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See detailRealization of electroplating molds with thick positive SPR 220-7 photoresist
Kukharenka, Elena; Kraft, Michael ULiege

in Journal of Materials Science: Materials in Electronics (2003), 14(5-7), 319--322

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See detailFraming the future of antifungals in atopic dermatitis.
Nikkels, Arjen ULiege; Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 398-400

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease. Some fungal colonization or infection of the skin may exacerbate AD severity, particularly the so-called head and neck variant. In ... [more ▼]

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease. Some fungal colonization or infection of the skin may exacerbate AD severity, particularly the so-called head and neck variant. In addition, excessive intestinal colonization by Candida albicans may represent an additional triggering factor. Hence, there is a rationale to use antifungals in selected AD patients. Early trials with topical ketoconazole in head and neck AD showed a decrease in Malassezia colonization, but no significant improvement was observed in the clinical severity. In contrast, clinical improvement and decreased serum IgE were obtained in patients with positive Malassezia radioallergosorbent tests (RASTs) who were treated by oral ketoconazole. Some preliminary data suggested that oral itraconazole treatment in AD patients reduced the need for topical corticosteroids, provided clinical improvement particularly in head and neck AD, reduced the cutaneous and intestinal fungal colonization that may trigger AD, reduced the percentage of positive Malassezia cultures and demonstrated a decrease in C. albicans and Malassezia RAST values. Furthermore, beside its antifungal action, itraconazole in part relieves pruritus and inflammation. In conclusion, oral itraconazole treatment can alleviate AD severity in selected patients. Fluconazole is also effective. Further research is warranted to identify whether the load in skin surface fungal agents, the fungal RAST values and specific prick testing should be assessed in order to optimize the antifungal management in AD patients. [less ▲]

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See detailEfficacité du piégeage, par les méthodes classiques, des coléoptères saproxyliques en Région wallonne (Belgique)
Lhoir, Jonathan; Fagot, Jean ULiege; Thieren, Yves et al

in Notes Fauniques de Gembloux (2003), 50

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont ... [more ▼]

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont (Daverdisse village). Both forests are caracterized by a large amount of dead wood standing and laying down. The trapping's results are presented, with regards on the different technics used, on the differences between sites, on the beetles families and their saproxylic behavior. [less ▲]

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See detailField-dependent vortex pinning strength in a periodic array of antidots
Silhanek, Alejandro ULiege; Raedts, S.; Lange et al

in Physical Review. B : Condensed Matter (2003), 67(6),

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime ... [more ▼]

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime, vortex motion is of intravalley type and the penetration depth is related to the curvature of the pinning potential well alpha. For dc fields below the first matching field H-1, alpha reaches its highest value associated with a Mott insulator like phase where vortex lines are strongly localized at the pinning sites. For H-1<H-dc<H-2, the response is mainly due to the interstitial vortices and α drops to smaller values as expected for this metallic like regime. Strikingly, for H-2<H-dc<H-3, we observe that α reduces further down. However, for H-3<H-dc<H-4, a reentrance in the pinning strength is observed, due to a specific configuration of the flux-line lattice which strongly restricts the mobility of vortices. We present a possible explanation for the measured α(H-dc) dependence based on the different flux-line lattice configurations. [less ▲]

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See detailInteraction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Twizere, Jean-Claude ULiege; Kruys, Veronique; Lefebvre, Laurent et al

in Journal of the National Cancer Institute (2003), 95(24), 1846-59

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell ... [more ▼]

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell leukemia viruses and bovine leukemia virus). To better understand the molecular pathways leading to cell transformation, we aimed to identify cellular proteins interacting with Tax. METHODS: We used a yeast two-hybrid system to identify interacting cellular proteins. Interactions between Tax and candidate interacting cellular proteins were confirmed by glutathione S-transferase (GST) pulldown assays, co-immunoprecipitation, and confocal microscopy. Functional interactions between Tax and one interacting protein, tristetraprolin (TTP), were assessed by analyzing the expression of tumor necrosis factor-alpha (TNF-alpha), which is regulated by TTP, in mammalian cells (HeLa, D17, HEK 293, and RAW 264.7) transiently transfected with combinations of intact and mutant Tax and TTP. RESULTS: We obtained seven interacting cellular proteins, of which one, TTP, was further characterized. Tax and TTP were found to interact specifically through their respective carboxyl-terminal domains. The proteins colocalized in the cytoplasm in a region surrounding the nucleus of HeLa cells. Furthermore, coexpression of Tax was associated with nuclear accumulation of TTP. TTP is an immediate-early protein that inhibits expression of TNF-alpha at the post-transcriptional level. Expression of Tax reverted this inhibition, both in transient transfection experiments and in stably transfected macrophage cell lines. CONCLUSION: Tax, through its interactions with the TTP repressor, indirectly increases TNF-alpha expression. This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis. [less ▲]

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See detailLa varicelle et le zona ou les mystères de la latence d'un virus et de sa réactivation
Rentier, Bernard ULiege

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2003), 158(3-4), 169-73174-5

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features: chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological ... [more ▼]

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features: chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological features of these diseases such as complications of chicken pox, viral latency in sensory ganglia and reactivation as shingles with concurrent and possibly subsequent prolonged pain, are the sequels of the invasion of the peripheral nervous system during primary infection. Prevention is achieved by vaccination with a live attenuated virus strain and therapy calls for specific antiviral agents. In many respects, vzv behaves differently from close relatives. In particular, viral latency in the nervous system is basically different from that of other Herpesviridae. The recent discovery of the expression of some viral regulatory proteins during latency, although it had always been considered that vzv latency was silent, and demonstration that these proteins are immunogenic open new avenues concerning the immune control of vzv reactivation. [less ▲]

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See detailDe overmoed van de toevallige standaard
Meesters, Gert ULiege

in Over Taal (2003), 42(5), 106-107

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See detailUse of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury
Wirth, D.; Christians, E.; Li, Xiang ULiege et al

in Toxicology and Applied Pharmacology (2003), 192(1), 12-20

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection ... [more ▼]

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological changes occurring after Cd intranasal instillation (1 to 100 microg/mouse) was examined. HSF1-deficient mice were used to evaluate the role of this factor in lung protection. Cd instillation caused dose- and time-dependent changes in the respiratory pattern measured by plethysmography (Penh), and significant increases in lactate dehydrogenase (LDH) activity as well as macrophage and neutrophil counts in bronchoalveolar lavage fluids. HS preconditioning induced Hsp overexpression and reduced the Penh (-30%), LDH (-25%), and neutrophil (-55%) responses to subsequent administration of the highest Cd doses (50 and 100 microg) in wild-type mice. HSF1 deficiency abolished the HS response and its protective effect. In the absence of preconditioning, Hsf1(-/-) mice exhibited higher values of Penh (+70%) and LDH activity (+42%) compared with wild-type animals when exposed to the lowest Cd doses. Higher macrophage (+80%) and neutrophil counts (+115%) were recorded whatever the dose. Western blot analyses indicated that lung protection might be related to the kinetics of HSF1-dependent Hsp70 expression. Altogether, our data demonstrate that HS response elicited both by prior HS and by Cd itself moderates pulmonary injuries due to Cd instillation, and that HSF1 is a major mediator in this protection. [less ▲]

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See detailEvaluation of false transrectal ultrasonographic pregnancy diagnoses in sheep by measuring the plasma level of pregnancy-associated glycoproteins
Karen, A.; Beckers, Jean-François ULiege; Sulon, Joseph ULiege et al

in Reproduction Nutrition Development (2003), 43(6, NOV-DEC), 577-586

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy ... [more ▼]

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy-associated glycoproteins (ovPAG). A total of 424 Awassi x Merino ewes were synchronized for estrus and examined by transrectal ultrasonography. In Experiment 1, the ewes (n = 156) were repeatedly scanned in a standing position on d 29, 36 and 50 of gestation. Similarly, the ewes (n = 268) in Experiment 2 were scanned on d 24, 29 and 34 of gestation, but these ewes were fasted for 12 h prior to the examination and the abdominal wall of each animal was lifted up by the hands of the assistant during the scanning. Blood samples were withdrawn after each transrectal ultrasonographic examination in both experiments. Ovine PAG concentrations were measured in plasma by a heterologous radioimmunoassay and the cut-off value for pregnancy was greater than or equal to 1 ng.mL(-1). Based on the lambing performance, in Experiment 1, altogether 47 false negative and 38 false positive diagnoses were made by transrectal ultrasonography in 24 and 33 ewes, respectively between d 29 and 50 of gestation. In Experiment 2, altogether 8 false negative and 13 false positive diagnoses both were made in 7 ewes between d 24 and 34 of gestation. In both experiments, all ewes with false negative diagnoses had ovPAG concentrations higher than the threshold level for pregnancy diagnosis and all ewes with false positive diagnoses had ovPAG concentrations lower than the threshold of pregnancy. Furthermore, by the PAG-RIA test all lambed or aborted ewes (n = 63) were correctly diagnosed as pregnant and with three exceptions, all non-lambed ewes (n = 361) were correctly diagnosed as non-pregnant during the examined periods of both experiments. [less ▲]

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See detailMaking sense of the industrial revolution, English economy and society 1700-1850.
Geerkens, Eric ULiege

in Revue Belge de Philologie et d'Histoire (2003), 81(2), 519-521

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See detailLa majoration des quotités insaisissables pour enfant à charge
Georges, Frédéric ULiege

in Actualités du Droit (2003)

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See detailTwo-dimensional harmonic balance finite element modelling of electrical machines taking motion into account
Gyselinck, Johan; Dular, Patrick ULiege; Vandevelde, Lieven et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2003), 22(4), 1021-1036

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system ... [more ▼]

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system of algebraic equations is derived by applying the Galerkin approach to both the space and time discretisation. The harmonic basis functions, i.e. a cosine and a sine function for each nonzero frequency and a constant function 1 for the DC component, are used for approximating the periodic time variation as well as for weighing the time domain equations in the fundamental period. In practice, this requires some elementary manipulations of the moving band stiffness matrix. Magnetic saturation and electrical circuit coupling are considered in the analysis as well. As an application example, the noload operation of a permanent-magnet machine is considered. The voltage and induction waveforms obtained with the proposed harmonic balance method are shown to converge well to those obtained with time stepping. [less ▲]

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See detailRosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo.
Pelat, Michel; Dessy, Chantal; MASSION, Paul ULiege et al

in Circulation (2003), 107(19), 2480-6

BACKGROUND: Decreased heart rate variability (HRV) and increased blood pressure variability (BPV), determined in part by nitric oxide (NO)-dependent endothelial dysfunction, are correlated with adverse ... [more ▼]

BACKGROUND: Decreased heart rate variability (HRV) and increased blood pressure variability (BPV), determined in part by nitric oxide (NO)-dependent endothelial dysfunction, are correlated with adverse prognosis in cardiovascular diseases. We examined potential alterations in BPV and HRV in genetically dyslipidemic, apolipoprotein (apo) E-/-, and control mice and the effect of chronic statin treatment on these parameters in relation to their NO synthase (NOS)-modifying properties. METHODS AND RESULTS: BP and HR were recorded in unrestrained, nonanesthetized mice with implanted telemetry devices with or without rosuvastatin. Cardiac and aortic expression of endothelial NOS and caveolin-1 were measured by immunoblotting. Both systolic BP and HR were elevated in apoE-/- mice, with abolition of their circadian cycles. Spectral analysis showed an increase in their systolic BPV in the very-low-frequency (+17%) band and a decrease in HRV in the high-frequency (-57%) band, reflecting neurohumoral and autonomic dysfunction. Decreased sensitivity to acute injection of atropine or an NOS inhibitor indicated basal alterations in both parasympathetic and NOS regulatory systems in apoE-/- mice. Aortic caveolin-1 protein, an inhibitor of endothelial NOS, was also increased in these mice by 2.0-fold and correlated positively with systolic BPV in the very-low-frequency band. Rosuvastatin treatment corrected the hemodynamic and caveolin-1 expression changes despite persisting elevated plasma cholesterol levels. CONCLUSIONS: Rosuvastatin decreases caveolin-1 expression and promotes NOS function in apoE-/-, dyslipidemic mice in vivo, with concurrent improvements in BPV and HRV. This highlights the beneficial effects of rosuvastatin on cardiovascular function beyond those attributed to lipid lowering. [less ▲]

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See detailMoins-values et plus-values d'urbanisme: La révision de l'article 70 du CWATUP
Pâques, Michel ULiege

in Revue du Notariat Belge (2003)

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See detailProgramme de cartographie hydrogéologique de la Région wallonne.
Dossin, F.; Bouezmarni, Mohamed ULiege; Habils, F. et al

in Eco Karst (2003), (57), 7-10

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See detailLes compétences des jeunes de 15 ans en Communauté française en lecture, en mathématiques et en sciences : résultats de l'enquête PISA 2000
Lafontaine, Dominique ULiege; Baye, Ariane ULiege; Burton, Réginald et al

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 13-14

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See detailHierarchically mesoporous/macroporous metal oxides templated from polyethylene oxide surfactant assemblies
Blin, J.-L.; Léonard, Alexandre ULiege; Yuan, Z.-Y. et al

in Angewandte Chemie International Edition (2003), 42(25), 2872-2875

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like ... [more ▼]

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like shape (tapered towards the center) and are arranged parallel to each other and perpendicular to the tangent of the particle surface (see micrographs). The mesochannels are interconnected with funnel-like macrochannels. [less ▲]

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See detailNitric oxide synthase inhibition lowers activity of neurons with meningeal input in the rat spinal trigeminal nucleus
De Col, R.; Koulchitsky, Stanislav ULiege; Messlinger, K. B.

in Neuroreport (2003), 14(2), 229-32

Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn and the spinal trigeminal nucleus, where nociceptive information from extra- and intracranial tissues ... [more ▼]

Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn and the spinal trigeminal nucleus, where nociceptive information from extra- and intracranial tissues is processed. Extracellular impulse activity was recorded from neurons in the rat spinal trigeminal nucleus with afferent input from the cranial dura mater. In contrast to the inactive isomer D-NAME, infusion of the nitric oxide synthase inhibitor L-NAME (20 mg/kg) significantly reduced neuronal activity and increased systemic blood pressure. It is concluded that nitric oxide production contributes to the ongoing activity of sensitized neurons in the spinal trigeminal nucleus. The results suggest that nitric oxide may be involved in the generation and maintenance of primary headaches such as migraine. [less ▲]

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See detailCalculation of the scattering coefficient of a sine-shaped surface by solving the Helmholtz integral
Embrechts, Jean-Jacques ULiege; De Geetere, L.; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 67-74

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See detailL'importance économique du bénévolat associatif en Belgique
Mertens de Wilmars, Sybille ULiege

in Non Marchand : Management, Droit et Finance (2003), (11), 9-22

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See detailCalculation of the scattering coefficient of a sine-shaped surface by using the BEM method
De Geetere, L.; Embrechts, Jean-Jacques ULiege; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 75-83

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See detail'Aangewaaid uit een vreemd land': de westerse poëzie van G.J. Resink
Steyaert, Kris ULiege

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2003), 119(4), 279-299

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have ... [more ▼]

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have very much focused on what they perceive to be 'eastern' elements in Resink's oeuvre. I maintain that this has resulted in a one-sided interpretation, neglecting the underlying western, and in particular Dutch, tradition in many of Resink's poems. This article demonstrates the different ways in which Resink drew on the principles and literary output of the Eighties Movement, and how his formal experiments gain in significance when set against the work of poets like Perk, Kloos, and Dèr Mouw. The general view on Resink's later work as being inferior to his earlier poetry is shown to be the result of unwarranted preconceptions. [less ▲]

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See detailMarine mammals from Northeast Atlantic: relationship between their trophic status as determined by delta C-13 and delta N-15 measurements and their trace metal concentrations
Das, Krishna ULiege; Beans, Cristina; Holsbeek, Ludo et al

in Marine Environmental Research (2003), 56(3),

The relationship between trophic position through delta(13)C and delta(15)N and trace metal concentrations (Zn, Cd, Cu and Hg) was investigated in the tissues of six marine mammal species from the ... [more ▼]

The relationship between trophic position through delta(13)C and delta(15)N and trace metal concentrations (Zn, Cd, Cu and Hg) was investigated in the tissues of six marine mammal species from the Northeast Atlantic: striped dolphin Stenella coeruleoalba, common dolphin, Delphinus delphis. Atlantic white-sided dolphin Lagenorhynchus acutus, harbour porpoise Phocoena phocoena, white beaked-dolphin Lagenorhynchus albirostris, grey seal Halichoerus grypus stranded on French Channel and Irish coasts. White-beaked dolphins, harbour porpoises, white-sided dolphins, common and striped dolphins display the same relative and decreasing trophic position, as measured by delta(15)N values, along both the Irish and French channel coasts, reflecting conservative trophic habits between these two places. Hepatic and renal Cd concentrations were significantly correlated to muscle delta(13)C and delta(15)N values while Hg, Zn and Cu did not. These results suggest that Cd accumulation is partly linked to the diet while other factors Such as age or body condition might explain Hg, Zn or Cu variability in marine mammals. Combined stable isotope and trace metal analyses appear to be useful tools for the study of marine mammal ecology. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailSolar-blind diamond detectors for LYRA, the solar VUV radiometer on board PROBA II
Benmoussa, A.; Hochedez, J. F.; Schmutz, W. K. et al

in Experimental Astronomy (2003), 16(3), 141-148

Fabrication, packaging and experimental results on the calibration of metal-semiconductor-metal (MSM) photodetectors made on diamond are reported. LYRA (Lyrnan-alpha RAdiometer onboard PROBA-2) will use ... [more ▼]

Fabrication, packaging and experimental results on the calibration of metal-semiconductor-metal (MSM) photodetectors made on diamond are reported. LYRA (Lyrnan-alpha RAdiometer onboard PROBA-2) will use diamond detectors for the first time in space for a solar physics instrument. A set of measurement campaigns was designed to obtain the XUV-to-VIS responsivity of the devices and other characterizations. The measurements of responsivity in EUV and VUV spectral ranges (40-240 nm) have been carried out by the Physkalisch-Technische Bundesanstalt (PTB) in Germany at the electron storage ring BESSY II. The longer wavelength range from 210 to 1127 nm was measured with monochromatic light by using a Xe-lamp at IMO-IMOMEC. The diamond detectors exhibit a photoresponse which lie in the 35-65 mA/W range at 200 nm (corresponding to an external quantum efficiency of 20-40%) and indicate a visible rejection ratio (200-500 nm) higher than four orders of magnitude. [less ▲]

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See detailLes marques de provenance des incunables conservés à la Bibliothèque royale de Belgique : essai de synthèse
Adam, Renaud ULiege

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in Belgie (2003), 75

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See detailNecrotizing varicella zoster virus folliculitis.
Nikkels, Arjen ULiege; Pierard, Gérald ULiege

in European Journal of Dermatology (2003), 13(6), 587-9

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented ... [more ▼]

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented with a single large infiltrated plaque on the abdomen. Although histology showed a necrotizing folliculitis surrounded by a dense perifollicular inflammatory infiltrate, the clinical presentation was not suggestive of folliculitis. Subtle cyto-histological clues for viral infection were suggested. Immunohistochemistry revealed the presence of VZV in the remnants of the follicular structures. This report underlines one of the protean clinical presentations of VZV skin infections and highlights the discreteness of typical VZV-related cyto-histological alterations. Complementary VZV identification methods such as immunohistochemistry, are helpful in order to increase the diagnostic accuracy of unusual VZV lesions. [less ▲]

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See detailMarocains de Belgique : du travailleur immigré au citoyen transnational
Bousetta, Hassan ULiege; Martiniello, Marco ULiege

in Hommes & Migrations (2003), 1242(Mars-Avril), 94-106

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See detailTemporal variability of neurography
WANG, François-Charles ULiege; Horward, Alain

in Journal of Neurology (2003)

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See detailHC gp-39 gene is upregulated in glioblastomas.
Shostak, Kateryna ULiege; Labunskyy, Vyacheslav; Dmitrenko, Vladimir et al

in Cancer Letters (2003), 198(2), 203-10

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression ... [more ▼]

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression (SAGE). Analysis revealed HC gp-39 among the genes with the most pronounced changes of expression in tumor cells. Northern hybridization confirmed the results of computer analysis and showed that enhanced expression of the HC gp-39 gene was mainly in GBMs and occasionally in anaplastic astrocytomas. Neither SAGE nor Northern analysis revealed the presence of HC gp-39 mRNA in the glioblastoma cell line, thus the detection of increased quantities of this mRNA in GBMs may be associated with activated macrophages. Since the numbers of infiltrating macrophages and small vessel density are higher in glioblastomas than in anaplastic astrocytomas or astrocytomas, the HC gp-39 gene can be used as a molecular marker in the analysis of malignant progression of astrocytic gliomas. [less ▲]

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See detailL'image du mois. Un chancre mou.
Nikkels, Arjen ULiege; Arrese Estrada, Jorge ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2003), 58(2), 64-6

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See detailMismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects.
Hansenne, Michel ULiege; Pinto, Emmanuel ULiege; Scantamburlo, Gabrielle ULiege et al

in Human Psychopharmacology (2003), 18(3), 201-5

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immediate vicinity of the primary auditory cortex and with possible contribution from the frontal cortex. However, few data are available concerning the influence of neurotransmitter systems on the MMN. In this study, the relationship between both noradrenergic and dopaminergic systems and the MMN were investigated in 34 healthy volunteers. Noradrenergic and dopaminergic activities were assessed with the apomorphine and clonidine challenge tests. The results showed no significant relationship between either growth hormone (GH) responses to apomorphine or clonidine and the MMN amplitude or latency. Therefore, this study does not demonstrate the implication of dopaminergic and noradrenergic activities as assessed by GH response to apomorphine and clonidine for the generation and/or the modulation of the MMN. However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN. [less ▲]

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See detailDetuning effects on the mazer
Martin, John ULiege; Bastin, Thierry ULiege

in Physicalia Magazine (2003), 25

A short review of the theoretical studies of the cold atom micromaser (mazer) is presented. Existing models are then improved by considering more general working conditions. Especially, the mazer physics ... [more ▼]

A short review of the theoretical studies of the cold atom micromaser (mazer) is presented. Existing models are then improved by considering more general working conditions. Especially, the mazer physics is investigated in the situation where a detuning between the cavity mode and the atomic transition frequency is present. Interesting new effects are pointed out. Especially, it is shown that the cavity may slow down or speed up the atoms according to the sign of the detuning and that the induced emission process may be completely blocked by use of a positive detuning. The transmission probability of ultracold atoms through a micromaser is also studied and we generalize previous results established in the resonant case. In particular, it is shown that the velocity selection of cold atoms passing through the micromaser can be very easily tuned and enhanced using a nonresonant field inside the cavity. [less ▲]

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See detailHaplotype diversity of the myostatin gene among beef cattle breeds
Dunner, S.; Miranda, M. E.; Amigues, Y. et al

in Genetics, Selection, Evolution (2003), 35(1, JAN-FEB), 103-118

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were ... [more ▼]

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were identified which contribute to the high polymorphism (1 SNP every 100 bp) present in this small gene; twenty haplotypes were described and a genotyping method was set up using the Oligonucleotide Ligation Assay (OLA) method. Some haplotypes appeared to be exclusive to a particular breed; this was the case for 5 in the Charolaise (involving mutation Q204X) and 7 in the Maine-Anjou (involving mutation E226X). The relationships between the different haplotypes were studied, thus allowing to test the earlier hypothesis on the origin of muscular hypertrophy in Europe: muscular hypertrophy (namely m821 (del11)) was mainly spread in different waves from northern Europe milk purpose populations in most breeds; however, other mutations (mostly disruptive) arose in a single breed, were highly selected and have since scarcely evolved to other populations. [less ▲]

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See detailLe système d'échange de quotas d'émissions de gaz à effet de serre dans la Communauté européenne
Pâques, Michel ULiege

in Aménagement - Environnement (2003)

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See detailIntérêt du monitoring continu du glucose interstitiel chez le patient diabétique de type 1
RADERMECKER, Régis ULiege; Sélam, Jean-Louis; SCHEEN, André ULiege

in Revue Médicale Suisse (2003), 61

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See detailComments on Pouillot, R., Gerbier, G. & Gadner, I.A. “TAGS”, a program for the evaluation of test accuracy in the absence of a gold standard
Berkvens, D. L.; Speybroeck, N.; Lesaffre, E. et al

in Preventive Veterinary Medicine (2003), 59

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See detailElectronic interface design for an electrically floating micro-disc
Gindila, Mircea V.; Kraft, Michael ULiege

in Journal of Micromechanics and Microengineering (2003), 13(4), 11-16

The design of an electronic interface for an electrically floating micro-disc is presented. The system, based on a second order electromechanical – modulator, can be used as a multi-axis capacitive ... [more ▼]

The design of an electronic interface for an electrically floating micro-disc is presented. The system, based on a second order electromechanical – modulator, can be used as a multi-axis capacitive accelerometer with the proof mass levitated by electrostatic forces. A synchronous detection scheme, used to sense the position of the proof mass, has been designed, simulated in PSpice TM and successfully implemented on a PCB. The interface contains a differential pick-off with no ohmic connection to the proof mass, which distinguishes the circuit from typical sensing circuits for MEMS capacitive accelerometers. A noise analysis of the pick-off circuit was performed, and an electronic equivalent model of the sensing circuit has been developed and used to analyse the linearity of its transfer function. The linearity of the sensing circuit was confirmed experimentally using the PCB implementation. [less ▲]

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See detail"Sum Petri Aegidii" : kanttekeningen bij een recent opgedoken boek uit de bibliotheek van Pieter Gillis (1486-1533)
Adam, Renaud ULiege

in De Gulden Passer = Le compas d'or (2003), 81

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See detailLe médecin, la trousse et le livre dans le monde gréco-romain
Marganne, Marie-Hélène ULiege

in Papyrologica Lupiensia (2003), 12

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See detailThree years of free-air CO2 enrichment (POPFACE) only slightly affects profiles of light and leaf characteristics in closed canopies of Populus.
Gielen, B; Liberloo, M; Bogaert, Jan ULiege et al

in Global Change Biology (2003), 9(7), 1022-1037

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See detailUn syndrome de Netherton atypique
EL HAYDERI, Lara ULiege; DEZFOULIAN, Bita ULiege; NIKKELS, Arjen ULiege

in Skin (2003), 16(5), 38

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See detailL’implication dans la recherche clinique : un chemin vers la psychanalyse
Naziri, Despina ULiege

in Revue Belge de Psychanalyse (2003), 40(printemps), 3-24

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon ... [more ▼]

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon travail sur le recours répétitif à l’avortement en explicitant mon cheminement, tant au niveau de la pensée que de l’expérience, et en reprenant quelques repères de mon itinéraire personnel. [less ▲]

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See detailLes ateliers du Matériel: pivots de la diffusion de l'organisation rationnelle au sein de la Société Nationale des Chemins de fer Belges, 1910-1940
Geerkens, Eric ULiege

in Revue d'Histoire des Chemins de Fer (2003), (28-29), 207-221

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d ... [more ▼]

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d'expérimentation, le point de diffusion de ces méthodes vers d'autres services de la société, mais aussi vers les constructeurs belges de matériel roulant. L'introduction du système de rémunération Rowan à l'atelier central de Malines (principal atelier du matériel du réseau belge) peut être tenu pour le point de départ de l'adoption de méthodes d'organisation rationnelle, dans la mesure où elle impliquait une première forme d'étude systématique du travail ouvrier. Au lendemain de la Première Guerre, une nouvelle organisation du travail d'inspiration taylorienne et son corollaire indispensable - une comptabilité industrielle - vont être introduits dans les ateliers de moyenne réparation des locomotives. Associée initialement à une concentration des ateliers, la taylorisation ne va cesser de progresser. L'adoption du travail à la chaîne pour le placement de freins à air sur ses wagons a constitué une des innovations majeures dans l'organisation du travail à la SNCB. Forte de cette expérience, la SNCB va étendre le travail à la chaîne à d'autres travaux exécutés par le service du Matériel, puis à certaines activités d'autres services. Ainsi cette technique, adoptée pour une opération ponctuelle, va être appliquée aux travaux récurrents de réparation et d'entretien du matériel roulant. Au service de l'Exploitation, la recherche d'un équilibre optimal entre les tâches successives, déterminant majeur du rendement dans le travail à la chaîne, va fournir le principe d'une organisation nouvelle du triage des wagons; de même, les travaux d'entretien des voies vont être réorganisés de manière à les faire exécuter suivant certains principes du travail à la chaîne. La baisse du trafic de marchandises et la dégradation de ses résultats financiers au début des années '30 vont amener la SNCB à approfondir la rationalisation des différents travaux, par une combinaison de techniques déjà éprouvées et de procédures nouvelles; la gestion très centralisée des ateliers va s'appuyer sur deux techniques particulières: les plannings et le contrôle budgétaire. Par une modification de ses principes d'adjudication, la société va aussi imposer le travail à la chaîne, puis le planning, à ses fournisseurs de matériel roulant, amenant ainsi une modernisation de leurs méthodes de travail. L'adoption et la diffusion des méthodes d'organisation a impliqué une très forte centralisation des structures administratives, dont une illustration est donnée par le service d'entretien des wagons, où tous les ateliers sont dirigés par le service central des wagons de la direction du Matériel. Au début de la Seconde Guerre, les limites de cette centralisation vont être perçues par les fonctionnaires dirigeants qui avaient introduit les méthodes d'organisation tayloriennes. Il en résultera une décentralisation des responsabilités; son abandon au lendemain du conflit marque toutefois le retour à une centralisation taylorienne dont les effets se feront sentir pendant plusieurs décennies. [less ▲]

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See detailMeasure Noun constructions : an instance of semantically-driven grammaticalization
Brems, Lieselotte ULiege

in International Journal of Corpus Linguistics (2003), 8(2), 283-312

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See detailEffet des bordures de champs sur les populations de Chrysopes [Neuroptera: Chrysopidae] en cultures maraîchères
Mignon, Jacques ULiege; Colignon, Pierre; Haubruge, Eric ULiege et al

in Phytoprotection (2003), 84(2), 121-128

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and ... [more ▼]

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and Coccinellidae is well known but very few studies have been realised to assess its effect on the abundance and diversity of Chrysopidae. In 2000 and 2001, the impact of adjacent habitats on lacewing populations was investigated in both carrot and broad bean open fields. Three types of field borders were selected: (1) set-asides mainly composed by Lolium perenne and Trifolium spp., (2) crops (wheat, beet or other vegetables) and (3) woody areas (mixture of Acer sp., Populus sp. and Salix sp.). Insects were caught using yellow pan traps. Chrysopidae populations were shown to be significantly lower in carrot and broad bean fields bordered with woodland. Lacewing and other Neuroptera species richness were always low and were discussed in relation with their role of pest predators associated with other aphidophagous insects. [less ▲]

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See detailLes apports du projet Johns Hopkins dans la statistique du non-marchand
Mertens de Wilmars, Sybille ULiege

in Non Marchand : Management, Droit et Finance (2003), (11), 29-38

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See detailLarval development of Myzostoma cirriferum (Myzostomida)
Eeckhaut, I.; Fievez, Laurence ULiege; Muller, M. C.

in Journal of Morphology (2003), 258

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and ... [more ▼]

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and the metatrochophore. The protrochophore is a ball-shaped larva present in culture from 18-48 h after egg laying. It has no internal organs and its body is made of three cell types: covering cells and ciliated cells that are external and surrounded by a cuticle, and resting cells that fill the blastocoel. The trochophore is a pear-shaped larva that develops 20-72 h after egg laying; the body includes the same three cell types as the previous stage. The metatrochophore is a pear-shaped larva that develops between 40 h and 14 days and is characterized by the presence of two bundles of four chaetae. When fully developed, the metatrochophore has a digestive system (made of a pharynx, an esophagus, and a blind digestive pouch), two pairs of protonephridia, and a nervous system composed of a supraesophageal ganglion, circumesophageal connectives, and dorsal and ventral nerves. Metamorphosis generally occurs 7 days after egg laying. At that time, the metatrochophore loses its chaetae and becomes pleated ventrally. This ultrastructural analysis suggests that chaetae and the five ventral longitudinal nerve cords of M. cirriferum metatrochophores are homologous structures to those observed in some polychaete trochophores. Coupled with recent phylogenetic analyses, where the Myzostomida are placed outside the Annelida, homologies between myzostomid and polychaete larvae support the view that a trochophore appeared early during the spiralian evolution [less ▲]

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See detailNasal aspergillosis associated with an impacted canine tooth in a Belgian shepherd dog
Saunders, J.; Clercx, Cécile ULiege; Zonderland, J.L. et al

in Vlaams Diergeneeskundig Tijdschrift (2003), 72(6), 396-398

A 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left ... [more ▼]

A 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left nasal cavity with caudal displacement of the tooth root. Rhinoscopy demonstrated the presence of fungal colonies. The impacted tooth was surgically removed and the nasal cavity flushed with enilconazole 1%. No recurrence was observed during a follow-up period of two years. [less ▲]

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See detailDe Cheddar- en Creswell-spitsen van Zeijen (Dr.): ‘projectielen’ of ‘messen’?
Rots, Veerle ULiege; Stapert, Dick; Johanssen, Lykke

in Paleo-Aktueel (2003), 13

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See detailAcetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
Ambrosini, A.; Pierelli, F.; Schoenen, Jean ULiege

in Cephalalgia : An International Journal of Headache (2003), 23(2), 75-8

Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2 ... [more ▼]

Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2+-channels on motor axons controlling stimulation-induced acetylcholine release. Acetazolamide, which is thought to ameliorate ion channel function, was shown effective in familial hemiplegic migraine and episodic ataxia type 2, both of which are associated with mutations of the neuronal Ca2+-channel gene CACNA1A, as well as in aura status. We treated therefore in an open pilot study five non-hemiplegic migraineurs showing mild SFEMG abnormalities with acetazolamide for several weeks. This was followed by a normalization of SFEMG recordings in all patients and by clinical improvement in four. These results support the assumption that the subclinical impairment of neuromuscular transmission found in certain migraineurs might be due to dysfunctioning Ca2+-channels. [less ▲]

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See detailApport à la connaisance du genre Rhizophagus Herbst, 1793 (Coleoptera: Clavicornia Monotomidae) en région wallonne (Belgique)
Thieren, Yves; Fagot, Jean ULiege; Lhoir, Jonathan et al

in Notes Fauniques de Gembloux (2003), 50

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations ... [more ▼]

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations between species and trapping methods and on the species activity during the six months trapping. Waiting for an exhaustive revision of the genera, a primary point is made on the Rhizophagus in Belgium and a prime list is given with a lot of ethological considerations. [less ▲]

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See detailCalorimetry of cationic liposome-DNA complex and intracellular visualization of the complexes.
Elouahabi, Abdelatif; Thiry, Marc ULiege; Pector, Veronique et al

in Methods in Enzymology (2003), 373

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See detailDownregulation of putative tumor suppressor gene TSC-22 in human brain tumors.
Shostak, Kateryna ULiege; Dmitrenko, Vladimir V.; Garifulin, Oleg M. et al

in Journal of Surgical Oncology (2003), 82(1), 57-64

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and ... [more ▼]

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and human postnatal brain cDNA libraries was performed by differential hybridization with glioblastoma multiforme and human normal brain cDNAs. RESULTS: Repeated differential hybridization of more than 100 cDNA clones selected by primary screening and analysis of RNA from adult normal brain and glial tumors showed 16 nucleotide sequences differentially expressed between normal brain and brain tumors. Among others, decreased content in astrocytic tumors was determined for TSC-22 mRNA corresponding to cDNA in the ICRFp507J1041 clone from human fetal brain cDNA library. Northern blot hybridization of RNA from different human brain tumors showed very low amounts of TSC-22 mRNA in most investigated samples of GBM, anaplastic astrocytoma, and some other tumors. Complete lack of expression of TSC-22 occurred in one sample of anaplastic astrocytoma, as well as in meningioma, brain sarcoma, sarcomatous meningioma, and oligodendroglioma. The differential expression of TSC-22 gene was confirmed by semiquantitative RT-PCR in 15 samples of astrocytomas WHO grade II-IV and three samples of normal brain. CONCLUSIONS: Significantly decreased levels of TSC-22 mRNA in human brain and salivary gland tumors and antiproliferative role of TSC-22 strongly suggest a tumor suppressor role for TSC-22. J. [less ▲]

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See detailFattening of Belgian Blue double-muscled culled females: animal performance, carcass characteristics and meat quality
Cabaraux, Jean-François ULiege; Hornick, Jean-Luc ULiege; Dufrasne, Isabelle ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 423-431

In order to measure Animal performance and, carcass and meat characteristics of Belgian Blue double-muscled culled females, a fattening trial was carried out on a total of 78 animals. Fifteen females were ... [more ▼]

In order to measure Animal performance and, carcass and meat characteristics of Belgian Blue double-muscled culled females, a fattening trial was carried out on a total of 78 animals. Fifteen females were slaughtered at the beginning of the trial and 63 were fattened on a maize silage based diet. The initial average live weight was 571.2kg. The total fattening gain was 91.1 kg for a period of 91.4 days. At slaughter, the warm carcass weight was 405.9kg and the killing-out proportion 63.3%. The carcasses were characterised by a high proportion of muscles (67.6%) and rather low proportions of adipose tissue (18.2%) and bones (14.2%). The muscle and adipose tissue accretions were 36.0 and 28.2 kg. Meat was lean as indicated by high protein content (88.5%) and low fat content (6.6%) in dry matter. A high proportion of polyunsaturated fatty acids was also found (6.8 mol %). [less ▲]

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See detailSolution structural study of BlaI: implications for the repression of genes involved in beta-lactam antibiotic resistance.
Melckebeke, Helene Van; Vreuls, Christelle ULiege; Gans, Pierre et al

in Journal of Molecular Biology (2003), 333(4), 711-20

beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam antibiotics, which are otherwise highly clinically effective. Two repressors (BlaI and MecI) regulate ... [more ▼]

beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam antibiotics, which are otherwise highly clinically effective. Two repressors (BlaI and MecI) regulate expression of these inducible proteins. Here, we present the first solution structure of the 82 amino acid residue DNA-binding domain of Bacillus licheniformis BlaI which is very similar in primary sequence to the medically significant Staphyloccocal BlaI and MecI proteins. This structure is composed of a compact core of three alpha-helices and a three-stranded beta-sheet typical of the winged helix protein (WHP) family. The protein/DNA complex was studied by NMR chemical shift comparison between the free and complexed forms of BlaI. Residues involved in DNA interaction were identified and a WHP canonical model of interaction with the operators is proposed. In this model, specific contacts occur between the base-pairs of the TACA motif and conserved amino acid residues of the repressor helix H3. These results help toward understanding the repression and induction mechanism of the genes coding for beta-lactamase and PBP2'. [less ▲]

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See detailChorionic expression of heterogeneous products of the PAG (Pregnancy-Associated Glycoprotein) gene family secreted in vitro throughout embryonic and foetal development in the pig
Szafranska, B.; Panasiewicz, G.; Majewska, M. et al

in Reproduction Nutrition Development (2003), 43(6), 497-516

Porcine PAG (pPAG) are placental products of a multigene family that is strongly expressed in the chorionic epithelium (trophoblast and trophectoderm). The objective of this study was to define a pattern ... [more ▼]

Porcine PAG (pPAG) are placental products of a multigene family that is strongly expressed in the chorionic epithelium (trophoblast and trophectoderm). The objective of this study was to define a pattern of the pPAG proteins, secreted in vitro by chorionic explants harvested on 16-77 days of pregnancy. Trophoblastic and trophectodermal explants were collected from pregnant (PR) gilts (n = 27) and used for protein in vitro production (8-261 h). Endometrial explants of luteal-phase gilts (E10, n = 4) and pseudopregnant gilts (PsE, n = 2) were used as negative controls for protein immunoblotting. Proteins (PR, E10, PsE) were isolated mainly from incubation media, fractionated, dialysed and separated by SDS-PAGE. Heterogeneous Western blotting with various polyclonal anti-PAG sera raised against bovine or ovine antigens (anti-bPAG, or anti-oPAG) initially identified the pPAG proteins. Such blotting of fractionated chorionic proteins allowed for the isolation of porcine antigens that were employed as immunogens to raise several homologous antisera (anti-pPAG). Crude antisera were adsorbed on endometrial extracts or proteins of non-PR pigs, to remove non-relevant antibodies. The patterns of pPAG proteins secreted in Vitro varied throughout pregnancy (35-72 kDa). During implantation, similar to43 kDa (Day 16) or similar to68.1 kDa (Days 17-25) pPAG proteins were detected. During placentation and as pregnancy advanced (Days 31-77), similar to72.3 kDa pPAG proteins were observed. The secretions of parallel multiple smaller proteins (35.4-47.2 kDa), presumably, as forms of processed pPAG precursors, increased with the progress of gestation. In conclusion, the pPAG protein family plays a very important role during implantation, placenta formation and embryonic/foetal development in the pig. [less ▲]

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See detailCes nombres que l'on dit "imaginaires".
Rosseel, H.; Schneider, Marguerite ULiege

in Petit X (2003), 63

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See detailRadiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL : étude prospective de phase II
Zouhair, A; COUCKE, Philippe ULiege; Azria, D. et al

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (2003), 7

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods ... [more ▼]

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. – Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43–81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI) * Auteur correspondant. Adresse e-mail : abderrahim.zouhair@chuv.hospvd.ch (A. Zouhair). Cancer/Radiothérapie 7 (2003) 231–236 www.elsevier.com/locate/canrad © 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits réservés. doi:10.1016/S1278-3218(03)00041-6 was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam RT 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. – According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0–16). No grade 4 toxicity was observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, and actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion. – The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fractions per week) is feasible with local control rates comparable to that of published data. Acute RT-related morbidity is acceptable. [less ▲]

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See detailElectroplating moulds using dry film thick negative photoresist
Kukharenka, Elena; Farooqui, Mateen M.; Grigore, L. et al

in Journal of Micromechanics and Microengineering (2003), 13(4), 67-74

This paper reports on progress on the feasibility of fabricating moulds for electroplating using Ordyl P-50100 (negative) acrylate polymer based dry film photoresist, commercially available from Elga ... [more ▼]

This paper reports on progress on the feasibility of fabricating moulds for electroplating using Ordyl P-50100 (negative) acrylate polymer based dry film photoresist, commercially available from Elga Europe (http://www.elgaeurope.it). We used this photoresist as an alternative to SU8 negative epoxy based photoresist, which is very difficult to process and remove after electroplating (Lorenz et al 1998 Microelectron. Eng. 41/42 371–4, Eyre et al 1998 Proc. MEMS’98 (Heidelberg) (Piscataway, NJ: IEEE) pp 218–22). Ordyl P-50100 is easy to work with and can be easily removed after processing. A single layer of Ordyl P-50100 was deposited by lamination up to 20 µm thickness. Thicker layers (200 µm and more) can be achieved with multilayer lamination using a manual laminator. For our applications we found that Ordyl P-50100 dry film photoresist is a very good alternative to SU8 for the realization of 100 µm high moulds. The results presented will open up new possibilities for low-cost LIGA-type processes for MEMS applications. [less ▲]

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See detailPredictive factors in locally advanced rectal cancer treated with preoperative hyperfractionated and accelerated radiotherapy.
Bouzourene, H; Bosman, F; Matter, M et al

in Human Pathology (2003), 34(6), 541-548

This study examines the prognostic significance of pathologic factors in patients with primary locally advanced rectal cancer treated prospectively with preoperative radiotherapy. From 1992 to 1998, 104 ... [more ▼]

This study examines the prognostic significance of pathologic factors in patients with primary locally advanced rectal cancer treated prospectively with preoperative radiotherapy. From 1992 to 1998, 104 patients with rectal cancer of grades T3 or T4 and any N underwent preoperative radiotherapy followed by surgical resection. Survival curves were estimated according to the Kaplan-Meier method. Correlation of outcome with clinicopathologic variables (pathologic tumor and lymph node staging, histology, radial resection margin [RRM], clearance, vessel involvement, and tumor regression grade [TRG], quantitated in 5 grades) was evaluated using the Cox proportional hazards model. None of the patients achieved a histologically confirmed complete pathologic response, but 79% of the patients showed partial tumor regression (TRG2–4) and 21% did not show any tumor regression (TRG5). Among the tumors, 22% were of a mucinous type. The RRM was free of tumor in 76% of the surgical specimens. The median clearance was 2 mm. Vascular invasion was present in 37 cases (36%). In the univariate analysis, lymph node metastases, absence of tumor regression, positive RRM, and vascular invasion were correlated with adverse overall survival and diseasefree survival; absence of tumor regression, positive RRM, and clearance <2 mm were correlated with local recurrences; and advanced pT stage was correlated only with disease-free survival. However, in the multivariate analysis, only lymph node metastases and RRM were independent prognostic factors for overall survival and disease-free survival, and clearance <2 mm was an independent prognostic factor for local control. Pathologic parameters remain strong determinants of local recurrence and survival in locally advanced rectal cancer, treated preoperatively with hyperfractionated and accelerated radiotherapy. We show that patients with advanced pT, positive lymph nodes, vascular invasion, positive RRM, clearance <2 mm, or absence of tumor regression are known to have poor clinical outcome. HUM PATHOL 34:541-548. © 2003 Elsevier Inc. All rights reserved. Abbreviations: , computed tomography; DFS, disease-free survival; HART, hyperfractionated accelerated radiotherapy; OS, overall survival; RRM, radial resection margin; TRG, tumor regression grade. [less ▲]

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See detailApproximation algorithms for the design of SDH/SONET networks
Brauner, Nadia; Crama, Yves ULiege; Finke, Gerd et al

in RAIRO : Operations Research = Recherche Opérationnelle (2003), 37(4, OCT-DEC), 235-247

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this ... [more ▼]

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this problem efficiently in practice, fast greedy algorithms and a tabu-search method are proposed and analyzed by means of an experimental study. [less ▲]

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See detailImage analysis characterization of multi-walled carbon nanotubes
Gommes, Cédric ULiege; Blacher, Silvia ULiege; Masenelli-Varlot, Karine et al

in Carbon (2003), 41(13), 2561-2572

An original image analysis method is presented to characterize multi-walled carbon nanotubes from transmission electron microscopy images. The analysis is performed in three steps: (i) image preprocessing ... [more ▼]

An original image analysis method is presented to characterize multi-walled carbon nanotubes from transmission electron microscopy images. The analysis is performed in three steps: (i) image preprocessing in order to isolate the nanotubes from the background, (ii) image segmentation, aiming at keeping only the measurable sections of nanotubes, and finally (iii) tube characteristics measurement. The measurement is based on a Lambert-like electron absorption law and is performed on the original gray level image itself. Two geometrical and one physical characteristics are determined for each tube, namely, its outer and inner radius and a linear electron absorption coefficient. The method is illustrated by comparing a pristine and an annealed carbon nanotube samples. The compaction of the tube walls during annealing is shown to result from a lowering of the external radius while the inner radius is left unchanged. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailVegetation mapping: from patch to planet (R. Alexander, A.C. Millington).
Bogaert, Jan ULiege

in Landscape & Urban Planning (2003), 64

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See detailHarm avoidance is related to mismatch negativity (MMN) amplitude in healthy subjects
Hansenne, Michel ULiege; Pinto, Emmanuel ULiege; Scantamburlo, Gabrielle ULiege et al

in Personality & Individual Differences (2003), 34(6), 1039-1048

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on ... [more ▼]

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on the possible relationships between personality and automatic attention or early sensory processing. In the present study the relationships between the mismatch negativity (MMN) and personality described by the Cloninger model of personality were investigated. Subjects were 32 healthy volunteers. The MMN was recorded with frequent stimuli tones of 1470 Hz, 70 dB and 40 ms duration, and target (20%) tones of 1470 Hz, 70 dB, 80 ms duration. The subjects completed a French version of the 226-item self-questionnaire TCI within the day following psychophysiological recording. The results showed that the HA dimension was negatively correlated with the MMN amplitude. The association was more present among women than men. No significant relationship existed between the other dimensions of personality and either the MMN amplitude or latency. These findings suggest that the MMN is related to the behavioral inhibition system (BIS), a fact which is consistent with clinical studies conducted on schizophrenia and anxiety disorders. In conclusion, this study suggests that personality dimensions induce different automatic attitudes towards the processing of information. (C) 2002 Published by Elsevier Science Ltd. [less ▲]

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See detailUse of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses.
Van Erck, Emmanuelle ULiege; Votion, Dominique ULiege; Kirschvink, Nathalie et al

in American Journal of Veterinary Research (2003), 64(11), 1414-1420

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses ... [more ▼]

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses. ANIMALS: 10 horses (4 healthy; 6 with recurrent airway obstruction [heaves] in remission). PROCEDURE: Healthy horses (group-A horses) and heaves-affected horses (group-B horses) were housed in a controlled environment. At each step of a methacholine bronchoprovocation test, threshold concentration (TC(2SD); results in a 2-fold increase in SD of a value) and sensitivity index (SI) were determined for respiratory tract system resistance (R(rs)) and respiratory tract system reactance (X(rs)) at 5 to 20 Hz by use of IOS and for total pulmonary resistance (RL) and dynamic lung compliance (C(dyn)), by use of CRT. RESULTS: Bronchoconstriction resulted in an increase in R(rs) at 5 Hz (R(5Hz)) and a decrease in X(rs) at all frequencies. Most sensitive parameters were X(rs) at 5 Hz (X(5Hz)), R(5Hz), and R(5Hz):R(10Hz) ratio; RL and the provocation concentration of methacholine resulting in a 35% decrease in dynamic compliance (PC(35)C(dyn)) were significantly less sensitive than these IOS parameters. The TC(2SD) for X(rs) at 5 and 10 Hz was significantly lower in group-B horses, compared with group-A horses. The lowest TC(2SD) was obtained for X(5Hz) in group-B horses and R(5Hz) in group-A horses. CONCLUSIONS AND CLINICAL RELEVANCE: In contrast to CRT parameters, IOS parameters were significantly more sensitive for testing pulmonary function.The IOS provides a practical and noninvasive pulmonary function test that may be useful in assessing subclinical changes in horses. [less ▲]

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See detailAfrique : crise de l’Université nationale, développement et institutionnalisation des inégalités
Poncelet, Marc ULiege

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2003), 49 (2003-2)

The unbalanced growth, social instability and "lack of all" of african universities should not hide the deep dynamics of inequalities they project into the social construction of society

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See detailIncreased electron donor and electron acceptor characters enhance the adhesion between oil droplets and cells of Yarrowia lipolytica as evaluated by a new cytometric assay
Aguedo, Mario ULiege; Waché, Y.; Mazoyer, V. et al

in Journal of Agricultural and Food Chemistry (2003), 51(10), 3007-3011

The adhesion of methyl ricinoleate droplets to cells of the yeast Yarrowia lipolytica was investigated. A new cytometric method, relying on the double staining of fatty globules with Nile Red and of cells ... [more ▼]

The adhesion of methyl ricinoleate droplets to cells of the yeast Yarrowia lipolytica was investigated. A new cytometric method, relying on the double staining of fatty globules with Nile Red and of cells with Calcofluor, enabled us to quantify methyl ricinoleate droplet adhesion to cells precultured on a hydrophilic or on a hydrophobic carbon source. In this last case, droplet adsorption was enhanced and a MATS (microbial adhesion to solvents) test revealed that this increase was due to Lewis acid-base interactions and not to an increase in the hydrophobic properties of the cell surface. These preliminary results demonstrate that the developed cytometric method is promising for various applications concerning the study of interactions between microorganisms and an emulsified hydrophobic substrates. [less ▲]

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See detailHybrid magnetic equivalent circuit - finite element modelling of transformer fed electrical machines
Gyselinck, Johan; Dular, Patrick ULiege; Legros, Willy ULiege et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2003), 22(3), 643-658

This paper deals with the modelling of transformer supply in the two-dimensional (2D) finite element (FE) simulation of rotating electrical machines. Three different transformer models are compared The ... [more ▼]

This paper deals with the modelling of transformer supply in the two-dimensional (2D) finite element (FE) simulation of rotating electrical machines. Three different transformer models are compared The reference one is based on two 2D FE models, considering a cross-section either parallel or perpendicular to the laminations of the magnetic core. The parameters of the two other transformer models, a magnetic equivalent circuit and an electrical equivalent circuit, can be derived from the reference model Particular attention is paid to some common features of the transformer models, e.g. with regard to the inclusion of iron losses. The three models are used in the 2D FE simulation of the steady-state load operation and the starting from stand-still of an induction motor. [less ▲]

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See detailIntroduction of australian diploid cotton genetic variation into upland cotton
Ahoton, L.; Lacape, Jm.; Baudoin, Jean-Pierre ULiege et al

in Crop Science (2003), 43(6), 1999-2005

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See detailDe ereburgers. Een sociale geschiedenis van de Limburgse mijnwerkers
Geerkens, Eric ULiege

in Cahiers d'Histoire du Temps Présent = Bijdragen tot de Eigentijdse Geschiedenis (2003), 11

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See detail« ‘Soñar, recordar y vivir con eso’. Los sueños de los Záparas en la construcción del pasado, Amazonia Ecuatoriana »,
Bilhaut, Anne-Gaël ULiege

in Estudios Atacameños (2003), 26

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental ... [more ▼]

The ethnographic study of the Zápara case brings new and original data about memory building processes. The Amazonian Zápara achieve knowledge about their past through dreams that also have a fundamental role in their daily life. We will see how their history is constructed by means of dream experiences, and how these are used strategically in the present. Dreams, furthermore, guarantee the cultural and ritual continuity of this group on the verge of extinction. [less ▲]

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See detailConfronti piacentino-bergamaschi: alla ricerca delle radici emiliane della cultura figurativa dei Fantoni
Bugini, Mariaelena ULiege

in Atti dell'Ateneo di Scienze, Lettere ed Arti di Bergamo (2003), a.a. 2001/2002

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See detailEffet de la durée d’application d’un stimulus gravitationnel sur la formation de bois de tension et de bois opposé dans de jeunes pousses de peuplier (Populus euramericana cv ‘Ghoy’)
Jourez, Benoît ULiege; Avella-Shaw, Thomas

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60

De jeunes pousses de Peuplier Ghoy ont été maintenues artificiellement inclinées pendant des durées croissantes, afin d’induire la formation de tissus de bois de tension et de bois opposé en réaction au ... [more ▼]

De jeunes pousses de Peuplier Ghoy ont été maintenues artificiellement inclinées pendant des durées croissantes, afin d’induire la formation de tissus de bois de tension et de bois opposé en réaction au stimulus gravitationnel. Il apparaît que ces pousses sont susceptibles de percevoir et de réagir à un stimulus extrêmement bref à l’échelle d’une période de végétation. Après un temps de présentation de 6 heures, l’ensemble des pousses ont formé un arc de bois opposé. Toutefois, sur la face supérieure, un temps compris entre 24 et 48 heures est nécessaire pour qu’elles perçoivent la modification de leur état d’équilibre et se mettent à former du bois de tension. Après un temps de latence de 48 heures, la formation de fibres gélatineuses est déjà observée sur la face supérieure des tiges. L’augmentation de la durée du stimulus a des répercussions sur le nombre de fibres gélatineuses et sur l’angle d’ouverture de l’arc de bois de tension. Sur la face inférieure, les fibres de bois opposé se forment à un rythme moins soutenu, conduisant à une excentricité de la moelle dans la section de la tige. Le redressement des pousses est effectif après une durée de stimulus comprise entre 4 et 8 jours. [less ▲]

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See detailConceptual issues in 3D Urban GIS
Billen, Roland ULiege; Zlatanova, Siyka

in GIM International (2003), 17(1), 33-35

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See detailInfluence Molecular Arrangement in Self-assembled Monolayers on Adhesion Forces Measured by Chemical Force Microscopy
Duwez, Anne-Sophie ULiege; Jonas, Ulrich; Klein, Hubert

in Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry (2003), 4

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See detailAnalytic quantification of solar lentigines lightening by a 2% hydroquinone-cyclodextrin formulation.
Petit, Ludivine; Pierard, Gérald ULiege

in Journal of the European Academy of Dermatology & Venereology (2003), 17(5), 546-9

BACKGROUND: The innate melanin pigmentation of skin is modulated during lifetime by a series of factors, including ageing and chronic ultraviolet light exposure. Actinic lentigines may be of particular ... [more ▼]

BACKGROUND: The innate melanin pigmentation of skin is modulated during lifetime by a series of factors, including ageing and chronic ultraviolet light exposure. Actinic lentigines may be of particular concern from a cosmetic point of view. Conventional hypopigmenting agents are usually deceptive. Using cyclodextrins to form inclusion compounds with these agents might represent a more active drug delivery system. OBJECTIVE: To assess sensitive and objective methods predicting the effects of a 2% hydroquinone-cyclodextrin formulation on solar lentigines. STUDY DESIGN: Thirty Asian adults applied a 2% hydroquinone-cyclodextrin formulation once daily on solar lentigines of a forearm for 2 months. The other untreated forearm served as a control. Monthly assessments were performed using skin colorimetry and fluorescence video recording combined with image analysis. Corneomelametry following photodensitometry of cyanoacrylate skin surface strippings was performed after melanin staining of the samples. RESULTS: The control untreated solar lentigines showed no significant variations in the biometrological parameters. By contrast, the test formulation induced lightening of the solar lentigines. Corneomelametry disclosed improvement after 1 months' treatment, whereas the other assessments only reached significance after 2 months. CONCLUSIONS: A 2% hydroquinone-cyclodextrin formulation proved to be effective in lightening actinic lentigines. Corneomelametry predicted the effects discernible at a later stage by in vivo colour assessments of the melanin content. [less ▲]

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See detailInorganic and organic carbon biogeochemistry in the Gautami Godavari estuary (Andhra Pradesh, India) during pre-monsoon : the local impact of extensive mangrove forests
Bouillon, Steven; Frankignoulle, Michel; Dehairs, Frank et al

in Global Biogeochemical Cycles (2003), 17(4),

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the ... [more ▼]

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the oligohaline and mesohaline section (salinity 0–15) of the estuary, internal production of total alkalinity (TAlk) and dissolved inorganic carbon (DIC) was recorded, and the d13CDIC profile suggests that carbonate dissolution may be an important process determining the DIC dynamics in this section of the Godavari. The partial pressure of CO2 (pCO2) was fairly low along the entire salinity gradient, (293–500 ppm), but much higher and more variable (1375–6437 ppm) in the network of tidal mangrove creeks in the delta. Here, variations in the concentration and d13C of the DIC pool were shown to result largely from the mineralization of organic matter. The present study clearly identifies the mangrove creeks as an active site of mineralization and CO2 efflux to the atmosphere, but shows that these changes in the aquatic biogeochemistry are a localized feature, rapidly fading in the adjacent Kakinada Bay. Our data indicate that mineralization of dissolved organic carbon (DOC) of mangrove origin, and its subsequent efflux as CO2 to the atmosphere may represent an important fate for mangrove carbon. Although further quantification of this process in a variety of systems is required, we suggest that some of the current ideas on the role of mangroves in the carbon budget of the coastal zone may need to be reconsidered. [less ▲]

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See detailCalculation of optical absorption spectra of hydrogenated Si clusters: Bethe-Salpeter equation versus time-dependent local-density approximation
Benedict, L. X.; Puzder, A.; Williamson, A. J. et al

in Physical Review. B : Condensed Matter (2003), 68(8), 85310-1-85310-85310-885310-85310-8

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE ... [more ▼]

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE) with a model dielectric function, and the time-dependent density-functional theory within the adiabatic local-density approximation (TDLDA). Single-particle states are obtained from local-density approximation (LDA) calculations and, for the BSE calculation, a quasiparticle gap correction is provided by quantum Monte Carlo calculations. We find that the exchange-correlation kernel of the TDLDA has almost no effect on the calculated spectra, while the corresponding attractive part of the electron-hole interaction of the BSE produces enhanced absorptive features at low energies. For the smallest cluster SiH 4, the two methods produce markedly different results, with the TDLDA spectra appearing closer to the experimental result. The gross features of the TDLDA and BSE spectra for larger clusters are however similar, due to the strong repulsive Coulomb kernel present in both treatments [less ▲]

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See detailSalmonella contamination of pigs and pork in an integrated pig production system
Korsak Koulagenko, Nicolas ULiege; Jacob, Benoit; Groven, Bénédicte et al

in Journal of Food Protection (2003), 66(7), 1126-1133

This paper describes the monitoring of Salmonella in a closed pig production system in Belgium over a 2-year period. A sampling scheme including animal feeds and carcasses was designed to cover the entire ... [more ▼]

This paper describes the monitoring of Salmonella in a closed pig production system in Belgium over a 2-year period. A sampling scheme including animal feeds and carcasses was designed to cover the entire chain of production from farrow to finishing pigs. Salmonella was detected by a method based on the use of semisolid Rappaport-Vassiliadis as a selective medium. The serotypes of the isolated strains were determined, and the antibiotic resistance of these strains to six antibiotics was also investigated. Feeds were found to be more contaminated than expected (10.2%, 34 of 332 samples). The percentage of positive fecal samples for pregnant sows (8.1%, 11 of 135 samples) was significantly higher than that for young and lactating sows (2.9%, 11 of 378 samples) (P<0.05). The percentage of positive samples for colon contents collected at the slaughterhouse (47.3%, 88 of 186 samples) was significantly higher than that for feces collected during the fattening stage (5.6%, 18 of 320 samples) (P<0.001). For carcass swab samples, the observed prevalence was 11.2% (17 of 152 samples). On farms, Salmonella recovery levels were higher for overshoe samples than for fecal samples, except for pregnant sows. Salmonella Typhimurium was the most frequently isolated serotype (32.2%, 55 of 171 samples), while Salmonella Brandenburg was predominant in the colon contents collected at the abattoir (21.4%, 18 of 84 samples). Feeds harbored a wide diversity of serotypes of minor epidemiological significance. Of 55 isolated strains of Salmonella Typhimurium, 11 (20%) were resistant to tetracycline, ampicillin, choramphenicol, streptomycin, trimethoprim, and nalidixic acid (R Type TeAmCSNa), while 12 (21.8%) were resistant to all of these antibiotics except nalidixic acid (R Type TeAmCS). The majority of Salmonella Typhimurium strains that exhibited resistance to more than four antimicrobial agents were characterized as Salmonella Typhimurium DT104 or as being closely related to Salmonella Typhimurium DT104 (7 of 12 isolates). In conclusion, our system of surveillance is effective in identifying most points of contamination in the production chain and will be useful in ongoing efforts to develop a Salmonella-free production system. [less ▲]

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See detailGuided vortex motion in superconductors with a square antidot array
Silhanek, Alejandro ULiege; Van Look, L.; Raedts, S. et al

in Physical Review. B : Condensed Matter (2003), 68(21),

We have measured the in-plane anisotropy of the vortex mobility in a thin Pb film with a square array of antidots. The Lorentz force, acting on the vortices, was rotated by adding two perpendicular ... [more ▼]

We have measured the in-plane anisotropy of the vortex mobility in a thin Pb film with a square array of antidots. The Lorentz force, acting on the vortices, was rotated by adding two perpendicular currents and keeping the amplitude of the net current constant. One set of voltage probes was used to detect the vortex motion. We show that the pinning landscape provided by the square antidot lattice influences the vortex motion in two different ways. First, the modulus of the vortex velocity becomes angular dependent with a lower mobility along the diagonals of the pinning array. Second, the vortex displacement is preferentially parallel to the principal axes of the underlying pinning lattice, giving rise to a misalignment between the vortex velocity and the applied Lorentz force. We show that this anisotropic vortex motion is temperature dependent and progressively fades out when approaching the normal state. [less ▲]

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See detailObservations sous Mons, 25 mars 2002
Leleu, Yves-Henri ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailRadiothérapie métabolique des douleurs osseuses métastatiques
Hustinx, Roland ULiege; Sautois, Brieuc ULiege; Jerusalem, Guy ULiege et al

in Médecine et Hygiène (2003), 61

La radiothérapie métabolique des métastases osseuses est un traitement palliatif de la douleur. Cet objectif est rempli dans la grande majorité des cas, sans effets secondaires cliniquement ressentis par ... [more ▼]

La radiothérapie métabolique des métastases osseuses est un traitement palliatif de la douleur. Cet objectif est rempli dans la grande majorité des cas, sans effets secondaires cliniquement ressentis par le patient. Tous les patients en dissémination osseuse ne peuvent cependant bénéficier de cette approche qui, lorsqu'elle est choisie, doit toujours être appliquée dans un cadre multidisciplinaire. Les lésions accessibles à ce traitement doivent avoir démontré leur caractère ostéocondensant en scintigraphie. La fonction rénale et la réserve médullaire sont des paramètres importants, l'élimination des radiopharmaceutiques étant urinaire et leur toxicité, médullaire. Les situations particulières telles que risque fracturaire important ou compression médullaire sont des contre-indications. Le traitement est simple dans son principe et dans sa réalisation. Il permet une amélioration très significative de la qualité de vie, tout en réalisant des économies substantielles en terme de coût de santé publique. [less ▲]

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See detailClonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases.
Herens, Christian ULiege; Baron, Frédéric ULiege; Croisiau, Christiane et al

in Cancer Genetics & Cytogenetics (2003), 147(1), 78-80

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal ... [more ▼]

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal chromosomal aberrations in Philadelphia-negative (Ph-) cells during treatment has been reported. We describe two CML patients in chronic phase who presented with complete cytogenetic responses during imatinib mesylate therapy but developed new clonal chromosomal rearrangements in Ph- cells. The first patient presented with a duplication of chromosome 1, dup(1)(q21q42), and the second showed two new clonal aberrations consisting of inv(1)(q12q32) and del(7)(q22) in the same clone. [less ▲]

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See detailCatabolism of hydroxyacids and biotechnological production of lactones by Yarrowia lipolytica
Waché, Y.; Aguedo, Mario ULiege; Nicaud, J.-M. et al

in Applied Microbiology and Biotechnology (2003), 61(5-6), 393-404

The γ- and δ-lactones of less than 12 carbons constitute a group of compounds of great interest to the flavour industry. It is possible to produce some of these lactones through biotechnology. For ... [more ▼]

The γ- and δ-lactones of less than 12 carbons constitute a group of compounds of great interest to the flavour industry. It is possible to produce some of these lactones through biotechnology. For instance, γ-decalactone can be obtained by biotransformation of methyl ricinoleate. Among the organisms used for this bioproduction, Yarrowia lipolytica is a yeast of choice. It is well adapted to growth on hydrophobic substrates, thanks to its efficient and numerous lipases, cytochrome P450, acylCoA oxidases and its ability to produce biosurfactants. Furthermore, genetic tools have been developed for its study. This review deals with the production of lactones by Y. lipolytica with special emphasis on the biotransformarion of methyl ricinoleate to γ-decalactone. When appropriate, information from the lipid metabolism of other yeast species is presented. [less ▲]

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See detailThe Portugal coastal counter current off NW Spain: new insights on its biogeochemical variability
Alvarez-Salgado, Xosé Antón; Figueiras, F. G.; Perez, F. F. et al

in Progress in Oceanography (2003), 56(2), 281-321

Time series of wind-stress data, AVHRR and SeaWiFS satellite images, and in situ data from seven cruises are used to assemble a coherent picture of the hydrographic variability of the seas off the ... [more ▼]

Time series of wind-stress data, AVHRR and SeaWiFS satellite images, and in situ data from seven cruises are used to assemble a coherent picture of the hydrographic variability of the seas off the Northwest Iberian Peninsula from the onset (September-October) to the cessation (February-May) of the Portugal coastal counter current (PCCC). During this period the chemistry and the biology of the shelf, slope and ocean waters between 40degrees and 43degreesN have previously been undersampled. Novel information extracted from these observations relate to: 1. The most frequent modes of variability of the alongshore coastal winds, covering event, seasonal and long-term scales; 2. The conspicuous cycling between stratification and homogenisation observed in PCCC waters, which has key implications for the chemistry and biology of these waters; 3. The seasonal evolution of nitrite profiles in PCCC waters in relation to the stratification cycle; 4. The Redfield stoichiometry of the remineralisation of organic matter in Eastern North Atlantic Central Water (ENACW)-the water mass being transported by the PCCC; 5. The separation of coastal (mesotrophic) from PCCC (oligotrophic) planktonic populations by a downwelling front along the shelf, which oscillates to and fro across the shelf as a function of coastal wind intensity and continental runoff; and 6. The photosynthetic responses of the PCCC and coastal plankton populations to the changing stratification and light conditions from the onset to the cessation of the PCCC. [less ▲]

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See detailCompte-rendu de l'ouvrage de P. Buchholz : Psoriasis. Therapeutische Ansätze vom 18. bis zum 20. Jahrhundert
Nissen, Cécile ULiege

in Archives Internationales d'Histoire des Sciences (2003)

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See detailAnalyse de la variabilité spatio-temporelle de la morphologie du chenal de la Warche en amont du barrage de Butgenbach (Belgique).
Assani, A. A.; Petit, François ULiege; Buffin-Belanger, T. et al

in Zeitschrift für Geomorphologie (2003)

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See detailThéorie économique et marchandisation des services non marchands
Mertens de Wilmars, Sybille ULiege; Lefebvre, Mathieu ULiege

in Non Marchand : Management, Droit et Finance (2003), (11), 11-27

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See detailComment j'explore ... un trouble de la magnésémie
Boman, Xavier ULiege; Guillaume, Thierry; Krzesinski, Jean-Marie ULiege

in Revue Médicale de Liège (2003), 58(2), 104-108

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical ... [more ▼]

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical presentations and etiologies of hypo- and hypermagnesemia and their exploration. Hypomagnesemia frequently occurs but is clinically rarely recognized without biological serum ionic determinations because causing atypical signs miming those of other ion deficiencies. Hypermagnesemia is uncommon but often occurs in the presence of renal insufficiency especially with excess of Mg administration. [less ▲]

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See detailHDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.
Dequiedt, Franck ULiege; Kasler, Herbert; Fischle, Wolfgang et al

in Immunity (2003), 18(5), 687-98

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and ... [more ▼]

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and negative selection, via the transcription factor MEF2D. HDAC7 is exported from the nucleus during T cell receptor activation, leading to Nur77 expression. A triple HDAC7 mutant (S155A, S318A, S448A) is not exported from the nucleus in response to TCR activation and suppresses TCR-mediated apoptosis. Conversely, a fusion of HDAC7 to the transcriptional activator VP16 activates Nur77 expression. Inhibition of HDAC7 expression by RNA interference causes increased apoptosis in response to TCR activation. These observations define HDAC7 as a regulator of Nur77 and apoptosis in developing thymocytes. [less ▲]

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See detailA dip into the world of veterinary nuclear medicine: equine lung scintigraphy
Votion, Dominique ULiege; Lekeux, Pierre ULiege

in Clinical Techniques in Equine Practice (2003), 2(3), 222-230

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology ... [more ▼]

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology, for the knowledge of animal peculiarities, for the study and diagnosis of equine respiratory disorders as well as for the development of their treatment. This article surveys some methodological constraints due to the scanning of a noncooperative large-sized animal, reviews the contribution of equine nuclear imaging in lung physiology and pathology, and discusses future clinical and fundamental applications of lung scintigraphy. [less ▲]

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See detailQuels rôles et quelle formation pour les tuteurs intervenant dans des dispositifs de formation à distance ?
Denis, Brigitte ULiege

in Distances et Savoirs (2003), 1(1), 19-46

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif ... [more ▼]

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. [less ▲]

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