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See detailECL benchmark: Application of the proper orthogonal decomposition
Lenaerts, Vincent; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in Mechanical Systems & Signal Processing (2003), 17(1), 237-242

The aim of this paper is to apply the proper orthogonal decomposition method to a non-linear system consisting of an experimental cantilever beam with a geometrical non-linearity. (C) 2003 Elsevier ... [more ▼]

The aim of this paper is to apply the proper orthogonal decomposition method to a non-linear system consisting of an experimental cantilever beam with a geometrical non-linearity. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailCoût d'oeil
Gauthier, Jean-Marie ULg

in Cahiers de Psychologie Clinique (2003)

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See detailRandom mutagenesis of PDZOmi domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis
Junqueira, Daniela; Cilenti, Lucia; Musumeci, Lucia ULg et al

in Oncogene (2003), 22

Omi is a mammalian serine protease that is localised in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting ... [more ▼]

Omi is a mammalian serine protease that is localised in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the Xchromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies on its proteolytic activity. Omi is synthesized as a precursor polypeptide and is processed to an active serene protease with a unique PDZ domain. PDZ domains recognise the extreme carboxyl terminus of target proteins. Internal peptides that are able to fold into a b-finger are also reported to bind some PDZ domains. Using a modified yeast two-hybrid system, PDZOmi mutants were isolated by their ability to bind the carboxyl terminus of human Myc oncoprotein in yeast as well as in mammalian cells. One such PDZm domain (PDZ-M1), when transfected into mammalian cells, was able to bind to endogenous Myc protein and induce cell death. PDZ-M1-induced apoptosis was entirely dependent on the presence of Myc protein and was not observed when c-myc null fibroblasts were used. Our studies indicate that the PDZ domain of Omi can provide a prototype that could easily be exploited to target specifically and inactivate oncogenes by binding to their unique carboxyl terminus. [less ▲]

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See detailLaparoscopic liver resection of benign liver tumors - Results of a multicenter European experience
Descottes, B.; Glineur, D.; Lachachi, François et al

in Surgical Endoscopy and Other Interventional Techniques (2003), 17(1), 23-30

Objective: The objective of this study was to assess the feasibility, safety, and outcome of laparoscopic liver resection for benign liver tumors in a multicenter setting. Background: Despite restrictive ... [more ▼]

Objective: The objective of this study was to assess the feasibility, safety, and outcome of laparoscopic liver resection for benign liver tumors in a multicenter setting. Background: Despite restrictive, tailored indications for resection in benign liver tumors, an increasing number of articles have been published concerning laparoscopic liver resection of these tumors. Methods: A retrospective study was performed in 18 surgical centres in Europe regarding their experience with laparoscopic resection of benign liver tumors. Detailed standardized questionnaires were used that focused on patient's characteristics, clinical data, type and characteristics of the tumor, technical details of the operation, and early and late clinical outcome. Results: From March 1992 to September 2000, 87 patients suffering from benign liver tumor were included in this study: 48 patients with focal nodular hyperplasia (55%), 17 patients with liver cell adenoma (21%), 13 patients with hemangioma (15%), 3 patients with hamartoma (3%), 3 patients with hydatid liver cysts (3%), 2 patients with adult polycystic liver disease (APLD) (2%), and 1 patient with liver cystadenoma (1%). The mean size of the tumor was 6 cm, and 95% of the tumors were located in the left liver lobe or in the anterior segments of the right liver. Liver procedures included 38 wedge resections, 25 segmentectomies, 21 bisegmentectomies (including 20 left lateral segmentectomies), and 3 major hepatectomies. There were 9 conversions to an open approach (10%) due to bleeding in 45% of the patients. Five patients (6%) received autologous blood transfusion. There was no postoperative mortality, and the postoperative complication rate was low (5%). The mean postoperative hospital stay was 5 days (range, 2-13 days). At a mean follow-up of 13 months (median, 10 months; range, 2-58 months), all patients are alive without disease recurrence, except for the 2 patients with APLD. Conclusions: Laparoscopic resection of benign liver tumors is feasible and safe for selected patients with small tumors located in the left lateral segments or in the anterior segments of the right liver. Despite the use of a laparoscopic approach, selective indications for resection of benign liver tumors should remain unchanged. When performed by expert liver and laparoscopic surgeons in selected patients and tumors, laparoscopic resection of benign liver tumor is a promising technique. [less ▲]

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See detailCompte-rendu de l'ouvrage Interviste a d'Annunzio (1895-1938)
Curreri, Luciano ULg

in ARIEL. Quadrimestrale di drammaturgia dell'Istituto di Studi pirandelliani e sul Teatro Italiano Contempornaeo (2003), 1

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function
Dogné, Jean-Michel ULg; de Leval, X.; Kolh, Philippe ULg et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003), 68(1), 49-54

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and ... [more ▼]

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and thromboxane synthase of human platelets. The drug affinity for TP receptors of human washed platelets has been determined. In this test BM-567 showed a high affinity (IC50: 1.1+/-0.1 nM) for the TP receptors in comparison with BM-531 (IC50: 7.8+/-0.7 nM) and sulotroban (IC50: 931+/-85 nM), two TXA(2) antagonists. We also demonstrated that BM-567 prevented platelet aggregation induced by arachidonic acid (AA) (600 muM) (ED100: 0.20+/-0.10muM), U-46619, a stable TXA(2) agonist (1 muM) (ED50: 0.30+/-0.04 muM) and collagen (1 mug ml(-1)) (% of inhibition: 44.3+/-4.3% at 10 muM) and inhibited the second wave of ADP (2 muM). Moreover, when BM-567 was incubated in whole blood from healthy donors, the closure time measured by the Platelet Function analyzer (PFA-100) was significantly prolonged (closure time: 215+/-21 s) by using collagen/epinephrine cartridges. Finally, at the concentration of 1 muM, BM-567 completely reduced the TXB2 production from human platelets stimulated with AA (600 muM). These results indicate that BM-567 is a novel combined TXA(2) receptor antagonist and thromboxane synthase inhibitor characterized by a powerful antiplatelet potency. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailWorking group 3- Identification of non-linear systems
Golinval, Jean-Claude ULg; Kerschen, Gaëtan ULg; Lenaerts, V. et al

in Mechanical Systems & Signal Processing (2003), 17(1), 177-178

Researchers in structural dynamics have long recognised the importance of diagnosing and modelling non-linearity. The last 20 years have witnessed a shift in emphasis from single degree-of-freedom (sdof ... [more ▼]

Researchers in structural dynamics have long recognised the importance of diagnosing and modelling non-linearity. The last 20 years have witnessed a shift in emphasis from single degree-of-freedom (sdof) to multi-degree-of-freedom (mdof) non-linear structural dynamics. The main feature of the program of COST F3 Working Group 3 was to identify the behaviour of a structure which exhibits a localised non-linear component. Inside this working group, two benchmarks were defined and studied intensively, thereby allowing to evaluate different identification methods and compare their efficiency and specificity. For this purpose, a large amount of data (time and frequency measurements) was collected and proposed to COST F3 participants. The two benchmarks that are described in the following are: * The VTT benchmark proposed by M. Juntunen from the VTT Technical Research of Finland; * The ECL benchmark proposed by F. Thouverez from the Ecole Centrale de Lyon (France). The VTT benchmark is essentially one-dimensional but with a type of non-linearity that is not known a priori. This is different from the ECL benchmark designed to implement a cubic stiffness hardening but which address mdof systems. The ECL benchmark was challenging in the sense that the considered structure is continuous and that several modes participate in the response. *Supported by a grant from the Belgian National Fund for Scientific Research. # 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailL'air du temps : Un souffle d'oxygène pour des collections d'horlogerie
Drouguet, Noémie ULg

in Art&Fact (2003), 22

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See detailExcitability of visual V1-V2 and motor cortices to single transcranial magnetic stimuli in migraine: a reappraisal using a figure-of-eight coil.
Bohotin, V.; Fumal, Arnaud ULg; Vandenheede, M. et al

in Cephalalgia : An International Journal of Headache (2003), 23(4), 264-70

We used transcranial magnetic stimulation (TMS) with a figure-of-eight coil to excite motor and visual V1-V2 cortices in patients suffering from migraine without (MO) (n = 24) or with aura (MA) (n = 13 ... [more ▼]

We used transcranial magnetic stimulation (TMS) with a figure-of-eight coil to excite motor and visual V1-V2 cortices in patients suffering from migraine without (MO) (n = 24) or with aura (MA) (n = 13) and in healthy volunteers (HV) (n = 33). Patients who had a migraine attack within 3 days before or after the recordings were excluded. All females were recorded at mid-cycle. Single TMS pulses over the occipital cortex elicited phosphenes in 64% of HV, 63% of MO and 69% of MA patients. Compared with HV, the phosphene threshold was significantly increased in MO (P = 0.001) and in MA (P = 0.007), but there was no difference between the two groups of migraineurs. The motor threshold tended to be higher in both migraine groups than in HV, but the differences were not significant. In conclusion, this study shows that two-thirds (64.86%) of patients affected by either migraine type present an increased phosphene threshold in the interictal period, which suggests that their visual cortex is hypoexcitable. [less ▲]

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See detailDownregulation of putative tumor suppressor gene TSC-22 in human brain tumors.
Shostak, Kateryna ULg; Dmitrenko, Vladimir V.; Garifulin, Oleg M. et al

in Journal of Surgical Oncology (2003), 82(1), 57-64

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and ... [more ▼]

BACKGROUND AND OBJECTIVES: Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS: Screening of arrayed human fetal brain and human postnatal brain cDNA libraries was performed by differential hybridization with glioblastoma multiforme and human normal brain cDNAs. RESULTS: Repeated differential hybridization of more than 100 cDNA clones selected by primary screening and analysis of RNA from adult normal brain and glial tumors showed 16 nucleotide sequences differentially expressed between normal brain and brain tumors. Among others, decreased content in astrocytic tumors was determined for TSC-22 mRNA corresponding to cDNA in the ICRFp507J1041 clone from human fetal brain cDNA library. Northern blot hybridization of RNA from different human brain tumors showed very low amounts of TSC-22 mRNA in most investigated samples of GBM, anaplastic astrocytoma, and some other tumors. Complete lack of expression of TSC-22 occurred in one sample of anaplastic astrocytoma, as well as in meningioma, brain sarcoma, sarcomatous meningioma, and oligodendroglioma. The differential expression of TSC-22 gene was confirmed by semiquantitative RT-PCR in 15 samples of astrocytomas WHO grade II-IV and three samples of normal brain. CONCLUSIONS: Significantly decreased levels of TSC-22 mRNA in human brain and salivary gland tumors and antiproliferative role of TSC-22 strongly suggest a tumor suppressor role for TSC-22. J. [less ▲]

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See detailNitric oxide and cardiac function: ten years after, and continuing.
MASSION, Paul ULg; Feron, O.; Dessy, C. et al

in Circulation Research (2003), 93(5), 388-98

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The former include regulation ... [more ▼]

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The former include regulation of coronary vessel tone, thrombogenicity, and proliferative and inflammatory properties as well as cellular cross-talk supporting angiogenesis. The latter comprise the direct effects of NO on several aspects of cardiomyocyte contractility, from the fine regulation of excitation-contraction coupling to modulation of (presynaptic and postsynaptic) autonomic signaling and mitochondrial respiration. This multifaceted involvement of NO in cardiac physiology is supported by a tight molecular regulation of the three NO synthases, from cellular spatial confinement to posttranslational allosteric modulation by specific interacting proteins, acting in concert to restrict the influence of NO to a particular intracellular target in a stimulus-specific manner. Loss of this specificity, such as produced on excessive NO delivery from inflammatory cells (or cytokine-stimulated cardiomyocytes themselves), may result in profound cellular disturbances leading to heart failure. Future therapeutic manipulations of cardiac NO synthesis will necessarily draw on additional characterization of the cellular and molecular determinants for the net effect of this versatile radical on the cardiomyocyte biology. [less ▲]

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See detailHarm avoidance is related to mismatch negativity (MMN) amplitude in healthy subjects
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Scantamburlo, Gabrielle ULg et al

in Personality & Individual Differences (2003), 34(6), 1039-1048

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on ... [more ▼]

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on the possible relationships between personality and automatic attention or early sensory processing. In the present study the relationships between the mismatch negativity (MMN) and personality described by the Cloninger model of personality were investigated. Subjects were 32 healthy volunteers. The MMN was recorded with frequent stimuli tones of 1470 Hz, 70 dB and 40 ms duration, and target (20%) tones of 1470 Hz, 70 dB, 80 ms duration. The subjects completed a French version of the 226-item self-questionnaire TCI within the day following psychophysiological recording. The results showed that the HA dimension was negatively correlated with the MMN amplitude. The association was more present among women than men. No significant relationship existed between the other dimensions of personality and either the MMN amplitude or latency. These findings suggest that the MMN is related to the behavioral inhibition system (BIS), a fact which is consistent with clinical studies conducted on schizophrenia and anxiety disorders. In conclusion, this study suggests that personality dimensions induce different automatic attitudes towards the processing of information. (C) 2002 Published by Elsevier Science Ltd. [less ▲]

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See detailEffect of histamine on lung contractile elements in growing cattle
Jolly, Sandra ULg; Robinson, Edward; Desmecht, Daniel ULg

in American Journal of Veterinary Research (2003), 64

OBJECTIVE: To determine the effect of histamine on the contractile elements of the respiratory tract in neonatal calves and young adult cattle. SAMPLE POPULATION: Samples of trachealis muscle, bronchi ... [more ▼]

OBJECTIVE: To determine the effect of histamine on the contractile elements of the respiratory tract in neonatal calves and young adult cattle. SAMPLE POPULATION: Samples of trachealis muscle, bronchi, and intrapulmonary arteries and veins dissected from the respiratory tracts of healthy bovids (2 to 8 days and 16 to 20 months old). PROCEDURE: Histamine cumulative concentration-effect curves (10(-6) to 10(-3) M) were constructed in duplicate smooth muscle samples mounted in organ baths. Contractile responses to histamine were compared with reference contractions elicited by methacholine (10(-5) M) for airways or KCl (127 mM) for vessels. RESULTS: In young adult cattle, trachealis muscle had a substantial contractile response to histamine (84% of methacholine-induced contraction), whereas bronchi reacted slightly (15 and 20% for large and small bronchi, respectively). Although contractile responses to KCl were comparable in arteries and veins, histamine-induced contractions were greater for intrapulmonary veins than for arteries (202 vs 48% of KCl-induced contraction). In neonatal calves, histamine-induced contraction of veins also exceeded that of arteries (230 vs 54% of KCl-induced contraction); however, unlike in young adult cattle, histamine produced notable contraction of large and small bronchi (48 and 60% of methacholine-induced contraction, respectively). CONCLUSIONS AND CLINICAL RELEVANCE: Compared with intrapulmonary arteries, intrapulmonary veins have greater contractile responses to histamine in neonatal and young adult cattle. Data suggest loss of histamine responsiveness in bronchial smooth muscle as neonatal calves grow to young adults. Venodilation may be useful in treatment of lung edema in cattle. [less ▲]

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See detailSolution structural study of BlaI: implications for the repression of genes involved in beta-lactam antibiotic resistance.
Melckebeke, Helene Van; Vreuls, Christelle ULg; Gans, Pierre et al

in Journal of Molecular Biology (2003), 333(4), 711-20

beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam antibiotics, which are otherwise highly clinically effective. Two repressors (BlaI and MecI) regulate ... [more ▼]

beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam antibiotics, which are otherwise highly clinically effective. Two repressors (BlaI and MecI) regulate expression of these inducible proteins. Here, we present the first solution structure of the 82 amino acid residue DNA-binding domain of Bacillus licheniformis BlaI which is very similar in primary sequence to the medically significant Staphyloccocal BlaI and MecI proteins. This structure is composed of a compact core of three alpha-helices and a three-stranded beta-sheet typical of the winged helix protein (WHP) family. The protein/DNA complex was studied by NMR chemical shift comparison between the free and complexed forms of BlaI. Residues involved in DNA interaction were identified and a WHP canonical model of interaction with the operators is proposed. In this model, specific contacts occur between the base-pairs of the TACA motif and conserved amino acid residues of the repressor helix H3. These results help toward understanding the repression and induction mechanism of the genes coding for beta-lactamase and PBP2'. [less ▲]

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See detailUtilisation des scories métallurgiques en dynamique fluviale : détermination de la compétence effective des rivières et estimation des vitesses de progression de la charge de fond.
Houbrechts, Geoffrey ULg; Petit, François ULg

in Géomorphologie : Relief, Processus, Environnement (2003), (1), 3-12

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées ... [more ▼]

Les compétences effectives de trois rivières du nord de l’Ardenne (Belgique) ont pu être estimées grâce à la présence de nombreuses macroscories dans leur charge de fond. En effet, ces scories, rejetées par les anciens fondeurs dans les rivières, ont été soumises, pendant plusieurs siècles, à de nombreuses crues mobilisatrices. Par conséquent, elles peuvent être considérées comme un marqueur représentatif de la compétence effective des rivières sur une très longue période et sur une grande distance. Ainsi, en comparant la taille des scories en amont et en aval d’un secteur de pertes karstiques (plusieurs kilomètres), nous avons montré que ces pertes n’entraînent pas de baisse sensible de la compétence de la rivière. Une relation entre la taille des scories prélevées et les puissances spécifiques développées dans les secteurs de prélèvement a également été établie. Cette relation montre que le maximum de puissance spécifique des rivières ardennaises se produit dans les rivières dont le bassin versant est voisin de 150 km². Finalement, des scories retrouvées dans l’Ourthe, environ 10 km en aval du site de production le plus proche, ont été utilisées pour évaluer la vitesse de progression de la « vague sédimentaire ». En effet, ces scories sont soumises aux mêmes conditions hydrologiques et de piégeage que les éléments naturels de la charge de fond. Après avoir daté le début du fonctionnement du site de production le plus proche (1450), nous avons calculé la vitesse de progression des scories qui est comprise entre 1,8 et 2,3 km/siècle. [less ▲]

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See detailMaking sense of the industrial revolution, English economy and society 1700-1850.
Geerkens, Eric ULg

in Revue Belge de Philologie et d'Histoire (2003), 81(2), 519-521

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See detailDe ereburgers. Een sociale geschiedenis van de Limburgse mijnwerkers
Geerkens, Eric ULg

in Cahiers d'Histoire du Temps Présent = Bijdragen tot de Eigentijdse Geschiedenis (2003), 11

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See detailCalculation of optical absorption spectra of hydrogenated Si clusters: Bethe-Salpeter equation versus time-dependent local-density approximation
Benedict, L. X.; Puzder, A.; Williamson, A. J. et al

in Physical Review. B : Condensed Matter (2003), 68(8), 85310-1-85310-85310-885310-85310-8

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE ... [more ▼]

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE) with a model dielectric function, and the time-dependent density-functional theory within the adiabatic local-density approximation (TDLDA). Single-particle states are obtained from local-density approximation (LDA) calculations and, for the BSE calculation, a quasiparticle gap correction is provided by quantum Monte Carlo calculations. We find that the exchange-correlation kernel of the TDLDA has almost no effect on the calculated spectra, while the corresponding attractive part of the electron-hole interaction of the BSE produces enhanced absorptive features at low energies. For the smallest cluster SiH 4, the two methods produce markedly different results, with the TDLDA spectra appearing closer to the experimental result. The gross features of the TDLDA and BSE spectra for larger clusters are however similar, due to the strong repulsive Coulomb kernel present in both treatments [less ▲]

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See detailAnatomische, histologische en immunologische aspecten van de tonsille bij het schaap in het kader van de BSE problematiek
Cocquyt, G.; Gabriel, Annick ULg; Van den Broeck, W.

in Vlaams Diergeneeskundig Tijdschrift (2003), 72

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See detailEfficacité du piégeage, par les méthodes classiques, des coléoptères saproxyliques en Région wallonne (Belgique)
Lhoir, Jonathan; Fagot, Jean ULg; Thieren, Yves et al

in Notes Fauniques de Gembloux (2003), 50

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont ... [more ▼]

By definition, saproxylic fauna is discrete and hidden. The authors have tested several technics of trapping, in the beech forest of Rurbusch (Elsenborn village) and in the oak forest of Mohimont (Daverdisse village). Both forests are caracterized by a large amount of dead wood standing and laying down. The trapping's results are presented, with regards on the different technics used, on the differences between sites, on the beetles families and their saproxylic behavior. [less ▲]

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See detailIn vitro paradigms for the study of GnRH neuron function and estrogen effects.
Matagne, Valerie; LEBRETHON, Marie-Christine ULg; Gerard, Arlette et al

in Annals of the New York Academy of Sciences (2003), 1007

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency ... [more ▼]

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency of GnRH secretion, the excitatory effect of glutamate, and the inhibitory or excitatory effect of GABA. Among the different paradigms, the fetal olfactory placode cultures exhibit the unique property of migration in vitro and may retain the capacity to undergo maturational changes in vitro. The short-term incubation of hypothalamic explants obtained at different ages enables one to study developmental changes as well. Estrogens may have important roles in the regulation of GnRH function and can act indirectly via the neighboring neuronal/glial apparatus and directly on GnRH neurons at the cell body and terminal levels. A direct effect is supported by the recent localization of ERalpha and ERbeta transcripts in GnRH neurons using most paradigms. Discrepant effects of estrogens on GnRH neurons were observed since GnRH biosynthesis is inhibited while GnRH secretion can be either stimulated, unaffected, or reduced. It is likely that the regulatory role of sex steroids including estradiol is very complex since it could involve direct and indirect effects on GnRH neurons through genomic and/or non-genomic mechanisms. [less ▲]

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See detailTransfigurative Art: Wilson Harris's The Mask of the Beggar
Maes-Jelinek, Hena ULg

in Moving Worlds : A Journal of Transcultural Writings (2003), 3(2), 12-26

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See detailCalorimetry of cationic liposome-DNA complex and intracellular visualization of the complexes.
Elouahabi, Abdelatif; Thiry, Marc ULg; Pector, Veronique et al

in Methods in Enzymology (2003), 373

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See detailLes groupes d'entraide ou l'émergence de dynamiques citoyennes
Biquet, Véronique ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2003), 39

L'article montre comment les groupes d'entraide peuvent constituer des lieux d'émergence de dynamiques citoyennes, en permettant qu'un pont soit crée entre l'espace privé des relations interpersonnelles ... [more ▼]

L'article montre comment les groupes d'entraide peuvent constituer des lieux d'émergence de dynamiques citoyennes, en permettant qu'un pont soit crée entre l'espace privé des relations interpersonnelles et l'espace public des questions relatives à la cité. [less ▲]

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See detailIntérêt du monitoring continu du glucose interstitiel chez le patient diabétique de type 1
RADERMECKER, Régis ULg; Sélam, Jean-Louis; SCHEEN, André ULg

in Revue Médicale Suisse (2003), 61

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See detailFungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.
Francis, Frédéric ULg; Marty-Detraves, Claire; Poincloux, Renaud et al

in European Journal of Cell Biology (2003), 82(10), 515-22

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect ... [more ▼]

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect-resistant transgenic plants, we investigated the effects of XCL at the cellular level. Immunofluorescence microscopy studies revealed that XCL is rapidly internalized into small endocytic vesicles that further coalesce in the perinuclear region. We show that XCL is endocytosed by the clathrin-dependent pathway, and is delivered to late endosome/lysosome compartments. The internalization of XCL seems to be general since it occurs in different cell types such as insect (SF9) or mammalian (NIH-3T3 and Hela) cell lines. In the presence of XCL, the uptake of GFP and BSA is greatly enhanced, demonstrating that XCL facilitates endocytosis. Thus, XCL could serve as a delivery agent to facilitate the endocytosis of proteins that do not enter the cell alone. [less ▲]

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See detailXylanase Production By Penicillium Canescens 10-10c In Solid-State Fermentation
Bakri, Y.; Jacques, Philippe ULg; Thonart, Philippe ULg

in Applied Biochemistry and Biotechnology (2003), 105

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See detailTowards an Understanding of Hafting: the macro- and microscopic evidence
Rots, Veerle ULg

in Antiquity (2003), 77(298), 805-815

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See detailDistinction Between Cultivated And Wild Chicory Gene Pools Using Aflp Markers
Van Cutsem, P.; Du Jardin, Patrick ULg; Boutte, C. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (2003), 107(4),

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See detailEffet des bordures de champs sur les populations de Chrysopes [Neuroptera: Chrysopidae] en cultures maraîchères
Mignon, Jacques ULg; Colignon, Pierre; Haubruge, Eric ULg et al

in Phytoprotection (2003), 84(2), 121-128

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and ... [more ▼]

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and Coccinellidae is well known but very few studies have been realised to assess its effect on the abundance and diversity of Chrysopidae. In 2000 and 2001, the impact of adjacent habitats on lacewing populations was investigated in both carrot and broad bean open fields. Three types of field borders were selected: (1) set-asides mainly composed by Lolium perenne and Trifolium spp., (2) crops (wheat, beet or other vegetables) and (3) woody areas (mixture of Acer sp., Populus sp. and Salix sp.). Insects were caught using yellow pan traps. Chrysopidae populations were shown to be significantly lower in carrot and broad bean fields bordered with woodland. Lacewing and other Neuroptera species richness were always low and were discussed in relation with their role of pest predators associated with other aphidophagous insects. [less ▲]

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See detailField-dependent vortex pinning strength in a periodic array of antidots
Silhanek, Alejandro ULg; Raedts, S.; Lange et al

in Physical Review. B : Condensed Matter (2003), 67(6),

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime ... [more ▼]

We explore the dynamic response of vortex lines in a Pb thin film with a periodic array of antidots by means of ac-susceptibility measurements. For low drive field amplitudes, within the Campbell regime, vortex motion is of intravalley type and the penetration depth is related to the curvature of the pinning potential well alpha. For dc fields below the first matching field H-1, alpha reaches its highest value associated with a Mott insulator like phase where vortex lines are strongly localized at the pinning sites. For H-1<H-dc<H-2, the response is mainly due to the interstitial vortices and α drops to smaller values as expected for this metallic like regime. Strikingly, for H-2<H-dc<H-3, we observe that α reduces further down. However, for H-3<H-dc<H-4, a reentrance in the pinning strength is observed, due to a specific configuration of the flux-line lattice which strongly restricts the mobility of vortices. We present a possible explanation for the measured α(H-dc) dependence based on the different flux-line lattice configurations. [less ▲]

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See detailNitric oxide synthase inhibition lowers activity of neurons with meningeal input in the rat spinal trigeminal nucleus
De Col, R.; Koulchitsky, Stanislav ULg; Messlinger, K. B.

in Neuroreport (2003), 14(2), 229-32

Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn and the spinal trigeminal nucleus, where nociceptive information from extra- and intracranial tissues ... [more ▼]

Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn and the spinal trigeminal nucleus, where nociceptive information from extra- and intracranial tissues is processed. Extracellular impulse activity was recorded from neurons in the rat spinal trigeminal nucleus with afferent input from the cranial dura mater. In contrast to the inactive isomer D-NAME, infusion of the nitric oxide synthase inhibitor L-NAME (20 mg/kg) significantly reduced neuronal activity and increased systemic blood pressure. It is concluded that nitric oxide production contributes to the ongoing activity of sensitized neurons in the spinal trigeminal nucleus. The results suggest that nitric oxide may be involved in the generation and maintenance of primary headaches such as migraine. [less ▲]

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See detailNew illumination technique for IR-video guided patch-clamp recording from neurons in slice cultures on biomembrane
Alix, Philippe ULg; Winterer, J; Muller, W

in Journal of Neuroscience Methods (2003), 128

Slice cultures on biomembrane are the method of choice for studying Ca2 -dependent plastic changes occurring over several days to weeks. Using IR-differential interference contrast, good visualization of ... [more ▼]

Slice cultures on biomembrane are the method of choice for studying Ca2 -dependent plastic changes occurring over several days to weeks. Using IR-differential interference contrast, good visualization of neurons in biomembrane slice cultures has been achieved despite a negative optical effect of the biomembrane, but epifluorescence imaging requires removal of a Wollaston prism and the analyzer. Here, we describe a novel illumination method to overcome this problem. Using optic fiber illumination at a shallow angle from the top of the slice culture, with or without additional illumination from the bottom, we obtained good cellular resolution of neurons in biomembrane slice cultures as well as in acute slices with an infrared-video camera. With this technique, we demonstrate visually guided whole-cell patch-clamp recording of Na - and K -currents as well as combination of whole-cell recording with fluorescence imaging of hippocampal and entorhinal cortex neurons in biomembrane slice cultures. Our inexpensive method should prove very useful for studying in vitro effects of long-term manipulations on membrane currents and intracellular Ca2 -signaling. # 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailElectroplating moulds using dry film thick negative photoresist
Kukharenka, Elena; Farooqui, Mateen M.; Grigore, L. et al

in Journal of Micromechanics and Microengineering (2003), 13(4), 67-74

This paper reports on progress on the feasibility of fabricating moulds for electroplating using Ordyl P-50100 (negative) acrylate polymer based dry film photoresist, commercially available from Elga ... [more ▼]

This paper reports on progress on the feasibility of fabricating moulds for electroplating using Ordyl P-50100 (negative) acrylate polymer based dry film photoresist, commercially available from Elga Europe (http://www.elgaeurope.it). We used this photoresist as an alternative to SU8 negative epoxy based photoresist, which is very difficult to process and remove after electroplating (Lorenz et al 1998 Microelectron. Eng. 41/42 371–4, Eyre et al 1998 Proc. MEMS’98 (Heidelberg) (Piscataway, NJ: IEEE) pp 218–22). Ordyl P-50100 is easy to work with and can be easily removed after processing. A single layer of Ordyl P-50100 was deposited by lamination up to 20 µm thickness. Thicker layers (200 µm and more) can be achieved with multilayer lamination using a manual laminator. For our applications we found that Ordyl P-50100 dry film photoresist is a very good alternative to SU8 for the realization of 100 µm high moulds. The results presented will open up new possibilities for low-cost LIGA-type processes for MEMS applications. [less ▲]

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See detailDe overmoed van de toevallige standaard
Meesters, Gert ULg

in Over Taal (2003), 42(5), 106-107

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See detailLes compétences des jeunes de 15 ans en Communauté française en lecture, en mathématiques et en sciences : résultats de l'enquête PISA 2000
Lafontaine, Dominique ULg; Baye, Ariane ULg; Burton, Réginald et al

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 13-14

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See detailUtilisation du tableur Excel pour le remboursement d'un emprunt par une annuité
Henry, Valérie ULg; Coolen, Annette ULg

in Mathématique et Pédagogie (2003), 143

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See detailRealization of electroplating molds with thick positive SPR 220-7 photoresist
Kukharenka, Elena; Kraft, Michael ULg

in Journal of Materials Science: Materials in Electronics (2003), 14(5-7), 319--322

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See detailFraming the future of antifungals in atopic dermatitis.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 398-400

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease. Some fungal colonization or infection of the skin may exacerbate AD severity, particularly the so-called head and neck variant. In ... [more ▼]

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease. Some fungal colonization or infection of the skin may exacerbate AD severity, particularly the so-called head and neck variant. In addition, excessive intestinal colonization by Candida albicans may represent an additional triggering factor. Hence, there is a rationale to use antifungals in selected AD patients. Early trials with topical ketoconazole in head and neck AD showed a decrease in Malassezia colonization, but no significant improvement was observed in the clinical severity. In contrast, clinical improvement and decreased serum IgE were obtained in patients with positive Malassezia radioallergosorbent tests (RASTs) who were treated by oral ketoconazole. Some preliminary data suggested that oral itraconazole treatment in AD patients reduced the need for topical corticosteroids, provided clinical improvement particularly in head and neck AD, reduced the cutaneous and intestinal fungal colonization that may trigger AD, reduced the percentage of positive Malassezia cultures and demonstrated a decrease in C. albicans and Malassezia RAST values. Furthermore, beside its antifungal action, itraconazole in part relieves pruritus and inflammation. In conclusion, oral itraconazole treatment can alleviate AD severity in selected patients. Fluconazole is also effective. Further research is warranted to identify whether the load in skin surface fungal agents, the fungal RAST values and specific prick testing should be assessed in order to optimize the antifungal management in AD patients. [less ▲]

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See detailObscure Sorrow Hill, The Caribbean Source of Wilson Harris's Fiction
Maes-Jelinek, Hena ULg

in Caribbean Writer (The) (2003), 17

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See detailCalculation of the scattering coefficient of a sine-shaped surface by using the BEM method
De Geetere, L.; Embrechts, Jean-Jacques ULg; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 75-83

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See detailLa varicelle et le zona ou les mystères de la latence d'un virus et de sa réactivation
Rentier, Bernard ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2003), 158(3-4), 169-73174-5

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features: chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological ... [more ▼]

Varicella-zoster virus is a Herpesvirus responsible for three distinct clinical features: chicken pox (varicella), shingles (herpes zoster) and post-zosterian pain (post-herpetic neuralgia). Neurological features of these diseases such as complications of chicken pox, viral latency in sensory ganglia and reactivation as shingles with concurrent and possibly subsequent prolonged pain, are the sequels of the invasion of the peripheral nervous system during primary infection. Prevention is achieved by vaccination with a live attenuated virus strain and therapy calls for specific antiviral agents. In many respects, vzv behaves differently from close relatives. In particular, viral latency in the nervous system is basically different from that of other Herpesviridae. The recent discovery of the expression of some viral regulatory proteins during latency, although it had always been considered that vzv latency was silent, and demonstration that these proteins are immunogenic open new avenues concerning the immune control of vzv reactivation. [less ▲]

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See detailCalculation of the scattering coefficient of a sine-shaped surface by solving the Helmholtz integral
Embrechts, Jean-Jacques ULg; De Geetere, L.; Vermeir, G.

in Proceedings of the Institute of Acoustics (2003), 25(5), 67-74

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See detailConfronti piacentino-bergamaschi: alla ricerca delle radici emiliane della cultura figurativa dei Fantoni
Bugini, Mariaelena ULg

in Atti dell'Ateneo di Scienze, Lettere ed Arti di Bergamo (2003), a.a. 2001/2002

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See detailProgramme de cartographie hydrogéologique de la Région wallonne.
Dossin, F.; Bouezmarni, Mohamed ULg; Habils, F. et al

in Eco Karst (2003), (57), 7-10

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See detailCamouflage et dislocation : de l’alexandrin au vers libre chez Breton et Cocteau
Purnelle, Gérald ULg

in Revue des Lettres Modernes. Jean Cocteau (2003), 4

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See detailHierarchically mesoporous/macroporous metal oxides templated from polyethylene oxide surfactant assemblies
Blin, J.-L.; Léonard, Alexandre ULg; Yuan, Z.-Y. et al

in Angewandte Chemie International Edition (2003), 42(25), 2872-2875

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like ... [more ▼]

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like shape (tapered towards the center) and are arranged parallel to each other and perpendicular to the tangent of the particle surface (see micrographs). The mesochannels are interconnected with funnel-like macrochannels. [less ▲]

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See detailMoins-values et plus-values d'urbanisme: La révision de l'article 70 du CWATUP
Pâques, Michel ULg

in Revue du Notariat Belge (2003)

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See detailL'image du mois. Un chancre mou.
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(2), 64-6

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See detailTwo-dimensional harmonic balance finite element modelling of electrical machines taking motion into account
Gyselinck, Johan; Dular, Patrick ULg; Vandevelde, Lieven et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2003), 22(4), 1021-1036

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system ... [more ▼]

An original and easy-to-implement method to take into account movement (motion) in the 2D harmonic balance finite element modelling of electrical machines is presented The global harmonic balance system of algebraic equations is derived by applying the Galerkin approach to both the space and time discretisation. The harmonic basis functions, i.e. a cosine and a sine function for each nonzero frequency and a constant function 1 for the DC component, are used for approximating the periodic time variation as well as for weighing the time domain equations in the fundamental period. In practice, this requires some elementary manipulations of the moving band stiffness matrix. Magnetic saturation and electrical circuit coupling are considered in the analysis as well. As an application example, the noload operation of a permanent-magnet machine is considered. The voltage and induction waveforms obtained with the proposed harmonic balance method are shown to converge well to those obtained with time stepping. [less ▲]

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See detailMarine mammals from Northeast Atlantic: relationship between their trophic status as determined by delta C-13 and delta N-15 measurements and their trace metal concentrations
Das, Krishna ULg; Beans, Cristina; Holsbeek, Ludo et al

in Marine Environmental Research (2003), 56(3),

The relationship between trophic position through delta(13)C and delta(15)N and trace metal concentrations (Zn, Cd, Cu and Hg) was investigated in the tissues of six marine mammal species from the ... [more ▼]

The relationship between trophic position through delta(13)C and delta(15)N and trace metal concentrations (Zn, Cd, Cu and Hg) was investigated in the tissues of six marine mammal species from the Northeast Atlantic: striped dolphin Stenella coeruleoalba, common dolphin, Delphinus delphis. Atlantic white-sided dolphin Lagenorhynchus acutus, harbour porpoise Phocoena phocoena, white beaked-dolphin Lagenorhynchus albirostris, grey seal Halichoerus grypus stranded on French Channel and Irish coasts. White-beaked dolphins, harbour porpoises, white-sided dolphins, common and striped dolphins display the same relative and decreasing trophic position, as measured by delta(15)N values, along both the Irish and French channel coasts, reflecting conservative trophic habits between these two places. Hepatic and renal Cd concentrations were significantly correlated to muscle delta(13)C and delta(15)N values while Hg, Zn and Cu did not. These results suggest that Cd accumulation is partly linked to the diet while other factors Such as age or body condition might explain Hg, Zn or Cu variability in marine mammals. Combined stable isotope and trace metal analyses appear to be useful tools for the study of marine mammal ecology. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailUn syndrome de Netherton atypique
EL HAYDERI, Lara ULg; DEZFOULIAN, Bita ULg; NIKKELS, Arjen ULg

in Skin (2003), 16(5), 38

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See detailNecrotizing varicella zoster virus folliculitis.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in European Journal of Dermatology (2003), 13(6), 587-9

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented ... [more ▼]

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented with a single large infiltrated plaque on the abdomen. Although histology showed a necrotizing folliculitis surrounded by a dense perifollicular inflammatory infiltrate, the clinical presentation was not suggestive of folliculitis. Subtle cyto-histological clues for viral infection were suggested. Immunohistochemistry revealed the presence of VZV in the remnants of the follicular structures. This report underlines one of the protean clinical presentations of VZV skin infections and highlights the discreteness of typical VZV-related cyto-histological alterations. Complementary VZV identification methods such as immunohistochemistry, are helpful in order to increase the diagnostic accuracy of unusual VZV lesions. [less ▲]

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See detailUse of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury
Wirth, D.; Christians, E.; Li, Xiang ULg et al

in Toxicology and Applied Pharmacology (2003), 192(1), 12-20

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection ... [more ▼]

Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological changes occurring after Cd intranasal instillation (1 to 100 microg/mouse) was examined. HSF1-deficient mice were used to evaluate the role of this factor in lung protection. Cd instillation caused dose- and time-dependent changes in the respiratory pattern measured by plethysmography (Penh), and significant increases in lactate dehydrogenase (LDH) activity as well as macrophage and neutrophil counts in bronchoalveolar lavage fluids. HS preconditioning induced Hsp overexpression and reduced the Penh (-30%), LDH (-25%), and neutrophil (-55%) responses to subsequent administration of the highest Cd doses (50 and 100 microg) in wild-type mice. HSF1 deficiency abolished the HS response and its protective effect. In the absence of preconditioning, Hsf1(-/-) mice exhibited higher values of Penh (+70%) and LDH activity (+42%) compared with wild-type animals when exposed to the lowest Cd doses. Higher macrophage (+80%) and neutrophil counts (+115%) were recorded whatever the dose. Western blot analyses indicated that lung protection might be related to the kinetics of HSF1-dependent Hsp70 expression. Altogether, our data demonstrate that HS response elicited both by prior HS and by Cd itself moderates pulmonary injuries due to Cd instillation, and that HSF1 is a major mediator in this protection. [less ▲]

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See detailAcetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
Ambrosini, A.; Pierelli, F.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (2003), 23(2), 75-8

Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2 ... [more ▼]

Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2+-channels on motor axons controlling stimulation-induced acetylcholine release. Acetazolamide, which is thought to ameliorate ion channel function, was shown effective in familial hemiplegic migraine and episodic ataxia type 2, both of which are associated with mutations of the neuronal Ca2+-channel gene CACNA1A, as well as in aura status. We treated therefore in an open pilot study five non-hemiplegic migraineurs showing mild SFEMG abnormalities with acetazolamide for several weeks. This was followed by a normalization of SFEMG recordings in all patients and by clinical improvement in four. These results support the assumption that the subclinical impairment of neuromuscular transmission found in certain migraineurs might be due to dysfunctioning Ca2+-channels. [less ▲]

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See detailNasal aspergillosis associated with an impacted canine tooth in a Belgian shepherd dog
Saunders, J.; Clercx, Cécile ULg; Zonderland, J.L. et al

in Vlaams Diergeneeskundig Tijdschrift (2003), 72(6), 396-398

A 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left ... [more ▼]

A 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left nasal cavity with caudal displacement of the tooth root. Rhinoscopy demonstrated the presence of fungal colonies. The impacted tooth was surgically removed and the nasal cavity flushed with enilconazole 1%. No recurrence was observed during a follow-up period of two years. [less ▲]

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See detailProlonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage.
Hermanns-Lê, Trinh ULg; Paquet, Philippe ULg; Nikkels, Arjen ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 361-365

Factor-XIIIa-positive dendrocytes belong to the monocyte-macrophage-dendrocyte (MMD) lineage which is considered to play a pivotal role in the skin response to the immune response modifier imiquimod. The ... [more ▼]

Factor-XIIIa-positive dendrocytes belong to the monocyte-macrophage-dendrocyte (MMD) lineage which is considered to play a pivotal role in the skin response to the immune response modifier imiquimod. The same cells are also boosted in low-grade graft-versus-host reaction (GVHR) with skin manifestations. Both conditions are characterized by specific epidermal damage. The aim of the present study was to compare them using immunohistochemistry to identify MMD subsets and other inflammatory cells in the dermis. We compared 3 cases of long-term (4, 9 and 11 months) imiquimod topical applications on normal skin, 25 low-grade GVHR controlled by immunosuppressive therapy and 25 control cases with normal skin. Compared to the normal dermis, cells of the MMD lineage were considerably boosted in the dermis of GVHR and at the imiquimod-treated sites. By contrast, only minimal accumulations of lymphocytes and Langerhans cells were disclosed in the dermis. The pattern of dermal infiltration by MMD cells was similar in GVHR and after imiquimod treatment. However, intraindividual differences in densities were obvious irrespective of the skin condition. In conclusion, there is great mimicry in the MMD involvement in the dermis during low-grade GVHR and after chronic applications of imiquimod. [less ▲]

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See detailChoice of an adjuvant for vaccination trials
Vermout, Sandy; Denis, M.; Losson, Bertrand ULg et al

in Annales de Médecine Vétérinaire (2003), 147(6), 393-401

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it ... [more ▼]

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it qualitatively. A number of tumors and infectious diseases could be treated with adjuvant preparations that would adequately intensify and modulate specific immune response; in particular, the possibility to specifically induce a Th1 response seems to be of paramount importance for the prevention and for the cure of these diseases. Furthermore, these adjuvants must be as safe as possible, not only for commercial applications, but also in the respect of laboratory animals' welfare. This review describes the different adjuvants presently used in vaccinology, classifying them following their chemical nature and presenting for each category the knowledge concerning their activity and toxicity. [less ▲]

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See detailHybrid magnetic equivalent circuit - finite element modelling of transformer fed electrical machines
Gyselinck, Johan; Dular, Patrick ULg; Legros, Willy ULg et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2003), 22(3), 643-658

This paper deals with the modelling of transformer supply in the two-dimensional (2D) finite element (FE) simulation of rotating electrical machines. Three different transformer models are compared The ... [more ▼]

This paper deals with the modelling of transformer supply in the two-dimensional (2D) finite element (FE) simulation of rotating electrical machines. Three different transformer models are compared The reference one is based on two 2D FE models, considering a cross-section either parallel or perpendicular to the laminations of the magnetic core. The parameters of the two other transformer models, a magnetic equivalent circuit and an electrical equivalent circuit, can be derived from the reference model Particular attention is paid to some common features of the transformer models, e.g. with regard to the inclusion of iron losses. The three models are used in the 2D FE simulation of the steady-state load operation and the starting from stand-still of an induction motor. [less ▲]

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See detailL’implication dans la recherche clinique : un chemin vers la psychanalyse
Naziri, Despina ULg

in Revue Belge de Psychanalyse (2003), 40(printemps), 3-24

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon ... [more ▼]

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon travail sur le recours répétitif à l’avortement en explicitant mon cheminement, tant au niveau de la pensée que de l’expérience, et en reprenant quelques repères de mon itinéraire personnel. [less ▲]

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See detailApport à la connaisance du genre Rhizophagus Herbst, 1793 (Coleoptera: Clavicornia Monotomidae) en région wallonne (Belgique)
Thieren, Yves; Fagot, Jean ULg; Lhoir, Jonathan et al

in Notes Fauniques de Gembloux (2003), 50

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations ... [more ▼]

During a trapping year in two hardwood forests of Walloonia, the Rhizophagus reveale to be the most abundant saproxylic beetles. The authors give comments on the different species met, on the relations between species and trapping methods and on the species activity during the six months trapping. Waiting for an exhaustive revision of the genera, a primary point is made on the Rhizophagus in Belgium and a prime list is given with a lot of ethological considerations. [less ▲]

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See detailMismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects.
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Scantamburlo, Gabrielle ULg et al

in Human Psychopharmacology (2003), 18(3), 201-5

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immediate vicinity of the primary auditory cortex and with possible contribution from the frontal cortex. However, few data are available concerning the influence of neurotransmitter systems on the MMN. In this study, the relationship between both noradrenergic and dopaminergic systems and the MMN were investigated in 34 healthy volunteers. Noradrenergic and dopaminergic activities were assessed with the apomorphine and clonidine challenge tests. The results showed no significant relationship between either growth hormone (GH) responses to apomorphine or clonidine and the MMN amplitude or latency. Therefore, this study does not demonstrate the implication of dopaminergic and noradrenergic activities as assessed by GH response to apomorphine and clonidine for the generation and/or the modulation of the MMN. However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN. [less ▲]

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See detailThree years of free-air CO2 enrichment (POPFACE) only slightly affects profiles of light and leaf characteristics in closed canopies of Populus.
Gielen, B; Liberloo, M; Bogaert, Jan ULg et al

in Global Change Biology (2003), 9(7), 1022-1037

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See detailApproximation algorithms for the design of SDH/SONET networks
Brauner, Nadia; Crama, Yves ULg; Finke, Gerd et al

in RAIRO : Operations Research = Recherche Opérationnelle (2003), 37(4, OCT-DEC), 235-247

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this ... [more ▼]

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this problem efficiently in practice, fast greedy algorithms and a tabu-search method are proposed and analyzed by means of an experimental study. [less ▲]

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See detailA recombinant 31.5 kDa keratinase and a crude exo-antigen from Microsporum canis fail to protect against a homologous experimental infection in guinea pigs.
Descamps, Frederic F; Brouta, Frederic; Vermout, Sandy M et al

in Veterinary Dermatology (2003), 14(6), 305-312

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three ... [more ▼]

A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three times at two-week intervals with either the keratinase, the exo-antigen or the adjuvant alone. Cutaneous challenge was performed blindly. Both humoral and cellular-specific immune responses to M. canis antigens were evaluated every 14 days, while a blind evaluation of clinical lesion development and fungal persistency in skin were monitored weekly. Vaccination induced very high and significant (P < 0.01) antibody responses towards both antigens. High cell-mediated immune responses to both immunogens were also induced by vaccination. After challenge, however, scores reflecting the severity of dermatophytic lesions did not differ significantly between vaccinated and control groups at any time after challenge. These results suggest that, in the guinea pig, the induction of specific immune responses against the M. canis-secreted antigens used in this study are not protective against challenge exposure. [less ▲]

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See detailRéférences et issues des accouchements au Kivu, République démocratiquedu Congo
Mugisho, E; Dramaix, M; Porignon, Denis ULg et al

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2003), 51(2), 237-244

BACKGROUND: The process of referral between the first and the second level of the health system in the Democratic Republic of Congo is poorly understood. This report intends to study the association ... [more ▼]

BACKGROUND: The process of referral between the first and the second level of the health system in the Democratic Republic of Congo is poorly understood. This report intends to study the association between the referral and the hospital perinatal outcomes. METHODS: Delivery outcomes in a retrospective cohort of 1162 women admitted between June 95 and May 96, in two referral hospitals in Kivu were analyzed according to the referral status and the women's characteristics. RESULTS: Forty-three percent (n=492)of women admitted, corresponding to 2.3% of expected pregnant women, were referred. Referred women had higher risks of obstetrical complications (OR=2.0; CI95%: 1.3-3.1) and intervention (OR=1.5; CI95%: 1.0-2.3) and similar risks of low birth weight and perinatal mortality. Women with complications during the antenatal period had a double risk of intervention and perinatal mortality. The risk of obstetrical intervention was lower when women had attended 2 visits (OR=0.5; CI95%: 0.3-0.8); the risk of low birth weight was lowest only for mothers who had attended one visit (OR=0.5; CI95%: 0.3-0.9). Distance > or =90 minutes walking from home to hospital raised the risk of obstetrical complication (OR=1.7; CI95%: 1.1-2.5), the risk of obstetrical intervention (OR=1.5; CI95%: 1.0-2.1), and the risk of perinatal mortality (OR=1.6; CI95%: 1.0-2.7). Late admission raised the risk of perinatal mortality (OR=1.8; CI95%: 1.2-2.9) and lowered the risk of obstetrical complication (OR=0.7; CI95%: 0.5-1.0). Part payment of care was associated with higher risks of low birth weight (OR=1.9; CI95%: 1.3-2.9), perinatal mortality (OR=2.2; CI95%: 1.4-3.5) and obstetrical intervention (OR=2.4; CI95%: 1.7-3.4). CONCLUSION: These results suggest a deficit of referred cases considering that 15% of pregnant women in the area covered by the referral hospitals should have been referred. They confirm the negative influence of economic and geographic constraints on the delivery outcomes. They point out the relevance of making reorganization of the referral system a priority. [less ▲]

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See detailLes ateliers du Matériel: pivots de la diffusion de l'organisation rationnelle au sein de la Société Nationale des Chemins de fer Belges, 1910-1940
Geerkens, Eric ULg

in Revue d'Histoire des Chemins de Fer (2003), (28-29), 207-221

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d ... [more ▼]

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d'expérimentation, le point de diffusion de ces méthodes vers d'autres services de la société, mais aussi vers les constructeurs belges de matériel roulant. L'introduction du système de rémunération Rowan à l'atelier central de Malines (principal atelier du matériel du réseau belge) peut être tenu pour le point de départ de l'adoption de méthodes d'organisation rationnelle, dans la mesure où elle impliquait une première forme d'étude systématique du travail ouvrier. Au lendemain de la Première Guerre, une nouvelle organisation du travail d'inspiration taylorienne et son corollaire indispensable - une comptabilité industrielle - vont être introduits dans les ateliers de moyenne réparation des locomotives. Associée initialement à une concentration des ateliers, la taylorisation ne va cesser de progresser. L'adoption du travail à la chaîne pour le placement de freins à air sur ses wagons a constitué une des innovations majeures dans l'organisation du travail à la SNCB. Forte de cette expérience, la SNCB va étendre le travail à la chaîne à d'autres travaux exécutés par le service du Matériel, puis à certaines activités d'autres services. Ainsi cette technique, adoptée pour une opération ponctuelle, va être appliquée aux travaux récurrents de réparation et d'entretien du matériel roulant. Au service de l'Exploitation, la recherche d'un équilibre optimal entre les tâches successives, déterminant majeur du rendement dans le travail à la chaîne, va fournir le principe d'une organisation nouvelle du triage des wagons; de même, les travaux d'entretien des voies vont être réorganisés de manière à les faire exécuter suivant certains principes du travail à la chaîne. La baisse du trafic de marchandises et la dégradation de ses résultats financiers au début des années '30 vont amener la SNCB à approfondir la rationalisation des différents travaux, par une combinaison de techniques déjà éprouvées et de procédures nouvelles; la gestion très centralisée des ateliers va s'appuyer sur deux techniques particulières: les plannings et le contrôle budgétaire. Par une modification de ses principes d'adjudication, la société va aussi imposer le travail à la chaîne, puis le planning, à ses fournisseurs de matériel roulant, amenant ainsi une modernisation de leurs méthodes de travail. L'adoption et la diffusion des méthodes d'organisation a impliqué une très forte centralisation des structures administratives, dont une illustration est donnée par le service d'entretien des wagons, où tous les ateliers sont dirigés par le service central des wagons de la direction du Matériel. Au début de la Seconde Guerre, les limites de cette centralisation vont être perçues par les fonctionnaires dirigeants qui avaient introduit les méthodes d'organisation tayloriennes. Il en résultera une décentralisation des responsabilités; son abandon au lendemain du conflit marque toutefois le retour à une centralisation taylorienne dont les effets se feront sentir pendant plusieurs décennies. [less ▲]

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See detailIncreased electron donor and electron acceptor characters enhance the adhesion between oil droplets and cells of Yarrowia lipolytica as evaluated by a new cytometric assay
Aguedo, Mario ULg; Waché, Y.; Mazoyer, V. et al

in Journal of Agricultural and Food Chemistry (2003), 51(10), 3007-3011

The adhesion of methyl ricinoleate droplets to cells of the yeast Yarrowia lipolytica was investigated. A new cytometric method, relying on the double staining of fatty globules with Nile Red and of cells ... [more ▼]

The adhesion of methyl ricinoleate droplets to cells of the yeast Yarrowia lipolytica was investigated. A new cytometric method, relying on the double staining of fatty globules with Nile Red and of cells with Calcofluor, enabled us to quantify methyl ricinoleate droplet adhesion to cells precultured on a hydrophilic or on a hydrophobic carbon source. In this last case, droplet adsorption was enhanced and a MATS (microbial adhesion to solvents) test revealed that this increase was due to Lewis acid-base interactions and not to an increase in the hydrophobic properties of the cell surface. These preliminary results demonstrate that the developed cytometric method is promising for various applications concerning the study of interactions between microorganisms and an emulsified hydrophobic substrates. [less ▲]

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See detailHC gp-39 gene is upregulated in glioblastomas.
Shostak, Kateryna ULg; Labunskyy, Vyacheslav; Dmitrenko, Vladimir et al

in Cancer Letters (2003), 198(2), 203-10

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression ... [more ▼]

Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression (SAGE). Analysis revealed HC gp-39 among the genes with the most pronounced changes of expression in tumor cells. Northern hybridization confirmed the results of computer analysis and showed that enhanced expression of the HC gp-39 gene was mainly in GBMs and occasionally in anaplastic astrocytomas. Neither SAGE nor Northern analysis revealed the presence of HC gp-39 mRNA in the glioblastoma cell line, thus the detection of increased quantities of this mRNA in GBMs may be associated with activated macrophages. Since the numbers of infiltrating macrophages and small vessel density are higher in glioblastomas than in anaplastic astrocytomas or astrocytomas, the HC gp-39 gene can be used as a molecular marker in the analysis of malignant progression of astrocytic gliomas. [less ▲]

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See detailIntroduction of australian diploid cotton genetic variation into upland cotton
Ahoton, L.; Lacape, Jm.; Baudoin, Jean-Pierre ULg et al

in Crop Science (2003), 43(6), 1999-2005

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See detailCorrelation between Paired Responses Confirms the Existence of a Positive Ephaptic Feedback in Central Synapses
Koulchitsky, Stanislav ULg; (Kulchitsky); Maximov, V. V. et al

in Doklady Biological Sciences (2003), 389(1), 102-104

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See detailDetuning effects on the mazer
Martin, John ULg; Bastin, Thierry ULg

in Physicalia Magazine (2003), 25

A short review of the theoretical studies of the cold atom micromaser (mazer) is presented. Existing models are then improved by considering more general working conditions. Especially, the mazer physics ... [more ▼]

A short review of the theoretical studies of the cold atom micromaser (mazer) is presented. Existing models are then improved by considering more general working conditions. Especially, the mazer physics is investigated in the situation where a detuning between the cavity mode and the atomic transition frequency is present. Interesting new effects are pointed out. Especially, it is shown that the cavity may slow down or speed up the atoms according to the sign of the detuning and that the induced emission process may be completely blocked by use of a positive detuning. The transmission probability of ultracold atoms through a micromaser is also studied and we generalize previous results established in the resonant case. In particular, it is shown that the velocity selection of cold atoms passing through the micromaser can be very easily tuned and enhanced using a nonresonant field inside the cavity. [less ▲]

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See detailElectronic interface design for an electrically floating micro-disc
Gindila, Mircea V.; Kraft, Michael ULg

in Journal of Micromechanics and Microengineering (2003), 13(4), 11-16

The design of an electronic interface for an electrically floating micro-disc is presented. The system, based on a second order electromechanical – modulator, can be used as a multi-axis capacitive ... [more ▼]

The design of an electronic interface for an electrically floating micro-disc is presented. The system, based on a second order electromechanical – modulator, can be used as a multi-axis capacitive accelerometer with the proof mass levitated by electrostatic forces. A synchronous detection scheme, used to sense the position of the proof mass, has been designed, simulated in PSpice TM and successfully implemented on a PCB. The interface contains a differential pick-off with no ohmic connection to the proof mass, which distinguishes the circuit from typical sensing circuits for MEMS capacitive accelerometers. A noise analysis of the pick-off circuit was performed, and an electronic equivalent model of the sensing circuit has been developed and used to analyse the linearity of its transfer function. The linearity of the sensing circuit was confirmed experimentally using the PCB implementation. [less ▲]

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See detailLarval development of Myzostoma cirriferum (Myzostomida)
Eeckhaut, I.; Fievez, Laurence ULg; Muller, M. C.

in Journal of Morphology (2003), 258

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and ... [more ▼]

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and the metatrochophore. The protrochophore is a ball-shaped larva present in culture from 18-48 h after egg laying. It has no internal organs and its body is made of three cell types: covering cells and ciliated cells that are external and surrounded by a cuticle, and resting cells that fill the blastocoel. The trochophore is a pear-shaped larva that develops 20-72 h after egg laying; the body includes the same three cell types as the previous stage. The metatrochophore is a pear-shaped larva that develops between 40 h and 14 days and is characterized by the presence of two bundles of four chaetae. When fully developed, the metatrochophore has a digestive system (made of a pharynx, an esophagus, and a blind digestive pouch), two pairs of protonephridia, and a nervous system composed of a supraesophageal ganglion, circumesophageal connectives, and dorsal and ventral nerves. Metamorphosis generally occurs 7 days after egg laying. At that time, the metatrochophore loses its chaetae and becomes pleated ventrally. This ultrastructural analysis suggests that chaetae and the five ventral longitudinal nerve cords of M. cirriferum metatrochophores are homologous structures to those observed in some polychaete trochophores. Coupled with recent phylogenetic analyses, where the Myzostomida are placed outside the Annelida, homologies between myzostomid and polychaete larvae support the view that a trochophore appeared early during the spiralian evolution [less ▲]

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See detailLes apports du projet Johns Hopkins dans la statistique du non-marchand
Mertens de Wilmars, Sybille ULg

in Non Marchand : Management, Droit et Finance (2003), (11), 29-38

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See detailLa Vie de saint Lambert du chanoine Nicolas (ca 1145) et l’élection du prince-évêque Henri de Leez (1145-1162)
Adam, Renaud ULg

in Bulletin de l'Institut Archéologique Liégeois (2003), 111

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See detailSolar-blind diamond detectors for LYRA, the solar VUV radiometer on board PROBA II
Benmoussa, A.; Hochedez, J. F.; Schmutz, W. K. et al

in Experimental Astronomy (2003), 16(3), 141-148

Fabrication, packaging and experimental results on the calibration of metal-semiconductor-metal (MSM) photodetectors made on diamond are reported. LYRA (Lyrnan-alpha RAdiometer onboard PROBA-2) will use ... [more ▼]

Fabrication, packaging and experimental results on the calibration of metal-semiconductor-metal (MSM) photodetectors made on diamond are reported. LYRA (Lyrnan-alpha RAdiometer onboard PROBA-2) will use diamond detectors for the first time in space for a solar physics instrument. A set of measurement campaigns was designed to obtain the XUV-to-VIS responsivity of the devices and other characterizations. The measurements of responsivity in EUV and VUV spectral ranges (40-240 nm) have been carried out by the Physkalisch-Technische Bundesanstalt (PTB) in Germany at the electron storage ring BESSY II. The longer wavelength range from 210 to 1127 nm was measured with monochromatic light by using a Xe-lamp at IMO-IMOMEC. The diamond detectors exhibit a photoresponse which lie in the 35-65 mA/W range at 200 nm (corresponding to an external quantum efficiency of 20-40%) and indicate a visible rejection ratio (200-500 nm) higher than four orders of magnitude. [less ▲]

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See detailAn intervention study to enhance postoperative pain management.
Bardiau, Françoise ULg; Taviaux, Nicole F; Albert, Adelin ULg et al

in Anesthesia and Analgesia (2003), 96(1), 179-85

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery ... [more ▼]

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery departments were involved. In this study we sought to evaluate the results of a continuous quality improvement program by defining quality indicators and using quality tools. A quality program in accordance with current standards of acute pain treatment (multimodal) was worked out to enhance pain relief for all surgical inpatients. A survey of nurses' knowledge with regard to postoperative pain was conducted, and a visual analog scale (VAS) was introduced to assess pain intensity. Both nurses and physicians became familiar with evidence-based guidelines concerning postoperative pain. The entire process was monitored in three consecutive surveys and enrolled 2383 surgical inpatients. Pain indicators based on VAS and analgesic consumption were recorded during the first 72 postoperative hours. After a baseline survey about current practices of pain treatment, a nurse-based, anesthesiologist-supervised APS was implemented. The improvement in pain relief, expressed as VAS scores, was assessed in two further surveys. A quality manual was written and implemented. A major improvement in pain scores was observed after the APS inception (P < 0.001). IMPLICATIONS: The implementation of an acute pain service, including pain assessment by a visual analog scale, standard multimodal pain treatment, and continuous quality evaluation, improved postoperative pain relief. Establishing teams of surgeons, anesthesiologists, and nurses is the prerequisite for this improvement. [less ▲]

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See detailLa peau de l'acromégale.
Hermanns-Lê, Trinh ULg; QUATRESOOZ, Pascale ULg; Arrese Estrada, Jorge ULg et al

in Dermatologie Actualité (2003), 75

L'acromégalie est l'expression clinique d'une hypersécrétion chronique de l'hormone de croissance dont la source est, dans la plupart des cas, un adénome hypophysaire. Son diagnostic est souvent posé ... [more ▼]

L'acromégalie est l'expression clinique d'une hypersécrétion chronique de l'hormone de croissance dont la source est, dans la plupart des cas, un adénome hypophysaire. Son diagnostic est souvent posé tardivement, car les signes cliniques se développent de façon insidieuse. [less ▲]

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See detailLe médecin, la trousse et le livre dans le monde gréco-romain
Marganne, Marie-Hélène ULg

in Papyrologica Lupiensia (2003), 12

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See detailReal-time reconstruction of the vertical electron density distribution from GPS TEC measurements
Stankov, Stanimir; Warnant, René ULg; Jodogne, Jean-Claude

in Acta Geodaetica et Geophysica Hungarica (2003), 38(4), 377-388

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See detail'Aangewaaid uit een vreemd land': de westerse poëzie van G.J. Resink
Steyaert, Kris ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2003), 119(4), 279-299

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have ... [more ▼]

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have very much focused on what they perceive to be 'eastern' elements in Resink's oeuvre. I maintain that this has resulted in a one-sided interpretation, neglecting the underlying western, and in particular Dutch, tradition in many of Resink's poems. This article demonstrates the different ways in which Resink drew on the principles and literary output of the Eighties Movement, and how his formal experiments gain in significance when set against the work of poets like Perk, Kloos, and Dèr Mouw. The general view on Resink's later work as being inferior to his earlier poetry is shown to be the result of unwarranted preconceptions. [less ▲]

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See detailAbsolute and relative quantification : beyond mutually exclusive word classes.
Brems, Lieselotte ULg; Davidse, Kristin

in Belgian Journal of English Language and Literatures. New Series (2003), 1

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See detailMarocains de Belgique : du travailleur immigré au citoyen transnational
Bousetta, Hassan ULg; Martiniello, Marco ULg

in Hommes & Migrations (2003), 1242(Mars-Avril), 94-106

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See detailImage analysis characterization of multi-walled carbon nanotubes
Gommes, Cédric ULg; Blacher, Silvia ULg; Masenelli-Varlot, Karine et al

in Carbon (2003), 41(13), 2561-2572

An original image analysis method is presented to characterize multi-walled carbon nanotubes from transmission electron microscopy images. The analysis is performed in three steps: (i) image preprocessing ... [more ▼]

An original image analysis method is presented to characterize multi-walled carbon nanotubes from transmission electron microscopy images. The analysis is performed in three steps: (i) image preprocessing in order to isolate the nanotubes from the background, (ii) image segmentation, aiming at keeping only the measurable sections of nanotubes, and finally (iii) tube characteristics measurement. The measurement is based on a Lambert-like electron absorption law and is performed on the original gray level image itself. Two geometrical and one physical characteristics are determined for each tube, namely, its outer and inner radius and a linear electron absorption coefficient. The method is illustrated by comparing a pristine and an annealed carbon nanotube samples. The compaction of the tube walls during annealing is shown to result from a lowering of the external radius while the inner radius is left unchanged. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailChorionic expression of heterogeneous products of the PAG (Pregnancy-Associated Glycoprotein) gene family secreted in vitro throughout embryonic and foetal development in the pig
Szafranska, B.; Panasiewicz, G.; Majewska, M. et al

in Reproduction Nutrition Development (2003), 43(6), 497-516

Porcine PAG (pPAG) are placental products of a multigene family that is strongly expressed in the chorionic epithelium (trophoblast and trophectoderm). The objective of this study was to define a pattern ... [more ▼]

Porcine PAG (pPAG) are placental products of a multigene family that is strongly expressed in the chorionic epithelium (trophoblast and trophectoderm). The objective of this study was to define a pattern of the pPAG proteins, secreted in vitro by chorionic explants harvested on 16-77 days of pregnancy. Trophoblastic and trophectodermal explants were collected from pregnant (PR) gilts (n = 27) and used for protein in vitro production (8-261 h). Endometrial explants of luteal-phase gilts (E10, n = 4) and pseudopregnant gilts (PsE, n = 2) were used as negative controls for protein immunoblotting. Proteins (PR, E10, PsE) were isolated mainly from incubation media, fractionated, dialysed and separated by SDS-PAGE. Heterogeneous Western blotting with various polyclonal anti-PAG sera raised against bovine or ovine antigens (anti-bPAG, or anti-oPAG) initially identified the pPAG proteins. Such blotting of fractionated chorionic proteins allowed for the isolation of porcine antigens that were employed as immunogens to raise several homologous antisera (anti-pPAG). Crude antisera were adsorbed on endometrial extracts or proteins of non-PR pigs, to remove non-relevant antibodies. The patterns of pPAG proteins secreted in Vitro varied throughout pregnancy (35-72 kDa). During implantation, similar to43 kDa (Day 16) or similar to68.1 kDa (Days 17-25) pPAG proteins were detected. During placentation and as pregnancy advanced (Days 31-77), similar to72.3 kDa pPAG proteins were observed. The secretions of parallel multiple smaller proteins (35.4-47.2 kDa), presumably, as forms of processed pPAG precursors, increased with the progress of gestation. In conclusion, the pPAG protein family plays a very important role during implantation, placenta formation and embryonic/foetal development in the pig. [less ▲]

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See detailCes nombres que l'on dit "imaginaires".
Rosseel, H.; Schneider, Marguerite ULg

in Petit X (2003), 63

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See detailRadiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL : étude prospective de phase II
Zouhair, A; COUCKE, Philippe ULg; Azria, D. et al

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (2003), 7

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods ... [more ▼]

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. – Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43–81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI) * Auteur correspondant. Adresse e-mail : abderrahim.zouhair@chuv.hospvd.ch (A. Zouhair). Cancer/Radiothérapie 7 (2003) 231–236 www.elsevier.com/locate/canrad © 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits réservés. doi:10.1016/S1278-3218(03)00041-6 was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam RT 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. – According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0–16). No grade 4 toxicity was observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, and actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion. – The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fractions per week) is feasible with local control rates comparable to that of published data. Acute RT-related morbidity is acceptable. [less ▲]

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See detailLa conception d'une exposition : du schéma programmatique à sa mise en espace
Drouguet, Noémie ULg; Gob, André ULg

in Culture et Musées (2003), 2

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