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See detailInfluence of calving season on the interactions among reproductive disorders of dairy cows.
Labernia, J.; Lopez-Gatius, F.; Santolaria, P. et al

in Animal Science Journal (1998), 67

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See detailPrediction of response to treatment with recombinant human erythropoietin in anaemia associated with cancer.
Beguin, Yves ULg

in Medical Oncology (Northwood, London, England) (1998), 15 Suppl 1

The anaemia associated with cancer can be effectively treated with recombinant human erythropoietin (rHuEpo) in about 60% of the patients. However, the response rate varies according to treatment ... [more ▼]

The anaemia associated with cancer can be effectively treated with recombinant human erythropoietin (rHuEpo) in about 60% of the patients. However, the response rate varies according to treatment modalities as well as the response criteria used. A number of disease- or chemotherapy-related factors determines the probability of response. Several specific mechanisms of anaemia, such as haemolysis, splenomegaly, bleeding, haemodilution, or ineffective erythropoiesis can seriously interfere with response. However, the type of tumor, in particular haematologic versus non-haematologic, is not critical, except in situations of major marrow involvement and limited residual haematopoiesis. Stem cell damage by previous therapy, reflected by low platelet counts or high transfusion needs, will impair response. In addition, marrow suppression by current intensive chemotherapy will also have a negative impact. Besides its intensity, the type of chemotherapy may not be critical, although patients undergoing platinum-based chemotherapy may respond faster than those receiving non-platinum regimens. Complications such as infections, bleeding or nutritional deficiencies may have a major negative impact on outcome. An important response-limiting factor is functional iron deficiency, i.e. an imbalance between iron needs in the erythropoietic marrow and iron supply, which depends on the level of iron stores and its rate of mobilisation. Therefore, oral or preferably intravenous iron supplements should be given when serum ferritin is below 40-100 micrograms/l, reflecting the absence of iron stores, or when the percentage of hypochromic red cells rises above 10%, indicating functional iron deficiency even in the presence of adequate storage iron. Because up to 40% of the patients will not respond to rHuEpo, it is of utmost importance to develop models that could help predict response to rHuEpo and thus select the most appropriate cancer patients for this therapy. Most studies of patients with myeloma or lymphoma have indicated that patients with a low baseline serum Epo level will respond better, but this is not true of patients with solid tumors. Also of considerable interest are early changes of erythropoietic parameters after 2 to 4 weeks of treatment, including increments of serum transferrin receptor (sTfR), reticulocytes and haemoglobin, as well as the persistence of elevated ferritin or Epo levels. Combination of baseline serum Epo and the 2-week increment of sTfR or haemoglobin may provide the best prediction of response. [less ▲]

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See detailPurification of myeloperoxidase from equine polymorphonuclear leucocytes.
Mathy, Marianne ULg; Bourgeois, E.; Grulke, Sigrid ULg et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1998), 62(2), 127-32

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute ... [more ▼]

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute inflammation). To develop an assay for measurement of plasma MPO in horses during the above-mentioned infectious and inflammatory conditions, MPO was purified from equine PMN isolated from blood anticoagulated with citrate. PMN were extracted in a saline milieu (0.2 M Na acetate, 1 M NaCl, pH 4.7) to eliminate most of cellular proteins. Pellets were then extracted in the same buffer containing cationic detergent (1% cetyltrimethyl ammonium bromide). The supernatant was further purified by ion exchange chromatography (Hiload S Sepharose HP column 0.5 x 26 cm, equilibrated with 25 mM Na acetate, 0.2 M NaCl, pH 4.7) with a NaCl gradient (until 1 M). Most of the peroxidase activity of MPO (spectrophotometrically measured by the oxidation of orthodianisidine by hydrogen peroxide) was eluted at 0.65 M NaCl. MPO was further purified by gel filtration chromatography (Sephacryl S 200 column 2.6 x 42 cm with 25 mM Na acetate, 0.2 M NaCl, pH 4.7). MPO (specific activity: 74.3 U/mg) was obtained with a yield of 30% from the detergent extraction supernatant. Electrophoresis (non-reducing conditions) showed 3 bands identified, by comparison with human MPO, (i) the mature tetrameric enzyme (150 kDa) with 2 light and 2 heavy subunits, (ii) the precursor form (88 kDa) and (iii) a form of the heavy subunit without the prosthetic heme group (40 kDa). The mature enzyme and its precursor were glycosylated and possessed peroxidase activity. Equine MPO showed strong similarities with human and bovine MPO, with an absorption peak at 430 nm (Soret peak) characteristic of ferrimyeloperoxidase. Enzymatic activity was pH dependent (optimal value at pH 5.5). [less ▲]

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See detailImmigrés et minorités ethniques dans l'espace politique européen
Martiniello, Marco ULg; Hily, M.-A.

in Revue Européenne des Migrations Internationales (1998), 14(2),

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See detailLe cas clinique du mois Un homme a caryotype 46,XX.
Marquet, F.; Verloes, Alain ULg; Beckers, Albert ULg

in Revue Médicale de Liège (1998), 53(9), 515-517

The XX males represent a rare expression of the Klinefelter syndrome associated with hypergonadotropic hypogonadism. Generally the patients are of small stature with normal secondary sexual male features ... [more ▼]

The XX males represent a rare expression of the Klinefelter syndrome associated with hypergonadotropic hypogonadism. Generally the patients are of small stature with normal secondary sexual male features but with small testes and constant sterility. The plasma concentrations of FSH and LH are very high in accordance with the decrease of the testicular function. From the genetic point of view, the XX males may be divided in 3 groups: 1) in 80% of cases, the XX males bear the SRY gene and exhibit a XY translation during the paternal meiosis with the presence of the SRY gene on one of the X chromosomes as a marker of the male differentiation; 2) in 10% of cases, the males are (SRY-)XX; the abnormal development is then due to other genes than the TDF, which, when mutated, can induce sexual male differentiation. The remaining 10% of cases are due to chromosomal mosaicism with more XX than XY. [less ▲]

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See detailChorologie et écologie de Pycnoporus Cinnabarinus (Polyporaceae) en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes
Thoen, Daniel ULg; Fraiture, A.; Nicolas, Jacques ULg

in Belgian Journal of Botany (1998), 131(2), 260-272

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de ... [more ▼]

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de distribution. La propagation du champignon semble s'être effectuée à deux "vitesses" : par bonds, sur des distances de plusieurs dizaines de kilomètres, et de proche en proche, au départ de populations voisines. L'analyse de la fréquence et de la fréquence cumulée des récoltes montre deux grandes "vagues" successives d'expansion du champignon. La liste des arbres hôtes est établie ainsi que la fréquence relative du champignon en fonction des hôtes. Les hôtes les plus fréquents sont les bouleaux (Betula alba et Betula pendula), le hêtre (Fagus sylvatica), le sorbier des oiseleurs (Sorbus aucuparia) et les chênes (Quercus robur et Quercus petraea). Les causes de l'extension et des fluctuations des populations du champignon ne sont pas connues avec certitude. Il semble cependant que des facteurs climatiques et le fait que de plus grandes quantités de bois pourrissant soient abandonnées sur les coupes puissent être impliqués. [less ▲]

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See detailPharma clinics. Comment je traite ... un patient diabetique avec obesite severe.
Scheen, André ULg; Triches, K.; Luyckx, Françoise ULg et al

in Revue Médicale de Liège (1998), 53(7), 386-9

Obesity plays a crucial role in type 2 diabetes pathophysiology and a major weight loss markedly improves glycaemic control. The common failure of classical treatments leads to the use of more aggressive ... [more ▼]

Obesity plays a crucial role in type 2 diabetes pathophysiology and a major weight loss markedly improves glycaemic control. The common failure of classical treatments leads to the use of more aggressive weight-reduction approaches, such as very-low-calorie diets (VLCDs), anti-obesity drugs or even bariatric surgery. VLCDs are very successful in the short-term but rather disappointing in the long-term. Anti-obesity compounds only induce a modest mean weight reduction, even if some patients appear to be better responders. Interestingly, serotoninergic agents increase insulin sensitivity and glycaemic control, independently of weight loss. Bariatric surgery provides the most impressive results. In well-selected subjects, gastroplasty (either vertical ring gastroplasty or adjustable silicone gastric banding) generally induces a considerable weight loss which results in a remarkable and sustained glycaemic control improvement and allows the reduction, or even the suppression, of any antidiabetic treatment. This ultimate solution should not be neglected after failure of medical approaches, provided that the indication is correct, the surgical procedure is performed in a specialized centre and the followup is well organized by a multidisciplinary team. [less ▲]

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See detailImpairment of the mitochondrial electron chain transport prevents NF-kappa B activation by hydrogen peroxide.
Josse, C.; Legrand-Poels, S.; Piret, B. et al

in Free Radical Biology & Medicine (1998), 25(1), 104-112

A large body of work has been devoted to mechanisms leading to the activation of the transcription factor NF-kappa B in various cell types. Several studies have indicated that NF-kappa B activation by ... [more ▼]

A large body of work has been devoted to mechanisms leading to the activation of the transcription factor NF-kappa B in various cell types. Several studies have indicated that NF-kappa B activation by numerous stimuli depends on the intracellular generation of reactive oxygen species (ROS). In this report, we first demonstrated that inhibition of the electron transport chain by either rotenone or antimycine A gave rise to dose-dependent inhibition of NF-kappa B translocation induced by 150 microM of hydrogen peroxide (H2O2). Conversely, the impairment of the mitochondrial respiratory chain did not affect T lymphocyte treatment by TNF-alpha (tumor necrosis factor alpha) or pre-B lymphocyte treatment with LPS (lipopolysaccharide). We also showed that oligomycine which inhibits ATP synthase and FCCP, which uncouples respiration also led to dose-dependent inhibition of NF-kappa B activation by H2O2. All these inhibitors were also shown to inhibit mitochondrial respiration in lymphocytes assessed by oxygen consumption. Although only a transient drop in ATP concentration was observed when lymphocytes were treated by H2O2, this effect was remarkably reinforced in the presence of oligomycine demonstrating the crucial role of ATP in the signal transduction pathway induced by H2O2. [less ▲]

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See detailCompte-rendu de l'article de Paul Wathelet, Rhésos ou la quête de l'immortalité
Renaud, Jean-Michel ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1998), Supplément 6

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See detailUne préparation multimédias à affronter les conflits professeur-élèves en classe
Leclercq, Dieudonné ULg; Rommes, O.; Georges, François ULg et al

in Education-Formation (1998), 36130

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See detailThe C-terminal helix of human apolipoprotein AII promotes the fusion of unilamellar liposomes and displaces apolipoprotein AI from high-density lipoproteins.
Lambert, Géraldine ULg; Decout, A.; Vanloo, B. et al

in European Journal of Biochemistry (1998), 253(1), 328-38

To assess the functional properties of apolipoprotein (apo) AII and to investigate the mechanism leading to the displacement of apo AI from native and reconstituted high-density lipoproteins (HDL and r ... [more ▼]

To assess the functional properties of apolipoprotein (apo) AII and to investigate the mechanism leading to the displacement of apo AI from native and reconstituted high-density lipoproteins (HDL and r-HDL) by apo AII, wild-type and variant apo AII peptides were synthesized. The wild-type peptides, residues 53-70 and 58-70, correspond to the C-terminal helix of apo AII and are predicted to insert at a tilted angle into a lipid bilayer. We demonstrate that both the apo AII-(53-70) peptide, and to a lesser extent the apo AII-(58-70) peptide are able to induce fusion of unilamellar lipid vesicles together with membrane leakage, and to displace apo AI from HDL and r-HDL. Two variants of the apo AII-(53-70)-wild-type (WT) peptide, designed either to be parallel to the water/lipid interface [apo AII-(53-70)-0 degrees] or to retain an oblique orientation [apo AII-(53-70)-30 degrees], were synthesized in order to test the influence of the obliquity on their fusogenic properties and ability to displace apo AI from HDL. The parallel variant did not bind lipids, due to its self-association properties. However, the apo AII-(53-70)-30 degrees variant was fusogenic and promoted the displacement of apo AI from HDL. Moreover, the extent of fusion of the apo AII-(53-70)-WT, apo AII-(58-70)-WT and apo AII-(53-70)-30 degrees peptides was related to the alpha-helical content of the lipid-bound peptides measured by infrared spectroscopy. Infrared measurements using polarized light also confirmed the oblique orientation of the helical component of the three peptides. In native and r-HDL, the tilted insertion of the C-terminal helix of apo AII resulting in a partial destabilization of the HDL external lipid layer might contribute to the displacement of apo AI by apo AII. [less ▲]

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See detailInfluence de facteurs abiotiques ou biotiques sur l'evaluation de la sensibilite d'Aphidius rhopalosiphi De Stefani-Perez a la phosalone.
Guelton, O.; Deleu, R.; Schiffers, Bruno ULg et al

in Parasitica (1998), 54(2-3),

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des ... [more ▼]

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des céréales. L'influence de l'humidité relative, de la photo période, du mode de conservation des momies ainsi que du sexe des insectes sur la sensibilité des parasitoïdes à la phosalone a été étudiée. L'humidité relative influence le plus la sensibilité des insectes lors des essais, le mode de conservation des momies se révèle important lui aussi. [less ▲]

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See detailAbdominal aortic aneurysms in octogenarians.
VAN DAMME, Hendrik ULg; SakalihasanN, Natzi ULg; Vazquez, C. et al

in Acta Chirurgica Belgica (1998), 98(2), 76-84

The decision on whether to operate or not abdominal aortic aneurysms (AAA) in elderly depends on the relative risk of the operation versus the natural course of the unoperated AAA. From January 1984 to ... [more ▼]

The decision on whether to operate or not abdominal aortic aneurysms (AAA) in elderly depends on the relative risk of the operation versus the natural course of the unoperated AAA. From January 1984 to December 996, 138 patients, aged 80 years and older, were referred to our department for an aneurysm of 40 mm or more (transverse diameter) of the infrarenal abdominal aorta (95 asymptomatic, 15 painful, and 28 ruptured AAA). For 58 patients with asymptomatic AAA, operation was denied at referral because of transverse diameter less than 50 mm (n = 21), patient refusal (n = 10) or unacceptable operative risk or poor general condition (n = 27). Thirty-four of these observed AAA were ultimately operated after a mean delay of 41 months because of aneurysm enlargement (n = 15), aneurysm tenderness (n = 6) or rupture (n = 13). Overall, 52 patients had immediate (n = 37) or delayed (n = 15) elective repair of their AAA, with an in-hospital mortality of 5.7%. Urgent operation was done for 21 patients with a painful AAA. Six patients died at hospital (28% mortality rate). Emergent surgery was applied to 41 patients with ruptured AAA (including 13 AAA who ruptured during surveillance). The operative mortality in this subgroup attained 68%. Follow-up for the 77 survivors and the 24 non-operative patients averaged 43 months. The 5-year survival (operative mortality included) is 47% for electively operated patients, 30% for urgently and 20% for emergently operated patients. For comparison, the 5-year survival of an age and sex matched Belgian population is 63%. For the 24 medically followed AAA, the 5-year survival was 33%. In six cases, the cause of death was rupture of the AAA. Of the 58 patients for whom operation was initially not considered, 19 (33%) presented AAA rupture (13 operated in emergency and 6 who never came to surgery). The operative outcome of AAA repair in octogenarians is less favourable than in the younger age group (3.6% mortality after elective repair, 44% after operation for AAA rupture, according to our institution data). The authors conclude that AAA surgery should not be denied to octogenarians on the basis of advanced age alone. They recommend a straightforward surgery for otherwise healthy octogenarians with AAA of 50 mm diameter, surveillance up to 60 mm for high-risk patients and no surgery for unfit, bedridden or demented patients. [less ▲]

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See detailActualites therapeutiques 1997-1998 (1). Premiere partie.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(8), 459-66

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be stressed. This first part is devoted to drugs acting on cardiovascular, respiratory, digestive and neurologic diseases. [less ▲]

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See detailAn Efficient Sampling Technique Used to Detect Four Foodborne Pathogens on Pork and Beef Carcasses in Nine Belgian Abattoirs
Korsak Koulagenko, Nicolas ULg; Daube, Georges ULg; Ghafir, Yasmine et al

in Journal of Food Protection (1998), 61(5), 535-541

The method presented in this paper should prove useful in assessing the effectiveness of HACCP plans developed in slaughterhouses. Samples were collected by swabbing well-defined areas of pork and beef ... [more ▼]

The method presented in this paper should prove useful in assessing the effectiveness of HACCP plans developed in slaughterhouses. Samples were collected by swabbing well-defined areas of pork and beef carcasses with sterile gauze. Between 160 and 420 half-carcasses were swabbed in each of nine pork or beef slaughterhouses. Swabs from five carcasses were placed in the same sterile Stomacher bag, constituting a single composite sample. Standard or validated analytical methods were used to isolate and characterize four foodborne pathogens. Salmonella spp., Listeria monocytogenes, Campylobacter spp., and verocytotoxin-producing E. coli were detected, respectively, in 27, 2, 2, and 14% of the pork samples and 0, 22, 10, and 5% of the beef samples. Of the 10 samples positive for E. coli O157, only one yielded an isolate confirmed to be enterohemorrhagic. Since Salmonella spp. appear as the main contaminant port (27%) and L. monocytogenes as the main containment of beef (22%), any slaughterhouse sampling plan should include testing for the former in the case of pork carcasses and for the latter in the case of beef carcasses. One should also test regularly for the presence of E. coli O157 and Campylobacter spp. in pork and beef abattoirs. The method presented here is an easy way to assess the contamination rate of carcasses at the end of the slaughtering process. [less ▲]

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See detailBronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bone marrow transplantation.
Baron, Frédéric ULg; Hermanne, Jean-Philippe; Dowlati, A. et al

in Bone Marrow Transplantation (1998), 21(9), 951-4

A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT ... [more ▼]

A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT) from an HLA-matched brother who suffered from severe Crohn's disease. BOOP occurred 20 days after idiopathic interstitial pneumonia, in the context of severe ulcerative colitis. Lung and colon biopsies showed no signs of CMV infection or GVHD. The patient was treated with oral methylprednisolone 1 mg/kg/day and his clinical status and chest X-ray improved slowly. Remarkably, the symptoms of colitis also resolved with prednisone therapy and he is now symptom-free. We hypothesize that ulcerative colitis may have been transmitted from donor to recipient (adoptive autoimmunity) and that it was complicated by BOOP. However, other factors such as CMV may have contributed to the occurrence of BOOP. [less ▲]

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See detailLe cas clinique du mois. Une nephropathie galopante chez un patient diabetique de type 2.
Philips, Jean-Christophe ULg; Scheen, André ULg; Firre, E. et al

in Revue Médicale de Liège (1998), 53(4), 171-4

We report the case of a patient with insulin-requiring type 2 diabetes who exhibited a rapid deterioration of his renal function leading to haemodialysis in a few months. Various diagnosis were considered ... [more ▼]

We report the case of a patient with insulin-requiring type 2 diabetes who exhibited a rapid deterioration of his renal function leading to haemodialysis in a few months. Various diagnosis were considered to explain this rapid deterioration, excluding diabetic nephropathy as major etiology. The exploration, especially renal biopsy, demonstrated the presence of a glomerulonephritis due to the deposition of immune complexes associated to active hepatitis C rather than diabetic glomerulosclerosis. A treatment with interferon-alpha allowed to partially restore renal function, this recovery permitting the interruption of hemodialysis, with a current follow-up of more than 6 months. [less ▲]

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See detailContinuous and non-invasive study of brain oxygenation in the calf by near infrared spectroscopy
Pringle, John; Uystepruyst, C.; Art, Tatiana ULg et al

in Research in Veterinary Science (1998), 65

Near infrared spectroscopy (NIRS) was used to detect changes in brain oxygenation in five tranquilised calves that were placed on a hypoxic gas mixture (10 per cent O2/90 per cent N2) and hyperoxic gas ... [more ▼]

Near infrared spectroscopy (NIRS) was used to detect changes in brain oxygenation in five tranquilised calves that were placed on a hypoxic gas mixture (10 per cent O2/90 per cent N2) and hyperoxic gas mixture (30 per cent O2/70 per cent N2) for five minutes at each concentration. A NIRO 500 (Hamamatsu, Japan) was used for the NIRS, with the incident light source and separate detector (optodes) placed on shaved skin on the most dorsal surface of the frontal bone. Sequential arterial blood gas sample analyses provided confirmation of the appropriate change in systemic oxygenation status. By the end of the five-minute-period of breathing 10 per cent oxygen, NIRS of the calf head detected highly significant changes in haemoglobin oxygenation reflective of hypoxaemia, with oxyhaemoglobin decreasing by 23.5 units (P<0.01) and deoxyhaemoglobin increasing by 45.6 units, (P<0.01) from the baseline of breathing room air. Total haemoglobin (oxyhaemoglobin + deoxyhaemoglobin) showed a significant increase of 22.1 units (P<0.05) but there was no significant change in NIRS determined cytochrome aa3 oxygenation. Concomitant blood gas alterations included significant decreases in PaO2 (-27.8 mmHg, P<0.01), haemoglobin saturation (-29.0 per cent, P<0.05), and PaCO2 (-7.8 mmHg, P<0.05) and significantly increased blood pH (0.059, P<0.05). At the end of the five minutes of breathing 30 per cent oxygen NIRS of the calf head detected significantly increased oxyhaemoglobin (13.1 units, P<0.01) and decreased deoxyhaemoglobin (-13.7 units, P<0.05) when compared with baseline breathing of room aim. Total haemoglobin and cytochrome aa3 were unchanged from baseline. The accompanying arterial blood gas changes included significant increases in PaO2 (30.9 mmHg, P<0.05), arterial O2 saturation (11.7 per cent, P<0.05), and significantly decreased pH (-0.026, P<0.05). This study showed that NIRS can be used to continuously and non-invasively detect cerebral oxygenation changes in the live calf in response to both increased and decreased systemic arterial oxygen. Additionally, despite induction of profound hypoxaemia, cytochrome aa3 in the brain did not appear to become reduced. [less ▲]

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See detailReassessment of Viséan Miospore biostratigraphy in the Amazon basin, northern Brazil.
Loboziak, S; Melo, J.H.G.; Streel, Maurice ULg

in Review of Palaeobotany and Palynology (1998), 104

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See detailIsotopic constraints on the Cenozoic evolution of the carbon cycle
François, Louis ULg; Godderis, Y.

in Chemical Geology (1998), 145(3-4), 177-212

In the last few years, several models have been built to explore the Cenozoic evolution of the carbon and strontium cycles. Of particular interest is the study of the impact on the carbon cycle of major ... [more ▼]

In the last few years, several models have been built to explore the Cenozoic evolution of the carbon and strontium cycles. Of particular interest is the study of the impact on the carbon cycle of major mountain uplifts such as the Himalayan orogeny. To explain the Cenozoic increase in the measured seawater strontium isotopic ratio, it was recently proposed that the Himalyan uplift could be responsible for an enhanced consumption of atmospheric CO2 by continental silicate weathering. Here, a new model of the carbon cycle evolution over Cenozoic times is presented. It calculates the various fluxes involved in the organic and inorganic components of the carbon cycle from the seawater delta C-13, the biological isotopic fractionation in the ocean and the seafloor spreading rate. The model equilibrates the budgets of the carbon and alkalinity cycles on the million year timescale, assuming as many previous investigators that the system remains close to equilibrium. The validity of this equilibrium approximation is examined critically. Various sensitivity experiments are performed in order to test the impact of the model parameters on the results. The calculated history of the carbonate deposition rate is consistent with the available reconstruction. The continental silicate weathering rate calculated by the model appears to be widely insensitive to the model parameters, showing three distinct evolutions over the Cenozoic. The model indeed suggests a time of relative constancy of the silicate weathering flux before 40 Ma, followed by a period of slow decrease until 15 Ma and finally a marked increase up to the present. In a progressively cooler world, this evolution may be interpreted as a change from a 'chemically' controlled to a 'physically' controlled weathering regime. The evolution of continental silicate weathering thus partly appears decoupled from the increase in the observed seawater strontium isotopic ratio. For this reason, the evolution of the calculated riverine Sr-87/ Sr-86 ratio shows a strong increase over the Cenozoic, from about 0.710 to 0.712. However, this increase may largely be reduced by considering the recycling of a pelagic carbonate reservoir increasing over the Cenozoic or by assuming that seafloor basalt weathering is a CO2- or climate-dependent process. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMating system of Calluna vulgaris (L.) Hull : self-sterility and outcrossing estimations
Mahy, Grégory ULg; Jaqcuemart, Anne Laure

in Canadian Journal of Botany (1998), 76

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See detailThe origin of the alpha-domain intermediate in the folding of hen lysozyme
Matagne, André ULg; Chung, E. W.; Ball, L. J. et al

in Journal of Molecular Biology (1998), 277(5), 997-1005

Stopped-flow fluorescence and circular dichroism spectroscopy have been used in conjunction with quenched-flow hydrogen exchange labelling, monitored by electrospray ionization mass spectrometry, to ... [more ▼]

Stopped-flow fluorescence and circular dichroism spectroscopy have been used in conjunction with quenched-flow hydrogen exchange labelling, monitored by electrospray ionization mass spectrometry, to compare the refolding kinetics of hen egg-white lysozyme at 20 degrees C and 50 degrees C. At 50 degrees C there is clear evidence for distinct fast and slow refolding populations, as observed at 20 degrees C, although folding occurs significantly more rapidly. The folding process is, however, substantially more cooperative at the higher temperature. In particular, the transient intermediate on the major refolding pathway at 20 degrees C, having persistent native-like structure in the alpha-helical domain of the protein, is not detected by hydrogen exchange labelling at 50 degrees C. Ln addition, the characteristic maximum in negative ellipticity and the minimum in fluorescence intensity observed in far UV CD and intrinsic fluorescence experiments at 20 degrees C, respectively, are not seen at 50 degrees C. Addition of 2 M NaCl to the refolding buffer at 50 degrees C, however, regenerates both the hydrogen exchange and optical properties associated with the alpha-domain intermediate but has no significant effect on the overall refolding kinetics. Together with previous findings, these results indicate that non-native interactions within the alpha-domain intermediate are directly responsible for the unusual optical properties observed during refolding, and that this intermediate accumulates as a consequence of its intrinsic stability in a folding process where the formation of stable structure in the beta-domain constitutes the rate-limiting step for the majority of molecules. (C) 1998 Academic Press Limited. [less ▲]

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See detailDelayed-onset profound biotinidase deficiency.
Wolf, B.; Pomponio, R. J.; Norrgard, K. J. et al

in The Journal of pediatrics (1998), 132(2), 362-5

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb ... [more ▼]

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb weakness, spastic paresis, and eye problems, such as loss of visual acuity and scotomata, rather than the more characteristic symptoms observed in young untreated children with the disorder. These older children each have different mutations, but they are the same as those of children who have exhibited symptoms at an early age. Biotinidase deficiency should be considered in older children who suddenly experience limb weakness and/or spastic paresis and eye symptoms. [less ▲]

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See detailLinoleic acid-induced activity of plant uncoupling mitochondrial protein in purified tomato fruit mitochondria during resting, phosphorylating, and progressively uncoupled respiration.
Jarmuszkiewicz, W.; Almeida, A.; Sluse-goffart, C. et al

in Journal of Biological Chemistry (1998), 273(52), 34882-34886

An uncoupling protein was recently discovered in plant mitochondria and demonstrated to function similarly to the uncoupling protein of brown adipose tissue. In this work, green tomato fruit mitochondria ... [more ▼]

An uncoupling protein was recently discovered in plant mitochondria and demonstrated to function similarly to the uncoupling protein of brown adipose tissue. In this work, green tomato fruit mitochondria were purified on a self-generating Percoll gradient in the presence of 0.5% bovine serum albumin to deplete mitochondria of endogenous free fatty acids. The uncoupling protein activity was induced by the addition of linoleic acid during the resting state, and in the progressively uncoupled state, as well as during phosphorylating respiration in the presence of benzohydroxamic acid, an inhibitor of the alternative oxidase and with succinate (+ rotenone) as oxidizable substrate. Linoleic acid strongly stimulated the resting respiration in fatty acid-depleted mitochondria but had no effect on phosphorylating respiration, suggesting no activity of the uncoupling protein in this respiratory state. Progressive uncoupling of state 4 respiration decreased the stimulation by linoleic acid. The similar respiratory rates in phosphorylating and fully uncoupled respiration in the presence and absence of linoleic acid suggested that a rate-limiting step on the dehydrogenase side of the respiratory chain was responsible for the insensitivity of phosphorylating respiration to linoleic acid. Indeed, the ADP/O ratio determined by ADP/O pulse method was decreased by linoleic acid, indicating that uncoupling protein was active during phosphorylating respiration and was able to divert energy from oxidative phosphorylation. Moreover, the respiration rates appeared to be determined by membrane potential independently of the presence of linoleic acid, indicating that linoleic acid-induced stimulation of respiration is due to a pure protonophoric activity without any direct effect on the electron transport chain. [less ▲]

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See detailQuantitative palynology of latest Famennian events in the Sauerland.
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (1998), 15

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See detailDiagnostic des troubles fonctionnels et inflammatoires chroniques des petites voies aériennes
Art, Tatiana ULg; Amory, Hélène ULg; Duvivier, D. H. et al

in Pratique Vétérinaire Equine (1998), 30

Faced with the numerous respiratory dysfunctions, there is a large variety of investigation techniques. None is sufficient. Each has its specific application, its advantages and its drawbacks. Detection ... [more ▼]

Faced with the numerous respiratory dysfunctions, there is a large variety of investigation techniques. None is sufficient. Each has its specific application, its advantages and its drawbacks. Detection of disorders associated with inflammation of small air ways (bronchos¬pasm, pulmonary vasoconstriction, bronchial hyper-reactivity) is a first step. The field examinations Wow: arterial blood gases (which give a global appreciation of the pulmonary function), LTB and LBA (which may characterize the pathogenic agent), endoscopy and biop¬sy are the most useful. Then, a battery of tests is used, performed in a very specialized infrastructure : scanning, ventilation mechanics... which allow to evaluate the state of the respiratory apparatus. Finally, the tests during effort help to evaluate, more specifically, the effects of a treatment [less ▲]

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See detailBiosynthesis of 5-aminolevulinic acid via the Shemin pathway in a green sugar beet callus
Bisbis, Badia; Billard, Jean-Pierre; Huault, Claude et al

in Biologia Plantarum (1998), 40(4), 493-497

5-Aminolevulinic acid synthase (ALAS) has been detected in a normal (auxin- and cytokinin-dependent) green sugar beet callus under light and under darkness. ALAS activity was lower when the callus was ... [more ▼]

5-Aminolevulinic acid synthase (ALAS) has been detected in a normal (auxin- and cytokinin-dependent) green sugar beet callus under light and under darkness. ALAS activity was lower when the callus was grown under light. The supply of precursors of the Shemin pathway (glycine and succinate) to dark-grown callus enhanced considerably the capacity of the 5-aminolevulinic acid (ALA) formation. Glutamate, gamma-aminobutyrate or a-ketoglutarate also increased ALA accumulation. Such an accumulation was also obtained after inhibition of polyamine synthesis. The results show that glutamate or its derivatives might feed the Shemin pathway in conditions preventing glutamate to be used through the Beale pathway. [less ▲]

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See detailHematopoietic recovery in cancer patients after transplantation of autologous peripheral blood CD34+ cells or unmanipulated peripheral blood stem and progenitor cells.
Beguin, Yves ULg; Baudoux, Etienne ULg; Sautois, Brieuc ULg et al

in Transfusion (1998), 38(2), 199-208

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS ... [more ▼]

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS: Peripheral blood stem and progenitor cells (PBPCs) were collected from 32 patients, and 17 CD34+ cell-selection procedures were carried out in 15 of the 32. One patient in whom two procedures failed to provide 1 x 10(6) CD34+ cells per kg was excluded from further analysis. After conditioning, patients received CD34+ cells (n = 10, CD34 group) or unmanipulated (n = 17, PBPC group) PBPCs containing equivalent amounts of CD34+ cells or progenitors. RESULTS: The yield of CD34+ cells was 53 percent (18-100) with a purity of 63 percent (49-82). The CD34+ fraction contained 66 percent of colony-forming units--granulocyte-macrophage (CFU-GM) and 58 percent of CFU of mixed lineages, but only 33 percent of burst-forming units-erythroid (BFU-E) (p < 0.05). Early recovery of neutrophils and reticulocytes was identical in the two groups, although a slight delay in platelet recovery may be seen with CD34+ cell selection. Late hematopoietic reconstitution, up to 1.5 years after transplant, was also similar. The two groups were thus combined for analyses of dose effects. A dose of 40 x 10(4) CFU-GM per kg ensured recovery of neutrophils to a level of 1 x 10(9) per L within 11 days, 15 x 10(4) CFU of mixed lineages per kg was associated with platelet independence within 11 days, and 100 x 10(4) BFU-E per kg predicted red cell independence within 13 days. However, a continuous effect of cell dose well beyond these thresholds was apparent, at least for neutrophil recovery. CONCLUSION: CD34+ cell selection, despite lower efficiency in collecting BFU-E, provides a suitable graft with hematopoietic capacity comparable to that of unmanipulated PBPCs. In both groups, all patients will eventually show hematopoietic recovery of all three lineages with 1 x 10(6) CD34+ cells per kg or 5 x 10(4) CFU-GM per kg, but a dose of 5 x 10(6) CD34+ cells or 40 x 10(4) CFU-GM per kg is critical to ensure rapid recovery. [less ▲]

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See detailA novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns.
Singh, N. A.; Charlier, Carole ULg; Stauffer, D. et al

in Nature Genetics (1998), 18(1), 25-9

Idiopathic generalized epilepsies account for about 40% of epilepsy up to age 40 and commonly have a genetic basis. One type is benign familial neonatal convulsions (BFNC), a dominantly inherited disorder ... [more ▼]

Idiopathic generalized epilepsies account for about 40% of epilepsy up to age 40 and commonly have a genetic basis. One type is benign familial neonatal convulsions (BFNC), a dominantly inherited disorder of newborns. We have identified a sub-microscopic deletion of chromosome 20q13.3 that co-segregates with seizures in a BFNC family. Characterization of cDNAs spanning the deleted region identified one encoding a novel voltage-gated potassium channel, KCNQ2, which belongs to a new KQT-like class of potassium channels. Five other BFNC probands were shown to have KCNQ2 mutations, including two transmembrane missense mutations, two frameshifts and one splice-site mutation. This finding in BFNC provides additional evidence that defects in potassium channels are involved in the mammalian epilepsy phenotype. [less ▲]

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See detailPrenatal diagnosis of pyruvate carboxylase defiency by direct measurement of catalytic activity on chorionic villi samples
Van Coster; Janssens, S.; Misson, Jean-Paul ULg et al

in Prenatal Diagnosis (1998), 18

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See detailbeta-lactamases as models for protein-folding studies
Vanhove, M.; Lejeune, Annabelle ULg; Pain, R. H.

in Cellular and Molecular Life Sciences : CMLS (1998), 54(4), 372-377

This review traces some of the key features of the folding of beta-lactamases and their relevance to the way proteins fold in general. Studies on the enzymes have highlighted the nature and role of ... [more ▼]

This review traces some of the key features of the folding of beta-lactamases and their relevance to the way proteins fold in general. Studies on the enzymes have highlighted the nature and role of equilibrium and transient condensed states. The kinetics of folding are multiphasic, and when monitored by acrylamide quenching of the tryptophan fluorescence, an early phase provides evidence for the transient accumulation of a nonnative intermediate involving burial of tryptophan in a nonpolar environment. Intermediate phases can be understood in terms of progressive folding of different parts of the molecule. The later, slow phases are associated with proline isomerization in the TEM-1 enzyme and, in its P167T mutant form, with isomerization from trans to cis of the E166 T167 peptide bond. Coupled with kinetic and X-ray crystallographic studies of the beta-lactamase from Staphylococcus aureus and its D179Q mutant, it appears that the final stage of folding is that of collapse and packing of the Omega-loop on to the main body of the protein. [less ▲]

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See detailL'arbre que cache la forêt
Duchesne, Jean-Patrick ULg

in Art&fact (1998), 17

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See detailProtein composition and agglomeration tendency of gluten isolated from European wheats (Triticum aestivum L.) in a batter system
Roels, S. P.; Sindic, Marianne ULg; Deroanne, Claude et al

in Journal of Agricultural and Food Chemistry (1998), 46(4), 1344-1349

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons ... [more ▼]

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons) resulted in, on average, gluten yields of 9.6% (4.7-13.2% range). Gluten protein recoveries averaged 63.0% (34.5-85.7% range). Gluten yields and gluten protein recoveries were linearly related and increased when mixing times and baking absorptions required for optimal dough development of the parent flours increased, indicating that there is a relationship between the agglomeration properties of gluten proteins in a batter system and the optimal technological conditions necessary for processing the flours in breadmaking. The Osborne protein fractions in the gluten fractions were determined. The 0.05 M acetic acid soluble (glutenin) fraction was quantitatively the most important fraction (40-46% of gluten Kjeldahl nitrogen) while comparable levels of 70% ethanol soluble (gliadins) and 0.05 M acetic acid insoluble (residue protein) were found (17.9-22.3% of gluten Kjeldahl nitrogen and 22.0-29.0% of gluten Kjeldahl nitrogen for gliadins and residue protein, respectively). With decreasing pore size of the sieves, the level of glutenin in the gluten decreased while the level of gliadins increased. This indicates that, in gluten with good agglomeration properties, the level of glutenins is high and that the agglomeration properties of such proteins (i.e. their tendency to aggregate) strongly determines the agglomeration behavior of the gluten as a whole. [less ▲]

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See detailEvaluation of false ultrasonographic pregnancy diagnoses in cows by measuring plasma levels of bovine pregnancy-associated glycoprotein 1 (bPAG1).
Szenci, Otto; Taverne, M. A. M.; Beckers, Jean-François ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 142(2), 304-306

Between days 27 and 59 after artificial insemination (AI),189 ultrasonographic pregnancy diagnoses were made in 56 dairy cows using a 7·5 MHz linear-array rectal transducer. Blood samples were withdrawn ... [more ▼]

Between days 27 and 59 after artificial insemination (AI),189 ultrasonographic pregnancy diagnoses were made in 56 dairy cows using a 7·5 MHz linear-array rectal transducer. Blood samples were withdrawn from a jugular vein on the day of AI, on day 21, and after each ultrasonographic examination between days 27 and 31, days 34 and 38, days 41 and 45 and days 55 and 59 after AI. Plasma concentrations of bovine pregnancy-associated glycoprotein 1 (bPAG-1) were measured by radioimmunoassay. The results showed that before day 31, ultrasonographic scanning was not very sensitive because six of the 30 calving cows were incorrectly diagnosed as non-pregnant. In five of these animals, the uterus was located far cranial to the pelvic inlet. Five of the cows examined between days 27 and 31 were pregnant on the basis of plasma bPAG-1 levels on the same day, using 0·5 ng/ml as the cut-off point. Plasma levels of bPAG-1 and progesterone proved that four of the cows which had early positive ultrasonographic diagnoses but did not produce a calf, were pregnant when they were examined. [less ▲]

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See detailClinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials.
Scheen, André ULg

in Diabètes & Métabolism (1998), 24(4), 311-20

Acarbose, an alpha-glucosidase inhibitor, is a new antihyperglycaemic agent which has been proposed as add-on therapy in Type 2 diabetic patients not well-controlled with diet alone, sulphonylurea ... [more ▼]

Acarbose, an alpha-glucosidase inhibitor, is a new antihyperglycaemic agent which has been proposed as add-on therapy in Type 2 diabetic patients not well-controlled with diet alone, sulphonylurea, metformin or insulin, and in Type 1 diabetic patients with large meal-related plasma glucose excursions. Numerous controlled studies investigating the clinical effects of acarbose in Type 2 diabetes versus either placebo or, more rarely, versus a reference drug (sulphonylurea or metformin) have been published during the last 10 years. All placebo-controlled studies have demonstrated the superiority of acarbose, at a dose of 150-600 mg/day, in decreasing fasting and postprandial glucose levels as well as HbA1c concentrations (mean decrease of 0.7%), whether acarbose was given as first-line therapy in diet-treated diabetic patients or in combination in individuals already receiving a sulphonylurea, metformin or insulin. Only a few controlled studies have compared the effects of acarbose with those of either sulphonylurea or metformin, yielding controversial results. In Type 1 diabetic patients, a small reduction of HbA1c levels was also reported after addition of acarbose to insulin therapy, which in some cases allowed a slight reduction of daily insulin needs. All these favourable biological effects occurred without exposing the patient to hypoglycaemia or weight gain. A few studies have also reported favourable effects on postprandial lipid profile and some other vascular risk factors. However, it is not clear whether the extra cost of acarbose, when compared to that of older oral antidiabetic agents, is justified since no study has yet demonstrated its potential benefit on the complications and long-term prognosis of diabetic patients. [less ▲]

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See detailDe l'etude des alterations biochimiques du muscle squelettique ischémie et reperfuse à la reperfusion contrôlée des membres chez des patients en ischemie aigue severe
Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1998), 53(2), 91-7

The reperfusion of a limb which has been submitted to a severe and prolonged period of ischemia may be followed by dramatic local and systemic complications. The results of several experimental studies ... [more ▼]

The reperfusion of a limb which has been submitted to a severe and prolonged period of ischemia may be followed by dramatic local and systemic complications. The results of several experimental studies have given insights on the biochemical and physiopathological alterations occurring in the ischemic and reperfused skeletal muscle. Therefore the technique of the controlled limb reperfusion has been developed. we present the results obtained in two patients with this technique. Two patients were admitted for a limb-threatening ischemia consecutive to embolism. After removal of the thrombi with a Fogarty's catheter and before reperfusion with the normal blood, a controlled limb reperfusion was performed by mixing the systemic blood with a crystalloid solution in order to obtain a hyperosmolar, hypocalcemic, alcalotic and substrate-enriched (aspartate and glutamate) reperfusate. This reperfusate was infused during 30 min with a roller pump into the deep and superficial femoral arteries. The delivery conditions (temperature, flow and reinjection pressure) were closely monitored. In both cases, no post-operative complication was observed and the pedal pulses were restored after the operation. Complete recovery of the motor and sensitive functions were observed and the patient were discharged at the 10th post-operative day. [less ▲]

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See detailOiseau, d'où viens-tu?
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (1998), 31(8), 20-22

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See detailLa trichonémose larvaire chez le cheval : examens complémentaires et nouvelles approches thérapeutiques et prophylactiques
Losson, Bertrand ULg; Mignon, Bernard ULg

in Monde Vétérinaire (Le) : European Veterinary Magazine (1998), 45

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See detailVirulence Plasmids of Enterotoxigenic Escherichia Coli Isolates from Piglets
Mainil, Jacques ULg; Daube, Georges ULg; Jacquemin, Etienne et al

in Veterinary Microbiology (1998), 62(4), 291-301

Virulence plasmids of 68 ETEC isolates from piglets belonging to different pathotypes and six ETEC isolates from calves with pathotypes typical of porcine ETEC were identified with seven virulence probes ... [more ▼]

Virulence plasmids of 68 ETEC isolates from piglets belonging to different pathotypes and six ETEC isolates from calves with pathotypes typical of porcine ETEC were identified with seven virulence probes for the heat-stable (STa and STb) and heat-labile (LT) enterotoxins, for the F4, F5, F6, and F41 fimbrial adhesion subunit, and also with five Rep probes for the RepFIA and RepFIB basic replicons, and the RepFIC family of basic replicons. With the exception of the F41 probe, the other virulence probes hybridized with at least one plasmid band of a size range from 65 to more than 100 Mda. Common associations of virulence factor-encoding genes on plasmid bands were: STb/LT, STa/F5, STa/F6, STa/STb. Other associations, STa/F4, STa/F4/F6, and STa/STb/LT/F6, were rarer. On the other hand the F4 adhesin-encoding genes were isolated on one plasmid band in all but three F4+ isolates. All but one of the 92 virulence plasmids which were studied have Rep probe hybridization profiles and replicon types typical of the uni- or multireplicon plasmids belonging to the various incompatibility groups of the F incompatibility complex. [less ▲]

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See detailShoshonitic liquid line of descent from diorite to granite: the Late Precambrian post-collisional Tismana pluton (South Carpathians, Romania)
Duchesne, Jean-Clair ULg; Berza, Tudor; Liégeois, Jean-Paul ULg et al

in Lithos (1998), 45

The post-collision late-kinematic Tismana pluton belongs to the shoshonitic series. It is part of a Late Precambrian basement within the Alpine Danubian nappes of the South Carpathians (Romania). This ... [more ▼]

The post-collision late-kinematic Tismana pluton belongs to the shoshonitic series. It is part of a Late Precambrian basement within the Alpine Danubian nappes of the South Carpathians (Romania). This pluton displays an exceptionally complete range of compositions from ultramafic to felsic rocks (granites). Widespread mingling/mixing relationships at all scales give rise to a variety of facies. A liquid line of descent from the diorites to the granites is reconstructed by considering the variation in major and trace elements (REE, Sr, Rb, Ba, Nb, Zr, Hf, Zn, V, Co, Cr, U, Th, Ga, Pb) from 33 selected samples as well as mineral/melt equilibrium relationships. The first step of fractional crystallization is the separation from a monzodioritic parent magma of a peridotitic cumulate similar to the ultramafic rock found in the massif. A possible contamination by lower crustal mafic component takes place at this stage. The second step marks the appearance of apatite and Fe-Ti oxide minerals as liquidus phases, and the third step, saturation of zircon. Mixing by hybridisation of magmas produced at different stages of the evolution along the liquid line of descent is also operating (endo-hybridisation). As depicted by Nd and Sr isotopes, fractional crystallization was combined to an important early contamination by a mafic lower crust in a deep-seated magma chamber and to a later and mild contamination by a felsic medium crust in an intermediate chamber. The mingling essentially occurred during the final emplacement in the high-level magma chamber. The monzodioritic parent magma, identified by major and trace element modelling, is shown by Sr and Nd isotopes to have its source in the lithospheric mantle or in a juvenile mafic lower crust derived from it. The necessarily recent enrichment in K2O and associated elements of the lithospheric mantle is likely to be related to the preceding Pan-African subduction period. The partial melting of this newly formed deep source has to be linked to a major change in the thermal state of the plate. [less ▲]

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See detailLe juste entre formalisme et substantialisme. Etude comparative des jugements émis par des Tunisiens et des Français à propos d’une pratique coutumière de justice corrective
Nachi, Mohamed ULg

in Science Information/Information sur les sciences sociales (1998), 37(4), 547-592

Dans cet article, l’auteur se propose d’étudier le sens de la justice à partir d’un « cas » empirique recueilli en Tunisie et soumis à l’appréciation et au jugement de Tunisiens mais aussi de Français ... [more ▼]

Dans cet article, l’auteur se propose d’étudier le sens de la justice à partir d’un « cas » empirique recueilli en Tunisie et soumis à l’appréciation et au jugement de Tunisiens mais aussi de Français. L’examen des différentes espèces de justice établies par Aristote conduit à préciser les contours du tanfîl en tant qu’institution de partage mettant en oeuvre des règles de justice distributive et à montrer en quoi il s’agit dune forme de justice corrective sui generis. Après avoir éclairci la question du rapport aux normes, à travers la notion d’invocation des normes, et la question de la qualification, en comparant qualification juridique et qualification ordinaire, l’article analyse les formes d’argumentation et de justification que les Tunisiens et les Français interrogés mobilisent pour faire valoir leurs sens de la justice. L’analyse révèle deux types principaux de concepts de justice distributive : celle dans laquelle la légalité et le formalisme occupent une place prépondérante et celle où la primauté est accordée au contenu, à la substance, de la règle de justice. Tandis que dans le premier type le juste se confond avec le légal, dans le second non seulement il s’en distingue mais peut même s’y opposer, car ce qui est légal peut être injuste. L’auteur montre en particulier, en partant de la trilogie du juste chez Ricœur, dune part, que le compromis requiert une place de premier plan, et d’autre part, que l’idée de justice ne peut trouver sa pleine signification que dans une posture intermédiaire entre le légal et le bon, entre le formel et le substantiel. [less ▲]

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See detailPreserved artificial grammar learning in Parkinson's disease
Meulemans, Thierry ULg; Peigneux, Philippe ULg; Van der Linden, Martial ULg

in Brain & Cognition (1998), 37(1), 109-112

Parkinson's disease (PD) patients and matched control subjects were compared in an artificial grammar learning task. The test strings were constructed in such a way that grammaticality judgments could not ... [more ▼]

Parkinson's disease (PD) patients and matched control subjects were compared in an artificial grammar learning task. The test strings were constructed in such a way that grammaticality judgments could not be based on some superficial features of the learning strings: the grammatical and nongrammatical test strings did not differ according to different measures of chunk strength (based on the frequency with which their bigrams and trigrams appear in the learning strings). Results show that PD patients and controls performed at the same level during the first presentation of the test strings series, which suggests that the striatum is not (crucially) implicated in the ability to abstract rules implicitly from exemplars generated by a finite-state grammar. However, and contrary to control subjects, the classification performance of PD patients was at chance during the second presentation of the test strings. We argue that this latter result could be the consequence of the attentional deficit of PD patients. [less ▲]

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See detailOral antidiabetic agents. A guide to selection.
Scheen, André ULg; Lefebvre, Pierre ULg

in Drugs (1998), 55(2), 225-36

Type 2 diabetes mellitus (formerly named non-insulin-dependent diabetes mellitus or NIDDM) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin ... [more ▼]

Type 2 diabetes mellitus (formerly named non-insulin-dependent diabetes mellitus or NIDDM) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. Various pharmacological approaches can be used to improve glucose homeostasis via different modes of action: sulphonylureas essentially stimulate insulin secretion, biguanides (metformin) act by promoting glucose utilisation and reducing hepatic-glucose production, alpha-glucosidase inhibitors (acarbose) slow down carbohydrate absorption from the gut and thiazolidinediones (troglitazone) enhance cellular insulin action on glucose and lipid metabolism. These pharmacological treatments may be used individually for certain types of patients, or may be combined in a stepwise fashion to provide more ideal glycaemic control for most patients. Selection of oral antihyperglycaemic agents as first-line drug or combined therapy should be based on both the pharmacological properties of the compounds (efficacy and safety, profile) and the clinical characteristics of the patient (stage of disease, bodyweight, etc.). Mildly hyperglycaemic patients should preferably be treated with metformin, acarbose or thiazolidinediones (which are not associated with any hypoglycaemic risk), while more severely hyperglycaemic individuals should receive a sulphonylurea. In moderately hyperglycaemic patients, sulphonylureas should be preferred in nonobese patients while metformin, and probably also thiazolidinediones, should have priority in obese insulin-resistant type 2 diabetic patients. Acarbose is mainly indicated to reduce post-prandial glucose fluctuations and improve glycaemic stability. Each antihyperglycaemic agent may also be combined with insulin therapy to improve glycaemic control and/or reduce the insulin requirement of diabetic patients after secondary failure to oral treatment. Finally, safety should be taken into account in elderly patients and/or those with renal impairment, especially as far as the use of sulphonylureas (higher risk of hypoglycaemia) and metformin (higher risk of lactic acidosis) is concerned. [less ▲]

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See detailCase Management voor geriatrische patienten en hun families : Het klinisch model van belgische projecten
Borgermans, L.; Abraham, I.; Milisen, K. et al

in Tijdschrift voor de Geschiedenis der Geneeskunde, Natuurwetenschappen, Wiskunde en Techniek (1998), 54(6), 427-435

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See detailLatinitas-Peregrinitas. Purisme et nationalisme linguistique chez les grammairiens latins
Rochette, Bruno ULg

in Orbis : Bulletin international de documentation linguistique (1998), 40

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See detailLa chirurgie sous hypnosedation. Une nouvelle approche therapeutique pour l'hyperparathyroidie.
Defechereux, Thierry ULg; Faymonville, Marie ULg; Joris, Jean ULg et al

in Annales de Chirurgie (1998), 52(5), 439-43

The elective unilateral approach, sometimes under local anaesthesia, offers many advantages in terms of less invasive and faster surgical approach compared to the conventional surgery under general ... [more ▼]

The elective unilateral approach, sometimes under local anaesthesia, offers many advantages in terms of less invasive and faster surgical approach compared to the conventional surgery under general anaesthesia. Nevertheless this approach is restricted to patients unsuspected of multiglandular disease, free from thyroid disease and for whom localization studies are contributive. Surgery under hypnosedation offers the same advantages and provides the possibility of not only exploring the four glands but also of performing a partial thyroidectomy if needed. In our experience 21 patients underwent a cervicotomy under hypnosedation for primary hyperparathyroidism (HPT). No conversion to general anaesthesia was needed; mean operative time was 52 +/- 16 min. In 17 cases, HPT was due to a single adenoma, in 3 cases to hyperplasia (among them a MEN-1 case), and in one last case to a double adenoma. The four glands were identified in 85%. With a follow-up running from 4 to 45 months, all patients are cured. Hypnosedation offers the same medical and economic advantages than the unilateral access under local anaesthesia. Moreover indications are not restricted to selected patients. [less ▲]

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See detailEffects of exercise on neuroendocrine secretions and glucose regulation at different times of day.
Scheen, André ULg; Buxton, O. M.; Jison, M. et al

in American Journal of Physiology (1998), 274(6 Pt 1), 1040-9

To study the effects of time of day on neuroendocrine and metabolic responses to exercise, body temperature, plasma glucose, insulin secretion rates (ISR), and plasma cortisol, growth hormone (GH) and ... [more ▼]

To study the effects of time of day on neuroendocrine and metabolic responses to exercise, body temperature, plasma glucose, insulin secretion rates (ISR), and plasma cortisol, growth hormone (GH) and thyrotropin (TSH) were measured in young men, both at bed rest and during a 3-h exercise period (40-60% maximal O2 uptake). Exercise was performed at three times of day characterized by marked differences in cortisol levels, i.e., early morning (n = 5), afternoon (n = 8), and around midnight (n = 9). The subjects were kept awake and fasted, but they received a constant glucose infusion to avoid hypoglycemia. Exercise-induced elevations of temperature were higher in the early morning than at other times of day. The exercise-induced glucose decrease was approximately 50% greater around midnight, when cortisol was minimal and not stimulated by exercise, than in the afternoon or early morning (P < 0.05). This effect of time of day appeared unrelated to decreases in ISR or increases in temperature and GH. Robust TSH increases occurred in all exercise periods and were maximal at night. The results demonstrate the existence of circadian variations in neuroendocrine and metabolic responses to exercise. [less ▲]

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See detailLe Forestor Vertex: une nouvelle génération de dendromètres.
Rondeux, Jacques ULg; Pauwels, D.

in Revue Forestière Française (1998), 50(1), 59-64

The new generation of hypsometers, of which the Swedish Forestor Vertex is representative, use ultrasonic pulses to determine heights from 0 to 100 m, as well as distances and angles. The authors describe ... [more ▼]

The new generation of hypsometers, of which the Swedish Forestor Vertex is representative, use ultrasonic pulses to determine heights from 0 to 100 m, as well as distances and angles. The authors describe the operating principle for this hypsometer and point out some precautions that should be taken when using it. They highlight its main advantages and provide data on its precision. [less ▲]

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See detailDynamic surface properties of the proteose-peptone fraction of bovine milk
Innocente, N.; Corradini, C.; Blecker, Christophe ULg et al

in Journal of Dairy Science (1998), 81(7), 1833-1839

Proteose-peptone is a heat-stable and acid-soluble protein fraction of milk that has important functional properties. Component 3, which is the most hydrophobic fraction, appears to be largely responsible ... [more ▼]

Proteose-peptone is a heat-stable and acid-soluble protein fraction of milk that has important functional properties. Component 3, which is the most hydrophobic fraction, appears to be largely responsible for the physicochemical properties of proteose-peptones and for their important biological role in milk. In this study, total proteose-peptone was prepared from bulk skim milk by precipitation with ammonium sulfate, and the hydrophobic fraction was purified by FPLC(R) (Pharmacia Fine Chemicals, Uppsala, Sweden). The drop volume method was used to investigate the dynamic surface activity of total proteose-peptone and component 3 of proteose-peptone at the air-water interface and at the oil-water interface. In general, proteose-peptones are good surfactants at both interfaces. Of all proteose-peptones, component 3 causes a more rapid reduction of interfacial tension in both interfaces. A system for measuring film balance was used to obtain more information about the surface and mechanical properties of proteose-peptone monolayers. We deduced from the compression isotherms that component 3 of proteose-peptone and total proteose-peptone films spread at the air-water interface present different mechanical properties. [less ▲]

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See detailStructured imagination of novel creatures' faces
Brédart, Serge ULg; Ward, T. B.; Marczewski, P.

in American Journal of Psychology (The) (1998), 111(4), 607-625

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See detailA General Environment for the Treatment of Discrete Problems and its Application to the Finite Element Method
Dular, Patrick ULg; Geuzaine, Christophe ULg; Henrotte, F. et al

in IEEE Transactions on Magnetics (1998), 34(5), 3395--3398

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See detailThe phosphoprotein pp135 is an essential constituent of the fibrillar components of nucleoli and of coiled bodies.
Vandelaer, M.; Thiry, Marc ULg

in Histochemistry & Cell Biology (1998), 110(2), 169-77

We examined the distribution of the silver-stainable phosphoprotein, pp135, within Ehrlich tumor and HEp-2 cells by a postembedding Lowicryl immunogold labeling procedure. Identical labeling patterns were ... [more ▼]

We examined the distribution of the silver-stainable phosphoprotein, pp135, within Ehrlich tumor and HEp-2 cells by a postembedding Lowicryl immunogold labeling procedure. Identical labeling patterns were obtained in both cell types. During interphase, gold particles were found not only over the dense fibrillar component but were also evident over the fibrillar centers of nucleoli. By contrast, the granular component did not display any significant label. When rRNA synthesis was inhibited by actinomycin D, the same labeling was observed in segregated nucleoli; both fibrillar components were labeled. Aside from the nucleolar labeling, label was also consistently present in coiled bodies. During metaphase, label was visualized in silver-stainable material of the nucleolus organizing regions. It thus appears that, unlike the two major silver-stained proteins, nucleolin/C23 and B23, pp135 remains located in all major silver-stainable structures during the whole cell cycle. This finding strongly suggests that pp135 could be the component responsible for in situ silver staining. On the other hand, the maintenance of pp135 in the fibrillar centers throughout the cell cycle, like RNA polymerase I, upstream binding factor, and DNA topoisomerase I, suggests that pp135 could be a component involved in transcription of the rRNA genes. [less ▲]

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See detailLes annonces de librairie dans l'Elite des nouvelles (1717-1721)
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1998), 282

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See detailProtection against voltage collapse
Van Cutsem, Thierry ULg; Fernandez, Jose Luis; Henville, Charles F. et al

in ELECTRA (1998), (179), 110-126

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See detailCumulation and injury determination of the European Community in antidumping cases
Tharakan, P. K. M.; Greenaway, David; Tharakan, Joseph ULg

in Weltwirtschaftliches Archiv (1998)

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See detailHemodynamic changes induced by laparoscopy and their endocrine correlates: effects of clonidine.
Joris, Jean ULg; Chiche, Jean-Daniel; Canivet, Jean-Luc ULg et al

in Journal of the American College of Cardiology (1998), 32(5), 1389-96

OBJECTIVES: We investigated endocrine correlates of the hemodynamic changes induced by carbon dioxide pneumoperitoneum (PNO). We then studied whether clonidine might modulate the hemodynamic changes ... [more ▼]

OBJECTIVES: We investigated endocrine correlates of the hemodynamic changes induced by carbon dioxide pneumoperitoneum (PNO). We then studied whether clonidine might modulate the hemodynamic changes induced by PNO by reducing release of catecholamines and vasopressin. BACKGROUND: Both mechanical and neurohumoral factors contribute to the hemodynamic changes induced by carbon dioxide PNO. Several mediators have been proposed, but no study has correlated hemodynamic changes with changes in levels of these potential mediators. METHODS: We conducted two studies, each including 20 healthy patients scheduled for elective laparoscopic cholecystectomy. In the first study serial measurements of hemodynamics (thermodilution technique) were done during laparoscopy and after exsufflation. Plasma concentrations of cortisol, catecholamines, vasopressin, renin, endothelin and prostaglandins were measured at the same time points. In the second study patients were randomly allocated to receive 8 microg/kg clonidine infused over 1 h or placebo before PNO. Hemodynamics and plasma levels of cortisol, catecholamines and vasopressin were measured during PNO and after exsufflation. RESULTS: Peritoneal insufflation resulted in a significant reduction of cardiac output (18+/-4%) and increases in mean arterial pressure (39+/-8%) and systemic (70+/-12%) and pulmonary (98+/-18%) vascular resistances. Laparoscopy resulted in progressive and significant increases in plasma concentrations of cortisol, epinephrine, norepinephrine and renin. Vasopressin plasma concentrations markedly increased immediately after the beginning of PNO (before PNO 6+/-4 pg/ml; during PNO 129+/-42 pg/ml; p < 0.05). The profile of vasopressin release paralleled the time course of changes in systemic vascular resistance. Prostaglandins and endothelin did not change significantly. Clonidine significantly reduced mean arterial pressure, heart rate and the increase in systemic vascular resistance. Clonidine also significantly reduced catecholamine concentrations but did not alter vasopressin and cortisol plasma concentrations. CONCLUSIONS: Vasopressin and catecholamines probably mediate the increase in systemic vascular resistance observed during PNO. Clonidine before PNO reduces catecholamine release and attenuates hemodynamic changes during laparoscopy. [less ▲]

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See detailVector mesons from tensor couplings in the NJL model
Jaminon, Martine ULg; Ruiz Arriola, Enrique

in Physics Letters B (1998), 443

We propose to describe vector mesons in a pure quark model such as the one of Nambu and Jona-Lasinio by means of four point tensor interactions, but with vanishing vector and axial couplings. This becomes ... [more ▼]

We propose to describe vector mesons in a pure quark model such as the one of Nambu and Jona-Lasinio by means of four point tensor interactions, but with vanishing vector and axial couplings. This becomes possible due to tensor-vector mixing at the one quark loop level. As a consequence a bound particle with rho quantum numbers is generated. This has the advantage of avoiding the A-pi mixing which is known to generate a wrong off-shell pion wave function renormalization. In addition, there is no A1 meson. We make our arguments quantitative by computing Euclidean correlators via dispersion relations and comparing with lattice QCD and random instanton model results. [less ▲]

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See detailContribution Of The Hydrophobicity Gradient Of An Amphipathic Peptide To Its Mode Of Association With Lipids
Perez-Mendez, O.; Vanloo, B.; Decout, A. et al

in European Journal of Biochemistry (1998), 256(3), 570-9

A class of peptides that associate with lipids, known as oblique-orientated peptides, was recently described [Brasseur R., Pillot, T., Lins, L., Vandekerckhove, J. & Rosseneu, M. (1997) Trends Biochem ... [more ▼]

A class of peptides that associate with lipids, known as oblique-orientated peptides, was recently described [Brasseur R., Pillot, T., Lins, L., Vandekerckhove, J. & Rosseneu, M. (1997) Trends Biochem. Sci. 22, 167-171]. Due to an asymmetric distribution of hydrophobic residues along the axis of the alpha-helix, such peptides adopt an oblique orientation which can destabilise membranes or lipid cores. Variants of these oblique peptides, designed to have an homogeneous distribution of hydrophobic and hydrophilic residues along the helical axis, are classified as regular amphipathic peptides. These peptides are expected to lie parallel to the polar/apolar interface with their hydrophobic residues directed towards the apolar and their hydrophilic residues towards the polar phase. An hydrophobic, oblique-orientated peptide was identified at residues 56-68 in the sequence of the lecithin-cholesterol acyltransferase (LCAT), enzyme. This peptide is predicted to penetrate a lipid bilayer at an angle of 40 degrees through its more hydrophobic C-terminal end and thereby induce the destabilisation of a membrane or a lipid core. The LCAT-(56-68) wild-type peptide was synthesised together with the LCAT-(56-68, 0 degrees) variant, in which the hydrophobicity gradient was abolished through residue permutations. In two other variants, designed to keep their oblique orientation, the W61 residue was shifted either towards the more hydrophilic N-terminal at residue 57, or to position 68 at the hydrophobic C-terminal end of the peptide. Peptide-induced vesicle fusion was demonstrated by fluorescence measurements using pyrene-labeled vesicles and by monitoring of vesicle size by gel filtration. The interaction between peptides and lipids was monitored by measurement of the intrinsic tryptophan fluorescence emission of the peptides. Fluorescence polarisation measurements, using diphenyl hexatriene, were carried out to follow changes in the lipid fluidity. The LCAT-(56-68) wild-type peptide and the two oblique variants, induced fusion of unilamellar dimyristoylglycerophosphocholine vesicles. Tryptophan fluorescence emission measurements showed a 12-14 nm blue shift upon addition of the wild-type peptide and of the W61-->68 variant to lipids, whereas the fluorescence of the W61-->57 variant did not change significantly. This observation supports the insertion of the more hydrophobic C-terminal residues into the lipid phase, as predicted by the theoretical calculations. In contrast, the 0 degrees variant peptide had no fusogenic activity, and it associated with lipids to form small discoidal lipid/peptide complexes. The phospholipid transition temperature was decreased after addition of the wild-type, the W61-->68 and W61-->57 fusogenic peptides, whereas the opposite effect was observed with the 0 degrees variant. The behaviour of the wild-type and variant LCAT-(56-68) peptides stresses the contribution of the hydrophobicity gradient along the axis of an amphipathic peptide to the mode of association of this peptide with lipids. This parameter consequently influences the structural modifications occurring to lipids upon association with amphipathic peptides. [less ▲]

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See detailHerpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Acta Dermato Venereologica (1998), 78

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See detailThe effect of BaZrO3 addition on transport properties of Dy-based 123-211 composite materials: electrical resistivity, thermal conductivity and thermoelectric power
Bougrine, Hassan ULg; Ausloos, Marcel ULg; Pekala, M. et al

in Superconductor Science & Technology (1998), 11(8), 803-809

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power ... [more ▼]

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power have been measured. The electrical resistivity has also been measured in a magnetic field less than 1 T. The data show that BaZrO3 addition has a non-trivial effect: beside mildly reducing the critical temperature of the superconductor, it increases the scattering at small concentration, and effectively reduces weak link features in the electrical property, but increases the thermal conductivity. The field influence on T-c is shown to be T-c(O)- T-c(B) approximate to B-1/2. [less ▲]

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See detailQuelle place pour l'isocinétisme dans la rééducation de l'épaule?
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg

in Lettre de Médecine Physique et de Réadaptation (1998), 48

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See detailCytokinins and ethylene stimulate indole alkaloid accumulation in cell suspension cultures of Catharanthus roseus by two distinct mechanisms
Yahia, Abdelouahab; Kevers, Claire ULg; Gaspar, Thomas ULg et al

in Plant Science (1998), 133(1), 9-15

The interactions between cytokinins and ethylene on alkaloid accumulation in a periwinkle cell line have been examined. It was found that (a) either exogenously-applied cytokinins or ethylene (the latter ... [more ▼]

The interactions between cytokinins and ethylene on alkaloid accumulation in a periwinkle cell line have been examined. It was found that (a) either exogenously-applied cytokinins or ethylene (the latter through ethephon degradation) greatly enhanced ajmalicine accumulation in cells subcultured in a 2,4-dichlorophenoxyacetic acid-free medium; (b) the enhancing effect of cytokinin was not mediated by enhancement of endogenous ethylene production contrary to what is found in some plant models, (c) the responses to exogenous cytokinin and ethylene were additive and showed a different pattern of expression. It may be concluded that cytokinin and ethylene can up-regulate the alkaloid production in a periwinkle cells through independent pathways when added exogenously to the cultures. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailScintigraphical Evaluation of Alveolar Clearance in Horses
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, D. H. et al

in Veterinary Journal (1998), 156(1), 51-58

This study proposed a standardized method for measuring alveolar epithelium membrane permeability in the horse. The normal rate of clearance (%.min-1) from lung into blood of nebulized 99mTc-DTPA has been ... [more ▼]

This study proposed a standardized method for measuring alveolar epithelium membrane permeability in the horse. The normal rate of clearance (%.min-1) from lung into blood of nebulized 99mTc-DTPA has been established for healthy horses (Group A) compared with values obtained with horses suffering from chronic obstructive pulmonary disease (COPD; Group B). The 99mTc-DTPA clearance was measured in the caudoventral (R1) and in the half caudal (R2) parts of the left lung during different time intervals. The two regions aimed to define the influence of the airways on measured clearance (R2 contained proportionally more conducting airways than R1). It was concluded that a comparison of groups of subjects may be performed in R2 and on data collected during a 20 min period. The normal clearance rate in R2 was 1.80 +/- 0.46%.min-1 (T1/2R2 = 40.99 +/- 12.45 min) in Group A. In Group B, a significantly faster 99mTc-DTPA transfer rate was found (4.17 +/- 0.83%.min-1 or T1/2R2 = 17.17 +/- 3.38min). Bronchoalveolar lavage (BAL) suggested that the increased permeability measured in Group B could be the result of lung inflammatory responses. Our results have demonstrated the ability of the 99mTc-DTPA clearance test to detect alveolar epithelial damage in horses. Furthermore, we were able to show that a regional analysis of the alveolar-capillary barrier integrity may be performed satisfactorily in the equine patient. [less ▲]

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See detail3 ',4 ',5 ',6 ' tetradehydrolongicaudatine Y, an anhydronium base from Strychnos usambarensis
Frederich, Michel ULg; Quetin-Leclercq, J.; Biala, R. G. et al

in Phytochemistry (1998), 48(7), 1263-1266

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See detailQuelques orientations chiffrées sur l'accroissement des chênaies en région wallonne
Rondeux, Jacques ULg; Lecomte, Hugues; Florkin, Pierre et al

in Silva Belgica (1998), 105(3), 35-43

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See detailThe tridimensional personality questionnaire (TPQ) and depression.
Hansenne, Michel ULg; Pitchot, William ULg; Gonzalez Moreno, A. et al

in European Psychiatry (1998), 13(2), 101-3

The relationships between the Tridimensional Personality Questionnaire (TPQ) and depression were examined in a sample of 53 major depressive patients and 33 healthy controls. Depressed patients exhibit ... [more ▼]

The relationships between the Tridimensional Personality Questionnaire (TPQ) and depression were examined in a sample of 53 major depressive patients and 33 healthy controls. Depressed patients exhibit higher harm avoidance scores as well as lower novelty seeking sub-scale exploratory excitability (NS1) scores as compared to healthy controls. However, the other dimensions and their sub-scales do not differ between depressive patients and controls. In the depressive group, the harm avoidance dimension is related to the severity of depression as assessed by the Hamilton scale. This study confirms the state dependence of the harm avoidance dimension and suggests a relationship between the novelty seeking sub-scale NS1 and depression. [less ▲]

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See detailDynamic Recrystallization during Zinc Rolling
Habraken, Anne ULg; Charles, J.-F.; Wegria, J. et al

in International Journal of Forming Processes (1998), 1

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See detailFloating Population and Migration in China. The Impact of Economic Reforms
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (1998), Vol. XVI

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See detailLe rappresentazioni della relazione tra operatori e bambini autistici. Résultati di una ricerca.
D'Amore, Salvatore ULg; Onnis, Luigi

in Psicobiettivo (1998), 18(1), 103-121

Relationals representations constitute an important study area for understanding of interactive phenomena, especially, in the field of relationship between health care workers (medical doctors ... [more ▼]

Relationals representations constitute an important study area for understanding of interactive phenomena, especially, in the field of relationship between health care workers (medical doctors, psychotherapists, counsellors and so on) and patients because relational representations circularly influence mutual behaviours and expectations. This research suggests an observational model of the relational representations between a therapist and an autistic child. This model, based upon the use of metaphors and sculpting, put in evidence how the way the therapist represents the child and the relationship with him could have important implications on the therapeutic process as on its developments and issues. The subjectivity of the therapist and his personal aspects, consequently, become a crucial field of auto reflection: this requires adequate training courses and regular supervision experiences. [less ▲]

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See detailHomologous radioimmunoassay for bovine insulin-like growth factor-binding protein-2 (IGFBP-2)
Portetelle, Daniel ULg; Vleurick, Live; Massart, Serge et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 13

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See detailForaging and feeding ecology of the Serotine bat Eptesicus serotinus
KERVYN, Thierry; Brasseur, Jasmine; Motte, Grégory et al

in Bat Research News (1998), 39(3), 84

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See detailTopology Optimization of Continuum Structures with Local Stress Constraints
Duysinx, Pierre ULg; Bendsoe, Martin Philip

in International Journal for Numerical Methods in Engineering (1998), 43

We introduce an extension of current technologies for topology optimization of continuum structures which allows for treating local stress criteria. We rst consider relevant stress criteria for porous ... [more ▼]

We introduce an extension of current technologies for topology optimization of continuum structures which allows for treating local stress criteria. We rst consider relevant stress criteria for porous composite materials, initially by studying the stress states of the so-called rank 2 layered materials. Then, on the basis of the theoretical study of the rank 2 microstructures, we propose an empirical model which extends the power penalized sti ness model (also called SIMP for Solid Isotropic Microstructure with Penalization for intermediate densities). In a second part, solution aspects of topology problems are considered. To deal with the so-called 'singularity' phenomenon of stress constraints in topology design, an -constraint relaxation of the stress constraints is used. We describe the mathematical programming approach that is used to solve the numerical optimization problems, and show results for a number of example applications. [less ▲]

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See detailLow-productive alpha-herpesviridae infection in chronic lichenoid dermatoses
Nikkels, Arjen ULg; Sadzot-Delvaux, Catherine ULg; Rentier, Bernard ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1998), 196(4), 442-446

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative ... [more ▼]

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative pathomechanisms suggests an altered virus-host cell relationship. OBJECTIVE/METHODS: This report investigates by histology, immunohistochemistry and in situ hybridization the histological and virological features of 6 protracted, indolent HSV infections and 2 prolonged zoster infections. RESULTS: Histopathology revealed a lichenoid dermatitis in all patients. Specific HSV-1, HSV-2 and VZV in situ hybridization proved the viral origin of the cutaneous lesions. Immunohistochemical assessment demonstrated the intracellular presence of the HSV glycoproteins gB, gC and gD in epidermal keratinocytes which did not exhibit cytolysis. Similar findings were obtained for the VZV gE and gB. CONCLUSION: These results suggest that in some instances HSV and VZV infections may present a protracted disease course associated with a lichenoid inflammatory pattern and a non-cytolytic virus-host cell relationship. [less ▲]

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See detailMotor and somatosensory evoked potentials in cervical spondylotic myelopathy
MAERTENS DE NOORDHOUT, Alain ULg; MYRESSIOTIS, Sophie ULg; DELVAUX, Valérie ULg et al

in Electroencephalography and Clinical Neurophysiology (1998), 108

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See detailAn algorithmic approach for checking closure properties of temporal logic specifications and ω-regular languages
Peled, Doron; Wilke, Thomas; Wolper, Pierre ULg

in Theoretical Computer Science (1998), 195(2), 183--203

In concurrency theory, there are several examples where the interleaved model of concurrency can distinguish between execution sequences which are not significantly different. One such example is ... [more ▼]

In concurrency theory, there are several examples where the interleaved model of concurrency can distinguish between execution sequences which are not significantly different. One such example is sequences that differ from each other by stuttering, i.e., the number of times a state can adjacently repeat. Another example is executions that differ only by the ordering of independently executed events. Considering these sequences as different is semantically rather meaningless. Nevertheless, specification languages that are based on interleaving semantics, such as linear temporal logic (LTL), can distinguish between them. This situation has led to several attempts to define languages that cannot distinguish between such equivalent sequences. In this paper, we take a different approach to this problem: we develop algorithms for deciding if a property cannot distinguish between equivalent sequences, i.e., is closed under the equivalence relation. We focus on properties represented by regular languages, ω-regular languages, or prepositional LTL formulas and show that for such properties there is a wide class of equivalence relations for which determining closure is decidable, in fact is in PSPACE. Hence, checking the closure of a specification is no more difficult than checking satisfiability of a temporal formula. Among the closure properties we are able to handle, one finds trace closedness, stutter closedness and projective closedness, for all of which we are also able to prove a PSPACE lower bound. Being able to check that a property is closed under an equivalence relation has an immediate application in state-space exploration based verification. Indeed, the knowledge that the specification does not distinguish between equivalent execution sequences allows constructing a reduced state space where it is sufficient that at least one sequence per equivalence class is represented. [less ▲]

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See detailWorking memory deficits in Alzheimer's disease
Collette, Fabienne ULg; Van der Linden, Martial ULg; Bechet, Sophie ULg et al

in Brain and Cognition (1998), 37(1), 147-149

The phonological loop and central executive components of working memory were examined in patients with Alzheimer's disease (AD patients) and elderly controls. Patients with Alzheimer's disease showed ... [more ▼]

The phonological loop and central executive components of working memory were examined in patients with Alzheimer's disease (AD patients) and elderly controls. Patients with Alzheimer's disease showed reduced verbal spans, with smaller phonological similarity and word length effects. They also showed a decreased performance in tasks examining processing speed and articulation rate. However, phonological analysis was normal. With regard to the central executive, AD patients showed deficits in an alphabetical span task in which subjects were asked to recall a random series of words in their alphabetical order, while they performed normally on a dual task in which they had to perform simultaneously a digit repetition and a visuomotor task. These results suggests that Alzheimer's disease may affect several components of working memory but all aspects of the central executive mechanism are not necessarily affected. [less ▲]

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See detailProduction and kinematics of sodium atoms in the coma of comet Hale-Bopp
Arpigny, Claude ULg; Rauer, H.; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (1998), 334(Letters), 53-56

High-resolution spectra of sodium D line emission in comet Hale-Bopp (C/1995 O1) were obtained at the Observatoire de Haute-Provence, France, on 25-27 March and on 15-17 April, 1997. The observations have ... [more ▼]

High-resolution spectra of sodium D line emission in comet Hale-Bopp (C/1995 O1) were obtained at the Observatoire de Haute-Provence, France, on 25-27 March and on 15-17 April, 1997. The observations have been used to measure the velocity of sodium atoms in the coma within 2 10(5) km from the nucleus. A comparison between the March and April data provides an illustration of the influence of the heliocentric radial velocity on the strength of the fluorescence (Swings effect), and on the velocity of Na atoms achieved by solar radiation pressure acceleration. Evidence for the presence of a distributed source in the coma is found from the relatively high tailward velocities on the sunward side of the coma, in addition to the sunward extent of sodium emission up to 1.4 10(5) km in April. Based on observations secured at OHP (France) [less ▲]

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See detailLa paroi bactérienne et la résistance à la pénicilline: faits, questions et espoirs
Ghuysen, Jean-Marie ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1998), 153(4), 235-41

The simplest conceivable event at the level of the gene can result in the emergence of antibiotic-resistant determinants. The bacterial world behaves as an enormous organism the cells of which exchange ... [more ▼]

The simplest conceivable event at the level of the gene can result in the emergence of antibiotic-resistant determinants. The bacterial world behaves as an enormous organism the cells of which exchange their genes with great ease and, likewise, the opportunities for the exchange of genetic material in nature is, probably, limitless. This knowledge cannot be ignored. It leads to the important conclusion that the antibiotics are societal drugs. A resistance gene which has appeared somewhere in the world can travel far and fast. [less ▲]

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See detailCrystal structures of the psychrophilic a-amylase from Alteromonas haloplanctis in its native form and complexed with an inhibitor
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (1998), 7(6), 564-572

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See detailL1-protein in incipient lymphocyte-depleted graft-versus-host disease. Expression in keratinocytes and coexpression with Factor XIIIa in dermal cells
Pierard, Gérald ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Turkish Journal of Dermatology = Dermatopatoloji Dergisi (1998), 7

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated ... [more ▼]

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated cutaneous graft-versus-host reaction (GVHR) where the most straightful histologic clue was the epidermal L1-protein (calprotectin) expression revealed by a positive immunolabelling using the Mac 387 antibody. The epidermis looked otherwise normal and inflammatory cells were scant in the dermis. The expression of calprotectin by keratinocytes occurred early in cutaneous GVHR. In addition, CD45RO-positive T memory lymphocytes were exceedingly rare in the dermis while a few Mac 387-positive monocytes coexpressed Factor XIIIa immunoreactivity. Hyperplasia of the Factor XIIIa-positive dendrocytic population was obvious. Calprotectin and Factor XIIIa immunolagellings should be regarded as a diagnostic adjunct in lymphocyte-depleted cutaneous GVHR. Calprotectin positivity of the epidermis is indicative although not specific for such condition. However, its combination with a low lymphocytes/monocytes ratio in the dermis which is enriched in plup dendrocytes is almost diagnostic. [less ▲]

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See detailGribiche ou la leçon de choses. Note pour une théorie de l’allégorie au cinéma
Mélon, Marc-Emmanuel ULg

in 1895 : Bulletin de l'Association Française de Recherche sur l'Histoire du Cinéma (1998), Hors-série

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See detailLe Global Positioning System au service des sciences de la Terre
Warnant, René ULg

in Ciel et Terre (1998), 114(6), 166-173

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See detailEvaluation of the effect of two training regimes on the resumption of the ovarian activity by analysis of faecal 20 alpha-hydroxyprogesterone in trotter mares
Messina, Mariella; Prandi, Alberto; Bolelli, G. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2

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See detailComparaison des peuplements de diatomées épilithiques de ruisseaux acides en milieu forestier soumis à un amendement de dolomie (Massif Ardennais, Belgique)
Loncin, Anne; Leclercq, Louis ULg; Carnol, Monique ULg et al

in Annales de Limnologie (1998), 34(1), 13-22

Three to five years following application of dolomite (calcium magnesium carbonate) on some forest catchments in the belgian area of the Ardenne, epilithic diatoms were sampled in two streams running on ... [more ▼]

Three to five years following application of dolomite (calcium magnesium carbonate) on some forest catchments in the belgian area of the Ardenne, epilithic diatoms were sampled in two streams running on treated sites and in two streams running on untreated sites in order to evaluate the possible changes in the algal population. Typical acid water assemblages with Eunotia were observed. The dominant species was Eunotia exigua often found with E. rhomboidea or E. bilunaris. In the present study, no influence of the treatment can be demonstrated using these bioindicators. [less ▲]

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See detailCompte-rendu de Pascal Engel, La dispute. Une introduction à la philosophie analytique
Leclercq, Bruno ULg

in Revue Philosophique de Louvain (1998), 96

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See detailComment j'explore ... la néphropathie diabétique. Deuxième partie: suivi de la filtration glomérulaire
Weekers, Laurent ULg; Scheen, André ULg; Godon, J. P.

in Revue Médicale de Liège (1998), 53(9), 571-5

The natural history of diabetic renal disease can be divided into different stages according to the degree of albuminuria and the level of glomerular filtration rate (GFR). Assessment of the early ... [more ▼]

The natural history of diabetic renal disease can be divided into different stages according to the degree of albuminuria and the level of glomerular filtration rate (GFR). Assessment of the early hyperfiltration state, as well as determination of the rate of decline in kidney function at a later stage require precise and accurate methods to measure GFR. In this article, we briefly remind the reader of the physiological basis of GFR. We then review the different techniques for the monitoring of kidney function (inulin clearance, endogenous creatinine clearance, plasma disappearance of a radiolabelled tracer) and discuss the pro and cons of each of them in different clinical settings. Finally, we try to define a rational use of these techniques in everyday clinical practice. [less ▲]

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See detailPrise en compte des variations de la perméabilité et du coefficient d’emmagasinement spécifique dans les simulations hydrogéologiques en milieux argileux saturés
Dassargues, Alain ULg

in Bulletin de la Société Géologique de France (1998), 169(5), 665-673

It is well known that the consolidation of compressible silt-clay geological layers induces a decrease in porosity. Consequently, the hydraulic conductivity and the compressibility of the medium are also ... [more ▼]

It is well known that the consolidation of compressible silt-clay geological layers induces a decrease in porosity. Consequently, the hydraulic conductivity and the compressibility of the medium are also decreased and the hydrodynamic conditions changed. A full coupling between the groundwater flow and the subsidence processes must be taken into account with non-linear parameters. In saturated conditions, the specific storage coefficient is directly related to the volume compressibility of the medium; its evolution depends on the rheological law chosen to describe the consolidation of the medium. For the hydraulic conductivity, the choice of the variation law is more difficult and should be made in each case as a function of the experimental data and measurements. Comparisons are made between computations with constant and varying parameters. The computed pore pressures are strongly affected, automatically inducing the major differences in the calculated subsidences. Different laws of non-linearity for the hydraulic conductivity are tested on a practical case taken from the study of the land subsidence in Shanghai. This subsidence was induced by heavy groundwater withdrawal. [less ▲]

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See detailA formal definition of time in LOTOS
Léonard, Luc; Leduc, Guy ULg

in Formal Aspects of Computing (1998), 10(3), 248-266

Enhanced Timed-LOTOS, denoted ET-LOTOS, is an extension of LOTOS that allows the modelling of real-time behaviours. It covers all the aspects of full LOTOS, including data types, it supports both a dense ... [more ▼]

Enhanced Timed-LOTOS, denoted ET-LOTOS, is an extension of LOTOS that allows the modelling of real-time behaviours. It covers all the aspects of full LOTOS, including data types, it supports both a dense and a discrete time domain and can manipulate time values as any other data values. A tutorial on ET-LOTOS, showing many application examples, has already been published elsewhere. The present paper adds to it by providing an in-depth presentation of its theoretical aspects. The complete semantics is given and explained, and its proper-ties are studied. In particular, we prove that the semantics is consistent and that strong bisimulation is a congruence. This requires to deal carefully with the presence of negative premises in the operational semantics, which are necessary to express urgency. ET-LOTOS is also shown to be a conservative extension of LOTOS for guarded processes, and is the basis of the timed extension of LOTOS currently developed by ISO. To our knowledge, this is the first in-depth study of a language that combines data types and real-time behaviours. [less ▲]

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See detailElectronic contribution to the thermal diffusivity: DyBa2Cu3O7-y and Y0.9Ca0.1Ba2Cu3O7-z
Dorbolo, Stéphane ULg; Bougrine, Hassan ULg; Ausloos, Marcel ULg

in International Journal of Modern Physics B : Condensed Matter Physics, Statistical Physics, Applied Physics (1998), 12(29-31), 3087-3090

The electronic contribution to the specific heat and the thermal conductivity of high-T-c superconductors is calculated with a three-dimensional band structure including saddle points and a Lawrence ... [more ▼]

The electronic contribution to the specific heat and the thermal conductivity of high-T-c superconductors is calculated with a three-dimensional band structure including saddle points and a Lawrence-Doniach coupling between the CuO2 planes. The electronic thermal diffusivity is deduced for s- and d-wave symmetry of the order parameter. Data on DyBa2Cu3O7-y and Y0.9Ca0.1Ba2Cu3O7-z and theory are in good agreement on the change of the slope near T-c. [less ▲]

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