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See detailNew Basic Membrane-Destabilizing Peptides For Plasmid-Based Gene Delivery In Vitro And In Vivo
Rittner, K.; Benavente, A.; Bompard-Sorlet, A. et al

in Molecular Therapy (2002), 5(2), 104-14

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind ... [more ▼]

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind to nucleic acids and destabilize liposomes consisting of 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) and cholesterol (3:1 mol/mol) at pH 5 and pH 7. Complexes of plasmid DNA and ppTG1 gave rise to efficient transfection in a variety of human and murine cell lines at low charge ratios ([+/-] between 1 and 2). In cell culture experiments, such vectors were superior to the membrane-destabilizing peptide KALA. In comparison with cationic lipid-, dendrimer-, and polymer-based transfection agents like Superfect, polyethylenimine (PEI), and Lipofectin, ppTG1 vectors showed good transfection efficiencies, especially at low DNA doses. Moreover, we demonstrated for the first time successful gene transfer in living animals with a single-component peptide vector. In the mouse, intravenous injection of a luciferase expression plasmid complexed with ppTG1 or ppTG20 led to significant gene expression in the lung 24 hours after injection. Structure-function studies with ppTG1, ppTG20, and sequence variants suggest that the high gene transfer activity of these peptides is correlated with their propensity to exist in alpha-helical conformation, which seems to be strongly influenced by the nature of the hydrophobic amino acids. [less ▲]

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See detailLe changement de sexe : perspectives pronostiques
Michel, Aude; Mormont, Christian ULg

in Neuropsy News (2002), 1(5), 224-231

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See detailDes doutes nes apres le 11 septembre aux espoirs places dans l'euro....
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(1), 1-2

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See detailHuman recombinant erythropoietin and quality of life: a wonder drug or something to wonder about?
Bottomley, A.; Thomas, R.; Van Steen, Kristel ULg et al

in Lancet Oncology (2002), 3(3), 145-53

Over the past decade an increasing number of studies have supported the use of recombinant human erythropoietin (epoetin) in cancer patients, suggesting that it improves haemoglobin concentrations for ... [more ▼]

Over the past decade an increasing number of studies have supported the use of recombinant human erythropoietin (epoetin) in cancer patients, suggesting that it improves haemoglobin concentrations for some. There is also evidence that this treatment may lead to improvement in quality of life for cancer patients. This systematic review examines the issue. We identified and critically reviewed 13 trials. Although some of the results indicate that epoetin has positive effects on quality of life, methodological limitations inherent in most of the studies hamper interpretation of data. Evidence from this review suggests that more robust designs are required to show any significant quality-of-life benefits for cancer patients undergoing epoetin treatment. [less ▲]

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See detailLe contrat de travail et la signature électronique
Kefer, Fabienne ULg; Barth, H.

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2002)

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See detailApproche diagnostique de la dissection carotidienne. A propos de deux cas.
Deflandre, E.; Tshibanda, L.; NCHIMI LONGANG, Alain ULg et al

in Revue Médicale de Liège (2002), 57(2), 85-90

Two cases of acute internal carotid dissection are presented. Typical symptoms, pathogeny and imaging features are reviewed. Magnetic Resonance is actually the best technique for the diagnosis of internal ... [more ▼]

Two cases of acute internal carotid dissection are presented. Typical symptoms, pathogeny and imaging features are reviewed. Magnetic Resonance is actually the best technique for the diagnosis of internal carotid artery dissection, which should be searched in young patients presenting neurologic and cervico-facial symptoms. [less ▲]

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See detailGlacial-interglacial changes of continental weathering: estimates of the related CO2 and HCO3- flux variations and their uncertainties
Munhoven, Guy ULg

in Global and Planetary Change (2002), 33(1-2), 155-176

A range of estimates for the glacial-interglacial variations in CO, consumption and HCO3- production rates by continental weathering processes were calculated with two models of continental weathering ... [more ▼]

A range of estimates for the glacial-interglacial variations in CO, consumption and HCO3- production rates by continental weathering processes were calculated with two models of continental weathering: the Gibbs and Kump Weathering Model (GKWM) [Paleoceanography 9(4) (1994) 529] and an adapted version of Amiotte Suchet and Probst's Global Erosion Model for CO2 Consumption (GEM-CO2) [C. R, Acad. Sci. Paris, Ser. 11317 (1993) 615; Tellus 47B (1995) 273]. Both models link CO2 consumption and HCO3- production rates to the global distributions of lithology and runoff. A spectrum of 16 estimates for the runoff distribution at the Last Glacial Maximum (LGM) was constructed on the basis of two different data sets for present-day runoff and climate results from eight GCM climate simulation experiments carried out in the framework of the Paleo Modelling Intercomparison Project (PMIP). With these forcings, GKWM produced 3.55-9.0 Tmol/year higher and GEM-CO2 4.7-13.25 Tmol/year higher global HCO3- (1 Tmol=10(12) mol) production rates at the LGM, Mean variations (plus/minus one standard error of the mean with 7 df) were 6.2+/-0.6 and 9.4+/-1.0 Tmol/year, respectively. The global CO2 consumption rates obtained with GKWM were 1.05-4.5 Tmol/year (mean: 2.8+/-0.4 Tmol/year) higher at the LGM than at present. With GEM-CO2 this increase was 1.95-7.15 Tmol/year (mean: 4.8+/-0.6 Tmol/year). The large variability in the changes obtained with each weathering model was primarily due to the variability in the GCM results. The increase in the CO2 consumption rate due to continental shelf exposure at the LGM was always more than 60% larger than its reduction due to ice cover. For HCOT production rates, the increase related to shelf exposure was always more than twice as large as the decrease due to ice cover. Flux variations in the areas exposed both now and at the LGM were, in absolute value, always more than 3.5 times lower than those in the shelf environment. The calculated CO2 consumption rates by carbonate weathering were consistently higher at the LGM, by 2.45-4.5 Tmol/year (mean: 3.4+/-0.2 Tmol/year) according to GKWM and by 2.75-6.25 Tmol/year (mean: 4.6+/-0.4 Tmol/year) according to GEM-CO, For silicate weathering, GKWM produced variations ranging between a 1.9 Tmol/year decrease and a 0.4 Tmol/year increase for the LGM (mean variation: -0.7+/-0.2 Tmol/year); GEM-CO, produced variations ranging between a 0.8 Tmol/year decrease and a 1.05 Tmol/year increase (mean variation: +0.2+/-0.2 Tmol/year). In the mean, the calculated variations of CO2 and HCO3- fluxes would contribute to reduce atmospheric p(CO2) by 5.7+/-1.3 ppmv (GKWM) or 3 12.1+/-1.7 ppmv (GEM-CO2), which might thus represent a non-negligible part of the observed glacial interglacial variation of similar to 75 ppmv. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailRecent developments in infectious bovine rhinotracheitis
Thiry, Etienne ULg; Lemaire, Mylène; Keuser, Véronique et al

in Cattle Practice (2002), 10

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See detailResearch on Instruction in Physical Education. Review of the Research in Selected Roman Languages.
Piéron, Maurice ULg; Cloes, Marc ULg

in International Journal of Physical Education (2002), 39(1), 12-20

In French, the term "intervention" is used since a few years. The paper will: (1) deal with the topic of instruction limites to teachers' decisions and interventions during the interactive phase in ... [more ▼]

In French, the term "intervention" is used since a few years. The paper will: (1) deal with the topic of instruction limites to teachers' decisions and interventions during the interactive phase in teaching; during this phase, activities planned in the pre-interactive phase are implemented: the interactive phase concerns the task's presentation, the pupils' activity and the control of this activity in terms of behavioural management and of the quality of the eprformance (feedback); (2) refer to the main research methods used in gathering data, and (3) develop the main findings in the domain of instruction: teacher thinking and behaviour, pupils' thoughts and behaviour, management of the class or in other words control of pupils' behaviour. It is evident that thougts and behaviours are closely related and are part of the relationship between teachers and pupils. The paper focused only on texts appearing in French, Portuguese and Spanish published since 1997 in Physical eeducation journals and Proceeddings of international congresses. [less ▲]

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See detailEstimating effects of permanent environment, lactation stage, age, and pregnancy on test-day yield.
Bormann, J.; Wiggans, G. R.; Philpot, J. C. et al

in Journal of Dairy Science (2002), 85(1), 2631-26321

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See detailFirst synthesis of a '1,2-diquinone-calix[4]arene'. Interaction of its reduced form with Ag+
Vataj, Rame; Ridaoui, Hassan; Louati, Alain et al

in Journal of Electroanalytical Chemistry (2002), 519(1-2), 123129

Electrochemical oxidation of 5,11,17,23-tetra-tert-butyl-25,26-bis(diphenylphosphinoylmethoxy)-27,28-dihydroxycalix[4]arene (3), a calixarene with two phosphoryl units appended on proximal positions ... [more ▼]

Electrochemical oxidation of 5,11,17,23-tetra-tert-butyl-25,26-bis(diphenylphosphinoylmethoxy)-27,28-dihydroxycalix[4]arene (3), a calixarene with two phosphoryl units appended on proximal positions, affords the corresponding '1,2-diquinonecalix[4]arene' (4). The formation of 4 results from nucleophilic attack of residual water on anodically generated diphenoxylium. cations. Preliminary voltammetric experiments in CH3CN on a platinum electrode showed that 4 is suitable for electrochemical detection of the silver metal cation. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailLes "sans-papiers" et les régularisations dans l'Union Européenne à la lumière du cas belge
Martiniello, Marco ULg

in Revue des Affaires Européennes (2002), 11ème-12ème Année

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See detailDetection Of Apple Chlorotic Leaf Spot Virus Using A 5 ' Nuclease Assay With A Fluorescent 3 ' Minor Groove Binder-Dna Probe
Vendrame, Marina; Kummert, Jean; Lepoivre, Philippe ULg et al

in Journal of Virological Methods (2002), 104(1), 99-106

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See detailQuelques considérations techniques sur la construction, les transformations et l'état matériel de la tour valenciennoise, à Mons
Houbart, Claudine ULg

in Mémoires et Publications de la Société des Sciences, des Arts et des Lettres du Hainaut (2002), CI

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See detailNSAIDS : not just COX-2 inhibitors ?
Henrotin, Yves ULg

in Intern Clin Pract Series (2002), 19

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See detailLe médecin du travail face au harcèlement moral au travail : constats et prespectives
Gruslin, Isabelle ULg; Italiano, Patrick ULg; Faulx, Daniel ULg

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2002), 39(2), 61-68

L'article de D. Faulx et C. Geuzaine, paru dans le numéro 3-2000 de cette revue, aborde l'étendue du phénomène du harcèlement moral ainsi que les aspects juridiques de la définition, la description du ... [more ▼]

L'article de D. Faulx et C. Geuzaine, paru dans le numéro 3-2000 de cette revue, aborde l'étendue du phénomène du harcèlement moral ainsi que les aspects juridiques de la définition, la description du processus, ses conséquences médicales et les facteurs de risque. Dans la suite de cette étude, nous présentons ici les résultats d'une enquête menée auprès des médecins du travail, en tant que témoins et intervenants privilégiés dans le domaine du harcèlement. Cette enquête vise à apporter des informations descriptives originales concernant les attitudes, les opinions et représentations des médecins du travail par rapport au phénomène de harcèlement moral. En outre, elle est l'occasion de tester une série d'hypothèses sur les facteurs pouvant influencer l'attitude des médecins du travail vis-à-vis du harcèlement moral. [less ▲]

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See detailWater fluxes at an ocean margin in the presence of a submarine canyon
Skliris, Nikolaos ULg; Hecq, Jean-Henri ULg; Djenidi, Salim ULg

in Journal of Marine Systems (2002), 32(1-3), 239-251

A 3-D, unsteady, nonlinear, high-resolution model is used to estimate shelf/slope exchanges through Calvi Canyon (NW Corsica, Mediterranean Sea) in various regimes of stratification and wind patterns. To ... [more ▼]

A 3-D, unsteady, nonlinear, high-resolution model is used to estimate shelf/slope exchanges through Calvi Canyon (NW Corsica, Mediterranean Sea) in various regimes of stratification and wind patterns. To evaluate the alongshore and cross-shore fluxes within the canyon area as well as the water exchanges between the canyon and Calvi Bay, volume transports are computed at the sides of two closed, interconnected boxes encompassing the canyon on the shelf and slope domains. Model results show that water transports between Calvi Bay and the open sea are determined by flow modifications in the canyon area. The mean horizontal flow deviates southwestward upstream of the canyon, generating an onshore transport in the western part of Calvi Bay. Within the canyon, the circulation is cyclonic and is responsible for an offshore transport downstream of the canyon and in the eastern part of the bay. The effect of stratification is shown to limit the vertical extent of the influence of canyon topography so that the alongshore flow above the canyon is quasi-undisturbed in strong stratified conditions, resulting in weak cross-shore exchange. Wind events are shown to be responsible for a strong increase of cross-shore transports between the bay and the canyon area. (C) 2002 Elsevier Science B.V All rights reserved. [less ▲]

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See detailMetapopulation dynamics of the bog fritillary butterfly: Modelling the effect of habitat fragmentation
Sawchik, J.; Dufrêne, Marc ULg; Lebrun, Philippe et al

in Acta Oecologica (2002), 23(5), 287-296

Population viability analysis (PVA) and metapopulation theory are valuable tools to model the dynamics of spatially structured populations. In this article we used a spatially realistic population dynamic ... [more ▼]

Population viability analysis (PVA) and metapopulation theory are valuable tools to model the dynamics of spatially structured populations. In this article we used a spatially realistic population dynamic model to simulate the trajectory of a Proclossiana eunomia metapopulation in a network of habitat patches located in the Belgian Ardenne. Sensitivity analysis was used to evaluate the relative influence of the different parameters on the model output. We simulated habitat loss by removing a percentage of the original habitat, proportionally in each habitat patch. Additionally, we evaluated isolation and fragmentation effects by removing and dividing habitat parches from the network, respectively. The model predicted a slow decline of the metapopulation size and occupancy. Extinction risks predicted by the model were highly sensitive to environmental stochasticity and carrying capacity. For a determined level of habitat destruction, the expected lifetime of the metapopulation was highly dependent on the spatial configuration of the landscape. Moreover, when the proportion of removed habitat is above 40% of the original habitat, the loss of whole patches invariably leads to the strongest reduction in metapopulation viability. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. [less ▲]

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See detailBPDZ 154 Activates Adenosine 5’-Triphosphate-Sensitive Potassium Channels; In Vitro Studies Using Rodent Insulin-Secreting Cells and Islets Isolated from Patients with Hyperinsulinism
Cosgrove, K. E.; Antoine, M.-H.; Lee, A. T. et al

in Journal of Clinical Endocrinology and Metabolism (2002), 87

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See detailQuelques résultats prometteurs pour une sylviculture de l'Aulne glutineux en Wallonie.
Claessens, Hugues ULg; Thibaut, A.; Rondeux, Jacques ULg

in Revue Forestière Française (2002), 54(3), 259-270

In Belgium, black alder is well known for its ecological functions, but is generally considered as a secondary species without any true economic value. The present study, based on data pertaining to 166 ... [more ▼]

In Belgium, black alder is well known for its ecological functions, but is generally considered as a secondary species without any true economic value. The present study, based on data pertaining to 166 plots, aims at evaluating the potential of black alder silviculture in the Walloon forest (Southern Belgium). We successively analysed dominant height growth, dominant girth growth and solid stem volume over time. It appears that by controlling competition within stands it should be possible to produce quality, 150-cm girth logs within 50 – 100 years, depending on the level of productivity. The German tables of Mitscherlich (in Schöber, 1975) seem to be most suitable for describing the growth parameters of the Belgian alder stands over time and black alder stand production can be estimated at 3 to 9 m3/ha/year according to site classes. We can conclude that black alder silviculture can be a viable economic activity. [less ▲]

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See detailThe Use of Cardboard Bedding Material as Part of an Environmental Control Regime for Heaves-affected Horses: In Vitro Assessment of Airborne Dust and Aeroallergen Concentration and In Vivo Effects on Lung Function
Kirschvink, Nathalie; Di silvestro, F.; Sbai, Ilham ULg et al

in Veterinary Journal (2002), 163

This study aimed to test whether shredded cardboard is an appropriate minimum-dust bedding material for heaves-affected horses. Results of standardized in vitro measurement of airborne dust and ... [more ▼]

This study aimed to test whether shredded cardboard is an appropriate minimum-dust bedding material for heaves-affected horses. Results of standardized in vitro measurement of airborne dust and aeroallergen concentrations of cardboard bedding were significantly lower than those of common bedding materials. Six heaves-affected horses in clinical remission after pasturing were stabled for two months on cardboard bedding and fed grass silage. Pulmonary function tests (PFT: ventilatory mechanics, arterial blood gases, airway inflammation scoring, bronchoalveolar cytology) were performed before, during and after this period and after stabling the horses in poor hygienic conditions. PFT values measured during and after the stabling period on cardboard bedding were not significantly different from those recorded after the period at pasture or from those of healthy horses, but were significantly different from those recorded in poor hygienic conditions. On basis of the in vitro and in vivo results it can be concluded that cardboard bedding, used in conjunction with low-dust forage, may be appropriate in the provision of minimum-dust management of heaves-affected horses [less ▲]

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See detailCompte-rendu de l'ouvrage de D. Cardon : La Draperie au Moyen Age. Essor d'une grande industrie européenne
Xhayet, Geneviève ULg

in Revue d'Histoire des Sciences (2002), 55(4), 560-561

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See detailLa loi du 17 avril 2002 instaurant la peine de travail comme peine autonome en matière correctionnelle et de police
Jacobs, Ann ULg; Dantinne, Michaël ULg

in Revue de Droit Pénal et de Criminologie (2002)

Présentation et analyse juridique et criminologique de la loi du 17 avril 2002 introduisant la peine de travail en droit belge.

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See detailBa distribution in surface Southern Ocean sediments and export production estimates
Fagel, Nathalie ULg; Dehairs, Frank; André, Luc ULg et al

in Paleoceanography (2002), 17(2, MAR-JUN),

[1] We present excess Ba (Baxs) data (i.e., total Ba corrected for lithogenic Ba) for surface sediments from a north-south transect between the Polar Front Zone and the northern Weddell Gyre in the ... [more ▼]

[1] We present excess Ba (Baxs) data (i.e., total Ba corrected for lithogenic Ba) for surface sediments from a north-south transect between the Polar Front Zone and the northern Weddell Gyre in the Atlantic sector and between the Polar Front Zone and the Antarctic continent in the Indian sector. Focus is on two different processes that affect excess Ba accumulation in the sediments: sediment redistribution and excess Ba dissolution. The effect of these processes needs to be corrected for in order to convert accumulation rate into vertical rain rate, the flux component that can be linked to export production. In the Southern Ocean a major process affecting Ba accumulation rate is sediment focusing, which is corrected for using excess Th-230. This correction, however, may not always be straightforward because of boundary scavenging effects. A further major process affecting excess Ba accumulation is barite dissolution during exposure at the sediment-water column interface. Export production estimates derived from excess Th-230 and barite dissolution corrected Baxs accumulation rates (i.e., excess Ba vertical rain rates) are of the same magnitude but generally larger than export production estimates based on water column proxies (Th-234-deficit in the upper water column; particulate excess Ba enrichment in the mesopelagic water column). We believe export production values based on excess Ba vertical rain rate might be overestimated due to inaccurate assessment of the Baxs preservation rate. Barite dissolution has, in general, been taken into account by relating it to exposure time before burial depending on the rate of sediment accumulation. However, the observed decrease of excess Ba content with increasing water column depth (or increasing hydrostatic pressure) illustrates the dependence of barite preservation on degree of saturation in the deep water column in accordance with available thermodynamic data. Therefore correction for barite dissolution would not be appropriate by considering only exposure time of the barite to some uniformly undersaturated deep water but requires also that regional differences in degree of undersatuation be taken into account. [less ▲]

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See detailMétastase synoviale d'un cancer colique se présentant comme une arthrite du genou. Caractérisation par tomographie à émission de positons au 18FDG
Beckers, C.; Foidart, J.; Thiry, Albert ULg et al

in Revue Médicale de Liège (2002), 57(5), 467-474

A case of carcinomatous monoarthritis involving the left knee due to colonic adenocarcinoma is described. Large recurrent synovial effusion, that will be later hematic, lytic lesion of the bones and ... [more ▼]

A case of carcinomatous monoarthritis involving the left knee due to colonic adenocarcinoma is described. Large recurrent synovial effusion, that will be later hematic, lytic lesion of the bones and chondrolysis were noted. Knee positron emitting tomography scan using FDG (FDG-PET) revealed a diffuse increased uptake in soft tissues assumed to be synovium, the hypertrophy of which was identified by ultrasonography. Whole body PET scan showed extensive lymph node, visceral and bone metastases, suggesting that the increase in the synovium could also be of metastatic origin. The final diagnosis of synovial carcinomatosis secondary to the known colonic adenocarcinoma was confirmed by histological analysis of biopsies obtained by arthroscopy. A review of the literature is realised. To our knowledge, this is the first synovial metastasis studied by FDG-PET. [less ▲]

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See detailDélinquance et suicide? Un défi pour l'aide à la jeunesse
Malchair, Alain ULg

in Actes du 2ème Congrès international de la Francophonie et Prévention du suicide (2002)

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See detailCoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.
Piret, Jean-Pascal; Mottet, Denis ULg; Raes, Martine et al

in Annals of the New York Academy of Sciences (2002), 973

HIF-1 (hypoxia-inducible factor-1) is the major transcription factor that is specifically activated during hypoxia. This transcription factor is composed of two subunits: HIF-1alpha and ARNT (aryl ... [more ▼]

HIF-1 (hypoxia-inducible factor-1) is the major transcription factor that is specifically activated during hypoxia. This transcription factor is composed of two subunits: HIF-1alpha and ARNT (aryl hydrocarbon receptor nuclear translocator). ARNT is constitutively expressed, whereas HIF-1alpha is targeted to proteasome degradation by ubiquitination during normoxia. In hypoxia, HIF-1alpha is stabilized and translocates to the nucleus, where it binds to ARNT. The active HIF-1 induces expression of various genes whose products play an adaptive role to the new conditions induced by hypoxia. Besides the role played by HIF-1 in the adaptation to hypoxia, recent data describe a possible role for HIF-1 in the modulation of apoptosis. According to some authors, hypoxia induces apoptosis. However, it has also been reported that hypoxia could protect cells against apoptotic cell death induced by various agents such as serum deprivation and incubation in the presence of chemotherapy agents. These contradictory data suggest that HIF-1 could display either a proapoptotic or an antiapoptotic role according to the conditions. In order to study how HIF-1 can modulate apoptosis, we studied whether hypoxia or cobalt chloride, a chemical inducer of HIF-1, could influence apoptosis induced by tert-butyl hydroperoxide (t-BHP), serum deprivation, or both in hepatoma cell line HepG2. HepG2 cells were incubated 8 hours under normoxia or hypoxia in the presence of t-BHP with or without CoCl2. CoCl2 reduced the apoptotic death of HepG2 cells induced by t-BHP and serum deprivation, as measured by DNA fragmentation. This effect was confirmed by measurement of the caspase activity. Moreover, hypoxia also prevented t-BHP- or serum deprivation-induced DNA fragmentation and caspase activation-however, to a lower extent than CoCl2. These different data suggest a possible antiapoptotic role of HIF-1. More experiments are needed to define if HIF-1 actually plays an active role in cell death protection and to determine the exact mechanism underlying this effect. [less ▲]

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See detailBeyond a glimpse at seasonal dry skin. A review.
Franchimont, Claudine ULg; Pierard, Gérald ULg

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

On clinical grounds the so-called dry skin corresponds in reality to a rough sometimes flaky and scaly stratum corneum. The spectrum of xerotic disorders is quite large encompassing diverse etiologies and ... [more ▼]

On clinical grounds the so-called dry skin corresponds in reality to a rough sometimes flaky and scaly stratum corneum. The spectrum of xerotic disorders is quite large encompassing diverse etiologies and physiopathological pathways. The clinical assessment of these conditions relies on close visual and tactile inspection. EEMCO guidances were proposed in this field for subject and expert evaluations. Scoring systems include analogue scales, the overall dry skin score (ODS) and the SRRC score combining the grading of scaliness, roughness, redness and cracks. The dry skin extent area and severity index (DASI) is defined for the dermatological evaluation of the entire body surface. The use of a video camera equipped with an internal ultraviolet light illumination unit is very informative and allows better comparative assessments. [less ▲]

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See detailStunting may determine the severity of malaria-associated anemia in African children.
Verhoef, Hans; West, Clive E; Veenemans, Jacobien et al

in Pediatrics (2002), 110(4), 48

OBJECTIVE: Evidence from previous studies that malnourished children are protected against malaria is controversial. In individuals repeatedly exposed to malaria, immunity may develop first against severe ... [more ▼]

OBJECTIVE: Evidence from previous studies that malnourished children are protected against malaria is controversial. In individuals repeatedly exposed to malaria, immunity may develop first against severe disease, then against pyrogens, and last, against parasites. If this is true, this would suggest that reduced immune function that may exist in stunted children exacerbates the severity of malarial signs and symptoms, rather than the occurrence of parasitemia. On the other hand, several studies have suggested that malnourished children are protected to some degree against malaria. Our aim was to evaluate whether observational data support the hypothesis that nutritional inadequacies that cause stunting modify the associations between malaria and hematologic indicators such as hemoglobin concentration and serum concentrations of C-reactive protein and soluble transferrin receptor (sTfR). We showed earlier that increased serum concentrations of these receptors in asymptomatic malaria may be explained, at least in part, by increased erythropoiesis to compensate for malaria-induced hemolysis. METHODOLOGY: Community-based cluster survey among Kenyan children aged 2 to 36 months asymptomatic for malaria or anemia (n = 318). RESULTS: When adjusted for age and wasting, the malaria-associated decrease in mean hemoglobin concentration was 8.5 g/L and 15.8 g/L in nonstunted and stunted children, respectively. The malaria-associated increase in geometric mean serum concentrations of sTfR was 1.1-fold and 1.8-fold in nonstunted and stunted children, respectively. The malaria-associated increase in geometric mean serum concentrations of C-reactive protein was 1.4-fold and 2.3-fold in nonstunted and stunted children, respectively. Thus, children with malaria and those who were stunted suffered from more severe anemia and had higher serum concentrations of C-reactive protein and sTfR than would be expected from the combined effect of the 2 working independently. CONCLUSIONS: Our results are consistent with the notion that the nutritional inadequacies causing stunting also impair host immunity, thus increasing the degree to which malaria is associated with decreased concentrations of hemoglobin, with increased inflammation, and with increased iron demand in developing erythroblasts. Increased intake of micronutrients may not only reduce stunting and nutritional anemia, but also reduce malaria-associated anemia. [less ▲]

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See detailCharacterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium.
Aendekerk, Severine; Ghysels, Bart ULg; Cornelis, Pierre et al

in Microbiology (Reading, England) (2002), 148(Pt 8), 2371-81

Vanadium has an antibacterial activity against Pseudomonas aeruginosa, especially under conditions of iron limitation. Some degree of resistance to V is inducible by prior exposure to the metal. One ... [more ▼]

Vanadium has an antibacterial activity against Pseudomonas aeruginosa, especially under conditions of iron limitation. Some degree of resistance to V is inducible by prior exposure to the metal. One mutant (VS1) with a higher sensitivity to V was obtained by transposon mutagenesis of P. aeruginosa PA 59.20, a clinical isolate. This mutant had an insertion in a non-coding region, upstream of a cluster of four genes. Three of them show similarities to genes corresponding to known P. aeruginosa antibiotic efflux systems, including an efflux protein, a membrane fusion protein and an outer-membrane porin. This cluster was named mexGHI-opmD. By allelic exchange, three mutants, ncr (for non-coding region), mexI and opmD were constructed in P. aeruginosa PAO1. Next to V sensitivity, the ncr, mexI and opmD mutants also showed reduced production of elastase, rhamnolipids, pyocyanine, pyoverdine and had reduced swarming motility, phenotypes that are known to be regulated by quorum sensing. All wild-type phenotypes, including growth in the presence of V, were restored by complementation with the complete cluster. The production of N-acyl-homoserine lactones (AHLs) was detected using the Chromobacter violaceum bioassay. Total extracts from the three mutants failed to induce the production of violacein by C. violaceum, although AHLs were detected by TLC and C. violaceum overlay. Violacein production was restored by complementation with mexGHI-opmD. The opmD mutant grew very slowly in LB or CAA medium, indicating that OpmD has an important physiological function for the cell. In conclusion, it is believed that the MexGHI-OpmD pump is probably involved in AHL homeostasis in P. aeruginosa. [less ▲]

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See detailTexture evolution during deep-drawing processes
Duchene, Laurent ULg; Godinas, A.; Cescotto, Serge ULg et al

in Journal of Materials Processing Technology (2002), 125-126

This paper presents a constitutive law based on Taylor’s model implemented in our non-linear finite element code LAGAMINE. The yield locus is only locally described and a particular interpolation method ... [more ▼]

This paper presents a constitutive law based on Taylor’s model implemented in our non-linear finite element code LAGAMINE. The yield locus is only locally described and a particular interpolation method has been developed. This local yield locus model uses a discrete representation of the material’s texture. The interpolation method is presented and a deep-drawing application is simulated in order to show up the influence of the texture evolution during forming processes. [less ▲]

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See detailLong-pulsed ruby laser-assisted hair removal in male-to-female transsexuals.
Paquet, Philippe ULg; Fumal, I.; Pierard, Claudine ULg et al

in Journal of Cosmetic Dermatology (2002), 1(1), 8-12

BACKGROUND: Unwanted male-pattern pilosity is a heavy psychological burden and can cause distress for male-to-female transsexuals. Orchidectomy and oestrogen supplementation combined with antiandrogens ... [more ▼]

BACKGROUND: Unwanted male-pattern pilosity is a heavy psychological burden and can cause distress for male-to-female transsexuals. Orchidectomy and oestrogen supplementation combined with antiandrogens fail to make hair disappear. AIMS: To study the effect of long-pulsed ruby laser treatment. RESULTS: Hair density was successfully abated on the beard and chest of three male-to-female transsexuals. A lingering effect over 6 months with a 50-90% hair density reduction was obtained. CONCLUSION: Photothermolysis using the long-pulsed ruby laser is a promising, well-tolerated method of hair removal in male-to-female transsexuals under oestrogen supplementation and antiandrogens. [less ▲]

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See detailEffect of instillation into lung of autologous blood on pulmonary function and tracheobronchial wash cytology
Art, Tatiana ULg; Tack, S.; Kirschvink, Nathalie et al

in Equine Veterinary Journal. Supplement (2002), 34

This study aimed at measuring the functional consequences and the pulmonary cytology changes following a simulation of pulmonary haemorrhage. Pulmonary function tests including lobeline-induced ... [more ▼]

This study aimed at measuring the functional consequences and the pulmonary cytology changes following a simulation of pulmonary haemorrhage. Pulmonary function tests including lobeline-induced hyperventilation, cytology of tracheo-bronchial wash (TBW) and thoracic radiographs were performed before, as well as 1, 7, 14 and 28 days after, the instillation of 300 ml of blood into the lungs of 4 horses deemed free of exercise-induced pulmonary haemorrhage (Group 1). Control data (Group 2) were obtained by instilling the same volume of saline into the lungs of the same horses in a crossover design (control). The instillation of blood or saline resulted in an increase in the number of neutrophils in the TBW. Thoracic radiographs showed increased opacity in the caudodorsal region of the lungs in 4/4 (Day 1) and 2/4 horses (Day 7), in Group 1, and in 2/4 (Day 1) and 0/4 horses (Day 7) in the control group. These changes were attributed to the instillation procedure rather than the nature of the instilled material. Breathing mechanics and arterial blood gases at rest were not affected in either Groups 1 or 2. However, the maximal expiratory peak flow recorded during lobeline-induced hyperventilation was significantly lower (P<0.05) and the total pulmonary resistance significantly higher (P<0.05) on Day 1 in Group 1, but not Group 2. These observations suggest that expiratory flows might be partly limited in bleeders when breathing at high airflow [less ▲]

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See detailMigraines et vertiges, une relation à vous faire tourner la tête
FUMAL, Arnaud ULg; Schoenen, Jean ULg

in Migraine Contact (2002), 2

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See detailDe la philosophie à la sociologie en compagnie de Pierre Bourdieu
Frère, Bruno ULg

in Revue de l'Institut de Sociologie (2002), 1-4

La compréhension adéquate des influences de Pierre Bourdieu peuvent nous permettre de diversifier sa pensée comme il diversifiait lui-même celle des autres. On sait qu’il utilise Wittgenstein dès l ... [more ▼]

La compréhension adéquate des influences de Pierre Bourdieu peuvent nous permettre de diversifier sa pensée comme il diversifiait lui-même celle des autres. On sait qu’il utilise Wittgenstein dès l'élaboration de son vocabulaire critique défiant les « prénotions » et les préjugés condamnés comme étant le fruit d'une sociologie spontanée et profane qui mine le jugement objectif. Mais il le quitte au moment où celui-ci manifeste le désir de revenir « au point de vue du sens commun ». Il semble bien que nous ayons alors affaire à « une quête fervente de l'ordinaire et du familier » à laquelle Bourdieu ne se référera plus.. En tenir compte peut nous permettre d’ouvrir le dialogue avec la sociologie pragmatique de Luc Boltanski et Laurent Thévenot. A la suite de Bourdieu, c’est alors en partie avec eux qu’on peut prolonger véritablement l’exigence wittgensteinienne : étudier les « exemples primitifs des langages communs ». Ces sociologies, on le sait, accueillent a priori le discours des acteurs comme le fruit d’un travail interprétatif cohérent. Qu’ils soient « justes » ou non par rapport à l’état du monde n’est pas l’essentiel. L’enjeu n’est plus d’évaluer leur valeur de vérité par rapport à la réalité - ce qu’autorise la pensée de Bourdieu - mais d’approcher « des sujets parlants ordinaires [… ]co-énonciateurs du discours intervenant en permanence dans la construction du sens » . Tous sont capables de construire et de déconstruire leurs pratiques et ce jeu de construction-déconstruction revêt un intérêt en soi. Il s’agit moins de nier le fait qu’un langage quelconque puisse être pétri d’illusions que de chercher à en saisir la portée significative. En définitive, les objectifs de ces paradigmes sont à la fois différents et tout à fait complémentaires. Il faut à présent chercher à saisir correctement les objets sociologiques ambigus qu’une sociologie hybride permettrait d’éclairer. C'est ce que nous nous suggérons de le présent article. [less ▲]

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See detailBulletin bibliographique de la Société Rencesvals, 2001-2002
Henrard, Nadine ULg

in Bulletin bibliographique de la Société Rencesvals (2002), (33), 1-179

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See detailStability of recombinant 2 S albumin allergens in vitro
Murtagh, Gareth; Dumoulin, Mireille ULg; Alcocer, Marcos et al

in Biochemical Society Transactions (2002), 30

Two well known 2 S albumins, Ber e 1 from brazil nut and sunflower 2 S albumin 8 (SFA-8), have been expressed in a eukaryotic system and purified. Analysis of recombinant versions of Ber e 1 and SFA-8 ... [more ▼]

Two well known 2 S albumins, Ber e 1 from brazil nut and sunflower 2 S albumin 8 (SFA-8), have been expressed in a eukaryotic system and purified. Analysis of recombinant versions of Ber e 1 and SFA-8 revealed them to be significantly more resistant to digestion by pepsin than BSA, and to be stable for up to 30 min in simulated gastric fluid. Unfolding monitored by CD indicated that both proteins were also very resistant to denaturation induced by heat and low pH. These results suggest that, although the ability of 2 S albumins to reach the circulatory system may be a prerequisite for the allergenicity of this group of proteins, stability is just one of a number of characteristics that provoke a selective immune response. [less ▲]

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See detailSynthetic, structural, magnetic, and Mossbauer spectral study of {Fe[HC(3,5-Me(2)pz)(3)](2)}I-2 and its spin-state crossover behavior
Reger, D. L.; Little, C. A.; Smith, M. D. et al

in European Journal Of Inorganic Chemistry (2002), (5), 1190-1197

The complex {Fe[HC(3,5-Me(2)pz)(3)](2)}I-2 (1) has been prepared from the reaction of FeI2 and HC(3,5-Me(2)pz)(3) (pz = pyrazolyl ring) in a 1:2 ratio. The complex is high-spin in both the solid state and ... [more ▼]

The complex {Fe[HC(3,5-Me(2)pz)(3)](2)}I-2 (1) has been prepared from the reaction of FeI2 and HC(3,5-Me(2)pz)(3) (pz = pyrazolyl ring) in a 1:2 ratio. The complex is high-spin in both the solid state and in solution at ambient temperature, In the solid state, magnetic susceptibility and Mossbauer spectral studies indicate that samples of the complex that have been crystallized and dried change completely from high-spin to low-spin upon cooling below 195 K, with a substantial two-step thermal hysteresis in the transition, The spin-crossover properties of I are sample dependent: powder samples do not change to low-spin at low temperatures. Two crystalline forms of I have been identified by X-ray crystallography, one form containing no solvent of crystallization and the other containing solvent, In both, there is only one iron site, with average Fe-N bond lengths of 2.18 and 2.17 Angstrom, values that confirm that the complex is high-spin. Single crystals of the nonsolvated form shatter at low temperatures whereas single crystals of the solvated form can be cooled to 110 K with no loss of crystallinity and remain fully high spin at this temperature, Crystallographic information: nonsolvated form is triclinic, P (1) over bar, a = 8,8062(2) Angstrom, b = 10.3549(2) Angstrom, c = 11.3549(2) Angstrom, a = 104.0768(10), beta = 110.2473(10)degrees, gamma = 92.6385(11)degrees, Z = 1; solvated form is monoclinic P2(1)/c, a 10.3214(5) Angstrom, b = 12.7753(7) Angstrom, c = 20.1995(11) Angstrom, alpha = 90degrees, beta = 97.5380(10)degrees, gamma = 90degrees, Z = 2. [less ▲]

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See detailL'etude clinique du mois. La MRC/BHF Heart Protection Study.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(9), 613-6

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily ... [more ▼]

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily or matching placebo. In addition to being randomized to compare simvastatin vs placebo, all patients were also randomized to compare antioxidant vitamin supplementation (vitamin E 600 mg/day, vitamin C 250 mg/day and betacarotene 20 mg/day) vs placebo in a "2 x 2 factorial" design. Duration of the study was 5 years. All-cause mortality was significantly reduced among patients allocated to simvastatin (-12.3%) due to a highly significant (-18%) reduction in the coronary death rate, a marginally significant reduction in other vascular deaths and a non-significant reduction in non-vascular deaths. There were highly significant reductions (of about one-quarter) in the first event rate for non-fatal myocardial infarction and coronary death (combined), for non-fatal and fatal stroke and for coronary or non-coronary revascularization. The beneficial effect of simvastatin was seen in all sub-categories which were studied and, particularly: women vs men; patients aged > 70 years vs those aged < 70 years; patients with LDL cholesterol < vs > 116 mg/dl, or total cholesterol < vs > 193 mg/dl. The treatment was well tolerated and the annual risk of myopathy was 0.01%. All comparisons between antioxidant vitamin supplementation and placebo failed to reveal any difference in favour or against the supplementation which was otherwise well tolerated. These important results and their implications will be briefly discussed. [less ▲]

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See detailCompte rendu de l’ouvrage de Gianluca Mori : Bayle philosophe
Donneau, Olivier ULg

in Hieros : Bulletin Annuel de la Société Belgo-luxembourgeoise d'Histoire des Religions (2002), 6

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See detailDifferential pathomechanisms of epidermal necrolytic blistering diseases.
Paquet, Philippe ULg; Pierard, Gérald ULg

in International Journal of Molecular Medicine (2002), 10(6), 695-9

Staphylococcal scalded skin syndrome (SSSS) results from the effect of exfoliative-toxins produced by staphylococcal strains. The disease affects predominantly children, and is rare in adults. We report ... [more ▼]

Staphylococcal scalded skin syndrome (SSSS) results from the effect of exfoliative-toxins produced by staphylococcal strains. The disease affects predominantly children, and is rare in adults. We report two cases of the adult type of SSSS. Corticotherapy, chronic alcohol abuse and epilepsy-related immune changes might have been predisposing factors in these patients. The immunopathological characteristics of the inflammatory cell infiltrate in adults SSSS have not been thoroughly explored so far in the literature. Biopsies from 2 patients with bullous SSSS skin were studied by means of immunochemistry using a panel of 10 antibodies directed to FXIIIa, CD15, CD31, CD45R0, CD50, CD54, CD62E, CD95, CD106, and L1-protein, respectively. Cutaneous biopsies from related blistering diseases were compared. They included drug-induced toxic epidermal necrolysis (TEN), bullous impetigo and superficial pemphigus. A dense cell infiltrate composed of granulocytes (CD15+), macrophages (L1 protein+) and memory T cells (CD45R0+) and a strong expression of ICAM-3 (CD50) were present in the epidermis. CD95+ keratinocytes were lining the intraepidermal blisters. Type I dermal dendrocytes (Factor XIIIa+) were numerous and plump in the dermis. Bullous impetigo exhibited the same pattern of inflammatory cells, but with a lower density in type I dermal dendrocytes. TEN differed from SSSS by both the absence of CD15+ granulocytes and a stronger expression of the pro-apoptotic CD95 antigen in the epidermis. In superficial pemphigus, CD95 antigen was not expressed, and CD15+ granulocytes, CD45R0+ lymphocytes and L1 protein+ monocytes were much less numerous. It is concluded that the specific binding of SSSS-induced exotoxins to the desmosomes alters the keratinocyte metabolism leading to an inflammatory reaction followed by focal apoptosis. Our findings are in line with the concept that SSSS exotoxins might be superantigens. A common pathomechanism leading to epidermal destruction is likely operative in SSSS and bullous impetigo. The inflammatory cell composition in TEN and superficial pemphigus markedly differs from that in SSSS. [less ▲]

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See detailHsp27 in the nervous system: expression in pathophysiology and in the aging brain.
Krueger-Naug, A. M. R.; Plumier, Jean-Christophe ULg; Hopkins, D. A. et al

in Progress in Molecular and Subcellular Biology (2002), 28

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See detailRenouvellement des pédagogies musicales. Analyse et développement des innovations dans les cours d'instruments semi-collectifs
Giot, Bernadette ULg; Grifnée, Catherine

in Site du Ministère de la Communauté française de Belgique (2002)

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See detailReplicon typing of the F18 fimbriae encoding plasmids of enterotoxigenic and verotoxigenic Escherichia coli strains from porcine postweaning diarrhoea and oedema disease
Fekete, PZs; Gérardin, J.; Jacquemin, E. et al

in Veterinary Microbiology (2002), 85

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See detailMyopathies atypiques chez les chevaux au pré: une série de cas en Belgique
Delguste, Catherine ULg; Cassart, Dominique ULg; Baise, Etienne ULg et al

in Annales de Médecine Vétérinaire (2002), 146(4, AUG-SEP), 235-247

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liege between November 2000 and April 2001 ... [more ▼]

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liege between November 2000 and April 2001, with a clinical history suggesting atypical myoglobinuria. Lesions were similar to those previously described. All horses were at rest and grazing when they developed clinical signs. Three times, the syndrome killed several horses grazing together. Horses were generally found recumbent, nearly or totally unable to stand up. They were presenting tachycardia, polypnoea, myoglobinuria and died rapidly. When performed, blood analysis revealed severe muscular enzymatic activity rises. Histopathology revealed pulmonary congestion and oedema, and squeletal muscular fibers degeneration, mostly in respiratory and postural muscles. These observations are in accordance with cases of atypical myoglobinuria previously described in UK and Germany. The aetiology of this pathology is still unknown, despite of research attempts. [less ▲]

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See detailMR1905401,, Khan, A. R. and Elkamel, A., Mathematical model for heat transfer mechanism for particulate System, Appl. Math. Comput.
Rochus, Pierre ULg

in Applied Mathematics and Computation (2002), 129(2-3), 295--316

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See detailEcology of Salmonella in slaughter pigs digestive tract and study of the contamination of carcasses
Boudry, Christelle ULg; Korsak Koulagenko, Nicolas ULg; Jacob, Benoit et al

in Annales de Médecine Vétérinaire (2002), 146(6, DEC-JAN), 353-360

This article presents a study on the Salmonella asymptomatic carriage of finishing pigs and its consequences on the contamination of carcasses. Twenty finishing pigs were followed to determine the faecal ... [more ▼]

This article presents a study on the Salmonella asymptomatic carriage of finishing pigs and its consequences on the contamination of carcasses. Twenty finishing pigs were followed to determine the faecal shedding of Salmonella. No sample was positive but at the slaughterhouse, the analysis of tonsils and certain parts of the digestive tract (mesenterial lymph nodes, ileum and large intestine content) revealed that 70% of the pigs were positive. The strains isolated from the faecal samples of the large intestine and from tonsils were identical, which might indicate that there has been an oral contamination from pig to pig due to the shedding of Salmonella or a carriage of different strains in different organs. The mesenterial lymph nodes (40 % positive) were contaminated by strains which were different from those from the faecal samples and tonsils. Salmonella strains were only found on the swabs of one carcass. A complementary assay has shown the negative role played by the scalding step. This latter may contaminate the oral and rectal cavities of slaughtered animals. This entire study reveals the difficulty to predict the contamination risk at the slaughterhouse from the analysis of finishing pigs faecal samples. Therefore, a better knowledge of the carriage and the shedding of Salmonella during the finishing period and during the slaughter is necessary to minimise meat contamination. [less ▲]

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See detailLes lithométéores au Niger: mise au point.
Ozer, Pierre ULg

in Würzburger Geographische Arbeiten (2002), (97), 7-32

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See detailLa libre circulation des personnes dans l'Union européenne (1er janvier - 31 décembre 2001)
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2002), 10(3), 65

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See detailDelays in claiming social security benefits
Jousten, Alain ULg; Diamond, P.; Coile, C. et al

in Journal of Public Economics (2002), 84

This paper focuses on Social Security benefit claiming behavior, a take-up decision that has been ignored in the previous literature. Using financial calculations and simulations based on an expected ... [more ▼]

This paper focuses on Social Security benefit claiming behavior, a take-up decision that has been ignored in the previous literature. Using financial calculations and simulations based on an expected utility maximization model, we show that delaying benefit claim for a period of time after retirement is optimal in a wide variety of cases and that gains from delay may be significant.We find that approximately 10% of men retiring before their 62nd birthday delay claiming for at least 1 year after eligibility. We estimate hazard and probit models using data from the New Beneficiary Data System to test four cross-sectional predictions. While the data suggest that too few men delay, we find that the pattern of delays by early retirees is generally consistent with the hypotheses generated by our theoretical model. [less ▲]

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See detailDetermination of affinity, stoichiometry and sequence selectivity of minor groove binder complexes with double-stranded oligodeoxynucleotides by electrospray ionization mass spectrometry
Rosu, Frédéric ULg; Gabelica, Valérie ULg; Houssier, Claude ULg et al

in Nucleic Acids Research (2002), 30(16), 82

Electrospray mass spectrometry was evaluated regarding the reliability of the determination of the stoichiometries and equilibrium association constants from single spectra. Complexes between minor groove ... [more ▼]

Electrospray mass spectrometry was evaluated regarding the reliability of the determination of the stoichiometries and equilibrium association constants from single spectra. Complexes between minor groove binders (Hoechst 33258, Hoechst 33342, DAPI, netropsin and berenil) and 12mer oligonucleotide duplexes with a central sequence (A/T)(4) flanked by G/C base pairs were chosen as model systems. To validate the electrospray ionization mass spectrometry (ESI-MS) method, comparisons were made with circular dichroism and fluorescence spectroscopy measurements. ESI-MS allowed the detection of minor (2 drug + DNA) species for Hoechst 33258, Hoechst 33342, DAPI and berenil with duplex d(GGGG(A/T)(4)GGGG). d(CCCC(A/T)(4)CCCC), which were undetectable with the other techniques. Assuming that the duplexes and the complexes have the same electrospray response factors, the equilbrium association constants of the 1:1 and 2:1 complexes were determined by ESI-MS, and the values show a good quantitative agreement with fluorescence determined constants for Hoechst 33258 and Hoechst 33342. It is also shown that ESI-MS can quickly give reliable information on the A/T sequence selectivity of a drug: the signal of a complex is directly related to the affinity of the drug for that particular duplex. The potential of ESI-MS as a qualitative and quantitative affinity screening method is emphasized. [less ▲]

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See detailL’authenticité iconographique des portails occidentaux de la cathédrale de Strasbourg
Van den Bossche, Benoît ULg

in Bulletin de la Cathédrale de Strasbourg (2002), 15

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See detailPéritexte auctorial ou éditorial ? Réflexions théoriques et suggestions pratiques
Vanhaegendoren, Koen ULg

in Annales de l’Université de Craiova, Série de littérature roumaine et comparée (2002), 24(1-2), 184-192

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See detailDes pratiques aux performances : la littératie chez les jeunes de 15 ans
Lafontaine, Dominique ULg

in Lettre de la DFLM (La) (2002), 30

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See detailIncreased fecundity of malathion-specific resistant beetles in absence of insecticide pressure
Arnaud, Ludovic; Brostaux, Yves ULg; Assie, Lazare Komenan et al

in Heredity (2002), 89(6), 425-429

Despite that resistance frequency is assumed to decline when selective pressure is relaxed, the stability of resistance frequency has been observed in some insects in the absence of insecticide. In the ... [more ▼]

Despite that resistance frequency is assumed to decline when selective pressure is relaxed, the stability of resistance frequency has been observed in some insects in the absence of insecticide. In the red flour beetle, Tribolium castaneum, the first case of malathion-resistance was reported in the early 1960s. The malathion-specific resistant phenotype has now almost completely replaced the susceptible one in red flour beetle populations. In the present study, several life-history traits that could influence the fitness of the insects were compared between insecticide-susceptible and malathion-specific resistant populations of the red flour beetle. On average, egg fertility and egg-to-adult development time did not differ between susceptible and resistant populations. However, the fecundity of resistant females was greater than that of susceptible ones. Generally, differences in development time between insecticide resistant and susceptible populations are considered as having more effect on fitness than do differences in fecundity. However, the observed increased female fecundity may participate, in combination with the previously observed increased male reproductive success, to the development and the stability of malathion-specific resistance in T. castaneum. [less ▲]

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See detailLa traducción, otra de las plenitudes de Borges
Willson, Patricia ULg

in Variaciones Borges (2002), (14), 103-112

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See detailÉtude dendrométrique d’Acacia auriculiformis A. Cunn. ex Benth. en mélange sur vertisol au Bénin
Fonton, N. H.; Glele Kakai, R.; Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(1), 29-37

Acacia auriculiformis is a fast growing species planted on vertisols in Benin. An inventory of 11 mixed stands of Acacia, which are 7 to 9 years old, has been realized to estimate growth parameters of the ... [more ▼]

Acacia auriculiformis is a fast growing species planted on vertisols in Benin. An inventory of 11 mixed stands of Acacia, which are 7 to 9 years old, has been realized to estimate growth parameters of the stands. The present study shows that, for the dendrometrical parameters, there is no difference between species associations at a 0.05 significance level. Nevertheless, the largest values of quadratic mean diameter of the stems foot are observed in the species associations including Leucaena leucocephala. Moreover, the branch volume decreases with the increasing of the number of stems per tree. The most appropriate volume function for Acacia auriculiformis is the one that takes into account the diameter of the stems foot and the total height. Otherwise, the species associations do not influence the profile of Acacia trees, which is constant within the associations. The predicted conversion and cutting coefficients show that the stacked wood volume represents about 144 % of the real stand volume. [less ▲]

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See detailAre time-based and event-based prospective memory affected by normal aging in the same way ?
Bastin, Christine ULg; Meulemans, Thierry ULg

in Current Psychology Letters: Behavious, Brain and Cognition (2002), 7

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See detailNonmyeloablative stem cell transplantation with CD8-depleted or CD34-selected peripheral blood stem cells.
Baron, Frédéric ULg; Baudoux, Etienne ULg; Frere, Pascale ULg et al

in Journal of Hematotherapy & Stem Cell Research (2002), 11(2), 301-14

To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed ... [more ▼]

To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed by CD8-depleted preemptive donor lymphocyte infusion (DLI) given in incremental doses on days 40 and 80. Fourteen patients with high-risk malignancies and an HLA-identical sibling (n = 8) or alternative donor (n = 6) but ineligible for a conventional transplant were included. Nonmyeloablative conditioning regimen consisted in 2 Gy total body irradiation (TBI) alone, 2 Gy TBI and fludarabine (previously untreated patients) or cyclophosphamide and fludarabine (patients who had previously received > or =12 Gy TBI). Patients 1-4 (controls) received unmanipulated peripheral blood stem cells (PBSC) and DLI and patients 5-14 CD8-depleted or CD34-selected PBSC followed by CD8-depleted DLI. Post-transplant immunosuppression was carried out with cyclosporine A (CsA) and mycophenolate mofetil (MMF). Initial engraftment was seen in all patients, but 1 patient (7%) later rejected her graft. The actuarial 180-day incidence of grades II-IV acute GVHD was 75% for patients 1-4 versus 0% for patients 5-14 (p = 0.0019). Five of 14 patients were in complete remission (CR) 180 days after the transplant and 6/14 had partial responses. The 1-year survival rate was 69%, and nonrelapse and relapse mortality rates were 16 and 18%, respectively. We conclude that CD8-depleted or CD34-selected NMSCT followed by CD8-depleted DLI is feasible and considerably decreases the incidence of acute GVHD while preserving engraftment and apparently also the graft-versus-leukemia (GVL) effect. Further studies are needed to confirm this encouraging preliminary report. [less ▲]

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See detailCombining problem structure and basis reduction to solve a class of hard integer programs
Louveaux, Quentin ULg; Wolsey, Laurence A.

in Mathematics of Operations Research (2002), 27(3), 470-484

We consider a hard integer programming problem that is difficult for the standard branch-and-bound approach even for small instances. A reformulation based on lattice basis reduction is known to be more ... [more ▼]

We consider a hard integer programming problem that is difficult for the standard branch-and-bound approach even for small instances. A reformulation based on lattice basis reduction is known to be more effective. However the step to compute the reduced basis, even if it is found in polynomial time, becomes a bottleneck for small to medium instances. By using the structure of the problem, we show that we can decompose the problem and obtain the basis by taking the kronecker product of two smaller bases easier to compute. Furthermore, if the two small bases are reduced, the kronecker product is also reduced up to a reordering of the vectors. Computational results show the gain from such an approach. [less ▲]

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See detailOn Sally Ledger and Roger Luckhurst’s The Fin de Siècle: A Reader in Cultural History c.1880-1900
Steyaert, Kris ULg

in Journal of Gender Studies (2002), 11(2), 192-193

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See detailThe efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favour of a medico-surgical aproach
Donnez, Jacques; Chantraine, Frédéric ULg; Nisolle, Michelle ULg

in Human Reproduction Update (2002), 8(1), 89-94

This review discusses the efficacy of a combined, medical (GnRH agonist) and surgical, therapy in endometriosis- associated infertility. Because of the limited information currently available on the ... [more ▼]

This review discusses the efficacy of a combined, medical (GnRH agonist) and surgical, therapy in endometriosis- associated infertility. Because of the limited information currently available on the activity of lesions in minimal and mild endometriosis, any absolute statement is inappropriate at this time, although some arguments exist in favour of treating endometriosis at laparoscopy. In moderate and severe endometriosis, this review provides arguments in favour of a medico-surgical approach and discusses the possibility of combining medical and surgical therapy. [less ▲]

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See detailComment etablir le bilan de fin de traitement des patients atteints de lymphomes non-hodgkiniens (LNH) de malignite intermediaire ou elevee?
Warland, V.; Jerusalem, Guy ULg; Hustinx, Roland ULg et al

in Revue Médicale de Liège (2002), 57(12), 779-84

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to ... [more ▼]

Incomplete regression of a lymphomatous mass after chemotherapy and/or radiotherapy constitutes a major problem in the treatment of lymphoma. In patients with persisting tumor, it could be reasonable to use salvage therapy and possibly hematopoietic stem cell transplantation at the time of minimal disease rather than at the time of clinically overt relapse. The authors reviewed the most appropriate imaging techniques for the assessment of response to treatment. The limitations of CT and MRI for predicting the nature of residual masses are well known. 67Ga scintigraphy has become a standard procedure for the posttreatment evaluation of patients with lymphoma, but it appears that 18F-FDG PET may be a more effective method. Personal experience in the field of PET scan is reported. Although PET should be considered the noninvasive imaging modality of choice, a histological confirmation of residual disease is always necessary before starting salvage therapy. 18F-fluorodeoxyglucose is not a tumor specific radiotracer. [less ▲]

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See detailDérogations au zonage en droit wallon de l'urbanisme
Pâques, Michel ULg

in Actualité législative en droit immobilier (2002)

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See detailN-(3-Phenoxy-4-pyridinio)methanesulfonamidate
Michaux, C.; Charlier, C.; Julémont, F. et al

in Acta Crystallographica (2002)

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See detailOptimization of recombinant human erythropoietin therapy after allogeneic hematopoietic stem cell transplantation.
Baron, Frédéric ULg; Sautois, Brieuc ULg; Baudoux, Etienne ULg et al

in Experimental hematology (2002), 30(6), 546-54

OBJECTIVE: Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with prolonged anemia caused by defective erythropoietin (Epo) production. We enrolled 34 recipients of an allogeneic ... [more ▼]

OBJECTIVE: Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with prolonged anemia caused by defective erythropoietin (Epo) production. We enrolled 34 recipients of an allogeneic HSCT in three consecutive trials to determine the optimal utilization of recombinant human erythropoietin (rhEpo) therapy in this setting. MATERIALS AND METHODS: In the first trial (n = 7), rhEpo 1400 U/kg/week was given from day 1 until a hemoglobin (Hb) level of 10 g/dL was achieved, for a maximum of 60 days. In the second trial, rhEpo 500 U/kg/week was given to achieve Hb levels of 13 to 14 g/dL in 13 anemic patients with fatigue 56 to 1440 days after transplant. In the third trial, rhEpo was scheduled to start on day 35 in 14 patients at a dose of 500 U/kg/week with the aim of achieving Hb levels of 13 to 14 g/dL. RESULTS: In trial 1, erythroid recovery to 1% reticulocytes and red blood cell transfusion independence were faster, but the number of transfusions was not reduced compared to 10 controls. Responses were brisk in trial 2, with transfusion independence achieved after a median of 1 week in 12 of 13 patients, and 2-g Hb increments or Hb values of 11, 12, and 13 g/dL after 6, 7, 10, and 10 weeks, respectively. Transfusions were significantly reduced in the first month of rhEpo therapy. In trial 3, transfusion independence was obtained after a median of 1 week in 13 of 14 patients, and 2-g Hb increments or Hb values of 11, 12, and 13 g/dL after 3, 4, 6, and 8 weeks, respectively. Transfusions rates were considerably reduced compared to the previous month in the same patients or compared to controls undergoing peripheral blood or marrow transplant without rhEpo. CONCLUSIONS: Anemia after allogeneic HSCT is exquisitely sensitive to rhEpo. The benefit is minimal when it is given early post-transplant, as used in all trials to date. However, the rate of major response is greater than 90% when rhEpo is started after day 35. These data provide the basis on which to conduct a prospective, randomized, placebo-controlled trial of rhEpo therapy after allogeneic HSCT. [less ▲]

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See detailA biomimetic synthesis of coelenterazine analogs
Devillers, Ingrid; Arrault, Axelle; Olive, Gilles ULg et al

in Tetrahedron Letters (2002), 43(17), 3161-3164

N-(Trifluoroacetyl)dehydrodipeptides 2–3 were coupled to aminomethylene dimethylacetal derivatives 4–5. The resulting pseudo-tripeptides 6 were stepwise deprotected (carbonyl function (7) then amine ... [more ▼]

N-(Trifluoroacetyl)dehydrodipeptides 2–3 were coupled to aminomethylene dimethylacetal derivatives 4–5. The resulting pseudo-tripeptides 6 were stepwise deprotected (carbonyl function (7) then amine function) and in situ cyclized into imidazolopyrazines 1. [less ▲]

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See detailRevue bibliographique: les methodes chimiques d'identification et de classification des champignons.
Verscheure, M.; Lognay, Georges ULg; Marlier, M.

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(3), 131-142

For few years, advancements of molecular methods and analytical techniques enabled scientists to realise a classification of microorganisms based on biochemical characteristics. This classification ... [more ▼]

For few years, advancements of molecular methods and analytical techniques enabled scientists to realise a classification of microorganisms based on biochemical characteristics. This classification, called chemotaxonomy, includes molecular methods and chemical methods which provide additional data and lead to a better identification and/or classification. [less ▲]

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See detailVers de nouveaux modes de communication sur les risques
Brunet, Sébastien ULg; hupet, Pierre

in Sécurité au travail (2002), n°100(1), 566-573

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See detailA qui appartient le ragondin ?
Roussel, Laurence; Mougenot, Catherine ULg

in Espaces et Sociétés (Paris, France) (2002), (110-111), 225-247

La lutte contre le ragondin, espèce importée d'Amérique du Sud en Europe, aujourd'hui classée parmi les espèces invasives, a été inscrite simultanément dans deux législations différentes. Dans le ... [more ▼]

La lutte contre le ragondin, espèce importée d'Amérique du Sud en Europe, aujourd'hui classée parmi les espèces invasives, a été inscrite simultanément dans deux législations différentes. Dans le mondeagricole, c'est une action qui s'inspire de la guerre contre les ravageurs des cultures. Elle s'organise collectivement à l'aide d'un poison, la bromadiolone. Dans le monde de la chasse, elle est principalement du domaine des piégeurs. Solitaires, ceux-ci pourchassent le ragondin en tant qu'espèce nuisible. Cette division est héritée du Moyen Âge, de ses usages de l'espace et des droits qui leur étaient associés (droit de destruction pour les agriculteurs). Actuellement, l'espace rural peut être vu comme une mosaïque, òu ces deux principaux types de lutte coexistent, alors que certains milieux restent libres de toute intervention. Mais ces actions sont aussi l'objet de critiques qui mettent en cause l'utilisation de la bromadiolone et certaines formes de piégeage. Et aujourd'hui, on observe que les modalités de lutte contre le ragondin se combinent aux nouveaux usages de l'espace. [less ▲]

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See detailAspartic proteinase members secreted by the ruminant placenta: Specificity of three radioimmunoassay systems for the measurement of pregnancy-associated glycoproteins
Perenyi, Z. S.; Szenci, O.; Drion, Pierre ULg et al

in Reproduction in Domestic Animals (2002), 37(6), 324-329

Pregnancy-associated glycoproteins (PAGs) isolated from the placenta of various ruminant species are enzymatically inactive members of the aspartic proteinase family. The measurement of these proteins in ... [more ▼]

Pregnancy-associated glycoproteins (PAGs) isolated from the placenta of various ruminant species are enzymatically inactive members of the aspartic proteinase family. The measurement of these proteins in the maternal blood can be a good indicator of the presence of a live embryo. As certain aspartic proteinases are present in biological fluids in physiological and pathological conditions at various concentrations, it was necessary to determine the specificity of three radioimmunoassay (RIA) systems currently used for the detection of PAG molecules. Commercially available members of the aspartic proteinase family like pepsinogen, pepsin, chymosin, rennet, cathepsin D and renin were tested in a wide concentration range (10 ng/ml - 1 mg/ml). Pepsinogen cross-reacted in RIA 1, RIA 2 and RIA 3 over 1 mg/ml, 50 microg/ml and 500 microg/ml concentrations, respectively. In the presence of pepsin, cross-reaction was observed in RIA 1, RIA 2 and RIA 3 over 1 mg/ml, 500 microg/ml and 1 mg/ml concentrations, respectively. Chymosin and rennet could cross-react in RIA 2 and RIA 3, while renin and cathepsin D did not decrease the binding of the tracer to antisera more, than that of the minimal detection limit. As the plasma/serum concentrations of the examined aspartic proteinases reported in the literature were outside the concentration range where cross-reaction was observed, it can be concluded that these RIA systems were specific for the detection of PAGs in biological fluids. [less ▲]

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See detailUtilisation du bootstrap pour les problèmes statistiques liés à l'estimation des paramètres.
Palm, Rodolphe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(3),

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See detailUtilisation de la ropivacaine par voie peridurale pour l'analgesie postoperatoire.
Senard, Marc ULg; Joris, Jean ULg

in Annales Françaises d'Anesthésie et de Réanimation (2002), 21(9), 713-24

OBJECTIVES: To describe pharmacology and toxicology of ropivacaine. To assess the clinical efficacy of ropivacaine when used for postoperative epidural analgesia and to provide recommendations for ... [more ▼]

OBJECTIVES: To describe pharmacology and toxicology of ropivacaine. To assess the clinical efficacy of ropivacaine when used for postoperative epidural analgesia and to provide recommendations for clinical practice. DATA SOURCES: Search in the Medline data base of original articles in French and English published since 1995, using the following key words: ropivacaine, postoperative analgesia, epidural, caudal block. STUDY SELECTION: Prospective randomised studies in adults and children were selected. Letters to editors and editorials were excluded. DATA EXTRACTION: Articles have been analyzed: to determine the dose of ropivacaine required for postoperative epidural analgesia, to assess the benefits of combination of epidural ropivacaine and additives (opioids or other), to compare epidural ropivacaine and bupivacaine and to assess the use of ropivacaine via caudal route for paediatric postoperative analgesia. DATA SYNTHESIS: 20 mg h-1 of ropivacaine is required to provide effective analgesia. This dose produces a motor block in a significant number of patients. Combination with an opioid allows for a reduction in ropivacaine requirement and subsequently in the incidence of motor blockade. In adults, equipotency ratio of ropivacaine and bupivacaine varies between 1.5/1 and 1/1 depending upon the concentration used. At equipotent doses, early postoperative mobilisation is facilitated with ropivacaine. In case of paediatric caudal analgesia, this ratio is close to 1. CONCLUSIONS: Epidural ropivacaine combined with opioid provide good postoperative pain relief. Reduction in the incidence of motor blockade and safe toxicological profile make this local anaesthetic a suitable alternative of bupivacaine for postoperative epidural analgesia. [less ▲]

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See detailQuelques tournures péjoratives dans le débat philosophiques en sanskrit
Verpoorten, Jean-Marie ULg

in Indologica Taurinensia (2002)

Répertoire de 48 termes méprisants ou insultants utilisés par des philosophes antagonistes pour qualifier leurs adversaires et leurs doctrines. On notera d’ailleurs qu’il existe également des auteurs qui ... [more ▼]

Répertoire de 48 termes méprisants ou insultants utilisés par des philosophes antagonistes pour qualifier leurs adversaires et leurs doctrines. On notera d’ailleurs qu’il existe également des auteurs qui écrivent leurs œuvres en igorant toute polémique et toute attaque personnelle. Ainsi Maņḍanamiśra (vers 700.). D’autres, au nombre de 26 ci-après, se laissent aller à la critique personnelle (sans d’ailleurs citer l’opposant par son nom) et à l’invective. L’article énumère les mots ainsi utilisés dans l’ordre alphabétique du sanskrit et y joint un bref commentaire. Voici quelques exemples. Le bouddhiste Dignāga décrit ses adversaires comme de « mauvais logiciens » (kutarka) imbus de leurs vues erronées (abhimāna). Tout en utilisant le terme de « votre honneur » (āyuṣmant , tatrabhavant) , on traitera l’opposant de « fou » (unmatta, jaḍa, mūrkha, pramatta, manda, mūḍha), de « gosse » (bāla), d’ « animal » (paśu). A noter l’expression devānāṃpriya « chéri des dieux » synonyme de « fou », qui équivaut mutatis mutandis à « imbécile heureux ». On peut ajouter des expressions d’indignation et de mépris comme « ah, la grande folie ! propos totalement stupide, propos d’aveugle, divagation, énormité ». [less ▲]

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See detailLe complexe de l'intrus, ou l'effet de l'écart d'âge sur les membres d'une fratrie
Haxhe, Stéphanie ULg

in Dialogue : Recherches Cliniques et Sociologiques sur le Couple et la Famille (2002), 157(3), 107-116

This article deals with a study realized amongst siblings whose gaps in age were different. It attempts to bring out the whole importance of this variable to the development of the siblings, considered in ... [more ▼]

This article deals with a study realized amongst siblings whose gaps in age were different. It attempts to bring out the whole importance of this variable to the development of the siblings, considered in its « normality ». It notably points out how the intensity of the differences between full siblings of the same sex and with a small gap in age can be understood (indeed, sisters and brothers who are close in age and of the same sex, particularly amongst siblings of two, often appear to be very different and complementary). But this article also shows how the mark of the intrusion is different according to the age of the elder during this intrusion and how the impact of this variable (which is yet so little studied) seems to be significant in the individuals’development, on the narcissistic level as much as in the affects management. [less ▲]

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See detailAnalyse de l'impact physiologique et economique de l'elagage des arbres d'alignement en port libre.
Toussaint, André ULg; Kervyn de Meerendre, V.; Delcroix, B. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(2), 99-107

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See detailThree-dimensional organization of active rRNA genes within the nucleolus.
Cheutin, Thierry; O'Donohue, Marie*-Francoise; Beorchia, Adrien et al

in Journal of Cell Science (2002), 115(Pt 16), 3297-307

In this work, we have localized transcribing rRNA genes at the ultrastructural level and described their three-dimensional organization within the nucleolus by electron tomography. Isolated nucleoli ... [more ▼]

In this work, we have localized transcribing rRNA genes at the ultrastructural level and described their three-dimensional organization within the nucleolus by electron tomography. Isolated nucleoli, which exhibit a reduced transcriptional rate, were used to determine the sites of initial BrUTP incorporation (i.e. rRNA synthesis by the transcriptional machinery). Using pulse-chase experiments with BrUTP and an elongation inhibitor, cordycepin, it was possible to precisely localize the initial sites of BrUTP incorporation. Our data show that BrUTP incorporation initially takes place in the fibrillar centers and that elongating rRNAs rapidly enter the surrounding dense fibrillar component. Furthermore, we investigated the spatial arrangement of RNA polymerase I molecules within the whole volume of the fibrillar centers. Electron tomography was performed on thick sections of cells that had been labeled with anti-RNA polymerase I antibodies prior to embedding. Detailed tomographic analyses revealed that RNA polymerase I molecules are mainly localized within discrete clusters. In each of them, RNA polymerase I molecules were grouped as several coils, 60 nm in diameter. Overall, these findings have allowed us to propose a model for the three-dimensional organization of transcribing rDNA genes within the nucleolus. [less ▲]

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See detailConfirmation des effets délétères rénaux des AINS anti COX2 illustrée par trois cas cliniques
Piront, P.; Krzesinski, Jean-Marie ULg

in Acta Clinica Belgica (2002), 57(1), 35

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See detailMechanism of action of a lipophilic salicylic acid derivative on normal skin.
Leveque, J.-L.; Corcuff, P.; Rougier, A. et al

in European Journal of Dermatology (2002), 12(4), -

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See detailInfluence of the metal electronic properties on the sum-frequency generation spectra of dodecanethiol self-assembled monolayers on Pt (111), Ag (111) and Au (111) single crystals
Dreesen, Laurent ULg; Humbert, Christophe; Celebi, M. et al

in Applied Physics B : Lasers & Optics (2002), 74

Infrared-visible sum-frequency generation (SFG) spectroscopy is performed at different visible wavelengths between 450 and 650 nm in order to investigate the interaction between metallic substrates (Pt ... [more ▼]

Infrared-visible sum-frequency generation (SFG) spectroscopy is performed at different visible wavelengths between 450 and 650 nm in order to investigate the interaction between metallic substrates (Pt, Ag and Au) and 1-dodecanethiol self-assembled monolayers. We show that such measurements provide a means to study the electronic properties of metals as well as the interference phenomena between the SFG signals from the adsorbate and the substrate. The common features of the three interfaces are the vibration modes of the terminal methyl groups. However, these resonances appear as peaks for Pt (111) and as dips in the case of Ag (111). Their shape is not modified when the visible wavelength is tuned between 450 and 650 nm. Moreover, the metal sum-frequency generation contribution is slightly modified in that spectral range. For Au (111) samples, the sum-frequency generation spectrum drastically evolves with the visible wavelength: the peak resonant sum-frequency generation signal at 450 nm becomes rather dip-shaped at 650 nm. The non-linear response of gold is also enhanced when the wavelength associated with the sum-frequency process is close to 480 nm. These results are interpreted on the basis of the metal electronic properties that are responsible for the non-resonant contribution to the SFG signal. [less ▲]

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See detailThe genetic absence epilepsy rat from Strasbourg (GAERS), a rat model of absence epilepsy: Computer modeling and differential gene expression
Lakaye, Bernard ULg; Thomas, E.; Minet, Arlette ULg et al

in Epilepsia (2002), 43(Suppl. 5), 123-129

Purpose: We present results obtained by computer modeling of the thalamic network and differential gene expression analysis in a rat strain with absence epilepsy, the genetic absence epilepsy rat from ... [more ▼]

Purpose: We present results obtained by computer modeling of the thalamic network and differential gene expression analysis in a rat strain with absence epilepsy, the genetic absence epilepsy rat from Strasbourg (GAERS). Methods: (a) Computer modeling used equations from the Hodgking-Huxley model with a circuit of 13 reticular thalamic (nRt) and 39 thalamocortical (TC) neurons; (b) gene-expression analysis using differential mRNA display (DD), in situ hybridization, Northern blotting, and competitive reverse transcriptase-polymerase chain reaction (RT-PCR). Results: (a) Computer modeling showed an increased network synchrony in the thalamic circuit as the value of conductance of low-voltage activated calcium channel (LVACC) is increased. (b) Using differential mRNA display, a 40% upregulation of the H-ferritin mRNA in the hippocampus was demonstrated. Looking for some candidate genes of the VACC family, no difference was found in the alpha1G mRNA expression between GAERS and control animals, whereas a decreased expression of the alpha1E subunit was observed in the cerebellum and the brainstem of the GAERS. This phenomenon was not observed in young animals when the epileptic phenotype is not expressed. Conclusions: The use of computer modeling appeared to be an efficient way to evaluate the impacts of electrophysiologic findings in vivo from single cells on an entire circuit. No clear single gene defect was revealed so far in GAERS. More information could arise from linkage analysis. However, some brain structures like hippocampus or cerebellum classically not known to be involved in the production of absence spike-and-wave discharges could in fact participate in the development of this phenotype. [less ▲]

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See detailEEMCO guidance for the measurement of skin microcirculation.
Berardesca, E.; Lévêque, Jean Luc; Masson, P. et al

in Skin Pharmacology & Applied Skin Physiology (2002), 15

The blood supply to the skin is provided by a network of arterioles, capillaries and venules organized into a superficial and a deep plexus. The assessment of skin microcirculation is of valuable interest ... [more ▼]

The blood supply to the skin is provided by a network of arterioles, capillaries and venules organized into a superficial and a deep plexus. The assessment of skin microcirculation is of valuable interest in cosmetology in the quantification of the sun protection factor, skin irritation and efficacy of antiredness treatments. Skin microcirculation can be measured by means of different techniques, based mainly on the quantification of optical and thermal properties of the skin which are modified by the amount of blood perfusion. Relevant and reproducible data can be obtained only through the understanding of the biophysical background of the technique(s) utilized. Standardization of measuring conditions and procedures is particularly required for blood flow assessment. In this paper, the advantages and disadvantages of the main techniques in use are discussed, and optimization of measurements for laser Doppler techniques is described. [less ▲]

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See detailDétermination automatique de la taille du pas de temps pour les schémas implicites en dynamique non-linéaire
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Mécanique & Industries (2002), 3(1), 63-77

Pour les problèmes caractérisés par de fortes non-linéarités, ainsi que des phénomènes d'impacts et de contacts, une stratégie d'intégration à pas de temps variables est particulièrement intéressante. Ces ... [more ▼]

Pour les problèmes caractérisés par de fortes non-linéarités, ainsi que des phénomènes d'impacts et de contacts, une stratégie d'intégration à pas de temps variables est particulièrement intéressante. Ces phénomènes sont par exemple rencontrés lors de l'étude dynamique d'une interaction aube-carter d'un moteur d'avion, le cas le plus critique étant la perte de l'aube. Une stratégie d'intégration implicite à pas de temps constant donne rarement satisfaction du fait qu'il est pratiquement impossible de déterminer une durée de pas qui ne conduise pas à la divergence ou à un coût de calcul prohibitif. Une gestion automatique du pas de temps, qui tient compte de l'histoire récente des accélérations dans le corps considéré, est proposée. En fait, l'algorithme est basé sur la mesure de l'erreur d'intégration des équations d'équilibre. Cela permet d'intégrer correctement les phénomènes transitoires avec un pas de temps très long (en régime) ou très petit (lors de la perte d'aube), en garantissant une bonne précision en un temps de calcul raisonnable. De plus, un algorithme qui décide automatiquement de recalculer ou non, la matrice hessienne est proposé. Cet algorithme permet d'éviter un nombre important de remises à jour de cette matrice, ce qui permet de réduire le coût de calcul tout en assurant la convergence. Enfin, un critère de divergence des itérations est proposé. Afin d'illustrer l'efficacité des algorithmes développés, des simulations numériques sont présentées. Il s'agit aussi bien de problèmes académiques que de problèmes industriels (contacts aubes carter). [less ▲]

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See detailGiovani autori crescono malgrado tutto
Delhalle, Nancy ULg

in Hystrio, trimestriale di teatro e spettacolo (2002), (2),

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See detailAdaptation to multiday ozone exposure is associated with a sustained increase of bronchoalveolar uric acid.
Kirschvink, Nathalie; Fievez, Laurence ULg; Bureau, Fabrice ULg et al

in Free Radical Research (2002), 36(1), 23-32

The phenomenon of ozone tolerance is described, but the underlying mechanisms remain unknown. We tested whether adaptation to multiday ozone exposure was related to an upregulated pulmonary antioxidant ... [more ▼]

The phenomenon of ozone tolerance is described, but the underlying mechanisms remain unknown. We tested whether adaptation to multiday ozone exposure was related to an upregulated pulmonary antioxidant defence. Six calves were exposed to 0.75 ppm ozone, 12 h day(-1) for seven consecutive days. Pulmonary function tests and bronchoalveolar lavage (BAL) were performed before, after the first (D1), third (D3) and seventh (D7) exposure. Differential cell count, total proteins, 8-epi-PGF2alpha, glutathione and uric acid were determined in BAL. Dynamic lung compliance and arterial oxygen tension were significantly decreased and lung oedema impaired pulmonary function on D1. By repeating ozone exposures, progressive functional adaptation occurred. Ozone induced a significant increase of BAL neutrophil percentage on D1. On D3 and D7, neutrophil percentage was progressively decreased, but remained significantly elevated. BAL total proteins were significantly increased on D1 and decreased progressively until D7. 8-Epi-PGF2alpha was significantly increased on D1 and was returned to baseline on D3 and D7, whilst glutathione significantly increased on D3 and returned to baseline on D7. Uric acid was increased ten-fold on D1. On D3, uric acid was increased six-fold and was persistently elevated at D7. This study suggests that ozone adaptation of functional and inflammatory variables is accompanied with sustained BAL uric acid elevation. [less ▲]

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See detailExiste-t-il des limites juridiques à la privatisation des entreprises publiques?
Thirion, Nicolas ULg

in Revue Internationale de Droit Economique (2002)

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See detailImpact des méthodes d'application sur l'efficacité d'un traitement à base de Pichia anomala souche K contre les maladies de post-récolte des pommes
Jijakli, Haissam ULg; Dickburt, Catherine; Lepoivre, Philippe ULg et al

in VIII journées scientifiquesBiotechnologies végétales: valorisation pour une agriculture durable (2002)

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See detailSaberes e instrumentos para ler os territórios próximos e distantes
Merenne-Schoumaker, Bernadette ULg

in Educação Geográfica (2002), (15), 43-54

Cet article rend compte de l'expérience de la Fédération des Professeurs de Géographie de la Communauté française de Belgique pour aider à la mise en place d'une pédagogie par compétences et plus ... [more ▼]

Cet article rend compte de l'expérience de la Fédération des Professeurs de Géographie de la Communauté française de Belgique pour aider à la mise en place d'une pédagogie par compétences et plus spécifiquement du guide conceptuel que nous avons rédigé pour apprendre aux élèves à lire les territoires du monde [less ▲]

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See detailInfluence of Sieve Trays on the Mass Transfer of Single Drops
Henschke, Martin; Pfennig, Andreas ULg

in AIChE Journal (2002), 48(2), 227-234

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See detailMemory kernels and effective Hamiltonians from time dependent methods. II. Vibrational predissociation
Brems, Vincent; Desouter, Michèle ULg

in Journal of Chemical Physics (2002), 116

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See detailComment j'explore ... Le risque d'un patient d'evoluer vers un diabete de type 2.
Scheen, André ULg; Paquot, Nicolas ULg; Jandrain, Bernard ULg

in Revue Médicale de Liège (2002), 57(2), 113-5

Both the prevalence and the incidence of type 2 diabetes are increasing rapidly. Effective prevention measures, including lifestyle or drug prescription, have been recently reported. It is thus important ... [more ▼]

Both the prevalence and the incidence of type 2 diabetes are increasing rapidly. Effective prevention measures, including lifestyle or drug prescription, have been recently reported. It is thus important to detect at risk individuals in order to provide appropriate diet and exercise recommendations or even pharmacological treatment. We summarize the most useful indices based on anamnesis, clinical examination and biological assays that can help to detect subjects at high risk of progression towards type 2 diabetes. [less ▲]

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See detailAnalysis of a Permanent Magnet Generator With Dual Formulations Using Periodicity Conditions and Moving Band
Luz, M V Ferreira da; Dular, Patrick ULg; Sadowski, N. et al

in IEEE Transactions on Magnetics (2002), 38(2), 961--964

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See detailLes transports en commun ne sont plus très sûrs : un autre regard sur la sécurité
Jacquemain, Marc ULg

in Politique : Revue de Débats (2002), 27

L'article utilise conjointement des exemples vécus et une enquête pour montrer, à partir du cas des transports en commun, à quel point la notion d'insécurité peut se construire socialement : un même ... [more ▼]

L'article utilise conjointement des exemples vécus et une enquête pour montrer, à partir du cas des transports en commun, à quel point la notion d'insécurité peut se construire socialement : un même contexte apparaîtra ainsi comme sécurisant ou insécurisant en fonction des interprétations et réactions des acteurs. L'article conclut en se demandant si une réponse ostentatoire mais symbolique à la possibilité d'événements insécurisants ne produit finalement pas plus d'insécurité encore. Ce qui demanderait un "changement de logiciel" dans certaines politiques publiques destinées à lutter contre l'insécurité. [less ▲]

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See detailSelf-esteem, social adjustment and suicidality in affective disorders
Daskalopoulou, E; Dikeos, D; Papadimitriou, G et al

in European Psychiatry (2002), 17

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See detailDoes sulfide detoxication occur in the gills of the hydrothermal vent shrimp, Rimicaris exoculata?
Compère, Philippe ULg; Martinez, Anne-Sophie; Charmantier-Daures, Mireille et al

in Comptes Rendus Biologies (2002), 325

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