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See detailBooklist 1997
Pirenne, Christophe ULg; Mitsui, Toru

in Popular Music (1998), 17(3), 359-383

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See detailTranscription factor AP1 is involved in basal and okadaic acid-stimulated activity of the human PRL promoter
Caccavelli, Laure; Manfroid, Isabelle ULg; Martial, Joseph ULg et al

in Molecular Endocrinology (Baltimore, Md.) (1998), 12(8), 1215-27

The tumor promoter, okadaic acid (OA), an inhibitor of protein phosphatases, stimulates the activity of the human PRL (hPRL) proximal promoter. We analyzed in detail the effects of OA on transcription ... [more ▼]

The tumor promoter, okadaic acid (OA), an inhibitor of protein phosphatases, stimulates the activity of the human PRL (hPRL) proximal promoter. We analyzed in detail the effects of OA on transcription factor binding to elements P1 and P2 of this promoter, sequences known to contain at least one Pit-1 binding site each. OA treatment induces binding of an AP1-related transcription factor to the P1 site. This effect is specific, as protein binding to the P2 site is not altered by the treatment. Specific antibodies were used to confirm that the OA-induced complex is related to AP1 and to show that it contains JunD and c-fos, but not Pit-1. The increase in AP1 binding to P1 and to a canonical AP1 site correlates to an increase in cellular JunD and c-fos content. Transient transfection experiments showed that both AP1 and Pit-1 are involved in the regulation of basal and OA-stimulated promoter activity. Our results demonstrate that a member of the AP1 family, containing JunD and c-fos, can bind to the proximal element P1 within the hPRL promoter. In addition, they show that AP1 is involved in both basal and OA-stimulated expression of the hPRL gene. [less ▲]

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See detailThe influence of sugar-beet fibre, guar gum and inulin on nutrient digestibility, water consumption and plasma metabolites in healthy Beagle dogs.
Diez, Marianne ULg; Hornick, Jean-Luc ULg; Baldwin, Paule ULg et al

in Research in Veterinary Science (1998), 64(2), 91-6

The aim of the present study was to evaluate the effects of three fibres (sugar-beet fibre, guar gum and inulin) incorporated in the basal diet of healthy dogs at 7 per cent of dry matter (DM). Parameters ... [more ▼]

The aim of the present study was to evaluate the effects of three fibres (sugar-beet fibre, guar gum and inulin) incorporated in the basal diet of healthy dogs at 7 per cent of dry matter (DM). Parameters examined included stool output, water consumption, nutrient digestibility and fasting and postprandial plasma metabolites. All fibres increased wet faecal output; an increase in faecal DM output being observed with sugar-beet fibre only. Sugar-beet fibre and inulin increased daily water consumption. Sugar-beet fibre and guar gum decreased DM digestibility. The three fibres diminished organic matter and crude protein digestibility while ether extract digestibility was decreased by guar gum and inulin. Guar gum induced lower postprandial insulin, alpha-amino-nitrogen and urea plasma concentrations. Guar gum also lowered fasting cholesterolaemia. Sugar-beet fibre and inulin showed no metabolic effects. These physiological properties suggest that guar gum would be a suitable ingredient for dietary therapy of chronic diseases such as diabetes mellitus or hyperlipidaemia in the dog. [less ▲]

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See detailDoes an Acute COPD Crisis Modify the Cardiorespiratory and Ventilatory Adjustments to Exercise in Horses?
Art, Tatiana ULg; Duvivier, Dominique Hannia; Votion, Dominique ULg et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1998), 84(3), 845-52

The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD ... [more ▼]

The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD horses were submitted to a standardized submaximal treadmill exercise test while they were in clinical remission or in acute crisis. Respiratory airflow, O2 and CO2 fractions in the respired gas, pleural pressure changes and heart rate were recorded, and arterial and mixed venous blood were analyzed for gas tensions, hemoglobin, and plasma lactate concentrations. O2 consumption, CO2 production, expired minute ventilation, tidal volume, alveolar ventilation, cardiac output, total pulmonary resistance, and mechanical work of breathing were calculated. The results showed that, when submaximally exercised, COPD horses in crisis were significantly more hypoxemic and hypercapnic and that their total pulmonary resistance and mechanical work of breathing were significantly higher and their expired minute ventilation significantly lower than when they were in remission. However, their O2 consumption remained unchanged, which was probably due to the occurrence of compensatory mechanisms, i.e., higher heart rate, cardiac output, and hemoglobin concentration. Last, their net anaerobic metabolism seemed to be more important. [less ▲]

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See detailTarifs de cubage pour l'aulne glutineux (Alnus Glutinosa (L.) Gaertn.) en Belgique méridionale
Thibaut, André; Rondeux, Jacques ULg; Claessens, Hugues ULg

in Revue Forestière Française (1998), 50(3), 244-250

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See detailClinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure.
Eisele, Bernd; Lamy, Maurice ULg

in Seminars in Thrombosis & Hemostasis (1998), 24(1), 71-80

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years ... [more ▼]

Despite improvements in critical care medicine and the development and aggressive use of potent broad-spectrum anti-microbial agents, mortality due to severe sepsis has not changed during the recent years and still comes to 35% to 45%. For quite a long time our understanding of the pathophysiology of sepsis was mainly focused on endotoxin and proinflammatory cytokines like tumor necrosis factor or interleukin-1. Now it is generally accepted that many signs and symptoms of sepsis are not directly mediated by cytokines but are transmitted through other mediator systems. The coagulation system comes into play especially when the septic process progresses to malperfusion and organ failure. Antithrombin III is an important inhibitor of the intrinsic, extrinsic and common pathway of coagulation. Recently, evidence has been accumulating that there is an additional anti-inflammatory potential of the drug. Currently there are several clinical trials ongoing to investigate whether this effect is of clinical relevance in the treatment of patients with severe sepsis. [less ▲]

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See detailLes thiazolidinediones : quel avenir dans le traitement du diabète de type 2 ?
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (1998), 56

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See detailHorseradish peroxidase electrode for phenothiazine analysis
Petit, C.; Quilinc, A.; Quilinc, E. et al

in Electroanalysis (1998), 10

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See detailDynamical atomic charges: The case of ABO(3) compounds
Ghosez, Philippe ULg; Michenaud, J. P.; Gonze, X.

in Physical Review. B : Condensed Matter (1998), 58(10), 6224-6240

Based on recent first-principles computations in perovskite compounds, especially BaTiO3, we examine the significance of the Born effective charge concept and contrast it with other atomic charge ... [more ▼]

Based on recent first-principles computations in perovskite compounds, especially BaTiO3, we examine the significance of the Born effective charge concept and contrast it with other atomic charge definitions, either static (Mulliken, Bader, etc.) or dynamical (Callen, Szigeti, etc.). It is shown that static and dynamical charges are not driven by the same underlying parameters. A unified treatment of dynamical charges in periodic solids and large clusters is proposed. The origin of the difference between static and dynamical charges is discussed in terms of local polarizability and delocalized transfers of charge: local models succeed in reproducing anomalous effective charges thanks to large atomic polarizabilities but, in ABO(3) compounds, ab initio calculations favor the physical picture based upon transfer of charges. Various results concerning barium and strontium titanates are presented. The origin of anomalous Born effective charges is discussed thanks to a band-by-band decomposition which allows us to identify the displacement of the Wannier center of separated bands induced by an atomic displacement. The sensitivity of the Born effective charges to microscopic and macroscopic strains is examined. Finally, we estimate the spontaneous polarization in the four phases of barium titanate. [less ▲]

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See detailDistinctive Anatomical Features of the Branchial Basket in four Carapidae Species (Ophidiiformi, Paracanthopterygii)
Vandewalle, Pierre ULg; Parmentier, Eric ULg; Poulicek, Mathieu ULg et al

in European Journal of Morphology (1998), 36(3), 153-164

The present study focuses on the branchial basket in four Carapidae species: Carapus acus , Encheliophis boraborensis , Encheliophis homei and Encheliophis gracilis . The aim is to highlight the skeletal ... [more ▼]

The present study focuses on the branchial basket in four Carapidae species: Carapus acus , Encheliophis boraborensis , Encheliophis homei and Encheliophis gracilis . The aim is to highlight the skeletal and muscular features of the branchial basket, especially those that are believed to be related to their way of life and/or to be linked to the presence of primary sound-producing muscles. The space occupied by the primary sound-producing muscles between the neurocranium and the branchial basket gives rise to distinctive skeletal and muscular features. They prevent the 1st pharyngobranchials from becoming attached to the neurocranium in the normal way. These do not seem to play any role in the suspension of the upper pharyngeal jaws, as it is usually the case in teleosteans. The 1st epibranchials are separated from the 2nd pharyngobranchials. Ossified interarcual elements jointed to the 2nd pharyngobranchials and 1st epibranchials are found in the position usually occupied by the latter. The presence of primary sound-producing muscles gives rise to the need for the reorganisation of the musculature which is seen in particular with regards to the levatores branchiales. These are not found on the neurocranium but on the hyomandibular. The general skeletal and muscular data and the observations of the stomach contents suggest that the action of the branchial basket is restricted to carrying food in Carapus acus , Encheliophis boraborensis and Encheliophis homei , whereas it could also play a role in the work of cutting up soft food in Encheliophis gracilis . [less ▲]

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See detailLa communication dans la démocratie du 3e millénaire
Vromans, Joseph ULg

in Actes de la XXième Session de l'Institut d'Etudes Mondialistes (1998)

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See detailAsymptotic stability conditions for time-variant systems and observability : uniform and non-uniform criteria
Aeyels, D.; Sepulchre, Rodolphe ULg; Peuteman, J.

in Mathematics of Control, Signals & Systems (1998), 11

This paper presents some new criteria for uniform and non uniform asymtotic stability of equilibria for time-variant differential equations and this within a Liapunov approach. The stability criteria are ... [more ▼]

This paper presents some new criteria for uniform and non uniform asymtotic stability of equilibria for time-variant differential equations and this within a Liapunov approach. The stability criteria are formulated in terms of certain observability conditions with the output derived from the Liapunov function. For some classes of systems, this system theoretic interpretation proves to be fruitful since - after establishing the invariance of observability under output injection - this enables us to check the stability criteria on a simpler system. This procedure is illustrated for some classical examples. [less ▲]

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See detailCloches et carillons dans les Principautés de Liège et Stavelot-Malmedy. Richesse et actualité du patrimoine campanaire
Marganne, Marie-Hélène ULg; Mélard, Marc

in Feuillets de la Cathédrale de Liège (1998), 33-38

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See detailEffects of an enriched environment on subsequent fear reactions of lambs and ewes.
Vandenheede, Marc ULg; Bouissou, Marie-France

in Developmental Psychobiology (1998), 33(1), 33-45

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See detailHemovigilance: Clinical Tolerance of Solvent-Detergent Treated Plasma
Baudoux, Etienne ULg; Margraff, U.; Coenen, Alain ULg et al

in Vox Sanguinis (1998), 74(Suppl 1), 237-9

OBJECTIVE: This study was conducted to assess retrospectively the clinical tolerance of SD treated plasma and to compare it to other labile blood products (red blood cell and platelet concentrates ... [more ▼]

OBJECTIVE: This study was conducted to assess retrospectively the clinical tolerance of SD treated plasma and to compare it to other labile blood products (red blood cell and platelet concentrates). METHODS: Adverse events (AEs) related to the use of blood products at the Blood Transfusion Center (BTC) are routinely collected through a formalised system of hemovigilance. All AEs reported are entered into a safety data base which was used for the study. All AEs reported during a one-year period to the BTC were retrospectively re-assessed and descriptive statistics calculated. RESULTS: 5064 units of SD treated plasma were transfused to 894 recipients during the study period at the occasion of 1553 transfusions. No AE associated to SD treatment plasma was reported during that period. In contrast, during the same period, 485 AEs associated with the use of red blood cell concentrates (RBCC) were reported in 251 patients at the occasion of 262 transfusions. 2.1% (251/11,748) of the patients transfused with RBCC experienced one or more AEs. The incidence of AEs per unit transfused was 1.3% (485/37,332), and 2.4% (485/20,460) of RBCC transfusions were associated with one or more AEs. 142 AEs associated with the use of platelet concentrate (PC) were observed in 69 patients at the occasion of 73 transfusions. 4.2% (69/1645) of patients transfused with PC experienced one or more AEs. The incidence of AEs per unit transfused was 1.1% (142/12,772), and 2.8% (142/5034) of PC transfusions were associated with one or more AEs. All reported AEs were classified and non serious. The most frequently observed AEs were fever, chills and rashes which accounted for roughly 64% of all reported AEs. CONCLUSION: As for the overall clinical tolerance of red cell and platelet concentrates, the results of this study are in complete agreement with the published literature. The study also confirms the extremely good tolerability of SD treated plasma in comparison with other labile blood products. [less ▲]

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See detailHST observations of the QSO pair Q1026-0045A,B
Petitjean, Patrick; Surdej, Jean ULg; Smette, Alain et al

in Astronomy and Astrophysics (1998), 334

The spatial distribution of the Lyalpha forest is studied using new HST data for the quasar pair Q 1026-0045 A and B at z_em = 1.438 and 1.520 respectively. The angular separation is 36 arcsec and ... [more ▼]

The spatial distribution of the Lyalpha forest is studied using new HST data for the quasar pair Q 1026-0045 A and B at z_em = 1.438 and 1.520 respectively. The angular separation is 36 arcsec and corresponds to transverse linear separations between lines of sight of ~ 300h(-1}_{50) kpc (q_o = 0.5) over the redshift range 0.833 < z < 1.438. From the observed numbers of coincident and anti-coincident Lyalpha absorption lines, we conclude that, at this redshift, the Lyalpha structures have typical dimensions of ~ 500h(-1}_{50) kpc, larger than the mean separation of the two lines of sight. The velocity difference, Delta V, between coincident lines is surprisingly small (4 and 8 pairs with Delta V < 50 and 200 km s(-1) respectively). Metal line systems are present at z_abs = 1.2651 and 1.2969 in A, z_abs = 0.6320, 0.7090, 1.2651 and 1.4844 in B. In addition we tentatively identify a weak Mg ii system at z_abs = 0.11 in B. It is remarkable that the z_abs = 1.2651 system is common to both lines of sight. The system at z_abs = 1.4844 has strong O vi absorption. There is a metal-poor associated system at z_abs = 1.4420 along the line of sight to A with complex velocity profile. We detect a strong Lyalpha absorption along the line of sight to B redshifted by only 300 km s(-1) relatively to the associated system. It is tempting to interpret this as the presence of a disk of radius larger than 300h(-1}_{50) kpc surrounding quasar A. Based on observations obtained with the NASA/ESA Hubble Space Telescope by the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS 5-26555 [less ▲]

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See detailFunctional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family
Poncelet, Dominique A.; Bellefroid, Eric J.; Bastiaens, P. V. et al

in DNA & Cell Biology (1998), 17(11), 931-43

We previously identified the ZNF85 (HPF4) KRAB zinc finger gene, a member of the human ZNF91 family. Here, we show that the ZNF85 gene is highly expressed in normal adult testis, in seminomas, and in the ... [more ▼]

We previously identified the ZNF85 (HPF4) KRAB zinc finger gene, a member of the human ZNF91 family. Here, we show that the ZNF85 gene is highly expressed in normal adult testis, in seminomas, and in the NT2/D1 teratocarcinoma cell line. Immunocytochemical localization of a panel of beta-Gal/ZNF85 fusion proteins revealed that ZNF85 contains at least one nuclear localization signal located in the spacer region connecting the KRAB domain with the zinc finger repeats. Bacterially expressed ZNF85 zinc finger domain bound strongly and exclusively to DNA in vitro in a zinc-dependent manner. The KRAB(A) domain of the ZNF85 protein and of several other members of the ZNF91 family exhibited repressing activity when tested in Gal4 fusion protein assays. The repression was significantly enhanced by the addition of the KRAB (B) domain, whereas further addition of other conserved regions had no effect. The ZNF85 KRAB(A) and (B) domains in vitro bound several nuclear proteins that might constitute critical cofactors for repression. [less ▲]

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See detailUltrastructural distribution of DNA within plant meristematic cell nucleoli during activation and the subsequent inactivation by a cold stress.
Mineur, Pierre ULg; Jennane, A.; Thiry, Marc ULg et al

in Journal of Structural Biology (1998), 123(3), 199-210

We have investigated the precise location of DNA within the meristematic cell nucleolus of Zea mays root cells and Pisum sativum cotyledonary buds, in the course of their activation and induced ... [more ▼]

We have investigated the precise location of DNA within the meristematic cell nucleolus of Zea mays root cells and Pisum sativum cotyledonary buds, in the course of their activation and induced inactivation following a subsequent treatment at low temperature. For this purpose, we combined the acetylation method, providing an excellent distinction between the various nucleolar components, with the in situ terminal deoxynucleotidyl transferase-immunogold technique, a highly sensitive method for detecting DNA at the ultrastructural level. In addition to the presence of DNA in the condensed chromatin associated with the nucleolus, we demonstrated that a significant label was detected in the nucleolus of quiescent cells in both plant models. Evident labels were also found in the dense fibrillar component of actived nucleoli. Whereas in inactivated nucleoli no significant label was observed within the dense fibrillar component, an intense label was seen over the large heterogeneous fibrillar centres only during inactivation. The granular component was never significantly labelled. These results appear to indicate that the DNA present in the dense fibrillar component of activated nucleoli withdraws from this structure during its inactivation and becomes incorporated in the large fibrillar centres. These observations suggest that in plant cells inactivation of rRNA genes is clearly accompanied by changes in the conformation of ribosomal chromatin. [less ▲]

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See detailLe logement des vaches laitières
Nicks, Baudouin ULg

in Annales de Médecine Vétérinaire (1998), 142(6), 413-416

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See detailElectrodeposition of metals and magnetic alloys onto conducting polymeric substrates
Leroy, D.; Martinot, Lucien; Licour, C. et al

in Journal De Chimie Physique Et De Physico-Chimie Biologique (1998), 95(6), 1491-1493

A new composite material prepared by mixing polycarbonate with carbon black has been tested as new kind of cathode, This material has been compared with a conducting polymer precipitated onto ... [more ▼]

A new composite material prepared by mixing polycarbonate with carbon black has been tested as new kind of cathode, This material has been compared with a conducting polymer precipitated onto polycarbonate, both in aqueous and organic solutions. We report some examples of electrodeposition of magnetic alloys (Lanthanides/Transition metals) in Formamide, In this medium, the use of thin polypyrrole films cathodes had remained impossible, The preparation of amorphous and magnetic alloys onto PC/carbon black is evidenced by RES. [less ▲]

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See detailMRI of a presumptive trigeminal nerve tumor in a seven years old husky dog : a case report and review of the litterature
Saunders, J.; Clercx, Cécile ULg; Poncelet, Luc et al

in Veterinary Radiology & Ultrasound (1998), 39

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See detailQuantification by PIXE of metallic sites in proteins separated by electrophoresis
Strivay, David ULg; Schoefs, B.; Weber, Georges ULg

in Nuclear Instruments & Methods in Physics Research Section B (1998), 137

Electrophoresis on polyacrylamide gel (PAGE) is widely used in life sciences to determine the molecular weight of proteins in solution by separating them into different bands. By coupling electrophoresis ... [more ▼]

Electrophoresis on polyacrylamide gel (PAGE) is widely used in life sciences to determine the molecular weight of proteins in solution by separating them into different bands. By coupling electrophoresis and Particle Induced W-ray Emission (PIXE), the nature and the quantity of metals contained in proteins can be investigated. After the electrophoresis, the gel is dried and each track is scanned with a 2.5 MeV proton beam which induces X-ray emission. Analysis of these spectra allows the determination of the metals contained in an electrophoretic band. The metal content in each band is obtained by comparing the characteristic X-ray peak area with those obtained with polyacrylamide gels doped with the same metal. Finally, the relative concentration of each protein is determined by densitometry in order to compute the protein/metal ratio. An example of metallic site determination is presented. This procedure seems to be a very useful multielementary method for the determination of the metal amounts inside proteins after their separation by electrophoresis. Furthermore it allows to check if metals remain bound to proteins. (C) 1998 Elsevier Science B.V. [less ▲]

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See detailA comparison between the TEC computed using GPS and ionosonde measurements
Warnant, René ULg; Jodogne, Jean-Claude

in Acta Geodaetica et Geophysica Hungarica (1998), 33(1), 147-153

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See detailTétanie, spasmophilie, syndrome d'hyperventilation : synthèse théorique et thérapeutique.
Delvaux, Muriel ULg; Fontaine, Philippe; Bartsch, Pierre ULg et al

in Revue Médicale de Liège (1998), 53

Le syndrome d’hyperventilation(SHV), caractérisé par des symptômes somatiques multiples induits par une hyperventilation inappropriée, constitue la description physiopathologique d’un trouble fréquent en ... [more ▼]

Le syndrome d’hyperventilation(SHV), caractérisé par des symptômes somatiques multiples induits par une hyperventilation inappropriée, constitue la description physiopathologique d’un trouble fréquent en médecine générale. Synonyme de spasmophilie, ou encore de tétanie normocalcique, il présente l’avantage de proposer des critères diagnostiques, même si ceux-ci sont encore vagues. Mais sa définition permet des mesures objectives : en effet, on peut facilement quantifier la chute de PCO2 lors d’un test de provocation d’hyperventilation, ou la PCO2 anormalement basse au repos. Le concept de syndrome d’hyperventilation propose également un traitement structuré (rééducation respiratoire, psychothérapie et pharmacologie) et efficace. Malgré tout, il subsiste certaines incertitudes scientifiques à son sujet. Il n’existe pas de consensus concernant les critères à prendre en compte lors d’un test de provocation d’hyperventilation pour diagnostiquer un syndrome d’hyperventilation ; la spécificité de ce test est faible et un placebo (hyperventilation isocapnique) peut induire autant de symptômes que lui. La rééducation respiratoire, si elle donne de bons résultats, n’agit pas pour autant nécessairement sur la PCO2. Certains y voient uniquement un mécanisme de relaxation et une explication rationnelle aux symptômes effrayants. Tout ceci pousse certains auteurs à rejeter le terme « syndrome d’hyperventilation », pour préférer celui «d’hyperventilation chronique de cause inconnue ». [less ▲]

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See detailApproach to the use of immobilizer sulfatase for analytical purposes and for the pràoduction of desulfo-glucosinolates
Wathelet, Jean-Paul ULg

in Industrial Crops & Products (1998), 7

A commercial crude sulfatase from snail (Helix pomatia) was purified by ion exchange affinity, HPLC, gel-filtration chromatography. The enzyme isolated. which was ca. 37-folcl more active than the ... [more ▼]

A commercial crude sulfatase from snail (Helix pomatia) was purified by ion exchange affinity, HPLC, gel-filtration chromatography. The enzyme isolated. which was ca. 37-folcl more active than the commercial one was covalently immobilizcd on nyon 6.6 by the cross linking method. Immobilized sulfatase was usecl to produce some desulfo-glucosinolates (DSGLs) on the gram-scale. starting fiom glucotropaeolin. glucoraphenin ancl épiprogoitrin ancl for HPLC analyses of glucosinolates (GLs) containecl in cruciferous material and rapeseecl in particular. The immobilized enzyme as well as allowing the standarclization of the HPLC methocl for GLs analysis seems to be an efflcient system for producing DSGLs which are interesting starting materials to prepare bio-active structures through further chemical modilications. [less ▲]

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See detailFrancorchamps, le juge et la loi
Abu Dalu, Firass ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

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See detailLe Forestor Vertex: une nouvelle génération de dendromètres.
Rondeux, Jacques ULg; Pauwels, D.

in Revue Forestière Française (1998), 50(1), 59-64

The new generation of hypsometers, of which the Swedish Forestor Vertex is representative, use ultrasonic pulses to determine heights from 0 to 100 m, as well as distances and angles. The authors describe ... [more ▼]

The new generation of hypsometers, of which the Swedish Forestor Vertex is representative, use ultrasonic pulses to determine heights from 0 to 100 m, as well as distances and angles. The authors describe the operating principle for this hypsometer and point out some precautions that should be taken when using it. They highlight its main advantages and provide data on its precision. [less ▲]

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See detailSciences et Médecine à Liège à l'aube du troisième millénaire
Legros, Willy ULg; Rentier, Bernard ULg

in M S-Médecine Sciences (1998), 14(5), 535-536

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See detailParathyroid hormone plasma concentrations in response to low 25-OH vitamin D circulating levels increases with age in elderly women.
Reginster, Jean-Yves ULg; Frederick, I.; Deroisy, Rita ULg et al

in Osteoporosis International (1998), 8(4), 390-2

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See detailFunctional brain imaging of human sleep
Maquet, Pierre ULg; Phillips, Christophe ULg

in Journal of Sleep Research (1998), 7(Suppl. 1), 42-47

This paper presents an overview of the contribution of functional brain mapping to the study of human sleep. Early studies were essentially successful in describing the variations of the global level of ... [more ▼]

This paper presents an overview of the contribution of functional brain mapping to the study of human sleep. Early studies were essentially successful in describing the variations of the global level of cerebral metabolism. More recently, regional distribution of cerebral blood flow was reported. The results suggest that the permissive and executive processes of slow wave sleep and REM sleep are similar in humans and in animals. They also show cortical blood flow distributions specific to each sleep stage. The cellular mechanisms underlying the involvement of these cortical areas in sleep are not yet precisely known. They should be looked for by further investigations in animals. Future research in functional neuroimaging will attempt to explore functional and, hopefully, effective connectivity between cerebral areas involved in sleep processes. This final goal will probably require the co-registration of two or more brain imaging techniques to precisely describe the spatio-temporal course of neuronal interactions occurring during sleep. [less ▲]

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See detailEnseignants de français et d'histoire. Mieux se connaître pour mieux collaborer
Jadoulle, Jean-Louis ULg

in Français 2000 (1998), n°161-162

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See detailSanté et environnement : analogies dans les approches sociologiques
Mougenot, Catherine ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(2), 96-105

Ce texte repose sur l'idée qu'il peut exister bon nombre d'homologies entre les questions de recherche en sciences sociales sur la santé et sur l'environnement. On cherchera à donner corps à cette ... [more ▼]

Ce texte repose sur l'idée qu'il peut exister bon nombre d'homologies entre les questions de recherche en sciences sociales sur la santé et sur l'environnement. On cherchera à donner corps à cette intuition sur base d'une recension récente de textes portant sur la santé, en les présentant à partir de trois thématiques non totalement dispointes. La santé et l'environnement reposent largement sur des représentations collectives qui, même si elles restent floues, n'en sont pas moins efficaces, socialement. Une seconde thématique concerne la prévention, tout aussi essentielle en matière de santé que d'environnement. Enfin, force est de constater que dans ces deux domaines, la place de la science et le rôle des scientifiques sont incontournables. Comment peut-on les caractériser ? C'est ce que cherchent à accompagner des notions récentes en sociologie. [less ▲]

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See detailATMOS/ATLAS 3 infrared profile measurements of clouds in the tropical and subtropical upper troposphere
Rinsland, C. P.; Gunson, M. R.; Wang, P.-H. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (1998), 60(5), 903-919

Vertical profiles of infrared cirrus extinction have been derived from tropical and subtropical upper tropospheric solar occultation spectra. The measurements were recorded by the Atmospheric Trace ... [more ▼]

Vertical profiles of infrared cirrus extinction have been derived from tropical and subtropical upper tropospheric solar occultation spectra. The measurements were recorded by the Atmospheric Trace Molecule Spectroscopy (ATMOS) Fourier transform spectrometer during the Atmospheric Laboratory for Applications and Sciences (ATLAS) 3 shuttle flight in November 1994. The presence of large numbers of small ice crystals is inferred from the appearance of broad extinction features in the 8-12 mu m region. These features were observed near the tropopause and at lower altitudes. Vertical profiles of the ice extinction (km(-1)) in microwindows at 831, 957, and 1204 cm(-1) have been retrieved from the spectra and analyzed with a model for randomly oriented spheroidal ice crystals. An area-equivalent spherical radius of 6 mu m is estimated from the smallest ice crystals observed in the 8-12 mu m region. Direct penetration of clouds into the lower stratosphere is inferred from observations of cloud extinction extending from the upper troposphere to 50 mbar (20 km altitude). Cloud extinction between 3 and 5 mu m shows very little wavelength dependence, at least for the cases observed by the ATMOS instrument in the tropics and subtropics during ATLAS 3. Published by Elsevier Science Ltd. [less ▲]

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See detailInsulin-like growth factor-I (IGF-I), IGF-binding proteins synthesis, and thyroid status are affected by dexamethasone esters treatment in finishing calves
Bertozzi, Carlo; Massart, Serge; Prandi, Alberto et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 45

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See detailDéveloppement d’un système de séchage contrôlé de faible consommation énergétique à embarquer sur des bateaux de pêche de petites dimensions ou à installer au sol, proche d’une source d’énergie existante
Marchal, Jean ULg; Rodriguez, S.

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (1998), Nouvelle Série 44 (3)(4ème trimestre), 425-443

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See detailSuperconducting properties of natural and artificial grain boundaries in bulk melt-textured YBCO
Vanderbemden, Philippe ULg; Bradley, A. D.; Doyle, R. A. et al

in Physica C: Superconductivity (1998), 302(4), 257-270

A range of experimental techniques have been used to characterize melt-processed YBa2Cu3O7-d samples containing single-grain boundaries. Both natural high-angle boundaries, which sometimes appear during ... [more ▼]

A range of experimental techniques have been used to characterize melt-processed YBa2Cu3O7-d samples containing single-grain boundaries. Both natural high-angle boundaries, which sometimes appear during the grain growth process, and artificial low-angle boundaries, obtained by joining two single domains, have been investigated. Electrical resistivity, current-voltage characteristics, magnetic moment measurements and Hall probe mapping techniques have been employed to investigate the boundaries. Results are compared with the properties of single domain material (i.e., containing no grain boundary) for which T-c approximate to 89 K and J(c)parallel to ab (77 K, 1 T) > 10^4 A/cm(2). Resistance measurements across all the grain boundaries show a stronger dependence on current and magnetic field than that measured within the grains and exhibit a pronounced resistive 'tail'. The I-V curves obtained for the high-angle natural grain boundary are sharp and differ from the rounded I-V curves which are characteristic of single-grains. Field mapping measurements used to evaluate the critical current anisotropy are in agreement with magnetisation measurements. The limitations of this technique for investigating boundaries are discussed. It was found that current anisotropy can conceal a weak link between two grains, leading to a false indication of single-grain behaviour. Artificially engineered boundaries are shown to have significant potential for applications in high fields at 77 K. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailATMOS/ATLAS 3 infrared profile measurements of trace gases in the November 1994 tropical and subtropical upper troposphere
Rinsland, C. P.; Gunson, M. R.; Wang, P.-H. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (1998), 60(5), 891-901

Vertical mixing ratio profiles of four relatively long-lives gases, HCN, C2H2, CO, and C2H6, have been retrieved from 0.01 cm(-1) resolution infrared solar occultation spectra recorded between latitudes ... [more ▼]

Vertical mixing ratio profiles of four relatively long-lives gases, HCN, C2H2, CO, and C2H6, have been retrieved from 0.01 cm(-1) resolution infrared solar occultation spectra recorded between latitudes of 5.3 degrees N and 31.4 degrees N. The observations were obtained by the Atmospheric Trace Molecule Spectroscopy (ATMOS) Fourier transform spectrometer during the Atmospheric Laboratory for Applications and Science (ATLAS) 3 shuttle flight, 3-12 November 1994. Elevated mixing ratios below the tropopause were measured for these gases during several of the occultations. The positive correlations obtained between the simultaneously measured mixing ratios suggest that the enhancements are likely the result of surface emissions, most likely biomass burning and/or urban industrial activities, followed by common injection via deep convective transport of the gases to the upper troposphere. The elevated levels of HCN may account for at least part of the "missing NOy" in the upper troposphere. Comparisons of the observations with values measured during a recent aircraft campaign are presented. Published by Elsevier Science Ltd. [less ▲]

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See detailCytokinins and ethylene stimulate indole alkaloid accumulation in cell suspension cultures of Catharanthus roseus by two distinct mechanisms
Yahia, Abdelouahab; Kevers, Claire ULg; Gaspar, Thomas ULg et al

in Plant Science (1998), 133(1), 9-15

The interactions between cytokinins and ethylene on alkaloid accumulation in a periwinkle cell line have been examined. It was found that (a) either exogenously-applied cytokinins or ethylene (the latter ... [more ▼]

The interactions between cytokinins and ethylene on alkaloid accumulation in a periwinkle cell line have been examined. It was found that (a) either exogenously-applied cytokinins or ethylene (the latter through ethephon degradation) greatly enhanced ajmalicine accumulation in cells subcultured in a 2,4-dichlorophenoxyacetic acid-free medium; (b) the enhancing effect of cytokinin was not mediated by enhancement of endogenous ethylene production contrary to what is found in some plant models, (c) the responses to exogenous cytokinin and ethylene were additive and showed a different pattern of expression. It may be concluded that cytokinin and ethylene can up-regulate the alkaloid production in a periwinkle cells through independent pathways when added exogenously to the cultures. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailInfluence du caractere culard sur la production et la qualité de la viande des bovins Blanc Bleu Belge
Clinquart, Antoine ULg; Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg et al

in Productions Animales (1998), 11(4), 285-297

When compared to animals of the dual purpose type in the same breed, Belgian Blue double muscled bulls exhibit, at least, similar average daily gain with lower feed intake. The higher feed efficiency in ... [more ▼]

When compared to animals of the dual purpose type in the same breed, Belgian Blue double muscled bulls exhibit, at least, similar average daily gain with lower feed intake. The higher feed efficiency in the double muscled type is mainly explained by the composition of the weight gains, the muscle content is minimum 60 kg higher and the fat content 30 kg lower than in the dual purpose type when slaughtered at a similar liveweight. In both types, the dressing percentage and the lean meat proportion in the carcass increase with final liveweight.The chemical composition and the sensory characteristics of meat are also influenced by double muscling. The fat content is reduced and the polyunsaturated fatty acids proportion is increased in the double muscled type, resulting in a nutritional advantage. The difference in sensory characteristics could be, only partially, explained by the faster post mortem pH drop. The paler meat is mainly related to the myoglobin content. The advantage of the double muscled type in terms of tenderness, due to a low collagen content, is not exhibited in a "choice" cut of the carcass with a low level of collagen. Finally, according to most of the available data, the water holding capacity of meat of double muscled animals seems not very different.The concentrations of several blood metabolites indicate a partition of the absorbed nutrients propitious to protein deposition and unpropitious to fat deposition in double muscled animals. During the fattening period, this specific partition can be related to endocrine characteristics, mainly growth hormone and insulin. [less ▲]

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See detailThymic expression of neuroendocrine self-peptide precursors: role in T-cell survival and self-tolerance
Geenen, Vincent ULg; Kecha, Ouafae; Martens, Henri ULg

in Journal of Neuroendocrinology (1998), 10

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See detailVirulence Plasmids of Enterotoxigenic Escherichia Coli Isolates from Piglets
Mainil, Jacques ULg; Daube, Georges ULg; Jacquemin, Etienne et al

in Veterinary Microbiology (1998), 62(4), 291-301

Virulence plasmids of 68 ETEC isolates from piglets belonging to different pathotypes and six ETEC isolates from calves with pathotypes typical of porcine ETEC were identified with seven virulence probes ... [more ▼]

Virulence plasmids of 68 ETEC isolates from piglets belonging to different pathotypes and six ETEC isolates from calves with pathotypes typical of porcine ETEC were identified with seven virulence probes for the heat-stable (STa and STb) and heat-labile (LT) enterotoxins, for the F4, F5, F6, and F41 fimbrial adhesion subunit, and also with five Rep probes for the RepFIA and RepFIB basic replicons, and the RepFIC family of basic replicons. With the exception of the F41 probe, the other virulence probes hybridized with at least one plasmid band of a size range from 65 to more than 100 Mda. Common associations of virulence factor-encoding genes on plasmid bands were: STb/LT, STa/F5, STa/F6, STa/STb. Other associations, STa/F4, STa/F4/F6, and STa/STb/LT/F6, were rarer. On the other hand the F4 adhesin-encoding genes were isolated on one plasmid band in all but three F4+ isolates. All but one of the 92 virulence plasmids which were studied have Rep probe hybridization profiles and replicon types typical of the uni- or multireplicon plasmids belonging to the various incompatibility groups of the F incompatibility complex. [less ▲]

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See detailDynamic Jahn-Teller interaction with Gamma(5) phonons in the ground state of Cu2+ in cubic II-VI semiconductors
Colignon, David ULg; Mailleux, Éric; Kartheuser, Eduard ULg et al

in Physical Review. B : Condensed Matter (1998), 57(20), 12932-12938

Optical absorption and emission measurements of Cu2+ as a substitutional impurity in cubic ZnS and ZnTe rue analyzed by means of an electron-phonon coupling model. The D-2 term of Cu2+ is split by a ... [more ▼]

Optical absorption and emission measurements of Cu2+ as a substitutional impurity in cubic ZnS and ZnTe rue analyzed by means of an electron-phonon coupling model. The D-2 term of Cu2+ is split by a crystal field of tetrahedral symmetry into a (2) Gamma(5) orbital triplet and a (2) Gamma(3) orbital doublet. Optical transitions have been observed between these two multiplets in ZnS:Cu2+ and within the (2) Gamma(5) ground state in ZnTe:Cu2+. The theoretical model is based on crystal-field theory and includes the spin-orbit interaction and a dynamic Jahn-Teller interaction between the electronic (2) Gamma(5) states and a transverse acoustic phonon of TI symmetry. Starting from the ten spin-orbit wave functions appropriate to the orbital tripler and doubler manifolds, the symmetry-adapted vibronic basis is constructed and used to diagonalize the Hamiltonian matrix. Phonon overtones up to n = 14 are included to ensure convergence of the energy eigenvalues. The measured positions and relative intensities of the spectral lines are described with good accuracy by the theoretical model, including covalency effects.. In ZnS, comparison between theory and experiment yields the following values of the physical parameters: the crystal-field splitting Delta = 5990.6 cm(-1), the spin-orbit coupling constants lambda(1) = -667 cm(-1) and lambda(2) = -830 cm(-1), the phonon energy h omega = 73.5 cm(-1), and the Jahn-Teller stabilization energy E-JT = 474.5 cm(-1) The corresponding parameters in ZnTe are Delta = 6000 cm(-1), lambda(1) = -888 cm(-1), lambda(2)= -830 cm(-1), h omega= 38.8 cm(-1), and E-JT= 468.5 cm(-1). [less ▲]

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See detailearly surfactant changes afetr surfactant therapy in premature infants assisted by HFOV
Battisti, Oreste ULg

in Pediatric Research (1998), 2

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See detailHigh-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635.
Le Bars, Didier; Lemaire, Christian ULg; Ginovart, N. et al

in Nuclear Medicine & Biology (1998), 25(4), 343-50

No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the ... [more ▼]

No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the presence of Kryptofix 222 and K2CO3 by microwave heating (3 min, 500 W) using a remotely controlled radiosynthesis. Baseline separation of p-[18F]MPPF from the nitro derivative was performed on a semipreparative HPLC C18 column. After Sep-Pak formulation, the radiopharmaceutical was obtained with a radiochemical yield of 25% (EOS) in about 70 min. Specific radioactivity averaged between 1-5 Ci/micromol EOS. Labelling of the ortho and meta derivatives was also attempted. Brain uptake of p-[18F]MPPF was studied with PET on fluothane-anesthetized cats. Following intravenous injection of p-[18F]MPPF, high accumulation of radioactivity was observed in the hippocampus and cerebral cortex. Low levels of radioactivity were observed in cerebellum. At 30 min, the mean hippocampus/cerebellum and cortex/cerebellum ratios were 5 and 3.8, respectively. The accumulation of the tracer was blocked by prior administration of reference WAY-100635, demonstrating the specificity of the ligand. [less ▲]

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See detailVertical column abundances of COF2 above the Jungfraujoch Station, derived from ground-based infrared solar observations
Mélen, F.; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

in Journal of Atmospheric Chemistry (1998), 29(2), 119-134

Total vertical column abundances of carbonyl fluoride (COF2) have been derived from observations made at the International Scientific Station of the Jungfraujoch (ISSJ; altitude 3.58 km, latitude 46.5 ... [more ▼]

Total vertical column abundances of carbonyl fluoride (COF2) have been derived from observations made at the International Scientific Station of the Jungfraujoch (ISSJ; altitude 3.58 km, latitude 46.5 degrees N, longitude 8.0 degrees E), Switzerland. A systematic analysis of two microwindows containing lines of the vi band was performed, based on a large set of high resolution infrared solar absorption spectra recorded with Fourier transform spectrometers, from 1985 to 1995. Examination of the whole available database indicates a significant increase of the burden of COF2 during the 1988-1995 period. The average exponential rate and the average linear rate referenced to 1992, calculated from daily mean measurements, are both equal to (4.0 +/- 0.5)% yr(-1) (one sigma error). The results are also evaluated and discussed within the context of seasonal variability and correlation between carbonyl fluoride and hydrogen fluoride (HF) columns above the ISSJ. [less ▲]

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See detailIncidence of Inflammatory Bowel Disease in the Area of Liege: A 3 Years Prospective Study (1993-1996)
Latour, Pascale ULg; Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1998), 61(4, Oct-Dec), 410-3

A first prospective epidemiological study of IBD was conducted in the area of Liege. The duration of the study was short taking into account the small size of the population (1 million inhabitants ... [more ▼]

A first prospective epidemiological study of IBD was conducted in the area of Liege. The duration of the study was short taking into account the small size of the population (1 million inhabitants). Therefore we carried out a 3 years prospective study. METHOD: Private and public gastroenterologists completed a questionnaire for each new case they diagnosed between 01.06.1993 and 31.05.1996. RESULTS: During that period 270 IBD patients were identified: 137 (51%) had Crohn's disease (CD), 111 (41%) had ulcerative colitis (UC) including 32 proctitis (29% of UC) and 22 (8%) had unclassified colitis. The mean annual incidence per 10(5) was 4.5 for CD and 3.6 for UC. The female/male ratio was 1,6 for CD and 0,5 for UC. The median age at the time of diagnosis was 30 years for CD and 39 years for UC. The mean time between the onset of symptoms and the diagnosis was 6,5 months for CD and only 4,8 months for UC. Family history of IBD was found in 15% of patients with CD and in 7% of UC. CONCLUSIONS: These data show a high incidence of IBD in the area of Liege. These results confirm those reported during the first year of the prospective study which were similar to those observed in North-western France. Contrary to the other countries of Northern Europe, the incidence of UC is lower than the one of CD. Belgium appears to be a privileged country to undertake a national register and to study epidemiological aspects of IBD. [less ▲]

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See detailCompétence vectorielle des lignées Bobo Dioulasso et Maisons-Alfort de Glossina palpalis gambiensis Vanderplank 1949 infectées simultanément par Trypanosoma brucei brucei EATRO 1125
Kazadi, J. M.; Kagéruka, P.; Losson, Bertrand ULg et al

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (1998), 51

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See detailL'échangeur, exercice structuré en dynamique des groupes
Faulx, Daniel ULg

in Cahiers Internationaux de Psychologie Sociale (1998), 3

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See detailInteractions entre le vecteur et le trypanosome dans la détermination de la compétence vectorielle des glossines
Kazadi, J. M.; Geerts, S.; Kagéruka, P. et al

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (1998), 51

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See detailNéoplasie mammaire plurifocale en généralisation osseuse
Blocklet, Didier; Seret, Alain ULg; Schoutens, André

in Revue Médicale de Bruxelles (1998), 19

Clinical case.

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See detailPostmortem Investigations on Winter Stranded Sperm Whales from the Coasts of Belgium and the Netherlands
Jauniaux, Thierry ULg; Brosens, L.; Jacquinet, E. et al

in Journal of Wildlife Diseases (1998), 34(1), 99-109

During winter 1994-95, four and three sperm whales (Physeter macrocephalus) were stranded along the Belgian and the Dutch coasts, respectively. Necropsies and tissue samplings were collected 24 hrs post ... [more ▼]

During winter 1994-95, four and three sperm whales (Physeter macrocephalus) were stranded along the Belgian and the Dutch coasts, respectively. Necropsies and tissue samplings were collected 24 hrs post mortem. Lesions on several whales included round and linear skin scars, ventral skin abrasions, acute skin ulcers, acute ulcerative stomatitides, acute to chronic external otitides, and passive visceral congestion. In addition, these sperm whales appeared to be debilitated with severe weight deficit, had blubber thickness reduction, the absence of abdominal fat, and the intestinal tracts were almost empty. Three categories of lesions and their possible relation with the stranding were evaluated. Cutaneous scars observed on the seven whales appeared to have no relation with the stranding. The poor body condition and acute integument ulcerative lesions were present before the stranding. Ventral skin abrasions and visceral passive congestion were caused by the strandings. Absence of food in the alimentary tracts, evidence of weight loss and blubber thickness reduction were compatible with an extended presence of the sperm whales in the North Sea, where adequate food is not available. This might lead to progressive weakness, predisposing the animals to secondary pathogens such as viral diseases. Finally, the coastal configuration of the southern North Sea makes it a trap for sperm whales which have entered the area during their wanderings. [less ▲]

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See detailA Novel Bacteriocin With A Ygngv Motif From Vegetable-Associated Enterococcus Mundtii: Full Characterization And Interaction With Target Organisms
Bennik, Mhj.; Vanloo, B.; Brasseur, Robert ULg et al

in Biochimica et Biophysica Acta-Biomembranes (1998), 1373(1), 47-58

A novel broad-spectrum antimicrobial peptide produced by vegetable-associated Enterococcus mundtii was purified and characterized, and designated mundticin. To our knowledge, this is the first report on ... [more ▼]

A novel broad-spectrum antimicrobial peptide produced by vegetable-associated Enterococcus mundtii was purified and characterized, and designated mundticin. To our knowledge, this is the first report on bacteriocin production by this organism. The elucidation of the full primary amino acid sequence of mundticin (KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWSK) revealed that this antimicrobial peptide belongs to the class IIa bacteriocins of lactic acid bacteria which share a highly conserved N-terminal 'YGNGV' motif. Data obtained by computer modelling indicated an oblique orientation of the alpha-helical regions of mundticin and homologous class IIa bacteriocins at a hydrophobic-hydrophilic interface, which may play a role in the destabilization of phospholipid bilayers. The average mass of mundticin, as determined by electron spray mass spectrometry, was found to be 4287.21+/-0.59 Da. With respect to its biological activity, mundticin was shown to inhibit the growth of Listeria monocytogenes, Clostridium botulinum and a variety of lactic acid bacteria. Moreover, it was demonstrated to have a bactericidal effect on L. monocytogenes as a result of the dissipation of the membrane potential, and a loss of intracellular ATP in absence of ATP leakage. Its good solubility in water, and its stability over a wide pH and temperature range indicate the potential of this broad spectrum bacteriocin as a natural preservation agent for foods. [less ▲]

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See detailAn association exists between bovine herpesvirus-4 seropositivity and abortion in cows.
Czaplicki, G.; Thiry, Etienne ULg

in Preventive Veterinary Medicine (1998), 33(1-4), 235-40

The prevalence of cattle seropositive to bovine herpesvirus-4 (BHV-4) is high in Belgium. In Belgian farms, clinical signs associated with BHV-4 infection essentially involve the genital tract and consist ... [more ▼]

The prevalence of cattle seropositive to bovine herpesvirus-4 (BHV-4) is high in Belgium. In Belgian farms, clinical signs associated with BHV-4 infection essentially involve the genital tract and consist mainly of postpartum metritis or metroperitonitis. The role of BHV-4 in abortion has not been definitively demonstrated but epidemiological and experimental facts suggest its involvement. A seroepidemiological investigation was therefore conducted as a case-control study to compare the seroprevalences of BHV-4 infections in the aborted-cow population and in a randomly selected control group in the province of Liege (Belgium). The seroprevalence (17.2%) in aborted cows was significantly higher than that of the control group (10.0%). The odds ratio (OR) was 1.87 (1.06 < 3.30). BHV-4 infection is therefore considered as a risk factor for abortion in cows. [less ▲]

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See detailL'enseignement en sciences commerciales: les valeurs liées à la relation pédagogique
Robert, Jocelyne ULg

in Education-Formation (1998), 254(Printemps), 15-24

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See detailGrowth hormone binding protein (GHBP) during lactation in cows
Renaville, Robert ULg; Prandi, Alberto; Massart, Serge et al

in Archivio Veterinario Italiano (1998), 48

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See detailUrbanisation et consommation d’espace en Belgique. Tendances régionales récentes
Merenne-Schoumaker, Bernadette ULg; Jehin, Jean-Baptiste

in Acta Geographica Lovaniensia (1998), (37), 171-184

The object of this article is to measure the recent evolution of the urban space in Belgium, to show the regional diversity of the process and to seek its main mechanisms. It is based on the cadastral on ... [more ▼]

The object of this article is to measure the recent evolution of the urban space in Belgium, to show the regional diversity of the process and to seek its main mechanisms. It is based on the cadastral on a communal scale. As one could reasonably expect, the Belgian urban space has progressed since 1980, yet at a slower rhythm than during the years 1959-1970. Housing is its main component with over a half of the entire land-use. What growth rate concerns, services (and especially offices) are in the second place while industry ranks to the third position. Regional contrasts generally sharpened. Considering that urbanisation reflects the regional or local dynamism very distinctly, higher values spread out not only in places of suburbanisation and rurbanisation, but also in the developing regions. [less ▲]

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See detailCalretinin expression as a critical component in the control of dentate gyrus long-term potentiation in mice
Gurden, H.; Schiffmann, S. N.; Lemaire, M. et al

in European Journal of Neuroscience (1998), 10

We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc ... [more ▼]

We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415 ). Here, we investigated dentate LTP induction in mice heterozygous (Cr+/–) for the same mutation. Despite the presence of calretinin in neurons of these mice, although at reduced levels as compared with normal mice, LTP induction in dentate gyrus was totally impaired. Spatial memory and learning were found unaffected in Cr+/– mice, such as in Cr–/– mice. Altogether, our results suggest that calretinin is a critical component in the control of dentate synaptic plasticity in mice, and that levels of calretinin higher than those observed in Cr+/– mice are required to induce LTP in this area. The possible mechanisms leading to the absence of correlation between gene dosage and biological effects are discussed [less ▲]

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See detailGamma-aminobutyric acid-sub(A) agonists differentially gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice
Tirelli, Ezio ULg; Geter-Douglass, B.; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1998), 284(1), 116-124

Evaluated the interaction of either gaboxadol HCl (THIP) or muscimol, both gamma-aminobutyric acid (GABA) type A agonists, with indirect-acting dopamine agonists (DAGs) methylphenidate, (+)-amphetamine ... [more ▼]

Evaluated the interaction of either gaboxadol HCl (THIP) or muscimol, both gamma-aminobutyric acid (GABA) type A agonists, with indirect-acting dopamine agonists (DAGs) methylphenidate, (+)-amphetamine, metamphetamine, amfonelic acid, indatraline, nomifensine, diclofensine, mazindol, and GBR 12935 and with direct-acting DAGs WIN 35,428, bupropion, GBR 12909, and cocaine. 1,832 male C57BL/6J mice were given either with saline or 1 of the doses of THIP or muscimol before an injection of a dopamine agonist. Gnawing on corrugated packing paper was measured. Results showed that: (1) indirect- but not direct-acting DAGs induced gnawing, (2) gnawing induced by indirect-acting DAGs GBR 12935, nomifensine and mazindol was potentiated in mice in which GABA type A receptors were stimulated either by THIP or muscimol, and (3) indirect DAGs had a differential sensitivity to the effects of THIP and muscimol. ((c) 1998 APA/PsycINFO, all rights reserved) [less ▲]

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See detailHydrolysis Of The Dimethyl Ester Of N-Succinylphenylalanine, A Model Of Polyesteramides, In The Presence Of Papain - Kinetic Study And Computer Simulation
David, C.; Lefèbvre, F.; Brasseur, Robert ULg et al

in Enzymes In Polymer Synthesis (1998), 684

Our work is concerned with the kinetics of enzymatic hydrolysis of substrates containing ester and amide groups and with the interactions between the active site of the enzyme and the function to be ... [more ▼]

Our work is concerned with the kinetics of enzymatic hydrolysis of substrates containing ester and amide groups and with the interactions between the active site of the enzyme and the function to be hydrolyzed, special attention is paid to differences between a soluble substrate which can fit the active site and a crystalline or semi-crystalline substrate. [less ▲]

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See detailEffect Of Drying On Bioremediation Bacteria Properties
Weekers, F.; Jacques, P.; Springael, D. et al

in Applied Biochemistry and Biotechnology (1998), 70-2

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See detailConnectionism and the problem of multiple instantiation
Sougné, Jacques ULg

in Trends in Cognitive Sciences (1998), 2(5), 183-189

Multiple instantiation is the ability to handle different instances of the same concept simultaneously. For example, from the following two facts: 'Pepin the Short was the son of Charles Martel' and ... [more ▼]

Multiple instantiation is the ability to handle different instances of the same concept simultaneously. For example, from the following two facts: 'Pepin the Short was the son of Charles Martel' and 'Charlemagne was the son of Pepin the Short', one can infer that Charles Martel was the grandfather of Charlemagne. This inference requires two instantiations of 'Pepin the Short', the first in the role of son, the second in the role of father. For a connectionist model that does not use a working area receiving copies of items from a long-term knowledge base, the problem of multiple instantiation is a particularly thorny one. People are able to deal with multiple instances, unlike most connectionist models, but nonetheless their performance when doing so is reduced. On the other hand, there is no decrease in performance for symbolic models doing multiple instantiation. A good cognitive model should reflect both human competence and human limitations. This review proposes several connectionist solutions to the problem of multiple instantiation and examines their merits. [less ▲]

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See detailEvaluation Of The Genetic Variability Of 23 Bovine Microsatellite Markers In Four Belgian Cattle Breeds
Peelman, Lj.; Mortiaux, F.; Van Zeveren, A. et al

in Animal Genetics (1998), 29(3),

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See detailLes principales plantes toxiques chez le cheval
Delaunois, A.; Demoulin, V.; Gustin, Pascal ULg

in Annales de Médecine Vétérinaire (1998), 142

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See detailReaction of N-benzylideneanilines with methyl 3-aminocrotonate catalyzed by inorganic solids
Balogh, Maria; Delaude, Lionel ULg; Hermecz, Istvan

in Heterocyclic Communications (1998), 4(5), 403-410

N-benzylideneanilines 1 react with methyl 3-aminocrotonate 2 in the presence of solid acidic catalysts (K10 montmorillonite or ZF520 zeolite) to give dimethyl 4-(substituted)phenyl-2,6dimethyl-1,4 ... [more ▼]

N-benzylideneanilines 1 react with methyl 3-aminocrotonate 2 in the presence of solid acidic catalysts (K10 montmorillonite or ZF520 zeolite) to give dimethyl 4-(substituted)phenyl-2,6dimethyl-1,4-dihydropyridine-3,5-dicarboxylates 3 as major products. Methyl 2-(methoxycarbonylmethylene)-6-methyl-4-(substituted)phenyl-1,2,3,4-tetr ahydro-5-pyridinecarboxylates 4 and methyl 4-(methoxycarbonylmethyl)-2-methyl-6- (substituted)phenyl-3-pyridinecarboxylates 5 were isolated as minor products. [less ▲]

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See detailEnantioseparation of Acidic Drugs by Capillary Electrophoresis Using Dual Systems with Mixtures of Charged and Neutral Cyclodextrins
Fillet, Marianne ULg; Fotsing, Lucas ULg; Schomburg, G. et al

in Biomedical Chromatography : BMC (1998), 12(3, May-Jun), 131-2

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See detailBonding electropolymerization: a new electron-transfer strategy for the tailoring of performant polymer-based composites
Baute, Noëlle; Calberg, Cédric ULg; Dubois, Philippe ULg et al

in Macromolecular Symposia (1998), 134

Careful control of experimental conditions in the cathodic electropolymerization of acrylonitrile allows the grafting of thin polymer films, on conducting surfaces offering electrons easily mobilized at a ... [more ▼]

Careful control of experimental conditions in the cathodic electropolymerization of acrylonitrile allows the grafting of thin polymer films, on conducting surfaces offering electrons easily mobilized at a relatively low potential. Matching relative polarity and donicity of solvent and monomer expands the applicability of this methodology to the whole class of (meth)acrylic monomers, paving the way to many new and useful multiphase materials. [less ▲]

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See detailEffects of Target-Controlled Anesthesia with Propofol and Sufentanil on the Hemodynamic Response to Mayfield Head Holder Application
Hans, Pol ULg; Coussaert, E.; Cantraine, F. et al

in Acta Anaesthesiologica Belgica (1998), 49(1), 7-11

The effects of target-controlled anesthesia with propofol and sufentanil on the hemodynamic response to Mayfield head holder (MH) application were evaluated in 18 ASA I and II patients undergoing ... [more ▼]

The effects of target-controlled anesthesia with propofol and sufentanil on the hemodynamic response to Mayfield head holder (MH) application were evaluated in 18 ASA I and II patients undergoing scheduled intracranial surgery. Premedication consisted of hydroxyzine, alprazolam and atropine given orally 1 h before surgery. Anesthesia was provided with propofol and sufentanil using a target-controlled infusion device; constant calculated plasma concentrations of 4 micrograms ml-1 propofol and 0.5 ng ml-1 sufentanil were maintained throughout the study. Muscle relaxation was obtained with atracurium and ventilation was controlled with air/oxygen. The MH was fixed 45 +/- 12 min (mean +/- SD) after induction of anesthesia. Heart rate and systolic, diastolic, and mean non invasive arterial pressure were monitored and recorded 5 min before induction of anesthesia (control), 1 min before MH application (MH-1), at MH application, and 1 and 2 min after MH application. Systolic, diastolic, mean arterial pressure, and heart rate increased significantly during and after MH application when compared with MH-1 values, but remained constantly lower than control. Hemodynamic parameters measured 1 min before MH application were significantly lower than control. The results of the study indicate that target-controlled anesthesia maintained with constant calculated plasma concentrations of 4 micrograms ml-1 propofol and 0.5 ng ml-1 sufentanil prevents the increase in arterial pressure and heart rate beyond control values following MH application but may induce some degree of arterial hypotension in the absence of nociceptive stimulation. [less ▲]

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See detailL'arbre que cache la forêt
Duchesne, Jean-Patrick ULg

in Art&fact (1998), 17

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See detailInduction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury.
Hopkins, D. A.; Plumier, Jean-Christophe ULg; Currie, R. W.

in Experimental Neurology (1998), 153(2), 173-83

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular ... [more ▼]

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular metabolic stress. In this study, we examined the distribution of Hsp27 in the rat medulla oblongata by means of immunohistochemistry after the vagus nerve was cut or crushed. After vagal injury, rats were allowed to survive for 6, 12, 24 h, 2, 4, 7, 10, 14, 30, or 90 days. Vagus nerve lesions resulted in a time-dependent up-regulation of Hsp27 in vagal motor and nodose ganglion sensory neurons that expressed Hsp27 constitutively and de novo induction in neurons that did not express Hsp27 constitutively. In the dorsal motor nucleus of the vagus nerve (DMV) and nucleus ambiguus, the levels of Hsp27 in motor neurons were elevated within 24 h of injury and persisted for up to 90 days. Vagal afferents to the nucleus of the tractus solitarius (NTS) and area postrema showed increases in Hsp27 levels within 4 days that were still present 90 days postinjury. In addition, increases in Hsp27 staining of axons in the NTS and DMV suggest that vagus nerve injury resulted in sprouting of afferent axons and spread into areas of the dorsal vagal complex not normally innervated by the vagus. Our observations are consistent with the possibility that Hsp27 plays a role in long-term survival of distinct subpopulations of injured vagal motor and sensory neurons. [less ▲]

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See detailPharma clinics. Comment je traite ... un patient diabetique avec obesite severe.
Scheen, André ULg; Triches, K.; Luyckx, Françoise ULg et al

in Revue Médicale de Liège (1998), 53(7), 386-9

Obesity plays a crucial role in type 2 diabetes pathophysiology and a major weight loss markedly improves glycaemic control. The common failure of classical treatments leads to the use of more aggressive ... [more ▼]

Obesity plays a crucial role in type 2 diabetes pathophysiology and a major weight loss markedly improves glycaemic control. The common failure of classical treatments leads to the use of more aggressive weight-reduction approaches, such as very-low-calorie diets (VLCDs), anti-obesity drugs or even bariatric surgery. VLCDs are very successful in the short-term but rather disappointing in the long-term. Anti-obesity compounds only induce a modest mean weight reduction, even if some patients appear to be better responders. Interestingly, serotoninergic agents increase insulin sensitivity and glycaemic control, independently of weight loss. Bariatric surgery provides the most impressive results. In well-selected subjects, gastroplasty (either vertical ring gastroplasty or adjustable silicone gastric banding) generally induces a considerable weight loss which results in a remarkable and sustained glycaemic control improvement and allows the reduction, or even the suppression, of any antidiabetic treatment. This ultimate solution should not be neglected after failure of medical approaches, provided that the indication is correct, the surgical procedure is performed in a specialized centre and the followup is well organized by a multidisciplinary team. [less ▲]

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See detailComparative Evaluation of Cerebral Aneurysms with Selective Arterially Enhanced Ct and Dsa
Vanderschelden, P.; Flandroy, P.; Dondelinger, R. F. et al

in European Radiology (1998), 8(7), 1181-6

The purpose of our study was to compare selective arterially enhanced spiral computed tomographs (ACT) with digital subtraction angiographies (DSA) in the presurgical assessment of cerebral aneurysms. A ... [more ▼]

The purpose of our study was to compare selective arterially enhanced spiral computed tomographs (ACT) with digital subtraction angiographies (DSA) in the presurgical assessment of cerebral aneurysms. A total of 24 aneurysms in 18 patients were explored in a prospective study by ACT and DSA, using an interactive combined CT-angiography suite. Dimensions of the aneurysm, its relation to the parent vessel, and the aneurysmal index were defined on DSA and on surface-shaded display of 3D reformatted images obtained from ACT. Results were correlated with surgical findings. Three aneurysms suspected on DSA were not confirmed by ACT. One fusiform aneurysm suspected on DSA corresponded to a sacciform aneurysm on ACT. Surgical findings confirmed 20 sacciform aneurysms. The aneurysmal index could be measured in all 20 cases of sacciform aneurysms on ACT and could not be determined with confidence in 55 % of the cases on DSA. DSA and ACT gave identical results in 35 % of cases. In 10 %, the index measured by ACT was superior to that determined by DSA for aneurysms which had a diameter of less than 3 mm. In conclusion, the combination of DSA and ACT improved the results of DSA alone. ACT is a reliable method to measure the aneurysmal index in aneurysms with a diameter superior to 3 mm. [less ▲]

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See detailActualites therapeutiques 1997-1998 (1). Premiere partie.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(8), 459-66

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be stressed. This first part is devoted to drugs acting on cardiovascular, respiratory, digestive and neurologic diseases. [less ▲]

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See detailCell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice.
GOTHOT, André ULg; Van der loo, J. C. M.; Clapp, D. W. et al

in Blood (1998), 92(8), 2641-9

Most primitive hematopoietic progenitor cells reside in vivo within the G0/G1 phase of the cell cycle. By simultaneous DNA/RNA staining it is possible to distinguish G0 and G1 states and to isolate cells ... [more ▼]

Most primitive hematopoietic progenitor cells reside in vivo within the G0/G1 phase of the cell cycle. By simultaneous DNA/RNA staining it is possible to distinguish G0 and G1 states and to isolate cells in defined phases of the cell cycle. We report here the use of cell cycle fractionation to separate human mobilized peripheral blood (MPB) CD34(+) cells capable of repopulating the bone marrow (BM) of non-obese diabetic/severe combined immune-deficient (NOD/SCID) mice. In freshly isolated MPB, repopulating cells were predominant within the G0 phase, because transplantation of CD34(+) cells residing in G0 (G0CD34(+)) resulted on average in a 16.6- +/- 3.2-fold higher BM chimerism than infusion of equal numbers of CD34(+) cells isolated in G1. We then investigated the effect of ex vivo cell cycle progression, in the absence of cell division, on engraftment capacity. Freshly isolated G0CD34(+) cells were activated by interleukin-3 (IL-3), stem cell factor (SCF), and flt3-ligand (FL) for a 36-hour incubation period during which a fraction of cells progressed from G0 into G1 but did not complete a cell cycle. The repopulating capacity of stimulated cells was markedly diminished compared with that of unmanipulated G0CD34(+) cells. Cells that remained in G0 during the 36-hour incubation period and those that traversed into G1 were sorted and assayed separately in NOD/SCID recipients. The repopulating ability of cells remaining in G0 was insignificantly reduced compared with that of unstimulated G0CD34(+) cells. On the contrary, CD34(+) cells traversing from G0 into G1 were largely depleted of repopulating capacity. Similar results were obtained when G0CD34(+) cells were activated by the combination of thrombopoietin-SCF-FL. These studies provide direct evidence of the quiescent nature of cells capable of repopulating the BM of NOD/SCID mice. Furthermore, these data also demonstrate that G0-G1 progression in vitro is associated with a decrease in engraftment capacity. [less ▲]

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See detailPurification of myeloperoxidase from equine polymorphonuclear leucocytes.
Mathy, Marianne ULg; Bourgeois, E.; Grulke, Sigrid ULg et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1998), 62(2), 127-32

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute ... [more ▼]

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute inflammation). To develop an assay for measurement of plasma MPO in horses during the above-mentioned infectious and inflammatory conditions, MPO was purified from equine PMN isolated from blood anticoagulated with citrate. PMN were extracted in a saline milieu (0.2 M Na acetate, 1 M NaCl, pH 4.7) to eliminate most of cellular proteins. Pellets were then extracted in the same buffer containing cationic detergent (1% cetyltrimethyl ammonium bromide). The supernatant was further purified by ion exchange chromatography (Hiload S Sepharose HP column 0.5 x 26 cm, equilibrated with 25 mM Na acetate, 0.2 M NaCl, pH 4.7) with a NaCl gradient (until 1 M). Most of the peroxidase activity of MPO (spectrophotometrically measured by the oxidation of orthodianisidine by hydrogen peroxide) was eluted at 0.65 M NaCl. MPO was further purified by gel filtration chromatography (Sephacryl S 200 column 2.6 x 42 cm with 25 mM Na acetate, 0.2 M NaCl, pH 4.7). MPO (specific activity: 74.3 U/mg) was obtained with a yield of 30% from the detergent extraction supernatant. Electrophoresis (non-reducing conditions) showed 3 bands identified, by comparison with human MPO, (i) the mature tetrameric enzyme (150 kDa) with 2 light and 2 heavy subunits, (ii) the precursor form (88 kDa) and (iii) a form of the heavy subunit without the prosthetic heme group (40 kDa). The mature enzyme and its precursor were glycosylated and possessed peroxidase activity. Equine MPO showed strong similarities with human and bovine MPO, with an absorption peak at 430 nm (Soret peak) characteristic of ferrimyeloperoxidase. Enzymatic activity was pH dependent (optimal value at pH 5.5). [less ▲]

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See detailScale relativity and quantization of the solar system - Orbit quantization of the planet's satellites
Hermann, Raphaël ULg; Schumacher, G.; Guyard, R.

in Astronomy and Astrophysics (1998), 335(1), 281-286

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present ... [more ▼]

In a first paper Nottale, Schumacher and Gay have given the bases of the Scale Relativity theory applied to the gravitational field, which leads to the quantization of the solar system. In the present paper we show that one more class of objects of the solar system satisfy the rule of quantization, this class including the main satellites and rings of the outer planets. We also give a classification of the satellites by rank, showing that one can predict the existence of certain orbits that are not occupied, or whose objects are not yet discovered. [less ▲]

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See detailLe cas clinique du mois. Une nephropathie galopante chez un patient diabetique de type 2.
Philips, Jean-Christophe ULg; Scheen, André ULg; Firre, E. et al

in Revue Médicale de Liège (1998), 53(4), 171-4

We report the case of a patient with insulin-requiring type 2 diabetes who exhibited a rapid deterioration of his renal function leading to haemodialysis in a few months. Various diagnosis were considered ... [more ▼]

We report the case of a patient with insulin-requiring type 2 diabetes who exhibited a rapid deterioration of his renal function leading to haemodialysis in a few months. Various diagnosis were considered to explain this rapid deterioration, excluding diabetic nephropathy as major etiology. The exploration, especially renal biopsy, demonstrated the presence of a glomerulonephritis due to the deposition of immune complexes associated to active hepatitis C rather than diabetic glomerulosclerosis. A treatment with interferon-alpha allowed to partially restore renal function, this recovery permitting the interruption of hemodialysis, with a current follow-up of more than 6 months. [less ▲]

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See detailLa résistance bactérienne aux antibiotiques, un modèle exemplaire d'évolution moléculaire dirigée.
Ghuysen, Jean-Marie ULg

in Revue Médicale de Liège (1998), 53(9), 529-531

The simplest conceivable event that can occur at the gene level can result in the development of efficacious resistance tot antibiotics. The bacterial world behaves as an enormous organism whose cells can ... [more ▼]

The simplest conceivable event that can occur at the gene level can result in the development of efficacious resistance tot antibiotics. The bacterial world behaves as an enormous organism whose cells can exchange their genes very easily. Accordingly, oppotunities for the exhcange of genetic material in nature are probably unlimited. This knowledge cannot be ignored. It leads to the important conclusion that the antibiotics are societal drugs. A resistance gene which has appeared somewhere in the world can travel far and fast. [less ▲]

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See detailHematopoietic recovery in cancer patients after transplantation of autologous peripheral blood CD34+ cells or unmanipulated peripheral blood stem and progenitor cells.
Beguin, Yves ULg; Baudoux, Etienne ULg; Sautois, Brieuc ULg et al

in Transfusion (1998), 38(2), 199-208

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS ... [more ▼]

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS: Peripheral blood stem and progenitor cells (PBPCs) were collected from 32 patients, and 17 CD34+ cell-selection procedures were carried out in 15 of the 32. One patient in whom two procedures failed to provide 1 x 10(6) CD34+ cells per kg was excluded from further analysis. After conditioning, patients received CD34+ cells (n = 10, CD34 group) or unmanipulated (n = 17, PBPC group) PBPCs containing equivalent amounts of CD34+ cells or progenitors. RESULTS: The yield of CD34+ cells was 53 percent (18-100) with a purity of 63 percent (49-82). The CD34+ fraction contained 66 percent of colony-forming units--granulocyte-macrophage (CFU-GM) and 58 percent of CFU of mixed lineages, but only 33 percent of burst-forming units-erythroid (BFU-E) (p < 0.05). Early recovery of neutrophils and reticulocytes was identical in the two groups, although a slight delay in platelet recovery may be seen with CD34+ cell selection. Late hematopoietic reconstitution, up to 1.5 years after transplant, was also similar. The two groups were thus combined for analyses of dose effects. A dose of 40 x 10(4) CFU-GM per kg ensured recovery of neutrophils to a level of 1 x 10(9) per L within 11 days, 15 x 10(4) CFU of mixed lineages per kg was associated with platelet independence within 11 days, and 100 x 10(4) BFU-E per kg predicted red cell independence within 13 days. However, a continuous effect of cell dose well beyond these thresholds was apparent, at least for neutrophil recovery. CONCLUSION: CD34+ cell selection, despite lower efficiency in collecting BFU-E, provides a suitable graft with hematopoietic capacity comparable to that of unmanipulated PBPCs. In both groups, all patients will eventually show hematopoietic recovery of all three lineages with 1 x 10(6) CD34+ cells per kg or 5 x 10(4) CFU-GM per kg, but a dose of 5 x 10(6) CD34+ cells or 40 x 10(4) CFU-GM per kg is critical to ensure rapid recovery. [less ▲]

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See detailA Qtl with Major Effect on Milk Yield and Composition Maps to Bovine Chromosome 14
Coppieters, Wouter ULg; Riquet, J.; Arranz, J. J. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1998), 9(7), 540-4

A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of ... [more ▼]

A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of a locus on the centromeric end of bovine Chromosome (Chr) 14, with major effect on fat and protein percentage as well as milk yield. The genuine nature of this QTL was verified using the grand2-daughter design, that is, by tracing the segregating QTL alleles from heterozygous grandsires to their maternal grandsons and confirming the predicted QTL allele substitution effect. [less ▲]

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See detailClinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials.
Scheen, André ULg

in Diabètes & Métabolism (1998), 24(4), 311-20

Acarbose, an alpha-glucosidase inhibitor, is a new antihyperglycaemic agent which has been proposed as add-on therapy in Type 2 diabetic patients not well-controlled with diet alone, sulphonylurea ... [more ▼]

Acarbose, an alpha-glucosidase inhibitor, is a new antihyperglycaemic agent which has been proposed as add-on therapy in Type 2 diabetic patients not well-controlled with diet alone, sulphonylurea, metformin or insulin, and in Type 1 diabetic patients with large meal-related plasma glucose excursions. Numerous controlled studies investigating the clinical effects of acarbose in Type 2 diabetes versus either placebo or, more rarely, versus a reference drug (sulphonylurea or metformin) have been published during the last 10 years. All placebo-controlled studies have demonstrated the superiority of acarbose, at a dose of 150-600 mg/day, in decreasing fasting and postprandial glucose levels as well as HbA1c concentrations (mean decrease of 0.7%), whether acarbose was given as first-line therapy in diet-treated diabetic patients or in combination in individuals already receiving a sulphonylurea, metformin or insulin. Only a few controlled studies have compared the effects of acarbose with those of either sulphonylurea or metformin, yielding controversial results. In Type 1 diabetic patients, a small reduction of HbA1c levels was also reported after addition of acarbose to insulin therapy, which in some cases allowed a slight reduction of daily insulin needs. All these favourable biological effects occurred without exposing the patient to hypoglycaemia or weight gain. A few studies have also reported favourable effects on postprandial lipid profile and some other vascular risk factors. However, it is not clear whether the extra cost of acarbose, when compared to that of older oral antidiabetic agents, is justified since no study has yet demonstrated its potential benefit on the complications and long-term prognosis of diabetic patients. [less ▲]

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See detailIntracellular and extracellular vaccinia virions enter cells by different mechanisms
Vanderplasschen, Alain ULg; Hollinshead, M.; Smith, G. L.

in Journal of General Virology (The) (1998), 79(Pt 4), 877-887

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See detailOral antidiabetic agents. A guide to selection.
Scheen, André ULg; Lefebvre, Pierre ULg

in Drugs (1998), 55(2), 225-36

Type 2 diabetes mellitus (formerly named non-insulin-dependent diabetes mellitus or NIDDM) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin ... [more ▼]

Type 2 diabetes mellitus (formerly named non-insulin-dependent diabetes mellitus or NIDDM) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. Various pharmacological approaches can be used to improve glucose homeostasis via different modes of action: sulphonylureas essentially stimulate insulin secretion, biguanides (metformin) act by promoting glucose utilisation and reducing hepatic-glucose production, alpha-glucosidase inhibitors (acarbose) slow down carbohydrate absorption from the gut and thiazolidinediones (troglitazone) enhance cellular insulin action on glucose and lipid metabolism. These pharmacological treatments may be used individually for certain types of patients, or may be combined in a stepwise fashion to provide more ideal glycaemic control for most patients. Selection of oral antihyperglycaemic agents as first-line drug or combined therapy should be based on both the pharmacological properties of the compounds (efficacy and safety, profile) and the clinical characteristics of the patient (stage of disease, bodyweight, etc.). Mildly hyperglycaemic patients should preferably be treated with metformin, acarbose or thiazolidinediones (which are not associated with any hypoglycaemic risk), while more severely hyperglycaemic individuals should receive a sulphonylurea. In moderately hyperglycaemic patients, sulphonylureas should be preferred in nonobese patients while metformin, and probably also thiazolidinediones, should have priority in obese insulin-resistant type 2 diabetic patients. Acarbose is mainly indicated to reduce post-prandial glucose fluctuations and improve glycaemic stability. Each antihyperglycaemic agent may also be combined with insulin therapy to improve glycaemic control and/or reduce the insulin requirement of diabetic patients after secondary failure to oral treatment. Finally, safety should be taken into account in elderly patients and/or those with renal impairment, especially as far as the use of sulphonylureas (higher risk of hypoglycaemia) and metformin (higher risk of lactic acidosis) is concerned. [less ▲]

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See detailPotentiation of dopamine agonists-induced oral stereotypies by GABA-A agonists in mice : differentiation of dopamine uptake inhibitors
Tirelli, Ezio ULg; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1998), 284

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See detailLa chirurgie sous hypnosedation. Une nouvelle approche therapeutique pour l'hyperparathyroidie.
Defechereux, Thierry ULg; Faymonville, Marie ULg; Joris, Jean ULg et al

in Annales de Chirurgie (1998), 52(5), 439-43

The elective unilateral approach, sometimes under local anaesthesia, offers many advantages in terms of less invasive and faster surgical approach compared to the conventional surgery under general ... [more ▼]

The elective unilateral approach, sometimes under local anaesthesia, offers many advantages in terms of less invasive and faster surgical approach compared to the conventional surgery under general anaesthesia. Nevertheless this approach is restricted to patients unsuspected of multiglandular disease, free from thyroid disease and for whom localization studies are contributive. Surgery under hypnosedation offers the same advantages and provides the possibility of not only exploring the four glands but also of performing a partial thyroidectomy if needed. In our experience 21 patients underwent a cervicotomy under hypnosedation for primary hyperparathyroidism (HPT). No conversion to general anaesthesia was needed; mean operative time was 52 +/- 16 min. In 17 cases, HPT was due to a single adenoma, in 3 cases to hyperplasia (among them a MEN-1 case), and in one last case to a double adenoma. The four glands were identified in 85%. With a follow-up running from 4 to 45 months, all patients are cured. Hypnosedation offers the same medical and economic advantages than the unilateral access under local anaesthesia. Moreover indications are not restricted to selected patients. [less ▲]

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See detailMolecular Structure and Surface Order in Monolayers of Alkanethiols Evidenced by HREELS
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Thin Solid Films (1998), 327-329

Structural characteristics and order within n-alkanethiols, a,q-alkanedithiols and a-cycloalkyl-q-alkanethiols monolayers self-assembled on gold have been investigated using high resolution electron ... [more ▼]

Structural characteristics and order within n-alkanethiols, a,q-alkanedithiols and a-cycloalkyl-q-alkanethiols monolayers self-assembled on gold have been investigated using high resolution electron energy loss spectroscopy (HREELS). The coherent domain sizes have been estimated from the angular distribution of the elastic peak as a function of the nature of the alkane chain and of the immersion time in the thiol solutions. These data have revealed many defects in the organization of the monolayers on evaporated gold substrates. It has been shown that the domains are smaller on Au(100) than on Au(111). [less ▲]

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See detailUne préparation multimédias à affronter les conflits professeur-élèves en classe
Leclercq, Dieudonné ULg; Rommes, O.; Georges, François ULg et al

in Education-Formation (1998), 36130

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See detailStructured imagination of novel creatures' faces
Brédart, Serge ULg; Ward, T. B.; Marczewski, P.

in American Journal of Psychology (The) (1998), 111(4), 607-625

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See detailAnemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production.
Corazza, Francis; Beguin, Yves ULg; Bergmann, Pierre et al

in Blood (1998), 92(5), 1793-8

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect ... [more ▼]

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). To further elucidate the pathophysiology of anemia in children with cancer, we measured serum soluble transferrin receptor (sTfR), a quantitative marker of erythropoiesis, and serum EPO at time of diagnosis and during chemotherapy in children suffering from solid tumor or leukemia. We determined serum EPO in 111 children (55 leukemia, 56 solid tumors) at time of diagnosis. In the last 44 patients (23 leukemia and 21 solid tumors), sTfR levels were also measured. Serum EPO together with sTfR levels were also determined in 60 children receiving chemotherapy (29 leukemia, 31 solid tumors). These results were compared with those obtained from appropriate control groups. In all patients, we found a highly significant correlation between the logarithm of EPO (log[EPO]) and the hemoglobin (Hb) level. In all subsets of patients, sTfR levels were inappropriately low for the degree of anemia. Neither leukemic nor solid tumor groups showed a significant inverse relationship between log(sTfR) and the Hb level as would be expected in anemic patients with appropriate marrow response. Thus, in children with cancer, anemia is associated with a decreased total bone marrow erythropoietic activity which, in contrast to what has been reported in anemic cancer adults, is not related to defective EPO production. [less ▲]

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See detailReciprocal regulation of protein tyrosine kinases p56lck and p59fyn, and altered tyrosine phosphorylation in murine AIDS.
Trebak, Mohamed; Lambert, Chantal ULg; Rahmouni, Souad ULg et al

in International Immunology (1998), 10(10), 1473-80

Murine AIDS (MAIDS), caused by a defective murine leukemia virus, is a severe lymphoproliferative disease associated with profound immunodeficiency and increased susceptibility to opportunistic infections ... [more ▼]

Murine AIDS (MAIDS), caused by a defective murine leukemia virus, is a severe lymphoproliferative disease associated with profound immunodeficiency and increased susceptibility to opportunistic infections. Most subsets of lymphocytes, including CD4+ and CD8+ T cells, are refractory to mitogen stimulation. As a first step to examine proximal signal transduction in the infected mice, Western and Northern blot analyses were performed, and showed that p56lck is dramatically decreased at the protein as well as the mRNA level in the lymph nodes (LN). In contrast, p59(fyn) and its mRNA were slightly increased in the LN of the same mice. Similar results were obtained with purified T cells. Interestingly, the thymus of the infected animals did not show any abnormality regarding p56(lck) or p59(fyn). Tyrosine phosphorylation was constitutively increased in the infected mice and was barely amplified by anti-CD3 mAb stimulation. A similar pattern was observed when tyrosine phosphorylation was selectively examined at the level of ZAP-70. Our results suggest that a reciprocal regulation of p56(lck) and p59(fyn) protein tyrosine kinases, previously described in various models of anergy, could also be involved in the pathogenesis of MAIDS. [less ▲]

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See detailSubliem, al te subliem
Spinoy, Erik ULg

in Parmentier (1998), 8(4), 119-125

This articles tries to explain public resistance towards the early work of Dutch poet Hans Faverey, as a consequence of the fact that this work is motivated by a sublime aesthetics.

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See detailVector mesons from tensor couplings in the NJL model
Jaminon, Martine ULg; Ruiz Arriola, Enrique

in Physics Letters B (1998), 443

We propose to describe vector mesons in a pure quark model such as the one of Nambu and Jona-Lasinio by means of four point tensor interactions, but with vanishing vector and axial couplings. This becomes ... [more ▼]

We propose to describe vector mesons in a pure quark model such as the one of Nambu and Jona-Lasinio by means of four point tensor interactions, but with vanishing vector and axial couplings. This becomes possible due to tensor-vector mixing at the one quark loop level. As a consequence a bound particle with rho quantum numbers is generated. This has the advantage of avoiding the A-pi mixing which is known to generate a wrong off-shell pion wave function renormalization. In addition, there is no A1 meson. We make our arguments quantitative by computing Euclidean correlators via dispersion relations and comparing with lattice QCD and random instanton model results. [less ▲]

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See detailMolecular Definition of an Allelic Series of Mutations Disrupting the Myostatin Function and Causing Double-Muscling in Cattle
Grobet, Luc ULg; Poncelet, D.; Royo, L. J. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1998), 9(3), 210-3

We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be ... [more ▼]

We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous or compound heterozygotes for one of the five loss-of-function mutations. The absence of obvious loss-of-function mutations in the coding sequence of the two remaining breeds points either towards additional mutations in unexplored segments of the gene, or towards locus heterogeneity of double-muscling. [less ▲]

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See detailPhysiopathologie et pathogenèse des douleurs zostériennes
Rentier, Bernard ULg

in Médecine et Maladies Infectieuses (1998), 28(Sp. Iss), 848-850

The origin of post-zosterian pain appears to be multiple. It implies: neuronal lesions in the central and peripheral nervous system. Young patients are less often affected than older individuals, perhaps ... [more ▼]

The origin of post-zosterian pain appears to be multiple. It implies: neuronal lesions in the central and peripheral nervous system. Young patients are less often affected than older individuals, perhaps because of damages that are caused or not to central afferences. Pain could be due to a central hyperexcitability induced and maintained by nociceptors. Antagonists of the NMDA receptor could thus prove efficient against installation of the chronic pain by interfering with neuronal discharges of the peripheral nociceptors and the induction of a hyperexcitability. [less ▲]

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See detailLes enjeux des revendications en matière de moeurs
Jacobs, Ann ULg

in Journal des procès (1998), (345), 22

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See detailThe effect of BaZrO3 addition on transport properties of Dy-based 123-211 composite materials: electrical resistivity, thermal conductivity and thermoelectric power
Bougrine, Hassan ULg; Ausloos, Marcel ULg; Pekala, M. et al

in Superconductor Science & Technology (1998), 11(8), 803-809

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power ... [more ▼]

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power have been measured. The electrical resistivity has also been measured in a magnetic field less than 1 T. The data show that BaZrO3 addition has a non-trivial effect: beside mildly reducing the critical temperature of the superconductor, it increases the scattering at small concentration, and effectively reduces weak link features in the electrical property, but increases the thermal conductivity. The field influence on T-c is shown to be T-c(O)- T-c(B) approximate to B-1/2. [less ▲]

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See detailSevere congenital hypopituitarism with low prolactin levels and age-dependent anterior pituitary hypoplasia: a clue to a PIT-1 mutation
Ward, L.; Chavez, M.; Huot, C. et al

in Journal of Pediatrics (1998), 132(6), 1036-8

A 20-month-old boy presented with severe congenital growth hormone, thyrotropin, and prolactin deficiencies resulting from a de novo mutation of the PIT-1 gene. This form of congenital hypopituitarism ... [more ▼]

A 20-month-old boy presented with severe congenital growth hormone, thyrotropin, and prolactin deficiencies resulting from a de novo mutation of the PIT-1 gene. This form of congenital hypopituitarism should be suspected if pituitary anatomy is normal, especially if prolactin levels are low and, in boys, if the external genitalia are normal. Pituitary atrophy appears to be an age-dependent phenomenon in this condition. [less ▲]

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