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See detailEnhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway
Turlej, Renata K; Fievez, Laurence ULg; Sandersen, Charlotte ULg et al

in Thorax (2001), 56(9), 696-702

As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we ... [more ▼]

As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we sought to determine whether asthma is also associated with a GM-CSF dependent increase in lung granulocyte survival. Moreover, because GM-CSF mediates its effects through activation of signal transducer and activator of transcription 5 (STAT5), we also investigated the potential role of STAT5 in allergic inflammation. METHODS: Blood granulocytes were recovered from six healthy and six heaves affected horses, a model of asthma. Lung granulocytes were obtained by bronchoalveolar lavage (BAL) from the same horses. Granulocytes were cultured in the presence or absence of anti-GM-CSF receptor antibodies for different times and apoptosis was determined using the Annexin-V/propidium iodide detection method. Nuclear protein extracts from cultured granulocytes were analysed for STAT5 binding activity by electrophoretic mobility shift assay. RESULTS: BAL fluid granulocytes from heaves affected horses demonstrated a significant delay in apoptosis compared with blood granulocytes from the same horses and blood and BAL fluid granulocytes from healthy horses. Conversely, the rate of apoptosis in blood granulocytes from healthy and heaves affected horses was comparable. The enhanced survival of BAL fluid granulocytes from affected horses was suppressed in the presence of antibodies directed against GM-CSF receptors. Increased levels of active STAT5 were found in BAL fluid granulocytes from heaves affected horses and were markedly reduced after treatment with anti-GM-CSF receptor antibodies. CONCLUSIONS: These data indicate that granulocyte survival is enhanced in the lung of heaves affected horses and suggest a role for a GM-CSF activated STAT5 pathway in delaying apoptosis of lung granulocytes in this model of asthma. [less ▲]

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See detailArchéométrie et orfèvrerie mosane : émaux du Musée Curtius sous l’œil du cyclotron
George, Philippe ULg; Weber, Georges ULg; Martinot Lucien et al

in Bulletin de l'Institut Historique Liégeois (2001)

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See detailSize dependence of interior-to-edge ratios: size predominates shape.
Bogaert, Jan ULg

in Acta Biotheoretica (2001), 49(2), 121-123

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See detailAn Early Devonian flora, including Cooksonia from the Paraná Basin (Brazil)
Gerrienne, Philippe ULg; Bergamaschi, S.; Pereira, E. et al

in Review of Palaeobotany and Palynology (2001), 116

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See detailLe Mésolithique du Bassin pannonien et la formation du Rubané
Otte, Marcel ULg; Noiret, Pierre ULg

in Anthropologie (L') (2001), 105(3, JUL-SEP), 409-419

The LBK appears as the result of acculturation of local Mesolithic Populations, beginning in the Pannonian Basin following a trans-Balkan colonisation. Economy, architecture and ceramic proceed from an ... [more ▼]

The LBK appears as the result of acculturation of local Mesolithic Populations, beginning in the Pannonian Basin following a trans-Balkan colonisation. Economy, architecture and ceramic proceed from an adaptation to local means, which explains the chronological disjunction between acculturation and geographic expansion. The whole is placed within a context already Indo-European, since the Late Palaeolithic. (C) 2001 Editions scientifiques et medicales Elsevier SAS. [less ▲]

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See detailDissemination of Catabolic Plasmids among Desiccation-Tolerant Bacteria in Soil Microcosms
Weekers, Frederic; Rodriguez, Christian; Jacques, Philippe ULg et al

in Applied Biochemistry and Biotechnology (2001), 91-93(Spring), 219-32

The dissemination of catabolic plasmids was compared to bioaugmentation by strain inoculation in microcosm experiments. When Rhodococcus erythropolis strain T902, bearing a plasmid with trichloroethene ... [more ▼]

The dissemination of catabolic plasmids was compared to bioaugmentation by strain inoculation in microcosm experiments. When Rhodococcus erythropolis strain T902, bearing a plasmid with trichloroethene and isopropylbenzene degradation pathways, was used as the inoculum, no transconjugant was isolated but the strain remained in the soil. This plasmid had a narrow host range. Pseudomonas putida strain C8S3 was used as the inoculum in a second approach. It bore a broad host range conjugative plasmid harboring a natural transposon, RP4::Tn4371, responsible for biphenyl and 4-chlorobiphenyl degradation pathways. The inoculating population slowly decreased from its original level (10(6) colony-forming units [CFU]/g of dry soil) to approx 3 x 10(2) CFU/g of dry soil after 3 wk. Transconjugant populations degrading biphenyl appeared in constant humidity soil (up to 2 x 10(3) CFU/g) and desiccating soil (up to 10(4) CFU/g). The feasibility of plasmid dissemination as a bioaugmentation technique was demonstrated in desiccating soils. The ecologic significance of desiccation in bioaugmentation was demonstrated: it upset the microbial ecology and the development of transconjugants. [less ▲]

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See detailSerum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria.
Verhoef, H.; West, C. E.; Ndeto, P. et al

in American Journal of Clinical Nutrition (2001), 74(6), 767-75

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum ... [more ▼]

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum transferrin receptor concentrations are not or are only marginally influenced by the inflammatory response to infection. OBJECTIVE: We assessed iron status and examined the relation between serum transferrin receptor concentrations and malaria in children aged 2-36 mo who were asymptomatic for malaria. DESIGN: This was a community-based cluster survey (n = 318). RESULTS: Prevalences of malaria, anemia (hemoglobin concentration <110 g/L), iron deficiency (serum ferritin concentration <12 microg/L), and iron deficiency anemia were 18%, 69%, 53%, and 46%, respectively. Malaria was associated with lower mean hemoglobin concentrations (92.7 compared with 104.1 g/L; P = 0.0001) and higher geometric mean serum concentrations of transferrin receptor (11.4 compared with 7.8 mg/L; P = 0.005), ferritin (21.6 compared with 11.9 microg/L; P = 0.05), and C-reactive protein (12.5 compared with 6.8 mg/L; P = 0.004). There was no evidence for an association between serum concentrations of C-reactive protein and transferrin receptor. Children with malaria had higher serum transferrin receptor concentrations than expected for the degree of anemia, even after adjustment for inflammation indicated by serum C-reactive protein concentration quartiles (P = 0.02). CONCLUSIONS: Our findings are consistent with the notion that malaria-induced hemolysis is accompanied by increased erythropoiesis. Serum transferrin receptor concentration is not useful for detecting iron deficiency in individuals with malaria. Individuals with high concentrations of serum C-reactive protein or similar acute phase reactants should be excluded from analysis if serum ferritin concentrations <12 microg/L are to be used to measure iron deficiency in malaria-endemic areas. [less ▲]

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See detailLa recherche de l'environnement pertinent, contribution à une géographie du sensible
Schmitz, Serge ULg

in Espace Géographique (L') (2001), 30(4), 321-332

Which factors heighten sensitivity to environmental changes? The answer to this question is of interest to everyone who acts on the environment. However, methods and concepts still need to be explored ... [more ▼]

Which factors heighten sensitivity to environmental changes? The answer to this question is of interest to everyone who acts on the environment. However, methods and concepts still need to be explored before a geography of sensibility could respond to this deman. This paper presens the methodological contributions and results of an exploratory study of the sensibilities of 65 residents of a Belgian rural municipality. Factors related to the environmental change, to the individual and to the relantionship between the individual and place are analysed. [less ▲]

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See detailA propos du remplage de la verrière d'Esther.
Morard, Thomas ULg

in Arte Cristiana (2001), 89(802), 23-30

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See detailFlow interruption effects on intake rate and rill erosion in two soils
Sirjacobs, Damien ULg; Shainberg, Itzhak; Rapp, Ido et al

in Soil Science Society of America Journal (2001), 65

Efficiency of surface irrigation is often low because of poor infiltration uniformity, resulting from relatively long periods of infiltration at the upstream end and short periods of infiltration at the ... [more ▼]

Efficiency of surface irrigation is often low because of poor infiltration uniformity, resulting from relatively long periods of infiltration at the upstream end and short periods of infiltration at the downstream end of the field. Surge irrigation, the intermittent supply of water to furrows, generally reduces soil intake rate (IR) and improves moisture uniformity over the entire field. However, IR reduction varies from one irrigation scheme to another, depends on soil and water properties, and is difficult to predict. A laboratory study using miniflumes was designed to investigate the effect of interrupted flow on IR and soil loss from short rills. Two soils differing in their textures, a silt loam (Calcic Haploxeralf) derived from loess and a clay soil (Typic Haploxerert), were studied. Intake rate in the clay soil was greater than that in the silt loam. Therefore, different inflow rates were applied to the two soils to achieve similar runoff flow rates from the two soils. Cumulative infiltration decreased from 646 mL in continuous flow to 539 mL in interrupted flow for the silt loam and from 1142 to 1068 mL in the clay soil. Interrupted flow also reduced cumulative soil loss by 84% in the clay soil but had only a small effect on soil loss from the silt loam. However, when flow rate was increased from 80 to 320 mL min−1, interrupted flow reduced soil loss in the silt loam as much as in the clay soil. Consolidation of the soil surface and formation of cohesive forces between soil particles of the silt loam with unstable structure during flow interruption was suggested as the explanation for the effect of flow interruption on intake rate and soil detachment. These results need to be verified in field experiments. [less ▲]

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See detailThe organotypic culture of HPV-transformed keratinocytes: an effective in vitro model for the development of new immunotherapeutic approaches for mucosal (pre)neoplastic lesions.
Delvenne, Philippe ULg; Hubert, Pascale ULg; Jacobs, Nathalie ULg et al

in Vaccine (2001), 19(17-19), 2557-64

The purpose of this study is to develop a reliable in vitro human model to test new immunotherapeutic approaches for squamous cell carcinoma that develop on mucosal surfaces. The organotypic (raft ... [more ▼]

The purpose of this study is to develop a reliable in vitro human model to test new immunotherapeutic approaches for squamous cell carcinoma that develop on mucosal surfaces. The organotypic (raft) culture permits cells to proliferate and differentiate at an air-liquid interface on a dermal equivalent support. Normal keratinocytes stratify and fully differentiate in a manner similar to the normal squamous epithelial tissues, while human papillomavirus-immortalized and established squamous carcinoma cell lines exhibit dysplastic morphologies similar to (pre)neoplastic lesions seen in vivo. We have demonstrated the ability of these organotypic cultures to be manipulated by altering the epithelial stratification with cytokines (interferon-gamma and tumor necrosis factor-alpha) and by integrating activated lymphocytes or dendritic cells into the in vitro formed epithelial sheet. This model may provide a useful tool to investigate the factors contributing to the presence and function of immunocompetent cells within a neoplastic epithelium that develops on a mucosal surface. [less ▲]

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See detailApplication of the accelerated shelf life testing method (ASLT) to study the survival rates of freeze-dried Lactococcus starter cultures
Achour, M.; Mtimet, N.; Cornelius, C. et al

in Journal of Chemical Technology & Biotechnology (2001), 74

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See detailComparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.
Paulsen, M.; Takada, S.; Youngson, N. A. et al

in Genome Research (2001), 11(12), 2085-94

The Dlk1-Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have sequenced ... [more ▼]

The Dlk1-Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have sequenced this conserved region in the mouse and sheep and included the human sequence in a three species comparison. This analysis resulted in a precise conservation map and identification of highly conserved sequence elements, some of which we have shown previously to be differentially methylated in the mouse. Additionally, this analysis facilitated identification of a CpG-rich tandem repeat array located approximately 13-15 kb upstream of Gtl2. Furthermore, we have identified a third imprinted transcript that overlaps with the last Dlk1 exon in the mouse. This transcript lacks a conserved open reading frame and is probably generated by cleavage of extended Dlk1 transcripts. Because Dlk1 and Gtl2 share many of the imprinting properties of the well-characterized Igf2-H19 domain, it has been proposed that the two regions may be regulated in the same way. Comparative genomic examination of the two domains indicates that although there are similarities, other features are very different, including the location of conserved CTCF-binding sites, and the level of conservation at regulatory regions. [less ▲]

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See detailExpression, purification, crystallization and preliminary X-ray analysis of the native class C beta-lactamase from Enterobacter cloacae 908R and two mutants.
Wouters, J.; Charlier, Paulette ULg; Monnaie, D. et al

in Acta Crystallographica Section D-Biological Crystallography (2001), 57(Pt 1), 162-4

Crystals have been obtained of the Enterobacter cloacae 908R beta-lactamase and two point mutants by the vapour-diffusion method using similar conditions [pH 9.0, polyethylene glycol (M(r) = 6000) as ... [more ▼]

Crystals have been obtained of the Enterobacter cloacae 908R beta-lactamase and two point mutants by the vapour-diffusion method using similar conditions [pH 9.0, polyethylene glycol (M(r) = 6000) as precipitant]. The three crystal forms belong to the orthorhombic space group P2(1)2(1)2, with roughly the same unit-cell parameters; i.e. for the wild-type crystals a = 46.46, b = 82.96, c = 95.31 A. In the best cases, the crystals diffract to about 2.1 A resolution on a rotating-anode X-ray source at room temperature. Co-crystallization experiments of poor substrates with the wild-type protein and the active-site serine mutant (S64C) are planned and should lead to a better understanding of the catalytic mechanism of class C beta-lactamases. [less ▲]

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See detailNote de lecture - 385. Un vers de Cassius de Parme (CRF tg. fr. inc. 4 Ribbeck)
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (2001), 60(2, APR-JUN), 464-465

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See detailThe interior-to-edge breakpoint distance as a guideline for nature conservation policy.
Bogaert, Jan ULg; Salvador-Van Eysenrode, D; Impens, I

in Environmental Management (2001), 27(4), 493-500

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See detailIrradiation du petit bassin et fonction ano-rectale.
Gervaz, P; COUCKE, Philippe ULg; Gillet, M

in Gastroentérologie Clinique et Biologique (2001), 25

Le traitement adjuvant des cancers du rectum a pour buts de stériliser la maladie résiduelle infra-clinique et d’améliorer le contrôle local. Depuis plus de 20 ans, des milliers de malades ont été inclus ... [more ▼]

Le traitement adjuvant des cancers du rectum a pour buts de stériliser la maladie résiduelle infra-clinique et d’améliorer le contrôle local. Depuis plus de 20 ans, des milliers de malades ont été inclus dans des études randomisées, visant d’abord à mettre en évidence un gain de survie et une réduction des récidives loco-régionales, en relation avec la radiothérapie pré- ou postopératoire, combinée ou non à la chimiothérapie. Les conséquences en termes de qualité de vie de ces traitements ont pourtant été peu étudiées, et la tolérance fonctionnelle du néo-rectum et de l’appareil sphinctérien à la radiothérapie restent mal connues [1]. Les difficultés liées à l’étude des effets de l’irradiation sur les tissus normaux, ainsi que la variabilité inter-individuelle de la réponse à la radiothérapie, s’ajoutent et rendent le sujet plus complexe encore. Les radiothérapeutes adaptent leur technique afin de réduire autant que possible la dose administrée aux tissus normaux avoisinant la tumeur. Dans le cas de l’irradiation du petit bassin, c’est l’intestin grêle qui a longtemps été considéré comme la structure à risque de complications, alors que l’atteinte du sphincter anal était rarement mentionnée [2]. Malgré les répercussions importantes de la dysfonction ano-rectale sur la qualité de vie des malades, l’atteinte du sphincter anal par la radiothérapie est restée un aspect négligé du traitement adjuvant des cancers du petit bassin [3]. Cet article a pour but, à travers une revue de la littérature, de mettre en évidence les effets qualitatifs et quantitatifs de la radiothérapie sur la fonction du sphincter anal, ainsi que de proposer une modification de la technique actuelle d’irradiation des cancers du bas rectum. [less ▲]

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See detailUn nouveau projet archéologique de l'Université de Lyon 2.
Morard, Thomas ULg; Wavelet, David

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2001), 113(1), 477-481

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See detailL'Ecole du dos
Crielaard, Jean-Michel ULg; Henrotin, Yves ULg; DEFAWEUX, Michel ULg et al

in Bulletin d'Education du Patient à sa Maladie (2001), 20

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See detailGeological application of digital imaging
Pirard, Eric ULg; Jongmans, Denis; Marsh, Stuart

in Computers & Geosciences (2001), 27(9), 1015-1017

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See detailEpisphalosomic Syndrome : A Mca Syndrome Ressembling Fanconi Anemia, with Increased Baseline Level of Chromosome Breaks but No Hypersensivity to Clastogens
Verloes, Alain ULg; JAMAR, Mauricette ULg; Dideberg, Vinciane ULg et al

in Annales de Génétique (2001), 44(2, Apr-Jun), 59-62

We describe a child with facial dysmorphism (trigonocephaly, epicanthus, upturned nose, small ears), thumb hypoplasia, micropenis, jejunal atresia and moderate mental retardation with dysphasia ... [more ▼]

We describe a child with facial dysmorphism (trigonocephaly, epicanthus, upturned nose, small ears), thumb hypoplasia, micropenis, jejunal atresia and moderate mental retardation with dysphasia. Cytogenetic workup revealed high spontaneous level of chromosomal aberrations (without specific pattern and no quadriradial figures) and borderline to absent hypersensitivity to mitomycin C, making a diagnosis of Fanconi anemia unlikely. The child described here shares similarities with a small number of previous reports. We suggest to refer to this entity as episphalosomic syndrome. Episphalosomic syndrome shows some clinical overlap with Fanconi anemia, but lacks its cytogenetic hallmark. The hematological complications of Fanconi anemia have not been reported in this entity. [less ▲]

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See detailPetrology and geochemistry of rapakivi-type granites from the crystalline basement of NE Poland
Baginski, Boguslaw; Duchesne, Jean-Clair ULg; Vander Auwera, Jacqueline ULg et al

in Geological Quarterly (2001), 45(1), 33-52

The collection of 80 rock samples coming from drillcores of 8 localities from the Mazury Complex (Polish part of the crystalline East European Craton) and representing different rock types from ... [more ▼]

The collection of 80 rock samples coming from drillcores of 8 localities from the Mazury Complex (Polish part of the crystalline East European Craton) and representing different rock types from monzodiorites to leucogranites, were studied for major, trace and REE elements by XRF and ICP-MS methods. The range in composition of investigating rocks varies from 46% to 76% SiO2 contents. All of them show similar REE distributions, what suggests that they are genetically linked. They also plot along a major trend with many similarities to the jotunitic liquid line of descent (LLD) defined in AMCG rocks from Rogaland (Norway). Each group of rocks has however its own characteristics considering specific elements, such as REE, Sr or Zr. [less ▲]

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See detailGilbert Boss : la fin de l'ordre économique
Jacquemain, Marc ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2001), 81-92-93

L'ouvrage propose une transformation radicale des valeurs pour quitter l'ordre marchand. S'il partage des intuitions avec la vision marxiste, il s'en écarte aussi radicalement par son élitisme parfois ... [more ▼]

L'ouvrage propose une transformation radicale des valeurs pour quitter l'ordre marchand. S'il partage des intuitions avec la vision marxiste, il s'en écarte aussi radicalement par son élitisme parfois presque anti-démocratique. On pourrait parler à propos de Gilbert Boss, de socialisme conservateur aristocratique. Une utopie décapante mais pas forcément séduisante. [less ▲]

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See detailRheology of compatibilized immiscible viscoelastic polymer blends
Iza, Mustapha; Bousmina, Mosto; Jérôme, Robert ULg

in Rheologica Acta (2001), 40(1), 10-22

Rheological behavior of a PS/PE model viscoelastic immiscible blend compatibilized by two types of inter facial modifiers was investigated. Dynamic, steady shear, and transient experiments were performed ... [more ▼]

Rheological behavior of a PS/PE model viscoelastic immiscible blend compatibilized by two types of inter facial modifiers was investigated. Dynamic, steady shear, and transient experiments were performed to probe the effect of the interfacial modification on the rheological behavior of the blend. While the effect was relatively small in dynamic and steady shear experiments, significant signature of the presence of the copolymer was observed in transient experiments after start up of shear flow. The magnitude of the departure from Doi-Otha theory (worked out for non-compatibilized blends) was evaluated. [less ▲]

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See detailLe XIXe siècle
Duchesne, Jean-Patrick ULg

in Art&fact (2001), 20

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See detailPreparation of poly(D,L-lactide) nanoparticles assisted by amphiphilic poly(methyl methacrylate-co-methacrylic acid) copolymers
Gautier, Sandrine; Grudzielski, Nathalie; Goffinet, Gerhard ULg et al

in Journal of Biomaterials Science. Polymer Edition (2001), 12(4), 429-450

When co-precipitated with amphiphilic copolymers from DMSO, poly(D,L-lactide) (PLA) can be readily converted into stable sub-200 nm nanoparticles by addition of an aqueous phase, free of any polymeric ... [more ▼]

When co-precipitated with amphiphilic copolymers from DMSO, poly(D,L-lactide) (PLA) can be readily converted into stable sub-200 nm nanoparticles by addition of an aqueous phase, free of any polymeric stabilizers such as poly(vinyl alcohol) or Poloxamer. In this work, the ability of random poly(methyl methacrylate-co-methacrylic acid) copolymers (PMMA-co-MA) to stabilize PLA nanoparticles was demonstrated, and the properties of PLA/PMMA-co-MA nanoparticles were investigated. When co-precipitated with PMMA-co-MA, PLA was totally converted into nanoparticles using a polymer concentration in DMSO (Cp) below 17.6 mg ml(-1), and a PMMA-co-MA proportion above a critical value depending on the content of MA repeating units (X). For instance, the lowest PMMA-co-MA proportion required was 0.9 mg mg(-1) PLA for X = 12%, and 0.5 mg mg(-1) PLA for X = 25% (for C(PLA) = 16 mg ml(-1) DMSO). The nanoparticle diameter was essentially independent of X, the proportion of PMMA-co-MA, and the PLA molecular weight, except for oligomers for which the nanoparticle diameter was smaller. It decreased when the organic phase was diluted (126 +/- 13 nm for Cp = 17.6 mg ml(-1), and 81 +/- 5 nm for C(P) = 5.6 mg ml(-1)). The time-dependence of the stability and the degradation of PLA/PMMA-co-MA nanoparticles was discussed. One of the main advantages of this technique is the ability to control surface properties and to bring functional groups to otherwise non-functionalized PLA nanoparticles. To illustrate this, a conjugate of PMMA-co-MA25 and biotin was synthesized, and used to prepare biotinylated nanoparticles that could be detected by fluorescence and transmission electron microscopy after infiltration into ligatured rat small intestine. [less ▲]

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See detailLe cas clinique du mois. Maladie de Von Hippel-Lindau.
Gaspar, Y.; de Leval, Jean ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2001), 56(2), 68-71

VHL disease is a rare genetical disease with a poor long-term prognosis. Clinical features include retineous angiomas, CNS hemangioblastomas, pheochromocytomas and renal cysts. Renal cysts are bilateral ... [more ▼]

VHL disease is a rare genetical disease with a poor long-term prognosis. Clinical features include retineous angiomas, CNS hemangioblastomas, pheochromocytomas and renal cysts. Renal cysts are bilateral and frequently lead to malignant transformation. Surgical treatment of renal cysts is preferably delayed until a minimum of 3 cm diameter has been reached. Treatment has to be as conservative as possible, knowing that uni- or bilateral nephrectomy often has to be carried out later. [less ▲]

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See detailPoly(e-caprolactone) layered silicate nanocomposites: effect of clay surface modifiers on the melt intercalation process
Pantoustier, Nadège; Alexandre, Michaël ULg; Degée, Philippe et al

in e-Polymers (2001), (9), 1-9

Nanocomposites based on biodegradable poly(e-caprolactone) (PCL) and layered silicates (montmorillonite) modified by various alkylammonium cations were prepared by melt intercalation. Depending on whether ... [more ▼]

Nanocomposites based on biodegradable poly(e-caprolactone) (PCL) and layered silicates (montmorillonite) modified by various alkylammonium cations were prepared by melt intercalation. Depending on whether the ammonium cations contain non-functional alkyl chains or chains terminated by carboxylic acid or hydroxyl functions, microcomposites or nanocomposites were recovered as shown by X-ray diffraction and transmission electron microscopy. Mechanical and thermal properties were examined by tensile testing and thermogravimetric analysis. The layered silicate PCL nanocomposites exhibited some improvement of the mechanical properties (higher Young's modulus) and increased thermal stability as well as enhanced flame retardant characteristics as result of a charring effect. This communication aims at reporting that the formation of PCL-based nanocomposites strictly depends on the nature of the ammonium cation and its functionality, but also on the selected synthetic route, i.e. melt intercalation vs. in situ intercalative polymerization. Typically, protonated w-aminododecanoic acid exchanged montmorillonite allowed to intercalate e-caprolactone monomer and yielded nanocomposites upon in situ polymerization, whereas they exclusively formed microcomposites when blended with preformed PCL chains. In other words, it is shown that the formation of polymer layered silicate nanocomposites is not straightforward and cannot be predicted since it strongly depends on parameters such as ammonium cation type and functionality together with the production procedure, i.e., melt intercalation, solvent evaporation or in situ polymerization [less ▲]

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See detailEffect of Ketoconazole 1% and 2% Shampoos on Severe Dandruff and Seborrhoeic Dermatitis: Clinical, Squamometric and Mycological Assessments
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg; Arrese, J. E. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 202(2), 171-6

Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was ... [more ▼]

Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was carried out to differentiate the effectiveness of KET 1% and 2% in severe dandruff and seborrhoeic dermatitis. A total of 66 patients with severe dandruff or seborrhoeic dermatitis were randomized to each of the two groups. A 2-week run-in phase was followed by a 4-week treatment phase, in turn followed by a 4-week follow-up. The efficacy of treatments was evaluated by combining squamometry X, Malassezia spp. counts and clinical assessments. After 2 and 4 weeks of treatment, KET 2% was significantly superior over KET 1% (p < 0.001) for decreasing both in flakiness and Malassezia density from baseline. The same trend was observed in the mean change from baseline in the overall dandruff severity score. Only 6 mild adverse events were reported. During follow-up KET 2% showed a trend to fewer relapses than KET 1%. KET 2% had superior efficacy compared to KET 1% in the treatment of severe dandruff and scalp seborrhoeic dermatitis. Biometrological evaluations were correlated with the clinical improvements and therefore useful to incorporate in future dandruff studies. [less ▲]

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See detailLa chirurgie du thymus normal, involué ou tumoral
Limet, Raymond ULg; Rogister, Bernard ULg

in Revue Médicale de Liège (2001), 55

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See detailHollow atoms : a theoretical challenge
Vaeck, N; Hansen, J E; Palmeri, P et al

in Physica Scripta (2001), T95

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See detailInfections virales humaines d'origine alimentaire
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Point Vétérinaire (2001), 218

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See detailEtude empirique des estimateurs des taux d'erreur en analyse discriminante
Piraux, François; Palm, Rodolphe ULg

in Revue de Statistique Appliquée (2001), XLIX(4), 71-85

Monte Carlo experiments are performed to compare ten parametric and six non parametric estimators of the three error rates (actual, expected and optimal error rate) in discriminant analysis. This ... [more ▼]

Monte Carlo experiments are performed to compare ten parametric and six non parametric estimators of the three error rates (actual, expected and optimal error rate) in discriminant analysis. This comparison is restricted to the context of two p-dimensional normal group conditional distributions with the same covariance matrix. The study shows that certain estimators are markedly superior and users should be warned against some estimators available in statistical softwares. [less ▲]

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See detailContinuité de l'information, discontinuités sociales: NTIC, nouvelles formes d'organisation et dialogue social
Schoenaers, Frédéric ULg; Zune, Marc

in Revue de Gestion des Ressources Humaines (2001), 42

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See detailLe fédéralisme budgétaire : mode d'emploi
Husson, Jean-François ULg

in Reflets et Perspectives de la Vie Economique (2001), XL(3), 176

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See detailTreatment of recurrent tendinitis by isokinetic eccentric exercises
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Foidart-Dessalle, Marguerite ULg et al

in Isokinetics & Exercise Science (2001), 9(2-3), 133-141

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities ... [more ▼]

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities, Isokinetic eccentric training was administered to 34 patients with chronic tendinitis (9 Achilles, 10 patellar and 15 epicondyllar) with a long duration of symptoms and failure of conventional treatment. Following training which consisted of 20 to 30 sessions of progressive increase of load and speed parameters, a significant reduction of pain indicated by the visual analog scale (average initial value > 6.5, final score less than or equal to 2.5). Seventy four percent of the patients were completely relieved or presented marked decrease in symptoms when returning to sport and occupational activities. and only 12% reported no change in their functional state. At the end of treatment. isokinetic assessment revealed no significant concentric or eccentric peak torque asymmetries between involved and non-involved sides. In comparison with pretreatment ultrasound observations which showed systematic hypoechoic lesions and thickness, 14/34 patients recovered homogeneous tendon structure and normalization of the diameter and 15 presented improvement in echostructure. Our treatment model proposing isokinetic eccentric exercises presents a very satisfactory short-term effect on three different localizations of chronic tendinitis. [less ▲]

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See detailThe Influence of Fetal and Postnatal Growth on Heart Rate Variability in Young Infants
Massin, M. M.; Withofs, Nadia ULg; Maeyns, K. et al

in Cardiology (2001), 95(2), 80-3

Heart rate variability (HRV), a measure of cardiac autonomic control, was analyzed in infants to assess the hypothesis that early undernutrition may induce autonomic dysfunction that could play a role in ... [more ▼]

Heart rate variability (HRV), a measure of cardiac autonomic control, was analyzed in infants to assess the hypothesis that early undernutrition may induce autonomic dysfunction that could play a role in the programming of later cardiovascular disease. HRV data were collected during a night session in 546 healthy infants at 5-12 weeks of adjusted age, and statistical associations with fetal and postnatal growth indices were established. A significant positive correlation between birth weight, the ratio of neonatal weight to head circumference and postnatal weight gain, and HRV indices mostly influenced by sympathetic activity was demonstrated in 11- and 12-week-old infants. A slight correlation (p > 0.05) was also found in younger infants. These data suggest the influence of fetal and postnatal growth on the programming of the autonomic nervous system beyond the neonatal period. This influence may be one of the important mechanisms that link impaired growth in fetal and infant life to high blood pressure and other cardiovascular disease during childhood and adulthood (the Barker hypothesis). [less ▲]

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See detailThymic Expression of Insulin-Related Genes in an Animal Model of Autoimmune Type 1 Diabetes
Kecha-Kamoun, Ouafae; Achour, Imane; Martens, Henri ULg et al

in Diabetes/Metabolism Research & Reviews (2001), 17(2, Mar-Apr), 146-52

BACKGROUND: Insulin and multiple other autoantigens have been implicated in the pathogenesis of autoimmune type 1 diabetes, but the origin of immunological self-reactivity specifically oriented against ... [more ▼]

BACKGROUND: Insulin and multiple other autoantigens have been implicated in the pathogenesis of autoimmune type 1 diabetes, but the origin of immunological self-reactivity specifically oriented against insulin-secreting islet beta-cells remains obscure. The primary objective of the present study was to investigate the hypothesis that a defect in thymic central T-cell self-tolerance of the insulin hormone family could contribute to the pathophysiology of type 1 diabetes. This hypothesis was investigated in a classic animal model of type 1 diabetes, the Bio-Breeding (BB) rat. METHODS: The expression of the mammalian insulin-related genes (Ins, Igf1 and Igf2) was analysed in the thymus of inbred Wistar Furth rats (WF), diabetes-resistant BB (BBDR) and diabetes-prone BB (BBDP) rats. RESULTS: RT-PCR analyses of total RNA from WF, BBDP and BBDR thymi revealed that Igf1 and Ins mRNAs are present in 15/15 thymi from 2-day-old, 5-day-old and 5-week-old WF, BBDR and BBDP rats. In contrast, a complete absence of Igf2 mRNA was observed in more than 80% of BBDP thymi. The absence of detectable Igf2 transcripts in the thymus of BBDP rats is tissue-specific, since Igf2 mRNAs were detected in all BBDP brains and livers examined. Using a specific immunoradiometric assay, the concentration of thymic IGF-2 protein was significantly lower in BBDP than in BBDR rats (p<0.01). CONCLUSIONS: The present study suggests an association between the emergence of autoimmune diabetes and a defect in Igf2 expression in the thymus of BBDP rats. This tissue-specific defect in gene expression could contribute both to the lymphopenia of these rats (by impaired T-cell development) and the absence of central T-cell self-tolerance of the insulin hormone family (by defective negative selection of self-reactive T-cells). [less ▲]

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See detailEstimation of shortening rate since late Pleistocene in the Aksu area on the southern flank of the Tianshan
Wang, X.; Jia, C. Z.; Hubert, Aurelia ULg et al

in Science in China. Series D : Earth Sciences (2001), 44

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See detailL'image du mois. Perte de l'arythmie sinusale respiratoire dans la neuropathie autonome diabetique.
Scheen, André ULg; Geronooz, I.; Philips, Jean-Christophe ULg et al

in Revue Médicale de Liège (2001), 56(10), 669-70

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See detailA simple tool to identify asian women at increased risk of osteoporosis.
Koh, L K; Sedrine, W B; Torralba, T P et al

in Osteoporosis International (2001), 12(8), 699-705

Patients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available ... [more ▼]

Patients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available in some communities, because of cost and lack of equipment. Simple questionnaires have been designed to help target high-risk women for BMD measurements, thereby avoiding the cost of measuring women at low risk. However, such tools have previously focused on evaluation of non-Asian women. We collected information about numerous risk factors from postmenopausal Asian women in eight countries in Asia using questionnaires, and evaluated the ability of these risk factors to identify women with osteoporosis as defined by femoral neck BMD T-scores < or =-2.5. Multiple variable regression analysis and item reduction yielded a final tool based on only age and body weight. This risk index had a sensitivity of 91% and specificity of 45%, with an area under the curve of 0.79. Previously published risk indices based on larger numbers of variables performed similarly well in this Asian population. Large differences in risk were identified using our index to create three categories: 61% of the high-risk women had osteoporosis, compared with only 15% and 3% of the intermediate- and low-risk women, respectively. The low-risk group represented 40% of all women, for whom BMD measurements are probably not needed unless important risk factors, such as prior nonviolent fracture or corticosteroid use, are present. An existing population-based sample of postmenopausal Japanese women was used to validate our index. In this sample of Japanese women the sensitivity was 98% and specificity was 29%; the low-risk category, for whom BMD is probably unnecessary, represented 25% of all women. We conclude that our index performed well for classifying the risk of osteoporosis among postmenopausal Asian women and applying it would result in more prudent use of BMD technology. [less ▲]

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See detailEpdémiosurveillance de l'encéphalopathie spongiforme bovine en Belgique : bilan de l'année 1999
Saegerman, Claude ULg; Dechamps, P.; Roels, S. et al

in Annales de Médecine Vétérinaire (2001), 145

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See detailPolyploid formation in cotton is not accompanied by rapid genomic changes
Liu, B.; Brubaker, Cl.; Mergeai, Guy ULg et al

in Genome (2001), 44(3), 321-330

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See detailL'etude clinique du mois. Toxicite de l'hyperglycemie en soins intensifs et effets benefiques d'une insulinotherapie optimisee.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(12), 859-61

A large Belgian, prospective, controlled study was performed in 1.548 critically ill patients (83% without history of diabetes) hospitalised in a surgical intensive care unit. On admission, patients were ... [more ▼]

A large Belgian, prospective, controlled study was performed in 1.548 critically ill patients (83% without history of diabetes) hospitalised in a surgical intensive care unit. On admission, patients were randomly assigned to receive intensive intravenous insulin therapy (maintenance of blood glucose at a level between 80 and 110 mg/dl) or conventional treatment (infusion of insulin only if the blood glucose level exceeded 215 mg/dl and maintenance of glucose at a level between 180 and 200 mg/dl). Intensive insulin therapy reduced morbidity and mortality by 40%. These remarkable results should influence further therapeutical attitudes in intensive care units and open new perspectives for the management of critically ill patients. [less ▲]

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See detailNew species of the lichen genus Menegazzia in New Guinea
James, Peter W.; Aptroot, André; Diederich, Paul et al

in Bibiotheca Lichenologica (2001), 78

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See detailUrethral sphincterotomy for delivery of a vesical calculus in the mare: a case report
Deleuze, Stefan ULg; Hanzen, Christian ULg

in Annales de Médecine Vétérinaire (2001), 145(6, Suppl. S), 373-376

A case of a cystic calculus in a mare and the pathophysiology of urolithiasis are described. In this case a 268 g calculus measuring 9 x 6 cm was removed after urethro-sphincterotomy was performed on the ... [more ▼]

A case of a cystic calculus in a mare and the pathophysiology of urolithiasis are described. In this case a 268 g calculus measuring 9 x 6 cm was removed after urethro-sphincterotomy was performed on the standing mare. [less ▲]

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See detailUn oracle médical de Sarpédon à Séleucie du Calycadnos
Nissen, Cécile ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2001), 14

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See detailAdditive and dominance genetic variance of fertility by method R and preconditioned conjugate gradient
Druet, Tom ULg; Solkner, J.; Groen, A. F. et al

in Journal of Dairy Science (2001), 84(4), 9871-98716

The objectives of this study were threefold: 1) estimation of additive and dominance genetic variances for fertility traits for Austrian Simmental and Brown Swiss dairy cattle; 2) use of method R and the ... [more ▼]

The objectives of this study were threefold: 1) estimation of additive and dominance genetic variances for fertility traits for Austrian Simmental and Brown Swiss dairy cattle; 2) use of method R and the preconditioned conjugate gradient compared to solving for method R by second-order Jacobi iteration; and 3) study of the impact of inclusion of parental subclass effects on solutions for other random effects. Dominance variances were modeled for the inseminated cow and ranged from 0.32 to 1.36% of total variance. These values were similar to values for additive effects, which were approximately 1% of total variance. Convergence was clearly improved with preconditioned conjugate gradient and number of extrapolations reduced. Variance for permanent environment under a model without dominance could be split into a new estimate of permanent environmental variance and parental subclass variance. Solutions for parental subclass dominance effects were approximately proportional to permanent environment effects, but highly dependent on the number of animals contributing dominance relationships, especially full-sibs and three-quarter-sibs. For animals with a lot of dominance information (full-sibs, three-quarter-sibs, cousins), permanent environment and parental subclass dominance effects were nearly independent. Changes in additive effects were negligible, probably because both variances for parental subclass dominance effects and additive genetic effects were very small compared with residual variance. [less ▲]

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See detailUnraveling Oligodendrocyte Origin and Function by Cell-Specific Transgenesis
Belachew, Shibeshih ULg; Yuan, Xiaoqing; Gallo, Vittorio

in Developmental Neuroscience (2001), 23(4-5), 287-98

Besides the role of mature oligodendrocytes in myelin synthesis during the development of the central nervous system (CNS), the oligodendrocyte lineage also encompasses the largest pool of postnatal ... [more ▼]

Besides the role of mature oligodendrocytes in myelin synthesis during the development of the central nervous system (CNS), the oligodendrocyte lineage also encompasses the largest pool of postnatal proliferating progenitors whose behavior in vivo remains broadly elusive in health and disease. We describe here transgenic models that allow us to track the functions and origins of such cells by using proteolipid protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene promoters to direct oligodendroglial expression of different reporters, in particular the green fluorescent protein (GFP). We emphasize that the CNP-GFP mouse, which targets the entire oligodendroglial lineage from embryonic life to adulthood, provides an outstanding tool to study the in vivo properties of oligodendrocyte progenitor cells in normal and damaged CNS. [less ▲]

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See detailBronchoconstrictive properties of inhaled 8-epi-Pgf2alpha in healthy and heaves-susceptible horses
Kirschvink, Nathalie; Bureau, Fabrice ULg; Art, Tatiana ULg et al

in Veterinary Research (2001), 32(5, Sep-Oct), 397-407

The 8-epi-PGF2α is a marker of oxidative stress which is increased in lungs of asthmatic humans and heaves-susceptible horses. 8-Epi-PGF2α has also been demonstrated to be an in vitro and in vivo ... [more ▼]

The 8-epi-PGF2α is a marker of oxidative stress which is increased in lungs of asthmatic humans and heaves-susceptible horses. 8-Epi-PGF2α has also been demonstrated to be an in vitro and in vivo bronchoconstrictor in humans and rodents. We hypothesised that inhaled 8-epi-PGF2α was a bronchoconstrictor in healthy and heaves-susceptible horses in clinical remission. The effect on ventilatory mechanics of nebulised 8-epi-PGF2α was compared to that of PGF2α and U46619, a thromboxane A2 agonist. Pulmonary resistance (RL) and dynamic compliance (Cdyn) were assessed in six healthy horses and in six heaves-susceptible horses in clinical remission before (baseline) and immediately after a single inhalation challenge of 1 mg 8-epi-PGF2α, PGF2α, or U46619 and placebo. RL and Cdyn were unchanged after inhalation of 8-epi-PGF2α in healthy horses. In heaves-susceptible horses, 8-epi-PGF2α induced a significant increase of RL and a significant decrease of Cdyn when compared to baseline values. Differences between RL and Cdyn values after 8-epi-PGF2α inhalation and those of placebo inhalation were not significant. Differences with healthy horses were not significant. PGF2α and U46619 induced a significant bronchoconstriction in healthy (RL and Cdyn, versus baseline) and heaves-susceptible horses (RL and Cdyn, versus baseline and placebo). The RL increase in heaves-susceptible horses after PGF2α inhalation was significantly higher than that in healthy horses. Our results suggest that 8-epi-PGF2α is not a bronchoconstrictor in healthy horses, and a bronchoconstrictor far less efficient than PGF2α and U46619 at the same dose in heaves-susceptible horses [less ▲]

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See detailLes maisons de justice: une révolution tranquille?
Dantinne, Michaël ULg; Simon, Julie

in Actualités du Droit (2001)

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See detailL'assurance de qualité et le médecin de famille.
Roland, Michel; Prevost, Marianne; Jamoulle, Marc ULg

in Archives of Public Health (2001), 59

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See detailMechanisms of unconsciousness during general anaesthesia
BONHOMME, Vincent ULg; Hans, Pol

in Current Anaesthesia and Critical Care (2001), (12), 109-113

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See detailSolar Photocatalytic Destruction of p-Nitrophenol: A Pedagogical Use of Lab Wastes
Herrera-Melián, J. A.; Doña-Rodríguez, J. M.; Tello Rendón, E. et al

in Journal of Chemical Education (2001), 78(6), 775-777

In this article we propose the destruction of p-nitrophenol wastes obtained in a previous lab experiment, to generate a new lab experiment. The recommended destruction technique is solar TiO2 ... [more ▼]

In this article we propose the destruction of p-nitrophenol wastes obtained in a previous lab experiment, to generate a new lab experiment. The recommended destruction technique is solar TiO2-photocatalysis. When the effects of TiO2 and sunlight are tested separately, a slight decrease of p-nitrophenol is observed; but when TiO2 and sunlight are employed together p-nitrophenol disappears in 1 or 2 h. These experiments do not require sophisticated equipment or special lab training for the students. Groups of students tested different experimental conditions, such as the effect of different light intensities and sources (800-W UV-lamp, sunlight on sunny days, and sunlight on a cloudy day) or the addition of H2O2. p-Nitrophenol is degraded under the three light sources but at different rates. The addition of H2O2 to the TiO2-plus-sunlight system enhances p-nitrophenol degradation kinetics when compared with the TiO2 plus sunlight and H2O2 plus sunlight combinations. [less ▲]

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See detailExpression of Cu/Zn and Mn superoxide dismutases during bovine embryo development: influence of in vitro culture.
Lequarré, Anne-Sophie ULg; Feugang, Jean-Magloire; Malhomme, Olivier et al

in Molecular Reproduction and Development (2001), 58(1), 45-53

Temporal pattern of expression of Cu/Zn and Mn superoxide dismutases (SODs) was investigated in bovine oocytes and embryos produced in vitro in two different culture conditions and in vivo after ... [more ▼]

Temporal pattern of expression of Cu/Zn and Mn superoxide dismutases (SODs) was investigated in bovine oocytes and embryos produced in vitro in two different culture conditions and in vivo after superovulation. SODs were examined at a transcriptional level in single oocytes and embryos by reverse transcriptase-polymerase chain reaction (RT-PCR) and, at a protein level, by Western blotting on pools of embryos. mRNA encoding Cu/Zn SOD were detected in in vitro bovine embryos throughout preattachment development as well as in in vivo derived morulae and blastocysts. Transcripts for Mn SOD gene were detected in most immature and in vitro matured oocytes as well as in some zygotes and 5- to 8-cell embryos while no transcript was found at the 9-to 16-cell stage in both culture conditions. In vitro embryonic expression of Mn SOD was detected earlier in the presence of serum. Half of the morulae showed the transcript if cultured with 5% serum while none without serum. At the blastocyst stage Mn SOD could be detected independently of culture conditions. For in vivo-derived embryos Mn SOD transcripts were detected both in morulae and blastocysts. Immunoblotting analyses revealed that Cu/Zn SOD and Mn SOD were also present at a protein level in in vitro-derived zygotes and blastocysts. Together these data demonstrate, for the first time, that Mn SOD is transcribed and that Cu/Zn and Mn SOD proteins are expressed in preimplantation bovine embryos. Finally, they suggest that Mn SOD transcription is altered by in vitro culture conditions. [less ▲]

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See detailLe projet préscolaire de l'IEA : Améliorer la connaissance pour accroître la qualité des expériences vécues par les enfants d'âge préscolaire
Hindryckx, Geneviève ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 65-69

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See detailRhabdomyolyse fatale sous cerivastatine.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(8), 592-4

Cerivastatin was recently withdrawn from the market after the report of more than 30 deaths in the United-States among patients receiving a combination of cerivastatin and gemfibrozil, a fibrate which is ... [more ▼]

Cerivastatin was recently withdrawn from the market after the report of more than 30 deaths in the United-States among patients receiving a combination of cerivastatin and gemfibrozil, a fibrate which is not anymore on the Belgian market. The cause of death was attributed to severe rhabdomyolysis. Cases were also reported among patients treated by cerivastatin only. Recommendations for better use of lipid-lowering drugs are given in order to optimize the benefit/risk ratio of such treatment. [less ▲]

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See detailInfluence of culture conditions on lipopeptide production by Bacillus subtilis
Akpa, E.; Jacques, Philippe ULg; Wathelet, Bernard ULg et al

in Applied Biochemistry and Biotechnology (2001), 91-3

Bacillus subtilis produces various families of lipopeptides with different homologous compounds. To produce "new molecules" with improved activities and to select strains that produced a reduced number of ... [more ▼]

Bacillus subtilis produces various families of lipopeptides with different homologous compounds. To produce "new molecules" with improved activities and to select strains that produced a reduced number of homologs or isomers, we studied the effects of different media on the nature of the synthesis of fatty; acid chains for each lipopeptide family. This study focused on two B. subtilis strains cultivated in flasks. Optimized medium for lipopeptide production and Landy medium modified by replacing glutamic acid with other alpha -amino acids were used. We found that the intensity of production of homologous compounds depends on the strain and the culture medium. Analysis of these lipopeptides by high-performance liquid chromatography showed that the strain R. subtilis NT02 yielded various homologous compounds when cultivated in Landy medium (L-Glu), but primarily one homologous product in hi,oh relative amounts when cultivated in the optimized medium. Mass spectrometric analysis and determination of the amino acid composition of this molecule enabled us to identify it as Bacillomycine L c15. [less ▲]

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See detailCardiomyopathie rythmique recidivante secondaire a une tachycardie ventriculaire idiopathique.
Henrard-Toppets, Vinciane ULg; Pierard, Luc ULg

in Archives des maladies du coeur et des vaisseaux (2001), 94(6), 617-21

Tachycardia-induced cardiomyopathy consists in severe ventricular dysfunction and heart failure secondary to incessant or prolonged supraventricular or less frequently ventricular tachycardia in the ... [more ▼]

Tachycardia-induced cardiomyopathy consists in severe ventricular dysfunction and heart failure secondary to incessant or prolonged supraventricular or less frequently ventricular tachycardia in the absence of any cardiac disease. We present here a case of recurrent severe cardiomyopathy secondary to idiopathic ventricular tachycardia. Complete sustained recovery in function was observed after successful radiofrequency ablation of the ventricular tachycardia focus. To the best of our knowledge, this is the first report of recurrent tachycardia-induced cardiomyopathy. The diagnosis, aetiology, physiopathology and mechanisms of tachycardia-induced cardiomyopathy are discussed. Several therapeutic implications are presented. [less ▲]

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See detailÀ Stavelot-Malmedy entre 1080 et 1130. Cinquante ans de vie monastique revisités
George, Philippe ULg

in Bulletin des Bibliophiles liégeois (2001)

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See detailDetermination of the scattering coefficient of random rough diffusing surfaces for room acoustics applications
Embrechts, Jean-Jacques ULg; Archambeau, Dominique; Stan, Guy-Bart

in Acta Acustica United with Acustica (2001), 87

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See detailA simple clinical tool to identify Asian women with osteoporosis
Lou, SQ; Koh, L; Yang, BY et al

in Journal of Rheumatology (2001), 28(S63), 26

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See detailInfluence of temperature during cardiopulmonary bypass on leukocyte activation, cytokine balance, and post-operative organ damage
Qing, M.; Vazquez-Jimenez, J. F.; Klosterhalfen, B. et al

in Shock (Augusta, Ga.) (2001), 15(5), 372-7

This study examined the hypothesis that core temperature (T(o)) during cardiopulmonary bypass (CPB) influences the perioperative systemic inflammatory response and post-operative organ damage. Twenty-four ... [more ▼]

This study examined the hypothesis that core temperature (T(o)) during cardiopulmonary bypass (CPB) influences the perioperative systemic inflammatory response and post-operative organ damage. Twenty-four pigs were assigned to a T(o) regimen during CPB: normothermia (T(o) 37 degrees C; n = 8), moderate hypothermia (T(o) 28 degrees C; n = 8), or deep hypothermia (T(o) 20 degrees C; n = 8). Perioperative leukocyte activation, endotoxin release, and production of tumor necrosis factor-alpha (TNFalpha) and interleukin-10 (IL10) were examined with regard to post-operative organ damage, which was scored at histological examination of tissue probes of heart, lungs, liver, kidney, and ileum, taken 6 h after CPB. Total blood leukocyte count and TNFalpha plasma levels during CPB were significantly lower and IL10 levels were significantly higher in the moderate hypothermic group than in both other groups. Elastase activity, leukotriene B4-, and endotoxin levels were not affected by T(o) regimen. Moderate hypothermia was associated with the lowest histological organ damage score and normothermia with the highest. In all animals organ damage score for heart, lungs, and kidneys correlated significantly with TNFalpha levels at the end of CPB. Our data demonstrate a clear relationship between TNFalpha production during cardiac operations and post-operative multiple-organ damage. Moderate hypothermia, by stimulating IL10 synthesis and suppressing TNFalpha production during CPB, might provide organ protection. [less ▲]

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See detailL'etude clinique du mois. Prevention du diabete de type 2 chez le sujet avec exces ponderal et diminution de la tolerance au glucose: efficacite des mesures hygieno-dietetiques.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(6), 463-5

The "Finnish Diabetes Prevention Study" is a prospective controlled study recently published in the New England Journal of Medicine which compared the risk of developing type 2 diabetes among 265 high ... [more ▼]

The "Finnish Diabetes Prevention Study" is a prospective controlled study recently published in the New England Journal of Medicine which compared the risk of developing type 2 diabetes among 265 high-risk patients treated by changes in lifestyle to that of 257 matched controlled patients. This intervention trial demonstrated that the risk of type 2 diabetes could be reduced by 58% (p < 0.001) after a mean follow-up of 3.2 years with changes in lifestyle of high-risk overweight subjects with impaired glucose tolerance. [less ▲]

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See detailIsolation of Clostridium perfringens from three neonatal calves with haemorrhagic abomasitis.
Manteca, C.; Jauniaux, Thierry ULg; Daube, Georges ULg et al

in Revue de Médecine Vétérinaire (2001), 152

Braxy-like disease with sudden death and acute haemorhagic abomasitis was diagnosed in three Belgian Blue calves : one two-day-old and one one month-old calves, in good condition with no clinical signs ... [more ▼]

Braxy-like disease with sudden death and acute haemorhagic abomasitis was diagnosed in three Belgian Blue calves : one two-day-old and one one month-old calves, in good condition with no clinical signs noted a few hours prior to death, and another two day-old calf, which had shown problems of abomasal dilatation and regurgitation prior to death. Histologically, the abomasal wall were oedematous and emphysematous. A pure and abundant growth of Clostridium perfringens was obtained in anaerobic conditions from the abomasal wall of the three Belgian Blue calves. No bacterial growth was obtained in aerobic conditions. The calf with digestive disorders was also positive for BVD virus by immunofluorescence in the abomasal wall and in the spleen. [less ▲]

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See detailPharma-clinics. Le medicament du mois. Le repaglinide (NovoNorm).
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(6), 456-9

Repaglinide (NovoNorm) is an antidiabetic oral agent of the new glinide class with insulinotropic activity. Its action on insulin secretion is more rapid and shorter than that of sulphonylurea compounds ... [more ▼]

Repaglinide (NovoNorm) is an antidiabetic oral agent of the new glinide class with insulinotropic activity. Its action on insulin secretion is more rapid and shorter than that of sulphonylurea compounds. Thanks to these properties, repaglinide is able to better control postprandial hyperglycaemia and is associated with a lower risk of delayed hypoglycaemic episodes. It is indicated for the treatment of type 2 (non-insulin-dependent) diabetes mellitus as monotherapy, after diet failure, or in combination with metformin, when the biguanide is insufficient. NovoNorm is commercialized as tablets of 0.5, 1 and 2 mg, to be taken just before each meal. Initial dosis should be 0.5 mg before meal in diabetic patients on diet alone or 1 mg before meal in patients already receiving an hypoglycaemic agent. If necessary, the dosis should be progressively increased, depending on the individual response, up to 4 mg before meal (maximal daily dosage of 16 mg), in order to optimize blood glucose control. [less ▲]

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See detailContributions to early land plant research (XIV IBC).
Gerrienne, Philippe ULg; Berry, Christopher M.

in Review of Palaeobotany and Palynology (2001), 116

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See detailUn sujet obese par une approche multidisciplinaire: l'exemple du Centre de l'Obesite du CHU Ourthe-Ambleve.
Scheen, André ULg; Rorive, Marcelle ULg; Letiexhe, Michel ULg et al

in Revue Médicale de Liège (2001), 56(7), 474-9

Obesity is a mulfactorial disease whose prevalence is progressively increasing. Ideally, it requires a multidisciplinary management by medical doctors, dieticians, psychologists and kinetherapists. The ... [more ▼]

Obesity is a mulfactorial disease whose prevalence is progressively increasing. Ideally, it requires a multidisciplinary management by medical doctors, dieticians, psychologists and kinetherapists. The new "Centre de l'Obesite" at the University of Liege aims at fulfilling such objectives with: 1) a first outpatient visit including the simultaneous participation of an endocrinologist, a dietician and a psychologist; 2) a structured and individualized programme of physical rehabilitation; 3) an individualized management of obese subjects as in-(hospital) and/or outpatients, using medical and/or surgical approaches; and 4) an opportunity to benefit of other specialized medical advices, if necessary, in order to increase both the efficacy and safety of the treatment. Owing to the increasing importance of obesity and the well-known difficulties to succeed in treating it, general practitioners should consider this new centre as a valuable help rather than a competitive structure for the management of their patients, especially those with severe or morbid obesity. [less ▲]

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See detailAarabia, a new Early Devonian vascular plant from Africa (Morocco).
Gerrienne, Philippe ULg; Meyer-Berthaud, Brigitte

in Review of Palaeobotany and Palynology (2001), 116

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See detailVademecum pour la bonne pratique d'une activite physique.
Scheen, André ULg; Crielaard, Jean-Michel ULg

in Revue Médicale de Liège (2001), 56(5), 396-400

The present closing article summarizes some guidelines for the good practice of physical activities in order to develop and maintain cardiorespiratory and muscular fitness, and flexibility. Advice is ... [more ▼]

The present closing article summarizes some guidelines for the good practice of physical activities in order to develop and maintain cardiorespiratory and muscular fitness, and flexibility. Advice is given regarding the recommended quantity and quality of exercise in term of intensity, duration and frequency of training with the aim to optimize the risk/benefit ratio for health, in both aerobic endurance and resistance exercises. The crucial role of an appropriate warm-up and cool-down period, which would include flexibility exercises, is also emphasized. Finally, some practical examples illustrate this vademecum of physical activities. [less ▲]

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See detailShelf-slope exchanges associated with a steep submarine canyon off Calvi (Corsica, NW Mediterranean Sea): A modelling approach
Skliris, Nikos; Goffart, Anne ULg; Hecq, Jean-Henri ULg et al

in Journal of Geophysical Research (2001), 106(C9), 19883-19901

A three-dimensional, unsteady, nonlinear, high-resolution model is used to investigate the impact of the Calvi Canyon (NW Corsica) steep topography on the shelf-slope exchanges as well as on the ... [more ▼]

A three-dimensional, unsteady, nonlinear, high-resolution model is used to investigate the impact of the Calvi Canyon (NW Corsica) steep topography on the shelf-slope exchanges as well as on the circulation in the Calvi Bay in homogeneous winter and early spring conditions. A double σ coordinate system is considered in order to represent adequately the high depth gradients within the canyon. The studied region is under the influence of the West Corsica Current flowing northeastward along the NW Corsican coast (right-bounded flow). Model results show that the circulation in the Calvi Bay is determined by flow modifications in the canyon area. The mean horizontal flow is deviated southwestward upstream of the canyon to form an anticyclonic gyre in the western part of the Calvi Bay. Within the canyon the circulation is cyclonic leading to an offshore flow downstream of the canyon. Around the canyon rim, the cross-shelf currents become important, indicating that this region acts as a transition zone of high exchange between nearshore and offshore areas. Furthermore, the canyon topography generates high downwelling (upwelling) and downsloping (upsloping) velocities responsible for an intense vertical transport of material in the area. Numerical runs are performed for typical prevailing wind conditions. The wind is responsible for a drastic increase of cross-shore transports between the bay and the canyon area (3–4 times larger than in the no-wind case). SW winds induce a further enhancement of cross-shelf exchanges, whereas the effect of N-NE winds is to reduce exchange at the shelf break apart from the canyon head where an intense offshore flow occurs. Within the canyon, high vertical velocities are shown to be associated with high cyclonic vorticity which is enhanced (reduced) by the N-NE (SW) wind event. A comparison between model results and measured distributions of nitrate and chlorophyll a concentrations in the area shows the role played by this specific hydrodynamics as a strong constraint on the coastal pelagic ecosystem. [less ▲]

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See detailQuantitative cell dispersion analysis: new test to measure tumor cell aggressiveness
Nawrocki-Raby, Béatrice; Polette, Myriam; Gilles, Christine ULg et al

in International Journal of Cancer = Journal International du Cancer (2001), 93(5), 644-52

Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between ... [more ▼]

Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between cell dispersion and cell invasion, related respectively to expression of E-cadherin/catenin complex and matrix metalloproteinases (MMPs), we developed an original in vitro model of cell dispersion analysis. Our study reports the validation of this model that allowed us to analyze and quantify the cell cohesion level by means of time-lapse videomicroscopy and computer analysis based on the observation of spatial and temporal cell distribution. Our model was able to distinguish 2 groups among different human bronchial and mammary epithelial cells previously characterized for the expression of E-cadherin/catenin complex and MMPs and their invasive capacity in the Boyden chamber assay. The first group (16HBE14o-, MCF-7, T47D) that expressed membranous E-cadherin and -catenin, and was negative for MMP-2 expression and non-invasive, displayed a highly cohesive pattern corresponding to a cluster spatial distribution. The second group (Beas2B, BZR, BZR-T33, MDA-MB-231, MDA-MB-435, BT549 and HS578T) that was invasive and showed lack of expression of E-cadherin and a cytoplasmic redistribution of -catenin, displayed a dispersed pattern corresponding to a random spatial distribution. Downregulation of E-cadherin by a blocking antibody induced a more random distribution. Conversely, expression of E-cadherin by cDNA transfection induced a cluster distribution. Moreover, tumor cell lines that co-expressed MT1-MMP and MMP-2 (Beas2B, BZR, BZR-T33, MDA-MB-435, BT549 and HS578T) showed a more dispersed pattern than tumor cell lines that did not express MMP-2 (MDA-MB-231). In conclusion, we demonstrated that the spatial group behavior of cell lines, i.e., their cohesion/dispersion ability, reflects their invasive properties. Thus, this model of cell dispersion analysis may represent a new test to measure tumor cell aggressiveness. [less ▲]

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See detailRadiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?
Zouhair, A; COUCKE, Philippe ULg; Jeanneret, W et al

in European Journal of Cancer (2001), 37

Abstract To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of ... [more ▼]

Abstract To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35±76 years). According to the International Union Against Cancer (UICC) 1997 classi®cation, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classi®cation was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20±331 months). In a median period of 12 months (range 5±139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy postoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5- and 10-year survival rates were 57% (95% con®dence interval (CI), 41±73%) and 38% (95% CI, 21± 55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41±73%) and 48% (95% CI, 32±64%), respectively. In patients treated with primary radiotherapy, 5- and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22±50%) and 18% (95% CI, 2±34%), respectively. In multivariate analyses, survival was signi®cantly in¯uenced by the N-classi®- cation, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squa- mous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no di erence in terms of survival between patients treated by surgery and those treated by primary radiotherapy salvage surgery, with 39% having organ preservation. [less ▲]

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See detailIron bacterial and fungal mats, Bajocian stratotype (Mid-Jurassic, northern Normandy, France)
Préat; Mamet, B.; De Ridder, C. et al

in Sedimentary Geology (2001), 137

The Oolithe ferrugineuse de Bayeux Formation is located at the historical Bajocian stratotype of Sainte-Honorine-des-Pertes, north of Bayeux, Normandy. The condensed formation ranges from the base of the ... [more ▼]

The Oolithe ferrugineuse de Bayeux Formation is located at the historical Bajocian stratotype of Sainte-Honorine-des-Pertes, north of Bayeux, Normandy. The condensed formation ranges from the base of the Humphriesianum Zone to the Parkinsoni Zone and is divided into four beds of decimetric scale. Three main microfacies are present: (1) oncoid rudstones, (2) ooid bioclastic packstones and (3) silty burrowed wackestones/ packstones. Sedimentation took place in a very quiet environment, below the photic zone and below or near the storm wave base. The general setting is a distal carbonate ramp, its lower part characterized by hemipelagic sedimentation indicated by the presence of planktonic foraminifers. The inferred depth is around 100 m. Free oxygen concentration was low. Dysaerobic conditions are indicated by a scarcity of benthic macrofauna. Ferruginous structures are numerous in the first two microfacies, and absent in the last. Hematite staining is not uniform and follows many sedimentary patterns. Among the more widespread Fe structures are perforation infillings with endolithic microorganisms, microstromatolites, oncoids, ooids, blisters, coatings and hardgrounds. These structures can be associated and none are mutually exclusive. Hematite-coated filaments of different sizes and shapes are observed in the micrite matrix: the walls of various organisms; the calcite crystals associated with the Fe cortical laminations; the perforations and burrow; the hardgrounds; and microstromatolites. Petrographical and SEM examinations suggest that the laminated crusts (oncoids and hardgrounds) are formed by microbial iron mats dominated by filamentous bacteria and fungi. Seven types of microbes are recognized: filaments (five morphotypes), spheroidal bodies and stalked bodies. Filamentous microfossils of type 1 to 4 resemble the present-day filamentous bacteria (Beggiatoales and Cytophagaceae). Because of their large diameter and their branching nature, filaments of type 5 are possibly filamentous fungi. Another argument in favor of fungi is the presence of stalked and spheroidal bodies that resemble zoosporangia and oogonia of some Oomycota. In deep, calm and dysaerobic waters, many interfaces (e.g. between aerobic and dysaerobic waters) are present in the sediments. The stability of the soluble reduced state of iron (Fe2+) is higher at such interfaces, and many ferric iron-encrusted microbial fossils are observed. Iron could thus serve as an electron donor for microbial iron-oxidation processes. Other microbial iron deposition pathways are also possible. It appears that, regardless of geological age (Paleozoic, Mesozoic) and geographical location, the same microbiological mechanisms are probably responsible for the red color in calcareous stratified or unstratified bodies. The presence of fossilized iron-encrusted bacteria and fungi at interfaces may therefore serve as an indicator of anoxic to dysaerobic conditions in various paleo(micro)environments. [less ▲]

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See detailIntervalle entre vêlage chez la vache Borgou au Benin
Adamou-N'Diaye, M.; Ogodija, O. J.; Gbangboche, A. B. et al

in Annales de Médecine Vétérinaire (2001), 145(2), 130-136

This retrospective study has been carry out in the Monastery bovine exploitation of Kokoubou (department of Borgou in Benin). Data were collected and analysed from individual cow records of 1967 to 1989 ... [more ▼]

This retrospective study has been carry out in the Monastery bovine exploitation of Kokoubou (department of Borgou in Benin). Data were collected and analysed from individual cow records of 1967 to 1989. It concerned 150 Borgou cows and 838 calving intervals. The following parameters have been determined: monthly frequency of calving and calving interval. Monthly frequencies of calving are not regrouped in rainy season. Calving intervals have decreased with lactation numbers, while the season presents no effect. [less ▲]

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See detailN content of phloem and xylem exudates during the transition to flowering in Sinapis alba and Arabidopsis thaliana
Corbesier, Laurent; Havelange, Andrée ULg; Lejeune, Pierre et al

in Plant, Cell & Environment (2001), 24

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower ... [more ▼]

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower by one long day (LD). In S. alba, the phloem sap (leaf and apical exudates) and the xylem sap (root exudate) were analysed in LD versus SD. In A. thaliana, only the leaf exudate could be analysed but an alternative system for inducing flowering without day-length extension was used: the displaced SD (DSD). Significant results are: (i) in both species, the leaf exudate was enriched in Gln during the inductive LD, at a time compatible with export of the floral stimulus; (ii) in S. alba, the root export of amino acids decreased in LD, whereas the nitrate remained unchanged - thus the extra-Gln found in the leaf exudate should originate from the leaves; (iii) extra-Gln was also found very early in the apical exudate of S. alba in LD, together with more Glu; (iv) in A. thaliana induced by one DSD, the leaf export of Asn increased sharply, instead of Gln in LD. This agrees with Asn prevalence in C-limited plants. The putative role of amino acids in the transition to flowering is discussed. [less ▲]

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See detailGenèse, évolution et multiples facettes d'une maladie inhabituelle affectant le hêtre en région wallonne
Huart, Olivier; Rondeux, Jacques ULg

in Forêt Wallonne (2001), 52

Les hêtraies wallonnes, principalement situées en Ardenne et en Gaume, sont victimes depuis près de 2 ans d'un problème sanitaire dont l'incidence au plan sylvicole et économique apparaît réellement ... [more ▼]

Les hêtraies wallonnes, principalement situées en Ardenne et en Gaume, sont victimes depuis près de 2 ans d'un problème sanitaire dont l'incidence au plan sylvicole et économique apparaît réellement catastrophique depuis le début de l'année 2001. Une recherche entamée mi-2000 a permis d'effectuer de très nombreuses observations et d'émettre diverses hypothèses quant à l'origine et au processus de développement d'une maladie mettant en jeu des champignons lignivores et des insectes ravageurs du bois. Cette recherche entre aujourd'hui dans sa seconde phase destinée non seulement à assurer le suivi méthodique de la maladie mais aussi à vérifier le bien-fondé des principales hypothèses émises concernant son origine et à cerner les mécanismes de propagation d'insectes dont les attaques n'ont cessé de croître depuis mars 2001. Ces attaques massives ont justifié la mise en place d'actions de recherche complémentaires et plus ciblées destinées à mieux comprendre la biologie des insectes incriminés et de proposer des moyens de lutte appropriés. Dans les lignes qui suivent nous présentons, sur la base d'observations menées depuis 10 mois, une analyse relativement fouillée de la situation en abordant successivement : l'historique de cette maladie, sa distribution, les symptômes les plus fréquemment observés ainsi que les agents causals, les axes prioritaires des recherches en cours, les conséquences tant économiques que sylvicoles et écologiques, et enfin les principaux moyens de lutte envisageable, compte tenu de l'état actuel des connaissances. [less ▲]

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See detailTOWNSCOPE II - A computer system to support solar access decision-making
Teller, Jacques ULg; Azar, Sleiman ULg

in International Journal of Solar Energy (2001), 70/3

TOWNSCOPE II is a computer system devoted to support solar access decision-making in a sustainable urban design perspective. The software consists of a three-dimensional urban information system coupled ... [more ▼]

TOWNSCOPE II is a computer system devoted to support solar access decision-making in a sustainable urban design perspective. The software consists of a three-dimensional urban information system coupled with solar evaluation tools. We’ve paid particular attention to the fact that numerical results interpretation proves to be all but trivial in complex built environments. It is nevertheless a crucial aspect in decision-making, especially for current negotiated urban design practices. Which is why developing visual instruments in order to unveil the geometrical mechanisms lying behind the final results. Various spherical projections were thereby developed, each of them presenting specific advantages and disadvantages for solar access visualisation and/or evaluation purposes. [less ▲]

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See detailContinued benefit of coronary stenting versus balloon angioplasty: five-year clinical follow-up of Benestent-I trial.
Kiemeneij, F.; Serruys, P. W.; Macaya, C. et al

in Journal of the American College of Cardiology (2001), 37(6), 1598-603

OBJECTIVES: This study sought to establish whether the early favorable results in the Benestent-I randomized trial comparing elective Palmaz-Schatz stent implantation with balloon angioplasty in 516 ... [more ▼]

OBJECTIVES: This study sought to establish whether the early favorable results in the Benestent-I randomized trial comparing elective Palmaz-Schatz stent implantation with balloon angioplasty in 516 patients with stable angina pectoris are maintained at 5 years. BACKGROUND: The size of the required sample was based on a 40% reduction in clinical events in the stent group. Seven months and one-year follow-up in this trial showed a decreased incidence of restenosis and clinical events in patients randomized to stent implantation. METHODS: Data at five years were collected by outpatient visit, via telephone and via the referring cardiologist. Three patients in the stent group and one in the percutaneous transluminal coronary angioplasty (PTCA) group were lost to follow-up at five years. Major clinical events, anginal status and use of cardiac medication were recorded according to the intention to treat principle. RESULTS: No significant differences were found in anginal status and use of cardiac medication between the two groups. In the PTCA group, 27.3% of patients underwent target lesion revascularization (TLR) versus 17.2% of patients in the stent group (p = 0.008). No significant differences in mortality (5.9% vs. 3.1%), cerebrovascular accident (0.8% vs. 1.2%), myocardial infarction (9.4% vs. 6.3%) or coronary bypass surgery (11.7% vs. 9.8%) were found between the stent and PTCA groups, respectively. At five years, the event-free survival rate (59.8% vs. 65.6%; p = 0.20) between the stent and PTCA groups no longer achieved statistical significance. CONCLUSIONS: The original 10% absolute difference in TLR in favor of the stent group has remained unchanged at five years, emphasizing the long-term stability of the stented target site. [less ▲]

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See detailCore-shell-corona micelles with a responsive shell
Gohy, Jean-François; Willet, Nicolas ULg; Varshney, Sunil et al

in Angewandte Chemie (International ed. in English) (2001), 40(17), 3214-3216

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See detailMultivariate statistics for wildlife and ecology research
Bogaert, Jan ULg

in Acta Biotheoretica (2001), 49(2), 141-143

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See detail“Dismembered Histories: Slavery and Silence in Dennis Scott’s An Echo in the Bone and Ina Césaire’s Mémoires d’Isles.”
Bada, Valérie ULg

in Journal of the Midwest Modern Language Association (2001)

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See detailA recombinant beta-O-glucosidase from Caldocellum saccharolyticum to hydrolyse desulfo-glucosinolates
Wathelet, Jean-Paul ULg; Iori, R.; Leoni, O. et al

in Biotechnology Letters (2001), 23(6), 443-446

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum ... [more ▼]

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum saccharolyticum does not catalyse glucosinolate degradation but can hydrolyse desulfo-glucosinolates (thio-D-glucosidic substrates) to produce the corresponding pure nitriles, including valuable homochiral representatives. [less ▲]

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See detailLes tourbières analysées en profondeur par le radar de subsurface.
Wastiaux, C; Halleux, L; Schumacker, R et al

in Hautes Fagnes (2001), 243

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See detailFurther investigation of the supervisory attentional system in schizophrenia: Planning, inhibition, and rule abstraction
Marczewski, P.; Van der Linden, Martial ULg; Laroi, Frank ULg

in Cognitive Neuropsychiatry (2001), 6(3), 175-192

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational ... [more ▼]

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational level were compared. Three tasks (Tower of London, Hayling, and Brixton tests) were used to examine 3 executive processes (planning, inhibition, and rule detection). Schizophrenic patients performed significantly worse than normal controls on all 3 tasks. In addition, patients' performances on selected measures of the three tests were correlated, even when age and medication were partialled out. It is concluded that patients are impaired on all SAS functions. The possible role of a general impairment (processing speed or cognitive resources) is discussed [less ▲]

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See detailStand der osteoporose-Therapie. Ein Medizinischer Skandal
Reginster, Jean-Yves ULg

in MMW Fortschritte der Medizin (2001), 143(14), 43

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See detailExperience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep
Laureys, Steven ULg; Peigneux, Philippe ULg; Phillips, Christophe ULg et al

in Neuroscience (2001), 105(3), 521-525

One function of sleep is hypothesized to be the reprocessing and consolidation of memory traces (Smith, 1995; Gais et al., 2000; McGaugh, 2000; Stickgold et al., 2000). At the cellular level, neuronal ... [more ▼]

One function of sleep is hypothesized to be the reprocessing and consolidation of memory traces (Smith, 1995; Gais et al., 2000; McGaugh, 2000; Stickgold et al., 2000). At the cellular level, neuronal reactivations during post-training sleep in animals have been observed in hippocampal (Wilson and McNaughton, 1994) and cortical (Amzica et al., 1997) neuronal populations. At the systems level, using positron emission tomography, we have recently shown that some brain areas reactivated during rapid-eye-movement sleep in human subjects previously trained on an implicit learning task (a serial reaction time task) (Maquet et al., 2000). These cortical reactivations, located in the left premotor area and bilateral cuneus, were thought to reflect the reprocessing - possibly the consolidation - of memory traces during post-training rapid-eye-movement sleep. Here, the experience-dependent functional connectivity of these brain regions is examined. It is shown that the left premotor cortex is functionally more correlated with the left posterior parietal cortex and bilateral pre-supplementary motor area during rapid-eye-movement sleep of subjects previously trained to the reaction time task compared to rapid-eye-movement sleep of untrained subjects. The increase in functional connectivity during post-training rapid-eye-movement sleep suggests that the brain areas reactivated during post-training rapid-eye-movement sleep participate in the optimization of the network that subtends subject's visuo-motor response. The optimization of this visuo-motor network during sleep could explain the gain in performance observed during the following day. [less ▲]

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See detailPharmacology of the Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor Bm-531
Dogné, J. M.; Rolin, S.; de Leval, X. et al

in Cardiovascular Drug Reviews (2001), 19(2, Summer), 87-96

BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its ... [more ▼]

BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its affinity for human washed platelet TXA2 receptors labeled with [3H]SQ-29548 (IC50 = 0.0078 microM) is higher than sulotroban (IC50 = 0.93 microM) and SQ-29548 (IC50 = 0.021 microM). Moreover, BM-531 is characterized by a potent antiaggregatory property. Indeed, on one hand, in human citrated platelet-rich plasma BM-531 prevents platelet aggregation induced by arachidonic acid (600 microM) (ED100 = 0.125 microM), U-46619, a stable TXA2 agonist (1 microM) (ED50 = 0.482 microM) or collagen (1 microgram/mL) (percentage of inhibition: 42.9% at 10 microM) and inhibits the second wave of ADP (2 microM)-induced aggregation. On the other hand, when BM-531 is incubated in whole blood from healthy donors, the closure time measured by the recently developed platelet function analyser (PFA-100) is significantly prolonged. In addition, at the concentrations of 10 and 1 microM, BM-531 totally prevents the production of TXB2 by human platelets activated by arachidonic acid. Finally, at 10 microM, BM-531 significantly prevents rat fundus contractions induced by U-46619 but not by prostacyclin. These results suggest that BM-531, which is devoid of the diuretic property of torasemide, can be regarded as a promising antiplatelet agent. [less ▲]

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See detailThe Insulin-Sensitive Side of SHIP2
Schurmans, Stéphane ULg

in TheScientificWorldJournal (2001), 1

A substantial and increasing proportion of death and disability in the EU (and elsewhere) is attributable to diseases associated with insulin resistance (i.e., decreased insulin sensitivity). Beside type ... [more ▼]

A substantial and increasing proportion of death and disability in the EU (and elsewhere) is attributable to diseases associated with insulin resistance (i.e., decreased insulin sensitivity). Beside type II diabetes, other diseases like obesity, hypertension, atherosclerosis, hyperlipidaemia, polycystic ovarian syndrome, and acromegaly are indeed associated with insulin resistance [less ▲]

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See detailRt-Pcr-Elosa Tests On Pooled Sample Units For The Detection Of Virus Y In Potato Tubers
Chandelier, Anne; Dubois, Nathalie ULg; Baelen, Frédéric et al

in Journal of Virological Methods (2001), 91(2), 99-108

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See detailPiaget e Skinner : opposizioni e convergenze
Richelle, Marc ULg

in Età Evolutiva (2001), 70

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See detailUmetnost Čarlsa Simića
Delville, Michel ULg

in ProFemina : Časopis za żensku knjiżevnost I kulturu (2001), 27

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See detailReduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: another indication of abnormal sensory processing?
Ambrosini, A.; De Pasqua, Victor ULg; Afra, J. et al

in Neuroscience Letters (2001), 306(1-2), 132-4

Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The ... [more ▼]

Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The amplitude of the P50 response to the second of two homologous stimuli was significantly less reduced in migraineurs than in healthy volunteers. This lack of auditory sensory gating may be due to a hypofunction of monoaminergic subcortico-cortical pathways, which is also supposed to cause the interictal deficit of cortical habituation to repetitive stimuli. [less ▲]

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See detailDoes F2 need a hard pomeron?
Cudell, Jean-René ULg; Soyez, G.

in Physics Letters B (2001), 516

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See detailCommentaire
Richelle, Marc ULg

in Intellectica (2001), 32

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