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See detailNéron et la magie
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (2003), 62

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See detailRENO, a European Postmarket Surveillance Registry, confirms effectiveness of coronary brachytheraypy in routine clinical practice.
Coen, V; Serruys, P; Sauerwein, W et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 55(4), 1019-1026

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or ... [more ▼]

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or bypass grafts) treated with -radiation. Methods and Materials: Between April 1999 and September 2000, 1098 consecutive patients treated in 46 centers in Europe and the Middle East with the Novoste Beta-Cath System were included in Registry Novoste (RENO). Results: Six-month follow-up data were obtained for 1085 patients. Of 1174 target lesions, 94.1% were located in native vessels and 5.9% in a bypass graft; 17.7% were de novo lesions, 4.1% were restenotic, and 77.7% were in-stent restenotic lesions. Intravascular brachytherapy was technically successful in 95.9% of lesions. Multisegmental irradiation, using a manual pullback stepping maneuver to treat longer lesions, was used in 16.3% of the procedures. The in-hospital rate of major adverse cardiac events was 1.8%. At 6 months, the rate was 18.7%. Angiographic follow-up was available for 70.4% of the patients. Nonocclusive restenosis was seen in 18.8% and total occlusion in 5.7% of patients. A combined end point for late (30–180 days) definitive or suspected target vessel closure was reached in 5.4%, but with only 2% of clinical events. Multivariate analysis was performed for major adverse cardiac events and late thrombosis. Conclusion: Data obtained from the multicenter RENO registry study, derived from a large cohort of unselected consecutive patients, suggest that the good results of recent randomized controlled clinical trials can be replicated in routine clinical practice. © 2003 Elsevier Science Inc. [less ▲]

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See detailExpression In A Rabgap Yeast Mutant Of Two Human Homologues, One Of Which Is An Oncogene
Bizimungu, C.; De Neve, N.; Burny, A. et al

in Biochemical and Biophysical Research Communications (2003), 310(2),

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See detailNon-adiabatic effects in photodissociation of bromoacetyl chloride
Bacchus-Montabonel, Marie-Christine; Vaeck, Nathalie; Lasorne, Benjamin et al

in Chemical Physics Letters (2003), 374

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See detailRegulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Mottet, Denis ULg; Dumont, Valery; Deccache, Yann et al

in Journal of Biological Chemistry (2003), 278(33), 31277-85

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms ... [more ▼]

Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 activity is regulated through different mechanisms involving stabilization of HIF-1alpha, phosphorylations, modifications of redox conditions, and interactions with coactivators. However, it appears that some of these steps can be cell type-specific. Among them, the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in the regulation of HIF-1 by hypoxia remains controversial. Here, we investigated the activation state of PI3K/Akt/glycogen synthase kinase 3beta (GSK3beta) in HepG2 cells. Increasing incubation times in hypoxia dramatically decreased both the phosphorylation of Akt and the inhibiting phosphorylation of GSK3beta. The PI3K/Akt pathway was necessary for HIF-1alpha stabilization early during hypoxia. Indeed, its inhibition was sufficient to decrease HIF-1alpha protein level after 5-h incubation in hypoxia. However, longer exposure (16 h) in hypoxia resulted in a decreased HIF-1alpha protein level compared with early exposure (5 h). At that time, Akt was no longer present or active, which resulted in a decrease in the inhibiting phosphorylation of GSK3beta on Ser-9 and hence in an increased GSK3beta activity. GSK3 inhibition reverted the effect of prolonged hypoxia on HIF-1alpha protein level; more stabilized HIF-1alpha was observed as well as increased HIF-1 transcriptional activity. Thus, a prolonged hypoxia activates GSK3beta, which results in decreased HIF-1alpha accumulation. In conclusion, hypoxia induced a biphasic effect on HIF-1alpha stabilization with accumulation in early hypoxia, which depends on an active PI3K/Akt pathway and an inactive GSK3beta, whereas prolonged hypoxia results in the inactivation of Akt and activation of GSK3beta, which then down-regulates the HIF-1 activity through down-regulation of HIF-1alpha accumulation. [less ▲]

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See detail1s2s2p(2)3s 6P - 1s2p(3)3s 6S° transitions in OIV
Lin, B.; Berry, H. G.; Shibata, T. et al

in Physical Review. A (2003), 67

The energies and lifetimes of doubly excited sextet states of boron-like O IV, F V, and Ne VI are calculated with the multiconfiguration Hartree-Fock approach, including QED and higher-order corrections ... [more ▼]

The energies and lifetimes of doubly excited sextet states of boron-like O IV, F V, and Ne VI are calculated with the multiconfiguration Hartree-Fock approach, including QED and higher-order corrections, and also with the multiconfiguration Dirac-Fock GRASP code. The wavelengths and transition rates of electric-dipole transitions from the inner-shell excited terms 1s2s2p23s 6P–1s2p33s 6So are investigated by beam-foil spectroscopy in the XUV spectral region. The predicted transition wavelengths agree with the experiment. The higherorder corrections, fine structures, and spectrum with high wavelength resolution are found to be critically important in these comparisons. Nine new lines have been identified. The ground sextet states of boronlike atoms are metastable and well above several ionization levels. These are possible candidates for XUV and soft x-ray lasers. [less ▲]

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See detailAlzheimer' Disease as a Disconnection Syndrome?
Delbeuck, Xavier; Van der Linden, Martial ULg; Collette, Fabienne ULg

in Neuropsychology Review (2003), 13(2), 79-92

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See detailLes échecs électifs en mathématique : un regard inspiré de la didactique.
Schneider, Marguerite ULg

in Mathématique et Pédagogie (2003), 140

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See detailL'éloge de la folie en hôpital de jour: présent du passé et perspectives
Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2003)

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See detailApplication of a damage model to an aluminium alloy
Castagne, Sylvie; Habraken, Anne ULg; Cescotto, Serge ULg

in International Journal of Damage Mechanics (2003), 12(1), 5-30

An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the ... [more ▼]

An energy-based isotropic elastoplastic model coupled to damage is implemented in the finite element code LAGAMINE developed for more than fifteen years in the MSM department. In this model, based on the local approach of ductile fracture, effective stresses associated to damage variables are introduced. The damage law allows a continuous description of crack appearance. After a brief description of the model, its identification and its validation for an aluminum alloy are presented. Finally, the research of a global rupture criterion associated to this model is introduced. [less ▲]

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See detailAn X-ray Rietveld, infrared, and Mossbauer spectral study of the NaMn(Fe1-xInx)(2)(PO4)(3) alluaudite-type solid solution
Hatert, Frédéric ULg; Hermann, Raphaël ULg; Long, Gary J. et al

in American Mineralogist (2003), 88(1), 211-222

Several compounds of the NaMn(Fe1-xInx)(2)(PO4)(3) solid solution were synthesized by solid state reaction in air; pure alluaudite-like compounds were obtained for x = 0.00 to 1.00. X-ray Rietveld ... [more ▼]

Several compounds of the NaMn(Fe1-xInx)(2)(PO4)(3) solid solution were synthesized by solid state reaction in air; pure alluaudite-like compounds were obtained for x = 0.00 to 1.00. X-ray Rietveld refinements indicate the presence of Na+ at the A1 and A2' sites, Mn2+ at the M1 site, and Fe2+, Fe3+, and In3+ at the M2 site. The presence of small amounts of In3+ at the M I site, and Mn2+ at the M2 site, indicates a partially disordered distribution between these cations. A good correlation was also established between the M1-M2 bond distance and the beta angle of the alluaudite-like compounds. The disordered distribution of Fe2+, Fe3+, and In3+ at the M2 site is confirmed by the broadness of the infrared absorption bands. The Mossbauer spectra, measured between 90 and 295 K, were analyzed in terms of a model that takes into account the next-nearest neighbor interactions around the M2 crystallographic site. In all cases these spectra reveal the unexpected presence of small amounts of Fe2+ at the M2 site, an amount that decreases as the In3+ content increases. The Fe2+ and Fe3+ isomer shifts are typical of the alluaudite structure and vary with temperature, as expected from a second-order Doppler shift. The derived iron vibrating masses and Mossbauer lattice temperatures are within the expected range of values for iron cations in an octahedral environment. The Fe2+ and Fe3+ quadrupole splittings are also typical of the alluaudite structure and the temperature dependence of the Fe2+ quadrupole splitting was fit with the model of Ingalls (1964), which yielded a ground state orbital splitting of ca. 380 to 570 cm(-1) for the Fe2+ sites. [less ▲]

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See detailUse of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses.
Van Erck, Emmanuelle ULg; Votion, Dominique ULg; Kirschvink, Nathalie et al

in American Journal of Veterinary Research (2003), 64(11), 1414-1420

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses ... [more ▼]

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses. ANIMALS: 10 horses (4 healthy; 6 with recurrent airway obstruction [heaves] in remission). PROCEDURE: Healthy horses (group-A horses) and heaves-affected horses (group-B horses) were housed in a controlled environment. At each step of a methacholine bronchoprovocation test, threshold concentration (TC(2SD); results in a 2-fold increase in SD of a value) and sensitivity index (SI) were determined for respiratory tract system resistance (R(rs)) and respiratory tract system reactance (X(rs)) at 5 to 20 Hz by use of IOS and for total pulmonary resistance (RL) and dynamic lung compliance (C(dyn)), by use of CRT. RESULTS: Bronchoconstriction resulted in an increase in R(rs) at 5 Hz (R(5Hz)) and a decrease in X(rs) at all frequencies. Most sensitive parameters were X(rs) at 5 Hz (X(5Hz)), R(5Hz), and R(5Hz):R(10Hz) ratio; RL and the provocation concentration of methacholine resulting in a 35% decrease in dynamic compliance (PC(35)C(dyn)) were significantly less sensitive than these IOS parameters. The TC(2SD) for X(rs) at 5 and 10 Hz was significantly lower in group-B horses, compared with group-A horses. The lowest TC(2SD) was obtained for X(5Hz) in group-B horses and R(5Hz) in group-A horses. CONCLUSIONS AND CLINICAL RELEVANCE: In contrast to CRT parameters, IOS parameters were significantly more sensitive for testing pulmonary function.The IOS provides a practical and noninvasive pulmonary function test that may be useful in assessing subclinical changes in horses. [less ▲]

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See detailRuthenium catalysts bearing N-heterocyclic carbene ligands in atom transfer radical reactions
Richel, Aurore ULg; Delfosse, Sébastien ULg; Cremasco, Cédric et al

in Tetrahedron Letters (2003), 44(32), 6011-6015

The catalytic activity of ruthenium-p-cymene complexes bearing N-heterocyclic carbene ligands in atom transfer radical addition (ATRA) or polymerisation (ATRP) strongly depends on the substituents of the ... [more ▼]

The catalytic activity of ruthenium-p-cymene complexes bearing N-heterocyclic carbene ligands in atom transfer radical addition (ATRA) or polymerisation (ATRP) strongly depends on the substituents of the carbene ligand, thereby providing a nice illustration of the importance of organometallic engineering and ligand fine tuning in homogeneous catalysis. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMathematical modelling and design of an advanced once-through heat recovery steam generator
Dumont, Marie-Noëlle ULg; Heyen, Georges ULg

in Computer Aided Chemical Engineering (2003), 14

The once-through heat recovery steam generator design is ideally matched to very high temperature and pressure, well into the supercritical range. Moreover this type of previous termboilernext term is ... [more ▼]

The once-through heat recovery steam generator design is ideally matched to very high temperature and pressure, well into the supercritical range. Moreover this type of previous termboilernext term is structurally simpler than a conventional one, since no drum is required. A specific mathematical model has been developed. Thermodynamic model has been implemented to suit very high pressure (up to 240 bar), sub- and supercritical steam properties. We illustrate the model use with a 180 bar once-through previous termboilernext term (OTB). [less ▲]

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See detailIdentification On Commercialized Products Of Aflp Markers Able To Discriminate Slow- From Fast-Growing Chicken Strains
Fumiere, Olivier; Dubois, Marc; Gregoire, Dimitrie et al

in Journal of Agricultural and Food Chemistry (2003), 51(5), 1115-1119

The European chicken meat market is characterized by numerous quality marks: “Label de Qualité Wallon” in Belgium, “Label Rouge” in France, denominations of geographical origin, organic agriculture, etc ... [more ▼]

The European chicken meat market is characterized by numerous quality marks: “Label de Qualité Wallon” in Belgium, “Label Rouge” in France, denominations of geographical origin, organic agriculture, etc. Most of those certified productions have specifications requiring the use of slow-growing chicken strains. The amplified fragment length polymorphism (AFLP) technique has been used to search molecular markers able to discriminate slow-growing chicken strains from fast-growing ones and to authenticate certified products. Two pairs of restriction enzymes (EcoRI/MseI and EcoRI/TaqI) and 121 selective primer combinations were tested on individual DNA samples from chicken products essentially in carcass form that were ascribed as belonging to either slow- or fast-growing strains. Within the resulting fingerprints, two fragments were identified as type−strains specific markers. One primer combination gives a band (333 bp) that is specific for slow-growing chickens, and another primer pair generates a band (372 bp) that was found to be characteristic of fast-growing chickens. The two markers were isolated, cloned, and sequenced. The effectiveness and the specificity of the two interesting determinants were assessed on individuals of two well-known strains (ISA 657 and Cobb 500) and on commercialized products coming from various origins. [less ▲]

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See detailFlow cytometric cerebrospinal fluid analysis in children
Häusler, M.; Sellhaus, B.; Schweizer, K. et al

in Pathology Research and Practice (2003), 199(10), 667-675

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume ... [more ▼]

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume, surface antigen expression) even in small amounts of cells. Data on CSF FC in children are very limited. Here, we summarize our 3-year experience of CSF FC routinely performed in pediatric patients with assumed inflammatory central nervous system (CNS) disease. Among 109 samples sent for analysis, flow cytometric detection of major leukocyte subsets was possible in 78% (85 out of 109), which exceeds the 31% rate of our retrospective microscopic pediatric control group. Apart from physiologic lymphocytes (100%) or monocytes (48%), 11 out of these 85 samples showed granulocytes, two showed proliferated monocytes, and nine displayed proliferated lymphocytes. In most children, the proliferated lymphocytes consisted of a polyclonal population of CD4+ and CD8+ T cells. Compared with literature data, eight children showed abnormally composed lymphocyte subsets (surface antigen expression) within the main lymphocyte population. However, none of these changes was specific for distinct diseases or allowed a distinction between patients with and without primary inflammatory processes. These data suggest that CSF FC may be the most effective modality to differentiate major CSF leukocyte subsets. At present, further differentiation of distinct cell populations, such as proliferated lymphocytes, is of limited clinical impact. This may, however, gain increasing interest in the future. [less ▲]

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See detailPrevention de la nephropathie diabetique: de la microalbuminurie a l'insuffisance renale terminale.
Weekers, Laurent ULg; Scheen, André ULg; Rorive, Georges ULg

in Revue Médicale de Liège (2003), 58(5), 297-306

Diabetic nephropathy is one of the leading causes of end-stage renal failure in western countries. This disease develops over several years. Early stages, if they are detected in time, can lead to ... [more ▼]

Diabetic nephropathy is one of the leading causes of end-stage renal failure in western countries. This disease develops over several years. Early stages, if they are detected in time, can lead to preventive treatment at a moment when the disease is still reversible. This paper reviews the main primary and secondary preventive measures that have been proven efficacious. Those are essentially the optimal treatment of hyperglycaemia and hypertension, and probably the use of agents that specifically block the renin-angiotensin axis. We briefly discuss the results of the main studies that have led to those conclusions. [less ▲]

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See detailThe impact of reimbursement criteria on the appropriateness of 'statin' prescribing.
Autier, Philippe; Creplet, Jean; Vansant, Greet et al

in European Journal of Cardiovascular Prevention & Rehabilitation (2003), 10(6), 456-62

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated ... [more ▼]

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated the possible impact of these regulations on characteristics of Belgian patients receiving a lipid-lowering drug. DESIGN: From 1998 to 2000, standard questionnaires on coronary risk factors and treatments with lipid-lowering drugs were completed by 301 GPs sampled at random in the 11 Belgian Provinces. Questionnaires had to be completed for 18 consecutive patients 35 years old or more attending GPs' practices, irrespective of the underlying motive for attendance. RESULTS: Of the 5511 patients included in the study, 1519 (28%) had established coronary disease or diabetes mellitus, or > or = 2 non-cholesterol coronary risk factors. Most (70%) of these patients were not treated with a lipid-lowering drug. Only 22% of patients with established coronary disease, 10% of patients with diabetes mellitus and 9% of patients with > or = 2 coronary risk factors were treated with a statin. Fifty-nine percent of fibrate users and 50% of statin users had a pre-treatment cholesterol level above 250 mg/dl, but had no or only one non-cholesterol coronary risk factor. CONCLUSIONS: In Belgium, the majority of patients at higher risk of coronary event do not benefit from lipid-lowering drugs, particularly the statins. In contrast, one of two statin users and three of five fibrate users should probably not receive the drug prescribed. Regulation based on blood cholesterol level encourages the overlooking of other risk factors relevant for selecting patients having the greatest chance to benefit from statin treatment. [less ▲]

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See detailMinitransplants: allogeneic stem cell transplantation with reduced toxicity.
Beguin, Yves ULg; Baron, Frédéric ULg

in Acta Clinica Belgica (2003), 58(1), 37-45

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the conditioning regimen and the graft-versus-host reactions, respectively. The high-dose chemo-radiotherapy conditioning regimen is aimed at destroying tumor cells, ablating the host immune system (to prevent rejection) and eliminating the host bone marrow (to "make space" for donor stem cells). However, the definitive eradication of tumor cells is also largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger (< 55 years) and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols based on a two step approach: first the use of immunosuppressive (but nonmyeloablative) conditioning regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. These transplants are called nonmyeloablative HSCT or reduced-conditioning HSCT or minitransplants. Preliminary results show that minitransplants are feasible with a relatively low transplant-related mortality (TRM) even in patients up to 70 years. In addition, strong anti-tumor responses are observed in several hematological malignancies as well as in some patients with renal cell carcinoma. As the benefits of minitransplants over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

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See detailJansénisme et monachisme féminin aux pays de Liège et de Luxembourg
Henneau, Marie-Elisabeth ULg

in Chroniques de Port-Royal (2003), 52

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See detailCreolization in Robert Antoni's Blessed Is the Fruit: A Linguistic Analysis
Ledent, Bénédicte ULg

in Matatu : Journal for African Culture and Society (2003), 27-28

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See detailRooting blockage in the tobacco rac mutant occurs at the initiation phase, and induces diversion to xylem differentiation
Faivre-Rampant, Odile; D'Angeli, S.; Falasca, G. et al

in Plant Biosystems (2003), 137(2), 163-174

The rac mutant of Nicotiana tabacum L. cv. Xanthii is impaired in adventitious root formation. The objective of the present study was to determine whether or not the root induction phase occurs in the rac ... [more ▼]

The rac mutant of Nicotiana tabacum L. cv. Xanthii is impaired in adventitious root formation. The objective of the present study was to determine whether or not the root induction phase occurs in the rac mutant, and if so, to determine what causes the induced cells to become incapable of organising root primordia. To this end, rac and wild-type shoots were cultured in vitro for 7 days under conditions suitable for obtaining roots in the wild-type (i.e., exposure to 5 muM indole-3-butyric acid for 4 h, and then transfer to hormone-free medium), and then histologically and biochemically analysed during culture. The variations in peroxidase activity, and in cellular levels of auxins and polyamines revealed that the induction phase occurs in rac shoots, although it lasts longer than in the wild-type ones. Furthermore, both auxin and polyamines were consistently higher in rac shoots compared to the wild-type. After induction, auxin and putrescine levels abruptly decreased in the wild-type shoots, whereas they decreased much more slowly in the rac mutant. The histological analysis of the wild-type shoots showed that the abrupt decrease in auxin and polyamine levels were correlated with a normal initiation phase. In fact, wild-type shoots showed cell divisions in the procambium already at day 2, resulting in the formation of root primordia at day 4, and in root emergence between days 5 and 7. In rac shoots, despite the fact that the procambium cells were activated to undergo cell division, the initiation phase was highly perturbed, and the procambial cells developed tracheary elements instead of adventitious roots. The different morphogenic responses of the two genotypes are discussed in the light of the differences in auxin content after the induction phase. [less ▲]

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See detailThe Acyclic Nucleoside Phosphonate Analogues, Adefovir, Tenofovir And Pmedap, Efficiently Eliminate Banana Streak Virus From Banana (Musa Spp.)
Helliot, B.; Panis, B.; Frison, E. et al

in Antiviral Research (2003), 59(2), 121-126

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See detailAstronomes célèbres et astronomes moins connus ... (1) William Herschel
Biémont, Emile ULg

in Galactée (2003), 34

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See detailCensure et stéréotype. Structures du sens commun journalistique
Durand, Pascal ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2003), 97-99

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See detailAstronomes célèbres et astronomes moins connus ... (3) Hipparque
Biémont, Emile ULg

in Galactée (2003), 35

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See detailAlong or across front ocean survey strategy? The estimation of quasi-geostrophic vertical velocities and temperature fluxes
Rixen, Michel; Allen, J. T.; Pollard, R. T. et al

in Geophysical Research Letters (2003), 30(5), 61-68

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio ... [more ▼]

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio-chemical properties when the front is sufficiently developed. The cruise design based on the optimal reconstruction of the density fields does however not imply that derived variables like quasi-geostrophic (QG) vertical velocities and temperature fluxes also exhibit minimal associated errors. Here we present results of optimized sampling strategies for diagnostic QG vertical velocities (wQG) and temperature fluxes (θQG) derived from the omega equation. Results are illustrated in the same framework, for the Iceland-Faroes oceanic frontal area and for a control model and reveal that at these spatio-temporal scales, the unusual AL may also provide better estimations of vertical velocities and temperature fluxes compared to the classic AC, especially when the front is sufficiently developed. [less ▲]

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See detailAstronomes célèbres et astronomes moins connus ... (2) Les Cassini
Biémont, Emile ULg

in Galactée (2003), 35

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See detailNitric oxide and cardiac function: ten years after, and continuing.
MASSION, Paul ULg; Feron, O.; Dessy, C. et al

in Circulation Research (2003), 93(5), 388-98

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The former include regulation ... [more ▼]

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The former include regulation of coronary vessel tone, thrombogenicity, and proliferative and inflammatory properties as well as cellular cross-talk supporting angiogenesis. The latter comprise the direct effects of NO on several aspects of cardiomyocyte contractility, from the fine regulation of excitation-contraction coupling to modulation of (presynaptic and postsynaptic) autonomic signaling and mitochondrial respiration. This multifaceted involvement of NO in cardiac physiology is supported by a tight molecular regulation of the three NO synthases, from cellular spatial confinement to posttranslational allosteric modulation by specific interacting proteins, acting in concert to restrict the influence of NO to a particular intracellular target in a stimulus-specific manner. Loss of this specificity, such as produced on excessive NO delivery from inflammatory cells (or cytokine-stimulated cardiomyocytes themselves), may result in profound cellular disturbances leading to heart failure. Future therapeutic manipulations of cardiac NO synthesis will necessarily draw on additional characterization of the cellular and molecular determinants for the net effect of this versatile radical on the cardiomyocyte biology. [less ▲]

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See detailNéoplasie endocrinienne multiple de type 1 : De la clinique au gène
Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg; Vanbellinghen, Jean-François ULg et al

in Feuillets de Biologie (2003), 44(250), 39-48

La Néoplasie Endocrinienne Multiple de type 1 (NEM 1), syndrome génétique à transmission autosomique dominante, est caractérisée principalement par l'atteinte des parathyroïdes, du tractus gastro-entéro ... [more ▼]

La Néoplasie Endocrinienne Multiple de type 1 (NEM 1), syndrome génétique à transmission autosomique dominante, est caractérisée principalement par l'atteinte des parathyroïdes, du tractus gastro-entéro-pancréatique et de l'antéhypophyse. Les manifestations cliniques de ce syndrome sont polymorphes. En fonction de l'organe affecté elles peuvent se manifester par l'hypersécrétion hormonale, par un syndrome de masse dû à la taille tumorale, ou parfois par l'apparition d'un cancer. Le gène responsable de la NEM 1 a été identifié sur le chromosome 11, locus 11q13. Il s'agit d'un gène supresseur de tumeur qui code pour une protéine dénommée ménine. Dans cet article nous aborderons les aspects cliniques et génétiques typiques de cette affection. [less ▲]

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See detailPropriétés des merrains affinés dans une solution d’enzymes naturels et destinés à la tonnellerie
Jourez, Benoît ULg; Charron, Stéphane; Hebert, Jacques ULg

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60

Properties of shooks ageing by a treatment in a solution of natural enzymes. A speeding up of the ageing of shooks is possible by a treatment with a solution of natural enzymes. However its repercussion ... [more ▼]

Properties of shooks ageing by a treatment in a solution of natural enzymes. A speeding up of the ageing of shooks is possible by a treatment with a solution of natural enzymes. However its repercussion on physical, mechanical characteristics of wood and on its absorption potential of an hydro-alcoholic solution must be tested. Normalized samples have been extracted from 150 shooks selected on a ring width criteria from three cooperages located on different supplying area in France. The three factors cooperage, ring width class and treatment are used for statistical analysis. The cooperage factor, reflection of the supply area of each of them, affect the young modulus and the modulus of rupture in static bending but not the other characteristics. The improvement of the wood properties is closely linked to the ring width increaseof the samples. The enzymatic treatment has no significant effect on physical and mechanical characteristics of oak wood, except on the hardness and, to a lesser extent, on the absorption potential. Considering the absence of negative effect on characteristics of shooks and the positive contribution of enzymatic treatment on their ageing, this treatment could bring a very interesting economical alternative permitting to avoid long lasting storage of the shooks before assembly. [less ▲]

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See detailAllons-nous mourir bronzés ou ostéomalaciques? Le dilemme de la protection solaire entre Charybde et Scylla
Uhoda, I.; Crestey, M.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2003), 58(5), 307-9

Sun is at the origin of life. It can also be responsible for death. In the past decades cutaneous melanoma killed more and more young adults. Currently, the disease still progresses in the population, but ... [more ▼]

Sun is at the origin of life. It can also be responsible for death. In the past decades cutaneous melanoma killed more and more young adults. Currently, the disease still progresses in the population, but survival increases hopefully. Sun is pointed out as the main culprit. Hence, protection against harmful effects of ultraviolets is mandatory. However, preventive measures to be taken generate heated scientific argument. Sunlight exposure particularly in moderation is indeed necessary for health through vitamin D3 synthesis and psychological effects on wellbeing. Vitamin D3 provides numerous biological effects, particularly on bone calcification and also by inhibiting proliferation and migration of malignant cells including melanoma cells. Hence, we are facing the dilemma between too much and too little ultraviolet light exposure. Anyway, one cannot advocate that people lie in the sun until they burn or until they turn a rich brown complexion. [less ▲]

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See detailHow do paedomorphic newts cope with lake drying?
Denoël, Mathieu ULg

in Ecography (2003), 26(4), 405-410

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic ... [more ▼]

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic habitats surrounded by hostile terrestrial environments. Nevertheless, numerous ponds inhabited by paedomorphic individuals are unpredictable and temporary. In an experimental framework, I showed that paedomorphic newts were able to metamorphose and thus survive in the absence of water. However, the mere decrease of water level or the life space do not seem to induce metamorphosis in paedomorphs. On the contrary, drying up induces almost all individuals to move on land and after that to colonize other aquatic sites located nearby. Such terrestrial migrations allow survival in drying conditions without metamorphosis as long as the distances of terrestrial migration are short. These results are consistent with the presence of paedomorphs in drying ponds and are in favor of classic optimality models predicting metamorphosis in unfavorable environments. [less ▲]

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See detailVariations at different spatial scales of Posidonia oceanica (L.) Delile beds; effects on the physico-chemical parameters of the sediment
Gobert, Sylvie ULg; Kyramarios, Michael; Lepoint, Gilles ULg et al

in Oceanologica Acta (2003), 26(2), 199-207

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level ... [more ▼]

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level (100 m2). All the parameters studied, excepting the number of leaves, decrease according to the depth. The horizontal spatial variations (centrifuge and centripetal distributions) reach a maximum in the shallower areas. The analysis of the microstructures (m2) of the meadow has not allowed a relationship to be established between the spatial variations of the biometric parameters and the environmental factors in the sediment (pH, water and organic matter content, red-ox potential, nutrient content). The heterogeneity of the meadow in the Revellata Bay quite probably results from the internal shoot and rhyzome growth dynamics. <br />On the other hand, it appears that the presence of the prairie modifies the physical-chemical characteristics of the sediment. In fact, the sandy patches present different physical-chemical characteristics: lower organic matter, different granulometric and much higher interstitial water nutrient levels, as well as a higher pH and oxydo-reduction potential. [less ▲]

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See detailQuestions à propos du délit d’obstacle à la surveillance en droit belge
Kefer, Fabienne ULg

in Revue Trimestrielle des Droits de l'Homme (2003)

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See detailPhysiology of reproduction and endocrinology in cervids. A review
Drion, Pierre ULg; Hanzen, Christian ULg; Wirth, Delphine - in memoriam et al

in Annales de Médecine Vétérinaire (2003), 147(5), 291-313

Knowledge about cervids are rapidly growing. This work aims to present the more recent scientific information on reproductive physiology and endocrinology of the cervids: anatomy of the genital tract ... [more ▼]

Knowledge about cervids are rapidly growing. This work aims to present the more recent scientific information on reproductive physiology and endocrinology of the cervids: anatomy of the genital tract, length of breeding season, parameters and endocrinology of the reproductive cycle, endocrinology of pregnancy. It also aims to highlight differences between cervids and domestic ruminants such as embryonic diapause observed in Capreolus capreolus. [less ▲]

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See detailL'immersion linguistique dans l'enseignement fondamental en Communauté française de Belgique
Blondin, Christiane ULg

in Journal de l'Immersion (2003), 25(2), 19-31

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See detailvaria
Martiniello, Marco ULg; Guillon, Michelle

in Revue Européenne des Migrations Internationales (2003), 19(1),

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See detailClonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases.
Herens, Christian ULg; Baron, Frédéric ULg; Croisiau, Christiane et al

in Cancer Genetics & Cytogenetics (2003), 147(1), 78-80

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal ... [more ▼]

Imatinib mesylate (tested as STI571), an abl kinase inhibitor, induces sustained, complete hematologic and cytogenetic responses in chronic myelocytic leukemia (CML) patients; however, emergence of clonal chromosomal aberrations in Philadelphia-negative (Ph-) cells during treatment has been reported. We describe two CML patients in chronic phase who presented with complete cytogenetic responses during imatinib mesylate therapy but developed new clonal chromosomal rearrangements in Ph- cells. The first patient presented with a duplication of chromosome 1, dup(1)(q21q42), and the second showed two new clonal aberrations consisting of inv(1)(q12q32) and del(7)(q22) in the same clone. [less ▲]

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See detailLes mycoplasmes respiratoires bovins: prévalence et propriétés de cyto-adhésion
Thomas, A.; Dizier, Isabelle ULg; SACHSE, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 267-272

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See detailUltrastructural Changes Associated With Cryopreservation Of Banana (Musa Spp.) Highly Proliferating Meristems
Helliot, B.; Swennen, R.; Poumay, Y. et al

in Plant Cell Reports (2003), 21(7), 690-698

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See detailField-dependent vortex pinning strength in a periodic array of antidots
Silhanek, Alejandro ULg; Raedts, S.; Lange et al

in Physical Review. B : Condensed Matter (2003), 67(6),

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime ... [more ▼]

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime, vortex motion is of intravalley type and the penetration depth is related to the curvature of the pinning potential well alpha. For dc fields below the first matching field H-1, alpha reaches its highest value associated with a Mott insulator like phase where vortex lines are strongly localized at the pinning sites. For H-1<H-dc<H-2, the response is mainly due to the interstitial vortices and α drops to smaller values as expected for this metallic like regime. Strikingly, for H-2<H-dc<H-3, we observe that α reduces further down. However, for H-3<H-dc<H-4, a reentrance in the pinning strength is observed, due to a specific configuration of the flux-line lattice which strongly restricts the mobility of vortices. We present a possible explanation for the measured α(H-dc) dependence based on the different flux-line lattice configurations. [less ▲]

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See detailRole of acetaldehyde in ethanol-induced conditioned taste aversion in rats
Escarabajal, Dolores M.; De Witte, Philippe; Quertemont, Etienne ULg

in Psychopharmacology (2003), 167(2), 130-136

Rationale: In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol. Objectives: The present ... [more ▼]

Rationale: In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol. Objectives: The present study reexamined the role of acetaldehyde in ethanol-induced conditioned taste aversion (CTA). A first experiment compared ethanol- and acetaldehyde-induced CTA. In a second experiment, cyanamide, an aldehyde dehydrogenase inhibitor, was administered before conditioning with either ethanol or acetaldehyde to investigate the effects of acetaldehyde accumulation. Methods: A classic CTA protocol was used to associate the taste of a saccharin solution with either ethanol or acetaldehyde injections. In experiment 1, saccharin consumption was followed by injections of either ethanol (0, 0.5, 1.0, 1.5 or 2.0 g/kg) or acetaldehyde (0, 100, 170 or 300 mg/kg). In experiment 2, the rats were pretreated with either saline or cyanamide (25 mg/kg) before conditioning with either ethanol or acetaldehyde. Results: Both ethanol and acetaldehyde induced significant CTA. However, ethanol produced a very strong CTA relative to acetaldehyde that induced only a weak CTA even at toxic doses. Cyanamide pretreatments significantly potentiated ethanol- but not acetaldehyde-induced CTA. Conclusions: The present results indicate that ethanol-induced CTA does not result from brain acetaldehyde effects. In contrast, it is suggested that the reinforcing effects of brain acetaldehyde might actually reduce ethanol-induced CTA. Our results also suggest that the inhibition of brain catalase activity may contribute to the potentiating effects of cyanamide on ethanol-induced CTA. [less ▲]

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See detailMycoplasma bovis : synthèse des connaissances actuelles
Thomas, Anne; Mainil, Jacques ULg; Linden, Annick ULg

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 23-39

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia ... [more ▼]

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia, arthritis and mastitis, and is thus associated with strong economic losses. Several studies have shown the frequency of M. bovis in Europe and the spread of antibiotic-resistant strains. Considering the absence of vaccine in Europe, it is essential to understand this bacteria in order to control the infection in cattle. In this context, this paper aims at summarizing the current knowledge about M. bovis. [less ▲]

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See detailL’anabaptisme au Pays de Liège (1533-1593)
Donneau, Olivier ULg

in Annuaire d'Histoire Liégeoise (2003), 32

Study of the spread of the anabaptists movements in the ecclesiastical principality of Liège during the 16th Century.

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See detailHDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.
Dequiedt, Franck ULg; Kasler, Herbert; Fischle, Wolfgang et al

in Immunity (2003), 18(5), 687-98

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and ... [more ▼]

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and negative selection, via the transcription factor MEF2D. HDAC7 is exported from the nucleus during T cell receptor activation, leading to Nur77 expression. A triple HDAC7 mutant (S155A, S318A, S448A) is not exported from the nucleus in response to TCR activation and suppresses TCR-mediated apoptosis. Conversely, a fusion of HDAC7 to the transcriptional activator VP16 activates Nur77 expression. Inhibition of HDAC7 expression by RNA interference causes increased apoptosis in response to TCR activation. These observations define HDAC7 as a regulator of Nur77 and apoptosis in developing thymocytes. [less ▲]

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See detailImpact of medical specialist' locus of control on communication skills in oncological interviews
Libert, Y.; Janne, P.; Razavi, D. et al

in British Journal of Cancer (2003), 88

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See detailClass II histone deacetylases: versatile regulators.
Verdin, Eric; Dequiedt, Franck ULg; Kasler, Herbert G

in Trends in Genetics (2003), 19(5), 286-93

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine ... [more ▼]

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in the histone N-terminal tails and are found in large multiprotein complexes with transcriptional co-repressors. Human HDACs are grouped into three classes based on their similarity to known yeast factors: class I HDACs are similar to the yeast transcriptional repressor yRPD3, class II HDACs to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated as global regulators of gene expression during cell differentiation and development. We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. [less ▲]

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See detailL'image du mois. Un chancre mou.
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(2), 64-6

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See detailRegional variability in mottled subclinical melanoderma in the elderly.
Petit, Ludivine; Fogouang, L.; Uhoda, Isabelle et al

in Experimental Gerontology (2003), 38(3), 327-31

The density in melanin chromatophores becomes heterogeneous in the epidermis during the early events of photoaging. Little is known about the regional variability in the resulting mottled skin appearance ... [more ▼]

The density in melanin chromatophores becomes heterogeneous in the epidermis during the early events of photoaging. Little is known about the regional variability in the resulting mottled skin appearance on the sun-exposed parts of the body in the elderly. The relationship between these features and the dermal atrophy related to aging is also an area ripe for study. The aim of the present study was to objectively assess and compare such aspects of photoaging in older subjects. A computer-assisted video camera equipped with an internal ultraviolet-emitting unit (Visioscan) was used in combination with image analysis to quantify the infraclinical mottling of the skin on the forehead, neck and dorsal forearm. A Densi Score device served to assess the dermal atrophy by rating the skin folding capacity. A mottled subclinical melanoderma was disclosed on the three evaluation sites in all subjects irrespective of their phototypes. Three main patterns were identified corresponding to regular perifollicular dots, streaky macules along shallow wrinkles and unevenly shaped macules in the interfollicular area. The extent in melanoderma was larger on the forehead than on the neck and forearm. The age after 60 years did not influence the severity of mottled melanoderma, but clearly altered the skin folding capacity. The greatest inter-individual differences in mottled melanoderma were found in phototype II subjects. In conclusion, infraclinical mottled melanoderma is present in all individuals after 60 years of age. This type of epidermal photoaging does not appear to be influenced in older ages. By contrast, skin laxity due to dermal aging continues to progress beyond the age of 60 years. [less ▲]

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See detailProcessing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.
De Cat, Bart; Muyldermans, Sin*-Ya; Coomans, Christien et al

in Journal of Cell Biology (2003), 163(3), 625-35

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 ... [more ▼]

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 core protein is processed by a furinlike convertase. This processing is essential for GPC3 modulating Wnt signaling and cell survival in vitro and for supporting embryonic cell movements in zebrafish. The processed GPC3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical Wnt signaling additionally require substitution of the core protein with heparan sulfate. Wnt 5A physically associates only with processed GPC3, and only a form of GPC3 that can be processed by a convertase is able to rescue epiboly and convergence/extension movements in GPC3 morphant embryos. Our data imply that the Simpson-Golabi-Behmel syndrome may in part result from a loss of GPC3 controls on Wnt signaling, and suggest that this function requires the cooperation of both the protein and the heparan sulfate moieties of the proteoglycan. [less ▲]

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See detailFronts and mesoscale variability in the southern Indian Ocean as inferred from the TOPEX/POSEIDON and ERS-2 altimetry data
Kostianoy, Andrey G.; Ginzburg, Anna I.; Lebedev, Sergey Anatolievich et al

in Oceanology (2003), 43(5, SEP-OCT), 632-642

Charts of sea level anomalies (SLA) based on the combined altimetry data from the TOPEX/POSEIDON and ERS-2 satellites, as well as the corresponding charts of the sea surface dynamic heights (constructed ... [more ▼]

Charts of sea level anomalies (SLA) based on the combined altimetry data from the TOPEX/POSEIDON and ERS-2 satellites, as well as the corresponding charts of the sea surface dynamic heights (constructed by the superposition of SLA distributions over the climatic dynamic topography) and the temperature gradients at the ocean surface on the basis of the satellite Multi-Channel Sea Surface Temperature (MCSST) data, were used to study the mesoscale variability related to the fronts in the Southern Indian Ocean (30degrees-60degrees S, 20degrees-150degrees E). An analysis of these three types of satellite information for the central weeks of each month during the period from 1997 to 1999 allowed us to distinguish zones of enhanced meandering (eddy formation) within the basin under study, as well as the contributions of individual fronts and their interaction to the regional mesoscale variability. The problems of the correlation between the intensity of mesoscale variability and peculiarities of the local bottom topography and seasonal/interannual variability of mesoscale dynamics are addressed. [less ▲]

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See detailIntensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al

in Blood (2003), 102(13), 4284-4289

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; De Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Pratique Vétérinaire Equine (2003), 35(139), 23-29

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ... [more ▼]

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ipratropium bromide have been tested. This study is to evaluate the efficacy of the synthetic antimuscarinic compound glycopyrrolate as a bronchodilator in horses. Respiratory crisis was induced in seven allergic horses by exposure to natural allergens. Prior to the study, it was established that the attack could be stopped using intravenous atropine sulphate. Pulmonary function tests (ventilation and arterial blood gas analysis) were performed on the horses before and then after aerosol administration of 1500 µg of glycopyrrolate (Robinul®). The attack was characterised by an increase in total pulmonary resis¬tance and maximum pleural pressure variation and by decreased compliance. This study demonstrates that glycopyrrolate exhibits affects that are just as rapid and effective as intravenous atropine or aerosol administration of 1200 µg dry powder Ipratropium. In addi¬tion the treatment was well tolerated and no side-effects were observed in contrast to those seen with intravenous administration of atro¬pine. Therefore this drug has an important role to play among the therapeutics available to practitioners for acute respiratory attacks in horses [less ▲]

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See detailDysphagia Caused by Ventricular Pseudoaneurysm
Noukoua, C. T.; NCHIMI LONGANG, Alain ULg; Biquet, J. F. et al

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2003), 86(3, May-Jun), 168-9

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See detailFrom the germinal cells to the newborn animal: The transmission of genes and life through the generations
Drion, Pierre ULg; Szenci, Otto; Ectors, Fabien ULg et al

in Acta Veterinaria Hungarica (2003), 51(3), 371-384

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most ... [more ▼]

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most spectacular manipulations are cloning and transgenesis. This review focuses on the early appearance of germinal cell precursors and the long-standing fate of gametes in mammals. The evident complexity and long-term programming of events in gametes and early embryos explain part of the difficulties encountered during the development of in vitro and in vivo methods such as multiple Ovulation and embryo transfer (MOET), oestrus synchronisation, ovulation induction, superovulation, in vitro maturation and fertilisation, cryopreservation, transgenesis, nuclear transfer and cloning) and the occurrence of unexpected alterations of development, e.g. embryonic or fetal mortality, large-weight newborn syndrome and other dysregulations ill imprinting or DNA transmission. [less ▲]

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See detailResource partitioning in two heterochronic populations of Greek Alpine newts, Triturus alpestris veluchiensis
Denoël, Mathieu ULg; Schabetsberger, R.

in Acta Oecologica: International Journal of Ecology (2003), 24(1), 55-64

Current ecological models suggest that the maintenance of trophic polymorphisms is favoured by a different resource use in alternative morphs. Facultative paedomorphosis in newts is an example of ... [more ▼]

Current ecological models suggest that the maintenance of trophic polymorphisms is favoured by a different resource use in alternative morphs. Facultative paedomorphosis in newts is an example of phenotypic variation as paedomorphs retain morphological larval traits, such as gills and gill slits. The aim of this study was to find out whether heterochronic morphs occupy particular micro-habitats and focus on specific prey items. Resource partitioning was found between morphs. It concerns mainly food selection with paedomorphs preying more on plankton and less on terrestrial invertebrates than metamorphs. Some habitat specializations were also found with metamorphs being more abundant at the water surface than paedomorphs. Diel variation in habitat use of the two different morphs was minimal. Polymorphism allows Alpine newts to exploit the different resources in the lakes in order to minimize intraspecific competition, but the extent of resource partitioning depends on habitat characteristics. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved. [less ▲]

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See detailDynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus: differences in PCB profile between compartments of transfer and changes during the lactation period
Debier, Cathy; Pomeroy, Paddy P.; Dupont, Cédric et al

in Marine Ecology-Progress Series (2003), 247

The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber ... [more ▼]

The composition of the PCB mixture which is transferred from mother to pup in grey seals Halichoerus grypus throughout lactation was measured in the successive compartments of transfer: maternal blubber, maternal serum, milk and pup serum. Mother-pup pairs were captured regularly between birth and weaning on the Isle of May, Scotland. The PCB profiles of the different compartments of transfer consisted mainly of congeners 153, 138, 180, 187, 170 and 101, which made up 85% of the total PCB burden. Outer blubber contained higher relative concentrations (R-153) Of hepta-, octa-, and nona-chlorinated congeners (higher chlorinated congeners) than inner blubber, at both early (less than or equal to 5 d) and late (greater than or equal to 11 d) lactation. There was no change in the composition of the outer blubber layer between early and late lactation, while in the inner blubber, there was a slight increase in the R153 of higher chlorinated congeners at late lactation. In maternal serum, profiles changed towards having a higher proportion of higher chlorinated congeners as lactation progressed, but in milk, the PCB pattern stayed constant throughout lactation. Surprisingly, in pup serum profiles also changed towards higher R153 of higher chlorinated congeners at late lactation compared to early lactation, which was different to the pattern observed in milk. In all body compartments, higher proportions of higher chlorinated congeners were associated with higher concentrations of total PCBs. Maternal blubber and pup serum contained a higher R153 of higher chlorinated congeners than milk and, to a lesser extent, maternal serum. Thus biomagnification of the higher chlorinated congeners was recorded in pup serum. [less ▲]

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See detailHierarchically mesoporous/macroporous metal oxides templated from polyethylene oxide surfactant assemblies
Blin, J.-L.; Léonard, Alexandre ULg; Yuan, Z.-Y. et al

in Angewandte Chemie International Edition (2003), 42(25), 2872-2875

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like ... [more ▼]

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like shape (tapered towards the center) and are arranged parallel to each other and perpendicular to the tangent of the particle surface (see micrographs). The mesochannels are interconnected with funnel-like macrochannels. [less ▲]

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See detailMons/Maisières : les occupations paléolithiques de "l'Atelier de Taille de la Berge Nord-Est" à Maisières-Canal
Miller, Rebecca ULg; Guillaume, Alain; Otte, Marcel ULg

in Chronique de l'Archéologie Wallonne (2003), 11

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See detailHydrodynamique et morphologie d'une bactérie filamenteuse dans un fermenteur à cuve agitée
Groslambert, Sylvie ULg; Blacher, Silvia ULg; Crine, Michel ULg

in Tribune de l'Eau (La) (2003), 56(622), 58-64

Afin d'étudier l'influence de l'hydrodynamique sur une bactérie filamenteuse, Actinomadura R39, nous l'avons cultivée dans un fermenteur de laboratoire de 5 litres à cuve agitée en faisant varier les ... [more ▼]

Afin d'étudier l'influence de l'hydrodynamique sur une bactérie filamenteuse, Actinomadura R39, nous l'avons cultivée dans un fermenteur de laboratoire de 5 litres à cuve agitée en faisant varier les conditions d'agitation. Les variables sont la vitesse de rotation et le type de mobile utilisé: turbines Rushton ou Intermig. Les deux mobiles se distinguent par leur géométrie et par les schémas d'écoulement qu'ils induisent dans la cuve. L'influence de l'hydrodynamique sur Actinomadura R39 est quantifiée par l'évolution de sa morphologie. Cette dernière est estimée par analyse d'images sur des échantillons prélevés lors des cultures. Parallèlement, nous avons caractérisé l'hydrodynamique du fermenteur dans un milieu artificiel reproduisant la rhéologie des fermentations en mesurant la puissance dissipée et en effectuant des essais de traceurs. Ces derniers sont utilisés pour la modélisation du fermenteur par un modèle compartimenté et le calcul du temps de mélange. Nous avons pu ainsi mettre en relation les modifications de la morphologie et des grandeurs caractérisant les écoulements dans le fermenteur. L'existence de corrélations entre les paramètres du modèle et la morphologie a également permis une validation de la signification physique de ce modèle. [less ▲]

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See detailPreoperative hyperfractionated acclerated radiotherapy (HART) and concomittant CPT-11 in advanced rectal carcinoma. A phase I study.
Voelter, V; Stupp, R; Matter, M et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 56(5), 1288-1294

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated ... [more ▼]

Purpose: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated radiotherapy (HART). In this Phase I trial, we aimed at introducing chemotherapy early in the treatment course with both intrinsic antitumor activity and a radiosensitizer effect. Methods and Materials: Twenty-eight patients (19 males; median age 63, range 28–75) with advanced rectal carcinoma (cT3: 24; cT4: 4; cN : 12; M1: 5) were enrolled, including 8 patients treated at the maximally tolerated dose. Escalating doses of CPT-11 (30–105 mg/m2/week) were given on Days 1, 8, and 15, and concomitant HART (41.6 Gy, 1.6 Gy bid 13 days) started on Day 8. Surgery was to be performed within 1 week after the end of radiochemotherapy. Results: Twenty-six patients completed all preoperative radiochemotherapy as scheduled; all patients underwent surgery. Dose-limiting toxicity was diarrhea Grade 3 occurring at dose level 6 (105 mg/m2). Hematotoxicity was mild, with only 1 patient experiencing Grade 3 neutropenia. Postoperative complications (30 days) occurred in 7 patients, with an anastomotic leak rate of 22%. Conclusions: The recommended Phase II dose of CPT-11 in this setting is 90 mg/m2/week. Further Phase II exploration at this dose is warranted. © 2003 Elsevier Inc. [less ▲]

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See detailPlmA, a new member of the GntR family, has plasmid maintenance functions in Anabaena sp. strain PCC 7120
Lee, M. H.; Scherer, K.; Rigali, Sébastien ULg et al

in Journal of Bacteriology (2003), 185(15), 4315-4325

The filamentous cyanobacterium Anabaena (Nostoc) sp. strain PCC 7120 maintains a genome that is divided into a 6.4-Mb chromosome, three large plasmids of more that 100 kb, two medium-sized plasmids of 55 ... [more ▼]

The filamentous cyanobacterium Anabaena (Nostoc) sp. strain PCC 7120 maintains a genome that is divided into a 6.4-Mb chromosome, three large plasmids of more that 100 kb, two medium-sized plasmids of 55 and 40 kb, and a 5.5-kb plasmid. Plasmid copy number can be dynamic in some cyanobacterial species, and the genes that regulate this process have not been characterized. Here we show that mutations in an open reading frame, all1076, reduce the numbers of copies per chromosome of several plasmids. In a mutant strain, plasmids pCC7120delta and pCC7120zeta are both reduced to less than 50% of their wild-type levels. The exogenous pDU1-based plasmid pAM1691 is reduced to less than 25% of its wild-type level, and the plasmid is rapidly lost. The peptide encoded by all1076 shows similarity to members of the GntR family of transcriptional regulators. Phylogenetic analysis reveals a new domain topology within the GntR family. PlmA homologs, all coming from cyanobacterial species, form a new subfamily that is distinct from the previously identified subfamilies. The all1076 locus, named plmA, regulates plasmid maintenance functions in Anabaena sp. strain PCC 7120. [less ▲]

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See detailDetuning effects in the one-photon mazer
Bastin, Thierry ULg; Martin, John ULg

in Physical Review. A (2003), 67

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far ... [more ▼]

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far from being direct. Interesting effects of the mazer physics are pointed out. In particular, it is shown that the cavity may slow down or speed up the atoms according to the sign of the detuning and that the induced emission process may be completely blocked by use of a positive detuning. It is also shown that the detuning adds a potential step effect not present at resonance and that the use of positive detunings defines a well-controlled cooling mechanism. In the special case of a mesa cavity mode function, generalized expressions for the reflection and transmission coefficients have been obtained. The general properties of the induced emission probability are finally discussed in the hot, intermediate, and cold atom regimes. Comparison with the resonant case is given. [less ▲]

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See detailAltered neuronal excitability in cerebellar granule cells of mice lacking calretinin
Gall, D.; Roussel, C.; Susa, I. et al

in Journal of Neuroscience (2003), 23(28), 9320-9327

Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar ... [more ▼]

Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar granule cells, which provide the major excitatory input to Purkinje cells through parallel fibers. Calretinin-deficient mice exhibit dramatic alterations in motor coordination and Purkinje cell firing recorded in vivo through unknown mechanisms. In the present study, we used patch-clamp recording techniques in acute slice preparation to investigate the effect of a null mutation of the calretinin gene on the intrinsic electroresponsiveness of cerebellar granule cells at a mature developmental stage. Calretinin-deficient granule cells exhibit faster action potentials and generate repetitive spike discharge showing an enhanced frequency increase with injected currents. These alterations disappear when 0.15 mm of the exogenous fast-calcium buffer BAPTA is infused in the cytosol to restore the calcium-buffering capacity. A proposed mathematical model demonstrates that the observed alterations of granule cell excitability can be explained by a decreased cytosolic calcium-buffering capacity resulting from the absence of calretinin. This result suggests that calcium-binding proteins modulate intrinsic neuronal excitability and may therefore play a role in information processing in the CNS [less ▲]

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See detailp-mode Oscillations of alpha Cen A
Thoul, Anne ULg; Scuflaire, Richard ULg; Vatovez, B. et al

in Astrophysics & Space Science (2003), 284

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (2002) and the data derived from the spectroscopic analysis of Neuforge and Magain (1997). The seismological ... [more ▼]

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (2002) and the data derived from the spectroscopic analysis of Neuforge and Magain (1997). The seismological data obtained by Bouchy and Carrier (2001, 2002) do help improve our knowledge of the evolutionary status of the system. All the constraints are satisfied with a model which gives an age of about 6 Gyr for the binary. [less ▲]

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See detailEpidemiology, clinical presentation and diagnostic strategy of gastro-esophageal reflux
Louis, Edouard ULg

in Acta Endoscopica (2003), 33

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See detailIncreased electron donor and electron acceptor characters enhance the adhesion between oil droplets and cells of Yarrowia lipolytica as evaluated by a new cytometric assay
Aguedo, Mario ULg; Waché, Y.; Mazoyer, V. et al

in Journal of Agricultural and Food Chemistry (2003), 51(10), 3007-3011

The adhesion of methyl ricinoleate droplets to cells of the yeast Yarrowia lipolytica was investigated. A new cytometric method, relying on the double staining of fatty globules with Nile Red and of cells ... [more ▼]

The adhesion of methyl ricinoleate droplets to cells of the yeast Yarrowia lipolytica was investigated. A new cytometric method, relying on the double staining of fatty globules with Nile Red and of cells with Calcofluor, enabled us to quantify methyl ricinoleate droplet adhesion to cells precultured on a hydrophilic or on a hydrophobic carbon source. In this last case, droplet adsorption was enhanced and a MATS (microbial adhesion to solvents) test revealed that this increase was due to Lewis acid-base interactions and not to an increase in the hydrophobic properties of the cell surface. These preliminary results demonstrate that the developed cytometric method is promising for various applications concerning the study of interactions between microorganisms and an emulsified hydrophobic substrates. [less ▲]

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See detailRétention gazeuse dans une colonne à bulles contenant un liquide visqueux non-newtonien
Fransolet, Emmanuelle; Coumont, V.; Crine, Michel ULg et al

in Tribune de l'Eau (La) (2003), 56(622), 15-20

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See detailNMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains.
Liepinsh, Edvards; Genereux, Catherine ULg; Dehareng, Dominique ULg et al

in Journal of Molecular Biology (2003), 327(4), 833-42

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway ... [more ▼]

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway for the acquisition of constitutive antibiotic resistance. Here, we report the NMR structure of AmpD from Citrobacter freundii (PDB accession code 1J3G). A deep substrate-binding pocket explains the observed specificity for low molecular mass substrates. The fold is related to that of bacteriophage T7 lysozyme. Both proteins bind zinc at a conserved site and require zinc for amidase activity, although the enzymatic mechanism seems to differ in detail. The structure-based sequence alignment identifies conserved features that are also conserved in the eukaryotic peptidoglycan recognition protein (PGRP) domains, including the zinc-coordination site in several of them. PGRP domains thus belong to the same fold family and, where zinc-binding residues are conserved, may have amidase activity. This hypothesis is supported by the observation that human serum N-acetylmuramyl-L-alanine amidase seems to be identical with a soluble form of human PGRP-L. [less ▲]

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See detailQuels rôles et quelle formation pour les tuteurs intervenant dans des dispositifs de formation à distance ?
Denis, Brigitte ULg

in Distances et Savoirs (2003), 1(1), 19-46

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif ... [more ▼]

Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. Cet article traite de la formation de « tuteurs en ligne », c’est-à-dire intervenant dans un dispositif de formation à distance. Après avoir situé le tuteur parmi les autres acteurs d’un tel dispositif, l’auteur envisage différentes fonctions tutorales et un profil d’intervention à relativiser selon le type de dispositif de formation envisagé. Il présente ensuite une série de compétences nécessaires pour devenir tuteur à distance ainsi que diverses expériences de formation de tuteurs. Il propose sept étapes de formation allant du vécu d’une expérience d’apprentissage à distance par le futur tuteur jusqu’à la régulation de ses interventions. [less ▲]

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See detailTwo new atrypid brachiopod species from the late Frasnian of Belgium
Mottequin, Bernard ULg

in Bulletin de l'Institut Royal des Sciences Naturelles de Belgique. Sciences de la Terre (2003), 73

Two new species of atrypid brachiopods from the late Frasnian Lambermont and Barvaux formations of Belgium are described (south-east border of the Dinant and the Vesdre Nappe), Iowatrypa ultima n. sp. and ... [more ▼]

Two new species of atrypid brachiopods from the late Frasnian Lambermont and Barvaux formations of Belgium are described (south-east border of the Dinant and the Vesdre Nappe), Iowatrypa ultima n. sp. and Spinatrypa (Spinatrypa) lambermontensis n. sp. These species rank among the last representatives of the order Atrypida in the Ardennes (Upper Palmatolepis rhenana Zone). [less ▲]

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See detailA new method for reconstruction of the vertical electron density distribution in the upper ionosphere and plasmasphere
Stankov, Stanimir; Jakowski, Norbert; Muhtarov, Plamen et al

in Journal of Geophysical Research. Space Physics (2003), 108(A51164), 1164

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See detailLa libre circulation des personnes dans l’Union européenne. Chronique de jurisprudence et de législation
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2003), 11(107), 79

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See detailFaillite de l'imaginaire, la dermatite atopique ?
Dracoulis, H.; Gauthier, Jean-Marie ULg

in Revue Française de Psychiatrie et de Psychologie Médicale (2003), 7(66), 51-56

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See detailComment j'explore ... la cinetique glycemique des patients diabetiques par monitoring continu du glucose interstitiel.
Radermecker, Régis ULg; Magis, Delphine ULg; Selam, J. L. et al

in Revue Médicale de Liège (2003), 58(3), 164-7

The improvement of diabetic patients' glycaemic status requires an increase of fingerstick blood glucose measurements. Among the possibilities available to assess diabetes' control, we will consider new ... [more ▼]

The improvement of diabetic patients' glycaemic status requires an increase of fingerstick blood glucose measurements. Among the possibilities available to assess diabetes' control, we will consider new systems of continuous interstitial glucose monitoring. After a brief description of the devices presently commercialized, we will discuss their indications and their limitations, as well as their future prospects in a possible "closed loop" insulin delivery according to blood glucose level. [less ▲]

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See detailAnalyses technologiques d’un atelier de taille aurignacien à Maisières-Canal (Province du Hainaut, Belgique)
Miller, Rebecca ULg; Flas, Damien ULg; Guillaume, Alain et al

in Notae Praehistoricae (2003), 23

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See detailLetter To The Editor
Groß-Hardt, E; Henschke, M; Pfennig, Andreas ULg

in AIChE Journal (2003), 49(6), 1610-1611

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See detailCalculation of optical absorption spectra of hydrogenated Si clusters: Bethe-Salpeter equation versus time-dependent local-density approximation
Benedict, L. X.; Puzder, A.; Williamson, A. J. et al

in Physical Review. B : Condensed Matter (2003), 68(8), 85310-1-85310-85310-885310-85310-8

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE ... [more ▼]

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE) with a model dielectric function, and the time-dependent density-functional theory within the adiabatic local-density approximation (TDLDA). Single-particle states are obtained from local-density approximation (LDA) calculations and, for the BSE calculation, a quasiparticle gap correction is provided by quantum Monte Carlo calculations. We find that the exchange-correlation kernel of the TDLDA has almost no effect on the calculated spectra, while the corresponding attractive part of the electron-hole interaction of the BSE produces enhanced absorptive features at low energies. For the smallest cluster SiH 4, the two methods produce markedly different results, with the TDLDA spectra appearing closer to the experimental result. The gross features of the TDLDA and BSE spectra for larger clusters are however similar, due to the strong repulsive Coulomb kernel present in both treatments [less ▲]

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See detailToward a better control of internal structure and external morphology of mesoporous silicas synthesized using a nonionic surfactant
Léonard, Alexandre ULg; Blin, J. L.; Robert, M. et al

in Langmuir (2003), 19(13), 5484-5490

Mesoporous silicas with controlled morphologies have been synthesized using decaoxyethylene cetyl ether [C 16(EO) 10] as a surfactant (10 wt % in aqueous solution). A large series of characterization ... [more ▼]

Mesoporous silicas with controlled morphologies have been synthesized using decaoxyethylene cetyl ether [C 16(EO) 10] as a surfactant (10 wt % in aqueous solution). A large series of characterization results (SEM, TEM, XRD, and nitrogen adsorption-desorption analysis) have demonstrated how the surfactant/silica molar ratio as well as hydrothermal treatment conditions can drastically influence not only the regular organization of the compounds on the nanometer scale but also the morphogenesis of the particles at the micrometer level. High loadings of a silica precursor yield highly structured mesoporous compounds with a morphology of ropes, gyroids and toroids whereas an increase of the surfactant/silica molar ratio results in spherical materials with a disordered channel array. A phase transition from hexagonal to disordered structure and then again to a regular hexagonal array with increasing gel heating temperature from 40 to 80°C has been evidenced. [less ▲]

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See detailCompte-rendu de l'ouvrage de R. De Smet (éd.), Les Humanistes et leur bibliothèque
Adam, Renaud ULg

in Scriptorium (2003), 57(1), 167

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See detailFungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.
Francis, Frédéric ULg; Marty-Detraves, Claire; Poincloux, Renaud et al

in European Journal of Cell Biology (2003), 82(10), 515-22

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect ... [more ▼]

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect-resistant transgenic plants, we investigated the effects of XCL at the cellular level. Immunofluorescence microscopy studies revealed that XCL is rapidly internalized into small endocytic vesicles that further coalesce in the perinuclear region. We show that XCL is endocytosed by the clathrin-dependent pathway, and is delivered to late endosome/lysosome compartments. The internalization of XCL seems to be general since it occurs in different cell types such as insect (SF9) or mammalian (NIH-3T3 and Hela) cell lines. In the presence of XCL, the uptake of GFP and BSA is greatly enhanced, demonstrating that XCL facilitates endocytosis. Thus, XCL could serve as a delivery agent to facilitate the endocytosis of proteins that do not enter the cell alone. [less ▲]

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See detailOrchesia luteipalpis Mulsant et Guillebeau, 1857 (Coleoptera: Serropalpidae), nouvelle espèce pour la faune belge
Thieren, Yves; Fagot, Jean ULg; Lhoir, Jonathan

in Notes Fauniques de Gembloux (2003), 50

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See detailT-cell reconstitution after unmanipulated, CD8-depleted or CD34-selected nonmyeloablative peripheral blood stem-cell transplantation.
Baron, Frédéric ULg; Schaaf-Lafontaine, Nicole ULg; Humblet-Baron, Stéphanie ULg et al

in Transplantation (2003), 76(12), 1705-13

BACKGROUND: We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem ... [more ▼]

BACKGROUND: We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem-cell transplantation (NMSCT). In this study, we analyze the effect of CD8 depletion or CD34 selection of the graft on early T-cell reconstitution. METHODS: Nonmyeloablative conditioning regimen consisted in 2 Gy total-body irradiation (TBI) alone, 2 Gy TBI and fludarabine, or cyclophosphamide and fludarabine. Patients 1 to 18 received unmanipulated PBSC, patients 19 to 29 CD8-depleted PBSC, and patients 30 to 35 CD34-selected PBSC. RESULTS: T-cell counts, and particularly CD4+ and CD4CD45RA+ counts, remained low the first 6 months after nonmyeloablative stem-cell transplantation (NMSCT) in all patients. CD34 selection (P<0.0001) but not CD8 depletion of PBSC significantly decreased T-cell chimerism. Donor T-cell count was similar in unmanipulated compared with CD8-depleted PBSC recipients but was significantly lower in CD34-selected PBSC recipients (P=0.0012). T cells of recipient origin remained stable over time in unmanipulated and CD8-depleted PBSC patients but expanded in some CD34-selected PBSC recipients between day 28 and 100 after transplant. Moreover, whereas CD8 depletion only decreased CD8+ counts (P<0.047), CD34 selection reduced CD3+(P<0.001), CD8+(P<0.016), CD4+ (P<0.001), and CD4+CD45RA+ (P<0.001) cell counts. T-cell repertoire was restricted in all patients on day 100 after hematopoietic stem-cell transplantation but was even more limited after CD34 selection (P=0.002). CONCLUSIONS: Despite of the persistence of a significant number of T cells of recipient origin, T-cell counts were low the first 6 months after NMSCT. Moreover, contrary with CD8 depletion of the graft that only affects CD8+ lymphocyte counts, CD34 selection dramatically decreased both CD8 and CD4 counts. [less ▲]

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See detailTime-dependent behaviour of oil reservoir chalk: A multiphase approach
De Gennaro, Vincenzo; Delage, Pierre; Cui, Yu Jun et al

in Soils and Foundations (2003), 43(4),

In the North Sea Ekofisk oilfield, oil is located in a 300 m thick layer of porous chalk (n = 40-50%) at a 3000 m depth. After the initial phase of depletion an enhanced oil recovery procedure was carried ... [more ▼]

In the North Sea Ekofisk oilfield, oil is located in a 300 m thick layer of porous chalk (n = 40-50%) at a 3000 m depth. After the initial phase of depletion an enhanced oil recovery procedure was carried out by injecting sea water (waterflooding). An unexpected consequence of this waterflooding has been the occurrence of a seafloor subsidence, corresponding up to now to a decrease of the seafloor level of approximately 10 m. It is now well recognised that hydro-mechanical coupling involving multiphase fluid interactions (oil and water) is determinant for the interpretation of the phenomenological aspects associated with the chalk compaction and the related subsidence observed in the North Sea oilfields (Ekofisk reservoir) when water flooded. The subsidence due to waterflooding is interpreted as a collapse phenomenon due to suction decrease, typical of loose and low plasticity unsaturated soils when wetted under load. On the other hand, time-dependent stress-strain behaviour of geomaterials is one of the major concerns in soil mechanics and, in effect, subsidence includes creep effects. A multiphase approach, including creep effects under controlled suction levels, is proposed in this paper; the preliminary results of this study are presented and discussed. Attention will be focused at first on the theoretical approach, supplying the essential elements for the work, and on the interpretation of the experimental results. This will provide secondly the base for formulation and validation of the constitutive law proposed for the description of the time-dependent mechanical behaviour of the chalk. [less ▲]

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See detailDe overmoed van de toevallige standaard
Meesters, Gert ULg

in Over Taal (2003), 42(5), 106-107

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See detailChoice of an adjuvant for vaccination trials
Vermout, Sandy; Denis, M.; Losson, Bertrand ULg et al

in Annales de Médecine Vétérinaire (2003), 147(6), 393-401

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it ... [more ▼]

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it qualitatively. A number of tumors and infectious diseases could be treated with adjuvant preparations that would adequately intensify and modulate specific immune response; in particular, the possibility to specifically induce a Th1 response seems to be of paramount importance for the prevention and for the cure of these diseases. Furthermore, these adjuvants must be as safe as possible, not only for commercial applications, but also in the respect of laboratory animals' welfare. This review describes the different adjuvants presently used in vaccinology, classifying them following their chemical nature and presenting for each category the knowledge concerning their activity and toxicity. [less ▲]

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See detailA magnetic and Mossbauer spectral study of TbFe11Ti and TbFe11TiH
Piquer, C.; Hermann, Raphaël ULg; Grandjean, François-Xavier ULg et al

in Journal of Physics : Condensed Matter (2003), 15(43), 7395-7409

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering ... [more ▼]

Magnetic and iron-57 Mossbauer spectral measurements between 4.2 and 640 K have been carried out on TbFe11Ti and TbFe11TiH. The insertion of hydrogen into TbFe11Ti form TbFe11TiH increases its ordering temperature, magnetization, magnetic hyperfine fields, and isomer shifts as a result of lattice expansion. Further, the insertion of hydrogen reinforces the basal magnetic anisotropy of the terbium sublattice and, as is shown by ac susceptibility measurements and thermomagnetic analysis, the spin reorientation observed in TbFe11Ti at 338 K disappears in TbFe11TiH. The Mossbauer spectra have been analysed with a model that considers both the easy magnetization direction and the distribution of titanium atoms in the near-neighbour environment of the three crystallographically distinct iron sites. The assignment and the temperature dependencies of the hyperfine fields and isomer shifts are in complete agreement with a Wigner-Seitz cell analysis of the three iron sites in RFe11Ti and RFe11TiH, where R is a rare-earth element. A complete analysis of the quadrupole interactions in both magnetic phases and in the paramagnetic phase of TbFe11Ti supports the Mossbauer spectral analysis, and indicates that in the basal magnetic phase the iron magnetic moments are oriented along the equivalent [100] and [010] directions of the unit cell. [less ▲]

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See detailGene flow among wild Phaseolus lunatus L. populations in the Central Valley of Costa Rica
Ouedraogo, M.; Maquet, A.; Baudoin, Jean-Pierre ULg

in Annual Report Bean Improvement Cooperative (2003), 46

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See detailMechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity.
Fillet, Marianne ULg; Bentires-Alj, Mohamed; Deregowski, Valérie et al

in Biochemical Pharmacology (2003), 65(10), 1633-42

Ceramides are important intracellular second messengers that play a role in the regulation of cell growth, differentiation, and programmed cell death. To determine whether ceramides can mediate the ... [more ▼]

Ceramides are important intracellular second messengers that play a role in the regulation of cell growth, differentiation, and programmed cell death. To determine whether ceramides can mediate the apoptosis of HCT116 and OVCAR-3 cancer cells, exogenous C2-, C6-, and C16-ceramides were used to mimic the endogenous lipid increase that follows a large variety of stresses. C2- and C6-ceramides (cell-permeable ceramide analogs), but not C16-ceramide, induced nuclear factor-kappaB (NF-kappaB) DNA-binding, caspase-3 activation, poly(ADP-ribose) polymerase degradation, and mitochondrial cytochrome c release, indicating that apoptosis occurs through the caspase cascade and the mitochondrial pathway. No difference in survival was observed between control cells and cells expressing mutated IkappaBalpha and treated with the permeable ceramides. This suggests that, at least in these cell lines, stable NF-kappaB inhibition did not modify the ceramide-induced cytotoxicity pathway. C6-ceramide also induced a double block in G1 and G2, thus emptying the S phase. [less ▲]

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See detailL'enseignement en Communauté française : un haut degré d'iniquité
Baye, Ariane ULg; Nicaise, Julien; Straeten, Marie-Hélène et al

in Espace de Libertés : Magazine du Centre d'Action Laïque (2003), (316), 16-17

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See detailIneffectiveness of chloroquine antenatal prophylaxis in East of Democratic Republic of Congo (RDC).
Mugisho, E.; Dramaix, M.; Porignon, Denis ULg et al

in Tropical doctor (2003), 33(3), 177-178

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See detailModélisation 3D d’un groupe de pieux pour le pont-canal de Houdeng
Trevisan, Stefano; Li, Xian Ling; Collin, Frédéric ULg et al

in Revue Française de Géotechnique (2003), 105

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group ... [more ▼]

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group of piles and to the quality of the drilled piles of the canal-bridge of Houdeng (Belgium) are analysed in a non conventional fashion, based on a finite element analysis, thanks to sufficient experimental data. The influence of an imperfectly cleaned excavation bottom and of the destructuration of the bottom rocks caused by the drilling of the piles is investigated. A particular attention is also given to the behaviour of a group of piles. [less ▲]

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See detailImmigrants and National Identity in Europe - A. Triandafyllidou
Martiniello, Marco ULg

in Nations & Nationalism (2003), 9(1), 165-166

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