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See detailCysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.
Bounaga, S.; Galleni, Moreno ULg; Laws, A. P. et al

in Bioorganic & medicinal chemistry (2001), 9(2), 503-10

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion ... [more ▼]

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site. [less ▲]

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See detailUltrasonography of the Podotrochlear Apparatus in the Horse Using a Transcuneal Approach: Technique and Reference Images
Busoni, Valeria ULg; Denoix, Jean-Marie

in Veterinary Radiology & Ultrasound (2001), 42(6), 534-40

The purpose of this paper is to describe the technique for ultrasonographic examination of the podotrochlear apparatus in the horse using a transcuneal approach. In this study, ultrasound scans were ... [more ▼]

The purpose of this paper is to describe the technique for ultrasonographic examination of the podotrochlear apparatus in the horse using a transcuneal approach. In this study, ultrasound scans were performed in 3 normal cadaver limbs and 5 sound horses and images were compared to anatomic sections to establish the normal ultrasonographic anatomy of the podotrochlear apparatus. Detailed description of transverse and sagittal reference ultrasonographic images of this region is provided. This new imaging technique allows the assessment of the distal sesamoid bone flexor surface, the distal portion of the deep digital flexor tendon, the impar distal sesamoidean ligament, and the entheses of the distal phalanx. [less ▲]

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See detailStraylight tests for the Heliospheric imagers of STEREO
Defise, Jean-Marc ULg; Halain, Jean-Philippe ULg; Mazy, Emmanuel ULg et al

in ESA-SP (2001), 467

The design of the Heliospheric Imager (HI) of the NASA Solar TErrestrial Relations Observatory (STEREO) is based on an optical baffle system. It will reject the solar disk light with attenuation of the ... [more ▼]

The design of the Heliospheric Imager (HI) of the NASA Solar TErrestrial Relations Observatory (STEREO) is based on an optical baffle system. It will reject the solar disk light with attenuation of the order of 10-13 and 10-15, and let two separate camera systems (HI-1 and HI-2) measure the extremely faint solar coronal mass ejections. A multi-vane diffractive system has been optimized to achieve the lower requirement (10-13 for HI-1) and is combined with a secondary baffling system to reach the 10-15 rejection performance in the second camera system (HI-2). The theoretical performances of the baffling systems will be experimentally verified during the instrument development phase. A specific straylight test facility is being studied at CSL and preliminary tests have been conducted to prepare the HI instrument testing. The test set-up requirements and design considerations are discussed in this paper. The very high rejection performance requires to perform those tests under vacuum to avoid ambient air perturbations. Several light trapping systems have been developed for this application. A first breadboard has been built and is currently under testing. Preliminary results of those tests are presented. [less ▲]

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See detailL'expertise pénale en matière de responsabilité médicale
Boxho, Philippe ULg

in Consilio manuque (2001), 28

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See detailCharacterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties.
Franceschini, N.; Boschi, L.; Pollini, S. et al

in Antimicrobial agents and chemotherapy (2001), 45(12), 3509-16

A class D beta-lactamase determinant was isolated from the genome of Legionella (Fluoribacter) gormanii ATCC 33297(T). The enzyme, named OXA-29, is quite divergent from other class D beta-lactamases ... [more ▼]

A class D beta-lactamase determinant was isolated from the genome of Legionella (Fluoribacter) gormanii ATCC 33297(T). The enzyme, named OXA-29, is quite divergent from other class D beta-lactamases, being more similar (33 to 43% amino acid identity) to those of groups III (OXA-1) and IV (OXA-9, OXA-12, OXA-18, and OXA-22) than to other class D enzymes (21 to 24% sequence identity). Phylogenetic analysis confirmed the closer ancestry of OXA-29 with members of the former groups. The OXA-29 enzyme was purified from an Escherichia coli strain overexpressing the gene via a T7-based expression system by a single ion-exchange chromatography step on S-Sepharose. The mature enzyme consists of a 28.5-kDa polypeptide and exhibits an isoelectric pH of >9. Analysis of the kinetic parameters of OXA-29 revealed efficient activity (k(cat)/K(m) ratios of >10(5) M(-1) x s(-1)) for several penam compounds (oxacillin, methicillin, penicillin G, ampicillin, carbenicillin, and piperacillin) and also for cefazolin and nitrocefin. Oxyimino cephalosporins and aztreonam were also hydrolyzed, although less efficiently (k(cat)/K(m) ratios of around 10(3) M(-1) x s(-1)). Carbapenems were neither hydrolyzed nor inhibitory. OXA-29 was inhibited by BRL 42715 (50% inhibitory concentration [IC(50)], 0.44 microM) and by tazobactam (IC(50), 3.2 microM), but not by clavulanate. It was also unusually resistant to chloride ions (IC(50), >100 mM). Unlike OXA-10, OXA-29 was apparently found as a dimer both in diluted solutions and in the presence of EDTA. Its activity was either unaffected or inhibited by divalent cations. OXA-29 is a new class D beta-lactamase that exhibits some unusual properties likely reflecting original structural and mechanistic features. [less ▲]

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See detailCardiac surgery in octogenarians: who, when and how?
Pierard, Luc ULg

in European heart journal (2001), 22(14), 1159-61

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See detailN content of phloem and xylem exudates during the transition to flowering in Sinapis alba and Arabidopsis thaliana
Corbesier, Laurent; Havelange, Andrée ULg; Lejeune, Pierre et al

in Plant, Cell & Environment (2001), 24

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower ... [more ▼]

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower by one long day (LD). In S. alba, the phloem sap (leaf and apical exudates) and the xylem sap (root exudate) were analysed in LD versus SD. In A. thaliana, only the leaf exudate could be analysed but an alternative system for inducing flowering without day-length extension was used: the displaced SD (DSD). Significant results are: (i) in both species, the leaf exudate was enriched in Gln during the inductive LD, at a time compatible with export of the floral stimulus; (ii) in S. alba, the root export of amino acids decreased in LD, whereas the nitrate remained unchanged - thus the extra-Gln found in the leaf exudate should originate from the leaves; (iii) extra-Gln was also found very early in the apical exudate of S. alba in LD, together with more Glu; (iv) in A. thaliana induced by one DSD, the leaf export of Asn increased sharply, instead of Gln in LD. This agrees with Asn prevalence in C-limited plants. The putative role of amino acids in the transition to flowering is discussed. [less ▲]

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See detailAtomic transition probabilities in Bi II
Palmeri, P.; Quinet, Pascal ULg; Biémont, Emile ULg

in Physica Scripta (2001), 63

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See detailMicro-analyse des mécanismes de la reprise démographique des villages de l'Ardenne du Nord-Est : le cas de Burtonville
Schmitz, Serge ULg

in Espace, Populations, Sociétés (2001)

If they are well selected, macro scale analyses permit to underline some mechanisms that remain hidden or are difficult to distinguish with micro scale analysis. The populations' stories an history of ... [more ▼]

If they are well selected, macro scale analyses permit to underline some mechanisms that remain hidden or are difficult to distinguish with micro scale analysis. The populations' stories an history of Burtonville in their regional context show : - lags of demographic revivals between villages and small towns - relevance of material constraints inherent in a small village for the demographic development - relevance of landed property and genealogy for the village evolution - links between demographic and economic evolutions - diversification of environmental aspirations and their results on migrations. [less ▲]

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See detailWhen should triptans be taken during a migraine attack?
Schoenen, Jean ULg

in CNS Drugs (2001), 15(8), 583-7

The common strategy to treat a migraine attack as soon as it begins, made for classical acute antimigraine treatments such as ergotamine and analgesics, has not been transposed to the triptans. The ... [more ▼]

The common strategy to treat a migraine attack as soon as it begins, made for classical acute antimigraine treatments such as ergotamine and analgesics, has not been transposed to the triptans. The recommendation to delay triptan intake until headache intensity is at least moderate is merely a habit generated by the protocol used in triptan trials and a nonvalidated attempt to reduce costs. It is also favoured by the few studies suggesting that sumatriptan is less effective when given early in an attack, especially during the aura phase. Recent retrospective analyses of small numbers of 'protocol violators' in controlled trials of sumatriptan suggest that the drug is more efficient when taken while the headache is mild. Pain-free responses and therapeutic gains over aspirin (acetylsalicylic acid)-metoclopramide or ergotamine-caffeine combinations were increased under these conditions. The available circumstantial evidence is reviewed and discussed. Before any conclusion can be drawn and recommendation made, results are awaited from randomised controlled trials specifically addressing whether or not triptans are more efficient in mild headache. Meanwhile, there seems to be no medical reason to withhold treatment of a mild headache with a triptan as long as triptan intake does not exceed 1 or 2 doses per week. Most mild headaches in patients with migraine appear indeed to be mild migraine attacks, even when the headache characteristics are those of tension-type headache. [less ▲]

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See detailCalculated transition probabilities in highly charged Ti-like ions
Biémont, Emile ULg; Träbert, E.; Zeippen, C. J.

in Journal of Physics : B Atomic Molecular & Optical Physics (2001), 34

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See detailThe European Continental Shelf as a Significant sink for Atmospheric Carbon Dioxide
Frankignoulle, Michel; Borges, Alberto ULg

in Global Biogeochemical Cycles (2001), 15(3), 569-576

The concentration of carbon dioxide was measured during 18 cruises in the surface waters of the North Atlantic European Shelf (Galician sea, Gulf of Biscay, Armorican Sea, Celtic Sea, English Channel ... [more ▼]

The concentration of carbon dioxide was measured during 18 cruises in the surface waters of the North Atlantic European Shelf (Galician sea, Gulf of Biscay, Armorican Sea, Celtic Sea, English Channel, North Sea), covering all four seasons (9 months of 12) at interannual scale. This is the very first intensive field study of continental shelves, in terms of source/sink for atmospheric CO2, which allows to integrate fluxes on an annual basis and over a large surface area. Here we show that European continental shelves are a sink of 90 to 170 million tons of carbon per year, that is an additional appreciable fraction to the presently proposed flux for the open North Atlantic Ocean (about 45%). The air-sea fluxes of CO2 we obtained are similar to those recently reported in the East China Sea, allowing us to conclude that the coastal ocean plays a considerable role in the global oceanic carbon cycle. [less ▲]

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See detailAnaesthesia for laparoscopic surgery
Kaba, Abdourahmane ULg; Joris, Jean ULg

in Current Anaesthesia and Critical Care (2001), 12

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See detailOn the sources of work hardening in multiphase steels assisted by transformation-induced plasticity
Jacques, Pascal J.; Furnémont, Quentin; Mertens, Anne ULg et al

in Philosophical Magazine A (2001), 81(7), 1789-1812

The mechanisms effectively responsible for the enhancement of the work-hardening capabilities of multiphase steels assisted by transformation-induced plasticity are highlighted. Different microstructures ... [more ▼]

The mechanisms effectively responsible for the enhancement of the work-hardening capabilities of multiphase steels assisted by transformation-induced plasticity are highlighted. Different microstructures, some containing a proportion of retained austenite with various mechanical stabilities, are studied. The dislocation density generated within ferrite by the mechanically induced martensitic transformation of retained austenite is shown to scale with the incremental work-hardening exponent. The acoustic emission generated during tensile straining was also measured. The acoustic emission was revealed to result mainly from dislocation motion, especially from the motion of the additional dislocation density generated in intercritical ferrite by the strain-induced martensitic transformation. [less ▲]

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See detailObesity: causes and new treatments.
Lefebvre, Pierre ULg; Scheen, André ULg

in Experimental & Clinical Endocrinology & Diabetes (2001), 109 Suppl 2

The prevalence of obesity increases rapidly in developed and developing countries. Obesity results from a cumulative positive energy balance and is favoured by both genetic and environmental factors ... [more ▼]

The prevalence of obesity increases rapidly in developed and developing countries. Obesity results from a cumulative positive energy balance and is favoured by both genetic and environmental factors. Preventing obesity requires a major investment in nutritional and lifestyle education, particularly in children and adolescents.--The pharmacological approach to obesity includes drugs that reduce food intake (noradrenergic and serotoninergic agents), drugs that increase energy expenditure and compounds that affect nutrient partitioning. In all instances, the benefit-to-risk ratio needs to be carefully assessed. In some patients (severe obesity or obesity accompanied by serious high-risk comorbid conditions), gastric surgery (gastric restriction or gastric bypass) should be considered. In our own experience, it is safe and effective. [less ▲]

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See detailDynamique de modification de l'habitat physique de reproduction des pondeurs lithophiles sous gravier. Cas de deux frayères à ombre dans l'Aisne
Parkinson, Denis; Petit, François ULg; Houbrechts, Geoffrey ULg et al

in Bulletin de la Société Géographique de Liège (2001), 40

D’octobre 1998 à mars 1999, nous avons étudié dans l’Aisne, petit affluent ardennais de l’Ourthe, la dynamique de modification de deux bancs de gravier utilisés comme frayère par l’ombre commun en mars ... [more ▼]

D’octobre 1998 à mars 1999, nous avons étudié dans l’Aisne, petit affluent ardennais de l’Ourthe, la dynamique de modification de deux bancs de gravier utilisés comme frayère par l’ombre commun en mars-avril 1998. L’étude a été réalisée dans deux stations du cours inférieur de l’Aisne où se sont succédé quatre crues morphogènes. Dans chaque station, nous avons déterminé à intervalle d’environ 1 mois, la profondeur d’érosion et la hauteur de dépôt des sédiments (méthode de la barre d’érosion à chaînes), la granulométrie des matériaux des couches de surface et de subsurface, le dépôt des sédiments fins (placement de pièges à sédiments) et la perméabilité du substrat (méthode du standpipe). En complément, nous avons entrepris dans une station de l’Aisne moyenne, une caractérisation de divers éléments de la dynamique fluviale : identification des débits mobilisateurs (par marquage colorimétrique des sédiments en place), estimation de la vitesse de déplacement de la charge de fond (par étude de la dispersion longitudinale de scories, résidu d’anciennes industries métallurgiques) et estimation des quantités de sédiments charriés par la rivière (à partir des données de dragage). [less ▲]

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See detailLe cas clinique du mois. Remplacement complet de l'aorte ascendante et de la crosse aortique dans un cas de dissection aortique chronique
DURIEUX, Rodolphe ULg; RADERMECKER, Marc ULg; GRENADE, Thierry ULg et al

in Revue Médicale de Liège (2001), 56(3), 140-3

We report the case of a patient who developed an evolutive chronic aortic dissection after ascending aorta replacement for acute type A aortic dissection. Owing to the development of severe aortic ... [more ▼]

We report the case of a patient who developed an evolutive chronic aortic dissection after ascending aorta replacement for acute type A aortic dissection. Owing to the development of severe aortic regurgitation, aortic root pseudoaneurysm and aneurysmal dilatation of the arch and descending aorta, reoperation was adviced. Reoperation included Cabrol modification of the Bentall operation and aortic arch replacement with elephant trunk performed under deep hypothermic circulatory arrest. The incidence of late aneurysmal formation in type 1 aortic dissection has been reported to be 30%. Close postoperative follow-up of the aortic diameter is necessary to detect a critical dilatation and to permit elective reoperation. [less ▲]

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See detail(R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide mono-hydrate
Dupont, L.; De Tullio, Pascal ULg; Tinant, B. et al

in Acta Crystallographica (2001), E57

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See detailComparison by image processing of target supports of spray droplets
Degre, Aurore ULg; Mostade, Olivier; Huyghebaert, Bruno et al

in transaction of the American society of Agricultural engineers (2001), 44(2), 217-222

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See detailExperimental and Theoretical Energy Levels, Transition probabilities and Radiative Lifetimes in Yb III
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Li, Z. S. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (2001), 34

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See detailExperimental Hafting Traces. Identification and Characteristics
Rots, Veerle ULg; Pirnay, Louis; Pirson, Philippe et al

in Notae Praehistoricae (2001), 21

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See detailAutosomal recessive segregation of a truncating mutation of anti-Mullerian type II receptor in a family affected by the persistent Mullerian duct syndrome contrasts with its dominant negative activity in vitro.
Messika-Zeitoun, L.; Gouedard, L.; Belville, C. et al

in Journal of Clinical Endocrinology and Metabolism (2001), 86(9), 4390-7

Anti-Mullerian hormone belongs to the TGFbeta family whose members exert their effects by signaling through two related serine/threonine kinase receptors. Mutations of the anti-Mullerian hormone type II ... [more ▼]

Anti-Mullerian hormone belongs to the TGFbeta family whose members exert their effects by signaling through two related serine/threonine kinase receptors. Mutations of the anti-Mullerian hormone type II receptor occur naturally, causing the persistent Mullerian duct syndrome. In a family with two members with persistent Mullerian duct syndrome and one normal sibling, we detected two novel mutations of the anti-Mullerian hormone type II receptor gene. One, transmitted by the mother to her three sons, is a deletion of a single base leading to a stop codon, causing receptor truncation after the transmembrane domain. The other, a missense mutation in the substrate-binding site of the kinase domain, is transmitted by the father to the two sons affected by persistent Mullerian duct syndrome, indicating a recessive autosomal transmission as in other cases of persistent Mullerian duct syndrome. Truncating mutations in receptors of the TGFbeta family exert dominant negative activity, which was seen only when each of the mutant anti-Mullerian hormone receptors was overexpressed in an anti-Mullerian hormone-responsive cell line. We conclude that assessment of dominant activity in vitro, which usually involves overexpression of mutant genes, does not necessarily produce information applicable to clinical conditions, in which mutant and endogenous genes are expressed on a one to one basis. [less ▲]

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See detailMaxbias curves of robust scale estimators based on subranges
Croux, C.; Haesbroeck, Gentiane ULg

in Metrika (2001), 53(2), 101-122

A maxbias curve is a powerful tool to describe the robustness of an estimator. It is an asymptotic concept which tells how much an estimator can change due to a given fraction of contamination. In this ... [more ▼]

A maxbias curve is a powerful tool to describe the robustness of an estimator. It is an asymptotic concept which tells how much an estimator can change due to a given fraction of contamination. In this paper, maxbias curves are computed for some univariate scale estimators based on subranges: trimmed standard deviations, interquantile ranges and the univariate Minimum Volume Ellipsoid (MVE) and Minimum Covariance Determinant (MCD) scale estimators. These estimators are intuitively appealing and easy to calculate. Since the bias behavior of scale estimators may differ depending on the type of contamination (outliers or inliers), expressions for both explosion and implosion maxbias curves are given. On the basis of robustness and efficiency arguments, the MCD scale estimator with 25% breakdown point can be recommended for practical use. [less ▲]

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See detailLand-cover change: quantification metrics for perforation using 2-D gap features.
Bogaert, Jan ULg; Salvador-Van Eysenrode, D; Van Hecke, P et al

in Acta Biotheoretica (2001), 49(3), 161-169

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See detailIncrease of Plasma Ecg Binding Rate after Administration of Repeated High Dose of Ecg to Cows
Drion, Pierre ULg; De Roover, R.; Houtain, J. Y. et al

in Reproduction Nutrition Development (2001), 41(3), 207-215

Equine chorionic gonadotrophin (eCG) is still used to promote follicular growth in cattle and, more recently with an increased frequency of administration, in ovum pick-up protocols. The aim of this ... [more ▼]

Equine chorionic gonadotrophin (eCG) is still used to promote follicular growth in cattle and, more recently with an increased frequency of administration, in ovum pick-up protocols. The aim of this experiment was to verify the possible effect of high frequency of administration on the immune response to eCG. The profiles of eCG binding rate, in the blood of two groups (A, B) of 4 primiparous cross breed beef cows (3-3.5 years old) submitted weekly for 5 to 10 weeks to repeated high doses (1000-2000 IU) of equine chorionic gonadotrophin, are presented in this paper. A sensitive radiometric method was used to detect antibodies in plasma. The profiles clearly indicated a marked increase of eCG binding rate after 3 to 5 injections of the exogenous hormone to the females. The statistical analysis of the results established that treatments induced a significant increase (P < 0.01) in binding rates after 6 and 3 injections in group A and B respectively. These binding rates remained elevated for at least 1 week following the last injection and decreased afterwards. The values of plasma binding rates following repeated eCG administration differed significantly between groups (0.90+/-1.04 and 1.04+/-0.11 for groups A and B before treatment versus 11.77+/-0.92, 6.70+/-0.85 for groups A and B after treatment, P < 0.01) and from one cow to another (P < 0.01) with some cows presenting no significant immune response while others were more reactive against the hormone (at least 3 injections). [less ▲]

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See detailReduced excitability of the motor cortex in untreated patients with de novo idiopathic “grand mal” seizures
Delvaux, Valérie ULg; Alagona, Giovanna; GERARD, Pascale ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2001), 71(6), 772-776

OBJECTIVES: Transcranial magnetic stimulation (TMS) was used to investigate motor cortex excitability, intracortical excitatory, and inhibitory pathways in 18 patients having experienced a first "grand ... [more ▼]

OBJECTIVES: Transcranial magnetic stimulation (TMS) was used to investigate motor cortex excitability, intracortical excitatory, and inhibitory pathways in 18 patients having experienced a first "grand mal" seizure within 48 hours of the electrophysiological test. All had normal brain MRI, and were free of any treatment, drug, or alcohol misuse. Results were compared with those of 35 age matched normal volunteers. METHODS: The following parameters of responses to TMS were measured: motor thresholds at rest and with voluntary contraction, amplitudes of responses, cortical silent periods, and responses to paired pulse stimulation with interstimulus intervals of 1 to 20 ms. RESULTS: In patients, there were significantly increased motor thresholds with normal amplitudes of motor evoked potentials (MEPs), suggesting decreased cortical excitability. Cortical silent periods were not significantly different from those of normal subjects. Paired TMS with short interstimulus intervals (1-5 ms) induced normal inhibition of test MEPs, suggesting preserved function of GABAergic intracortical inhibitory interneurons. On the contrary, the subsequent period of MEP facilitation found in normal subjects (ISIs of 6-20 ms) was markedly reduced in patients. This suggests the existence of abnormally prolonged intracortical inhibition or deficient intracortical excitation. In nine patients retested 2 to 4 weeks after the initial seizure, these abnormalities persisted, although to a lesser extent. CONCLUSION: The present findings together with abnormally high motor thresholds could represent protective mechanisms against the spread or recurrence of seizures. [less ▲]

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See detailA Local Influence Approach to Sensitivity Analysis of Incomplete Longitudinal Ordinal Data
Van Steen, Kristel ULg; Molenberghs, G.; Verbeke, G. et al

in Statistical Modelling : An International Journal (2001), 1

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See detailSynthesis and characterisation of a quinolinonic compound activating ATP-sensitive K+ channels in endocrine and smooth muscle tissues
Becker, B.; Antoine, M.-H.; Nguyen, Q.-A. et al

in British Journal of Pharmacology (2001), 134

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See detailSémiotique et sciences cognitives : une mise en contexte
Badir, Sémir ULg

in Bulletin de l'Association française de sémiotique (2001), 1

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See detail7-Chloro-2-methyl-3-methylamino-2H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Somers, F.; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detailEmissions gazeuses en élevage porcin et modes de réduction : revue bibliographique
Degre, Aurore ULg; Verheve, Didier; Debouche, Charles ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(3), 135-143

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See detailMémoire à court terme et pathologies du langage
Poncelet, Martine ULg; Majerus, Steve ULg; Van der Linden, Martial ULg

in Rééducation Orthophonique (2001), 208

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See detailThe Developments of Cold-rolled TRIP-assisted Multiphase Steels. Al-alloyed TRIP-assisted Multiphase Steels
Jacques, Pascal J.; Girault, Etienne; Mertens, Anne ULg et al

in ISIJ International (2001), 41(9), 1068-1074

The influence of heat-treating conditions on the retention of carbon-enriched austenite of TRIP-assisted multiphase steel grades containing different amounts of silicon and/or aluminium is investigated ... [more ▼]

The influence of heat-treating conditions on the retention of carbon-enriched austenite of TRIP-assisted multiphase steel grades containing different amounts of silicon and/or aluminium is investigated. The ensuing mechanical properties resulting from the TRIP effect are also scrutinised. The bainite transformation kinetics was followed by dilatometry whereas a detailed characterisation of the microstructures led to the construction off transformation maps giving the volume fractions of the different phases and the carbon content of the austenite. The role of silicon and aluminium additions (i)on the retention of austenite by partial bainite transformation and (ii) on the mechanical properties is enlightened. A strong influence of the solid-solution strengthening effect of silicon is highlighted. Aluminium seems to be an effective alloying element for the retention of austenite in TRIP-aided steels even if lower strength levels can be attained. A mixed Al-Si TRIP-aided steel seems to be a very good compromise between the processing needs, the required mechanical properties and the industrial constraints. [less ▲]

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See detailAll detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis.
Amoroso, Ana Maria ULg; Demares, D.; Mollerach, M. et al

in Antimicrobial agents and chemotherapy (2001), 45(7), 2075-81

All detectable high-molecular-mass penicillin-binding proteins (HMM PBPs) are altered in a clinical isolate of Streptococcus mitis for which the beta-lactam MICs are increased from those previously ... [more ▼]

All detectable high-molecular-mass penicillin-binding proteins (HMM PBPs) are altered in a clinical isolate of Streptococcus mitis for which the beta-lactam MICs are increased from those previously reported in our region (cefotaxime MIC, 64 microg/ml). These proteins were hardly detected at concentrations that saturate all PBPs in clinical isolates and showed, after densitometric analysis, 50-fold-lower radiotracer binding. Resistance was related to mosaic structure in all HMM PBP-coding genes, where critical region replacement was complemented not only by substitutions already reported for the closely related Streptococcus pneumoniae but also by other specific replacements that are presumably close to the active-site serine. Mosaic structure was also presumed in a pbp1a-sensitive strain used for comparison, confirming that these structures do not unambiguously imply, by themselves, detectable critical changes in the kinetic properties of these proteins. [less ▲]

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See detailResponsabilité pénale et faute pénale
Boxho, Philippe ULg

in Revue Médicale de Liège (2001), 56

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See detailRe-inventing the wheel or adding one to the headache pathogenesis vehicle.
Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (2001), 21(8), 796-7

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See detail3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detailLa prescription extinctive en droit du travail
Kefer, Fabienne ULg; Clesse, Jacques ULg

in Journal des Tribunaux du Travail (2001)

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See detailWave packet methods for charge exchange processes in ion-atom collision
Baloïtcha, Ezinvy; Desouter, Michèle ULg; Bacchus-Montabonel, Marie-Christine et al

in Journal of Chemical Physics (2001), 114

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See detailTetraethyl(Pyrrolidine-2,2-diyl)Bisphosphonate
Olive, Gilles ULg; Jacques, Alain

in Molecules (2001), 6

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See detailPIT-1, a candidate gene for mass assisted selection in dairy bulls.
Parmentier, Isabelle; Gengler, Nicolas ULg; Fontaine, S. et al

in Journal of Animal Science (2001), 79(Suppl 1, N°1412), 340

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See detailNews on antifungal drugs registered in Belgium for the treatment of dermatophytosis in domestic carnivores.
Hamoir, J.; Goret, M.; Mignon, Bernard ULg et al

in Annales de Médecine Vétérinaire (2001), 145

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the ... [more ▼]

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the therapeutic protocols used in this type of diseases but rather to describe these compounds according to their pharmacological and toxicological characteristics as well as to define their status in the current legal framework. [less ▲]

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See detailMolecular certification in chicken meat channel.
Haezebroeck, Valérie; Renaville, Robert ULg; Parmentier, Isabelle et al

in Journal of Animal Science (2001), 79(Suppl 1 N°1072), 260

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See detailQualité des soins et qualité de vie des enfants atteients de pathologies anorectales et de leurs familles
Noirhomme-Renard, Florence ULg

in Bulletin d'Education du Patient à sa Maladie (2001)

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See detailDevelopment of specific antibodies for the quantificaion of plasma insulin-like growth factor-binding protein-3 in cattle.
Renaville, Robert ULg; Bertozzi, C.; Hetzel, S. et al

in Journal of Animal Science (2001), 79(suppl 1, N°1610), 388

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See detailAPRIL IN CHICAGO
Sacré, Robert ULg

in Soul Bag (2001), (163), 50

The Center for Black Music Research sur le web . Scènes du blues et du gospel

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See detailOrdovician cryptospores from the Oostduinkerke borehole, Brabant Massif, Belgium
Steemans, Philippe ULg

in Geobios (2001), 34(1), 3-12

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See detailGiacomo Leopardi e Francesco Guicciardini
Moreno, Paola ULg

in Studi e Problemi di Critica Testuale (2001), LXII

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See detailSperm size and number variation in the red flour beetle
Arnaud, Ludovic; Haubruge, Eric ULg; Gage, Matthew

in Zoological Journal of the Linnean Society (2001), 133

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See detailFactors inftuencing ribavirin-induced hemolysis
Van Vlierberghe, H.; Delanghe, J. R.; De Vos, M. et al

in Journal of Hepatology (2001), 34

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study ... [more ▼]

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study tried to search for these variables in a large group of patients with hepatitis C treated with the combination therapy. Methods: Two hundred and forty-four patients chronically infected with the hepatitis C virus were treated either with induction treatment (daily dose ofinterferon) or with a standard treatment (interferon thrice weekly). Both groups received 1000-1200 mg of ribavirin from week 4 until the end of the treatment. The drop in hemoglobin level was defined as the dift'erence between the pretreatment hemoglobin level and the hemoglobin level at week 8. Seventeen variables which could possibly influencê'this drop in hemoglobin level were examined. Results: After multivariate analysis, the drop in hemoglobin level was only significant influenced by pretreatment platelet level, treatment and haptoglobin phenotype. The ribavirin dose did not influence the drop in hemoglobin level or the early virological response. Conclusions: Ribavirin-induced hemolysis is inftuenced by the pretreatment platelet level, the administered amount of a-interferon and the haptoglobin phenotype. A careful search for the minimal dose of ribavirin needed in combination treatment is necessary. [less ▲]

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See detailRemission of severe cold agglutinin disease after Rituximab therapy.
LAYIOS, Nathalie ULg; Van Den Neste, E.; Jost, E. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2001), 15(1), 187-8

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See detailRecommandations for the registration of drugs used in the treatment of osteoarthritis : an update on biochemical markers
Vignon, E; Gamero, P; Delmas, P et al

in Osteoarthritis and Cartilage (2001), 9

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See detailThe role of integrins in human embryo implantation
Merviel, P.; Challier, J. C.; Carbillon, L. et al

in Fetal Diagnosis & Therapy (2001), 16(6), 364-371

Integrins are adhesion molecules present in endometrial, decidual, and extravillous cytotrophoblast (EVCT) cells. They participate in cell-cell adhesion as well as in adhesion between cells and components ... [more ▼]

Integrins are adhesion molecules present in endometrial, decidual, and extravillous cytotrophoblast (EVCT) cells. They participate in cell-cell adhesion as well as in adhesion between cells and components of the extracellular matrix, and they play an important role in the endometrial phenotype change that occurs during the secretory phase, the first stage of implantation. At the beginning of pregnancy, the change in integrin expression is synchronized with the trophoblast attachment (embryo-endometrium interactions with integrins v3, 41, 61, and 71) and the embryo's invasion of the decidua (integrins 64511141 switch from proliferative to endovascular EVCT). Several diseases, including preeclampsia, intrauterine growth retardation caused by vascular problems and defective luteal phases, may be explained by anomalies in integrin patterns. [less ▲]

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See detailComparative study of twenty nine non parametric interaction tests in two-way layouts
Van Belle, Laurent; Claustriaux, Jean-Jacques ULg

in Multiciência (2001), 4(2), 179-196

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See detailRobust Validation of Measurements on jet Engines
Dewallef, Pierre ULg; Léonard, Olivier ULg

in European Journal of Mechanical and Environmental Engineering (2001), 46(4), 237-242

Nowadays, most of turbine engine tests are processed using an open loop, i.e. the measurements are verified and treated a posteriori, sometimes weeks or months after the end of the test. The scope of the ... [more ▼]

Nowadays, most of turbine engine tests are processed using an open loop, i.e. the measurements are verified and treated a posteriori, sometimes weeks or months after the end of the test. The scope of the present project is to develop a new methodology which enables real time detection of faulty measurements and the suppression of the source of these faults during the test. This implies the development of a method which is sufficiently robust to cope with a lot of faulty data (up to 20 to 30 % of the measurements). Most of the existing methods make use of a least square approach so that a set of parameters is sought which minimizes the RMS error between the measurements and the values provided by a numerical model of the installation. This type of approach is efficient in finding whether a set of measurements is valid but cannot locate the fault(s). In this paper an alternative is proposed based on a distribution of the measurement noise introduced by Huber. This so-called robust validation method has been tested on a single spool, single flow and variable geometry nozzle turbojet. Both the least square and Huber's function approaches have been tested and compared in terms of efficiency. The robust estimator based on Huber's error function has shown to be much more powerful for both finding an invalid set of measurements and locating the faulty measurements. [less ▲]

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See detailLiver transplantation for hepatitis B virus infection: improving long-term outcomes
Detry, Olivier ULg; Delwaide, Jean ULg

in Medscape Transplantation (2001)

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See detailCrystallization and preliminary X-ray analysis of a bacterial psychrophilic enzyme, phosphoglycerate kinase
Mandelman, D.; Bentahir, M.; Feller, Georges ULg et al

in Acta Crystallographica Section D-Biological Crystallography (2001), 57(Pt 11), 1666-8

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and ... [more ▼]

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and decreased thermostability relative to its mesophilic counterpart. Herein, the preliminary crystallization and structure solution of psychrophilic PGK in its native form and cocrystallized with 3-phosphoglyceric acid (3-PGA) and the ATP analogue adenylyl imidophosphate (AMP-PNP) is reported. The complexed form of PGK crystallized in 2-3 d at 290 K, whereas the native form of the enzyme required 8-12 months. Morphologically, both crystal forms are similar and X-ray diffraction experiments indicate that the crystals are isomorphous. The crystals diffracted to a resolution of 2.0 A and belong to the space group P3(2). with unit-cell parameters a = b = 58.5, c = 85.4 A. [less ▲]

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See detailAlternative mating tactics in the alpine newt Triturus alpestris alpestris
Denoël, Mathieu ULg; Poncin, Pascal ULg; Ruwet, Jean-Claude

in Journal of Herpetology (2001), 35(1), 62-67

Sexual behaviors in dyadic encounters in the alpine newt, Triturus alpestris alpestris, is described to test whether male behavior is influenced by external cues, that is, female responsiveness. Depending ... [more ▼]

Sexual behaviors in dyadic encounters in the alpine newt, Triturus alpestris alpestris, is described to test whether male behavior is influenced by external cues, that is, female responsiveness. Depending on this factor, a male exhibits one of the two following tactics during the sperm transfer phase. The male either waits for a positive response from the female before initiating sperm transfer ("waiting" tactic), or creeps and deposits a spermatophore in front of a nonresponsive female ("luring" tactic). The sperm transfer success rates of these tactics are 31% and 6%, respectively,and encounter success rates, 64% and 8%, respectively. The success of the second tactic is linked to behaviors that lure the female, notably quiver and distal lure. The same individual can exhibit both tactics, and neither body size nor condition appears to influence the tactic a male exhibits. These tactics can be interpreted as the result of a conditional strategy, that is, a strategy that allows an individual to incorporate information about its ability to obtain fitness through alternative tactics and then express the tactic that maximizes its fitness. More particularly, these tactics are examples of a side-payment strategy, that is, a strategy that allows individuals to achieve small gains by capitalizing on passing opportunities. [less ▲]

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See detailUnimolecular reaction dynamics from kinetic energy release distributions. 8. Protonated fluorobenzene and structure of the phenyl ion
Lorquet, Jean-Claude ULg; Lorquet, Andrée

in Journal of Physical Chemistry A (2001), 105(15), 3719-3724

A previous interpretation of the kinetic energy release distribution (KERD) observed in the fragmentation of protonated fluorobenzene is confirmed by a maximum entropy analysis. The KERD is bimodal, with ... [more ▼]

A previous interpretation of the kinetic energy release distribution (KERD) observed in the fragmentation of protonated fluorobenzene is confirmed by a maximum entropy analysis. The KERD is bimodal, with an intense and broad component due to the production of the cyclic phenyl ion. Ab initio calculations indicate the existence of several open-chain isomers, with an energy about 1.0-1.2 eV higher than that of the phenyl ring. A weaker component of the KERD corresponds to the formation of one or several of these acyclic structures. Its abundance represents about 6% of the main component (but drops down to 3% for the perdeuterated isomer). More translational energy than the statistical estimate is released during the dissociation process because of the presence of a barrier along the reaction path leading to the generation of the cyclic phenyl ion. About one-half of the energy of the barrier is released as translation, thereby indicating the operation of strong exit-channel interactions between separating fragments. © 2001 American Chemical Society. [less ▲]

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See detailThe metropolis-hastings algorithm, a handy tool for the practice of environmental model estimation : illustration with the biochemical oxygen demand data
Torre, F.; Boreux, Jean-Jacques ULg; Parent, E.

in Cybergeo : Revue Européenne de Géographie = Cybergeo - European Journal of Geography (2001), 187

Environmental scientists often face situations where: (i) stimulus-response relationships are non-linear; (ii) data are rare or imprecise; (iii) facts are uncertain and stimulus-responses relationships ... [more ▼]

Environmental scientists often face situations where: (i) stimulus-response relationships are non-linear; (ii) data are rare or imprecise; (iii) facts are uncertain and stimulus-responses relationships are questionable.In this paper, we focus on the first two points. A powerful and easy-to-use statistical method, the Metropolis-Hastings algorithm, allows the quantification of the uncertainty attached to any model response. This stochastic simulation technique is able to reproduce the statistical joint distribution of the whole parameter set of any model. The Metropolis-Hastings algorithm is described and illustrated on a typical environmental model: the biochemical oxygen demand (BOD). The aim is to provide a helpful guideline for further, and ultimately more complex, models. As a first illustration, the MH-method is also applied to a simple regression example to demonstrate to the practitioner the ability of the algorithm to produce valid results. [less ▲]

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See detailPhenotypic analysis of strains deleted for genes with unknown function: data and general reasoning.
Bianchi, M.; Sartori, G.; Vandenbol, Micheline ULg et al

in Yeast (Chichester, England) (2001), 18(S97), 5-31

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See detailNew Chinese Migrants in Europe : The case of the Chinese community in Hungary
Florence, Eric ULg

in Nationalism & Ethnic Politics (2001), Vol. 7(Issue 1),

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See detailCommerce de détail, loisirs et tourisme : vers un renforcement des liens ?
Merenne-Schoumaker, Bernadette ULg

in Hommes et Terres du Nord (2001), (2001/2), 90-96

The aim of this article is to analyze the recent evolution of the links between the retail trade and the activities of leisures and tourism. For this purpose, work was organized in three times: initially ... [more ▼]

The aim of this article is to analyze the recent evolution of the links between the retail trade and the activities of leisures and tourism. For this purpose, work was organized in three times: initially, studying of the effects induced on the retail trade by tourism and the leisures; then, analyzing of two new forms of trade (shopping centres and factory outlets malls) which seem today to Induce displacements of leisure and tourism to the same title sometimes as some city centers; then searching for an explanation. For us, the emergence of the places of trade as " entertaining resources " results from increasingly strong convergence on certain places of new waitings of the consumers and the charac-teristics of the offer suggested by the promoters. [less ▲]

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See detailTremblement essentiel: diagnostic différentiel et traitement
DELVAUX, Valérie ULg; MAERTENS DE NOORDHOUT, Alain ULg

in Médecine et Hygiène (2001), 59

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See detailFaut-il corriger les stenoses de l'artere femorale superficielle chez le patient claudicant?
VAN DAMME, Hendrik ULg; Quaniers, Janine ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2001), 56(9), 639-49

Infrainguinal arterial occlusive disease is very common at the age of 60 years or older. It remains often asymptomatic. In one third of cases, it results in claudication. Claudication is a benign symptom ... [more ▼]

Infrainguinal arterial occlusive disease is very common at the age of 60 years or older. It remains often asymptomatic. In one third of cases, it results in claudication. Claudication is a benign symptom that rarely necessitates surgery or endovascular intervention. Physical training and control of risk factors are sufficient in most cases to improve the walking performance. Nowadays, the authors do no longer perform femoropopliteal bypass grafting as a first choice treatment for intermittent claudication. Conservative treatment has gained widespread acceptance for infrainguinal atherosclerosis with moderate ischemia. What is the fate of the claudicant? How effective is exercise therapy? Should we broaden the indications for percutaneous angioplasty? What is the place of femoropopliteal bypass graft for claudication? The authors investigate these different questions by means of an extensive review of recent literature. Based on this review and on international consensus documents, they justify their conservative approach to claudication secondary to occlusive disease of the superficial femoral artery. [less ▲]

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See detailOne-dimensional modelling of the plankton ecosystem of the north-western Corsican coastal area in relation to meteorological constraints
Skliris, Nikos; Elkalay, Khalid; Goffart, Anne ULg et al

in Journal of Marine Systems (2001), 27

In order to study the influence of wind mixing on the spring variability of the plankton production of the north western Corsican coastal area, a one-dimensional (1D), vertical, coupled hydrodynamic ... [more ▼]

In order to study the influence of wind mixing on the spring variability of the plankton production of the north western Corsican coastal area, a one-dimensional (1D), vertical, coupled hydrodynamic / biological model (ECOHYDROMV) is used. A hydrodynamic 1D model of the water column with a k–l turbulent closure is applied. The biological model comprises six state variables, representing the plankton ecosystem in the spring period: phytoplankton, copepods, nitrate, ammonium, particulate organic matter of phytoplanktonic origin and particulate organic matter of zooplanktonic origin. The system is influenced by turbulence (expressed by the vertical eddy diffusivity), temperature and irradiance. The model takes into account momentum and heat surface fluxes computed from meteorological data in order to simulate a typical spring atmospheric forcing for the considered area. Results show that primary production vertical structure is characterised by a subsurface maximum which deepens with time and is regulated by the opposite gradients of nitrate concentration and irradiance. Surface plankton productivity is mainly controlled by turbulent vertical transport of nutrients into the mixed layer. The short time scale variability of turbulent mixing generated by the wind appears to be responsible for the plurimodal shape of plankton blooms, observed in the considered area. Furthermore, the model is applied to the study of the spring evolution of the plankton communities off the bay of Calvi (Corsica) for the years 1986 and 1988. In order to initiate and validate the model, time series of hydrological, chemical and biological data have been used. The model reproduces accurately the spring evolution of the phytoplankton biomass measured in situ and illustrates that its strong variability in those years was in close relation to the variability of the wind intensity. [less ▲]

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See detailLe kimbanguisme : un millénarisme dynamique de la terre aux Cieux
Melice, Anne ULg

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2001), 47 (suppl.)

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See detailHommage à M.D. Grmek
Marganne, Marie-Hélène ULg

in Histoire des Sciences Médicales (2001), 35(4), 345-346

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See detailLa protection et la gestion du patrimoine biologique
Dufrêne, Marc ULg

in Bulletin de la Commission royale des Monuments, Sites et Fouilles (2001), 17

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See detailIn vitro tubulogenesis of endothelial cells by relaxation of the coupling extracellular matrix-cytoskeleton.
Deroanne, Christophe ULg; Lapiere, C. M.; Nusgens, Betty ULg

in Cardiovascular Research (2001), 49(3), 647-58

OBJECTIVE: This investigation aimed at determining the importance of the rigidity of the adhesive support and the participation of the cytoskeleton in tubulogenesis of endothelial cells in vitro. METHODS ... [more ▼]

OBJECTIVE: This investigation aimed at determining the importance of the rigidity of the adhesive support and the participation of the cytoskeleton in tubulogenesis of endothelial cells in vitro. METHODS: The morphotype, biosynthetic phenotype and cytoskeleton organization of human umbilical vein endothelial cells (HUVEC) were analyzed on supports of variable mechanical resistance. RESULTS: Western blot analysis revealed a strong reduction of the expression of actin and focal-adhesion plaque (FAP) proteins in HUVEC organized in tube-like structures (TLS) on soft matrigel or on matrigel co-polymerized with heat-denatured collagen as compared to HUVEC remaining in a monolayer pattern on rigid matrigel-coat or on matrigel co-polymerized with type I collagen. Human skin fibroblasts morphotype was not altered in these culture conditions and the pattern of FAP proteins and actin was not modulated. By using polyacrylamide gels polymerized with various concentrations of bis-acrylamide to modulate the mechanical resistance of the support and cross-linked to a constant amount of gelatin to provide an equal density of attachment sites, it was shown that the less rigid the support, the more endothelial cells switched to a tube-like pattern. Collagen type I-induced tubulogenesis was accompanied by a profound and reversible remodeling of the actin-FAP complex suggesting a weakening of the bridging between extracellular matrix (ECM) and the cytoskeleton. Human skin fibroblasts and smooth muscle cells, used as control cells, adhered strongly to the collagen, did not form TLS and their network of actin stress fibers was not remodeled. The inhibition of collagen type I-induced tubulogenesis by agents altering the actin cytoskeleton-FAP complex including calpain type I inhibitor, orthovanadate, KT5720 and jasplakinolide, further supports the determinant role of mechanical coupling between the cells and the matrix in tubulogenesis. CONCLUSIONS: A reduced tension between the endothelial cells and the extracellular matrix, originating in the support or within the cells is sufficient to trigger an intracellular signaling cascade leading to tubulogenesis, an event mimicking one of the last steps of angiogenesis. [less ▲]

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See detailSynthesis of large pore disordered MSU-type mesoporous silicas through the assembly of C16(EO)10 surfactant and TMOS silica source: Effect of the hydrothermal treatment and thermal stability of materials
Blin, J. L.; Léonard, Alexandre ULg; Su, B. L.

in Journal of Physical Chemistry B (2001), 105(26), 6070-6079

Decaoxyethylene cetyl ether [C 16(EO) 10] has been employed as templating agent for large pore disordered MSU-type mesoporous silicas synthesis. The effect of the hydrothermal treatment (heating time and ... [more ▼]

Decaoxyethylene cetyl ether [C 16(EO) 10] has been employed as templating agent for large pore disordered MSU-type mesoporous silicas synthesis. The effect of the hydrothermal treatment (heating time and temperature) on the textural properties, in particular, pore diameter of materials has been investigated. The obtained materials have been characterized by different techniques such as X-ray diffraction, scanning and transmission electron microscopy and nitrogen adsorption-desorption analysis. The thermal stability of the compounds is also evaluated. Our results show that the pore diameter depends strongly on the heating time and temperature. This is the result of a competition between the stretching of the surfactant chains, which can lead to the breakdown of the walls separating adjacent pores, and the reorganization of micelles with heating time and temperature. At higher temperature or for longer durations, a more extended surfactant molecular conformation can be obtained, which leads to materials with larger pore sizes. A reorganization of the micellar solution during the hydrothermal treatment in autoclave can also simultaneously occur to give materials with smaller pore diameter. It is found that compounds prepared with the nonionic surfactant exhibit an enhanced thermal stability compared to those synthesized with cetyltrimethylammonium bromide (CTMABr) as templating agent. This higher stability is related to the synthesis pathway and the structure of materials. [less ▲]

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See detailEfficacite d'une technique standardisee de MRCP pour la detection de choledocholithiase: experience d'un an chez des sujets symptomatiques.
Brisbois, D.; Plomteux, O.; NCHIMI LONGANG, Alain ULg et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2001), 84(6), 258-61

In our institution, MRCP is actually replacing diagnostic ERCP. This study is addressing its accuracy in the diagnosis of symptomatic choledocholithiasis. 137 MRCP were performed in patients with upper ... [more ▼]

In our institution, MRCP is actually replacing diagnostic ERCP. This study is addressing its accuracy in the diagnosis of symptomatic choledocholithiasis. 137 MRCP were performed in patients with upper abdominal pain and biological anomalies (n = 48), pain with cholelithiasis at sonography (n = 69) or non-alcoholic acute pancreatitis (n = 20) on a 1.5 T system with high gradients using a standardized combination of breath-hold HASTE and RARE sequences. We included in our study 74 patients who underwent as second test ERCP (n = 36), peroperative cholangiography (n = 13), or extensive follow-up with laboratory tests and/or sonography (n = 25). All examinations were judged as diagnostic, discrepancies between direct cholangiography and MRCP being noted in 4 patients (5.4%). Lithiasis was misinterpreted on MRCP as bubbles in 2 patients after sphincterotomy or surgery. We had two false positive diagnoses on MRCP: in one patient peroperative cholangiography was negative and in the other one ERCP was negative. With a sensitivity and PPV of 92%, a specificity and NPV of 96% MRCP in our experience is shown as an accurate diagnostic tool for the detection of stone in the common bile duct replacing ERCP. [less ▲]

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See detailMorpho-anatomy of the otic region in carapid fishes : eco-morphological study of their otoliths
Parmentier, Eric ULg; Vandewalle, Pierre ULg; Lagardère, Françoise

in Journal of Fish Biology (2001), 58

Carapid species are characterized by so-called otophysical structures (sonic muscles, broad first apophyses covering the anterior part of the swimbladder, etc.) The family includes pelagic (Pyramodon and ... [more ▼]

Carapid species are characterized by so-called otophysical structures (sonic muscles, broad first apophyses covering the anterior part of the swimbladder, etc.) The family includes pelagic (Pyramodon and Snyderidia) and benthic (Echiodon) species and ones that are either commensal with (Onuxodon, Carapus) or parasites of (Encheliophis) invertebrates (sea cucumbers, etc). The aim of the present work was to seek possible relationships between the structures of the inner ear (particularly the sagitta) on the one hand and otophysical structures and lifestyles within the Carapidae family. In the eight species studied, the otic cavity is wide, the saccular otosac and its sagitta are particularly developed. The sacculi touch each other on the median line. A comparison of the inner ear structures reveals notably that the species with the most developed sagitta and sacculus are those with the largest parapophyses and have a commensal or parasitic lifestyle. [less ▲]

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See detailEvolution of ventriculo-arterial coupling during acute myocardial ischemia
Kolh, Philippe ULg; D'Orio, Vincenzo ULg; LAMBERMONT, Bernard ULg et al

in European Heart Journal (2001), 22

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See detailThe anatomical distribution of radiological abnormalities in Kashin-Beck disease in Tibet
Hinsenkamp, Maurice; Ryppens, F.; Mathieu, F. et al

in International Orthopaedics (2001), 25

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See detailLe médicament parmi les thérapies relationnelles : Enquête et réflexions.
David, Claire; WAUTHY, Jacques ULg; Vaulet, Véronique et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2001)

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See detailWHO Collaborating Centre consensus meeting on anti-cytokine therapy in rheumatoid arthritis
Emery, P.; Reginster, Jean-Yves ULg; Appelboom, T. et al

in Rheumatology (2001), 40(6), 699-702

Severe adult rheumatoid arthritis is a cause of progressive disability and increased mortality across Europe. A cure for the disease remains elusive, but control of symptoms and maintenance of individual ... [more ▼]

Severe adult rheumatoid arthritis is a cause of progressive disability and increased mortality across Europe. A cure for the disease remains elusive, but control of symptoms and maintenance of individual independence is possible. Anti-cytokine therapies offer a new approach to disease management. They are effective after the failure of full doses of methotrexate, and are at least as effective as methotrexate in retarding the progression of radiological changes. Until more is known about the long-term safety and efficacy of these drugs they should be reserved for patients with severe disease who are progressing despite adequate doses of methotrexate or other disease-modifying anti-rheumatic drugs. They should be continued until therapeutic failure or intolerance. A comprehensive health economic evaluation is needed to optimally direct the use of these drugs. This should be undertaken when long-term safety and efficacy studies are completed. [less ▲]

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See detailLa sensibilisation du personnel dans le cadre de la mise en place d'un système de management environnemental : une porte d'entrée pour l'éducation relative à l'environnement dans l'entreprise ?
Domasik, Marie-Claire ULg; Semal, Nathalie ULg; Von Frenckell, Marianne ULg

in Education relative à l'environnement- Regards, recherches, réflexions (2001), 3

The increasing needs of enterprises in environmental training, in relation with the rise in environmental management systems in Belgium, generate new research needs in environmental education (EE) scope ... [more ▼]

The increasing needs of enterprises in environmental training, in relation with the rise in environmental management systems in Belgium, generate new research needs in environmental education (EE) scope. The authors experience shows that the entreprises’ expectations can meet EE objectives, and that environmental awareness programs for corporate employees can enable them to adapt their professionnal and private behaviour. This efficiency is based on interactive designing of training actions, responsability sharing and mutual learning. However, EE efficiency in enterprises depends on corporate culture and its capacity to evolve. [less ▲]

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See detailClinical and economic impact of diabetes mellitus on percutaneous and surgical treatment of multivessel coronary disease patients: insights from the Arterial Revascularization Therapy Study (ARTS) trial.
Abizaid, A.; Costa, M. A.; Centemero, M. et al

in Circulation (2001), 104(5), 533-8

BACKGROUND: Our aims were to compare coronary artery bypass grafting (CABG) and stenting for the treatment of diabetic patients with multivessel coronary disease enrolled in the Arterial Revascularization ... [more ▼]

BACKGROUND: Our aims were to compare coronary artery bypass grafting (CABG) and stenting for the treatment of diabetic patients with multivessel coronary disease enrolled in the Arterial Revascularization Therapy Study (ARTS) trial and to determine the costs of these 2 treatment strategies. METHODS AND RESULTS: Patients (n=1205) were randomly assigned to stent implantation (n=600; diabetic, 112) or CABG (n=605; diabetic, 96). Costs per patient were calculated as the product of each patient's use of resources and the corresponding unit costs. Baseline characteristics were similar between the groups. At 1 year, diabetic patients treated with stenting had the lowest event-free survival rate (63.4%) because of a higher incidence of repeat revascularization compared with both diabetic patients treated with CABG (84.4%, P<0.001) and nondiabetic patients treated with stents (76.2%, P=0.04). Conversely, diabetic and nondiabetic patients experienced similar 1-year event-free survival rates when treated with CABG (84.4% and 88.4%). The total 1-year costs for stenting and CABG in diabetic patients were $12 855 and $16 585 (P<0.001) and in the nondiabetic groups, $10 164 for stenting and $13 082 for surgery. CONCLUSIONS: Multivessel diabetic patients treated with stenting had a worse 1-year outcome than patients assigned to CABG or nondiabetics treated with stenting. The strategy of stenting was less costly than CABG, however, regardless of diabetic status. [less ▲]

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See detailHair loss after terbinafine treatment
Richert, Bertrand ULg; Uhoda, I.; de LA BRASSINNE, Michel ULg

in British Journal of Dermatology (2001), 145

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See detailPincer Nails: Definition and Surgical Treatment
Baran, R.; Hanecke, E.; Richert, Bertrand ULg

in Dermatologic Surgery (2001), 27

BACKGROUNG: There are four main types of ingrown nail. These are distal nail embedding, juvenile (subcutaneous) ingrown nail, hypertrophy of the lateral nail fold (lip), and pincer nail. OBJECTIVE: The ... [more ▼]

BACKGROUNG: There are four main types of ingrown nail. These are distal nail embedding, juvenile (subcutaneous) ingrown nail, hypertrophy of the lateral nail fold (lip), and pincer nail. OBJECTIVE: The etiology of pincer nail may be hereditary or acquired. The mechanism of the most common form, an enlarged base of the distal bony phalanx, is discussed. METHODS: Use of roentgenogram and magnetic resonance imaging highlights exophytes of the base and dorsal hyperostosis of the distal phalanx. RESULTS: Global assessment may lead in mild cases to medical therapy. Usually, however, the lateral matrix horn must be surgically removed or cauterized by phenol. Dermal grafting under the nail matrix provides excellent long-term results. [less ▲]

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See detailMechanisms for tolerance to diatomaceous earth between strains of Tribolium castaneum
Rigaux, Marylin; Haubruge, Eric ULg; Fields, Paul

in Entomologia Experimentalis et Applicata (2001), 101

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See detailNucleon nucleon scattering in a chiral constituent quark model
Bartz, Daniel ULg; Stancu, Floarea ULg

in Physical Review. C : Nuclear Physics (2001), C63

We study the nucleon-nucleon interaction in a chiral constituent quark model by using the resonating group method, convenient for treating the interaction between composite particles. The calculated phase ... [more ▼]

We study the nucleon-nucleon interaction in a chiral constituent quark model by using the resonating group method, convenient for treating the interaction between composite particles. The calculated phase shifts for the $^3S_1$ and $^1S_0$ channels show the presence of a strong repulsive core due to the combined effect of the quark interchange and the spin-flavour structure of the effective quark-quark interaction. Such a symmetry structure stems from the pseudoscalar meson exchange between the quarks and is a consequence of the spontaneous breaking of the chiral symmetry. We perform single and coupled channel calculations and show the role of coupling of the $\Delta\Delta$ and hidden color $CC$ channels on the behaviour of the phase shifts. [less ▲]

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See detailA twinned monoclinic crystal form of human peroxiredoxin 5 with eight molecules in the asymmetric unit
Declercq, Jean-Paul; Evrard, Christine ULg

in Acta Crystallographica Section D-Biological Crystallography (2001), D57

The monoclinic crystal form of human peroxiredoxin 5 with eight molecules in the asymmetric unit was obtained under exactly the same conditions as the tetragonal form with one molecule in the asymmetric ... [more ▼]

The monoclinic crystal form of human peroxiredoxin 5 with eight molecules in the asymmetric unit was obtained under exactly the same conditions as the tetragonal form with one molecule in the asymmetric unit, except that the latter was briefly cryosoaked with halide for derivatization. A merohedral twinning was observed, which is rather unusual in the monoclinic system and only possible with particular unit-cell dimensions. After detwinning the native and a mercury derivative, the structure was solved by the SIR method with the help of the non-crystallographic symmetry. The packing of the monoclinic and tetragonal forms are compared, with special attention to the role of bromide ions in the change of space group after crystallization. The availability of nine (eight monoclinic plus one tetragonal) independent molecules allows an analysis of the mobility. The two Cys residues implicated in the peroxide-reduction mechanism are located in rigid regions but are covered by mobile loops. [less ▲]

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See detailHistologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells.
Debiec-Rychter, M.; Van Valckenborgh, I.; Van den Broeck, C. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2001), 81(9), 1289-97

Pleomorphic adenoma gene 1 (PLAG1), a zinc finger transcription factor gene, is consistently rearranged and overexpressed in human pleomorphic adenomas of the salivary glands with 8q12 translocations. In ... [more ▼]

Pleomorphic adenoma gene 1 (PLAG1), a zinc finger transcription factor gene, is consistently rearranged and overexpressed in human pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we describe the immunohistochemical localization of PLAG1 protein in pleomorphic adenomas of the salivary gland and corresponding normal tissue, in relation to cytokeratin, vimentin, and BCL-2 expression. Normal salivary gland tissue was not immunoreactive for PLAG1. In primary pleomorphic adenomas, cells strongly immunoreactive for PLAG1 were detected in the outer layer of tubulo-ductal structures, which are thought to be the origin of cells with bi-directional, epithelial, and mesenchymal phenotypes. In contrast, epithelial cells with abundant cytokeratin in the inner tubulo-ductal structures only sporadically expressed PLAG1. BCL-2 immunoreactivity was found mainly in the cells surrounding the tubulo-ductal structures and in the solid undifferentiated cellular masses, within the areas that had moderate PLAG1 immunoreactivity. The variability of PLAG1 expression in neoplastic cells seemed to reflect the morphologic heterogeneity that correlated with the stage of differentiation of the tumor cells. Immunohistochemical/cytogenetic evaluation of two pleomorphic adenomas with t(3;8)(p21;q12) or t(5;8)(p13;q12) translocations demonstrated the clonal nature of immunophenotypically diverse cells. This finding confirms the theory that pleomorphic adenoma cells share a common single-cell origin, most likely from the epithelial progenitor basal duct cells. [less ▲]

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See detailSpatial distribution of foraging in female Antarctic fur seals Actocephalus gazella in relation to oceanographic variables : a scale dependent approach using geographical information system
Guinet, Christophe; Dubroca, Laurent; Lea, Mary Anne et al

in Marine Ecology. Progress Series (2001), 219

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See detailThe influence of stent length on clinical and angiographic outcome in patients undergoing elective stenting for native coronary artery lesions; final results of the Magic 5L Study.
Foley, D. P.; Pieper, M.; Wijns, W. et al

in European heart journal (2001), 22(17), 1585-93

AIMS: To prospectively evaluate the influence of stent length on 6 month clinical and angiographic outcome, in patients with native coronary lesions up to 45 mm in length, undergoing elective Magic ... [more ▼]

AIMS: To prospectively evaluate the influence of stent length on 6 month clinical and angiographic outcome, in patients with native coronary lesions up to 45 mm in length, undergoing elective Magic Wallstent implantation. METHODS AND RESULTS: On the basis of pre-procedural angiography, 276 patients (aged 61.3+/-10.2 years; 78.6% male; 41.7% unstable angina) with a total of 302 lesions were prospectively assigned to one of five different length categories of Magic Wallstent. Angiography in multiple matched projections before and after implantation and at 6 months follow-up was analysed at the core laboratory. Primary end-points for the efficacy analysis were cumulative incidence of major adverse cardiac events and quantitative coronary angiography analysis 6 months after stent implantation. Magic Wallstent implantation was successful in 301 of 302 lesions and in 98.6% a residual stenosis <20% by online quantitative coronary angiography was achieved. At 30 days, 6.2% (1.8% subacute occlusion) of patients had experienced major adverse cardiac events, 27.5% at 6 months and 30.4% at 9 months. Angiographic restenosis occurred in 37%. Restenosis rates for the mini, extra-short, short, medium and long Wallstent groups were 25.9%, 25%, 22.6%, 36.2% and 67.5%, respectively. Multivariate analysis revealed stent length to be independently associated with greater angiographic restenosis and major adverse cardiac events. CONCLUSIONS: While shorter Magic Wallstents provided late outcomes comparable with short balloon-expandable stents, excessive restenosis with longer Wallstents should obviate their use in elective percutaneous intervention. Long coronary lesions provide a challenging substrate for emerging antirestenosis therapies, such as stent coatings and brachytherapy. [less ▲]

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See detailImportance of post-transcriptional regulation of chemokine genes by oxidative stress.
JOSSE, Claire ULg; Boelaert, J. R.; Best-Belpomme, M. et al

in Biochemical Journal (2001), 360(Pt 2), 321-33

The transcription factor, nuclear factor kappa B (NF-kappa B), is activated by various stimuli including cytokines, radiation, viruses and oxidative stress. Here we show that, although induction with H(2 ... [more ▼]

The transcription factor, nuclear factor kappa B (NF-kappa B), is activated by various stimuli including cytokines, radiation, viruses and oxidative stress. Here we show that, although induction with H(2)O(2) gives rise to NF-kappa B nuclear translocation in both lymphocyte (CEM) and monocyte (U937) cells, it leads only to the production of mRNA species encoding interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha in U937 cells. Under similar conditions these mRNA species are not observed in CEM cells. With the use of a transient transfection assay of U937 cells transfected with reporter constructs of the IL-8 promoter and subsequently treated with H(2)O(2), we show that (1) IL-8-promoter-driven transcription is stimulated in both U937 and CEM cells and (2) the NF-kappa B site is crucial for activation because its deletion abolishes activation by H(2)O(2). The production of IL-8 mRNA in U937 cells is inhibited by the NF-kappa B inhibitors clasto-lactacystin-beta-lactone and E-64D (l-3-trans-ethoxycarbonyloxirane-2-carbonyl-L-leucine-3-methyl amide) but requires protein synthesis de novo. Moreover, inhibition of the p38 mitogen-activated protein kinase also decreases the IL-8 mRNA up-regulation mediated by H(2)O(2). Taken together, these results show the importance of post-transcriptional events controlled by a p38-dependent pathway in the production of IL-8 mRNA in U937. The much lower activation of p38 in CEM cells in response to H(2)O(2) could explain the lack of stabilization of IL-8 mRNA in these cells. [less ▲]

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See detailIntermittent Cyclic Tiludronate in the Treatment of Osteoporosis
Reginster, Jean-Yves ULg; Christiansen, C.; Roux, C. et al

in Osteoporosis International (2001), 12(3), 169-77

The objective of the study was to determine the efficacy and safety of tiludronate in the treatment of postmenopausal osteoporosis. Two placebo-controlled, randomized, double-masked, multicenter, cyclical ... [more ▼]

The objective of the study was to determine the efficacy and safety of tiludronate in the treatment of postmenopausal osteoporosis. Two placebo-controlled, randomized, double-masked, multicenter, cyclical, intermittent, dose-ranging studies including 1805 women with low vertebral bone mineral density and prevalent vertebral fractures and 488 women with low bone mineral density and no prevalent fracture were conducted. Patients were randomized to either tiludronate 50 mg/day, tiludronate 200 mg/day or placebo, given orally for the first 7 days of each month. A supplement of 500 mg elemental calcium was provided daily from day 8 to the end of the month. Both studies demonstrated no statistically or clinically relevant trends in the incidence of adverse effects across the three treatment groups. However, tiludronate administered at these two doses in a cyclic intermittent regimen was not effective in reducing the incidence of vertebral fractures or increasing spinal bone mineral density. Thus, tiludronate, administered at these doses in a cyclic intermittent regimen, cannot be considered an appropriate treatment of postmenopausal osteoporosis, notwithstanding a high safety profile. [less ▲]

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