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See detailEfficacité du piège à fosse pour la collecte d' Hypnoidus riparius (Fabricius) (Coleoptera, Elateridae)
Jeuniaux, C.; Dufrêne, Marc ULg

in Bulletin et Annales de la Société Royale Belge d’Entomologie = Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1995), 131

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See detailAnalysis of Liquid Flow Distribution in Trickling Flow Reactor Using Computer-Assisted X-Ray Tomography
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Chemical Engineering Research & Design : Transactions of the Institution of Chemical Engineers Part A (1995), 73(A3), 258-262

In this paper, we propose a new experimental technique, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling flow reactors. Tomography refers to the ... [more ▼]

In this paper, we propose a new experimental technique, based on X-ray tomography, allowing the analysis of the gas-liquid-solid phase distribution in trickling flow reactors. Tomography refers to the cross-sectional imaging of an object from data collected by illuminating this object from many directions. The experimental set-up allows the scanning of transverse sections of rather large columns: up to 0.8 m diameter and 2 m height can be irradiated. Experiments were carried out both without and with liquid flow. In the absence of liquid, the reconstructed images give a view of the non-uniformity of the solid phase distribution. The images obtained are very complex because they result from the superposition of several distributions with different Spatial scales. We show the existence of a first spatial scale which allows us to separate properties belonging to the individual packing elements from those belonging to the bed scale. When liquid is flowing through the packed bed X-ray scans give a clear picture of the distribution of the liquid phase saturation, despite the very low liquid film thickness. Average values of this liquid phase saturation are determined and confronted with a partial wetting model. [less ▲]

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See detailAspects hémodynamiques de l'insulinorésistance: des concepts théoriques à la thérapeutique.
Paquot, Nicolas ULg; SCHEEN, André ULg; Lefebvre, P.

in Médecine et Hygiène (1995), 53

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See detailRetinopathy, but not neuropathy, is influenced by the level of residual endogenous insulin secretion in type 2 diabetes.
Bozet, Marie-Claire ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Diabète & Métabolisme (1995), 21(5), 353-9

The files of 132 patients with Type 2 diabetes were retrospectively studied to characterize the influence of metabolic control and residual insulin secretion on neuropathy and retinopathy, the two most ... [more ▼]

The files of 132 patients with Type 2 diabetes were retrospectively studied to characterize the influence of metabolic control and residual insulin secretion on neuropathy and retinopathy, the two most frequent degenerative diabetic complications. Patients were classified according to their metabolic control (mean HbA1C either < or > or = 8%; reference values: 3-6%) and residual endogenous insulin secretion (fasting plasma C-peptide levels either < or > or = 0.600 nmol/l). Neuropathy was more frequent in patients with poor metabolic control (32/64 = 50%) than in those adequately controlled (17/68 = 25%; p < 0.005). In both subgroups, the level of endogenous insulin secretion did not influence the prevalence of neuropathy. Retinopathy was less effected than neuropathy by the degree of metabolic control (37.5% in the subgroup with HbA1C > or = 8% v.s. 25% in the subgroup with HbA1C < 8%; p < 0.10), but was influenced by residual insulin secretion. Indeed, in patients with inadequate metabolic control, the prevalence of retinopathy was significantly increased in those with higher endogenous insulin secretion (51.4 versus 20.6%, p < 0.02) and thus probably higher insulin resistance. Furthermore, higher systolic arterial blood pressure was observed in the subgroups with a higher prevalence of retinopathy. Such conclusions were confirmed using multivariate analysis. Thus, in Type 2 diabetes, neuropathy is essentially affected by the degree of metabolic control, whereas retinopathy is also influenced by the level of residual endogenous insulin secretion and the presence of systolic hypertension. [less ▲]

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See detailLogica en esthetica. Notities bij ‘Het bordeel van Ika Loch’ van Paul van Ostaijen
Spinoy, Erik ULg

in Spiegel der Letteren (1995), 37(2-3), 89-128

This article is an innovative rereading of Van Ostaijen's grotesque story 'Ikla Loch's Brothel', in light of the author's late philosophical views.

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See detailApport des données RSO de ERS1 dans l’étude bathymétrique et pour la cartographie des zones intertidales
Cornet, Yves ULg; Ozer, André ULg; Ferrari, M.

in Documents de travail du Centre National de Recherches Géomorphologiques (1995), 30

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See detailOn the presence of a day-of-the-week effect in the foreign exchange market
Corhay, Albert ULg; Fatemi, Ali M; Tourani-Rad, Alireza

in Managerial Finance (1995), 21(8), 32-43

The purpose of this paper is to study the presence of the day-of-the-week effect in the foreign exchange market using an extensive data set of six exchange rates and employing two alternative types of ... [more ▼]

The purpose of this paper is to study the presence of the day-of-the-week effect in the foreign exchange market using an extensive data set of six exchange rates and employing two alternative types of distributional assumptions and also distribution-free tests. Our findings support the hypotheses of higher Wednesday returns prior to October 1, 1981, for the British pound, the Canadian dollar, the Deutsch mark, the French franc, the Swiss franc and the Japanese yen. Pursuant to the change in the settlement procedures which took effect October 1, 1981, the differential Wednesday returns disappear. [less ▲]

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See detailRectovaginal septum, endometriosis or adenomyosis: laparoscopic management in a series of 231 patients.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise et al

in Human Reproduction (1995), 10(3), 630-5

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases ... [more ▼]

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases. In three cases, the bowel lumen was entered. No other peri-operative complications were observed. Three cases of urinary retention were reported. The nodule resection resulted in considerable pain relief. Histologically, the rectovaginal nodule was similar to an adenomyoma. Indeed it was a circumscribed nodular aggregate of smooth muscle and endometrial glands. This form of disease must be considered as a specific disease which originates from the Mullerian rests present in the rectovaginal septum and we suggest that it be called 'rectovaginal adenomyosis'. [less ▲]

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See detailIn vitro modulation of keratinocyte attachment by minocycline H-Cl
Van Heusden, Alain ULg; Rompen, Eric ULg; Lebfevre, P. et al

in Journal of Dental Research (1995), 74

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See detailThe Cenozoic evolution of the strontium and carbon cycles: Relative importance of continental erosion and mantle exchanges
Godderis, Y.; François, Louis ULg

in Chemical Geology (1995), 126(2), 169-190

The past variations of the seawater Sr-87/Sr-86 isotopic ratio are related to changes in the relative contribution of the mantle Sr input to the ocean and the Sr supply from continental weathering ... [more ▼]

The past variations of the seawater Sr-87/Sr-86 isotopic ratio are related to changes in the relative contribution of the mantle Sr input to the ocean and the Sr supply from continental weathering. Recently, it has been postulated that the Cenozoic increase in the seawater Sr-87/Sr-86 isotopic ratio was associated with the uplift of the Himalayan and Andean mountains at that time. These orogenies may have changed the Sr isotopic ratio of the continental rocks undergoing weathering (as a result of extensive metamorphism), increased the river flux of Sr through enhanced weathering in these regions and possibly caused the global climatic cooling trend of the Cenozoic. A model of the major geochemical cycles coupled to an energy balance climate model is used to explore the possible causes of the Mesozoic-Cenozoic fluctuations in the seawater Sr-87/Sr-86 isotopic ratio. The contribution of the mantle exchanges at mid-ocean ridges, of the recycling of seafloor carbonates through plate margin volcanism and of the alteration of seafloor basalts to the fluctuations of the seawater Sr-87/Sr-86 isotopic ratio are studied. Finally, this model tentatively describes the impact of the Himalayan orogeny on the geochemical cycles of Sr and C. Some possible effects of the extensive metamorphism associated with the India-Asia collision and of the Himalayan uplift are modelled. The model reproduces the Cenozoic increase of the seawater Sr-87/Sr-86 isotopic ratio. However, the impact of the Himalayan orogeny on the C cycle appears to be limited and insufficient to generate the global climatic cooling of the Cenozoic. Rather, in the model, the Cenozoic cooling is mostly due to the reduction of the CO2 emission from mid-ocean ridge volcanism and to changes in the chemical weathering rates in the rest of the world excluding the Himalayas. [less ▲]

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See detailMeasuring productive performance in the non-life insurance industry: the case of French and Belgian markets
Fecher-Bourgeois, Fabienne ULg; Pestieau, Pierre ULg; Perelman, Sergio ULg et al

in Tijdschrift voor Economie en Management (1995), (40), 47-69

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See detailCeci est mon corps
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5),

This is a special issue on the body in literature and art.

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See detailRéalisation d'un appareillage mesure de l'anisotropie magnétique et application aux supraconducteurs à haute température critique
Vanderbemden, Philippe ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1995), 12

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See detailAcetic acid esters synthesis catalysed by Candida antarctica lipase.
Fonteyn, Fabienne ULg; Lognay, Georges ULg; Marlier, M.

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30(3), 183-188

Synthesis of various acetates catalysed by the Candida antarctica SP435 lipase was carried out in n-heptane. Reactions progress was established over a one hour period. Differences appeared in function of ... [more ▼]

Synthesis of various acetates catalysed by the Candida antarctica SP435 lipase was carried out in n-heptane. Reactions progress was established over a one hour period. Differences appeared in function of the structure and the chain length of alcohols: linalool and menthol were not esterified whereas the esterification of 1-dodecanol gave the highest rate (474 micromole per min and per g) and yield (86 per cent). [less ▲]

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See detailAnomalous pion decay in effective QCD at finite temperature
Blaschke, David; Jaminon, Martine ULg; Kalinovsky, Yu. L. et al

in Nuclear Physics A (1995), 592

The width of the process π0 → γγ is calculated within effective QCD at finite temperature. We use two different effective models which describe chiral symmetry breaking and its restoration at finite ... [more ▼]

The width of the process π0 → γγ is calculated within effective QCD at finite temperature. We use two different effective models which describe chiral symmetry breaking and its restoration at finite temperature in SU(2)ƒ: (i) an effective lagrangian with a nonlocal separable interaction kernel, (ii) A- and B-scaledNJL lagrangians which implement the scale anomaly of QCD. We calculate the temperature dependences of the quark and pion masses as well as of the pion-park-antiquark coupling strength below and above the double quark mass threshold. At zero temperature we obtain a fairly good agreement with the experimental value for the decay width. The temperature dependence of the decay width is related to that of the pion mass. Γπ0 → γγ is enhanced in the vicinity of the Mott temperature (Mπ = 2mq) for the nonlocal as well as for the A-scaled model and suppressed for the B-scaled model. We compare our results with the SU(2) Nambu-Jona-Lasinio model which is contained as a limiting case in our approach. [less ▲]

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See detailRegulation of gill prolactin receptors in tilapia (Oreochromis niloticus) after a change in salinity or hypophysectomy
Auperin, B.; Rentier-Delrue, Françoise ULg; Martial, Joseph ULg et al

in Journal of Endocrinology (1995), 145(2), 213-20

Prolactin (PRL) receptors in gill tissue have been analyzed in tilapia (Oreochromis niloticus) after transfer from fresh water (FW) to brackish water (BW). This study has indicated the presence of only ... [more ▼]

Prolactin (PRL) receptors in gill tissue have been analyzed in tilapia (Oreochromis niloticus) after transfer from fresh water (FW) to brackish water (BW). This study has indicated the presence of only one class of tilapia PRL (tiPRL) receptor whatever the salinity. After transfer, however, the percentage of specific binding of the two forms of tiPRL (tiPRLI and tiPRLII) increased significantly. Scatchard analysis of tiPRLI binding indicated an increase in receptor affinity, an effect which was not accompanied by any change in receptor specificity. Transfer to BW also caused the number of tiPRL receptors to increase rapidly, remaining high in fish adapted to BW for 28 days. Based on the sharp reduction in plasma tiPRLI and tiPRLII levels after transfer to BW, one possible explanation may be that tiPRL itself is an important factor regulating the number of free receptors. This hypothesis finds support in the fact that the number of tiPRL receptors also increased in hypophysectomized fish reared in FW. However, the absence of change in receptor affinity after hypophysectomy suggested that yet other factors are involved in tiPRL receptor regulation during the transfer from FW to BW. The paradoxically high numbers of tiPRL receptors in the gills of BW-adapted tilapia, even though PRL is known to be a FW-adapting hormone, is discussed with regard to the environment in which tilapia live. [less ▲]

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See detailModulation of the Expression of Interstitial and Type-Iv Collagenases in Coculture of Ht1080 Fibrosarcoma Cells and Fibroblasts
Munaut, Carine ULg; Noël, Agnès ULg; Weidle, U. H. et al

in Invasion & Metastasis (1995), 15(5-6), 169-78

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases ... [more ▼]

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases (gelatinases A and B) in a model of coculture of human fibroblasts and HT 1080 fibrosarcoma cells. The interstitial collagenase activity, mainly found in the conditioned medium of fibroblasts, and its mRNA level were increased in the in vitro coculture model. In contrast, gelatinase A was produced by both cell types. The HT 1080 cells additionally synthesised gelatinase B. In coculture, an enhancement of gelatinase A and the presence of its activated form were observed. Northern blot analysis demonstrated that this enzymatic enhancement occurred at a pretranslational level. The stimulation of the interstitial collagenase activity was partially mediated through soluble factor(s), whereas increased gelatinase A appeared to require direct cell-cell interactions. The extracellular matrix component, type-I collagen, stimulated the enzymatic activities released by the individual cells, but it did not modulate the synthesis of interstitial collagenase in coculture. Our results demonstrate that distinct MMPs are modulated by distinct mechanisms, all depending on specific interactions between tumour cells and host fibroblasts. [less ▲]

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See detailLa climatologie comme facteur modifiant du projet urbain
Dupagne, Albert ULg; Leclercq, Pierre ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailPulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1995), 42(8), 531-544

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in ... [more ▼]

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies. [less ▲]

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See detailContribution de la chimie macromoléculaire à l'élaboration de matériaux colloïdaux et microparticulaires destinés à la vectorisation de médicaments
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Innovation et Technologies en Biologie et en Médecine (1995), 16

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological ... [more ▼]

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological target. The aim of the paper is to give some insight about the contribution of the macromolecular engineering for the development of two vectors : microparticles of a control biodegradation rate designed for the chemoembolization of hepatocarcinoma , amphiphile copolymeric micelles able to transport drug within the targeted cells. Starting from a synthetic polymer : polylactide, degradation rate caracteristics , and functionalities can be tailored for the intended applications. One of the major problems , and largely underestimated in the past , for the successfull design of polymeric carrier is to take into account the interaction of proteins with polymer surfaces. [less ▲]

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See detailEvaluation of cryopreservation techniques for goat embryos
Fiéni, F.; Beckers, Jean-François ULg; Buggin, M. et al

in Reproduction Nutrition Development (1995), 35

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See detailRenouvellement de la couche cornée
Pierard, Gérald ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg

in Desquamation Adhesion (1995)

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See detailL'hypothyroidie subclinique.
Moreau, L.; Beckers, Albert ULg

in Revue Médicale de Liège (1995), 50(4), 171-4

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie ... [more ▼]

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie affectant surtout les personnes âgées est justifié par l'existence de troubles du bilan lipidique, de goitres et de perturbations neuropsychologiques. Celui-ci repose sur l'administration de lévothyroxine à dose minimale pour normaliser la TSH [less ▲]

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See detailTreatment of Clostridium difficile colitis. Summary of a round table held in Brussels on March, 3rd, 1994.
Delmée, Michel; Melin, Pierrette ULg; Peetermans, Willy et al

in Acta Clinica Belgica (1995), 50(2), 114-6

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea ... [more ▼]

Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea with metronidazole while maintaining the use of oral vancomycin in serious or life-threatening colitis. Clostridium difficile is a common cause of diarrhoea after antibiotic therapy and induces a spectrum of diseases ranging from mild diarrhoea to pseudomembranous colitis (PMC). It is considered to be the first cause of diarrhoea occurring among hospitalized patients (1). [less ▲]

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See detailAssessment of lipoxygenase activity in seed extracts from 35 plant species
Fauconnier, Marie-Laure ULg; Vanzeveren, E.; Marlier, Michel et al

in Grasas y Aceites (1995), 46(1), 6-10

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several ... [more ▼]

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several species of Vigna (V. unguiculata, V. radiata and V. mungo) and one of Trifolium exhibit stronger lipoxygenase activity than soybean enzyme extracts. The pH-activity relationship was also established for 4 very active samples. GCMS analysis revealed equal amounts of 9- and 13 hydroperoxides of linoleic acid In these seed extracts, indicating no enzyme positional specificity. [less ▲]

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See detailGuianensine, a zwitterionic alkaloid from Strychnos guianensis
Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg; Warin, Roger et al

in Phytochemistry (1995), 40(5), 1557-1560

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new ... [more ▼]

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new alkaloid has a zwitterionic asymmetrical bis-indole structure and is named guianensine. [less ▲]

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See detailAdhesion and costimulatory molecules on human FDC in vitro.
Tsunoda, R.; Heinen, Ernst ULg; Imai, Y. et al

in Advances in Experimental Medicine and Biology (1995), 378

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See detailThermohydrodynamical modelling of a power plant implementation in the Zeebrugge harbour
Beckers, Jean-Marie ULg; Vanormelingen, J.-J.

in Journal of Hydraulic Research (1995), 33(2), 163-180

A mathematical model and numerical simulation has been used to test the validity of a water and thermal circulation scheme induced by the implementation of a new power plant in the Zeebrugge harbour. The ... [more ▼]

A mathematical model and numerical simulation has been used to test the validity of a water and thermal circulation scheme induced by the implementation of a new power plant in the Zeebrugge harbour. The aim of the study was to: a) verify that in the interior basin of the inner harbour, a sufficient stratification is present to allow for the capture of cold bottom waters, whereas the ejected heated water remains at the surface and is evacuated to the main harbour, b) study the way the water cools in the main harbour and to quantify the amount of thermal energy which is pumped back into the inner harbour, c) determine if the global heat excess is evacuated and if the resulting temperature increase remains within reasonable limits at the power plant pump inlet. The study, accomplished in three steps, determined the parameters that control the recirculation (e.g. atmospheric conditions) and what their relative importance is. It was shown that a stratification is created in the interior basin. In the main harbour the heat evacuation is done primarily by evaporation in the harbour and only for 20% by the outflow to the open sea. Extreme temperature increases at the pump inlet are expected to be 1.6 degrees C and 6.6 degrees C,but generally the temperature increase lies between 3-4 degrees C. The actual value was found to be most sensitive to the atmospheric conditions. [less ▲]

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See detailHuman germinal center CD4+CD57+ T cells act differently on B cells than do classical T-helper cells.
Bouzahzah, F.; Bosseloir, A.; Heinen, Ernst ULg et al

in Developmental Immunology (1995), 4(3), 189-97

We have isolated two subtypes of helper T cells from human tonsils: CD4+CD57+ cells, mostly located in the germinal center (GC), and CD4+CD57- cells, distributed through the interfollicular areas but also ... [more ▼]

We have isolated two subtypes of helper T cells from human tonsils: CD4+CD57+ cells, mostly located in the germinal center (GC), and CD4+CD57- cells, distributed through the interfollicular areas but also present in the GC. In a functional study, we have compared the capacities of these T-cell subtypes to stimulate B cells in cocultures. In order to block T-cell proliferation while maintaining their activation level, we pretreated isolated T cells with mitomycin C prior to culture in the presence of B cells and added polyclonal activators such as PHA and Con A, combined or not with IL-2. Contrary to CD4+ CD57- cells, CD4+CD57+ cells did not markedly enhance B-cell proliferation. Even when sIgD.B cells typical of germinal center cells were tested, the CD4+CD57+ cells had no significant effect. This is in accordance with the location of these cells: They mainly occupy the light zones of the GC where few B cells divide. Even when added to preactivated, actively proliferating cells, CD4+CD57 cells failed to modulate B-cell multiplication. On the supernatants of B-cell-T-cell cocultures, we examined by the ELISA technique the effect of T cells on Ig synthesis. Contrary to CD57+ T cells, whose effect was strong, CD57- T cells weakly stimulated Ig synthesis. More IgM than IgG was generally found. Because CD57 antigen is a typical marker of natural killer cells, we tested the cytolytic activity of tonsillar CD4+CD57+ cells on K562 target cells. Unlike NK cells, neither CD4+CD57+ nor CD4+CD57- cells exhibit any cytotoxicity. Thus, germinal center CD4+CD57+ cells are not cytolytic and do not strongly stimulate either B-cell proliferation or Ig secretion. CD4+CD57- cells, however, enhance B-cell proliferation and differentiation, thus acting like the classical helper cells of the T-dependent areas. [less ▲]

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See detailComment j'explore ... Une anorexie mentale.
Scheen, André ULg

in Revue Médicale de Liège (1995), 50(12), 538-9

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See detailInhibition of growth of normal and human papillomavirus-transformed keratinocytes in monolayer and organotypic cultures by interferon-gamma and tumor necrosis factor-alpha.
Delvenne, Philippe ULg; al-Saleh, W.; Gilles, Christine ULg et al

in American Journal of Pathology (1995), 146(3), 589-98

The growth response of normal and human papillomavirus (HPV)-transformed cervical keratinocytes to interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha was investigated in monolayer and ... [more ▼]

The growth response of normal and human papillomavirus (HPV)-transformed cervical keratinocytes to interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha was investigated in monolayer and organotypic raft cultures. The proliferation rates of monolayer cultures were assessed by [3H]TdR incorporation and fluorimetric DNA titration. The growth of keratinocytes in organotypic cultures was estimated by their ability to stratify on collagen rafts and by immunohistochemistry for Ki67 antigen expression. IFN-gamma reduced the DNA synthesis of normal and HPV-transformed keratinocytes in monolayer cultures and exerted a marked growth inhibitory effect in organotypic raft cultures. In control raft cultures, normal keratinocytes produced an epithelial sheet of approximately 10 cells in thickness that closely resembled normal cervical epithelium and was characterized by sparse Ki67 antigen-positive cells whereas HPV-transformed keratinocytes produced up to 15 poorly differentiated epithelial layers that were reminiscent of high grade cervical lesions seen in vivo and exhibited a full thickness Ki67 antigen expression. When normal and HPV-transformed keratinocytes were maintained in the presence of IFN-gamma, the epithelial sheet was reduced to a few cells in thickness and the density of Ki67 antigen-positive cells was decreased. A more pronounced growth inhibitory effect in monolayer and organotypic cultures was observed when IFN-gamma was associated with tumor necrosis factor-alpha Tumor necrosis factor-alpha alone reduced the DNA synthesis of normal keratinocytes but was significantly less effective than IFN-gamma to inhibit the growth of HPV-transformed keratinocytes. These results suggest that similar responses in vivo to regulatory molecules may play a role in the development of HPV-related lesions. [less ▲]

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See detailHeterotransplantation of Primary and Established Human Tumour Cells in Nude Mice
Noël, Agnès ULg; Borcy, V.; Bracke, M. et al

in Anticancer Research (1995), 15(1, Jan-Feb), 1-7

Previous successful transplantations of human tumour cells into athymic nude mice have been described when cells were injected with a reconstituted basement membrane (matrigel). We have compared the ... [more ▼]

Previous successful transplantations of human tumour cells into athymic nude mice have been described when cells were injected with a reconstituted basement membrane (matrigel). We have compared the development and the histology of tumours following injection with matrigel or with culture medium of a panel of tumour cells exhibiting different degrees of tumorigenicity. Two cell lines (MCF7 and MCF7/6) required matrigel in order to form tumours. When inoculated with matrigel, all the other cell lines tested [MCF7 gpt, MCF7ras, MCF7(AZ), MCF7(AZ)TD5, MDA-MB 231, HT1080] showed increased tumour take and reduced latency period. Human primary tumours (melanoma, breast and colon cancers) were transplanted successfully into nude mice, in the presence of matrigel. Breast primary tumours or cell lines gave rise to poorly differentiated carcinomas. The other tumours presented histopathological patterns typical of differentiated human cancers. [less ▲]

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See detailNimesulide
Dupont, L.; Pirotte, Bernard ULg; Masereel, B. et al

in Acta Crystallographica (1995), C51

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See detailBlues & African-American Literature. The Devil's Music in Novels of Nella Larsen,Gayl Jones and Toni Morrison. An Approach
Sacré, Robert ULg

in International Jazz Archives Journal (1995), vol.1(no.3), 93-106

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See detailThe role of bisphosphonates in the prevention and treatment of osteoporosis
Reginster, Jean-Yves ULg

in Clinical Rheumatology (1995), 14(3), 22-25

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See detailThrombospondin modulates human breast adenocarcinoma cell adhesion to human vascular endothelial cells.
Incardona, F.; Lewalle, J. M.; Morandi, V. et al

in Cancer Research (1995), 55(1), 166-73

hrombospondin (TSP), a M(r) 450,000 cytoadhesive glycoprotein, has been shown to potentiate tumor cell metastasis in mice by a mechanism that involves the hemostatic system of the host. In this study, the ... [more ▼]

hrombospondin (TSP), a M(r) 450,000 cytoadhesive glycoprotein, has been shown to potentiate tumor cell metastasis in mice by a mechanism that involves the hemostatic system of the host. In this study, the potential involvement of TSP in the interaction of human mammary adenocarcinoma MCF-7 cells with human umbilical vein endothelial cells (HUVECs) in culture was investigated. Using an ELISA, preconfluent HUVECs synthesized 100-fold more TSP than did MCF-7 cells during 24 h of culture (20 versus 0.2 microgram/10(6) cells). Confocal microscopy localized TSP within intercellular junctions between aggregated MCF-7 cells in suspension. On adherent cells, TSP exhibited a patchy distribution both on the cell surface and in the cytosol. In HUVECs, TSP strongly stained the perinuclear space and was also found in association with cytoskeletal microfibrils. Flow cytometric analysis indicated the presence of a large number of unoccupied receptors for TSP on MCF-7 cells. Binding studies using [125I]TSP demonstrated the presence of 1.6 x 10(6) sites/cell with an apparent Kd of 28 nM. Attachment of radiolabeled MCF-7 cells to a TSP-coated substrate and to HUVEC monolayers was inhibited in the presence of a polyclonal antibody to TSP (10 micrograms/ml) or increasing concentrations (1-10 micrograms/ml) of soluble TSP. Neither nonimmune IgG nor the cell adhesion peptide Gly-Arg-Gly-Asp-Ser (100 micrograms/ml) inhibited these interactions. Inhibition was also observed with heparin (10 micrograms/ml), suggesting the participation of TSP heparin-binding domain(s) and heparin-like molecules. In the presence of an excess of soluble TSP or anti-TSP antibody, MCF-7 cells did not form aggregates in suspension and preformed aggregates were readily dissociated by the addition of soluble TSP. These results indicate that mammary adenocarcinoma cells use TSP to form aggregates and to attach to human endothelial cells. These interactions may have physiological implications during the hematogenous spread of tumor cells. [less ▲]

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See detailAttitude of a Young Surgeon toward Experimental Surgery. Roles and Limits of Experimental Surgery
Defraigne, Jean-Olivier ULg

in Acta Chirurgica Belgica (1995), 95(2, Mar-Apr), 113-7

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is ... [more ▼]

At the moment, the place of experimental surgery within the clinical surgical cores is questioned. However, its role in the progresses of surgical practice and training of surgeons is undisputable. It is through research that surgeons can keep some critical mind, essential in their daily activities. However, too often actually, the surgeons abandon research. Two essential reasons explain the phenomenon: on the one hand, the weight of the clinical tasks and on the other hand the complexity of research founded on more and more specialized basic notions. In fact, the part of a surgical investigator must be to form a link between basic research and clinical activities. As such, work in collaboration with motivated basic investigators is cardinal. Also, the success of research depends upon the will of the departments to maintain a research activity, but it meets often with the difficulty in obtaining sufficient research credits. Finally, research can play an essential part in the education of the trainees and partly fill some gaps in their clinical training. [less ▲]

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See detailR-HuEPO hyporesponsiveness - who and why ?
Danielson, B.; Beguin, Yves ULg; Bommer, J. et al

in Nephrology Dialysis Transplantation (1995), 10

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See detailLa thermographie infrarouge dans l'étude de la thermorégulation : revue de la littérature
Spruyt, P.; Ghafir, Y.; Art, Tatiana ULg et al

in Annales de Médecine Vétérinaire (1995), 139

Infrared thermography is a method to assess the skin temperature by means of a camera equipped with an infrared detector. It makes thermograms that represents the surface temperature of skin patterns ... [more ▼]

Infrared thermography is a method to assess the skin temperature by means of a camera equipped with an infrared detector. It makes thermograms that represents the surface temperature of skin patterns. This article summerizes the different information about thermography and thermoregulation of horses. In fact, lots of information exist about thermoregulation of most of the domestic animais but very little exists as far as horses are concerned. Two different types of devices are used for thermography : contacting and noncontacting which measure the infrared radiation either with a thermometer or with a themographic camera. The blood circulation dictates the thermic model which is at the origin of thermographic interpretation. This latter is a good method helping to study thermoregulation. [less ▲]

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See detailEn Belgique, diverses modalités de pâturage pour des taurillons avant finition à l'auge
Dufrasne, Isabelle ULg; Gielen, Marc ULg; Limbourg, Pierre et al

in Fourrages (1995), 141

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See detailDe ruimtebeleving in Vestdijks Verzamelde verhalen III
Nachtergaele, Lutgarde ULg

in Vestdijkkroniek (1995), 88-89

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See detailTreatment of patent ductus arteriosus by placement of intravascular coils in a pup
Snaps, Frédéric ULg; Mc Entee, Kathleen ULg; Saunders, J. et al

in Journal of the American Veterinary Medical Association [=JAVMA] (1995), 6(6), 724-725

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a ... [more ▼]

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a large aortic base was outlined. A second selective angiographic procedure was performed to functionally close the PDA by use of thrombotic coils; complete obstruction was obtained. Twenty-four hours after the procedure, the murmur disappeared. One month later, the dog was reexamined and found to be clinically normal. [less ▲]

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See detailProgress from 1989 to 1992 in understanding the circulation of the Western Mediterranean Sea
Lehucher, P. M.; Beautier, L.; Chartier, M. et al

in Oceanologica Acta (1995), 18(2), 255-271

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the ... [more ▼]

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the physical processes responsible for seasonal and mesoscale variabilities. Observations (in situ and satellite), together with theoretical, physical and numerical models, have been widely used in the course of these studies. Attention has been focused on the dynamics of the northern basin (deep water formation, dynamics of the Northern Mediterranean Current, circulation and shelf/slope interaction in the Balearic Sea) and of the southern basin (Alboran Sea circulation, instabilities of the Algerian Current). The straits dynamics have been studied with particular reference to the Corsica channel. Preliminary runs of a basin-scale circulation model of the Western Mediterranean Sea forced by the straits are also presented. They are shown to be capable of generating a cyclonic circulation in the western basin. [less ▲]

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See detailFra Stein til Waldrop: sprogdigtningen og de nye prosadigtere
Delville, Michel ULg; Schatz-Jakobsen, Claus

in Den Blå Port: Tidsskrift for Litteratur (1995)

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See detailEstimation de la disponibilite de la ressource forestiere. Cas d'une essence traitée en futaie équienne monospecifique.
Hebert, Jacques ULg; Laurent, Christian

in Revue Forestière Française (1995), 47(5), 572-580

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See detailBORN EFFECTIVE CHARGES OF BARIUM-TITANATE - BAND-BY-BAND DECOMPOSITION AND SENSITIVITY TO STRUCTURAL FEATURES
Ghosez, Philippe ULg; GONZE, X.; LAMBIN, P. et al

in Physical Review. B : Condensed Matter (1995), 51(10), 6765-6768

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See detailTwo forms of lipase from Mucor miehei exhibit a different behavior at the air-water interface.
Blecker, Christophe ULg; Razafindralambo, Hary ULg; Paquot, Michel ULg et al

in Colloids and Surfaces B : Biointerfaces (1995), (3), 271-279

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See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

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See detailViolence et justice
Steinmetz, Rudy ULg

in Avancées (1995)

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See detailThe 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold
Carfi, A.; Pares, S.; Duée, E. et al

in EMBO Journal (1995), 14(20), 4914-4921

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See detailAcquis de la recherche en matière d'évaluation génétique des ovins et des caprins en Tunisie
D'Jemali, M'naouer; Jamal, Sofiene; Ben-Dhiaf, Sonia et al

in Cahiers Options Méditerranéennes (1995), 11

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 ... [more ▼]

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 flocks of Barbary sheep in 1987-92 are presented in 14 tables and discussed. [less ▲]

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See detailA PARAMETRIC ANALYSIS FOR THE DAFALIAS-KALIAKIN BOUNDING SURFACE VISCOPLASTIC MODEL-BASED ON THE DIFLUPRESS LD TEST
LEIDWANGER-RABIS, Cathy; CHAMBON, René; CATEL, P. et al

in Computers & Geotechnics (1995), 17(4), 473-505

In order to predict delayed settlements of heavy structures, the authors decided to use the elasto-viscoplastic model of Dafalias-Kaliakin. To identify the parameters of the constitutive equations, they ... [more ▼]

In order to predict delayed settlements of heavy structures, the authors decided to use the elasto-viscoplastic model of Dafalias-Kaliakin. To identify the parameters of the constitutive equations, they use above all the data of a new in-situ test, the Diflupress L.D. designed to approach the creep behavior of soil. In a first section, the principle of the model is presented. Then, the important parameters of the model are identified, mostly from in-situ test data since the laboratory tests data are not numerous and reliable. Finally, a study of sensitivity on the parameters which influence the viscoplastic response of the model is made. [less ▲]

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See detail3-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine
Dupont, l; Liégeois, Jean-François ULg; Rogister, F. et al

in Acta Crystallographica Section C-Crystal Structure Communications (1995), C51

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See detailVenous Allografts for Critical Limb Ischaemia
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1995), 95(1, Jan-Feb), 14-20

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level ... [more ▼]

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level. Recently, there is renewed interest in the use of preserved venous allografts as an alternate conduit in patients with threatened ischaemic limbs. From 1991 to 1993, the authors revascularized 12 ischaemic limbs with venous allografts (10 preserved at 4 degrees C, 2 Varivas grafts). The indication for operation was rest pain in five patients and tissue necrosis in seven. Nine patients had one or more previous ipsilateral revascularizations. The at 4 degrees C preserved venous allografts were conserved for a near period of 2 months. In only half (5/10) of the cases ABO isocompatibility could be respected. Distal anastomosis was always below the knee. In 6 patients, the anastomosis was at tibial level. There was one rupture of a Varivas graft on the fifth postoperative day, necessitating ligation of the graft and subsequent amputation. All other grafts remained patent for a mean period of 10.6 months. Actually, 6 grafts are still open. Most patients were given aspirin. Only three patients were under oral coumarin anticoagulation in an effort to prevent early graft failure. The limb salvage rate is 67% (8/12) (mean follow-up of 13 months). The authors discuss the clinical experience with venous allografts as published in recent literature. Use of venous allografts for arterial reconstruction in humans was met with limited success so far. The one year patency approximates 50%. Venous allografts progress in an ineluctable way to a fibrous conduit.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailImmunohistochemical identification of varicella-zoster virus gene 63-encoded protein (IE63) and late (gE) protein on smears and cutaneous biopsies: implications for diagnostic use.
Nikkels, Arjen ULg; Debrus, S.; Sadzot-Delvaux, Catherine ULg et al

in Journal of Medical Virology (1995), 47(4), 342-7

Early and specific recognition of varicella zoster virus (VZV) infection is of vital concern in immunocompromised patients. The aim of this study was to compare the diagnostic accuracy of histochemical ... [more ▼]

Early and specific recognition of varicella zoster virus (VZV) infection is of vital concern in immunocompromised patients. The aim of this study was to compare the diagnostic accuracy of histochemical and immunohistochemical identification of the VZV ORF63 encoded protein (IE63) and of the VZV late protein gE on smears and formalin-fixed paraffin-embedded skin sections taken from lesions clinically diagnosed as varicella (n = 15) and herpes zoster (n = 51). Microscopic examinations of Tzanck smears and skin sections yielded a diagnostic accuracy of Herpesviridae infections in 66.7% (10/15) and 92.3% (12/13) of varicella, and 74.4% (29/39) and 87.8% (43/49) of herpes zoster, respectively. Immunohistochemistry applied to varicella provided a type-specific virus diagnostic accuracy of 86.7% (13/15; IE63) and 100% (15/15; gE) on smears, and of 92.3% for both VZV proteins on skin sections. In herpes zoster, the diagnostic accuracy of immunohistochemistry reached 92.3% (36/39; IE63) and 94.9% (37/39; gE) on smears, and 91.7% (44/48; IE63) and 91.8% (45/49; gE) on skin sections. These findings indicate that the immunohistochemical detection of IE63 and gE on both smears and skin sections yields a higher specificity and sensitivity than standard microscopic assessments. [less ▲]

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See detailNucleic acid compartmentalization within the cell nucleus by in situ transferase-immunogold techniques.
Thiry, Marc ULg

in Microscopy Research and Technique (1995), 31(1), 4-21

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is ... [more ▼]

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is placed on the various nucleolar components and the various enigmatic structures of the extranucleolar region: interchromatin granules, coiled bodies, and simple nuclear bodies. These data are discussed in the light of our current understanding of the functional organization of the cell nucleus. [less ▲]

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See detail'Overlapping Territories, Intertwined Histories': Cross-Culturality in Caryl Phillips's Crossing the River
Ledent, Bénédicte ULg

in Journal of Commonwealth Literature (1995), 30(1), 55-62

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See detailApplication des transects pluviométriques spatio-temporels annuels à l’ensemble du territoire sahélien.
Ozer, Pierre ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailA microscopic study of barium titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1995), 164

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See detailGrowth hormone, Insulin-like growth factor-I and their plasma binding proteins in different cattle breeds
Renaville, Robert ULg; Devolder, Anne; Shojae, Djalil et al

in Zootecnica e Nutrizione Animale (1995), 21

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See detailSpecific bovine brucellosis diagnosis based on in vitro antigen-specific gamma interferon production.
Weynants, V.; Godfroid, J.; Limbourg, B. et al

in Journal of Clinical Microbiology (1995), 33(3), 706-12

In order to improve the specificity of the diagnosis of bovine brucellosis, we developed a test which can be regarded as an in vitro correlate of the delayed-type hypersensitivity test (DTH). A mixture of ... [more ▼]

In order to improve the specificity of the diagnosis of bovine brucellosis, we developed a test which can be regarded as an in vitro correlate of the delayed-type hypersensitivity test (DTH). A mixture of cytoplasmic proteins from Brucella melitensis B115 was used as a specific antigenic stimulus in bovine whole blood culture. Supernatants harvested at 18 to 24 h after the in vitro antigenic stimulus were assayed for their gamma interferon (IFN-gamma) content by using a commercial sandwich enzyme-linked immunosorbent assay kit. The IFN-gamma assay was evaluated with 10 heifers during the course (80 days) of an experimental infection and with 14 cows from an ongoing brucellosis outbreak. All of these animals were slaughtered, and pertinent organs were subjected to classical bacteriological analyses. In addition, we analyzed 23 field cases in which false-positive serological reactions occurred. The IFN-gamma results were compared with those of the standard DTH and a battery of serological assays, and they were correlated with bacteriological data. Both for the experimental infection and for the field brucellosis outbreak, the IFN-gamma assay detected infection in more animals than any combination of the serological tests, and it detected infection earlier than these tests. Finally, none of the samples from cows showing false-positive serological reactions was classified as positive by the IFN-gamma assay, attesting to its specificity and to its usefulness in interpreting ambiguous serological results. A rapid and convenient alternative to the DTH, the IFN-gamma assay appears to be an ideal method that is complementary to the serological diagnosis protocols. [less ▲]

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See detailBrazilandia. Over Brazil van John Updike.
Vanden Berghe, Kristine ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(1), 112-114

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See detail3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailAssessment of glucose metabolism in humans with the simultaneous use of indirect calorimetry and tracer techniques.
Tappy, L.; Paquot, Nicolas ULg; Tounian, P. et al

in Clinical Physiology (1995), 15(1), 1-12

Concomitant measurements of sytemic glucose delivery and carbohydrate oxidation are frequently performed in human investigations. Systemic glucose delivery (SGD) is usually determined using dilution of ... [more ▼]

Concomitant measurements of sytemic glucose delivery and carbohydrate oxidation are frequently performed in human investigations. Systemic glucose delivery (SGD) is usually determined using dilution of infused glucose tracers; net carbohydrate oxidation rate (net CHOOX) can be calculated from respiratory gas exchanges and urinary nitrogen excretion (indirect calorimetry); alternatively, glucose oxidation can be measured from labelled CO2 production during infusion of carbon-labelled glucose tracers. In this paper, the theory underlying the use of each of these techniques is briefly reviewed and qualitative differences are outlined. SGD represents the sum of hepatic glucogenolysis, gluconeogenesis from amino acids or glycerol, and, according to the glucose tracer used, glucose cycles (glucose-phosphate cycle, fructose-phosphate cycle, Cori and glucose-alanine cycles); systemic delivery of exogenous glucose after oral or i.v. glucose administration is also measured. Net CHOOX represents oxidation of glucose arising from hepatic or muscle glycogen or from exogenous glucose; it does not take into account oxidation of glucose formed from amino acids or glycerol, which is included in net protein or lipid oxidation. In contrast, isotopic determination of glucose oxidation corresponds to oxidation of glucose originating from hepatic glycogen breakdown, of exogenously administered glucose, and of glucose formed from amino acids and glycerol. Non-oxidative glucose disposal, calculated as SGD-net CHOOX, corresponds to the sum of gluconeogenesis from amino acids or glycerol (which are included in net protein and lipid oxidation), glucose cycles, and glycogen synthesis. [less ▲]

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See detailFormer par les stages
Jadoulle, Jean-Louis ULg

in Pédagogies. Cahiers du Laboratoire de Pédagogie Expérimentale de l'Université de Louvain (1995), X

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See detail3-Methyl-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailPacemaker Implantation for Early Sinus Node Dysfunction after Orthotopic Heart Transplantation
RADERMECKER, Marc ULg; Defraigne, Jean-Olivier ULg; Fourny, J. et al

in Acta Chirurgica Belgica (1995), 95(1), 31-4

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node ... [more ▼]

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node dysfunction were identified and were satisfactorily paced on the VVIR mode. All three showed sinus recovery within three months following implantation and had their pacemaker switched from the VVIR mode to a simple ventricular demand pacing. Interestingly, administration of beta-blocking drugs quickly reinstituted pace dependence. The patients' outcome is excellent (18 to 48 months follow-up). No difference with the global cohort of our OHT recipients was noticed, apart from an apparent high incidence of infections (3/3) with (2/3) CMV and severe rejection (3/3) during the first month postoperatively. This data suggests that sinus dysfunction may be the result of a multifactorial (rejection, CMV, ...) injury to the conduction system, and is only clinically relevant beyond a threshold level. Denervation hypersensitivity, together with correction of these factors, may account for the restoration of a sufficient reserve of conduction system, and therefore appropriate sinus node function in basal conditions. [less ▲]

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See detailNouveaux activateurs des canaux potassiques: conception, pharmacologie et perspectives thérapeutiques
Pirotte, Bernard ULg; Fontaine, J.; Lebrun, P.

in Journal de Pharmacie de Belgique (1995), 50

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See detailProfondeville/Rivière: Grotte du "Bois Laiterie"
Noiret, Pierre ULg

in Chronique de l'Archéologie Wallonne (1995), 3

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See detailOn the charge transfer pathway in the Merocyanine 540 triplet state quenching by nitroxyl radical
Hoebeke, Maryse ULg; Van de Vorst, A.

in Photochemistry & Photobiology (1995), 61

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See detailLocalization and transmembrane topology of a new member of the mitochondrial carrier family, the yeast RIM 2 gene product
El Moualij, B.; Duyckaerts, Claire ULg; Lamotte-Brasseur, J. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995)

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See detailGrowth hormone response to apomorphine in panic disorder: comparison with major depression and normal controls.
Pichot, W.; Hansenne, Michel ULg; Gonzalez Moreno, A. et al

in European Archives of Psychiatry & Clinical Neuroscience (1995), 245(6), 306-8

Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 ... [more ▼]

Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 male drug-free inpatients meeting Research Diagnostic Criteria for panic disorder who were compared with 10 male major depressive inpatients and 10 male normal controls. The three groups differed significantly in the GH peak response (mean +/- SD): 27.8 +/- 12.5 ng/ml in panics, 5.4 +/- 4.0 ng/ml in major depressives, and 25.8 +/- 11.3 ng/ml in normal controls (F(2,27) = 15.3; P = 0.00003). Although there were significant differences between panics and major depressives (P = 0.00004), and between major depressives and controls (P = 0.00004), panics did not significantly differ from controls. These results do not support the hypothesis of an overlap between panic and affective disorders, and suggest that the hypothalamo-GH-somatomedin axis could be intact in panic disorder. [less ▲]

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See detailFunctional analysis of the Antirrhinum floral homeotic DEFICIENS gene in vivo and in vitro by using a temperature-sensitive mutant.
Zachgo, S.; Silva, E de A; Motte, Patrick ULg et al

in Development (1995), 121(9), 2861-75

Flowers of the temperature-sensitive DEFICIENS (DEF) mutant, def-101, display sepaloid petals and carpelloid stamens when grown at 26 degrees C, the non-permissive temperature. In contrast, when ... [more ▼]

Flowers of the temperature-sensitive DEFICIENS (DEF) mutant, def-101, display sepaloid petals and carpelloid stamens when grown at 26 degrees C, the non-permissive temperature. In contrast, when cultivated under permissive conditions at 15 degrees C, the morphology of def-101 flowers resembles that of the wild type. Temperature shift experiments during early and late phases of flower development revealed that second and third whorl organ development is differentially sensitive to changes in DEF expression. In addition, early DEF expression seems to control the spatially correct initiation of fourth whorl organ development. Reduction of the def-101 gene dosage differentially affects organogenesis in adjacent whorls: at the lower temperature development of petals in the second whorl and initiation of carpels in the centre of the flower is not affected while third whorl organogenesis follows the mutant (carpelloid) pattern. The possible contribution of accessory factors to organ-specific DEF functions is discussed. In situ analyses of mRNA and protein expression patterns during def-101 flower development at 15 degrees C and at 26 degrees C support previously proposed combinatorial regulatory interactions between the MADS-box proteins DEF and GLOBOSA (GLO), and provide evidence that the autoregulatory control of DEF and GLO expression by the DEF/GLO heterodimer starts after initiation of all organ primordia. Immunolocalisation revealed that both proteins are located in the nucleus. Interestingly, higher growth temperature affects the stability of both the DEF-101 and GLO proteins in vivo. In vitro DNA binding studies suggest that the temperature sensitivity of the def-101 mutant is due to an altered heterodimerisation/DNA-binding capability of the DEF-101 protein, conditioned by the deletion of one amino acid within the K-box, a protein region thought to be involved in protein-protein interaction. In addition, we introduce a mutant allele of GLO, glo-confusa, where insertion of one amino acid impairs the hydrophobic carboxy-terminal region of the MADS-box, but which confers no strong phenotypic changes to the flower. The strong mutant phenotype of flowers of def-101/glo-conf double mutants when grown in the cold represents genetic evidence for heterodimerisation between DEF and GLO in vivo. The potential to dissect structural and functional domains of MADS-box transcription factors is discussed. [less ▲]

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See detailInter-individual variability of teachers' feedback: Study in simulated teaching conditions
Cloes, Marc ULg; Denève, Alain; Piéron, Maurice ULg

in European Physical Education Review (1995), 1(1), 83-93

Dans l'enseignement des activités physiques, les réactions de l'enseignant à la prestation des élèves (feedback) constituent l'une des variables déterminantes dans la réussite pédagogique. Les réactions à ... [more ▼]

Dans l'enseignement des activités physiques, les réactions de l'enseignant à la prestation des élèves (feedback) constituent l'une des variables déterminantes dans la réussite pédagogique. Les réactions à la prestation se caractérisent par une grande variabilité interindividuelle. Leur émission fait suite à un processus comportant deux phases: le diagnostic et la prescription. Afin de mettre en évidence le rôle exercé par les facteurs liés aux caractéristiques de l'enseignant sur celles de leurs interventions, nous avons comparé les réactions à la prestation émises par 12 éducateurs physiques lors d'une séance d'enseignement simulé. Grâce à cette technique vidéo, les sujets réagissent à partir de performances motrices identiques. Les feedback ont été comparés entre quatre groupes de sujets caractérisés par des niveaux d'expérience sportive et pédagogique similaires. Une analyse factorielle par correspondance a permis d'identifier des classes de sujets émettant des feedback de même type. Les résultats tendent à souligner que (1) le niveau d'expertise dans la pratique de l'activité enseignée exerce une influence sur la première de ces phases; (2) le degré d'expertise pédagogique contribue à améliorer l'émission du message. [less ▲]

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See detailMise au point d’une classification automatique des cartes synoptiques d’altitude et application à l’étude des incendies de forêts
Mabille, Georges; Geron, Jean-Marc; Funcken, Philippe et al

in Publication Association Internationale de Climatologie (1995), 8

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See detailCarte des sols de Belgique et SIG : un traitement préalable visant à la concordance géométrique
Lejeune, Philippe ULg

in Bulletin des Recherches Agronomiques de Gembloux (1995), 30(4), 339-351

Almost half (40 %) of the sheets of the Belgian Soil Map (scale 1/20,000) has been produced on a topographical background showing geometrical differences, sometimes important, with the basic topographic ... [more ▼]

Almost half (40 %) of the sheets of the Belgian Soil Map (scale 1/20,000) has been produced on a topographical background showing geometrical differences, sometimes important, with the basic topographic background produced at present by the National Institute of Geography. Twenty percent of control points georeferenced on a test sheet show differences higher than 80 meters between the two reference systems. A simple method is proposed to match up inaccurate sheets of the soil map with the basic topographic background and to reduce these differences. It is based on control points evenly distributed on the sheet to be corrected and georeferenced in the two systems. A translation is applied to the poiints digitised on the soil map, corresponding to a weighed mean of the differences observed on the nearest control points, the weighing factor being computed on the basis of distances between control points and the element to be corrected. This procedure is integrated in a program running on a PC in Arc/Info environment. The entire correction process (identification of control points, preparation of files, program execution) takes less than three hours per sheet. [less ▲]

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See detailThe continuum of cytokine involvement in the physiology of reproduction
Geenen, Vincent ULg; Hazee, Marie-Thérèse ULg; Goxe, Béatrice et al

in GENESIS (1995), 14

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See detailLate Lower and Middle Devonian Miospores from Saudi Arabia.
Loboziak, S; Streel, Maurice ULg

in Review of Palaeobotany and Palynology (1995), 89

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See detailKozani-Grevena Earthquake and the Active tectonics of Northern Greece
Meyer, B.; Armijo, R.; Hubert, Aurelia ULg et al

Scientific journal (1995)

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See detailHet is nooit goed. Marginalia bij De pasvorm van de goede smaak van Marc Reynebeau
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(3-4), 111-121

This article criticizes the illusions of normative literary criticism, which hopes to determine 'once and for all' the true and objective value of literature.

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See detailFamilial trends of obesity through three generations: the Belgian-Luxembourg child study.
Guillaume, Michèle ULg; Lapidus, L.; Beckers, F. et al

in International Journal of Obesity (1995), 19 Suppl 3

Province de Luxembourg in Belgium is an area with clustering of obesity as well as other risk factors for cardiovascular diseases and non-insulin dependent diabetes mellitus. In this study, obesity was ... [more ▼]

Province de Luxembourg in Belgium is an area with clustering of obesity as well as other risk factors for cardiovascular diseases and non-insulin dependent diabetes mellitus. In this study, obesity was studied in a total of 1028 boys and girls in age-strata 6-8, 8-10, 10-12 years, selected at random from school classes. Participation rate was about 70%. Non-participants did not differ from participants in comparisons of school records of height and weight. Furthermore, information on birth weight, parents' height and weight was collected, as well as reported problems of obesity in grandparents. The results show a high prevalence of pronounced obesity in these children. BMIs were strongly correlated between the children and both parents. Furthermore, grandparents' obesity problems were related to the BMI of parents, and also to obesity indices in the children. Birth weights were related to current BMI of the children (in girls only for the youngest age-group), and to their mothers' BMI. It was concluded that obesity is prevalent in this area and can be traced through three generations, and seems to be discoverable already at birth. Energy intake is high and physical activity level is low in these children. However, statistical analyses suggest that familial factors exert a greater impact than environmental factors on the BMI of the children. These results, as well as the wide-spread, consistent familial clustering of obesity, traceable already at birth, suggest influence of strong genetic traits for obesity in this population. [less ▲]

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See detailNumerical simulation of a full scale fire test on a loaded steel framework
Franssen, Jean-Marc ULg; Cooke, C. M. E.; Latham, D. J.

in Journal of Constructional Steel Research (1995), 35

A single bay single storey steel portal frame has been tested under fire conditions. It is here simulated using hte non linear computer code CEFICOSS. The elements have composite steel-concrete sections ... [more ▼]

A single bay single storey steel portal frame has been tested under fire conditions. It is here simulated using hte non linear computer code CEFICOSS. The elements have composite steel-concrete sections for the thermal analysis, but only the steel part of the sections is load bearing. [less ▲]

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See detailSimulation of Square Cup Deep Drawing with Different Finite Elements
Kaiping, Li; Habraken, Anne ULg; Bruneel, H.

in Journal of Materials Processing Technology (1995), 50(1-4), 81-91

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See detailCeci est mon corps. Een inleiding
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5), 4-10

This is an introduction to a special issue on the body in art and literature.

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See detailLe determinisme genetique de la differenciation sexuelle humaine.
Ectors, Fabien ULg

in Revue Médicale de Bruxelles (1995), 16(6), 404-10

The genetic mechanism controlling sexual differentiation had remained unknown for a long time. Karyotype analysis of sex-inverted patients or individuals with ambiguous sexual differentiation has enabled ... [more ▼]

The genetic mechanism controlling sexual differentiation had remained unknown for a long time. Karyotype analysis of sex-inverted patients or individuals with ambiguous sexual differentiation has enabled the localization and identification of genes involved. It is currently known that the SRY gene is responsible for the initiation of a cascade reaction leading to male differentiation of the primitive gonad. SRY is a +/- 820 base pairs gene located on the small arm of the Y chromosome, more precisely within the 1A1 alpha sub-segment. Although a few other genes are known to be involved in the downstream regulation of SRY, their precise mode of action is yet unknown. [less ▲]

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See detailGalectin-3, a Laminin Binding Protein, Fails to Modulate Adhesion of Human Melanoma Cells to Laminin
van den Brule, F. A.; Buicu, C.; Sobel, M. E. et al

in Neoplasma (1995), 42(5), 215-9

Galectin-3 is a laminin binding protein which expression is altered in a variety of human carcinomas including colon, breast and endometrium. In these tumors, we consistently observed a down regulation of ... [more ▼]

Galectin-3 is a laminin binding protein which expression is altered in a variety of human carcinomas including colon, breast and endometrium. In these tumors, we consistently observed a down regulation of galectin-3 expression related to increased aggressiveness. Galectin-3 belongs to a family of galactose-binding lectins and binds laminin through its numerous poly-N-acetyllactosamine chains. To date, the exact role of galectin-3 in the complex interactions between cancer cells and laminin has not been clearly defined. Adhesion of melanoma cells to laminin is a critical event during tumor invasion and metastasis. In this study, we explore the possibility that galectin-3 could modulate attachment of two human melanoma cell lines to laminin. A2058 and A375 melanoma cell expressed galectin-3 on their surface as demonstrated by immunofluorescence, and attached to laminin in an in vitro assay. We demonstrate that neither recombinant galectin-3 nor an affinity purified antigalectin-3 antiserum altered adhesion of A2058 or A375 melanoma cells to laminin. Our data strongly suggest that galectin-3 is not a key element in adhesion of the melanoma cells to laminin. These results are not surprising in light of the observation that galectin-3 expression is down regulated in cancer and that increased adhesion to laminin is a constant feature of invasive cancer cells. [less ▲]

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See detailCancers épithéliaux de l'ovaire. Acquisitions récentes
van den Brule, F. A.; Lambotte, René ULg; Castronovo, Vincenzo ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1995), 24(3), 241-52

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by ... [more ▼]

Ovarian carcinomas constitute the major cause of the mortality and morbidity in gynaecology. Most ovary carcinomas are epithelial tumours. Our understanding of ovarian cancerogenesis has been hampered by the lack of a well defined precursor lesion, the lack of knowledge about tumour progression, and by the relative inaccessibility of the ovaries in the abdominal cavity. Recent studies using experimental models allow us to better define the fundamental mechanisms of carcinogenesis from the serous ovarian cells and of invasion of the abdominopelvic cavity by proximity. This review article tries to update on epidemiology, genetic syndromes, biology, screening, and therapy of these epithelial tumours, and about the new directions taken by basic and clinical research. We will present data concerning oncogenes and tumour suppressor genes involved in epithelial ovarian tumours, regulation of tumour cells by growth factors, genes involved in tumour invasion, and mechanisms used by the cancer cell to resist to therapies. Non-epithelial ovarian tumours will not be examined in this manuscript. [less ▲]

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See detailLa naissance de l'écriture au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailLe méthotrexate en rhumatologie: une révolution thérapeutique
Kaye, O.; Ribbens, Clio ULg; Hauwaert, Christian ULg et al

in Revue Médicale de Liège (1995), 50(11), 453-457

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