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See detailWiktor stent for treatment of chronic total coronary artery occlusions: short- and long-term clinical and angiographic results from a large multicenter experience.
Anzuini, A.; Rosanio, S.; Legrand, Victor ULg et al

in Journal of the American College of Cardiology (1998), 31(2), 281-8

OBJECTIVES: This study reports the first multicenter experience with the Wiktor coil stent for treatment of chronic total coronary artery occlusions (CTOs). BACKGROUND: Percutaneous transluminal coronary ... [more ▼]

OBJECTIVES: This study reports the first multicenter experience with the Wiktor coil stent for treatment of chronic total coronary artery occlusions (CTOs). BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) of CTO is associated with very high restenosis and reocclusion rates. Coronary stenting has been proposed as a means of improving outcome. However, the Wiktor device for CTOs has never been tested in a large patient sample. METHODS: From January 1993 to December 1996, 89 patients with 91 CTOs underwent Wiktor stent implantation after successful PTCA. The post-stenting regimen consisted of warfarin (Coumadin) plus aspirin in the initial 49 patients (55%) and aspirin plus ticlopidine in 40 patients (45%). RESULTS: Stenting was successful in 87 patients (98%). At 1 month, 6% of patients had subacute stent thrombosis, 3% had a major bleeding event, and 1% had access-site complications. Subacute stent thrombosis showed univariate association with warfarin therapy (p = 0.009). Angiographic follow-up was obtained in 76 (93%) of 82 eligible patients. The restenosis rate was 32%, including 4% reocclusions. By multiple logistic regression analysis, restenosis was independently associated with multiple stents (adjusted odds ratio [OR] 27.67, 95% confidence interval [CI] 4.25 to 79.95, p = 0.0008) and increasing values of occlusion length (adjusted OR 1.23, 95% CI 1.09 to 1.39, p = 0.001). Freedom from death, myocardial infarction or stented vessel revascularization was 87% and 72% at 1 and 3 years, respectively. CONCLUSIONS: Short- and long-term clinical and angiographic outcomes are favorable in patients undergoing Wiktor stent implantation in CTO. Further technical improvement is needed to reduce the restenosis rate in patients with long lesions and multiple stents. [less ▲]

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See detailBlock and random copolymers of ε-caprolactone
Duda, Andrzej; Biela, Tadeusz; Libiszowski, Jan et al

in Polymer Degradation & Stability (1998), 59(1-3), 215-222

Conditions of the living homopolymerization of epsilon-caprolactone (CL), lactides (LA), and of the homo-oligomerization of gamma-butyrolactone (BL) are briefly described. Then block and random ... [more ▼]

Conditions of the living homopolymerization of epsilon-caprolactone (CL), lactides (LA), and of the homo-oligomerization of gamma-butyrolactone (BL) are briefly described. Then block and random copolymerizations of CL with LA are shortly reviewed. The microstructure of the resulting copolyesters in relation to some peculiarities of these processes is discussed in more detail. It is also shown that the otherwise 'non-polymerizable' BL does form high molecular weight copolymers with CL, containing up to 50 mol% repeating units derived from BL. Their molecular weight is controlled by the concentrations of the consumed comonomers and the starting concentration of the initiator. NMR and DSC data indicate the random structure of copolymers. TGA traces of the BL/CL copolymers show that the presence of the gamma-oxybutyryl repeating units randomly distributed within the poly(CL) chains improves the thermal stability of the latter. [less ▲]

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See detailAutocrine role of TGFbeta1 in adrenal.
Langlois, D.; Leroy, Céline ULg; Penhoat, A. et al

in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (1998), 30(6-7), 411-415

Three main criteria are required to postulate that a factor has an autocrine action in any cell: presence of receptors and biological effects of the factor; local production which must be regulated by ... [more ▼]

Three main criteria are required to postulate that a factor has an autocrine action in any cell: presence of receptors and biological effects of the factor; local production which must be regulated by physiological signals and the inhibition of its secretion or action should cause effects opposite to those caused by the exogenous factor. In adrenal cells, transforming growth factor beta1 (TGFbeta1) fulfilled these criteria: 1) Adrenal cells possess TGFbeta1 receptors and this factor regulates the expression of adrenal cell specific genes, including ACTH and angiotensin II (AngII) receptors and several steroidogenic enzymes, leading to changes in the steroidogenic responsiveness; 2) Adrenal cells express and secrete TGFbeta1 and its secretion is regulated by the two adrenal specific hormones ACTH and AngII; 3) The blockade of TGFbeta1 protein synthesis by an antisense oligonucleotide produces changes in adrenal cell functions opposed to those induced by the exogenous factor. [less ▲]

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See detailImpala: A Simple Restraint Field To Simulate The Biological Membrane In Molecular Structure Studies
Ducarme, P.; Rahman, M.; Brasseur, Robert ULg

in Proteins-Structure Function and Bioinformatics (1998), 30(4), 357-71

The lipid bilayer is crucial for the folding of integral membrane proteins. This article presents an empirical method to account for water-lipid interfaces in the insertion of molecules interacting with ... [more ▼]

The lipid bilayer is crucial for the folding of integral membrane proteins. This article presents an empirical method to account for water-lipid interfaces in the insertion of molecules interacting with bilayers. The interactions between the molecule and the bilayer are described by restraint functions designed to mimic the membrane effect. These functions are calculated for each atom and are proportional to the accessible surface of the latter. The membrane is described as a continuous medium whose properties are varying along the axis perpendicular to the bilayer plane. The insertion is analyzed by a Monte Carlo procedure applied to the restraint functions. The method was successfully applied to small alpha peptides of known configurations. It provides insights of the behaviors of the peptide dynamics that cannot be obtained with statistical approaches (e.g., hydropathy analysis). [less ▲]

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See detailPathological investigations on guillemots (Uria aalge) stranded on the Belgian coast during the winter of 1993-94
Jauniaux, Thierry ULg; Brosens, L.; Meire, P. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(14), 387-390

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were ... [more ▼]

Pathological investigations were carried out on 67 guillemots (Uria aalge) washed up on the Belgian coast between November 1993 and March 1994. Emaciation and acute haemorrhagic gastroenteropathy were observed in more than 70 per cent of the birds. There was no statistical relationship between the level of oil contamination and the severity of the lesions. Differences in bodyweight were accounted for by age, sex, emaciation, and acute haemorrhagic gastroenteropathy. The birds had a severe weight deficit but the concentrations of pollutants were below acutely toxic levels. [less ▲]

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See detailInduction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury.
Hopkins, D. A.; Plumier, Jean-Christophe ULg; Currie, R. W.

in Experimental Neurology (1998), 153(2), 173-83

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular ... [more ▼]

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular metabolic stress. In this study, we examined the distribution of Hsp27 in the rat medulla oblongata by means of immunohistochemistry after the vagus nerve was cut or crushed. After vagal injury, rats were allowed to survive for 6, 12, 24 h, 2, 4, 7, 10, 14, 30, or 90 days. Vagus nerve lesions resulted in a time-dependent up-regulation of Hsp27 in vagal motor and nodose ganglion sensory neurons that expressed Hsp27 constitutively and de novo induction in neurons that did not express Hsp27 constitutively. In the dorsal motor nucleus of the vagus nerve (DMV) and nucleus ambiguus, the levels of Hsp27 in motor neurons were elevated within 24 h of injury and persisted for up to 90 days. Vagal afferents to the nucleus of the tractus solitarius (NTS) and area postrema showed increases in Hsp27 levels within 4 days that were still present 90 days postinjury. In addition, increases in Hsp27 staining of axons in the NTS and DMV suggest that vagus nerve injury resulted in sprouting of afferent axons and spread into areas of the dorsal vagal complex not normally innervated by the vagus. Our observations are consistent with the possibility that Hsp27 plays a role in long-term survival of distinct subpopulations of injured vagal motor and sensory neurons. [less ▲]

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See detailIncreased aortic compliance maintains left ventricular performance at lower energetic cost
Kolh, Philippe ULg; LAMBERMONT, Bernard ULg; GERARD, P et al

in European Heart Journal (1998), 19

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See detailDu Brut au Merlin: le fils du diable et les incertitudes génériques
Combes, Annie ULg

in Cahiers de Recherches Médiévales (XIIIe-XVe siècles) (1998), V

Le personnage de Merlin est à la base d'un récit au genre énigmatique, hybride, qui associe pour la première fois, et dans une certaine liberté, la prose et la fiction.

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See detailIs the woodmouse (Apodemus sylvaticus) of sicily a distinct species?
Michaux, Johan ULg; Sara, Maurizio; Libois, Roland ULg et al

in Belgian Journal of Zoology (1998), 128(2), 211-214

[No abstract available]

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See detailbébé prématuré, bébé particulier ? Quel suivi développemental ?
Battisti, Oreste ULg; François, A.; Bertrand, J. M. et al

in Archives de Pédiatrie (1998), 5

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See detailLocalisation de la laminine, fibronectine, de la E-cadhérine et des intégrines dans l’endomètre et l’endométriose
BELIARD, Aude ULg; Donnez, J; Nisolle, Michelle ULg et al

in Reproduction Humaine et Hormones (1998), 2

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See detailLe cartilage articulaire peut-il se régénérer ? (1ère partie)
Henrotin, Yves ULg; Reginster, Jean-Yves ULg

in Le Généraliste (1998), 414

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See detailDesign of an axial mechanical gas seal with self-acting lift geometry
DOCQUIER, N.; NELIS, M.; Bozet, Jean-Luc ULg

in European Journal of Mechanical and Environmental Engineering [=EJMEE] (1998), 43(no4), 195-203

Cet article étudie le comportement d'un joint mécanique sans contact à faces radiales, doté d'un dispositif d'augmentation de portance. La répartition des pressions et des vitesses dans le film mince est ... [more ▼]

Cet article étudie le comportement d'un joint mécanique sans contact à faces radiales, doté d'un dispositif d'augmentation de portance. La répartition des pressions et des vitesses dans le film mince est établie grâce à l'équation de Reynolds résolue au moyen de différences finies. L'étude paramétrique des caractéristiques du joint est ensuite réalisée en vue d'en déduire des abaques de fonctionnement et, par la suite, une démarche cohérente de choix des dimensions. L'auteur présente donc tout d'abord le fonctionnement d'un joint mécanique à gaz et il en décrit la géométrie et les conditions de travail. Après avoir défini et justifié les hypothèses utilisées, il propose une mise en équation du problème et décrit le comportement du système d'étanchéité en régime au moyen des résultats obtenus. L'article présente finalement l'influence de la géométrie du joint et propose une méthode de dimensionnement. [less ▲]

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See detailComment je traite... un patient diabetique de type 2: le projet "DREAM" pour une meilleure collaboration medecin generaliste-medecin specialiste. Diabetes Reinforcement of Adequate Management.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(2), 58-62

Type 2 diabetes is an important public health problem because of its high prevalence and morbidity rate which both are associated with a considerable social and human cost. The general practitioner should ... [more ▼]

Type 2 diabetes is an important public health problem because of its high prevalence and morbidity rate which both are associated with a considerable social and human cost. The general practitioner should play a central role in the management of patients with type 2 diabetes and try to meet the therapeutic objectives. Main goals include reinforcement of early diagnosis, by a better screening of individuals at risk for type 2 diabetes, achievement of a good glycaemic control, through an optimized antidiabetic treatment, correction of associated risk factors as well as detection and treatment of disease complications. DREAM ("Diabetes Reinforcement of Adequate Management") is a pilot project which started in Liege area end 1997 for at least 2 years. It aims at improving the management of type 2 diabetic patients through a better free collaboration between general practitioners and diabetologists and the adhesion to an optimized therapeutic strategy. This ambitious project benefits from the valuable support of three pharmaceutical companies. [less ▲]

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See detailFinite Element Comparative Study of Ship Structural Details
Iwahashi, Y.; Sumi, Y.; Hu, T. et al

in Marine Structures (1998)

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See detailEléments pour une préhistoire transcendantale
de Villers Grand Champs, Bénédicte ULg

in Recherches Husserliennes (1998), 6

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See detailLe vétérinaire et les médicaments : cadre légal actuel
Gustin, Pascal ULg; Laurier, L.; Plume, C.

in Annales de Médecine Vétérinaire (1998), 142

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See detailDeux nouvelles espèces de Byssoloma Trev. (lichens Pilocarpaceae) d'Europe Occidentale et de Macaronésie
Sérusiaux, Emmanuël ULg

in Cryptogamie. Bryologie, Lichenologie (1998), 19

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See detail"Dans la langue de nos pères"
Rochette, Bruno ULg

in Byzantion : Revue Internationale des Etudes Byzantines (1998), 68

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See detailLe juste entre formalisme et substantialisme. Etude comparative des jugements émis par des Tunisiens et des Français à propos d’une pratique coutumière de justice corrective
Nachi, Mohamed ULg

in Science Information/Information sur les sciences sociales (1998), 37(4), 547-592

Dans cet article, l’auteur se propose d’étudier le sens de la justice à partir d’un « cas » empirique recueilli en Tunisie et soumis à l’appréciation et au jugement de Tunisiens mais aussi de Français ... [more ▼]

Dans cet article, l’auteur se propose d’étudier le sens de la justice à partir d’un « cas » empirique recueilli en Tunisie et soumis à l’appréciation et au jugement de Tunisiens mais aussi de Français. L’examen des différentes espèces de justice établies par Aristote conduit à préciser les contours du tanfîl en tant qu’institution de partage mettant en oeuvre des règles de justice distributive et à montrer en quoi il s’agit dune forme de justice corrective sui generis. Après avoir éclairci la question du rapport aux normes, à travers la notion d’invocation des normes, et la question de la qualification, en comparant qualification juridique et qualification ordinaire, l’article analyse les formes d’argumentation et de justification que les Tunisiens et les Français interrogés mobilisent pour faire valoir leurs sens de la justice. L’analyse révèle deux types principaux de concepts de justice distributive : celle dans laquelle la légalité et le formalisme occupent une place prépondérante et celle où la primauté est accordée au contenu, à la substance, de la règle de justice. Tandis que dans le premier type le juste se confond avec le légal, dans le second non seulement il s’en distingue mais peut même s’y opposer, car ce qui est légal peut être injuste. L’auteur montre en particulier, en partant de la trilogie du juste chez Ricœur, dune part, que le compromis requiert une place de premier plan, et d’autre part, que l’idée de justice ne peut trouver sa pleine signification que dans une posture intermédiaire entre le légal et le bon, entre le formel et le substantiel. [less ▲]

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See detailUltrastructure and cytochemistry of the early calcification site and of its mineralizing organic matrix in Paracentrotus lividus (Echinodermata: Echinoidea)
Amaye, Laurent; Compère, Philippe ULg; Dubois, Philippe

in Histochemistry & Cell Biology (1998), 110

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See detailAn association exists between bovine herpesvirus-4 seropositivity and abortion in cows.
Czaplicki, G.; Thiry, Etienne ULg

in Preventive Veterinary Medicine (1998), 33(1-4), 235-40

The prevalence of cattle seropositive to bovine herpesvirus-4 (BHV-4) is high in Belgium. In Belgian farms, clinical signs associated with BHV-4 infection essentially involve the genital tract and consist ... [more ▼]

The prevalence of cattle seropositive to bovine herpesvirus-4 (BHV-4) is high in Belgium. In Belgian farms, clinical signs associated with BHV-4 infection essentially involve the genital tract and consist mainly of postpartum metritis or metroperitonitis. The role of BHV-4 in abortion has not been definitively demonstrated but epidemiological and experimental facts suggest its involvement. A seroepidemiological investigation was therefore conducted as a case-control study to compare the seroprevalences of BHV-4 infections in the aborted-cow population and in a randomly selected control group in the province of Liege (Belgium). The seroprevalence (17.2%) in aborted cows was significantly higher than that of the control group (10.0%). The odds ratio (OR) was 1.87 (1.06 < 3.30). BHV-4 infection is therefore considered as a risk factor for abortion in cows. [less ▲]

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See detailCompte rendu de A. Debru, Le corps respirant: la pensée physiologique chez Galien, Leiden, 1996 (Studies in Ancient Medicine, 13)
Marganne, Marie-Hélène ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1998), 67

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See detailConstruction de tarifs de cubage d'arbres pour l’aulne glutineux (Alnus glutinosa (L.) Gaertn.).
Thibaut, André; Rondeux, Jacques ULg; Claessens, Hugues ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(3), 203-213

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See detailBelgium : a planning environment both rigid and flexible
Merenne-Schoumaker, Bernadette ULg

in European Retail Digest (1998), (20), 29-30

Short notice on commercial planning in Belgium in a comparative perspective with other European countries analyzed in the same publication

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See detailSevere congenital hypopituitarism with low prolactin levels and age-dependent anterior pituitary hypoplasia: a clue to a PIT-1 mutation
Ward, L.; Chavez, M.; Huot, C. et al

in Journal of Pediatrics (1998), 132(6), 1036-8

A 20-month-old boy presented with severe congenital growth hormone, thyrotropin, and prolactin deficiencies resulting from a de novo mutation of the PIT-1 gene. This form of congenital hypopituitarism ... [more ▼]

A 20-month-old boy presented with severe congenital growth hormone, thyrotropin, and prolactin deficiencies resulting from a de novo mutation of the PIT-1 gene. This form of congenital hypopituitarism should be suspected if pituitary anatomy is normal, especially if prolactin levels are low and, in boys, if the external genitalia are normal. Pituitary atrophy appears to be an age-dependent phenomenon in this condition. [less ▲]

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See detailThe DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
Bonjean, K.; De Pauw-Gillet, Marie-Claire ULg; Defresne, Marie-Paule ULg et al

in Biochemistry (1998), 37(15), 5136-46

Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of Cryptolepis sanguinolenta. It is characterized by a multiplicity of host-mediated biological activities, including ... [more ▼]

Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of Cryptolepis sanguinolenta. It is characterized by a multiplicity of host-mediated biological activities, including antibacterial, antiviral, and antimalarial properties. To date, the molecular basis for its diverse biological effects remains largely uncertain. Several lines of evidence strongly suggest that DNA might correspond to its principal cellular target. Consequently, we studied the strength and mode of binding to DNA of cryptolepine by means of absorption, fluorescence, circular, and linear dichroism, as well as by a relaxation assay using DNA topoisomerases. The results of various optical and gel electrophoresis techniques converge to reveal that the alkaloid binds tightly to DNA and behaves as a typical intercalating agent. In DNAase I footprinting experiments it was found that the drug interacts preferentially with GC-rich sequences and discriminates against homo-oligomeric runs of A and T. This study has also led to the discovery that cryptolepine is a potent topoisomerase II inhibitor and a promising antitumor agent. It stabilizes topoisomerase II-DNA covalent complexes and stimulates the cutting of DNA at a subset of preexisting topoisomerase II cleavage sites. Taking advantage of the fluorescence of the indoloquinoline chromophore, fluorescence microscopy was used to map cellular uptake of the drug. Cryptolepine easily crosses the cell membranes and accumulates selectively into the nuclei rather than in the cytoplasm of B16 melanoma cells. Quantitative analyses of DNA in cells after Feulgen reaction and image cytometry reveal that the drug blocks the cell cycle in G2/M phases. It is also shown that the alkaloid is more potent at inhibiting DNA synthesis rather than RNA and protein synthesis. Altogether, the results provide direct evidence that DNA is the primary target of cryptolepine and suggest that this alkaloid is a valid candidate for the development of tumor active compounds. [less ▲]

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See detailUse of a variable incidence angle PIXE arrangement for studying pigment multilayers
Weber, Georges ULg; Delbrouck, J. M.; Strivay, David ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (1998), 139(1-4), 196-201

Particle induced X-ray emission (PIXE) method is used in the field of archeometry and specially to investigate pigment colored multilayers. The tilting of the sample with respect to the incident proton ... [more ▼]

Particle induced X-ray emission (PIXE) method is used in the field of archeometry and specially to investigate pigment colored multilayers. The tilting of the sample with respect to the incident proton beam direction allows to modify the relative contribution of each layer to the fluorescence signal. The experimental results coupled to computer simulations lead to semi-quantitative information about the thickness, the position and the composition of the successive layers. (C) 1998 Elsevier Science B.V. [less ▲]

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See detailEnhanced expression in seminoma of human zinc finger genes located on chromosome 19
Ogawa, Takehiko; Poncelet, Dominique A; Kinoshita, Yuzo et al

in Cancer Genetics & Cytogenetics (1998), 100(1), 36-42

Six Kruppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Kruppel-associated box) ZF gene family and also the same ... [more ▼]

Six Kruppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Kruppel-associated box) ZF gene family and also the same chromosomal assignment. Interestingly, Northern blot analyses using ZFS-1 and ZNF91 revealed that multiple ZF genes on chromosome 19 were predominantly expressed in seminomas. In addition, the testis and the seminoma showed specific expression of 2.3 kb transcript. Our results suggest that ZF genes on chromosome 19 may be implicated in the development and/or growth of seminomas. [less ▲]

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See detailOsteochondrosis lesion of the lombo-sacral joint in a mastiff
Snaps, Frédéric ULg; Heimann, M.; Saunders, J. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(17), 476-477

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See detailInfluence of the A-->G (-3826) uncoupling protein-1 gene (UCP1) variant on the dynamics of body weight before and after gastroplasty in morbidly obese subjects.
Luyckx, Françoise ULg; Scheen, André ULg; Proenza, A. M. et al

in International Journal of Obesity & Related Metabolic Disorders (1998), 22(12), 1244-5

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See detailConservative Mutations In The Immunosuppressive Region Of The Bovine Leukemia Virus Transmembrane Protein Affect Fusion But Not Infectivity In Vivo
GATOT, Jean-Stéphane ULg; Callebaut, I.; Mornon, Jp. et al

in Journal of Biological Chemistry (1998), 273(21),

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See detailRandomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II)
Serruys, P. W.; van Hout, B.; Bonnier, H. et al

in Lancet (1998), 352(9129), 673-81

BACKGROUND: The multicentre, randomised Benestent-II study investigated a strategy of implantation of a heparin-coated Palmar-Schatz stent plus antiplatelet drugs compared with the use of balloon ... [more ▼]

BACKGROUND: The multicentre, randomised Benestent-II study investigated a strategy of implantation of a heparin-coated Palmar-Schatz stent plus antiplatelet drugs compared with the use of balloon angioplasty in selected patients with stable or stabilised unstable angina, with one or more de-novo lesions, less than 18 mm long, in vessels of diameter 3 mm or more. METHODS: 827 patients were randomly assigned stent implantation (414 patients) or standard balloon angioplasty (413 patients). The primary clinical endpoint was event-free survival at 6 months, including death, myocardial infarction, and the need for revascularisation. The secondary endpoints were the restenosis rate at 6 months and the cost-effectiveness at 12 months. There was also one-to-one subrandomisation to either clinical and angiographic follow-up or clinical follow-up alone. Analyses were by intention to treat. FINDINGS: Four patients (one stent group, three angioplasty group) were excluded from analysis since no lesion was found. At 6 months, a primary clinical endpoint had occurred in 53 (12.8%) of 413 patients in the stent group and 79 (19.3%) of 410 in the angioplasty group (p=0.013). This significant difference in clinical outcome was maintained at 12 months. In the subgroup assigned angiographic follow-up, the mean minimum lumen diameter was greater in the stent group than in the balloon-angioplasty group, (1.89 [SD 0.65] vs 1.66 [0.57] mm, p=0.0002), which corresponds to restenosis rates (diameter stenosis > or =50%) of 16% and 31% (p=0.0008). In the group assigned clinical follow-up alone, event-free survival rate at 12 months was higher in the stent group than the balloon-angioplasty group (0.89 vs 0.79, p=0.004) at a cost of an additional 2085 Dutch guilders (US$1020) per patient. INTERPRETATION: Over 12-month follow-up, a strategy of elective stenting with heparin-coated stents is more effective but also more costly than balloon angioplasty. [less ▲]

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See detailInsulin-like growth factor-I (IGF-I), IGF-binding proteins synthesis, and thyroid status are affected by dexamethasone esters treatment in finishing calves
Bertozzi, Carlo; Massart, Serge; Prandi, Alberto et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 45

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See detailChorologie et écologie de Pycnoporus Cinnabarinus (Polyporaceae) en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes
Thoen, Daniel ULg; Fraiture, A.; Nicolas, Jacques ULg

in Belgian Journal of Botany (1998), 131(2), 260-272

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de ... [more ▼]

L'extension récente, après 1960, de Pycnoporus cinnabarinus, en Belgique, au Grand-Duché de Luxembourg et dans les régions limitrophes est analysée à l'aide d'une série chronologique de cartes de distribution. La propagation du champignon semble s'être effectuée à deux "vitesses" : par bonds, sur des distances de plusieurs dizaines de kilomètres, et de proche en proche, au départ de populations voisines. L'analyse de la fréquence et de la fréquence cumulée des récoltes montre deux grandes "vagues" successives d'expansion du champignon. La liste des arbres hôtes est établie ainsi que la fréquence relative du champignon en fonction des hôtes. Les hôtes les plus fréquents sont les bouleaux (Betula alba et Betula pendula), le hêtre (Fagus sylvatica), le sorbier des oiseleurs (Sorbus aucuparia) et les chênes (Quercus robur et Quercus petraea). Les causes de l'extension et des fluctuations des populations du champignon ne sont pas connues avec certitude. Il semble cependant que des facteurs climatiques et le fait que de plus grandes quantités de bois pourrissant soient abandonnées sur les coupes puissent être impliqués. [less ▲]

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See detailL'hyperventilation chronique existe-t-elle?
Delvaux, Muriel ULg; Fontaine, Philippe; Fontaine, Ovide ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (1998), 3(3), 1-9

Longtemps, on a considéré que les sujets atteints d’attaques de panique étaient des hyperventilants chroniques qui plongeaient soudainement en hypocapnie. En fait, l’examen des résultats au test de ... [more ▼]

Longtemps, on a considéré que les sujets atteints d’attaques de panique étaient des hyperventilants chroniques qui plongeaient soudainement en hypocapnie. En fait, l’examen des résultats au test de provocation d’hyperventilation, de la rééducation respiratoire et de la mesure ambulatoire de PCO2 montre qu’il n’y a pas de recouvrement parfait entre les deux phénomènes. Le syndrome d’hyperventilation est sans doute une entité à part entière. Les modèles biologiques se basent sur les expériences utilisant le lactate ou le dioxyde de carbone pour aboutir, avec Klein (1993), à l’hypothèse d’une hypersensibilité au CO2. Les modèles psychologiques envisagent diverses options. Lum (1994) y voit la conséquence d’une mauvaise habitude respiratoire. Pour Clark (1986), l’hyperventilation joue un rôle dans les attaques de panique seulement si elle est interprétée de manière catastrophique. Ley (1993) considère la dyspnée comme l’élément initiateur d’un réflexe de peur innée. Enfin, Van den Bergh (1995) a réalisé des études prometteuses sur le conditionnement respiratoire. Si tous les sujets souffrant d’attaques de panique ne sont pas des hyperventilants chroniques, il faut admettre que les deux phénomènes coexistent souvent. Une approche intégrative des modèles biologiques et psychologiques pourrait éclaircir la nature de leur relation. [less ▲]

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See detailQuestions de droit pénal du travail
Kefer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (1998)

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See detailFormation of the 67-kDa laminin receptor by acylation of the precursor.
Buto, S.; Tagliabue, E.; Ardini, E. et al

in Journal of Cellular Biochemistry (1998), 69(3), 244-51

Even though the involvement of the 67-kDa laminin receptor (67LR) in tumor invasiveness has been clearly demonstrated, its molecular structure remains an open problem, since only a full-length gene ... [more ▼]

Even though the involvement of the 67-kDa laminin receptor (67LR) in tumor invasiveness has been clearly demonstrated, its molecular structure remains an open problem, since only a full-length gene encoding a 37-kDa precursor protein (37LRP) has been isolated so far. A pool of recently obtained monoclonal antibodies directed against the recombinant 37LRP molecule was used to investigate the processing that leads to the formation of the 67-kDa molecule. In soluble extracts of A431 human carcinoma cells, these reagents recognize the precursor molecule as well as the mature 67LR and a 120-kDa molecule. The recovery of these proteins was found to be strikingly dependent upon the cell solubilization conditions: the 67LR is soluble in NP-40-lysis buffer whereas the 37LRP is NP-40-insoluble. Inhibition of 67LR formation by cerulenin indicates that acylation is involved in the processing of the receptor. It is likely a palmitoylation process, as indicated by sensitivity of NP-40-soluble extracts to hydroxylamine treatment. Immunoblotting assays performed with a polyclonal serum directed against galectin3 showed that both the 67- and the 120-kDa proteins carry galectin3 epitopes whereas the 37LRP does not. These data suggest that the 67LR is a heterodimer stabilized by strong intramolecular hydrophobic interactions, carried by fatty acids bound to the 37LRP and to a galectin3 cross-reacting molecule. [less ▲]

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See detailIn vitro modulation of human gingival epithelial cell attachment and migration by minocycline-HCL.
Van Heusden, Alain ULg; Nusgens, Betty ULg; Goffinet, Gerhard ULg et al

in Journal of Periodontal Research (1998), 33(6), 377-85

Although the influence of tetracyclines on periodontal connective tissue cells has been the topic of many in vitro and in vivo studies, data regarding their effects on gingival epithelial cells are scarce ... [more ▼]

Although the influence of tetracyclines on periodontal connective tissue cells has been the topic of many in vitro and in vivo studies, data regarding their effects on gingival epithelial cells are scarce. The present in vitro study was designed to examine the influence of minocycline, a semi-synthetic analog of tetracycline, on human gingival keratinocyte (HGK) attachment and migration. Attachment tests were performed with HGK prelabeled by tritiated amino-acids. Increasing concentrations of minocycline (10, 50, 100 micrograms/ml) in the medium produced no significant modification of cell adhesion kinetics compared to control conditions, except for 100 micrograms/ml which statistically significantly (p < 0.05) reduced the number of attached cells beyond 6 h. A 24-h cell preincubation in 10 micrograms/ml of minocycline did not alter the kinetics of HGK attachment. Scanning electron microscopic observations of attached HGK showed that the presence of 10 micrograms/ml of minocycline in the "attachment medium" induced the production of multiple filopodial extensions. Migration tests in Boyden chambers for 40 h demonstrated that HGK preincubation for 24 h in a 10 micrograms/ml minocycline-HCl solution increased significantly (p < 0.005) cell migration towards a gradient of fetal calf serum. The presence of 10 micrograms/ml of minocycline in contact with the keratinocytes in the upper compartment of the migration chambers also produced a significant (p < 0.005) result. In contrast, the presence of minocycline in the lower compartments did not produce any chemoattractive effect. Within the limits of their significance, these results suggest that, at concentrations not beyond 50 micrograms/ml, minocycline could fasten the periodontal wound coverage by epithelial cells and allow the normal reformation of a junctional epithelium. [less ▲]

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See detailPremière mise en évidence en Belgique de particules ressemblant à des circovirus.
Duchatel, Jean-Pierre ULg; Jauniaux, Thierry ULg; Vandersanden F et al

in Annales de Médecine Vétérinaire (1998), 142

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See detailVariations in systemic and pulmonary endothelin-1 in horses with recurrent airway obstruction (heaves)
Benamou, A. E.; Art, Tatiana ULg; Marlin, D. J. et al

in Pulmonary Pharmacology & Therapeutics (1998), 11

Recurrent airway obstruction (RAO) is an asthma-like condition of the horse that represents a major cause of morbidity and loss of performance. The exact pathogenesis of asthma in man is unclear but the ... [more ▼]

Recurrent airway obstruction (RAO) is an asthma-like condition of the horse that represents a major cause of morbidity and loss of performance. The exact pathogenesis of asthma in man is unclear but the role of endothelin (ET) is currently under investigation, thus sparking interest in the bronchoconstrictive and vasoconstrictive properties of endothelin in the equine-specific disease entity. In this study, we investigated the levels of ET-1 in systemic blood, as well as in bronchoalveolar lavage (BAL) from horses with RAO. We also studied how these values might correlate with those of lung function tests and pulmonary artery pressure. Five horses with RAO were evaluated both in remission and in crisis and compared to five control horses. RAO horses had significantly (P<0.05) higher systemic ET-1 levels than control horses. They also had a negative arteriovenous ET-1 difference that may correspond to a net uptake of ET-1 in the lung. RAO horses in crisis had increased amounts of immunoreactive ET in BAL fluid compared to normal control subjects. Additionally, the reduction in lung function seen in RAO horses in crisis was significantly correlated with lower epithelial lining fluid ET-1 levels. Our results demonstrate that endothelin may contribute to the pathogenesis of asthma. [less ▲]

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See detailRelevant radiological anatomy of the pig as a training model in interventional radiology
Dondelinger, R. F.; Ghysels, M. P.; Brisbois, D. et al

in European Journal of Radiology (1998), 8

The use of swine for teaching purposes in medicine and surgery has largely increased in recent years. Detailed knowledge of the porcine anatomy and physiology is a prerequisite for proper use of pigs as a ... [more ▼]

The use of swine for teaching purposes in medicine and surgery has largely increased in recent years. Detailed knowledge of the porcine anatomy and physiology is a prerequisite for proper use of pigs as a teaching or an experimental model in interventional radiology. A systematic study of the radiological anatomy was undertaken in more than 100 female pigs aged 6-8 weeks. All studies were performed under general anesthesia in a single session. Animals were sacrificed at the end of the study. Selective angiographies were systematically obtained in all anatomical territories. In other animals CT and MRI examinations were performed and were correlated to anatomical sections and acrylic casts of the vascular structures. Endoscopical examinations of the upper gastrointestinal tract, including retrograde opacification of the biliary and pancreatic ducts, were added in selected animals. The main angiographic aspects of the brain, head and neck, thorax, abdomen, and pelvis were recorded. Similarities and differences in comparison with human anatomy are stressed. Potential applications in interventional radiology are indicated. [less ▲]

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See detailGrowth hormone binding protein (GHBP) during lactation in cows
Renaville, Robert ULg; Prandi, Alberto; Massart, Serge et al

in Archivio Veterinario Italiano (1998), 48

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See detailQuelle place pour l'isocinétisme dans la rééducation de l'épaule?
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg

in Lettre de Médecine Physique et de Réadaptation (1998), 48

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See detailAnemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production.
Corazza, Francis; Beguin, Yves ULg; Bergmann, Pierre et al

in Blood (1998), 92(5), 1793-8

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect ... [more ▼]

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). To further elucidate the pathophysiology of anemia in children with cancer, we measured serum soluble transferrin receptor (sTfR), a quantitative marker of erythropoiesis, and serum EPO at time of diagnosis and during chemotherapy in children suffering from solid tumor or leukemia. We determined serum EPO in 111 children (55 leukemia, 56 solid tumors) at time of diagnosis. In the last 44 patients (23 leukemia and 21 solid tumors), sTfR levels were also measured. Serum EPO together with sTfR levels were also determined in 60 children receiving chemotherapy (29 leukemia, 31 solid tumors). These results were compared with those obtained from appropriate control groups. In all patients, we found a highly significant correlation between the logarithm of EPO (log[EPO]) and the hemoglobin (Hb) level. In all subsets of patients, sTfR levels were inappropriately low for the degree of anemia. Neither leukemic nor solid tumor groups showed a significant inverse relationship between log(sTfR) and the Hb level as would be expected in anemic patients with appropriate marrow response. Thus, in children with cancer, anemia is associated with a decreased total bone marrow erythropoietic activity which, in contrast to what has been reported in anemic cancer adults, is not related to defective EPO production. [less ▲]

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See detailRandomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study.
Bertrand, M. E.; Legrand, Victor ULg; Boland, J. et al

in Circulation (1998), 98(16), 1597-603

BACKGROUND: Dual therapy with ticlopidine and aspirin has been shown to be as effective as or more effective than conventional anticoagulation in patients with an optimal result after implantation of ... [more ▼]

BACKGROUND: Dual therapy with ticlopidine and aspirin has been shown to be as effective as or more effective than conventional anticoagulation in patients with an optimal result after implantation of intracoronary metallic stents. However, the safety and efficacy of antiplatelet therapy alone in an unselected population has not been evaluated. METHODS: Patients were randomized to conventional anticoagulation or to treatment with antiplatelet therapy alone. Indications for stenting were classified as elective (decided before the procedure) or unplanned (to salvage failed angioplasty or to optimize the results of balloon angioplasty). After stenting, patients received aspirin and either ticlopidine or conventional anticoagulation (heparin or oral anticoagulant). The primary end point was the occurrence of bleeding or peripheral vascular complications; secondary end points were cardiac events (death, infarction, or stent occlusion) and duration of hospitalization. RESULTS: In 13 centers, 236 patients were randomized to anticoagulation and 249 to antiplatelet therapy. Stenting was elective in 58% of patients and unplanned in 42%. Stent implantation was successfully achieved in 99% of patients. A primary end point occurred in 33 patients (13.5%) in the antiplatelet group and 48 patients (21%) in the anticoagulation group (odds ratio=0.6 [95% CI 0.36 to 0.98], P=0.03). Major cardiac-related events in electively stented patients were less common (odds ratio=0.23 [95% CI 0.05 to 0.91], P=0.01) in the antiplatelet group (3 of 123, 2.4%) than the anticoagulation group (11 of 111, 9.9%). Hospital stay was significantly shorter in the antiplatelet group (4.3+/-3.6 versus 6. 4+/-3.7 days, P=0.0001). CONCLUSIONS: Antiplatelet therapy after coronary stenting significantly reduced rates of bleeding and subacute stent occlusion compared with conventional anticoagulation. [less ▲]

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See detailScale relativity and quantization of the solar system - Orbit quantization of the planet's satellites
Hermann, Raphaël ULg; Schumacher, G.; Guyard, R.

in Astronomy and Astrophysics (1998), 335(1), 281-286

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present ... [more ▼]

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present paper we show that one more class of objects of the solar system satisfy the rule of quantization, this class including the main satellites and rings of the outer planets. We also give a classification of the satellites by rank, showing that one can predict the existence of certain orbits that are not occupied, or whose objects are not yet discovered. [less ▲]

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See detailThe Division and Cell Wall Gene Cluster of Enterococcus Hirae S185
Duez, Colette ULg; Thamm, Iris ULg; Sapunaric, Frédéric ULg et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1998), 9(3), 149-161

A chromosomal 10355-bp segment of Enterococcus hirae S185 contains nine orfs which occur in the same order as the MraW-, FtsL-, PBP3-, MraY-, MurD-, MurG-, FtsQ-, FtsA- and FtsZ-encoding genes of the ... [more ▼]

A chromosomal 10355-bp segment of Enterococcus hirae S185 contains nine orfs which occur in the same order as the MraW-, FtsL-, PBP3-, MraY-, MurD-, MurG-, FtsQ-, FtsA- and FtsZ-encoding genes of the division and cell wall clusters of Escherichia coli and Bacillus subtilis. The E. hirae DNA segment lacks the genes which in E. coli encode the ligases Ddl, MurC, MurE and MurF and the integral membrane protein FtsW. The encoded E. hirae and E. coli proteins share 25% to 50% identity except FtsL and FtsQ (approximately = 14% identity). [less ▲]

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See detailTrimalchion ou l'antijudaïsme de Pétrone
Rochette, Bruno ULg

in Revues des études juives (1998), 44

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See detailHigh presure: a unique tool for pressurisation
Dumoulin, Mireille ULg; Hayashi, Rikimaru

in Food Science & Technology International (1998), 4

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See detailStereoselective determination of S-naproxen in tablets by capillary electrophoresis.
Fillet, Marianne ULg; Fotsing, Lucas; Bonnard, J. et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 18(4-5), 799-805

A capillary electrophoresis (CE) method was developed for the stereoselective determination of the non-steroidal anti-inflammatory drug (NSAID), S-naproxen, in tablets. Several beta-cyclodextrin ... [more ▼]

A capillary electrophoresis (CE) method was developed for the stereoselective determination of the non-steroidal anti-inflammatory drug (NSAID), S-naproxen, in tablets. Several beta-cyclodextrin derivatives (CDs) were tested as chiral selectors, including sulfobutyl-beta-CD (SBCD), carboxymethyl-beta-CD (CMCD), dimethyl-beta-CD (DMCD) and trimethyl-beta-CD (TMCD), in a phosphoric acid/triethanolamine pH 3 buffer. Under these conditions, the analyte was mainly present in an uncharged form and therefore, the use a neutral CD (DMCD or TMCD) alone could not lead to enantiomeric separation. On the contrary, by addition of a charged CD (SBCD or CMCD) to the running buffer, giving the analyte enantiomers an adequate mobility, chiral resolution could be achieved, although the resolution values obtained in this case were not quite satisfactory (Rs < 1.5). Dual systems, based on the use of mixtures of charged and neutral CDs, were then investigated. The SBCD/TMCD system was found to be particularly well suited to the enantioseparation of naproxen and after optimisation of the concentrations of both CDs, a resolution value of 5.4 could be obtained. The method was validated for the determination of R-naproxen (enantiomeric impurity) in the 0.1-2% range, using the racemic mixture of the analyte. A second validation was performed in the 50-150% range for the quantitation of S-naproxen. In both cases, good results with respect to linearity, precision and accuracy were obtained. [less ▲]

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See detailL'image du mois. Quelle chute!
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(12), 725-6

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See detailPharmaco-economie du diabete de type 2.
Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (1998), 53(5), 285-9

Type 2 diabetes has long been considered as a benign disease, whereas it is in fact associated with an enormous socio-economic cost. The major part of the burden of diabetes results from the management of ... [more ▼]

Type 2 diabetes has long been considered as a benign disease, whereas it is in fact associated with an enormous socio-economic cost. The major part of the burden of diabetes results from the management of complications (both direct and indirect costs), rather than from the various components of the antihyperglycaemic treatment itself. Solutions include a better prevention of the disease, an earlier diagnosis among individuals at risk, and an optimized management of diabetes, particularly in primary care settings, in order to avoid or retard the development of severe micro- or macroangiopathic complications which are particularly expensive. [less ▲]

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See detailRadial tree-growth modelling with fuzzy regression.
Boreux, Jean-Jacques ULg; Gadbin-Henry, C.; Guiot, Joël et al

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (1998), 28(8), 1249-1260

A so-called fuzzy linear regression is used in dendroecology to model empirically tree growth as a function of a bioclimatic index representing the water stress, i.e., the ratio of actual ... [more ▼]

A so-called fuzzy linear regression is used in dendroecology to model empirically tree growth as a function of a bioclimatic index representing the water stress, i.e., the ratio of actual evapotranspiration to potential evapotranspiration. The response function predicts tree growth as (fuzzy) intervals, narrow in the domain where the bioclimatic index is most limiting and becoming progressively larger elsewhere. The method is tested with a population of Pinus pineaL. from the Provence region in France. It is shown that fuzzy linear regression gives results comparable with those obtained using a linear response function. The interval of credibility given by the fuzzy regression suggests that more precise expected growth is obtained for high water stress, which is typical of Mediterranean climate. Fuzzy linear regression can be also a method to test different hypotheses on several potential predictors when any further experimental approach is quite impossible as it is for trees in their natural environment. To sum up, fuzzy regression could be a first step before the construction of a kind of growth simulator adapted to different environments of a given species. In environmental sciences, the fuzzy response function thus appears to be an approach between the mechanistic and the statistical descriptive approaches. [less ▲]

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See detailL'embolisation scrotale antegrade de la varicocele--resultats.
Frangi, I.; Keppenne, Véronique ULg; Coppens, Luc ULg et al

in Acta Urologica Belgica (1998), 66(4), 5-8

The aim of this study is to judge the effectiveness of the new treatment of varicoceles, introduced in 1987 by Tauber: the antegradal scrotal sclerotherapy of varicoceles. From february 1996 to april 1998 ... [more ▼]

The aim of this study is to judge the effectiveness of the new treatment of varicoceles, introduced in 1987 by Tauber: the antegradal scrotal sclerotherapy of varicoceles. From february 1996 to april 1998, we have realised 150 antegrade embolisations of varicoceles. The study is lead on 75 patients with mean time follow-up of 12 months. Patient's mean age is 20 years. 85% of patients had a grade 3 left varicocele and 15% a grade 2 left varicocele. The criterium of success rests on the lack of veinous flow-back during clinical examination, which is than confirmed by doppler-ultrasound. Clinical success is obtained in 87% of the cases and the doppler control is normal in 80% of the cases. We have 9% of minor complications, and no major complication. The number of failures in our study is higher than in Tauber' study, but is the same as those described in the other procedures of treatment of varicocele. On the other hand the surgical procedure is simple and the morbidity is low. [less ▲]

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See detailAutonomy to plant growth regulators and gene expression in periwinkle cultures in vitro
Droual, Anne-Marie; Hamdi, Said; Creche, Joel et al

in Journal of Plant Physiology (1998), 153(5-6), 623-630

To better understand the effect of habituation on gene expression in plant cells, we have compared the accumulation of specific mRNAs encoding respectively two proline-rich proteins, a chaperone protein ... [more ▼]

To better understand the effect of habituation on gene expression in plant cells, we have compared the accumulation of specific mRNAs encoding respectively two proline-rich proteins, a chaperone protein and three enzymes linking primary and secondary metabolisms in two models of in vitro culture of periwinkle. These models consisted of two couples of a 2,4-dichlorophenoxyacetic acid-dependent/2,4-dichlorophenoxyacetic acid independent line in which autonomy to auxin and cytokinin was obtained either through habituation or through transformation with the isopentenyltransferase gene from Agrobacterium tumefaciens. Results showed that gene expression was modified by plant growth regulator autonomy but differently according to the type of autonomy: only the gene encoding a hydroxyproline-rich glycoprotein was regulated similarly in both PGR-independent lines. On the other hand, PGR autonomy did not lead to total insensitivity to exogenously-applied PGRs, and the two PGR autonomous lines did not accumulate indole alkaloids for different reasons. [less ▲]

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See detailLes thérapeutiques à visée spécifiquement osseuse dans le traitement de l'ostéoporose postménopausique. Aspects pharmaco-économiques
Reginster, Jean-Yves ULg; Ben Sedrine, Wafa ULg; Gosset, Christiane ULg

in Revue Médicale de Liège (1998), 53(5), 290-293

Fairly new economic evaluations were, so far, properly conducted in the field of prevention and treatment of osteoporosis. This lack of studies is likely to be related to the pathophysiology and the ... [more ▼]

Fairly new economic evaluations were, so far, properly conducted in the field of prevention and treatment of osteoporosis. This lack of studies is likely to be related to the pathophysiology and the natural course of the disease, the small number of disease-specific instruments allowing the evaluation of quality of life changes following fractures and the frequent interaction of osteoporotic treatments with other body systems. Notwithstanding a lot of efforts have to be brought before economic evaluations in osteoporosis become a key determinant of Public Health strategies, it remains of prime interest to promote this type of research taking into account the importance of the social, human and economic burden of this disease. [less ▲]

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See detailLe prologue du livre de Ben Sirach le Sage et la traduction des textes sacrés
Rochette, Bruno ULg

in Babel : Revue Internationale de la Traduction = International Journal of Translation (1998), 44(2), 139-149

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See detailPd-Ag/SiO2 sol-gel catalysts designed for selective conversion of chlorinated alkanes into alkenes
Heinrichs, Benoît ULg; Delhez, Patrice; Schoebrechts, Jean-Paul et al

in Studies in Surface Science and Catalysis (1998), 118

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See detailAdolescence...Quand tu nous tiens
Stassart, Martine ULg

in Mélanges Cliniques (1998)

In view of studying the psychodynamic assessment of the vocational attitude of the 18 years old adolescent, according to his self-representation as resolute, undecided, or quite determined, we ... [more ▼]

In view of studying the psychodynamic assessment of the vocational attitude of the 18 years old adolescent, according to his self-representation as resolute, undecided, or quite determined, we investigated the psychical process of a sample of 30 subjects through a set of cognitive tests (F.I.D., Locus of Control) and projective tests (TAT, Rorschach, Szondi) with regard to cognitive perceptive aspects and identification patterns. The sample was consisting of 30 final year students subdivided into three categories, namely resolute, undecided, quite-determined, each group including five females and five males. The 30 subjects were again contacted four years latter and retested (except one). At first, we interpreted, case by case, for each group, the cognitive tests, the T.A.T., the Rorschach, and the Szondi in order. In a second time, we performed a statistical analysis of all quantifiable data. In the frame of this presentation, we will focus on findings of projective techniques. In the light of the projective tests, the characters "resolute", "undecided", and "quite-determined", taken as symptoms, seem to be supported by specific intra-psychical dynamics. So far it must be pointed out that females intrapsychical dynamic is always better than male's one. [less ▲]

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See detailHemovigilance: Clinical Tolerance of Solvent-Detergent Treated Plasma
Baudoux, Etienne ULg; Margraff, U.; Coenen, Alain ULg et al

in Vox Sanguinis (1998), 74(Suppl 1), 237-9

OBJECTIVE: This study was conducted to assess retrospectively the clinical tolerance of SD treated plasma and to compare it to other labile blood products (red blood cell and platelet concentrates ... [more ▼]

OBJECTIVE: This study was conducted to assess retrospectively the clinical tolerance of SD treated plasma and to compare it to other labile blood products (red blood cell and platelet concentrates). METHODS: Adverse events (AEs) related to the use of blood products at the Blood Transfusion Center (BTC) are routinely collected through a formalised system of hemovigilance. All AEs reported are entered into a safety data base which was used for the study. All AEs reported during a one-year period to the BTC were retrospectively re-assessed and descriptive statistics calculated. RESULTS: 5064 units of SD treated plasma were transfused to 894 recipients during the study period at the occasion of 1553 transfusions. No AE associated to SD treatment plasma was reported during that period. In contrast, during the same period, 485 AEs associated with the use of red blood cell concentrates (RBCC) were reported in 251 patients at the occasion of 262 transfusions. 2.1% (251/11,748) of the patients transfused with RBCC experienced one or more AEs. The incidence of AEs per unit transfused was 1.3% (485/37,332), and 2.4% (485/20,460) of RBCC transfusions were associated with one or more AEs. 142 AEs associated with the use of platelet concentrate (PC) were observed in 69 patients at the occasion of 73 transfusions. 4.2% (69/1645) of patients transfused with PC experienced one or more AEs. The incidence of AEs per unit transfused was 1.1% (142/12,772), and 2.8% (142/5034) of PC transfusions were associated with one or more AEs. All reported AEs were classified and non serious. The most frequently observed AEs were fever, chills and rashes which accounted for roughly 64% of all reported AEs. CONCLUSION: As for the overall clinical tolerance of red cell and platelet concentrates, the results of this study are in complete agreement with the published literature. The study also confirms the extremely good tolerability of SD treated plasma in comparison with other labile blood products. [less ▲]

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See detailDelayed-onset profound biotinidase deficiency.
Wolf, B.; Pomponio, R. J.; Norrgard, K. J. et al

in The Journal of pediatrics (1998), 132(2), 362-5

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb ... [more ▼]

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb weakness, spastic paresis, and eye problems, such as loss of visual acuity and scotomata, rather than the more characteristic symptoms observed in young untreated children with the disorder. These older children each have different mutations, but they are the same as those of children who have exhibited symptoms at an early age. Biotinidase deficiency should be considered in older children who suddenly experience limb weakness and/or spastic paresis and eye symptoms. [less ▲]

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See detailClinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure.
Eisele, Bernd; Lamy, Maurice ULg

in Seminars in Thrombosis & Hemostasis (1998), 24(1), 71-80

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years ... [more ▼]

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years and still comes to 35% to 45%. For quite a long time our understanding of the pathophysiology of sepsis was mainly focused on endotoxin and proinflammatory cytokines like tumor necrosis factor or interleukin-1. Now it is generally accepted that many signs and symptoms of sepsis are not directly mediated by cytokines but are transmitted through other mediator systems. The coagulation system comes into play especially when the septic process progresses to malperfusion and organ failure. Antithrombin III is an important inhibitor of the intrinsic, extrinsic and common pathway of coagulation. Recently, evidence has been accumulating that there is an additional anti-inflammatory potential of the drug. Currently there are several clinical trials ongoing to investigate whether this effect is of clinical relevance in the treatment of patients with severe sepsis. [less ▲]

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See detailJean le Lydien, Caton, Varron et Servius
Rochette, Bruno ULg

in Byzantinische Zeitschrift (1998), 91(2), 471-474

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See detailNew acylnitroso compounds for the asymetric oxyamination of dienes
Gouverneur, Véronique; Mc Carthy, S. J.; Mineur, C. et al

in Tetrahedron (1998), 54(35), 10537-10554

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See detailEvaluation of the effect of two training regimes on the resumption of the ovarian activity by analysis of faecal 20 alpha-hydroxyprogesterone in trotter mares
Messina, Mariella; Prandi, Alberto; Bolelli, G. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2

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See detailEffect of ice-nucleating bacteria (Pseudomonas syringae Van Hall) on insect susceptibility to sub-zero temperatures
Mignon, Jacques ULg; Haubruge, Eric ULg; Gaspar, Charles ULg

in Journal of Stored Products Research (1998), 34(1), 81-86

Many stored product insect pests are termed "freeze-intolerant" because they cannot survive ice formation in their extracellular body fluid. In grain silos, the progressive decrease in temperature permits ... [more ▼]

Many stored product insect pests are termed "freeze-intolerant" because they cannot survive ice formation in their extracellular body fluid. In grain silos, the progressive decrease in temperature permits the acclimation of insects and enhances their cold tolerance. The objective of this study was to examine the influence of the concentration of the ice-nucleating-active bacterium Pseudomonas syringae (10, 100 and 1000 ppm), temperature and duration of sub-zero exposure on the cold tolerance of the granary weevil Sitophilus granarius (L.) and the saw-toothed grain beetle Oryzaephilus surinamensis (L.). After an application of 1000 ppm of powdered P. syringae to grain, the mortality of S. granarius and O. surinamensis was increased after 24-h exposure to -4 degrees C. Higher mortality was observed after exposure to colder temperatures and a dose-response relationship was evident. At near-zero (-4 to 0 degrees C) negative temperatures, no dose response was observed, and the mortality in treated grain was the same as that in untreated grain. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailGrazing incidence X-ray reflectometry studies of CdTe(1 1 1) surfaces and a-Si thin films
Ijdiyaou, I.; Hafidi, K.; Azizan, M. et al

in Solar Energy Materials & Solar Cells (1998), 52

Chemically treated cadmium telluride (CdTe) surfaces and amorphous silicon (a-Si) thin films were characterized by X-ray reflectometry at grazing incidence. In the case of the surface of CdTe single ... [more ▼]

Chemically treated cadmium telluride (CdTe) surfaces and amorphous silicon (a-Si) thin films were characterized by X-ray reflectometry at grazing incidence. In the case of the surface of CdTe single crystal treated with an oxidizing agent (a solution of Br2 in CH3OH), the superficial layer was found to be less dense than its support with a profound alteration of CdTe in the volume. After rinsing in KOH solution, the properties of single-crystalline CdTe are obtained. In the case of a-Si thin layers, we show that the simulation of the reflectometry curves enables not only the determination of the layer thickness but also the detection of an ultrathin superficial oxide layer. [less ▲]

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See detailLe traitement des troubles chroniques des petites voies respiratoires
Van Erck, Emmanuelle; Duvivier, D.; Art, Tatiana ULg et al

in Pratique Vétérinaire Equine (1998), 30

Prevention and treatment of chronic respiratory diseases require improvement of the horse's environment (elimination of dust and allergen sources), adaptation of training conditions and early medical ... [more ▼]

Prevention and treatment of chronic respiratory diseases require improvement of the horse's environment (elimination of dust and allergen sources), adaptation of training conditions and early medical action against airway disfunctions. Therapeutic management rests on the control of inlammation and correction of functinnal disorders. Amongst all available drugs, corticosteroids are the most valued for theri anti-inflammatory actions, as well as their potentializing effect on bronchodilatators. Treatment can be delivered either systematically, in case of severe disease, or locally, by aerosoltherapy. This former technique allows delivery of precise doses and limits side effects. [less ▲]

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See detailThe Pathophysiology of Migraine: A Review Based on the Literature and on Personal Contributions
Schoenen, Jean ULg

in Functional Neurology (1998), 13(1, Jan-Mar), 7-15

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See detailLes thiazolidinediones : quel avenir dans le traitement du diabète de type 2 ?
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (1998), 56

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See detailCellular and molecular aspects of thymic T-cell education to neuroendocrine self principles: implications in autoimmunity
Geenen, Vincent ULg; Martens, Henri ULg; Kecha, Ouafae et al

in Annals of the New York Academy of Sciences (1998), 840

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See detailMolecular Definition of an Allelic Series of Mutations Disrupting the Myostatin Function and Causing Double-Muscling in Cattle
Grobet, Luc ULg; Poncelet, D.; Royo, L. J. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1998), 9(3), 210-3

We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be ... [more ▼]

We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous or compound heterozygotes for one of the five loss-of-function mutations. The absence of obvious loss-of-function mutations in the coding sequence of the two remaining breeds points either towards additional mutations in unexplored segments of the gene, or towards locus heterogeneity of double-muscling. [less ▲]

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See detailPulmonary function and pain after gastroplasty performed via laparotomy or laparoscopy in morbidly obese patients.
Joris, Jean ULg; Hinque, V. L.; Laurent, P. E. et al

in British Journal of Anaesthesia (1998), 80(3), 283-8

We have compared severely obese patients (body mass index > 35 kg m-2) undergoing laparoscopic or open gastroplasty (n = 15 in each group) to determine if laparoscopy results in any benefit in the obese ... [more ▼]

We have compared severely obese patients (body mass index > 35 kg m-2) undergoing laparoscopic or open gastroplasty (n = 15 in each group) to determine if laparoscopy results in any benefit in the obese. Postoperative pain, measured on a 100-mm visual analogue scale, and opioid consumption were recorded during the first two days after operation. Tests of pulmonary function were performed and SpO2 was measured 4 h after surgery and on days 1, 2 and 3 after operation. Pain at rest was similar in the two groups, but in the laparoscopy group, requirements for postoperative opioid were 50% less (P < 0.05). Pain intensity during mobilization and on coughing was significantly less after laparoscopy (differences between mean pain scores in both groups ranged from 20 to 32 mm during mobilization and from 32 to 34 mm during coughing). Forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow rate were reduced significantly less after laparoscopic gastroplasty than after open gastroplasty (on day 1 forced vital capacity was reduced by 50% compared with 64%, forced expiratory volume in 1 s was reduced by 50% compared with 66% and peak expiratory flow rate by 45% compared with 60%). SpO2 values were significantly greater in the laparoscopy group (day 1: mean 95 (SD 2)% vs 91 (5)%; day 3: 97 (1)% vs 94 (3)%). This study suggests that the beneficial effects observed after laparoscopic gastroplasty in morbidly obese patients were similar to those reported after laparoscopic cholecystectomy in non-obese patients. [less ▲]

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See detailLes minéraux secondaires en relation avec les sulfures de la région de Vielsalm, Belgique
Hatert, Frédéric ULg; Blondieau, Michel; Dehove, José et al

in Bulletin de la Société Royale des Sciences de Liège (1998), 67

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See detail"L'application dans le temps de l'article 1288, dernier alinéa, du code judiciaire", obs. sous J.P. Etalle, 24 décembre 1997 et 13 février 1998
Moreau, Pierre ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998), (17), 746

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See detailActualites therapeutiques 1997-1998 (1). Seconde partie.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(9), 518-23

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be stressed. This second part is devoted to drugs acting on infectious, rheumatoid, immunologic, oncologic and urogenital diseases. [less ▲]

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See detailGrandir en l'an 2000 : les enfants et l'école maternelle
Crahay, Marcel ULg; Hindryckx, Geneviève ULg; Lafontaine, Annette ULg et al

in Point sur la Recherche en Education (Le) (1998), 6

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See detailPharma-clinics. Le medicament du mois. Le formoterol (Oxis Turbohaler).
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(11), 715-8

Formoterol, commercialized by Astra under the trade name Oxis, is a new potent and selective agonist of beta-2 adrenergic receptors, which is used with a specific device (Turbohaler) allowing effective ... [more ▼]

Formoterol, commercialized by Astra under the trade name Oxis, is a new potent and selective agonist of beta-2 adrenergic receptors, which is used with a specific device (Turbohaler) allowing effective inhalation. Bronchodilatation occurs rapidly, within 1-3 minutes after inhalation, and lasts about 12 hours after the administration of a unique dose. Oxis Turbohaler is indicated to reduce symptoms associated with bronchial obstruction in asthmatic patients when the control of asthma is not achieved with inhaled corticoid therapy. It is not indicated for the treatment of acute crisis. It is presented as powder vials for inhalation (4.5 or 9 micrograms per dose). The usual dose in adults is 1-2 inhalations 1-2 times per day, in the morning and/or in the evening (bedtime administration should be recommended in case of nocturnal asthma). There is not enough data for treating children. The lowest dose allowing adequate control of asthma should be selected for chronic treatment. [less ▲]

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See detailUn revenant au Faubourg Saint-Léonard à Liège en 1634
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (1998), t.XIII, n° 283

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See detailLes mycoplasmes respiratoires des bovins : I. Clinique, diagnostic et traitement
Linden, Annick ULg; Thomas, A.; Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (1998), 142

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See detailA Qtl with Major Effect on Milk Yield and Composition Maps to Bovine Chromosome 14
Coppieters, Wouter ULg; Riquet, J.; Arranz, J. J. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1998), 9(7), 540-4

A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of ... [more ▼]

A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of a locus on the centromeric end of bovine Chromosome (Chr) 14, with major effect on fat and protein percentage as well as milk yield. The genuine nature of this QTL was verified using the grand2-daughter design, that is, by tracing the segregating QTL alleles from heterozygous grandsires to their maternal grandsons and confirming the predicted QTL allele substitution effect. [less ▲]

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See detailAspects de la gestion de clubs de football belges francophones. Comparaison en fonction du niveau de jeu
Cloes, Marc ULg; Chapelle, Jean-yves; Ledent, Maryse et al

in AES Magazine (1998), 52

Dans la société occidentale actuelle, les loisirs occupent une part extrêmement importante dans le style de vie de la majorité des individus. Bien que les loisirs soient caractérisés par une très grande ... [more ▼]

Dans la société occidentale actuelle, les loisirs occupent une part extrêmement importante dans le style de vie de la majorité des individus. Bien que les loisirs soient caractérisés par une très grande diversité, le sport figure parmi les activités qui y sont le plus fréquemment associés. Au fil des ans, le sport a pris de plus en plus d'importance, non seulement au point de vue de nombre de personnes concernées mais également au point de vue de l'implication financière qui résulte de sa pratique. ... [less ▲]

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See detailL'analyse en composantes principales : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1998), (2), 1-31

This note describes the principles of principal component analysis and gives two examples.

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See detailIGF-I and their binding proteins in growing horses.
Gerin, Daniele; Messina, Mariella; Renaville, Robert ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 34

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See detailCalcium binding protein calcyphosin in dog central astrocytes and ependymal cells and in peripheral neurons
Halleux, P.; Schurmans, Stéphane ULg; Schiffmann, S. N. et al

in Journal of Chemical Neuroanatomy (1998), 15

Calcyphosine is a calcium binding protein discovered in the dog thyroid in 1979. Calcyphosine mRNA and immunoreactivity were detected using Western and Northern blotting in the cerebral cortex, cerebral ... [more ▼]

Calcyphosine is a calcium binding protein discovered in the dog thyroid in 1979. Calcyphosine mRNA and immunoreactivity were detected using Western and Northern blotting in the cerebral cortex, cerebral white matter and cerebellum. Using immunohistochemistry and in situ hybridization, both are present in ependymal cells, choroid plexus cells and several types of astrocytes of the subependymal cerebral layer, the cerebellar Bergmann layer, the retinal ganglion cell layer, the optic nerve and the posterior pituitary. Both are also present in neurons of nasal olfactory mucosa, enteric Auerbach and Meissner plexuses, orthosympathic and spinal cord ganglia as well as in endocrine cells of neural crest origin in the adrenal medulla. Calcyphosine immunoreactive astrocytes were also present mainly in hemispheric cerebral gray and white matter, hemispheric subcortical structures, brain stem and spinal cord. These results show that calcyphosine is a characteristic calcium binding protein of astrocytes and ependymal cells in the central nervous system and of neurons in the peripheral nervous system. This is of interest in view of the importance of calcium regulation in these cells, and since calcyphosine a calcium binding protein phosphorylated by cAMP dependent process, may be an intermediate between cAMP and inositol phosphate cascades [less ▲]

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See detailMicrobiological control of apple postharvest diseases: a case of study
Jijakli, Haissam ULg; Lepoivre, Philippe ULg; Grevesse, C.

in revista corpoica (1998), 2

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See detailCalretinin expression as a critical component in the control of dentate gyrus long-term potentiation in mice
Gurden, H.; Schiffmann, S. N.; Lemaire, M. et al

in European Journal of Neuroscience (1998), 10

We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc ... [more ▼]

We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415 ). Here, we investigated dentate LTP induction in mice heterozygous (Cr+/–) for the same mutation. Despite the presence of calretinin in neurons of these mice, although at reduced levels as compared with normal mice, LTP induction in dentate gyrus was totally impaired. Spatial memory and learning were found unaffected in Cr+/– mice, such as in Cr–/– mice. Altogether, our results suggest that calretinin is a critical component in the control of dentate synaptic plasticity in mice, and that levels of calretinin higher than those observed in Cr+/– mice are required to induce LTP in this area. The possible mechanisms leading to the absence of correlation between gene dosage and biological effects are discussed [less ▲]

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See detailUne nouvelle tentative de commentaire de la strophe Yt 5. 7
Swennen, Philippe ULg

in Studia Iranica (1998), 27(2), 205-212

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See detailPharmaco-economie des medicaments hypolipidemiants: analyse des facteurs influencant le rapport cout/efficacite.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(5), 270-5

The demonstration that stains reduce the risk of cardiovascular diseases, in both secondary and primary prevention trials, led to the recent publication of sophisticated pharmaco-economical studies. A lot ... [more ▼]

The demonstration that stains reduce the risk of cardiovascular diseases, in both secondary and primary prevention trials, led to the recent publication of sophisticated pharmaco-economical studies. A lot of factors may influence the cost-effectiveness ratio of the pharmacological intervention, especially the mode of calculation of various costs, the initial level of cardiovascular risk of the patients and the medico-economical particularities of each country. What so ever, available studies appear to justify the use of statins in secondary prevention, i.e. in coronary patients, even those with only a moderate hypercholesterolaemia, and, in primary prevention, i.e in hypercholesterolaemia individuals with obvious high risk of cardiovascular disease. [less ▲]

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See detailTopological Model Of Membrane Domain Of The Cystic Fibrosis Transmembrane Conductance Regulator
Gallet, X.; Festy, F.; Ducarme, P. et al

in Journal of Molecular Graphics & Modelling (1998), 16(2), 97-8

The cystic fibrosis transmembrane conductance regulator is a cAMP-regulated chloride channel. We used molecular modelling to predict 3-D models for the CFTR membrane domain. Hydropathy and residue ... [more ▼]

The cystic fibrosis transmembrane conductance regulator is a cAMP-regulated chloride channel. We used molecular modelling to predict 3-D models for the CFTR membrane domain. Hydropathy and residue conservation in all CFTRs as well as in other proteins suggested that the membrane domain is a 12-helix bundle. If the domain is enclosing a channel for chloride, it could be made of five helices. We propose two structural models in which both lumenal and cytoplasmic entrances to the chloride pore have a ring of positively charged residues. The inner surface of the channel is covered with neutral polar plus one or two charged residues. Helices that are not directly involved in the chloride channel could organise to form a second channel; a dimeric symmetrical structure is proposed. Analysis raised interest for helix 5: this hydrophobic fragment is conserved in all CFTRs and aligns with segments present in several different ion channels and transporters. The existence of an FFXXFFXXF motif is proposed. Helix 5 could be an important domain of CFTRs. The models agree with available data from pathological mutations but does not account for the membrane insertion of a hydrophilic fragment of NBDI. [less ▲]

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See detailTexture control of freeze-dried resorcinol-formaldehyde gels
Kocklenberg, Régine; Mathieu, Bernard; Blacher, Silvia ULg et al

in Journal of Non-Crystalline Solids (1998), 225

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See detailInfluence Of The Mode Of Insertion Of Siv Peptides Into Membranes On The Structure Of Model Membrane As Studied By P-31 Nmr
Schanck, A.; Peuvot, J.; Brasseur, Robert ULg

in Biochemical and Biophysical Research Communications (1998), 250(1), 12-4

The influence on model membrane organization of a fusion peptide of SIV and of a nonfusogenic mutant of this peptide was examined by molecular modeling and by 31P NMR. The calculated mode of insertion of ... [more ▼]

The influence on model membrane organization of a fusion peptide of SIV and of a nonfusogenic mutant of this peptide was examined by molecular modeling and by 31P NMR. The calculated mode of insertion of the fusion peptide shows that it adopts an oblique orientation towards the lipid-water interface and that this fusion peptide induces a destabilization of the bilayer structure of multilamellar vesicles as evidenced by 31P NMR observations. The SIV mutant showing a more vertical insertion into lipid layers is unable to induce nonlamellar structures. This study reinforces the correlation between fusogenic activity, induction of structures not organized in extended bilayers, and calculated mode of insertion of peptides into lipid layers. [less ▲]

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