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See detailAutour d'Henri Bles à Liège
Allart, Dominique ULg; Fraiture Pascale; Oger, Cécile ULg et al

in Feuillets de la Cathédrale de Liège (2001), 46-53

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See detailDonnées récentes sur la pathogenèse de l'infection à Microsporum canis chez les carnivores domestiques
Brouta, F.; Descamps, F.; Losson, Bertrand ULg et al

in Annales de Médecine Vétérinaire (2001), 145

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See detailDernier hoquet à Francorchamps
Abu Dalu, Firass ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailIatrogenic thyrotoxicosis. Causal circumstances, pathophysiology and principles of treatment. Review of the literature
Meurisse, Michel ULg; Preud'Homme, Laurence ULg; Lamberty, Geoffrey ULg et al

in Acta Chirurgica Belgica (2001), 101(6), 257-266

Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances, thyrotoxicosis is due to hyperthyroidism, a term reserved ... [more ▼]

Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances, thyrotoxicosis is due to hyperthyroidism, a term reserved for disorders characterized by overproduction of thyroid hormones by the thyroid gland. Nevertheless, thyrotoxicosis may also result from a variety of conditions other than thyroid hyperfunction. The present report focuses on the etiologies, pathophysiology and treatment of iatrogenic thyrotoxicosis. Iatrogenic thyrotoxicosis may be caused by 1) subacute thyroiditis (a result of lymphocytic infiltration, cellular injury, trauma or radiation) with release of preformed hormones into circulation, 2) excessive ingestion of thyroid hormones ("thyrotoxicosis factitia"), 3) iodine-induced hyperthyroidism (radiological contrast agents, topical antiseptics or other medications). Among these causes of iatrogenic thyrotoxicosis, that induced by the iodine overload and cytotoxicity associated with amiodarone represents a significant challenge. Successful management of amiodarone-induced thyrotoxicosis requires close cooperation between endocrinologists and endocrine Surgeons. Surgical treatment may have a leading yet often underestimated role in view of the potential life-threatening severity of this disease, whereas others kinds of iatrogenic thyrotoxicosis are usually treated conservatively. [less ▲]

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See detailMonitoring of erythropoiesis by the serum transferrin receptor and erythropoietin.
Fillet, Georges ULg; Beguin, Yves ULg

in Acta Clinica Belgica (2001), 56(3), 146-54

Virtually all cells have transferrin receptors (a transmembrane glycoprotein) on their surface but in a normal adult, 80% of them are in the erythroid marrow. Some of them are lost into the circulation ... [more ▼]

Virtually all cells have transferrin receptors (a transmembrane glycoprotein) on their surface but in a normal adult, 80% of them are in the erythroid marrow. Some of them are lost into the circulation where they can be measured by immuno-assays. A direct and highly significant correlation exists between serum transferrin receptor level and erythron transferrin uptake in humans. The measurement of serum transferrin receptor has wide clinical applications for the quantitation of erythropoiesis. It can be used to study erythropoiesis in situations in which ferrokinetics is not acceptable such as pregnancy. It is particularly useful for serial studies, e.i., for monitoring the recovery of erythropoiesis after stem cell transplantation or after treatment with erythropoietin. Combined with the determination of serum erythropoietin, both evaluated in relation to the degree of anemia, they provide a physiological approach to the diagnosis of anemia. Thus, the simultaneous determination of hematocrit, reticulocytes, serum transferrin receptor and serum erythropoietin has high discriminatory value in distinguishing between a defect in erythroid proliferation, maturation or red cell survival. It is also particularly useful for detecting the presence of multiple mechanisms of anemia in the same patient. [less ▲]

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See detailEffect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.
Neer, R M; Arnaud, C D; Zanchetta, J R et al

in New England Journal of Medicine [=NEJM] (2001), 344(19), 1434-41

BACKGROUND: Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown ... [more ▼]

BACKGROUND: Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown. METHODS: We randomly assigned 1637 postmenopausal women with prior vertebral fractures to receive 20 or 40 microg of parathyroid hormone (1-34) or placebo, administered subcutaneously by the women daily. We obtained vertebral radiographs at base line and at the end of the study (median duration of observation, 21 months) and performed serial measurements of bone mass by dual-energy x-ray absorptiometry. RESULTS: New vertebral fractures occurred in 14 percent of the women in the placebo group and in 5 percent and 4 percent, respectively, of the women in the 20-microg and 40-microg parathyroid hormone groups; the respective relative risks of fracture in the 20-microg and 40-microg groups, as compared with the placebo group, were 0.35 and 0.31 (95 percent confidence intervals, 0.22 to 0.55 and 0.19 to 0.50). New nonvertebral fragility fractures occurred in 6 percent of the women in the placebo group and in 3 percent of those in each parathyroid hormone group (relative risk, 0.47 and 0.46, respectively [95 percent confidence intervals, 0.25 to 0.88 and 0.25 to 0.861). As compared with placebo, the 20-microg and 40-microg doses of parathyroid hormone increased bone mineral density by 9 and 13 more percentage points in the lumbar spine and by 3 and 6 more percentage points in the femoral neck; the 40-microg dose decreased bone mineral density at the shaft of the radius by 2 more percentage points. Both doses increased total-body bone mineral by 2 to 4 more percentage points than did placebo. Parathyroid hormone had only minor side effects (occasional nausea and headache). CONCLUSIONS: Treatment of postmenopausal osteoporosis with parathyroid hormone (1-34) decreases the risk of vertebral and nonvertebral fractures; increases vertebral, femoral, and total-body bone mineral density; and is well tolerated. The 40-microg dose increased bone mineral density more than the 20-microg dose but had similar effects on the risk of fracture and was more likely to have side effects. [less ▲]

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See detailLes mélèzes
Rondeux, Jacques ULg; Pauwels, D.

in Fiche technique (2001)

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See detailProperties of ordinary and exotic hadrons
Stancu, Floarea ULg

in Few-Body Systems Supplementum (2001), 13

I discuss properties of ordinary and exotic hadrons as described by two distinct constituent quark models. These are the one gluon exchange (OGE) and the Goldstone boson exchange (GBE) models. I also ... [more ▼]

I discuss properties of ordinary and exotic hadrons as described by two distinct constituent quark models. These are the one gluon exchange (OGE) and the Goldstone boson exchange (GBE) models. I also discuss the interaction between hadrons starting from their quark structure. The case of the $NN$ is presented in some details. [less ▲]

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See detailEquilibrium charge-state distributions of sodium ions in carbon foil
Tordoir, Xavier ULg; Bastin, Thierry ULg; Dumont, Paul-Dominique ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2001), 173

The equilibrium charge-state distributions have been measured for sodium ions at the exit of a carbon foil for energies ranging from 0.43 to 1.66 Me V. A comparison of our results with available models is ... [more ▼]

The equilibrium charge-state distributions have been measured for sodium ions at the exit of a carbon foil for energies ranging from 0.43 to 1.66 Me V. A comparison of our results with available models is performed and an empirical formula for calculating the charge-state fractions of sodium ions is deduced. [less ▲]

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See detailDoes ovarian surgery for endometriomas impair the ovarian response to gonadotropin?
Donnez, Jacques; Wyns, Christine; NISOLLE, Michelle ULg

in Fertility and Sterility (2001), 76(4), 662-5

Objective: To evaluate the ovarian response to stimulation conducted for IVF treatment in women who have undergone conservative surgery for endometriomas. Design: Retrospective study with prospective ... [more ▼]

Objective: To evaluate the ovarian response to stimulation conducted for IVF treatment in women who have undergone conservative surgery for endometriomas. Design: Retrospective study with prospective selection of participants and controls. Setting: University infertility clinic. Patient(s): A series of 374 women who underwent in vitro fertilization (IVF). The study group consisted of 85 patients with ovarian endometriomas who had undergone laparoscopic surgery in an attempt to become pregnant, but had failed within a year of surgery. The control group consisted of 289 patients with tubal factor infertility. Intervention(s): IVF-embryo transfer procedures. Main Outcome Measure(s): Stimulation parameters, fertilization, implantation, and pregnancy rates were analyzed in both groups. Result(s): There was no significant difference between the two groups in stimulation parameters or IVF outcome. Conclusion(s): A total of 820 cycles were analyzed. A similar IVF-ET outcome was observed in patients with endometriosis after ablation of endometriomas compared to women with tubal factors. In conclusion, endometrioma surgery by internal wall vaporization does not impair IVF outcome. The clinical pregnancy rate was respectively 37.4% and 34.6% in the endometriosis group and the control group. [less ▲]

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See detailTriassic and Jurassic lithostratigraphic units (Belgian Lorraine)
Boulvain, Frédéric ULg; Belanger, I.; Delsate, D. et al

in Geologica Belgica (2001), 4(1-2), 113-119

A multidisciplinary study of some extensively cored boreholes together with the new 1/25,000 geological mapping of Wallonia led us to propose a new lithostratigraphic canvas for Belgian Lorraine. This ... [more ▼]

A multidisciplinary study of some extensively cored boreholes together with the new 1/25,000 geological mapping of Wallonia led us to propose a new lithostratigraphic canvas for Belgian Lorraine. This area is located on the NE border of the Paris Basin, south of the Ardennes; the studied stratigraphic interval covers the Keuper to the Bajocian. [less ▲]

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See detailAuto-observation des modalites d'apprentissage en situation de projet. Metacognition mathetique au cours de PARMs; L'universite, un espace d'innovation pedagogique ?
Leclercq, Dieudonné ULg; Denis, Brigitte ULg

in Revue des Sciences de l'Education (2001), 27(2), 421-440

This article presents the training objectives (motivational, metacognitive, instrumental, and disciplinary) of a pedagogical method known as PARMs (multimedia reciprocal animation project) and procedures ... [more ▼]

This article presents the training objectives (motivational, metacognitive, instrumental, and disciplinary) of a pedagogical method known as PARMs (multimedia reciprocal animation project) and procedures for self-observation of learning as experienced by university students. The authors describe a series of didactic-mathetic activities related to training objectives, as well as those learning strategies promoted in the PARMs course. Two instruments to measure metacognitive thinking are presented: « Questionnaire on progress » and « Questionnaire on mathetical self-description ». The results of these questionnaires is then discussed. [less ▲]

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See detailQuelques outils numériques de gestion des eaux de surface
Pirotton, Michel ULg; Lejeune, André ULg; Archambeau, Pierre ULg et al

in Bulletin de l'A.I.Lg (2001), (2), 29-31

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See detailThe effect of food on growth and metamorphosis of paedomorphs in Triturus alpestris apuanus
Denoël, Mathieu ULg; Poncin, Pascal ULg

in Archiv für Hydrobiologie (2001), 152(4), 661-670

The effect of food level on growth and metamorphosis of paedomorphs was examined in an experimental replicated design in Triturus alpestris apuanus. Paedomorphosis concerns the retention of larval ... [more ▼]

The effect of food level on growth and metamorphosis of paedomorphs was examined in an experimental replicated design in Triturus alpestris apuanus. Paedomorphosis concerns the retention of larval characteristics in adult individuals. Newts that forgo metamorphosis and then retain gill and gill slits in the adult stage maintain an aquatic life but keep potential for undergoing metamorphosis. Paedomorphs metamorphosed later in treatments with food as a non-limiting factor than in stressful treatments where food was limited. Timing of metamorphosis did not differ between males and females. Food level greatly affected growth rates. These results confirm and extend optimality models that predict paedomorphosis under advantageous aquatic conditions (paedomorph advantage hypothesis) and metamorphosis in stressful aquatic habitats. [less ▲]

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See detailThiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies.
Mollard, C.; Moali, C.; Papamicael, C. et al

in Journal of Biological Chemistry (2001), 276(48), 45015-23

Resistance to beta-lactam antibiotics mediated by metallo-beta-lactamases is an increasingly worrying clinical problem. Candidate inhibitors include mercaptocarboxylic acids, and we report studies of a ... [more ▼]

Resistance to beta-lactam antibiotics mediated by metallo-beta-lactamases is an increasingly worrying clinical problem. Candidate inhibitors include mercaptocarboxylic acids, and we report studies of a simple such compound, thiomandelic acid. A series of 35 analogues were synthesized and examined as metallo-beta-lactamase inhibitors. The K(i) values (Bacillus cereus enzyme) are 0.09 microm for R-thiomandelic acid and 1.28 microm for the S-isomer. Structure-activity relationships show that the thiol is essential for activity and the carboxylate increases potency; the affinity is greatest when these groups are close together. Thioesters of thiomandelic acid are substrates for the enzyme, liberating thiomandelic acid, suggesting a starting point for the design of "pro-drugs." Importantly, thiomandelic acid is a broad spectrum inhibitor of metallo-beta-lactamases, with a submicromolar K(i) value for all nine enzymes tested, except the Aeromonas hydrophila enzyme; such a wide spectrum of activity is unprecedented. The binding of thiomandelic acid to the B. cereus enzyme was studied by NMR; the results are consistent with the idea that the inhibitor thiol binds to both zinc ions, while its carboxylate binds to Arg(91). Amide chemical shift perturbations for residues 30-40 (the beta(3)-beta(4) loop) suggest that this small inhibitor induces a movement of this loop of the kind seen for other larger inhibitors. [less ▲]

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See detailStudies in Bacidia sensu lato (lichenized Ascomycetes: Lecanorales). II. Six new combinations in Fellhanera Vezda
Lücking, Robert; Cáceres, M.E.S.; Kalb, Klaus et al

in Lichenologist (2001), 33

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See detailLa lecture littéraire : le pour et le contre
Dumortier, Jean-Louis ULg

in Education-Formation (2001), 262

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See detailA comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatment of patients with osteoarthritis of the lumbar spine.
Valat, J P; Accardo, S; REGINSTER, Jean-Yves ULg et al

in Inflammation Research (2001), 50(Suppl 1), 30-4

OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine. SUBJECTS: 229 patients with ... [more ▼]

OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine. SUBJECTS: 229 patients with radiologically confirmed osteoarthritis of the lumbar spine. TREATMENT AND METHODS: Once-daily meloxicam 7.5 mg tablet or diclofenac 100 mg slow release tablet. Efficacy and tolerability parameters were assessed at baseline and after 3, 7 and 14 days of treatment. RESULTS: The two drugs had equal short-term efficacy, with pain on motion of lumbar spine significantly (p<0.05) decreased at Day 3. Secondary efficacy variables were also significantly improved at Days 3, 7 and 14. There were no statistically significant differences between the two drugs, although the global tolerability of meloxicam was significantly better than for diclofenac, as assessed by the investigators (p = 0.0072) and the patients (p = 0.049). CONCLUSIONS: Meloxicam and diclofenac were equivalent in relieving the acute pain associated with osteoarthritis of the lumbar spine. However, meloxicam was much better tolerated. [less ▲]

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See detailInfluence of electrical properties on the evaluation of the surface hydrophobicity of Bacillus subtilis
Ahimou, F.; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Journal of Microbiological Methods (2001), 45(2), 119-126

The surface hydrophobicity of nine Bacillus subtilis strains in different states (spores, vegetative cells, and dead cells) was assessed by water contact angle measurements, hydrophobic interaction ... [more ▼]

The surface hydrophobicity of nine Bacillus subtilis strains in different states (spores, vegetative cells, and dead cells) was assessed by water contact angle measurements, hydrophobic interaction chromatography (HIC) and bacterial adhesion to hydrocarbon (BATH). Electrokinetic properties of B, subtilis strains were characterized by zeta potential measurements and found to differ appreciably according to the strain, Correlations between HIC data, BATH data and zeta potential showed that HIC and RATH are influenced by electrostatic interactions. Water contact angle measurements thus provide a better estimate of cell surface hydrophobicity. The water contact angle of B. subtilis varied according to the strain and the state, the spores tending to be more hydrophobic than vegetative cells. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailA world monograph of the lichen genus Gyalectidium (Gomphillaceae)
Ferraro, Lidia Itati; Lücking, Robert; Sérusiaux, Emmanuël ULg

in Botanical Journal of the Linnean Society (2001), 137

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See detailc-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells.
Minet, E.; Michel, G.; Mottet, Denis ULg et al

in Experimental Cell Research (2001), 265(1), 114-24

Hypoxia is an important pathophysiological stress that occurs during blood vessel injuries and tumor growth. It is now well documented that hypoxia leads to the activation of several transcription factors ... [more ▼]

Hypoxia is an important pathophysiological stress that occurs during blood vessel injuries and tumor growth. It is now well documented that hypoxia leads to the activation of several transcription factors which participate in the adaptive response of the cells to hypoxia. Among these transcription factors, AP-1 is rapidly activated by hypoxia and triggers bFGF, VEGF, and tyrosine hydroxylase gene expression. However, the mechanisms of AP-1 activation by hypoxia are not well understood. In this report, we studied the events leading to AP-1 activation in hypoxia. We found that c-jun protein accumulates in hypoxic HepG2 cells. This overexpression is concomitant with c-jun phosphorylation and JNK activation. Moreover, we showed that AP-1 is transcriptionally active. We also observed that AP-1 transcriptional activity is inhibited by a MEKK1 dominant negative mutant. Moreover, the MEKK1 dominant negative mutant as well as deletion of the AP-1 binding sites within the c-jun promoter inhibited the c-jun promoter activation by hypoxia. All together, these results indicate that, in hypoxic HepG2 cells, AP-1 is activated through a JNK-dependent pathway and that it is involved in the regulation of the c-jun promoter, inducing a positive feedback loop on AP-1 activation via c-jun overexpression. [less ▲]

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See detailAttachment of “menstrual” endometrium to peritoneum?
Donnez, Jacques; NISOLLE, Michelle ULg

in Fertility and Sterility (2001), 76(3), 642

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See detailCorrect regimen of fluoride and calcium reduces the risk of vertebral fractures in postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Rovati, L; Setnikar, I

in Osteoporosis International (2001), 12

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See detailSurface Modification of Polycarbonate and Poly(ethyleneterephthalate) Films and Membranes by Polyelectrolyte Deposition
Dauginet, Laurence; Duwez, Anne-Sophie ULg; Legras, Roger et al

in Langmuir (2001), 17

The surface modification by chemical or physical adsorption of a polyelectrolyte (polyallylamine, PAH) was established using hydrolyzed polycarbonate (PC) and poly(ethylene terephthalate) (PET) thick and ... [more ▼]

The surface modification by chemical or physical adsorption of a polyelectrolyte (polyallylamine, PAH) was established using hydrolyzed polycarbonate (PC) and poly(ethylene terephthalate) (PET) thick and thin films. Contact angle data indicated changes in the hydrophilicity of PET film surfaces in terms of the chemical treatment. XPS analysis showed that the immobilization of PAH on PET and PC films was effective and that the amount of chemically or/and physically bounded PAH depends on the pH of the electrolyte solution used for the adsorption. Similar treatments have been successfully applied to polymeric track-etched membranes. These modified membranes have been used as templates for the synthesis of polypyrrole (PPy) nanotubules. FE-SEM analysis showed that much thicker PPy tubules were obtained in modified membranes than in virgin ones. This indicates that the surface chemistry of the pore walls plays an important role in the morphology of the nanostructures synthesized within the pores [less ▲]

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See detailUne enquête internationale sur l'éducation à la citoyenneté : Connaissances, représentations, attitudes et engagement des jeunes
Lafontaine, Annette ULg; Hindryckx, Geneviève ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 59-64

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See detailThe acquired brain injuries in the term and preterm babies: an update on their pathophysiology
Battisti, Oreste ULg; Adant-François, A.; Scalais, E. et al

in Journal du Pédiatre Belge (2001), 3

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See detailImmediate and long-term clinical and angiographic results from Wiktor stent treatment for true bifurcation narrowings.
Anzuini, A.; Briguori, C.; Rosanio, S. et al

in American Journal of Cardiology (2001), 88(11), 1246-50

From January 1996 to December 1998, 90 consecutive patients with true bifurcation lesions underwent percutaneous coronary angioplasty with Wiktor stent implantation in our centers. In 1 group (group I, n ... [more ▼]

From January 1996 to December 1998, 90 consecutive patients with true bifurcation lesions underwent percutaneous coronary angioplasty with Wiktor stent implantation in our centers. In 1 group (group I, n = 45), a simple approach (main vessel stenting and balloon angioplasty of the side branch) was pursued. In the other group (group II, n = 45), both the main vessel and the side branch were stented ("T" technique). There was no significant difference in clinical and angiographic characteristics between the 2 groups. Angiographic and procedural successes were 100% and 95.6%, respectively, in both groups. Angiographic results for the side branch were better in group II than in group I. In-hospital and long-term (12 month) major cardiac events were similar in the 2 groups. Target lesion revascularization was 15.5% in group I and 35.5% in group II (p = 0.12). In the main vessel, restenosis rate was 12.5% in group I and 25% in group II (p = 0.15). In the side branch, restenosis rate was 37.5% in group II and 12.5% in group I (p = <0.05; odds ratio 2.42; 95% confidence interval 1.05 to 6.26). Event-free probability at 12 months was 61% in group II and 80% in group I (p = 0.10). When dealing with true bifurcation lesions, a simple strategy is associated with a lower risk of restenosis in the side branch. In contrast, a complex approach does not appear to give any benefit in terms of early or long-term outcome or restenosis rate. [less ▲]

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See detailA propos du remplage de la verrière d'Esther.
Morard, Thomas ULg

in Arte Cristiana (2001), 89(802), 23-30

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See detailThe Syntrichia Ruralis Complex In Belgium
Vanderpoorten, Alain ULg

in Cryptogamie Bryologie (2001), 22(2),

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See detailLa représentation des travailleurs à l’heure de la flexibilité : conséquences, enjeux et perspectives
Agro, Linda ULg; Dieu, Anne-Marie; Schoenaers, Frédéric ULg

in Revue de Gestion des Ressources Humaines (2001), 39

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See detailDégradation de dalles de tablier de ponts en Belgique. Etude d'une pathologie complexe
Demars, Philippe; Gilles, Pierre; Darimont, Anne ULg

in Bulletin des Laboratoires des Ponts et Chaussées (2001), 232

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See detailBreakpoint mapping positions the callipyge gene within a 450-kilobase chromosome segment containing the DLK1 and GTL2 genes.
Berghmans, S.; SEGERS, Karin ULg; Shay, T. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (2001), 12(2), 183-5

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See detailThe concept of age in marine modelling I. Theory and preliminary model results
Deleersnijder, Eric; Campin, Jean-Michel; Delhez, Eric ULg

in Journal of Marine Systems (2001), 28(3-4), 229-267

The age of a particle of a seawater constituent is defined to be the time elapsed since the particle under consideration left the region, in which its age is prescribed to be zero. An Eulerian theory of ... [more ▼]

The age of a particle of a seawater constituent is defined to be the time elapsed since the particle under consideration left the region, in which its age is prescribed to be zero. An Eulerian theory of the age is presented, in which advection, diffusion, production and destruction phenomena are properly accounted for. The key hypothesis is that the mean age of a set of particles is to be evaluated as the mass-weighted average of the ages of the particles under study. The basic variable is the concentration distribution function, representing, at a given time and location, the distribution over the age of the concentration of the constituent being considered. This function satisfies a partial differential equation, which, upon appropriate integration over the age, yields the equations, in flux form, governing the evolution of the concentration and the age concentration. The ratio of the latter variable to the former is the mean age. Further theoretical developments are presented, including a thought experiment showing that mixing processes cause the ages of various constituents to be different from each other. The potential of the age as a tool for understanding complex marine flows is briefly demonstrated by analysing the results of two numerical models. The ages of a passive tracer, a radioactive tracer and the water are computed, along with a suitably defined radio-age. First, the fate of tracers released into the English Channel at La Hague is simulated. Then, ages are computed in the World Ocean as a measure of the time that has elapsed since leaving the surface layers. A theorem is demonstrated, which specifies that the age of the radioactive tracer must be smaller than the relevant radio-age, the latter being smaller than the age of the passive tracer, which, under appropriate hypotheses, can be seen to be equivalent to the age of the water. These inequalities seem to be remarkably robust, since they are found to hold valid in most of the numerical and analytical results examined in the present study. On the other hand, a dimensionless number is highlighted, which is believed to play an important role in the scaling of the differences between ages. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailSize-related predation reduces intramorph competition in paedomorphic Alpine newts
Denoël, Mathieu ULg; Joly, Pierre

in Canadian Journal of Zoology (2001), 79(6), 943-948

Evolutionary theory assumes that facultative paedomorphosis in newts and salamanders is adaptive in allowing either a younger age at maturity or resource partitioning between the heterochronic morphs. In ... [more ▼]

Evolutionary theory assumes that facultative paedomorphosis in newts and salamanders is adaptive in allowing either a younger age at maturity or resource partitioning between the heterochronic morphs. In newt populations that only take the metamorphic ontogenetic pathway, juveniles are terrestrial and avoid food competition with larvae and breeding adults. In contrast, in populations where paedomorphosis occurs, branchiate newts of all sizes coexist in the aquatic habitats, posing the question of whether intramorph competition exists and its relationship with the evolution of paedomorphosis. We studied size-related predation in such a size-structured community of branchiate Alpine newts (Triturus alpestris) inhabiting a deep alpine lake. Although gape limitation may explain such size-related predation, individuals also exhibited selectivity according to prey size. Amongst small prey that were within the capture range of all newt size classes, smaller newts preyed on smaller items than did larger ones. We assume that such decisions favour the coexistence of different-sized individuals. It is suspected that such size-selective predation on items which are avoided by water-living metamorphs allows the maintenance of facultative paedomorphosis, in favouring resource partitioning between morphs. [less ▲]

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See detailComparison of deposition images obtained by use of an ultrafine 99m-technetium-labeled carbon dry aerosol with ventilation images obtained by use of 81m-krypton gas for evaluation of pulmonary dysfunction in calves.
Votion, Dominique ULg; Coghe, J. D.; Lekeux, Pierre ULg

in American Journal of Veterinary Research (2001), 62(12), 1881-6

OBJECTIVE: To characterize the accuracy of an ultrafine 99m-technetium-labeled carbon dry aerosol for use in assessment of regional ventilation in calves with pulmonary dysfunction. ANIMALS: 7 Belgian ... [more ▼]

OBJECTIVE: To characterize the accuracy of an ultrafine 99m-technetium-labeled carbon dry aerosol for use in assessment of regional ventilation in calves with pulmonary dysfunction. ANIMALS: 7 Belgian White and Blue calves. PROCEDURE: The ultrafine aerosol was assessed by comparing deposition (D) images with ventilation (V) images obtained by use of 81 m-krypton (81mKr) gas via D-to-V ratio (D:V) image analysis in calves during spontaneous breathing (SB) and during experimentally induced pulmonary dysfunction (ePD). RESULTS: Mismatching index (LrTot) calculated on the D:V images revealed a good match (LrTot, 0.96 +/- 0.01) between D and V distribution patterns in calves during SB. Calculation of the ultrafine aerosol penetration index relative to 81mKr (PIRel) revealed preferential distribution of the ultrafine aerosol in lung parenchyma (PIRel, 1.13 +/- 0.11). In ePD, heterogeneity in the D:V distribution was observed (LrTot, 0.78 +/- 0.10) as a result of ultrafine aerosol particles impaction in airways as indicated by PIRel (0.66 +/- 0.16) and a proportion of pixels more radioactive in D images, compared with V images, that was located in the central part of the lung (475 +/- 77% in ePD vs 32.8 +/- 5.7% in SB). However, this central deposition did not prevent visual examination of the entire ventilated lung. CONCLUSIONS AND CLINICAL RELEVANCE: The ultrafine aerosol appears suitable for use in examination of ventilated parts of lungs of cattle, even those with impaired pulmonary function. However, airway impaction of ultrafine aerosol particles impedes the quantification of regional ventilation in cattle with abnormal lung function. [less ▲]

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See detailA comparison of blade tip timing data analysis methods
Carrington, Ian B; Wright, Jan Robert; Cooper, Jonathan E et al

in Proceedings of the Institution of Mechanical Engineers - Part G - Journal of Aerospace Engineering (2001), 215(6), 301-312

The experimental determination of the vibration characteristics of rotating engine blades is very important for fatigue failure considerations. One of the most promising techniques for measuring the ... [more ▼]

The experimental determination of the vibration characteristics of rotating engine blades is very important for fatigue failure considerations. One of the most promising techniques for measuring the frequency of blade vibrations is blade tip timing. In this paper, three vibration analysis methods were specifically formulated and applied to the tip timing problem for the first time, using data obtained from a simple mathematical blade tip timing simulation. The results from the methods were compared statistically in order to determine which of the techniques is more suitable. One of the methods, the global autoregressive instrumental variables approach, produced satisfactory results at realistic noise levels. However, all of the techniques produced biased results under certain circumstances. [less ▲]

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See detailA Parametric Distance Function Approach for Malmquist Productivity Index Estimation
Fuentes, Hugo J.; Grifell-Tatjé, Emili; Perelman, Sergio ULg

in Journal of Productivity Analysis (2001), 15

Malmquist indexes of productivity are generally estimated using index number techniques or non-parametric frontier approaches. The aim of this paper is to showthat Malmquist indexes can be estimated in a ... [more ▼]

Malmquist indexes of productivity are generally estimated using index number techniques or non-parametric frontier approaches. The aim of this paper is to showthat Malmquist indexes can be estimated in a similar way using parametric-deterministic or parametric-stochastic frontier approaches. To allow a multi-output multi-input technology and for technical change in production, we adopt an output distance function which is specified in a translog form. We then show that using the estimated parameters, several radial distance functions can be calculated and combined in order to estimate and decompose the productivity index. Finally, this approach is applied to a panel of Spanish insurance companies. The main results confirm those generally obtained for financial services: very low rates of growth and technical change in spite of a rapid deregulation process and expansion of activity. [less ▲]

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See detailRole Of The Proline-Rich Motif Of Bovine Leukemia Virus Transmembrane Protein Gp30 In Viral Load And Pathogenicity In Sheep
Reichert, M.; Winnicka, A.; Willems, Luc ULg et al

in Journal of Virology (2001), 75(17),

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See detailEvidence of rainbow trout prolactin interaction with its receptor through unstable homodimerisation.
Le Rouzic, Philippe; Sandra, Olivier; Grosclaude, Jeanne et al

in Molecular & Cellular Endocrinology (2001), 172(1-2), 105-13

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow ... [more ▼]

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow trout intestine cDNA library with a probe corresponding to the extracellular domain (ECD) of tilapia PRLR, we have cloned a 2.5 kb insert coding for the PRLR. The mature protein of 614 amino acid residues is similar to PRLR isolated in tilapia and also the long form of mammalian PRLR. Analysis of PRLR gene expression in osmoregulatory organs revealed the presence of a unique transcript, thus confirming the involvement of this hormone in the control of osmoregulation in this fish species. By using surface plasmon resonance (SPR) technology, kinetic measurement of interaction between trout PRL and its receptor ECD was studied. This approach allowed us to demonstrate the formation of a transient, unstable homodimeric complex. This unstability could explain the inability to perform binding experiments using homologous PRL. In contrast, heterologous lactogenic ligands were able to interact through a more stable complex. Whether these characteristics of PRL-receptor interaction in rainbow trout are different to what occurs in tilapia where a homologous radioreceptor assay was developed would require further studies. [less ▲]

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See detailLe débiteur et le contenu d'une garantie sujets à discussion
Paris, Catherine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailStrontium ranelate increases cartilage matrix formation.
Henrotin, Yves ULg; Labasse, Alain; Zheng, S. X. et al

in Journal of Bone and Mineral Research (2001), 16(2), 299-308

Based on previous studies showing that strontium ranelate (S12911) modulates bone loss in osteoporosis, it could be hypothesized that this drug also is effective on cartilage degradation in osteoarthritis ... [more ▼]

Based on previous studies showing that strontium ranelate (S12911) modulates bone loss in osteoporosis, it could be hypothesized that this drug also is effective on cartilage degradation in osteoarthritis (OA). This was investigated in vitro on normal and OA human chondrocytes treated or not treated with interleukin-1beta (IL-1beta). This model mimics, in vitro, the imbalance between chondroformation and chondroresorption processes observed in vivo in OA cartilage. Chondrocytes were isolated from cartilage by enzymatic digestion and cultured for 24-72 h with 10(-4)-10(-3) M strontium ranelate, 10(-3) M calcium ranelate, or 2 x 10(-3) M SrCl2 with or without IL-1beta or insulin-like growth factor I (IGF-I). Stromelysin activity and stromelysin quantitation were assayed by spectrofluorometry and enzyme amplified sensitivity immunoassay (EASIA), respectively. Proteoglycans (PG) were quantified using a radioimmunoassay. Newly synthesized glycosaminoglycans (GAGs) were quantified by labeled sulfate (Na2(35)SO4) incorporation. This method allowed the PG size after exclusion chromatography to be determined. Strontium ranelate, calcium ranelate, and SrCl2 did not modify stromelysin synthesis even in the presence of IL-1beta. Calcium ranelate induced stromelysin activation whereas strontium compounds were ineffective. Strontium ranelate and SrCl2 both strongly stimulated PG production suggesting an ionic effect of strontium independent of the organic moiety. Moreover, 10(-3) M strontium ranelate increased the stimulatory effect of IGF-I (10(-9) M) on PG synthesis but did not reverse the inhibitory effect of IL-1beta. Strontium ranelate strongly stimulates human cartilage matrix formation in vitro by a direct ionic effect without stimulating the chondroresorption processes. This finding provides a preclinical basis for in vivo testing of strontium ranelate in OA. [less ▲]

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See detailCharge critique et longueur de flambement des éléments à inertie variable et aux conditions d'extrémité élastiques
Latteur, Pierre ULg

in revue scientifique des Instituts supérieurs industriels francophones de Belgique (2001), 15

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See detailAnatomical characteristics of tension wood and opposite wood in young inclined stems of poplar (Populus euramericana cv ‘Ghoy’)
Jourez, Benoît ULg; Riboux, Alain; Leclercq, André

in IAWA Journal (2001), 22(2), 133-157

Young shoots from poplar cuttings (P. euramericana cv ‘Ghoy’) were artificially inclined to 30° from vertical to quantify the anatomical modifications induced by this gravitational stimulus. At the end of ... [more ▼]

Young shoots from poplar cuttings (P. euramericana cv ‘Ghoy’) were artificially inclined to 30° from vertical to quantify the anatomical modifications induced by this gravitational stimulus. At the end of the growing season, the tension wood tissue (from the upper face of the inclined axis) was compared to the opposite wood tissue (from the lower face), with radial position taken into account. On isolated elements after maceration, fibres and vessels were significantly longer in tension wood tissue. In the cross section, the gelatinous fibres had a smaller radial diameter than normal fibres in opposite wood. Vessel frequency and porosity were significantly lower in tension wood than opposite wood. Solitary vessels in tension wood were less circular in cross section than in opposite wood, but their surface area did not differ. Rays were more numerous in tension wood than opposite wood but their height did not differ between the two tissue types. Finally, there was a negative correlation between the proportion of vessels lumina (lowest in tension wood) and the proportion of fibres lumina including the G layer. The very controlled nature of this experiment (greenhouse, young clonal material, detailed anatomical observations within one growth ring) and the image analysis technology (allowing a large number of observations) enabled us to draw conclusions that may not have been seen in less-controlled experiments and/or those with smaller sample sizes. [less ▲]

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See detailAn overlay tree building control protocol
Mathy, Laurent ULg; Canonico, R.; Hutchison, D.

in Networked Group Communication (2001)

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See detailIonic or non-ionic contrast media during coronary intervention: does it make a difference?
Legrand, Victor ULg

in European heart journal (2001), 22(5), 353-4

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See detailEugène Monseur (1860-1912)
Boutier, Marie-Guy ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2001), (1),

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See detailPurification and characterization of a 43.5 kDa keratinolytic metalloprotease from Microsporum canis.
Brouta, F.; Descamps, F.; Fett, Thomas ULg et al

in Medical Mycology (2001), 39(3), 269-275

A keratinolytic protease secreted by a feline clinical isolate of Microsporum canis cultivated in a broth containing feline keratin as the sole nitrogen source was purified from the culture filtrate by ... [more ▼]

A keratinolytic protease secreted by a feline clinical isolate of Microsporum canis cultivated in a broth containing feline keratin as the sole nitrogen source was purified from the culture filtrate by affinity chromatography on bacitracin-agarose and by hydrophobic chromatography on octyl-agarose. The enzyme had an apparent molecular mass of 43.5 kDa and the pI was 7.7. It had a significant activity against keratin azure, elastin-Congo red and denatured type I collagen (azocoll). Using the latter substrate, the optimum pH was around 8 and the apparent optimum temperature around 50 degrees C. The protease was strongly inhibited by 1,10-phenanthroline, phosphoramidon and EDTA. The first 13 N-terminal amino acid sequence showed a 61% homology with that of the extracellular metalloprotease of Aspergillus fumigatus and with the neutral protease I of A. oryzae, confirming that this 43.5 kDa keratinase is a metalloprotease. This keratinolytic metalloprotease could be a virulence-related factor involved in pathophysiological mechanisms of M. canis dermatophytosis. [less ▲]

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See detailBinding and multiple instantiation in a distributed network of spiking nodes
Sougné, Jacques ULg

in Connection Science (2001), 13(2), 99-126

An implementation of a distributed connectionist network of spiking neuron-like elements is presented. Spiking nodes fire at a precise moment and transmit their activation, with particular strenghts and ... [more ▼]

An implementation of a distributed connectionist network of spiking neuron-like elements is presented. Spiking nodes fire at a precise moment and transmit their activation, with particular strenghts and delays, to nodes connected to them. Wen the potential of the node reaches a particular threshold, it emits a spike. Thereafter, the potential is reset to a resting value. The receiving nodes accumulate potential, but also, slowly lose their potential through decay. As with real neurons, after firing there is a short refractory period during which the node will be completely insensitive to incoming signals, after which its sensitivity will slowly increase. Precise timing properties are used to represent symbols in a distributed manner and also to solve the problems of variable binding and multiple instantiation. Several predictions about human short-term memory, predicate processing, complex reasoning and multiple instantiation arise from this model. This network shows how symbolic processing can be achieved using neurobiologically and psychologically plausible mechanisms that also have the advantages of generalization and noise tolerance found in connectionist networks. [less ▲]

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See detailPotential of the Migraine Disability Assessment (MIDAS) Questionnaire as a public health initiative and in clinical practice.
Edmeads, J.; Lainez, J. M.; Brandes, J. L. et al

in Neurology (2001), 56(6 Suppl 1), 29-34

Migraine is not always well managed in clinical practice, often being under-diagnosed and under-treated. As a result, many sufferers never consult a physician or lapse from care after physician contact ... [more ▼]

Migraine is not always well managed in clinical practice, often being under-diagnosed and under-treated. As a result, many sufferers never consult a physician or lapse from care after physician contact. Although most migraine care is provided by general practitioners, others, including specialists, emergency room physicians, pharmacists, and alternative practitioners, may also be involved. A method of standardizing clinical information about migraine is essential for coordinated, logical, and systematic care. The impact of migraine on the patient is an important clinical parameter but one that is seldom inquired about, perhaps because it exhibits such marked variability among and within individuals. Headache-related disability can be an objective and measurable index of this impact. The Migraine Disability Assessment (MIDAS) Questionnaire is a simple and validated instrument with potential for use in clinical practice, research, and public health. It can improve communication between patients and health-care professionals regarding the impact of migraine which, in turn, allows tailoring of the intensity of treatment to the severity of the illness. Changes in the MIDAS score may serve as an end point in assessing treatment efficacy. In populations, MIDAS scores may indicate the burden of migraine in the community and spark public health initiatives to improve management. [less ▲]

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See detailMercury porosimetry: applicability of the buckling-intrusion mechanism to low-density xerogels
Alié, Christelle ULg; Pirard, René ULg; Pirard, Jean-Paul ULg

in Journal of Non-Crystalline Solids (2001), 292(1-3), 138-149

Mineral materials can be either crushed or invaded by mercury during mercury porosimetry experiments. It has been shown here that many low-density xerogels exhibit the two volume variation mechanisms ... [more ▼]

Mineral materials can be either crushed or invaded by mercury during mercury porosimetry experiments. It has been shown here that many low-density xerogels exhibit the two volume variation mechanisms successively, compaction followed by intrusion. when submitted to mercury porosimetry and that a unimodal pore size distribution can be obtained by applying Pirard's collapse model below the pressure of transition P-1 and Washburn's intrusion theory above P-t. To confirm the validity of the use of the buckling law, one low-density xerogel was wrapped in a tight membrane (intrusion is prevented and the sample is crushed during the whole porosimetry experiment). The analysis of the mercury porosimetry data of the wrapped sample by the buckling law leads to a continuous unimodal distribution similar to the distribution of the unwrapped sample obtained by applying the buckling law below P-t and the intrusion law above P-t. The position of P-t is characteristic of the tested material: when submitted to mercury pressure. aerogels and low-density xerogels only collapse in case of very small aggregates whereas they are crushed and then intruded in case of larger silica aggregates. The fact that compacted slabs of monodisperse non-aggregated silica spheres (of the same size range as the xerogels and aerogels) show only intrusion during mercury porosimetry experiments implies that the particles need to be aggregated so that the compaction mechanism takes place. The position of the change of mechanism from crushing to intrusion is not directly related to the size of the elementary particles but is linked to the size of the aggregates of silica particles. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailConsidérations sur le taux du ressort lorsque les bases de détermination de la valeur du litige font défaut
Boularbah, Hakim ULg

in Revue de Droit Judiciaire et de la Preuve = Tijdschrift voor Procesrecht en Bewijsrecht (2001)

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See detailThe Secret History of Belgian Surrealism
Delville, Michel ULg

in Samizdat (2001)

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See detailMonitoring biologique des greffes de cellules souches hématopoïétiques
GOTHOT, André ULg

in Focus Diagnostica (2001), 9

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See detailLe déroulement de la conférence sur le développement rural durable dans l'ensemble des pays d'Europe.
Christians, Charles ULg; Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (2001), 41

Présentation de l'organisation, du thème, de l'objectif et des activités (travaux sur le terrain et Conférence).

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See detailLa libre circulation des personnes dans l'Union européenne (1er janvier - 31 décembre 2000)
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2001), 9(3), 65-73

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See detailLe contrôle de la constitutionnalité des lois aux Pays-Bas
Kohl, Benoît ULg

in Chroniques de Droit Public = Publiekrechtelijke Kronieken (2001)

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See detailInfluence du régime d’administration continu ou discontinu d’acétate de nomégestrol sur l’apoptose des cellules mammaires
Van den Brule, F; DESREUX, Joëlle ULg; BELIARD, Aude ULg et al

in Reproduction Humaine et Hormones (2001), 15

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See detailRole of interface deformations in Benard-Marangoni instability
Lebon, Georgy ULg; Dauby, Pierre ULg; Regnier, Vincent

in Acta Astronautica (2001), 48(5-12), 617-627

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See detailImplication de la neurohypophyse dans le stress psychique
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Legros, Jean-Jacques ULg

in Encéphale (L') (2001), 27(3, May-Jun), 245-59

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various ... [more ▼]

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various psychiatric diseases such an anorexia nervosa, bipolar disorder, schizophrenia and obsessive-compulsive disorder. AVP and OT are secreted into the hypophyseal portal circulation by neurons which project from the paraventricular nucleus to the external zone of the median eminence. AVP and OT-containing neurons in the suprachiasmatic and paraventricular nuclei project to limbic areas, including the hippocampus, the subiculum, the ventral nucleus of the amygdala and the nucleus of the diagonal band. Specific AVP receptors which are pharmacologically different from the pressor and antidiuretic AVP receptors have been found in the anterior pituitary. OT receptors have been identified in a variety of forebrain sites. The neurohypophyseal secretion is regulated by the cholinergic muscarinic, histaminergic and beta-adrenergic systems. Stress alters the secretion of one or more of the hypothalamic factors which interact at the pituitary to increase the secretion of ACTH. AVP and OT have been shown to modulate the effect of Corticotropin-Releasing Factor (CRF) on ACTH secretion and appear to play a key role in mediating the ACTH response to stress. Although AVP is a relatively weak secretagogue for ACTH, it markedly potentiates the activity of CRF both in vitro and in vivo. The role of OT is more complex. In vitro, OT stimulates ACTH release at high doses whereas in human it inhibits ACTH secretion at low doses. The type of stressor appear to determine the relative importance of these secretatogues in ACTH response. Several recent studies indicate that psychological stressors display a similar degree of variety of secretagogue release patterns as was found earlier for physical stressors. A bewildering array of technique produces a bewildering array of conclusions. In rats, OT may be an important secretagogue during a novel stimulus, whereas the role for AVP is less clear. Indeed two studies out of ten suggest a stimulating role for AVP. In response to frustration and submission, OT and AVP are secreted. Regarding social isolation, results are difficult to interpret and the role of AVP could be species-dependent. In contrast plasma OT levels do not change. After restraint, ACTH release is primarily mediated by the active increase of OT and AVP does not appear to play a role. When restraint is associated with moderate levels of physical components and during immobilisation, all two secretagogs are involved in the ACTH response. With fear, ACTH response appears to be driven by OT. In humans, one study indicates that high emotionality women increase plasma OT in response to uncontrollable noise. Various neuroendocrine dysregulations have been observed in psychiatric disease. Either an increase or a decrease of the hypothalamic-pituitary-adrenal (HPA) function have been described in several illnesses. Effects of OT appear to be reciprocal to the effects of AVP. OT has been called the "amnestic" neuropeptide due to its capacity to attenuate memory consolidation and retrieval. AVP exhibits a central activating action on mood, memory and selective attention. Underweight patients with anorexia nervosa have abnormally high levels of centrally directed AVP and reduced OT levels. These modifications could enhance the retention of cognitive distortions of aversive consequences of eating. Patients with bipolar disorder show a biphasic secretion of AVP. Depressive episodes are associated with decreased vasopressinergic activity whereas manic episodes involve an increased release. AVP might be responsible for an increased catecholamine activity. In addition, lithium could act as an antagonist to AVP. In schizophrenic patients, studies using the apomorphine stimulation suggest increased oxytoninergic and decreased vasopressinergic functions. These findings are consistent with the beneficial role of AVP on schizophrenic symptoms noted in several trials. The increased OT could be responsible for "positive" symptomatology such as delusions and hallucinations. Obsessive compulsive disorder (OCD) includes a range of cognitive and behavioral disturbances that could be influenced by OT. In animals, several studies have emphasized the role of AVP in promoting repetitive grooming behaviors and maintaining conditioned response to aversive stimuli. In OCD patients, one study have reported that AVP/OT ratio was negatively correlated with symptom severity. However, an independent report found similar AVP concentrations in OC patients without a personal or family history of tic disorder and in normal subjects. Whether these modifications are only a consequence of the central disturbances or whether those peptides could participate in the pathogenesis of these affections remains to be elucidated. [less ▲]

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See detailIntraconzole versus amphotericin B plus nystatin in the prophylaxis of fungal infections in neutropenic cancer patients
Boogaerts, Marc; Maertens, Johan; van Hoof, Achiel et al

in Journal of Antimicrobial Chemotherapy (2001), 48

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See detailAperçu du régime alimentaire du Grand Cormoran (Phalacrocorax carbo) dans les eaux intérieures du Pas-de-Calais (France)
Libois, Roland ULg

in Aves (2001), 38(2), 49-59

The stomach contents of 40 great cormorants shot during "regulation" operations in the Pas-de-Calais have been analysed. Eight stomachs were empty and 426 fishes belonging to 15 species were recovered in ... [more ▼]

The stomach contents of 40 great cormorants shot during "regulation" operations in the Pas-de-Calais have been analysed. Eight stomachs were empty and 426 fishes belonging to 15 species were recovered in the others. The dominant prey is the roach. Other regular prey are the common bream and the perch. Other fish (Salmonids, pike, pikeperch, ruffe, rudd, lamprey) appear in less than 5 stomachs. Most of the prey are small sized fish, less than 12 cm (total length). The biomass of 80% of the preys is less than 20g. However, the role of the greater fish in the diet must be emphasized: those weighing more than 200g (1% in numbers) reprensent 20% of the ingested biomass. [less ▲]

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See detailTrophic diversiy within the eastern Weddell Sea amphipod community
Dauby, Patrick ULg; Scailteur, Yves; De Broyer, Claude

in Hydrobiologia (2001), 443

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See detailMigraine
Sandor, Peter S.; Agosti, Reto; Schoenen, Jean ULg

in Pain Clinical Updates (2001), 9

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See detailStability of perturbed functional differential equations and stabilization of nonlinear cascades
Michiels, Wim; Sepulchre, Rodolphe ULg; Roose, Dirk

in SIAM Journal on Control & Optimization (2001), 40

In this paper the effect of bounded input perturbation on the stability of nonlinear globally asymptotically stable delay differential equations is analyzed. We investigate under which conditions global ... [more ▼]

In this paper the effect of bounded input perturbation on the stability of nonlinear globally asymptotically stable delay differential equations is analyzed. We investigate under which conditions global stability in preserved and if not, whether semi-global stabilization is possible by controlling the size or shape of the perturbation. This results in a general framework, in which the stabilization of partial linear cascade systems using partial state feedback can be treated systematically. [less ▲]

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See detailSecondary fabrics revealed by remanence anisotropy: methodological study and examples from plutonic rocks
Trindade, Ricardo I.F.; Bouchez, Jean-Luc; Bolle, Olivier ULg et al

in Geophysical Journal International (2001), 147(2), 310-318

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See detailQuelques spécimens exceptionnels de premières plantes terrestres découvertes au Brésil (Bassin du Paraná, Dévonien basal)
Gerrienne, Philippe ULg; Milagres, I.; Bergamaschi, S. et al

in Geo-Eco-Trop (2001), 25

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See detailExtended analysis of the spectrum of triply-ionozed Ytterbium (Yb IV) and transition probabilities
Wyart, J.-F.; Tchang-Brillet, W. U. L.; Spector, N. et al

in Physica Scripta (2001), 63

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See detailLe dispositif d'évaluation externe en Communauté française de Belgique
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 195-218

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See detailVies et Miracles de Domitien Deuxième partie
George, Philippe ULg

in Analecta Bollandiana : Revue Critique d’Hagiographie = A Journal of Critical Hagiography (2001), CXIX

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See detailHelping children to learn languages (Aider son enfant à apprendre les langues)
Blondin, Christiane ULg

in European Parents Association - Info Bulletin (2001), (Hiver 2001), 11-16

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See detailLes surcoûts de l’étalement urbain en Wallonie
Halleux, Jean-Marie ULg

in Etudes Foncières (2001), (94), 18-21

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See detailEvaluation of aphidophagous ladybird populations in a vegetable crop and implications as biological agents
Francis, Frédéric ULg; Colignon, Pierre; Haubruge, Eric ULg et al

in Med. Fac. Landbouw. Univ. Gent (2001), 66(2a), 333-340

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See detailQuantitative short-term study of Anal sphincter function after chemoradiation for rectal cancer
Gervaz, Pascal; Rotholtz, Nicolas; Pisano, Michele et al

in Langenbeck's Archives of Surgery (2001), 136

Hypothesis: Pelvic irradiation adversely affects anal sphincter function after proctectomy with coloanal anastomosis for low rectal and middle rectal (,10 cm from the anal verge) tumors. Design: Case ... [more ▼]

Hypothesis: Pelvic irradiation adversely affects anal sphincter function after proctectomy with coloanal anastomosis for low rectal and middle rectal (,10 cm from the anal verge) tumors. Design: Case-control study. Setting: Private, tertiary care referral center. Patients: Patients treated for low rectal adenocarcinoma between January 1, 1994, and October 31, 1999. Interventions: Anal manometric data were prospectively collected at the time of initial diagnosis and before ileostomy closure. Main Outcome Measures: Mean and maximum resting pressures (RPs) and squeeze pressures, threshold volume for sensation, and maximal tolerable volume. Results: Twenty-three patients in the surgery group and 19 in the chemoradiotherapy group were considered for [less ▲]

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See detailCore-polarization effects and radiative lifetime measurements in Pr III
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Palmeri, P. et al

in Physical Review. A (2001), 64

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See detailThe behavioral effects of acute and chronic JL 13, a putative antipsychotic, in Cebus non-human primates
Casey, Daniel; Bruhwyler, Jacques; Delarge, Jacques et al

in Psychopharmacology (2001), 157

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See detailComparison between the GIRBAS Scale and the Acoustic and Aerodynamic Measures Provided by EVA for the Assessment of Dysphonia following Unilateral Vocal Fold Paralysis.
Morsomme, Dominique ULg; Jamart, Jacques; Wery, Carine et al

in Folia Phoniatrica et Logopaedica (2001), 53(6), 317-25

The aim of this study is to establish relevant objective parameters for evaluating dysphonia following unilateral vocal fold paralysis. To do so, the study compares objective and perceptual voice measures ... [more ▼]

The aim of this study is to establish relevant objective parameters for evaluating dysphonia following unilateral vocal fold paralysis. To do so, the study compares objective and perceptual voice measures. The objective measures were obtained using a voice analysis software (Evaluation Vocale Assistee), whereas the perceptual measures were established with the GIRBAS Scale (grade, instability, roughness, breathiness, asthenia, and strain). All measurements were performed on 40 voice samples: 28 dysphonic subjects with unilateral laryngeal paralysis, and 12 control subjects. The intra- and inter-judge agreements were fairly good, at least for control subjects. The six GIRBAS measures obtained from the pathological voices were higher than those from the control voices (p < 0.001) and the correlation between both groups was good. Grade, breathiness and asthenia correlated with the objective parameters that express the aperiodicity of the phonatory signal (p < 0.01), namely, the coefficient of variability of the fundamental frequency, the coefficient of variability of intensity, and jitter. Our findings suggest that the perceptual reality of laryngeal paralysis-induced dysphonia depends more on grade, breathiness and asthenia than it does on roughness or instability. [less ▲]

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See detailCrystallographic analysis of family 11 endo-beta-1,4-xylanase Xyl1 from Streptomyces sp. S38.
Wouters, J.; Georis, J.; Engher, D. et al

in Acta Crystallographica Section D-Biological Crystallography (2001), 57(Pt 12), 1813-9

Family 11 endo-beta-1,4-xylanases degrade xylan, the main constituent of plant hemicelluloses, and have many potential uses in biotechnology. The structure of Xyl1, a family 11 endo-xylanase from ... [more ▼]

Family 11 endo-beta-1,4-xylanases degrade xylan, the main constituent of plant hemicelluloses, and have many potential uses in biotechnology. The structure of Xyl1, a family 11 endo-xylanase from Streptomyces sp. S38, has been solved. The protein crystallized from ammonium sulfate in the trigonal space group P321, with unit-cell parameters a = b = 71.49, c = 130.30 A, gamma = 120.0 degrees. The structure was solved at 2.0 A by X-ray crystallography using the molecular-replacement method and refined to a final R factor of 18.5% (R(free) = 26.9%). Xyl1 has the overall fold characteristic of family 11 xylanases, with two highly twisted beta-sheets defining a long cleft containing the two catalytic residues Glu87 and Glu177. [less ▲]

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See detailUretere retrocave chez un enfant de dix ans.
Kakanou, A.; NCHIMI LONGANG, Alain ULg; Ghuysen, M. S. et al

in Annales de Chirurgie (2001), 126(2), 156-8

Retrocaval ureter is an uncommon abnormality of the inferior vena cava, which is rarely detected in the child due to its non-specific symptomatology. Despite a varying state of severity, chronic ureteral ... [more ▼]

Retrocaval ureter is an uncommon abnormality of the inferior vena cava, which is rarely detected in the child due to its non-specific symptomatology. Despite a varying state of severity, chronic ureteral obstruction generally leads to the deterioration of renal function during adulthood. Treatment depends on the symptomatology in question, and surgical management should be as conservative as possible. [less ▲]

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See detailRegime alimentaire du Grand-Duc du désert, Bubo ascalaphus, dans la réserve naturelle de Mergueb (M'Sila, Algérie)
Biche, Mohamed; Sellami, Medhi; Libois, Roland ULg et al

in Alauda (2001), 69(4), 554-557

The diet of Bubo ascalaphus was studied in a steppe at the Mergueb nature reserve. The analysis of 141 pellets indicated that mammals were most abundant (89 %). The most frequent prey, on a numerical ... [more ▼]

The diet of Bubo ascalaphus was studied in a steppe at the Mergueb nature reserve. The analysis of 141 pellets indicated that mammals were most abundant (89 %). The most frequent prey, on a numerical basis (82 %) as well as in term of biomass (96 %) was Meriones shawi trouessarti (Gerbillidae). Other preys included Jaculus orientalis (Dipodidae), and two insectivores: Crocidura russula and Hemiechinus aethiopicus. Among the avifauna, only the Spanish sparrow (Passer hispaniolensis) was a significant part of the Eagle owl dietn especially in spring. Arthropods were represented by Scarabeidae in spring and Scorpionidae in summer but they played a minor role in the food of the Eagle owl. The originality of this diet lies in the absence of Brown hare (Lepus capensis) and the presence of only one specimen of the desert hedgehog. Although its food spectrum was very narrow in this site, the Eagle owl can be regarded as opportunistic as it concentrated on the most available prey: Meriones shawi. [less ▲]

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See detailUn nouveau projet archéologique de l'Université de Lyon 2.
Morard, Thomas ULg; Wavelet, David

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2001), 113(1), 477-481

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See detailGenetic markers of osteoarticular disorders: facts and hopes.
Brandi, M L; Gennari, L; Cerinic, M M et al

in Arthritis Research (2001), 3(5), 270-80

Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from ... [more ▼]

Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches. [less ▲]

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See detailIsokinetic evaluation of hip strength muscle groups in unilateral lower limb amputees
Croisier, Jean-Louis ULg; Maertens De Noordhout, Benoît ULg; Maquet, Didier ULg et al

in Isokinetics & Exercise Science (2001), 9(4), 163-169

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order ... [more ▼]

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order to improve the usual rehabilitation programs. Thirty-three patients with unilateral lower limb amputation were included in this study; they served as their own controls, the amputated side being compared to the intact side. Using an isokinetic device, the relative peak torques (N.m by body weight), bilateral asymmetries and agonist/antagonist torque ratios were calculated for the hip flexor, extensor, adductor and abductor muscle groups. A significant reduction of mean concentric relative peak torque measured on the amputated limbs was generally observed when compared to the intact contralateral limb (p < 0.05). The mean percentage of relative peak torque decrease was greater for the extensors than for the flexors (33 +/- 20% and 22 +/- 23%, respectively, at 30degrees/s angular velocity), and for the abductors than for the adductors (23 +/- 22% and 11 +/- 19%, respectively, at 30degrees/s angular velocity). Furthermore, the flexor/extensor torque ratio was significantly increased for the amputated limb (for instance, 1.25 +/- 0.33 versus 1.09 +/- 0.25 for the intact limb at 30degrees/s). The reduction of the abductor/adductor ratio of the operated limb reached the level of statistical significance at 60degrees/s only (1.25 +/- 0.46 versus 1.07 +/- 0.36 for the intact limb). In conclusion, isokinetic testing revealed a significant reduction of the hip stabilizing muscle strength as a consequence of lower limb amputation. The more marked decrease of the strength of the abductor and extensor muscle groups, resulting in imbalances of the agonist/antagonist strength ratios should be taken into account to adapt the conventional rehabilitation programs. [less ▲]

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See detailImpaired emotional facial expression in alcoholism compared with obsessive compulsive disorder and normal controls
Kornreich, C; Blairy, Sylvie ULg; Philippot, P et al

in Psychiatry Research (2001), 102

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See detailThe early Paleozoic carbon cycle
Godderis, Y.; François, Louis ULg; Veizer, J.

in Earth And Planetary Science Letters (2001), 190(3-4), 181-196

A review of O, C, Sr and S isotope trends for the entire Phanerozoic shows that the present-day values of isotope signals are similar to those at the Proterozoic termination. The sharp rise in Sr-87/Sr-86 ... [more ▼]

A review of O, C, Sr and S isotope trends for the entire Phanerozoic shows that the present-day values of isotope signals are similar to those at the Proterozoic termination. The sharp rise in Sr-87/Sr-86 since similar to 65 Ma has been attributed to an uplift and subsequent metamorphism and erosion associated with the Himalayas and Tibet. This orogenic evolution has been postulated to have influenced the global organic and inorganic carbon cycles and climate as well. A similar large-scale orogeny, the Pan-African event, also dominated the Neoproterozoic (Vendian) times, and the similarity of modern and Neoproterozoic isotope values for seawater may therefore have had a comparable tectonic cause. In this contribution, we present the results of a numerical model of the coupled C-alkalinity-S-Sr cycles suggesting that the early Paleozoic (from early Cambrian to late Devonian) evolution of Sr, O, C and S seawater isotope signals could have been the consequence of progressive oxidation of a large reduced carbon reservoir exhumed during the Pan-African orogeny. The delta O-18 measured in brachiopod shells is used as a forcing of the model, postulating that any change in the oxygen isotopic composition of seawater is the result of a disequilibrium in the organic carbon subcycle through the coupling of the oxygen isotopic and carbon cycles. The calculated delta C-13, Sr-87/Sr-86 and delta S-34 are in good agreement with the data, as is the reasonable calculated history for atmospheric pCO(2) and its relation to global climate. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailSexual compatibility between two heterochronic morphs in the Alpine newt, Triturus alpestris
Denoël, Mathieu ULg; Poncin, Pascal ULg; Ruwet, Jean-Claude

in Animal Behaviour (2001), 62(3), 559-566

Paedomorphosis, in which individuals retain ancestral characteristics in the adult stage, is widespread in newts and salamanders and is suspected to play an important role in evolution. In some species ... [more ▼]

Paedomorphosis, in which individuals retain ancestral characteristics in the adult stage, is widespread in newts and salamanders and is suspected to play an important role in evolution. In some species, paedomorphosis is facultative with some individuals forgoing metamorphosis. Optimality models have been proposed to explain the maintenance of this polymorphism, but require the integration of reproductive patterns into the models. We investigated the frequencies of inbreeding and outbreeding in two syntopic heterochronic morphs of the Alpine newt. The two morphs are sexually compatible: encounters between and within morphs were equally successful in terms of spermatophore transfer. Behavioural observations were in agreement with the sexual compatibility observed. Nevertheless, paedomorphic males displayed to females less frequently than metamorphic males. The two morphs differ largely on the basis of sexual secondary characteristics, but the majority of these traits did not affect mating success. Because of the large flow of genes between the two heterochronic morphs and because of the absence of spatial and temporal isolation, these results do not support sympatric speciation models, but are in favour of the maintenance of polymorphism in natural populations. (C) 2001 The Association for the Study of Animal Behaviour. [less ▲]

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See detailTraçabilité dans la filière viande. I. La traçabilité administrative.
Evrard, V.; China, B.; Noirfalise, R. et al

in Annales de Médecine Vétérinaire (2001), 145

Le secteur de la viande a été secoué ces dernières années par quelques scandales, tels ceux des hormones et de la dioxine, avec pour conséquences une perte de confiance de la part du consommateur et une ... [more ▼]

Le secteur de la viande a été secoué ces dernières années par quelques scandales, tels ceux des hormones et de la dioxine, avec pour conséquences une perte de confiance de la part du consommateur et une perturbation du marché de la viande. Pour redresser l’image des produits carnés belges, il est important de pouvoir en déterminer et en garantir l’origine. En Belgique, il existe divers systèmes de traçabilité administrative dont le principal est le système SANITEL qui comprend un système automatisé de traitement de données relatives à l’identification et l’enregistrement des animaux. Au-delà de l’aspect légal et réglementaire, différentes initiatives, visant une amélioration de la qualité, fleurissent : "les labels". Ceux-ci intègrent fréquemment la traçabilité dans leur cahier des charges. La traçabilité administrative n’est pas infaillible, la perte de documents et les fraudes peuvent ternir l’image de celle-ci. C’est pourquoi le système documentaire a été associé aux empreintes génétiques des animaux. 5 [less ▲]

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See detailImmunisation against East Coast fever by the infection and treatment method: evaluation of the use of ice baths for field delivery and appraisal of an acid formulation of long-acting tetracycline.
Marcotty, T.; Billiouw, M.; Chaka, G. et al

in Veterinary Parasitology (2001), 99(3), 175-87

Immunisation by the infection and treatment method using the Katete strain is currently the most efficient prophylactic technique to control East Coast fever (ECF) in the endemic areas of the Eastern ... [more ▼]

Immunisation by the infection and treatment method using the Katete strain is currently the most efficient prophylactic technique to control East Coast fever (ECF) in the endemic areas of the Eastern Province of Zambia. The maintenance of the cold chain in liquid nitrogen up to the time of inoculation and the cost of the reference long-acting oxytetracycline (Terramycin LA, Pfizer) are the main drawbacks of the method. The work presented in this paper aims at reducing the cost of immunisation against ECF by using an ice bath for the field delivery and a cheaper long-acting oxytetracycline formulation as chemotherapeutic agent. In experimental conditions, the results from 40 calves immunised after various periods of storage on ice ranging from 4 to 32 h indicate that deferred immunisation performed with a stabilate kept on ice for up to 6h after thawing has an efficiency of 90%. Moreover, sporozoites kept on ice were still surviving 32 h after thawing. In a field trial, 91 calves were inoculated with a stabilate kept for 3.5-5.5 h after thawing and dilution whereas 86 calves were immunised using the standard method. Clinical and parasitological reactions to immunisation were monitored as well as the seroconversion. In the field trial, the deferred immunisation was more efficient than the standard method. The acid formulation of oxytetracycline that was tested was found as suitable as the reference alkaline formulation for the chemotherapeutic control of the Katete strain in ECF immunisation. One indoor trial was carried out on 10 animals and a field trial involved 93 calves. [less ▲]

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See detailPalaeogeographic and palaeoenvironmental characteristics of major marine incursions in northwestern Europe during the Westphalian C (Bolsovian).
Dusar, M; Paproth, E; Streel, Maurice ULg et al

in Geologica Belgica (2001), (2000)3(3-4), 331-347

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See detailL'impact de la readaptation cardiaque sur la qualite de vie apres un pontage aorto-coronaire : Une etude belge
Etienne, Anne-Marie ULg; Fontaine, Ovide ULg; Dupuis, Gilles et al

in Revue Francophone de Clinique Comportementale et Cognitive (2001), 6(2), 15-25

The aim of this study was to measure the quality of life of coronary artery bypass surgery patients enrolled or not in a rehabilitation program. The study was prospective and longitudinal and used ... [more ▼]

The aim of this study was to measure the quality of life of coronary artery bypass surgery patients enrolled or not in a rehabilitation program. The study was prospective and longitudinal and used patients’ self selection as the allocation strategy to constitute the two groups: rehabilitation and no-rehabilitation. Forty first coronary bypass surgery patients (38 men and 2 women, mean age 59 +/-8) were recruited from four hospitals in a French area of Belgium. Patients were evaluated before and after surgery with: the Quality of Life Systemic Inventory (QLSI), the Beck Depression Inventory, the State Anxiety Inventory, a somatic symptoms questionnaire, a physical activities questionnaire, and a medical questionnaire. Both groups improved on the QLSI global score of quality of life, but the effect size (eta squared) was greater in the rehab group (0.5) compared to the no rehab group (0.25) [less ▲]

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See detailQuelle réparation de l'accident de travail mortel est-elle réservée au concubin? Une réponse attendue de la Cour d'Arbitrage.
Michiels, Olivier ULg; Joskin, Véronique

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

Cette note aborde la quesiton suivante : L'article 12 de la loi du 12 avril 1971 relative aux accidents du travail viole-t-il les articles 10 et 11 de la Constitution en ce qu'il réserve le bénéfice d'une ... [more ▼]

Cette note aborde la quesiton suivante : L'article 12 de la loi du 12 avril 1971 relative aux accidents du travail viole-t-il les articles 10 et 11 de la Constitution en ce qu'il réserve le bénéfice d'une rente viagère au conjoint ni divorcé, ni séparé de corps ainsi qu'au conjoint divorcé ou séparé de corps qui bénéficiait d'une pension alimentaire à charge de la victime ? [less ▲]

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See detailErosion of Deccan Traps determined by river geochemistry: impact on the global climate and the Sr-87/Sr-86 ratio of seawater
Dessert, C.; Dupre, B.; François, Louis ULg et al

in Earth And Planetary Science Letters (2001), 188(3-4), 459-474

The impact of the Deccan Traps on chemical weathering and atmospheric CO2 consumption on Earth is evaluated based on the study of major elements, strontium and Sr-87/Sr-86 isotopic ratios of the main ... [more ▼]

The impact of the Deccan Traps on chemical weathering and atmospheric CO2 consumption on Earth is evaluated based on the study of major elements, strontium and Sr-87/Sr-86 isotopic ratios of the main rivers flowing through the traps, using a numerical model which describes the coupled evolution of the chemical cycles of carbon. alkalinity and strontium and allows one to compute the variations in atmospheric pCO(2), mean global temperature and the Sr-87/Sr-86 isotopic ratio of seawater, in response to Deccan trap emplacement. The results suggest that the rate of chemical weathering of Deccan Traps (21-63 t/km(2)/yr) and associated atmospheric CO consumption (0.58-2.54 x 10(6) mol C/km(2)/yr) are relatively high compared to those linked to other basaltic regions. Our results on the Deccan and available data from other basaltic regions show that runoff and temperature are the two main parameters which control the rate of CO2 consumption during weathering of basalts, according to the relationship: f = R-f x C(0)exp[-Ea/R(1/T-1/298)] where f is the specific CO2 consumption rate (mol/km(2)/yr), R-f is runoff (mm/yr), C-0 is a constant (= 1764 mu mol/l), Ea represents an apparent activation energy for basalt weathering (with a value of 42.3 kJ/mol determined in the present study), R is the gas constant and T is the absolute temperature (K-o). Modelling results show that emplacement and weathering of Deccan Traps basalts played an important role in the geochemical cycles of carbon and strontium. In particular, the traps led to a change in weathering rate of both carbonates and silicates, in carbonate deposition on seafloor, in Sr isotopic composition of the riverine flux and hence a change in marine Sr isotopic composition. As a result, Deccan Traps emplacement was responsible for a strong increase of atmospheric pCO(2) by 1050 ppmv followed by a new steady-state pCO(2) lower than that in pre-Deccan times by 57 ppmv, implying that pre-industrial atmospheric pCO(2) would have been 20% higher in the absence of Deccan basalts. pCO(2) evolution was accompanied by a rapid warming of 4 degreesC, followed after 1 Myr by a global cooling of 0.55 degreesC. During the warming phase, continental silicate weathering is increased globally. Since weathering of continental silicate rocks provides radiogenic Sr to the ocean, the model predicts a peak in the Sr-87/Sr-86 ratio of seawater following the Deccan Traps emplacement. The amplitude and duration of this spike in the Sr isotopic signal are comparable to those observed at the Cretaceous-Tertiary boundary. The results of this study demonstrate the important control exerted by the emplacement and weathering of large basaltic provinces on the geochemical and climatic changes on Earth. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailSymptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study.
Appelboom, T; Schuermans, J; Verbruggen, G et al

in Scandinavian Journal of Rheumatology (2001), 30(4), 242-7

OBJECTIVES: We compare the symptomatic effects of 300 or 600mg daily of ASU in patients with knee osteoarthritis. METHODS: A multicenter, double blind, study comparing a daily intake of 300mg or 600mg of ... [more ▼]

OBJECTIVES: We compare the symptomatic effects of 300 or 600mg daily of ASU in patients with knee osteoarthritis. METHODS: A multicenter, double blind, study comparing a daily intake of 300mg or 600mg of ASU and placebo. The study lasted 3 months and involved patients of both genders, aged 45 to 80 years and presenting with femoro-tibial knee osteoarthritis. The primary endpoint was NSAIDs and analgesics intake between D30 and D90. RESULTS: All efficacy parameters were significantly improved (p<0.01), in the two ASU groups compared to the placebo group. At D90, NSAIDs and analgesics intake decreased by more than 50% in 71% of the patients receiving ASU 300mg or 600mg, compared to 36% of the patients receiving placebo. From DO to D90 Lequesne's index dropped by 3.9 and 2.9 points in ASU 300mg and 600mg groups, respectively, against 1.6 in those receiving placebo. CONCLUSION: The efficacy of ASU at a dosage of 300mg/day and 600mg/day was consistently superior to that of placebo at all endpoints, with no differences observed between the two doses. [less ▲]

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See detailL'etude clinique du mois. L'etude CALM ou interet de combiner un inhibiteur de l'enzyme de conversion et un antagoniste du recepteur de type 1 de l'angiotensine II dans le traitement de la nephropathie diabetique.
Philips, Jean-Christophe ULg; Weekers, Laurent ULg; Scheen, André ULg

in Revue Médicale de Liège (2001), 56(2), 126-8

The main objective of the CALM (Candesartan And Lisinopril Microalbuminuria) study is to assess the effect of a dual blockade of the renin-angiotensin system--using both an angiotensin converting enzyme ... [more ▼]

The main objective of the CALM (Candesartan And Lisinopril Microalbuminuria) study is to assess the effect of a dual blockade of the renin-angiotensin system--using both an angiotensin converting enzyme inhibitor (ACE-I) and an angiotensin II type 1 receptor blocker--in patients with type 2 diabetes, high blood pressure and microalbuminuria. The study included 200 patients randomized to receive candesartan 16 mg or lisinopril 20 mg for 12 weeks, followed by 12 weeks of the same monotherapy or a combination treatment. Main outcomes are the reduction of microalbuminuria and blood pressure. All three of the treatments are effective, but the dual blockade is respectively 18%, 8 mmHg and 5 mmHg more effective in reducing microalbuminuria, systolic and diastolic blood pressure. No comparison is made between this "new" association and the more frequently used biotherapy (i.e. ACE-I plus thiazidic diuretic) and therefore its usefulness in regular practice is still to be determined. [less ▲]

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