References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 37501 to 37600 of 56318     371 372 373 374 375 376 377 378 379 380 381     Peter Johnson, "Pretty Happy !Delville, Michel in Literary Review (2001)Detailed reference viewed: 23 (0 ULg) An On-line Glossary as a way to foster the construction of a common culture among urban experts, stakeholders and decision-makersTeller, Jacques in Construction Innovation (2001), 1/4Negotiation and public participation are a key aspect of present urban development projects. Argumentation support tools, based on the Toulmin logic, have often been presented as a way to increase the ... [more ▼]Negotiation and public participation are a key aspect of present urban development projects. Argumentation support tools, based on the Toulmin logic, have often been presented as a way to increase the accountability of the debates between the different urban actors. It should still be assumed that any collaborative decision making requires some common culture to make the dialogue possible and constructive. Such a common understanding of basic terms, references and methods is often missing in present-day urban disputes, especially when complex issues like cultural heritage are at stake. The present paper discusses the relevancy of Web Glossaries as a way to build up such a common culture among urban experts, stakeholders and decision-makers. [less ▲]Detailed reference viewed: 40 (5 ULg) Spermine induces precocious development of the spleen in Wistar ratPeulen, Olivier ; Jolois, Olivier ; Galopin, Catherine et alin Trends in Comparative Biochemistry and Physiology (2001), 8Detailed reference viewed: 10 (0 ULg) Moderate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac surgery.Vazquez-Jimenez, J. F.; Qing, M.; Hermanns, B. et alin Journal of the American College of Cardiology (2001), 38(4), 1216-23OBJECTIVES: The goal of this study was to test the hypothesis that moderate hypothermia during cardiopulmonary bypass (CPB) provides myocardial protection by enhancing intra-myocardial anti-inflammatory ... [more ▼]OBJECTIVES: The goal of this study was to test the hypothesis that moderate hypothermia during cardiopulmonary bypass (CPB) provides myocardial protection by enhancing intra-myocardial anti-inflammatory cytokine balance. BACKGROUND: Moderate hypothermia during experimental CPB stimulates production of interleukin-10 (IL10) and blunts release of tumor necrosis factor-alpha (TNFalpha). METHODS: Twelve young pigs were assigned to a temperature (T degrees ) regimen during CPB: moderate hypothermia (T degrees : 28 degrees C; n = 6) and normothermia (T degrees : 37 degrees C; n = 6). Intra-myocardial TNFalpha- and IL10-messenger RNA were detected by competitive reverse transcriptase polymerase chain reaction and quantification of cytokine synthesis by Western blot. Levels of cardiac troponin I (cTnI) in cardiac lymph and in arterial and coronary venous blood were examined during and after CPB. Myocardial cell damage was assessed by histologic and ultrastructural anomalies of tissue probes taken 6 h after CPB. RESULTS: Synthesis of IL10 was significantly higher, while that of TNFalpha was significantly lower, in pigs that were in moderate hypothermia during surgery than in the others. In contrast with normothermia, moderate hypothermia was also associated with significantly lower cumulative cardiac lymphatic flow during and after CPB, significantly lower lymphatic cTnI concentrations after CPB, significantly lower percentages of myocardial cell necrosis and a significantly lower score of ultrastructural anomalies of myocardial cells. While the percentage of apoptotic cells was not different between groups, the apoptosis/necrosis ratio tended to be higher in animals that were in moderate hypothermia during surgery. In all animals, TNFalpha synthesis correlated positively while IL10 production correlated negatively with necrosis and total cell death, respectively. CONCLUSIONS: Our results suggest that moderate hypothermia during CPB provides myocardial protection by enhancing intra-myocardial anti-inflammatory cytokine balance. [less ▲]Detailed reference viewed: 43 (1 ULg) Pre-and post-harvest application of antagonistic yeasts for the control of gray and blue mold: efficacy and monitoringDe Clercq, D.; Dickburt, C.; Lepoivre, Philippe et alin Phytopathology (2001), 91(6), 21Detailed reference viewed: 17 (2 ULg) Role de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumoraleBajou, Khalid ; Devy, L.; Masson, Véronique et alin Thérapie (2001), 56(5, Sep-Oct), 465-72The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen ... [more ▼]The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen activation system, and paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been correlated with a poor prognosis for patients with cancers of different types. Recent findings clearly suggest that PAI-1 is essential for capillary sprouting during tumour angiogenesis. Moreover, there is accumulating evidence that both the urokinase receptor and PAI-1 are multifunctional proteins involved not only in extracellular matrix proteolysis but also in cellular adhesion and migration through their binding site for vitronectin. The understanding of whether PAI-1 plays a regulatory role in angiogenesis by tightly controlling proteolytic activity or by influencing cell migration could allow a new anti-angiogenic approach for tumour therapy. [less ▲]Detailed reference viewed: 44 (14 ULg) Flow rate quality of new flat fan nozzlesHuyghebaert, Bruno; Debouche, Charles ; Mostade, Olivierin Transactions of the ASAE (2001), 44(4), 769-773Manufacturers of spraying nozzles have established manufacturing tolerances to guarantee the quality of their products. They control, among other things, the new nozzles’ flow rate by comparison with the ... [more ▼]Manufacturers of spraying nozzles have established manufacturing tolerances to guarantee the quality of their products. They control, among other things, the new nozzles’ flow rate by comparison with the nominal flow rate. When the deviation exceeds a set limit, the nozzles are rejected. A survey carried out among three manufacturers made it possible to determine the manufacturing tolerances and limits that manufacturers impose upon themselves. The flow rates of 1565 new nozzles collected on the market from these manufacturers were measured on a device developed for this study. Different statistical tests assessed the performances and characteristics of the products. The quality standards announced by the manufacturers were not checked for every nozzle. On average, 20% of the new nozzles exceeded the manufacturing tolerances. The average flow rate of the nozzle sets equalled the nominal flow rate. In practice, the probability distribution of the flow rate of new nozzles should be normal. The dispersion of the new nozzle flow rates was slightly higher than the theoretical one. The quality of the products differed from one manufacturer to another. [less ▲]Detailed reference viewed: 64 (5 ULg) Des gribouillis aux premières lettres : le développement précoce de l’écrit.Maillart, Christelle ; Schelstrate, Marie-Annein Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2001), 34(2), 103-120Detailed reference viewed: 74 (2 ULg) Pharma-clinics. Le medicament du mois. La sibutramine (Reductil).Scheen, André in Revue Médicale de Liège (2001), 56(9), 656-9Sibutramine (Reductil, Abbott-Knoll, 10 mg and 15 mg) is a new appetite regulator recommended in the treatment of obesity. It is a noradrenaline and 5-hydroxytryptamine reuptake inhibitor which exerts its ... [more ▼]Sibutramine (Reductil, Abbott-Knoll, 10 mg and 15 mg) is a new appetite regulator recommended in the treatment of obesity. It is a noradrenaline and 5-hydroxytryptamine reuptake inhibitor which exerts its effects in vivo predominantly via its secondary and primary amine metabolites. Sibutramine is indicated as an adjunctive therapy within a weight management programme in patients with obesity (BMI > or = 30 kg/m2) or in overweight subjects (BMI > or = 27 kg/m2) if other eight-related risk factors are present (dyslipidaemias, diabetes mellitus). In those patients with an inadequate response on initial dose of 10 mg per day (suggested as less than 2 kg weight loss in four weeks), the dose may be increased to 15 mg once daily, providing that sibutramine is well tolerated. Several large-scale randomized clinical trials demonstrated the efficacy of long-term (at least one year) treatment with sibutramine in obese subjects with or without type 2 diabetes. Sibutramine was also shown to help in maintaining long-term weight reduction. Most frequent side-effects are dry mouth and constipation, as well as mild increase in heart rate and arterial blood pressure. The impact of sibutramine on cardiovascular morbidity and mortality of obese nondiabetic and diabetic patients will be studied soon in a large international prospective clinical trial. [less ▲]Detailed reference viewed: 84 (2 ULg) Isokinetic evaluation of hip strength muscle groups in unilateral lower limb amputeesCroisier, Jean-Louis ; Maertens De Noordhout, Benoît ; Maquet, Didier et alin Isokinetics & Exercise Science (2001), 9(4), 163-169The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order ... [more ▼]The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order to improve the usual rehabilitation programs. Thirty-three patients with unilateral lower limb amputation were included in this study; they served as their own controls, the amputated side being compared to the intact side. Using an isokinetic device, the relative peak torques (N.m by body weight), bilateral asymmetries and agonist/antagonist torque ratios were calculated for the hip flexor, extensor, adductor and abductor muscle groups. A significant reduction of mean concentric relative peak torque measured on the amputated limbs was generally observed when compared to the intact contralateral limb (p < 0.05). The mean percentage of relative peak torque decrease was greater for the extensors than for the flexors (33 +/- 20% and 22 +/- 23%, respectively, at 30degrees/s angular velocity), and for the abductors than for the adductors (23 +/- 22% and 11 +/- 19%, respectively, at 30degrees/s angular velocity). Furthermore, the flexor/extensor torque ratio was significantly increased for the amputated limb (for instance, 1.25 +/- 0.33 versus 1.09 +/- 0.25 for the intact limb at 30degrees/s). The reduction of the abductor/adductor ratio of the operated limb reached the level of statistical significance at 60degrees/s only (1.25 +/- 0.46 versus 1.07 +/- 0.36 for the intact limb). In conclusion, isokinetic testing revealed a significant reduction of the hip stabilizing muscle strength as a consequence of lower limb amputation. The more marked decrease of the strength of the abductor and extensor muscle groups, resulting in imbalances of the agonist/antagonist strength ratios should be taken into account to adapt the conventional rehabilitation programs. [less ▲]Detailed reference viewed: 241 (12 ULg) Pex, Analytical Tools For Pdb Files. II. H-Pex: Noncanonical H-Bonds In Alpha-HelicesThomas, Annick ; Benhabiles, N.; Meurisse, R. et alin Proteins-Structure Function and Genetics (2001), 43(1), 37-44We use the H-Pex (Thomas et al., this issue) to analyze the main chain interactions in 131 proteins. In antiparallel beta-sheets, the geometry of the N...O bond is: median N...O distances, 2.9 SA, C==O ... [more ▼]We use the H-Pex (Thomas et al., this issue) to analyze the main chain interactions in 131 proteins. In antiparallel beta-sheets, the geometry of the N...O bond is: median N...O distances, 2.9 SA, C==O...N angles at 154 degrees and the C alpha--C==O...H angles are dispersed around 3 degrees. In some instances, the other side of the C==O axis is occupied by a HC alpha. As recently supported by Vargas et al. (J Am Chem Soc 2000;122:4750-4755) C alpha H...O and NH...O could cooperate to sheet stability. In alpha-helices, the main chain C==O interact with the NH of their n + 4 neighbor on one side, and with a C beta H or C gamma H on the other side. The median O...N distance (3.0 A) and C==N angle (147 degrees) suggest a canonical H-bond, but the C alpha--C==O...H dihedral angle invalidates this option, since the hydrogen attacks the oxygen at 122 degrees, i.e., between the sp(2) and pi orbitals. This supports that the H-bond is noncanonical. In many instances, the C gamma H or the C beta H of the n + 4 residue stands opposite to the NH with respect to the oxygen. Therefore, we propose that, in alpha-helices, the C gamma H or C beta H and the NH of the n + 4 residue hold the oxygen like an electrostatic pincher. [less ▲]Detailed reference viewed: 9 (0 ULg) The effect of risedronate on hip fracture risk in elderly women with osteoporosisBensen, W; Eastell, R; Reginster, Jean-Yves et alin Journal of Rheumatology (2001), 28(S63), 24Detailed reference viewed: 4 (1 ULg) CommentaireRichelle, Marc in Intellectica (2001), 33Detailed reference viewed: 19 (0 ULg) B2 agonists cross the bovine placentaBoutet, Philippe ; Uysterpruyst, C. H.; Degand, Guy et alin Pflügers Archiv : European Journal of Physiology (2001), 442(R41), Detailed reference viewed: 17 (0 ULg) Construire des indicateurs internationaux d'équité des systèmes éducatifsDemeuse, Marc ; Baye, Ariane ; Straeten, Marie-Hélène et alin Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 97-100Les membres du SPE se préoccupent de longue date des problèmes d'équité éducative (Crahay, 2000). Ils contribuent soit à l'évaluation de celle-ci dans le système belge francophone ou au sein d'autres ... [more ▼]Les membres du SPE se préoccupent de longue date des problèmes d'équité éducative (Crahay, 2000). Ils contribuent soit à l'évaluation de celle-ci dans le système belge francophone ou au sein d'autres systèmes à travers des recherches internationales, telles celles de l'IEA ou de l'OCDE (Demeuse, Crahay [less ▲]Detailed reference viewed: 56 (6 ULg) Elaboration d'une batterie d'évaluation des fonctions cognitives de sujets âgés porteurs d'un syndrome de DownGeorges, M.; Théwis, B.; Van der Linden, Martial et alin Revue de Neuropsychologie (2001), 11Detailed reference viewed: 35 (2 ULg) Actualites therapeutiques 2001.Scheen, André in Revue Médicale de Liège (2001), 56(9), 612-24The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule as ... [more ▼]The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule as well as its modalities of appropriate use in clinical practice will be pointed out. [less ▲]Detailed reference viewed: 5 (0 ULg) Analysis Of The Chromosome Sequence Of The Legume Symbiont Sinorhizobium Meliloti Strain 1021Capela, Delphine; Barloy-Hubler, Frédérique; Gouzy, Jérôme et alin Proceedings of the National Academy of Sciences of the United States of America (2001), 98(17), Detailed reference viewed: 11 (1 ULg) Dose-dependent caffeine-induced conditioned locomotion in micePirona, Alexandre; Ferrara, André Onofrio; Tirelli, Ezio in Behavioural Pharmacology (2001), 12Detailed reference viewed: 23 (3 ULg) Life-cycle modelling of bequests and its implications for annuity valuationJousten, Alain in Journal of Public Economics (2001), 79In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes ... [more ▼]In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes.We find that consumption is non-increasing in the linear bequest parameter for the simplest certainty case, but that the same is not true for life-span uncertainty. Second, we study the issue of annuity valuation. For a sufficiently strong bequest motive, the true value of an annuity is equal to the actuarial value. This invalidates a previous claim that, for imperfect annuity markets, it is close to the simple financial value. [less ▲]Detailed reference viewed: 39 (8 ULg) Diagnosis of vertical velocities with the QG Omega equation: a relocation method to obtain pseudo-synoptic data setsRixen, Michel; Beckers, Jean-Marie ; Allen, J. T.in Deep-Sea Research Part I, Oceanographic Research Papers (2001), 48(6), 1347-1373The quantification of vertical motion and vertical fluxes is essential in our ability to predict and tolerate climate change. However, diagnostic estimations might be affected by the errors arising from ... [more ▼]The quantification of vertical motion and vertical fluxes is essential in our ability to predict and tolerate climate change. However, diagnostic estimations might be affected by the errors arising from the necessary compromise between spatio-temporal resolution and cost of hydrographic surveys. Observations of a numerical ocean model have been made in order to test the accuracy of different sampling strategies and their possible a-posteriori corrections. A simple first-order correction method, computing a pseudo-synoptic data set from a non-synoptic data set and involving a geostrophic relocation of the stations is shown to correct significantly the synopticity error in hydrographic data, derived QG vertical motion and vertical temperature fluxes. Sensitivity analyses also show that the lack of synopticity is more critical than other factors, including the sampling resolution, the level of no-motion and the analysis. (C) 2001 Elsevier Science Ltd. All rights reserved. [less ▲]Detailed reference viewed: 45 (8 ULg) Formation des enseignants de français et compétences de communicationDumortier, Jean-Louis in Puzzle (2001), 10Detailed reference viewed: 89 (4 ULg) Rappresentazioni e pratiche Alimentari in Adolescenza. I risultati preliminari di un’analisi del contenuto delle Interviste semistrutturate con il Programma AlcesteD'Amore, Salvatore in Eating and Weight Disorders [=EWD] (2001), 6(2), 15Many studies have analysed psychopathological dimensions of relationship that adolescent have with food and body. But few researches have focused attention on links between psychosocial dimensions such as ... [more ▼]Many studies have analysed psychopathological dimensions of relationship that adolescent have with food and body. But few researches have focused attention on links between psychosocial dimensions such as social representations (Moscovici, S. 1961; Lalhou, S.1995) and adolescent typical practices of eating (with family and peers) and body (diet and sport). This research is aimed to describe and to analyse representations and practices of eating and body of 60 adolescents (30 females, 30 males) equally distributed on high and low social class aged from 14 to 16 years. Hypothesis supposes changes of eating and body representations and practices according to sexe and social class of subjects. A multimethodogical approach was adopted. Data were collected in Avril 1999 in two roman colleges. Qualitative and quantitative instruments were administered in this order: a) associative network (words association), b) semi-structured interviews (18 questions about eating and body ideas and practices), c) body drawing, d) eating family drawing, e) questionnaires (Eating Attitudes Test, Eating Disorders Inventory 2). A preliminary interviews content analysis with ALCESTE (Reinert, M.1993) draw out 8 discourse classes. Four classes are linked to eating representations and practices: a) Eating Family Practice (16,85 %); b) Eating with Friends (8, 61%); c) Eating quantity and preferences (15, 97%); d) Daily meals organisation (7,40%). Others four classes are linked to body representations and practices: e) Eating Problems (20, 13%); f) Body Health and beauty (8,07%); g) Diets and Sports ( 10,86%); h) Food quality (12, 10%). Results show a general picture of eating and body representations and practices. Eating with family is a very important social situation: a script characterised by social actors, rules, actions and contexts is outlined. Food intake control and food preferences seem pregnant dimensions in identity construction process face to family and peers. Naive theories about eating disorders are constructed. Finally diet, sport and food quality seem central in shaping and modelling body. [less ▲]Detailed reference viewed: 63 (2 ULg) Le rôle fédérateur d'un architecte. Entretien avec Claude Strebelle.Frankignoulle, Pierre in A+ (2001)Detailed reference viewed: 43 (8 ULg) Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs.Moreaux, B.; Advenier, C.; Gustin, Pascal in Fundamental & Clinical Pharmacology (2001), 15(1), 23-29Angiotensin-converting enzyme (ACE) inhibitors are among the first-choice drugs for treating hypertension and congestive heart disease. It has been reported, however, that these drugs could induce chronic ... [more ▼]Angiotensin-converting enzyme (ACE) inhibitors are among the first-choice drugs for treating hypertension and congestive heart disease. It has been reported, however, that these drugs could induce chronic cough and airway hyperresponsiveness. The aim of this work was to assess in pigs the effects of bradykinin and tachykinins on citric-acid-induced coughing after ACE inhibitor pretreatment. Coughing was induced by challenging pigs with an aerosol of 0.8 M citric acid over 15 min. Coughs were counted by a trained observer for 30 min. The animals underwent two cough induction tests two days apart (days 1 and 3), the first being taken as a control. All drugs were injected intravenously 30 min before the second challenge. In the control group, no difference was observed between days 1 and 3. The ACE inhibitor enalapril (7.5 and 15 microg/kg) caused the cough frequency to increase significantly. In contrast, a dose-related decrease was observed with Hoe140 (icatibant), a bradykinin B2 receptor antagonist (0.5 and 1 mg/kg). When both drugs were administered simultaneously (15 microg/kg for enalapril and 1 mg/kg for Hoe140), a significant increase was observed as compared with the control value obtained on day 1. When enalapril was combined with the three tachykinin receptor antagonists SR 140333 (NK1 receptor antagonist), SR 48968 (NK2 receptor antagonist) and SR 142801 (NK3 receptor antagonist), a significant decrease was observed as compared with control value obtained on day 1; the percentage of variation was also significantly different as compared with those observed in enalapril groups at both doses. These data suggest that ACE-inhibitor-induced enhancement of the cough reflex is mainly due to tachykinins and not to bradykinin in our pig model. Bradykinin, however, plays a major role in coughing induced by citric acid alone. [less ▲]Detailed reference viewed: 28 (1 ULg) On the influence of aluminium content on the stability of retained austenite in multiphase TRIP-assisted steelsMertens, Anne ; Jacques, Pascal J.; Lazarova, Roumiana et alin Journal de Physique IV (2001), 11Detailed reference viewed: 38 (2 ULg) Irreversible magnetization under rotating fields and lock-in effect on a ErBa2Cu3O7-delta single crystal with columnar defectsAvila, M. A.; Civale, L.; Silhanek, Alejandro et alin Physical Review. B : Condensed Matter (2001), 64(14), We have measured the irreversible magnetization (M-i) of an ErBa2Cu3O7-delta single crystal with columnar defects (CD), using a technique based on sample rotation under a fixed magnetic field H. This ... [more ▼]We have measured the irreversible magnetization (M-i) of an ErBa2Cu3O7-delta single crystal with columnar defects (CD), using a technique based on sample rotation under a fixed magnetic field H. This method is valid for samples whose magnetization vector remains perpendicular to the sample surface over a wide angle range-which is the case for platelets and thin films-and presents several advantages over measurements of M-L(H) loops at fixed angles. The resulting M-i(Theta) curves for several temperatures show a peak in the CD direction at high fields. At lower fields, a very well defined plateau indicative of the vortex lock-in to the CD develops. The H dependence of the lock-in angle phi (L) follows the H-1 theoretical prediction, while the temperature dependence is in agreement with entropic smearing effects corresponding to long range vortex-defects interactions. [less ▲]Detailed reference viewed: 9 (1 ULg) The Immuno-Inflammatory Reaction in Crohn's Disease and Ulcerative Colitis: Characterisation, Genetics and Clinical Application. Focus on Tnf AlphaLouis, Edouard in Acta Gastro-Enterologica Belgica (2001), 64(1), 1-5Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-inflammatory reaction, on genetic predisposition and on potential ... [more ▼]Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-inflammatory reaction, on genetic predisposition and on potential clinical application of blood immuno-inflammatory markers in these diseases. This paper summarizes some aspects of this work, focusing on TNF. Following points are developed: production of TNF by inflamed mucosa, genetic control of TNF production, TNF gene polymorphim in inflammatory bowel disease, and evaluation of serum TNF as a marker of disease activity or evolutivity. [less ▲]Detailed reference viewed: 20 (4 ULg) The Rain in Spain: Report on the Salamanca American Poetry ConferenceDelville, Michel ; Dworkinin Jacket (2001)Detailed reference viewed: 11 (0 ULg) Le travailleur adoptantKefer, Fabienne ; Barth, D.in Actualités du Droit (2001)Detailed reference viewed: 9 (0 ULg) Cutaneous Melanoma and the Mosan Study Group of Pigmented Tumors. A Step Forward to Trace Invisible Skin Cancers and to Offer Better TreatmentsPierard, Gérald ; Pierard-Franchimont, Claudine ; Claessens, N. et alin Revue Médicale de Liège (2001), 56(Suppl), 1-6Detailed reference viewed: 9 (0 ULg) Spécificités de la fonction cardiorespiratoire de l'âne (Equus asinus)Delvaux, Véronique ; Kirschvink, Nathalie; Amory, Hélène et alin Pratique Vétérinaire Equine (2001), 33(129), 21-28A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For ... [more ▼]A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For particular tests (haematology, measurement of arterial blond gases, electrocardiogram with phonocardiogram and thoracic radiographs, cardias echography), no major differences were found. However, the mechanical ventilation parameters differed from those for horses and moere similar to Chose for food-producing animais (carde): a higher resistance, a lower compliance and a higher maximum pleural pressure variation moere found. The "respiratory strategy" adopted by certain donkeys is different from that of horses: there are two to three phases of inspiration with a nil airflow between each phase. Expiration is the same as for horses. The conformation of the pharynx and larynx is slightly different to that of horses making it more difficult to pass an endoscope through this area. The lower respiratory tract is sensitive and it is necessary to apply a local anaesthetic (xylocaine) for this examination. The différential leukocyte count from tracheal lavage includes a number of epithelial cells, and a higher percentage of eosinophils and neutrophile for donkeys compared to horses. These similarities and différences between donkeys and horses should be taken into account when performing ancillary tests [less ▲]Detailed reference viewed: 222 (5 ULg) Optimisation and Use of Tandem-in-Time Mass Spectrometry in Comparison with Immunoassay and Hrgc/Hrms for Pcdd/F ScreeningFocant, Jean-François ; Eppe, Gauthier ; De Pauw, Edwin in Chemosphere (2001), 43(4-7, May-Jun), 417-24Rapid screening of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans using quadrupole ion storage tandem-in-time mass spectrometry (QISTMS) conjointly with polyclonal antibody ... [more ▼]Rapid screening of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans using quadrupole ion storage tandem-in-time mass spectrometry (QISTMS) conjointly with polyclonal antibody immunoassay has been considered. The optimisation of the fragmentation of the parent ion in the trap has been completed. The analysis of fly ashes from a municipal waste incinerator contaminated at different levels has then been realised. Results obtained using QISTMS, HRMS and immunoassay are compared. [less ▲]Detailed reference viewed: 14 (1 ULg) Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet.Biemar, F.; Argenton, F.; Schmidtke, R. et alin Developmental Biology (2001), 230(2), 189-203To begin to understand pancreas development and the control of endocrine lineage formation in zebrafish, we have examined the expression pattern of several genes shown to act in vertebrate pancreatic ... [more ▼]To begin to understand pancreas development and the control of endocrine lineage formation in zebrafish, we have examined the expression pattern of several genes shown to act in vertebrate pancreatic development: pdx-1, insulin (W. M. Milewski et al., 1998, Endocrinology 139, 1440-1449), glucagon, somatostatin (F. Argenton et al., 1999, Mech. Dev. 87, 217-221), islet-1 (Korzh et al., 1993, Development 118, 417-425), nkx2.2 (Barth and Wilson, 1995, Development 121, 1755-1768), and pax6.2 (Nornes et al., 1998, Mech. Dev. 77, 185-196). To determine the spatial relationship between the exocrine and the endocrine compartments, we have cloned the zebrafish trypsin gene, a digestive enzyme expressed in differentiated pancreatic exocrine cells. We found expression of all these genes in the developing pancreas throughout organogenesis. Endocrine cells first appear in a scattered fashion in two bilateral rows close to the midline during mid-somitogenesis and converge during late-somitogenesis to form a single islet dorsal to the nascent duodenum. We have examined development of the endocrine lineage in a number of previously described zebrafish mutations. Deletion of chordamesoderm in floating head (Xnot homolog) mutants reduces islet formation to small remnants, but does not delete the pancreas, indicating that notochord is involved in proper pancreas development, but not required for differentiation of pancreatic cell fates. In the absence of knypek gene function, which is involved in convergence movements, the bilateral endocrine primordia do not merge. Presence of trunk paraxial mesoderm also appears to be instrumental for convergence since the bilateral endocrine primordia do not merge in spadetail mutants. We discuss our findings on zebrafish pancreatogenesis in the light of evolution of the pancreas in chordates. [less ▲]Detailed reference viewed: 40 (0 ULg) L'exercice physique pour prevenir l'obesite, favoriser l'amaigrissement et maintenir la perte ponderale.Scheen, André ; Rorive, Marcelle ; Letiexhe, Michel in Revue Médicale de Liège (2001), 56(4), 244-7Obesity is a multifactorial disease making difficult the determination of the precise role of one specific factor such as physical activity or sedentary. Nevertheless, numerous arguments, derived from ... [more ▼]Obesity is a multifactorial disease making difficult the determination of the precise role of one specific factor such as physical activity or sedentary. Nevertheless, numerous arguments, derived from epidemiological observational studies or from randomized controlled interventional trials, support a favourable role of regular physical activity in the control of body weight. Physical activity contributes to prevent the occurrence of weight excess, especially in children or adolescents, to obtain a satisfactory weight loss, in general in combination with reduced-energy diets, and to maintain long-term weight loss. In addition, physical activity improves both the metabolic profile and health of obese subjects. [less ▲]Detailed reference viewed: 68 (3 ULg) Transfer of Tilapia (Oreochromis niloticus) to a hyperosmotic environment is associated with sustained expression of prolactin receptor in intestine, gill and kidneySandra, O.; Le Rouzic, P.; Rentier-Delrue, Françoise et alin General and Comparative Endocrinology (2001)Expression of tilapia prolactin receptor (tiPRL-R) has been characterised in the intestine, gill and kidney of tilapia species Oreochromis niloticus and the levels of both tiPRL-R transcripts and tiPRL ... [more ▼]Expression of tilapia prolactin receptor (tiPRL-R) has been characterised in the intestine, gill and kidney of tilapia species Oreochromis niloticus and the levels of both tiPRL-R transcripts and tiPRL binding sites have been analysed in these organs during adaptation tilapia to a hyperosmotic environment. [less ▲]Detailed reference viewed: 15 (2 ULg) Mass transfer in low-density xerogel catalystsHeinrichs, Benoît ; Pirard, Jean-Paul ; Schoebrechts, Jean-Paulin AIChE Journal (2001), 47(8), 1866-1873Texture and morphology of a Pd-Ag/SiO2 hydrodechlorination low-density xerogel catalyst prepared by a cogelation sot-gel process were characterized in detail to examine mass transfer in such catalysts ... [more ▼]Texture and morphology of a Pd-Ag/SiO2 hydrodechlorination low-density xerogel catalyst prepared by a cogelation sot-gel process were characterized in detail to examine mass transfer in such catalysts. The catalyst consists of active Pd-Ag nanocrystallites trapped inside elementary 20 nm microporous silica particles arranged in larger aggregates, which constitute the macroscopic pellet. To reach active sites, reactants must first diffuse through large pores located between aggregates of SiO2 Particles and then through smaller pores located between those elementary particles inside the aggregates. Finally, they, diffuse through micropores located inside silica particles. Diffusion in such a "funnel" structure cannot be described assimilating the pellet to a pseudo-continuum. Diffusion should be examined carefully at three levels of decreasing size: the macroscopic pellet, the aggregate of silica particles, and the elementary silica particle. This approach shows that cogelled xerogel catalysts have remarkable mass-transfer properties. [less ▲]Detailed reference viewed: 22 (7 ULg) Pharmacology of the Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor Bm-531Dogné, J. M.; Rolin, S.; de Leval, X. et alin Cardiovascular Drug Reviews (2001), 19(2, Summer), 87-96BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its ... [more ▼]BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its affinity for human washed platelet TXA2 receptors labeled with [3H]SQ-29548 (IC50 = 0.0078 microM) is higher than sulotroban (IC50 = 0.93 microM) and SQ-29548 (IC50 = 0.021 microM). Moreover, BM-531 is characterized by a potent antiaggregatory property. Indeed, on one hand, in human citrated platelet-rich plasma BM-531 prevents platelet aggregation induced by arachidonic acid (600 microM) (ED100 = 0.125 microM), U-46619, a stable TXA2 agonist (1 microM) (ED50 = 0.482 microM) or collagen (1 microgram/mL) (percentage of inhibition: 42.9% at 10 microM) and inhibits the second wave of ADP (2 microM)-induced aggregation. On the other hand, when BM-531 is incubated in whole blood from healthy donors, the closure time measured by the recently developed platelet function analyser (PFA-100) is significantly prolonged. In addition, at the concentrations of 10 and 1 microM, BM-531 totally prevents the production of TXB2 by human platelets activated by arachidonic acid. Finally, at 10 microM, BM-531 significantly prevents rat fundus contractions induced by U-46619 but not by prostacyclin. These results suggest that BM-531, which is devoid of the diuretic property of torasemide, can be regarded as a promising antiplatelet agent. [less ▲]Detailed reference viewed: 15 (0 ULg) Smectite composition as a tracer of deep circulation: the case of the Northern North AtlanticFagel, Nathalie ; Robert, Christian; Preda, Michel et alin Marine Geology (2001), 172(3-4), 309-330The link between smectite composition in sediments from the northern North Atlantic and Labrador Sea, and deep circulation is being further investigated through detailed studies of the X-ray pattern of ... [more ▼]The link between smectite composition in sediments from the northern North Atlantic and Labrador Sea, and deep circulation is being further investigated through detailed studies of the X-ray pattern of smectites and cation saturations. This allows clear distinction of dominant terrigenous sources associated to the main components of the modern Western Boundary Undercurrent. Time variations of smectite characteristics in two piston cores from the inlet and outlet of the Western Boundary Undercurrent gyre in the Labrador Sea indicate: (1) a more southern circulation of North East Atlantic Deep Water during the Late Glacial; (2) a step by step transition to the modern pattern of deep circulation during the Late Glacial/Holocene transition, with intensification of North East Atlantic Deep Water and Davis Strait Overflow; (3) an expansion of Davis Strait Overflow and Labrador Sea Water circulation in relation to ice surges and deposition of detrital layers; (4) an intensified circulation of North East Atlantic Deep Water during the Younger Dryas; and (5) a very recent increased influence of Denmark Strait Overflow Water beginning between 4.4 and <1 kyr. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]Detailed reference viewed: 40 (5 ULg) Varicella-Zoster virus gene expression in latently infected rat dorsal root ganglia.Kennedy, P. G.; Grinfeld, E.; Bontems, Sébastien et alin Virology (2001), 289(2), 218-23Latent infection of human ganglia with Varicella-Zoster virus (VZV) is characterized by a highly restricted pattern of viral gene expression. To enhance understanding of this process we used in situ ... [more ▼]Latent infection of human ganglia with Varicella-Zoster virus (VZV) is characterized by a highly restricted pattern of viral gene expression. To enhance understanding of this process we used in situ hybridization (ISH) in a rat model of VZV latency to examine expression of RNA corresponding to eight different VZV genes in rat dorsal root ganglia (DRG) at various times after footpad inoculation with wild-type VZV. PCR in situ amplification was also used to determine the cell specificity of latent VZV DNA. It was found that the pattern of viral gene expression at 1 week after infection was different from that observed at the later times of 1 and 18 months after infection. Whereas multiple genes were expressed at 1 week after infection, gene expression was restricted at the later time points when latency had been established. At the later time points after infection the RNA transcripts expressed most frequently were those for VZV genes 21, 62, and 63. Gene 63 was expressed more than any other gene studied. While VZV DNA was detected almost exclusively in 5-10% of neurons, VZV RNA was detected in both neurons and nonneuronal cells at an approximate ratio of 3:1. A newly described monoclonal antibody to VZV gene 63-encoded protein was used to detect this protein in neuronal nuclei and cytoplasm in almost half of the DRG studied. These results demonstrate that (1) this rat model of latency has close similarities in terms of viral gene expression to human VZV latency which makes it a useful tool for studying this process and its experimental modulation and (2) expression of VZV gene 63 appears to be the single most consistent feature of VZV latency. [less ▲]Detailed reference viewed: 22 (1 ULg) Comment j'explore ... une myopathie par biopsie musculaireDeprez, Manuel in Revue Médicale de Liège (2001), 56(1), 49-52Muscle biopsy is a valuable tool in the diagnosis of many neuromuscular disorders. It is an invasive investigation that will be considered after careful clinical examination, supplemented by biological ... [more ▼]Muscle biopsy is a valuable tool in the diagnosis of many neuromuscular disorders. It is an invasive investigation that will be considered after careful clinical examination, supplemented by biological and electrophysiological studies. The biopsy procedure and the subsequent processing of specimen in the laboratory significantly influence the information provided by the microscopic examination of muscle tissue. They are reviewed in details in this article. Close collaboration between clinicians and neuropathologists in the setting of an optimized procedure will further increase the diagnostic yield of muscle biopsy. [less ▲]Detailed reference viewed: 64 (8 ULg) The karyotype of the Formentera island garden dormouse, Eliomys quercinus ophiusaeRamalhinho, Graça; Libois, Roland in Belgian Journal of Zoology (2001), 131(1), 83-85Detailed reference viewed: 29 (2 ULg) Numeration systems on a regular language : Arithmetic operations, Recognizability and Formal power seriesRigo, Michel in Theoretical Computer Science (2001), 269Generalizations of numeration systems in which $$\N$$ is recognizable by a finite automaton are obtained by describing a lexicographically ordered infinite regular language $$L\subset \Sigma^*$$. For ... [more ▼]Generalizations of numeration systems in which $$\N$$ is recognizable by a finite automaton are obtained by describing a lexicographically ordered infinite regular language $$L\subset \Sigma^*$$. For these systems, we obtain a characterization of recognizable sets of integers in terms of $\N$-rational formal series. After a study of the polynomial regular languages, we show that, if the complexity of $$L$$ is $$\Theta (n^l)$$ (resp. if $$L$$ is the complement of a polynomial language), then multiplication by $$\lambda\in \N$$ preserves recognizability only if $$\lambda=\beta^{l+1}$$ (resp. if $$\lambda\neq (\#\Sigma)^\beta$$) for some $$\beta\in \N$$. Finally, we obtain sufficient conditions for the notions of recognizability for abstract systems and some positional number systems to be equivalent. [less ▲]Detailed reference viewed: 29 (2 ULg) Large-Scale Phenotypic Analysis Reveals Identical Contributions To Cell Functions Of Known And Unknown Yeast GenesBianchi, Mm.; Ngo, S.; Vandenbol, Micheline et alin Yeast (2001), 18(15), Detailed reference viewed: 12 (0 ULg) Increased Camp Levels and Protein Kinase (Pka) Type I Activation in Cd4+ T Cells and B Cells Contribute to Retrovirus-Induced Immunodeficiency of Mice (Maids): A Useful in Vivo Model for Drug TestingRahmouni, Souad ; Aandahl, Einar Martin; Trebak, Mohamed et alin FASEB Journal (2001), 15(8), 1466-1468Murine AIDS (MAIDS) is characterized by a lymphoproliferative disease and a profound anergy, which involves mostly CD4(+) T cells. To better define the mechanisms responsible for anergy, we measured cAMP ... [more ▼]Murine AIDS (MAIDS) is characterized by a lymphoproliferative disease and a profound anergy, which involves mostly CD4(+) T cells. To better define the mechanisms responsible for anergy, we measured cAMP concentrations in the different lymphocyte subsets of the infected mice. CD4(+) T cells and B cells displayed a dramatic 10- to 30-fold increase of cAMP. cAMP was also significantly increased in CD8(+) T cells, although to a far lesser extent. The unusual CD4(+) CD90(-) T cells, typical of MAIDS, were characterized by a much higher cAMP level than their CD90(+) counterparts. T cells of the infected mice were much more sensitive to inhibition by the cAMP analogue 8-CPT-cAMP, which confirmed increased in vivo exposure to cAMP. In accordance with the increased cAMP levels, PKA type I was constitutively activated and its C subunit was translocated to the nucleus. Finally, the profound T-cell anergy associated with MAIDS could be reversed by treating T cells with a PKA type I-selective antagonist ex vivo. MAIDS could constitute a suitable model for the study of new pharmacological agents aimed at reversing the immunosuppressive effects of cAMP previously shown to be involved in several pathological states, including HIV infection and common variable immunodeficiency. [less ▲]Detailed reference viewed: 44 (7 ULg) Size dependence of interior-to-edge ratios: size predominates shape.Bogaert, Jan in Acta Biotheoretica (2001), 49(2), 121-123Detailed reference viewed: 8 (0 ULg) Numerations systems on a regular languageLecomte, Pierre ; Rigo, Michel in Theory of Computing Systems (2001), 34Generalizations of positional number systems in which N is recognizable by finite automata are obtained by describing an arbitrary infinite regular language according to the lexicographic ordering. For ... [more ▼]Generalizations of positional number systems in which N is recognizable by finite automata are obtained by describing an arbitrary infinite regular language according to the lexicographic ordering. For these systems of numeration, we show that ultimately periodic sets are recognizable. We also study translation and multiplication by constants as well as the order-dependence of the recognizability. [less ▲]Detailed reference viewed: 38 (2 ULg) Land-cover change: quantification metrics for perforation using 2-D gap features.Bogaert, Jan ; Salvador-Van Eysenrode, D; Van Hecke, P et alin Acta Biotheoretica (2001), 49(3), 161-169Detailed reference viewed: 12 (0 ULg) Pictures in cell biology. Spatial dynamics of rRNAs.Thiry, Marc ; Cheutin, T.; O'Donohue, M. F. et alin Trends in Cell Biology (2001), 11(4), 147Detailed reference viewed: 9 (0 ULg) Acquisition of a novel vocabulary in an amnesic patientVan der Linden, Martial ; Cornil, Valérie; Meulemans, Thierry et alin Neurocase : Case Studies in Neuropsychology, Neuropsychiatry & Behavioural Neurology (2001), 7(4), 283-293This study explored the ability of a severe amnesic patient (AC) to acquire new vocabulary words. We compared AC's knowledge of words entered into the French lexicon during three different periods: before ... [more ▼]This study explored the ability of a severe amnesic patient (AC) to acquire new vocabulary words. We compared AC's knowledge of words entered into the French lexicon during three different periods: before 1920, between 1965 and 1985, and after 1986 (i.e. after the onset of his amnesia). AC's knowledge was assessed by asking him to give, for each word, its definition (word-definition task), the general domain Io which the word belonged ('domain' task), and to generate a sentence containing the word (sentence-generation task). Finally, we administered a recognition task in which AC had to select, for each word, its correct definition amongst four definitions. For all of these tasks, the results showed that AG's performance was similar to that of four control subjects matched for age, education, and profession. In particular, there was no difference with regard to AC's knowledge of words entered into the language after the onset of his amnesia. Therefore, these results indicate that, despite his profound amnesia, AC was able to learn normally new vocabulary words. More generally, they confirm that, at least is some cases, semantic learning can be spared in amnesia. [less ▲]Detailed reference viewed: 14 (4 ULg) A magnetic and conversion electron Mossbauer spectral study of amorphous Dy20Fe80-yCoy thin filmsFleury-Frenette, Karl ; Delwiche, Jacques ; Grandjean, Fernande et alin IEEE Transactions on Magnetics (2001), 37(4), 2311-2314Amorphous thin films of Dy20Fe80-yCoy, with 0 < y < 20 and of ca. 40 nm thickness, have been prepared by sputtering on polyimide substrates. The 295 K conversion electron Mossbauer spectra (CEMS) of these ... [more ▼]Amorphous thin films of Dy20Fe80-yCoy, with 0 < y < 20 and of ca. 40 nm thickness, have been prepared by sputtering on polyimide substrates. The 295 K conversion electron Mossbauer spectra (CEMS) of these films consist of broadened sextets which have been analyzed with a distribution of hyperfine fields in which the iron moments are oriented perpendicular to the plane of the film, an orientation which is in agreement with the perpendicular magnetic anisotropy observed herein at 295 K by vibrating sample magnetrometry. The average hyperfine field and isomer shift increase linearly with increasing Co content. Both increases arise from an increase in the electron occupation of the 3d states as the cobalt content increases. [less ▲]Detailed reference viewed: 42 (6 ULg) Principes et intérêts du simulateur en anesthésie-réanimationLarbuisson, Robert ; Nyssen, Anne-Sophie ; Janssens, Marc et alin Praticien en Anesthésie Réanimation (Le) (2001), 5(4), 225Detailed reference viewed: 44 (4 ULg) Off Shelf Fluxes of Labile Materials by an Upwelling Filament in the NW Iberian Upwelling SystemAlvarez-Salgado, Xosé Antón; Doval, M. D.; Borges, Alberto et alin Progress in Oceanography (2001), 50(2-4), 321-337Daily changes in the concentrations of carbon and nitrogen species were monitored during the course of a Lagrangian drifter experiment in a recurrent upwelling filament south of Cape Finisterre (NW ... [more ▼]Daily changes in the concentrations of carbon and nitrogen species were monitored during the course of a Lagrangian drifter experiment in a recurrent upwelling filament south of Cape Finisterre (NW Iberian Upwelling System). A drifting buoy released at the southern edge of the upwelling centre generated by the Cape moved 60km southwestwards from 3 to 7 August 1998. Organic matter in the 50m deep study water mass (average 77±2 μM C) consisted of: 57μM C of dissolved organic matter (DOM) with a C/N molar ratio of 19±2; 6μM C of DOM with a C/N ratio of 9±2, and 14μM C of 50% DOM and 50% suspended organic matter (POMsusp) with a C/N ratio of 6.0±0.4. Net conversion of consumed inorganic salts into accumulated TOM=POMsusp+DOM was 40% for nitrogen and 30% for carbon. Since the parcel of water crossed the shelf-edge, these conversion efficiencies are equivalent to net horizontal export-ratio of 0.4 and 0.3 respectively. A second drifter was deployed in the offshore-end of the filament, and was displaced 20km west between 14 and 17 August 1998. Nitrate was exhausted in the surface water and no significant changes were observed in the variables measured during the course of the second experiment. Low C/N ratios (6.5±0.4) and rapid POMsusp/DOM inter-conversion in the 20 μM C excess observed in the study volume points to the persistence of the labile materials formed on the shelf during transport to the ocean. Our data demonstrate a) the key role of upwelling filaments in off-shelf export of organic materials and b) the major contribution of DOM to this horizontal export, a previously unaccounted amount. [less ▲]Detailed reference viewed: 34 (7 ULg) Quantitative cell dispersion analysis: new test to measure tumor cell aggressivenessNawrocki-Raby, Béatrice; Polette, Myriam; Gilles, Christine et alin International Journal of Cancer = Journal International du Cancer (2001), 93(5), 644-52Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between ... [more ▼]Tumor progression requires the dispersion of epithelial cells from neoplastic clusters and cell invasion of adjacent stromal connective tissue. Aiming at demonstrating the precise relationships between cell dispersion and cell invasion, related respectively to expression of E-cadherin/catenin complex and matrix metalloproteinases (MMPs), we developed an original in vitro model of cell dispersion analysis. Our study reports the validation of this model that allowed us to analyze and quantify the cell cohesion level by means of time-lapse videomicroscopy and computer analysis based on the observation of spatial and temporal cell distribution. Our model was able to distinguish 2 groups among different human bronchial and mammary epithelial cells previously characterized for the expression of E-cadherin/catenin complex and MMPs and their invasive capacity in the Boyden chamber assay. The first group (16HBE14o-, MCF-7, T47D) that expressed membranous E-cadherin and -catenin, and was negative for MMP-2 expression and non-invasive, displayed a highly cohesive pattern corresponding to a cluster spatial distribution. The second group (Beas2B, BZR, BZR-T33, MDA-MB-231, MDA-MB-435, BT549 and HS578T) that was invasive and showed lack of expression of E-cadherin and a cytoplasmic redistribution of -catenin, displayed a dispersed pattern corresponding to a random spatial distribution. Downregulation of E-cadherin by a blocking antibody induced a more random distribution. Conversely, expression of E-cadherin by cDNA transfection induced a cluster distribution. Moreover, tumor cell lines that co-expressed MT1-MMP and MMP-2 (Beas2B, BZR, BZR-T33, MDA-MB-435, BT549 and HS578T) showed a more dispersed pattern than tumor cell lines that did not express MMP-2 (MDA-MB-231). In conclusion, we demonstrated that the spatial group behavior of cell lines, i.e., their cohesion/dispersion ability, reflects their invasive properties. Thus, this model of cell dispersion analysis may represent a new test to measure tumor cell aggressiveness. [less ▲]Detailed reference viewed: 50 (10 ULg) Supernumerary outer hair cells arise external to the last row of sensory cells in the organ of corti.Lefèbvre, Philippe ; Malgrange, Brigitte ; Thiry, Marc et alin Acta Oto-Laryngologica (2001), 121(2), 164-8During the development of the mammalian inner ear, the number of hair cells produced is highly regulated and remains constant throughout life. The mechanism underlying this regulation is beginning to be ... [more ▼]During the development of the mammalian inner ear, the number of hair cells produced is highly regulated and remains constant throughout life. The mechanism underlying this regulation is beginning to be understood although many aspects still remain obscure. When late embryonic or early postnatal rat organs of Corti were cultured, the production of supernumerary hair cells was observed. This overproduction of sensory cells could be modulated by the addition of several growth factors. In this study, we examined explants of rat organs of Corti that produced supernumerary hair cells. In the supernumerary hair cell region, up to two rows of inner hair cells and five rows of outer hair cells were observed. Morphological evaluation of these specimens revealed that less mature hair cells were located in the most external rows of these sensory cells. When a supernumerary hair cell was produced, a supporting cell (i.e. Deiters' cell) was also produced, strongly suggesting that the conversion of a Deiters' cell into a hair cell was not the mechanism that produced these extra hair cells. Based on these results, we propose that prosensory cells located at the external edge of the organ of Corti retain a capacity to form hair cells and that it is these prosensory cells that differentiate into supernumerary hair cells and Deiters' cells. [less ▲]Detailed reference viewed: 49 (9 ULg) Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES StudyReinhart, Konrad; Menges, Thilo; Gardlund, Bengt et alin Critical Care Medicine (2001), 29(4), 765-769Objective: This study investigated whether treatment with the anti-tumor necrosis factor-a monoclonal antibody afelimomab would improve survival in septic patients with serum interleukin (IL)-6 ... [more ▼]Objective: This study investigated whether treatment with the anti-tumor necrosis factor-a monoclonal antibody afelimomab would improve survival in septic patients with serum interleukin (IL)-6 concentrations of >1000 pg/mL. Design: Multicenter, double-blind, randomized, placebo-controlled study. Setting: Eighty-four intensive care units in academic medical centers in Europe and Israel. Patients: A total of 944 septic patients were screened and stratified by the results of a rapid qualitative immunostrip test for serum IL-6 concentrations. Patients with a positive test kit result indicating IL-6 concentrations of >1000 pg/mL were randomized to receive either afelimomab (n 5 224) or placebo (n 5 222). Patients with a negative IL-6 test (n 5 498) were not randomized and were followed up for 28 days. Interventions: Treatment consisted of 15-min infusions of 1 mg/kg afelimomab or matching placebo every 8 hrs for 3 days. Standard surgical and intensive care therapy was otherwise delivered. Measurements and Main Results: The study was terminated prematurely after an interim analysis estimated that the primary efficacy end points would not be met. The 28-day mortality rate in the nonrandomized patients (39.6%, 197 of 498) was significantly lower (p < .001) than that found in the randomized patients (55.8%, 249 of 446). The mortality rates in the IL-6 test kit positive patients randomized to afelimomab and placebo were similar, 54.0% (121 of 224) vs. 57.7% (128 of 222), respectively. Treatment with afelimomab was not associated with any particular adverse events. Conclusions: The IL-6 immunostrip test identified two distinct sepsis populations with significantly different mortality rates. A small (3.7%) absolute reduction in mortality rate was found in the afelimomab-treated patients. The treatment difference did not reach statistical significance. [less ▲]Detailed reference viewed: 28 (0 ULg) Compte-rendu de Bruce Bégout, La généalogie de la logique. Husserl, l'antéprédicatif et le catégorialLeclercq, Bruno in Recherches Husserliennes (2001), 16Detailed reference viewed: 136 (1 ULg) Spatial aggregation of two-dimensional objects in raster data structures.Bogaert, Jan ; Rousseau, Rin Applied Mathematics and Computation (2001), 119(2-3), 117-126Detailed reference viewed: 5 (1 ULg) Kenneth Koch, New AddressesDelville, Michel in Verse (2001)Detailed reference viewed: 21 (0 ULg) La réforme de la procédure fiscale : le point de vue de la Cour d’arbitrageOrban, Lionel in Fiscalité 2001. Le point sur les réformes », Journée d’études du Mercredi 31 octobre 2001, organisée par le Service de droit fiscal de la Faculté de droit de l’Université de Liège (2001)Detailed reference viewed: 27 (0 ULg) Voix de la mémoire et causes obscuresGauthier, Jean-Marie in Cahiers de Psychologie Clinique (2001), 16Freud a établi un lien très fort entre Inconscient et temporalité puisque, à l'inverse de toutes nos autres productions personnelles, seul celui-ci ne subirait pas les outrages du temps. Ce texte tente de ... [more ▼]Freud a établi un lien très fort entre Inconscient et temporalité puisque, à l'inverse de toutes nos autres productions personnelles, seul celui-ci ne subirait pas les outrages du temps. Ce texte tente de montrer l'importance et la richesse de cette intuition freudienne à travers l'analyse du film de W. Wenders, 'Lisbon Story'. Il nous faut alors, pour reprendre les propos de Freud constater que la structure de nos temporalités intérieures est complexe, à la fois immuable et en perpétuelle transformation. [less ▲]Detailed reference viewed: 34 (4 ULg) On Conducting Burden-of-Osteoporosis Studies: A Review of the Core Concepts and Practical Issues. A Study Carried out under the Auspices of a Who Collaborating CenterBen Sedrine, Wafa ; Radican, L.; Reginster, Jean-Yves in Rheumatology (2001), 40(1), 7-14Osteoporosis is a problem that is relevant to public health from the clinical, economic and social viewpoints. Except in a handful of industrialized countries, there is a considerable void in our ... [more ▼]Osteoporosis is a problem that is relevant to public health from the clinical, economic and social viewpoints. Except in a handful of industrialized countries, there is a considerable void in our knowledge of the magnitude of the problem. By exploring both the epidemiological and the economic impact of osteoporosis and the fractures associated with it in a particular country, studies of the 'burden of illness' (BOI) can fill that void. BOI analysis raises many questions at both the conceptual and the practical level. The purpose of this paper is to review the methodology underlying analyses of this type, to discuss its limitations and to provide a general format to improve their implementation in the field of osteoporosis. Investigators involved in BOI analysis should be very clear and explicit regarding the methods they adopt, so that studies in different countries can be interpreted and compared appropriately by interested parties. [less ▲]Detailed reference viewed: 83 (6 ULg) Spirometric performance in Belgian Blue calves: I. Effects on economic losses due to the bovine respiratory disease complex.Bureau, Fabrice ; Detilleux, Johann ; Dorts, T. et alin Journal of Animal Science (2001), 79(5), 1301-1304The aim of this study was to determine whether high spirometric performances in calves are associated with low economic losses due to the bovine respiratory disease complex (BRDC). Five spirometric ... [more ▼]The aim of this study was to determine whether high spirometric performances in calves are associated with low economic losses due to the bovine respiratory disease complex (BRDC). Five spirometric variables (SV) were measured in 909 double-muscled Belgian Blue calves from 15 to 60 d of age. Afterward, calves were monitored for 6 mo to determine whether they developed BRDC and to determine the costs due to BRDC (i.e., medicine costs and veterinarians' fees, plus estimated financial losses due to mortality in case of death). To analyze the effects of spirometric performances on BRDC cost, a fixed linear model was used for each SV. In addition to SV, each model included the effects of sex, dam's parity, vaccination status, muscular development score, herd-period, and BW. Only herd-period and the maximal ventilation and the vital capacity had significant effects on costs due to BRDC, indicating that these two SV are major physiological determinants of economic losses associated with BRDC. Accordingly, it is assumed that an amelioration of maximal ventilation and vital capacity could result in increased resistance to BRDC in calves. [less ▲]Detailed reference viewed: 27 (2 ULg) Orientation And Effects Of Mastoparan X On Phospholipid BicellesWhiles, Ja.; Brasseur, Robert ; Glover, Kj. et alin Biophysical Journal (2001), 80(1), 280-93Mastoparan X (MPX: INWKGIAAMAKKLL-NH2) belongs to a family of ionophoric peptides found in wasp venom. Upon binding to the membrane, MPX increases the cell's permeability to cations leading to a ... [more ▼]Mastoparan X (MPX: INWKGIAAMAKKLL-NH2) belongs to a family of ionophoric peptides found in wasp venom. Upon binding to the membrane, MPX increases the cell's permeability to cations leading to a disruption in the electrolyte balance and cell lysis. This process is thought to occur either through a membrane-thinning mechanism, where the peptide resides on the membrane surface thereby disrupting lipid packing, or through formation of an oligomeric pore. To address this issue, we have used both high-resolution and solid-state 2H NMR techniques to study the structure and orientation of MPX when associated with bicelles. NOESY and chemical shift analysis showed that in bicelles, MPX formed a well-structured amphipathic alpha-helix. In zwitterionic bicelles, the helical axis was found to rest generally perpendicular to the membrane normal, which could be consistent with the "carpet" mechanism for lytic activity. In anionic bicelles, on the other hand, the helical axis was generally parallel to the membrane normal, which is more consistent with the pore model for lytic activity. In addition, MPX caused significant disruption in lipid packing of the negatively charged phospholipids. Taken together, these results show that MPX associates differently with zwitterionic membranes, where it rests parallel to the surface, compared with negatively charged membranes, where it penetrates longitudinally. [less ▲]Detailed reference viewed: 12 (0 ULg) L'image du mois. L'hypotension orthostatique filmee par le Finapres: neuropathie autonome versus cause iatrogene.Scheen, André ; Descampheleire, M.; Marchand, Monique in Revue Médicale de Liège (2001), 56(3), 133-4Detailed reference viewed: 38 (0 ULg) Experimental M1 Transition Rates in Highly Charged Krypton IonsTräbert, E.; Beiersdorfer, P.; Brown, G. V. et alin Physical Review. A (2001), 64Detailed reference viewed: 14 (2 ULg) De l'"Etat social actif" à la politique belge de l'emploiMatagne, Geoffroy in Courrier Hebdomadaire du CRISP (2001), 1737-1738Detailed reference viewed: 204 (32 ULg) Deep dysphasia : Further evidence on the relationship between phonological short-term memory and language processing impairmentsMajerus, Steve ; Lekeu, Françoise ; Van der Linden, Martial et alin Cognitive Neuropsychology (2001), 18(5), 385-410We report a cognitive investigation of a case of deep dysphasia appearing in the context of primary progressive aphasia. Over a period of 5 years, patient CO presented progressive difficulties in word ... [more ▼]We report a cognitive investigation of a case of deep dysphasia appearing in the context of primary progressive aphasia. Over a period of 5 years, patient CO presented progressive difficulties in word finding and in oral comprehension, while nonverbal cognitive functions remained preserved. As in other deep dysphasic patients, CO's repetition performance showed marked imageability and lexicality effects, and semantic paraphasias. The same effects were observed in writing-to-dictation. Regularisation errors occurred in word reading. CO's short-term memory span was less than two words. A cognitive analysis of language processing revealed difficulties in phoneme identification and rhyme judgement, in detecting grammatical class for orally presented words, and in oral and written naming. The interpretation of CO's deep dysphasic symptoms within interactive models of language processing confirmed the importance of a phonological short-term storage impairment as an explanatory factor of deep dysphasia. [less ▲]Detailed reference viewed: 49 (10 ULg) Augmented Lagrangian procedure for implicit computation of contact-impact between deformable bodies.Graillet, D.; Ponthot, Jean-Philippe ; Stainier, Laurent in International Journal of Crashworthiness (2001), 6(2), 209-221This paper shows how efficiency can be improved by using an adequate Augmented Lagrangian procedure instead of the classical and well-known Penalty method for solving contact-impact problems between ... [more ▼]This paper shows how efficiency can be improved by using an adequate Augmented Lagrangian procedure instead of the classical and well-known Penalty method for solving contact-impact problems between deformable bodies, including frictional contact, large deformations, dynamical effects and inelasticity phenomena The Augmented Lagrangian method has already enjoyed great success in solving constrained minimisation problems or incompressibility conditions. Alternatives to existing automation techniques for augmentations are presented. Starting from a Penalty method, it will be seen how the Augmented Lagrangian decreases ill-conditioning of governing equations and gives a more precise solution with a lower CPU-cost. Several original simultaneous criteria are proposed for optimising the number and the location of the augmentations in an incremental implicit resolution. Application of the method is done for two axisymmetric impact problems. [less ▲]Detailed reference viewed: 59 (3 ULg) Is Aggregation Of Beta-Amyloid Peptides A Mis-Functioning Of A Current Interaction Process?Festy, F.; Lins, Laurence ; Peranzi, G. et alin Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology (2001), 1546(2), 356-64In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is ... [more ▼]In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is specific. They further supported that the method could be used to define the sequences that might be important in nucleation-dependent aggregation. The sequence of the amyloid peptide can be split into four clusters, two hydrophilic (1-16 and 22-28) and two hydrophobic (17-21 and 29-42). We designed by molecular modeling and tested by the two-hybrid approach, series of mutations spread all over the sequence and changing the distribution of hydrophobicity and/or the spatial hindrance. In the two-hybrid assay, interaction of native Abeta is reproduced. Screening of mutations demonstrates that the C-domain (residues 29-40 (42)), the median domain (residues 17-22) and the N-domain (1-16) are all crucial for interaction. This demonstrates that almost all fragments of the amyloid peptide but a loop (residues 23-28) and the C-term amino acid are important for the native interaction. We support that the folded three-dimensional (3D) structure is the Abeta-Abeta interacting species, that the whole sequence is involved in that 3D fold which has a low secondary structure propensity and a high susceptibility to mutations and thus should have a low stability. The native fold of Abeta could be stabilized in Abeta-Abeta complexes which could in other circumstances facilitate the nucleation event of aggregation that leads to the formation of stable senile plaques. [less ▲]Detailed reference viewed: 12 (0 ULg) Exercice physique et sport: du meilleur au pire.Scheen, André ; Kulbertus, Henri in Revue Médicale de Liège (2001), 56(4), 193-4Detailed reference viewed: 38 (1 ULg) Practical Aspects Of Computational Chemistry Calculations Through Pc Networks: The Ramses-Beowulf ImplementationBeuve-Mery, D.; Rahman, M.; Ducarme, P. et alin Journal of Computational Chemistry (2001), 22(2), 172-7We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our ... [more ▼]We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our experience and discuss our choices. The architecture is composed of Pentium processors connected by a 100 Mbits/s Ethernet network. Because RAMSES are built of independent computers, the system is easily maintained, and can be modified by adding or removing machines. Two programs, which are dedicated to molecular modeling and were previously developed on single machines (OSIRIS and IMPALA), have been adapted. IMPALA models peptide and protein interaction with membranes, OSIRIS simulates an ab initio folding of globular proteins. After parallelization, each program consists of two parts: one is the human/RAMSES interface, and the second is the simulation per se. The parallel architecture is transparent for the users. Tests of the IMPALA and OSIRIS efficiencies are shown and discussed. [less ▲]Detailed reference viewed: 23 (0 ULg) Criterii de differentiere a unor specii de VeronicaCrisan, Gianina; Tamas, M.; Garbacki, Nancy et alin Farmacia (2001), 49(6), 67-73We have tried to establish some criteria to avoid the substitution of Veronica officinalis L; with anti-ulcer and anti-inflammatory activities with other species of the genus Veronica, especially Veronica ... [more ▼]We have tried to establish some criteria to avoid the substitution of Veronica officinalis L; with anti-ulcer and anti-inflammatory activities with other species of the genus Veronica, especially Veronica chamaedrys L. widely spread and without therapeutic use. We have studied the different histological, anatomical and phytochemical characters for the two species. A rapid method for the identification of both species is the TLC for flavonoids and phenylpropanic compounds was described. Moreover HPLC is useful to detect the presence of acteoside only in Veronica chamaedrys, while Veronica officinalis contains isoacteoside. [less ▲]Detailed reference viewed: 79 (4 ULg) Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitroCalaora, Viviane; Rogister, Bernard ; Bismuth, Karen et alin Journal of Neuroscience (2001), 21Detailed reference viewed: 11 (1 ULg) Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: molecular basis of enzyme deficiencyOrosz, F.; Olah, J.; Alvarez, M. et alin Blood (2001), 98(10), 3106-12In a Hungarian family with severe decrease in triosephosphate isomerase (TPI) activity, 2 germ line-identical but phenotypically differing compound heterozygote brothers inherited 2 independent (Phe240Leu ... [more ▼]In a Hungarian family with severe decrease in triosephosphate isomerase (TPI) activity, 2 germ line-identical but phenotypically differing compound heterozygote brothers inherited 2 independent (Phe240Leu and Glu145stop codon) mutations. The kinetic, thermodynamic, and associative properties of the recombinant human wild-type and Phe240Leu mutant enzymes were compared with those of TPIs in normal and deficient erythrocyte hemolysates. The specific activity of the recombinant mutant enzyme relative to the wild type was much higher (30%) than expected from the activity (3%) measured in hemolysates. Enhanced attachment of mutant TPI to erythrocyte inside-out vesicles and to microtubules of brain cells was found when the binding was measured with TPIs in hemolysate. In contrast, there was no difference between the binding of the recombinant wild-type and Phe240Leu mutant enzymes. These findings suggest that the missense mutation by itself is not enough to explain the low catalytic activity and "stickiness" of mutant TPI observed in hemolysate. The activity of the mutant TPI is further reduced by its attachment to inside-out vesicles or microtubules. Comparative studies of the hemolysate from a British patient with Glu104Asp homozygosity and with the platelet lysates from the Hungarian family suggest that the microcompartmentation of TPI is not unique for the hemolysates from the Hungarian TPI-deficient brothers. The possible role of cellular components, other than the mutant enzymes, in the distinct behavior of TPI in isolated form versus in hemolysates from the compound heterozygotes and the simple heterozygote family members is discussed. [less ▲]Detailed reference viewed: 15 (0 ULg) Un nouveau projet archéologique de l'Université de Lyon 2.Morard, Thomas ; Wavelet, Davidin Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2001), 113(1), 477-481Detailed reference viewed: 30 (1 ULg) Note sous corr., Bruxelles du 27 juin 2001 (affaire de la Crèche Clovis)Jacobs, Ann in Journal des Procès (2001), (419), 30-31Detailed reference viewed: 27 (5 ULg) Impact des tiques sur la croissance des agneaux DjallonkéHounzangbe, M. S.; Koutinhouin, G. B.; Linton, E. et alin Annales de Médecine Vétérinaire (2001), 145Detailed reference viewed: 35 (2 ULg) A Plea to Bridge the Gap between Antifungals and the Management of OnychomycosisARRESE ESTRADA, Jorge ; Pierard-Franchimont, Claudine ; Pierard, Gérald in American Journal of Clinical Dermatology (2001), 2(5), 281-4Onychomycosis represents a stubborn problem for the clinician facing up to the realities of antifungal treatments. There are obvious discrepancies between data given by in vitro antifungal testings ... [more ▼]Onychomycosis represents a stubborn problem for the clinician facing up to the realities of antifungal treatments. There are obvious discrepancies between data given by in vitro antifungal testings, pharmacodynamics and pharmacokinetics, and those gathered from clinical experience. This critical review is an attempt at bridging the gap between in vitro and in vivo information about oral antifungals that aim to treat onychomycoses. Common sense shows that the in vitro concept of fungicidy cannot be simply extrapolated into clinical practice. Indeed, chlamidoconidia and arthroconidia present in vivo are much more resistant to antifungals than hyphae. Corneofungimetry may be a realistic bioassay in predicting antifungal activity in human infections. Boosting hyphae growth from conidia while taking antifungals is a new and appealing treatment modality that deserves controlled study. [less ▲]Detailed reference viewed: 15 (0 ULg) Continuité de l'information, discontinuités sociales: NTIC, nouvelles formes d'organisation et dialogue socialSchoenaers, Frédéric ; Zune, Marcin Revue de Gestion des Ressources Humaines (2001), 42Detailed reference viewed: 88 (18 ULg) Changes in peroxidase activity, and level of phenolic compounds during light-induced plantlet regeneration from Eucalyptus camaldulensis Dehn. nodes in vitroArezki, Ouoimare; Boxus, Philippe; Kevers, Claire et alin Plant Growth Regulation (2001), 33(3), 215-219Node cultures of Eucalyptus camaldulensis Dehn in Petri dishes in vitro under darkness in the presence of an auxin developed meristematic agglomerates (4 to 6 diameter), i.e. dense shoot clusters in which ... [more ▼]Node cultures of Eucalyptus camaldulensis Dehn in Petri dishes in vitro under darkness in the presence of an auxin developed meristematic agglomerates (4 to 6 diameter), i.e. dense shoot clusters in which outgrowth of numerous successive buds is limited. Similar cultures under a 16 photoperiod produced small green plantlets with reduced leaves often presenting white hypertrophied lenticels and very short roots crowning the stem bases. The use of half-litre glass vials under light allowed direct development of well-developed rooted plantlets, either in the presence of the same auxin or in the presence of a cytokinin. Light favoured an increase in phenolic compounds and a reverse variation of peroxidase activity during the culture cycles. These aspects are discussed in terms of a possible regulation of the endogenous auxin level through a light control of peroxidase activity and the level of phenolic compounds. [less ▲]Detailed reference viewed: 49 (5 ULg) Heroic Fantasy et modernité: la problématique de la quête chez Michael Moorcock et Samuel R. DelanyDelville, Michel in Sources: Revue d'Etudes Anglophones (2001), 11Detailed reference viewed: 131 (8 ULg) Suppression of matching field effects by splay and pinning energy dispersion in YBa2Cu3O7 with columnar defectsNiebieskikwiat, D.; Silhanek, Alejandro ; Civale, L. et alin Physical Review. B : Condensed Matter (2001), 63(14), We report measurements of the irreversible magnetization M-i of a large number of YBa2Cu3O7 single crystals with columnar defects (CD). Some of them exhibit a maximum in M-i when the density of vortices ... [more ▼]We report measurements of the irreversible magnetization M-i of a large number of YBa2Cu3O7 single crystals with columnar defects (CD). Some of them exhibit a maximum in M-i when the density of vortices equals the density of tracks, at temperatures above 40 K. We show that the observation of these matching field effects is constrained to those crystals where the orientational and pinning energy dispersion of the CD system lies below a certain threshold. The amount of such dispersion is determined by the mass and energy of the irradiation ions, and by the crystal thickness. Time relaxation measurements show that the matching effects are associated with a reduction of the creep rate, and occur deep into the collective pinning regime. [less ▲]Detailed reference viewed: 15 (4 ULg) Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation.Minet, E.; Michel, G.; Mottet, Denis et alin Free Radical Biology & Medicine (2001), 31(7), 847-55Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers ... [more ▼]Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers the overexpression of genes coding for glycolytic enzymes and angiogenic factors. To be active HIF-1 must be phosphorylated. HIF-1 is a substrate for various kinase pathways including PI-3K and the MAP kinases ERK and p38. Several transduction pathways have been proposed which act downstream of putative oxygen sensors and lead to the activation of these kinases. In this review, we summarize some of the latest advances describing the possible signaling pathways leading to HIF-1 phosphorylation and subsequent activation. The physiological relevance of these regulations is also discussed. [less ▲]Detailed reference viewed: 21 (1 ULg) Imidazolopyrazinones as potential antioxydantsDevillers, Ingrid; Dive, Georges ; De Tollenaere, Catherine et alin Bioorganic & Medicinal Chemistry Letters (2001), 11(17), 2305-2309Detailed reference viewed: 10 (1 ULg) Est-il raisonnable de prescrire de l'hormone de croissance aux personnes âgées ?Legros, Jean-Jacques ; Geenen, Vincent ; Delmotte, Philippein Revue Médicale de Liège (2001), 56Detailed reference viewed: 7 (0 ULg) Effects of Brassicaceae secondary metabolites on the Glutathione S-transferase activity from Episyrphus balteatus De Geer (Diptera: Syrphidae)Vanhaelen, N.; Haubruge, Eric ; Francis, Frédéric in Pesticide Biochemistry & Physiology (2001), 71(3), 170-177Detailed reference viewed: 33 (1 ULg) Outcome is not improved by the use of alternating chemotherapy in elderly patients with aggressive lymphomaBosly, André; Lepage, Eric; Coiffier, Bertrand et alin Hematology Journal : The Official Journal of the European Haematology Association (2001), 2Detailed reference viewed: 12 (0 ULg) Vesical varices in a patient with portal hypertension.Gaspar, Yves; Detry, Olivier ; de Leval, Jean in New England Journal of Medicine [=NEJM] (2001), 345(20), 1503-4Detailed reference viewed: 57 (10 ULg) Productivity Overshadows Temperature In Determining Soil And Ecosystem Respiration Across European ForestsJanssens, Ia.; Lankreijer, H.; Matteucci, G. et alin Global Change Biology (2001), 7(3), Detailed reference viewed: 38 (1 ULg) Administration of erythopoietin and granulocyte colony-stimulating factor in donor/recipient pairs to collect peripheral blood progenitor cells (PBPC) and red blood cell units for use in the recipient after allogeneic PBPC transplantation.Sautois, Brieuc ; Baudoux, Etienne ; Salmon, Jean et alin Haematologica (2001), 86(11), 1209-18BACKGROUND AND OBJECTIVES: It may be useful to reduce the exposure of transplant recipients to homologous blood. This may be achieved by procuring donor-derived red blood cell (RBC) units, collecting more ... [more ▼]BACKGROUND AND OBJECTIVES: It may be useful to reduce the exposure of transplant recipients to homologous blood. This may be achieved by procuring donor-derived red blood cell (RBC) units, collecting more peripheral blood progenitor cells (PBPC) with a combination of granulocyte colony-stimulating factor (G-CSF) + recombinant human erythropoietin (rHuEpo) and by administering rHuEpo post-transplantation. DESIGN AND METHODS: Eight ABO-compatible donors were treated with rHuEpo and intravenous iron to collect 12 RBC units for use in their recipients. PBPC were collected after mobilization with rHuEpo and G-CSF in the same donors. The recipients received G-CSF and rHuEpo post-transplantation. A control group of 10 donor/recipient pairs received G-CSF alone for PBPC mobilization and after the transplantation. RESULTS: Eighty-six out of 91 planned RBC units were collected in the donors without significant decrease in hematocrit because of a 4-fold increase in RBC production despite functional iron deficiency. After 2 leukaphereses, the cumulative yields of NC and CFU-GM were lower in the study group while those of BFU-E, CFU-Mix and CD34+ cells were similar. However, erythroid recovery was significantly accelerated in the study group. INTERPRETATION AND CONCLUSIONS: Collection of 12 RBC units within 6 weeks is feasible with rHuEpo and intravenous iron; this strategy allows a dramatic reduction in recipient exposure to homologous blood; rHuEpo has no synergistic effect with G-CSF for mobilization of PBPC in normal donors and may even be deleterious; and rHuEpo in the recipient may enhance erythroid engraftment. [less ▲]Detailed reference viewed: 63 (4 ULg) Some properties of generalized age-distribution equations in fluid dynamicsBeckers, Jean-Marie ; Delhez, Eric ; Deleersnijder, Ericin SIAM Journal on Applied Mathematics (2001), 61(5), 1526-1544The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry ... [more ▼]The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry properties arise for the age field. In particular, for a point release, the age field is isotropic, regardless of the direction of the ow and the value of the diffusion coefficient. The analysis is then extended to situations with time-varying currents, where the symmetry can be broken under some circumstances. Finally, we show a method by which a time-dependent problem can be used to assess a stationary concentration distribution function, providing details about the propagation of younger and older material at a given location. [less ▲]Detailed reference viewed: 33 (13 ULg) M. MigeotteBiémont, Emile in Nouvelle Bibliographie Nationale, Académie Royale de Belgique (2001), 6Detailed reference viewed: 27 (4 ULg) Le martin-pêcheur (Alcedo atthis) va-t-il bientôt manquer de sites de nidification ?Libois, Roland in Aves (2001), 38(4), 161-178In south-west Belgium, the breeding of the kingfisher was monitored for more than 10 years. During this period, 158 banks were regularly surveyed. Alterations or potential threats were identified: natural ... [more ▼]In south-west Belgium, the breeding of the kingfisher was monitored for more than 10 years. During this period, 158 banks were regularly surveyed. Alterations or potential threats were identified: natural erosion, cattle trampling, disturbance from kayak-riders or anglers and, last but not least, consolidation works. Only 56 banks (35.4 %) can de considered as "safe". However, since the recent (2001) legal restrictions about the navigation on small rivers, 12 more banks are now safe too. Cattle trampling appears as the main threat (55 sites). However, the enforcement of the law regulating the fences along the rivers could easily solve the problem. Nineteen banks were completely destroyed for different purposes: navigation, road retaining walls or simply anti-erosive measures. Most of these works were undertaken along the river Meuse, the best nidification habitat of the area. (11 photos) [less ▲]Detailed reference viewed: 53 (6 ULg) À la croisée du temps, de l’aspect et du mode: Le conjonctif en néo-égyptienWinand, Jean in Lingua Aegyptia [= LingAeg] (2001), (9), 293-329Detailed reference viewed: 99 (6 ULg) Experimental and Theoretical Energy Levels, Transition probabilities and Radiative Lifetimes in Yb IIIBiémont, Emile ; Garnir, Henri-Pierre ; Li, Z. S. et alin Journal of Physics : B Atomic Molecular & Optical Physics (2001), 34Detailed reference viewed: 23 (2 ULg) The emerging role of class II histone deacetylases.Fischle, Wolfgang; Kiermer, Véronique; Dequiedt, Franck et alin Biochemistry & Cell Biology (2001), 79(3), 337-48Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in all eukaryotes. Several histone acetyltransferases have been identified that ... [more ▼]Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in all eukaryotes. Several histone acetyltransferases have been identified that act as transcriptional coactivators. In contrast, histone deacetylases (HDACs) are part of transcriptional corepressor complexes. Based on their similarity to known yeast factors, the human HDACs are grouped into three classes. Class I HDACs are similar to the yeast transcriptional repressor yRPD3, while class II HDACs are related to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated in cell differentiation and development, and many molecular details are emerging that shed light on class II HDAC function and regulation. We discuss the biological role of these factors in the context of physiological processes. [less ▲]Detailed reference viewed: 167 (5 ULg) Calculated transition probabilities in highly charged Ti-like ionsBiémont, Emile ; Träbert, E.; Zeippen, C. J.in Journal of Physics : B Atomic Molecular & Optical Physics (2001), 34Detailed reference viewed: 12 (3 ULg) Crystal Structure of Human Peroxiredoxin 5, a Novel Type of Mammalian Peroxiredoxin at 1.5 Ǻ ResolutionDeclercq, Jean-Paul; Evrard, Christine ; Clippe, André et alin Journal of Molecular Biology (2001), 311The peroxiredoxins define an emerging family of peroxidases able to reduce hydrogen peroxide and alkyl hydroperoxides with the use of reducing equivalents derived from thiol-containing donor molecules ... [more ▼]The peroxiredoxins define an emerging family of peroxidases able to reduce hydrogen peroxide and alkyl hydroperoxides with the use of reducing equivalents derived from thiol-containing donor molecules such as thioredoxin, glutathione, trypanothione and AhpF. Peroxiredoxins have been identified in prokaryotes as well as in eukaryotes. Peroxiredoxin 5 (PRDX5) is a novel type of mammalian thioredoxin peroxidase widely expressed in tissues and located cellularly to mitochondria, peroxisomes and cytosol. Functionally, PRDX5 has been implicated in antioxidant protective mechanisms as well as in signal transduction in cells. We report here the 1.5 Ǻ resolution crystal structure of human PRDX5 in its reduced form. The crystal structure reveals that PRDX5 presents a thioredoxin-like domain. Interestingly, the crystal structure shows also that PRDX5 does not form a dimer like other mammalian members of the peroxiredoxin family. In the reduced form of PRDX5, Cys47 and Cys151 are distant of 13.8 Ǻ although these two cysteine residues are thought to be involved in peroxide reductase activity by forming an intramolecular disul®de intermediate in the oxidized enzyme. These data suggest that the enzyme would necessitate a conformational change to form a disulfide bond between catalytic Cys47 and Cys151 upon oxidation according to proposed peroxide reduction mechanisms. Moreover, the presence of a benzoate ion, a hydroxyl radical scavenger, was noted close to the active-site pocket. The possible role of benzoate in the antioxidant activity of PRDX5 is discussed. [less ▲]Detailed reference viewed: 33 (0 ULg) Coordinated regulation of procollagens I and III and their post-translational enzymes by dissipation of mechanical tension in human dermal fibroblasts.Lambert, Charles ; Colige, Alain ; Lapiere, C. M. et alin European Journal of Cell Biology (2001), 80(7), 479-85Mechanical tension governs fibroblast proliferation and survival and the homeostasis of the extracellular matrix to adapt its resistance to the mechanical requirements of the organs. To consolidate this ... [more ▼]Mechanical tension governs fibroblast proliferation and survival and the homeostasis of the extracellular matrix to adapt its resistance to the mechanical requirements of the organs. To consolidate this view, we analysed the effect of tension release on the expression of molecules involved in the architecture and stabilisation of the collagen fibres, namely the procollagens type I and III, the amino- and carboxy-procollagen peptidases (N-pCP and C-pCP) and lysyl oxidase. Cells were cultured in conditions of high mechanical stress in monolayer on a collagen coat and under reduced tension by disruption of the cytoskeleton upon treatment with cytochalasin D in monolayer on a collagen coat or by integrin-mediated stress relaxation in a freely retracting collagen gel. The mRNAs were measured by quantitative RT-PCR monitored by simultaneous reverse-transcription and amplification of an original internal standard. Tension relaxation resulted in a decreased expression of the procollagens type I and III, of the two expressed forms of C-pCP, of the two forms of N-pCP and of lysyl oxidase. Type III collagen, known to control diameter of the fibres, was less down-regulated than type I collagen. Interestingly, the expression of the two alternatively spliced forms of the N-pCP was dissimilarly regulated. These data suggest that mechanical tension may modulate the stiffness of the extracellular matrix by controlling not only the level of expression of its fibrillar constituents but also that of the enzymes participating in their extracellular processing and mechanical stabilisation. [less ▲]Detailed reference viewed: 20 (8 ULg)