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See detailEnzymatically prepared n-alkyl esters of glucuronic acid: The effect of hydrophobic chain length on surface properties
Blecker, Christophe ULg; Piccicuto, S.; Lognay, Georges ULg et al

in Journal of Colloid & Interface Science (2002), 247(2), 424-428

The effect of hydrophobic chain length on surface properties of enzymatically prepared n-alkyl esters of glucuronic acid are examined. Dynamic parameters from Hua and Rosen's mathematical model and ... [more ▼]

The effect of hydrophobic chain length on surface properties of enzymatically prepared n-alkyl esters of glucuronic acid are examined. Dynamic parameters from Hua and Rosen's mathematical model and equilibrium surface tension are presented for esters with octyl, decyl, dodecyl, and tetradecyl alkyl segments. Increasing the alkyl chain length has a significant influence on the surface activity. Decyl and dodecyl glucuronate exhibit an interesting adsorption speed associated with foaming capacity. Octyl glucuronate exhibits a micellar organization as its bulk concentration is over 10.68 mM. (C) 2002 Elsevier Science (USA). [less ▲]

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See detailGamma-probe-directed lymphatic mapping and sentinel lymphadenectomy in primary cutaneous melanoma.
Belhocine, T.; Pierard, Gérald ULg; Gielen, Jean-Louis ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(4), 355-61

BACKGROUND: Radiotracer and blue-dye lymphatic mapping is a recommended combined method to guide sentinel lymphadenectomy and full regional lymph node dissection in selected patients with cutaneous ... [more ▼]

BACKGROUND: Radiotracer and blue-dye lymphatic mapping is a recommended combined method to guide sentinel lymphadenectomy and full regional lymph node dissection in selected patients with cutaneous melanoma. OBJECTIVE: To evaluate the diagnostic accuracy and the prognostic value of gamma-probe-directed lymphatic mapping in cutaneous melanomas. METHODS: Sixty-five stage I and II melanoma patients underwent gamma-probe-directed lymphatic mapping. Sentinel lymph nodes were studied by both conventional and immunohistochemical stainings. The median follow-up was 11 months. RESULTS: Sensitivities of preoperative and intraoperative sentinel lymph node detection were 100 and 98%, respectively. Only 1 failure of detection and 1 missed same-basin metastasis were experienced in the axillary and cervical areas, respectively. Eleven patients (16.9%) had sentinel node metastases leading to adjuvant therapy. CONCLUSION: Gamma-probe-directed lymphatic mapping is useful for staging melanoma. However, in the expectation of a more specific identification of the sentinel lymph node, the standard protocol remains recommended for exploring the axillary and cervical areas. The histological examination supported in some cases by immunohistochemistry remains mandatory in all cases. [less ▲]

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See detailUse of Anesthesia Simulator
Pendeville, Philippe; Mayne, Alain; LARBUISSON, Robert ULg et al

in Benelux quaterly journal on automatic control (2002), 43(2), 17-19

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See detailEuro- en zijn concurrenten
Meesters, Gert ULg

in Leuvense Bijdragen (2002), 91(1-2), 79-96

This article deals with the Dutch bound morpheme euro-, meaning ‘European’ or ‘Europe’ in relatively young word formations. The morpheme in question is not to be confounded with the word euro for the ... [more ▼]

This article deals with the Dutch bound morpheme euro-, meaning ‘European’ or ‘Europe’ in relatively young word formations. The morpheme in question is not to be confounded with the word euro for the European currency. The article especially deals with the relationship between word formation with euro- and three other means of expressing more or less the same meaning: word formation with EG- (abbreviation of Europese Gemeenschap, i.e. European Union) as a first component, word formation with Europa- (Europe) as a first component and word groups with the adjective Europees (European). This relationship is explored in two comparative studies. First the token frequency in a corpus is investigated. It turns out that euro- is more frequent than Europa-, but less frequent than EG- and Europees. In a second comparison the semantic-functional domains of the four alternatives are considered in detail. Euro- apparently can be used as an alternative for Europees and EG- when the referents are related to the European Union, and as an alternative for Europees in ‘bilateral’ adjectives such als Euro-Russisch. It also has a few domains of its own: commercial proper names and words expressing an attitude towards the European Union. An additional analysis of individual words and word groups with different alternatives from this paradigm as a first component but the same second component reveals that even in individual cases of competition with other alternatives, the variant with euro- is sometimes the most frequent or the institutionalized form. It is concluded that within the linguistic potential of naming referents that relate to Europe, euro- has its own specific value as a productive means of word formation. [less ▲]

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See detailWilliam S. Burroughs: Du cut-up au simulacre
Claisse, Frédéric ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2002), (94-95-96), 151-174

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See detailModelled glacial and non-glacial HCO3-, Si and Ge fluxes since the LGM: little potential for impact on atmospheric CO2 concentrations and a potential proxy of continental chemical erosion, the marine Ge/Si ratio
Jones, Ian W; Munhoven, Guy ULg; Tranter, Martyn et al

in Global and Planetary Change (2002), 33(1-2), 139-153

The runoff and riverine fluxes of HCO3-, Si and Ge that arise from chemical erosion in non-glaciated terrain, are modelled at six time steps from the Last Glacial Maximum (LGM) to the present day. The ... [more ▼]

The runoff and riverine fluxes of HCO3-, Si and Ge that arise from chemical erosion in non-glaciated terrain, are modelled at six time steps from the Last Glacial Maximum (LGM) to the present day. The fluxes that arise from the Great Ice Sheets are also modelled. Terrestrial HCO3- fluxes decrease during deglaciation, largely because of the reduction in the area of the continental shelves as sea level rises. The HCO3- fluxes. and the inferred consumption of atmospheric CO2 are used as inputs to a carbon cycle model that estimates their impact on atmospheric CO2 concentrations ((CO2)-C-atms). A maximum perturbation of (CO2)-C-atms by similar to 5.5 ppm is calculated, The impact of solutes from glaciated terrain is small in comparison to those from non-glaciated terrain. Little variation in terrestrial Si and Ge fluxes is calculated (< 10%). However, the global average riverine Ge/Si ratio may be significantly perturbed if the glacial Ge/Si ratio is high. At present. variations in terrestrial chemical erosion appear to have only a reduced impact on (CO2)-C-atms and only little influence on the global Si and Ge cycle and marine Ge/Si ratios during deglaciation. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailInventories and Maps: Cognitive Ways of Framing the Nature Policies in Europe
Mougenot, Catherine ULg; Remy, Elisabeth

in Journal of Environmental Policy & Planning (2002), 4(4), 313-322

Since the Earth Summit in Rio, declining biodiversity has become a subject of general concern for many countries. To counter these negative trends, government nature policies in Europe at least are now ... [more ▼]

Since the Earth Summit in Rio, declining biodiversity has become a subject of general concern for many countries. To counter these negative trends, government nature policies in Europe at least are now thought out primarily in terms of networks. They concern new areas outside nature reserves, new players and new management strategies. Consequently, these policies should themselves become the subject of new public debate. Our study concerns the analysis of the forms used to collect the data required to set up the European Union's Natura 2000 network and maps drawn as part of the Council of Europe's Pan-European Ecological Network strategy. The aim of this article, which takes the perspective developed by the sociology of science, will be to show how the forms and maps used in these new nature policies produce knowledge that precedes policy discussions to search for the best possible socio-political compromises. In other words, the knowledge that is collected in and by means of these documents, forms and maps offers a cognitive way of framing the subsequent public debates. [less ▲]

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See detailMechanical behaviour of Lixhe chalk partly saturated by oil and water: experiment and modelling
Collin, Frédéric ULg; Cui, Yu Jun; Schroeder, Christian ULg et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2002), 26(9), 897-924

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical ... [more ▼]

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical behaviour of a chalk saturated by two non-miscible fluids, water and oil. The effects of the capillary pressure or suction are taken into account. They are considered as an independent variable, as in the Barcelona's basic model developed for unsaturated soils. On the other hand, internal friction and pore collapse are modelled as independent mechanisms. The determination of the parameters is based on triaxial and oedometer tests. Finally, in order to validate the model, predictions are compared with experimental results of water-flooding test. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailRadiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.
Egger, J-F; Coindre, J-M; Benhattar, J et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2002), 15(9), 998-1004

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant ... [more ▼]

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004 [less ▲]

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See detailPre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.
Baron, Frédéric ULg; Siquet, Jean; Schaaf-Lafontaine, Nicole ULg et al

in Haematologica (2002), 87(1), 78-88

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood ... [more ▼]

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood stem cell (PBSC) transplantation followed by CD8-depleted donor lymphocyte infusion (DLI). DESIGN AND METHODS: Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2 x 10(6), 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 14-24). The 1st aliquot was infused on day 60 and the other 1 (2) cryopreserved and infused on days 100 (and 140). RESULTS: An average of 100%, 100% and 84% of the scheduled dose could be administered in DLI 1, 2 and 3, respectively. Although the study group was at very high risk of GVHD, the actuarial incidence of grade II-IV acute GVHD was 28% (13% for HLA-identical siblings) with only 1 patient developing grade III-IV GVHD (after DLI). The actuarial 2-year probability of extensive chronic GVHD was similarly low (13% for all patients and 0% for HLA-identical siblings). Individual cases as well as a 30% relapse rate (0% for standard-risk patients versus 55% for high-risk patients) indicated preservation of the GVL effect. INTERPRETATION AND CONCLUSIONS: We conclude that allogeneic transplantation of CD34-selected PBSC followed by pre-emptive CD8-depleted DLI is feasible with rapid engraftment and minimizes the risk of severe GVHD. Large prospective trials are required to prove that it preserves the GVL effect fully. [less ▲]

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See detailRunoff control of soil degassing at an active volcano. The case of Piton de la Fournaise, Reunion Island
Toutain, J. P.; Baubron, J. C.; François, Louis ULg

in Earth And Planetary Science Letters (2002), 197(1-2), 83-94

Airborne atmospheric and in-situ soil gas analyses demonstrate that distal gas leaks are non-existent at Piton de la Fournaise (PF) despite frequent eruptions. Airborne traverses made at a constant ... [more ▼]

Airborne atmospheric and in-situ soil gas analyses demonstrate that distal gas leaks are non-existent at Piton de la Fournaise (PF) despite frequent eruptions. Airborne traverses made at a constant altitude indicated that no detectable large-scale CO2 degassing occurs from the volcano. In-situ soil gas traverses (CO2, He-4, Rn-222) across the active riftzones, the summit crater and the caldera rims, show both a lack of positive anomalies and evidence of strong depleted concentrations for He and CO2 with respect to air. Depletions in soil He is explained by intense rain water infiltration. A more unexpected result lies in the very low CO2 concentrations (down to 92 ppm) in bare soils in the summit region. Such a depletion was not previously reported and is attributed to considerable basalt weathering operating as the result of huge runoff. A model has enabled both the runoff and the CO2 consumption occurring within the basaltic layers to be calculated. Data obtained are consistent with values expected from large-scale erosion models and with the local calculated diffusive flux of CO2 in soils. The huge runoff, together with the basaltic lithology of the volcano, are found to be the main factor controlling the soil gas signatures at PF. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailQualité et action publique
Mormont, Marc ULg

in Pyramides (2002), 5

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See detailQuantitative dilatometric analysis of intercritical annealing in a low-silicon TRIP steel
Zhao, Lie; Kop, T. A.; Rolin, Valéry et al

in Journal of Materials Science (2002), 37

In this work, an evaluation method to calculate the austenite fraction during continuous heating and isothermal annealing from dilatometric data is proposed. By means of a single reference measurement to ... [more ▼]

In this work, an evaluation method to calculate the austenite fraction during continuous heating and isothermal annealing from dilatometric data is proposed. By means of a single reference measurement to determine a scaling factor correcting for experimental errors, a framework is created to determine the austenite fraction as a function of time and temperature. In the evaluation of the dilatometric data the effect of the changing carbon concentration in austenite phase is taken into account. The method is applied to dilatometric data for a 0.16C-1.5Mn-0.4Si (wt%) low-silicon transformation induced plasticity (TRIP) multiphase steel. Three typical dilatometric data are obtained by heating the material to 750°C, 800°C or 900°C, which leads to three different microstructures consisting of (1) ferrite, cementite and austenite, (2) ferrite and austenite and (3) full austenite, respectively. The calculated results using the proposed new method are compared with the results from thermodynamic analysis and those from quantitative microscopic analysis. Significant inter-test discrepancies are observed. [less ▲]

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See detailPreemptive cellular immunotherapy after T-cell-depleted allogeneic hematopoietic stem cell transplantation.
Baron, Frédéric ULg; Beguin, Yves ULg

in Biology of Blood & Marrow Transplantation (2002), 8(7), 351-9

GVHD is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is due to donor lymphocytes that are cotransplanted with donor stem cells. These donor ... [more ▼]

GVHD is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is due to donor lymphocytes that are cotransplanted with donor stem cells. These donor lymphocytes are primed by histocompatibility differences between donors and recipients and activated by a cytokine storm caused by the conditioning regimen. The most efficient method for prevention of GVHD consists of T-cell depletion (TCD) of the graft. However, TCD usually leads to an increased risk of leukemia relapse because of the loss of the graft-versus-leukemia (GVL) effect. Several groups have studied the feasibility of preemptive donor lymphocyte infusion (DLI) to lessen the impact of TCD on leukemia relapse. Preemptive DLI is given several weeks to months after the transplantation, ie, after the cytokine storm and after the patient has recovered from conditioning-regimen-related toxicities. After briefly discussing various techniques of TCD of the graft and the efficacy of DLI, this article reviews the first clinical studies evaluating a strategy of TCD of the graft followed by preemptive DLI. [less ▲]

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See detailSmearing scheme for finite-temperature electronic-structure calculations
Verstraete, Matthieu ULg; Gonze, X.

in Physical Review. B : Condensed Matter (2002), 65

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See detailAphid prey suitability as environmental effect on Adalia bipunctata reproduction.
Vanhaelen, Nicolas; Gaspar, Charles ULg; Francis, Frédéric ULg

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2002), 67(3), 563-8

Secondary plant metabolites (allelochemicals) play a major role in plant-insect interactions. Glucosinolates (GLS) and their degradation products from Brassica species are attractants and feeding ... [more ▼]

Secondary plant metabolites (allelochemicals) play a major role in plant-insect interactions. Glucosinolates (GLS) and their degradation products from Brassica species are attractants and feeding stimulants for Brassicaceae specialist insects but are generally repellent and toxic for generalist herbivores. The impact of these compounds on crucifer specialist insects are well known but their effect on generalist predators is still not well documented. Prey host plant influence on reproduction of an aphidophagous beneficial, the two spot ladybird, was determined using the cabbage aphid, Brevicoryne brassicae reared on a crucifer plant, namely Brassica napus containing low GLS levels. As ladybird developmental and reproductive parameters were already shown to be strongly affected by the allelochemical presence in its preys, the unsuitable aphid and host plant combination was only momentary used to feed the A. bipunctata adults. A strong impact of the diet was observed on the beetle fecundity and the emerging offspring. Changing B. brassicae aphid to a suitable prey slowly improved the temporary negative effect of the former diet. These results enhance the food environmental effect and the importance of tritrophic relations in pest management strategies by predators. Indeed, more than the choice of the beneficial species, the prey host plant has a major influence on the potential efficacy of biological agent to control herbivore species such as aphids. [less ▲]

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See detailSynthesis of peptide-modified pyoverdins by a fluorescent Pseudomonas strain grown in isoleucine-supplemented medium
Ongena, MARC ULg; Jacques, Philippe ULg; De Pauw, Edwin ULg et al

in Letters in Peptide Science (2002), 8(1), 21-27

The pattern of pyoverdin-type siderophores produced by Pseudomonas putida BTP16 in iron-limited succinate medium supplemented or not with isoleucine was characterized by electrospray ionization mass ... [more ▼]

The pattern of pyoverdin-type siderophores produced by Pseudomonas putida BTP16 in iron-limited succinate medium supplemented or not with isoleucine was characterized by electrospray ionization mass spectrometry. Two new compounds were observed in culture supernatants from BTP16 grown in the presence of isoleucine. For both molecules, mass differences with pyoverdins originally synthesized by the strain were only interpreted considering the incorporation of Ile into the peptide chain. Further evidence supporting this phenomenon was provided by radioactivity incorporation in pyoverdins produced in the presence of C-14-labeled Ile. Our results are discussed in relation to the non-ribosomal mechanism supposed to be involved in the synthesis of these molecules. [less ▲]

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See detailGeneralized Fourier equations and thermoconvective instabilities
Dauby, Pierre ULg; Nelis, M.; Lebon, Georgy ULg

in Revista Mexicana De Fisica (2002), 48(Suppl. 1), 57-62

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See detailThe intracellular tyrosine residues of the ATP-gated P2X(1) ion channel are essential for its function.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Watanabe, Hiroyuki et al

in FEBS Letters (2002)

In this study, we mutated the four highly conserved intracellular tyrosine residues of the P2X(1) ion channel were mutated into phenylalanine. Simultaneous electrophysiological and calcium measurements in ... [more ▼]

In this study, we mutated the four highly conserved intracellular tyrosine residues of the P2X(1) ion channel were mutated into phenylalanine. Simultaneous electrophysiological and calcium measurements in transfected human embryonic kidney (HEK 293) cells indicated that Y362F and Y370F mutants were non-functional, despite their proper plasma membrane expression. The Y16F and Y363F mutants retained 2.2% and 26% of the wild-type P2X(1) activity, respectively. However, no tyrosine phosphorylation was detected on Western blots of P2X(1) immunoprecipitates derived either from HEK 293 cell lysates or from human platelets, expressing P2X(1) endogenously. Thus, Y16, Y362, Y363 and Y370 are required for the appropriate three-dimensional structure and function of the intracellular P2X(1) domains. [less ▲]

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See detailSubcellular Localization Of The Bovine Leukemia Virus R3 And G4 Accessory Proteins
Lefebvre, Laurent; Ciminale, Vincenzo; Vanderplasschen, Alain ULg et al

in Journal of Virology (2002), 76(15), 7843-7854

Bovine leukemia virus (BLV) is a complex retrovirus that belongs to the Deltaretrovirus genus, which also includes Human T-cell leukemia virus type 1 (HTLV-1). Both viruses contain an X region coding for ... [more ▼]

Bovine leukemia virus (BLV) is a complex retrovirus that belongs to the Deltaretrovirus genus, which also includes Human T-cell leukemia virus type 1 (HTLV-1). Both viruses contain an X region coding for at least four proteins: Tax and Rex, which are involved in transcriptional and posttranscriptional regulation, respectively, and the accessory proteins R3 and G4 (for BLV) and p12(I), p13(II), and p30(II) (for HTLV-1). The present study was aimed at characterizing the subcellular localization of BLV R3 and G4. The results of immunofluorescence experiments on transfected HeLa Tat cells demonstrated that R3 is located in the nucleus and in cellular membranes, as previously reported for HTLV-1 p12(1). In contrast, G4, like p13(II), is localized both in the nucleus and in mitochondria. In addition, we have shown that G4 harbors a mitochondrial targeting signal consisting of a hydrophobic region and an amphipathic alpha-helix. Thus, despite a lack of significant primary sequence homology, R3 and p12(1) and G4 and p13(II) exhibit similar targeting properties, suggesting possible overlap in their functional properties. [less ▲]

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See detailLe vers semi-libre d'Yves Bonnefoy dans 'Ce qui fut sans lumiere'
Purnelle, Gérald ULg

in Français Moderne (Le) (2002), 70(2), 145-168

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See detailEvidence of an equilibrium between selenides and osmium(VIII) reagents and selenoxides and osmium(VI) reagents
Krief, A.; Destree, A.; Durisotti, V. et al

in Chemical Communications (2002), (6), 558-559

Driving the equilibrium between selenides and osmium( VIII) reagents with selenoxides and osmium( VI) by a subsequent reaction (rearrangement of allyl selenoxides to allyl alcohols or addition of osmium ... [more ▼]

Driving the equilibrium between selenides and osmium( VIII) reagents with selenoxides and osmium( VI) by a subsequent reaction (rearrangement of allyl selenoxides to allyl alcohols or addition of osmium( VIII) species on C C double bonds) to one side, allows the transformation of methyl geranyl selenides to linalool and of methyl citronellyl selenoxide to 6,7-dihydroxy citronellyl selenide. [less ▲]

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See detailMons/Maisières : nouvelle occupation paléolithique au site de Maisières-Canal
Miller, Rebecca ULg; Guillaume, Alain; Otte, Marcel ULg

in Chronique de l'Archéologie Wallonne (2002), 10

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See detailImpact of closed habitat on the entomological diversity and abundance in carrot open fields
Colignon, Pierre; Gaspar, Charles; Haubruge, Eric ULg et al

in Med. Fac. Landbouw. Univ. Gent (2002), 67(3), 481-486

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See detailL'image du mois. Une onychopathie ponctuée en dé a coudre.
Perotti-Abad, M. J.; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(3), 129-30

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See detailIsolement et caractérisation de l'ostéocalcine équine
Carstanjen, Bianca; Wattiez, R.; Amory, Hélène ULg et al

in Annales de Médecine Vétérinaire (2002), 146

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the ... [more ▼]

Equine bone gamma-carboxyglutamic acid containing protein - also called osteocalcin - has been isolated for the first time till homogeneity. After acid demineralisation and acid extraction, the purification procedure was based on reverse phase chromatography, gel filtration and ion exchange chromatography. The amino acid sequence of the primary structure has been determined to be YLDHWLGA(HYP) APYPDPL(GLA)PRR(GLA)VC (GLA)LNPDCDELADHIGF-AYRRFYGPV. The protein has a calculated molecular weight of 5,732 kDa and a calculated isoelectric point of 4,45. It contains 49 amino acids, from which 3 are gamma-carboxyglutamic acid residues at position 17, 21 and 24 and has a fully hydroxylated proline in position nine and cysteine in position 23 and 29. Equine osteocalcin shows a strong homology with bovine (98%), ovine (96%) and human (94%) osteocalcin [less ▲]

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See detailAdult mullerian duct or utricle cyst: clinical significance and therapeutic management of 65 cases.
Coppens, Luc ULg; Bonnet, Pierre ULg; Andrianne, Robert ULg et al

in Journal of Urology (The) (2002), 167(4), 1740-4

PURPOSE: We define guidelines for the exploration and treatment of adult mullerian duct cysts. MATERIALS AND METHODS: From January 1988 through September 1999 a diagnosis of enlarged prostatic utricle was ... [more ▼]

PURPOSE: We define guidelines for the exploration and treatment of adult mullerian duct cysts. MATERIALS AND METHODS: From January 1988 through September 1999 a diagnosis of enlarged prostatic utricle was made in 65 adults based on transrectal ultrasound findings. Echographic criteria to define simple versus complicated cysts were detailed. We reviewed the clinical presentation, diagnostic modalities, indications for invasive procedures and postoperative outcome. RESULTS: The usual clinical presentations were hematospermia in 40% of cases, other ejaculatory disturbances in 20%, recurrent testicular or pelviperineal pain in 33%, lower urinary tract irritation symptoms in 25%, lower urinary tract infection in 18.5%, male infertility in 12% and incidental finding in 18.5%. Cyst dimensions did not influence the indication for invasive procedures, which were performed in only 27 of the 65 patients (41.5%) to treat disabling symptoms in 28% and obstructive infertility in 5%, and investigate complicated cysts on transrectal ultrasound in 6%. These procedures included transperineal or transrectal puncture in 9 patients, simple endoscopic section of the utricle meatus in 12 and large marsupialisation in 6. Complete and sustained cure was noted in half of the patients treated with cyst puncture only, although echographic relapse was the rule. Endoscopic procedures definitely improved or cured 82% of the patients at a mean followup of 51 months, during which neither early nor late complications were noted. CONCLUSIONS: Since almost 60% of adults diagnosed with a mullerian duct cyst did not experience any cyst related symptoms or ejaculatory-fertility impairment, we recommend that investigation and/or treatment should only be done in symptomatic or infertile patients. [less ▲]

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See detailA transformed fish cell line expressing a green fluorescent protein-luciferase fusion gene responding to cellular stress
Molina, A.; Carpeaux, Rudy ULg; Martial, Joseph ULg et al

in Toxicology in Vitro (2002), 16(2), 201-7

We obtained a stable transformed fish (EPC) cell line containing a reporter gene under the control of the tilapia HSP70 promoter. Expression of the reporter gene, coding for a green fluorescent protein ... [more ▼]

We obtained a stable transformed fish (EPC) cell line containing a reporter gene under the control of the tilapia HSP70 promoter. Expression of the reporter gene, coding for a green fluorescent protein (GFP)-luciferase fusion protein, was assessed by measuring the luciferase enzymatic activity by luminometry and the GFP expression by fluorescence microscopy and flow cytometry. The clone was characterized for its capacity to respond to heat shock treatment. The results show high induction after 1 h at 37 degrees C of treatment, up to 500-fold. In addition, its convenience to detect a large range of cellular stressors was evaluated. We observed high induction when Cd2+, Zn2+, Hg2+ or Cu2+ was added, but not Pb2+. In addition, activation of the reporter gene was observed in the presence of other compounds such as acetyl chloride, tetrachlorophenol, chloroacetamide and sodium arsenite. In conclusion, this cell line can be used as a rapid, cheap and easy biological test to determine cellular stress induced by environmental pollutants, alone or in conjunction with other, more specific assays. [less ▲]

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See detailPharma clinics. Comment je traite ... un herpes labial récurrent.
Petit, L.; Braham, C.; Nikkels, Arjen ULg et al

in Revue Médicale de Liège (2002), 57(2), 67-71

Recurrent herpes labialis is a frequent disorder. It occurs following the reactivation of the Herpesvirus (HSV1 and more rarely HSV2) inside the Gasser ganglion. Treatment and prevention of recurrent ... [more ▼]

Recurrent herpes labialis is a frequent disorder. It occurs following the reactivation of the Herpesvirus (HSV1 and more rarely HSV2) inside the Gasser ganglion. Treatment and prevention of recurrent labial herpes are targeted by specific antiviral agents. Spectacular benefits obtained in the immunocompromised patients are less convincing in otherwise healthy subjects. Other prospective ways of therapy are under consideration, including lipopeptides and physical means aiming at modifying the cutaneous pH. [less ▲]

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See detailLa guerre et la médecine d'une culture de paix. 4. Synopsis des armes nucléaires.
Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(2), 107-12

The nuclear weapons have a terrifying power of devastation. A civilian nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical ... [more ▼]

The nuclear weapons have a terrifying power of devastation. A civilian nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical consequences. The Gulf war and Balkan war syndromes might be in part caused by uranium used in conventional amunitions. The risk of nuclear terrorism is an emerging eventuality. [less ▲]

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See detailPosidonia Oceanica Meadow: A Low Nutrient High Chlorophyll (LNHC) System?
Gobert, Sylvie ULg; Laumont, N.; Bouquegneau, Jean-Marie ULg

in BMC Ecology (2002), 2

BACKGROUND: In spite of very low nutrient concentrations in its vicinity - both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high biomass and productivity. We measured the ... [more ▼]

BACKGROUND: In spite of very low nutrient concentrations in its vicinity - both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high biomass and productivity. We measured the nutrient fluxes from the sediment into the water enclosed among the leaf shoots ("canopy water") to determine if it is possible source of nutrients for P. oceanica leaves. RESULTS: During the summer, the canopy water appears to act as a nutrient reservoir for the plant. During that period, the canopy water layer displays both a temperature 0.5 degrees C cooler than the upper water column, and a much higher nutrient content, as shown in this work using a very simple original technique permitting to sample water with a minimal disturbance of the water column's vertical structure.Despite low nutrient concentrations in pore water, mean net fluxes were measured from the sediment to the canopy water. These fluxes are sufficient to provide 20% of the mean daily nitrogen and phosphorus requirement of the P. oceanica shoots. CONCLUSION: An internal cycling of nutrients from P. oceanica senescent leaves was previously noted as an efficient strategy to help face low nutrient availability. The present study points out a second strategy which consists in holding back, in the canopy, the nutrients released at the water-sediment interface. This process occurs when long leaves, during poor nutrient periods in the water column, providing, to P. oceanica, the possibility to develop, high biomass, high chlorophyll quantities in low nutrient environment (a Low Nutrients High Chlorophyll system). [less ▲]

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See detailCa2+/calmodulin dependent protein kinase regulates GABA activated Cl- current in cockroach dorsal unpaired median neurons
Alix, Philippe ULg; Grolleau, F; Hue, B

in Journal of Neurophysiology (2002), 87

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in ... [more ▼]

We studied gamma-aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana using the whole cell patch-clamp technique in symmetrical chloride solutions. All DUM neurons voltage-clamped at -50 mV displayed inward currents (I(GABA)) when 10(-4) M of GABA was applied by pneumatic pressure-ejection pulses. The semi-logarithmic curve of I(GABA) amplitude versus the ejection time yielded a Hill coefficient of 4.0. I(GABA) was chloride (Cl-) because the reversal potential given by the current-voltage (I-V) curve varied according to the value predicted by the Nernst equation for Cl- dependence. In addition, I(GABA) was almost completely blocked by bath application of the chloride channel blockers picrotoxin (PTX) or 3,3-bis(trifluoromethyl)bicyclo-[2,2,1]heptane-2,2-diacarbonitrile (BIDN). The I-V curve for I(GABA) displayed a unexpected biphasic aspect and was best fitted by two linear regressions giving two slope conductances of 35.6 +/- 2.1 and 80.9 +/- 4.1 nS for potentials ranging from 0 to -30 and -30 to -70 mV, respectively. At -50 mV, the current amplitude was decreased by cadmium chloride (CdCl2, 10(-3) M) and calcium-free solution. The semi-logarithmic curve for CdCl2-resistant I(GABA) gave a Hill coefficient of 2.4. Hyperpolarizing voltage step from -50 to -80 mV was known to increase calcium influx through calcium-resting channels. According to this protocol, a significant increase of I(GABA) amplitude was observed. However, this effect was never obtained when the same protocol was applied on cell body pretreated with CdCl2. When the calmodulin blocker N-(6-aminohexyl)-5-chloro-1-naphtalene-sulfonamide or the calcium-calmodulin-dependent protein kinase blocker 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) was added in the pipette solution, I(GABA) amplitude was decreased. Pressure ejection application of the cis-4-aminocrotonic acid (CACA) on DUM neuron cell body held at -50 mV, evoked a Cl- inward current which was insensitive to CdCl2. The Hill plot yielded a Hill coefficient of 2.3, and the I-V curve was always linear in the negative potential range with a slope conductance of 32.4 +/- 1.1 nS. These results, similar to those obtained with GABA in the presence of CdCl2 and KN-62, indicated that CACA activated one subtype of GABA receptor. Our study demonstrated that at least two distinct subtypes of Cl--dependent GABA receptors were expressed in DUM neurons, one of which is regulated by an intracellular Ca2+-dependent mechanism via a calcium-dependent protein kinase. The consequences of the modulatory action of Ca2+ in GABA receptors function and their sensitivity to insecticide are discussed. [less ▲]

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See detailPetite réflexion sur la qualité du bois d'épicéa
Hebert, Jacques ULg; Herman, Marc; Jourez, Benoît ULg

in Forêt Wallonne (2002), (60), 24-25

En termes de qualité du bois, l'influence du sylviculteur est déterminante. En effet, dès la décision de plantation, et ensuite, par le jeu des soins culturaux et des éclaircies, il va façonner, compte ... [more ▼]

En termes de qualité du bois, l'influence du sylviculteur est déterminante. En effet, dès la décision de plantation, et ensuite, par le jeu des soins culturaux et des éclaircies, il va façonner, compte tenu des conditions environnementales, les caractéristiques de la matière première qui en définiront les aptitudes technologiques. [less ▲]

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See detailL'etude clinique du mois. Essais de preservation des cellules B a la phase initiale du diabete de type 1: resultats negatifs avec l'insuline retard, mais prometteurs avec un anticorps monoclonal anti-CD3.
Philips, Jean-Christophe ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(6), 413-7

Type 1 diabetes is an autoimmune disease leading to a progressive exhaustion of the insulin secretion and a destruction of the B-cells. Attempts of preservation of insulin-producing B-cells can be ... [more ▼]

Type 1 diabetes is an autoimmune disease leading to a progressive exhaustion of the insulin secretion and a destruction of the B-cells. Attempts of preservation of insulin-producing B-cells can be performed at an early, most often silent, stage of the disease in well-selected at high risk subjects or during the period immediately following the clinical diagnosis based upon classical signs of hyperglycaemia. In the "Diabetes Prevention Trial-Type 1", the prophylactic subcutaneous administration of low-dose ultralente insulin was not able to prevent the development of type 1 diabetes nor to preserve residual insulin secretion in young relatives at very high-risk of diabetes, selected upon genetic, immunological and metabolic criteria. In contrast, a pilot randomized trial shows that a treatment with a nonactivating humanized monoclonal antibody against CD3 mitigates the deterioration in insulin production and improves metabolic control, with lower dose of exogenous insulin, during the first year of type 1 diabetes mellitus in 9 out of 12 treated patients. Besides a better understanding of the natural history of the disease, these clinical trials open new perspectives for prevention of type 1 diabetes mellitus, currently assessed by the Belgian Diabetes Registry. [less ▲]

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See detailElectronic structure of thallium filled skutterudites studied by x-ray absorption and Mossbauer spectroscopy
Long, G. J.; Mahieu, B.; Sales, B. C. et al

in Journal of Applied Physics (2002), 92(12), 7236-7241

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4 ... [more ▼]

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4-yFeySb12 and TlxCo4Sb12-zSnz compounds with a range of x, y, and z values. The thallium L-III-edge x-ray absorption spectra are independent of x, y, and z and are well reproduced by full multiple scattering calculations with a cluster with a radius of 8.5 Angstrom centered on thallium. The iron-57 Mossbauer spectra consist of two doublets and the major component is assigned to iron on the cobalt sublattice in view of its hyperfine parameters. The origin of the minor component is uncertain and is tentatively assigned to either iron with thallium vacancies as next nearest neighbors or to iron in the voids. The tin-119 Mossbauer spectral hyperfine parameters clearly indicate that tin substitutes for antimony in the skutterudite structure. Further, the tin electronic configuration is very similar to that of antimony and is insensitive to the thallium content. (C) 2002 American Institute of Physics. [less ▲]

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See detailCompte rendu de V. de Coorebyter, Sartre face à la phénoménologie
Cormann, Grégory ULg

in Revue Philosophique de Louvain (2002), 1-2

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See detailPrésentation. Du fantastique réel au réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 7-9

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See detailComprendre et prévenir la violence à l'école : vers un référentiel critique des mesures actuelles de prévention et de lutte contre la violence scolaire
Munten, Jacqueline; Jardon, Dorothée; Mouvet, Bernadette ULg

in Point sur la Recherche en Education (Le) (2002), 22

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See detailImage du mois. Une tumeur préauriculaire.
Tassoudji, Nazli ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(2), 65-66

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See detailImage analysis characterization of highly oriented freeze-drying porous materials
Blacher, Silvia ULg; Maquet, Véronique; Jérôme, Robert ULg et al

in Image Analysis and Stereology (2002), 21

Image analysis has been used as a potential tool for the characterization of the texture of ultramacroporous foams prepared by freeze-drying. It has been shown that this technique actually provides ... [more ▼]

Image analysis has been used as a potential tool for the characterization of the texture of ultramacroporous foams prepared by freeze-drying. It has been shown that this technique actually provides valuable information on the structure of this kind of material. Image analysis of SEM micrographs of transverse sections at two different magnifications gave information on both the macroporosity (10 μm < width < 100 μm) and ultramacroporosity (width > 100 μm). Moreover, the foam anisotropy has been determined by image analysis of longitudinal sections. [less ▲]

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See detailUne dorsalgie malheureusement tenace
Malaise, Michel ULg; Kaye, Olivier; Radermecker, Maurice ULg et al

in Revue Médicale de Liège (2002), 57(5), 270-273

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of ... [more ▼]

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of imagery, a meticulous clinical history and physical examination remain mandatory. They will lead the exploration. Idiopathic intercostal neuralgia does not exist. [less ▲]

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See detailNew in situ generated ruthenium catalysts bearing N-heterocyclic carbene ligands for the ring-opening metathesis polymerization of cyclooctene
Delaude, Lionel ULg; Szypa, Magdalena; Demonceau, Albert ULg et al

in Advanced Synthesis & Catalysis (2002), 344(6-7), 749-756

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene ... [more ▼]

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene)](2) and potassium tert-butoxide or sodium hydride to generate the corresponding ruthenium-N-heterocyclic carbene complexes in situ. Catalyst precursors derived from imidazol(in)ium salts bearing the 2,4,6-trimethylphenyl (mesityl) and the 2,6-diisopropylphenyl groups were also prepared. The catalytic activity of all these species in the photoinduced ring-opening metathesis polymerization of cyclooctene was investigated. The C4-C5 double bond in the imidazole ring of the N-heterocyclic carbene ligands was not crucial to achieve high catalytic efficiencies. The presence or the absence of alkyl groups on the ortho positions of the phenyl rings had a more pronounced influence. Blocking all the ortho positions was a requisite for obtaining efficient catalysts. Failure to do so probably results in the ortho-metallation of the carbene ligand, thereby altering the coordination sphere of the ruthenium active centers. [less ▲]

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See detailThe gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man
Marion, Evelyne; Kaisaki, Pamela Jane; Pouillon, Valérie et al

in Diabetes (2002), 51

Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and ... [more ▼]

Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report the presence of SHIP2 gene mutations associated with type 2 diabetes in rats and humans. The R1142C mutation specifically identified in Goto-Kakizaki (GK) and spontaneously hypertensive rat strains disrupts a potential class II ligand for Src homology (SH)-3 domain and slightly impairs insulin signaling in cell culture. In humans, a deletion identified in the SHIP2 3' untranslated region (UTR) of type 2 diabetic subjects includes a motif implicated in the control of protein synthesis. In cell culture, the deletion results in reporter messenger RNA and protein overexpression. Finally, genotyping of a cohort of type 2 diabetic and control subjects showed a significant association between the deletion and type 2 diabetes. Altogether, our results show that mutations in the SHIP2 gene contribute to the genetic susceptibility to type 2 diabetes in rats and humans [less ▲]

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See detailModeling [F-18]MPPF positron emission tomography kinetics for the determination of 5-hydroxytryptamine(1A) receptor concentration with multiinjection
Costes, Nicolas; Merlet, I.; Zimmer, L. et al

in Journal of Cerebral Blood Flow & Metabolism (2002), 22

The selectivity of [F-18]MPPF (fluorine-18-labeled 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pirydynyl)-p-fluorobenzamido]ethylpiperazine) for serotonergic 5-hydroxytryptamine(1A) (5-HT1A) receptors has been ... [more ▼]

The selectivity of [F-18]MPPF (fluorine-18-labeled 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pirydynyl)-p-fluorobenzamido]ethylpiperazine) for serotonergic 5-hydroxytryptamine(1A) (5-HT1A) receptors has been established in animals and humans. The authors quantified the parameters of ligand-receptor exchanges using a double-injection protocol. After injection of a tracer and a coinjection dose of [F-18]MPPF, dynamic positron emission tomography (PET) data Were acquired during a 160-minute session in five healthy males. These PET and magnetic resonance imaging data were coregistered for anatomical identification. A three-compartment model was used to determine six parameters: F-v (vascular fraction). K-1, k(2) (plasma/free compartment exchange rate). k(off). k(on)/V-r (association and dissociation rate), B-max (receptor concentration), and to deduce K-d (apparent equilibrium dissociation rate). The model was fitted with regional PET kinetics and arterial input function corrected for metabolites. Analytical distribution volume and binding potential Were compared With indices generated by Logan-Patlak graphical analysis. The 5HT(1A) specificity for MPPF was evidenced. A B-max of 2.9 pmol/mL and a K-d of 2.8 nmol/L were found in hippocampal regions, K-d and distribution volume in the free compartment were regionally stable. and the Logan binding potential was linearly correlated to B-max. This study confirms the value of MPPF in the investigation of normal and pathologic systems involving the limbic network and 5-HT1A receptors. Standard values can be used for the simulation of simplified protocols. [less ▲]

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See detailUnusual traits of the pyoverdin-mediated iron acquisition system in Pseudomonas putida strain BTP1.
Ongena, MARC ULg; Jacques, Philippe ULg; Delfosse, Philippe et al

in Biometals (2002), 15(1), 1-13

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin ... [more ▼]

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin, Pseudomonas putida strain BTP1 could represent a valuable tool in an attempt to correlate the structural features of these compounds with some specificity in their two main properties i.e. affinity for iron and recognition rate by other Pseudomonas strains. An uncommonly high affinity for iron of the pyoverdin synthetized by P. putida BTP1 was observed by comparing both the apparent stability constant and the decomplexation kinetic of its ferric complex with those of ferripyoverdins from other strains. On another hand, results from growth stimulation experiments and labeled ferripyoverdin uptake assays highlighted the very low recognition rate of BTP1 isopyoverdins by membrane receptors of foreign strains. By contrast, P. putida BTP1 was able to utilize a broad spectrum of structurally unrelated exogenous pyoverdins by means of multiple receptors that are likely constitutively expressed in its outer membrane. The unusual traits of its pyoverdin-mediated iron acquisition system should contribute to enlarge the ecological competence of Pseudomonas putida BTP1 in terms of colonization and persistence in the rhizosphere. [less ▲]

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See detailResponses and adaptations of Episyrphus balteatus and Adalia bipunctata to allelochemicals from Brassicaceae plant through their preys
Vanhaelen, Nicolas; Haubruge, Eric ULg; Gaspar, Charles et al

in International Symposium on Ecology of Aphidophaga (2002)

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See detailHow to substantiate eradication of bovine brucellosis when aspecific serological reactions occur in the course of brucellosis testing.
Godfroid, Jacques; Saegerman, Claude ULg; Wellemans, Vincent et al

in Veterinary Microbiology (2002), 90(1-4), 461-77

Collaborative work was financed by the EU to develop and assess new diagnostic tools that can differentiate between bovine brucellosis and bovine infections due to Yersinia enterocolitica O:9 either in ... [more ▼]

Collaborative work was financed by the EU to develop and assess new diagnostic tools that can differentiate between bovine brucellosis and bovine infections due to Yersinia enterocolitica O:9 either in conjunction with, or as an alternative to, the classical serological, bacteriological or allergic skin tests. Sixteen heifers were experimentally infected with Brucella abortus biovar 1 (five heifers), Brucella suis biovar 2 (two heifers), Y. enterocolitica O:9 (six heifers) and Y. enterocolitica O:3 (three heifers). Four heifers, naturally infected with Y. enterocolitica O:9 that presented aspecific brucellosis serological reactions were also included in the experiment. A self-limited infection was induced in cattle by B. suis biovar 2. All the brucellosis serological tests used, i.e. the slow agglutination test (SAW), the Rose Bengal test (RB), the complement fixation test (CFT), indirect and competitive ELISA's, lacked specificity when used to analyze sera from Y. enterocolitica O:9 infected animals. A Yersinia outer membrane proteins (YOPs)-ELISA was also used and although the test is able to detect a Yersinia group infection, it provided no evidence of whether or not there is a possible brucellosis infection when dual infections are present. The brucellergen IFN-gamma test showed a lack of specificity also. The only test that was proven to be specific is the brucellergen skin test. All brucellosis serological tests, except the indirect ELISA, were limited in their ability to detect B. abortus persistently infected animals. Based on these experimental studies, a strategy was implemented as part of the year 2001 Belgian Brucellosis Eradication Program to substantiate the eradication of bovine brucellosis. Epidemiological inquiries have identified risk factors associated with aspecific serological reactions, possible transmission and infection of cattle by B. suis biovar 2 from infected wild boars; and both legal and administrative measures taken by the veterinary services. No cases of bovine brucellosis have been confirmed in Belgium since March 2000. [less ▲]

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See detailCurrent treatments of muco-cutaneous herpes simplex virus infections
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Current Medicinal Chemistry - Anti-Infective Agents (2002), 1(1), 83-98

Infection by Herpes Simplex Virus (HSV) types I and II represent a worldwide medical problem. After the primary infection the virus establishes a life-long latency in the dorsal root ganglia and ... [more ▼]

Infection by Herpes Simplex Virus (HSV) types I and II represent a worldwide medical problem. After the primary infection the virus establishes a life-long latency in the dorsal root ganglia and recurrences may occur at unpredictable times and rate. The most frequent clinical presentation of HSV infection is recurrent herpes labialis and herpes genitalis. The clinical expression varies according to the body site, the infected cell type, the relationship between HSV and the host immune status. Viral identification techniques such as immunohistochemistry and in situ hybridization on Tzanck smears and muco-cutanenous biopsies are helpful in the diagnosis of atypical cutaneous lesions. The treatment modalities of HSV infections include the reduction of viral load using antiviral agents, the non-specific immune stimulation of the host and specific vaccination in order to prevent new acquisition and to mitigate symptoms in already infected individuals. This review addresses various therapeutic options, their mode of action, and clinical value as well as the indications of the various drugs. [less ▲]

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See detailInfo-congres. Essai de prevention du diabete de type 1 par le nicotinamide: les lecons positives d'un essai clinique negatif (ENDIT).
Philips, Jean-Christophe ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(10), 672-5

ENDIT ("European Nicotinamide Diabetes Intervention Trial") is a large placebo-controlled randomised clinical trial that aimed at studying the efficacy of nicotinamide in the prevention of type 1 diabetes ... [more ▼]

ENDIT ("European Nicotinamide Diabetes Intervention Trial") is a large placebo-controlled randomised clinical trial that aimed at studying the efficacy of nicotinamide in the prevention of type 1 diabetes mellitus among first-degree relatives of type 1 diabetic patients with positive islet cell antibodies (ICA). The results presented at the last congress of the European Association for the Study of Diabetes (EASD) in Budapest do not evidence any significant difference in the risk of developing overt diabetes mellitus in the patients treated with nicotinamide (n = 274) as compared to those receiving placebo (n = 275) after 5 years of follow-up. Despite these negative results, positive lessons could be drawn from ENDIT: 1) the feasibility of a large long-standing multicentre European trial in a difficult research area; 2) the importance of large randomised controlled clinical trials to bring the evidence requested by "Evidence-Based Medicine"; 3) the predictive value of various risk markers to progress toward type 1 diabetes in first-degree relatives, especially the number of positive auto-antibodies; and 4) the urgent need to continue intensive research in this important field of preventive medicine. [less ▲]

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See detailLe roman poétique en 1929. Nord, entre fantastique réel et réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 31-40

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See detailHamstring muscle strain recurrence and strength performance disorders
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Namurois, Marie-Hélène ULg et al

in American Journal of Sports Medicine (2002), 30(2, Mar-Apr), 199-203

We determined the frequency of strength disorders in 26 athletes with a history of hamstring muscle injury and recurrent strains and discomfort. We also assessed the effectiveness of rehabilitation to ... [more ▼]

We determined the frequency of strength disorders in 26 athletes with a history of hamstring muscle injury and recurrent strains and discomfort. We also assessed the effectiveness of rehabilitation to correct muscle performance. After concentric and eccentric isokinetic assessment, 18 athletes were found to have strength deficits, as determined by statistically selected cutoffs of peak torque, bilateral differences, and the flexors/quadriceps ratio. The discriminating character of the eccentric trial was demonstrated, combining a preferential eccentric peak torque deficit and a significant reduction of the mixed eccentric flexors/concentric quadriceps ratio. The athletes with muscle imbalances followed a rehabilitation program individually adapted from their strength profile. Treatment length was from 10 to 30 sessions and resulted in isokinetic parameter normalization in 17 of 18 subjects. Isokinetically corrected subjects were observed for 12 months after return to athletics. None sustained a clinically diagnosed hamstring muscle reinjury. Subjective intensity of pain and discomfort were significantly reduced, and they all returned to their prior level of competition. These results demonstrate that persistent muscle strength abnormalities may give rise to recurrent hamstring injuries and discomfort. An individualized rehabilitation program emphasizing eccentric training based on specific deficits contributes to a decrease in symptoms on return to sports. [less ▲]

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See detailAspects de la conclusion du contrat par voie électronique
Biquet, Christine ULg; Decharneux, Joëlle ULg

in Actualités du Droit (2002)

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See detailComposition de la carcasse, qualité de viande et exploitation du Piétrain stress négatif
Youssao, A. K. L.; Verleyen, Vincent ULg; Michaux, Charles ULg et al

in Annales de Médecine Vétérinaire (2002), 146(6), 329-338

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See detailLa réforme de l'adoption pas à pas. Note sous C.A., 28 novembre 2001
Leleu, Yves-Henri ULg

in Journal des Tribunaux (2002)

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See detailCombined implicit-explicit algorithms for non-linear structural dynamics
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Revue Européenne des Éléments Finis (2002), 11(5), 565-591

To solve fast dynamic problems, an explicit method is the most adapted. But for slower dynamics, an implicit method is more stable. The industrial problems are governed by high frequency (impact ... [more ▼]

To solve fast dynamic problems, an explicit method is the most adapted. But for slower dynamics, an implicit method is more stable. The industrial problems are governed by high frequency (impact, ...) during short time intervals and slower dynamics (spring-back, ...) during other time intervals. The optimal solution is then to have both implicit algorithm and explicit methods readily available in the same code and to be able to switch automatically from one to another. Criteria that decide when to shift from a method to another have been developed here. Implicit balanced restarting conditions that annihilate numerical oscillations resulting for an explicit calculation are also proposed. [less ▲]

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See detailMulticollinearity in prognostic factor analyses using the EORTC QLQ-C30: identification and impact on model selection
Van Steen, Kristel ULg; Curran, D.; Kramer, J. et al

in Statistics in Medicine (2002), 21(24), 3865-3884

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to ... [more ▼]

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to chemotherapy. For response, different final multivariate models were obtained from forward and backward selection methods, suggesting a disconcerting instability. Quality of life was measured using the EORTC QLQ-C30 questionnaire completed by patients. Subscales on the questionnaire are known to be highly correlated, and therefore it was hypothesized that multicollinearity contributed to model instability. A correlation matrix indicated that global QL was highly correlated with 7 out of 11 variables. In a first attempt to explore multicollinearity, we used global QL as dependent variable in a regression model with other QL subscales as predictors. Afterwards, standard diagnostic tests for multicollinearity were performed. An exploratory principal components analysis and factor analysis of the QL subscales identified at most three important components and indicated that inclusion of global QL made minimal difference to the loadings on each component. suggesting that it is redundant in the model, In a second approach, we advocate a bootstrap technique to assess the stability of the models. Based on these analyses and since global QL exacerbates problems of multicollinearity, we therefore recommend that global QL be excluded from prognostic factor analyses using the QLQ-C30. The prognostic factor analysis was rerun without global QL in the model, and selected the same significant prognostic factors as before. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailAmélioration des ovins dans l'Ouémé et le Plateau en République du Bénin. Enjeux des croisements des ovins Djallonké avec les moutons du Sahel
Gbangboche, A. B.; Abiola, F. A.; Laporte, J.-P. et al

in Tropicultura (2002), 20(2), 70-75

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See detailPISA : une enquête en suspicion légitime
Dumortier, Jean-Louis ULg

in Lettre de la DFLM (2002), 30

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See detailL'organisation au regard de l'esthétique
Servais, Christine ULg; Heller, Thomas

in Recherches en Communication (2002), 17

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See detailInteraction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane.
Aguedo, Mario ULg; Beney, Laurent; Wache, Yves et al

in International journal of food microbiology (2002), 80(3), 211-5

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological ... [more ▼]

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. Gamma-decalactone was previously shown to have antimicrobial properties. We determined by infrared spectroscopy measurements that this compound rapidly diffused into model phospholipid bilayers (within 2 min), modifying the general physical state of a dimyristoyl-L-alpha-phosphatidylcholine (DMPC) film. In vivo, the lactone strongly increased membrane fluidity in the model yeast Yarrowia lipolytica, as evaluated by fluorescence anisotropy measurements. This effect was more important than that of benzyl alcohol, which is known as a fluidizing agent in living cells, and may explain the toxic action of gamma-decalactone in microorganisms. [less ▲]

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See detailL'etude clinique du mois. L'etude LIPS: prevention par la fluvastatine des accidents cardiaques apres angioplastie coronaire percutanee.
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(7), 479-82

The prospective placebo-controlled LIPS study ("Lescol Intervention Prevention Study") demonstrated a significant cardiovascular protection by fluvastatin in patients with coronary artery disease (stable ... [more ▼]

The prospective placebo-controlled LIPS study ("Lescol Intervention Prevention Study") demonstrated a significant cardiovascular protection by fluvastatin in patients with coronary artery disease (stable or unstable angina, silent ischemia), without major hypercholesterolaemia (135-270 mg/dl) following successful completion of their first percutaneous coronary intervention. When compared to the placebo group (n = 833), the fluvastatin group (n = 844) showed a relative risk reduction by 22% (relative risk: 0.78; 95% confidence interval: 0.64-0.95; p = 0.01) of major adverse cardiac events after a median time of follow-up of 3.9 years. This effect is observed independently of baseline total cholesterol, of the presence of diabetes mellitus or the existence of multivessel disease. These results suggest that fluvastatin may favorably influence the restenosis process after percutaneous coronary intervention, even in the absence of severe hypercholesterolaemia. [less ▲]

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See detailPour une sémiologie historique de l'acte photographique
Havelange, Carl ULg

in Revue de la Faculté des Lettres d'El Jadida (2002)

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See detailRegelgeving inzake het zelfbeschikkingsrecht, Redactie Privaat
Leleu, Yves-Henri ULg

in Tijdschrift voor Privaatrecht (2002)

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See detailDéminéralisation et ostéoporose: une confusion sémantique
Kaiser, Marie-Joëlle ULg; Malaise, Michel ULg

in Revue Médicale de Liège (2002), 57(5), 274-279

Osteoporosis is the most frequent demineralizing disease. However, when a demineralized vertebra is identified, other diseases must be ruled out in the course of diagnosis. Through three clinical cases ... [more ▼]

Osteoporosis is the most frequent demineralizing disease. However, when a demineralized vertebra is identified, other diseases must be ruled out in the course of diagnosis. Through three clinical cases, we analyze pitfalls that have delayed the diagnosis of one rare, but unfortunately lethal, aetiology: multiple myeloma. [less ▲]

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See detailLes troubles morpho-syntaxiques développementaux en langage oral : quel cadre théorique adopter?
Maillart, Christelle ULg; Schelstraete, Marie-Anne; Hupet, Michel

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2002), 37(2), 85-102

This article contrasts two theoretical frames actually used to account for morphosyntactic disorders in children with specific language impairment. The first one stems from a traditional formal linguistic ... [more ▼]

This article contrasts two theoretical frames actually used to account for morphosyntactic disorders in children with specific language impairment. The first one stems from a traditional formal linguistic account developped in the context of Chomsky’s works while the second approach, the emergent account, is more functional. Following the linguistic account, it has been assumed that children are born with an innate set of representational constraints, the Universal Grammar, on which grammars are possible for a given language. In contrast, for the emergentist view, it is not necessary to postulate an autonomous device that evolved for grammar rather language in general, and grammar in particular, would emerge from cognitive and communicative abilities and linguistic environment. Both theoretical frames are briefly presented and discussed as well as their implications for the pathology study in children. [less ▲]

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See detailLa reconnaissance et le financement de la laïcité (II)
Husson, Jean-François ULg; Sägesser, Caroline

in Courrier Hebdomadaire du CRISP (2002), (1760), 3-52

This paper details the administrative organisation and financial support for the various organisations and services from the Belgian free thinkers, after an official recognition on a footing quite similar ... [more ▼]

This paper details the administrative organisation and financial support for the various organisations and services from the Belgian free thinkers, after an official recognition on a footing quite similar to the one of religious denominations. [less ▲]

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See detailLe détecteur de mensonges à la rescousse de la défense ?
Monville, Pierre ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

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See detailStreamlining cosmetology by standardized testing?
Pierard, Gérald ULg

in Journal of Cosmetic Dermatology (2002), 1(2), 97-898

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See detailThe Otherness of Self. A Genealogy of the Self in Contemporary China
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (2002), Volume XIV

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See detailExercise-induced pulmonary perfusion redistribution in heaves
Harmegnies, N. F.; Duvivier, D. H.; Vandenput, Sandrina ULg et al

in Equine Veterinary Journal. Supplement (2002), 34(suppl), 478-484

This study aimed to compare exercise-induced pulmonary perfusion redistribution in healthy vs. 'heavey' horses using scintigraphy, a minimally invasive technique. Six healthy (A) and 5 'heavey' horses in ... [more ▼]

This study aimed to compare exercise-induced pulmonary perfusion redistribution in healthy vs. 'heavey' horses using scintigraphy, a minimally invasive technique. Six healthy (A) and 5 'heavey' horses in remission (B(I)) and during clinical signs of disease (B(II)) were investigated. Dimensions of the exercising pulmonary perfusion (QE) images were expressed in percent of the resting perfusion (QR) images. Computed QE to QR ratios (QE/QR) images enabled the definition of the region more perfused at exercise than at rest (R1). In all groups, exercise induced a major enlargement of the Q image but a larger increase of the lung height was found in 'heavey' horses. Compared to A, 'heavey' horses showed a larger R1 region with a significantly higher QE/QR. Location of R1 pointed out the dorsal lung region as a major site of pulmonary perfusion redistribution for all groups. This work demonstrated (1) the feasibility of using scintigraphy for studying exercise-induced pulmonary perfusion redistribution; (2) perfusion redistribution to the dorsal lung with exercise and (3) an intensified redistribution in 'heavey' horses, either clinically affected or not. [less ▲]

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See detailL'égalité et le droit commercial: un rapport à géométrie variable
Thirion, Nicolas ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

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See detailPoesia dell’alto medioevo europeo : manoscritti, lingua e musica dei ritmi latini
Moreno, Paola ULg

in Scriptorium (2002), 267

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See detailA. Gacek: The Arabic manuscript tradition: A glossary of technical terms and bibliography
Bauden, Frédéric ULg

in Journal of the American Oriental Society (2002), 122(3), 658-659

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See detailDe la débrouillardise à la recherche active... Réflexions sur une expérience pédagogique.
Guillaume, Jean-François ULg; Xhonneux, Michel ULg

in L'Ecole Valdôtaine. Cahier pédagogique (2002), 57

Présentation d'un dispositif d'apprentissage axé sur la résolution de situations-problèmes visant à confronter des jeunes parvenus en fin de scolarité obligatoire aux institutions, aux organismes et/ou ... [more ▼]

Présentation d'un dispositif d'apprentissage axé sur la résolution de situations-problèmes visant à confronter des jeunes parvenus en fin de scolarité obligatoire aux institutions, aux organismes et/ou aux services actifs dans le domaine de la protection sociale et de l'aide sociale. [less ▲]

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See detailInsecticide activity of surfactins and iturins from a biopesticide Bacillus subtilis Cohn (S499 strain)
Assié, Lazar; Deleu, Magali ULg; Arnaud, Ludovic et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2002), 67(3), 647-655

Surfactin C14, surfactin C15, and iturin C15 are lipopeptides purified from Bacillus subtilis (S499 strain). They were incorporated into the artificial diet of the fruit fly Drosophila melanogaster to ... [more ▼]

Surfactin C14, surfactin C15, and iturin C15 are lipopeptides purified from Bacillus subtilis (S499 strain). They were incorporated into the artificial diet of the fruit fly Drosophila melanogaster to assess their potential insecticidal activities. Surfactins with long fatty acid chains (C14 and C15) had an insecticidal effect on the fruit fly, D. melanogaster. On the contrary, iturin was not toxic to D. melanogaster. At 100 ppm, surfactin C14 and C15 caused 85.4 and 92.6% adult mortality, respectively, after a one-day exposure. F1 progeny fly emergence inhibition by C14 and C15 were 79.8 and 91.3%, respectively. To check whether the biocide activity of lipopeptides was due to their surface-active properties, detergent Triton X100, SDS, CTAB, and Tween 80 were tested. No adult mortality was recorded with the detergents but Triton X100 and SDS showed F1 progeny emergence inhibition similar to that of surfactins. We showed that there was a dose-response activity with surfactin C15 [less ▲]

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See detailLe GPS et la Physique
Garnir, Henri-Pierre ULg; Strivay, David ULg; Bastin, Thierry ULg

in Science and Culture (2002), 380

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See detailBeroepsgeheim, confidentialiteit en de bedrijfsjurist: de nieuwe situatie
Thirion, Nicolas ULg; Benoit-Moury, Anne

in Tijdschrift voor Rechtspersoon en Vennootschap (2002), 1

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See detailSplit face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.
Uhoda, Isabelle; Faska, Najat; Robert, Caroline et al

in Skin Research & Technology (2002), 8(3), 164-7

BACKGROUND/AIMS: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel ... [more ▼]

BACKGROUND/AIMS: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. METHODS: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. RESULTS: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. CONCLUSION: The DMAE formulation under investigation increased skin firmness. [less ▲]

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See detailSternal recumbency or suspension by the hind legs immediately after delivery improves respiratory and metabolic adaptation to extra uterine life in newborn calves delivered by caesarean section.
Uystepruyst, Christophe; Coghe, Joost; Dorts, Thierry et al

in Veterinary Research (2002), 33(6), 709-724

The aim of this study was to evaluate the effect of body positioning immediately after delivery on respiratory and metabolic adaptation to extra-uterine life in newborn calves. One hundred and one Belgian ... [more ▼]

The aim of this study was to evaluate the effect of body positioning immediately after delivery on respiratory and metabolic adaptation to extra-uterine life in newborn calves. One hundred and one Belgian White and Blue calves were delivered at term by an elective caesarean section and were assigned into three categories according to the body position imposed immediately after umbilical cord rupture: 71 calves were placed in lateral recumbency; 16 calves were placed in sternal recumbency and 14 calves were suspended by the hind legs for less than 90 seconds (75 +/- 5 s). Following this initial body position, the calves were allowed to move without restraint. They were examined at birth, 5, 15, 30, 45 and 60 minutes, and 2, 3, 6, 12 and 24 hours after birth by the following measurements: physical examination, heart rate, arterial blood gas analysis, pulmonary function tests using the esophageal balloon catheter technique, arterial and venous blood acid-base balance analysis, rectal temperature, jugular venous blood sampling for the determination of blood glucose, plasma lactate and serum cortisol concentrations, haematologic variables and passive immune transfer variables. Body positioning immediately after delivery clearly influenced respiratory and metabolic adaptation to extra-uterine life in term calves delivered by an elective caesarean section. Systematic sternal recumbency and suspension by the hind legs for less than 90 seconds immediately after umbilical cord rupture had a positive functional impact on postnatal pulmonary mechanics and gas exchange and on postnatal correction of mixed acidosis present at birth, contributing in turn to an enhanced passive immune transfer. These two body positions should be encouraged to improve adaptation at birth in healthy term calves delivered by an elective caesarean section. Evaluation of possible side-effects is required before application in severely asphyxiated calves. [less ▲]

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See detailEtalonnage de la figure complexe de Rey sur une population d’enfants de six à douze ans
Garcet, Serge ULg; Deltour, Jean-Jacques; Remacle, Michel

in Revue Scientifique de l'AIGS (2002), 1

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See detailUne allergie conjugale exacerbée: les dermatoses par procuration.
Martalo, O.; Fraiture, A. L.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(5), 320-3

A young woman presented two distinct vesiculobullous dermatoses sharing in common her husband's imputability. She suffered from contact dermatitis due to colophony used by her husband who was violinist ... [more ▼]

A young woman presented two distinct vesiculobullous dermatoses sharing in common her husband's imputability. She suffered from contact dermatitis due to colophony used by her husband who was violinist. During her second pregnancy, pemphigoid gestationis was diagnosed. This autoimmune disease is directed to the father's HLA class II present on the placenta. The same antibodies also interact with the dermo-epidermal junction in the mother where they induce blisters. [less ▲]

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See detailAortofemorographie par resonance magnetique nucleaire versus arteriographie conventionnelle: evaluation prospective.
NCHIMI LONGANG, Alain ULg; Brisbois, D.; Donkers, E. et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2002), 85(5), 246-51

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively ... [more ▼]

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively compared to DSA in 49 consecutive patients (40 males, 9 females; age range 38-80 years; mean age 64 years). According to Leriche and Fontaine's clinical gradation of lower limb ischemia, 5 patients were graded I, 37 graded II, 4 graded III, and 3 graded IV. Two observers graded stenoses for DSA and three for MRA. Cohen's kappa statistics were used to evaluate interobserver variability using MRA, as well as to compare MRA to DSA. In addition, sensitivity, specificity, positive and negative predictive values of MRA for the assessment of stenosis superior to 80% were calculated by using DSA as a gold standard, respectively for arterial trunks above and below the level of the knees. RESULTS: Overall accuracy of MRA was 92%. Comparison of DSA and MRA yielded a kappa value of 0.87 (0.95 for arterial trunks located above the level of the knees and 0.75 below). Interobserver agreement was very good. Sensitivity, specificity, positive and negative predictive values of MRA for the diagnosis of > 80% stenosis were respectively 98, 98, 85 and 99% above the level of the knees and 87, 91, 77 and 96% below the knees. CONCLUSION: MRA can be considered as valuable technique for the evaluation of peripheral arterial obstructive disease, especially for stenosis located above the level of the knees. [less ▲]

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See detailInhibition Of Histone Deacetylases Induces Bovine Leukemia Virus Expression In Vitro And In Vivo
Merezak, C.; Reichert, M.; Van Lint, C. et al

in Journal of Virology (2002), 76(10),

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See detailPrognosis of hematologic malignancies does not predict intensive care unit mortality.
MASSION, Paul ULg; Dive, Alain M; Doyen, Chantal et al

in Critical Care Medicine (2002), 30(10), 2260-70

OBJECTIVE: To evaluate the correlation between specific prognosis of hematologic malignancies on the one hand and intensive care unit and hospital mortality in critically ill patients with hematologic ... [more ▼]

OBJECTIVE: To evaluate the correlation between specific prognosis of hematologic malignancies on the one hand and intensive care unit and hospital mortality in critically ill patients with hematologic malignancies on the other hand. DESIGN: Observational study during a 10-yr period. SETTING: A 22-bed medical-surgical intensive care unit. PATIENTS: A total of 84 consecutive patients with nonterminal hematologic malignancies with medical complications requiring intensive care. INTERVENTIONS: None. MEASUREMENTS: Demographic factors, acute physiology and organ dysfunction scores, microbiology, therapeutic support, and hematologic factors data on admission and during the intensive care unit stay were collected, together with mortality follow-up. Based on specific-disease prognostic factors and related published survival curves, the prognosis of hematologic malignancies was assessed and defined as good, intermediate, or poor according to a 3-yr survival probability of >50%, 20-50%, or <20%, respectively. MAIN RESULTS: Prognosis of hematologic malignancies does not predict intensive care unit or hospital mortality and almost reaches significance for 6-mo mortality (53%, 71%, and 84% rate for patients with good, intermediate, and poor prognosis, respectively, p =.058), but it determines long-term survival (p =.008). Intensive care unit, hospital, and 6-mo overall mortality rates were 38%, 61%, and 75%, respectively. Using multivariate analysis, intensive care unit mortality was best predicted on admission by respiratory failure and fungal infection, whereas hospital mortality was predicted by the number of organ failures, the bone marrow transplant status, and the presence of fungal infection. The Acute Physiology and Chronic Health Evaluation II and the Simplified Acute Physiology Score II had no prognostic value, whereas the difference of the Multiple Organ Dysfunction Score between at the time of admission and at day 5 allowed quick prediction of hospital mortality. Diseases with the poorest 6-mo prognosis were acute myeloid leukemia and non-Hodgkin lymphoma. CONCLUSION The severity of the underlying hematologic malignancies does not influence intensive care unit or hospital mortality. Short-term prognosis is exclusively predicted by acute organ dysfunctions and by a pathogen's aggressiveness. Therefore, reluctance to admit patients with nonterminal hematologic malignancies to the intensive care unit based only on the prognosis of their underlying hematologic malignancy does not seem justified. [less ▲]

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See detailInstrumental non-invasive assessments of cosmetic efficacy.
Pierard, Gérald ULg

in Journal of Cosmetic Dermatology (2002), 1(2), 57-8

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See detailEnergy Partitioning Between Latent And Sensible Heat Flux During The Warm Season At Fluxnet Sites
Wilson, Kell B.; Baldocchi, Dennis D.; Aubinet, Marc ULg et al

in Water Resources Research (2002), 38(12),

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See detailDHEA et intracrinologie de jouvence pour la peau? Entre raison et magie.
Bourguignon, Raphael; Uhoda, I.; Henry, Frédérique ULg et al

in Revue Médicale de Liège (2002), 57(7), 438-42

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In ... [more ▼]

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In the skin, sebaceous glands enlarge and seborrhoea increases in post-menopausal women. No other effect is clinically discernable on the skin. At this level, DHEA does not show efficacy comparable to that of other anti-ageing compounds. [less ▲]

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See detailModellierung von Faserbett-Koaleszenzabscheidern
Speth, H; Pfennig, Andreas ULg; Chatterjee, M et al

in Chemie Ingenieur Technik (2002), 74(3), 266-270

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