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See detailControverses thérapeutiques: le traitement de la maladie de Basedow
Khalife, A.; Valdes Socin, Hernan Gonzalo ULg; Beckers, Albert ULg

in Revue Médicale de Liège (1999), 54(7), 606-610

Hyperthyroidism is a common clinical condition with an annual incidence of about 1%. Approximately, 1 in every 20 women will develop this condition during a lifetime. Most cases are due to Graves'disease ... [more ▼]

Hyperthyroidism is a common clinical condition with an annual incidence of about 1%. Approximately, 1 in every 20 women will develop this condition during a lifetime. Most cases are due to Graves'disease. Solitary toxic nodules and toxic multinodular goiters are also important but less frequent causes. In this article, we will consider only the treatment of Graves'disease. Anti-thyroid drugs, surgery and radio-iodine, all represent effective forms of treatment. There is, however, little consensus regarding the treatment of choice for specific cases. This article discusses the advantages and disadvantages of each treatment. [less ▲]

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See detailA RED discard strategy for ATM networks and its performance evaluation with TCP/IP Traffic
Rosolen, Vincent; Bonaventure, Olivier; Leduc, Guy ULg

in Computer Communication Review (1999), 29(3), 23-43

In ATM UBR networks supporting TCP traffic, optimal efficiency can only be envisaged if switches adopt a discard mechanism that operates at the packet level rather than the cell level. In this paper, we ... [more ▼]

In ATM UBR networks supporting TCP traffic, optimal efficiency can only be envisaged if switches adopt a discard mechanism that operates at the packet level rather than the cell level. In this paper, we define a variant of the RED discard strategy suitable for ATM switches. An interesting feature of this ATM-RED is that it has a similar per-VC implementation complexity as the Early Packet Discard (EPD) algorithm. To study the efficiency of the ATM-RED discard strategy, we compare its performance with plain the UBR, EPD and Fair Buffer Acceptance (FBA) discard strategies by means of simulation with TCP/IP traffic. We give comparative results with respect to different performance criteria such as goodput and fairness in various environments, such as end-to-end ATM networks and IP-based networks with an ATM backbone, in both single-bottlenecked and GFC topologies. [less ▲]

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See detailHuman Muscle Energetics During Voluntary and Electrically Induced Isometric Contractions as Measured by 31p Nmr Spectroscopy
Vanderthommen, Marc ULg; Gilles, R.; Carlier, Pierre ULg et al

in International Journal of Sports Medicine (1999), 20(5), 279-83

Electrical stimulation (ES) and voluntary contraction (VC) were compared in the quadriceps muscle of ten male volunteers. In both modes, a workload corresponding to 20% of maximal voluntary contraction ... [more ▼]

Electrical stimulation (ES) and voluntary contraction (VC) were compared in the quadriceps muscle of ten male volunteers. In both modes, a workload corresponding to 20% of maximal voluntary contraction was applied during 64 isometric contraction (5.5 s)-relaxation (5.5 s) cycles. The protocols were performed in a 1.5 T whole-body magnet. The Pi/PCr ratio and the intracellular pH (pHi) were monitored by 31P NMR spectroscopy during baseline, exercise and recovery periods, in a superficial region of the vastus medialis. During baseline, the Pi/PCr ratio (0.12 vs. 0.10) and the pHi (7.01 vs. 7.00) were comparable in both conditions. During exercise, the Pi/PCr ratio was higher (0.36 vs. 0.14) and the pHi was lower (6.85 vs. 7.07) during ES than during VC. For the same external work production, these results reflect a different metabolic solicitation in the ES quadriceps than in the VC ones. [less ▲]

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See detailSynthesis of novel polybutadiene-graft-poly(sodium methacrylate) amphiphilic copolymers as precursors for liquid crystalline graft copolymers
Gohy, Jean-François; Charlier, Christelle; Zhang, Jian-Xin et al

in Macromolecular Chemistry and Physics (1999), 200(7), 1630-2638

Well-defined polybutadiene-graft-poly(tert-butyl methacrylate) (PBD-g-PtBMA) copolymers were prepared by reaction of PtBMA chains end-capped with a tert-butyl 4-vinylbenzoate (tBVB) anion, with the ... [more ▼]

Well-defined polybutadiene-graft-poly(tert-butyl methacrylate) (PBD-g-PtBMA) copolymers were prepared by reaction of PtBMA chains end-capped with a tert-butyl 4-vinylbenzoate (tBVB) anion, with the selectively hydrosilylated 1,2-units of anionically synthesized PBD. Substitution of the tBVB anion for the anion of living PtBMA chains is required for the formation of the expected C-silylation product instead of the unstable O-silylation one. Subsequent hydrolysis of the poly(tert-butyl methacrylate) grafts followed by neutralization of the carboxylic acid groups by sodium hydroxide leads to amphiphilic polybuta-diene-graft-poly(sodium methacrylate) (PBD-g-PNaMA) graft copolymers. These copolymers form unimeric micelles in water, as observed by dynamic light scattering (DLS). Non-covalent liquid crystalline graft copo-lymers were prepared by cation exchange between PBD-g-PNaMA copolymers and an ammonium containing smectic mesogen. These copolymers form a smectic mesophase which is microphase separated from PBD. [less ▲]

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See detailAortic Valve Replacement in the Octogenarians: Perioperative Outcome and Clinical Follow-Up
Kolh, Philippe ULg; Lahaye, Laurent; Gérard, Paul ULg et al

in European Journal of Cardio - Thoracic Surgery (1999), 16(1), 68-73

OBJECTIVES: To determine long-term results of aortic valve replacement (AVR) in patients 80 years old or older, and assess the factors influencing perioperative outcome. METHODS: Data were reviewed on 83 ... [more ▼]

OBJECTIVES: To determine long-term results of aortic valve replacement (AVR) in patients 80 years old or older, and assess the factors influencing perioperative outcome. METHODS: Data were reviewed on 83 consecutive octogenarians, undergoing aortic valve replacement between 1992 and 1997. There were 66 women and 17 men (mean age: 82.8 years). Fifty-seven patients (69%) were in New York Heart Association (NYHA) class III-IV and six had previous myocardial infarction. Three patients had previous percutaneous aortic valvuloplasty. There were 19 urgent procedures (23%). Coronary artery bypass grafting (CABG) was performed on 21 patients (25%). Possible influence of preoperative and operative variables on early and late mortality was performed with univariate and multivariate statistical analysis, and survival was estimated with the Kaplan-Meier method. RESULTS: Operative mortality was 13% (9% for AVR, 24% for AVR-CABG). Postoperative complications were respiratory failure in 19 patients, atrial fibrillation in 19, hemodialysis in four, myocardial infarction in four and stroke in two patients. Five patients required pacemaker insertion for permanent atrioventricular block. Median hospital stay and intensive care unit stay were 19.8 +/- 12.2 days and 7.9 +/- 3.4 days, respectively. Multivariate predictors of hospital death (P < 0.05) were percutaneous aortic valvuloplasty, NYHA class IV, and urgent procedure. Mean follow-up was 26.5 months. Survival at 1, 2, and 5 years was 98.5 +/- 1.4% (63 patients at risk), 93.4 +/- 3.2% (47 patients at risk), and 78.2 +/- 6.9% (six patients at risk), respectively. Preoperative myocardial infarction and urgent procedure were independent predictors of late death. At most recent follow-up, 91% were angina free and 81% were in class I-II. CONCLUSIONS: Aortic valve replacement in octogenarians can be performed with acceptable mortality. These results stress the importance of early operation on elderly patients with aortic valve disease. Both long-term survival and functional recovery are excellent. [less ▲]

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See detailEffect of exercise and COPD crisis on isoprostane concentration in plasma and bronchoalveolar lavage fluid in horses
Kirschvink, Nathalie; Art, Tatiana ULg; Smith, Nicola et al

in Equine Veterinary Journal. Supplement (1999), 30

To test whether isoprostanes could be used as markers of oxidative stress in horses, their concentration was determined in plasma and in pulmonary epithelial lining fluid (PELF) in 3 models of oxidative ... [more ▼]

To test whether isoprostanes could be used as markers of oxidative stress in horses, their concentration was determined in plasma and in pulmonary epithelial lining fluid (PELF) in 3 models of oxidative stress: (1) strenuous exercise, (2) acute COPD crisis and (3) exercise combined with COPD crisis. Four horses were investigated twice, once in crisis and once in remission. The animals underwent a standardised treadmill exercise test. Isoprostane assessment was performed in plasma and bronchoalveolar lavage fluid 24 h before and 1 h after exercise and in plasma also immediately after exercise. Exercise in remission induced a significant increase of isoprostanes in plasma and in PELF. In horses in crisis, the isoprostane concentrations did not increase in plasma, while they did increase in PELF. Lastly, exercise in crisis increased plasma levels of isoprostanes, but did not change PELF isoprostanes. In conclusion, 1) isoprostanes are increased by systemic oxidative stress induced by strenuous exercise in COPD horses in remission either in PELF or in plasma; 2) only PELF and not plasma isoprostanes are increased by pulmonary oxidative stress induced by COPD crisis and 3) unexpectedly, exercise in crisis increased plasma but not PELF isoprostanes. [less ▲]

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See detailPhonological loop and central executive functioning in Alzheimer's disease
Collette, Fabienne ULg; Van der Linden, Martial ULg; Bechet, Sophie ULg et al

in Neuropsychologia (1999), 37(8), 905-918

The phonological loop and central executive functioning were examined in patients with Alzheimer's disease (AD) and in normal elderly subjects. AD patients showed abnormal functioning of the phonological ... [more ▼]

The phonological loop and central executive functioning were examined in patients with Alzheimer's disease (AD) and in normal elderly subjects. AD patients showed abnormal functioning of the phonological loop and decreased performance on tasks assessing the central executive. However, when AD patients were separated into two groups on the basis of their span level, both groups showed deficits of the central executive but only patients with the lower span level presented a dysfunction of the phonological loop as well as impaired performance in tasks of phonological discrimination, articulation rate and speed of processing. These results are interpreted in terms of progression of the disease, with high-span level patients being less severely demented and displaying deficits only in higher-level cognitive functions (such as manipulation of information stored in working memory) whereas patients with a low span level have impairments encompassing a series of more basic processes. [less ▲]

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See detailImages du mois. Quel est votre diagnostic? Une balanite aigue
Nikkels, Arjen ULg

in Revue Médicale de Liège (1999), 54(7), 634-635

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See detailControverses dans le traitement de l'Helicobacter pylori
Van Kemseke, Catherine ULg; Belaiche, Jacques ULg

in Revue Médicale de Liège (1999), 54(7), 570-5

Helicobacter pylori is a worldwide infection. In gastro-duodenal ulcer disease no doubt remains about the necessity of H. pylori eradication. Controversies subsisting in other pathologies such gastro ... [more ▼]

Helicobacter pylori is a worldwide infection. In gastro-duodenal ulcer disease no doubt remains about the necessity of H. pylori eradication. Controversies subsisting in other pathologies such gastro-esophageal reflux, dyspepsia, gastritis, gastric adenocarcinoma or MALT lymphoma are reviewed. Multiple drug combinations have been proposed to cure the infection. These are discussed in the clinical setting of Belgian practice. [less ▲]

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See detailLes Migrations en Chine : Implications sur le plan
Florence, Eric ULg

in Hommes & Migrations (1999), (n° 1220), 73-95

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See detailLa douce ivresse du chêne
Quin, Jean-Philippe; Jourez, Benoît ULg

in Forêt Wallonne (1999), 43

Il est une des applications du bois de chêne qui déchaîne les passions et en magnifie la matière. Nous voulons bien sûr faire référence à la tonnellerie, cet artisanat de qualité intimement lié à la ... [more ▼]

Il est une des applications du bois de chêne qui déchaîne les passions et en magnifie la matière. Nous voulons bien sûr faire référence à la tonnellerie, cet artisanat de qualité intimement lié à la culture européenne depuis plusieurs siècles et symbole de la communion entre la vigne et l'arbre. [less ▲]

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See detailNonlinear analysis of cardiac rythm fluctuations using DFA method
Absil, P.-A.; Sepulchre, Rodolphe ULg; Bilge, A. et al

in Physica A: Statistical Mechanics and its Applications (1999), 272

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See detailObituary : GEORGES ADINS
Sacré, Robert ULg

in Soul Bag (1999), (155), 47

Nécrologie de Georges ADINS ; photo

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See detailLes critères de convergence du Traité de Maastricht et la consolidation de la dette publique
Husson, Jean-François ULg; Steylaers, Jean-Luc

in Bulletin de Documentation du Ministère des Finances (1999), 59(4), 3-45

This articles analyses various operations on and around the Belgian public debt in order to match the Maastricht criteria.

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See detailChirurgie versus angioplastie des artères coronaires
Legrand, Victor ULg; Martinez, Christophe ULg

in Revue Médicale de Liège (1999), 54(7), 593-9

Revascularization techniques such as coronary angioplasty or coronary artery bypass surgery play a growing role in the management of coronary artery disease. Angioplasty is the treatment of choice for ... [more ▼]

Revascularization techniques such as coronary angioplasty or coronary artery bypass surgery play a growing role in the management of coronary artery disease. Angioplasty is the treatment of choice for single coronary lesions while surgery remains the best approach for the revascularization of multivessel disease. There are some exceptions to this rule, however. Bypass surgery may be recommended for the revascularisation of proximal left anterior descending lesions and, of course, for isolated left main stenosis. On the opposite, coronary angioplasty and stenting is used more frequently in the treatment of multivessel lesions amenable to this technique. Choice of either method of revascularization is pragmatic, based on clinical, anatomical and physiological considerations and organized in the setting of a medicosurgical collaboration. [less ▲]

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See detailJ.J. MALONE
Sacré, Robert ULg

in Soul Bag (1999), (155), 68

Photo J.J. MALONE , Ecaussinnes 15 mai 1999

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See detailUse of a Monoclonal Antibody against an Escherichia coli O26 Surface Protein for Detection of Enteropathogenic and Enterohemorrhagic Strains
Kerr, Paul; Ball, Hywell; China, Bernard et al

in Clinical and Vaccine Immunology (1999), 6(4), 610-614

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See detailCardiac myxoma in a 6-year-old child--constitutional symptoms mimicking rheumatic disease and the role of interleukin-6.
Hovels-Gurich, H. H.; SEGHAYE, Marie-Christine ULg; Amo-Takyi, B. K. et al

in Acta Paediatrica (1999), 88(7), 786-8

A 6-y-old girl with right atrial myxoma presented with remittent fever attacks, general arthralgia and laboratory investigations mimicking rheumatic or autoimmune disease. Interleukin-6 (IL-6) serum ... [more ▼]

A 6-y-old girl with right atrial myxoma presented with remittent fever attacks, general arthralgia and laboratory investigations mimicking rheumatic or autoimmune disease. Interleukin-6 (IL-6) serum concentration was markedly elevated before and normal after tumour resection, whereas myxoma cells stained negatively for IL-6. IL-6 should be considered a myxoma marker: overproduction by myxoma cells and consecutive systemic passage are assumed to cause immunological features. [less ▲]

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See detailDoppler Echocardiographic Study of Left and Right Ventricular Function During Dobutamine Stress Testing in Conscious Healthy Dogs
Mc Entee, Kathleen ULg; Clercx, Cécile ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1999), 60(7), 865-71

OBJECTIVE: To evaluate left and right ventricular filling and ejection performances by use of Doppler echocardiography in healthy, conscious dogs submitted to dobutamine stress testing. ANIMALS: 10 ... [more ▼]

OBJECTIVE: To evaluate left and right ventricular filling and ejection performances by use of Doppler echocardiography in healthy, conscious dogs submitted to dobutamine stress testing. ANIMALS: 10 unsedated, healthy adult Beagles. PROCEDURE: Doppler echocardiography was performed during cardiac stress testing on each dog twice at 24-hour intervals. Dobutamine was infused in 10 micrograms/kg of body weight/min incremental dosages, from 12.5 to 42.5 micrograms/kg/min. Duration of each step was 15 minutes. Doppler measurements were recorded at baseline and at each stage of dobutamine infusion, whereas aortic diameter was measured at baseline and at peak dosage by use of two-dimensional echocardiography. RESULTS: Dobutamine infusion induced a significant increase in velocity time integrals and in peak flow velocities at the aortic, pulmonic, mitral, and tricuspid valves. Acceleration time-to-deceleration time ratio at the aortic wave also was increased significantly. On the other hand, ejection time, acceleration time, and deceleration time at the aortic and pulmonic valves and peak flow velocity of the E wave-to-peak flow velocity of the A wave ratio at the mitral and tricuspid valves decreased significantly during the test. The acceleration time-to-deceleration time ratio at the pulmonic wave was unchanged. A significant, progressive increase in cardiac index also was observed during dobutamine infusion, with a maximal increase of 104% from baseline. This was mediated initially by an increase in stroke index and, at higher dosages, by an increase in heart rate. CONCLUSIONS AND CLINICAL RELEVANCE: Doppler echocardiography performed during dobutamine stress testing may be a reliable method of assessing myocardial function in dogs with cardiovascular disease. [less ▲]

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See detailPersistent hyperplastic primary vitreous: MRI.
Kuker, W.; RAMAEKERS, Vincent ULg

in Neuroradiology (1999), 41(7), 520-2

Persistent hyperplastic primary vitreous (PHPV), a developmental cause of leukocoria, is due to incomplete regression of the fetal blood supply to the eye. We report the MRI features of PHPV of the dorsal ... [more ▼]

Persistent hyperplastic primary vitreous (PHPV), a developmental cause of leukocoria, is due to incomplete regression of the fetal blood supply to the eye. We report the MRI features of PHPV of the dorsal type to facilitate differential diagnosis from other causes of leukocoria, namely retinoblastoma, which may have major therapeutic consequences. [less ▲]

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See detailLe point sur les nouveautés apportées au CWATUP
Delnoy, Michel ULg

in Immobilier (1999), 12

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See detailFractal Analysis of Mercury Porosimetry Data in the Framework of the Thermodynamic Method
Sahouli, B; Blacher, Silvia ULg; Pirard, René ULg et al

in Journal of Colloid & Interface Science (1999), 214(2), 450-454

The thermodynamic method for fractal analysis is applied to mercury intrusion data. The results for representative commercial carbon black samples and a series of resorcinol-formaldehyde (RF) freeze-dried ... [more ▼]

The thermodynamic method for fractal analysis is applied to mercury intrusion data. The results for representative commercial carbon black samples and a series of resorcinol-formaldehyde (RF) freeze-dried gels for different values of the molar ratio of resorcinol (R) to catalyst (C) are discussed in relation with the type of behavior exhibited by the samples during mercury porosimetry measurements. The obtained surface fractal dimensions are compared with those derived previously from the small-angle X ray scattering (SAXS) and the nitrogen adsorption. Copyright 1999 Academic Press. [less ▲]

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See detailA New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells
Grooteclaes, Madeleine; Vernimmen, Douglas; Plaza, S. et al

in Cancer Research (1999), 59(11), 2527-31

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene ... [more ▼]

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene transcription. We report the identification of a new 17-bp-long cis sequence located between positions -506 and -489 from the transcription start site. This sequence is recognized by a trans-activating factor that we tentatively named HER2 transcription factor (HTF). This factor, involved in the increased transcription of the HER2 gene in the BT-474 mammary tumor cells, has a molecular weight of about Mr 50,000. HTF can also bind, but with a lower affinity, to a related cis sequence present in the epidermal growth factor receptor promoter. Interestingly, the HTF binding activity is high in nuclear extracts from several mammary tumor cells overexpressing the HER2 gene. [less ▲]

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See detailThe n-Zipf analysis of financial data series and biased data series
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physica A: Statistical Mechanics and its Applications (1999), 268(1-2), 240-249

The Zipf analysis of n-words in random sequences and financial data series like the stock prices of a company has been performed. The bias as well as the resulting staircase structure of the Zipf plots ... [more ▼]

The Zipf analysis of n-words in random sequences and financial data series like the stock prices of a company has been performed. The bias as well as the resulting staircase structure of the Zipf plots are taken into account in the subsequent analysis. It is found that correlations for the sign of the fluctuations as well as for the amplitude of the fluctuations can be found in financial time series. The relevance of the n-Zipf analysis to financial sequences is underlined to be only weakly predictive for a "binary transformation level", but could be more interesting for "higher translation levels". [less ▲]

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See detailA 2.3 Day Periodic Variability in the Apparently Single Wolf-Rayet Star WR 134: Collapsed Companion or Rotational Modulation?
Morel, Thierry ULg; Marchenko, Sergey V; Eenens, Philippe R J et al

in Astrophysical Journal (1999), 518

The apparently single WN 6 type star WR 134 (HD 191765) is distinguished among the Wolf-Rayet star population by its strong, presumably cyclical (P~2.3 day) spectral variations. A true periodicity-which ... [more ▼]

The apparently single WN 6 type star WR 134 (HD 191765) is distinguished among the Wolf-Rayet star population by its strong, presumably cyclical (P~2.3 day) spectral variations. A true periodicity-which is still very much debated-would render WR 134 a prime candidate for harboring either a collapsed companion or a rotating, large-scale, inhomogeneous outflow. We have carried out an intensive campaign of spectroscopic and photometric monitoring of WR 134 from 1989 to 1997 in an attempt to reveal the true nature of this object. This unprecedentedly large data set allows us to confirm unambiguously the existence of a coherent 2.25+/-0.05 day periodicity in the line-profile changes of He II lambda4686, although the global pattern of variability is different from one epoch to another. This period is only marginally detected in the photometric data set. Assuming the 2.25 day periodic variability to be induced by orbital motion of a collapsed companion, we develop a simple model that aims to investigate (1) the effect of this strongly ionizing, accreting companion on the Wolf-Rayet wind structure, and (2) the expected emergent X-ray luminosity. We argue that the predicted and observed X-ray fluxes can only be matched if the accretion on the collapsed star is significantly inhibited. Additionally, we performed simulations of line-profile variations caused by the orbital revolution of a localized, strongly ionized wind cavity surrounding the X-ray source. A reasonable fit is achieved between the observed and modeled phase-dependent line profiles of He II lambda4686. However, the derived size of the photoionized zone substantially exceeds our expectations, given the observed low-level X-ray flux. Alternatively, we explore rotational modulation of a persistent, largely anisotropic outflow as the origin of the observed cyclical variability. Although qualitative, this hypothesis leads to greater consistency with the observations. [less ▲]

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See detailQuelle promotion de la santé en milieu de travail ?
Mairiaux, Philippe ULg

in Education Santé (1999), (139), 12-14

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See detailCharacterization of the Insulin-Like Growth Factor Axis in the Human Thymus
Kecha, Ouafae; Martens, Henri ULg; Franchimont, Nathalie et al

in Journal of Neuroendocrinology (1999), 11(6), 435-40

The components of the insulin-like growth factor (IGF) axis have been investigated in the normal human thymus. Using ribonuclease protection assays (RPA), IGF-II transcripts were detected in the normal ... [more ▼]

The components of the insulin-like growth factor (IGF) axis have been investigated in the normal human thymus. Using ribonuclease protection assays (RPA), IGF-II transcripts were detected in the normal human thymus. By reverse transcriptase polymerase chain reaction (RT-PCR) analyses, promoters P3 and P4 were found to be active in the transcription of IGF2 gene within human thymic epithelial cells (TEC). No IGF-II mRNA could be detected in human lymphoid Jurkat T cells with 30 cycles of RT-PCR. By Northern blot analyses, IGFBP-2 to -6 (but not IGFBP-1) were found to be expressed in TEC with a predominance of IGFBP-4. Interestingly, Jurkat T cells only express IGFBP-2 but at high levels. The type 1 IGF receptor was detected in Jurkat T cells but not in human TEC. The identification of the components of the IGF axis within separate compartments of the human thymus adds further evidence for a role of this axis in the control of T-cell development. The precise influence of thymic IGF axis upon T-cell differentiation and immunological self-tolerance however needs to be further investigated. [less ▲]

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See detailElectrochemical study of uranium exchange on a polypyrrole resin
Jérôme, Christine ULg; Martinot, Lucien; Jérôme, Robert ULg

in Journal of Radioanalytical & Nuclear Chemistry (1999), 240(3), 969-972

The ability to electrochemically control the binding of uranium ions by redox active polypyrrole resins has been studied. The optimization of the conditions for the fixation of uranium has been defined ... [more ▼]

The ability to electrochemically control the binding of uranium ions by redox active polypyrrole resins has been studied. The optimization of the conditions for the fixation of uranium has been defined while taking in account the nature of the fixed species, the nature of the resin and the nature of the solutions. [less ▲]

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See detailGuiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark of Strychnos Guianensis
Penelle, J.; Tits, Monique ULg; Christen, P. et al

in Journal of Natural Products (1999), 62(6), 898-900

A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by ... [more ▼]

A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by detailed spectroscopic methods and comparison with model compounds. [less ▲]

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See detailCompatibilization of immiscible polymer blends (PV/PVDF) by the addition of a third polymer (PMMA): analysis of phase morphology and mechanical properties
Moussaif, Noureddin; Jérôme, Robert ULg

in Polymer (1999), 40(14), 3919-3932

Compatibilization of the immiscible polycarbonate (PC)/polyvinylidenefluoride (PVDF) pair by a third homopolymer, i.e. polymethylmethacrylate (PMMA), was studied in relation to phase morphology and ... [more ▼]

Compatibilization of the immiscible polycarbonate (PC)/polyvinylidenefluoride (PVDF) pair by a third homopolymer, i.e. polymethylmethacrylate (PMMA), was studied in relation to phase morphology and mechanical properties of the polyblends. Scanning electron microscopy showed a more regular and finer phase dispersion when the original PMMA content in PVDF exceeded 20 wt.%. The premixing of PVDF with ca. 40 wt.% PMMA also had a beneficial effect on mechanical properties, such as ultimate tensile strength, elongation at break, and notched impact strength. All these experimental results are consistent with the interfacial activity of PMMA in the PC/PVDF blends. [less ▲]

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See detailLa qualité de la relation avec les patients : un des éléments du bien-être des soignants à l'hôpital
Vandoorne, Chantal ULg; Müller, Michel; Mairiaux, Philippe ULg

in Bulletin d'Education du Patient à sa Maladie (1999), 18(2), 47-50

L’étude exploratoire décrite dans cet article s’intègre dans le programme du réseau belge francophone des «Hôpitaux promoteurs de santé». Elle a pour objectif général d’identifier les besoins en matière ... [more ▼]

L’étude exploratoire décrite dans cet article s’intègre dans le programme du réseau belge francophone des «Hôpitaux promoteurs de santé». Elle a pour objectif général d’identifier les besoins en matière de santé du personnel hospitalier, première étape d’un processus de mobilisation du personnel et de la hiérarchie en faveur de la promotion de la santé à l’hôpital. Une enquête qualitative a été menée au CHU de Liège sur base d’entretiens de groupe et d’entretiens individuels. Cette enquête montre que les besoins de santé du personnel sont liés au vécu quotidien du travail et impliquent essentiellement des facteurs matériels et des facteurs psychosociaux parmi lesquels on retrouve la qualité de la relation avec les patients et leur information. Les pistes d’action prioritaires émergeant de cette enquête concernent l’organisation du travail, la gestion des ressources humaines, mais aussi une politique effective de communication vers les patients. Dans le cadre du réseau francophone des «Hôpitaux promoteurs de santé», cette étude a également pour objectif la mise au point d’un instrument d’enquête généralisable aux autres hôpitaux. [less ▲]

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See detailCo-construire la qualité: dispositif et démarche
Pirard, Florence ULg

in Génération ONE (1999), 6

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See detailPurification and Characterization of the Heat-Labile Alpha-Amylase Secreted by the Psychrophilic Bacterium Tac 240b
Chessa, Jean-Pierre; Feller, Georges ULg; Gerday, Charles ULg

in Canadian Journal of Microbiology (1999), 45(6), 452-7

A total of 59 bacteria samples from Antarctic sea water were collected and screened for their ability to produce alpha-amylase. The highest activity was recorded from an isolate identified as an ... [more ▼]

A total of 59 bacteria samples from Antarctic sea water were collected and screened for their ability to produce alpha-amylase. The highest activity was recorded from an isolate identified as an Alteromonas species. The purified alpha-amylase shows a molecular mass of about 50,000 Da and a pI of 5.2. The enzyme is stable from pH 7.5 to 9 and has a maximal activity at pH 7.5. Compared with other alpha-amylases from mesophiles and thermophiles, the "cold enzyme" displays a higher activity at low temperature and a lower stability at high temperature. The psychrophilic alpha-amylase requires both Cl- and Ca2+ for its amylolytic activity. Br- is also quite efficient as an allosteric effector. The comparison of the amino acid composition with those of other alpha-amylases from various organisms shows that the cold alpha-amylase has the lowest content in Arg and Pro residues. This could be involved in the principle used by the psychrophilic enzyme to adapt its molecular structure to the low temperature of the environment. [less ▲]

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See detailLe caractère paroxysmal
Stassart, Martine ULg

in Information Psychiatrique (L') (1999), 75(6), 603-610

Since the introduction of electroencephalography in 1930, epilepsy and his "equivalents" have migrated from the field of psychiatry to that of neurology. A great number of psychiatric clinical pictures ... [more ▼]

Since the introduction of electroencephalography in 1930, epilepsy and his "equivalents" have migrated from the field of psychiatry to that of neurology. A great number of psychiatric clinical pictures remain nevertheless marked by the scal of comitiality and dominated by what Szondi called "paroxysmality". By integrating epilepsy in his pulsional pattern, Szondi has contributed to its being maintened in the psychiatric field. His own work, based on his test and that of Françoise Minkowska, based on the Rorschach test, help in early recognition of the signs of this common, paroxysmal illness, of which little is known ans which is therefore badly treated. [less ▲]

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See detailExploration of implicit artificial grammar learning in Parkinson's disease
Peigneux, Philippe ULg; Meulemans, Thierry ULg; Van der Linden, Martial ULg et al

in Acta Neurologica Belgica (1999), 99(2), 107-117

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See detailComplexation of uranyl ion by three polyacrylamide type polymers: electrochemical preparation and leaching tests investigations
Leroy, D.; Martinot, Lucien; Jérôme, Christine ULg et al

in Journal of Radioanalytical & Nuclear Chemistry (1999), 240(3), 867-875

describe an original process for the treatment of low level activity radioactive liquid wastes. It deals with the electrochemical preparation of three polyacrylate polymers: polyacrylamide (PAam ... [more ▼]

describe an original process for the treatment of low level activity radioactive liquid wastes. It deals with the electrochemical preparation of three polyacrylate polymers: polyacrylamide (PAam), polyacrylamidoglycolic acid (PAAG), polyacrylamidomethylpropanesulfonic acid (PAMPS) which are capable of complexing uranyl ions. We have demonstrated the complexation of uranyl by FT-IR and UV-Visible spectroscopy. All these complexes are soluble in water and we insolubilize in turn the complexes by crosslinking or by neutralization of positively charged complexes by the addition of polyanions to the medium. We have then done dynamic and static leaching tests on these insoluble complexes. [less ▲]

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See detailPrévention de la fibrillation auriculaire récidivante et resynchronisation bi-atriale
Evrard, P.; Sakalihasan, Natzi ULg; Garcia, R. et al

in Revue Médicale de Liège (1999), 54(6), 522-6

After conversion of atrial fibrillation, it is important to maintain sinus rhythm. In addition antiarrhythmic drugs, biatrial resynchronization seems to prevent recurrences of atrial fibrillation in ... [more ▼]

After conversion of atrial fibrillation, it is important to maintain sinus rhythm. In addition antiarrhythmic drugs, biatrial resynchronization seems to prevent recurrences of atrial fibrillation in patients with interatrial conduction block: local experience. [less ▲]

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See detailHeterogeneity of the eae Genes in Attaching/Effacing Escherichia Coli from Cattle: Comparison with Human Strains
China, B.; Jacquemin, E.; Devrin, A. C. et al

in Research in Microbiology (1999), 150(5), 323-332

Enteropathogenic (EPEC) and enterohaemorrhagic (EHEC) Escherichia coli isolated from cattle were studied by DNA colony hybridization to subtype their intimin-encoding (eae) gene with probes derived from ... [more ▼]

Enteropathogenic (EPEC) and enterohaemorrhagic (EHEC) Escherichia coli isolated from cattle were studied by DNA colony hybridization to subtype their intimin-encoding (eae) gene with probes derived from the variable parts of the eae alpha gene of the human EPEC strain E2348/69, the eae gamma gene of the human O157:H7 EHEC strain ATCC43888, and the eae beta gene of the bovine O26:H- EHEC strain 193, whose eae gene was first cloned and sequenced during this work. The EPEC and EHEC had been isolated from diarrhoeic calves (143 EPEC and 48 EHEC) and from healthy animals at the slaughterhouse (10 EPEC and 34 EHEC). The 191 bovine EPEC and EHEC isolated from diseased calves were positive with the Eae beta probe (55 and 27% respectively) and with the Eae gamma probe (9 and 73% respectively), whereas 52 EPEC (36%) were negative with the Eae alpha, Eae beta, and Eae gamma probes. The results were different for the 44 bovine EPEC and EHEC isolated from healthy cattle at slaughterhouses: most tested positive with the Eae gamma probe (80 and 82% respectively) and the remaining (20 and 18% respectively) with the Eae beta probe. Nine O26 human EHEC tested positive with the Eae beta probe and seven O111 with the Eae gamma probe. The bovine and human EPEC and EHEC belonging to these two serogroups gave identical results: the 18 bovine and human O26 isolates tested positive with the Eae beta probe, whereas the 13 O111 isolates were positive with the Eae gamma probe. In contrast, the isolates belonging to other serogroups (O5, O15, O18, O20, and O118) gave more variable results. The eae beta and eae gamma, but not the eae alpha, variants were thus distributed amongst bovine EPEC and EHEC. The eae beta variant seemed to be more frequently associated with the presence of clinical signs in calves, but one third of EPEC from diarrhoeic calves carried an eae gene variant other than the alpha, beta, or gamma variants. In addition, the use of these gene probes did not enable differentiation between bovine and human EHEC belonging to the same O serogroup. [less ▲]

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See detailLes besoins de santé du personnel du CHU de Liège
Müller, Michel; Vandoorne, Chantal ULg; Mairiaux, Philippe ULg

in Education santé (1999), (139), 41-43

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See detailHomocysteine et risque cardio-vasculaire
Lutteri, Laurence ULg; Chapelle, Jean-Paul ULg; Gielen, Jean-Louis ULg

in Revue Médicale de Liège (1999), 54(6), 541-7

Homocystinuria is an uncommon genetic disease characterized by a marked increase of serum homocysteine (HCY), an intermediate of methionine metabolism. In patients with homocystinuria ... [more ▼]

Homocystinuria is an uncommon genetic disease characterized by a marked increase of serum homocysteine (HCY), an intermediate of methionine metabolism. In patients with homocystinuria, hyperhomocysteinemia promotes the development of atherosclerotic lesions and is responsible for premature coronary artery disease. Recently, several studies have also demonstrated that moderate hyperhomocysteinemia--not necessarily linked to an inborn metabolic defect--may also be considered as an independant risk factor for cardiovascular disease. The main mechanisms of HCY atherogenic action are thought to be LDL oxydation, inhibition of vascular endothelium growth combined with stimulation of smooth muscular cells proliferation, and interference with the coagulation and fibrinolytic systems. Cofactors of key enzymes in HCY metabolism, folic acid, vitamin B12 and vitamin B6, may be given, alone or in combination, for the treatment of hyperhomocysteinemia. Homocysteinemia can be assessed by basal plasma HCY concentration and/or by HCY levels measured after a methionine loading test. Mainly measured till now in specialized laboratories using rather complex techniques (HPLC, GCMS, amino acid analyser ...), HCY determination is today spreading widely owing to the development of automated immunoassays. [less ▲]

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See detailEditorial - Réseaux et protocoles
Garavel, Hubert; Leduc, Guy ULg; Groz, Roland

in Technique et Science Informatiques (1999), 18(6),

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See detailSomatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis.
Poncin, Jacques ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in European Journal of Endocrinology (1999), 140(6), 573-6

Pituitary adenomas are a common manifestation of multiple endocrine neoplasia type 1 (MEN1) but most of them occur sporadically. There are only a few well defined genetic abnormalities known to occur in ... [more ▼]

Pituitary adenomas are a common manifestation of multiple endocrine neoplasia type 1 (MEN1) but most of them occur sporadically. There are only a few well defined genetic abnormalities known to occur in these sporadic tumours. The MEN1 gene located on 11q13 has recently been cloned and allelic deletion and mutation analysis studies have implicated the MEN1 gene in a significant fraction of the sporadic counterparts of typical MEN1 neoplasms (parathyroid tumours, insulinomas and gastrinomas). To determine if MEN1 gene inactivation is also involved in the development of sporadic pituitary adenomas, allelic deletions of chromosome 11q13 and MEN1 gene mutations and polymorphisms were assessed in 35 sporadic tumours of the anterior pituitary (9 prolactin-secreting, 8 GH-secreting, 3 TSH-secreting, 2 TSH/GH-secreting, 4 Cushing, 9 silent). Thirty-one tumours were found to be heterozygous for at least one MEN1 intragenic polymorphism (25 cases) or for a flanking gene polymorphism (6 cases). The remaining tumours were not informative. No mutations were found in any tumour except in one prolactinoma which was homozygous or hemizygous for a mutation (1-117 C-->T) in a region close to the promoter. Unfortunately, blood or normal tissue was not available in this case. Our data show that somatic MEN1 mutations do not contribute significantly to tumorigenesis of sporadic pituitary adenomas and suggest that mutation of other genes are likely to contribute to the pathogenesis of these tumours. [less ▲]

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See detailDirect observation of microdomain morphology in "all-acrylic" thermoplastic elastomers synthesized via living radical polymerization
Leclère, Philippe; Moineau, Georges; Minet, Michaël et al

in Langmuir (1999), 15(11), 3915-3919

We investigate the microscopic morphology of thin films of symmetric triblock copolymers synthesized via a two-step “living” radical polymerization of n-butylacrylate and methyl methacrylate. These ... [more ▼]

We investigate the microscopic morphology of thin films of symmetric triblock copolymers synthesized via a two-step “living” radical polymerization of n-butylacrylate and methyl methacrylate. These copolymers with low poly(methyl methacrylate) contents constitute a new class of potential thermoplastic elastomers with higher service temperature and oxidation resistance compared to conventional polydiene−polystyrene-based thermoplastic elastomers. The straightforward synthetic pathway allows for strict control of molecular weight, molecular-weight distribution, and composition. The presence in the copolymer of immiscible segments covalently bound to each other leads to phase separation on the nanometer scale. Regular organization of the phase-separated nanodomains is observed in real space by scanning force microscopy. The data point to a strong contrast in the local mechanical properties, corresponding to the microphase morphology. Cylinders of the minority phase are found to orient perpendicular to the surface, because of the surface energy difference between the constituents. Lamellae are also arranged perpendicular to the surface, in contrast to what is usually observed in block copolymers. This particular orientation is thought to result from the symmetric character of these triblock systems, with the outer blocks more polar than the central sequence. [less ▲]

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See detailNouvel outil d'aménagement du territoire en Wallonie - le SDER
Delnoy, Michel ULg

in Immobilier (1999), 9

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See detailGrafts of Meningeal Fibroblasts in Adult Rat Spinal Cord Lesion Promote Axonal Regrowth
Franzen, Rachelle ULg; Martin, Didier ULg; Daloze, A. et al

in Neuroreport (1999), 10(7), 1551-6

We have studied the morphological consequences of implantation into the injured adult rat spinal cord of fibroblasts derived from the meninges overlying the cerebral cortex. Our initial objective was to ... [more ▼]

We have studied the morphological consequences of implantation into the injured adult rat spinal cord of fibroblasts derived from the meninges overlying the cerebral cortex. Our initial objective was to reproduce the well known post-traumatic fibroadhesive scar observed in the clinical situation. One month after implantation, instead of having formed a fibroadhesive scar, fibroblasts had promoted the regeneration of peptidergic axons originating from dorsal root afferents and, to a lesser extent, of supraspinal serotonergic fibers at the periphery of the grafts. Using RT-PCR we were able to identify in cultures of meningeal-derived fibroblasts mRNAs for beta-NGF, NT3, aFGF and bFGF, which suggests that the promoting effect on axonal regeneration of these cells is at least in part due to their capacity to synthesize neurotrophic factors. [less ▲]

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See detailKronig-Penney-Ising picture of colossal magnetoresistance
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg; Cloots, Rudi ULg

in Physical Review. B : Condensed Matter (1999), 59(18), 11909-11913

From general arguments, it is shown that a magnetic Kronig-Penney model based on the thermodynamics of an Ising model can be used for describing the colossal magnetoresistance (CMR) phenomenon. The model ... [more ▼]

From general arguments, it is shown that a magnetic Kronig-Penney model based on the thermodynamics of an Ising model can be used for describing the colossal magnetoresistance (CMR) phenomenon. The model considers a tunneling like transmission process of hopping electrons through a dynamic lattice characterized by evolving magnetic clusters. In this model, correlations between the magnetic states are considered to be more relevant than the lattice strain effects for obtaining the CMR features. Physical arguments lead to the theoretical description of the intrinsic temperature and field dependences of the CMR observed in typical manganite materials. [less ▲]

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See detailThe Interacting Early-Type Binary BD +40°4220 (V729 Cyg): Modeling the Colliding Winds Region
Rauw, Grégor ULg; Vreux, Jean-Marie ULg; Bohannan, B.

in Astrophysical Journal (1999), 517

We present an analysis of an extensive set of spectroscopic observations of the mysterious early-type binary BD +40 deg4220. A new orbital solution is derived from the radial velocities of the absorption ... [more ▼]

We present an analysis of an extensive set of spectroscopic observations of the mysterious early-type binary BD +40 deg4220. A new orbital solution is derived from the radial velocities of the absorption lines. We confirm that the secondary star is highly overluminous for its mass. The absorption lines of both components display phase-locked profile variations, with some of the secondary's lines going into emission between phi=0.20 and phi=0.55. A detailed investigation of the profile variability of the He II lambda4686 emission line reveals that the pattern of variability of this line is very stable. We show that part of the He II lambda4686 emission is produced in the wind interaction region between the stars. Most of the emission lines in the visual spectrum of BD +40 deg4220 display variations that are reminiscent of those observed on the He II lambda4686 line, pointing toward a similar origin. We present numerical simulations of emission-line profiles in a colliding winds binary, showing that an important part of the variability observed in BD +40 deg4220 can be explained by a colliding winds phenomenon. The properties of the wind interaction region can be accounted for if we assume that the secondary star is an evolved object, most probably some kind of Ofpe/WN9 transition star, with a mass loss rate of ~5.5x10^-6 M_solar yr^-1. We finally discuss the fundamental parameters of the binary, concluding that mass transfer must have played a crucial role in the evolution of this system. [less ▲]

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See detailA second-order theory for resonance capture in corotation centers
Beauge, C.; Lemaitre, Anne; Jancart, Sylvie ULg

in Planetary and Space Science (1999), 47

In this paper we revisit the analytical determination of the corotation solutions of the restricted planar three-body problem under the effects of a Stokes drag. Previous calculations by different authors ... [more ▼]

In this paper we revisit the analytical determination of the corotation solutions of the restricted planar three-body problem under the effects of a Stokes drag. Previous calculations by different authors, and using different external dissipative forces, have always shown significant quantitative errors of the models with respect to the numerical values. Up to date no concrete explanation has been obtained for this discrepancy. We show that the origin of these errors lies not only in the modelization of the gravitational forces (i.e. disturbing function) but in the averaging process of the variational equations. A second-order averaging is developed based on a Lie transform method ([Kamel, 1969]). With it we can calculate new equilibrium solutions with a greatly improved accuracy. In a second part, this same perturbation method is applied to study the periodic orbits (i.e. limit cycles) which describe the motion of the particles around the averaged corotational solutions. We show how analytical approximations of these cycles can be obtained through the inverse transformation of the averaging process itself. In all cases, we present comparisons with numerical simulations of the exact equations. [less ▲]

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See detailDetermination of pregnancy-associated glycoprotein concentrations in goats (Capra hircus) with unsuccessful pregnancies: a retrospective study
Zarrouk, A.; Engeland, I.; Sulon, Joseph ULg et al

in Theriogenology (1999), 51(7), 1321-31

Presented here are the profiles of pregnancy-associated glycoprotein (PAG) concentrations in blood collected weekly from goats experiencing maintained and unsuccessful pregnancies. The analysis of these ... [more ▼]

Presented here are the profiles of pregnancy-associated glycoprotein (PAG) concentrations in blood collected weekly from goats experiencing maintained and unsuccessful pregnancies. The analysis of these profiles clearly indicated 4 different situations: the pseudopregnancy syndrome, abortion between Days 89 and 137, parturition of 1 dead and 1 live fetus, and expulsion of macerated or mummified fetuses after full term. A marked reduction in PAG concentration at any time during pregnancy was followed by an event such as abortion or the expulsion of a dead fetus at term or later. [less ▲]

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See detailVisualizing the log-periodic pattern before crashes
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg; Boveroux, P. et al

in European Physical Journal B -- Condensed Matter (1999), 9(2), 355-359

We present a method for visualizing the pattern which we believe to be a precursor signature of financial crashes (or ruptures). The log-periodicity of the pattern is investigated through the envelope ... [more ▼]

We present a method for visualizing the pattern which we believe to be a precursor signature of financial crashes (or ruptures). The log-periodicity of the pattern is investigated through the envelope function technique. Three periods of the Down Jones Industrial Average (DJIA) are investigated: 1982-1987, 1992-1997 and 1993-1998. The presence of a rupture in the end of 1998 is outlined from data taken before the end of August 1998. [less ▲]

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See detailArrangement of phases and heating constraints in a busbar
Hedia, Hakim; Henrotte, François; Meys, Benoït et al

in IEEE Transactions on Magnetics (1999), 35(3), 1274-1277

This paper presents the analysis of a busbar for a three-phase system. The best connection of the different phases is proposed to derive the optimal dissipation of the heat flux inside the busbar. The ... [more ▼]

This paper presents the analysis of a busbar for a three-phase system. The best connection of the different phases is proposed to derive the optimal dissipation of the heat flux inside the busbar. The implementation of a magnetothermal coupled model which can take into account radiation exchange and the electric circuit parameters is necessary. A comparison of numerical results with experimental results is made on an industrial busbar. [less ▲]

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See detailA General and Natural Method to Define Circuit Relations Associated with Magnetic Vector Potential Formulations
Dular, Patrick ULg; Henrotte, François; Legros, Willy

in IEEE Transactions on Magnetics (1999), 35(3), 1630-1633

A procedure is proposed to deal with magnetic vector potential finite element magnetodynamic formulations and the definition of their associated circuit relations, involving voltages and currents ... [more ▼]

A procedure is proposed to deal with magnetic vector potential finite element magnetodynamic formulations and the definition of their associated circuit relations, involving voltages and currents, especially for massive inductors. It consists in solving two successive problems thanks to the use of edge elements, the first problem releasing the second one, which is especially useful for efficient nonlinear time stepping analyses [less ▲]

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See detailAnabolic Events in Osteoarthritis
Henrotin, Yves ULg; Reginster, Jean-Yves ULg

in Osteoarthritis and Cartilage (1999), 7(3), 310-2

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See detailEpidemiological Typing of Extended-Spectrum Beta-Lactamase-Producing Klebsiella Pneumoniae Isolates by Pulsed-Field Gel Electrophoresis and Antibiotic Susceptibility Patterns
Chetoui, H.; Delhalle, E.; Melin, Pierrette ULg et al

in Research in Microbiology (1999), 150(4), 265-72

Over a 16-month period, Klebsiella pneumoniae isolates from 102 patients admitted to a university hospital in Liege (Belgium) produced extended-spectrum beta-lactamases. Pulsed-field gel electrophoresis ... [more ▼]

Over a 16-month period, Klebsiella pneumoniae isolates from 102 patients admitted to a university hospital in Liege (Belgium) produced extended-spectrum beta-lactamases. Pulsed-field gel electrophoresis of genome macrorestriction patterns with XbaI and antibiotic susceptibility patterns subdivided 39 isolates into eight clonally related groups. Two of them were implicated in the course of this outbreak. They were responsible for successive waves of infection or colonization in different wards of the hospital while the others were encountered sporadically. A beta-lactamase with an isoelectric point of 7.6 and consistent with type SHV-2 characterized all nine isolates chosen among both major groups. [less ▲]

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See detailUse of the Enteroscope for Colo-Ileoscopy: Low Yield in Unexplained Lower Gastrointestinal Bleeding
Belaiche, Jacques ULg; Van Kemseke, Catherine ULg; Louis, Edouard ULg

in Endoscopy (1999), 31(4), 298-301

BACKGROUND AND STUDY AIMS: The small intestine is a potential origin of bleeding in patients with unexplained gastrointestinal tract hemorrhage or iron-deficiency anemia. Most reports on the investigation ... [more ▼]

BACKGROUND AND STUDY AIMS: The small intestine is a potential origin of bleeding in patients with unexplained gastrointestinal tract hemorrhage or iron-deficiency anemia. Most reports on the investigation of these patients describe the use of upper tract enteroscopy. The diagnostic yield of combined upper and lower enteroscopy has not been widely assessed and remains to be clarified. The aim of this study was to assess the benefit of lower gastrointestinal tract enteroscopy in occult digestive bleeding. PATIENTS AND METHODS: Between 1 December 1995 and 15 January 1998, 54 patients with gastrointestinal bleeding of unknown origin were prospectively studied using upper and lower video push enteroscopy (44 for chronic iron-deficiency anemia and 10 for unexplained gastrointestinal tract hemorrhage with no potential site having been identified by other investigations). Examinations were done using a Olympus video enteroscope (SIF-100) under general anesthesia in a one-day clinic. An upper tract examination was done first, directly followed by the lower tract investigation. RESULTS: The upper tract enteroscopy was successful in 53 patients (98%) and retrograde ileoscopy in 21 patients (39%). In 18 (38%) cases the technical failure resulted from the impossibility of intubating the ileocecal valve. A potential source of upper gastrointestinal bleeding was detected in 35% of patients with chronic iron-deficiency anemia and in 20% of those with unexplained gastrointestinal tract hemorrhage. The most common lesion in the small bowel was angiodysplasia (25%). The lower tract video push enteroscopy disclosed 11 lesions in patients with chronic anemia. However the lesions, including two ileocecal valve cancers, were mainly located in the colon and had been missed by previous colonoscopy. No case of ileal lesion was detected in this group of patients. In patients with unexplained gastrointestinal tract hemorrhage, three lesions were detected but only one of these was in the ileum. Associated colonic and jejunal lesions were observed in three patients (5.5%). Overall, the diagnostic yield of lower video push enteroscopy was less than 2%. CONCLUSION: This prospective study has shown that using an enteroscope as a colonoscope in the management of patients with gastrointestinal bleeding of unknown origin is of little help. It might actually be more appropriate to perform a second colonoscopy. This however remains controversial and a prospective study is needed to answer that question. [less ▲]

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See detailFamilial Acromegaly: Case Report and Review of the Literature
Verloes, Alain ULg; Stevenaert, Achille ULg; Teh, B. T. et al

in Pituitary (1999), 1(3-4), 273-277

Familial acromegaly is an exceptional clinical entity when not associated with features of multiple endocrine neoplasia type 1 (MEN1). We report here 3 pedigrees in each of which 2 patients have been ... [more ▼]

Familial acromegaly is an exceptional clinical entity when not associated with features of multiple endocrine neoplasia type 1 (MEN1). We report here 3 pedigrees in each of which 2 patients have been shown to develop acromegaly. In 4 patients, clinical follow-up, and biological screening allowed to confidently exclude MEN1. Absence of mutation in the MEN1 gene after direct DNA analysis in 2 pedigrees reinforces the conviction that the families do not have MEN1. In families 1 and 2, diagnosis was made at a very early age and voluminous adenomas with suprasellar expansion were already present at the time of diagnosis. We review the 20 previous reports of familial acromegaly, some of them questionable. Our 3 families, combined with some other published pedigrees, allow the delineation of a familial form of acromegaly, distinct from MEN1. Dominant inheritance with reduced, age-dependant penetrance is the most parsimonious model to explain the recurrences. Gs protein pathway could be the site of action of the gene responsible of familial acromegaly, but no data have been published to sustain or reject this hypothesis. [less ▲]

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See detailElectrosynthesis of polyacrylic/polypyrrole composites : formation of polypyrrole wires
Jérôme, Christine ULg; Labaye, David; Bodart, Isabelle et al

in Synthetic Metals (1999), 101(1-3), 3-4

A new preparation method is reported for the synthesis of conducting polypyrrole nanowires. This two-step all-electrochemical method consists in the cathodic grafting of a thin polyacrylate film on a ... [more ▼]

A new preparation method is reported for the synthesis of conducting polypyrrole nanowires. This two-step all-electrochemical method consists in the cathodic grafting of a thin polyacrylate film on a carbon electrode, which is then used as an anode for the electropolymerization of pyrrole. Scanning electron microscopy shows the formation of polypyrrole wires (diameter ~600 nm lenght ~300 µm) growing through holes in the polyacrylate precoating. The effect of the experimental conditions, such as nature of the grafted polymer, solvent, and electrode, on the wire formation is discussed. [less ▲]

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See detailAnesthesie, analgesie et femme enceinte: une association a haut risque!
Brichant, Jean-François ULg; Incagnoli, P.

in Revue Médicale de Liège (1999), 54(5), 448-59

The authors review the changes in obstetric anesthesia and analgesia that have contributed to a decreased maternal mortality as well as those accounting for the clinically significant improvements of ... [more ▼]

The authors review the changes in obstetric anesthesia and analgesia that have contributed to a decreased maternal mortality as well as those accounting for the clinically significant improvements of maternal and neonatal morbidity. [less ▲]

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See detailHypertension et grossesse
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(5), 415-423

High blood pressure during pregnancy (BP > or = 140/90 mmHg) is sometimes already noted before conception, with usually a good prognosis (although it could predispose to preeclampsia). alpha-methyldopa is ... [more ▼]

High blood pressure during pregnancy (BP > or = 140/90 mmHg) is sometimes already noted before conception, with usually a good prognosis (although it could predispose to preeclampsia). alpha-methyldopa is the best treatment when needed (agents blocking the renin angiotensin system are not recommended). Preeclampsia, a form of hypertension noted after 20 weeks of gestation with proteinuria is a more serious condition (BP > or = 140/90 mmHg or increase in BP from the 1st trimester > or = 25/15 mmHg). It is generated by placental ischemia and creates maternal endothelial lesions which in turn decrease the blood flow to placenta leading to maternal and fetal syndromes. Hospitalisation is mandatory. No measure other than delivery is known to attenuate or reverse its progression. Treating hypertension during pregnancy (when blood pressure > or = 170/110 mmHg) aims at preventing maternal risk (stroke or eclampsia) but has few effect on foetal lesions. Prevention of this syndrome, which represents the first secondary cause of hypertension, is until now disappointing. [less ▲]

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See detailHELLP syndrome
Emonts, Patrick ULg; Thoumsin, H.; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (1999), 54(5), 444-7

The HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelet count) is a clinical expression of a multilayered disease whose central pathophysiology is abnormal placentation. Clinical research aims ... [more ▼]

The HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelet count) is a clinical expression of a multilayered disease whose central pathophysiology is abnormal placentation. Clinical research aims logically to search for new predictive and specific markers for the early identification of pregnant women at risk of developing a HELLP syndrome, the most common cause of feto-maternal mortality and morbidity. [less ▲]

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See detailLa PMA qui reussit Bilan d'activite du Centre de Procreation Medicalement assistee de l'ULg, 1985-1997
Dubois, Michel ULg; Jouan, Caroline ULg; Thonon, Fabienne ULg et al

in Revue Médicale de Liège (1999), 54(5), 387-92

Assisted reproductive treatments (ART) hold an increasing place in the field of female infertility but also of male infertility with the development of new micromanipulative technologies. From January ... [more ▼]

Assisted reproductive treatments (ART) hold an increasing place in the field of female infertility but also of male infertility with the development of new micromanipulative technologies. From January 1985 to December 1997, more than 3,000 ovarian punctures were achieved at the CPMA of the University of Liege and more than 40,000 oocytes were recovered. Global results show a take home baby rate of 23% per ovum pick-up and 27% per embryo transfer. Embryo cryopreservation offers an efficient solution to the problem of supernumerary embryos and opens the way for IVF-derived procedures such as oocyte or embryo donation, surrogate mother. The transfer of frozen-thawed embryos increases the total ongoing pregnancy rate per cycle of 31%. One of the aims of our Centre in the near future is the development of new technologies such as control of chromosomal abnormalities or genetic defect in preimplantation embryos and clinical applications of oocyte or ovarian tissue freezing. [less ▲]

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See detailLe streptocoque du groupe B, premiere cause d'infections neonatales graves. Epidemiologie et strategies de prevention
Melin, Pierrette ULg; Schmitz, M.; De Mol, Patrick ULg et al

in Revue Médicale de Liège (1999), 54(5), 460-7

As soon as the early 70's, group B streptococci (GBS) became clearly predominant in neonatal infections. There was a dramatic increase in the incidence of GBS neonatal sepsis and meningitis throughout ... [more ▼]

As soon as the early 70's, group B streptococci (GBS) became clearly predominant in neonatal infections. There was a dramatic increase in the incidence of GBS neonatal sepsis and meningitis throughout developed countries and GBS emerged as the leading cause of severe neonatal infections. Most of these infections, associated with high mortality and morbidity, could be prevented by intrapartum chemoprophylaxis given to risk mothers. AAP, ACOG and the CDC issued guidelines for their prevention. Today, in Belgium, there are still no recommendations for the prevention of GBS early-onset infections. [less ▲]

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See detailLa prevention de la prematurite en Communaute francaise a l'approche de l'an 2000
Nondonfaz, N.; Thoumsin, H.; Van Cauwenberge, Jean-Rémy ULg et al

in Revue Médicale de Liège (1999), 54(5), 440-3

The actual results confirm the dominating influence of psychosocial factors on prematurity and low birth weight. The study performed in Liege indicates that these factors must be taken into account for ... [more ▼]

The actual results confirm the dominating influence of psychosocial factors on prematurity and low birth weight. The study performed in Liege indicates that these factors must be taken into account for better care of the future mother. The systematic use of a prenatal questionnaire on psychosocial factors draws attention towards the personal situation of the future mother. Detection of some organic or psychosocial risk factors must prompt prophylactic measures even in the absence of any sign of pathologies. Prevention of prematurity has, over the last 30 years, been the primary objective of prenatal follow-up. Its importance must be further emphasized. [less ▲]

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See detailIn-Vitro Differences among Nonsteroidal Antiinflammatory Drugs in Their Activities Related to Osteoarthritis Pathophysiology
Henroitin, Y.; Reginster, Jean-Yves ULg

in Osteoarthritis and Cartilage (1999), 7(3), 355-7

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See detailComposition effect on the core-shell morphology and mechanical properties of ternary polystyrene/styrene-butadiene rubber/polyethylene blends
Luzinov, Igor; Xi, K.; Pagnoulle, Christophe et al

in Polymer (1999), 40(10), 2511-2520

The morphology of ternary polystyrene/styrene-butadiene rubber/polyethylene (PS/SBR/PE) blends has been investigated in the limits of a constant content of the major component (PS; 75 wt%) while changing ... [more ▼]

The morphology of ternary polystyrene/styrene-butadiene rubber/polyethylene (PS/SBR/PE) blends has been investigated in the limits of a constant content of the major component (PS; 75 wt%) while changing the weight ratio of the two minor constitutive polymers. A core-shell structure for the dispersed phase has been predicted from the spreading coefficients and observed by transmission electron microscopy. Actually, upon increasing the relative content of PE with respect to SBR, the structure of the dispersed phase changes from a multicore structure to a PE/SBR core-shell morphology. The size of the PE subphase in the mixed dispersed phase increases sharply at a PE content that corresponds to phase inversion in the parent SBR/PE binary blends. The ultimate mechanical properties of these blends are sensitive to the strength of the SBR interphase between PS and PE. Some synergism has been observed in the PE/SBR composition dependence of the tensile strengths at yield and break. [less ▲]

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See detailFranciel : un didacticiel pour l'auto-évaluation et l'auto-remédiation en français dans l'enseignement secondaire, I
Defays, Jean-Marc ULg; Saenen, Frédéric ULg; Renard, Denis

in Point sur la Recherche en Education (Le) (1999), 11

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See detailCalculation of Eddy Currents and Associated Losses in Electrical Steel Laminations
Gyselinck, Johan; Vandevelde, Lieven; Melkebeek, Jan et al

in IEEE Transactions on Magnetics (1999), 35(3), 1191-1194

Starting from the well known analytical formula for the eddy current losses in electrical steel laminations, saturation and edge effects are studied by means of 1D and 2D finite element models of a single ... [more ▼]

Starting from the well known analytical formula for the eddy current losses in electrical steel laminations, saturation and edge effects are studied by means of 1D and 2D finite element models of a single lamination. A novel method for directly including the laminated core energy dissipation in a time stepped 2D model of a complete (rotating) machine is proposed. By way of example the method is applied to a tooth model with enforced flux waveforms. [less ▲]

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See detailLes faces cachées du cancer du sein: modalites du suivi des hyperplasies et des cancers in situ
Lifrange, Eric ULg; Colin, Claude ULg

in Contraception, Fertilite, Sexualité (1992) (1999), 27(5), 364-7

After the diagnosis of breast epithelial hyperplasia or carcinoma in situ, the clinical follow-up must take into account several parameters. First, the adequacy of the diagnostic and the therapeutic ... [more ▼]

After the diagnosis of breast epithelial hyperplasia or carcinoma in situ, the clinical follow-up must take into account several parameters. First, the adequacy of the diagnostic and the therapeutic approach is to be evaluated. Second, the patient must be informed of her risk of subsequent breast cancer. In such a protocol, one can recommend a program of close follow-up in an attempt at early detection. An annual clinical examination combined with a mammographic and a sonographic exam is considered as the method of choice. In between annual check-ups, clinical exam is encouraged. The potential benefits of magnetic-resonance imaging in these circumstances is currently evaluated. In rare instances, the absolute risk of breast cancer is so high that a prophylactic mastectomy can be considered. [less ▲]

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See detailApproche algorithmique de la puberte precoce et tardive chez la fille
Bourguignon, Jean-Pierre ULg; LEBRETHON, Marie-Christine ULg

in Revue Médicale de Liège (1999), 54(5), 362-6

An algorithmic approach is proposed for the initial management of disorders of female puberty: premature pubarche and precocious or delayed breast development.

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See detailBronchial Eosinophilic Infiltration in Crohn's Disease in the Absence of Pulmonary Disease
Louis, Edouard ULg; Louis, Renaud ULg; Shute, J. et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (1999), 29(5), 660-6

BACKGROUND: Immunological and functional bronchopulmonary abnormalities may be present in up to two-thirds of patients with Crohn's disease. Having recently described a mild increase in methacholine ... [more ▼]

BACKGROUND: Immunological and functional bronchopulmonary abnormalities may be present in up to two-thirds of patients with Crohn's disease. Having recently described a mild increase in methacholine airways responsiveness in these patients, we investigated whether this physiological abnormality is associated with bronchial inflammation since it has previously been described in asthma. METHODS: Eighteen patients with Crohn's disease and 15 healthy controls matched for age, atopy and smoking habit, were studied. All the subjects underwent a bronchial methacholine challenge (1, 4 and 16 mg/mL) and a sputum induction by inhalation of hypertonic saline (NaCl 4.5%). The sputum samples were analysed for their cellular composition as well as for the levels of several mediators and proteins in the fluid phase, including eosinophil cationic protein (ECP), myeloperoxydase, albumin, alpha2-macroglobulin, interleukin-8 (IL-8), IgA and IL-8/immunoglobulin A complexes. RESULTS: When compared to control subjects, patients with Crohn's disease had significantly higher sputum eosinophil counts (14.5% [0-79.9%] vs 0.2% [0-2.3%]; P < 0. 001) and ECP levels (26.2 microg/L [4-124.2 microg/L] vs 9.8 microg/L [0-94.2 microg/L]; P < 0.05). However, patients with Crohn's disease had no sign of increased plasma exudation as reflected by sputum levels of albumin and alpha2-macroglobulin similar to those seen in control subjects. Furthermore the sputum levels of IL-8, IgA and IL-8/IgA complexes were not significantly different between the two groups. The magnitude of the fall in forced expiratory volume in 1 s after methacholine inhalation was significantly increased in Crohn's disease patients although it did not correlate with the extent of sputum eosinophilia or with the sputum ECP levels. CONCLUSIONS: Crohn's disease patients without any clinical respiratory involvement have airway eosinophilia without local increased plasma exudation. However, bronchial eosinophilia in Crohn's disease per se is not sufficient to induce clinically significant airway hyperresponsiveness, suggesting that other factors than bronchial eosinophilic infiltration are required for the clinical expression of an airway instability. [less ▲]

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See detailFinite Element Modelling with Transformation Techniques
Henrotte, François; Meys, Benoît; Hedia, Hakim et al

in IEEE Transactions on Magnetics (1999), 35(3), 1434-1437

Transformation methods are a very powerful tool in finite element modelling. In many cases, an adequate mapping transforms the problem into an easier one or allows advantage to be taken of the symmetries ... [more ▼]

Transformation methods are a very powerful tool in finite element modelling. In many cases, an adequate mapping transforms the problem into an easier one or allows advantage to be taken of the symmetries. This paper demonstrates that any mapping can be handled automatically provided the classical vector analysis approach is given up for the benefit of a differential geometry approach. As a first example, it is shown that axisymmetrical problems need no more a particular treatment provided the mapping of the cylindrical coordinates on the cartesian ones is considered as it is. Furthermore, a novel axisymmetrical formulation is proposed which relies on one further transformation and improves considerably the quality of the interpolated field. Transformation methods are also of great help to model the infinite space by means of finite elements. Many authors have presented such transformations which are often instances of the same general shell transformation that is presented here. [less ▲]

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See detailMise en oeuvre des anciennes ZEH : résistances administratives
Delnoy, Michel ULg

in Immobilier (1999), 8

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See detailChannel catfish virus gene 50 encodes a secreted, mucin-like glycoprotein
Vanderheijden, Nathalie; Hanson, Larry A.; Thiry, Etienne ULg et al

in Virology (1999), 257(1), 220-7

Cells infected with the wild-type (WT) strain of channel catfish virus (CCV) secreted a glycoprotein with an apparent molecular mass (MM) superior to 200 kDa into the culture medium. This protein ... [more ▼]

Cells infected with the wild-type (WT) strain of channel catfish virus (CCV) secreted a glycoprotein with an apparent molecular mass (MM) superior to 200 kDa into the culture medium. This protein, designated gp250, was the sole viral glycoprotein detected in the culture medium after [3H]mannose labeling of the infected cells. When cells were infected with the attenuated V60 strain, a glycoprotein of 135 kDa (designated gp135) was detected instead of gp250. Because WT gene 50 is predicted to encode a secreted, mucin-type glycoprotein, we expressed this gene transiently and detected a glycoprotein of the same apparent MM as gp250 in the culture medium of transfected catfish cells. The increased mobility in SDS-PAGE of the secreted V60 glycoprotein correlated with the presence of a major deletion in V60 gene 50. Therefore, we concluded that gp250 in the WT and gp135 in the V60 strains are both likely encoded by gene 50. An important shift in the relative mobility of gp250 in SDS-PAGE was observed after tunicamycin treatment of infected cells labeled with [3H]glucosamine, confirming the presence of N-linked sugars on gp250. We observed variations in the size of PCR products derived from gene 50 amplification in three different field isolates. Such genetic variations are a characteristic feature of mucin genes and are linked to crossing-over events between internal repeated sequences, such as those present in gene 50. [less ▲]

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See detailModulatory Effect of Imetit, a Histamine H3 Receptor Agonist, on C-Fibers, Cholinergic Fibers and Mast Cells in Rabbit Lungs in Vitro
Nemmar, A.; Delaunois, Annie ULg; Beckers, Jean-François ULg et al

in European Journal of Pharmacology (1999), 371(1), 23-30

The pharmacological mechanisms involved in the interactions between C-fibers, cholinergic fibers and mast cells were investigated in tracheally perfused rabbit lungs by measuring the simultaneous release ... [more ▼]

The pharmacological mechanisms involved in the interactions between C-fibers, cholinergic fibers and mast cells were investigated in tracheally perfused rabbit lungs by measuring the simultaneous release of substance P and histamine in lung effluents. The amounts of substance P and histamine released in lung superfusates were measured by radioimmunoassay (RIA) after administration of capsaicin and carbachol. Capsaicin (10(-4) M) induced a simultaneous increase in substance P (273 +/- 56% of baseline) and histamine (460 +/- 138%) release. Similarly, carbachol (10(-4) M) caused an increase in the release of both substance P (367 +/- 111%) and histamine (1379 +/- 351%). The effect of capsaicin was prevented by pretreating the lungs with the tachykinin NK1 receptor antagonist SR 140333 (10(-7) M), and atropine (10(-6) M). SR 140333 prevented the carbachol-induced release of substance P but not of histamine. Exogenous substance P induced an increase in histamine release (136 +/- 7%) which was significantly greater in lungs perfused with the neutral endopeptidase inhibitor, thiorphan (10(-5) M) (272 +/- 35%). This effect was prevented by atropine (10(-6) M). Pretreatment of lungs with imetit (5 x 10(-8) M), a selective H3 receptor agonist, prevented the capsaicin-induced release of both mediators. Imetit also blocked the carbachol-induced release of substance P but not of histamine. Exogenous substance P-evoked histamine release was inhibited by imetit. Therefore, it can be concluded that substance P released through the action of capsaicin can activate cholinergic fibers, leading to cholinoceptor stimulation with subsequent activation of C-fibers and mast cells. While the presence of presynaptic H3 receptors modulating substance P-induced acetylcholine release was only surmised, the existence of modulating histamine H3 receptors on C-fibers was confirmed. [less ▲]

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See detailRegulation of Nf-Kappab Activity by I Kappab-Related Proteins in Adenocarcinoma Cells
Dejardin, Emmanuel ULg; Deregowski, Valérie; Chapelier, Muriel et al

in Oncogene (1999), 18(16), 2567-77

Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High ... [more ▼]

Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High constitutive NF-kappaB activity and low I kappaB-alpha expression was found in a number of these cell lines. Moreover, some of these cells showed a high p100 expression, responsible for the cytoplasmic sequestration of most of p65 complexes. Treatment of these cells with TNF-alpha or other NF-kappaB activating agents induced only weakly nuclear NF-kappaB activity without significant p100 processing and led to a very weak transcription of NF-kappaB-dependent reporter gene. Induction of NF-kappaB activity can be restored by expression of the Tax protein or by treatment with antisense p100 oligonucleotides. In MCF7 A/Z cells stably transfected with a p100 expression vector, p65 complexes were sequestered in the cytoplasm by p100. These cells showed a reduced nuclear NF-kappaB induction and NF-kappaB-dependent gene transcription following TNF-alpha stimulation. As a consequence of a competition between I kappaB-alpha and p100, cells expressing high levels of p100 respond poorly to NF-kappaB activating stimuli as TNF-alpha. [less ▲]

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See detailHoxc5 and Hoxc8 Expression Are Selectively Turned on in Human Cervical Cancer Cells Compared to Normal Keratinocytes
Alami, Y.; Castronovo, Vincenzo ULg; Belotti, D. et al

in Biochemical and Biophysical Research Communications (1999), 257(3), 738-45

A growing number of data have sustained the involvement of homeobox genes expression deregulation in cancer. In this study, we have performed an exhaustive survey of the expression of the 39 class I HOX ... [more ▼]

A growing number of data have sustained the involvement of homeobox genes expression deregulation in cancer. In this study, we have performed an exhaustive survey of the expression of the 39 class I HOX genes expressed in normal and malignant human cervix keratinocytes. Using RT-PCR, we observed that the vast majority (34/39) of HOX genes are expressed in normal keratinocytes. Only HOXA2, HOXA7, HOXC5, HOXC8 and HOXD12 were found to be silent. Interestingly, this pattern is conserved in the transformed keratinocytes (SiHa cells) except for the appearance of HOXC5 and HOXC8 mRNA. The HOXC5 and HOXC8 expression was also observed in two other transformed keratinocytes cell lines of independent origins, Eil-8 and 18-11S3, and confirmed by in situ hybridization. Our data add weight to the body of evidence attributing to a specific adult tissue a particular combination of expressed HOX genes and suggest that HOXC5 and/or HOXC8 could be involved in the process leading to the transformation of cervical keratinocytes. [less ▲]

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See detailDynamics in miscible blends of polystyrene and poly(vinyl methyl ether)
Pathak, J. A.; Colby, R. H.; Floudas, G. et al

in Macromolecules (1999), 32(8), 2553-2561

We report results on the linear viscoelasticity (oscillatory shear in the temperature range Tg (glass-transition temperature) ≤ T ≤ Tg + 90 K) of miscible blends of polystyrene (PS) and poly(vinyl methyl ... [more ▼]

We report results on the linear viscoelasticity (oscillatory shear in the temperature range Tg (glass-transition temperature) ≤ T ≤ Tg + 90 K) of miscible blends of polystyrene (PS) and poly(vinyl methyl ether) (PVME) and segmental relaxations, measured by dielectric spectroscopy. The Flory−Huggins interaction parameter of this blend is weakly negative, and the glass transitions of the pure components are quite disparate (ΔTg = 125 K). PS/PVME blends have been found to be consistently thermorheologically complex at both the segmental and terminal levels: the empirical time−temperature superposition (tTS) principle applies to neither their oscillatory shear response nor their dielectric response. Using the tube model, we quantitatively compare dielectric and mechanical results. At low temperatures, the effective time scale for motion of a Kuhn segment (the shortest Rouse mode) is near the long-time end of the distribution of segmental relaxation times of PVME, in both the pure and blended states. The slowest relaxing segments thus control the longer-time relaxation processes of the chains. Miscible blends with weak interactions and large ΔTg have concentration fluctuations that broaden the distribution of segmental relaxation times. This distribution narrows as the temperature is raised in the blend, leading to the failure of tTS for terminal dynamics. [less ▲]

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See detailA Specific Pcr to Differentiate between Ge Negative Vaccine and Wildtype Bovine Herpesvirus Type 1 Strains
Schynts, F.; Baranowski, E.; Lemaire, Mylène et al

in Veterinary Microbiology (1999), 66(3), 187-95

In the context of infectious bovine rhinotracheitis (IBR) control programmes using glycoprotein E (gE) deleted marker vaccines, a PCR assay was developed to allow the genotypic differentiation between ... [more ▼]

In the context of infectious bovine rhinotracheitis (IBR) control programmes using glycoprotein E (gE) deleted marker vaccines, a PCR assay was developed to allow the genotypic differentiation between wildtype bovine herpesvirus type 1 (BoHV-1) and gE negative strains. This assay is based on the PCR amplification of a 281 bp DNA fragment within the gE gene. The specificity of the amplification was confirmed by restriction endonuclease analysis and nucleotide sequencing of the PCR product. Its ability to determine the gE genotype of BoHV-1 strains was demonstrated on isolates coming from 20 experimental calves infected with four different BoHV-1 strains. This PCR assay may be a useful tool for monitoring the spread of live marker vaccine and the gE genotype of viral field isolates. [less ▲]

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See detailMating-Induced Fos and Aromatase Are Not Co-Localized in the Preoptic Area
Foidart, Agnès ULg; Meddle, S. L.; Balthazart, Jacques ULg

in Neuroreport (1999), 10(5), 907-12

Male sexual behavior is determined by the interaction of endocrine and environmental stimuli originating from the female, yet it is unknown how and where these stimuli are integrated within the brain ... [more ▼]

Male sexual behavior is determined by the interaction of endocrine and environmental stimuli originating from the female, yet it is unknown how and where these stimuli are integrated within the brain. Activation of copulatory behavior by testosterone is limited by its central aromatization into an estrogen in the preoptic area. We investigated whether mating-induced neuronal activation as identified by the expression of the immediate early gene Fos occurs in aromatase-immunoreactive (ARO-ir) cells of the male quail preoptic area. Fos-immunoreactive (ir) cells were observed within and lateral to these ARO-ir cells groups but few ARO-ir cells contained Fos-ir indicating that mating-related stimuli do not directly affect estrogen-synthesizing cells. [less ▲]

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See detailThermodynamic Stability of a Cold-Active Alpha-Amylase from the Antarctic Bacterium Alteromonas Haloplanctis
Feller, Georges ULg; d'Amico, D.; Gerday, Charles ULg

in Biochemistry (1999), 38(14), 4613-9

The thermal stability of the cold-active alpha-amylase (AHA) secreted by the Antarctic bacterium Alteromonas haloplanctis has been investigated by intrinsic fluorescence, circular dichroism, and ... [more ▼]

The thermal stability of the cold-active alpha-amylase (AHA) secreted by the Antarctic bacterium Alteromonas haloplanctis has been investigated by intrinsic fluorescence, circular dichroism, and differential scanning calorimetry. It was found that this heat-labile enzyme is the largest known multidomain protein exhibiting a reversible two-state unfolding, as demonstrated by the recovery of DeltaHcal values after consecutive calorimetric transitions, a DeltaHcal/DeltaHeff ratio close to unity, and the independence of unfolding thermodynamic parameters of scan rates. By contrast, the mesophilic alpha-amylases investigated here (from porcine pancreas, human salivary glands, yellow meal beetle, Bacillus amyloliquefaciens, and Bacillus licheniformis) unfold irreversibly according to a non-two-state mechanism. Unlike mesophilic alpha-amylases, the melting point of AHA is independent of calcium and chloride binding while the allosteric and structural functions of these ions are conserved. The thermostability of AHA at optimal conditions is characterized by a Tm of 43.7 degrees C, a DeltaHcal of 238 kcal mol-1, and a DeltaCp of 8.47 kcal mol-1 K-1. These values were used to calculate the Gibbs free energy of unfolding over a wide range of temperatures. This stability curve shows that (a) the specific DeltaGmax of AHA [22 cal (mol of residue)-1] is 4 times lower than that of mesophilic alpha-amylases, (b) group hydration plays a crucial role in the enzyme flexibility at low temperatures, (c) the temperature of cold unfolding closely corresponds to the lower limit of bacterial growth, and (d) the recombinant heat-labile enzyme can be expressed in mesophilic hosts at moderate temperatures. It is also argued that the cold-active alpha-amylase has evolved toward the lowest possible conformational stability of its native state. [less ▲]

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See detailThe orientation within the Galaxy and the Large Magellanic Cloud of nebulae ejected by massive stars
Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1999), 344

The orientation of nebulae ejected by massive stars (Luminous Blue Variables, WR stars, SN1987A) is investigated with respect to the structure of the galaxy to which they belong. In the Galaxy, we find ... [more ▼]

The orientation of nebulae ejected by massive stars (Luminous Blue Variables, WR stars, SN1987A) is investigated with respect to the structure of the galaxy to which they belong. In the Galaxy, we find that the projected long axes of the nebulae most often align with the galactic plane, and then also with the galactic magnetic field. This alignment is statistically significant. In addition, a few nebulae are apparently oriented perpendicular to the galactic plane. In the Large Magellanic Cloud, the nebular axes are found to closely follow the spiral magnetic field. With different inclinations, the Galaxy and the Large Magellanic Cloud probably offer complementary views of the same phenomenon. Although the sample studied thus far is small and the statistics limited, these results suggest that the orientation of massive star ejecta depends on galactic magnetic fields. Since the nebular axes are apparently correlated to the symmetry axes of the stars themselves, and since, in the early evolutionary stages, alignments of accretion disk axes with the interstellar magnetic field have been reported, it is argued that the observed alignment effect results from the star formation process. Based in part on observations collected at the European Southern Observatory (ESO, La Silla) [less ▲]

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See detailModification of the polycarbonate/poly(vinylidene Fluoride) interface by poly(methyl methacrylate). Effect on the interfacial adhesion and interfacial tension
Moussaif, Noureddin; Jérôme, Robert ULg

in Macromolecular Symposia (1999), 139

Polycarbonate (PC) and poly(vinylidene fluoride) (PVDF) are two immiscible polymers which form two-phase blends with weak interfacial adhesion and high interfacial tension This situation may be changed by ... [more ▼]

Polycarbonate (PC) and poly(vinylidene fluoride) (PVDF) are two immiscible polymers which form two-phase blends with weak interfacial adhesion and high interfacial tension This situation may be changed by the addition of poly(methyl methacrylate) (PMMA), which concentrates preferably in the PVDF-rich phase, but also at the PVDF/PC interface. The interfacial activity of PMMA was estimated by the measurement of the interfacial adhesion and interfacial tension in relation to the PMMA content in the PVDF/PC blends. The interfacial adhesion between PC and homogeneous PVDF/PMMA blends of various compositions was measured by the dual cantilever beam technique The imbedded fiber retraction method was used for the measurement of the interfacial tension. A very beneficial effect was observed when PVDF was premixed with PMMA amounts increasing up to ca 35 wt-%., Beyond that content, the improvement tends to level off. [less ▲]

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See detailLa Gestion quotidienne des périodiques électroniques
Bawin, Marc-Henri ULg; Mottet, Philippe ULg

in Cahiers de la Documentation = Bladen voor Documentatie (1999), 53(1), 26-39

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See detailImpaired effective cortical connectivity in vegetative state : Preliminary investigation using PET
Laureys, Steven ULg; Goldman, Serge; Phillips, Christophe ULg et al

in Neuroimage (1999), 9(4), 377-382

Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awareness is part of consciousness, which itself is thought to represent an emergent property of cerebral neural ... [more ▼]

Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awareness is part of consciousness, which itself is thought to represent an emergent property of cerebral neural networks. Our hypothesis was that part of the neural correlate underlying VS is an altered connectivity, especially between the associative cortices. We assessed regional cerebral glucose metabolism (rCMRGlu) and effective cortical connectivity in four patients in VS by means of statistical parametric mapping and [F-18]fluorodeoxyglucose-positron emission tomography. Our data showed a common pattern of impaired rCMRGlu in the prefrontal, premotor, and parietotemporal association areas and posterior cingulate cortex/precuneus in VS. In a next step, we demonstrated that in VS patients various prefrontal and premotor areas have in common that they are less tightly connected with the posterior cingulate cortex than in normal controls. These results provide a strong argument for an alteration of cortical connectivity in VS patients. (C) 1999 Academic Press. [less ▲]

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See detailFemoral Anastomotic Aneurysms: Pathogenic Factors, Clinical Presentations and Treatment. A Study of 142 Cases
Demarche, Martine; Waltregny, David ULg; Van Damme, Hendrik ULg et al

in Cardiovascular Surgery (1999), 7(3), 315-22

In this study, the files of 112 patients with a total of 142 femoral anastomotic aneurysms were reviewed. Eighty-five patients (76%) were initially operated upon for obstructive aorto-iliac disease, while ... [more ▼]

In this study, the files of 112 patients with a total of 142 femoral anastomotic aneurysms were reviewed. Eighty-five patients (76%) were initially operated upon for obstructive aorto-iliac disease, while the remaining 27 (24%) had abdominal aortic aneurysms repaired. The majority of the patients (104/112) were male and their mean age was 64.5 years (range 45-88). Ninety-three per cent of the subjects were smokers prior to the first operation and 43% continued to smoke at the time of their femoral anastomotic aneurysms operation. The mean delay between the initial surgery and the repair of the femoral anastomotic aneurysms was 74.5 months (range 1-228). The diagnosis was made because of a painless pulsatile mass (91/142), acute leg ischaemia (27/142), a painful pulsatile mass (12/142), haemorrhage (10/142), pseudo-post-phlebitic oedema (1/142) and microemboli of the toes (1/142). The operative mortality was 2.7% (3/112) of which two-thirds were patients with infected grafts. Two subgroups were distinguished: 10 patients with an infected femoral anastomotic aneurysm and 12 patients with recurrent femoral anastomotic aneurysms, 11 with a single recurrence and one with a double recurrence. In the infected group, the time to development of anastomotic aneurysm was shorter than for the group with non-infected femoral anastomotic aneurysms (41 versus 74.5 months) and the operative mortality was 20% (2/10). One patient developed a recurrent femoral anastomotic aneurysm and another was lost to follow-up. Two subsequent deaths occurred, which were unrelated to the femoral anastomotic aneurysms. In the group of recurrent femoral anastomotic aneurysms one patient was lost to follow-up and two patients died, but not as a result of recurrent femoral anastomotic aneurysms. A total of 122 cases underwent interposition of a new prosthetic segment between the proximal prosthesis and the distal artery (89 at the common femoral, 21 at the femoral profundis, eight at the superficial femoral and four at an existing femoro-popliteal graft). [less ▲]

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See detail10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos Usambarensis
Frederich, Michel ULg; Tits, Monique ULg; Hayette, Marie-Pierre ULg et al

in Journal of Natural Products (1999), 62(4), 619-21

Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods ... [more ▼]

Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods. Compound 1 was moderately active against two strains of Plasmodium falciparum in vitro. [less ▲]

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See detailLeast Cost Optimum Design of Stiffened Hydraulic and Floating Structures
Rigo, Philippe ULg

in Bulletin de l’Association Internationale Permanente des Congrès de Navigation [Bulletin de l'AIPCN] (1999)

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See detailHommage en liberté et contraintes multiples
Durand, Pascal ULg

in Formules. Revue des littératures à contraintes (1999), 3

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See detailLe syndrome de tension prémenstruelle ou dysphorie prémenstruelle
Legros, S.; Foidart, Jean-Michel ULg; Gaspard, Ulysse ULg et al

in Revue Médicale de Liège (1999), 54(4), 268-73

Premenstrual Tension Syndrome (PMS) has always existed: it has been first described by an endocrinologist from New York in 1931. It is responsible for significant and psychological disorders which justify ... [more ▼]

Premenstrual Tension Syndrome (PMS) has always existed: it has been first described by an endocrinologist from New York in 1931. It is responsible for significant and psychological disorders which justify the study of its pathogenesis. Hormonal dysfunction has been demonstrated among women who are at risk for PMS; nevertheless, it has been shown that neurological transducers are also affected, such as GABAergic, serotoninergic and endorphinic systems. Interactions between the two systems allow to raise the hypothesis of an inbalance between GABAergic and progesterone derived neurosteroids in a psychoneuroendocrinological model. Based on this hypothesis, psychological symptoms can be efficiently treated by anxiolytic or antidepressant treatment. On the other hand, progesterone derivatives and, sometimes, diuretics, are useful on physical symptoms. As far as we know there is so far no single treatment of demonstrated efficacy in the PMS. [less ▲]

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See detailHyperandrogénie: sémiologie, exploration et traitement
Beckers, Albert ULg; Parotte, M. C.; Gaspard, Ulysse ULg et al

in Revue Médicale de Liège (1999), 54(4), 274-282

Androgen excess (AE) is one of the most common endocrine disorders, affecting 10% of adult women before the menopause. The clinical picture varies widely depending on the etiology of AE. Most of these ... [more ▼]

Androgen excess (AE) is one of the most common endocrine disorders, affecting 10% of adult women before the menopause. The clinical picture varies widely depending on the etiology of AE. Most of these women are suffering from hirsutism, acne, menstrual disturbances, anovulation and obesity. Virilization is unusual, except in patients with ovary or adrenal cancer. Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are the most frequent causes of androgen excess, accounting for more than 90% of the cases. The pathogenesis of PCOS is still an unresolved problem. A hereditary predisposition has been suggested. Enzymatic deficiency is a less frequent cause of AE, the most common deficiency being the non classic 21-OH deficiency (NCAH). AE has been implicated as a side effect of many drugs. Ovary and adrenal tumours are unusual, however, they must be considered especially in case of severe hirsutism or virilization. Complementary investigations are selected based on the result of clinical examination. Pharmacologic therapy, usually with anti-androgens, is the most widely used treatment for PCOS, IH and NCAH. Surgical therapy should be considered only when there is a particular indication such as Cushing's syndrome, ovary or adrenal tumours. [less ▲]

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See detailComment évaluer la sévérité d'un RGO et quels sont les objectifs thérapeutiques?
Louis, Edouard ULg; Marquis, P.; Nalet, B.

in Revue Médicale de Bruxelles (1999), 20(2), 114-5

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See detailLe condylome
Kridelka, Frédéric ULg

in Revue Médicale de Liège (1999), 54(4), 283-8

HPV related pathologies are the commonest reasons for consulting a gynaecologist. Genital warts are associated with infection by HPV type 6 or 11. Etiopathogenetic factors and treatment modalities are ... [more ▼]

HPV related pathologies are the commonest reasons for consulting a gynaecologist. Genital warts are associated with infection by HPV type 6 or 11. Etiopathogenetic factors and treatment modalities are reviewed. [less ▲]

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See detailTransmission line torsional stiffness. Confrontation of field-tests line and finite element simulations.
keutgen, Renaud; Lilien, Jean-Louis ULg; Yukino, Teruhiro

in IEEE Transactions on Power Delivery (1999), 14(N°2), 567-578

Bundle torsional stiffness, Full scale field tests on a quad bundle compared to a finite element stiffness and simplified model.

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See detailFaut-il instaurer un traitement en prévention primaire chez la femme hypercholestérolémique?
Paquot, Nicolas ULg

in Revue Médicale de Liège (1999), 54(4), 240-3

Limited data are available in women from randomized trials of lipid-lowering therapy for primary prevention of coronary heart disease (CHD). In women with isolate hypercholesterolemia but no clinical ... [more ▼]

Limited data are available in women from randomized trials of lipid-lowering therapy for primary prevention of coronary heart disease (CHD). In women with isolate hypercholesterolemia but no clinical symptoms of CHD and no other risk factors, there is no evidence that lipid-lowering therapy is of benefit. In postmenopausal women with hypercholesterolemia and other risk factors (particularly diabetes and family history of CHD), lipid-lowering therapy may be of benefit. In those women, hormone replacement therapy may be proposed in the treatment of postmenopausal hypercholesterolemia. [less ▲]

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See detailLa femme et les maladies cardio-vasculaires, en particulier, les coronaropathies
Kulbertus, Henri ULg; Legrand, Victor ULg

in Revue Médicale de Liège (1999), 54(4), 244-50

Cardiovascular diseases represent the major cause of death in women. If women are early in life relatively protected by their hormones, after the menopause heart disease and stroke become their greatest ... [more ▼]

Cardiovascular diseases represent the major cause of death in women. If women are early in life relatively protected by their hormones, after the menopause heart disease and stroke become their greatest health threat. Altogether one in three women will die of cardiovascular disease whereas only one in twenty-two will die of breast cancer. The risk factors for cardiovascular diseases are similar in both sexes. It should be noted however that the impact of diabetes on the development of coronary artery disease is markedly higher in woman than in man. In woman the first presenting symptom of coronary artery disease frequently is angina pectoris. In man it is more often an acute myocardial infarction whether it be symptomatic or silent. The various non invasive techniques used for the diagnosis of coronary artery disease may yield results that pose very difficult problems of differential diagnosis in women. Several studies indicate that in the past, probably because of the ignorance by the public and, perhaps, the medical profession of the high prevalence of cardiovascular and coronary artery diseases in women, the latter have not always received an optimal treatment when they suffered an acute ischemic attack. But, in this decade, they have been dramatic changes in the patents of clinical practice related to coronary heart disease in women. Statistical investigations however indicate that thrombolytic therapy appears less efficacious in women than in men whereas beta-blockers administered early in acute MI are of remarkable efficacy in women. It seems generally agreed that the results of revascularization by coronary artery bypass surgery are poorer in women than in men both in terms of operative mortality and morbidity. Initially, the same pessimism was reported for PTCA. However, recent results allow a much more optimistic view. [less ▲]

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