hyperkinesia. Moreover, other motor effects were also reduced (ataxia, akinesia, dystony). and tremor and sialorrhea were completely absent with these two molecules. [less ▲]

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See detailRoughness analysis on powders using mathematical morphology
Pirard, Eric ULg

in Acta Stereologica (1992), 11(Suppl. 1), 533-538

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See detailTuberculosis in dogs : a case report and review of the literature
Clercx, Cécile ULg; Coignoul, Freddy ULg; Jakovlevic, S. et al

in Journal of the American Animal Hospital Association (1992), 28

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See detailHémodialyse et hyperferritinémie
Paris, M.; Benoit, M. O.; Bied, A. et al

in Annales de Biologie Clinique (1992), 50(4), 251-258

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See detailObservation du comportement des participants et des éducateurs sportifs dans le cadre d’activités parascolaires, organisées pour des enfants de 8 à 10 ans
Cloes, Marc ULg; Coulonval, Nathalie; Delfosse, Catherine et al

in Revue de l'Education Physique (1992), 32(4), 189-197

Le livre blanc sur la condition physique des jeunes en Belgique (Piéron & Vrijens, 1991) a attiré l'attention sur l'existence d'un déficit d'activité motrice dans les premières tranches d'âges de la ... [more ▼]

Le livre blanc sur la condition physique des jeunes en Belgique (Piéron & Vrijens, 1991) a attiré l'attention sur l'existence d'un déficit d'activité motrice dans les premières tranches d'âges de la population de notre pays. Afin d'en limiter les effets néfastes, il est opportun que la communauté éducative offre aux enfants plus de possibilités d'engagement dans des programmes d'éducation physique et motrice. ... [less ▲]

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See detailCroissance de la productivité, rattrapage et innovation: une analyse des secteurs manufacturiers de l'OCDE
Fecher-Bourgeois, Fabienne ULg

in Economie et Prévision (1992), 102-103(1992-1/2), 117-127

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See detailCompte rendu de l'ouvrage Le pressoir mystique
George, Philippe ULg

in Moyen Age (Le) (1992)

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See detailDogmatismes sur les campus
Martiniello, Marco ULg

in Agenda Interculturel (1992), 101

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See detailGrowth hormone receptor amino-acid sequence variability
Sneyers, Myriam; Renaville, Robert ULg; Devolder, Anne et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1992), 100

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See detailLa dépendance externe de l'appareil productif de cinq pays de la CEE
Lejeune, Bernard ULg

in Cahiers Economiques de Bruxelles (1992), 133

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See detailFailure of Buserelin-Induced Medical Castration to Control Pulmonary Lymphangiomyomatosis in Two Patients
RADERMECKER, Marc ULg; Broux, R.; Corhay, Jean-Louis ULg et al

in CHEST (1992), 101(6), 1724-6

Two women, aged 44 and 29 years, respectively, were admitted to the hospital in early 1987 for recurrent pneumothorax, dyspnea and a diffuse reticulonodular pattern evidenced on the chest x-ray film. Lung ... [more ▼]

Two women, aged 44 and 29 years, respectively, were admitted to the hospital in early 1987 for recurrent pneumothorax, dyspnea and a diffuse reticulonodular pattern evidenced on the chest x-ray film. Lung biopsy confirmed LAM in both patients. Both were treated sequentially with medroxyprogesterone and a LHRH agonist (buserelin) to achieve reversible medical castration. Neither subjective nor objective improvement was noted after 13 and 5 months, respectively, of buserelin therapy (900 micrograms/day, nasal spray) despite an effective suppression of the pituitary-gonadal axis. Medroxyprogesterone also was ineffective. Buserelin thus failed to control pulmonary LAM in these two patients, in spite of effective medical castration. [less ▲]

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See detailAcidic degradation of zeolite catalysts in the course of aromatic chlorination using sulfuryl chloride
Antenucci, Diano; Delaude, Lionel ULg; Fransolet, André-Mathieu ULg et al

in Journal of Catalysis (1992), 135(1), 92-98

The structural changes of two faujasite type zeolites in the course of aromatic chlorinations by sulfuryl chloride, SO2Cl2, were investigated by X-ray powder diffraction. Both catalysts examined, the NaX ... [more ▼]

The structural changes of two faujasite type zeolites in the course of aromatic chlorinations by sulfuryl chloride, SO2Cl2, were investigated by X-ray powder diffraction. Both catalysts examined, the NaX zeolite, which promotes catenar side-chain chlorination, and the ZF520 zeolite, which promotes nuclear electrophilic chlorination, are strongly altered in the acidic reaction medium (hydrochloric acid and sulfur dioxide are evolved continually as the reaction proceeds). In the presence of residual humidity, progressive dealumination of the ZF520 catalyst occurs without destruction of the zeolite framework. It gives rise to the formation of an alum type structure, for which the molecular formula (H3O)Al(SO4)2.12 H2O has been suggested. Rapid degradation of the NaX zeolite is accompanied by the formation of sodium chloride and of the sodium aluminium sulfate hexahydrate, NaAl(SO4)2.6 H2O. These compounds indeed catalyze the side-chain chlorination of toluene by SO2Cl2. Under water exclusion, structural degradation of both zeolites is slowed down; formation of hydrated sulfates is prevented; however the efficiency of the catalysts is also reduced. [less ▲]

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See detailLa matière en suspension de la couche de surface du plateau continental nord-ouest européen. II. Teneur en métaux lourds et transfert dans la chaîne trophique
Bouquegneau, Jean-Marie ULg; Gobert, Sylvie ULg; Frankignoulle, Michel et al

in Bulletin de la Société Royale des Sciences de Liège (1992), 61

Samples of suspended matter (MS) from the North Sea have been analysed for its heavy metal content. Unexpected high levels of copper have been recorded. The Scheldt Estuary reveals to be an important ... [more ▼]

Samples of suspended matter (MS) from the North Sea have been analysed for its heavy metal content. Unexpected high levels of copper have been recorded. The Scheldt Estuary reveals to be an important source of zinc, lead and cadmium for the sea. The transfer of metals from the MS to mussels is low. [less ▲]

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See detailLe triticale en alimentation animale.
Thewis, André ULg; Leterme, Pascal

in Elevages Belges (1992), 46(7-8), 27-31

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See detailIn-vitro evaluation of drugs proposed as chondroprotective agents.
Bassleer, C.; Henrotin, Yves ULg; Franchimont, P.

in International Journal of Tissue Reactions (1992), 14(5), 231-41

Three proposed chondroprotective agents (CP), namely glucosamine sulfate (GAS), chondroitin sulfate (CS) and glycosaminoglycan-peptide complex (GP-C), were tested on differentiated human articular ... [more ▼]

Three proposed chondroprotective agents (CP), namely glucosamine sulfate (GAS), chondroitin sulfate (CS) and glycosaminoglycan-peptide complex (GP-C), were tested on differentiated human articular chondrocytes cultured in clusters. Chondrocyte productions of proteoglycans (PG), type II collagen (coll. II) and prostaglandin E2 (PGE2) were established by specific radioimmunoassays applied to the culture medium (CM) and in chondrocyte clusters (CC). Collagenolytic activity was assayed in CM. DNA synthesis, studied by measuring 3H-thymidine incorporation, was unaffected by CS and GAS. GP-C, at low concentration, stimulated DNA synthesis. GP-C, at higher doses, induced a high increase in PG and coll. II productions. GAS and CS induced a stimulatory effect limited to PG production. None of the CP tested here affected the basal PGE2 production by human chondrocytes. [less ▲]

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See detailTranslating poems: a precarious balance
Pagnoulle, Christine ULg

in Babel : Revue Internationale de la Traduction = International Journal of Translation (1992), 38(3), 139-148

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See detailHormone de croissance placentaire humaine : expression par génie génétique et relation structure-activité
Igout, Ahmed ULg; Frankenne, Francis; Scippo, Marie-Louise ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1992), 3

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See detailLes activités physiques et parascolaires. Analyse des possibilités d'application
Delfosse, Catherine; Cloes, Marc ULg; Piéron, Maurice

in Sport (1992), 139

Cette étude faisait partie d'un programme visant l'organisation d'activités physiques et sportive dans le cadre parascolaire pour les enfants fréquentant les classes de 3ème et 4ème années des écoles ... [more ▼]

Cette étude faisait partie d'un programme visant l'organisation d'activités physiques et sportive dans le cadre parascolaire pour les enfants fréquentant les classes de 3ème et 4ème années des écoles primaires de Fléron (région liégeoise). Ses objectifs étaient les suivants: (1) contrôler l'effet de la participation des enfants sur leur aptitude physique générale, sur leurs comportements moteurs spécifiques au contenu des activités et sur divers comportements moteurs sociaux; (2) identifier les facteurs influençant la participation au programme ou son abandon; (3) analyser les possibilités d'application de ce type d'action en vue de favoriser la pratique des activités physiques et sportives dans le cadre parascolaire. [less ▲]

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See detailIncidence redistributive de la privatisation des retraites
Delhausse, B.; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Revue d'Economie Financière (1992), (23), 65-79

L’objet de cet article est d’étudier l’incidence redistributive que devrait avoir la substitution partielle des pensions publiques par des pensions privées, qui favorisent les salaires et les revenus les ... [more ▼]

L’objet de cet article est d’étudier l’incidence redistributive que devrait avoir la substitution partielle des pensions publiques par des pensions privées, qui favorisent les salaires et les revenus les plus élevés relativement aux salaires et revenus les plus faibles. Dans la mesure où les pensions privées vont se développer, l’article évalue si elles ne vont pas accroître les inégalités dans les tranches d’âge les plus élevées par des simulations effectuées dans le cadre de la Belgique. [less ▲]

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See detailApplication de l'analyse CoMFA (Comparative Molecular Field Analysis) à une série de dérivés tricycliques apparentés à la clozapine
Liégeois, Jean-François ULg; Dupont, L.; Delarge, J.

in Journal de Pharmacie de Belgique (1992), 47

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