References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailThe DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
Bonjean, K.; De Pauw-Gillet, Marie-Claire ULg; Defresne, Marie-Paule ULg et al

in Biochemistry (1998), 37(15), 5136-46

Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of Cryptolepis sanguinolenta. It is characterized by a multiplicity of host-mediated biological activities, including ... [more ▼]

Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of Cryptolepis sanguinolenta. It is characterized by a multiplicity of host-mediated biological activities, including antibacterial, antiviral, and antimalarial properties. To date, the molecular basis for its diverse biological effects remains largely uncertain. Several lines of evidence strongly suggest that DNA might correspond to its principal cellular target. Consequently, we studied the strength and mode of binding to DNA of cryptolepine by means of absorption, fluorescence, circular, and linear dichroism, as well as by a relaxation assay using DNA topoisomerases. The results of various optical and gel electrophoresis techniques converge to reveal that the alkaloid binds tightly to DNA and behaves as a typical intercalating agent. In DNAase I footprinting experiments it was found that the drug interacts preferentially with GC-rich sequences and discriminates against homo-oligomeric runs of A and T. This study has also led to the discovery that cryptolepine is a potent topoisomerase II inhibitor and a promising antitumor agent. It stabilizes topoisomerase II-DNA covalent complexes and stimulates the cutting of DNA at a subset of preexisting topoisomerase II cleavage sites. Taking advantage of the fluorescence of the indoloquinoline chromophore, fluorescence microscopy was used to map cellular uptake of the drug. Cryptolepine easily crosses the cell membranes and accumulates selectively into the nuclei rather than in the cytoplasm of B16 melanoma cells. Quantitative analyses of DNA in cells after Feulgen reaction and image cytometry reveal that the drug blocks the cell cycle in G2/M phases. It is also shown that the alkaloid is more potent at inhibiting DNA synthesis rather than RNA and protein synthesis. Altogether, the results provide direct evidence that DNA is the primary target of cryptolepine and suggest that this alkaloid is a valid candidate for the development of tumor active compounds. [less ▲]

Detailed reference viewed: 75 (1 ULg)
Peer Reviewed
See detailDépression et suicide : Aspects biologiques
ANSSEAU, Marc ULg; PITCHOT, William ULg

in Neuro-psy (1998)

Detailed reference viewed: 16 (5 ULg)
Peer Reviewed
See detailZolmitriptan, a 5-HT1B/1D receptor agonist for the acute oral treatment of migraine: a multicentre, dose-range finding study.
Dahlof, C.; Diener, H. C.; Goadsby, P. J. et al

in European Journal of Neurology (1998), 5(6), 535-543

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral ... [more ▼]

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral zolmitriptan (5, 10, 15 and 20 mg) in the treatment of single acute migraine attacks. Of 1181 patients randomized, 840 were evaluable for the primary efficacy analysis. Headache response rates (a reduction in headache intensity from severe or moderate at baseline to mild or no pain at 2 hours post-treatment) were similar across the zolmitriptan dose groups (66%, 71%, 69% and 77% for 5 mg, 10 mg, 15 mg and 20 mg, respectively) and were significantly higher than that for placebo (19%; all groups P < 0.001). A headache response was reported at 1 hour by 40-50% of zolmitriptan recipients (16% placebo). At 2 hours post dose, 39-47% of zolmitriptan-treated patients were pain-free, compared with 1% of placebo recipients. Headache recurrence occurred in 21-29% (upper 95% CI 37.1) of zolmitriptan-treated patients and in 65% (95% CI 38.3, 85.8) of placebo recipients. Zolmitriptan was well tolerated at each dose. The most commonly reported adverse events were asthenia, dizziness, paraesthesia and feelings of heaviness. Most adverse events were of mild or moderate intensity and were transient. The frequency of adverse events was dose-related. Although, zolmitriptan 5 mg exhibited the most favourable efficacy and tolerability profile, the dose response data suggest that lower doses would also offer significant efficacy. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

Detailed reference viewed: 16 (1 ULg)
Peer Reviewed
See detailPharma-Clinics. Essais cliniques medicamenteux: importance et role du medecin generaliste .
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(1), 17-20

Clinical trials are an essential step in the development of a drug. They must be conducted according to strict rules called "Good Clinical Practice" or GCP. GCP requirements aim to guarantee a perfect ... [more ▼]

Clinical trials are an essential step in the development of a drug. They must be conducted according to strict rules called "Good Clinical Practice" or GCP. GCP requirements aim to guarantee a perfect methodology in the planning, realization and interpretation of clinical trials. The latter can be divided in four phases: phase 1 aiming to demonstrate the safety and to investigate the pharmacokinetics/metabolism of the drug in healthy volunteers; phase 2 aiming to study the intrinsic activity (generally versus a placebo) and safety of the compound in a rather small number of (hospitalized) patients; phase 3 aiming to confirm the comparative efficacy (versus a placebo or a reference drug) and safety of the pharmacological agent in a quite large number of (ambulatory) patients; and phase 4 carried out after commercialization, to verify the clinical utility of the drug in conditions of daily practice. Because he/she occupies a crucial position in the recruitment and follow-up of outpatients, the general practitioner should play a more active role in clinical trials, provided that he/she could work in collaboration with academic centers specialized in clinical pharmacology which can help to perform studies in accordance with GCP requirements. [less ▲]

Detailed reference viewed: 49 (1 ULg)
Full Text
Peer Reviewed
See detailIntracellular and extracellular vaccinia virions enter cells by different mechanisms
Vanderplasschen, Alain ULg; Hollinshead, M.; Smith, G. L.

in Journal of General Virology (The) (1998), 79(Pt 4), 877-887

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailLes mecanismes responsables de la resistance aux insecticides chez les insectes et les acariens.
Haubruge, Eric ULg; Amichot, M.

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(3),

Detailed reference viewed: 73 (37 ULg)
Full Text
Peer Reviewed
See detailIsotope splitting of the zero-phonon line of Fe2+ in cubic III-V semiconductors
Colignon, David ULg; Mailleux, Éric; Kartheuser, Eduard ULg et al

in Solid State Communications (1998), 105(4), 205-209

A theoretical study of the isotopic-mass dependence of the internal transitions of Fe2+ at a cation site in a cubic zinc-blende semiconductor is presented. The model used is based on crystal-field theory ... [more ▼]

A theoretical study of the isotopic-mass dependence of the internal transitions of Fe2+ at a cation site in a cubic zinc-blende semiconductor is presented. The model used is based on crystal-field theory and includes the spin-orbit interaction and a weak dynamic Jahn-Teller coupling between the (5) Gamma(5) excited manifold of Fe2+ and a local vibrational mode (LVM) of Gamma(5) symmetry. The mass dependence of the LVM frequency is described, in the harmonic approximation, within two different limits: the rigid-cage model and a molecular model. In the rigid-cage model, the Fe2+ ion undergoes a displacement but the rest of the lattice is fixed. In this case, a simple M-1/2 dependence of the frequency is obtained and the Jahn-Teller energy, E-JT, is independent of the mass. In the molecular model, the four nearest neighbors of the magnetic ion are allowed to move and the LVM then behaves as the Gamma(5) mode of a MX4 tetrahedral molecule leading to a more complicated dependence of the frequency on the isotopic mass and to a mass-dependence of E-JT. The theoretical results obtained with these two models are compared with the observed isotopic shifts of the zero-phonon lines in InP:Fe and GaP:Fe corresponding to an optical transition between the vibronic Gamma(1) ground state and the lowest Gamma(5) state originating from the (5) Gamma(5) excited orbital multiplet. A prediction of the isotopic shifts of the zero-phonon line in GaAs:Fe is also presented. (C) 1997 Elsevier Science Ltd. [less ▲]

Detailed reference viewed: 31 (5 ULg)
Full Text
Peer Reviewed
See detailUne nouvelle tentative de commentaire de la strophe Yt 5. 7
Swennen, Philippe ULg

in Studia Iranica (1998), 27(2), 205-212

Detailed reference viewed: 27 (4 ULg)
Peer Reviewed
See detailL'échangeur, exercice structuré en dynamique des groupes
Faulx, Daniel ULg

in Cahiers Internationaux de Psychologie Sociale (1998), 3

Detailed reference viewed: 496 (37 ULg)
Full Text
See detailOver de cautio iudicatum solvi en de herziening ten gronde - case note (CFI Brussels 10 September 1996)
Wautelet, Patrick ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1998), (1998), 50-57

In this short comment on a decision of the Court of First Instance of Brussels I touch upon two classic issues of cross-border litigation : first the obligation which may be imposed on a foreign plaintiff ... [more ▼]

In this short comment on a decision of the Court of First Instance of Brussels I touch upon two classic issues of cross-border litigation : first the obligation which may be imposed on a foreign plaintiff to post bond and second the prohibition for the court addressed to review a foreign decision on the merits. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailOn the appropriateness of marginal models for repeated measurements in clinical trials
Lindsey, James ULg; Lambert, Philippe ULg

in Statistics in Medicine (1998), 17

Although models developed directly to describe marginal distributions have become widespread in the analysis of repeated measurements, some of their disadvantages are not well enough known. These include ... [more ▼]

Although models developed directly to describe marginal distributions have become widespread in the analysis of repeated measurements, some of their disadvantages are not well enough known. These include producing profile curves that correspond to no possible individual, possibly showing that a treatment is superior on average when it is poorer for each individual subject, implicitly generating complex and implausible physiological explanations, including underdispersion in subgroups, and sometimes corresponding to no possible probabilistic data generating mechanism. We conclude that such marginal models may sometimes be appropriate for descriptive observational studies, such as sample surveys in epidemiology, but should only be used with great care in causal experimental settings, such as clinical trials. [less ▲]

Detailed reference viewed: 41 (4 ULg)
Peer Reviewed
See detailCommentaires sur les travaux du bureau ABC
Fecher-Bourgeois, Fabienne ULg

in Bulletin de Documentation du Ministère des Finances (1998), LVIIIè année, n°5(Septembre - octobre 1998),

Detailed reference viewed: 13 (5 ULg)
Peer Reviewed
See detailL'erytheme necrolytique migrateur.
Dandrifosse, J. F.; Dandrifosse, A. C.; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1998), 53(12), 778-83

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to ... [more ▼]

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to glucagonoma treatments, the administration of corticoids, aminoacids, zinc or essential fatty acids can be helpful. There exist several etiological hypotheses for NME. These are based on modifications of pancreatic enzyme activities and on variations of aminoacids, fatty acids, zinc or glucagon concentrations. [less ▲]

Detailed reference viewed: 40 (0 ULg)
Peer Reviewed
See detailActualites therapeutiques 1997-1998 (1). Seconde partie.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(9), 518-23

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be stressed. This second part is devoted to drugs acting on infectious, rheumatoid, immunologic, oncologic and urogenital diseases. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailHydrolysis Of The Dimethyl Ester Of N-Succinylphenylalanine, A Model Of Polyesteramides, In The Presence Of Papain - Kinetic Study And Computer Simulation
David, C.; Lefèbvre, F.; Brasseur, Robert ULg et al

in Enzymes In Polymer Synthesis (1998), 684

Our work is concerned with the kinetics of enzymatic hydrolysis of substrates containing ester and amide groups and with the interactions between the active site of the enzyme and the function to be ... [more ▼]

Our work is concerned with the kinetics of enzymatic hydrolysis of substrates containing ester and amide groups and with the interactions between the active site of the enzyme and the function to be hydrolyzed, special attention is paid to differences between a soluble substrate which can fit the active site and a crystalline or semi-crystalline substrate. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailProtection against voltage collapse
Van Cutsem, Thierry ULg; Fernandez, Jose Luis; Henville, Charles F. et al

in ELECTRA (1998), (179), 110-126

Detailed reference viewed: 24 (1 ULg)
Full Text
Peer Reviewed
See detailThymic expression of neuroendocrine self-peptide precursors: role in T-cell survival and self-tolerance
Geenen, Vincent ULg; Kecha, Ouafae; Martens, Henri ULg

in Journal of Neuroendocrinology (1998), 10

Detailed reference viewed: 9 (3 ULg)
See detailEtre chasseur et gestionnaire des zones humides.
Doucet, Jean-Louis ULg

in Parcs & Réserves (1998), 53(1-2),

Detailed reference viewed: 15 (4 ULg)
See detailNéoplasie mammaire plurifocale en généralisation osseuse
Blocklet, Didier; Seret, Alain ULg; Schoutens, André

in Revue Médicale de Bruxelles (1998), 19

Clinical case.

Detailed reference viewed: 267 (0 ULg)
Peer Reviewed
See detailEarly clinical experience with subcutaneous naratriptan in the acute treatment of migraine: a dose-ranging study.
Dahlof, C.; Hogenhuis, L.; Olesen, J. et al

in European Journal of Neurology (1998), 5(5), 469-477

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to ... [more ▼]

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to evaluate the efficacy, safety and tolerability of five doses of subcutaneous (sc) naratriptan (0.5, 1, 2.5, 5 or 10 mg) in comparison with sc sumatriptan (6 mg) and placebo in the acute treatment of a moderate/severe migraine attack. Headache relief [reduction of headache severity from moderate or severe (grade 2/3) to mild or none (grade 1/0)] at 1 and 2 h after each dose, was reported by a statistically significantly higher proportion of patients for all doses of sc naratriptan and sc sumatriptan (6 mg) than for placebo. The percentages of patients with headache relief at 2 h post-dose were: naratriptan (0.5 mg) 65%, (1 mg) 75%, (2.5 mg) 83%, (5 mg) 94% and (10 mg) 91%; sumatriptan (6 mg) 89%; placebo 41%, (P < 0.005). The earliest report of a statistically significant difference compared with placebo for the times assessed was with sc naratriptan (10 mg) at 10 min post-dose (P = 0.023). The percentages of patients reporting adverse events were dose-related; sc naratriptan (0.5 mg) 33%, (1 mg) 29%, (2.5 mg) 43%, (5 mg) 59% and (10 mg) 71%; sc sumatriptan 53%; placebo 22%. There were no clinically significant changes in electrocardiogram (ECG), vital signs or laboratory parameters. Systemic exposure increased proportionally to the dose, the absorption of sc naratriptan was rapid (tmax = 10 min) and the half-life was 5 h. In conclusion, sc naratriptan was an effective and well-tolerated acute treatment for migraine. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

Detailed reference viewed: 26 (1 ULg)
See detailCase Management voor geriatrische patienten en hun families : Het klinisch model van belgische projecten
Borgermans, L.; Abraham, I.; Milisen, K. et al

in Tijdschrift voor de Geschiedenis der Geneeskunde, Natuurwetenschappen, Wiskunde en Techniek (1998), 54(6), 427-435

Detailed reference viewed: 30 (0 ULg)
Peer Reviewed
See detailLa neuropathie diabetique: donnees epidemiologiques et predictives.
Scheen, André ULg

in Diabètes & Métabolism (1998), 24 Suppl 3

Neuropathy is a classical complication of diabetes mellitus, to the same extent as micro- and macroangiopathy. Diabetic neuropathy can be schematically divided into peripheral neuropathy, especially in ... [more ▼]

Neuropathy is a classical complication of diabetes mellitus, to the same extent as micro- and macroangiopathy. Diabetic neuropathy can be schematically divided into peripheral neuropathy, especially in the lower limbs (distal polyneuropathy), and autonomic neuropathy, present in all systems (cardiovascular, gastrointestinal, urogenital and even pulmonary abnormalities). Detection should be based on an oriented anamnesis and a careful physical examination. Complementary exams may be performed in order to confirm the diagnosis and assess the severity of the neuropathy. While the diagnosis of peripheral neuropathy is essentially based on clinical examination, that of autonomic neuropathy has been markedly facilitated by simple standardised tests for early detection of cardiac autonomic neuropathy. Depending on the terminology, the diagnostic criteria and the characteristics of the population, the prevalence of diabetic neuropathy can range from 15 to 100%. However, all studies agree that prevalence is important in both types of diabetes (Type 1 and Type 2), that it increases with age and disease duration, and that it is inversely related to the quality of glycaemic control. Detection of neuropathy is an essential step in the clinical approach to diabetic patients, mainly because of the prognosis linked to such a diagnosis, at both an early and late stage of the disease. Once neuropathy is diagnosed, the physician should provide specific advice to diabetic patients in order to prevent possible dramatic complications. [less ▲]

Detailed reference viewed: 65 (1 ULg)
Full Text
Peer Reviewed
See detailAminoglycoside 6 '-N-Acetyltransferase Variants Of The Ib Type With Altered Substrate Profile In Clinical Isolates Of Enterobacter Cloacae And Citrobacter Freundii
Casin, I.; Bordon, F.; Bertin, P. et al

in Antimicrobial Agents and Chemotherapy (1998), 42(2), 209-15

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6'-N acetyltransferase type II [AAC(6 ... [more ▼]

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6'-N acetyltransferase type II [AAC(6')-II] production, which conferred reduced susceptibility to gentamicin but not to amikacin or isepamicin. Aminoglycoside acetyltransferase assays suggested the synthesis in the three strains of an AAC(6') which acetylated amikacin practically as well as it acetylated gentamicin in vitro. Both compounds, however, as well as isepamicin, retained good bactericidal activity against the three strains. The aac genes were borne by conjugative plasmids (pLMM562 and pLMM564 of ca. 100 kb and pLMM563 of ca. 20 kb). By PCR mapping and nucleotide sequence analysis, an aac(6')-Ib gene was found in each strain upstream of an ant(3")-I gene in a sulI-type integron. The size of the AAC(6')-Ib variant encoded by pLMM562 and pLMM564, AAC(6')-Ib7, was deduced to be 184 (or 177) amino acids long, whereas in pLMM563 a 21-bp duplication allowing the recruitment of a start codon resulted in the translation of a variant, AAC(6')-Ib8, of 196 amino acids, in agreement with size estimates obtained by Western blot analysis. Both variants had at position 119 a serine instead of the leucine typical for the AAC(6')-Ib variants conferring resistance to amikacin. By using methods that predict the secondary structure, these two amino acids appear to condition an alpha-helical structure within a putative aminoglycoside binding domain of AAC(6')-Ib variants. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailIncreased parathyroïd hormone secretions as a risk factor for femoral osteoporosis in elderly women
Deroisy, Rita ULg; Collette, Julien ULg; Dewe, W. et al

in Osteoporosis International (1998), 8(S3), 40

Detailed reference viewed: 26 (9 ULg)
See detailDe la protection possessoire à la maxime "Spoliatus ante omnia restituendus" : possession, détention et pouvoir de fait
Lecocq, Pascale ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

Detailed reference viewed: 32 (1 ULg)
Full Text
Peer Reviewed
See detailImproved IL-2 detection for determination of helper T lymphocyte precursor frequency in limiting dilution assay
Winandy, Marie ULg; Lewalle, Philippe; Deneys, Véronique et al

in Journal of Immunological Methods (1998), 215

In the context of allogeneic bone marrow transplantation, an accurate estimate of the risk of developing graft-versus-host disease GVHD. is of major interest. The pre-transplant frequency of donor’s ... [more ▼]

In the context of allogeneic bone marrow transplantation, an accurate estimate of the risk of developing graft-versus-host disease GVHD. is of major interest. The pre-transplant frequency of donor’s helper T-lymphocyte precursors HTLp. directed against host’s antigens may be helpful in predicting this risk. This technique relies on an indirect measurement of interleukin-2 IL-2. secreted by the HTLp, as assessed by the proliferation of an IL-2 dependent cell line. Many authors use the murine CTLL-2 cell line in this assay, but these cells do not respond to the presence of minute amounts of IL-2 in the culture medium, and thus do not discriminate between the absence or the presence of very low levels of IL-2. We therefore decided to compare CTLL-2 with another IL-2 dependent cell line, the murine A9.12 cell line. A comparison was made using serial dilutions of recombinant human IL-2, limiting dilutions of baby hamster kidney BHK. cells transfected with human IL-2 gene and in the context of clinical tests performed for the detection of pre-transplant HTLp. Both the sensitivity and reliability of the tests were better using A9.12. We conclude that the A9.12 cell line might be a more suitable tool for pre-transplant HTLp determinations before allogeneic bone marrow transplantation or whenever low IL-2 levels are to be measured. [less ▲]

Detailed reference viewed: 11 (2 ULg)
Peer Reviewed
See detailadaptation in neonatalogy of the once-daily concept of aminoglycoside administration: evaluation of a dosing chart for amikacin in an intensive care unit.
Battisti, Oreste ULg; Langhendries, J. P.; Bertrand, J. M. et al

in Biology of the Neonate (1998), 74

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailHigh-frequency oscillatory ventilation in neonatal RDS:initial volume optimization an respiratory mechanics
Masendu, Kalenga; Battisti, Oreste ULg; Bertrand, jean-marie et al

in Journal of Applied Physiology (1998), 84

Detailed reference viewed: 16 (0 ULg)
Full Text
See detailQuantitative palynology in late and latest Famennian swamp environments, an accurate tool for marine / non-marine correlation.
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (1998), 15

Detailed reference viewed: 12 (1 ULg)
Peer Reviewed
See detailLe prématuré confronté aux troubles de l'attachement. Prévention et prise en charge.
Battisti, Oreste ULg; Adant-François, A.; Bertrand, J. M. et al

in Archives Françaises de Pédiatrie (1998), 5

Detailed reference viewed: 125 (9 ULg)
Full Text
Peer Reviewed
See detailIsolation and characterization of photoactive complexes of NADPH : protochlorophyllide oxidoreductase from wheat
Chahdi, M. A. O.; Schoefs, B.; Franck, Fabrice ULg

in Planta (1998), 206(4), 673-680

A photoactive substrate-enzyme complex of the NADPH:protochlorophyllide oxidoreductase (POR; EC 1.3.1.33) was purified from etiolated Triticum aestivum L. by gel chromatography after solubilization of ... [more ▼]

A photoactive substrate-enzyme complex of the NADPH:protochlorophyllide oxidoreductase (POR; EC 1.3.1.33) was purified from etiolated Triticum aestivum L. by gel chromatography after solubilization of prolamellar bodies by dodecyl-maltoside. Irradiation by a 1-ms flash induced the phototransformation of protocholorophyllide a (Pchlide) with -196 degrees C absorbance and emission maxima at 640 and 643 nm, respectively. The apparent molecular weight of this complex was 112 +/- 24 kDa, which indicates aggregation of enzyme subunits. By lowering the detergent concentration in the elution buffer, a 1080 +/- 250-kDa particle was obtained which displayed the spectral properties of the predominant form of photoactive Pchlide in vivo (-196 degrees C absorbance and fluorescence maxima at 650 and 653 nm). In this complex, FOR was the dominant polypeptide. Gel chromatography in the same conditions of an irradiated sample of solubilized prolamellar bodies indicated rapid disaggregation of the complex after Pchlide phototransformation. High performance liquid chromatographic analysis of the FOR complexes obtained using two detergent concentrations indicates a possible association of zeaxanthin and violaxanthin with the photoactive complex. [less ▲]

Detailed reference viewed: 10 (0 ULg)
See detailLes goûts et les odeurs, ça peut se discuter.
Blecker, Christophe ULg; Willem, Georges

in Probio (1998), (4), 289-315

Detailed reference viewed: 6 (2 ULg)
See detailTroubles de voisinage : du fait positif à l'événement accidentel, en passant par l'omission
Lecocq, Pascale ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

Detailed reference viewed: 16 (1 ULg)
Peer Reviewed
See detailA theoretial investigation of neutral francium
Biémont, Emile ULg; Quinet, Pascal ULg; Van Renterghem, V.

in Journal of Physics : B Atomic Molecular & Optical Physics (1998), 31

Detailed reference viewed: 3 (1 ULg)
Peer Reviewed
See detailAccuracy and feasibility of contrast echocardiography for detection of perfusion defects in routine practice: comparison with wall motion and technetium-99m sestamibi single-photon emission computed tomography. The Nycomed NC100100 Investigators.
Marwick, T. H.; Brunken, R.; Meland, N. et al

in Journal of the American College of Cardiology (1998), 32(5), 1260-9

OBJECTIVES: We sought to assess the feasibility and accuracy of myocardial contrast echocardiography (MCE) using standard imaging approaches for the detection of perfusion defects in patients who had a ... [more ▼]

OBJECTIVES: We sought to assess the feasibility and accuracy of myocardial contrast echocardiography (MCE) using standard imaging approaches for the detection of perfusion defects in patients who had a myocardial infarction (MI). BACKGROUND: Myocardial contrast echocardiography may be more versatile than perfusion scintigraphy for identifying the presence and extent of perfusion defects after MI. However, its reliability in routine practice is unclear. METHODS: Fundamental or harmonic MCE was performed with continuous or triggered imaging in 203 patients with a previous MI using bolus doses of a perfluorocarbon-filled contrast agent (NC100100). All patients underwent single-photon emission computed tomography (SPECT) after the injection of technetium-99m (Tc-99m) sestamibi at rest. Quantitative and semiquantitative SPECT, wall motion and digitized echocardiographic data were interpreted independently. The accuracy of MCE was assessed for detection of segments and patients with moderate and severe sestamibi-SPECT defects, as well as for detection of patients with extensive perfusion defects (>12% of left ventricle). RESULTS: In segments with diagnostic MCE, the segmental sensitivity ranged from 14% to 65%, and the specificity varied from 78% to 95%, depending on the dose of contrast agent. Using both segment- and patient-based analysis, the greatest accuracy and proportion of interpretable images were obtained using harmonic imaging in the triggered mode. For the detection of extensive defects, the sensitivity varied from 13% to 48%, with specificity from 63% to 100%. Harmonic imaging remained the most accurate approach. Time since MI and SPECT defect location and intensity were all determinants of the MCE response. The extent of defects on MCE was less than the extent of either abnormal wall motion or SPECT abnormalities. The combination of wall motion and MCE assessment gave the best balance of sensitivity (46% to 55%) and specificity (82% to 83%). CONCLUSIONS: Although MCE is specific, it has limited sensitivity for detection of moderate or severe perfusion defects, and it underestimates the extent of SPECT defects. The best results are obtained by integration with wall motion. More sophisticated methods of acquisition and interpretation are needed to enhance the feasibility of this technique in routine practice. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailInfluence de facteurs abiotiques ou biotiques sur l'evaluation de la sensibilite d'Aphidius rhopalosiphi De Stefani-Perez a la phosalone.
Guelton, O.; Deleu, R.; Schiffers, Bruno ULg et al

in Parasitica (1998), 54(2-3),

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des ... [more ▼]

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des céréales. L'influence de l'humidité relative, de la photo période, du mode de conservation des momies ainsi que du sexe des insectes sur la sensibilité des parasitoïdes à la phosalone a été étudiée. L'humidité relative influence le plus la sensibilité des insectes lors des essais, le mode de conservation des momies se révèle important lui aussi. [less ▲]

Detailed reference viewed: 19 (6 ULg)
Full Text
Peer Reviewed
See detailLa succession des régions aux obligations aquiliennes de l'Etat relatives à la voirie
Delnoy, Michel ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

Detailed reference viewed: 13 (1 ULg)
Peer Reviewed
See detailL'embolisation scrotale antegrade de la varicocele--resultats.
Frangi, I.; Keppenne, Véronique ULg; Coppens, Luc ULg et al

in Acta Urologica Belgica (1998), 66(4), 5-8

The aim of this study is to judge the effectiveness of the new treatment of varicoceles, introduced in 1987 by Tauber: the antegradal scrotal sclerotherapy of varicoceles. From february 1996 to april 1998 ... [more ▼]

The aim of this study is to judge the effectiveness of the new treatment of varicoceles, introduced in 1987 by Tauber: the antegradal scrotal sclerotherapy of varicoceles. From february 1996 to april 1998, we have realised 150 antegrade embolisations of varicoceles. The study is lead on 75 patients with mean time follow-up of 12 months. Patient's mean age is 20 years. 85% of patients had a grade 3 left varicocele and 15% a grade 2 left varicocele. The criterium of success rests on the lack of veinous flow-back during clinical examination, which is than confirmed by doppler-ultrasound. Clinical success is obtained in 87% of the cases and the doppler control is normal in 80% of the cases. We have 9% of minor complications, and no major complication. The number of failures in our study is higher than in Tauber' study, but is the same as those described in the other procedures of treatment of varicocele. On the other hand the surgical procedure is simple and the morbidity is low. [less ▲]

Detailed reference viewed: 129 (5 ULg)
Peer Reviewed
See detailFeeding in darkness alleviates density-dependent growth of juvenile vundu catfish Heterobranchus longifilis (Clariidae)
Baras, E.; Tissier, F.; Westerloppe, L. et al

in Aquatic Living Resources (1998), 11

Detailed reference viewed: 14 (3 ULg)
Peer Reviewed
See detailRésistance bactérienne aux beta-lactamines
Charlier, Paulette ULg; Coyette, Jacques ULg; Dehareng, Dominique ULg et al

in Medecine Sciences : M/S (1998), 14(5), 544-555

Detailed reference viewed: 107 (39 ULg)
Peer Reviewed
See detailMadeline Gins' Helen Keller or Arakawa
Delville, Michel ULg

in The Germ: A Journal of Poetic Research (1998), 2

Detailed reference viewed: 20 (0 ULg)
Peer Reviewed
See detailEléments du diagnostic des parasitoses externes des ruminants
Lonneux, J. F.; Losson, Bertrand ULg

in Point Vétérinaire (1998), 188

Detailed reference viewed: 20 (3 ULg)
Peer Reviewed
See detailPrediction of response to treatment with recombinant human erythropoietin in anaemia associated with cancer.
Beguin, Yves ULg

in Medical Oncology (Northwood, London, England) (1998), 15 Suppl 1

The anaemia associated with cancer can be effectively treated with recombinant human erythropoietin (rHuEpo) in about 60% of the patients. However, the response rate varies according to treatment ... [more ▼]

The anaemia associated with cancer can be effectively treated with recombinant human erythropoietin (rHuEpo) in about 60% of the patients. However, the response rate varies according to treatment modalities as well as the response criteria used. A number of disease- or chemotherapy-related factors determines the probability of response. Several specific mechanisms of anaemia, such as haemolysis, splenomegaly, bleeding, haemodilution, or ineffective erythropoiesis can seriously interfere with response. However, the type of tumor, in particular haematologic versus non-haematologic, is not critical, except in situations of major marrow involvement and limited residual haematopoiesis. Stem cell damage by previous therapy, reflected by low platelet counts or high transfusion needs, will impair response. In addition, marrow suppression by current intensive chemotherapy will also have a negative impact. Besides its intensity, the type of chemotherapy may not be critical, although patients undergoing platinum-based chemotherapy may respond faster than those receiving non-platinum regimens. Complications such as infections, bleeding or nutritional deficiencies may have a major negative impact on outcome. An important response-limiting factor is functional iron deficiency, i.e. an imbalance between iron needs in the erythropoietic marrow and iron supply, which depends on the level of iron stores and its rate of mobilisation. Therefore, oral or preferably intravenous iron supplements should be given when serum ferritin is below 40-100 micrograms/l, reflecting the absence of iron stores, or when the percentage of hypochromic red cells rises above 10%, indicating functional iron deficiency even in the presence of adequate storage iron. Because up to 40% of the patients will not respond to rHuEpo, it is of utmost importance to develop models that could help predict response to rHuEpo and thus select the most appropriate cancer patients for this therapy. Most studies of patients with myeloma or lymphoma have indicated that patients with a low baseline serum Epo level will respond better, but this is not true of patients with solid tumors. Also of considerable interest are early changes of erythropoietic parameters after 2 to 4 weeks of treatment, including increments of serum transferrin receptor (sTfR), reticulocytes and haemoglobin, as well as the persistence of elevated ferritin or Epo levels. Combination of baseline serum Epo and the 2-week increment of sTfR or haemoglobin may provide the best prediction of response. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Peer Reviewed
See detailEstimation of dominance variance in purebred Yorkshire swine
Culbertson, M. S.; Mabry, J. W.; Misztal, I. et al

in Journal of Animal Science (1998), 76(2), 448-451

We used 179,485 Yorkshire reproductive and 239,354 Yorkshire growth records to estimate additive and dominance variances by Method Fraktur R. Estimates were obtained for number born alive (NBA), 21-d ... [more ▼]

We used 179,485 Yorkshire reproductive and 239,354 Yorkshire growth records to estimate additive and dominance variances by Method Fraktur R. Estimates were obtained for number born alive (NBA), 21-d litter weight (LWT), days to 104.5 kg (DAYS), and backfat at 104.5 kg (BF). The single-trait models for NBA and LWT included the fixed effects of contemporary group and regression on inbreeding percentage and the random effects mate within contemporary group, animal permanent environment, animal additive, and parental dominance. The single-trait models for DAYS and BF included the fixed effects of contemporary group, sex, and regression on inbreeding percentage and the random effects litter of birth, dam permanent environment, animal additive, and parental dominance. Final estimates were obtained from six samples for each trait. Regression coefficients for 10% inbreeding were found to be -.23 for NBA, -.52 kg for LWT, 2.1 d for DAYS, and 0 mm for BF. Estimates of additive and dominance variances expressed as a percentage of phenotypic variances were, respectively, 8.8 +/- .5 and 2.2 +/- .7 for NBA, 8.1 +/- 1.1 and 6.3 +/- .9 for LWT, 33.2 +/- .4 and 10.3 +/- 1.5 for DAYS, and 43.6 +/- .9 and 4.8 +/- .7 for BF. The ratio of dominance to additive variances ranged from .78 to .11. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Peer Reviewed
See detailDetection of the lensing galaxy for the double QSO HE 1104-1805
Remy, M.; Claeskens, Jean-François ULg; Surdej, Jean ULg et al

in New Astronomy (1998), 3

High angular resolution ground-based direct imaging (V, R, I_c) of the double QSO HE 1104-1805 has been obtained with the NOT and NTT telescopes. Analysis of these data led to the first detection of the ... [more ▼]

High angular resolution ground-based direct imaging (V, R, I_c) of the double QSO HE 1104-1805 has been obtained with the NOT and NTT telescopes. Analysis of these data led to the first detection of the lensing galaxy. Direct imaging of HE 1104-1805 has subsequently been carried out with the Planetary Camera (WFPC2) through the F555W (nearly Johnson V) and F814W (nearly Kron-Cousins I_c) filters onboard HST. These images confirm the presence of the deflector between the two lensed quasar components (A & B). Direct imaging of this system in the near infrared (IR) at 2.2 mu-m (K'), with IRAC-2b at the Cassegrain focus of the ESO/MPI 2.2 m telescope, indicates that the additional component is indeed a very red extended object with magnitude K ~= 16.5. We present deconvolutions of the HST and IR images using the 2-channel PLUCY method. From the HST observations, we also report very accurate relative positions and brightnesses of the QSO components. By comparison between the ground-based and the HST observations, from February-March 1994 to November 1995, we possibly detect the fading of component A by ~ 0.3 magnitudes in the optical and a corresponding fading of B by about half this value. The observed monotonic decrease of the magnitude difference between B and A as a function of wavelength is consistent with a partial amplification of the A component by microlensing. Evolutionary models for galaxies show that, in order to produce the observed colour indices V - I_c > 2 and 4 < I_c - K < 4.5, the galaxy is likely to be of elliptical type with a redshift 0.95 < z < 1.4. This range is consistent with the redshift z=1.32 measured from the absorption lines of metallic species in the spectra of the quasar components. However, other values for the redshift of the lens inside this range cannot be excluded. This galaxy would presently be among the most distant known gravitational lenses. Several theoretical models are found to fit the observations. The simplest one is a singular isothermal sphere (SIS) lens immersed in an external shear with gamma=0.123. The derived mass-to-light ratio (11 h_50 M_Sun/L_Sun) for the galaxy is large but does not imply an excess of dark matter with respect to other well known lensing galaxies. [less ▲]

Detailed reference viewed: 95 (8 ULg)
Peer Reviewed
See detailSurgical management of amiodarone-associated thyrotoxicosis: too risky or too effective?
Hamoir, Etienne ULg; Meurisse, Michel ULg; Defechereux, Thierry ULg et al

in World Journal of Surgery (1998), 22(6), 537-42542-3

Amiodarone-associated thyrotoxicosis, often clinically mild and resolutive after amiodarone discontinuation or under medical therapy, is sometimes drug unresponsive and not uncommonly follows a dramatic ... [more ▼]

Amiodarone-associated thyrotoxicosis, often clinically mild and resolutive after amiodarone discontinuation or under medical therapy, is sometimes drug unresponsive and not uncommonly follows a dramatic, even fatal course. Therefore, we considered a surgical solution in 15 severely amiodarone-associated thyrotoxic patients. Twelve men and three women (mean age 68 years, range 50-84 years) underwent radical thyroidectomy for clinical and biologically proved amiodarone-associated thyrotoxicosis. In six surgery was the first-line therapeutic option. In the other nine thyroidectomy seemed unavoidable considering the unresponsiveness to medical therapy and rapid deterioration of the patients' clinical condition, with life-threatening cardiac failure in three. In every patient surgery was conducted without immediate or delayed complications. Total thyroidectomy proved uniformly, definitively, and rapidly effective in controlling thyrotoxicosis in all patients, with a spectacular reversal of cardiac failure in the three most critical cases. Surgery was beneficial to our 15 patients and undoubtedly life-saving in the three most worrying cases. These results suggest that thyroidectomy should be more liberally regarded as an interesting alternative to conventional, but unpredictably effective, medical therapies. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Peer Reviewed
See detailTwo photon decay of the glueball and scalar isosclar mesons in a scaled NJL model
Jaminon, Martine ULg; Van den Bossche, Bruno

in Nuclear Physics A (1998), 636

We use a modified version of the Nambu-Jona-Lasinio (NJL) model which implements the QCD trace anomaly to calculate the two photon decay width of the glueball (f0(1500)) and of the two scalar mesons (f0 ... [more ▼]

We use a modified version of the Nambu-Jona-Lasinio (NJL) model which implements the QCD trace anomaly to calculate the two photon decay width of the glueball (f0(1500)) and of the two scalar mesons (f0(1370), fJ=0(1710)) to which it is mixed. We investigate the effect of the mixing over the coupling constants of the f0 states to the quarks and over the widths. We show that mass and phase space effects are crucial, at least in the NJL model, in determining the relative strength of the 2γ widths. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Peer Reviewed
See detailCellular and molecular aspects of thymic T-cell education to neuroendocrine self principles: implications in autoimmunity
Geenen, Vincent ULg; Martens, Henri ULg; Kecha, Ouafae et al

in Annals of the New York Academy of Sciences (1998), 840

Detailed reference viewed: 9 (1 ULg)
Peer Reviewed
See detailThe prevalence of Clostridium perfringens in the horse
Griffiths, N. J.; Walton, J. R.; Edwards, G. B. et al

in Rev Med Microbiol (1998), 9

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailPit-1 polymorphisms and milk production parameters in Italian-Frisian bulls
Parmentier, isabelle; Gengler, Nicolas ULg; Mortiaux, Frédéric et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 3

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailLa Convention de Bruxelles
Boularbah, Hakim ULg; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (1998)

Detailed reference viewed: 11 (2 ULg)
Peer Reviewed
See detailProtein composition and agglomeration tendency of gluten isolated from European wheats (Triticum aestivum L.) in a batter system
Roels, S. P.; Sindic, Marianne ULg; Deroanne, Claude et al

in Journal of Agricultural and Food Chemistry (1998), 46(4), 1344-1349

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons ... [more ▼]

Pilot scale isolation of gluten (with recovery of gluten on 400, 250, and 125 mu sieves) from flour prepared from six European wheat varieties (Apollo, Slejpner, Sperber, Camp Remy, Minaret, and Soissons) resulted in, on average, gluten yields of 9.6% (4.7-13.2% range). Gluten protein recoveries averaged 63.0% (34.5-85.7% range). Gluten yields and gluten protein recoveries were linearly related and increased when mixing times and baking absorptions required for optimal dough development of the parent flours increased, indicating that there is a relationship between the agglomeration properties of gluten proteins in a batter system and the optimal technological conditions necessary for processing the flours in breadmaking. The Osborne protein fractions in the gluten fractions were determined. The 0.05 M acetic acid soluble (glutenin) fraction was quantitatively the most important fraction (40-46% of gluten Kjeldahl nitrogen) while comparable levels of 70% ethanol soluble (gliadins) and 0.05 M acetic acid insoluble (residue protein) were found (17.9-22.3% of gluten Kjeldahl nitrogen and 22.0-29.0% of gluten Kjeldahl nitrogen for gliadins and residue protein, respectively). With decreasing pore size of the sieves, the level of glutenin in the gluten decreased while the level of gliadins increased. This indicates that, in gluten with good agglomeration properties, the level of glutenins is high and that the agglomeration properties of such proteins (i.e. their tendency to aggregate) strongly determines the agglomeration behavior of the gluten as a whole. [less ▲]

Detailed reference viewed: 45 (0 ULg)
Full Text
Peer Reviewed
See detailPrenatal diagnosis of pyruvate carboxylase defiency by direct measurement of catalytic activity on chorionic villi samples
Van Coster; Janssens, S.; Misson, Jean-Paul ULg et al

in Prenatal Diagnosis (1998), 18

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailTrophic relationships within intertidal communities of the Brittany coast: a stable carbon isotope analysis
Dauby, Patrick ULg; Khomsi, Ahmid; Bouquegneau, Jean-Marie ULg

in Journal of Coastal Research (1998), 14

Detailed reference viewed: 16 (2 ULg)
Full Text
See detailLe monticule frasnien de la carrière du Nord à Frasnes (Belgique): sédimentologie, stratigraphie séquentielle et coraux
Boulvain, Frédéric ULg; Coen-Aubert, M.

in Professional Paper Belgian Geological Survey (1998), 285

Detailed reference viewed: 64 (10 ULg)
Full Text
Peer Reviewed
See detailThe Current N-15-Leucine Infusion Technique Is Not Suitable For Quantitative Measurements Of Ileal Endogenous Amino Acid Flows In Pigs
Leterme, Pascal; Seve, Bernard; Thewis, André ULg

in Journal of Nutrition (1998), 128(11), 1961-1968

The current 15N-leucine infusion technique may overestimate the ileal endogenous nitrogen losses in pigs. To determine the reason, we infused four cannulated pigs intravenously, fed them a pea-based diet ... [more ▼]

The current 15N-leucine infusion technique may overestimate the ileal endogenous nitrogen losses in pigs. To determine the reason, we infused four cannulated pigs intravenously, fed them a pea-based diet with 15N-leucine, and examined some methodological variables. Neither the blood sampling time nor the choice of precursor pool (total N or amino acid N of deproteinized plasma) or the method of estimation of the isotopic equilibrium level significantly affected the results. On the other hand, the 15N-enrichment of purified mucin, isolated from ileal digesta, was higher than that of the plasma amino acid pool (0.114 vs. 0.077 atom % excess). The endogenous proportion of the labeled amino acids (Ala, Gly, Ile, Leu and Val) in the ileal digesta ranged from 23 (Leu) to 74% (Ala), compared with 70% for total N. The low value of leucine was ascribed to the constant marker infusion condition. In pigs infused with 13C-leucine, a similar endogenous proportion was obtained for lumenal leucine with 13C-leucine and 15N-leucine infusion. However, the 13C-enrichment of the leucine bound to mucin was markedly lower than that of plasma leucine (38%). The endogenous amino acid flows were also estimated by combining the ileal N flow measured with 15N and the endogenous amino acid profile obtained by means of an N-free diet. They were different from those obtained with the 15N-amino acid dilution technique. We conclude that the precursor pool currently used (plasma total N or total a-amino acid N pools) is a poor indicator of the enrichment of the secretions and that the infusion of one labeled amino acid is not sufficient to extend the method at the amino acid level. [less ▲]

Detailed reference viewed: 22 (0 ULg)
Peer Reviewed
See detailA new time domain to estimate windkessel parameters of pulmonary circulation
LAMBERMONT, Bernard ULg; GERARDP; POTTY, P et al

in American Journal of Respiratory & Critical Care Medicine (1998), 157

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailSample size for collecting seeds in germplasm conservation: the case of the Lima bean (Phaseolus lunatus L.)
Bi, Irié Zoro; Maquet, A.; Degreef, J. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1998), 97(1-2),

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailIsotopic constraints on the Cenozoic evolution of the carbon cycle
François, Louis ULg; Godderis, Y.

in Chemical Geology (1998), 145(3-4), 177-212

In the last few years, several models have been built to explore the Cenozoic evolution of the carbon and strontium cycles. Of particular interest is the study of the impact on the carbon cycle of major ... [more ▼]

In the last few years, several models have been built to explore the Cenozoic evolution of the carbon and strontium cycles. Of particular interest is the study of the impact on the carbon cycle of major mountain uplifts such as the Himalayan orogeny. To explain the Cenozoic increase in the measured seawater strontium isotopic ratio, it was recently proposed that the Himalyan uplift could be responsible for an enhanced consumption of atmospheric CO2 by continental silicate weathering. Here, a new model of the carbon cycle evolution over Cenozoic times is presented. It calculates the various fluxes involved in the organic and inorganic components of the carbon cycle from the seawater delta C-13, the biological isotopic fractionation in the ocean and the seafloor spreading rate. The model equilibrates the budgets of the carbon and alkalinity cycles on the million year timescale, assuming as many previous investigators that the system remains close to equilibrium. The validity of this equilibrium approximation is examined critically. Various sensitivity experiments are performed in order to test the impact of the model parameters on the results. The calculated history of the carbonate deposition rate is consistent with the available reconstruction. The continental silicate weathering rate calculated by the model appears to be widely insensitive to the model parameters, showing three distinct evolutions over the Cenozoic. The model indeed suggests a time of relative constancy of the silicate weathering flux before 40 Ma, followed by a period of slow decrease until 15 Ma and finally a marked increase up to the present. In a progressively cooler world, this evolution may be interpreted as a change from a 'chemically' controlled to a 'physically' controlled weathering regime. The evolution of continental silicate weathering thus partly appears decoupled from the increase in the observed seawater strontium isotopic ratio. For this reason, the evolution of the calculated riverine Sr-87/ Sr-86 ratio shows a strong increase over the Cenozoic, from about 0.710 to 0.712. However, this increase may largely be reduced by considering the recycling of a pelagic carbonate reservoir increasing over the Cenozoic or by assuming that seafloor basalt weathering is a CO2- or climate-dependent process. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

Detailed reference viewed: 23 (1 ULg)
Peer Reviewed
See detailCharacterizations by automorphism groups of some rank 3 buildings - I. Some properties of half strongly-transitive triangle buildings
Van Maldeghem, H.; Van Steen, Kristel ULg

in Geometriae Dedicata (1998), 73(2), 119-142

In a sequence of papers, we will show that the existence of a (half) strongly-transitive automorphism group acting on a locally finite triangle building Delta forces Delta to be one of the examples ... [more ▼]

In a sequence of papers, we will show that the existence of a (half) strongly-transitive automorphism group acting on a locally finite triangle building Delta forces Delta to be one of the examples arising from PSL3(K) for a locally finite local skewfield K. Furthermore, we introduce some Moufang-like conditions in affine buildings of rank 3, and characterize those examples arising from algebraic,classical or mixed type groups over a local field. In particular, we characterize the p-adic-like affine rank 3 buildings by a certain p-adic Moufang condition, and show that such a condition has zero probability to survive in hyperbolic rank 3 buildings. This shows that a construction of hyperbolic buildings as analogues of p-adic affine buildings is very unlikely to exist. Mathematics Subject Classifications (1991): 51E24, 51C05. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailEffect of seasonal acclimatization on the expression of the carp transcription factor Pit-1
Kausel, G.; Vera, M. I.; Figueroa, J. et al

in Biochemistry and Molecular Biology International (1998), 45(5), 813-21

We isolated a clone comprising four exons of the carp Pit-1 gene. Using synthetic oligonucleotide probes derived from the carp Pit-1 sequence Pit-1 expression was assessed by in situ hybridization in ... [more ▼]

We isolated a clone comprising four exons of the carp Pit-1 gene. Using synthetic oligonucleotide probes derived from the carp Pit-1 sequence Pit-1 expression was assessed by in situ hybridization in pituitary sections from summer- and winter-acclimatized carp. Semiquantitative analyses of the hybridization signals revealed a significant higher Pit-1 expression in the proximal pars distalis (PPD) and pars intermedia (PI) of the pituitary glands from summer-acclimatized carp, compared to the winter-acclimatized fish. In both adaptive states, relative to the PPD and PI, only a basal Pit-1 expression was detected in the rostral pars distalis. Thus, during seasonal acclimatization of an eurythermal fish, Pit-1 seems to be involved in the mechanisms that underlie the compensatory response. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
See detailAnalyse de l'enseignement des activités physiques et sportives dans la perspective d'un traitement différencié des élèves de l'enseignement primaire
Piéron, Maurice ULg; Ledent, Maryse; Delfosse, Catherine et al

in Revue de l'Education Physique (1998), 38(1), 11-24

Afin de recueillir une image valide tu traitement différencié des élèves dans des leçons d'éducation physique, il est primordial de proposer une approche multidimensionnelle, prenant comme cible les ... [more ▼]

Afin de recueillir une image valide tu traitement différencié des élèves dans des leçons d'éducation physique, il est primordial de proposer une approche multidimensionnelle, prenant comme cible les différents acteurs du processus édagogique, à la fois les enseignants et les élèves. Par ailleurs, deux types d'informations devraient être récoltés afin de rendre compte de la réalité de la relation pédagogique: celles qui concernent les comportements et actions concrètes et celles relevant des valeurs, attitudes, perceptions et mécanismes de prise de décision. Les premières reposent sur l'observation alors que les secondes exigent l'interrogation des sujets. [less ▲]

Detailed reference viewed: 136 (3 ULg)
Full Text
Peer Reviewed
See detailVersatile and controlled synthesis of star and branched macromolecules by dentritic initiation
Trollsas, Michaël; Hedrick, James L.; Mecerreyes, David et al

in Macromolecules (1997), 30(26), 8508-8511

Detailed reference viewed: 25 (5 ULg)
Full Text
Peer Reviewed
See detailAngiogenesis by Fibroblast Growth Factor 4 Is Mediated through an Autocrine Up-regulation of Vascular Endothelial Growth Factor Expression
Deroanne, Christophe ULg; Hajitou, Amin; Calberg-Bacq, Claire-M. et al

in Cancer Research (1997), 57

The infection of normal mouse mammary EF43 cells by a retroviral vector carrying either Fgf-3 (EF43.Fgf-3) or Fgf-4 (EF43.Fgf-4) cDNA resulted in the transformation of cells displaying different ... [more ▼]

The infection of normal mouse mammary EF43 cells by a retroviral vector carrying either Fgf-3 (EF43.Fgf-3) or Fgf-4 (EF43.Fgf-4) cDNA resulted in the transformation of cells displaying different tumorigenic potentials in nude mice (A. Hajitou and C-M. Calberg-Bacq, Int. J. Cancer, 63: 702-709, 1995). EF43.Fgf-4 produced rapidly developing tumors at all sites of inoculation, whereas EF43.Fgf-3 produced slowly growing tumors only in the mammary fat pad. Cells infected with the vector carrying the selection gene alone (EF43.C) were not tumorigenic. The angiogenic properties of these cells were tested in an in vitro angiogenesis model using human umbilical vein endothelial cells (HUVECs) cultured at the surface of a type I collagen gel and their capacity to form tube-like structures on invasion of the gel. Only the conditioned medium (CM) of EF43.Fgf-4 induced an angiogenic morphotype in HUVECs. In parallel, the mRNA expression of matrix metalloproteinase 1 and c-ETS-1 was increased in the HUVECs displaying a differentiated phenotype, whereas the tissue inhibitor of matrix metalloproteinase 1 mRNA level was decreased. Recombinant human fibroblast growth factor 4 (FGF-4) did not induce an angiogenic phenotype in HUVECs by itself. By Western blot analysis, a high expression of vascular endothelial growth factor (VEGF) was detected in the EF43.Fgf-4 CM. This result was confirmed by Northern blot analysis of total RNA extracted from the three cell types; the steady-state level of VEGF mRNA was low and equivalent in EF43.C and EF43.Fgf-3, whereas it was strongly increased in EF43.Fgf-4. Culturing EF43 cells carrying only the selection gene with increasing concentrations of recombinant human FGF-4 resulted in a dose-dependent stimulation of VEGF. The induction of the angiogenic morphotype and the parallel modulations of the biosynthetic phenotype in HUVECs were completely suppressed by adding a neutralizing antibody directed against VEGF to EF43.Fgf-4 CM. Furthermore, inhibition of protein kinase C by bisindoylmaleimide suppressed the angiogenic phenotype induced by the CM of EF43.Fgf-4. Our results point to an indirect angiogenic activity of FGF-4 through the autocrine induction of VEGF secretion by EF43.Fgf-4 cells, an original signaling pathway that might be significant in tumor progression and metastasis. [less ▲]

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailAlteration of Interendothelial Adherens Junctions Following Tumor Cell-Endothelial Cell Interaction in Vitro
Lewalle, J. M.; Bajou, Khalid ULg; Desreux, Joëlle ULg et al

in Experimental Cell Research (1997), 237(2), 347-56

The integrity of the vascular endothelium is mainly dependent upon the organization of interendothelial adherens junctions (AJ). These junctions are formed by the homotypic interaction of a transmembrane ... [more ▼]

The integrity of the vascular endothelium is mainly dependent upon the organization of interendothelial adherens junctions (AJ). These junctions are formed by the homotypic interaction of a transmembrane protein, vascular endothelial cadherin (VE-cadherin), which is complexed to an intracellular protein network including alpha-, beta-, and gamma-catenin. Additional proteins such as vinculin and alpha-actinin have been suggested to link the VE-cadherin/catenin complex to the actin-based cytoskeleton. During the process of hematogenous metastasis, circulating tumor cells must disrupt these intercellular junctions in order to extravasate. In the present study, we have investigated the influence of tumor cell-endothelial cell interaction upon interendothelial AJ. We show that human breast adenocarcinoma cells (MCF-7), but not normal human mammary epithelial cells, induce a rapid endothelial cell (EC) dissociation which correlates with the loss of VE-cadherin expression at the site of tumor cell-EC contact and with profound changes in vinculin distribution and organization. This process could not be inhibited by metalloproteinase nor serine protease inhibitors. Immunoprecipitations and Western blot analysis demonstrate that the overall expression of VE-cadherin and vinculin as well as the composition of the VE-cadherin/catenins complex are not affected by tumor cells while the tyrosine phosphorylation status of proteins within the complex is significantly altered. Our data suggest that tumor cells modulate AJ protein distribution and phosphorylation in EC and may, thereby, facilitate EC dissociation. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailSynergism for the improvement of tensile strength in block copolymers of polystyrene and poly(n-butyl methacrylate)
Weidisch, R.; Michler, G. H.; Arnold, M. et al

in Macromolecules (1997), 30(25), 8078-8080

Detailed reference viewed: 13 (1 ULg)
Peer Reviewed
See detailPrivate Multiple Congenital Anomaly Syndromes May Result from Unbalanced Subtle Translocations: T(2q;4p) Explains the Lambotte Syndrome
Herens, Christian ULg; Jamar, Mauricette ULg; Alvarez Gonzalez, Maria-Luz ULg et al

in American Journal of Medical Genetics (1997), 73(2), 127-31

In 1990, Lambotte syndrome was reported as an apparently autosomal recessive multiple congenital anomaly/mental retardation (MCA/MR) syndrome observed in 4 of 12 sibs from a probably consanguineous mating ... [more ▼]

In 1990, Lambotte syndrome was reported as an apparently autosomal recessive multiple congenital anomaly/mental retardation (MCA/MR) syndrome observed in 4 of 12 sibs from a probably consanguineous mating [Verloes et al., Am J Med Genet 1990; 37:119-123]. Major manifestations included intrauterine growth retardation (IUGR), microcephaly, large soft pinnae, hypertelorism, beaked nose, and extremely severe neurologic impairment, with holoprosencephaly in one instance. After the observation of a further affected child born of one unaffected sister, in situ hybridization analysis and chromosome painting techniques demonstrated a subtle t(2;4)(q37.1; p16.2) translocation in the mother, suggesting a combination of 2q/4p trisomy/monosomy in all of the affected children of the family. Many private sporadic or recurrent MCA/MR syndromes maybe due to similar symmetric translocations, undetectable by conventional banding techniques. [less ▲]

Detailed reference viewed: 20 (1 ULg)
See detailLes constellations (V).
Renson, Pierre ULg

in Ciel et Terre (1997), 113

Not Available

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailSpectroscopic analysis of the Alpha Centauri system
Neuforge-Verheecke, C.; Magain, Pierre ULg

in Astronomy and Astrophysics (1997), 328

A detailed spectroscopic analysis of the two components of the binary system alpha Centauri has been carried out on the basis of extensive high resolution and high signal-to-noise spectra. The ... [more ▼]

A detailed spectroscopic analysis of the two components of the binary system alpha Centauri has been carried out on the basis of extensive high resolution and high signal-to-noise spectra. The temperatures of the stars have been determined from the Fei excitation equilibrium and checked from the H_alpha line wings. The abundances of 17 elements have been obtained and indicate a general overabundance of 0.24 dex relative to the Sun, with no significant difference between the two stars. All elements analysed, from CNO to the iron peak, show basically the same overabundance. Only nickel seems to be significantly more overabundant, while the neutron capture elements appear less enhanced. Based on observations carried out at the European Southern Observatory (La Silla, Chile) [less ▲]

Detailed reference viewed: 25 (1 ULg)
Peer Reviewed
See detailDistinct Signal Transduction Pathways Mediate Nuclear Factor-Kappab Induction by Il-1beta in Epithelial and Lymphoid Cells
Bonizzi, Giuseppina; Piette, Jacques ULg; Merville, Marie-Paule ULg et al

in Journal of Immunology (1997), 159(11), 5264-72

We previously demonstrated that IL-1beta-mediated induction of the nuclear factor-kappaB (NF-kappaB) transcription factor proceeds through the production of reactive oxygen intermediates in lymphoid cells ... [more ▼]

We previously demonstrated that IL-1beta-mediated induction of the nuclear factor-kappaB (NF-kappaB) transcription factor proceeds through the production of reactive oxygen intermediates in lymphoid cells, while it occurs independently of any oxidative stress in epithelial transformed cells. Indeed, inhibition of receptor internalization as well as NH4Cl and chloroquine blocked IL-1beta-mediated induction of NF-kappaB in OVCAR-3 and in other epithelial cell lines but not in lymphoid cells, indicating that distinct pathways are involved. Conversely, while we observed phospholipase A2 activity in both cell types following IL-1beta stimulation, specific inhibitors of this enzyme inhibited NF-kappaB induction only in lymphoid cells. Moreover, expression of the 5-lipoxygenase (5-LOX) enzyme was not detected in epithelial cells, and inhibition of this enzyme blocked NF-kappaB induction by IL-1beta only in lymphoid cells. This study thus indicates that the activation of NF-kappaB following IL-1beta treatment involves the activation of phospholipase A2 and 5-LOX and the production of reactive oxygen intermediates (ROIs) in lymphoid cells, while in epithelial cells, another pathway predominates and could involve the acid sphingomyelinase. Moreover, arachidonic acid could induce NF-kappaB in epithelial and lymphoid cells, but this activation involved the 5-LOX enzyme and the production of ROIs only in lymphoid cells. The inefficiency of the ROI pathway in epithelial cells is probably the consequence of both low ROI production due to undetectable expression of 5-LOX and rapid degradation of hydrogen peroxide due to high catalase activity. [less ▲]

Detailed reference viewed: 30 (4 ULg)
Full Text
Peer Reviewed
See detailESO & NOT photometric monitoring of the Cloverleaf quasar
Ostensen, R.; Remy, M.; Lindblad, P. O. et al

in Astronomy and Astrophysics. Supplement Series (1997), 126

The Cloverleaf quasar, H1413+117, has been photometrically monitored at ESO (La Silla, Chile) and with the NOT (La Palma, Spain) during the period 1987--1994. All good quality CCD frames have been ... [more ▼]

The Cloverleaf quasar, H1413+117, has been photometrically monitored at ESO (La Silla, Chile) and with the NOT (La Palma, Spain) during the period 1987--1994. All good quality CCD frames have been successfully analysed using two independent methods (i.e. an automatic image decomposition technique and an interactive CLEAN algorithm). The photometric results from the two methods are found to be very similar, and they show that the four lensed QSO images vary significantly in brightness (by up to 0.45 mag), nearly in parallel. The lightcurve of the $D$ component presents some slight departures from the general trend which are very likely caused by micro-lensing effects. Upper limits, at the 99% confidence level, of 150 days on the absolute value for the time delays between the photometric lightcurves of this quadruply imaged variable QSO, are derived. This is unfortunately too large to constrain the lens model but there is little doubt that a better sampling of the lightcurves should allow to accurately derive these time delays. Pending a direct detection of the lensing galaxy (position and redshift), this system thus constitutes another good candidate for a direct and independent determination of the Hubble parameter. Based on observations collected at the European Southern Observatory (La Silla, Chile) and with the Nordic Optical Telescope (La Palma, Spain). Table 1. Logbook for the ESO and NOT observations together with photometric results for the Cloverleaf quasar. This long table can be accessed on the WWW at the URL address: http://vela.astro.ulg.ac.be/grav_lens/glp_homepage.html} [less ▲]

Detailed reference viewed: 46 (6 ULg)
Peer Reviewed
See detailCoherent and random sequences in financial fluctuations
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physica A: Statistical Mechanics and its Applications (1997), 246(3-4), 454-459

The detrended fluctuation analysis (DFA) is used to sort out temporal correlations in financial data. Its usefulness for the investigations of long-range power-law correlations in economic sequences is ... [more ▼]

The detrended fluctuation analysis (DFA) is used to sort out temporal correlations in financial data. Its usefulness for the investigations of long-range power-law correlations in economic sequences is shown. Our findings of persistent and antipersistent sequences are surprisingly similar to those for DNA sequences which appeared as a mosaic of coding and non-coding patches. [less ▲]

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailDifunctional anionic initiator based on 1.3-diisopropenylbenzene. 5. Effect of polar additives and initiator seeding on the synthesis of poly(styrene-b-butadiene-b-styrene) copolymer
Yu, Y. S.; Dubois, Philippe ULg; Teyssié, Philippe et al

in Macromolecules (1997), 30(24), 7356-7362

The initiation of butadiene and styrene polymerization by a pure hydrocarbon soluble difunctional organolithium, 1,3-bis(1-lithio-1,3,3‘-trimethylbutyl)benzene, has been studied in a hydrocarbon solvent ... [more ▼]

The initiation of butadiene and styrene polymerization by a pure hydrocarbon soluble difunctional organolithium, 1,3-bis(1-lithio-1,3,3‘-trimethylbutyl)benzene, has been studied in a hydrocarbon solvent. The initiation occurs in such a way that part of the diadduct remains unreacted. When a second monomer feed along with tetrahydrofuran (THF) is added to the living chains, the residual diadduct is activated to the point where novel chains are formed. Weakly polar additives such as lithium alkoxides and aromatic ether can prevent part of the initiator from being inactive, although these additives are not effective enough to initiate the controlled synthesis of poly(styrene-b-butadiene-b-styrene) (SBS) triblock copolymers. The seeding of the initiator which consists of butadiene oligomerization in the presence of anisole and tBuOLi in cyclohexane, has proved to be very efficient in providing SBS containing 85% 1,4-microstructure polybutadiene (PBD) and with high mechanical properties, e.g., ultimate tensile strength higher than 30 MPa and elongation at a break of 1000%. [less ▲]

Detailed reference viewed: 26 (4 ULg)
Full Text
Peer Reviewed
See detailSmall-angle neutron scattering studies of low polarity telechelic ionomer solutions. 2. Single chain scattering
Karayianni, Eleni; Jérôme, Robert ULg; Cooper, Stuart L

in Macromolecules (1997), 30(24), 7444-7455

A direct probe of the single chain conformation in associating low polarity model telechelic ionomer solutions has been obtained using small-angle neutron scattering. A contrast matching technique was ... [more ▼]

A direct probe of the single chain conformation in associating low polarity model telechelic ionomer solutions has been obtained using small-angle neutron scattering. A contrast matching technique was employed utilizing a solution of hydrogenated and deuterated ionomer chains in a mixture of labeled and unlabeled solvent molecules. The scattering data at all concentrations and ionic levels examined show an excellent fit to the wormlike chain model. Single chain scattering patterns were obtained for two sodium-neutralized carboxy−telechelic polystyrene ionomers that differ by a factor of 2 in their molecular weight, in a concentration range from the dilute to the concentrated solution regime. The single chain dimensions were found to be influenced by both the ionic interactions and the extent of association. Both ionomer systems showed a contraction of the chain dimensions in the dilute solution regime which is more pronounced for the lower molecular weight telechelic ionomer. As concentration increases, the single chain dimensions increase until they reach a plateau value in the concentrated solution regime. This plateau value is very close to the chain dimensions of the ionomer in the bulk, as was found from a previous SANS study on similar ionomer systems. This plateau value chain dimension is also the same as the unperturbed dimension of the nonionic parent polymer in the bulk. The effect of concentration on the ionomer chain dimensions is attributed to the influence of ionic interactions as the nonionic form of the material shows larger chain dimensions in the concentration regime studied. These results indicate that intramolecular interactions with the formation of self loops prevail in the dilute solution regime. Intermolecular interactions with ionic groups connecting to different chains prevail in the concentrated solution regime, as evidenced by an extension of the chain dimensions. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailAnionic polymerization of methacrylate monomers initiated by lithium dialkylamides
Antoun, Sayed; Teyssié, Philippe; Jérôme, Robert ULg

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(17), 3637-3544

The anionic polymerization of methacrylate monomers has been investigated with lithium dialkylamides as initiators in THF and toluene, respectively. Theoretical arguments and previous studies of mixed ... [more ▼]

The anionic polymerization of methacrylate monomers has been investigated with lithium dialkylamides as initiators in THF and toluene, respectively. Theoretical arguments and previous studies of mixed aggregates of lithiated organic compounds support the complexity of these systems. Lithium diisopropylamide (LDA) shows the highest initiation efficiency (e.g., f = 75% in THF at -78°C). Interestingly enough, lithium chloride has a remarkable beneficial effect on the methacrylates polymerization in THF at -78°C, due to the formation of 1 : 1 mixed dimer with LDA, which promotes a well-controlled anionic polymerization (Mw/Mn = 1.05) with a high initiation efficiency (94%). The less bulky lithium-diethylamide (LDEA) is much less efficient (f = 26%), essentially as a result of some associated dormant species and side reactions on the carbonyl group of MMA. Although various types of ligands have been screened, no remarkable improvement of LDEA efficiency has been observed. Lithium bis(trimethylsilyl)amide (LTMSA) has also been used to increase the steric hindrance of the initiator. This compound is, however, unable to initiate the methacrylates polymerization, more likely because of a too low basicity and a too strong Li - N bond. © 1997 John Wiley [less ▲]

Detailed reference viewed: 40 (1 ULg)
See detailMAVIS STAPLES
Sacré, Robert ULg

in Soul Bag (1997), (145), 75

hoto : Mavis STAPLES , Peer , juillet 1992

Detailed reference viewed: 23 (0 ULg)
Full Text
Peer Reviewed
See detailSmall-angle X-ray scattering and small-angle neutron scattering studies of liquid-crystalline halato(semi)telechelic polymers
Sobry, Roger ULg; Van den Bossche, Guy ULg; Fontaine, Frédéric et al

in Journal of Applied Crystallography (1997), 30(6), 1075-1083

Model liquid-crystalline ionomers have been synthesized, which consist of low molecular weight (700-49000) linear ω- and α,ω-sodium sulfonate- and carboxylato-poly(styrenes or isoprenes) selectively end ... [more ▼]

Model liquid-crystalline ionomers have been synthesized, which consist of low molecular weight (700-49000) linear ω- and α,ω-sodium sulfonate- and carboxylato-poly(styrenes or isoprenes) selectively end-capped at one or both end(s) with an ionic mesogenic group. These compounds are referred to as liquid-crystalline halato(semi)telechelic polymers [LC H(S)TPs] A combination of small-angle X-ray scattering and small-angle neutron scattering studies on these LC H(S)TPs clearly shows the usual ionic peak related to interparticle interference between the ionic aggregates and a peak which can be related to the organization of a smectic mesophase. This mesogenic peak is generally masked by the foot of the broad ionic peak. The ionic peak Bragg spacing is much larger in the LC H(S)TP than in the H(S)TP precursor; This increased interaggregate distance results from the hindrance due to the mesogenic organization and from the restricted mobility experienced by the chains closely attached to the mesogen layers. As a rule, the lower the glass transition temperature of the polymeric matrix, the better the definition of the ionic peak, The ionic peak is well defined as long as the temperature is lower than the temperature of transition from solid to smectic phase (32.3 K). At higher temperatures, the ionic peak intensity decreases with increasing temperature. [less ▲]

Detailed reference viewed: 33 (3 ULg)
Full Text
Peer Reviewed
See detailEditorial: Pour une anthropologie du regard
Strivay, Lucienne ULg; Gossiaux, Pol-Pierre ULg

in Voir (1997), 15

Detailed reference viewed: 51 (2 ULg)
Peer Reviewed
See detailResilience, desistance and delinquent career of adolescent offenders
Born, Michel ULg; Chevalier, V.; Humblet, I.

in Journal of Adolescence (1997), 20(6), 679-694

This study examines resilience and desistance from delinquent behaviours and attempts to identify factors which predict persistent or increased or decreased delinquency between adolescence and early ... [more ▼]

This study examines resilience and desistance from delinquent behaviours and attempts to identify factors which predict persistent or increased or decreased delinquency between adolescence and early childhood. A sample of 363 young people was obtained from the population of five public institutions in 1987 and 1992. Their delinquent trajectories were described on the basis of legal records. These suggested that resilience is a rare phenomenon and is associated with stable relationships, absence of diagnostic label and good adaptation to the institution. Two axes were identified which can be used to describe the population, the family background and the psychological characteristics of the individual. Information which predicted desistance from a delinquent career was identified by means of a stepwise multiple regression. Analyses were conducted separately for each age group to take account of differences in time after the placement. The results indicated that there are important age-related differences in the characteristics which influence desistance or risk. They also show length of stay in an institution to be a predictor. Desistance from further delinquency seems to depend on the time spent in the residential environment associated with an increase of guilt, an improvement of self-image and of attachment to one or more other people. [less ▲]

Detailed reference viewed: 147 (15 ULg)
Peer Reviewed
See detailMethodology of high speed railway network planning
Marchal, Jean ULg; Han, Baoming

in Proceedings of the Second Conference of Hongkong Society for Transportation Studies HKSTS (1997)

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailIntensity Dependence of the Cortical Auditory Evoked Potentials as a Surrogate Marker of Central Nervous System Serotonin Transmission in Man: Demonstration of a Central Effect for the 5ht1b/1d Agonist Zolmitriptan (311c90, Zomig)
Proietti-Cecchini, A.; Afra, J.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1997), 17(8), 849-54799

As shown in animal studies, 5HT1B/D agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for their antimigraine effect. To demonstrate a possible central nervous ... [more ▼]

As shown in animal studies, 5HT1B/D agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for their antimigraine effect. To demonstrate a possible central nervous system (CNS) action of these compounds in man we studied their effect on the intensity dependence of the cortical auditory evoked potentials (IDAPs), thought to be inversely related to central serotonergic transmission. An amplitude/stimulus intensity function (ASF) slope was computed in healthy volunteers and migraine patients between attacks before and 2 h after oral 311C90 (zolmitriptan "Zomig") 10 mg (n=14), 311C90 5 mg (n=7), sumatriptan 100 mg (n=14), dexfenfluramine 15 mg (n=4), lorazepam 1.25 mg (n=4) and placebo (n=14). 311C90 10 mg and, to a lesser degree, 5 mg significantly increased the mean ASF slope (p=0.007 and 0.05 vs placebo). There was a significant positive correlation between plasma levels of 311C90 and ASF slope changes. Sumatriptan and lorazepam had little effect, but dexfenfluramine produced a significant ASF slope decrease. 311C90 is able to modify a CNS activity that is modulated by serotonin, i.e. the IDAP. This effect is probably the consequence of its superior lipophilicity compared to sumatriptan and of activation of prejunctional 5HT1B/D autoreceptors, which lowers central serotonin release and thus the preactivation level of sensory cortices. [less ▲]

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailPsychological Approaches During Conscious Sedation. Hypnosis Versus Stress Reducing Strategies: A Prospective Randomized Study
Faymonville, Marie-Elisabeth ULg; Mambourg, P. H.; Joris, Jean ULg et al

in Pain (1997), 73(3), 361-7

Stress reducing strategies are useful in patients undergoing surgery. Hypnosis is also known to alleviate acute and chronic pain. We therefore compared the effectiveness of these two psychological ... [more ▼]

Stress reducing strategies are useful in patients undergoing surgery. Hypnosis is also known to alleviate acute and chronic pain. We therefore compared the effectiveness of these two psychological approaches for reducing perioperative discomfort during conscious sedation for plastic surgery. Sixty patients scheduled for elective plastic surgery under local anesthesia and intravenous sedation (midazolam and alfentanil upon request) were included in the study after providing informed consent. They were randomly allocated to either stress reducing strategies (control: CONT) or hypnosis (HYP) during the entire surgical procedure. Both techniques were performed by the same anesthesiologist (MEF). Patient behavior was noted during surgery by a psychologist, the patient noted anxiety, pain, perceived control before, during and after surgery, and postoperative nausea and vomiting (PONV). Patient satisfaction and surgical conditions were also recorded. Peri- and postoperative anxiety and pain were significantly lower in the HYP group. This reduction in anxiety and pain were achieved despite a significant reduction in intraoperative requirements for midazolam and alfentanil in the HYP group (alfentanil: 8.7 +/- 0.9 microg kg(-1)/h(-1) vs. 19.4 +/- 2 microg kg(-1)/h(-1), P < 0.001; midazolam: 0.04 +/- 0.003 mg kg(-1)/h(-1) vs. 0.09 +/- 0.01 mg kg(-1)/h(-1), P < 0.001). Patients in the HYP group reported an impression of more intraoperative control than those in the CONT group (P < 0.01). PONV were significantly reduced in the HYP group (6.5% vs. 30.8%, P < 0.001). Surgical conditions were better in the HYP group. Less signs of patient discomfort and pain were observed by the psychologist in the HYP group (P < 0.001). Vital signs were significantly more stable in the HYP group. Patient satisfaction score was significantly higher in the HYP group (P < 0.004). This study suggests that hypnosis provides better perioperative pain and anxiety relief, allows for significant reductions in alfentanil and midazolam requirements, and improves patient satisfaction and surgical conditions as compared with conventional stress reducing strategies support in patients receiving conscious sedation for plastic surgery. [less ▲]

Detailed reference viewed: 55 (7 ULg)
Peer Reviewed
See detailValidation of a fast voltage stability analysis method on the Hydro-Québec system
Van Cutsem, Thierry ULg; Mailhot, Richard

in IEEE Transactions on Power Systems (1997), 12

Detailed reference viewed: 26 (0 ULg)
Peer Reviewed
See detailDirectional solidification by appropriate chemically active single crystal seed: An alternative way of generating large superconducting 123 single domain
Cloots, Rudi ULg; Auguste, F. X.; Rulmont, André ULg et al

in Journal of Materials Research (1997), 12(12), 3199-3202

A Dy2O3 single crystal has been used as a seed for the growth of isothermally melt-textured DY-123 material. The nucleation-controlled step has been observed to be related to the heterogeneous nucleation ... [more ▼]

A Dy2O3 single crystal has been used as a seed for the growth of isothermally melt-textured DY-123 material. The nucleation-controlled step has been observed to be related to the heterogeneous nucleation of 211 particles at the surface of the dysprosium oxide single crystal. The subsequent growth mode seems to be controlled by a high concentration gradient of dysprosium in the liquid phase. This leads to a directional solidification process of the 123 phase. The size of the 211 particles seems to decrease as the distance from the dysprosium oxide single crystal increases. [less ▲]

Detailed reference viewed: 33 (3 ULg)
Peer Reviewed
See detailPharma-clinics. Comment je traite ... Une infection par le VIH. II. Inhibiteurs nucléosidiques de la transcriptase reverse
Moutschen, Michel ULg; Nkoghe, D.; Leonard, Philippe ULg et al

in Revue Médicale de Liège (1997), 52(12), 750-2

Detailed reference viewed: 23 (5 ULg)
Peer Reviewed
See detailLe prix d'une profession de foi
Duchesne, Jean-Patrick ULg

in Les amis de Ianchelevici (1997), 15

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailMorphometric Study of the Equine Navicular Bone: Comparisons between Fore and Rear Limbs
Gabriel, Annick ULg; Yousfi, S.; Detilleux, Johann ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1997), 44(9-10), 579-94

Navicular bones collected from the four limbs of 95 sound horses were studied. The anatomic bases have been laid down about morphometry of the navicular bones and their variations according to limbs ... [more ▼]

Navicular bones collected from the four limbs of 95 sound horses were studied. The anatomic bases have been laid down about morphometry of the navicular bones and their variations according to limbs, after corrections have been made for morphologic type, gender, weight, size and age. All the dimensions of the navicular bone (except for the thickness) were larger in the fore limb. This phenomenon probably reflects an attempt to compensate for the greater forces exerted upon the fore limbs during exercise and at rest. Navicular bones collected from the four limbs of 61 sound horses were studied and the anatomic bases were described for histomorphometry of the fore and rear navicular bones. Fore navicular bones possess less cortical bone at the level of the articular surface, as well as at the level of the flexor surface and proximal border, but larger amounts of cancellous bone. Articular and flexor surface cortical bone show a larger porosity in the fore navicular bones and a larger amount of mineralized cartilage. The mineralized portion for distal impar- and collateral sesamoidean ligaments are also larger for the fore navicular bones. Two distinct zones are observed for the flexor surface cortex that have never been reported in the literature before: an external zone, which is mainly composed of poorly remodelled lamellar bone, arranged in a disto-proximal oblique direction, and an internal zone, which is mainly composed of secondary bone, with a latero-medial direction of Haversian canals. Bone architecture is discussed with regard to the mechanic load, encountered by the bone during locomotion. [less ▲]

Detailed reference viewed: 25 (10 ULg)
See detailLa motivation en contexte scolaire : Points de vue de parents et d'élèves
Beckers, Jacqueline ULg; Stegen, Pierre

in Puzzle (1997), 3

Detailed reference viewed: 49 (6 ULg)
Peer Reviewed
See detailComparison between Three- and Four-Element Windkessel Models to Characterize Vascular Properties of Pulmonary Circulation
Lambermont, Bernard ULg; Gérard, Paul ULg; Detry, Olivier ULg et al

in Archives of Physiology & Biochemistry (1997), 105(7), 625-32

In 11 anaesthetised pigs the accuracy of the three-element (WK3) and the four-element (WK4) Windkessel models to describe hemodynamic properties of the pulmonary circulation was compared during six ... [more ▼]

In 11 anaesthetised pigs the accuracy of the three-element (WK3) and the four-element (WK4) Windkessel models to describe hemodynamic properties of the pulmonary circulation was compared during six different experimental conditions increasing pulmonary arterial pressure: increase in left atrial pressure, increase in alveolar pressure, increase in pulmonary blood flow, endotoxin shock, mechanical obstruction of left pulmonary artery or histamine infusion. Our results showed that WK4 fitted better the data than did WK3 because values of 1-R2 decreased from 6 percent (WK3) to 1.4 percent (WK4) when WK4 was used (P < 0.0005). 1-R2 was an adequate marker of the accuracy of the linear regression used to solve equations of both models. Compliance values estimated by WK4 were decreased by 5% comparatively to WK3 (P = 0.008). However, this difference can be considered as not physiologically relevant. Values of characteristic resistance corresponding to R1 + (L/R2C) in WK4 and to R1 in WK3 were not different (P = 0.22). The relative changes in R1, R2, and C observed due to the different experimental conditions were comparable regardless of the model. In conclusion, the conversion of WK3 in WK4 by adding an inductance, whose physiological meaning is not clear, resulted in an increased statistical accuracy of the model, but did not seem to have relevant influence on parameters or their evolution during experimental conditions. [less ▲]

Detailed reference viewed: 93 (2 ULg)