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See detailResidence time in a semi-enclosed domain from the solution of an adjoint problem
Delhez, Eric ULg; Heemink, Arnold W.; Deleersnijder, Eric

in Estuarine Coastal & Shelf Science (2004), 61(4), 691-702

The residence time measures the time spent by a water parcel or a pollutant in a given water body and is therefore a widely used concept in environmental studies. While many previous studies rely on ... [more ▼]

The residence time measures the time spent by a water parcel or a pollutant in a given water body and is therefore a widely used concept in environmental studies. While many previous studies rely on severe hypotheses (assuming stationarity of the flow and/or neglecting diffusion) to evaluate the residence time, the paper introduces a general method for computing the residence time and/or the mean residence time without such simplifying hypotheses. The method is based on the resolution of an adjoint advection-diffusion problem and is therefore primarily meant to be used with numerical models. The method and its implications are first introduced using a simplified one-dimensional analytical model. The approach is then applied to the diagnostic of the three-dimensional circulation on the Northwest European Continental Shelf. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailSelection de bactéries lactiques probiotiques d'origine animale
Bouzaine, T.; El Mejdoub, Thami ULg; Hamdi, M. et al

in Microbiologie et hygiène alimentaire (2004), 16(46), 24-29

Une collection de bactéries lactiques isolées à partir de la microflore intestinale de poulets de chair a été soumise à plusieurs tests de sélection afin de retenir des souches dites probiotiques. L ... [more ▼]

Une collection de bactéries lactiques isolées à partir de la microflore intestinale de poulets de chair a été soumise à plusieurs tests de sélection afin de retenir des souches dites probiotiques. L'évaluation de leur pouvoir acidifiant a révélé que les souches appartenant aux espèces Lactobacillus rhamnosus produisent environ 0,1 9g/ml d'acide lactique. Les différentes espèces étudiées ont montré une réponse variable à des pH acide, et l'espèce L. rhamnosus présente une capacité de survie même à un pH très bas de l'ordre de 2,0. La résistance au x sels biliaire, est une propriété commune à toutes les souches testées; néanmoins, le taux de croissance dans un milieu additionné de sels biliaires varie d'une espèce à une autre. L'espèce L. rhamnosus possède aussi une activité antimicrobienne remarquable contre des germes pathogènes et non pathogènes. [less ▲]

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See detailDeficit in decoding emotional facial expression in Parkinson's disease
Dujardin, K.; Blairy, Sylvie ULg; Duhem, S. et al

in Neuropsychologia (2004), 42

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See detailCirculez, il n'y a rien à voir ! De la vacuité d'une phénoménologie purement matérielle
Leclercq, Bruno ULg

in Etudes Phénoménologiques (2004), XX(39-40), 123-174

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See detailCarminite et kintoreite de Hourt, Massif de Stavelot, Belgique.
Hatert, Frédéric ULg; Lefèvre, Pierre

in Bulletin de la Société Royale des Sciences de Liège (2004)

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See detailEnfin une statistique macroéconomique des associations
Mertens de Wilmars, Sybille ULg

in Non Marchand : Management, Droit et Finance (2004), (13), 87-89

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See detailAllogeneic hematopoietic cell transplantation as treatment for hematological malignancies: a review.
Baron, Frédéric ULg; Storb, Rainer

in Springer Seminars in Immunopathology (2004), 26(1-2), 71-94

Allogeneic hematopoietic cell transplantation (HCT) was originally developed as a form of rescue from high-dose chemoradiotherapy, which is given both to eradicate malignancy and provide sufficient ... [more ▼]

Allogeneic hematopoietic cell transplantation (HCT) was originally developed as a form of rescue from high-dose chemoradiotherapy, which is given both to eradicate malignancy and provide sufficient immunosuppression for allogeneic engraftment. The first attempts of allogeneic HCT in humans met with little success. However, a better understanding of the complexities of the human leukocyte antigen (HLA) system has allowed selecting compatible sibling donors, and the development of postgrafting immunosuppressive regimens has helped prevent serious graft-versus-host disease, thereby changing the role of allogeneic HCT from a desperate therapeutic maneuver to a curative treatment modality for many patients with malignant hematological diseases. In addition, the establishment of large registries of HLA-typed volunteers has permitted finding suitable unrelated donors for many patients without family donors. Further advances in the immunogenetics of HLA, especially typing by molecular techniques, have improved results after unrelated HCT, which have begun resembling those obtained with HLA-identical sibling grafts, at least in young patients. Important advances have also been made in the prevention and treatment of infectious complications and in other areas of supportive care. Since the late seventies, it has been recognized that allogeneic immunocompetent cells transplanted with the stem cells, or arising from them, mediated therapeutic anti-tumor effects independent of the action of the high-dose therapy, termed graft-versus-tumor (GVT) effects. This has prompted the recent development of non-myeloablative conditioning regimens for allogeneic HCT that have opened the way to include elderly patients and those with comorbid conditions. Remaining challenges include further advances in the prevention and treatment of both severe graft-versus-host disease and infections. Also, progress in adoptive transfer of T cells with relative tumor specificity and disease-targeted therapy with agents such as Imatinib, Rituximab or radiolabeled monoclonal antibodies would make allogeneic HCT even more effective. [less ▲]

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See detailChronique de la 58ème Session de la Société Internationale Fernand de Visscher au Brésil (20-25 Septembre 2004)
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (2004), LI

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See detailStructural basis of protein phosphatase 1 regulation
Terrak, Mohammed ULg; Kerff, Frédéric ULg; Langsetmo, K. et al

in Nature (2004), 429(6993), 780-4

The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes ... [more ▼]

The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. The human genome encodes a far greater number of Ser/Thr protein kinases than of phosphatases. Protein phosphatase 1 (PP1), in particular, is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits. The regulatory subunits are generally unrelated, but most possess the RVxF motif, a canonical PP1-binding sequence. Here we reveal the crystal structure at 2.7 A resolution of the complex between PP1 and a 34-kDa N-terminal domain of the myosin phosphatase targeting subunit MYPT1. MYPT1 is the protein that regulates PP1 function in smooth muscle relaxation. Structural elements amino- and carboxy-terminal to the RVxF motif of MYPT1 are positioned in a way that leads to a pronounced reshaping of the catalytic cleft of PP1, contributing to the increased myosin specificity of this complex. The structure has general implications for the control of PP1 activity by other regulatory subunits. [less ▲]

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See detailEvaluation of OCMIP-2 ocean models' deep circulation with mantle helium-3
Dutay, J. C.; Jean-Baptiste, P.; Campin, J. M. et al

in Journal of Marine Systems (2004), 48(1-4), 15-36

We compare simulations of the injection of mantle helium-3 into the deep ocean from six global coarse resolution models which participated in the Ocean Carbon Model Intercomparison Project (OCMIP). We ... [more ▼]

We compare simulations of the injection of mantle helium-3 into the deep ocean from six global coarse resolution models which participated in the Ocean Carbon Model Intercomparison Project (OCMIP). We also discuss the results of a study carried out with one of the models, which examines the effect of the subgrid-scale mixing parameterization. These sensitivity tests provide useful information to interpret the differences among the OCMIP models and between model simulations and the data. We find that the OCMIP models, which parameterize subgrid-scale mixing using an eddy-induced velocity, tend to underestimate the ventilation of the deep ocean, based on diagnostics with delta(3)He. In these models, this parameterization is implemented with a constant thickness diffusivity coefficient. In future simulations, we recommend using such a parameterization with spatially and temporally varying coefficients in order to moderate its effect on stratification. The performance of the models with regard to the formation of AABW confirms the conclusion from a previous evaluation with CFC-11. Models coupled with a sea-ice model produce a substantial bottom water formation in the Southern Ocean that tends to overestimate AABW ventilation, while models that are not coupled with a sea-ice model systematically underestimate the formation of AABW We also analyze specific features of the deep He-3 distribution (He-3 plumes) that are particularly well depicted in the data and which put severe constraints on the deep circulation. We show that all the models fail to reproduce a correct propagation of these plumes in the deep ocean. The resolution of the models may be too coarse to reproduce the strong and narrow currents in the deep ocean., and the models do not incorporate the geothermal heating that may also contribute to the generation of these currents. We also use the context of OCMIP-2 to explore the potential of mantle helium-3 as a tool to compare and evaluate modeled deep-ocean circulations. Although the source function of mantle helium is known with a rather large uncertainty, we find that the parameterization used for the injection of mantle helium-3 is sufficient to generate realistic results, even in the Atlantic Ocean where a previous pioneering study [J. Geophys. Res. 100 (1995) 3829] claimed this parameterization generates inadequate results. These results are supported by a multi-tracer evaluation performed by considering the simulated distributions of both helium-3 and natural C-14, and comparing the simulated tracer fields with available data. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detail« Myosite » focale de la loge antéro-externe de la jambe : à propos d’un cas
TOMASELLA, Marco ULg; CRIELAARD, Jean-Michel ULg; WANG, François-Charles ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2004)

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See detailLa forêt privée wallonne, sa gestion et ses propriétaires (2e partie)
Colson, Vincent ULg; Puissant, T.; Hebert, Jacques ULg et al

in Silva Belgica (2004), 111(5), 32-38

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See detailThe natural history, including orofacial features of three patients with Ehlers-Danlos syndrome, dermatosparaxis type (EDS type VIIC).
Malfait, Fransiska; De Coster, Peter; Hausser, Ingrid et al

in American Journal of Medical Genetics. Part A (2004), 131(1), 18-28

Ehlers-Danlos syndrome (EDS) dermatosparaxis type (type VIIC) and the related disease of cattle dermatosparaxis, are recessively inherited connective tissue disorders, caused by a deficient activity of ... [more ▼]

Ehlers-Danlos syndrome (EDS) dermatosparaxis type (type VIIC) and the related disease of cattle dermatosparaxis, are recessively inherited connective tissue disorders, caused by a deficient activity of procollagen I N-proteinase, the enzyme that excises the N-terminal propeptide in procollagen type I, type II, and type III. Although well documented in cattle, to date only seven human cases have been recorded, most of them aged under 2 years. We document the natural history of three patients with EDS dermatosparaxis type, two of whom have been reported before the age of 2 years, and one new patient. The phenotype of the patients, and especially the facial resemblance, is striking, making this a clinically recognizable condition. The most consistent anomalies during the first years of life are premature rupture of the membranes, extreme skin fragility and easy bruising, large fontanels, blue sclerae, puffy eyelids, micrognathia, umbilical hernia, and short fingers. Joint hypermobility becomes more important with age. The children are at risk for rupture of internal organs due to soft tissue fragility, as is illustrated by different internal events in two of the three patients described here. Orofacial features include micrognathia, a frontal open bite, and gingival hyperplasia with varying degrees of hyperkeratosis. The deciduous dentition shows abnormal morphology of the molars, obliteration of the tooth pulp, and severe enamel attrition. The permanent dentition shows agenesis and microdontia of several teeth. Tooth discoloration, dysplastic roots, and tooth pulp obliteration are present in a restricted number of permanent teeth. [less ▲]

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See detailFinite element modelling of stacked thin regions with non-zero global currents
Dular, Patrick ULg; Gyselinck, Johan; Zeidan, Tarek et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(3), 707-714

Develops a method to take the eddy currents in stacked thin regions, in particular lamination stacks, into account with the finite element method using the 3D magnetic vector potential magnetodynamic ... [more ▼]

Develops a method to take the eddy currents in stacked thin regions, in particular lamination stacks, into account with the finite element method using the 3D magnetic vector potential magnetodynamic formulation. It consists in converting the stacked laminations into continuums with which terms are associated for considering the eddy current loops produced by both parallel and perpendicular fluxes. Non-zero global currents can be considered in the laminations, in particular for studying the effect of imperfect insulation between their ends. The method is based on an analytical expression of eddy currents and is adapted to a wide frequency range. [less ▲]

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See detailReactions paroxystiques du cuir chevelu.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(4), 180-5

The scalp is a unique site of the human body that may exhibit some particular physiopathological reactions. A few manifestations are paroxysmal. The main ones are the acute pruritus of pediculosis, and ... [more ▼]

The scalp is a unique site of the human body that may exhibit some particular physiopathological reactions. A few manifestations are paroxysmal. The main ones are the acute pruritus of pediculosis, and the pruritus at onset of dandruff or seborrhoeic dermatitis. One must add the telogen effuvium after solar exposure or during the post-partum, and the anagen dystrophic alopecia following chemotherapy. Other paroxysmal events include acute canitia and alopecia areata. [less ▲]

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See detailThe kallikrein-kinin system, angiotensin converting enzyme inhibitors and insulin sensitivity
Damas, Jacques ULg; Garbacki, Nancy ULg; Lefèbvre, P. J.

in Diabetes/Metabolism Research & Reviews (2004), 20(4, Jul-Aug), 288-297

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in arterial hypertension has showed that these molecules can exert, beneficial effects on insulin sensitivity and ... [more ▼]

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in arterial hypertension has showed that these molecules can exert, beneficial effects on insulin sensitivity and may reduce the occurrence of type 2 diabetes mellitus. One hypothesis explaining these effects of ACE inhibitors may relate to their capacity to interfere with bradykinin (BK) metabolism and action. BK may participate in the regulation of substrate utilization by, several tissues by improving blood flow and substrate delivery to the tissues and also by promoting translocation of glucose transporters. Moreover, BK has been shown to increase phosphorylation of insulin receptor and its cell substrates. BK also appears to improve the release of insulin. Furthermore, insulin may activate the kallikrein-kinin system, which consequently may increase its metabolic effects. However, in experimental diabetes mellitus, BK can participate to the inflammatory reaction leading to Langerhans islets destruction. In diabetes, whereas tissue kallikrein mRNA levels were reduced in several organs, an overexpression of kinin receptors, an increase in plasma levels of kininogens and kallikrein and an activation of the kinin system have all been reported. Lastly, kinins may be involved in the development of diabetic nephropathy. Reduction of kinin metabolism by ACE inhibitors might be involved in the beneficial effects exerted by these compounds in diabetic kidney functions. Copyright (C) 2004 John Wiley Sons, Ltd. [less ▲]

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See detailResponse to novelty as a predictor for drug effects: the pitfalls of some correlational studies
Quertemont, Etienne ULg; Brabant, Christian ULg; Tirelli, Ezio ULg

in Psychopharmacology (2004), 173(1-2), 221-224

In recent years, an individual's response to novelty has been postulated to predict its response to drugs of abuse and particularly to their addictive properties (Piazza et al. 1990). The hypothesis of a ... [more ▼]

In recent years, an individual's response to novelty has been postulated to predict its response to drugs of abuse and particularly to their addictive properties (Piazza et al. 1990). The hypothesis of a relationship between the response to novelty and the effects of addictive drugs was supported by a number of animal studies that reported correlations between responses to a novel environment and various effects of drugs, such as their locomotor stimulant effects, their reinforcing action or their propensity to be self-administered (Piazza et al. 1990; Klebaur et al. 2001; Carey et al. 2003; Shimosato and Watanabe 2003). Most of these studies concluded that an animal's response to novelty predicts its subsequent response to drug administration. However, correlational studies are sometimes hampered by methodological and statistical weaknesses that preclude a proper interpretation of the results. The two most frequent weaknesses are the lack of consideration for the correlation in the control group and the calculation of spurious correlations. [less ▲]

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See detailLes métaux en trace dans la tourbière du Misten. Historique de la pollution dans les Hautes Fagnes depuis le Moyen-Age
De Vleeschouwer, F.; Gérard, L.; Le Roux, G. et al

in Hautes Fagnes (2004), 256

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See detailAn energy-momentum conserving algorithm for non-linear hypoelastic constitutive models
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in International Journal for Numerical Methods in Engineering (2004), 59(1), 83-114

This paper presents an extension of the energy momentum conserving algorithm, usually developed for hyperelastic constitutive models, to the hypoelastic constitutive models. For such a material no ... [more ▼]

This paper presents an extension of the energy momentum conserving algorithm, usually developed for hyperelastic constitutive models, to the hypoelastic constitutive models. For such a material no potential can be defined, and thus the conservation of the energy is ensured only if the elastic work of the deformation can be restored by the scheme. We propose a new expression of internal forces at the element level which is shown to verify this property. We also demonstrate that the work of plastic deformation is positive and consistent with the material model. Finally several numerical applications are presented. Copyright (C) 2003 John Wiley Sons, Ltd. [less ▲]

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See detailBiocénose cutanée, peptides antimicrobiens cutanés et antiseptiques.
Flagothier, Caroline ULg; Uhoda, Emmanuelle ULg; Goffin, Véronique ULg et al

in Dermatologie Actualité (2004), 86

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See detailApport de la papyrologie à l'histoire de la médecine
Marganne, Marie-Hélène ULg

in Histoire des Sciences Médicales (2004), 38(2, Apr-Jun), 157-64

Two papyri are very interesting for Medicine history of the Antiquity. The first one (a Greek papyrus prolifically illustrated between 100 B.C. and 100 A.D.) reveals the value of the illustrators of works ... [more ▼]

Two papyri are very interesting for Medicine history of the Antiquity. The first one (a Greek papyrus prolifically illustrated between 100 B.C. and 100 A.D.) reveals the value of the illustrators of works in the Greek and Roman period and the second (the famous papyrus of Milan 300 B.C.) includes a part about the epigrams of curing. [less ▲]

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See detailDetermination of the antimony valence state in Eu10Mn6Sb13
Brown, D. E.; Johnson, C. E.; Grandjean, Fernande ULg et al

in Inorganic Chemistry (2004), 43(4), 1229-1234

The antimony-121 Mossbauer spectra of Eu10Mn6Sb13 have been measured between 2 and 295 K. Although the Zintl formalism indicates that the nine crystallographically distinct antimony sites in Eu10Mn6Sb13 ... [more ▼]

The antimony-121 Mossbauer spectra of Eu10Mn6Sb13 have been measured between 2 and 295 K. Although the Zintl formalism indicates that the nine crystallographically distinct antimony sites in Eu10Mn6Sb13 should have formal valence states of -2, -1, 0, and +1, the Mossbauer spectral isomer shifts reveal that the valence states of the 4.0 different sites are all quite similar and correspond to an average electronic configuration for antimony of 5s(1.7)5p(4.0). This configuration corresponds to an excess of negative charge on the antimony of 0.7 or an average valence of -0.7, a valence which is rather consistent with the average antimony valence of -0.61 obtained from the Zintl formalism for the nine antimony sites in Eu10Mn6Sb13. The spectra obtained between 90 and 295 K are more consistent with the absence rather than the presence of any transferred magnetic hyperfine field at the antimony. In contrast, the spectra obtained at 2 and 5 K reveal the presence of an average transferred magnetic hyperfine field of ca. 8 T, a field that arises from the ferromagnetic ordering of the near-neighbor manganese(II) ions. [less ▲]

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See detailImpact of low frequency transcranial magnetic stimulation on event-related brain potentials.
Hansenne, Michel ULg; Laloyaux, Olivier ULg; Mardaga, Solange et al

in Biological Psychology (2004), 67(3), 331-41

Contradictory findings exist concerning the inhibitory function of low frequency repetitive transcranial magnetic stimulation (rTMS). Therefore, the study examines the impact of different duration of low ... [more ▼]

Contradictory findings exist concerning the inhibitory function of low frequency repetitive transcranial magnetic stimulation (rTMS). Therefore, the study examines the impact of different duration of low frequency rTMS on ERPs. In 17 subjects, auditory ERPs were measured before and after 1 Hz rTMS delivered over the left prefrontal cortex during 10 min (600 pulses) and 15 min (900 pulses). Results showed that 15 min of 1 Hz rTMS induced a significant increase of P300 latency. There was no effect for early ERP components (N100, P200 and N200). This study confirms and extends that 1 Hz rTMS produces a real inhibitory effect only when the duration of the stimulation is about 15 min. The data suggest that rTMS modifies the speed of cognitive processing rather than the energetical aspect of information processing, and that cortical inhibition induced by the magnetic stimulation affects principally the controlled cognitive processes and not the automatic ones. [less ▲]

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See detailBovine herpesvirus 1 glycoprotein D expression in bovine upper respiratory tract mediated by a human adenovirus type 5
Gogev, S.; Georgin, J. P.; Schynts, F. et al

in Veterinary Research (2004), 35(6, Nov-Dec), 715-721

Bovine herpesvirus 1 glycoprotein D (gD) gene expression by recombinant replication defective human adenovirus type 5 (HAdV-5) was investigated in calves using indirect immunofluorescence microscopy (IIFM ... [more ▼]

Bovine herpesvirus 1 glycoprotein D (gD) gene expression by recombinant replication defective human adenovirus type 5 (HAdV-5) was investigated in calves using indirect immunofluorescence microscopy (IIFM), confocal laser scanning microscopy (CLSM) and RT-PCR. One fold intranasal instillation of HAdV-5-expressing gD in the cattle upper respiratory tract showed a short term expression of at least 5 days, but not 10 days, limited only to epithelial cells localised in the epithelium of the nasal mucosa in one out of six calves. Observed limited gene transfer into well differentiated cattle airway epithelial cells must be taken into consideration in order to enhance transfection efficiency, and consequently the vaccine potential of this vector. [less ▲]

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See detailThe Schwarz-Christoffel transformation as a tool in applied probability
Swan, Yvik ULg; Bruss, F. Thomas

in Mathematical Scientist (2004), 29

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See detailBehavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects
Quertemont, Etienne ULg; Tambour, Sophie ULg; Bernaerts, Pascale et al

in Psychopharmacology (2004), 177(1-2), 84-92

Rationale: Acetaldehyde, the first metabolite of ethanol, was recently suggested to contribute to many behavioral effects of ethanol, although few studies have directly investigated the behavioral effects ... [more ▼]

Rationale: Acetaldehyde, the first metabolite of ethanol, was recently suggested to contribute to many behavioral effects of ethanol, although few studies have directly investigated the behavioral effects of acetaldehyde itself. Objectives: The aim of the present study was to characterize the locomotor, hypnotic, anxiolytic-like and amnesic effects of acetaldehyde in C57BL/6J mice. Methods: Increasing doses of acetaldehyde (0 - 300 mg/kg) were injected intraperitoneally and their effects on a series of representative behaviors were investigated. The locomotor effects of acetaldehyde were measured in activity boxes. The duration of the loss of righting reflex was used as an index of the hypnotic effects of acetaldehyde. The anxiolytic-like effects of acetaldehyde were tested with an elevated plus-maze and the amnesic effects with the one-trial passive avoidance test. Finally, brain and blood acetaldehyde concentrations were assessed. Results: Acetaldehyde induced a significant hypolocomotor effect at 170 mg/kg and higher doses. In addition, the hypnotic effects of acetaldehyde were demonstrated by a loss of righting reflex after the administration of 170 and 300 mg/kg acetaldehyde. The elevated plus-maze showed that acetaldehyde does not possess anxiolytic-like properties. Finally, acetaldehyde ( 100 - 300 mg/kg) dose-dependently altered memory consolidation as shown by a reduced performance in the passive avoidance test. Conclusions: The present results show that acetaldehyde induces sedative, hypnotic and amnesic effects, whereas it is devoid of stimulant and anxiolytic-like properties in C57BL/6J mice. However, the behavioral effects of acetaldehyde after intraperitoneal administration were apparent at very high brain concentrations. The present results also indicate that acetaldehyde is unlikely to be involved in the anxiolytic properties of ethanol in mice. [less ▲]

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See detailPrise en charge anesthesique des craniotomies en etat vigile.
Bonhomme, Vincent ULg; Born, J.-D.; Hans, Pol ULg

in Annales Françaises d'Anesthésie et de Réanimation (2004), 23(4), 389-94

This review article presents a detailed analysis of patients' management for awake craniotomy, at the light of the available data in the literature and the authors' experience. Indications of this type of ... [more ▼]

This review article presents a detailed analysis of patients' management for awake craniotomy, at the light of the available data in the literature and the authors' experience. Indications of this type of surgery are discussed as well as anaesthetic management itself, from preoperative assessment of the patient to peroperative concerns. Anaesthetic strategy, choice of anaesthetic agents, anaesthetic technique, and management of the airway and possible complications are discussed. The authors emphasize the tricky aspect of the procedure, the necessity of rigorous patient selection and good preparation. They emphasize the need for controlled studies to validate the proposed techniques. [less ▲]

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See detailReceptor-based screening assays: New perspectives in anti-doping control
Scippo, Marie-Louise ULg; Willemsen, Philippe; Danyi, Sophie ULg et al

in Chromatographia (2004), 59(Suppl. S), 23-27

The so-called "growth promoters", steroid hormones and beta-agonists, are currently controlled by using hyphenated analytical methods (chromatography coupled to mass spectrometry) or, sometimes for ... [more ▼]

The so-called "growth promoters", steroid hormones and beta-agonists, are currently controlled by using hyphenated analytical methods (chromatography coupled to mass spectrometry) or, sometimes for screening purposes, on immunoassays. These methods are often too specific to allow an effective multianalyte control. To develop more efficient assays, the use of hormonal receptors as detection tools (receptor-based binding assays and cell-based assays) is proposed. Receptor-based assays represent useful tools in screening of hormonal residues in food, but they could also be applied in doping control (to detect "new" hormonal substances). Furthermore, these assays could be used to monitor the human exposure to endocrine disruptors. [less ▲]

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See detailSpawning movements of European grayling Thymallus thymallus in the River Aisne (Belgium)
Ovidio, Michaël ULg; Parkinson, Denis; Sonny, Damien et al

in Folia Zoologica (2004), 53(1), 87-98

In three consecutive years (1998 to 2000), 20 adult grayling Thymallus thymallus (L.) (FL +/- SD: 326 +/- 43 mm) were radio-tracked during circum reproduction period (February to May) in the River Aisne ... [more ▼]

In three consecutive years (1998 to 2000), 20 adult grayling Thymallus thymallus (L.) (FL +/- SD: 326 +/- 43 mm) were radio-tracked during circum reproduction period (February to May) in the River Aisne, Belgium. Before the spawning period, grayling remained consistently in the pool-riffle sequence in which they had been captured. Pre-spawning migration time extended from 7 to 29 March. Distances travelled during the spawning migration ranged from 70 to 4980 in (mean +/- S.E.: 1234 +/- 328 m). Spawning migrations stalled under conditions of decreasing water level and increasing water temperature in a thermal range (daily mean Tdegrees) from 5 to 8 degreesC. Spawners remained from 1 to 31 days (mean +/- S.D.: 10.4 +/- 9.8 days) at the spawning grounds and performed a post-spawning homing from 28 March to 18 April in decreasing water flow and in a thermal range (daily mean Tdegrees) from 7 to 11 degreesC. This study demonstrates that migration patterns of grayling are similar between years, but with a timing adjusted as a response to annual variations of the hydroclimatic conditions. [less ▲]

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See detailModulus of elasticity for service and accident conditions
Schneider, Ulrich; Schwesinger, P.; Debicki, Gérard et al

in Materials and Structures (2004), 37

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See detailAromatic Side-Chain Interactions In Proteins: Near- And Far-Sequence Tyr-X Pairs
Meurisse, R.; Brasseur, Robert ULg; Thomas, Annick ULg

in Proteins-Structure Function and Genetics (2004), 54(3), 478-90

In the present study, an extensive analysis of the aromatic Tyr-X interactions is performed on a data set of 593 PDB structures, X being Phe, His, Tyr, and Trp. The nonredundant Tyr-X pairs (2645) were ... [more ▼]

In the present study, an extensive analysis of the aromatic Tyr-X interactions is performed on a data set of 593 PDB structures, X being Phe, His, Tyr, and Trp. The nonredundant Tyr-X pairs (2645) were retained and separated by both the residue distance in the sequence and the secondary structures they bridge. Similar to the Phe-X and His-X pairs, the far-sequence Tyr-X pairs (X partner > five apart in the sequence: 74%) show comparable secondary structures and conformers for either type of X partner, in contrast with the near-sequence Tyr-X pairs (26%). As the Phe-X pairs, the near-sequence Tyr-X pairs stabilize secondary structures, mainly the alpha- helices (positions 1, 3, and 4) and the beta-strands (position 2). Like the Phe-X and His-X pairs, most far-sequence Tyr-X pairs (34%) bridge beta-strands and only 11% bridge helices. As for the Phe-X and the His-X pairs, the X partners of the far-sequence Tyr-X pairs are frequently "above" the tyrosine ring with tilted and normal rings, whereas the X partner of the near-sequence Tyr-X pairs gradually moves from the "aside" to the "above" location, together with a progressive decrease of normal and increase of parallel rings, respectively. Unlike the His-X pairs, the interactions of the hetroatom in Tyr-X pairs are only favored with a sequence position +4 and over, owing to the spatial accessibility of the heteroatom. [less ▲]

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See detailLe nouveau régime des décisions étrangères dans le Code de droit international privé
Wautelet, Patrick ULg

in Revue de Droit Judiciaire et de la Preuve = Tijdschrift voor Procesrecht en Bewijsrecht (2004)

In this paper, I offer a thorough analysis of the provisions of the Code of Private International law (Act of 16 July 2004) regarding the recognition and enforcement of foreign judgments in Belgium (artt ... [more ▼]

In this paper, I offer a thorough analysis of the provisions of the Code of Private International law (Act of 16 July 2004) regarding the recognition and enforcement of foreign judgments in Belgium (artt. 22 ff). The emphasis is on the differences with the regime which prevailed before the entry into force of the Code. At the same time I indicate what differences remain between the regime put in place by the Code and the one prevailing within the European Judicial Area, with Regulation 44/2001 as main comparison point. [less ▲]

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See detailPropriété et union libre:vers un affaiblissement de la preuve par le titre
Dehalleux, Virginie ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2004)

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See detailLa route métastatique du mélanome.
Quatresooz, Pascale ULg; Claessens, Nadine; Arrese Estrada, Jorge ULg et al

in Skin (2004), 7

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See detailLe site du Trou Al'Wesse (comm. de Modave) : Campagne de Fouille 2004
Miller, Rebecca ULg; Zwyns, Nicolas; Otte, Marcel ULg

in Notae Praehistoricae (2004), 24

We present the discovery context of Neolithic ceramic sherds from stratum 4 (attributed to the Late Mesolithic) at Trou Al'Wesse. The spatial distribution of the archaeological materials, as well as ... [more ▼]

We present the discovery context of Neolithic ceramic sherds from stratum 4 (attributed to the Late Mesolithic) at Trou Al'Wesse. The spatial distribution of the archaeological materials, as well as stratigraphic data, demonstrate that these sherds are not associated with the Mesolithic assemblage. Thestratigraphy also shows that, near the cliff face, there is no mixing between the two occupations. [less ▲]

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See detailCyclodextrins as a potential carrier in drug nebulization
Evrard, Brigitte ULg; Bertholet, P.; Guéders, Maud ULg et al

in Journal of Controlled Release (2004), 96(3), 403-410

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailNew developments on thromboxane and prostacyclin modulators. Part I: thromboxane modulators
Dogné, Jean-Michel ULg; De leval, X.; Hanson, Julien ULg et al

in Current Medicinal Chemistry (2004), 11

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See detailL’héritage et l’archive
Badir, Sémir ULg; Baetens, Jan

in Protée (2004), 32(2), 5-8

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See detailDistribution of bacteria and associated minerals in the gill chamber of the vent shrimp Rimicaris exoculata and related biogeochemical processes
Zbinden, M.; Le Bris, N.; Gaill, F. et al

in Marine Ecology. Progress Series (2004), 284

The shrimp Rimicaris exoculata dominates the megafauna of some Mid-Atlantic Ridge hydrothermal vent fields. This species harbours a rich bacterial epibiosis inside its gill chamber. At the 'Rainbow' vent ... [more ▼]

The shrimp Rimicaris exoculata dominates the megafauna of some Mid-Atlantic Ridge hydrothermal vent fields. This species harbours a rich bacterial epibiosis inside its gill chamber. At the 'Rainbow' vent site (36degrees 14.0'N), the epibionts are associated with iron oxide deposits. Investigation of both bacteria and minerals by scanning electron microscopy (SEM) and X-ray microanalysis (EDX) revealed 3 distinct compartments in the gill chamber: (1) the lower pre-branchial chamber, housing bacteria but devoid of minerals; (2) the 'true' branchial chamber, containing the gills and devoid of both bacteria and minerals; and (3) the upper pre-branchial chamber, housing the main ectosymbiotic bacterial community and associated mineral deposits. Our chemical and temperature data indicated that abiotic iron oxidation appears to be kinetically inhibited in the environment of the shrimps, which would explain the lack of iron oxide deposits in the first 2 compartments. We propose that iron oxidation is microbially promoted in the third area. The discrepancy between the spatial distribution of bacteria and minerals suggests that different bacterial metabolisms are involved in the first and third compartments. A possible explanation lies in the modification of physico-chemical conditions downstream of the gills that would reduce the oxygen content and favours the development of bacterial iron-oxidizers in this Fe-II-rich environment. A potential role of such iron-oxidizing symbionts in the shrimp diet is suggested. This would be unusual for hydrothermal ecosystems, in which most previously described symbioses rely on sulphide or methane as an energy source. [less ▲]

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See detailUpdating trends in cutaneous cancers in south-east Belgium.
Uhoda, Isabelle; Quatresooz, Pascale ULg; Fumal, Isabelle et al

in Oncology Reports (2004), 12(1), 111-4

From data collected in a dermatopathology laboratory, the ratios between the numbers of specific cancers represent good markers for identifying any epidemiological shift in their prevalence and incidence ... [more ▼]

From data collected in a dermatopathology laboratory, the ratios between the numbers of specific cancers represent good markers for identifying any epidemiological shift in their prevalence and incidence among the reference population. The objective of the present study was to assess the ratios of the annual incidence of skin cancers in the Mosan region and Ardennes of Belgium over the past 6 years, and to compare the data with previous similar evaluations. A total of 7,640 skin cancers were collected and compared with regard to age and gender. Changes in time show that the trend of the increase in incidence of malignant melanoma (MM) is more impressive than that of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). The age distribution of BCC and SCC confirms the increasing risk with ageing. By contrast, there is a steady decrease over the past decade in the mean age for MM, teenagers and young adults now form an expanding proportion of MM patients. There is an ongoing trend in diagnosing an increased number of skin cancers in our laboratory. This trend is particularly obvious for MM affecting young adults. [less ▲]

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See detailRole of lipopeptides produced by Bacillus subtilis GA1 in the reduction of grey mould disease caused by Botrytis cinerea on apple
Toure, Y.; Ongena, MARC ULg; Jacques, Philippe ULg et al

in Journal of Applied Microbiology (2004), 96(5), 1151-1160

AIM: Test of Bacillus subtilis strain GA1 for its potential to control grey mould disease of apple caused by Botrytis cinerea. METHODS AND RESULTS: GA1 was first tested for its ability to antagonize in ... [more ▼]

AIM: Test of Bacillus subtilis strain GA1 for its potential to control grey mould disease of apple caused by Botrytis cinerea. METHODS AND RESULTS: GA1 was first tested for its ability to antagonize in vitro the growth of a wide variety of plant pathogenic fungi responsible for diseases of economical importance. The potential of strain GA1 to reduce post-harvest infection caused by B. cinerea was tested on apples by treating artificially wounded fruits with endospore suspensions. Strain GA1 was very effective at reducing disease incidence during the first 5 days following pathogen inoculation and a 80% protection level was maintained over the next 10 days. Treatment of fruits with an extract of GA1 culture supernatant also exerted a strong preventive effect on the development of grey mould. Further analysis of this extract revealed that strain GA1 produces a wide variety of antifungal lipopeptide isomers from the iturin, fengycin and surfactin families. A strong evidence for the involvement of such compounds in disease reduction arose from the recovery of fengycins from protected fruit sites colonized by bacterial cells. CONCLUSIONS: The results presented here demonstrate that, despite unfavourable pH, B. subtilis endospores inoculated on apple pulp can readily germinate allowing significant cell populations to establish and efficient in vivo synthesis of lipopeptides which could be related to grey mould reduction. SIGNIFICANCE AND IMPACT OF THE STUDY: This work enables for the first time to correlate the strong protective effect of a particular B. subtilis strain against grey mould with in situ production of fengycins in infected sites of apple fruits. [less ▲]

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See detailAnemie: cardiovasculaire risicofactor?
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2004), 16(2), 53-62

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See detailSpontaneous arachnoid cyst rupture in a previously asymptomatic child: a case report
Poirrier, Anne-Lise ULg; Ngosso-Tetanye, I.; Mouchamps, M. et al

in European Journal of Paediatric Neurology : Official Journal of the European Paediatric Neurology Society (2004), 8(5), 247-251

Arachnoid cysts are benign congenital cavities arising in the subarachnoid space. Non-traumatic subdural effusion of cerebrospinal fluid is a rare complication requiring surgical treatment. Case Report: A ... [more ▼]

Arachnoid cysts are benign congenital cavities arising in the subarachnoid space. Non-traumatic subdural effusion of cerebrospinal fluid is a rare complication requiring surgical treatment. Case Report: A 15-year-old boy was admitted to the hospital because of symptoms related to acute intracranial hypertension (headache and vomiting). The cerebral CT-scan revealed a subdural hygroma adjoining a voluminous Sylvian arachnoid cyst. Two arachnoid cysts were incidentally discovered 11 years before this dramatic complication. Moreover, the patient had suffered a cerebral concussion 2 years earlier, but interestingly did not develop cystic hemorrhage or rupture, contrary to numerous cases previously described in the literature. The location of the cysts and their regular follow-up did not allow foreseeing a cystic rupture. Hygroma evacuation was first performed after which a subdural peritoneal. shunting, using a programmable opening pressure valve, was implanted. Spontaneous rupture into the subdural space represents an unusual complication of arachnoid cysts. Clinical aspects, radiographic findings, pathogenesis and surgical management are described. It is important to point out that subdural hygroma or haematoma should never be excluded in the absence of trauma history, even in the case of small non-progressive cysts regularly supervised. (C) 2004 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailContact and photocontact allergy to ketoprofen. The Belgian experience.
Matthieu, L.; Meuleman, L.; Van Hecke, E. et al

in Contact Dermatitis (2004), 50(4), 238-241

Topical ketoprofen (KP) is widely used because of its anti-inflammatory effect. However, photocontact dermatitis is a side-effect. Between May 2001 and June 2002, the Belgian Contact & Environmental ... [more ▼]

Topical ketoprofen (KP) is widely used because of its anti-inflammatory effect. However, photocontact dermatitis is a side-effect. Between May 2001 and June 2002, the Belgian Contact & Environmental Dermatitis Group conducted a prospective, open patch and photopatch test study in 20 patients suspected of KP dermatitis. Severe skin symptoms requiring systemic corticotherapy occurred in 47%. 5 patients were hospitalized. 1 patient showed prolonged photosensitivity. All patients were tested with KP and the other constituents of KP gel. Attribution to KP was demonstrated in all cases. Patch and photopatch tests with KP 2% in petrolatum showed contact photoallergy in 17 patients, contact allergy in 1 patient and photoaggravated contact allergy in 2 patients. 5 patients also reacted to the fragrance components lavender (Lavandula augustifolia) oil and/or neroli (Citrus aurantium dulcis) oil 5% in alcohol. However, in 4 of these, irritant reactions to the ethanolic dilutions could not be ruled out. Additional tests with 3 non-steroidal anti-inflammatory drugs without benzophenone structure ibuprofen, naproxen and diclofenac identified only 1 contact allergic reaction to diclofenac. Cross-reactivity to the substituted benzophenones, oxybenzone and sulisobenzone occurred only to the first in less than 30% of the patients. A high frequency (69%) of contact allergy to fragrance mix was found. Dermatologists should be aware of the severity of photoallergic reactions to KP and the risk of cross-sensitization. [less ▲]

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See detailRisk evaluation of the transmission of the avian influenza virus to humans
Saegerman, Claude ULg; Meulemans, G.; Van Reeth, K. et al

in Annales de Médecine Vétérinaire (2004), 148(2), 65-77

Since mid-december 2003, an epizootic of highly pathogenic avian influenza (type A, sub-type H5N1) occurs in eastern and south-eastern Asia. This epizootic is historically unprecedented in its virulence ... [more ▼]

Since mid-december 2003, an epizootic of highly pathogenic avian influenza (type A, sub-type H5N1) occurs in eastern and south-eastern Asia. This epizootic is historically unprecedented in its virulence, geographical spread, and economic consequences for the agricultural sector. Implications for human health were registered in Vietnam and in Thailand. This paper summarizes the current knowledge about the risk evaluation of the transmission of avian influenza virus to humans. The current asian epizootic has highlighted the key role of global health information systems and also the need for exhaustive notification of human and animal cases. It reinforces the concept of veterinary public health. [less ▲]

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See detailCitrate vs. heparin for anticoagulation in continuous venovenous hemofiltration: a prospective randomized study
Monchi, Mehran; Berghmans, Denis; Ledoux, Didier ULg et al

in Intensive Care Medicine (2004), 30(2), 260-265

Abstract Objective: To compare the efficacy and safety of adjusted-dose unfractionated heparin with that of regional citrate anticoagulation in intensive care patients treated by continuous venovenous ... [more ▼]

Abstract Objective: To compare the efficacy and safety of adjusted-dose unfractionated heparin with that of regional citrate anticoagulation in intensive care patients treated by continuous venovenous hemofiltration (CVVH). Design and setting: Prospective, randomized, clinical trial in a 32-bed medical and surgical ICU in a university teaching hospital. Patients: ICU patients with acute renal failure requiring continuous renal replacement therapy, without cirrhosis, severe coagulopathy, or known sensitivity to heparin. Interventions: Before the first CVVH run patients were randomized to receive anticoagulation with heparin or trisodium citrate. Patients eligible for another CVVH run received the other study medication in a crossover fashion until the fourth circuit. Measurements and results: Fortynine circuits (hemofilters) were analyzed: 23 with heparin and 26 with citrate. The median lifetime of hemofilters was 70 h (interquartile range 44–140) with citrate anticoagulation and 40 h (17–48) with heparin (p=0.0007). One major bleeding occurred during heparin anticoagulation and one metabolic alkalosis (pH=7.60) was noted with citrate after a protocol violation. Transfusion rates (units of red cells per day of CVVH) were, respectively, 0.2 (0.0–0.4) with citrate and 1.0 (0.0–2.0) with heparin (p=0.0008). Conclusions: Regional citrate anticoagulation seems superior to heparin for the filter lifetime and transfusion requirements in ICU patients treated by continuous renal replacement therapy. [less ▲]

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See detailPrise en charge anesthésique pour chimiothérapie hyperthermique intrapéritonéale peropératoire
Baumann, Antoine; Joris, Jean ULg

in Praticien en Anesthésie Réanimation (Le) (2004), 8(5), 357-362

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See detailCaseuse lymfadenitis bij kleine herkauwers
Imberechts, H.; Decostere, A.; Dierickx, K. et al

in Vlaams Diergeneeskundig Tijdschrift (2004), 73

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See detailClinical pharmacokinetics of once-daily molsidomine - From immediate-release to prolonged-release once-daily formulations
Herchuelz, André; Carreer-Bruhwyler, Fabienne; Crommen, Jacques ULg et al

in American Journal of Drug Delivery (2004), 2(2), 131-141

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See detailL'automesure de la pression artérielle: un plus pour l'appreciation du risque cardiovasculaire?
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (2004), 16(2), 89-90

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See detailProtective effect of EGB 761 against oxidative phosphorylation damages of brain mitochondria after Anoxia/reoxygenation in vivo and in vitro
Du, G.; Willet, K.; Jarmuszkiewicz, W. et al

in Toxicology Mechanisms & Methods (2004), 14

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See detailPerquisitions et droits de la défense : une remise en question des pratiques par la Cour européenne des droits de l’homme ?
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2004)

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du ... [more ▼]

Confrontation de la jurisprudence belge en matière de perquisitions à la jurisprudence de la Cour européenne des droits de l'homme, en particulier sous l'angle des mentions du mandat de perquisition et du déroulement de la perquisition. [less ▲]

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See detailScreening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class IHDAC profiles between epithelial and stromal cells
Waltregny, David ULg; North, Brian; Van Mellaert, Frank et al

in European Journal of Histochemistry (2004), 48(3, Jul-Sep), 273-290

Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major epigenetic event that controls eukaryotic gene transcription ... [more ▼]

Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major epigenetic event that controls eukaryotic gene transcription. Inappropriate deacetylation mediated by HDACs has been associated with profound alterations in cellular biology. We have thus hypothesized that an altered HDAC expression may favor cancer development/progression. To test this possibility, we have sought to screen the expression profiles of several class I and class 11 HDACs (HDAC1-8) in DU-145, PC-3 and LNCaP human prostate cancer cell lines as well as in matched malignant and nonmalignant prostate tissues by use of real time RT-PCR, immunoblot and immunohistochemistry. All HDAC transcripts tested were detected at various levels in all prostate cancer cell lines and tissue samples analyzed. In prostate tissues, the abundance of HDAC1 protein, which was exclusively expressed in the cell nucleus, was similar in normal and malignant epithelial cells, but was usually lower in stromal cells. Unexpectedly, HDAC8, another class I HDAC, was not detected in epithelial cells but was uniquely expressed in the cytoplasm of stromal cells, HDAC5, a class II HDAC involved in myogenesis, was not detected in the tissues. Altogether, our findings indicate that epithelial and stromal cells exhibit distinct class I HDAC expression profiles, and the abundance of HDAC1 is not altered in human prostate cancer. In addition, our observations are the first to demonstrate the prominently cytosolic distribution of a class I HDAC, HDAC8. [less ▲]

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See detailINFECTIONS ET PROPHYLAXIES ANTIINFECTIEUSES DANS LA DRÉPANOCYTOSE
Lepage, P; DRESSE, Marie-Françoise ULg; FORGET, Patricia ULg et al

in Revue Médicale de Liège (2004), 59(3), 145-148

Bacterial infections remain a major cause of morbidity and mortality among young children with sickle cell susceptibility to infections is mainly observed in homozygous sickle cell disease. The incidence ... [more ▼]

Bacterial infections remain a major cause of morbidity and mortality among young children with sickle cell susceptibility to infections is mainly observed in homozygous sickle cell disease. The incidence of bacteremias in children under 3 years of age is ~8 events/100 patient-years among homozygous subjects and ~5 events/100 patient-years among those with SC hemoglobinopathy. Pneumococci and Salmonellae are the most frequently isolated bacteria. Severe clinical manifestations include septicemia, meningitis, osteomyelitis and pneumonia. M. Pneumoniae and C. Pneumoniae infections may be severe and may induce acute chest syndrome. The high incidence and severity of bacterial infections in these children justify prevention efforts by antibiotic prophylaxis and vaccination. The efficacy of oral penicillin prophylaxis against pneumococcal infections has been well demonstrated and is now recommended from 3 months of age. The antipneumococcal conjugate vaccine has been shown to be safe and immunogenic in young infants. [less ▲]

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See detailSex in the media
Gratia, Jean-Pierre; Thiry, Marc ULg

in Scientist (Philadelphia, Pa.) (2004), 18

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See detailRégime alimentaire des Plecotus en périodes préhivernale et hivernale en Belgique
MOTTE, Gregory; Libois, Roland ULg

in Symbioses (2004), 10

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See detailLe Paléolithique supérieur de la Moldavie
Noiret, Pierre ULg

in Anthropologie (L') (2004), 108(3-4, JUL-OCT), 425-470

Upper Palaeolithic lithic industries in Moldavia primarily can be attributed to traditional culture's known across Europe: (Aurignacian and Gravettian. followed by Epigravettian). However, they coexsist ... [more ▼]

Upper Palaeolithic lithic industries in Moldavia primarily can be attributed to traditional culture's known across Europe: (Aurignacian and Gravettian. followed by Epigravettian). However, they coexsist with other industries marked by the presence of bifacially retouched tools, in reportedly early contexts, but which are poorly dated and often heterogeneous. Such industries, considered in the literature as belonging to three of four vaguely defined cultural traditions, most probably should be grouped in a single cultural entity, the Prut culture. The main occupations can, with our current state of knowledge, be classified in a well-supported and well-dated regional chronostratigraphic scheme; they are attributed to Typical Aurignacian (33 000-29 000 BP), Gravettian (29 500-23 000 BP), Early Epigravettian (20 000-17 000 BP) and Late Epigravettian (13 500-11 000 BP). Data from Moldavia also are relevant to broad cultural phenomena: the Aurignacian exploration of a territory extending from to the centre of the Russian plain and to the northern foothills of the Ural (beginning at 33 000 BP), the multiple geographic origins of the Gravettian (around 30 000 BP), the presence of non-Aurignacian and non-Gravettian lithic industries (with bifacial tools, likely around 27 000-26 000 13P), the reappearance of technological characteristics of "Aurignacoid" aspect (from 21000 13P), and the massive return to a tradition with backed tools (from 20 000 BP). The data from Moldavia plays a role ill a broad palaeohistory, at a continental scale. (C) 2004 Elsevier SAS. Tous droits reserves. [less ▲]

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See detailInterassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis.
Joossens, Sofie; Daperno, Marco; Shums, Zakera et al

in Clinical Chemistry (2004), 50(8), 1422-5

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See detailA family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects
Lange, C.; Van Steen, Kristel ULg; Andrew, T. et al

in Statistical Applications in Genetics and Molecular Biology (2004), 3(1), 17

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See detailPrincipal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation.
Lecut, Christelle ULg; Schoolmeester, Anne; Kuijpers, Marijke J E et al

in Arteriosclerosis, Thrombosis, and Vascular Biology (2004), 24(9), 1727-33

OBJECTIVE: High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of alpha2beta1 and alphaIIbbeta3 integrin ... [more ▼]

OBJECTIVE: High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of alpha2beta1 and alphaIIbbeta3 integrin activation during thrombus formation on collagen. METHODS AND RESULTS: Blockade of glycoprotein (GP) VI by 9O12 antibody or of P2Y purinergic receptors permitted platelet adhesion but reduced aggregate formation, fibrinogen binding, and activation of alpha2beta1 and alphaIIbbeta3, as detected with antibodies IAC-1 and PAC1 directed against activation-dependent epitopes of these integrins. Combined blockade of GPVI and P2Y receptors and thromboxane formation abolished integrin activation but still allowed adhesion of morphologically unstimulated, nonprocoagulant platelets. Exogenous ADP partly restored the suppressive effect of GPVI blockade on integrin alpha2beta1 and alphaIIbbeta3 activation. Adhesion was fully inhibited only with simultaneous blocking of GPVI and alpha2beta1, indicating that the integrin can support platelet-collagen binding in the absence of its activation. Blockade or absence of GPIbalpha only moderately influenced integrin activation and adhesion unless GPVI was inhibited. CONCLUSIONS: GPVI- and autocrine-released ADP induce affinity changes of alpha2beta1 and alphaIIbbeta3 during thrombus formation on collagen under flow. These integrin changes are dispensable for adhesion but strengthen platelet-collagen interactions and thereby collagen-induced platelet activation. Integrin activation during thrombus formation on collagen was studied using fluorescent-labeled antibodies IAC-1 and PAC1 directed against activation-dependent epitopes of alpha2beta1 and alphaIIbbeta3 integrin, respectively. Glycoprotein VI blockade by 9O12 antibody or P2Y ADP receptors reduced integrin activation along with aggregate formation and fibrinogen binding but not alpha2beta1-dependent adhesion. [less ▲]

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See detailTransmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease.
Esters, Nele; Pierik, Marie; Van Steen, Kristel ULg et al

in American Journal of Gastroenterology (2004), 99(2), 299-305

OBJECTIVES: Three single nucleotide polymorphisms (SNPs) in CARD15 have been independently associated with Crohn's disease (CD). Since nothing is known about the transmission of these variants within ... [more ▼]

OBJECTIVES: Three single nucleotide polymorphisms (SNPs) in CARD15 have been independently associated with Crohn's disease (CD). Since nothing is known about the transmission of these variants within families, this was the subject of our study in Flemish patients with inflammatory bowel disease (IBD) and their healthy relatives. METHODS: A cohort of 1,670 individuals (570 CD, 173 UC, 165 healthy controls, 762 first-degree unaffected relatives of CD patients) was genotyped for Arg702Trp, Gly908Arg, and Leu1007fsinsC. Mutant allele and carrier frequencies were compared between groups. Segregation patterns were compared using a bivariate Dale model. RESULTS: The carrier prevalence of CARD15 variants for CD patients was 46.3%, compared to 20.6% for healthy controls and 22.0% for ulcerative colitis (UC) patients (both p < 0.0001). An increased carriage rate of CARD15 variants was observed in unaffected relatives of CD patients (37.3%; p < 0.0001 vs controls), although this was significantly lower than in the CD patients (p = 0.001). Paternal transmission gave a 5.17-fold higher chance for the child to develop the disease compared to maternal transmission (95% CI [1.59, 16.78]; p = 0.0063). UC patients belonging to mixed IBD families carried significantly more mutations (42.3%) compared to other UC patients (18.4%) (p < 0.01). CONCLUSIONS: Maternal transmission of the CARD15 variant allele is associated with a lower proportion of affected individuals compared to paternal transmission. Therefore, maternal transmission does not carry an increased risk of transmission as does paternal transmission. The increased mutation carriage in unaffected siblings of CD patients and in UC patients belonging to mixed families suggests that other factors than CARD15 contribute to the eventual disease expression. [less ▲]

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See detailEvaluation of three serum i-ELISA's using monoclonal antibodies and protein G as peroxidase conjugate for the diagnosis of bovine brucellosis
Saegerman, Claude ULg; De Waele, L.; Gilson, D. et al

in Veterinary Microbiology (2004), 100

Three i-ELISAs using LPS, the immunodominant component of Brucella abortus, were developed with three different conjugates: monoclonal antibodies 1C8 (anti-bovine IgG(1)) and 3H3 (mainly specific for ... [more ▼]

Three i-ELISAs using LPS, the immunodominant component of Brucella abortus, were developed with three different conjugates: monoclonal antibodies 1C8 (anti-bovine IgG(1)) and 3H3 (mainly specific for bovine IgG(2) but also reacting with IgG(1)) and protein G (reacts with both bovine IgG subclasses). Using a cut-off value of 2.5U/ml, the i-ELISA with 3H3 as conjugate had a specificity (95% CI: 98.32-99.63%) that was significantly higher than the same assay with 1C8 (95% CI: 96.08-98.26%) or PG (95% CI: 95.83-98.09%). In areas where false positive serological reactions (FPSR) were common, the specificity of the i-ELISAs decreased significantly. The specificity of the i-ELISAs increased with the age of the animals tested, irrespective of the conjugate. The specificity of the i-ELISAs and traditional tests was also examined using sera from animals infected per os with bacteria bearing LPS similar to the Brucella LPS. It appeared that Yersinia enterocolitica O:9, Xanthomonas maltophilia and Salmonella urbana infections induced FPSR both in the i-ELISAs and in the traditional tests, but the 3H3 assay was significantly less prone to produce false positive reactions than the 1C8 and PG assays. The i-ELISAs were more sensitive, allowed earlier detection, and were more persistent than the traditional serological tests both in experimentally and naturally Brucella-infected animals. Weekly i-ELISA monitoring of experimentally infected pregnant heifers (previously vaccinated or not) allowed a prediction of abortion. Furthermore, the 1C8 assay showed significantly higher titres irrespective of day post-infection and vaccination status. The accuracy of the assay could be improved by making use of additional information (e.g. animal age or conjugate) and by selecting appropriate cut-off points on the basis of the prevailing epidemiological situation. The i-ELISAs appear an appropriate choice in order to maintain an official brucellosis-free status because of their sensitivity, early detection and long persistence and, for the same reasons, seem especially valuable for the detection of latent carriers (i.e. animals classified negative by classical serological tests) among imported [less ▲]

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See detailInvestigation of non-covalent interactions between paramagnetic complexes and human serum albumin by electrospray mass spectrometry
Henrotte, Virginie; Laurent, Sophie ULg; Gabelica, Valérie ULg et al

in Rapid Communications in Mass Spectrometry : RCM (2004), 18(17), 1919-1924

Stable gadolinium(III) chelates are nowadays routinely used as contrast agents for magnetic resonance imaging (MRI). Their non-covalent binding to human serum albumin (HSA) has shown to improve their ... [more ▼]

Stable gadolinium(III) chelates are nowadays routinely used as contrast agents for magnetic resonance imaging (MRI). Their non-covalent binding to human serum albumin (HSA) has shown to improve their efficacy. Non-covalent interactions lead to complex formation that can be quantified by several techniques that are mostly tedious and time-consuming. In this study, electrospray ionization mass spectrometry (ESI-MS) was used to investigate the interaction between HSA and several gadolinium(III) complexes. The results were compared with those obtained in the liquid phase. Four gadolinium complexes were investigated: Gd-DTPA 1, Gd-C4Me-DTPA 2, Gd-EOB-DTPA 3, and MP-2269 4. Relaxometry studies show that complexes 1 and 2 have no significant affinity for HSA, while complexes 3 and 4 have increasing affinities for the protein. 1:1 and 1:2 complexes between HSA and MP-2269 were detected by ESI-MS for a twofold excess of the contrast agent, whereas a ligand/protein molar ratio of 4:1 was necessary to observe a 1:1 stoichiometry for Gd-EOB-DTPA, an observation that is in good agreement with the known weaker affinity of the contrast agent for the protein. At a fourfold molar excess, no supramolecular complex was observed for Gd-DTPA I and Gd-C4Me-DTPA 2; a tenfold molar excess was necessary to detect a 1:1 complex, confirming the very weak affinity of these contrast agents for HSA. [less ▲]

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See detailTrace metal and stable isotope measurements (delta C-13 and delta N-15) in the harbour porpoise Phocoena phocoena relicta from the Black Sea
Das, Krishna ULg; Holsbeek, Ludo; Browning, Julie et al

in Environmental Pollution (2004), 131(2),

Stable carbon and nitrogen isotopes (delta(13)C and delta(15)N) and trace metals (Cd, Zn, Cu, Fe, Se, and Hg) were analysed in the tissues of 46 harbour porpoises (Phocoena phocoena relicta) caught in ... [more ▼]

Stable carbon and nitrogen isotopes (delta(13)C and delta(15)N) and trace metals (Cd, Zn, Cu, Fe, Se, and Hg) were analysed in the tissues of 46 harbour porpoises (Phocoena phocoena relicta) caught in fishing nets along the Ukrainian coasts between 1997 and 1998. Mean delta(13)C values differed significantly between male and female harbour porpoises suggesting a trophic segregation between sexes with a more coastal distribution for females at least during their gestation and nursing periods. Hepatic Hg was correlated to delta(13)C measurements, reflecting a different exposure linked to coastal vs offshore feeding habitats. A geographical comparison with existing data from other regions showed general low levels of Hg, Cd, Cu and Zn in the tissues of harbour porpoises from the Black Sea compared to other Atlantic and North Sea areas. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailTransposition de la Directive Nitrate (CE) en Région wallonne : azote potentiellemnt lessivable de référence pour les sols cultivés en Région wallonne
Vandenberghe, Christophe ULg; Marcoen, Jean Marie ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8

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See detailTerrestrial versus aquatic foraging in juvenile Alpine newts (Triturus alpestris)
Denoël, Mathieu ULg

in Ecoscience (2004), 11(4), 404-409

Many species of newts and salamanders forage in both terrestrial and aquatic environments during their life. However, the relative benefits of the two foraging patterns remain unknown because all previous ... [more ▼]

Many species of newts and salamanders forage in both terrestrial and aquatic environments during their life. However, the relative benefits of the two foraging patterns remain unknown because all previous studies have focused on only one habitat. The aim of this study was to find out which foraging tactic is the most successful in terms of energy intake. To this end, I analyzed trophic habits in metamorphosed juveniles in the Alpine newt, Triturus alpestris veluchiensis, inhabiting an alpine lake (Drakolimni) and the surrounding lands (Tymphi Mountains, northern Greece). The diet of the newts reflected the range of prey available in the two habitats, but aquatic newts also foraged on invertebrates that fell on the water surface. The two lifestyles have different energy outcomes. Terrestrial invertebrates provided high energy gains mainly to terrestrial juveniles because of the low number of this prey type in the lake. However, terrestrial juveniles are expected to suffer higher mortality (freezing on land is more probable than in deep waters) and a lower energy intake when air temperature is low, i.e., the main pattern in high-elevation sites, except during mid-summer. Persistence of the aquatic foraging tactics in the population may depend on a trade-off between costs and benefits. [less ▲]

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See detailSeasonal plasticity in the song control system - Multiple brain sites of steroid hormone action and the importance of variation in song behavior
Ball, Gregory F.; Auger, Catherine J.; Bernard, Daniel J. et al

in Annals of the New York Academy of Sciences (2004), 1016

Birdsong, in non-tropical species, is generally more common in spring and summer when males sing to attract mates and/or defend territories. Changes in the volumes of song control nuclei, such as HVC and ... [more ▼]

Birdsong, in non-tropical species, is generally more common in spring and summer when males sing to attract mates and/or defend territories. Changes in the volumes of song control nuclei, such as HVC and the robust nucleus of the arcopallium (RA), are observed seasonally. Long photoperiods in spring stimulate the recrudescence of the testes and the release of testosterone. Androgen receptors, and at times estrogen receptors, are present in HVC and RA as are co-factors that facilitate the transcriptional activity of these receptors. Thus testosterone can act directly to induce changes in nucleus volume. However, dissociations have been identified at times among long photoperiods, maximal concentrations of testosterone, large song control nuclei, and high rates of song. One explanation of these dissociations is that song behavior itself can influence neural plasticity in the song system. Testosterone can act via brain-derived neurotrophic factor (BDNF) that is also released in HVC as a result of song activity. Testosterone could enhance song nucleus volume indirectly by acting in the preoptic area, a region regulating sexual behaviors, including song, that connects to the song system through catecholaminergic cells. Seasonal neuroplasticity in the song system involves an interplay among seasonal state, testosterone action, and behavioral activity. [less ▲]

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See detailActualites therapeutiques 2003-2004.
Scheen, André ULg

in Revue Médicale de Liège (2004), 59(6), 385-402

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and its modalities of appropriate use in clinical practice will be emphasized. Both the efficacy and safety of these new drugs have been evaluated in randomised controlled trials according to the evidence-based-medicine criteria. Most of them are currently studied in order to further demonstrate their potential benefit on a long-term basis, in large cohort of patients and using hard clinical endpoints. [less ▲]

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See detailDes pratiques réflexives en formation initiale, pour une intégration optimale de la théorie et de la pratique
Vanhulle, Sabine; Deum, Mélanie ULg; Mattar, Catherine et al

in Caractères (2004), 15/2

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See detailGenomic structure, organisation, and promoter analysis of the bovine (Bos taurus) Mx1 gene
Gérardin; Baise, Etienne ULg; Pire, Grégory et al

in Gene (2004), 326

Some MX proteins are known to confer a specific resistance against a panel of single-stranded RNA viruses. Many diseases due to such viruses are known to affect cattle worldwide, raising the possibility ... [more ▼]

Some MX proteins are known to confer a specific resistance against a panel of single-stranded RNA viruses. Many diseases due to such viruses are known to affect cattle worldwide, raising the possibility that the identification of an antiviral isoform of a bovine MX protein would allow the implementation of genetic selection programs aimed at improving innate resistance of cattle. With this potential application in mind, the present study was designed to isolate the bovine Mx1 gene including its promoter region and to investigate its genomic organisation and promoter reactivity. The bovine Mx1 gene is made up of 15 exons. All exon-intron boundaries conformed to the consensus sequences. A PCR product that contained a approximately 1-kb, 5'-flanking region upstream from the putative transcription start site was sequenced. Unexpectedly, this DNA region did not contain TATA or CCAAT motifs. A computer scan of the region disclosed a series of putative binding sites for known cytokines and transcription factors. There was a GAAAN(1-2)GAAA(C/G) motif, typical of an interferon-sensitive responsive element, between -118 and -107 from the putative transcription start site. There were also a NF-kappaB, two interleukin-6 binding sites, two Sp1 sites and five GC-rich boxes. The region also contained 12 stretches of the GAAA type, as described in all IFN-inducible genes. Bovine Mx1 expression was assessed by Northern blotting and immunofluorescence in the Madin Darby bovine kidney cells (MDBK) cell line treated with several stimuli. In conclusion, the bovine Mx1 gene and promoter region share the major structural and functional characteristics displayed by their homologs described in the rainbow trout, chicken, mouse and man. [less ▲]

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See detailLe droit européen de l'environnement à l'heure de l'émission trading
Pâques, Michel ULg; Charneux, S.

in Les cahiers du Juriste (2004), 2

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See detailEffect of haemodialysis on acoustic shear wave propagation in the skin.
Uhoda, I.; Petite, Louicette ULg; Krzesinski, Jean-Marie ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2004), 209(2), 95-100

BACKGROUND: Diverse skin alterations may develop in patients under chronic haemodialysis. Among them, signs of premature photo-ageing have been described. AIM: To assess alterations in the physical ... [more ▼]

BACKGROUND: Diverse skin alterations may develop in patients under chronic haemodialysis. Among them, signs of premature photo-ageing have been described. AIM: To assess alterations in the physical properties of skin consistent with ageing effects and with cutaneous fluid exchanges during haemodialysis sessions. METHODS: In the first part of the study, 45 haemodialysed patients were compared to 45 age-, sex- and body-mass-index-matched healthy subjects. In the second part of the study, skin of 30 haemodialysed patients was assessed immediately before and after a haemodialysis session. The speed of ultrasound shear wave propagation was measured in each subject. Series of 16 multidirectional resonance running time measurements (RRTM) were performed on the forehead and/or the volar forearm. They were averaged for each subject. The corresponding intra-individual coefficients of variation were calculated as an estimate of the skin mechanical anisotropy. RESULTS: In both haemodialysed patients and their matched controls, RRTM values were significantly higher on the forearms than on the forehead. By contrast, no significant difference was found in RRTM values that could be ascribed to chronic haemodialysis. However, RRTM values were significantly increased as an immediate and probably transient effect of haemodialysis sessions. In healthy subjects, ageing was associated with increased RRTM values. CONCLUSION: Chronic haemodialysis does not appear to influence significantly the functional expression of the dermal ageing process. Subtle fluid movements occurring in the skin during haemodialysis sessions can be assessed by measuring non-invasively the speed of ultrasound shear wave propagation in the skin. [less ▲]

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See detailMixture model for inferring susceptibility to mastitis in dairy cattle: a procedure for likelihood-based inference
Gianola, D.; Odegard, J.; Heringstad, B. et al

in Genetics, Selection, Evolution (2004), 36(1, JAN-FEB), 3-27

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop ... [more ▼]

A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop criteria for genetic selection against mastitis, an important udder disease. Parameter estimation is by maximum likelihood or by an extension of restricted maximum likelihood. A Monte Carlo expectation- maximization algorithm is used for this purpose. The expectation step is carried out using Gibbs sampling, whereas the maximization step is deterministic. Ranking rules based on the conditional probability of membership in a putative group of uninfected animals, given the somatic cell information, are discussed. Several extensions of the model are suggested. [less ▲]

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See detailLe contrat de rivière Semois : de la qualité de l'eau au tourisme.
Pierre, M.; Rosillon, Françis ULg

in Espaces, tourisme et loisirs (2004), (213), 50-55

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See detailTumor invasion and matrix metalloproteinases
Polette, M.; Nawrocki-Raby, B.; Gilles, Christine ULg et al

in Critical Reviews in Oncology/Hematology (2004), 49(3), 179-86

Matrix metalloproteinases (MMPs) are proteolytic enzymes which play a major role in tumour invasion. They are mainly produced by host stromal cells in most carcinomas and their expression implies a close ... [more ▼]

Matrix metalloproteinases (MMPs) are proteolytic enzymes which play a major role in tumour invasion. They are mainly produced by host stromal cells in most carcinomas and their expression implies a close co-operation between tumour and stromal cells. Increasing data also demonstrate that, in association with a process of epithelial-to-mesenchymal transition, many MMPs can be expressed by tumour cell themselves. Their most well-known role is the degradation of extra-cellular matrix macromolecules which in turn may regulate tumour invasion in some conditions. This ECM degradation generates some matrikins which are also implicated in tumour invasion and angiogenesis. Moreover, MMPs are also implicated in the degradation of cell adhesion molecules and release and activation of growth factors. [less ▲]

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See detailLe cas clinique du mois. Purpura révélateur d'un rhumatisme articulaire aigu.
Fumal, I.; Henry, Frédérique ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(11), 630-2

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for ... [more ▼]

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for identifying the disease. [less ▲]

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See detailTreatment of osteoporosis with biphosphonates - Do compliance and persistence matter ?
Reginster, Jean-Yves ULg; LECART, Marie-Paule ULg

in Business briefing : Long-term Healthcare (2004), 5

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See detailCrystal structure of a dimeric oxidized form of human peroxiredoxin 5
Evrard, Christine ULg; Capron, Arnaud; Marchand, Cécile et al

in Journal of Molecular Biology (2004), 337

Peroxiredoxin 5 is the last discovered mammalian member of an ubiquitous family of peroxidases widely distributed among prokaryotes and eukaryotes. Mammalian peroxiredoxin 5 has been recently classified ... [more ▼]

Peroxiredoxin 5 is the last discovered mammalian member of an ubiquitous family of peroxidases widely distributed among prokaryotes and eukaryotes. Mammalian peroxiredoxin 5 has been recently classified as an atypical 2-Cys peroxiredoxin due to the presence of a conserved peroxidatic N-terminal cysteine (Cys47) and an unconserved resolving C-terminal cysteine residue (Cys151) forming an intramolecular disulfide intermediate in the oxidized enzyme. We have recently reported the crystal structure of human peroxiredoxin 5 in its reduced form. Here, a new crystal form of human peroxiredoxin 5 is described at 2.0 Ǻ resolution. The asymmetric unit contains three polypeptide chains. Surprisingly, beside two reduced chains, the third one is oxidized although the enzyme was crystallized under initial reducing conditions in presence of 1 mM 1,4-dithio-DL-threitol. The oxidized polypeptide chain forms an homodimer with a symmetry related one through intermolecular disulfide bonds between Cys47 and Cys151. The formation of these disulfide bonds is accompanied by the partial unwinding of the N-terminal parts of the a2 helix, which in the reduced form, contains the peroxidatic Cys47 and the α6 helix, which is sequentially close to the resolving residue Cys151. In each monomer of the oxidized chain, the C-terminal part including the α6 helix is completely reorganized and is isolated from the rest of the protein on an extended arm. In the oxidized dimer, the arm belonging to the first monomer now appears at the surface of the second subunit and vice versa. [less ▲]

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See detailGenetic characterization of the Indian cattle breeds, Ongole and Deoni (Bos indicus), using microsatellite markers - a preliminary study.
Metta, Muralidhar ULg; Kanginakudru, Sriramana; Gudiseva, Narasimharao et al

in BMC Genetics (2004), 5

BACKGROUND: Molecular characterization of cattle breeds is important for the prevention of germplasm erosion by cross breeding. The Indian zebu cattle have their significant role in evolution of present ... [more ▼]

BACKGROUND: Molecular characterization of cattle breeds is important for the prevention of germplasm erosion by cross breeding. The Indian zebu cattle have their significant role in evolution of present day cattle breeds and development of some of the exotic breeds. Microsatellites are the best available molecular tools for characterization of cattle breeds. The present study was carried out to characterize two Indian cattle breeds, Ongole and Deoni, using microsatellite markers. RESULTS: Using 5 di- and 5 tri-nucleotide repeat loci, 17 Ongole and 13 Deoni unrelated individuals were studied. Of the ten loci, eight revealed polymorphism in both the breeds. The di-nucleotide repeat loci were found to be more polymorphic (100%) than tri-nucleotide repeat loci (60%). A total of 39 polymorphic alleles were obtained at 4.5 alleles per locus in Ongole and 4.1 in Deoni. The average expected heterozygosity was 0.46 (+/-0.1) and 0.50 (+/-0.1) in Ongole and Deoni breeds, respectively. The PIC values of the polymorphic loci ranged from 0.15 to 0.79 in Ongole and 0.13 to 0.80 in Deoni breeds. Six Ongole specific and three Deoni specific alleles were identified. The two breeds showed a moderate genetic relationship between themselves with a FST value of 0.117 (P = 0.01). CONCLUSIONS: This preliminary study shows that microsatellite markers are useful in distinguishing the two zebu breeds namely, Ongole and Deoni. Further studies of other zebu breeds using many microsatellite loci with larger sample sizes can reveal the genetic relationships of Indian breeds. [less ▲]

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See detailInvisible Sketch Interface in Architectural Engineering, in Graphics Recognition, Recent Advanced and Perspectives
Leclercq, Pierre ULg

in Lecture Notes in Computer Science (2004), 3088

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See detailDiscriminative stimulus effects of ethanol: Lack of interaction with taurine
Quertemont, Etienne ULg; Grant, Kathleen A.

in Behavioural Pharmacology (2004), 15(7), 495-501

Recent microdialysis studies showed that ethanol administration increases the release of taurine in various rat brain regions, and it was suggested that this increase in extracellular concentrations of ... [more ▼]

Recent microdialysis studies showed that ethanol administration increases the release of taurine in various rat brain regions, and it was suggested that this increase in extracellular concentrations of taurine might mediate some of the neurochemical effects of ethanol. Previous drug discrimination studies showed that positive modulators of the GABA(A) receptor consistently substituted for ethanol discriminative stimulus effects. Since taurine is also believed to modulate GABA(A) receptor activity, this study addressed the hypothesis that taurine mediates the discriminative stimulus effects of ethanol due to GABA(A) activation. Male Long-Evans rats were trained to discriminate water from either 1 or 2 g/kg ethanol. In a first experiment, various taurine doses (0-500 mg/kg) were tested to investigate whether taurine substitutes for ethanol. In a second experiment, rats were pretreated with either 500 mg/kg taurine or an equivalent volume of saline before testing for ethanol discrimination with various ethanol doses (0-2.0 g/kg). The results showed that taurine does not substitute for ethanol at any tested doses. In addition, taurine pretreatments failed to modify the dose-response curve for ethanol discrimination. These results demonstrate that taurine is not directly involved in mediating the discriminative stimulus effects of ethanol. It is therefore very unlikely that the brain release of taurine observed after ethanol administration is implicated in the major pharmacological effects of ethanol, i.e. positive modulation of GABA(A) receptor, that mediate its discriminative stimulus effects. [less ▲]

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See detailLes entreprises sociales d’insertion dans l’Union Européenne : un aperçu général
Davister, Catherine; Defourny, Jacques ULg; Grégoire, Olivier

in RECMA – Revue Internationale de l'Economie Sociale (2004), 293

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See detailUltrasonography in early pregnancy diagnosis and measurements of fetal size in reindeer (Rangifer tarandus tarandus)
Vahtiala, S.; Sakkinen, H.; Dahl, E. et al

in Theriogenology (2004), 61(4), 785-795

Transrectal or transabdominal examinations of 13 pluriparous reindeer (Rangifer tarandus tarandus) by ultrasonography from the start of mating until week 20 of gestation were conducted to find out when ... [more ▼]

Transrectal or transabdominal examinations of 13 pluriparous reindeer (Rangifer tarandus tarandus) by ultrasonography from the start of mating until week 20 of gestation were conducted to find out when pregnancy could first be detected and to describe fetal development in early pregnancy. The examinations (n = 35 per animal) were performed with a 5 MHz linear transducer from 7th October until 1st January and with a 3 MHz sector transducer from that time until 24th February. Time of pregnancy diagnosis by ultrasonography, the first fetal heartbeat and measurements of crown-rump length, chest width and chest depth were recorded during the examinations. Pregnancy was diagnosed by transrectal ultrasonography between the weeks 3 and 7 of gestation. The accuracy of the pregnancy diagnosis, defined as the proportion of females correctly detected to be pregnant, was 15% at week 3, 46% at week 4, 77% at week 5, and 92% at week 6 of gestation. Fetal heartbeat was first detected between the weeks 5 and 8 of gestation. The first measurements of crown-rump length were made on week 3 of gestation, of chest width on week 4 and of chest depth on week 5 of gestation. Chest width and depth were detectable until the end of the study at week 20 of gestation. Transrectal ultrasonography is an efficient tool in early pregnancy diagnosis of reindeer. The fetal growth curves obtained by ultrasonography resembled those obtained in previous morphological studies. [less ▲]

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See detailCyclodextrins as a potential carrier in drug nebulization.
Evrard, Brigitte ULg; Bertholet, P.; Guéders, Maud ULg et al

in Journal of Controlled Release (2004), 96(3), 403-10

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. [less ▲]

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See detailDeux protocoles d’hyperimmunisation au moyen de vaccins marqués réduisent l’incidence de séroconversion envers l’herpèsvirus bovin 1 en cheptels laitiers : résultats d’une étude sur le terrain
Dispas, M.; Lemaire, Mylène; Speybroeck, N. et al

in Annales de Médecine Vétérinaire (2004), 148(1), 47-61

A 28 months long cohort study was organized in dairy herds in Belgium, to assess the efficacy of hyperimmunisation as a tool for the control of infectious bovine rhinotracheitis. Two protocols of ... [more ▼]

A 28 months long cohort study was organized in dairy herds in Belgium, to assess the efficacy of hyperimmunisation as a tool for the control of infectious bovine rhinotracheitis. Two protocols of hyperimmunisation in which glycoprotein-E deleted marker vaccines were repeatedly administered were compared to a positive control group in which the usual vaccination protocols were authorised. The two hyperimmunisation protocols differed in the primovaccination : the first group was treated with an attenuated vaccine firstly given intra-nasally then by intramuscular route whereas the second group was given an inactivated vaccine by subcutaneous injection. Afterwards, booster vaccinations were the same in both groups : an inactivated vaccine was administered by subcutaneous route every 6 months. In the control group, as a rule, part of the herd was vaccinated annually. For each group, 6 half-yearly reports specify : 1. the evolution of the population, categorized by birth half-year, 2. the incidence of seroconversion against gE in the cohorts and 3. the evolution of the gE seroprevalence. The survival curves of the hyperimmunised groups show a significantly higher proportion (P < 0,001) of animals remaining seronegative against glycoprotein- E compared to the positive control group. No significant difference was shown between the two protocols of hyperimmunisation. Both of them could then be used as tools for the control of infectious bovine rhinotracheitis. [less ▲]

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See detailEffects of an experimental Trypanosoma congolense infection on the reproductive performance of West African Dwarf goats.
Faye, Dethie; Sulon, Joseph ULg; Kane, Yaghouba et al

in Theriogenology (2004), 62(8), 1438-51

Thirty-six West African Dwarf (WAD) goats were used to assess the effects of an experimental Trypanosoma congolense infection on their reproductive system. Estrous cycles were synchronised and when ... [more ▼]

Thirty-six West African Dwarf (WAD) goats were used to assess the effects of an experimental Trypanosoma congolense infection on their reproductive system. Estrous cycles were synchronised and when confirmed pregnant (n = 31), the does were randomly allocated into control and trypanosome-infected groups. After infection, the animals were carefully observed till parturition. Trypanosome infection caused an increase of rectal temperature, a significant drop in PCV (infected: 23.3 +/- 0.3%; control: 28.5 +/- 0.4%; P < 0.0001) and abortions in 27.8% of the infected does. Kids born from infected does had a lower birth weight than kids born from control goats (0.9 +/- 0.1 kg versus 1.6 +/- 0.1 kg; P < 0.0001). Eight out of 13 kids (61.5%) that were born alive from infected does died during their first week of life. Plasma pregnancy-associated glycoprotein (PAG) and progesterone concentrations were lower in the infected animals than in the controls. In general, PAG concentration in does which aborted dropped before abortion. Our results revealed that artificial T. congolense infection affected reproductive performance of WAD goats with abortions, premature births and perinatal losses being observed. Neither transplacental transmission of T. congolense nor histopathological lesions of the placenta could be demonstrated. [less ▲]

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See detailExtended formulations for Gomory Corner polyhedra
Köppe, Matthias; Louveaux, Quentin ULg; Weismantel, Robert et al

in Discrete Optimization (2004), 1(2), 141-165

We present several types of extended formulations for integer programs, based on irreducible integer solutions to Gomory’s group relaxations. We present algorithmic schemes based on an iterative ... [more ▼]

We present several types of extended formulations for integer programs, based on irreducible integer solutions to Gomory’s group relaxations. We present algorithmic schemes based on an iterative reformulation technique using these extended formulations. We give computational results for benchmark problems, which illustrate the primal and dual effect of the reformulation. [less ▲]

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See detailLes modes alternatifs de règlement des différends: anges ou démons?
Caprasse, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2004)

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See detailImprovement of metal dispersion in Pd/SiO2 cogelled xerogel catalysts for 1,2-dichloroethane hydrodechlorination
Lambert, Stéphanie ULg; Polard, Jean-François; Pirard, Jean-Paul ULg et al

in Applied Catalysis B : Environmental (2004), 50

The study of the influence of synthesis operating variables (nature and concentration of complexing silane, palladium percentage, temperatures of gelling, aging and vacuum drying of xerogels, molar ratio ... [more ▼]

The study of the influence of synthesis operating variables (nature and concentration of complexing silane, palladium percentage, temperatures of gelling, aging and vacuum drying of xerogels, molar ratio between the complexing silane and palladium, molar concentration of ammonia solution, and use of tetramethylammonium hydroxide as base instead of NH3) allows improving metal dispersion in Pd/SiO2 cogelled xerogel catalysts. The use of 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) or 3-(2-aminoethylamino)propyltriethoxysilane (EDAES) to complex palladium in an ethanolic solution containing tetraethoxy si lane (TEOS) and an ammonia solution of 0.54 mol/l allows obtaining a Pd/SiO2 xerogel catalyst with a mean metal particle diameter of 2.4 nm located inside silica particles. Indeed, complexes Pd(EDA(E)S)(x)(n+) induce a nucleation mechanism because of their higher reactivity compared to the network-reagent (TEOS). Although metal particles are located inside the silica particles, their complete accessibility, via the micropore network, has been shown. 1,2-dichloroethane hydrodechlorination over Pd/SiO2 catalysts mainly produces ethane and the specific hydrodechlorination rate per gram of palladium increases proportionally with palladium dispersion. Hydrodechlorination over Pd/SiO2 cogelled xerogel catalysts is a structure insensitive reaction with regard to the ensemble size concept. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailXPS data analysis via Wavelets and Fourier Transform.
Charles, Catherine ULg; Rasson, Jean-Paul; Leclerc, Gervais

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailBacteremia after hematopoietic stem cell transplantation: incidence and predictive value of surveillance cultures.
Frere, Pascale ULg; Hermanne, J.-P.; Debouge, M.-H. et al

in Bone Marrow Transplantation (2004), 33(7), 745-9

We studied 622 transplants undertaken between 1982 and 2001 to: (1) determine the incidence, timing and etiology of bacteremias, and (2) examine the ability of routine surveillance cultures to predict ... [more ▼]

We studied 622 transplants undertaken between 1982 and 2001 to: (1) determine the incidence, timing and etiology of bacteremias, and (2) examine the ability of routine surveillance cultures to predict bacteremias. A total of 404 episodes (0.65 episode per patient) occurred in 248 patients, due to coagulase-negative staphylococci (n=171, 42%), Gram-negative bacteria (n=129, 32%), streptococci (n=48, 12%), other Gram-positive bacteria (n=33, 8%), anaerobes (n=9, 2%) and fungi (n=14, 3%). Bacteremias were more frequent in allogeneic (0.96 episode/patient) compared to autologous (0.44) transplants (P<0.0001). The overall incidence decreased from 0.92 episode/patient until 1990 to 0.66 in 1991-1996 and 0.55 in 1997-2001 (P<0.0001), but this was only observed in autologous transplants. Among them, 212 (53%) occurred before hospital discharge and 192 (47%) thereafter. This proportion was lower for coagulase-negative staphylococci, other Gram-positive bacteria and Gram-negative bacteria compared to other agents (P=0.001). In 50% of the cases, the agent responsible for the bacteremic episode was present in routine surveillance cultures previously. In conclusion: (1) bacteremias remain a frequent complication, particularly in allogeneic transplantation, even long after hospital discharge; (2) routine surveillance cultures can predict bacteremias in 50% of the cases, but the practical impact of this observation is limited in view of the costs. [less ▲]

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See detailSoup 'n Old Clothes : Frank Zappa’s Peristaltic Poetics
Delville, Michel ULg

in Oficina de poesia: Revista de palavra e da imagem (2004)

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See detailSerum melatonin and urinary 6-sulfatoxymelatonin in major depression.
Crasson, Marion ULg; Kjiri, Selwa; Colin, Anne et al

in Psychoneuroendocrinology (2004), 29

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