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See detailL'associatif au carrefour des économies formelle et informelle
Defourny, Jacques ULg

in Recherches Sociologiques et Anthropologiques (1994), (1994/3), 109-127

Depuis toujours, la vie associative s’est exprimée à la fois dans des formes officiellement admises par les gouvernants et dans des cadres informels, souvent même clandestins. La reconnaissance du statut ... [more ▼]

Depuis toujours, la vie associative s’est exprimée à la fois dans des formes officiellement admises par les gouvernants et dans des cadres informels, souvent même clandestins. La reconnaissance du statut juridique d’association sans but lucratif (A.S.B.L.) en 1921 a ouvert la voie à un développement considérable des structures associatives en Belgique, mais une part substantielle du phénomème associatif continue à se manifester en dehors de ce statut. Quant au bénévolat, très important dans de nombreuses associations, il renforce encore l’ancrage de l’associatif dans l’économie informelle. La coexistence de dimensions formelles et informelles ainsi que la pauvreté des statistiques officielles expliquent pour une bonne part le peu d’intérêt des économistes pour les associations. Ces dernières années cependant, l’analyse économique des associations a progressé et quelques enquêtes sont venues compléter les élémentaires recensements officiels. L’inventaire des données actuellement disponibles en Belgique montre toutefois l’ampleur du chemin qui reste à parcourir. [less ▲]

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See detailL'invasion cancéreuse mammaire: le rôle clé des cellules normales des tissus hôtes
Foidart, Jean-Michel ULg; Polette, M.; Birembaut, P. et al

in Bulletin de l'Académie Nationale de Médecine (1994), 178(3), 533-42542-4

Tumor progression is influenced by extracellular matrices and by soluble factors or cytokines locally produced by host tissue cells (fibroblasts, immune cells ...). Such factors may also accumulate in ... [more ▼]

Tumor progression is influenced by extracellular matrices and by soluble factors or cytokines locally produced by host tissue cells (fibroblasts, immune cells ...). Such factors may also accumulate in close association with some extracellular matrix molecules in the tumor. They may also be unmasked during breaking down of extracellular matrices. The most insidious aspect of tumors is their propensity to locally invade normal tissues of the host and to form secondary foci in organs at distant sites from the primary tumor called metastases. During this process, invasive cells come into contact with host tissue cells such as fibroblasts, endothelial cells, macrophages, lymphocytes. These cells are not the passive witnesses of the metastatic cascade but actively participate to the malignant invasion. Through soluble messages (cytokines) and through insoluble molecules of the extracellular matrix, neoplastic and normal cells mutually modulate their activities. Cancer cells regulate the biosynthetic activities of fibroblasts and alter in this way the scaffold of the tumor. Reciprocally, host cells secrete extracellular matrix proteins and cytokines which influence the growth and activities of tumor cells. They also produce at the periphery of tumor cells proteolytic enzymes which promote host tissue destruction and cancerous cells migration. Among these enzymes, matrix metalloproteinases appear to play a key role during invasion and metastasis. Tumors represent thus a complex ecosystem. Tumor cells interact with several components of the extracellular matrix and with host cells (immune cells, fibroblasts, endothelial cells). Such multiple cell-cell and cell-matrix interactions condition angiogenesis, tumor growth, destruction of host tissues, local migration of cancer cells and their metastatic dissemination. It is probable that a precise knowledge of the genes which are selectively activated in tumors under the influence of the host cells or of the tumor cells will allow to define new therapeutic strategies. These treatments will aim not at destroying the metastatic neoplastic cells but at preventing their growth by interfering with their microenvironment. [less ▲]

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See detailGonadotropin Releasing Hormone Inhibitory Autofeedback by Subproducts Antagonist at N-Methyl-D-Aspartate Receptors: A Model of Autocrine Regulation of Peptide Secretion
Bourguignon, Jean-Pierre ULg; Alvarez Gonzalez, Maria-Luz ULg; Gerard, Arlette ULg et al

in Endocrinology (1994), 134(3), 1589-92

The secretion of Gonadotropin-releasing Hormone (GnRH) involves activation of N-methyl-D-aspartate (NMDA) receptors. Here, we show that pulsatile GnRH secretion from hypothalamic explants is suppressed by ... [more ▼]

The secretion of Gonadotropin-releasing Hormone (GnRH) involves activation of N-methyl-D-aspartate (NMDA) receptors. Here, we show that pulsatile GnRH secretion from hypothalamic explants is suppressed by 1-5GnRH, an endogenous breakdown product of GnRH, while 2-10GnRH has no effect. GnRH secretion evoked by NMDA is selectively inhibited by 1-5GnRH and this effect is similar to that of AP-5, a competitive antagonist at NMDA receptors. In addition, 1-5GnRH accounts for a dose-related inhibition of tritiated glutamate binding to hypothalamic membrane preparations. Using GnRH secretion as a model of NMDA-receptor controlled system, the effect of different peptides has been studied. Growth Hormone Releasing Factor (GRF), Insulin-like Growth Factor-I (IGF-I) and Proinsulin result in inhibition of GnRH secretion. Bioactive subproducts of those peptides (1-29GRF, 4-701GF-I and insulin) do not show any effect, suggesting that their classical receptors are not involved. In contrast, GnRH secretion is inhibited by other subproducts (1-37GRF, 1-31GF-I and C-peptide) all terminating in a glutamate residue. These subproducts selectively suppress the NMDA-evoked secretion of GnRH. Protease inhibitors prevent the inhibitory effects of IGF-I on GnRH secretion. This, breakdown products of different peptide hormones are possible endogenous antagonists at NMDA receptors. This effect could account for an autocrine or paracrine limitation of NMDA-receptor-mediated secretion of peptides. [less ▲]

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See detailSalt-free polyelectrolyte behavior of polystyrene-based telechelic ionomers in a polar solvent. 1. Viscosity and low-angle light scattering studies
Wu, Jhi-Li; Wang, Yu-Min; Hara, Masanori et al

in Macromolecules (1994), 27(5), 1195-1200

Some characteristic behavior, typically observed for salt-free polyelectrolytes in water, was observed for the first time for polystyrene (PS)-based telechelic ionomers, which have ionic groups located ... [more ▼]

Some characteristic behavior, typically observed for salt-free polyelectrolytes in water, was observed for the first time for polystyrene (PS)-based telechelic ionomers, which have ionic groups located only at the chain ends, when dissolved in a polar solvent, dimethylformamide (DMF). The characteristic behavior observed by both viscosity and low-angle light scattering measurements for the telechelic ionomers, especially that of the monofunctional ionomer, demonstrates an important role of intermolecular electrostatic interactions in causing the characteristic behavior of telechelic ionomers. The behavior observed in our experiments can best be described by the following picture: each ionomer molecule with a coil conformation, very close to that of polystyrene of the same molecular weight, is separated from yet strongly interacts with other ionomer molecules; and these strong intermolecular electrostatic interactions cause a marked upturn in reduced viscosity and a reduction in scattered intensity. [less ▲]

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See detailPyridobenzoxazepine and Pyridobenzothiazepine Derivatives as Potential Central Nervous System Agents: Synthesis and Neurochemical Study
Liégeois, Jean-François ULg; Rogister, F. A.; Bruhwyler, J. et al

in Journal of Medicinal Chemistry (1994), 37(4), 519-25

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N-methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine ... [more ▼]

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N-methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine derivatives were prepared. The affinities for D2, D1, 5-HT2, and cholinergic (M) receptors were measured. In comparison to dibenzazepine reference compounds, a strong decrease of the affinities was observed, less pronounced, however, for the substituted analogues. Oxazepine and thiazepine analogues like clozapine (except 8-chloro-6-(4-methylpiperazin-1-yl)-pyrido[2,3-b][1,4]benzoxazepin e (9) and 8-chloro-6-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,4]- benzothiazepine (11)) were found to be inactive against apomorphine stereotypies. In the open-field test in rats, different molecules showed a high disinhibitory activity as observed with anxiolytic drugs. Moreover, 8-chloro-5-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine (14) presented a clozapine-like profile that was confirmed in the behavioral model in dogs and showed most of the behavioral characteristics described for antipsychotic drugs. Its neurochemical profile, in particular the 5-HT2/D2 ratio, was also compatible with atypical antipsychotic activity. [less ▲]

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See detailEngineering and Overexpression of Periplasmic Forms of the Penicillin-Binding Protein 3 of Escherichia Coli
Fraipont, Claudine ULg; Adam, Maggy; Nguyen-Disteche, Martine et al

in Biochemical Journal (1994), 298(1), 189-195

Replacement of the 36 and 56 N-terminal amino acid residues of the 588-amino-acid-residue membrane-bound penicillin-binding protein 3 (PBP3) of Escherichia coli by the OmpA signal peptide allows export of ... [more ▼]

Replacement of the 36 and 56 N-terminal amino acid residues of the 588-amino-acid-residue membrane-bound penicillin-binding protein 3 (PBP3) of Escherichia coli by the OmpA signal peptide allows export of F37-V577 PBP3 and G57-V577 PBP3 respectively into the periplasm. The modified ftsI genes were placed under the control of the fused lpp promoter and lac promoter/operator; expression of the truncated PBP3s was optimized by varying the copy number of the recombinant plasmids and the amount of LacI repressor, and export was facilitated by increasing the SecB content of the producing strain. The periplasmic PBP3s (yield 8 mg/l of culture) were purified to 70% protein homogeneity. They require the presence of 0.25 M NaCl to remain soluble. Like the membrane-bound PBP3, they undergo processing by elimination of the C-terminal decapeptide I578-S588, they bind penicillin in a 1:1 molar ratio and they catalyse hydrolysis and aminolysis of acyclic thioesters that are analogues of penicillin. The membrane-anchor-free PBP3s have ragged N-termini. The G57-V577 PBP3, however, is less prone to proteolytic degradation than the F37-V577 PBP3. [less ▲]

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See detailFIELD OBSERVATIONS ON A MATING ATTEMPT OF A SPAWNING GRAYLING, THYMALLUS-THYMALLUS WITH A FEEDING BARBEL, BARBUS-BARBUS
Poncin, Pascal ULg

in Journal of Fish Biology (1994), 45(5), 904-906

During the spawning period of the grayling, one male was sexually stimulated by a feeding barbel and consequently exhibited the behavioural pattern of 'approach', 'quivering' and 'dorsal fin clasping'.

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See detailCoordinate Enhancement of Gelatinase a Mrna and Activity Levels in Human Fibroblasts in Response to Breast-Adenocarcinoma Cells
Noël, Agnès ULg; Polette, M.; Lewalle, J. M. et al

in International Journal of Cancer = Journal International du Cancer (1994), 56(3), 331-6

Gelatinases/type-IV collagenases are metalloproteinases involved in some carcinoma invasion and metastatic processes. The exact cellular source of the 72-kDa gelatinase A is controversial. We have ... [more ▼]

Gelatinases/type-IV collagenases are metalloproteinases involved in some carcinoma invasion and metastatic processes. The exact cellular source of the 72-kDa gelatinase A is controversial. We have analyzed the expression of mRNA coding for gelatinase A in vivo by in situ hybridization on breast-cancer tissues. The mRNA for gelatinase A was present in fibroblasts. We have therefore evaluated the gelatinase-A activity in vitro, in co-cultures of different breast adenocarcinoma cell lines and human fibroblasts. In monoculture, none of the tumor cells tested produced detectable amounts of gelatinase A. The gelatinase-A activity was enhanced in cultures of fibroblasts maintained in the presence of MDA-MB 231 or SKBR3 cells, or their conditioned medium. This increased enzymatic activity was evidenced both in the culture medium and in the membrane fraction and was paralleled by enhancement of the steady-state levels of mRNA. These results are an in vitro demonstration of a regulation of fibroblasts gelatinase-A production by soluble factors secreted by breast-tumor cells. [less ▲]

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See detailSelf-Treatment of Acute Migraine with Subcutaneous Sumatriptan Using an Auto-Injector Device: Comparison with Customary Treatment in an Open, Longitudinal Study
Schoenen, Jean ULg; Bulcke, J.; Caekebeke, Jo et al

in Cephalalgia : An International Journal of Headache (1994), 14(1), 55-63

In a multicenter open longitudinal clinical trial where 479 patients suffering from migraine with or without aura were recruited, patients treated at home one to three migraine attacks with their ... [more ▼]

In a multicenter open longitudinal clinical trial where 479 patients suffering from migraine with or without aura were recruited, patients treated at home one to three migraine attacks with their customary treatment, and subsequently, over a 3-month period, one to three migraine attacks with 6 mg sumatriptan sc using an autoinjector. The headache response to customary treatment was 19% at 1 h and 30.5% at 2 h, and was not significantly different when only attacks treated "adequately" according to accepted treatment recommendations were considered: 16% at 1 h and 35% at 2 h. In contrast, 69% and 82% of patients treated with 6 mg sumatriptan sc had mild headache or no headache at 1 and 2 h respectively, regardless of migraine type or duration of symptoms prior to treatment. Other migraine symptoms (nausea, vomiting, photo- and phonophobia) were effectively treated with sumatriptan. Recurrence of migraine was observed in 31% of patients and was well controlled by a second injection of sumatriptan. It is concluded that 6 mg sumatriptan sc, self-administered using an autoinjector, is well tolerated and more effective than most currently used acute treatments for migraine in a population of severely affected patients consulting a neurologist. [less ▲]

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See detailLes traitements physiques des eaux dures.
Marcoen, Jean Marie ULg; Lédion, J.

in Tribune de l'Eau (La) (1994), 47

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See detailEffects of Alpha-Hederin, a Saponin Extracted from Hedera Helix, on Cells Cultured in Vitro
Danloy, S.; Quetin-Leclercq, J.; Coucke, P. et al

in Planta Medica (1994), 60(1), 45-9

In this work, we have analysed the effects of alpha-hederin, a monodesmosidic triterpenoid saponin isolated from Hedera helix, on mouse B16 melanoma cells and non-cancer mouse 3T3 fibroblasts cultured in ... [more ▼]

In this work, we have analysed the effects of alpha-hederin, a monodesmosidic triterpenoid saponin isolated from Hedera helix, on mouse B16 melanoma cells and non-cancer mouse 3T3 fibroblasts cultured in vitro. Our results indicate that, in a serum-free medium, alpha-hederin is cytotoxic and inhibits proliferation in both cell lines at rather low concentrations (< 5 micrograms/ml) after only 8 hours of treatment. Its cytotoxicity decreases in the presence of serum in which BSA seems to be able to bind the saponin. alpha-Hederin also induces vacuolization of the cytoplasm and membrane alterations leading to cell death. [less ▲]

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See detailCalcul de l'équilibre calcocarbonique des eaux sur calculatrice de poche.
Wuidar, A.; Marcoen, Jean Marie ULg

in Tribune de l'Eau (La) (1994), 47(1), 11-13

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See detailHomeobox Genes: Potential Candidates for the Transcriptional Control of the Transformed and Invasive Phenotype
Castronovo, Vincenzo ULg; Kusaka, Masami; Chariot, Alain ULg et al

in Biochemical Pharmacology (1994), 47(1), 137-43

The transformation of a cell and the acquisition of the invasive and metastatic phenotype result from the activation of a group of complex cellular processes rather than from the effect of a single gene ... [more ▼]

The transformation of a cell and the acquisition of the invasive and metastatic phenotype result from the activation of a group of complex cellular processes rather than from the effect of a single gene product. It is likely that the coordination of the multiple genes involved in malignancy is under the control of a few genes that act as master genes or orchestrator genes. The latter probably code for transcription factors that control the genetic program for tumor invasion and metastasis. Homeobox genes are a family of transcription factors that contain a 183 bp highly conserved nucleotide sequence coding for a 61 amino acid domain that binds specifically to DNA. First discovered in Drosophila as genes controlling segmentation and segment identity, homeobox genes have since been identified in many other species including nematodes, frog, mouse and human. There is strong support for the suggestion that homeobox genes play a key role in development and differentiation. In humans, there are 38 homeobox genes organized in four clusters that are localized on chromosomes 2, 7, 12 and 17. The specific functions of each of these genes are generally unknown. Alterations in expression of several homeobox genes have been reported in a variety of malignant lesions, suggesting that they could play a role in the development of cancer. Using reverse transcriptase reaction coupled with polymerase chain reaction and degenerate oligonucleotides corresponding to the 5' and 3' ends of the highly conserved homeodomain, we amplified 130 bp cDNA fragments from the human breast cancer cell line MCF7 that were subsequently cloned into pBluescript vector. Sequencing of the clones, resulted in the identification of the homeodomains of four different human homeobox genes: HOXB6, HOXA1, HOXA10 and HOXC6. Further studies should determine the specific role of these four homeobox genes in the development and progression of human breast cancer and potentially determine if they might be good targets for gene therapy. [less ▲]

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See detailThe Nf-Kappa B Transcription Factor and Cancer: High Expression of Nf-Kappa B- and I Kappa B-Related Proteins in Tumor Cell Lines
Bours, Vincent ULg; Dejardin, Emmanuel ULg; Goujon-Letawe, F. et al

in Biochemical Pharmacology (1994), 47(1), 145-9

NF-kappa B is a pleiotropic transcription factor which controls the expression of many genes and viruses. To date, there is good evidence, but no definitive proof, for its role in tumor formation and ... [more ▼]

NF-kappa B is a pleiotropic transcription factor which controls the expression of many genes and viruses. To date, there is good evidence, but no definitive proof, for its role in tumor formation and development of metastasis. To investigate the possibility that members of the NF-kappa B family could participate in the molecular control of the transformed and invasive phenotype, we examined the expression of these proteins in a variety of human tumor cell lines. The expression of p50, p65, p52 and I kappa B was quantified at the protein level using western immunoblot and mobility shift assay and at the RNA level by northern blot. We observed high expression of the NF-kappa B inhibitor I kappa B in the ovarian carcinoma cell line OVCAR-3 together with constitutive nuclear NF-kappa B activity. We also studied the colon carcinoma cell line HT-29 and its metastatic counterpart HTM-29 and we observed specific expression of the p52 NF-kappa B-related protein in the metastatic cells. Our data confirm that NF-kappa B could be involved in the genesis of a variety of cancers including solid tumors and provide us with interesting models to explore the exact role of these transcription factors in cancer. [less ▲]

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See detailHypnose, hypnosédation. Conceptions actuelles et leurs applications en chirurgie plastique
Faymonville, Marie-Elisabeth ULg; Fissette, Jean ULg; Mambourg, P. H. et al

in Revue Médicale de Liège (1994), 49(1), 13-22

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See detailTransplantations de tumeurs malignes insoupçonnées lors de greffes d'organes
Detry, Olivier ULg; Detroz, Bernard ULg; D'Silva, M. et al

in Revue Médicale de Liège (1994), 49(1), 23-31

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See detailEvidence for violent ejection of nebulae from massive stars
Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1994), 281(Letters), 81-84

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central ... [more ▼]

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central stars. This correlation holds for both the dust and ionized gas masses of the nebulae. The existence of a 'nebular mass-stellar luminosity' relation and the fact that not all LBVs are presently associated with a nebula give evidence against a continuous mass-loss mechanism for the formation of these nebulae. Further, the good agreement found between the observed relation and predictions by Maeder (1989), suggests that all these nebulae may be due to a violent ejection of matter caused by an instability of structural origin. [less ▲]

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See detailLe pied diabétique: etiopathogénie, prévention et traitement
Van Damme, Hendrik ULg; Paquet, Philippe ULg; Maertens de Noordhout, B. et al

in Revue Médicale de Liège (1994), 49(1), 1-13

-Le pied diabétique est la conséquence des altérations dégénératives du système vasculonerveux observées dans un diabète de longue durée. La neuropathie diabétique est le facteur essentiel dans la plupart ... [more ▼]

-Le pied diabétique est la conséquence des altérations dégénératives du système vasculonerveux observées dans un diabète de longue durée. La neuropathie diabétique est le facteur essentiel dans la plupart des cas, responsable d'hypoalgésies, microtraumatismes et ulcérations, déformation du pied (amyotrophie), et d'une eutosympethectomie (peau sèche, fissurée). Une macroangiopathie (médiacalcinose, occlusions artérielles périphériques) n'est retrouvée que dans 30 % des cas. Une microangiopathie compromet la trophicité des tissus et ralentit leur cicatrisation. Enfin, tout diabétique présente une susceptibilité élevée aux infections. Cette multitude de facteurs en cause impose des mesures de prévention. Un équilibre du profil glycémique retardera les atteintes vasculo-nerveuses. L'hygiène du pied consistera en bains de pieds, soins d'ongles et d'hyperkératoses, chaussures adaptées. En cas de troubles trophiques, une décharge d'appui sers nécessaire. Une désinfection rigoureuse, associée à une antibiothérapie (après prélèvement, si possible) aidera à éviter l'évolution vers l'abcès profond. La moindre collection sera drainée, après excision large des tissus nécrotiques. Les nécroses sèches (talons, orteils) traduisent souvent une artériopethie, pour laquelle un geste de revascularisation (protondoolestie; pontage distal) pourra être pris en considération. Parfois, l'état septique du patient, ou l'étendue de la gangrène, imposera une amputation. L'approche du pied diabétique doit toujours être multidisciplinaire (diabétologue, dermatologue, orthésiste, orthopédiste, chirurgien vasculaire), et doit commencer par des mesures préventives. [less ▲]

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See detailPhotometric variations of Ap stars
Manfroid, Jean ULg; Renson, Pierre ULg

in Astronomy and Astrophysics (1994), 281

The photometric variations of seven Ap stars have been analyzed from observations mainly obtained in the framework of the Long-Term Photometry of Variables project at European Southern Observatory (ESO ... [more ▼]

The photometric variations of seven Ap stars have been analyzed from observations mainly obtained in the framework of the Long-Term Photometry of Variables project at European Southern Observatory (ESO). New values for the periods and detailed light curves in the uvby system are provided. Alpha Scl is shown to display anomalous variations that set it apart from the other stars. [less ▲]

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See detailFurther observational evidence that MG J0414+0534 is a gravitational mirage
Angonin-Willaime, M.-C.; Vanderriest, C.; Hammer, F. et al

in Astronomy and Astrophysics (1994), 281

Deep imaging of MG J0414+0534 with R and I filters reveals a faint, fuzzy and red object at the exact location expected for a lensing galaxy in the gravitational mirage hypothesis. Furthermore, the ... [more ▼]

Deep imaging of MG J0414+0534 with R and I filters reveals a faint, fuzzy and red object at the exact location expected for a lensing galaxy in the gravitational mirage hypothesis. Furthermore, the (extremely red and almost featureless) spectra of the 2 brightest components are very similar. These are strong indications that the system results from multiple gravitational imaging of a single source, but the nature of this source is not yet clear. It could be the nucleus of a low metallicity galaxy at a high redshift or a new type of object. Significant differences are observed between the flux ratios of the images at radio and optical wavelenghts. The most likely explanation for this effect is a differential amplification of the image pair A[SUB]1[/SUB]-A[SUB]2[/SUB] because of the large magnification gradient near a caustic. [less ▲]

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See detailLa tribologie, une spécialité liégeoise
Bozet, Jean-Luc ULg

in Athena (1994), 97

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See detailEffects of Apomorphine on Sexual Behavior in Male Quail
Absil, Philippe ULg; Das, S.; Balthazart, Jacques ULg

in Pharmacology, Biochemistry & Behavior (1994), 47(1), 77-88

In the rat, dopamine (DA) facilitates male copulatory behavior. Indirect evidence based largely on neuroanatomical data suggest that in quail DA is also implicated in the control of male reproductive ... [more ▼]

In the rat, dopamine (DA) facilitates male copulatory behavior. Indirect evidence based largely on neuroanatomical data suggest that in quail DA is also implicated in the control of male reproductive behavior but there is no pharmacological evidence to support this conclusion. To test this idea, castrated testosterone (T)-treated male quail were injected with various doses of the dopaminergic agonist apomorphine (APO) in the range 1-10,000 micrograms/kg. The sexual behavior of birds was recorded starting 15 min after APO injection for a duration of 30 min. A dose-dependent inhibition of male reproductive behavior that lasted for the entire duration of the test was observed. In a second experiment, gonadectomized T-treated male Japanese quail were injected daily with APO (0, 10, or 1,000 micrograms/kg) during 8 days. Their sexual interactions with a partner were quantified either 24 h or 15 min after the last injection. No influence of the treatment on copulatory behavior was observed 24 h after the last injection, but a strong inhibition was present when the test was performed 15 min after. To research whether the inhibitory effects of APO were due to a preferential action on D2 presynaptic autoreceptors, male quail were pretreated with two different D2 antagonists (spiperone or pimozide; 0.5 or 2 mg/kg) before being injected with APO (100 micrograms or 1 mg/kg). Spiperone facilitated male sexual behavior but did not suppress the inhibitory effect of APO. No significant effect of pimozide was observed. These results support the notion that DA modulates male sexual activity in the Japanese quail. The specific role of the different dopaminergic receptor subtypes remains, however, to be elucidated. [less ▲]

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See detailLe point sur la production d’embryons in vitro: limitations et perspectives de la recherche
Thonon, Fabienne; Ectors, Fabien ULg; Delval, Alain et al

in Annales de Médecine Vétérinaire (1994), 138(1), 33-40

Recent progress in gamete biology and early embryo development was responsible for great evolution of reproduction techniques in farm animals. Among these techniques, in vitro production of bovine embryos ... [more ▼]

Recent progress in gamete biology and early embryo development was responsible for great evolution of reproduction techniques in farm animals. Among these techniques, in vitro production of bovine embryos was developed from slaughterhouse ovaries. This method has been used for individual animals. However, large variations in results were observed, due to several factors, including reproductive state and age of the donor. Inspite of this limitation, in vitro production of bovine embryos may be helpful, when slaughtering of valuable cows is recommended eg for brucellosis disease. Researches are purchased in order to increase the number of oocytes obtained per "elite" cow and to improve the ability of in vitro embryos to support freezing. [less ▲]

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See detailEffects of Acute Injection of Methylprednisolone in Man on Immunological and Non-Immunological Histamine Release from Leucocytes and Its Potentiation by Interleukin-3
Louis, Renaud ULg; Bury, Thierry ULg; Corhay, Jean-Louis ULg et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (1994), 24(1), 60-5

We investigated the effects of intravenous injection of methylprednisolone (MPR) compared with placebo (saline) on ex vivo leucocytic histamine release in eight healthy volunteers. All subjects received ... [more ▼]

We investigated the effects of intravenous injection of methylprednisolone (MPR) compared with placebo (saline) on ex vivo leucocytic histamine release in eight healthy volunteers. All subjects received in a randomized and a single-blind manner the placebo and MPR, 20 mg and 125 mg, each injection given in 2 week intervals. On each occasion blood samples were taken just before and 24 h after the intravenous injection to determine circulating leucocyte counts and leucocytic histamine release induced by anti-IgE (1/2000) and FMP (Formyl-Methionyl-Phenylalanine) (10(-5) M) and its modulation by IL-3 (2 ng/ml). MPR 20 mg and 125 mg significantly increased circulating leucocyte counts (P < 0.05 and P < 0.001 respectively) but decreased leucocytic histamine content (P < 0.05 and P < 0.001 respectively) by 24 h. Placebo had no effect. As for circulating basophils, after 24 h they were decreased by 125 mg MPR (P < 0.05) but increased by 20 mg (P < 0.05). Anti-IgE-induced HR was significantly inhibited by 125 mg MPR (P < 0.05) but not by 20 mg MPR or by the placebo. In contrast, neither MPR (20 mg and 125 mg) nor placebo significantly reduced FMP-induced HR. The strong potentiation by IL-3 of HR evoked by anti-IgE and FMP at baseline (P < 0.001) persisted 24 h after injection of MPR or placebo (P < 0.001 except P < 0.05 for anti-IgE-induced HR after 125 mg MPR).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailLong-Term (3 Years) Prevention of Trabecular Postmenopausal Bone Loss with Low-Dose Intermittent Nasal Salmon Calcitonin
Reginster, Jean-Yves ULg; Denis, D.; Deroisy, Rita ULg et al

in Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research (1994), 9(1), 69-73

The long-term effect of intermittent low-dose nasal salmon calcitonin on trabecular early postmenopausal bone loss was assessed as follow-up to a previously published study. Randomized controlled group ... [more ▼]

The long-term effect of intermittent low-dose nasal salmon calcitonin on trabecular early postmenopausal bone loss was assessed as follow-up to a previously published study. Randomized controlled group comparison was made of 287 healthy women with 6-36 months of natural menopause and no treatment interfering with calcium metabolism at an outpatient clinic for research in bone and cartilage metabolism. The 287 women were randomly allocated to 3 years of treatment with either 500 mg/day, 5 days/week of calcium or the same amount of calcium plus 50 IU/day, 5 days per week of nasal salmon calcitonin. A total of 186 women complied with the study protocol throughout. The main outcome measures were bone mineral density of the lumbar spine (DPA) and biochemical parameters reflecting bone turnover (serum alkaline phosphatases, urinary calcium/creatinine, and hydroxyproline/creatinine ratio). The average changes in bone mineral density after 36 months showed a positive (p < 0.05) outcome (1.8 +/- 5.7%; mean +/- SD) in the group treated with salmon calcitonin and calcium and a significant (p < 0.01) loss (-5.8 +/- 4.8%) in patients receiving calcium alone. The difference between the evolution of the two groups was significantly (p < 0.01) different after 6 months of treatment and remained so until the end of the study. No significant changes were recorded in biochemical parameters reflecting bone turnover. As previously shown during a 1 year follow-up, nasal salmon calcitonin given at low dose and intermittently, in association with calcium, can counteract trabecular postmenopausal bone loss. [less ▲]

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See detailAnaphylatoxin C5a Production During Short-Term Submaximal Dynamic Exercise in Man
Camus, G.; Duchateau, J.; Deby, Ginette ULg et al

in International Journal of Sports Medicine (1994), 15(1), 32-5

We studied the effects of short-term submaximal exercise on the plasma levels of myeloperoxidase ([MPO]) and C5a anaphylatoxin ([C5a]), taken as specific markers of polymorphonuclear neutrophil (PMN) and ... [more ▼]

We studied the effects of short-term submaximal exercise on the plasma levels of myeloperoxidase ([MPO]) and C5a anaphylatoxin ([C5a]), taken as specific markers of polymorphonuclear neutrophil (PMN) and complement activation, respectively. Eleven young, healthy male volunteers were subjected to a constant-load concentric exercise on a cycle ergometer (20 min at 80% maximal oxygen uptake). Mean resting MPO and C5a concentrations were 437 +/- 113 and 0.47 +/- 0.21 ng/ml, respectively. During exercise, [MPO] and [C5a] increased significantly (p < 0.001) towards respective peak values of 649 +/- 131 and 1.3 +/- 0.6 ng/ml. A rapid decrease of both [MPO] and [C5a] was observed during recovery. The similar time course of [MPO] and [C5a] changes and the highly significant relationship between these two variables (r = 0.651; p < 0.001) argues for the possible involvement of the complement anaphylatoxin C5a in the process of PMN degranulation. During exercise, the number of circulating PMN increased (+80%; p < 0.001) and remained practically unchanged up to 20 minutes of recovery. As [MPO] and PMN count were not significantly related (r = 0.2; p < 0.1), we concluded that the activation of PMN was independent of their mobilization. [less ▲]

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See detailDetection of Human Papillomaviruses in Paraffin-Embedded Biopsies of Cervical Intraepithelial Lesions: Analysis by Immunohistochemistry, in Situ Hybridization, and the Polymerase Chain Reaction
Delvenne, Philippe ULg; Fontaine, Marie-Anne; Delvenne, Catherine ULg et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (1994), 7(1), 113-119

One hundred and forty biopsies with an initial diagnosis of cervical intraepithelial lesion (CIL) were tested for the presence of human papillomavirus (HPV) by immunohistochemistry and in situ ... [more ▼]

One hundred and forty biopsies with an initial diagnosis of cervical intraepithelial lesion (CIL) were tested for the presence of human papillomavirus (HPV) by immunohistochemistry and in situ hybridization using commercial biotinylated probes (Vira-Type in situ assay; Digene Diagnostics, Silver Spring, MD) or probes labeled with digoxigenin by the random primer technique. Immunohistochemistry was more inferior to the in situ hybridization method, with a detection rate of 14% (20/140) compared to 61% (86/140) for the in situ assay with the digoxigenin-labeled probes. Biotinylated probes proved to be slightly less sensitive than digoxigenin-labeled probes, with a detection rate of 53% (74/140). Although less sensitive in our series taken as a whole, immunohistochemistry was positive in a few cases of CILs negative by in situ hybridization, so that the association of these techniques gave the highest detection rate (66%; 92/140). The CILs that remained negative with these methods (34%; 48/140) were investigated by the polymerase chain reaction (PCR) using consensus primers to determine definitively the presence of HPV in these lesions and were reviewed histologically to assess the diagnosis of CILs. The PCR method increased the detection rate of HPV in our series to 76% (107/140). The diagnosis of CILs was confirmed for all the biopsy specimens positive by PCR (15/15; 100%) and for all the HPV negative tissues with histological features of a high-grade lesions (7/7; 100%).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailEloge de Marcel Migeotte (1912-1992)
Biémont, Emile ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1994), V(6), 271-278

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See detailGenetic diversity among some wild populations of lima bean (Phaseolus lunatus L.) proceeding from Central Valley of Costa Rica
Maquet, Alain; Wathelet, Bernard ULg; Dubois, Sophie et al

in Annual Report of the Bean Improvment Cooperative (1994)

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See detailLa gestion des données avec le logiciel V. M. S.
Claustriaux, Jean-Jacques ULg; Deltenre, Alain

in Notes de Statistique et d'Informatique (1994), 2

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See detailBI-BASED 2223 SUPERCONDUCTING POLYCRYSTALLINE MATERIALS PREPARED BY EITHER A SOLID-STATE ROUTE OR A GLASSY MATRIX PRECURSOR METHOD - CHEMICAL-ANALYSIS AS WELL AS ELECTRICAL AND THERMAL TRANSPORT-PROPERTIES
Cloots, Rudi ULg; Bougrine, Hassan ULg; HOUSSA, M. et al

in Physica C (1994), 231(3-4), 259-270

Two routes have been followed in order to prepare Bi1.7Pb0.3Sr2Ca2Cu3O(y) superconducting materials. Bi1.7Pb0.3CuO4 is always used as one of the starting basic materials. The first route involves a new ... [more ▼]

Two routes have been followed in order to prepare Bi1.7Pb0.3Sr2Ca2Cu3O(y) superconducting materials. Bi1.7Pb0.3CuO4 is always used as one of the starting basic materials. The first route involves a new experimental procedure based on the solid state synthesis of separate intermediate phases, mixed together in a two (Bi1.7Pb0.3CuO4 + 2SrCaCuO3), three (Bi1.7Pb0.3CuO4+2SrCuO2+2CaCO3) or four (Bi1.7Pb0.3CuO4+(1/12)Sr8Ca6Cu24O41 + (3/2)CaCO3 + (4/3)SrCO3) powder process. Electric resistivity versus temperature measurements are presented. Even though the T(c)(0) of each sample is above 100 K, X-ray diffraction shows that the main phase is the 2212 phase in each case. Relatively pure 2223 materials have, however, successfully been produced by the second method, which starts from a glassy intermediate phase and involves a so-called 'matrix' method. The glass precursor phase is composed of one (Bi1.7Pb0.3CuO4), two (Bi1.7Pb0.3CuO4 + 2CaCO3), and three (Bi1.7Pb0.3CuO4 + (3/2)CaCO3 + (4/3)SrCO3) components as for the solid state routes. The role of both the added alkaline earth crystalline compounds and the glass matrix precursors in this second method turns out to be very important. We propose a schematic structural model in order to explain the selectivity of the starting materials. SrCaCuO3 is found to be a good precursor of the 2212 phase, while SrCuO2 gives rise to the 2223 phase. It seems that the presence of CaCO3 in the glassy intermediate phase, thus acting as a cation reservoir, is very useful for the production of the 2223 phase. Electric resistivity, thermal conductivity and thermopower versus temperature measurements are also presented and discussed in terms of intergrowths and variations of cationic compositions in the Bi-based layers. [less ▲]

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See detailThe mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.
Wilkin, J M; Dubus, Alice ULg; Joris, Bernard ULg et al

in Biochemical Journal (1994), 301 ( Pt 2)

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the ... [more ▼]

The side chains of residues Thr299 and Thr301 in the Streptomyces R61 DD-peptidase have been modified by site-directed mutagenesis. These amino acids are part of a beta-strand which forms a wall of the active-site cavity. Thr299 corresponds to the second residue of the Lys-Thr(Ser)-Gly triad, highly conserved in active-site beta-lactamases and penicillin-binding proteins (PBPs). Modification of Thr301 resulted only in minor alterations of the catalytic and penicillin-binding properties of the enzyme. No selective decrease of the rate of acylation was observed for any particular class of compounds. By contrast, the loss of the hydroxy group of the residue in position 299 yielded a seriously impaired enzyme. The rates of inactivation by penicillins were decreased 30-50-fold, whereas the reactions with cephalosporins were even more affected. The efficiency of hydrolysis against the peptide substrate was also seriously decreased. More surprisingly, the mutant was completely unable to catalyse transpeptidation reactions. The conservation of an hydroxylated residue in this position in PBPs is thus easily explained by these results. [less ▲]

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See detailEffect of dopamine and baclofen on N-methyl-D-aspartate-induced burst firing in rat ventral tegmental neurons.
Seutin, Vincent ULg; Johnson, S. W.; North, R. A.

in Neuroscience (1994), 58(1), 201-6

Intracellular microelectrode recordings were made from dopamine-containing neurons of the ventral tegmental area or substantia nigra zona compacta in rat brain slices in vitro. The firing pattern of the ... [more ▼]

Intracellular microelectrode recordings were made from dopamine-containing neurons of the ventral tegmental area or substantia nigra zona compacta in rat brain slices in vitro. The firing pattern of the neurons was switched from a tonic, single-spike pattern to a burst firing mode by adding N-methyl-D-aspartate (20 microM) to the superfusing solution; after adding tetrodotoxin the membrane potential underwent rhythmical oscillations of 20-40 mV at 0.5-2 Hz. Baclofen (1 microM) and dopamine (30 microM) hyperpolarized the neurons; when the potential was restored to its original level, the oscillations of potential and/or burst firing were not observed, but the tonic firing pattern was restored. These effects of baclofen and dopamine were prevented by barium (1 mM), which also prevented the membrane hyperpolarization. Oscillations of membrane current of a similar frequency were observed when the somatic membrane was voltage-clamped at -60 mV; these were also blocked by barium (1 mM). It is concluded that the oscillations in membrane potential observed with N-methyl-D-aspartate are generated predominantly at a dendritic location which is not voltage-clamped with an electrode at the soma. Baclofen and dopamine inhibit the oscillations by increasing the potassium conductance and hyperpolarizing the dendrites. [less ▲]

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See detailEnzyme Immobilization in Nanoparticles produced by Inverse Microemulsion Polymerization
Daubresse, Catherine; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Colloid & Interface Science (1994), 168

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See detailLe tamoxifene dans le traitement du cancer du sein
Charlier, Corinne ULg; Colin, Claude ULg; Merville, Marie-Paule ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(7), 751-6

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on ... [more ▼]

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on oral adjuvant therapy in the early stages of breast cancer. A significative regression of the tumour was observed in most cases. Moreover, recent epidemiological studies suggest that tamoxifen could prevent new contralateral primary tumours. The risk of the disease should thus be reduced by the prophylactic use of antioestrogens such as tamoxifen. Investigations using a variety of models have evaluated the effect of tamoxifen on tumour promotion and cell growth. Tamoxifen-induced growth inhibition is associated with major changes in biochemical events in cultured human breast cancer cells including cell proliferation or growth factor production. Growth inhibition of oestrogen-responsive human breast cancer cells is associated with an induced secretion of autoinhibitory polypeptides (TGF beta) and an antagonistic effect on the synthesis of proliferative proteins (TGF alpha,...). The first step in the mechanism of action of the drug is binding of tamoxifen to the oestrogen receptors. Development of resistance to tamoxifen treatment is a great problem in treatment of breast cancer patients and the mechanism of resistance will require further study: under the influence of the drug, tumours could become remodelled as selected subpopulations emerge resistant-tamoxifen. The fact that some breast cancers which are oestrogen receptor-negative respond to antioestrogen suggests that parallel but separate pathways for oestrogen and antioestrogen action may exist. This paper summarizes the results of the most recent studies concerning this promising drug. [less ▲]

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See detailA thyroid hormone receptor-dependent glucocorticoid induction.
Leers, Joerg; Steiner, Christoff; Renkawitz, Rainer et al

in Molecular Endocrinology (Baltimore, Md.) (1994), 8(4), 440-7

Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to ... [more ▼]

Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to the discovery of synergism between a thyroid hormone receptor-binding site and a cryptic glucocorticoid-responsive element. Glucocorticoid responsiveness could only be detected in the presence of thyroid hormone and its receptor. This synergism requires the glucocorticoid receptor (GR) DNA-binding domain and is mediated by the transactivation domains. We found that synergism also occurs when the thyroid hormone receptor is replaced by the retinoic acid receptor or the GR is replaced by the progesterone receptor. Synergism is qualitatively independent of the type of thyroid hormone receptor-binding site and promoter. In several combinations of promoter and response elements, including a retinoic acid response element, T3 induction was only seen in the presence of the cryptic glucocorticoid-responsive element, GR, and glucocorticoids. [less ▲]

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See detailShape processing and analysis using the calypter
Pirard, Eric ULg

in Journal of Microscopy (1994), 175(3), 214-221

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See detailOvarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage.
Donnez, Jacques; NISOLLE, Michelle ULg; Gillerot, Stéphane et al

in Fertility and Sterility (1994), 62(1), 63-6

Objective: To evaluate the role of GnRH agonist (GnRH-a) and/or drainage in the management of large endometriomas. DESIGN: This prospective clinical study was conducted in a parallel and randomized design ... [more ▼]

Objective: To evaluate the role of GnRH agonist (GnRH-a) and/or drainage in the management of large endometriomas. DESIGN: This prospective clinical study was conducted in a parallel and randomized design. SETTING: Department of Gynecology, Cliniques Universitaires St. Luc, Brussels, Belgium. PATIENTS: Eight infertile women with laparoscopically confirmed ovarian endometriotic cysts. After laparoscopic drainage of the ovarian cyst, patients were randomized. Patients in group I (n = 40) received no therapy. Patients in group II (n = 40) received GnRH-a therapy for 12 weeks. A second-look laparoscopy was performed after 12 weeks in each woman. RESULTS: After drainage, a quick recurrence of the endometrial cyst was observed in only group I. Indeed, the score and the cyst size were similar to the values observed before the first laparoscopy. In group II, a significant decrease in score and cyst diameter was observed. Ovarian biopsies revealed significant reduction in the stromal vascularization and a significant reduction in the mitotic activity in the group of women treated with GnRH-a. CONCLUSION: The quick recurrence of the ovarian cyst after drainage proved that drainage alone is ineffective. Drainage followed by GnRH-a was effective in the reduction of cyst size and the glandular mitotic activity. [less ▲]

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See detailGreffes de moelle dans les hémoglobinopathies
Beguin, Yves ULg

in Mini Acta (1994), 26

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See detailAdvanced endoscopic techniques used in dysfunctional bleeding, fibroids and endometriosis, and the role of gonadotrophin-releasing hormone agonist treatment.
Donnez, Jacques; NISOLLE, Michelle ULg; Clerckx, Françoise et al

in British Journal of Obstetrics & Gynaecology (1994), 101(suppl 10), 2-9

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See detailQuantitative Assessment of Aerial Ammonia Toxicity to the Nasal Mucosa by Use of the Nasal Lavage Method in Pigs
Urbain, B.; Gustin, Pascal ULg; Prouvost, J. F. et al

in American Journal of Veterinary Research (1994), 55(9), 1335-1340

Effects of atmospheric ammonia (NH3) on the nasal mucosa and somatic growth were investigated in pigs exposed to 4 NH3 concentrations (0; 25; 50; and 100 ppm) for 6 days in a specifically designed air ... [more ▼]

Effects of atmospheric ammonia (NH3) on the nasal mucosa and somatic growth were investigated in pigs exposed to 4 NH3 concentrations (0; 25; 50; and 100 ppm) for 6 days in a specifically designed air-pollutant exposure chamber. Nasal lavage (NAL) was applied to quantify the ammonia-induced inflammatory response by measuring the number of neutrophils and the albumin (porcine serum albumin) concentration in the NAL liquid. In control pigs, these variables remained unchanged throughout the exposure period. In all other groups, an important ammonia concentration-related increase was recorded. The equation of the linear regression line established between the mean values of the number of neutrophils (x 10(3)) per milliliter of NAL liquid (y) recorded at the end of the exposure period and the ammonia concentrations (ppm) was: y = 69.7 + 3.3 [NH3] (r = 0.979; P < 0.020). The increase in the neutrophil count was significant (P < 0.05) at concentrations as low as 25 ppm. For albumin concentration nanograms per milliliter, the corresponding equation was: y = 574 + 14.3 [NH3] (r = 0.953; P < 0.045). However, the first significant change (P < 0.05) in this variable was only obtained for the higher concentration (100 ppm). In exposed pigs, a concentration-related depression of somatic growth was observed. The equation of the regression line plotted relating the individual values of the changes in body weight gain recorded over the exposure period expressed as percentage of the initial body weight (y) and the ammonia concentration was: y = 3.507-0.203 [NH3] + 0.001 [NH3]2 (r = 0.55; P < 0.010).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailFouilles 1994 à l'Abri du Pape et à la Grotte du Bois Laiterie (Province de Namur)
Otte, Marcel ULg; Straus, Lawrence; Lacroix, Philippe et al

in Notae praehistoricae (1994), 14

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See detailLiège vue par une géographe
Merenne-Schoumaker, Bernadette ULg

in Cahiers de Clio (1994), (120), 5-16

Présentation générale de Liège

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See detailExperimental Models of Inflammatory Bowel Disease
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1994), 57(5-6, Sep-Dec), 306-9

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced ... [more ▼]

Etiology of inflammatory bowel disease (IBD) is still unknown. A lot of experimental models of these diseases have been developed during the last years. They can be classified as spontaneous and induced models. Spontaneous models are infectious, genetic or of unknown etiology. Induced models are infectious, immune-mediated, chemical or genetic. All these models share some characteristics with IBD. In general, they are characterized by a chronic inflammation of the gut, and often, this inflammation appears secondary to mucosal abnormalities leading to an abnormal immune and inflammatory response toward luminal material. The most interesting models are thus those that share not only clinical and pathological characteristics with IBD, but also early mucosal abnormalities. From that point of view, the nonsteroidal anti-inflammatory drug (NSAID) enteropathy is probably one of the most interesting model for Crohn's disease (CD). In effect, this model shares an early modification with CD, that is increased intestinal permeability. In animals NSAID enteropathy, the increased intestinal permeability appears early after NSAID administration and is followed by inflammatory lesions. These lesions seem to be secondary to the increased permeability and depend on intraluminal materials, such as alimentary antigens or bacterial fragments. A possible link between the increased permeability and the inflammatory lesions could be an abnormal immune and inflammatory response toward the intraluminal materials. If the increased intestinal permeability in CD was confirmed, the same mechanisms could be implicated in its pathophysiology. [less ▲]

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See detailOnce-a-day administration of amikacin in neonates: clinical evidence of the validity of a pharmacokinetic according to the gestational age
Battisti, Oreste ULg; Wallemacq P; Langhendries JP

in Early Human Development (1994), 38

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See detailMutation analysis of coding sequences for type I procollagen in individuals with low bone density.
Spotila, L. D.; Colige, Alain ULg; Sereda, L. et al

in Journal of Bone and Mineral Research (1994), 9(6), 923-32

Mutations in one of the two genes encoding type I procollagen (COL1A1 and COL1A2) are frequently the cause of osteogenesis imperfecta (OI), a disorder characterized by brittle bones. Here we tested ... [more ▼]

Mutations in one of the two genes encoding type I procollagen (COL1A1 and COL1A2) are frequently the cause of osteogenesis imperfecta (OI), a disorder characterized by brittle bones. Here we tested whether patients with low bone density also have mutations in these genes. The 26 patients studied had no apparent metabolic bone disease, but most had a positive family history of osteopenia or osteoporosis. Although a diagnosis of OI was considered by the clinician in some cases, the clinical criteria for OI were not satisfied. Our strategy for mutation analysis consisted of PCR amplification of cDNA made to fibroblast mRNA using primers specific for the coding regions of COL1A1 and COL1A2. The PCR products were then sequenced directly with primers located within each PCR product. We found that 3 of 26 patients had mutations that altered the encoded amino acid. One mutation, at position alpha 2(I)-661 has been reported (Spotila et al. 1991 Proc Natl Acad Sci USA PNAS 88:5423). The other 2 patients, who were not related to each other, had a mutation that altered the proline codon at alpha 1(I)-27 to alanine. This mutation was not found in 81 normal individuals or in 37 additional osteopenic individuals. However, its effect on the biologic function of type I collagen, as well as its role in osteopenia, is uncertain. In addition to the two mutations, we found a polymorphism in codon alpha 2(I)-459. Although this polymorphism involved an amino acid substitution, it was present with equal frequency in the patient and the normal population. By analyzing this and previously reported neutral sequence variants in the COL1A2 gene, we determined that all patients expressed both alleles of the COL1A2 gene. The 12 patients who were heterozygous for a COL1A1 neutral sequence variant also expressed both alleles. Here we present all PCR primer and sequencing primer information. The results suggest that surveying a larger group of similarly selected individuals may reveal additional mutations in the COL1A1 or COL1A2 genes. [less ▲]

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See detailL'inventaire forestier régional wallon: brève présentation méthodologique.
Lecomte, H.; Rondeux, Jacques ULg

in Silva Belgica (1994), 101(6), 9-16

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie ... [more ▼]

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie [RONDEUX et al., 1984]. Cet inventaire s’appuyant sur un échantillonnage systématique simple était destiné à fournir un état des lieux de la forêt wallonne de l’époque ; il a notamment permis de confirmer ou de mettre en évidence plusieurs éléments essentiels pour l’avenir du patrimoine forestier wallon [RONDEUX et al., 1986] : - le vieillissement de la hêtraie ardennaise ; - l’importante disponibilité en bois d’épicéa ; - les écarts entre les surfaces forestières observées et celles du recensement officiel. Depuis la fin de cet inventaire en 1984, aucune mise à jour n’a été programmée et en conséquence, ses résultats ont perdu leur fiabilité notamment en raison des accidents météorologiques de la dernière décennie. En 1988, l’Exécutif de la Région Wallonne, conscient de l’importance de la forêt en tant que première ressource naturelle renouvelable de la Wallonie, a sollicité la Faculté des Sciences agronomiques de Gembloux en vue de finaliser une recherche destinée à concevoir une méthodologie d’inventaire forestier permanent. Les conclusions de cette étude ont été déposées fin 1993 [LECOMTE, 1994], ce qui a permis de lancer dès février 1994 la phase opérationnelle du premier inventaire forestier permanent pour la Wallonie. Dans les lignes qui suivent, nous aborderons successivement les objectifs de l’inventaire (paragraphe 2) ainsi que les principes généraux qui le régissent (paragraphe 3). Le cheminement de l’information sera décrit depuis la récolte des données (paragraphe 4) jusqu’à la publication des résultats (paragraphe 7) en passant par le traitement et l’exploitation des données (paragraphes 5 et 6). En guise de conclusions, nous émettrons quelques réflexions issues de notre propre expérience (paragraphe 8). [less ▲]

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See detailSubcellular Localization and Compartmentation of Thiamine Derivatives in Rat Brain
Bettendorff, Lucien ULg; Wins, Pierre; Lesourd, Monique

in Biochimica et Biophysica Acta (1994), 1222(1), 1-6

The subcellular distribution of thiamine derivatives in rat brain was studied. Thiamine diphosphate content was highest in the mitochondrial and synaptosomal fractions, and lowest in microsomal, myelin ... [more ▼]

The subcellular distribution of thiamine derivatives in rat brain was studied. Thiamine diphosphate content was highest in the mitochondrial and synaptosomal fractions, and lowest in microsomal, myelin and cytosolic fractions. Only 3-5% of total thiamine diphosphate was bound to transketolase, a cytosolic enzyme. Thiamine triphosphate was barely detectable in the microsomal and cytosolic fraction, but synaptosomes were slightly enriched in this compound compared to the crude homogenate. Both myelin and mitochondrial fractions contained significant amounts of thiamine triphosphate. In order to estimate the relative turnover rates of these compounds, the animals received an intraperitoneal injection of either [14C]thiamine or [14C]sulbutiamine (isobutyrylthiamine disulfide) 1 h before decapitation. The specific radioactivities of thiamine compounds found in the brain decreased in the order: thiamine > thiamine triphosphate > thiamine monophosphate > thiamine diphosphate. Incorporation of radioactivity into thiamine triphosphate was more marked with [14C]sulbutiamine than with [14C]thiamine. The highest specific radioactivity of thiamine diphosphate was found in the cytosolic fraction of the brain, though this pool represents less than 10% of total thiamine diphosphate. Cytosolic thiamine diphosphate had a twice higher specific radioactivity when [14C]sulbutiamine was used as precursor compared with thiamine though no significant differences were found in the other cellular compartments. Our results suggest the existence of two thiamine diphosphate pools: the bound cofactor pool is essentially mitochondrial and has a low turnover; a much smaller cytosolic pool (6-7% of total TDP) of high turnover is the likely precursor of thiamine triphosphate. [less ▲]

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See detailCo-movements and dynamic interrelationships in pacific basin stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza; Urbain, Jean-Pierre ULg

in Research in International Business and Finance (1994), 11B

In this paper, we investigate dynamic interrelationships among the stock markets of Australia, Hong Kong, Japan, New Zealand and Singapore. Using cointegration analysis and the Granger causality test we ... [more ▼]

In this paper, we investigate dynamic interrelationships among the stock markets of Australia, Hong Kong, Japan, New Zealand and Singapore. Using cointegration analysis and the Granger causality test we find that, although the five stock price indices share some common trends, the only stock price which does not apparently Granger cause (precede) the remaining stock prices is that of New Zealand. It is further observed that all price indices are caused by the remaining stock prices except that of Australia. With respect to the geographical separation, it appears that when we consider the Asian countries as an entity and those of the Pacific as another entity, they seem not to influence each other significantly. [less ▲]

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See detailMeaningful Interiors: An Interview with Clark Coolidge
Delville, Michel ULg

in BELL. Belgian Essays on Language and Literature (1994)

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See detailPolylactide Microparticules Prepared by Double Emulsion/Evaporation Technique. I. Effect of Primary Emulsion Stability
Nihant; Schugens, Chantal; Grandfils, Christian ULg et al

in Pharmaceutical Research (1994), 11(10), 1479-1484

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound ... [more ▼]

The process of microencapsulation of proteins by double emulsion-evaporation in a matrix of polylactide (PLA) can be divided into three successive steps: first, an aqueous solution of the active compound is emulsified into an organic solution of the hydrophobic coating polymer; second, this primary water-in-oil (w/o) is dispersed in water with formation of a double water-oil-water emulsion (w/o/w), third, the organic solvent is removed with formation of solid microparticles. This paper focuses of the effect of primary emulsion stability on the morphology and properties of polylactide microparticles loaded with bovine serum albumin (BSA) used as model drug. [less ▲]

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See detailThe use of large scale computer assisted tomography for the study of hydrodynamics in trickling filters
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Chemical Engineering Science (1994), 49(24B), 5271-5280

In this paper, a new experimental technique is proposed, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling filters. Tomography refers to the cross ... [more ▼]

In this paper, a new experimental technique is proposed, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling filters. Tomography refers to the cross-sectional imaging of an object from data collected by illuminating this object from many directions. The experimental set-up allows the scanning of transverse sections of rather large filters: up to 0.8 m diameter and 2 m height can be irradiated. Experiments were carried out both without and with liquid flow. In the absence of liquid, the reconstructed images give a view of the non-uniformity of the solid phase distribution. The images obtained are very complex because they result from the superposition of several distributions with different spatial scales. The existence of a first spatial scale is shown which allows separation of the properties belonging to the individual packing elements from those belonging to the bed scale. When liquid is flowing through the packed bed, the distribution of the liquid hold-up is clearly evidenced, despite the very low liquid film thickness. [less ▲]

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See detailNuclear magnetic resonance spectroscopy : insights into experimental septic shock
GILLES, R; CARLIER, PG; D'Orio, Vincenzo ULg

in Intensive Care Medicine (1994)

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See detailLe paradis d'une ville au siècle de Louis XIV
George, Philippe ULg

in Annales du Cercle Hutois des Sciences et Beaux-Arts (1994), XLVIII

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See detailMalignant Hyperthermia and Severe Hypoglycemia after Reexposure to Halothane
Bichel, T.; Canivet, Jean-Luc ULg; Damas, Pierre ULg et al

in Acta Anaesthesiologica Belgica (1994), 45(1), 23-7

A four year child presented with an episode of malignant hyperthermia induced by reexposure to halothane. The episode was associated with early onset of a severe hypoglycemia and liver enzymatic ... [more ▼]

A four year child presented with an episode of malignant hyperthermia induced by reexposure to halothane. The episode was associated with early onset of a severe hypoglycemia and liver enzymatic perturbances. Etiology of these perturbances is hard to state precisely in this clinical context, but a hepatic toxicity of halothane and/or by dantrolene is considered. [less ▲]

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See detailLes écrans de la transparence. Essai de définition sémio-pragmatique du discours télévisuel
Badir, Sémir ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994), 70-71-72

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See detailBioconversion of vanillin into vanillic acid by Pseudomonas fluorescens strain BTP9
Bare, Ghislain; Delaunois, Valérie; Rikir, Rafaelle et al

in Applied Biochemistry and Biotechnology (1994), 45/46

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See detailImproved Experimental and Theoretical Energy Levels of Neon I
Chang, E. S.; Schoenfeld, W. G.; Biémont, Emile ULg et al

in Physica Scripta (1994), 49

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See detailLes transplantations de cellules de Schwann syngéniques dans les lésions médullaires: résultats, limitations et perspectives
Martin, Didier ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1994), 149(5-7), 279-89289-91

After a central nervous system (CNS) injury, there is only an "abortive regeneration" of axons, while injured axons regenerate vividly in the peripheral nervous system (PNS). This difference is due, at ... [more ▼]

After a central nervous system (CNS) injury, there is only an "abortive regeneration" of axons, while injured axons regenerate vividly in the peripheral nervous system (PNS). This difference is due, at least in part, to the existence in the periphery of Schwann cells and of growth promoting proteins they synthetize. One strategy to promote regrowth of central axons can be therefore, to modify (i.e. "peripheralize") the microenvironment by transplanting biologically active Schwann cells into the lesion site. In a rat model of traumatic paraplegia by inflation of a subdural microballoon, we performed syngeneic transplants of Schwann cells. These cells are cultured from adult dorsal root ganglia and can be kept in vitro for several months. They are transplanted in the injured spinal cord. The grafted Schwann cells are well integrated in the host tissue without detectable inflammatory reaction. Cystic cavitation and astrogliosis are reduced in grafted animals as compared to injured, non-grafted animals. The transplant is invaded by abundant, mainly unmyelinated axons which are immunoreactive for substance P, VIP or CGRP, i.e. transmitters known to be present in DRG afferents. Supraspinal afferents containing 5HT, TH or CCK accumulate at the rostral margin of the graft. Experimental procedures trying to stimulate the invasion of the graft by descending fibers, i.e. by inducing a chemoattraction are therefore of crucial importance for functional recovery. [less ▲]

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See detailL'analyse de la variance : une methode d'un autre âge ?
Claustriaux, Jean-Jacques ULg

in Biométrie-Praximétrie (1994), 34(2), 95-107

L'analyse de la variance est une ancienne méthode couramment utilisée pour le traitement statistique des données. Pour certains aspects, l'évolution de son utilisation pratique est présentée.

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See detailInsulin secretion, clearance and action before and after gastroplasty in severely obese subjects.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1994), 18(5), 295-300

This study investigated the effects of a drastic weight reduction on insulin secretion rate (ISR), insulin metabolic clearance rate (MCRI) and insulin sensitivity (SI) in severely obese subjects. A ... [more ▼]

This study investigated the effects of a drastic weight reduction on insulin secretion rate (ISR), insulin metabolic clearance rate (MCRI) and insulin sensitivity (SI) in severely obese subjects. A frequently sampled intravenous glucose tolerance test (FSIVGTT, 0.3 g/kg) was performed before and 8 +/- 1 months after a vertical ring gastroplasty in 12 overnight-fasted obese non-diabetic subjects; the results were compared to those obtained in 12 lean controls matched for age and sex. ISR was derived by deconvolution of plasma C-peptide levels; MCRI was obtained by dividing the area under the curve (AUC180 min) of ISR by the corresponding AUC of plasma insulin levels (IRI); the SI and the glucose effectiveness index (SG) were calculated by Bergman's minimal model. Before gastroplasty, obese subjects showed significantly higher ISR (P < 0.02), lower MCRI (P < 0.001), lower SI (P < 0.001) but similar SG when compared to lean controls. After gastroplasty (reduction of body weight from 104.8 +/- 3.8 to 73.4 +/- 3.6 kg and of BMI from 37.9 +/- 0.8 to 26.5 +/- 0.9 kg/m2; P < 0.001), ISR only decreased from 53,125 +/- 7968 to 42,302 +/- 3716 pmol/180 min (not significant) while AUC-IRI dramatically fell from 53,626 +/- 6378 to 21,111 +/- 2584 pmol.min/l; P < 0.001); consequently, MCRI markedly increased from 526 +/- 96 to 1257 +/- 150 ml/min/m2; P < 0.01). SI significantly rose from 3.12 +/- 0.45 to 7.10 +/- 1.20 x 10(-4) l/mU/min (P < 0.005) while SG remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailMicroencapsulation by coacervation of poly(lactide-co-glycolide): Physico-chemical characteristics of the phase separation process
Stassen, S; Nihant, Nicole; Martin, Véronique et al

in Polymer (1994), 35(4), 777-785

This paper describes the phase separation of different lactide and glycolide copolyester solutions, induced by the addition of silicone oil in order to promote protein microencapsulation. The phase ... [more ▼]

This paper describes the phase separation of different lactide and glycolide copolyester solutions, induced by the addition of silicone oil in order to promote protein microencapsulation. The phase diagrams of the ternary CH2Cl2-copolyester-silicone oil systems were established in relation to the composition of the copolyester and the viscosity, i.e. the molecular weight, of the silicone oil. The phase-separated systems were characterized in terms of weight, volume, composition and viscosity of the coacervation agent (silicone oil) on the characteristics of the phase-separated system is discussed. [less ▲]

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See detailHormonal profile of growing male and female diploïds and triploïds of the blue tilapia, Oreochromis aureus, reared in intensive culture
Mol, K.; Byamungu, N.; Cuisset, B. et al

in Fish Physiology and Biochemistry (1994), 13

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See detailSynthesis, purification and kinetic properties of fluorescein-labelled penicillins
Lakaye, Bernard ULg; Damblon, Christian ULg; Jamin, Marc et al

in Biochemical Journal (1994), 300

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See detailLa responsabilité délictuelle des communes
Lewalle, Paul ULg; Dressen, Cécile; Durviaux, Ann-Lawrence ULg

in Revue de Droit Communal (1994)

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See detailComparaison pratique de quelques méthodes d'analyse discriminante
Lazaar, N.; Palm, Rodolphe ULg

in Biométrie-Praximétrie (1994), 34

Dans cette étude, on compare les performances des trois méthodes d'analyse discriminante suivantes : analyse discriminante linéaire, analyse discriminante quadratique et analyse discriminante logistique ... [more ▼]

Dans cette étude, on compare les performances des trois méthodes d'analyse discriminante suivantes : analyse discriminante linéaire, analyse discriminante quadratique et analyse discriminante logistique. Les performances sont étudiées dans le cas de données réelles, en envisageant diverses transformations de variables destinées à modifier les conditions de normalité et d'égalité des variances entre populations. Aucune différence significative de performances entre méthodes n'a pu être mise en évidence au niveau de signification de 0,05. Par contre, les performances des trois méthodes diminuent quand les distributions des variables sont nettement non normales ou de variances très inégales. Différentes estimations des taux d'erreur ont également été comparées : resubstitutin, extraction-insertion et utilisation d'un échantillon-test. Les résultats ont montré que, par rapport à l'utilisation d'échantillons-tests, la méthode de resubstitution sous-estime le taux d'erreur. Cette sous-estimation est de l'ordre de 13 % du taux d'erreur réel. La méthode d'extraction-insertion donne par contre des résultats très semblables à la méthode utilisant un échantillon-test. [less ▲]

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See detailIsolation of the missing 5-end of the encoding region of the bovine leukemia virus cell receptor gene.
Ban, J.; Truong, A. T.; Horion, B. et al

in Archives of Virology (1994), 138(3-4),

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See detailReaction Dynamics of Collisionally activated Ammonia Cations.
Leyh, Bernard ULg; Hoxha, A.

in Chemical Physics (1994), 179

In the framework of a research on the collisional mechanisms involved in tandem mass spectrometry, the collisional activation processes of NH3+ with different target gases have been investigated. The ... [more ▼]

In the framework of a research on the collisional mechanisms involved in tandem mass spectrometry, the collisional activation processes of NH3+ with different target gases have been investigated. The experiments have been performed on an upgraded AEI-MS9 sector instrument equipped with two collision cells and include daughter ion spectra, ion kinetic energy spectra, determination of kinetic energy release distributions (KERD) and appearance energy measurements. We have shown that collisionally activated dissociation (CAD) of NH3+ into NH++[H,H] depends upon the internal energy of NH3+. This internal energy effect is also observed for the NH2++H channel, when Xe is the target gas; with He, such an effect could not be detected. The analysis of the KERD shows that production of NH2+ upon CAD takes place from the NH3+ ground electronic state by rotational predissociation; two components are observed, one which corresponds to a near-threshold process (mean kinetic energy release <T>=0.13 eV), and one characterized by <T>=0.56 ev corresponding to an excess energy of 2.1 eV above the dissociation threshold. NH+ fragments can be formed by two processes: the first one occurs at threshold and leads to NH+(X2Pi)+H2(X1Sigma+g); the second one is characterized by large KER values (up to 7 eV) and leads to either electronically excited NH+ or dissociation of H2. [less ▲]

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See detailRecension de l'ouvrage de Silvano Petrosino, "Jacques Derrida et la loi du possible"
Steinmetz, Rudy ULg

in Cahiers Internationaux de Symbolisme (1994)

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See detailAsthme et hyperréactivité bronchique non spécifique
Louis, Renaud ULg; Kayembe, J. M.; Radermecker, Maurice ULg

in Acta Clinica Belgica (1994), 49(3-4), 148-57

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes ... [more ▼]

Bronchial hyperresponsiveness is a hallmark of asthma although it can also be present, to a lesser extent, in other diseases. The level of bronchial responsiveness depends on immuno-inflammatory processes modifying the functional status of airway smooth muscle as well as the structure of the bronchial wall. The responsiveness toward a direct constricting pharmacological agent is poorly correlated to the one toward an indirect constricting agent or a physical stimulus which cause airway obstruction through a more complex mechanism. Transversal studies show a relationship between the severity of asthma and the level of methacholine airway responsiveness. Long term treatment with corticoids can reduce the bronchial hyperresponsiveness of asthmatics. [less ▲]

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See detailSymbolic Verification with Periodic Sets
Boigelot, Bernard ULg; Wolper, Pierre ULg

in Lecture Notes in Computer Science (1994), 818

Symbolic approaches attack the state explosion problem by introducing implicit representations that allow the simultaneous manipulation of large sets of states. The most commonly used representation in ... [more ▼]

Symbolic approaches attack the state explosion problem by introducing implicit representations that allow the simultaneous manipulation of large sets of states. The most commonly used representation in this context is the Binary Decision Diagram (BDD). This paper takes the point of view that other structures than BDD's can be useful for representing sets of values, and that combining implicit and explicit representations can be fruitful. It introduces a representation of complex periodic sets of integer values, shows how this representation can be manipulated, and describes its application to the state-space exploration of protocols. Preliminary experimental results indicate that the method can dramatically reduce the resources required for state-space exploration. [less ▲]

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See detailSynthesis by sol-gel process and characterization of barium-titanate
LECLOUX, A. J.; KOCKLENBERG, Régine; MICHAUX, Bernard et al

in Annales de Chimie Science des Materiaux (1994), 19(2), 67-78

Barium titanate gels are prepared by sol-gel process from titanium isopropoxide and barium hydroxide in presence of methoxyethanol, methanol and water. These gels are dried under vacuum. The influence of ... [more ▼]

Barium titanate gels are prepared by sol-gel process from titanium isopropoxide and barium hydroxide in presence of methoxyethanol, methanol and water. These gels are dried under vacuum. The influence of the hydrolysis ratio, the temperature and the vacuum level during drying is discussed. [less ▲]

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See detailLes manifestations neurologiques de l'infection a Borrelia burgdorferi (maladie de Lyme).
PEPIN, Jean-Louis ULg; Bastings, Eric; Lenaerts, Marc ULg et al

in Revue Médicale de Liège (1994), 49(11), 603-10

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See detailPeritoneal endometriosis: two-dimensional and three-dimensional evaluation of typical and subtle lesions.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise

in Annals of the New York Academy of Sciences (1994), 734

Endometriosis most commonly affects the pelvic peritoneum close to the ovaries, including the uterosacral ligaments, the ovarian fossa peritoneum, and the perito- neum of the cul-de-sac. The increased ... [more ▼]

Endometriosis most commonly affects the pelvic peritoneum close to the ovaries, including the uterosacral ligaments, the ovarian fossa peritoneum, and the perito- neum of the cul-de-sac. The increased diagnosis of endometriosis at laparoscopy can be explained by the increased experience and ability of the surgeon to detect such subtle lesions. The greatest change has been in the case of “subtle” lesions, which increased from 15% in 1986 to 65% in 1988. The diagnosis of peritoneal endometriosis at the time of laparoscopy is often made by the observation of typically puckered black or bluish lesions. There are, in addition, numerous subtle appearances of peritoneal endometriosis. These lesions, frequently nonpigmented, were diagnosed as endometriosis following confirmation by biopsy by Jansen and Russell in 1986. [less ▲]

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See detailDerechef Ounamon, 2,13-14
Winand, Jean ULg

in Göttinger Miszellen (1994), 139

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See detailStatistical properties of daily returns : evidence from european stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza

in Journal of Business Finance and Accounting (1994), 21(2), 271-282

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See detailL’expérience pédagogique: «Rénovation de l’enseignement fondamental - Développement corporel des enfants de 21/2 ans à 12 ans».
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Informations pédagogiques (1994), 10

Delmelle (1992) a clairement défini la philosophie général de l'expérience pédagogique: "Compte tenu des besoins, des structures administratives en vigueur, des disponibilités matérielles et humaines et ... [more ▼]

Delmelle (1992) a clairement défini la philosophie général de l'expérience pédagogique: "Compte tenu des besoins, des structures administratives en vigueur, des disponibilités matérielles et humaines et des contraintes budgétaires, la commission a défini, de la manière suivante, la philosophie d'une rénovation possible à échéance immédiate. (a) Dans l'enseignement fondamental, tout enfant doit pratiquer l'activité physique à raison d'une séance quotidienne; il est parfaitement possible d'agir en sorte que les activités et les structures générales de l'école ne soient pas bouleversées. ..." ... [less ▲]

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See detailEfficacité de la radiothérapie pour le traitement des récidives en gynécologie oncologique
COUCKE, Philippe ULg; Sartorelli, B

in Revue Médicale de la Suisse Romande (1994), 114(9), 799-804

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See detailAbnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.
Van Cauter, E. V.; Polonsky, K. S.; Blackman, J. D. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 79(6), 1797-805

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep ... [more ▼]

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep, 28 h of continuous wakefulness, and 8 h of daytime sleep. Blood samples were collected at 20-min intervals to assay glucose, insulin, C-peptide, cortisol, and GH. Sleep was polygraphically monitored. Abnormal temporal profiles of glucose regulation were observed during wakefulness and sleep in obese subjects. During daytime hours, the normal profile of glucose tolerance was reversed, as an improvement, rather than a deterioration, was observed from morning to late evening. This reversal of the daytime pattern appeared to be caused by a dual defect in glucose regulation during the previous night. Indeed, during early sleep, GH secretion was markedly reduced, and the nocturnal rises of glucose and insulin secretion were dampened. During late sleep, obese subjects failed to suppress insulin secretion and plasma glucose, resulting in high morning levels. Comparisons of metabolic and hormonal patterns during nocturnal and daytime sleep suggest that the failure to suppress insulin secretion in late sleep may reflect a relative insensitivity of the beta-cell to acute inhibitory effects of cortisol in addition to insulin resistance. [less ▲]

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See detailLe Marquis et les castrats. Note sur un tabou sadien
Durand, Pascal ULg

in Art&Fact (1994), 13

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See detailRelationships between metabolic clearance rate of insulin and body mass index in a female population ranging from anorexia nervosa to severe obesity.
Castillo, M. J.; Scheen, André ULg; Jandrain, Bernard ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1994), 18(1), 47-53

Changes in the metabolic clearance rate of insulin (MCRI) have been described in several pathological conditions. Conflicting data suggest that they may be related to either body mass index (BMI) or body ... [more ▼]

Changes in the metabolic clearance rate of insulin (MCRI) have been described in several pathological conditions. Conflicting data suggest that they may be related to either body mass index (BMI) or body composition. This study aimed to investigate the relationship between the MCRI and BMI in an exclusively female population showing a wide range of BMI. For that purpose, hyperinsulinemic normoglycemic glucose clamps were performed in nine anorectic subjects (BMI: 14.5 +/- 0.8 kg/m2), 11 healthy volunteers (BMI: 20.3 +/- 0.5 kg/m2) and 12 obese patients (BMI: 33.0 +/- 0.9 kg/m2). To exclude any influence of the menstrual cycle on the MCRI, five healthy women underwent three tests at different days of the menstrual cycle: menstruation period, late follicular pre-ovulatory phase and luteal phase, in random order. The MCRI, which was quite reproducible in a given subject, was not significantly modified by the menstrual cycle. In the premenopausal female population studied, the mean (+/- s.e.m.) MCRI normalized for body weight (kg) were 35.4 +/- 3.4, 24.7 +/- 1.8 and 14.0 +/- 1.0 ml/kg/min (P < 0.01) for anorectic subjects, healthy volunteers and obese patients, respectively. These differences were maintained when the MCRI was normalized according to corporeal surface (m2) (1018 +/- 75, 859 +/- 67, 638 +/- 40 ml/m2/min, P < 0.01) or lean body mass (kg) (37.1 +/- 3.4, 32.6 +/- 2.7 and 24.1 +/- 0.5 ml/kgLBM/min, P < 0.01), but disappeared when MCRI was expressed per kg of ideal body weight (24.6 +/- 2.2, 24.6 +/- 2.1 and 22.4 +/- 1.4 ml/kgIBW/min, n.s.).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailComparaison de plusieurs types d'unités d'échantillonnage dans la perspective d'un inventaire forestier régional.
Lecomte, H.; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Forestry Chronicle (1994), 70(3), 304-310

This study has been conducted in order to define the guidelines of a permanent forest inventory methodology that could applied to heterogenous forests located in the southern part of Belgium. Different ... [more ▼]

This study has been conducted in order to define the guidelines of a permanent forest inventory methodology that could applied to heterogenous forests located in the southern part of Belgium. Different types of sampling units generally used in European national inventories have been compared: fixed area sampling units (based upon 3 concentric circles), non fixed-area sampling units (Bitterlich plots using basal area factor of 2 and 4) and sampling units based upon a minimum number of trees (including nearly 15 measurable trees). In true conditions of application 259 sampling points have been selected according to a systematic rectangular grid (1.000 m x 500 m). Taking into account different criteria such as precision, cost and ease of use, the fixed-area sampling unit looks like the most adequate among the four types investigated. [less ▲]

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See detailEtude du reservoir genetique de la legumineuse alimentaire Phaseolus lunatus L. par l'analyse electrophoretique d'isozymes.
Maquet, A.; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(3),

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See detailCompte-rendu de Lucie Antoniol, Lire Ryle aujourd'hui. Aux sources de la philosophie analytique
Leclercq, Bruno ULg

in Revue Philosophique de Louvain (1994), 92

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See detailThe functional proof of the diaphragm's specific type of motor innervation in Ongulae
Desmecht, Daniel ULg; Linden, Annick ULg; Leroy, Pascal ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailThe use of acarbose in the prevention and treatment of hypoglycaemia.
Lefebvre, Pierre ULg; Scheen, André ULg

in European Journal of Clinical Investigation (1994), 24 Suppl 3

This paper reviews the use of acarbose in the prevention and treatment of hypoglycaemia. In diet- or sulfonylurea-treated patients, acarbose may reduce the incidence of late postprandial hypoglycaemia. In ... [more ▼]

This paper reviews the use of acarbose in the prevention and treatment of hypoglycaemia. In diet- or sulfonylurea-treated patients, acarbose may reduce the incidence of late postprandial hypoglycaemia. In insulin-treated patients, acarbose treatment usually requires reduction of the insulin dose; one study has shown that 100 mg acarbose at night significantly reduces the incidence of mid-evening and nocturnal hypoglycaemia. Several studies have suggested acarbose to be a useful adjunct to the management of reactive hypoglycaemia in the non-diabetic patients. Long-term prospective studies are still needed to document this last indication of acarbose or other alpha-glycosidase inhibitors. [less ▲]

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See detailMBO en Aandeelhouder
Corhay, Albert ULg; Herst, Arthur; Tourani Rad, Alireza

in Bedrifskunde (1994), 4

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See detailT-CELLS SKIN LYMPHOMA IN 3 DOGS
Gilbert, S.; Clercx, Cécile ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1994), 138(8), 587-595

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See detailA Consistent next-to-leading order QCD calculation of hadronic diffractive scattering
Cudell, Jean-René ULg; Nguyen, Bao

in Nuclear Physics B (1994), 420

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See detailHématome extradural cervical spontané de la femme enceinte
Mahieu, X.; Kridelka, Frédéric ULg; Pintiaux, Axelle ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(1), 99-102

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The ... [more ▼]

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The patient underwent first a caesarean and thereafter a prompt spinal surgical decompression. Complete sensory-motor recovery occurred after 48 hours. Differential diagnosis of cord compression, etiology of bleeding, conditions of recovery after surgery are discussed. [less ▲]

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