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See detailL'idiologue à raison : A propos du P. Cattaoui, recto, col. V = M. Chr. 372, col. VI
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (2003), LXXVIII(155-156), 217-220

Examination of the minutes of a hearing before the idios logos (M. Chr. 372; 22 November A.D. 136) in which the ownership of slaves left by a deceased soldier without heirs poses problems. The solution ... [more ▼]

Examination of the minutes of a hearing before the idios logos (M. Chr. 372; 22 November A.D. 136) in which the ownership of slaves left by a deceased soldier without heirs poses problems. The solution chosen by the idios logos rests on a sound logic and a fair application of the law.. [less ▲]

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See detailThe cutting edge of superabrasives quality control
Pirard, Eric ULg

in Industrial Diamond Review (2003), 03(3), 49-50

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See detailLa guerre et la médecine d'une culture de paix. 3- Synopsis des armes chimiques.
Pierard, Gérald ULg

in FALCO (2003), Janvier

A variety of chemical components can be used as warfare threats directly targeting humans. They can be classified according to their main biological effects as nerve agents, vesicants, lung damaging ... [more ▼]

A variety of chemical components can be used as warfare threats directly targeting humans. They can be classified according to their main biological effects as nerve agents, vesicants, lung damaging agents, cyanogen agents and incapacitants. Other chemical agents are water and food contaminants. Sill other less aggressive compounds are mainly used to control riots. Smokes, flame materials and herbicides belong to other classes of chemical agents of the warlike armamentum exhibiting a direct effect on man. [less ▲]

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See detailAn intervention study to enhance postoperative pain management.
Bardiau, Françoise ULg; Taviaux, Nicole F; Albert, Adelin ULg et al

in Anesthesia and Analgesia (2003), 96(1), 179-85

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery ... [more ▼]

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery departments were involved. In this study we sought to evaluate the results of a continuous quality improvement program by defining quality indicators and using quality tools. A quality program in accordance with current standards of acute pain treatment (multimodal) was worked out to enhance pain relief for all surgical inpatients. A survey of nurses' knowledge with regard to postoperative pain was conducted, and a visual analog scale (VAS) was introduced to assess pain intensity. Both nurses and physicians became familiar with evidence-based guidelines concerning postoperative pain. The entire process was monitored in three consecutive surveys and enrolled 2383 surgical inpatients. Pain indicators based on VAS and analgesic consumption were recorded during the first 72 postoperative hours. After a baseline survey about current practices of pain treatment, a nurse-based, anesthesiologist-supervised APS was implemented. The improvement in pain relief, expressed as VAS scores, was assessed in two further surveys. A quality manual was written and implemented. A major improvement in pain scores was observed after the APS inception (P < 0.001). IMPLICATIONS: The implementation of an acute pain service, including pain assessment by a visual analog scale, standard multimodal pain treatment, and continuous quality evaluation, improved postoperative pain relief. Establishing teams of surgeons, anesthesiologists, and nurses is the prerequisite for this improvement. [less ▲]

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See detailUpdate on GPIIb/IIIa antagonists
Hanson, Julien ULg; De Leval, X.; Kolh, Philippe ULg et al

in Expert Opinion on Therapeutic Patents (2003), 13

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See detailComment je traite ... les troubles de la magnésémie
Guillaume, Thierry; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2003), 58(7-8), 465-467

Because symptoms associated with hypomagnesia are highly aspecific, this ionic abnormality is rarely searched for although it could be present in as much as 20 % of the population. The mode of correction ... [more ▼]

Because symptoms associated with hypomagnesia are highly aspecific, this ionic abnormality is rarely searched for although it could be present in as much as 20 % of the population. The mode of correction (oral or intravenous) depends on the etiology, severity and clinical consequences of hypomagnesemia. Significant hypermagnesemia only occurs in the presence of renal insufficiency and/or acute excess administration, mainly by the intravenous route. If interruption of administration does not suffice, renal dialysis might become necessary to quickly correct the magnesemium serum levels. [less ▲]

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See detailAn Integrated Software for Scantling Optimization and Least Production Cost
Rigo, Philippe ULg

in Ship Technology Research = Schiffstechnik (2003)

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See detailUne approche par les compétences pour l’apprentissage des soins infirmiers. Analyse des pratiques des enseignants.
Dury, Cécile ULg

in Recherche en Soins Infirmiers (2003), 73(Juin), 4-40

The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non ... [more ▼]

The aims of this qualitative research is to understand how the teaching methods of nursing teachers inhance the student's competencies development. Eight nursing teachers were interviewed in a non-directive approach. The data were analysed with a qualitative method: "structural analysis method". The results showed that their methods are in majority in a transmissive and behavioral model; an inadequacy between teaching methods and pedagogical goals; an abivalent and unclear understanding of their role; a lack of coherence in the assesment methods. To conclude, various strategies are proposed on institutional and national levels to support the implementation of a competence-based approach in nursing training. [less ▲]

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See detailLe medicament du mois. Gliclazide a liberation modifiee (Uni Diamicron).
Scheen, André ULg

in Revue Médicale de Liège (2003), 58(10), 641-5

Gliclazide modified release that has been recently launched by Servier (Uni Diamicron 30 mg) is a new formulation of gliclazide to be given once daily. The original hydrophilic matrix improves the ... [more ▼]

Gliclazide modified release that has been recently launched by Servier (Uni Diamicron 30 mg) is a new formulation of gliclazide to be given once daily. The original hydrophilic matrix improves the biodisponsibility of gliclazide and allows a progressive release of the drug that better parallels the 24-hour glycaemic profile of patients with type 2 diabetes mellitus. Such characteristics may explain the rather low risk of hypoglycaemic episodes and the morning administration should contribute to improve patient's compliance. As the common formulation of gliclazide, the modified release formulation is indicated in the treatment of type 2 diabetes, in adult subjects, when diet, exercise and weight loss are insufficient to restore an adequate metabolic control. It may be used alone or in combination with metformin, glitazones, acarbose or insulin, with the same general principles of use as for the classical formulation of gliclazide. [less ▲]

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See detailLa problématique de la résistance des pneumocoques aux antibiotiques
Marchal, Valérie; Melin, Pierrette ULg; Hayette, Marie-Pierre ULg et al

in Revue Médicale de Liège (2003), 58(11), 675-680

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and it is also a common cause of sinusitis, otitis media, bacteremia and meningitis. The increasing resistance to ... [more ▼]

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and it is also a common cause of sinusitis, otitis media, bacteremia and meningitis. The increasing resistance to antimicrobial agents, now endemic in many countries, reflects an uncontrolled use of antibiotics. A good antibiotics policy and vaccination are at the moment the only way to control efficaciously the increasing antibiotic resistance of Streptococcus pneumoniae [less ▲]

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See detailInositol 1,3,4,5-tetrakisphosphate is essential for normal T lymphocyte development
Pouillon, V.; Hascakova-Bartova, R.; Pajak, B. et al

in Nature Immunology (2003), 4

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4 ... [more ▼]

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4) is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5)P(3) amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development [less ▲]

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See detailJean Michel-Bonvin : Figures de sociologues. Introduction à l'epistémologie sociologique
Jacquemain, Marc ULg

in Schweizerische Zeitschrift für Soziologie = Revue Suisse de Sociologie (2003), 29

Jean-Michel Bonvin introduces the reader to the sociological method through the study of eight classical sociologists throught the 19th and 20th centurites : Comte, Tocqueville, Marx, Durkheim, Weber ... [more ▼]

Jean-Michel Bonvin introduces the reader to the sociological method through the study of eight classical sociologists throught the 19th and 20th centurites : Comte, Tocqueville, Marx, Durkheim, Weber, Simmel, Goffman and Parsons [less ▲]

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See detailChance in biology – Using probability to explore nature (M. Denny, S. Gaines).
Bogaert, Jan ULg

in Acta Biotheoretica (2003), 51(1), 55-57

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See detailQuantification of angiogenesis on the rat aortic ring assay.
Blacher, Silvia ULg; Devy, L.; Noël, Agnès ULg et al

in Image Analysis and Stereology (2003), 22

Image analysis is used to quantify angiogenesis on the rat aortic ring model. This technique allows to determine: (1) the aortic ring area and factor shape; (2) the number of microvessels, the total ... [more ▼]

Image analysis is used to quantify angiogenesis on the rat aortic ring model. This technique allows to determine: (1) the aortic ring area and factor shape; (2) the number of microvessels, the total number of branching, the maximal microvessel length and the number of microvessels in function of the distance to the aortic ring; (3) the total number of isolated fibroblast-like cells and the number of fibroblast-like cells in function of the distance to the aortic ring. We show that this method is suitable to quantify spontaneous angiogenesis as well as to analyse a complex microvascular network induced by vascular endothelial growth factor (VEGF). [less ▲]

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See detailNombres et jeux enfantins
Lempereur, Françoise ULg

in Enquêtes du Musée de la Vie Wallonne (2003), XX

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ... [more ▼]

Children learn to count at school and also by singing and playing traditional games. This paper goes through the traditional Walloon repertory and shows how it fits the childish rhythmics defined by ethnomusicologist Constantin Brailoiu [less ▲]

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See detailQu'est-ce qu'une maladie émergente?
Toma, B.; Thiry, Etienne ULg

in Epidémiologie et Santé Animale (2003), 44

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See detailIrritation cutanee et vitesse de propagation d'ondes ultrasonores.
Uhoda, Emmanuelle ULg; Pierard, Gérald ULg

in International Journal of Cosmetic Science (2003), 25(1-2), 31-5

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief ... [more ▼]

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief showing increased roughness, dehydration and erratic desquamation. Several instrumental methods can indirectly assess the issues of cutaneous irritation on human stratum corneum. The aim of the present study was to measure the speed of propagation of ultrasound shear waves in the skin irritated by anionic surfactants. The study was performed in 25 healthy subjects of both sexes. Occlusive patches of a 10% solution of anionic surfactants were applied to a forearm of each volunteer. The other forearm served as an untreated control site. Patches remained in place for 24 h. Three hours later, another patch was placed again for 21 h. Resonance running time measurements (RRTM) of the ultrasound shear wave were performed using a Reviscometer((R)) RVM 600. Measurements were performed at entry in the study and 2 days after removing the second patch. Desquamative xerosis was obvious at the sites patched with the surfactant solution. RRTM values were significantly (P < 0.0001) lower than those at the control site. Hence, the speed of propagation of ultrasound shear waves was shown to be increased at an irritated site compared to an intact site. In conclusion, this study shows that the propagation speed of ultrasounds is influenced by the skin surface nature, being considerably increased in skin altered by surfactants. [less ▲]

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See detailComment j'explore ... la controverse a propos de la place de l'hyperglycemie provoquee par voie orale en clinique.
Luyckx, Françoise ULg; Scheen, André ULg

in Revue Médicale de Liège (2003), 58(11), 701-5

The oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes or impaired glucose tolerance. However, since 1997, OGTT is not considered anymore ... [more ▼]

The oral glucose tolerance test (OGTT) has been widely used for the diagnosis of diabetes mellitus, gestational diabetes or impaired glucose tolerance. However, since 1997, OGTT is not considered anymore as the first choice test for the diagnosis of diabetes mellitus or impaired glucose tolerance, being replaced by fasting glycaemia. Numerous studies, however, stressed the discrepancies between these two diagnostic approaches, so that OGTT still has defenders as a useful tool to diagnose diabetes. Besides, emphasis has been recently put on both postprandial hyperglycaemia, considered as a major cardiovascular risk factor, and impaired glucose tolerance as a predictor of progression toward overt type 2 diabetes, two parameters well addressed by the OGTT. Thus, even if the place to be reserved to the OGTT is controversial, in our opinion, this test still has a place in clinical biology. [less ▲]

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See detailLe positionnement multidimensionnel : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (2003), (1), 1-32

This note describes some multidimensional scaling methods for two-way, one-mode tables and for three-way, two-mode tables. The methods are illustrated by an example processed by PROC MDS of SAS software.

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See detailMesure de l'effet de l'hyperimmunisation pour le contrôle de la rhinotrachéite infectieuse bovine dans les troupeaux laitiers en Belgique : analyse de survie
Dispas, Marc; Kerkhofs, Pierre; Thiry, Etienne ULg

in Epidémiologie et Santé Animale (2003), 44

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See detailHistometric assessment of psoriatic plaques treated by vitamin D3 derivatives.
Uhoda, Isabelle; Quatresooz, Pascale ULg; Hermanns-Lê, Trinh ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 366-9

BACKGROUND: Psoriasis is an immunogenetic disorder. Factor XIIIa+ dermal dendrocytes (DD) are part of the pathobiological changes in the plaque type of the disease. OBJECTIVE: The present study aimed at ... [more ▼]

BACKGROUND: Psoriasis is an immunogenetic disorder. Factor XIIIa+ dermal dendrocytes (DD) are part of the pathobiological changes in the plaque type of the disease. OBJECTIVE: The present study aimed at comparing the effect of 3 vitamin D(3) derivatives on the epidermis, microvasculature and DD in psoriasis. METHOD: Twenty men suffering from chronic plaques of psoriasis on the trunk were enrolled in this study. They applied twice a day for 3 weeks calcipotriol, tacalcitol and calcitriol, each to one plaque. Another similar lesion received petrolatum as a placebo treatment. Skin biopsies were taken at entry and at completion of the 3-week treatment phase. Immunohistochemistry was performed using the lectin of Ulex europaeus and an antibody to factor XIIIa. Computerized image analysis served to measure the stratum Malpighii area, the microvasculature area and the DD numerical density in the papillary dermis. RESULTS: At entry in the study, the 4 test sites were indistinguishable with regard to the stratum Malpighii area, the papillary microvasculature area and the papillary DD density. The 3 histometric parameters appeared correlated with each other. At completion of the 3-week treatment phase, the 3 vitamin D derivatives had decreased the size of the stratum Malpighii. In addition, calcitriol had also reduced the DD density in the papillary dermis. No other significant changes were yielded. CONCLUSION: As assessed by histometry, the psoriatic epidermis responded to a short treatment using the 3 vitamin D derivatives. The better result compared to the control site was achieved by calcitriol. DD appeared to be most controlled by the same drug. The microvasculature did not appear to be decreased at the 3-week time point in treatment. [less ▲]

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See detailVitamine E : état des connaissances chez les carnivores domestiques.I. Chimie, sources alimentaires et dosage
Cuvelier, Christine ULg; Dotreppe, Olivier ULg; Diez, Marianne ULg et al

in Annales de Médecine Vétérinaire (2003), 147

Vitamin E is a part of the defence mechanism for the inactivation of free radicals and is therefore implicated in the oxidative stress. Chemistry of vitamin E is relatively complex. Vitamin E includes 2 ... [more ▼]

Vitamin E is a part of the defence mechanism for the inactivation of free radicals and is therefore implicated in the oxidative stress. Chemistry of vitamin E is relatively complex. Vitamin E includes 2 large groups of molecules, tocopherols and tocotrienols, each including 32 stereoisomers. Vitamin E is synthesized in plants, algae, and moulds but not in animals. The greatest quantities of vitamin E are found in cereals and vegetable oils. Vitamin E analyses are difficult to perform. After treatment of a sample with an organic solvent such as ethanol, vitamin E is usually extracted into hexane. Identification and quantification are carried out mainly by chromatography such as normal-phase liquid chromatography and reversed-phase liquid chromatography. [less ▲]

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See detailA low rate of trisomy 21 in twin-pregnancies: A cytogenetics retrospective study of 278 cases
Jamar, Mauricette ULg; Lemarchal, C.; Koulischer, Lucien ULg et al

in Genetic Counseling (2003), 14(4), 395-400

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See detailPrevention cardio-vasculaire chez le patient diabetique de type 2.
Paquot, Nicolas ULg; Scheen, André ULg

in Revue Médicale de Liège (2003), 58(5), 271-4

It is estimated that 80% of individuals with type 2 diabetes die of cardiovascular diseases. Several factors account for the accelerated atherosclerosis present in diabetic patients. These include ... [more ▼]

It is estimated that 80% of individuals with type 2 diabetes die of cardiovascular diseases. Several factors account for the accelerated atherosclerosis present in diabetic patients. These include hyperglycaemia, dyslipidaemia, hypertension and prothrombotic state. Hypoglycaemic agents, statin or fibrates that improve dyslipidaemia, anti-hypertensive agents, aspirin and healthy lifestyle can modify these factors and have been shown to reduce morbidity and mortality caused by coronary heart disease in diabetic patients. It was recently demonstrated that a multifactorial intervention on modifiable risk factors of cardiovascular disease in type 2 diabetic patients dramatically reduces the incidence of cardiovascular events. Thus, an intensified intervention aimed at multiple risk factors should be recommended in patients with type 2 diabetes. [less ▲]

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See detailL'interprétation des clauses d'une police d'assurance en cas de doute
Paris, Catherine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailShortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups
Bosset, J. F.; Roelofsen, F.; Morgan, D. A. L. et al

in European Journal of Cancer (2003), 39

Abstract The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined radiochemotherapy is the standard treatment for locally advanced anal ... [more ▼]

Abstract The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined radiochemotherapy is the standard treatment for locally advanced anal cancer. This EORTC phase II study (#22953) tests the feasibility of reducing the gap between sequences to 2 weeks, to deliver Mitomycin C (MMC) in each radiotherapy sequence and 5-FU continuously during the treatment. The first sequence consisted of 36 Gy over 4 weeks. 5-FU 200 mg/m2/days 1–26, MMC 10 mg/m2/day 1 gap 16 days. Then a second sequence of 23.4 Gy over 17 days, 5-FU 200 mg/m2/days 1–17 and, MMC 10 mg/m2/day 1 was given. 43 patients with a World Health Organization (WHO) status of 0 (n=27) or 1 (n=16) and with T2-T4, N0-3 tumours were included. Compliance with the planned treatment, doses and duration was 93%. The complete response rate was 90.7%. Grade 3 toxicities of 28, 12 and 2% were observed for skin, diarrhoea and haematological toxicities, respectively. The 3-year estimated rates for trials 22861 and 22953 are: 68 and 88% for local control; 72 and 81% for colostomy-free interval, 62 and 84% for severe late toxicity-free interval, and 70 and 81% for survival, respectively. The 22953 scheme is feasible and the results are promising. This is now considered as the new standard scheme by the EORTC. [less ▲]

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See detailPrevention of cardiovascular disease: plea for a rationale use of diet and lipid-lowering drugs.
Scheen, André ULg

in Acta Clinica Belgica (2003), 58(3), 149-51

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See detailThe treatment of sporadic versus MEN1-related pituitary adenomas.
Beckers, Albert ULg; Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Internal Medicine (2003), 253(6), 599-605

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single ... [more ▼]

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single or a combination of three different methods: surgery, medication and radiotherapy. The rationale for deciding the treatment are many but include the aggressiveness of the tumour. The aetiologies of sporadic pituitary adenomas are not fully understood. However, several causes have been identified resulting in specific familial phenotypes like multiple endocrine neoplasia type I (MEN1). MEN1 is related to mutations in the MEN1 gene, a tumour suppressor gene localized on chromosome 11q13 and which encodes menin, a 610 amino acid protein. During the last years, an evidence progressively emerged that MEN1-related adenomas were more aggressive and less responsive to therapy than their sporadic counterparts. In this article, we review the differences between sporadic and MEN1-related adenomas and suggest specific ways of treatment and follow-up for MEN1-related tumours. [less ▲]

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See detailCurrent management strategies for coexisting diabetes mellitus and obesity.
Scheen, André ULg

in Drugs (2003), 63(12), 1165-84

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular risk factors associated with insulin resistance in obese individuals with type 2 diabetes. Therapeutic strategies for the obese diabetic patient include: (i) promoting weight loss, through lifestyle modifications (low-calorie diet and exercise) and antiobesity drugs (orlistat, sibutramine, etc.); (ii) improving blood glucose control, through agents decreasing insulin resistance (metformin or thiazolidinediones, e.g. pioglitazone and rosiglitazone) or insulin needs (alpha-glucosidase inhibitors, e.g. acarbose) in preference to agents stimulating defective insulin secretion (sulphonylureas, meglitinide analogues); and (iii) treating common associated risk factors, such as arterial hypertension and dyslipidaemias, to improve cardiovascular prognosis. Whenever insulin is required by the obese diabetic patient after failure to respond to oral drugs, it should be preferably prescribed in combination with an oral agent, more particularly metformin or acarbose, or possibly a thiazolidinedione. When morbid obesity is present, both restoring a good glycaemic control and correcting associated risk factors can only be obtained through a marked and sustained weight loss. This objective justifies more aggressive weight reduction programmes, including very-low-calorie diets and bariatric surgery, but only within a multidisciplinary approach and long-term strategy. [less ▲]

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See detailComparaison empirique des estimateurs des taux d'erreur en analyse discriminante
Glele Kakai, R.; Piraux, F.; Fonton, N. H. et al

in Revue de Statistique Appliquée (2003), LI(3), 61-74

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi ... [more ▼]

Monte Carlo experiments are performed to compare twenty estimators or error rates in discriminant analysis in the case of two populations and linear classification rule. Several distributions (normal, chi-square and beta) have been considered. Estimators eOS (for actual and expected error rate) and eB (for optimal error rate) are the best, except for distributions very different from normal distributions. The e632 estimator is the best non parametric estimator. This estimator is better than parmetric estimators for distributions very different from normal distributions. [less ▲]

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See detailIs there a role for alpha-glucosidase inhibitors in the prevention of type 2 diabetes mellitus?
Scheen, André ULg

in Drugs (2003), 63(10), 933-51

Type 2 diabetes mellitus is a major health problem associated with excess morbidity and mortality. As the prevalence of this metabolic disorder is rapidly increasing and current treatment fails to ... [more ▼]

Type 2 diabetes mellitus is a major health problem associated with excess morbidity and mortality. As the prevalence of this metabolic disorder is rapidly increasing and current treatment fails to stabilise the disease in most patients, prevention should be considered as a key objective in the near future. People who develop type 2 diabetes pass through a phase of impaired glucose tolerance (IGT). Defects in the action and/or secretion of insulin are the two major abnormalities leading to development of glucose intolerance. Any intervention in the impaired glucose tolerance phase that reduces resistance to insulin or protects the beta-cells, or both, should prevent or delay progression to diabetes.Acarbose, miglitol and voglibose act by competitively inhibiting the alpha-glucosidases, a group of key intestinal enzymes involved in the digestion of carbohydrates. They decrease both postprandial hyperglycaemia and hyperinsulinaemia, and thereby may improve sensitivity to insulin and release the stress on beta-cells. These compounds do not induce hypoglycaemia and have a good safety profile, although gastrointestinal adverse effects may limit long-term compliance to therapy.The recent placebo-controlled prospective STOP-noninsulin-dependent diabetes mellitus (STOP-NIDDM) trial demonstrated that acarbose 100mg three times daily reduces the risk of developing type 2 diabetes in patients with IGT (relative risk reduction of 25% after a mean follow-up of 3.3 years). The 6-year Early Diabetes Intervention Trial (EDIT), comparing the effect of acarbose 50mg three times daily to that of metformin, showed a trend to a positive effect of acarbose compared with placebo, in a mid-term 3-year analysis, which should be confirmed in the final analysis.To our knowledge, no such prevention intervention trials have been or are currently being performed with miglitol or voglibose. In conclusion, because of its absence of toxicity and its particular mechanism of action on gastrointestinal tract and indirect consequences on both insulin action and beta-cell function, acarbose may be used to prevent type 2 diabetes. If the ongoing EDIT trial confirms the positive results of the recent STOP-NIDDM trial, acarbose could be used, either as an alternative or in addition to changes in lifestyle, to delay development of diabetes in patients with IGT. However, the best dosage of acarbose for this specific indication remains to be specified, especially when all three important parameters, efficacy, tolerance and cost, are taken into consideration. [less ▲]

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See detailJL 13, an atypical antipsychotic: A preclinical review
Ellenbroek, B. A.; Liégeois, Jean-François ULg

in Cns Drug Reviews (2003), 9(1, Spring), 41-56

The extensive pharmacological evaluation of JL 13 as an atypical antipsychotic drug has revealed a close similarity to clozapine, however with some major advantages. JL 13 was characterized as a weak D-2 ... [more ▼]

The extensive pharmacological evaluation of JL 13 as an atypical antipsychotic drug has revealed a close similarity to clozapine, however with some major advantages. JL 13 was characterized as a weak D-2 antagonist, both in vitro and in vivo, with a strong affinity for the D-4 and the 5-HT2A receptors. It has no affinity for the 5-HT2C receptor. In vivo microdialysis experiments in rat showed that JL 13, like clozapine, preferentially increased extracellular dopamine concentrations in the prefrontal cortex compared to nucleus accumbens or striatum. Behavioral studies showed that JL 13, like clozapine, has the profile of an atypical antipsychotic. Thus, JL 13 did not antagonize apomorphine-induced stereotypy nor did it produce catalepsy, but it antagonized apomorphine-induced climbing in rodents. It was inactive against d-amphetamine-induced stereotypy but antagonized d-amphetamine-induced hyperactivity in the mouse. Likewise, in the paw test, it was more effective in prolonging hindlimb retraction time than prolonging forelimb retraction time. Like other antipsychotic drugs, JL 13 reversed the apomorphine- and amphetamine-induced disruption of prepulse inhibition. In a complex temporal regulation schedule in the dog, JL 13 showed a high resemblance with clozapine without inducing sialorrhea, palpebral ptosis or any significant motor side effects. In rats and squirrel monkeys JL 13 induced a high degree of generalization (70%) to clozapine. Regarding behavioral toxicology, JL 13 did not produce dystonia or Parkinsonian symptoms in haloperidol-sensitized monkeys. After acute administration, again like clozapine, JL 13 induced only a transient increase in circulating prolactin. Last but not the least, regarding a possible hematological toxicity, unlike clozapine, JL 13 did not present sensitivity to peroxidase-induced oxidation. Moreover, its electrooxidation potential was close to that of loxapine and far from that of clozapine. Taking all these preclinical data into account, it appears that JL 13 is a promising atypical antipsychotic drug. [less ▲]

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See detailType I collagen triplet duplication mutation in lethal osteogenesis imperfecta shifts register of alpha chains throughout the helix and disrupts incorporation of mutant helices into fibrils and extracellular matrix.
Cabral, Wayne A; Mertts, Marianna V; Makareeva, Elena et al

in Journal of Biological Chemistry (2003), 278(12), 10006-12

The majority of collagen mutations causing osteogenesis imperfecta (OI) are glycine substitutions that disrupt formation of the triple helix. A rare type of collagen mutation consists of a duplication or ... [more ▼]

The majority of collagen mutations causing osteogenesis imperfecta (OI) are glycine substitutions that disrupt formation of the triple helix. A rare type of collagen mutation consists of a duplication or deletion of one or two Gly-X-Y triplets. These mutations shift the register of collagen chains with respect to each other in the helix but do not interrupt the triplet sequence, yet they have severe clinical consequences. We investigated the effect of shifting the register of the collagen helix by a single Gly-X-Y triplet on collagen assembly, stability, and incorporation into fibrils and matrix. These studies utilized a triplet duplication in COL1A1 exon 44 that occurred in the cDNA and gDNA of two siblings with lethal OI. The normal allele encodes three identical Gly-Ala-Hyp triplets at aa 868-876, whereas the mutant allele encodes four. The register shift delays helix formation, causing overmodification. Differential scanning calorimetry yielded a decrease in T(m) of 2 degrees C for helices with one mutant chain and a 6 degrees C decrease in helices with two mutant chains. An in vitro binary co-processing assay of N-proteinase cleavage demonstrated that procollagen with the triplet duplication has slower N-propeptide cleavage than in normal controls or procollagen with proalpha1(I) G832S, G898S, or G997S substitutions, showing that the register shift persists through the entire helix. The register shift disrupts incorporation of mutant collagen into fibrils and matrix. Proband fibrils formed inefficiently in vitro and contained only normal helices and helices with a single mutant chain. Helices with two mutant chains and a significant portion of helices with one mutant chain did not form fibrils. In matrix deposited by proband fibroblasts, mutant chains were abundant in the immaturely cross-linked fraction but constituted a minor fraction of maturely cross-linked chains. The profound effects of shifting the collagen triplet register on chain interactions in the helix and on fibril formation correlate with the severe clinical consequences. [less ▲]

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See detailThe frame problem in cognitive modeling
Anselme, Patrick ULg

in Cognitive Science Quarterly (2003), 3(3), 329-350

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See detailFinancement du terrorisme
Dantinne, Michaël ULg; Seron, Vincent ULg

in Revue de Droit Pénal et de Criminologie (2003), (6), 840-875

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See detailModeling of Thin Insulating Layers with Dual 3-D Magnetodynamic Formulations
Dular, Patrick ULg; Geuzaine, Christophe ULg

in IEEE Transactions on Magnetics (2003), 39(3), 1139--1142

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See detailEu10Mn6Sb13: A new ternary rare-earth transition-metal
Holm, A. P.; Park, S. M.; Condron, C. L. et al

in Inorganic Chemistry (2003), 42(15), 4660-4667

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 ... [more ▼]

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 crystallizes in the monoclinic space group C2/m with a = 15.1791(6) Angstrom, b = 19.1919(7) Angstrom, c = 12.2679(4) Angstrom, beta = 108.078(1)degrees, Z = 4 (R1 = 0.0410, wR2 = 0.0920), and T = 90(2) K. The structure of Eu10Mn6Sb13 is composed of double layers of Mn-centered tetrahedra separated by Eu2+ cations. The double layers are composed of edge- and corner-sharing Mn-centered tetrahedra which form cavities occupied by Eu2+ cations and [Sb-2](4-) dumbbells. Linear [Sb-3](5-) trimers bridging two tetrahedra across the cavity are also present. Bulk susceptibility data indicate paramagnetic behavior with a ferromagnetic component present below 60 K. Temperature-dependent electrical resistivity measurements show semiconducting behavior above 60 K (E-a = 0.115(2) eV), a large and unusually sharp maximum in the resistivity at similar to40 K, and metallic behavior below 40 K. Eu-151 Mossbauer spectra confirm that the europium is divalent with an average isomer shift of -11.2(1) mm/s at 100 K; the spectra obtained below 40 K reveal magnetic ordering of six of the seven europium sublattices and, at 4.2 K, complete ordering of the seven europium sublattices. [less ▲]

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See detailInduction et synchronisation de l'oestrus par la PGF2alpha
Hanzen, Christian ULg; Boudry, B.; Drion, Pierre ULg

in Point Vétérinaire (2003), 34(236), 22-23

Hormonal management of reproduction uses treatments that regulate both luteal activity and follicular growth to achieve expulsion in the shortest period of an oocyte capable of being fertilised. Therefore ... [more ▼]

Hormonal management of reproduction uses treatments that regulate both luteal activity and follicular growth to achieve expulsion in the shortest period of an oocyte capable of being fertilised. Therefore, PgF2alpha has been the object of numerous trials either as sin e or repeated injections, alone or in association with other hormones such as gonadorelin. Systematic insemination is more difficult after a single injection because return to ea is variable. A single injection is better for the physiology of follicular growth than the corpus luteum. Use of a double injection of PgF2alpha improves the degree of synchronisation but doesn't affect the ovulation rate. [less ▲]

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See detailModelling eutrophication in mesotidal and macrotidal estuaries. The role of intertidal seaweeds.
Alvera Azcarate, Aïda ULg; Ferreira, Joao; Nunes, Joao

in Estuarine Coastal & Shelf Science (2003), 57

The role of intertidal seaweeds in the primary production of mesotidal and macrotidal estuaries has been examined by means of a model, applied to the Tagus Estuary (Portugal). Special attention was paid ... [more ▼]

The role of intertidal seaweeds in the primary production of mesotidal and macrotidal estuaries has been examined by means of a model, applied to the Tagus Estuary (Portugal). Special attention was paid to the description of the underwater light climate in intertidal areas, and to the importance of the formation of tidal pools. Two approaches were compared for the simulation of suspended particulate matter (SPM) in the pool areas, using three algal species. The use of an erosion–deposition approach to simulate the distribution of SPM in tidal pools gives an increase in net primary productivity per unit area of between 130 and 1300%, when compared to the more conventional approach where the suspended matter in the overlying water in intertidal areas is considered identical to that in the channels. The upscaled erosion–deposition model was applied to tidal pool areas and combined with the more conventional model for other intertidal areas. Results show that annual carbon fixation by intertidal seaweeds in the estuary exceeds 13,500 t C yr−1, and accounts for 21% of the total carbon fixed by all primary producers. The corresponding nitrogen removal by seaweeds corresponds to the annual nutrient loading of a population of 490,000 inhabitants. [less ▲]

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See detailEffets du protocole GPG sur l’activité ovarienne
Hanzen, Christian ULg; Boudry, B.; Drion, Pierre ULg

in Point Vétérinaire (2003), 34(237), 26-30

The GPG protocol or OvSynch includes an injection of GnRH and followed seven days later by an injection of PgF(2alpha), which is preceded forty-eight hours earlier by a second injection of GnRH. The ... [more ▼]

The GPG protocol or OvSynch includes an injection of GnRH and followed seven days later by an injection of PgF(2alpha), which is preceded forty-eight hours earlier by a second injection of GnRH. The effects of GnRH on follicular tissue are either ovulation or luteinization depending at which stage of the cycle the cow is injected i.e. metoestrus, dioestrus or end of dioestrus. Observation of one or the other effect suggests a close association between the stage of follicular development, the function of the follicular tissue present and also the concentration of progesterone. [less ▲]

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See detailSuivi de la végétation en zone sèche par des produits d‘information dérivés de l‘imagerie spatiale
Crépeau, Christian; Bennouna, Taoufiq; Bicheron, Patrice et al

in Science et changements planétaires / Sécheresse (2003), 14(1), 56-57

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See detailOptimisation du protocole GPG
Hanzen, Christian ULg; Boudry, B.

in Point Vétérinaire (2003), 34(240), 44-46

Les facteurs susceptibles d’influencer les performances de reproduction permises par le protocole GPG sont multiples. L’apparition de l’oestrus et sa durée, la fréquence de l’ovulation, la croissance ... [more ▼]

Les facteurs susceptibles d’influencer les performances de reproduction permises par le protocole GPG sont multiples. L’apparition de l’oestrus et sa durée, la fréquence de l’ovulation, la croissance folliculaire, tout comme la progestéronémie, sont susceptibles d’être influencés par le stade du cycle auquel le protocole est mis en place. Le taux de gestation est d’autant plus élevé que la proportion d’animaux en anoestrus dans le troupeau est faible. Ceci explique sans doute en partie pourquoi la fertilité se trouve améliorée lorsque l’insémination suivant le traitement est effectuée après le 75e jour de lactation. De même, des résultats préliminaires confirment l’application potentielle du protocole au traitement des kystes ovariens. [less ▲]

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See detailInfluence of response factors on determining equilibrium association constants of non-covalent complexes by electrospray ionization mass spectrometry
Gabelica, Valérie ULg; Galic, Nives; Rosu, Frédéric ULg et al

in Journal of Mass Spectrometry [=JMS] (2003), 38(5), 491-501

A method for determining the equilibrium association constant of a complexation reaction A + B <=> AB by electrospray ionization mass spectrometry is described. The method consists in measuring the ... [more ▼]

A method for determining the equilibrium association constant of a complexation reaction A + B <=> AB by electrospray ionization mass spectrometry is described. The method consists in measuring the relative intensities of the peaks corresponding to A and to AB in equimolar A–B solutions at different concentrations C0. The results are fitted by a non-linear least-squares procedure, with the two variable parameters being the equilibrium association constant Ka and a factor R, defined by I(AB)/I.A/ = R× [AB]/[A]. The factor R is the ratio between the response factors of AB and A, and corrects for the relative electrospray responses of the complex and the free substrate A, mass discrimination of instrumental origin and/or moderate in-source dissociation. The method is illustrated with the following two systems: complexes between a double-stranded 12-base pair oligonucleotide and minor groove binders, and cyclodextrin complexeswith a,!-dicarboxylic acids. For the oligonucleotide complexes, it is found that the response of the complex is not dramatically different to the response of the free oligonucleotide duplex, as the double helix conformation is disturbed by the drug only to a minor extent. In the case of cyclodextrin complexes, these complexes were found to have a much higher response than free cyclodextrin. This may be due to the fact that cyclodextrin is neutral in solution, whereas the complex is charged, but it can also stem from the fact that a significant proportion of the complex is in a non-inclusion geometry. The present method requires the exact determination of the concentrations of the reactants and is applicable to 1 : 1 complexes. [less ▲]

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See detailSylviculture et qualité du bois de l'épicéa en Région wallonne
Hebert, Jacques ULg; Herman, Marc; Jourez, Benoît ULg

in Forêt Wallonne (2003), 62

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See detailTraitement de l'hypertension dans le syndrome métabolique et la néphropathie
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (2003), 2

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See detailProstaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells.
Gosset, Philippe; Bureau, Fabrice ULg; Angeli, Veronique et al

in Journal of Immunology (2003), 170(10), 4943-52

Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2 ... [more ▼]

Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2) are in part effected through two plasma membrane G protein-coupled receptors: the D prostanoid (DP) receptor and the chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTH2). In this report, we studied the effects of PGD(2) and of its major physiological metabolite, 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), on the functions of human monocyte-derived DC. First, we show that PGD(2) exerts in vitro chemotactic effects on monocytes via CRTH2 activation while it inhibits the chemokine-driven migration of monocyte-derived DC through DP. We also report that PGD(2) and 15d-PGJ(2) alter the LPS- and allergen-induced DC maturation and enhance the CD80/CD86 ratio on mature DC in a DP- and CRTH2-independent manner. Moreover, PGD(2) and 15d-PGJ(2) strongly reduce the secretion of the Th1 promoting cytokine IL-12 and affect the synthesis of chemokines involved in Th1 cell chemotaxis, particularly CXCL10. Inhibition of cytokine/chemokine secretion implicates at least in part DP, but not CRTH2. The effects exerted by PGD(2) are associated with the phosphorylation of CREB, but do not parallel with the deactivation of the NF-kappa B and mitogen-activated protein kinase pathways. In contrast, 15d-PGJ(2) seems to target other cellular proteins. Finally, in a model of Th CD45RA(+) differentiation induced by allergen- and superantigen-pulsed DC, PGD(2) impacts on the orientation of the immune response by favoring a Th2 response [less ▲]

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See detailThe family systems approach to treating families of persons with brain injury: a potential collaboration between family therapist and brain injury professional
Laroi, Frank ULg

in Brain Injury (2003), 17

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a ... [more ▼]

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a family education and support perspective and not from a family therapy perspective. The aim of the following paper is to illustrate the important role that a family systems approach can play in treating families of individuals with brain injury. In particular, clinical examples taken from the literature will be presented that illustrate how family roles can be modified as a consequence of a brain injury, and the importance of re-establishing or re-distributing these roles. It will be argued that an intimate collaboration between family therapist and brain injury professional is essential, and that the ideal professional make-up of clinicians working with families of persons with brain injury are those well-versed in both brain injury rehabilitation and family therapy. [less ▲]

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See detailFracture prevention in postmenopausal women.
Bruyère, Olivier ULg; Edwards, John; Reginster, Jean-Yves ULg

in Clinical Evidence (2003), 9

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See detailImplications cliniques de l'association d'un tonus sympathique accru, du syndrome métabolique et de l'hypertension
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (2003), 2

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See detailCantari novellistici dal Tre al Cinquecento
Moreno, Paola ULg

in Moyen Age (Le) (2003)

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See detailTowards an Understanding of Hafting: the macro- and microscopic evidence
Rots, Veerle ULg

in Antiquity (2003), 77(298), 805-815

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See detailTransmission of chronic myeloid leukemia through peripheral-blood stem-cell transplantation.
Baron, Frédéric ULg; DRESSE, Marie-Françoise ULg; Beguin, Yves ULg

in New England Journal of Medicine (2003), 349(9), 913-4

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See detailLes ateliers du Matériel: pivots de la diffusion de l'organisation rationnelle au sein de la Société Nationale des Chemins de fer Belges, 1910-1940
Geerkens, Eric ULg

in Revue d'Histoire des Chemins de Fer (2003), (28-29), 207-221

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d ... [more ▼]

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d'expérimentation, le point de diffusion de ces méthodes vers d'autres services de la société, mais aussi vers les constructeurs belges de matériel roulant. L'introduction du système de rémunération Rowan à l'atelier central de Malines (principal atelier du matériel du réseau belge) peut être tenu pour le point de départ de l'adoption de méthodes d'organisation rationnelle, dans la mesure où elle impliquait une première forme d'étude systématique du travail ouvrier. Au lendemain de la Première Guerre, une nouvelle organisation du travail d'inspiration taylorienne et son corollaire indispensable - une comptabilité industrielle - vont être introduits dans les ateliers de moyenne réparation des locomotives. Associée initialement à une concentration des ateliers, la taylorisation ne va cesser de progresser. L'adoption du travail à la chaîne pour le placement de freins à air sur ses wagons a constitué une des innovations majeures dans l'organisation du travail à la SNCB. Forte de cette expérience, la SNCB va étendre le travail à la chaîne à d'autres travaux exécutés par le service du Matériel, puis à certaines activités d'autres services. Ainsi cette technique, adoptée pour une opération ponctuelle, va être appliquée aux travaux récurrents de réparation et d'entretien du matériel roulant. Au service de l'Exploitation, la recherche d'un équilibre optimal entre les tâches successives, déterminant majeur du rendement dans le travail à la chaîne, va fournir le principe d'une organisation nouvelle du triage des wagons; de même, les travaux d'entretien des voies vont être réorganisés de manière à les faire exécuter suivant certains principes du travail à la chaîne. La baisse du trafic de marchandises et la dégradation de ses résultats financiers au début des années '30 vont amener la SNCB à approfondir la rationalisation des différents travaux, par une combinaison de techniques déjà éprouvées et de procédures nouvelles; la gestion très centralisée des ateliers va s'appuyer sur deux techniques particulières: les plannings et le contrôle budgétaire. Par une modification de ses principes d'adjudication, la société va aussi imposer le travail à la chaîne, puis le planning, à ses fournisseurs de matériel roulant, amenant ainsi une modernisation de leurs méthodes de travail. L'adoption et la diffusion des méthodes d'organisation a impliqué une très forte centralisation des structures administratives, dont une illustration est donnée par le service d'entretien des wagons, où tous les ateliers sont dirigés par le service central des wagons de la direction du Matériel. Au début de la Seconde Guerre, les limites de cette centralisation vont être perçues par les fonctionnaires dirigeants qui avaient introduit les méthodes d'organisation tayloriennes. Il en résultera une décentralisation des responsabilités; son abandon au lendemain du conflit marque toutefois le retour à une centralisation taylorienne dont les effets se feront sentir pendant plusieurs décennies. [less ▲]

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See detailOnce-weekly epoetin beta is highly effective in treating anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin production.
Cazzola, Mario; Beguin, Yves ULg; Kloczko, Janusz et al

in British Journal of Haematology (2003), 122(3), 386-93

Epoetin beta, three-times weekly (t.i.w.), is effective in reversing anaemia in lymphoproliferative disorders. The current study investigated whether an epoetin beta dose of 30,000 IU given subcutaneously ... [more ▼]

Epoetin beta, three-times weekly (t.i.w.), is effective in reversing anaemia in lymphoproliferative disorders. The current study investigated whether an epoetin beta dose of 30,000 IU given subcutaneously once weekly (q.w.) was at least as effective as 10,000 t.i.w. administration in anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin (Epo) production. Overall, 241 anaemic patients with multiple myeloma, low-grade non-Hodgkin's lymphoma or chronic lymphocytic leukaemia, all with serum Epo values </= 100 mU/ml, were randomized to receive the q.w. (n = 119) or t.i.w. (n = 122) regimen for 16 weeks. The primary efficacy criterion, i.e. the time-adjusted area under the haemoglobin-time curve from weeks 5-16, was comparable between the q.w. and t.i.w. groups [difference = - 0.20 g/dl (90% confidence interval - 0.52-0.11)]. Moreover, response rates were high and similar in both arms (72%vs 75%, q.w. and t.i.w. groups respectively). Baseline serum Epo was predictive of response: the lower serum Epo, the higher the likelihood of response (P = 0.002). Thus, epoetin beta administered q.w. is an effective and convenient treatment for anaemia in patients with lymphoproliferative disorders. Tailoring this treatment modality to subjects with defective endogenous Epo production represents a rational use of epoetin from both a medical and a community perspective. [less ▲]

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See detailLe point sur la place du Robinier en Hongrie
Fourbisseur, Anne; Charron, Stéphane; Jourez, Benoît ULg et al

in Forêt Wallonne (2003), (67), 26-30

Le robinier est une des deux essences les plus importantes en Hongrie1-2. Ce pays est mondialement reconnu comme chef de file pour la gestion de la ressource en robinier, depuis la <br />recherche en ... [more ▼]

Le robinier est une des deux essences les plus importantes en Hongrie1-2. Ce pays est mondialement reconnu comme chef de file pour la gestion de la ressource en robinier, depuis la <br />recherche en amélioration génétique jusqu’à la valorisation industrielle de son bois. Cet article se propose de faire la synthèse des connaissances acquises en Hongrie sur le développement de la <br />filière bois du robinier. L’objectif est de partager l’expérience hongroise avec ceux qui intéressent à cette essence à haut potentiel. Un bref historique de l’implantation du robinier dans ce pays sera exposé et suivi de l’état actuel de la ressource et d’une présentation succincte <br />des caractéristiques climatiques et édaphiques propres à la Hongrie. La sylviculture propre au robinier sera détaillée et les principales utilisations des produits ligneux seront décrites. Cette ynthèse s’achèvera avec la présentation de la collaboration sur le thème du robinier conclue <br />entre la Région wallonne, la Communauté française de Belgique et la République de Hongrie. [less ▲]

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See detailHistomycologie unguéale
Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg; Franchimont, Claudine ULg et al

in Annales de Dermatologie et de Vénéréologie (2003), 130

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The ... [more ▼]

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The location of and the density in fungal cells is variable. In some instances, these aspects remain clinically unsuspected. In vivo confocal microscopy can bring the same information. Computerized image analysis of histological sections is the most performant means for quantifying the fungal load. Immunohistochemistry brings information about the identity of the fungus or the association of different fungi present in the nail plate. Mixed infections may be unifocal or located at different levels in the nail apparatus. The viability of fungi as assessed by vital stains can be assessed under the microscope and quantified by flow cytometry. The different facets of nail histomycology are complementary and shed some light on aspects sometimes unsuspected of onychomycoses. [less ▲]

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See detailProcédure de liquidation-partage
Leleu, Yves-Henri ULg

in Revue de Droit de l'ULB (2003)

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See detailNumerus clausus en fin de troisieme candidature en medecine: mort annoncee d'une heresie?
Rabenda, Véronique ULg; Boniver, Jacques ULg; Reginster, Jean-Yves ULg

in Revue Médicale de Liège (2003), 58(7-8, Jul-Aug), 508-14

Owing to the establishment of a procedure aiming at a reduction of the medical supply (numerus clausus), the French Community of Belgium had decided to introduce, at the end of the third year of medical ... [more ▼]

Owing to the establishment of a procedure aiming at a reduction of the medical supply (numerus clausus), the French Community of Belgium had decided to introduce, at the end of the third year of medical studies (third candidature), a procedure of selective attribution of the certificate allowing for a unlimited medical practice. We assessed the predictive value of the results obtained during and at the end of the first candidature (first year of medicine) for the attribution of this certificate. We studied the results of the 225 students enrolled in the first candidature in medicine at the University of Liege during the academic year 1997-1998, and we correlated them to the subsequent attribution (1999-2000- and 2000-2001) of the certificate. The success of the first candidature in the first or second session is an important predicting factor towards the reception of the certificate. A non-authorization to continue the studies in medicine in case of failure in the first session or a non-authorization to repeat the first candidature in case of failure in the second session would have, respectively, a negative predictive value (NPV) of 91.9% and 97.4% and would allow to restream 111 students at the end of the first session or 39 students at the end of the first candidature. The results of the preliminary assessments mode during the month of January are also highly predictive of the chances to get the certificate. Among the 160 students who have not successfully passed a minimum of 3 exams, only 14 students obtained the certificate. The restreaming of those students would correspond to a NPV of 91.2%. Students who were not successful in a minimum of 2 exams would have less than 5% chance to obtain the certificate. In this case, 109 students would be restreamed (NPV = 95.4%). In conclusion, the selection of the students who will obtain, at the end of the third year of medicine, the certificate allowing them for an unlimited medical practice is obtained, in a large proportion, during the first candidature and especially after the session of January. In view of those results and considering the decree abolishing the selection at the end of the third year of medical studies, one could argue about the appropriateness of the current procedure, chosen by the French Community of Belgium, compared to other solutions prioritising an earlier selection of the future doctors. [less ▲]

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See detailEvaluation of false transrectal ultrasonographic pregnancy diagnoses in sheep by measuring the plasma level of pregnancy-associated glycoproteins
Karen, A.; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Reproduction Nutrition Development (2003), 43(6, NOV-DEC), 577-586

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy ... [more ▼]

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy-associated glycoproteins (ovPAG). A total of 424 Awassi x Merino ewes were synchronized for estrus and examined by transrectal ultrasonography. In Experiment 1, the ewes (n = 156) were repeatedly scanned in a standing position on d 29, 36 and 50 of gestation. Similarly, the ewes (n = 268) in Experiment 2 were scanned on d 24, 29 and 34 of gestation, but these ewes were fasted for 12 h prior to the examination and the abdominal wall of each animal was lifted up by the hands of the assistant during the scanning. Blood samples were withdrawn after each transrectal ultrasonographic examination in both experiments. Ovine PAG concentrations were measured in plasma by a heterologous radioimmunoassay and the cut-off value for pregnancy was greater than or equal to 1 ng.mL(-1). Based on the lambing performance, in Experiment 1, altogether 47 false negative and 38 false positive diagnoses were made by transrectal ultrasonography in 24 and 33 ewes, respectively between d 29 and 50 of gestation. In Experiment 2, altogether 8 false negative and 13 false positive diagnoses both were made in 7 ewes between d 24 and 34 of gestation. In both experiments, all ewes with false negative diagnoses had ovPAG concentrations higher than the threshold level for pregnancy diagnosis and all ewes with false positive diagnoses had ovPAG concentrations lower than the threshold of pregnancy. Furthermore, by the PAG-RIA test all lambed or aborted ewes (n = 63) were correctly diagnosed as pregnant and with three exceptions, all non-lambed ewes (n = 361) were correctly diagnosed as non-pregnant during the examined periods of both experiments. [less ▲]

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See detailDe la prescription acquisitive abrégée : autour et alentour du juste titre
Lecocq, Pascale ULg

in Revue Critique de Jurisprudence Belge [= RCJB] (2003)

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See detailDu nouveau en matière de crédit à la consommation
Biquet, Christine ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2003)

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See detailPrévention tertiaire de l'insuffisance rénale chronique chez l'adulte
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Médi-Sphère (2003), 197

L'insutfisance rénale chronique est une maladie méconnue, insidieuse, qui présente souvent peu je symptômes au début. Cet article veut insister sur les règles de bonne pratique pour freiner ou mieux ... [more ▼]

L'insutfisance rénale chronique est une maladie méconnue, insidieuse, qui présente souvent peu je symptômes au début. Cet article veut insister sur les règles de bonne pratique pour freiner ou mieux prévenir les complications de l'urémie et préparer si nécessaire le malade au traitement de suppléance. [less ▲]

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See detailSeismic triggering of landslides. Part B: Simulation of dynamic failure processes
Havenith, Hans-Balder ULg; Strom, A.; Calvetti, F. et al

in Natural Hazards & Earth System Sciences (2003), 3

From field observations it is possible to establish correlations between geological conditions and landslide occurrence. However, in general, it is difficult to assess the affect of individual factors on ... [more ▼]

From field observations it is possible to establish correlations between geological conditions and landslide occurrence. However, in general, it is difficult to assess the affect of individual factors on slope instability because of their mutual interaction. In addition, the dynamic effect of propagating seismic waves significantly increases the complexity of the slope stability problem. Wave diffraction, reflection and focusing effects are dependent on local geological conditions and make it difficult to analyse dynamic sliding mechanisms using field observations alone. As a consequence, in order to examine the influence of various geological and seismic factors on slope movements, it is often necessary to produce numerical models. This paper describes the results of such models as applied to two case studies in Kyrgyzstan: the Ananevo rockslide, located in granite, and the Suusamyr debris slump-flow, situated within soft sediments (see Part A: Havenith et al., 2003). Discrete element modelling (UDEC), adapted both to the discontinuous character of fractured rock and to the heterogeneity of layered mediums, was used. This permitted simulation of deformation mechanisms, including seismically induced bending, block tilting, and slip. Particular attention was paid to the interaction between deformation mechanisms, site-specific amplification effects, and subsurface structure. [less ▲]

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See detailAu delà de l’irrationalité : vers une psychologique du phénomène de harcèlement moral.
Geuzaine, Caroline; Faulx, Daniel ULg

in Cahiers Internationaux de Psychologie Sociale (2003), 48

De prime abord, les situations de harcèlement moral dégagent une impression d’irrationalité intense (Geuzaine & Faulx, 2000). Depuis notre position d’observateur extérieur, nous sommes face à un ensemble ... [more ▼]

De prime abord, les situations de harcèlement moral dégagent une impression d’irrationalité intense (Geuzaine & Faulx, 2000). Depuis notre position d’observateur extérieur, nous sommes face à un ensemble d’éléments qui heurtent la logique. Du point de vue de celui qui s’en sent victime, d’abord : une personne vit une situation d’abus sur son lieu de travail, elle nous décrit, dans un flot de détails, les agissements qu’elle subit et nous percevons l’intensité de son angoisse. Les affects sont à l’avant-plan, intenses et souvent désespérés. La personne se sent persécutée, bafouée, démolie, et pourtant tente obstinément de continuer à fonctionner dans une situation insupportable. Pourquoi ? Du point de vue de l’organisation, ensuite : le harcèlement moral, entre autres conséquences dommageables, entrave la productivité, augmente l’absentéisme, génère des surcoûts importants et détériore la qualité des produits et des services. Si un fonctionnement optimal et une bonne gestion des ressources humaines semblent un objectif profitable à l’organisation, comment le harcèlement moral peut-il s’y développer ? Lorsque l’on tente d’intégrer le « harceleur» au système compréhensif, l’irrationnel est de nouveau à l’avant-plan. En effet, les raisons qui amènent cette personne à développer un mode relationnel persécutoire ont beau être logiquement justifiées (« je veille à la qualité du travail et promeus l’excellence ». «cette personne ne répond pas aux critères », « c’est de mon devoir de la sanctionner ,«c’est pour qu’elle apprenne »), il n’en sert pas moins, même involontairement, des fins totalement irrationnelles : mettre en échec puis détruire psychologiquement une personne et l’évacuer du système professionnel en invoquant sa propre responsabilité, son déséquilibre, son inadaptation au travail. Pourquoi ? Le but de cet article est de présenter un modèle d’analyse qui permette de dépasser l’impression d’irrationalité qui se dégage des situations de harcèlement moral. Nous verrons qu’il existe une logique sous-jacente au processus de harcèlement moral; logique certes subjective et biaisée, mais à la base d’un système de comportements et d’attentes très influent. Après avoir exposé quelques repères théoriques, nous présenterons notre recherche et nos postulats méthodologiques. La partie consacrée à nos résultats s’articulera autour de deux axes : la présentation de certaines régularités parmi les situations de harcèlement moral et une réflexion sur l’aide que l’on peut proposer aux personnes qui en sont victimes. [less ▲]

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See detailTransmission of CARD15 (NOD2) variants in families with Crohns disease
Vermeire, S.; Esters, N.; Pierik, M. et al

in Gastroenterology (2003), 124(4 (Suppl I)), 368

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See detailOn Iterating Linear Transformations over Recognizable Sets of Integers
Boigelot, Bernard ULg

in Theoretical Computer Science (2003), 309(1-3), 413-468

It has been known for a long time that the sets of integer vectors that are recognizable by finite-state automata are those that can be defined in an extension of Presburger arithmetic. In this paper, we ... [more ▼]

It has been known for a long time that the sets of integer vectors that are recognizable by finite-state automata are those that can be defined in an extension of Presburger arithmetic. In this paper, we address the problem of deciding whether the closure of a linear transformation preserves the recognizable nature of sets of integer vectors. We solve this problem by introducing an original extension of the concept of recognizability to sets of vectors with complex components. This generalization allows to obtain a simple necessary and sufficient condition over linear transformations, in terms of the eigenvalues of the transformation matrix. We then show that these eigenvalues do not need to be computed explicitly in order to evaluate the condition, and we give a full decision procedure based on simple integer arithmetic. The proof of this result is constructive, and can be turned into an algorithm for applying the closure of a linear transformation that satisfies the condition to a finite-state representation of a set. Finally, we show that the necessary and sufficient condition that we have obtained can straightforwardly be turned into a sufficient condition for linear transformations with linear guards. [less ▲]

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See detailCalorimetry of cationic liposome-DNA complex and intracellular visualization of the complexes.
Elouahabi, Abdelatif; Thiry, Marc ULg; Pector, Veronique et al

in Methods in Enzymology (2003), 373

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See detailAnatomical and histological aspects of the tonsils in sheep
Gabriel, Annick ULg; Cocquyt, G.; Van den Broeck, W.

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 251-258

Since the 1st April 2002, the European Union has extended the Transmissible Spongiform Encephalopathy testing in ruminants by including sheep and goats in the survey studies. In small ruminants, presence ... [more ▼]

Since the 1st April 2002, the European Union has extended the Transmissible Spongiform Encephalopathy testing in ruminants by including sheep and goats in the survey studies. In small ruminants, presence of the agent of Bovine Spongiform Encephalopathy was demonstrated in tonsils, so these are considered as specified risk materials. This article gives an overview of the anatomical localisation and histological structure of the tonsils in small ruminants. Anatomically, 6 different tonsils can be distinguished: 3 are located in the oropharyngeal tract (tonsilla palatina, tonsilla lingualis, tonsilla veli palatini), 2 in the nasopharyngeal tract (tonsilla pharyngea and tonsilla tubaria), and one in the laryngopharyngeal tract (tonsilla paraepiglottica). Several tonsils show a cryptic overlying epithelium (cryptic tonsil) whereas other don't (non-cryptic tonsil). Several immunological features of the tonsils are described. [less ▲]

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See detailLes compétences des jeunes de 15 ans en Communauté française en lecture, en mathématiques et en sciences : résultats de l'enquête PISA 2000
Lafontaine, Dominique ULg; Baye, Ariane ULg; Burton, Réginald et al

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 13-14

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See detailOstie : la reprise des fouilles sur le site de la Schola du Trajan.
Morard, Thomas ULg

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2003), 115(1), 433-443

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See detailEnseigner autrement : une expérience à l’Université de Liège
Merenne-Schoumaker, Bernadette ULg

in Géographes Associés (2003), (27), 183-184

Analyse d'une expérience en pédagogie active développée dans le cadre du cours de géographie urbaine à l'Université de Liège

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See detailRisque cardiovasculaire global: HOPE fait vivre plus longtemps
Krzesinski, Jean-Marie ULg

in Tempo Médical (2003), 247

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les ... [more ▼]

Les maladies cardiovasculaires restent la première cause de décès chez l'adulte; c'est dire l'importance d'une prise en charge adéquate du risque, notamment en médecine générale. A cet égard, les recommandations les plus récentes vont de plus en plus dans le sens d'une prise en charge du risque cardiovasculaire global, accordant moins d'importance à la valeur absolue de chacun des facteurs de risque; les patients présentant le plus grand risque global devant, bien entendu, être prioritairement traités. Une attitude, basée sur les résultats de quelques grandes études cliniques, dont HOPE (Heart Outcomes Prevention Evaluation). Nous vous proposons ici un rappel des résultats de cette étude remarquable, ainsi qu'un commentaire sur cette nouvelle approche préventive du risque CV, en compagnie de quelques uns des orateurs du congrès Cardio 2003. [less ▲]

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See detailSubocclusion colique precoce apres traitement d'une maladie de Crohn refractaire active par infliximab.
Belaiche, Jacques ULg; Louis, Edouard ULg

in Gastroentérologie Clinique et Biologique (2003), 27(11), 1045-7

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See detailMycobacterium bovis meningitis in a cow with clinical signs of BSE.
Roels, S.; Walravens, K.; Saegerman, Claude ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2003), 152(26), 807-8

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See detailHow Daphnia copes with excess carbon in its food
Darchambeau, François ULg; Faerovig, P. J.; Hessen, D. O.

in Oecologia (2003), 136(3), 336-346

Animals that maintain near homeostatic elemental ratios may get rid of excess ingested elements from their food in different ways. C regulation was studied in juveniles of Daphnia magna feeding on two ... [more ▼]

Animals that maintain near homeostatic elemental ratios may get rid of excess ingested elements from their food in different ways. C regulation was studied in juveniles of Daphnia magna feeding on two Selenastrum capricornutum cultures contrasting in P content (400 and 80 C:P atomic ratios). Both cultures were labelled with C-14 in order to measure Daphnia ingestion and assimilation rates. No significant difference in ingestion rates was observed between P-low and P-rich food, whereas the net assimilation of C-14 was higher in the treatment with P-rich algae. Some Daphnia were also homogeneously labelled over 5 days on radioactive algae to estimate respiration rates and excretion rates of dissolved organic C (DOC). The respiration rate for Daphnia fed with high C:P algae (38.7% of body C day(-1)) was significantly higher than for those feeding on low C:P algae (25.3% of body C day(-1)). The DOC excretion rate was also higher when animals were fed on P-low algae (13.4% of body C day(-1)) than on P-rich algae (5.7% of body C day(-1)) . When corrected for respiratory losses, total assimilation of C did not differ significantly between treatments (around 60% of body C day(-1)). Judging from these experiments, D. magna can maintain its stoichiometric balance when feeding on unbalanced diets (high C:P) primarily by disposing of excess dietary C via respiration and excretion of DOC. [less ▲]

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See detailL’expérience politique des jeunes, par Anne Muxel (compte rendu)
Fournier, Bernard ULg

in Politique et Sociétés (2003), 22(2)

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See detailRhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.
Clercx, Cécile ULg; Reichler, I.; Peeters, Dominique ULg et al

in Journal of Veterinary Internal Medicine (2003), 17(6), 843-9

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK ... [more ▼]

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent rhinorrhea, cough, and respiratory dyspnea. Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected dogs, but no characteristic primary ciliary defects (primary ciliary dyskinesia) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected dogs and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected dogs tested, whereas BALF IgA concentration was above the normal range in 2 affected adult dogs. The CD4 to CD8 lymphocyte subset ratio (CD4:CD8) in peripheral blood was tested in 3 affected dogs and was within the normal range. BALF CD4:CD8 was tested in 1 affected dog and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 dogs tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss dogs revealed common ancestry, suggesting a heritable syndrome. [less ▲]

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See detailOptimisation Of Expression And Immobilized Metal Ion Affinity Chromatographic Purification Of Recombinant (His)(6)-Tagged Cytochrome P450 Hydroperoxide Lyase In Escherichia Coli
Delcarte, J.; Fauconnier, Marie-Laure ULg; Jacques, Philippe ULg et al

in Journal of Chromatography B-Analytical Technologies In the Biomedicaland Life Sciences (2003), 786(1-2),

Fatty acid hydroperoxide lyase (HPL) is a cytochrome P450 acting on fatty acid’s hydroperoxides in many plants. The optimisation of the expression of recombinant (His) -tagged HPL in Escherichia coli is ... [more ▼]

Fatty acid hydroperoxide lyase (HPL) is a cytochrome P450 acting on fatty acid’s hydroperoxides in many plants. The optimisation of the expression of recombinant (His) -tagged HPL in Escherichia coli is described: the highest HPL 6 production yield were obtained with TB medium supplemented with 2.5 mM d-aminolevulinic acid and 0.5 mM IPTG. For the first time, the time course expression of a plant P450 in a bench-scale fermentor is detailed and the amount of recombinant HPL production is 16.3 mg/ l. The UV–Visible spectrum of the recombinant (His) -tagged HPL have been recorded after a Ni -based affinity chromatography (IMAC). [less ▲]

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See detailToward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides
De Tullio, Pascal ULg; Becker, B.; Boverie, S. et al

in Journal of Medicinal Chemistry (2003), 46

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See detailE lectron–phonon couplings at C60 interfaces: a case study by two- color, infrared–visible sum–frequency generation spectroscopy
Caudano, Yves; Silien, C.; Humbert, Christophe et al

in Journal of Electron Spectroscopy & Related Phenomena (2003), 129

We demonstrate the ability of doubly resonant sum–frequency generation (DR-SFG) to investigate electron–phonon couplings at C60 –metal interfaces. Due to its coupling to electronic transitions, the ... [more ▼]

We demonstrate the ability of doubly resonant sum–frequency generation (DR-SFG) to investigate electron–phonon couplings at C60 –metal interfaces. Due to its coupling to electronic transitions, the totally symmetric Ag(2) vibration of C60 exhibits a huge enhancement of its nonlinear response for sum–frequency energies above the molecular electronic gap. We attribute this resonance to the coupling of the pentagonal pinch mode with the tiu lowest unoccupied molecular orbital (LUMO) of C60. [less ▲]

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See detailMédecine d'une culture de paix et bioterrorisme.
Pierard, Gérald ULg

in Dermatologie Actualité (2003), 79

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See detailNew or interesting lichens and lichenicolous fungi from Belgium, Luxembourg and northern France. IX.
Sérusiaux, Emmanuël ULg; Diederich, Paul; Ertz, Damien et al

in Lejeunia, Revue de Botanique (2003), 173

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See detailA local influence approach applied to binary data from a psychiatric study.
Jansen, Ivy; Molenberghs, Geert; Aerts, Marc et al

in Biometrics (2003), 59(2), 410-9

Recently, a lot of concern has been raised about assumptions needed in order to fit statistical models to incomplete multivariate and longitudinal data. In response, research efforts are being devoted to ... [more ▼]

Recently, a lot of concern has been raised about assumptions needed in order to fit statistical models to incomplete multivariate and longitudinal data. In response, research efforts are being devoted to the development of tools that assess the sensitivity of such models to often strong but always, at least in part, unverifiable assumptions. Many efforts have been devoted to longitudinal data, primarily in the selection model context, although some researchers have expressed interest in the pattern-mixture setting as well. A promising tool, proposed by Verbeke et al. (2001, Biometrics 57, 43-50), is based on local influence (Cook, 1986, Journal of the Royal Statistical Society, Series B 48, 133-169). These authors considered the Diggle and Kenward (1994, Applied Statistics 43, 49-93) model, which is based on a selection model, integrating a linear mixed model for continuous outcomes with logistic regression for dropout. In this article, we show that a similar idea can be developed for multivariate and longitudinal binary data, subject to nonmonotone missingness. We focus on the model proposed by Baker, Rosenberger, and DerSimonian (1992, Statistics in Medicine 11, 643-657). The original model is first extended to allow for (possibly continuous) covariates, whereafter a local influence strategy is developed to support the model-building process. The model is able to deal with nonmonotone missingness but has some limitations as well, stemming from the conditional nature of the model parameters. Some analytical insight is provided into the behavior of the local influence graphs. [less ▲]

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See detailThiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals
Makarchikov, Alexander F; Lakaye, Bernard ULg; Gulyai, I. E. et al

in Cellular and Molecular Life Sciences : CMLS (2003), 60(7), 1477-1488

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain ... [more ▼]

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain proteins. Here we show that ThTP exists not only in vertebrates but is present in bacteria, fungi, plants and invertebrates. Unexpectedly, we found that in Escherichia coli as well as in Arabidopsis thaliana, ThTP was synthesized only under particular circumstances such as hypoxia (E. coli) or withering (A. thaliana). In mammalian tissues, ThTP concentrations are regulated by a specific thiamine triphosphatase that we have recently characterized. This enzyme was found only in mammals. In other organisms, ThTP can be hydrolyzed by unspecific phosphohydrolases. The occurrence of ThTP from prokaryotes to mammals suggests that it may have a basic role in cell metabolism or cell signaling. A decreased content may contribute to the symptoms observed during thiamine deficiency. [less ▲]

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See detailCytokinin levels in leaves, leaf exudate and shoot apical meristem of Arabidopsis thaliana during floral transition
Corbesier, Laurent; Prinsen, Els; Jacqmard, Annie ULg et al

in Journal of Experimental Botany (2003), 54(392), 2511-2517

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis ... [more ▼]

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis thaliana has been successfully used to unravel signalling pathways by genetic and molecular approaches, but analyses are still required to determine the physiological signals involved in the control of floral transition. In this work, the putative role of cytokinins was investigated using vegetative plants of Arabidopsis (Columbia) induced to flower synchronously by a single 22 h long day. Cytokinins were analysed in leaf extracts, leaf phloem exudate and in the shoot apical meristem at different times during floral transition. It was found that, in both the leaf tissues and leaf exudate, isopentenyladenine forms of cytokinins increased from 16 h after the start of the long day. At 30 h, the shoot apical meristem of induced plants contained more isopentenyladenine and zeatin than vegetative controls. These cytokinin increases correlate well with the early events of floral transition. [less ▲]

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See detailLe vers contemporain : recherches et innovations en France dans les années 80 et 90
Purnelle, Gérald ULg

in Formes poétiques contemporaines (2003), 1

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See detailSymetrie et reproductibilite temporelle des donnees neurographiques.
Bouquiaux, Olivier ULg; Horward, A.; Wang, François-Charles ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2003), 33(4), 185-95

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected ... [more ▼]

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected from 30 healthy subjects (mean age 22 +/- 2 years). METHODS: The protocol at T1 consisted of motor nerve conduction studies of median, ulnar, peroneal and tibial nerves bilaterally, with measurement of (a) motor response size (amplitude and area); (b) terminal latency; (c) minimal, mean and maximal F-wave latency; (d) motor conduction velocity; and (e) F-wave occurrence. T1 also involved sensory nerve conduction studies of median, ulnar, radial, lateral and medial cutaneous, sural and superficial peroneal nerves bilaterally, with measurement of sensory potential size (amplitude and area) and computation of sensory conduction velocity. The protocol at T2 consisted of identical measurements from the dominant side. RESULTS AND CONCLUSION: There was a negative relationship between the variability of parameters evaluating nervous conduction and the length of the nerve segment under study. Thus, the smallest side-to-side and temporal variabilities are measured for minimal F-wave latencies (on average 2-3%). The limits of symmetry and temporal variability are particularly useful for diagnosis of unilateral peripheral neuropathy or neurophysiological follow-up of patients with neuropathy, when the variability of the parameter under study is weak and when there is a high correlation between values recorded on the left and on the right or at T1 and T2. This was the case for motor response size of tibial and ulnar nerves, sensory potential size of radial nerve and minimal F-wave latencies from each studied motor nerve. [less ▲]

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See detailA arbitragem e os grupos de sociedades
Caprasse, Olivier ULg

in Revista de Direito Bancario, do Mercado de Capitais e da Arbitragem (2003)

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See detailL'image du mois. Myiase furonculoide americaine.
Leonard, Philippe ULg; Martalo, O.; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(12), 721-2

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See detailSpinal mechanisms contribute to analgesia produced by epidural sufentanil combined with bupivacaine for postoperative analgesia
Joris, Jean ULg; Jacob, Eric; Sessler, Daniel et al

in Anesthesia and Analgesia (2003), 97

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See detailHepatitis C: screening, treatment and prevention practical guidelines
Michielsen, P.; Brenard, R.; Bourgeois, N. et al

in Acta Gastro-Enterologica Belgica (2003), 66(1), 15-19

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the ... [more ▼]

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the hepatitis C virus (HCV) load and a better response rate. Naive chronically infected HCV patients (n = 454) were randomized into two arms to receive either induction treatment with interferon alpha 2b 5 million units (MU) subcutaneously (s.c.) daily during a period of 8 weeks (arm A); or treatment with interferon alpha 2b 5 MU s.c. three times a week (TIW) for a period of 8 weeks (arm B). After week 8, interferon treatment in both arms was 3 MU s.c. TIW for a total period of 12 months. In both arms, ribavirin (1000-1200 mg orally per day) was added at week 4. Induction treatment resulted in a higher virological response at week 8 of treatment (66%vs 47%; P < 0.01). However, response at the end of treatment and at 6 months follow-up was not different (53%vs 50%, 41%vs 33%). The occurrence of adverse events and the drop-out rate were similar in both arms. Although an early virological response is observed more frequently in the induction treatment, end of treatment response and sustained responses did not differ [less ▲]

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See detailQuand l’employeur ne respecte pas les barèmes de rémunération
Kefer, Fabienne ULg

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2003), (8/9), 22-26

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See detailEGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.
Teramoto, Tetsuyuki; Qiu, Jianhua; Plumier, Jean-Christophe ULg et al

in Journal of Clinical Investigation (2003), 111(8), 1125-32

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that ... [more ▼]

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-labeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair. [less ▲]

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