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See detailUltrasonography of the Podotrochlear Apparatus in the Horse Using a Transcuneal Approach: Technique and Reference Images
Busoni, Valeria ULg; Denoix, Jean-Marie

in Veterinary Radiology & Ultrasound (2001), 42(6), 534-40

The purpose of this paper is to describe the technique for ultrasonographic examination of the podotrochlear apparatus in the horse using a transcuneal approach. In this study, ultrasound scans were ... [more ▼]

The purpose of this paper is to describe the technique for ultrasonographic examination of the podotrochlear apparatus in the horse using a transcuneal approach. In this study, ultrasound scans were performed in 3 normal cadaver limbs and 5 sound horses and images were compared to anatomic sections to establish the normal ultrasonographic anatomy of the podotrochlear apparatus. Detailed description of transverse and sagittal reference ultrasonographic images of this region is provided. This new imaging technique allows the assessment of the distal sesamoid bone flexor surface, the distal portion of the deep digital flexor tendon, the impar distal sesamoidean ligament, and the entheses of the distal phalanx. [less ▲]

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See detailIntervalle entre vêlage chez la vache Borgou au Benin
Adamou-N'Diaye, M.; Ogodija, O. J.; Gbangboche, A. B. et al

in Annales de Médecine Vétérinaire (2001), 145(2), 130-136

This retrospective study has been carry out in the Monastery bovine exploitation of Kokoubou (department of Borgou in Benin). Data were collected and analysed from individual cow records of 1967 to 1989 ... [more ▼]

This retrospective study has been carry out in the Monastery bovine exploitation of Kokoubou (department of Borgou in Benin). Data were collected and analysed from individual cow records of 1967 to 1989. It concerned 150 Borgou cows and 838 calving intervals. The following parameters have been determined: monthly frequency of calving and calving interval. Monthly frequencies of calving are not regrouped in rainy season. Calving intervals have decreased with lactation numbers, while the season presents no effect. [less ▲]

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See detailA recombinant beta-O-glucosidase from Caldocellum saccharolyticum to hydrolyse desulfo-glucosinolates
Wathelet, Jean-Paul ULg; Iori, R.; Leoni, O. et al

in Biotechnology Letters (2001), 23(6), 443-446

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum ... [more ▼]

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum saccharolyticum does not catalyse glucosinolate degradation but can hydrolyse desulfo-glucosinolates (thio-D-glucosidic substrates) to produce the corresponding pure nitriles, including valuable homochiral representatives. [less ▲]

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See detailCore-shell-corona micelles with a responsive shell
Gohy, Jean-François; Willet, Nicolas ULg; Varshney, Sunil et al

in Angewandte Chemie (International ed. in English) (2001), 40(17), 3214-3216

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See detailRadiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?
Zouhair, A; COUCKE, Philippe ULg; Jeanneret, W et al

in European Journal of Cancer (2001), 37

Abstract To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of ... [more ▼]

Abstract To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35±76 years). According to the International Union Against Cancer (UICC) 1997 classi®cation, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classi®cation was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20±331 months). In a median period of 12 months (range 5±139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy postoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5- and 10-year survival rates were 57% (95% con®dence interval (CI), 41±73%) and 38% (95% CI, 21± 55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41±73%) and 48% (95% CI, 32±64%), respectively. In patients treated with primary radiotherapy, 5- and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22±50%) and 18% (95% CI, 2±34%), respectively. In multivariate analyses, survival was signi®cantly in¯uenced by the N-classi®- cation, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squa- mous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no di erence in terms of survival between patients treated by surgery and those treated by primary radiotherapy salvage surgery, with 39% having organ preservation. [less ▲]

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See detailDoes F2 need a hard pomeron?
Cudell, Jean-René ULg; Soyez, G.

in Physics Letters B (2001), 516

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See detailSecret professionnel, confidentialité et juriste d'entreprise : la nouvelle donne
Thirion, Nicolas ULg; Benoit-Moury, Anne

in Journal des Tribunaux (2001)

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See detailFurther investigation of the supervisory attentional system in schizophrenia: Planning, inhibition, and rule abstraction
Marczewski, P.; Van der Linden, Martial ULg; Laroi, Frank ULg

in Cognitive Neuropsychiatry (2001), 6(3), 175-192

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational ... [more ▼]

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational level were compared. Three tasks (Tower of London, Hayling, and Brixton tests) were used to examine 3 executive processes (planning, inhibition, and rule detection). Schizophrenic patients performed significantly worse than normal controls on all 3 tasks. In addition, patients' performances on selected measures of the three tests were correlated, even when age and medication were partialled out. It is concluded that patients are impaired on all SAS functions. The possible role of a general impairment (processing speed or cognitive resources) is discussed [less ▲]

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See detailMeningeal inflammatory pseudotumour: a case report.
Gollogly, L.; Sadzot, Bernard ULg; Lejeune, Jean-Luc ULg et al

in Acta Neurologica Belgica (2001), 101(2), 116-20

We report the case of a meningeal inflammatory pseudotumour occurring in a 23-year-old male presenting with focal seizures and headaches. Brain imaging techniques showed a 3.5 cm left parietal meningeal ... [more ▼]

We report the case of a meningeal inflammatory pseudotumour occurring in a 23-year-old male presenting with focal seizures and headaches. Brain imaging techniques showed a 3.5 cm left parietal meningeal tumour. Histology of the surgical specimen showed a dense lymphoid infiltrate permeating the dura mater and leptomeninges, consisting of a predominant polyclonal B cell population as confirmed by immunophenotyping and genotyping. Cultures of serum, CSF, and surgical specimen were negative and there was no serological evidence of a systemic dysimmune disease. The postoperative course was complicated by an episode of brain oedema resolving under steroid therapy. The patient, free from all medication, is asymptomatic at 3 years of follow-up. We discuss previously published cases and the nosology of intracranial inflammatory pseudotumours. [less ▲]

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See detailHeat shock stimulation of a tilapia heat shock protein 70 promoter is mediated by a distal element
Molina, Alfredo; Di Martino, Emmanuel; Martial, Joseph ULg et al

in Biochemical Journal (2001), 356(Pt 2), 353-9

We reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell ... [more ▼]

We reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell culture and in microinjected zebrafish embryos. Here we present the first functional analysis of a fish HSP70 promoter, the tiHSP70 promoter. Using transient expression experiments in carp EPC (epithelioma papulosum cyprini) cells and in microinjected zebrafish embryos, we show that a distal heat shock response element (HSE1) at approx. -800 is predominantly responsible for the heat shock response of the tiHSP70 promoter. This element specifically binds an inducible transcription factor, most probably heat shock factor, and a constitutive factor. The constitutive complex is not observed with the non-functional, proximal HSE3 sequence, suggesting that both factors are required for the heat shock response mediated by HSE1. [less ▲]

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See detailBELL, regular 2001 issue
Delrez, Marc ULg

in Belgian Essays on Language and Literature (2001)

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See detailCommentaire
Richelle, Marc ULg

in Intellectica (2001), 32

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See detailQuelle évaluation externe des élèves pour quels socles de compétences ?
Bodin, A.; Delory, C.; Lafontaine, Dominique ULg et al

in Pédagogies, réformes et innovations dans l'enseignement (2001), 14

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See detailPSA kinetics after external beam radiotherapy alone or combined with an iridium brachytherapy boost to deliver 85 grays to prostatic adenocarcinoma.
Nickers, Philippe ULg; Coppens, Luc ULg; Beauduin, M. et al

in Strahlentherapie und Onkologie (2001), 177(2), 90-5

PURPOSE: Increasing the dose to prostatic adenocarcinoma in conformal external beam therapy (EBT) has resulted in increased levels of PSA normalization and increased percentage of biochemical disease-free ... [more ▼]

PURPOSE: Increasing the dose to prostatic adenocarcinoma in conformal external beam therapy (EBT) has resulted in increased levels of PSA normalization and increased percentage of biochemical disease-free survival rates. However technical problems due to prostate motion inside the pelvis or patients' set-up make difficult the realization of the EBT boost fields above 72 Gy. Brachytherapy which overcomes these problems was investigated to deliver the boost dose to achieve 85 Gy. PSA nadir which has been identified as the strongest independent predictor of any failure in many studies has been used as the end point for early evaluation of this work. PATIENTS AND METHODS: In a retrospective way we report on 163 patients' PSA kinetics after EBT alone to 68 Gy or EBT first and a brachytherapy boost up to 75 or 85 Gy. RESULTS: At 12 months follow-up, PSA nadirs percentage < or = 0.5 or < or = 1 ng/ml increased from 7.5 and 20.7% after 68 Gy EBT to 49.8 and 71.2% after a brachytherapy boost to deliver 85 Gy (p < 0.0001). In the Cox PH model analysis, the total dose remained the most important factor for predicting PSA normalization. CONCLUSIONS: These results are in accordance with the most recent results published after conformal EBT at the same 80 Gy level of dose. If confirmed on a higher number of patients they could place brachytherapy among the most accurate methods of boosting in the radiation treatment of prostatic carcinoma. [less ▲]

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See detailStratification of single-vessel coronary stenosis by ischemic threshold at the onset of wall motion abnormality during continuous monitoring of left ventricular function by semisupine exercise echocardiography.
Garot, J.; Hoffer, E. P.; Monin, J. L. et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2001), 14(8), 798-805

We studied the relation between the ischemic threshold at the onset of wall motion abnormality on exercise echocardiography (EE) and the severity of coronary stenosis in patients with 1-vessel coronary ... [more ▼]

We studied the relation between the ischemic threshold at the onset of wall motion abnormality on exercise echocardiography (EE) and the severity of coronary stenosis in patients with 1-vessel coronary artery disease (CAD). We screened 216 consecutive patients who underwent coronary angiography and EE for suspected CAD. Ninety-five (74 men; age, 56 +/- 12 years) satisfied the study criteria, that is, the presence of 1-vessel disease or no evidence of CAD on angiography and a normal baseline echocardiogram. Eighty-seven patients had 1-vessel CAD on angiography, and exercise-induced wall motion abnormality occurred in 73 (77%). Optimal cutoff values of percent diameter stenosis and minimal lumen diameter for predicting a positive EE were 61% (sensitivity and specificity of 76%) and 1.12 mm (sensitivity and specificity of 74%). Among patients with positive EE, heart rate-blood pressure product at ischemic threshold was correlated with quantitative coronary stenosis (r = -0.72, P <.001). The ischemic threshold from continuous monitoring of left ventricular function during semisupine EE is correlated with the severity of coronary stenosis among patients with 1-vessel disease and a normal resting echocardiogram. [less ▲]

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See detailProper orthogonal decomposition for model updating of non-linear mechanical systems
Lenaerts, V.; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in Mechanical Systems & Signal Processing (2001), 15(1)

Proper orthogonal decomposition (POD), also known as Karhunen}Loeve (K}L) decomposition, is emerging as a useful experimental tool in dynamics and vibrations. The POD is a means of extracting spatial ... [more ▼]

Proper orthogonal decomposition (POD), also known as Karhunen}Loeve (K}L) decomposition, is emerging as a useful experimental tool in dynamics and vibrations. The POD is a means of extracting spatial information from a set of time-series data available on a domain. The use of (K}L) transform is of great help in non-linear settings where traditional linear techniques such as modal-testing and power-spectrum analyses cannot be applied. These decomposition can be used as an orthogonal basis for e$cient representation of the ensemble. The POM have been interpreted mainly as empirical system modes and the application of POD to measured displacements of a discrete structure with a known mass matrix leads to an estimation of the normal modes. We investigate the use of the proper orthogonal modes of displacements for the identi"cation of parameters of non-linear dynamical structures with an optimisation procedure based on the di!erence between the experimental and simulated POM. A numerical example of a beam with a local non-linear component will illustrate the method. (C) 2001 Academic Press [less ▲]

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See detailAcquisition of a novel vocabulary in an amnesic patient
Van der Linden, Martial ULg; Cornil, Valérie; Meulemans, Thierry ULg et al

in Neurocase : Case Studies in Neuropsychology, Neuropsychiatry & Behavioural Neurology (2001), 7(4), 283-293

This study explored the ability of a severe amnesic patient (AC) to acquire new vocabulary words. We compared AC's knowledge of words entered into the French lexicon during three different periods: before ... [more ▼]

This study explored the ability of a severe amnesic patient (AC) to acquire new vocabulary words. We compared AC's knowledge of words entered into the French lexicon during three different periods: before 1920, between 1965 and 1985, and after 1986 (i.e. after the onset of his amnesia). AC's knowledge was assessed by asking him to give, for each word, its definition (word-definition task), the general domain Io which the word belonged ('domain' task), and to generate a sentence containing the word (sentence-generation task). Finally, we administered a recognition task in which AC had to select, for each word, its correct definition amongst four definitions. For all of these tasks, the results showed that AG's performance was similar to that of four control subjects matched for age, education, and profession. In particular, there was no difference with regard to AC's knowledge of words entered into the language after the onset of his amnesia. Therefore, these results indicate that, despite his profound amnesia, AC was able to learn normally new vocabulary words. More generally, they confirm that, at least is some cases, semantic learning can be spared in amnesia. [less ▲]

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See detailRespiratory chain network in mitochondria of Candida parapsilosis: ADP/O appraisal of the multiple electron pathways.
Milani, G.; Jarmuszkiewicz, W.; Sluse-Goffart, C. et al

in FEBS Letters (2001), 508

In this study we demonstrated that mitochondria of Candida parapsilosis contain a constitutive ubiquinol alternative oxidase (AOX) in addition to a classical respiratory chain (CRC) and a parallel ... [more ▼]

In this study we demonstrated that mitochondria of Candida parapsilosis contain a constitutive ubiquinol alternative oxidase (AOX) in addition to a classical respiratory chain (CRC) and a parallel respiratory chain (PAR) both terminating by two different cytochrome c oxidases. The C. parapsilosis AOX is characterized by a fungi-type regulation by GMP (as a stimulator) and linoleic acid (as an inhibitor). Inhibitor screening of the respiratory network by the ADP/O ratio and state 3 respiration determinations showed that (i) oxygen can be reduced by the three terminal oxidases through four paths implying one bypass between CRC and PAR and (ii) the sum of CRC, AOX and PAR capacities is higher than the overall respiration (no additivity) and that their engagement could be progressive according to the redox state of ubiquinone, i.e. first cytochrome pathway, then AOX and finally PAR. [less ▲]

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See detailAdding olanzapine to venlafaxine in treatment-refractory non-psychotic chronic depression
PITCHOT, William ULg; ANSSEAU, Marc ULg

in American Journal of Psychiatry (The) (2001)

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See detailEffects of allelochemicals from first (Brassicaceae) and second (Myzus persicae and Brevicoryne brassicae) trophic levels on Adalia bipunctata
Francis, Frédéric ULg; Lognay, Georges ULg; Wathelet, Jean-Paul ULg et al

in Journal of Chemical Ecology (2001), 27(2), 243-256

Three Brassicaceae species, Brassica napus (low glucosinolate content), Brassica nigra (including sinigrin), and Sinapis alba (including sinalbin) were used as host plants for two aphid species: the ... [more ▼]

Three Brassicaceae species, Brassica napus (low glucosinolate content), Brassica nigra (including sinigrin), and Sinapis alba (including sinalbin) were used as host plants for two aphid species: the generalist Myzus persicae and the specialist Brevicoryne brassicae. Each combination of aphid species and prey host plant was used to Feed the polyphagous ladybird beetle, Adalia bipunctata. Experiments with Brassicaceae species including different amounts and kinds of glucosinolates (GLS) showed increased ladybird larval mortality at higher GLS concentrations. When reared on plants with higher GLS concentrations, the specialist aphid, B. brassicae, was found to be more toxic than M. persicae. Identification of GLS and related degradation products, mainly isothiocyanates (ITC), was investigated in the first two trophic levels, plant and aphid species, by high-performance liquid chromatography and gas chromatography-mass spectrometry, respectively. While only GLS were detected in M. persicae on each Brassicaceae species, high amounts of ITC were identified in B. brassicae samples (allyl-ITC and benzyl-ITC from B. nigra and S. alba, respectively) from all host plants. Biological effects of allelochemicals from plants on predators through aphid prey are discussed in relation to aphid species to emphasize the role of the crop plant in integrated pest management in terms of biological control efficacy. [less ▲]

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See detailStand der osteoporose-Therapie. Ein Medizinischer Skandal
Reginster, Jean-Yves ULg

in MMW Fortschritte der Medizin (2001), 143(14), 43

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See detailSpécificités de la fonction cardiorespiratoire de l'âne (Equus asinus)
Delvaux, Véronique ULg; Kirschvink, Nathalie; Amory, Hélène ULg et al

in Pratique Vétérinaire Equine (2001), 33(129), 21-28

A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For ... [more ▼]

A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For particular tests (haematology, measurement of arterial blond gases, electrocardiogram with phonocardiogram and thoracic radiographs, cardias echography), no major differences were found. However, the mechanical ventilation parameters differed from those for horses and moere similar to Chose for food-producing animais (carde): a higher resistance, a lower compliance and a higher maximum pleural pressure variation moere found. The "respiratory strategy" adopted by certain donkeys is different from that of horses: there are two to three phases of inspiration with a nil airflow between each phase. Expiration is the same as for horses. The conformation of the pharynx and larynx is slightly different to that of horses making it more difficult to pass an endoscope through this area. The lower respiratory tract is sensitive and it is necessary to apply a local anaesthetic (xylocaine) for this examination. The différential leukocyte count from tracheal lavage includes a number of epithelial cells, and a higher percentage of eosinophils and neutrophile for donkeys compared to horses. These similarities and différences between donkeys and horses should be taken into account when performing ancillary tests [less ▲]

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See detailReduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: another indication of abnormal sensory processing?
Ambrosini, A.; De Pasqua, Victor ULg; Afra, J. et al

in Neuroscience Letters (2001), 306(1-2), 132-4

Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The ... [more ▼]

Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The amplitude of the P50 response to the second of two homologous stimuli was significantly less reduced in migraineurs than in healthy volunteers. This lack of auditory sensory gating may be due to a hypofunction of monoaminergic subcortico-cortical pathways, which is also supposed to cause the interictal deficit of cortical habituation to repetitive stimuli. [less ▲]

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See detailLa réception de l’art japonais en Belgique
Bawin, Julie ULg

in Art&Fact (2001)

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See detailLes techniques d'empreinte en implantologie
Van Heusden, Alain ULg

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (2001), 56(3), 189-203

The implant-borne prostheses have become an integral part of the oral rehabilitation procedures. The aim of this article is to describe the most current impression techniques for oral implant prosthetics ... [more ▼]

The implant-borne prostheses have become an integral part of the oral rehabilitation procedures. The aim of this article is to describe the most current impression techniques for oral implant prosthetics used at the University of Liege, Belgium. Impression protocols adapted to various prosthetic procedures are described step-by-step through several clinical cases. Emphasis is put on the means necessary for achieving a precise adaptation and a passive fit of the final prosthetic suprastructure. [less ▲]

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See detailOnychomycosis and Other Superficial Fungal Infections of the Foot in the Elderly: A Pan-European Survey
Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 202(3), 220-4

BACKGROUND: The escalating ageing population in the western world has led to an increased incidence of superficial fungal infections. The most common infections include onychomycosis, tinea pedis and ... [more ▼]

BACKGROUND: The escalating ageing population in the western world has led to an increased incidence of superficial fungal infections. The most common infections include onychomycosis, tinea pedis and tinea cruris. With the increasing life expectancy, the prevalence of onychomycosis and other superficial fungal infections is likely to increase further without adequate prevention and treatment. Objective: To study the prevalence of foot mycoses in Europe. METHOD: The Achilles project represents a survey of 90,085 subjects from 16 European countries. RESULTS: Approximately half of the total screened population had evidence of fungal foot infection, with tinea pedis and onychomycosis affecting one quarter of these individuals. Advancing age showed an unfavourable effect on the prevalence of these infections. CONCLUSION: As the number of aged people in developed countries continues to increase, skin diseases will constitute a greater pharmaco-economic concern of worldwide healthcare. Better recognition by clinicians and patients of mycotic foot disease will help prevent direct morbidity and further complications. [less ▲]

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See detailConsumer Evaluations of Brand Extensions: Differences between Goods and Services
Van Riel, Allard ULg; Lemmink, Jos; Ouwersloot, Hans

in Journal of Service Research (2001), 3(3), 220-231

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See detailImproved Quantification of Angiogenesis in the Rat Aortic Ring Assay
Blacher, Silvia ULg; Devy, L.; Burbridge, M. F. et al

in Angiogenesis (2001), 4(2), 133-42

In vitro angiogenesis assays are essential for the identification of potential angiogenic agents and screening for pharmacological inhibitors. Among these assays, the rat aortic ring model developed by ... [more ▼]

In vitro angiogenesis assays are essential for the identification of potential angiogenic agents and screening for pharmacological inhibitors. Among these assays, the rat aortic ring model developed by Nicosia bridges the gap between in vivo and in vitro models. The quantification of angiogenesis on this system must be applicable to characterise vascular networks of various states of complexity. We present here an improved computer-assisted image analysis which allows: (1) the determination of the aortic ring area and its factor shape; (2) the number of microvessels, the total number of branchings, the maximal microvessel length and the microvessel distribution; (3) the total number of isolated fibroblast-like cells and their distribution. We show that this method is suitable to quantify spontaneous angiogenesis as well as to analyse a complex microvascular network induced by various concentrations of vascular endothelial growth factor (VEGF). In addition, by evaluating a new parameter, the fibroblast-like cell distribution, our results show that: (1) during spontaneous angiogenic response, maximal fibroblast-like cell migration delimits microvascular outgrowth; and (2) the known angiogenic inhibitor Batimastat prevents endothelial cell sprouting without completely blocking fibroblast-like cell migration. Finally, this new method of quantification is of great interest to better understand angiogenesis and to test pro- or anti-angiogenic agents. [less ▲]

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See detailModelling of friction and wear for designing cryogenic valves
Bozet, Jean-Luc ULg

in Tribology International (2001), 34(4), 207-215

From a tribological point of view, the selection of materials for seals for valves of cryogenic rocket engines is a critical issue for the designer. Due to the lack of comprehensive information on this ... [more ▼]

From a tribological point of view, the selection of materials for seals for valves of cryogenic rocket engines is a critical issue for the designer. Due to the lack of comprehensive information on this topic. data have been obtained in the framework of research programmes. In the first step, two polymers potentially usable for sealing cryogenic fluids were identified, They were submitted to general test conditions to gain some fundamental understanding of their tribological behaviour when immersed in a cryogenic fluid. This fundamental understanding proved to be helpful for an efficient technical approach. This approach with the test conditions as close as possible to those met in real valves has been used in the second step. In order to obtain the best information with the minimum number of tests, the statistical method of Doehlert has been adopted. The use of such a method led to the construction of surface response for modelling friction and wear. These surfaces and their associated equation are directly and easily usable by the designer, This way of treating technical tribological problem is illustrated by an example. (C) 2001 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailExploring Consumer Evaluations of e-Services: A Portal Site
Van Riel, Allard ULg; Liljander, Veronica

in International Journal of Service Industry Management (2001), 12(4), 359-377

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See detailLes régimes d’épargne protéique dans le traitement de l’obésité
PAQUOT, Nicolas ULg

in Nutrition Clinique et Metabolisme (2001), 15

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See detailDroits de la défense et informations relatives à la situation judiciaire du prévenu figurant indûment au dossier
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailA simple tool to identify asian women at increased risk of osteoporosis.
Koh, L K; Sedrine, W B; Torralba, T P et al

in Osteoporosis International (2001), 12(8), 699-705

Patients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available ... [more ▼]

Patients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available in some communities, because of cost and lack of equipment. Simple questionnaires have been designed to help target high-risk women for BMD measurements, thereby avoiding the cost of measuring women at low risk. However, such tools have previously focused on evaluation of non-Asian women. We collected information about numerous risk factors from postmenopausal Asian women in eight countries in Asia using questionnaires, and evaluated the ability of these risk factors to identify women with osteoporosis as defined by femoral neck BMD T-scores < or =-2.5. Multiple variable regression analysis and item reduction yielded a final tool based on only age and body weight. This risk index had a sensitivity of 91% and specificity of 45%, with an area under the curve of 0.79. Previously published risk indices based on larger numbers of variables performed similarly well in this Asian population. Large differences in risk were identified using our index to create three categories: 61% of the high-risk women had osteoporosis, compared with only 15% and 3% of the intermediate- and low-risk women, respectively. The low-risk group represented 40% of all women, for whom BMD measurements are probably not needed unless important risk factors, such as prior nonviolent fracture or corticosteroid use, are present. An existing population-based sample of postmenopausal Japanese women was used to validate our index. In this sample of Japanese women the sensitivity was 98% and specificity was 29%; the low-risk category, for whom BMD is probably unnecessary, represented 25% of all women. We conclude that our index performed well for classifying the risk of osteoporosis among postmenopausal Asian women and applying it would result in more prudent use of BMD technology. [less ▲]

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See detailLarge-Scale Phenotypic Analysis Reveals Identical Contributions To Cell Functions Of Known And Unknown Yeast Genes
Bianchi, Mm.; Ngo, S.; Vandenbol, Micheline ULg et al

in Yeast (2001), 18(15),

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See detailLe pilotage des systèmes d'enseignement
de Landsheere, Gilbert ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (5-6), 115-120

Un peu moins de trois ans après le congrès 'La Wallonie au futur. Le défi de l'éducation' (Namur, octobre 1991), Gilbert de Landsheere reprend la parole lors de l'introduction d'une conférence-consensus ... [more ▼]

Un peu moins de trois ans après le congrès 'La Wallonie au futur. Le défi de l'éducation' (Namur, octobre 1991), Gilbert de Landsheere reprend la parole lors de l'introduction d'une conférence-consensus (Namur, mars 1994) sur le thème 'Où en est et où va le système éducatif en Wallonie? Comment le savoir ?'. Il y est plus inquiet et en colère que jamais... et il le fait savoir ! Il poursuit la réflexion qu'il avait livrée dans deux des textes que nous publions également dans ces Cahiers ('L'avenir de l'enseignement' et 'Propositions relatives à l'enseignement'). Il expose aussi la substance de l'ouvrage qu'il fera publié chez De Boeck la même année. [less ▲]

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See detailPractical Aspects Of Computational Chemistry Calculations Through Pc Networks: The Ramses-Beowulf Implementation
Beuve-Mery, D.; Rahman, M.; Ducarme, P. et al

in Journal of Computational Chemistry (2001), 22(2), 172-7

We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our ... [more ▼]

We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our experience and discuss our choices. The architecture is composed of Pentium processors connected by a 100 Mbits/s Ethernet network. Because RAMSES are built of independent computers, the system is easily maintained, and can be modified by adding or removing machines. Two programs, which are dedicated to molecular modeling and were previously developed on single machines (OSIRIS and IMPALA), have been adapted. IMPALA models peptide and protein interaction with membranes, OSIRIS simulates an ab initio folding of globular proteins. After parallelization, each program consists of two parts: one is the human/RAMSES interface, and the second is the simulation per se. The parallel architecture is transparent for the users. Tests of the IMPALA and OSIRIS efficiencies are shown and discussed. [less ▲]

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See detailFellhanera gyrophorica, a new European species with conspicuous pycnidia
Sérusiaux, Emmanuël ULg; Coppins, Brian J.; Diederich, Paul et al

in Lichenologist (2001), 33

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See detailRevising the judicial architecture of the European Union
Munoz, Rodolphe ULg

in Yearbook of European law (2001), 19

L'article reprend l'ensemble des propositions faites à l'époque par la doctrine concernant les modifications à apporter à l'architecture juridique de l'Union. Chacun des articles du contentieux est ... [more ▼]

L'article reprend l'ensemble des propositions faites à l'époque par la doctrine concernant les modifications à apporter à l'architecture juridique de l'Union. Chacun des articles du contentieux est analysée et des propositions concrètes de mofdifications sont faites. [less ▲]

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See detailCushing's disease in childhood: presentation, investigation, treatment and long-term outcome.
Savage, M. O.; Lienhardt, A.; LEBRETHON, Marie-Christine ULg et al

in Hormone research (2001), 55 Suppl 1

Seventeen patients with Cushing's disease (CD) were treated from 1978 to 2000. There were 11 males and 6 females aged 6.8-18.8 years (mean age 13.0 +/- 5.9 years). Presenting features were: weight gain ... [more ▼]

Seventeen patients with Cushing's disease (CD) were treated from 1978 to 2000. There were 11 males and 6 females aged 6.8-18.8 years (mean age 13.0 +/- 5.9 years). Presenting features were: weight gain (100%); growth failure (71%); hirsutism (53%); striae (53%); hypertension (47%). Mean age of patients with striae was 15.2 +/- 2.3 years, without striae 10.3 +/- 3.3 years. Median height SDS was -1.81 (range -0.28 to -4.17), 53% having height SDS < -1.8. The height velocity in 6 subjects was subnormal (0.9-3.8 cm/year). Median BMI SDS was 2.29 (range 1.72-5.06). Cushing's disease was confirmed by detectable serum ACTH, median 28 ng/l (range 12-99, NR <10-50) (n = 15); loss of cortisol circadian rhythm values at midnight ranging from 216 to 1,080 nmol/l (NR <50) (n = 15); lack of cortisol suppression (NV < 50 nmol/l) during low-dose dexamethasone suppression test (LDDST) (0.5 mg 6-hourly x 8) (n = 14); and >50% suppression of cortisol compared with the basal value during high-dose dexamethasone suppression test (HDDST) (2 mg 6-hourly x 8) (n = 14). A CRH test (1 microg/kg i.v.) showed an increase of cortisol from 12 to 217% (median 73.5%) (n = 16). Pituitary imaging (CT/MRI) showed an image consistent with microadenoma in 6/17 patients, but there was concordance between pituitary imaging and surgical findings in 1/11 patients (9%). Inferior petrosal sinus sampling (IPSS) for ACTH after CRH was performed in 11 subjects (age 10.7-18.8 years). Central to peripheral ACTH ratios were >2 (2.5-157.2) in 10/11 patients. The inter-petrosal sinus ACTH gradient was >1.4 in 10 patients (2.1-20.8), indicating lateralization of ACTH secretion. In 10 patients (91%), the side of the tumour on IPSS was predictive of findings at surgery. Therapy consisted of transsphenoidal microadenomectomy (TSS) in 16 patients and bilateral adrenalectomy (1978) in 1. Following TSS alone, 7 patients were cured (cortisol <50 nmol/l) and 2 were in remission (cortisol <300 nmol/l), i.e. 56%. Seven had persisting hypercortisolaemia and underwent pituitary irradiation (4,500 cGy). Therapeutic outcome for a median of 8 years (0.5-24 years) resulted in cure of CD in 14/17 patients (82%) and remission in 1. Linear growth after TSS +/- pituitary irradiation in 10 subjects showed no short-term catch-up growth, with peak growth hormone (GH) 0.5-20.9 mU/l to insulin tolerance test (ITT)/glucagon. Eight patients were treated with human growth hormone (hGH) (14 U/m(2)/week) combined in 3 with GnRH analogue. The mean final (n = 6) or latest (n = 4) height SDS was -1.36. The difference between final/latest height SDS and target height SDS was 0.93 +/- 1.13, i.e. less (p = 0.005) than the difference between height SDS and target height SDS at presentation, i.e. 1.72 +/- 1.26, indicating long-term catch-up growth. [less ▲]

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See detailRecommandations de l’association d’épidémiologie et de santé animale concernant la lutte contre la rhinotrachéite infectieuse bovine (IBR) en Belgique
Limbourg, B.; Kerkhofs, P.; Massard, C. et al

in Annales de Médecine Vétérinaire (2001), 147

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See detailActualités thérapeutiques de la polyarthrite rhumatoïde
Ribbens, Clio ULg; Andre, Béatrice ULg; Kaye, O. et al

in Revue de la Médecine Générale [=RMG] (2001), 186

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See detailEffet of dietary fat levels on growth, feed efficiency and biochemical compositions of Eurasian perch Perca fluviatilis
Xu; Fontaine, P.; Mélard, Charles ULg et al

in Aquaculture International (2001), 9

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See detailIrradiation du petit bassin et fonction ano-rectale.
Gervaz, P; COUCKE, Philippe ULg; Gillet, M

in Gastroentérologie Clinique et Biologique (2001), 25

Le traitement adjuvant des cancers du rectum a pour buts de stériliser la maladie résiduelle infra-clinique et d’améliorer le contrôle local. Depuis plus de 20 ans, des milliers de malades ont été inclus ... [more ▼]

Le traitement adjuvant des cancers du rectum a pour buts de stériliser la maladie résiduelle infra-clinique et d’améliorer le contrôle local. Depuis plus de 20 ans, des milliers de malades ont été inclus dans des études randomisées, visant d’abord à mettre en évidence un gain de survie et une réduction des récidives loco-régionales, en relation avec la radiothérapie pré- ou postopératoire, combinée ou non à la chimiothérapie. Les conséquences en termes de qualité de vie de ces traitements ont pourtant été peu étudiées, et la tolérance fonctionnelle du néo-rectum et de l’appareil sphinctérien à la radiothérapie restent mal connues [1]. Les difficultés liées à l’étude des effets de l’irradiation sur les tissus normaux, ainsi que la variabilité inter-individuelle de la réponse à la radiothérapie, s’ajoutent et rendent le sujet plus complexe encore. Les radiothérapeutes adaptent leur technique afin de réduire autant que possible la dose administrée aux tissus normaux avoisinant la tumeur. Dans le cas de l’irradiation du petit bassin, c’est l’intestin grêle qui a longtemps été considéré comme la structure à risque de complications, alors que l’atteinte du sphincter anal était rarement mentionnée [2]. Malgré les répercussions importantes de la dysfonction ano-rectale sur la qualité de vie des malades, l’atteinte du sphincter anal par la radiothérapie est restée un aspect négligé du traitement adjuvant des cancers du petit bassin [3]. Cet article a pour but, à travers une revue de la littérature, de mettre en évidence les effets qualitatifs et quantitatifs de la radiothérapie sur la fonction du sphincter anal, ainsi que de proposer une modification de la technique actuelle d’irradiation des cancers du bas rectum. [less ▲]

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See detailAn improved weighting method with multibounds formulation and convex programming for multicriteria structural optimization
Zhang, W. H.; Domaszewski, M.; Fleury, Claude ULg

in International Journal for Numerical Methods in Engineering (2001), 52(9), 889-902

This paper presents an improved weighting method for multicriteria structural optimization. By introducing artificial design variables, here called as multibounds formulation (MBF), we demonstrate ... [more ▼]

This paper presents an improved weighting method for multicriteria structural optimization. By introducing artificial design variables, here called as multibounds formulation (MBF), we demonstrate mathematically that the weighting combination of criteria can be transformed into a simplified problem with a linear objective function. This is a unified formulation for one criterion and multicriteria problems. Due to the uncoupling of involved criteria after the transformation, the extension and the adaptation of monotonic approximation-based convex programming methods such as the convex linearization (CONLIN) or the method of moving asymptotes (MMA)are made possible to solve multicriteria problems as efficiently as for one criterion problems. In this work, a multicriteria optimization tool is developed by integrating the multibounds formulation with the CONLIN optimizer and the ABAQUS finite element analysis system. Some numerical examples are taken into account to show the efficiency of this approach. [less ▲]

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See detailEndothelin in the equine hypoxic pulmonary vasoconstrictive response to acute hypoxia
Benamou, A. E.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal (2001), 33(4), 345-353

Elevated concentrations of endothelin (ET), a potent endothelium-derived vasoactive peptide, have been reported in a number of pathophysiological conditions associated with pulmonary hypertension, both in ... [more ▼]

Elevated concentrations of endothelin (ET), a potent endothelium-derived vasoactive peptide, have been reported in a number of pathophysiological conditions associated with pulmonary hypertension, both in the horse and other species. We have previously shown, both in vitro and in vivo, that the pulmonary and systemic vascular response to exogenous ET is mediated predominantly via ET(A) receptors. Our hypothesis in the present study was that ET is involved in the equine hypoxic pulmonary vasoconstrictive response to acute hypoxia. In this study, we investigated the effects of a selective ET(A) receptor antagonist on hypoxic pulmonary hypertension in the mature horse. Horses were exposed to a 10 min period of hypoxia (F(I)O2 approximately 0.11) on 2 occasions, with and without pretreatment with the selective ET(A) receptor antagonist TBC11251 (10 mg/kg bwt i.v.). Hypoxia increased mean pulmonary artery pressure (PAP) from 18.3+/-0.9 (mean +/- s.e. normoxia) to 28.0+/-0.8 mmHg (hypoxia) in the session without ET(A) receptor antagonism. Carotid arterial pressure (CAP) also increased progressively throughout the period of hypoxic challenge and at the end was 153+/-5 mmHg (hypoxia) compared to during normoxia (140+/-5 mmHg). There was no significant overall effect of ET(A) receptor antagonism on the haemodynamic or ventilatory responses to acute hypoxia. However, between 5 and 10 min of hypoxia there was a trend for the mean PAP to diverge in the 2 treatments, which just failed to reach significance at 10 min of hypoxia (P = 0.053). In conclusion, this study describes the haemodynamic and ventilatory changes in response to a period of acute hypoxia in the adult horse. The results do not support a role for ET as a mediator of acute HPV in the horse, but suggest that it may be involved as a modulator or in the slower (>10 min) phase of HPV. [less ▲]

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See detailChemical Nature And Persistence Of The Oviposition Deterring Pheromone In The Tracks Of The Larvae Of The Two Spot Ladybird, Adalia Bipunctata (Coleoptera : Coccinellidae)
Hemptinne, Jl.; Lognay, Georges ULg; Doumbia, M. et al

in Chemoecology (2001), 11(1), 43-47

Aphidophagous ladybirds are reluctant to oviposit in patches of prey where conspecific larvae are present. This is adaptive as larval cannibalism is a major threat to egg survival. Ladybirds avoid laying ... [more ▼]

Aphidophagous ladybirds are reluctant to oviposit in patches of prey where conspecific larvae are present. This is adaptive as larval cannibalism is a major threat to egg survival. Ladybirds avoid laying eggs in such patches by responding to a species specific oviposition deterring pheromone present in the tracks of larvae. This study revealed that the oviposition deterring pheromone consists of a mixture of alkanes of which n-pentacosane is the major component (15.1%). These alkanes are likely to spread easily on the hydrophobic cuticle of plants and so leave a large signal. In addition, they are not quickly oxidized and therefore provide a long lasting signal. The latter was confirmed by the observation that 10 day old tracks still deterred oviposition. [less ▲]

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See detailPharma-clinics. Le medicament du mois. Le celecoxib (Celebrex).
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(1), 53-5

Celecoxib (Celebrex, Pharmacia) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as nonsteroidal anti-inflammatory drug (NSAID). Its current indications are ... [more ▼]

Celecoxib (Celebrex, Pharmacia) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as nonsteroidal anti-inflammatory drug (NSAID). Its current indications are osteoarthritis and rheumatoid arthritis. The usual recommended daily dosage of celecoxib is 200 mg (in one or two intakes per day), to be increased up to 400 mg (two intakes per day) if necessary. Its clinical efficacy seems to be similar to that of other NSAIDs. However, its safety profile, especially gastro-intestinal tolerance and perhaps renal safety, is much better because of the COX-2 selectivity. [less ▲]

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See detailL'assurance de qualité et le médecin de famille.
Roland, Michel; Prevost, Marianne; Jamoulle, Marc ULg

in Archives of Public Health (2001), 59

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See detailThe organotypic culture of HPV-transformed keratinocytes: an effective in vitro model for the development of new immunotherapeutic approaches for mucosal (pre)neoplastic lesions.
Delvenne, Philippe ULg; Hubert, Pascale ULg; Jacobs, Nathalie ULg et al

in Vaccine (2001), 19(17-19), 2557-64

The purpose of this study is to develop a reliable in vitro human model to test new immunotherapeutic approaches for squamous cell carcinoma that develop on mucosal surfaces. The organotypic (raft ... [more ▼]

The purpose of this study is to develop a reliable in vitro human model to test new immunotherapeutic approaches for squamous cell carcinoma that develop on mucosal surfaces. The organotypic (raft) culture permits cells to proliferate and differentiate at an air-liquid interface on a dermal equivalent support. Normal keratinocytes stratify and fully differentiate in a manner similar to the normal squamous epithelial tissues, while human papillomavirus-immortalized and established squamous carcinoma cell lines exhibit dysplastic morphologies similar to (pre)neoplastic lesions seen in vivo. We have demonstrated the ability of these organotypic cultures to be manipulated by altering the epithelial stratification with cytokines (interferon-gamma and tumor necrosis factor-alpha) and by integrating activated lymphocytes or dendritic cells into the in vitro formed epithelial sheet. This model may provide a useful tool to investigate the factors contributing to the presence and function of immunocompetent cells within a neoplastic epithelium that develops on a mucosal surface. [less ▲]

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See detailLe polygraphe et les exigences de la preuve en matière pénale
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailScytalidium Dimidiatum Melanonychia and Scaly Plantar Skin in Four Patients from the Maghreb: Imported Disease or Outbreak in a Belgian Mosque?
Arrese, J. E.; Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 202(2), 183-5

Scytalidium dimidiatum is a geophilic dematiaceous, non-dermatophyte mould that can become a pathogen for plants and humans particularly in tropical and subtropical regions. We report 4 cases of S ... [more ▼]

Scytalidium dimidiatum is a geophilic dematiaceous, non-dermatophyte mould that can become a pathogen for plants and humans particularly in tropical and subtropical regions. We report 4 cases of S. dimidiatum onychomycosis presenting clinically as thickened and dark toenails. The skin of the soles was scaly. The time and location of the contaminations were uncertain. Indeed, the patients were ancient immigrants from the Maghreb to Belgium. They were also regularly travelling to their countries of origin. They were also often barefoot in the same Belgian mosque. The disease was unresponsive to current oral antifungal treatments. [less ▲]

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See detailInfluence of moderate temperatures on myristoyl-CoA metabolism and acyl-CoA thioesterase activity in the psychrophilic antarctic yeast Rhodotorula aurantiaca.
Sabri, Ahmed ULg; Bare, G.; Jacques, Philippe ULg et al

in Journal of Biological Chemistry (2001), 276(16), 12691-6

The inability of psychrophilic microorganisms to grow at moderate temperatures (>20 degrees C) presently represents an unresolved thermodynamic paradox. Here we report for the psychrophilic yeast ... [more ▼]

The inability of psychrophilic microorganisms to grow at moderate temperatures (>20 degrees C) presently represents an unresolved thermodynamic paradox. Here we report for the psychrophilic yeast Rhodotorula aurantiaca A19, isolated from Antarctic ice, that the inability to grow at temperatures close to 20 degrees C is associated with profound alterations in cell morphology and integrity. High performance liquid chromatography analysis of the intracellular acyl-CoA esters revealed an abnormal accumulation of myristoyl-CoA (C14-CoA) in cells cultivated close to the nonpermissive temperature. Its concentration (500 microm) was found to be 28-fold higher than in cells cultivated at 0 degrees C. If one considers its ability to disrupt membrane bilayers and to inhibit many cellular enzymes and functions, intracellular myristoyl-CoA accumulation in the psychrophile R. aurantiaca represents one of the principal causes of growth arrest at moderate temperatures. Intracellular acyl-CoA concentrations are believed to be regulated by thioesterase activity. Thus in an attempt to explore the mechanism by which temperature disrupts myristoyl-CoA metabolism, we isolated and characterized a long chain acyl-CoA thioesterase. The monomeric 80-kDa thioesterase from the psychrophilic yeast shows a very strong specificity for myristoyl-CoA. The affinity for substrate and the catalytic efficiency of the thioesterase are optimal below 5 degrees C (temperatures habitually experienced by the strain) and dramatically decrease with increasing temperature. The loss of affinity for substrate is related to the intracellular increase of myristoyl-CoA concentration. Our observations reveal one of the probable mechanisms by which temperature fixes the limit of growth for this psychrophilic yeast. [less ▲]

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See detailThe Uppermost Famennian around the world (Definition, biostratigraphical and sedimentological context)
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (2001), 18

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See detailTransduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation.
Minet, E.; Michel, G.; Mottet, Denis ULg et al

in Free Radical Biology & Medicine (2001), 31(7), 847-55

Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers ... [more ▼]

Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers the overexpression of genes coding for glycolytic enzymes and angiogenic factors. To be active HIF-1 must be phosphorylated. HIF-1 is a substrate for various kinase pathways including PI-3K and the MAP kinases ERK and p38. Several transduction pathways have been proposed which act downstream of putative oxygen sensors and lead to the activation of these kinases. In this review, we summarize some of the latest advances describing the possible signaling pathways leading to HIF-1 phosphorylation and subsequent activation. The physiological relevance of these regulations is also discussed. [less ▲]

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See detailLiège. La cité des Princes-Evêques. Du Musée Curtius au Trésor de la Cathédrale
George, Philippe ULg; Demoulin, Bruno ULg; Kupper, Jean-Louis ULg et al

in Feuilllets de la Cathédrale de Liège (2001)

Exposition d'une soixantaine d'oeuvres d'art du Musée Curtius au Trésor de la Cathédrale de Liège dans une scénographie combinée, parcours d'art et d'histoire de la principauté de Liège(2001-2009)

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See detailRandom matrix study of the phase structure of QCD with two colors
Vanderheyden, Benoît ULg; Jackson, A. D.

in Physical Review. D : Particles and Fields (2001), 64(7), 074016

We apply a random matrix model to the study of the phase diagram of QCD with two colors, two flavors, and a small quark mass. Although the effects of temperature are only included schematically, this ... [more ▼]

We apply a random matrix model to the study of the phase diagram of QCD with two colors, two flavors, and a small quark mass. Although the effects of temperature are only included schematically, this model reproduces most of the ground state predictions of chiral perturbation theory and also gives a qualitative picture of the phase diagram at all temperatures. It leads, however, to an unphysical behavior of the chiral order parameter and the baryon density in vacuum and does not support diquark condensation at arbitrarily high densities. A better treatment of temperature dependence leads to correct vacuum and small temperature properties. We compare our results at both high and low densities with the results of microscopic calculations using the Nambu-Jona-Lasinio (NJL) model and discuss the effects of large momentum scales on the variations of condensation fields with chemical potential. [less ▲]

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See detailA simple clinical tool to identify Asian women with osteoporosis
Lou, SQ; Koh, L; Yang, BY et al

in Journal of Rheumatology (2001), 28(S63), 26

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See detailEffects of liming on forest soil algal communities
Kostinov, I.; Carnol, Monique ULg; Dulière, J.-F. et al

in Algological Studies (2001), 102

The effects of the application of dolomite lime (5 t ha-1) on soil algal communities were investigated in sessile oak (Quercus petraea (MATT.) LIEB.) and Norway spruce (Picea abies (L.) KARST.) plots ... [more ▼]

The effects of the application of dolomite lime (5 t ha-1) on soil algal communities were investigated in sessile oak (Quercus petraea (MATT.) LIEB.) and Norway spruce (Picea abies (L.) KARST.) plots situated in the Belgian Ardenne. Chlorophyta (60 taxa) were by far the most diverse group, followed by Xanthophyceae (10 taxa), Bacillariophyceae (3 taxa), Cyanophyceae (2 taxa) and Euglenophyceae (1 taxon). In both forest types, liming lead to a significant increase in soil pH, exchangeable magnesium and calcium. In the limed Quercus plots available phosphorus and soil solution nitrate concentrations were also increased. The soil algal diversity was similar in oak and spruce control plots and in limed spruce plots. However, in the limed oak plots a significantly higher algal diversity was observed. On the basis of a CCA analysis, three clusters of plots could be distinguished: a) Picea control plots, b) limed Picea and control Quercus plots, c) limed Quercus plots. Both soil pH and nutrient availability seem to be important in determining algal species composition in these forest soils. [less ▲]

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See detailNitric oxide: does it play a role in the heart of the critically ill?
MASSION, Paul ULg; Moniotte, S.; Balligand, J. L.

in Current Opinion in Critical Care (2001), 7(5), 323-36

Nitric oxide regulates many aspects of myocardial function, not only in the normal heart but also in ischemic and nonischemic heart failure, septic cardiomyopathy, cardiac allograft rejection, and ... [more ▼]

Nitric oxide regulates many aspects of myocardial function, not only in the normal heart but also in ischemic and nonischemic heart failure, septic cardiomyopathy, cardiac allograft rejection, and myocarditis. Accumulating evidence implicates the endogenous production of nitric oxide in the regulation of myocardial contractility, distensibility, heart rate, coronary vasodilation, myocardial oxygen consumption, mitochondrial respiration, and apoptosis. The effects of nitric oxide promote left ventricular mechanical efficiency, ie, appropriate matching between cardiac work and myocardial oxygen consumption. Most of these beneficial effects are attributed to the low physiologic concentrations generated by the constitutive endothelial or neuronal nitric oxide synthase. By contrast, inducible nitric oxide synthase generates larger concentrations of nitric oxide over longer periods of time, leading to mostly detrimental effects. In addition, the recently identified beta3-adrenoceptor mediates a negative inotropic effect through coupling to endothelial nitric oxide synthase and is overexpressed in heart failure. An imbalance between beta 1 and beta2-adrenoceptor and beta3-adrenoceptor, with a prevailing influence of beta3-adrenoceptor, may play a causal role in the pathogenesis of cardiac diseases such as terminal heart failure. Likewise, changes in the expression of endothelial nitric oxide synthase or inducible nitric oxide synthase within the myocardium may alter the delicate balance between the effects of nitric oxide produced by either of these isoforms. New treatments such as selective inducible nitric oxide synthase blockade, endothelial nitric oxide synthase promoting therapies, and selective beta3-adrenoceptor modulators may offer promising new therapeutic approaches to optimize the care of critically ill patients according to their stage and specific underlying disease process. [less ▲]

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See detailSpatial aggregation of two-dimensional objects in raster data structures.
Bogaert, Jan ULg; Rousseau, R

in Applied Mathematics and Computation (2001), 119(2-3), 117-126

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See detailCentral amplification of somatosensory inputs: an evoked potentials study
DIVE, Dominique ULg; Schmetz, E.; Polis, M. et al

in Journal of Neurology (2001)

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See detailEffet de l’environnement proche sur la biodiversité entomologique en culture maraîchères de plein champ
Colignon, P.; Haubruge, Eric ULg; Hastir, P. et al

in Parasitica (2001), 56

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See detailApport de la tomographie par émission de positons pour la détection des tumeurs primitives lors de la découverte de métastases
Albérini, Jean-Louis; Belhocine, Tarik; Daenen, Frédéric ULg et al

in Bulletin du Cancer (2001), 88(5), 518-519

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See detailRadiative lifetime measurements and transition probabilities of astrophysical interest in Er III
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Bastin, Thierry ULg et al

in Monthly Notices of the Royal Astronomical Society (2001), 321

Radiative lifetimes of seven excited states of Er III have been measured using time-resolved laser-induced fluorescence following two-photon excitation. Relativistic Hartree-Fock calculations taking core ... [more ▼]

Radiative lifetimes of seven excited states of Er III have been measured using time-resolved laser-induced fluorescence following two-photon excitation. Relativistic Hartree-Fock calculations taking core-polarization effects into account are found to be in excellent agreement with the experimental results. A large set of new calculated transition probabilities is presented for many transitions of astrophysical interest. These results will be useful for investigating the composition of chemically peculiar stars. [less ▲]

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See detailNeuropathies canalaires et micro--traumatiques liees a la pratique sportive.
Wang, François-Charles ULg; Crielaard, Jean-Michel ULg

in Revue Médicale de Liège (2001), 56(5), 382-90

The more frequent entrapment neuropathies related to sport are described: thoracic outlet syndrome in aquatic athletes and pitchers, long thoracic neuropathy in tennis players, suprascapular neuropathy in ... [more ▼]

The more frequent entrapment neuropathies related to sport are described: thoracic outlet syndrome in aquatic athletes and pitchers, long thoracic neuropathy in tennis players, suprascapular neuropathy in volleyball and tennis players, ulnar nerve entrapment at the elbow in pitchers and at the wrist in cyclists, Morton's syndrome in runners and dancers. [less ▲]

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See detailEffect of Intravenous Platelet-Activating Factor on Bovine Pulmonary Mast Cells
Jolly, Sandra ULg; Thomas, Cédric; Genicot, Bruno et al

in Journal of Comparative Pathology (2001), 125(Aug-Oct), 81-89

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six ... [more ▼]

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six animals, which were killed approximately 10 min later. No macroscopical lesions were observed in the lung tissue of five control calves. On semi-thin toluidine-blue stained sections, MC cytoplasm showed profuse deep-blue granulation. In the lung tissues of PAF-treated calves, striking interstitial, alveolar and interlobular oedema and emphysema were observed. MC granules occurred at the periphery of the cytoplasm and MC nuclei were easily detectable. Moreover, the number of granules in the MC cytoplasm was remarkably low. A few granules with some metachromatic material were sometimes detected outside the cell limits. Ultrastructurally, the matrix pattern of the MC granules in lung tissues of control calves was either amorphous or granular. In lung tissues of the PAF-treated calves, the granular matrix pattern was pronounced, varying from fine- to coarse-grained, and the MCs were of reduced size, with many filiform processes and exocytotic vesicles. These findings indicate that pulmonary MC degranulation was induced by PAF in healthy calves. [less ▲]

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See detailFaut-il bannir l’épicéa au nom de la gestion durable ?
Claessens, Hugues ULg

in Forêt Wallonne (2001), 49-50

L'épicéa (Picea abies (L.) Karst.), introduit en 1810 dans la sylviculture belge, est devenu en un siècle la première essence du pays, couvrant près de 200 000 ha et participant largement au développement ... [more ▼]

L'épicéa (Picea abies (L.) Karst.), introduit en 1810 dans la sylviculture belge, est devenu en un siècle la première essence du pays, couvrant près de 200 000 ha et participant largement au développement socio-économique des régions rurales du pays et en particulier de l'Ardenne. Mais pour des raisons liées à la mauvaise décomposition de sa fane et à son ombrage, sa culture en futaie pure équienne dense remplit mal les fonctions écologiques de la forêt. Dans toute l'Europe occidentale, confrontée à ce même problème, naît alors une polémique entre les milieux écologistes et les sylviculteurs de l'épicéa : la culture de l'épicéa peut-elle s'envisager dans le cadre de la gestion durable? Dans ce contexte, cette réflexion s'appuie sur les études scientifiques de l'impact de la pessière sur l'environnement ainsi que sur les recherches en matière de sylvicultures alternatives pour montrer qu'une sylviculture raisonnée de l'épicéa, dans les conditions qui lui conviennent, est compatible avec la gestion durable, mais aura probablement comme conséquence une diminution de la surface de la pessière. Afin d'ancrer, notre réflexion sur des études concrètes, notre démonstration fait référence à la pessière belge. [less ▲]

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See detailEffects of insecticide treatments on insect density and diversity in vegetable open fields.
Colignon, P.; Hastir, Pierre; Gaspar, Charles ULg et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2001), 66(2a), 403-411

Vegetable open field areas increased for 15 years in Wallonia, mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agro-chimical residues (R.M.L.), biological pest ... [more ▼]

Vegetable open field areas increased for 15 years in Wallonia, mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agro-chimical residues (R.M.L.), biological pest control was developed and allowed to reduce the insecticide use, leading to have safer fresh products. Among cultivated species in Wallonia, leguminous crops represent more than 85% of the vegetable production. To assess the impact of insecticide treatment on both pests (mainly aphids) and beneficial insects (predators and parasitoids), broad bean (Vicia faba L.) fields were investigated during all the production duration. Twelve fields between Waremme and Hannut were visited weakly from May to July. In each field, control untreated and treated plots were investigated. Insects were caught using yellow traps and determined until the family level. Approximately 90.000 insects belonging to 59 major families (99% of captures) and 64 minor families were identified. These results showed that biodiversity in terms of family numbers was significantly higher in unsprayed plots. In addition, biodiversity and biomass (insect density) increased gradually during the season. Evaluation of pest and beneficial diversity and density was discussed in relation to aphicid (lambda-cyhalothrin, pirimicarb) treatments and the development of I.P.M. program in vegetable crops. [less ▲]

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See detailIron microbial communities in Belgian Frasnian carbonate mounds
Boulvain, Frédéric ULg; De Ridder, C.; Mamet, B. et al

in Facies (2001), 44

The Belgian Frasnian carbonate mounds occur in three stratigraphic levels in an overall backstepping succession. Petit-Mont and Arche Members form the famous red and grey “marble” exploited for ornamental ... [more ▼]

The Belgian Frasnian carbonate mounds occur in three stratigraphic levels in an overall backstepping succession. Petit-Mont and Arche Members form the famous red and grey “marble” exploited for ornamental stone since Roman times. The evolution and distribution of the facies in the mounds is thought to be associated with ecologic evolution and relative sea-level fluctuations. Iron oxides exist in five forms in the Frasnian mounds; four are undoubtedly endobiotic organized structures: (1) microstromatolites and associated forms (blisters, veils...), possibly organized in “endostromatolites”; (2) hematitic coccoids and (3) non dichotomic filaments. The filaments resemble iron bacteria of the Sphaerotilus- Leptothrix "group"; (4) networks of dichotomic filaments ascribable to fungi; (5) a red ferruginous pigment dispersed in the calcareous matrix whose distribution is related to the mound facies type. The endobiotic forms developed during the edification of the mounds, before cementation by fibrous calcite. The microbial precipitation of iron took place as long as the developing mounds were bathed by water impoverished in oxygen. [less ▲]

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See detailAbout the relationship between the kallikrein-kinin system and insulin
Damas, Jacques ULg; Liégeois, Jean-François ULg

in Current Topics in Peptide and Protein Research (2001), 4

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See detailSecular increase in the incidence of hip fractures in Belgium between 1984 and 1996: need for a concerted public health strategy.
Reginster, Jean-Yves ULg; Gillet, Pierre ULg; Gosset, Christiane ULg

in Bulletin of the World Health Organization (2001), 79(10), 942-6

OBJECTIVE: To determine the incidence of hip fractures (at the proximal end of the femur) in Belgium from 1984 to 1996. METHODS: Use was made of information from the national database on hospital bills ... [more ▼]

OBJECTIVE: To determine the incidence of hip fractures (at the proximal end of the femur) in Belgium from 1984 to 1996. METHODS: Use was made of information from the national database on hospital bills, which fully covers the annual hospital stays in the whole of the country. FINDINGS: The mean annual incidence of hip fractures increased from 107.8 to 140.5 per 100,000 inhabitants between 1984 and 1996. The incidence of fractures of the femoral shaft (diaphysis), taken as a control, remained stable. The female to male ratio of these hip fractures was 2.3:1. Although the incidence by age group was identical for males and females, the fractures occurred approximately seven years earlier in women than in men. The demographic changes observed in Belgium during this period accounted for only 10% of the observed increase in the number of hip fractures. CONCLUSION: If no comprehensive preventive policy is set up promptly, there will be a sevenfold increase in the incidence of hip fractures between now and the year 2050 in Belgium. [less ▲]

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See detailC.R. de K. Klingebiel, Bibliographie linguistique (1983-1997) de l'ancien occitan
Henrard, Nadine ULg

in Moyen Age (Le) (2001), CVII(3-4), 614-616

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See detailUtilisation des gènes à effet majeur en sélection laitière. Un exemple: le gène Pit-1
Renaville, Robert ULg; Parmentier, Isabelle; Fontaine, Sandrine et al

in Les Elevages belges (2001), 4

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See detailDefict in recognition of emotional facial expression are still oresent in alcoholics after mid to long term abstinence
Kornreich, C; Blairy, Sylvie ULg; Philippot, P et al

in Journal of Studies on Alcohol (2001), 62(4), 533-542

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See detailLa gestion des données dans le système SAS sous Windows v6.12
Fonton, N. H.; Claustriaux, Jean-Jacques ULg

in Notes de biométrie et d'informatique (2001), 1

The management of data is one of the major difficulties of the users in the SAS system. The note presents the procedures of data management after a brief summary on the organization and creation of data ... [more ▼]

The management of data is one of the major difficulties of the users in the SAS system. The note presents the procedures of data management after a brief summary on the organization and creation of data. Some procedures for statistics analysis are also presented. [less ▲]

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See detailExperimental M1 Transition Rates in Highly Charged Krypton Ions
Träbert, E.; Beiersdorfer, P.; Brown, G. V. et al

in Physical Review. A (2001), 64

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See detailEffects of 8-epi-Pgf2alpha on isolated bronchial smooth muscle of healthy and heaves-affected horses
Kirschvink, Nathalie; Art, Tatiana ULg; Lekeux, Pierre ULg et al

in Journal of Veterinary Pharmacology & Therapeutics (2001), 24(3), 215-221

8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstrictor in airways from healthy laboratory animals and healthy humans, but it has ... [more ▼]

8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstrictor in airways from healthy laboratory animals and healthy humans, but it has never been studied in diseased airways. Here, the bronchoconstrictive capacity of 8-epi-PGF2alpha on isolated bronchial rings (BR) of healthy and heaves-affected horses was evaluated by comparing the maximal effect and the potency of 8-epi-PGF2alpha to those of (1) acetylcholine (ACh), (2) its stereoisomer PGF2alpha and (3) its synthetic receptor agonist, U46619. Furthermore, the potential capacity of 8-epi-PGF2alpha to enhance the cholinergic (ACh) responsiveness of bronchial smooth muscle was investigated. 8-Epi-PGF2alpha contracted BR with a rank order of efficacy of Ach > U44619 > PGF2alpha > 8-epi-PGF2alpha in both healthy and heaves-affected horses. The contractile maximal response elicited by 8-epi-PGF2alpha was significantly smaller than that elicited by the other drugs, but was significantly higher in BR from heaves-affected horses than in those sampled in healthy horses, whilst pD2 values were similar. A subthreshold concentration of 8-epi-PGF2alpha (10-7 M) did not induce in vitro cholinergic hyper-responsiveness in BR of either healthy or heaves-affected horses. In conclusion, it has been demonstrated that 8-epi-PGF2alpha is an in vitro bronchoconstrictor of minor importance in healthy horses, but whose efficacy is significantly increased in heaves-affected horses. [less ▲]

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See detailThe karyotype of the Formentera island garden dormouse, Eliomys quercinus ophiusae
Ramalhinho, Graça; Libois, Roland ULg

in Belgian Journal of Zoology (2001), 131(1), 83-85

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See detailLes bois de cerf : revue de littérature scientifique
Crigel, M-H; Balligand, Marc ULg; Heinen, Ernst ULg

in Annales de Médecine Vétérinaire (2001), 145

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See detailSerum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria.
Verhoef, H.; West, C. E.; Ndeto, P. et al

in American Journal of Clinical Nutrition (2001), 74(6), 767-75

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum ... [more ▼]

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum transferrin receptor concentrations are not or are only marginally influenced by the inflammatory response to infection. OBJECTIVE: We assessed iron status and examined the relation between serum transferrin receptor concentrations and malaria in children aged 2-36 mo who were asymptomatic for malaria. DESIGN: This was a community-based cluster survey (n = 318). RESULTS: Prevalences of malaria, anemia (hemoglobin concentration <110 g/L), iron deficiency (serum ferritin concentration <12 microg/L), and iron deficiency anemia were 18%, 69%, 53%, and 46%, respectively. Malaria was associated with lower mean hemoglobin concentrations (92.7 compared with 104.1 g/L; P = 0.0001) and higher geometric mean serum concentrations of transferrin receptor (11.4 compared with 7.8 mg/L; P = 0.005), ferritin (21.6 compared with 11.9 microg/L; P = 0.05), and C-reactive protein (12.5 compared with 6.8 mg/L; P = 0.004). There was no evidence for an association between serum concentrations of C-reactive protein and transferrin receptor. Children with malaria had higher serum transferrin receptor concentrations than expected for the degree of anemia, even after adjustment for inflammation indicated by serum C-reactive protein concentration quartiles (P = 0.02). CONCLUSIONS: Our findings are consistent with the notion that malaria-induced hemolysis is accompanied by increased erythropoiesis. Serum transferrin receptor concentration is not useful for detecting iron deficiency in individuals with malaria. Individuals with high concentrations of serum C-reactive protein or similar acute phase reactants should be excluded from analysis if serum ferritin concentrations <12 microg/L are to be used to measure iron deficiency in malaria-endemic areas. [less ▲]

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See detailUse of molecular tools to enhance antagonistics activity of yeasts against postharvest diseases of apples
Jijakli, Haissam ULg; De Clercq, Deborah; Cognet, Stéphane et al

in Phytopathology (2001), 91(6 (supplément)), 154

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See detailPotential impact of the main benthic amphipods on the eastern Weddell Sea shelf ecosystem (Antarctica)
Dauby, Patrick ULg; Scailteur, Yves; Chapelle, Gauthier et al

in Polar Biology (2001), 24

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See detailInvestigation of defect levels in Mg-doped GaN Schottky structures by thermal admittance spectroscopy
Nguyen, Ngoc Duy ULg; Germain, Marianne; Schmeits, Marcel et al

in Physica Status Solidi B. Basic Research (2001), 228

Schottky structures based on Mg-doped GaN layers grown by metalorganic chemical vapor deposition (MOCVD) on sapphire substrate are studied by thermal admittance spectroscopy from 90 K to room temperature ... [more ▼]

Schottky structures based on Mg-doped GaN layers grown by metalorganic chemical vapor deposition (MOCVD) on sapphire substrate are studied by thermal admittance spectroscopy from 90 K to room temperature. Evidence of two impurity levels results from the analysis of the observed peaks in the conductance curves, whose positions and strengths are temperature dependent. The experimental results are analyzed within a detailed theoretical study of the steady-state and small-signal electrical characteristics of the structure. Numerical simulations are based on the solution of the basic semiconductor equations for the structure consisting of two Schottky diodes connected back-to-back by a conduction channel formed by the GaN layer. [less ▲]

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See detailCollaborative learning in an educational robotics environment
Denis, Brigitte ULg; Hubert, Sylviane

in Computer in Human Behavior (2001), 17(5-6), 465-480

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See detailUmetnost Čarlsa Simića
Delville, Michel ULg

in ProFemina : Časopis za żensku knjiżevnost I kulturu (2001), 27

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See detailCysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.
Bounaga, S.; Galleni, Moreno ULg; Laws, A. P. et al

in Bioorganic & medicinal chemistry (2001), 9(2), 503-10

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion ... [more ▼]

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site. [less ▲]

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