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See detailPrévention de l’ostéoporose
Reginster, Jean-Yves ULg

in Medi-Sphere (1997), 6

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See detailPostoperative spirometry after laparoscopy for lower abdominal or upper abdominal surgical procedures.
Joris, Jean ULg; Kaba, Abdourahmane ULg; Lamy, Maurice ULg

in British Journal of Anaesthesia (1997), 79(4), 422-6

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation ... [more ▼]

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation) (n = 10 in each group) to determine if lower abdominal laparoscopy results in less postoperative pulmonary dysfunction than upper abdominal laparoscopy. Pulmonary testing was performed before operation, and 3 and 6 h after operation, on the first and second days after surgery. After operation, a significant reduction in forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow rate occurred after laparoscopic cholecystectomy at each time. There were no significant changes after minor gynaecologic laparoscopy, whereas laparoscopic gynaecological surgery resulted in minor pulmonary dysfunction on the day of surgery only. We conclude that postoperative pulmonary function was less impaired after gynaecological laparoscopy than after laparoscopic cholecystectomy. This study suggests that the site of surgery is an important determinant of lung dysfunction after laparoscopy. [less ▲]

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See detailNo-carrier-added asymmetric synthesis of alpha-methyl-alpha-amino acids labelled with fluorine-18
Damhaut, Philippe; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Tetrahedron (1997), 53(16), 5785-5796

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential ... [more ▼]

Various [18F]fluoro aromatic α-methyl-L-amino acids 11 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential inhibitors of enzymatic functions, were regiospecifically labelled by nucleophilic substitution on trimethylammoniumbenzaldehyde triflate precursors 9. The [18F]fluoro aromatic aldehydes 12 obtained were easily converted to the corresponding [18F]fluorobenzyl halides [13 (X = 1)]. After alkylation of the lithium enolate of (2S,5S)-l-tert-Boc-2-tert-butyl-3,5-dimethyl-imidazolidin-4-one 2, the adducts were cleaved to give, after HPLC purification, various [18F]fluoro-α-methyl amino acid analogs with radiochemical yields of 10% (End of Bombardment, EOB) after a synthesis time of 120 min. The corresponding [19F]fluorinated amino acids 4 and [19F]fluoro intermediates were also prepared. [less ▲]

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See detailBovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro
Hulshof, S. C. J.; Figueiredo, J. R.; Beckers, Jean-François ULg et al

in Theriogenology (1997), 48

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral ... [more ▼]

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantal follicles. In addition, activin immunoreactivity was observed in the theca of secondary follicles. In addition, activin preantral follicles, activin increased follicular growth and granulosa cell proliferation in a dose-dependent manner. This increase was further stimulated by addition of FSH. In conclusion, activin and its receptor are present on bovine follicles, and additional activin stimulates development of those follicles. [less ▲]

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See detailSur les accents et les marques de quantité dans les papyrus latins
Rochette, Bruno ULg

in Zeitschrift für Papyrologie und Epigraphik (1997), 119

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See detailA Deletion in the Bovine Myostatin Gene Causes the Double-Muscled Phenotype in Cattle
Grobet, L.; Martin, L. J.; Poncelet, D. et al

in Nature Genetics (1997), 17(1), 71-74

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled ... [more ▼]

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-muscle hyperplasia-that is, an increase in the number of muscle fibers rather than in their individual diameter. Although the hereditary nature of the double-muscled condition was recognized early on, the precise mode of inheritance has remained controversial; monogenic (domainant and recessive), oligogenic and polygenic models have been proposed. In the Belgian Blue cattle breed (BBCB), segregation analysis performed both in experimental crosses and in the outbred population suggested an autosomal recessive inheritance. This was confirmed when the muscular hypertrophy (mh) locus was mapped 3.1 cM from microsatellite TGLA44 on the centromeric end of bovine chromosome 2 (ref. 5). We used a positional candidate approach to demonstrate that a mutation in bovine MSTN, which encodes myostatin, a member of the TGF beta superfamily, is responsible for the double-muscled phenotype. We report an 11-bp deletion in the coding sequence for the bioactive carboxy-terminal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle. [less ▲]

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See detailTell Amarna 1997
Tunca, Önhan ULg

in Chronique archéologique en Syrie 2 (1997)

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See detailL'abord coelioscopique des pheochromocytomes est-il acceptable? Reflexions a propos d'une etude prospective de 6 cas personnels.
Hamoir, Etienne ULg; Defechereux, Thierry ULg; Nguyen Dang, Delphine ULg et al

in Annales d'Endocrinologie (1997), 58(1), 65-74

Today, laparoscopy is for us the technique of choice for approaching presumed benign adrenal tumors. With regards to pheochromocytoma however, two major questions must be addressed. First, is it ... [more ▼]

Today, laparoscopy is for us the technique of choice for approaching presumed benign adrenal tumors. With regards to pheochromocytoma however, two major questions must be addressed. First, is it acceptable to resect potentially multifocal tumors with such a targeted approach? Second, can peroperative hemodynamic changes be anticipated and controlled by the anesthetist, taking into account the additional effects of pneumoperitoneum and catecholamine release on the cardiovascular system? The present prospective study attempts to answer these two questions. From November 1993 to November 1995 we operated on four women and two men, with ages ranging from 33 to 71 years (mean of 47) and a mean Body Mass Index of 25 kg/m2 (range 17-35). Four patients were assigned ASA (American Society of Anesthesiologists) physical status 2, one grade 1 and one grade 3. Comprehensive preoperative work-up, including a CT scan and an I131 MIBG Scan in all, a C11 Hydroxyephedrine PET Scan in 4 and a MRI in one patient, showed a solitary lesion in each case. There were four right-sided and two left-sided tumors, ranging from 30 to 60 mm in diameter. Laparoscopy was always performed transperitoneally. Systemic and pulmonary hemodynamics were thoroughly assessed. Epinephrin and norepinephrin concentrations were measured at the 10 key-time of surgery. Use of continuous intravenous infusion of nicardipine allowed tight control of hemodynamics despite impressive increases in circulating catecholamines. The mean operative time was 76 minutes (range 59-130). Blood loss was minimal. We observed neither mortality nor morbidity. Mean hospital stay ranged from 3 to 13 days (median = 3). All patients are normotensive without drug after a follow-up of 9 to 33 months. In conclusion, we think that laparoscopic removal of selected cases of pheochromocytoma may be performed safely from both the hemodynamical and oncological standpoints. [less ▲]

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See detailGenetic Structure Of A Lima Bean Base Collection Using Allozyme Markers
Maquet, A.; Bi, Iz.; Delvaux, M. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1997), 95(5-6),

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See detailEtude morphométrique du sabot et du petit sésamoïde du cheval
Gabriel, Annick ULg; Detilleux, J.; Jolly, S. et al

in Annales de Médecine Vétérinaire (1997), 147

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See detailProgramme EsQUIsE. Acquisition et interprétation de croquis d'architecture
Leclercq, Pierre ULg

in La lettre de l'IA (1997), 123

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See detailIntroduction
Delhalle, Nancy ULg

in Alternatives Théâtrales (1997), 55

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See detailChanging sensitivity to duration in human scalar timing: An experiment, a review, and some possible explanations
Ferrara, André ULg; Lejeune, Helga ULg; Wearden, J. H.

in Quarterly Journal of Experimental Psychology. B, Comparative & Physiological Psychology (1997), 50B

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See detailOrientation des objectifs et participation à des activités sportives
Ledent, Maryse; Telama, Risto; Cloes, Marc ULg et al

in Sport (1997), 159/160

Il existe une multitude de facteurs d'influence qui rendent la prévision d'une participation à l'activité sportive particulièrement délicate: influences biologiques et démographiques, psychologiques ... [more ▼]

Il existe une multitude de facteurs d'influence qui rendent la prévision d'une participation à l'activité sportive particulièrement délicate: influences biologiques et démographiques, psychologiques, sociales et environnementales. ... [less ▲]

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See detailCompte rendu de L. Couloubaritsis, J.-J. Wunenburger, La couleur, Bruxelles, 1993 (Recueil, 4)
Marganne, Marie-Hélène ULg

in Archives Internationales d'Histoire des Sciences (1997), 47

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See detailRelations entre les conditions d'habitat et la pathologie en production de viande bovine
Nicks, Baudouin ULg

in Aspects de la conception des bâtiments pour les bovins à viande (1997)

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See detailExpression of insulin-related peptides in the human thymus
Geenen, Vincent ULg; Lefebvre, Pierre ULg

in International Diabetes Monitor (1997), 9

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See detailDeux POHLIA méconnus d'Alsace: P.lutescens (Limpr.) Lindb. et P. lescuriana (Sull.) Andrews
Vanderpoorten, Alain ULg

in Bulletin de la Société d'Histoire Naturelle de Colmar (1997), 63

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See detailOxidation of allylselenides with the Sharpless AD-reagents
Krief, Alain; Colaux, Catherine ULg; Dumont, willy

in Tetrahedron Letters (1997), 38(18), 3315-3318

Allylselenides are efficiently oxidized by AD-mix reagents. Oxidation takes chemoselectively place on the selenium atom of allylselenides bearing a methylseleno or a phenylseleno moiety, but ... [more ▼]

Allylselenides are efficiently oxidized by AD-mix reagents. Oxidation takes chemoselectively place on the selenium atom of allylselenides bearing a methylseleno or a phenylseleno moiety, but chemoselectively occurs on the C,C double bond of the corresponding o-nitrophenyl derivatives. [less ▲]

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See detailPit-1 gene HinfI RFLP and growth traits in double-muscled Belgian Blue cattle
Renaville, Robert ULg; Gengler, Nicolas ULg; Parmentier, Isabelle et al

in Journal of Animal Science (1997), 75(1), 146

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See detailSurface Molecular Structure of Self-Assembled Alkanethiols Evidenced by UPS and Photoemission with Synchrotron Radiation
Duwez, Anne-Sophie ULg; Di Paolo, Stéphanie; Ghijsen, Jacques et al

in Journal of Physical Chemistry B (1997), 101

With the aim of investigating the configurational and conformational characteristics of monolayers of alkanethiols on gold by means of a photoemission experiment, we compare the valence data obtained from ... [more ▼]

With the aim of investigating the configurational and conformational characteristics of monolayers of alkanethiols on gold by means of a photoemission experiment, we compare the valence data obtained from these layers using synchrotron radiation and ultraviolet photoemission spectroscopy (UPS). The incident energy used for synchrotron radiation has been chosen very close to the Cooper minimum of the 5d levels of gold, in order to limit as much as possible interference from the substrate. The recorded spectra differ markedly from one sample to another, notwithstanding their closely related chemical nature. These variations are compared consistently with semiquantitative simulations on model clusters and found thereby to reflect specifically the influence of the connectivity and of specific interactions on the electronic structure of long hydrocarbon chains [less ▲]

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See detailHuman TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer
Jacquemin, Patrick; Martial, Joseph ULg; Davidson, Irwin

in Journal of Biological Chemistry (1997), 272(20), 12928-37

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in ... [more ▼]

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in skeletal and cardiac muscle, but the strongest expression is observed in the placenta and in placenta-derived JEG-3 choriocarcinoma cells. In correlation with its placental expression, we show that hTEF-5 binds to several functional enhansons of the human chorionic somatomammotropin (hCS)-B gene enhancer. We define a novel functional element in this enhancer comprising tandemly repeated sites to which hTEF-5 binds cooperatively. In the corresponding region of the hCS-A enhancer, which is known to be inactive, this element is inactivated by a naturally occurring single base mutation that disrupts hTEF-5 binding. We further show that the binding of the previously described placental protein f/chorionic somatomammotropin enhancer factor-1 to TEF-binding sites is disrupted by monoclonal antibodies directed against the TEA domain and that this factor is a proteolytic degradation product of the TEF factors. These results strongly suggest that hTEF-5 regulates the activity of the hCS-B gene enhancer. [less ▲]

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See detailSpinal ischaemia after surgery for abdominal infrarenal aortic aneurysm. Diagnosis with nuclear magnetic resonance.
Defraigne, Jean-Olivier ULg; OTTO, Bernard ULg; SakalihasanN, Natzi ULg et al

in Acta Chirurgica Belgica (1997), 97(5), 250-6

A 76-year-old man underwent surgery for an infrarenal aortic aneurysm reaching 6 cm in maximal transverse diameter. The aorta was crossclamped below the level of the renal arteries. A tube graft was ... [more ▼]

A 76-year-old man underwent surgery for an infrarenal aortic aneurysm reaching 6 cm in maximal transverse diameter. The aorta was crossclamped below the level of the renal arteries. A tube graft was interposed and tend between the infrarenal aorta and the aortic bifurcation. Due to leakage on the suture line two consecutive episodes of crossclamping for a total duration of 40 min. were required. No hypotension was noted during or after the procedure. After operation, the patient complained of difficulties to move both legs and neurologic examination demonstrated paraparesis, with mild sensory deficit. Faecal and urinary incontinences were also noted and urodynamic testing demonstrated sphincterovesical palsy. Nuclear magnetic resonance imaging detected an ischaemic zone in the spinal cord at the level of T11. Faecal incontinence and motor deficit partially resolved but no bladder function recovery was observed. Spinal ischaemia is a rare complication after abdominal aortic surgery. Several risk factors have been suggested which include level and duration of the aortic crossclamping, possible interruption of the spinal cord blood supply via the greater medullary artery (the so-called artery of Adamkiewicz), presence of intra- or postoperative episodes of hypotension, atheromatous embolization, underlying occlusive arteriosclerosis of spinal arteries, and respect or not of the hypogastric circulation. In our case, the duration of the crossclamping and interruption of the blood flow in lumbar arteries probably supplying the distal spinal cord were likely contributive factors. [less ▲]

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See detailObesity and nutrition. The Belgian Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Beckers, F. et al

in Obesity Research (1997)

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See detailColestasis asociada a ticlopidina
Diaz Fuenzalida, A.; VALDES SOCIN, Hernan Gonzalo ULg; Laudano, O. et al

in Gastroenterologia y Hepatologia (1997), 20(3), 128-30

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of ... [more ▼]

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of jaundice, choluria, and itching of one month of evolution. The patient had taken ticlopidine twice a day for 3 months up to one week prior to admission for peripheral arteriopathy. Biopsy was performed showing acinar cholestasis and portal inflammatory infiltrate compatible with cholestasis due to hypersensitivity. Ticlopidine was discontinued by the patient himself one week prior to admission. The drug was not readministered and the evolution of the clinical and biochemical parameters of cholestasis decreased. The patient was asymptomatic and laboratory data were normal 4 months later. [less ▲]

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See detailUtilisation de l'habitat par la sérotine commune Eptesicus serotinus en Lorraine belge
Kervyn, Thierry; Brasseur, Jasmine; Libois, Roland ULg

in Bulletin de la Société Neuchâteloise des Sciences Naturelles (1997), 120(2), 35-41

The radiotracking of 10 serotine bats during a period of 73 nights shows that the animals hunt mainly at forest edges and above meadows. The mean distance between the main diurnal roost and hunting ... [more ▼]

The radiotracking of 10 serotine bats during a period of 73 nights shows that the animals hunt mainly at forest edges and above meadows. The mean distance between the main diurnal roost and hunting grounds is 2.1 +/- 1.2 km (n = 24). Secondary diurnal roosts are used within a radius of 250 m of the main diurnal quarters. Nocturnal resting places are situated in beech forests (Fagus sylvatica) near feeding areas. The activity area (minumum area method) of radiotracked serotine bats, all originating from the same colony, stretches to 15.8 km². [less ▲]

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See detailRésultats à une enquête internationale en mathématiques
Monseur, Christian ULg

in Mathématiques & pédagogie (1997), 114

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See detailLuc et Jean-Pierre Dardenne. Vingt ans de travail en cinéma et vidéo (1976-1996)
Van Cauwenberge, Geneviève ULg; Bajomée, Danielle ULg; Delruelle, Edouard ULg et al

in Revue belge du cinéma (1997), 41(Hiver), 96

Historical and analytical overview of the Dardenne’s cinématographic and videographic work from 1976 to 1996, with an interview with Luc and Jean-Pierre Dardenne. A lot of issues about the survivor’s ... [more ▼]

Historical and analytical overview of the Dardenne’s cinématographic and videographic work from 1976 to 1996, with an interview with Luc and Jean-Pierre Dardenne. A lot of issues about the survivor’s memory, the history consciousness, the wounds of memory, the survivor’s speech ; the memory of the social struggle ; the derelction and the transformation of the society ; the résistance ; the videographic and filmic forms and patterns (landscape, face, water, reality) ; the theatrical space and the relations between theatre and cinéma. [less ▲]

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See detailTiming effect of combined radioimmunotherapy and radiotherapy on a human solid tumor in nude mice.
Coucke, Philippe ULg; Lin-Quan, Sun; Vogel, Charles-André et al

in Cancer Research (1997), 57

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were ... [more ▼]

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were evaluated separately. Then, 30 Gy RT (10 fractions over 12 days) were combined with three weekly Lv. injections of 200 g@Ci of 131I-labeled anti-carcino embryonic antigen monoclonal antibodies in four different treatment schedules. RIT was given either prior to, concurrently, Immediately after, or 2 weeks after RT administration. The longest regrowth delay (RD) of 105 days was observed in mice treated by concurrent administration of RT and lilT, whereas the RDs of RT and RIT alone were 34 and 20 days, respectively. The three sequential combination treatments produced sig nificantly shorter RDs ranging from 62 to 70 days. The tumor response represented by the minimal volume (MV) also showed that concurrent administration of RT and RIT gave the best result, with a mean MV of 4.5% as compared to MVs from 26 to 53% for the three sequential treatments. The results were confirmed In a second experiment, In which a RT of 40 Gy was combined with an identical lilT as above (three injections of 200 g&Ci of ‘31I-labeled monoclonal antibodies). At compa rable toxicity levels, the maximum tolerated RT or BIT alone gave shorter RDs and less tumor shrinkage compared to slinultaneous RT+RIT. These results may be useful for designing clinical protocols ofcombined RIT and RT. [less ▲]

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See detailEn mai élis qui te plaît
Durand, Pascal ULg

in Liège Université (1997), (été), 3

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See detailField observations of the spawning behaviour of European grayling
Darchambeau, François ULg; Poncin, Pascal ULg

in Journal of Fish Biology (1997), 51(5), 1066-1068

During observations of the River Ourthe, Belgium, 70 spawning attempts were recorded during the reproductive period of the European grayling. Thirty-six per sent of the spawning attempts proceeded to ... [more ▼]

During observations of the River Ourthe, Belgium, 70 spawning attempts were recorded during the reproductive period of the European grayling. Thirty-six per sent of the spawning attempts proceeded to completion, while interference by another male may explain some of the incomplete acts. Sneaking behaviour was observed and one spawning act included two males and one female. (C) 1997 The Fisheries Society of the British Isles. [less ▲]

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See detailSoil oribatid mite communities (Acari: Oribatida) from high Shaba (Zaïre) in relation to vegetation
Noti, M.-I.; André, H. M.; Dufrêne, Marc ULg

in Applied Soil Ecology (1997), 5(1), 81-96

Soil oribatid mite communities from three vegetation types (forest, woodland and savanna) are described in Luiswishi (high Shaba, Zaïre) and 151 species were recorded. Oribatid communities are organized ... [more ▼]

Soil oribatid mite communities from three vegetation types (forest, woodland and savanna) are described in Luiswishi (high Shaba, Zaïre) and 151 species were recorded. Oribatid communities are organized along a successional gradient which parallels the regressive sere defined by phytosociologists and going from the dense forest ("muhulu"), the local climax, to the savanna, passing through the woodland ("miombo"). Within this gradient, oribatid communities may vary depending on the habitat (presence of grass, high termitaria). The impact of seasons (dry vs. rainy season) is weak in the forest but drastic in savanna. The various soil oribatid communities are related to man's activities since the regressive sere results from repeated burnings and associated agricultural practices. [less ▲]

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See detailMemory kernels and effective Hamiltonians from time dependent methods. I. Predissociation with a curve crossing
Desouter, Michèle ULg; Liévin, Jacques

in Journal of Chemical Physics (1997), 107

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See detailDe différences en disparités : les effets d'un système éducatif 'non compréhensif'
Lafontaine, Dominique ULg

in Scientia Paedagogica Experimentalis (1997), XXXIV(2), 267-281

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique ... [more ▼]

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique, organisation en tronc commun ou en filières, présence ou non d'une carte scolaire) et différents indices de performance ou d'équité : performances moyennes en lecture à un test international comparatif, degré d'hétérogénéité des performances entre élèves, disparités de rendement selon l'établissement ou la filière fréquenté(e). Les résultats montrent que le redoublement, largement pratiqué en Communauté française de Belgique, ne débouche ni sur des meilleures performances, ni sur une réduction sensible des disparités entre élèves. L'absence de tronc commun et de sectorisation engendre en outre de fortes disparités selon la filière et selon l'établissement fréquenté. Le premier degré du secondaire de la Communauté française, organisé en système 'non compréhensif', semble ainsi de nature à amplifier plutôt qu'à corriger les inégalités entre élèves issus du primaire. [less ▲]

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See detailPolymorphous light eruption-like lesions on sun-protected injection sites of recombinant IFN-alpha-2b
Nikkels, Arjen ULg; Delwaide, Jean ULg; Letawe, C. et al

in Journal of Dermatological Treatment (1997), 8(4), 285

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See detailCompte rendu de A. ANGENENDT, Heilige und Reliquien, Munich, 1994
George, Philippe ULg

in Francia. 1, Mittelalter (1997)

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See detailDamping rates of hard momentum particles in a cold ultrarelativistic plasma
Vanderheyden, Benoît ULg; Ollitrault, J. Y.

in Physical Review. D : Particles and Fields (1997), 56(8), 5108-5122

We compute the damping rates of one-particle excitations in a cold ultrarelativistic plasma to leading order in the coupling constant e for three types of interaction: Yukawa coupling to a massless scalar ... [more ▼]

We compute the damping rates of one-particle excitations in a cold ultrarelativistic plasma to leading order in the coupling constant e for three types of interaction: Yukawa coupling to a massless scalar boson, QED, and QCD. Damping rates of charged particles in QED and QCD are of order e(3) mu, while the damping rates of other particles are of order e(4) mu or e(4) mu log(1/e). We find that the damping rate of an electron or of a quark is constant far from the Fermi surface, and decreases linearly with the excitation energy close to the Fermi surface. This unusual behavior is attributed to the long-range magnetic interactions. [less ▲]

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See detailIn vivo binding of [F-18]altanserin to rat brain 5HT(2) receptors: A film and electronic autoradiographic study
Biver, Françoise; Lotstra, Françoise; Monclus, M. et al

in Nuclear Medicine and Biology (1997), 24(4), 357-360

To further validate its use in positron emission tomography (PET), we studied the binding of [18F]altanserin, a specific 5HT2 radioligand, in the rat brain using in vivo autoradiography. Distribution of ... [more ▼]

To further validate its use in positron emission tomography (PET), we studied the binding of [18F]altanserin, a specific 5HT2 radioligand, in the rat brain using in vivo autoradiography. Distribution of [18F]altanserin binding was comparable to the in vitro mapping of 5HT2 receptors reported in the literature. Selective displacers were used to test the reversibility and the selectivity of this radioligand. Specific binding of [18F]altanserin in the rat frontal cortex was quantified by direct counting with an electronic imaging system and by quantification on digitalized autoradiograms. Close results of about 30 pmol/g were obtained with both methods. Our data confirmed that [18F]altanserin is a valid tracer for 5HT2 receptors binding studies. [less ▲]

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See detailPlaidoyer pour une expertise entièrement contradictoire en matière pénale
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailEtablissement d'un plan volontaire de contrôle de la rhinotrachéite infectieuse bovine en région wallonne de Belgique
De Wergifosse, Bertrand; Lemaire, Mylène; Pastoret, Paul-Pierre ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailAn introduction to ET-LOTOS for the description of time-sensitive systems
Léonard, Luc; Leduc, Guy ULg

in Computer Networks & ISDN Systems (1997), 29(3), 271-292

Enhanced Timed-LOTOS, called ET-LOTOS, is an extension of LOTOS allowing the modelling of time-sensitive systems (i.e. systems whose behaviour is influenced by the passing of time). It is the basis of the ... [more ▼]

Enhanced Timed-LOTOS, called ET-LOTOS, is an extension of LOTOS allowing the modelling of time-sensitive systems (i.e. systems whose behaviour is influenced by the passing of time). It is the basis of the timed extension of LOTOS currently developed by ISO (1995). The purpose of this paper is to present ET-LOTOS in a tutorial style and show its applicability. The detailed study of the formal semantics is addressed in another paper. A collection of small but realistic, examples illustrates a wide variety of time-sensitive protocol mechanisms. These examples are used to introduce and justify the extensions of our language. Finally, the basics of the formal semantics are given and a comparison is made with other timed formalisms. [less ▲]

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See detailThe spectrum of 67-kD laminin receptor expression in breast carcinoma progression.
Viacava, P.; Naccarato, A. G.; Collecchi, P. et al

in Journal of Pathology (The) (1997), 182(1), 36-44

Laminin is a glycoprotein of the basement membrane (BM), involved in a variety of normal and pathological cellular events including tumour invasion and metastasis. Cells bind laminin through different ... [more ▼]

Laminin is a glycoprotein of the basement membrane (BM), involved in a variety of normal and pathological cellular events including tumour invasion and metastasis. Cells bind laminin through different types of receptor. The 67-kD laminin receptor (67LR) is a cell-surface protein which binds laminin with high affinity. 67LR expression has been shown to increase in neoplastic cells, compared with normal tissues, and 67LR seems to play an important role during the first steps of neoplastic progression. In this study, 67LR expression was analysed during the morphological phases of breast cancer progression from normal tissue to invasive carcinoma. A total of 506 formalin-fixed, paraffin-embedded normal breast structures and lesions were stained by immunohistochemistry usign the MLuC5 monoclonal antibody, which is specific for 67LR. The results show that in normal breast and in any kind of breast lesion, myoepithelial and endothelial cells express 67LR. While 67LR is not seen in the epithelium of normal breast, cysts, adenosis, and benign tumours, it is expressed in the epithelial cells of several hyperplasias and carcinomas in situ, both ductal and lobular, as well as in all invasive carcinomas. The 67LR-positive cell subpopulation expands from hyperplastic lesions to invasive carcinoma, suggesting that 67LR could be related to the induction and progression of breast cancer. [less ▲]

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See detailLe dessaisissement du juge d'instruction
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (1997)

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See detailImaging the solar corona in the EUV
Delaboudiniere, J.-P.; Stern, R. A.; Maucherat, A. et al

in Advances in Space Research (1997), 20

The SOHO (SOlar and Heliospheric Observatory) satellite was launched on December 2nd 1995. After arriving at the Earth-Sun (L1) Lagrangian point on February 14th 1996, it began to continuously observe the ... [more ▼]

The SOHO (SOlar and Heliospheric Observatory) satellite was launched on December 2nd 1995. After arriving at the Earth-Sun (L1) Lagrangian point on February 14th 1996, it began to continuously observe the Sun. As one of the instruments onboard SOHO, the EIT (Extreme ultraviolet Imaging Telescope) images the Sun's corona in 4 EUV wavelengths. The He II filter at 304 AË images the chromosphere and the base of the transition region at a temperature of 5 - 8 x 10^4 K; the Fe IX-X filter at 171 AË images the corona at a temperature of ~ 1.3 x 10^6 K; the Fe XII filter at 195 AË images the quiet corona outside coronal holes at a temperature of ~ 1.6 x 10^6 K; and the Fe XV filter at 284 AË images active regions with a temperature of ~ 2.0 x 10^6 K. About 5000 images have been obtained up to the present. In this paper, we describe also some aspects of the telescope and the detector performance for application in the observations. Images and movies of all the wavelengths allow a look at different phenomena present in the Sun's corona, and in particular, magnetic field reconnection. [less ▲]

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See detailIn vivo study of enhancing factors for guided bone formation
Biewer, Bob; Van Heusden, Alain ULg; Rompen, Eric ULg

in Journal of Clinical Periodontology (1997), 11

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See detailGenetic Diversity In Lima Bean (Phaseolus Lunatus L) As Revealed By Rapd Markers
Fofana, B.; Vekemans, X.; Du Jardin, Patrick ULg et al

in Euphytica (1997), 95(2),

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See detailAerosol therapy in the equine species
Duvivier, Dominique Hannia; Votion, Dominique ULg; Vandenput, Sandrina ULg et al

in Veterinary Journal (1997), 154(3), 189-202

Inhalation therapy plays an increasing role in the management of equine respiratory disorders. This alternative to systematic treatment permits a high concentration of medication to act locally while ... [more ▼]

Inhalation therapy plays an increasing role in the management of equine respiratory disorders. This alternative to systematic treatment permits a high concentration of medication to act locally while minimizing side effects and residues. In human medicine, literature in this field is prolific and continuously renewed, whereas in veterinary medicine, applications of aerosol therapy are less extensive. This review considers the principles of action of the different types of devices used for inhalation, i.e., nebulization, metered-dose inhalation and dry powder inhalation, describes the technical and practical requirements for their use in the equine species and considers the advantages and disadvantages of each inhalation device. The pharmacological agents currently administered to horses by inhalation are also discussed. Perspectives of aerosol therapy in the equine species, including aerosols already used in human medicine and their potential applications for horses are described [less ▲]

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See detailFin du Millénaire - fin de l'Agriculture
Schirmer, Jacek; Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (1997), 33

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See detailRheinische Wortgeographie. Karten des Rheinischen Wörterbuchs und ihre computative Auswertung. Teil II
Möller, Robert ULg

in Rheinische Vierteljahrsblätter (1997), 61

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See detailComment j'explore ... un patient avec hypotension orthostatique.
Scheen, André ULg; De Fooz, Geoffroy; Marchand, Monique ULg

in Revue Médicale de Liège (1997), 52(2), 116-9

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See detailDensity-functional theory of polar insulators
Gonze, X.; Ghosez, Philippe ULg; Godby, R. W.

in Physical Review Letters (1997), 78(2), 294-297

We examine the density-functional theory of macroscopic insulators, obtained in the large-cluster limit or under periodic boundary conditions. For polar crystals, we find that the two procedures are not ... [more ▼]

We examine the density-functional theory of macroscopic insulators, obtained in the large-cluster limit or under periodic boundary conditions. For polar crystals, we find that the two procedures are not equivalent. In a large-cluster case, the exact exchange-correlation potential acquires a homogeneous ''electric field'' which is absent from the usual local approximations, and the Kohn-Sham electronic system becomes metallic. With periodic boundary conditions, such a field ist forbidden, and the polarization deduced from Kohn-Sham wave functions is incorrect even if the exact functional is used. [less ▲]

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See detailIgneous charnockites and related rocks from the Bjerkreim-Sogndal layered intrusion (Southwest Norway): a jotunite (hypersthene monzodiorite)-derived A-type granitoid suite
Duchesne, Jean-Clair ULg; Wilmart, Edith

in Journal of Petrology (1997), 38(3), 337-369

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and ... [more ▼]

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and geochemistry (major and trace elements) of 8 main rock types (88 samples) are considered. The rocks form a suite of K2O-rich alkali-calcic granitoids of A-type, deriving from jotunitic magma. Two trends of inferred liquids are distinguished: the main liquid line of descent which passes from jotunites through 2-pyroxene quartz mangerites to amphibole charnockites, the second one which encompasses olivine-bearing quartz mangerites and charnockites and is rooted into mangeritic liquids. Comparison with the Tellnes rock series reveals that contamination by leucogranitic material has taken place simultaneously with fractional crystallization in both BKSK trends. Zr, Rb, Cs, and Th are particularly sensitive to assimilation and the higher water content in BKSK. Zircon and apatite have saturated at the liquidus of quartz mangerite around 900°C, close to the FMQ buffer. The two-pyroxene quartz mangerites cannot have been equilibrated with the mangerite cumulates on which they rest. A major influx of magma took place when mangeritic cumulates were being deposited. It mingled and partly mixed with the resident contaminated magma. [less ▲]

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See detailPsychiatrie de liaison:regards sur une pratique de la psychologie médicale en hôpital général
Triffaux, Jean-Marc ULg

in Revue francaise de psychiatrie et de psychologie médicale (1997)

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See detailEvidence for enhanced inflammatory cell activity, ICAM-1 expression and eosinophil chemotactic activity in the sputum of asthmatics.
Louis, Renaud ULg; Shute, J.; Biaggi, S. et al

in American Journal of Respiratory & Critical Care Medicine (1997), 155(2), 466-472

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma ... [more ▼]

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects contained increased numbers of eosinophils and levels of eosinophil cationic protein (ECP) and mast cell tryptase. Eosinophil numbers, and ECP and histamine levels correlated with the degree of methacholine airways responsiveness, and ECP, tryptase, and histamine correlated with raised concentrations of albumin. Using the micro-Boyden chamber technique eosinophil chemotactic activity was identified only in the sputum from asthmatics. The correlation between the raised levels of total IgA, IL- 8/IgA complexes, and tryptase and the degree of sputum eosinophilia and ECP levels, suggests possible mechanisms for eosinophil chemotaxis and activation in asthma. Row cytometric analysis of sputum lymphocytes showed an increase in CD4+ T cells and T cells expressing intercellular adhesion molecule-1 (ICAM-1) in asthma which, together with the finding of raised levels of soluble ICAM-1 in the sputum, indicates upregulation of this adhesion molecule. Finally, the proportion of CD16+ natural killer (NK) cells was reduced in the sputum of asthmatics. These observations highlight the importance of the airway inflammation in causing asthma and further confirm the usefulness of sputum induction as a tool in asthma research. [less ▲]

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See detailDifferential expression of galectin 3 and galectin 1 in colorectal cancer progression.
Sanjuan, X.; Fernandez, P. L.; Castells, A. et al

in Gastroenterology (1997), 113(6), 1906-15

BACKGROUND & AIMS: Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and ... [more ▼]

BACKGROUND & AIMS: Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS: Galectin 3 expression was examined immunohistochemically in 39 samples of normal mucosae, 25 adenomas, 87 carcinomas, and 39 lymph node metastases. Galectin 1 was analyzed in 25 samples of mucosae, 15 adenomas, 25 carcinomas, and 11 metastases. Western blot analysis was also performed. RESULTS: All normal mucosae showed strong nuclear galectin 3 expression, which was down-regulated in the neoplastic progression, because only 60% of adenomas, 48% of carcinomas, and 44% of metastases were strongly positive (P < 0.0001). Cytoplasmic expression was down-regulated in adenomas (16%) but increased again in carcinomas (64%) (P < 0.0001). Galectin 1 expression was mainly detected in stromal cells and correlated with tumor progression from normal mucosae to adenomas and carcinomas (P < 0.0001). CONCLUSIONS: Galectin 3 expression is down-regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Galectin 1 in colorectal mucosa is predominantly a stromal product whose overexpression is associated with the neoplastic progression of colorectal cancer. [less ▲]

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See detailZastosowanie ultrasonografii w diagnostyce klinicznej ukladu rozrodczego u bydla
Gajewski, Z.; Hanzen, Christian ULg; Thun, R. et al

in Nowa Weterynaria (1997)

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See detailComplications hepatiques de la chimiotherapie. De la cytolyse banale a la maladie veino-occlusive du foie.
Baron, Frédéric ULg; Beguin, Yves ULg

in Revue Médicale de Liège (1997), 52(2), 93-7

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See detailEnhancement of Tamoxifen-Induced E-Cadherin Function by Ca2+ Channel Antagonists in Human Breast Cancer Mcf7/6 Cells
Charlier, Corinne ULg; Bruyneel, E.; Lechanteur, Chantal ULg et al

in European Journal of Pharmacology (1996), 317(2-3), 413-6

Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized. Tamoxifen was recently shown to ... [more ▼]

Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized. Tamoxifen was recently shown to restore the E-cadherin function of human breast cancer MCF7/6 cells and to suppress their invasive phenotype. Because tamoxifen interacts with targets implicated in Ca2+ homeostasis, we explored the possibility that the restoration of E-cadherin function in MCF7/6 cells induced by this drug could be affected by Ca2+ modulators. Two different Ca2+ channel antagonists (verapamil and nifedipine) potentiated the effect of tamoxifen on E-cadherin function, as evaluated with a fast cell aggregation assay. These molecules decreased the tamoxifen concentration needed to restore the E-cadherin function from 10(-6) M to 10(-7) M. When incubated with a Ca2+ channel agonist, Bay K8644 (methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoro-methylphenyl)- pyridine-5-carboxylate), the effect of tamoxifen on E-cadherin function was completely abolished. These results demonstrate that the restoration of the E-cadherin function induced by tamoxifen depends, at least in part, on a Ca2+ pathway, and support the evidence of an effect of tamoxifen on Ca(2+)-dependent mechanisms. Our data also suggest that Ca2+ channel modulators could make it possible to decrease the dose of tamoxifen administered to patients without reducing the therapeutic effects. [less ▲]

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See detailPoly[alkyl methacrylate-b-butadiene-b-alkyl methacrylate] triblock copolymers : synthesis, morphology, and mechanical properties at high temperatures
Yu, Jian Ming; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1996), 29(26), 8362-8370

Block copolymers of the ABA type, where B is polybutadiene (PBD) and A is poly(ethyl methacrylate) (PEMA), poly(tert-butyl methacrylate) (P-t-BMA), poly(methyl methacrylate) (PMMA), or poly(isobornyl ... [more ▼]

Block copolymers of the ABA type, where B is polybutadiene (PBD) and A is poly(ethyl methacrylate) (PEMA), poly(tert-butyl methacrylate) (P-t-BMA), poly(methyl methacrylate) (PMMA), or poly(isobornyl methacrylate) (PIBMA), have been successfully synthesized by sequential anionic polymerization of butadiene and methacrylates with the diadduct of tert-butyllithium to m-diisopropenylbenzene as a difunctional initiator. Block copolymers of a narrow molecular weight distribution (1.10) have been analyzed by differential scanning calorimetry, transmission electron microscopy, and dynamic mechanical analysis. These materials are phase-separated and have high mechanical performances. Special attention has been paid to the service temperature of these thermoplastic elastomers in comparison with a styrene−butadiene−styrene (SBS) triblock copolymer. The upper service temperature (UST) has been estimated from the temperature dependence of the tensile properties in the 25−150 °C range and found to change with the outer blocks. Polystyrene (Tg = 100°C) is at the origin of the lower UST, which is however comparable to PEMA (Tg = 90 °C) and P-t-BMA (Tg = 116 °C) containing triblock copolymers of similar molecular weight and composition. PMMA (Tg = 132 °C) outer blocks increase the UST of the triblocks, which is further increased by hydrogenation of the PBD midblock. The higher UST has been found for a PIBMA (Tg = 202 °C)-containing triblock copolymer that shows an ultimate tensile strength higher than 2 MPa at 150 °C. [less ▲]

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See detailTriblock copolymer based thermoreversible gels. 3. Effect of stereocomplexation with iPMMA
Yu, Jian Ming; Jérôme, Robert ULg

in Macromolecules (1996), 29(26), 8371-9378

Thermoreversible gelation of syndiotactic poly(methyl methacrylate) (sPMMA)−polybutadiene (PBD)−sPMMA, triblock copolymers in o-xylene has been studied in the presence of isotactic PMMA (iPMMA) in a large ... [more ▼]

Thermoreversible gelation of syndiotactic poly(methyl methacrylate) (sPMMA)−polybutadiene (PBD)−sPMMA, triblock copolymers in o-xylene has been studied in the presence of isotactic PMMA (iPMMA) in a large range of syndio/iso mixing ratio (s/i). Differential scanning calorimetry (DSC) shows that two types of association contribute to the gel formation, i.e., the self-aggregation of the sPMMA outer blocks and the stereocomplexation of the sPMMA outer blocks with iPMMA. At low iPMMA contents (s/i = 30/1), self-association of the outer blocks accounts for the gelation process, although stereocomplexation occurs. Stereocomplexation becomes the dominant gelation mechanism at a high enough iPMMA content (s/i = 2/1). Thus, gelation is observed at a copolymer concentration as low as 1 wt %. The time dependence of the storage (G‘) and loss (G‘‘) moduli has been measured in the 0.08−1Hz frequency range in order to probe the gelation process. At the gel point, where the loss angle (tan δc = G‘‘/G‘) is independent of the probing frequency, the sample fits in the typical power law G‘(ω) G‘‘(ω) ωΔ. While the gelation time is greatly influenced by the s/i mixing ratio, the scaling exponent Δ is essentially constant in the range of 0.70−0.75. The Δ value agrees with theoretical predictions as well as with experimental values reported for some chemical gels but it is different from the experimental values reported for most physical gels. The Δ value is also independent of the PBD microstructure and it also holds for sPMMA-polystyrene (PS)−PBD−PS−sPMMA (MSBSM) pentablock copolymers. Therefore, the value of Δ appears to be a typical exponent for thermoplastic gels based on triblock copolymers of the ABA type in o-xylene. [less ▲]

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See detailInterleukin-1 Beta Induces Nuclear Factor Kappa B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates
Bonizzi, Giuseppina; Dejardin, Emmanuel ULg; Piret, Bernard et al

in European Journal of Biochemistry (1996), 242(3), 544-9

A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B ... [more ▼]

A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) in various cell types. Several studies have indicated that NF-kappa B activation depends strictly on the production of reactive oxygen intermediates. In this report, we first demonstrated that IL-1 beta is a potent activator of NF-kappa B in various epithelial transformed cell lines (OVCAR-3, SKOV-3, MCF7 A/Z). In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105. We showed that IL-1 beta-mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2. Our study demonstrated that several signaling pathways lead to the activation of NF-kappa B, following IL-1 beta treatment in different cell types. [less ▲]

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See detailIdentification of the active gene coding for the metastasis-associated 37LRP/p40 multifunctional protein.
Clausse, Nathalie; Jackers, Pascale ULg; Jares, P. et al

in DNA & Cell Biology (1996), 15(12), 1009-23

A 37LRP/p40 polypeptide is of major interest because it is consistently up-regulated in cancer cells in correlation with their invasive and metastatic phenotype. Furthermore, this polypeptide presents ... [more ▼]

A 37LRP/p40 polypeptide is of major interest because it is consistently up-regulated in cancer cells in correlation with their invasive and metastatic phenotype. Furthermore, this polypeptide presents intriguing multifunctional properties because it has been characterized as the precursor of the metastasis-associated 67-kD laminin receptor (67LR) and as a cytoplasmic ribosomal-associated protein. The isolation of the 37LRP/p40 gene is a prerequisite for identifying the molecular mechanisms responsible for the constant up-regulation of the 67LR expression in cancer cells. To date, the active 37LRP/p40 gene has never been identified in any species due to the existence of multiple pseudogenes in most vertebrates genomes. In this study, we report for the first time the gene structure and potential regulatory sequences of the 37 LRP/p40 gene. The chicken genome was selected to undergo this characterization because it is the only known vertebrate that bears a single 37 LRP/p40 gene copy. The 37 LRP/p40 active gene is composed of 7 exons and 6 introns and bears features characteristic of a ribosomal protein gene. It does not bear a classical TATA box and it exhibits several transcription initiation sites as demonstrated by RNase protection assay and primer extension. Analysis of potential regulatory regions suggests that gene expression is driven not only by the 5' genomic region but also by the 5' untranslated and intron 1 sequences. On the basis of gene structure and extensive protein evolutionary study, we found that the carboxyterminal domain of the protein is a conserved lock-and-key structure/function domain that could be involved in the biosynthesis of the higher-molecular-weight 67-kD laminin receptor in vertebrates, whereas the central core of the protein would be responsible for the ribosome associated function. The first identification of the active 37LRP/p40 gene presented in this study is a critical step toward the isolation of the corresponding human gene and the understanding of the molecular mechanisms involved in the up-regulation of its expression during tumor invasion and metastasis. [less ▲]

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See detailReduction in Requirements for Allogeneic Blood Products: Pharmacologic Methods
Janssens, Marc ULg; Hartstein, Gary ULg; David, Jean-Louis ULg

in Annals of Thoracic Surgery (1996), 62(6), 1944-50

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic ... [more ▼]

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic antifibrinolytics. METHODS: A review of the literature was carried out to help the reader define the indications of these drugs during cardiopulmonary bypass operations, highlight the questions that remain concerning their indications and modes of action, and suggest future studies to answer these remaining questions. RESULTS: Prostacyclin reduces platelet trauma induced by extracorporeal circulation but does not effectively reduce postoperative bleeding and transfusion requirements. Desmopressin acts as a "glue," improving platelet adhesion, and may be effective when postoperative bleeding is excessive, but its routine use in cardiac operations cannot be recommended. Natural and synthetic antifibrinolytics inhibit plasmin and plasmin-induced platelet dysfunction. These agents have been shown to decrease bleeding and the need for allogeneic transfusions after open heart operations. However, with antifibrinolytic drugs, the risk of thromboembolic phenomena cannot be neglected. With aprotinin, this risk appears to be minimal when the drug is used at concentrations high enough to inhibit plasma kallikrein also. CONCLUSIONS: Prophylactic antifibrinolytics are efficacious, but their routine use remains controversial, both for economic reasons and for fear of thromboembolic complications. [less ▲]

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See detailAnionic polymerization of various methacrylates initiated with LiCl-complexed sBuLi
Antoun, S.; Wang, Jin-Shan; Jérôme, Robert ULg et al

in Polymer (1996), 37(25), 5755-5759

A simple alkyl lithium initiator (sBuLi) complexed with LiCl (10 molar equiv.) has been used to initiate the anionic polymerization of various methacrylic monomers, i.e. methyl methacrylate (MMA), tert ... [more ▼]

A simple alkyl lithium initiator (sBuLi) complexed with LiCl (10 molar equiv.) has been used to initiate the anionic polymerization of various methacrylic monomers, i.e. methyl methacrylate (MMA), tert-butyl methacrylate (tBuMA), glycidyl methacrylate (GMA), and dimethyl amino ethyl methacrylate (DMAEMA) in tetrahydrofuran at -78°C. Only the homopolymerization of tBuMA proceeds in a living manner, as evidenced by both the linear plot of experimental molecular weight (Mnexp) vs theoretical ones (Mncal,) (slope % 0.93) and monomer resumption experiments. However, three types of block copolymers, i.e. PtBuMA-b-PMMA, PtBuMA-b-PGMA, PtBuMA-b-PDMAEMA, have been successfully synthesized with a predictable molecular weight, and narrow molecular weight distribution. [less ▲]

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See detailTnp-470 (Agm-1470): Mechanisms of Action and Early Clinical Development
Castronovo, Vincenzo ULg; Belotti, D.

in European Journal of Cancer (1996), 32A(14), 2520-7

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See detailLa CEI entre mythes et réalités
Bachkatov, Nina ULg

in Monde Diplomatique (Le) : Journal des Cercles Diplomatiques et des Grandes Organisations Internationales (1996)

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See detailStaging of the Mediastinum: Value of Positron Emission Tomography Imaging in Non-Small Cell Lung Cancer
Bury, Thierry ULg; Paulus, P.; Dowlati, A. et al

in European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology (1996), 9(12), 2560-4

Recent studies have shown limitations of morphological imaging in staging mediastinal lymph node involvement in lung cancer. In contrast to computed tomography (CT), which depends primarily on anatomical ... [more ▼]

Recent studies have shown limitations of morphological imaging in staging mediastinal lymph node involvement in lung cancer. In contrast to computed tomography (CT), which depends primarily on anatomical imaging features, positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) depends mainly on the metabolic characteristics of a tissue for the diagnosis of disease. We have performed a prospective study comparing FDG-PET and CT of the thorax in the presurgical assessment of the mediastinum in 50 patients with newly diagnosed non-small cell lung cancer (NSCLC). CT and PET scans were interpreted separately, and results were compared to pathological staging obtained during thoracotomy. Hilar or mediastinal lymph node involvement was present in 58%. In staging for lymph node involvement, CT had a sensitivity of 72% and specificity of 81%, whereas PET had a sensitivity and specificity of 90% and 86%, respectively. When the PET study was compared to histological results, there were four cases showing more advanced mediastinal involvement with PET and four cases showing less involvement with PET. From our preliminary results, we conclude that positron emission tomography with 18-fluorodeoxyglucose is significantly more accurate than computed tomography in the mediastinal staging of non-small cell lung cancer. [less ▲]

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See detailOncological Applications of Positron Emission Tomography with Fluorine-18 Fluorodeoxyglucose
Rigo, Pierre ULg; Paulus, Patrick; Kaschten, Bruno et al

in European Journal of Nuclear Medicine (1996), 23(12), 1641-74

Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical ... [more ▼]

Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications at different stages of diagnosis, and for staging and follow-up. This review first considers the biological characteristics of FDG and then discusses methodological considerations regarding its use. Clinical indications are considered, and the results achieved in respect of various organs and tumour types are reviewed in depth. The review concludes with a brief consideration of the ways in which clinical PET might be improved. [less ▲]

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See detailScreening and characterization of specific anti-lipopolysaccharide antibodies in Belgian blood donors by enzyme-linked immunosorbent assays
Nys, Monique ULg; Laub, R.; Damas, Pierre ULg et al

in European Journal of Clinical Investigation (1996), 26(12), 1134-1142

The goal of this project was to find and collect high concentrations of endotoxin-specific antibodies for therapeutic IgG- or IgM-enriched preparations. Various enzyme-linked immunosorbent assays (ELISAs ... [more ▼]

The goal of this project was to find and collect high concentrations of endotoxin-specific antibodies for therapeutic IgG- or IgM-enriched preparations. Various enzyme-linked immunosorbent assays (ELISAs) were developed to perform longitudinal studies of the serological response to a large panel of smooth and rough purified lipopolysaccharide (LPS) extracts in a population of healthy blood donors. To accomplish this, 1612 human serum samples from volunteer blood donors collected by seven different blood banks in Belgium were screened and specific IgM and IgG activities were measured. Approximately 17% of the donors had anti-LPS concentrations higher than 40 mg L-1. Of these, 10.9% had anti-smooth LPS antibodies, 3.7% had anti-rough LPS antibodies and 2.8% were found to be positive towards both types of LPS. The mean anti-LPS antibody concentration was 8 mg L-1 for rough LPS and 14 mg L-1 for smooth LPS. Age- and sex-related distributions of the activities indicated that the greatest prevalence of high anti-LPS concentration was in women aged 40-49 years and in men older than 60 years. Differential absorption experiments showed that the pooled serum of selected blood donors contained a mixture of specific and cross-reacting antibodies. We detected predominantly anti-LPS activities due to the IgG1 and IgG2 subclasses. The range of specificities to different LPS was increased by the pooling of selected sera. It was concluded that pools of naturally occurring specific anti-LPS immunoglobulin antibodies may be obtained in Belgium by screening blood donors using ELISAs that we have developed. [less ▲]

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See detailMicrostructure development in isothermally melt-textured 123-211 composite materials
Auguste, F.; Rulmont, André ULg; Vandewalle, Nicolas ULg et al

in Journal of Low Temperature Physics (1996), 105(5-6), 1439-1444

Microstructures of isothermally melt-textured 123-211 composite materials have been examined during the solidification process from quenched specimens. The distribution of 211 particles, the ... [more ▼]

Microstructures of isothermally melt-textured 123-211 composite materials have been examined during the solidification process from quenched specimens. The distribution of 211 particles, the superconducting 123 grain boundary and the solid-liquid interface features are emphasized. The quality of the materials has been investigated by thermopower and thermal conductivity measurements. A seeded-melt texturing technique has been also tested in order to grow large single-domain of DyBa2Cu3O7-y. The chosen seed was a Dy2O3 single crystal. [less ▲]

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See detailDo Sex Differences in the Brain Explain Sex Differences in the Hormonal Induction of Reproductive Behavior? What 25 Years of Research on the Japanese Quail Tells Us
Balthazart, Jacques ULg; Tlemcani, O.; Ball, G. F.

in Hormones & Behavior (1996), 30(4), 627-61

Early workers interested in the mechanisms mediating sex differences in morphology and behavior assumed that differences in behavior that are commonly observed between males and females result from the ... [more ▼]

Early workers interested in the mechanisms mediating sex differences in morphology and behavior assumed that differences in behavior that are commonly observed between males and females result from the sex specificity of androgens and estrogens. [less ▲]

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See detailGliomatosis Cerebri: Clinical, Radiological and Pathological Report of a Case with a Stroke-Like Onset
Schoenen, Jean ULg; de Leval, L.; Reznik, M.

in Acta Neurologica Belgica (1996), 96(4), 294-300

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and ... [more ▼]

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and both CT scan and MRI irregular white matter lesion suggesting a leucoencephalopathy. His neurological deficit regressed, and he was discharged after 2 weeks. He was readmitted 6 months later because of mental confusion. MRI revealed diffuse white matter lesions extending up to the frontal lobes, these were hyperintense on T2 weighted images and suggested the diagnosis of gliomatosis cerebri (GC). The patient became progressively comatose and died 6 weeks later. At autopsy the brain looked diffusely swollen with irregular greyish areas of the white matter of both centrum ovale and brain stem. On microscopic examination the cerebrum and brain stem were diffusely and asymmetrically infiltrated by numerous neoplastic glial cells without angiogenesis or disruption of architectonic boundaries. There were no mitoses nor necrosis. Many tumour cells were GFAP- and S100-positive. A high proportion of cells contained the leucocyte antigen Leu-7. This case of gliomatosis cerebri is compared to the 9 published cases of GC with an initial focal neurological deficit and to the 19 publications reporting MRI results. The controversial nosological boundaries and etiopathogenetic hypotheses of this peculiar neoplastic disease are discussed. [less ▲]

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See detailAdaptation de la méthodologie des langues étrangères aux styles d'apprentissage des élèves : un nouveau miroir aux alouettes ?
Simons, Germain ULg

in Etudes et Travaux (1996), (1), 19-38

Selon certains spécialistes de l'apprentissage d'une langue étrangère, le style d'apprentissage d'un individu fonctionne comme un "filtre à input" et exerce, de ce fait, une influence considérable sur le ... [more ▼]

Selon certains spécialistes de l'apprentissage d'une langue étrangère, le style d'apprentissage d'un individu fonctionne comme un "filtre à input" et exerce, de ce fait, une influence considérable sur le processus d'apprentissage de la langue étrangère et sur le niveau de performance atteint par les différents types d'apprenants. Cette conception des styles d'apprentissage conduit naturellement à supposer que l'enseignement optimal d'une langue étrangère est celui dont la méthodologie est en adéquation avec le style d'apprentissage des élèves. Selon G. Simons, il convient d'aborder ce type de recherche avec la plus grande prudence si on ne veut pas qu'elle devienne un miroir aux alouettes, un de plus. Pour éviter ce piège, G. Simons analyse quelques problèmes sous-jacents à ce domaine de recherche et tente d'y apporter des solutions. [less ▲]

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See detailTreatment of Excessive Mediastinal Bleeding after Cardiopulmonary Bypass
Hartstein, Gary ULg; Janssens, Marc ULg

in Annals of Thoracic Surgery (1996), 62(6), 1951-4

BACKGROUND: Excessive mediastinal bleeding after cardiopulmonary bypass is one of the most frequently reported complications of cardiac operations. Appropriate treatment requires a rapid and effective ... [more ▼]

BACKGROUND: Excessive mediastinal bleeding after cardiopulmonary bypass is one of the most frequently reported complications of cardiac operations. Appropriate treatment requires a rapid and effective diagnostic work-up, based on the knowledge of the pathophysiology induced by cardiopulmonary bypass. METHODS: Possible causes, diagnostic methods available, and therapeutic approaches are reviewed in the light of the literature published on excessive bleeding after cardiac operations. RESULTS: When bleeding is massive (> 250 to 300 mL/h for the first 2 hours, > 150 mL/h thereafter), immediate surgical reexploration is mandatory. When bleeding is less important (50 to 150 mL/h), the decision to reoperate should be based on the presence of hemodynamic compromise or a suspected surgical cause. Otherwise, coagulation testing should allow the correction of hemostatic defects as appropriate with protamine, platelet concentrates, fresh frozen plasma, desmopressin, or antifibrinolytics. Hypothermia and hypotension should be corrected and a trial of positive end-expiratory pressure may be considered if diffuse mediastinal oozing (especially from the bed of the mammary artery) is suspected. CONCLUSIONS: A protocol is suggested to guide treatment, taking into account the rapidity of blood loss and the suspected underlying cause. [less ▲]

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See detailBeta-Carbolines Induce Apoptotic Death of Cerebellar Granule Neurones in Culture
Malgrange, Brigitte ULg; Rigo, Jean-Marie ULg; Coucke, Paul et al

in Neuroreport (1996), 7(18), 3041-5

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n ... [more ▼]

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n-methyl-beta-carboline-3-carboxamide, which are negative allosteric modulators of the GABAA receptor acting at the benzodiazepine site, are neurotoxic for cerebellar granule neurones in culture. The beta-carboline-induced neuronal death is apoptotic since DNA internucleosomal fragmentation was induced and the neurotoxicity could be prevented by inhibitors of mRNA or protein synthesis. As GABA and benzodiazepine ligands (diazepam and Ro 15-1788) protect cerebellar granule cells against beta-carboline-induced toxicity, these data raise the possibility that the interaction between the beta-carbolines and the GABAA receptor is the triggering event leading to neuronal apoptosis. [less ▲]

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See detailGrowth of Cayley and diluted Cayley trees with two kinds of entities
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Journal of Physics : A Mathematical & General (1996), 29(22), 7089-7104

A kinetic growth model derived from the magnetic Eden model is introduced in order to simulate the growth of hierarchical structures, such as Cayley trees. We only consider the case where two kinds of ... [more ▼]

A kinetic growth model derived from the magnetic Eden model is introduced in order to simulate the growth of hierarchical structures, such as Cayley trees. We only consider the case where two kinds of entities are competing with each other can be further subjected to an external field. The very relevant case in which both kinds of entities have different coordination numbers is introduced here for the first time, and is called the diluted Cayley tree. Physical and geometrical properties of the finite and infinite trees are exactly found and simulated. Finite-size effects are emphasized and illustrated on the global or local magnetization and on the chemical activity. Asymptotic limits are given in each case. The generated patterns can be related to a correlated percolation problem briefly discussed in the appendix. [less ▲]

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See detailDecrease of Plasma Vitamin E (Alpha-Tocopherol) Levels in Patients with Abdominal Aortic Aneurysm
Sakalihasan, Natzi ULg; Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg et al

in Annals of the New York Academy of Sciences (1996), 800

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See detailCytokine Production by Human Thymic Epithelial Cells: Control by the Immune Recognition of the Neurohypophysial Self-Antigen
Martens, Henri ULg; Malgrange, Brigitte ULg; Robert, F. et al

in Regulatory Peptides (1996), 67(1), 39-45

Oxytocin (OT) has been shown to be the dominant peptide of the neurohypophysial family expressed by thymic epithelial and nurse cells (TEC/TNC) in various species. Thymic OT is not secreted but, after ... [more ▼]

Oxytocin (OT) has been shown to be the dominant peptide of the neurohypophysial family expressed by thymic epithelial and nurse cells (TEC/TNC) in various species. Thymic OT is not secreted but, after translocation of a hybrid neurophysin/MHC class I protein, is integrated within the plasma membrane of TEC, thus allowing its presentation to pre-T cells. In order to further demonstrate that thymic OT behaves like a membrane antigen, we assessed the effect of mAbs to OT on cytokine productions by cultures enriched in human TEC. 75-85% pure TEC cultures were prepared from human thymic fragments. Using immunofluorescence and confocal microscopy, ir-OT, ir-interleukin-1 beta (IL-1 beta), ir-interleukin-6 (IL-6) and ir-leukemia inhibitory factor (LIF) could be detected in these TEC cultures. ir-OT was restricted to TEC, while some ir-IL-6 and ir-LIF were also seen in occasional fibroblasts. In basal conditions, ir-IL-6 and ir-LIF (but not ir-OT and ir-IL-1 beta) were detected in the supernatants of human TEC cultures. MAbs to OT induced a marked increase of ir-IL-6 and ir-LIF secretion in TEC cultures. No significant effect was observed using mAbs against vasopressin, mouse immunoglobulins, or control ascitic fluid controls. These data show that OT is fully processed and recognized by specific mAbs at the outer surface of TEC plasma membrane. They further support that thymic OT behaves as the self-antigen of the neurohypophysial family. [less ▲]

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See detailTrypsin and Trypsinogen from an Antarctic Fish: Molecular Basis of Cold Adaptation
Genicot, S.; Rentier-Delrue, Françoise ULg; Edwards, D. et al

in Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology (1996), 1298(1), 45-57

Trypsin from Antarctic fish Paranotothenia magellanica displays molecular and kinetic properties typical of enzymes produced by psychrophilic organisms. The enzyme has a high catalytic efficiency at low ... [more ▼]

Trypsin from Antarctic fish Paranotothenia magellanica displays molecular and kinetic properties typical of enzymes produced by psychrophilic organisms. The enzyme has a high catalytic efficiency at low and moderate temperatures and is rapidly inactivated at temperatures higher than 30 degrees C. The nucleotide sequence was determined after mRNA extraction and cDNA synthesis. The cDNA encodes a pretrypsinogen which includes a seven residue activation peptide containing only three acidic residues preceeding the 222 amino-acid mature enzyme. A three-dimensional model of the enzyme was built. Structural parameters possibly involved in the adaptation to cold have been derived from comparison with the three-dimensional structure of the bovine enzyme. Among them are the lack of Tyr-151 in the substrate binding pocket, an overall decrease in the number of salt bridges and hydrophobicity and the increase in the surface hydrophilicity. [less ▲]

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See detailEvidence of involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
Johnson, Robert; Kovvali, G.; Guzder, Sami et al

in Journal of Biological Chemistry (1996), 271(45), 27897-90

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See detailProtein Kinase- and Staurosporine-Dependent Induction of Neurite Outgrowth and Plasminogen Activator Activity in Pc12 Cells
Leprince, Pierre ULg; Bonvoisin, Catherine ULg; Rogister, Bernard ULg et al

in Biochemical Pharmacology (1996), 52(9), 1399-405

We analysed how interactions between protein kinase-dependent intracellular signalling pathways were implicated in the control of the production of tissue-type plasminogen activator (tPA) and the ... [more ▼]

We analysed how interactions between protein kinase-dependent intracellular signalling pathways were implicated in the control of the production of tissue-type plasminogen activator (tPA) and the generation of neurite outgrowth by PC12 cells. To that aim, cells were treated with agents that interact with the trk receptor and with protein kinases A and C. Nerve growth factor induced only the formation of large neurites. The release of the protease and the production of short neurite outgrowth were found to be protein-kinase-A-dependent events that could be enhanced by simultaneous activation of protein kinase C with phorbol ester. At high concentration, staurosporine, a nonselective inhibitor of protein kinases, induced the production of short neurites and mimicked the protein-kinase-A-dependent effect on tPA release. Such a response was not observed with K-252a, an analogue of staurosporine devoid of neurite-outgrowth-promoting activity. The responses to protein kinase A stimulation and the addition of staurosporine, although similar, seemed to occur through an activation of distinct, yet interacting, signalling pathways. In conclusion, tPA release and large neurite outgrowth from PC12 cells are controlled by parallel, albeit interacting, pathways, suggesting that these two potentially antagonistic events in PC12 cell differentiation can be modulated in a concerted way or independently of each other, depending on the activity of several protein kinases. [less ▲]

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See detailSynthesis and properties of poly[isobornyl methacrylate (IBMA)-b-butadiene (BD)-b-IBMA] copolymers : new thermoplastic elastomers of a large service temperature range
Yu, Jian Ming; Dubois, Philippe ULg; Jérôme, Robert ULg

in Macromolecules (1996), 29(16), 7316-7332

Anionic polymerization of isobornyl methacrylate (IBMA) has been studied in THF and toluene in a temperature range from −78 to +40 °C by using (1,1-diphenyl-3,3-dimethylbutyl)lithium (DDBLi) as an ... [more ▼]

Anionic polymerization of isobornyl methacrylate (IBMA) has been studied in THF and toluene in a temperature range from −78 to +40 °C by using (1,1-diphenyl-3,3-dimethylbutyl)lithium (DDBLi) as an initiator in the presence of LiCl or not. Effect of solvent and polymerization temperature on tacticity has been studied. The reactivity of IBMA is comparable to tert-butyl methacrylate (tBMA), and polymers of a very narrow molecular weight distribution (<1.10) have been synthesized at room temperature, in THF, in the presence of LiCl. The Tg of PIBMA is found to vary from 170 to 206 °C with chain tacticity. Poly(isobornyl methacrylate) (PIBMA)−polybutadiene (PBD)−PIBMA triblock copolymers have been synthesized by using the m-diisopropenylbenzene (m-DIB)/tert-butyllithium (t-BuLi) diadduct as an initiator. The PBD midblock has been prepared in a cyclohexane/diethyl ether (100/6, v/v) mixture at room temperature. THF has been added [cyclohexane/diethyl ether/THF (100/6/100, v/v/v)] before the IBMA polymerization takes place at either −78 or +25 °C. Triblock copolymers of a very narrow molecular weight distribution (1.10) have been synthesized even at 25 °C, and no gel formation has been observed. These new triblock copolymers exhibit high tensile strength (30 MPa), high ultimate elongation (1000%), and high upper service temperature (160 °C). [less ▲]

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See detailNt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro
Malgrange, Brigitte ULg; Lefebvre, P. P.; Martin, Didier ULg et al

in Neuroreport (1996), 7(15-17), 2495-9

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted ... [more ▼]

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing. [less ▲]

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See detailA method to optimize intermediate-passband photometric systems.
Royer, P.; Manfroid, Jean ULg

in Astronomy and Astrophysics. Supplement Series (1996), 119

A method is proposed to optimize the definition of existing photometric filters in order to minimize passband-matching problems. It is argued that the "improved" systems should generally yield better ... [more ▼]

A method is proposed to optimize the definition of existing photometric filters in order to minimize passband-matching problems. It is argued that the "improved" systems should generally yield better astrophysical parameters than the original ones. Although of a general scope, the method is checked on intermediate-passband filters of the Stroemgren system. [less ▲]

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See detailInfrared aperture photometry at ESO (1983-1994) and its future use.
van der Bliek, N. S.; Manfroid, Jean ULg; Bouchet, P.

in Astronomy and Astrophysics. Supplement Series (1996), 119

We describe the infrared (IR) photometric system for the single channel photometers at ESO, which have been used from 1983 until 1994. In addition to the broadband near infrared (NIR, 1-5μm) photometric ... [more ▼]

We describe the infrared (IR) photometric system for the single channel photometers at ESO, which have been used from 1983 until 1994. In addition to the broadband near infrared (NIR, 1-5μm) photometric system presented in 1991 by Bouchet et al. and Bersanelli et al., we describe a narrow-band NIR photometric system and a mid infrared (MIR, 7-20μm) photometric system. We also extend the set of NIR standard stars by Bouchet et al. towards fainter objects (K=~9). The photometric data of the standard stars in these systems were extracted from the complete IR photometric data archive of ESO, covering 10 years. The zeropoints of the NIR photometry are set by assuming that HR 3314 has a V-magnitude of 3.89, and that V-K=-0.05, J-K=-0.01, H-K=-0.01, K-L'=0.00, K-M=0.00. The zeropoints of the MIR photometry are set by assuming that the colours ofβ Hyi (HR 0098) and α CenA (HR 5459) are equal to the colours of the Sun. We adopt the absolute calibration of Megessier (1995A&A...296..771M) for the NIR and we argue that this calibration can be extrapolated to 20μm, using the MIR calibrations by Rieke et al. (1985AJ.....90..900R) and Cohen et al. (1992AJ....104.1650C). The definition of the zeropoints is consistent with the absolute calibration. We obtained accurate (Ï =~0.02mag.) NIR photometry of about 240 standard stars and MIR photometry of about 40 standard stars (Ï =~0.04mag). Comparison of our NIR photometric system with other well established systems shows that there are some small colour dependencies and zeropoint offsets which are always smaller than about 0.02mag. except for the L' band. [less ▲]

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See detailLe diabète insulinodépendant
Geenen, Vincent ULg

in Revue Médicale de Liège (1996), 51(11), 684-94

Par son caractère chronique et la gravité de ses complications à long terme, le diabète insulino-dépendant (DID) constitue une véritable leçon de modestie pour le médecin à la fin de ce siècle. Le DID est ... [more ▼]

Par son caractère chronique et la gravité de ses complications à long terme, le diabète insulino-dépendant (DID) constitue une véritable leçon de modestie pour le médecin à la fin de ce siècle. Le DID est un modèle de maladie autoimmune spécifique d'organe et même d'une cellule particulière, la cellule ß insulino-sécrétrice des îlots de Langerhans dans le pancréas. Parler de maladie autoimmune signifie aussi rupture de la tolérance immunitaire vis-à-vis d'un composant du Soi. La connaissance des mécanismes responsables de la tolérance de la cellule ß et la compréhension des phénomènes génétiques et environnementaux impliqués dans sa rupture permettront la mise au point d'une prévention efficace, voire d'une éradication complète du DID. La vaccination 'tolérogène' basée sur la connaissance des antigènes thymiques responsables de l'éducation immunitaire au Soi constitute une de ces voies d'avenir prometteuse. [less ▲]

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See detail‘Bourgeoisie’, ‘massa’ en ‘volk’. Een kader voor de (re)constructie van Van Ostaijens ontwikkeling
Spinoy, Erik ULg

in Ons Erfdeel (1996), 39(5), 663-672

This article attempts to reframe the literary work of the modernist writer Paul van Ostaijen by focusing on his construction of his supposedly 'avant-gardist' position in society: anti-establishment and ... [more ▼]

This article attempts to reframe the literary work of the modernist writer Paul van Ostaijen by focusing on his construction of his supposedly 'avant-gardist' position in society: anti-establishment and anti-elitist, but also aloof of the 'ignorant' and gullible masses. [less ▲]

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See detailExpression of the 67-Kd Laminin Receptor, Galectin-1, and Galectin-3 in Advanced Human Uterine Adenocarcinoma
van den Brule, F. A.; Buicu, C.; Berchuck, A. et al

in Human Pathology (1996), 27(11), 1185-91

Alterations of tumor cell interactions with laminin, a basement membrane glycoprotein, are consistent features of the invasive and metastatic phenotype. Qualitative and quantitative changes in the ... [more ▼]

Alterations of tumor cell interactions with laminin, a basement membrane glycoprotein, are consistent features of the invasive and metastatic phenotype. Qualitative and quantitative changes in the expression of cell surface laminin-binding proteins have been correlated with the ability of cancer cells to cross basement membranes during the metastatic cascade. Such phenotypic modifications are usually associated with poor prognosis. In this study, the authors examined the possibility that expression of three laminin-binding proteins, the 67-kD laminin receptor (67LR), galectin-1, and galectin-3, is altered in human endometrial cancer in a fashion similar to that reported in other carcinomas, such as breast, colon, and ovarian cancer. Twenty advanced uterine adenocarcinomas were analyzed for expression of these three molecules using immunoperoxidase staining and specific antibodies. The authors found a significant increase in the expression of the 67LR and galectin-1 in cancer cells compared with normal adjacent endometrium (P = .0004 and .0022, respectively). As observed in other carcinomas, a significant down-regulation of galectin-3 expression was found in endometrial cancer cells compared with normal mucosa (P = .02). In the galectin-3 positive tumors, galectin-3 was detected in the cytoplasm and/or nucleus of cancer cells. Interestingly, tumors in which galectin-3 was detected only in the cytoplasm were characterized by deeper invasion of the myometrium than lesions where galectin-3 was found both in nucleus and cytoplasm (P = .02). This study shows an alteration of nonintegrin laminin-binding protein expression in advanced human endometrial cancer. Further studies on larger populations should determine the prognostic value of the detection of these laminin-binding proteins in endometrial carcinoma. Inverse modulation of the 67LR and galectin-3 appears to be a phenotypical feature of invasive carcinoma. [less ▲]

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See detailLes prions, aspects moleculaires
Rentier, Bernard ULg

in Revue Médicale de Liège (1996), 51(11), 700-705

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See detailStructural and Functional Analysis of Bovine Herpesvirus 1 Minor Glycoproteins
Baranowski, Eric; Keil, Günther; Lyaku, Japhet et al

in Veterinary Microbiology (1996), 53(1-2), 91-101

This paper focuses on the structure and functions of bovine herpesvirus 1 minor glycoproteins gH, gE, gG and gp42. It reviews the progress which has been made in their identification and characterization ... [more ▼]

This paper focuses on the structure and functions of bovine herpesvirus 1 minor glycoproteins gH, gE, gG and gp42. It reviews the progress which has been made in their identification and characterization, in the study of their temporal expression and processing in infected cells, and finally in the understanding of their biological activities. In addition, aspects discussed include a comparison with two other alphaherpesviruses, namely herpes simplex virus and pseudorabies virus. [less ▲]

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See detailLessons to be learned from varicella-zoster virus
Rentier, Bernard ULg; Piette, Jacques ULg; Baudoux, Laurence et al

in Veterinary Microbiology (1996), 53(1-2), 55-66

Varicella-zoster virus (VZV) is an alphaherpesvirus responsible for two human diseases: chicken pox and shingles. The virus has a respiratory port of entry. After two successive viremias, it reaches the ... [more ▼]

Varicella-zoster virus (VZV) is an alphaherpesvirus responsible for two human diseases: chicken pox and shingles. The virus has a respiratory port of entry. After two successive viremias, it reaches the skin where it causes typical lesions. There, it penetrates the peripheral nervous system and it remains latent in dorsal root ganglia. It is still debatable whether VZV persists in neurons or in satellite cells. During latency, VZV expresses a limited set of transcripts of its immediate early (IE) and early (E) genes but no protein has been detected. Mechanisms of reactivation from ganglia have not been identified. However, dysfunction of the cellular immune system appears to be involved in this process. The cell-associated nature of VZV has made it difficult to identify a temporal order of gene expression, but there appears to be a cascade mechanism as for HSV-1. The lack of high titre cell-free virions or recombination mutants has hindered so far the understanding of VZV gene functions. Five genes, ORFs 4, 10, 61, 62, and 63 that encode regulatory proteins could be involved in VZV latency. ORF4p activates gene promoters with basal activities. ORF10p seems to activate the ORF 62 promoter. ORF61p has trans-activating and trans-repressing activities. The major IE protein ORF62p, a virion component, has DNA-binding and regulatory functions, transactivates many VZV promoters and even regulates its own expression. ORF63p is a nuclear IE protein of yet unclear regulatory functions, abundantly expressed very early in infection. We have established an animal model of VZV latency in the rat nervous system, enabling us to study the expression of viral mRNA and protein expression during latency, and yielding results similar to those found in humans. This model is beginning to shed light on the molecular events in VZV persistent infection and on the regulatory mechanisms that maintain the virus in a latent stage in nerve cells. [less ▲]

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See detailPotentiation of the Pro-Inflammatory Effects of Bradykinin by Inhibition of Angiotensin-Converting Enzyme and Aminopeptidase P in Rat Paws
Damas, Jacques ULg; Liégeois, Jean-François ULg; Simmons, W. H.

in Naunyn-Schmiedeberg's Archives of Pharmacology (1996), 354(5), 670-6

The influence of some peptidase inhibitors on oedema and plasma extravasation induced by bradykinin and carrageenan in rat paw was evaluate. Bradykinin-induced oedema in normal rats was increased by o ... [more ▼]

The influence of some peptidase inhibitors on oedema and plasma extravasation induced by bradykinin and carrageenan in rat paw was evaluate. Bradykinin-induced oedema in normal rats was increased by o-phenanthroline (3.10(-2) M), by captopril (10(-6) M to 10(-4) M), by lisinopril (10(-6) M to 10(-4), or by lisinopril (10(-5) M) in combination with apstatin (8.10(-5) M or 1.4 10(-4) M). It was not modified by phosphoramidon (10(-6) M to 10(-5) M) and by diprotin A (10(-3) M). It was increased by mergepta at high concentrations (2.10(-4) M). Mergepta did not increase the potentiating effect of captopril. Carrageenan-oedema in normal rats was increased by captopril (10(-5) M), lisinopril (10(-5) M) and apstatin (1.4 10(-4) M. It was not modified by mergepta (10(-4) M), phosphoramidon (10 (-5) M) and diprotin A (109-3) M). Des-Arg1-bradykinin and Des-Arg9-bradykinin have low oedema-promoting effects. Captopril (10(-5) M) increased the effects of bradykinin but not those of carrageenan in kininogen-deficit Brown Norway rats. Angiotensin-converting enzyme and aminopeptidase P appear to be main kinin-inactivating enzymes in rat paws. Carboxypeptidase N, neutral endopeptidase 24.11 and dipeptidyl(amino)peptidase IV do not play a significant role in this inactivation. [less ▲]

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See detailA toy model for life at the "edge of chaos"
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Computers & Graphics (1996), 20(6), 921-923

In this short paper, we illustrate the emergence of complex structures from a simple model of life at the "edge of chaos". The visualization of the generated patterns provides a good way for understanding ... [more ▼]

In this short paper, we illustrate the emergence of complex structures from a simple model of life at the "edge of chaos". The visualization of the generated patterns provides a good way for understanding the self-organized critical dynamics of the model. [less ▲]

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See detailThe Role of Glycoproteins gC, gE, gI and gG in the Induction of Cell-Mediated Immune Responses to Bovine Herpesvirus 1
Denis, M.; Hanon, E.; Rijsewijk, F. A. et al

in Veterinary Microbiology (1996), 53(1-2), 121-32

Mutant viruses with deletions in genes encoding non-essential glycoproteins are considered as promising bovine herpesvirus 1 (BHV1) vaccine candidates. The present study compared the influence of various ... [more ▼]

Mutant viruses with deletions in genes encoding non-essential glycoproteins are considered as promising bovine herpesvirus 1 (BHV1) vaccine candidates. The present study compared the influence of various gene deletions (gC, gE, gI, gG) on the induction of cell-mediated immune responses against the virus. The highest BHV1 specific lymphoproliferative response was observed in the group of calves inoculated with the gC- mutant. However, in all groups of inoculated calves, limiting dilution analysis showed marked individual variability in the number of BHV1 specific T lymphocytes that were stimulated. The same animals were then challenged with wild-type BHV1. In these animals, limiting dilution analysis did not reveal gE, gI nor gG as a major T lymphocyte antigen. However, further analysis suggested the T cell antigenicity of gE in a low number of BHV1 hyperimmunized calves. Stimulation of MHC unrestricted cytotoxicity was also evaluated after inoculation with the various deletion mutants. Cytotoxicity in gC- inoculated calves was as high as in BHV1 inoculated calves. In conclusion, among the BHV1 deletion mutants that were tested, the gC- mutant stimulated the best cell-mediated immune responses. [less ▲]

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See detailPolyimide foams derived from a high Tg polyimide with grafted poly(α-methylstyrene)
Hedrick, James L; DiPietro, R.; Plummer, C. J. G. et al

in Polymer (1996), 37(23), 5229-5236

A new route to high-Tg, thermally stable polyimide foams has been developed. Foams were prepared by casting microphase-separated graft copolymers comprising a thermally stable main chain, polyimide, and a ... [more ▼]

A new route to high-Tg, thermally stable polyimide foams has been developed. Foams were prepared by casting microphase-separated graft copolymers comprising a thermally stable main chain, polyimide, and a thermally labile graft, poly(α-methylstyrene). The copolymer compositions were designed so that the thermally labile block would be the dispersed phase. This can unzip to its monomer upon heating, and the decomposition product diffuses out of the film, leaving pores embedded in a matrix of the thermally stable component. The copolymers were synthesized through either the poly(amic acid) precursor, followed by chemical cyclodehydration to the imide form, or the poly(amic alkyl ester) precursor followed by thermal imidization. The decomposition of the α-methylstyrene in the block copolymer was studied by thermogravimetric, dynamic mechanical and thermomechanical analyses. Mild decomposition conditions were required to avoid rapid depolymerization of the α-methylstyrene and excessive plasticization of the polyimide matrix. The foams showed pore sizes with diameters ranging from less than 20 nm to over 1 µm, depending upon the synthetic route employed, and the reduction in the mass density was generally consistent with the starting composition. [less ▲]

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