References of "Scientific journals"
     in
Bookmark and Share    
See detailUne néoplasie colique de cause endocrinienne…
Beckers, Albert ULg

in Médecine et Thérapeutique (1999), 5(2), 153-159

Detailed reference viewed: 45 (0 ULg)
Full Text
Peer Reviewed
See detailThe crustal tongue melting model and the origin of massive anorthosites
Duchesne, Jean-Clair ULg; Liégeois, Jean-Paul ULg; Vander Auwera, Jacqueline ULg et al

in Terra Nova (1999), 11

Recent detailed field studies in several anorthosite complexes have shown that anorthosites are frequently linked with weakness zones in the crust which favour their emplacement at mid-crust levels ... [more ▼]

Recent detailed field studies in several anorthosite complexes have shown that anorthosites are frequently linked with weakness zones in the crust which favour their emplacement at mid-crust levels. Recent experimental data have also shown that the parent magma compositions of various anorthosite massifs lie on thermal highs in the relevant phase diagrams, indicating that these magmas cannot be derived by fractionation of peridotitic mantle melts but rather are produced by melting of gabbronoritic sources. In the Sveconorwegian province terrane boundaries have been traced in deep seismic profiles to Moho offsets or to tongues of lower crustal material underthrust to depths of 40-50 km. We therefore suggest that the parent magmas of anorthosite massifs are produced by melting of gabbronoritic rocks from the lower crust that had been thrust into the mantle by collision of terranes. [less ▲]

Detailed reference viewed: 50 (7 ULg)
Full Text
Peer Reviewed
See detailInterfacial and emulsifying properties of lipopeptides from Bacillus subtilis
Deleu, Magali ULg; Razafindralambo, Hary ULg; Popineau, Y. et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (1999), 152(1-2), 3-10

The fundamental surface-active properties at the oil/water interface and emulsifying properties of surfactin, iturin A and fengycin, lipopeptides from Bacillus subtilis, were investigated. All ... [more ▼]

The fundamental surface-active properties at the oil/water interface and emulsifying properties of surfactin, iturin A and fengycin, lipopeptides from Bacillus subtilis, were investigated. All lipopeptides reduce rapidly the dynamic interfacial tension. Among lipopeptide families, surfactin is the most effective in terms of fundamental dynamic and equilibrium interfacial properties. Lipopeptides present intermediate properties in comparison with sodium dodecyl sulfate and beta-lactoglobulin concerning the stabilizing effect towards creaming-flocculation and the resistance to coalescence. Among lipopeptides, iturin A seems to show the best resistance to creaming-flocculation whereas fengycin exhibits the highest resistance to coalescence properties. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

Detailed reference viewed: 86 (6 ULg)
Peer Reviewed
See detailEfficient Implicit Schemes for Finite Element Impact Simulation
Ponthot, Jean-Philippe ULg; Graillet, D.

in International Journal of Crashworthiness (1999), 4(3), 273-285

Detailed reference viewed: 10 (4 ULg)
Peer Reviewed
See detailPremier bilan d’activités du Centre d’Informations Vétérinaires en Pharmaco-Toxicologie
Delaunois, A.; Bloden, Serge ULg; Gustin, Pascal ULg

in Annales de Médecine Vétérinaire (1999), 143

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailEvidence for vortex staircases in the whole angular range due to competing correlated pinning mechanisms
Silhanek, Alejandro ULg; Civale, L.; Candia, S. et al

in Physical Review. B : Condensed Matter (1999), 59(21), 13620-13623

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum ... [more ▼]

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum centered at the tracks direction is observed. At low fields we identify a lock-in phase characterized by an angle-independent pinning strength and observe an angular shift of the peak towards the c axis that originates in the misalignment between vortices and applied field in anisotropic materials. The interplay among columnar defects, twins, and intrinsic pinning by the ab planes generates a variety of staircase structures. We show that correlated pinning dominates for all orientations of the applied field. [S0163-1829(99)09417-5]. [less ▲]

Detailed reference viewed: 7 (2 ULg)
Peer Reviewed
See detailLa pollution de la chaîne alimentaire par la dioxine
Maghuin-Rogister, Guy ULg; Delaunois, A.; De Pauwe, E. et al

in Annales de Médecine Vétérinaire (1999), 143

Detailed reference viewed: 42 (1 ULg)
Peer Reviewed
See detailMélanges Philippe Minguet
Duchesne, Jean-Patrick ULg

in Art&fact (1999), 18

Detailed reference viewed: 42 (4 ULg)
Full Text
Peer Reviewed
See detailDevelopment of a Cough Induction Test in Pigs: Effects of Sr 48968 and Enalapril
Moreaux, B.; Beerens, Dominique ULg; Gustin, Pascal ULg

in Journal of Veterinary Pharmacology & Therapeutics (1999), 22(6), 387-389

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailCan the standardized uptake value characterize primary brain tumors on FDG-PET?
Hustinx, Roland ULg; Smith, R. J.; Benard, F. et al

in European Journal of Nuclear Medicine (1999), 26(11), 1501-9

The aim of this study was to evaluate the usefulness of measuring the standardized uptake value (SUV) in primary brain tumors on fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET ... [more ▼]

The aim of this study was to evaluate the usefulness of measuring the standardized uptake value (SUV) in primary brain tumors on fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scans. Two groups of patients were studied. Whole-brain glucose cerebral metabolic rates (wCMRs) and SUVs were obtained in 20 normal subjects. Twenty-seven patients with histology-proven malignant primary CNS tumors (high-grade gliomas n=22, primitive neuroectodermal tumors n=3, ependymomas n=2) were also studied. The degree of FDG uptake was assessed by visual inspection and thereafter regions of interest were placed over the lesion, the contralateral cortex and white matter and the whole brain. Average (avg) and maximum (max) pixel values were determined in each site. Based on these measurements, SUV, tumor to cortex (T/C) and tumor to white matter (T/WM) activity ratios were calculated. There was no correlation between wCMRs (4.55+/-0.36 mg min(-1) 100 g(-1)) and wSUVs (5.41+/-0.43) in the normal subjects (r=0.18, P=0.45). In the second group, 17 lesions were described as definitely and seven as probably malignant. However, SUVs in these tumors and in the contralateral cortex were not significantly different. Although the SUVs were generally higher in the tumor than in the contralateral white matter, there was a significant overlap between the values. The range of the SUVs was wide: 2.54-11.8 for the tumors, 2.98-9.96 for the cortex and 1.87-6.76 for the white matter. SUVs in the normal cortex were negatively correlated with blood glucose level at the time of the injection. SUVs in the whole brain and in the cortex were lower in patients previously treated by irradiation, even months after completion of the treatment. No correlation was detectable between any of the SUVs and the age of the patients, tumor type, time post injection, use of dexamethasone, patient weight, dose injected and visual score. With cutoff levels of 1.5 for T max/WM and 0.6 for T max/C, the sensitivity of the activity ratios was 74% and 96% respectively. In conclusion, SUVs do not correlate with CMRs across subjects and appear to be of limited value in characterizing brain tumors. Visual assessment and measurement of the activity ratios currently remain the most reliable methods of analysis. [less ▲]

Detailed reference viewed: 24 (2 ULg)
Peer Reviewed
See detailPharmacological treatment of obesity: present status.
Scheen, André ULg; Lefebvre, Pierre ULg

in International Journal of Obesity & Related Metabolic Disorders (1999), 23 Suppl 1

OBJECTIVE: Obesity poses a serious health hazard and its treatment is often disappointing. This review describes the present status of pharmacological treatment of obesity in man. DESIGN: Obesity ... [more ▼]

OBJECTIVE: Obesity poses a serious health hazard and its treatment is often disappointing. This review describes the present status of pharmacological treatment of obesity in man. DESIGN: Obesity treatment may include drugs that reduce food intake, drugs that increase energy expenditure and drugs that affect nutrient partitioning or metabolism. The mode of action, efficacy and safety of each approach will be briefly discussed. RESULTS: All of the pharmacological possibilities have potential activities, but also serious limitations. While current anti-obesity pharmacotherapy essentially uses centrally-acting anorectic drugs, severe side-effects (more particularly pulmonary hypertension and valvular heart disease) have been reported, leading to the withdrawal of licensed fenfluramine and d-fenfluramine. New approaches have been recently proposed, such as sibutramine, an amine reuptake inhibitor which decreases food intake, and orlistat, an intestinal lipase inhibitor which decreases fat absorption. Obesity is a chronic disease and should be treated as such with reasonable expectations. Large-scale one-year placebo-controlled studies demonstrated that d-fenfluramine, sibutramine and orlistat significantly increased body weight loss by an average of 2-4 kg when compared to placebo and, more interestingly, multiplied by 2-3 the number of patients who succeeded in obtaining and maintaining a reduction of more than 10% of initial body weight. Interestingly, some of these compounds may also exert favourable effects on other vascular risk factors, independently of weight loss. CONCLUSIONS: Even if all anti-obesity pharmacological approaches can be helpful, they also have important limitations so that other strategies including either combined therapies or new drugs (peptides) are currently under investigation. [less ▲]

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailLa place Saint-Lambert et l’œil liégeois
Dupagne, A.; Teller, Jacques ULg

in Annales du Bâtiment et des Travaux Publics (1999), (1), 33-44

Detailed reference viewed: 50 (18 ULg)
Peer Reviewed
See detailBooklist 1998
Pirenne, Christophe ULg; Mitsui, Toru

in Popular Music (1999), 18(3), 425-446

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailSimultaneous Reactivation of Herpes Simplex Virus and Varicella-Zoster Virus in a Patient with Idiopathic Thrombocytopenic Purpura
Nikkels, Arjen ULg; Frere, P.; Rakic, L. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1999), 199(4), 361-364

Simultaneous reactivation of distinct Herpesviridae with development of clinical manifestations is exceptional. We report a 48-year-old woman suffering from idiopathic thrombocytopenic purpura. As the ... [more ▼]

Simultaneous reactivation of distinct Herpesviridae with development of clinical manifestations is exceptional. We report a 48-year-old woman suffering from idiopathic thrombocytopenic purpura. As the disease remained refractory to corticosteroids, immunoglobulins and splenectomy, a cure of vinblastine was administered. An atypical stomatitis developed few days later. Immunohistochemistry on a Tzanck smear and a biopsy evidenced a Herpes simplex virus type 1 (HSV-1) infection. The patient presented simultaneously a single necrotic lesion on the abdomen. Immunohistochemistry on a skin biopsy revealed the presence of the varicella-zoster virus (VZV) gE, gB and IE63 proteins. Intravenous aciclovir was initiated. The present case of simultaneous clinical infections by HSV-I and VZV underlines the importance of complementary viral identification testing in the event of unusual clinical presentations. [less ▲]

Detailed reference viewed: 28 (4 ULg)
See detailBibliographie concernant la loi de protection des malades mentaux
Boxho, Philippe ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1999), 21

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailPotential applications of PET imaging in developing novel cancer therapies.
Hustinx, Roland ULg; Eck, S. L.; Alavi, A.

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1999), 40(6), 995-1002

Detailed reference viewed: 8 (2 ULg)
Peer Reviewed
See detailSerine peptidase catalytic machinery: Cooperative one-step mechanism
Dive, Georges ULg; Dehareng, Dominique ULg

in International Journal of Quantum Chemistry (1999), 73(2), 161-174

The acylation reaction of beta-lactamases by beta-lactam compounds is modeled as a one-step process. Twenty seven transition-state models are investigated at the restricted Hartree-Fock (RHF) level within ... [more ▼]

The acylation reaction of beta-lactamases by beta-lactam compounds is modeled as a one-step process. Twenty seven transition-state models are investigated at the restricted Hartree-Fock (RHF) level within the minimal MINI-1' basis set. These transition states differ by the nature of both the substrate and the amino acids constituting the reactive nucleophile. The intrinsic reactivity of the class-A and class-C beta-lactamases are under concern. Eight transition-state models were docked in a class-A beta-lactamase, TEM1, as optimized with the benzylpenicillin at the molecular mechanics level. In the proposed one-step acylation process, only two amino acids are directly involved, the usual nucleophilic serine, S70 in TEM1, and a close serine or tyrosine, S130 in TEM1, Y150 in P99. The lysine close to these two residues, K73 in TEM1, plays only an indirect role in the process. (C) 1999 John Wiley & Sons, Inc. Int J Quant Chem 73: 161-174, 1999. [less ▲]

Detailed reference viewed: 29 (2 ULg)
Full Text
Peer Reviewed
See detailIntragranular and intergranular superconducting properties of bulk melt-textured YBCO
Vanderbemden, Philippe ULg; Cloots, Rudi ULg; Ausloos, Marcel ULg et al

in IEEE Transactions on Applied Superconductivity (1999), 9(2), 2308-2311

We have investigated the superconducting properties of bulk melt-processed YBCO using different experimental techniques. First, single domain materials (i.e. containing no grain boundaries) have been ... [more ▼]

We have investigated the superconducting properties of bulk melt-processed YBCO using different experimental techniques. First, single domain materials (i.e. containing no grain boundaries) have been studied. Electrical resistivity, current-voltage characteristics, M-H loops, and A,C. susceptibility. have been measured for different field and current directions. The intragranular properties are characteristic of high-quality melt-processed YBCO material,,vith a critical current density J(c)(T=77K, B=1T//c) > 10(4) A/cm(2). The anisotropy ratio J(c)(ab)/ J(c)(c) is found to be close to 3. Both magnetic and transport measurements show that defects in the microstructure do not significantly impede the current flow inside the single domain. These results were compared to those measured on samples containing one "natural" single grain boundary which sometimes appears during the grain growth process. The intergranular properties show a much stronger current and magnetic field dependence than that measured within the grain and these differences are discussed. [less ▲]

Detailed reference viewed: 19 (3 ULg)
Peer Reviewed
See detailP300 event-related potential and serotonin-1A activity in depression.
Hansenne, Michel ULg; Ansseau, Marc ULg

in European Psychiatry (1999), 14(3), 143-7

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.40, P = 0.007 at Cz; r = -0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude. [less ▲]

Detailed reference viewed: 20 (1 ULg)
Full Text
See detailLa mesure du courant critique des matériaux supraconducteurs à haute température critique
Vanderbemden, Philippe ULg

in Bulletin de l'Association des Ingénieurs sortis de l'Université de Liège (AILg) (1999), 6

Detailed reference viewed: 49 (7 ULg)
Peer Reviewed
See detailGrowth Hormone and parturition adversely influence immuno-reactive Plasma Insulin-like Growth Factor Binding Protein-2 in Cattle
Vleurick, Lieve; Vandehaar, Michael; Bertozzi, Carlo et al

in Growth Regulation (1999), 9

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailLa vaccination contre le virus respiratoire syncytial bovin
Thiry, Etienne ULg; Pastoret, Paul-Pierre ULg; Valarcher, J. F. et al

in Bulletin des Groupements Techniques Vétérinaires (1999), 5

Detailed reference viewed: 58 (3 ULg)
Peer Reviewed
See detailAnimal model genetic evaluation of type traits for five dairy cattle breeds
Gengler, Nicolas ULg; Wiggans, G. R.; Wright, J. R.

in Journal of Dairy Science (1999), 82(6), 13501-135022

Detailed reference viewed: 9 (0 ULg)
See detail«Verità e metodo nella scrittura di Leonardo Sciascia»
Moreno, Paola ULg

in Esperienze letterarie (1999)

Detailed reference viewed: 38 (4 ULg)
Peer Reviewed
See detailMolecular Cloning And Characterization Of The Enzyme Udp-Glucose: Protein Transglucosylase From Potato
Bocca, Sn.; Kissen, R.; Rojas-Beltran, Ja. et al

in Plant Physiology and Biochemistry (1999), 37(11),

See detailManoscritti teatrali della Biblioteca Riccardiana di Firenze.
Moreno, Paola ULg

in Scriptorium (1999)

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detail16K Human Prolactin Inhibits Vascular Endothelial Growth Factor-Induced Activation of Ras in Capillary Endothelial Cells
D'Angelo, Gisela; Martini, Jean-François; Iiri, Taroh et al

in Molecular Endocrinology (Baltimore, Md.) (1999), 13(2), 692-704

Signaling pathways mediating the antiangiogenic action of 16K human (h)PRL include inhibition of vascular endothelial growth factor (VEGF)-induced activation of the mitogen-activated protein kinases (MAPK ... [more ▼]

Signaling pathways mediating the antiangiogenic action of 16K human (h)PRL include inhibition of vascular endothelial growth factor (VEGF)-induced activation of the mitogen-activated protein kinases (MAPK). To determine at which step 16K hPRL acts to inhibit VEGF-induced MAPK activation, we assessed more proximal events in the signaling cascade. 16K hPRL treatment blocked VEGF-induced Raf-1 activation as well as its translocation to the plasma membrane. 16K hPRL indirectly increased cAMP levels; however, the blockade of Raf-1 activation was not dependent on the stimulation of cAMP-dependent protein kinase (PKA), but rather on the inhibition of the GTP-bound Ras. The VEGF-induced tyrosine phosphorylation of the VEGF receptor, Flk-1, and its association with the Shc/Grb2/Ras-GAP (guanosine triphosphatase-activating protein) complex were unaffected by 16K hPRL treatment. In contrast, 16K hPRL prevented the VEGF-induced phosphorylation and dissociation of Sos from Grb2 at 5 min, consistent with inhibition by 16K hPRL of the MEK/MAPK feedback on Sos. The inhibition of Ras activation was paralleled by the increased phosphorylation of 120 kDa proteins comigrating with Ras-GAP. Taken together, these findings show that 16K hPRL inhibits the VEGF-induced Ras activation; this antagonism represents a novel and potentially important mechanism for the control of angiogenesis. [less ▲]

Detailed reference viewed: 32 (3 ULg)
Full Text
Peer Reviewed
See detailRegole e pratiche in caso di stato di necessità nell'età romana classica
Gerkens, Jean-François ULg

in Règle et pratique du droit dans les réalités juridiques de l'Antiquité (1999)

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailPyrométamorphisme induit par la gézéification souterraine de niveaux charbonneux du Westphalien dans le Bassin de Mons (Belgique)
Nzali, Timothée; Duchesne, Jean-Clair ULg; Jacquemin, Christiane et al

in Geologica Belgica (1999), 2(3-4), 221-234

Detailed reference viewed: 27 (4 ULg)
Full Text
Peer Reviewed
See detailBovine Leukemia Virus-Induced Persistent Lymphocytosis In Cattle Does Not Correlate With Increased Ex Vivo Survival Of B Lymphocytes
Dequiedt, Franck ULg; Cantor, Gh.; Hamilton, Vt. et al

in Journal of Virology (1999), 73(2),

Detailed reference viewed: 14 (2 ULg)
Peer Reviewed
See detailFibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review.
VAN DAMME, Hendrik ULg; SakalihasanN, Natzi ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1999), 99(4), 163-8

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two ... [more ▼]

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two suffered from a minor stroke, four had non-focalized ischemic cerebral symptoms and two were asymptomatic. At angiography, all patients showed a typical image of "string of beads". Seven patients were operated on. Six had endoluminal graduated dilatation, with rigid dilators up to 4.5 mm, associated with thrombendarterectomy of the bifurcation in three and to correction of a kink in one case. In one case a venous interposition graft was done to exclude a saccular microaneurysm of the dysplasic internal carotid artery. In another case, backflow was insufficient after endoluminal dilatation, and a long venous patch allowed to restitute a normal vascular lumen. There was neither postoperative mortality nor stroke. Six patients, asymptomatic or with non focalized symptoms, were treated medically. During a mean follow-up of 47 months, only one of the 13 patients developed a transient ischemic attack; the patient had not been operated on and received only medical treatment. Prevalence, etiopathology, diagnosis and management of fibromuscular dysplasia of the internal carotid artery are discussed. Fibromuscular dysplasia is a rare cause of cerebral ischemia. For asymptomatic lesions, a conservative approach seems appropriate. Surgery is only to be considered for symptomatic lesions. Surgical graduated endoluminal dilatation, where necessary combined with standard endarterectomy of the carotid bifurcation, is a safe, efficient and durable operation. Some complex cases of fibromuscular dysplasia may necessitate patch insertion or excision and graft interposition. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailLa mora debitoris est-elle une faute?
Gerkens, Jean-François ULg

in Mélanges offerts en l'Honneur de Fritz Sturm (1999), I

Detailed reference viewed: 39 (6 ULg)
Peer Reviewed
See detailLa démocratie et le lieu vide du pouvoir
Delruelle, Edouard ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1999), 85-87

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailLys13 plays a crucial role in the functional adaptation of the thermophilic triose-phosphate isomerase from Bacillus stearothermophilus to high temperatures
Alvarez, Marco; Wouters, Johan; Maes, Dominique et al

in Journal of Biological Chemistry (1999), 274(27), 19181-7

The thermophilic triose-phosphate isomerases (TIMs) of Bacillus stearothermophilus (bTIM) and Thermotoga maritima (tTIM) have been found to possess a His12-Lys13 pair instead of the Asn12-Gly13 pair ... [more ▼]

The thermophilic triose-phosphate isomerases (TIMs) of Bacillus stearothermophilus (bTIM) and Thermotoga maritima (tTIM) have been found to possess a His12-Lys13 pair instead of the Asn12-Gly13 pair normally present in mesophilic TIMs. His12 in bTIM was proposed to prevent deamidation at high temperature, while the precise role of Lys13 is unknown. To investigate the role of the His12 and Lys13 pair in the enzyme's thermoadaptation, we reintroduced the "mesophilic residues" Asn and Gly into both thermophilic TIMs. Neither double mutant displayed diminished structural stability, but the bTIM double mutant showed drastically reduced catalytic activity. No similar behavior was observed with the tTIM double mutant, suggesting that the presence of the His12 and Lys13 cannot be systematically correlated to thermoadaptation in TIMs. We determined the crystal structure of the bTIM double mutant complexed with 2-phosphoglycolate to 2.4-A resolution. A molecular dynamics simulation showed that upon substitution of Lys13 to Gly an increase of the flexibility of loop 1 is observed, causing an incorrect orientation of the catalytic Lys10. This suggests that Lys13 in bTIM plays a crucial role in the functional adaptation of this enzyme to high temperature. Analysis of bTIM single mutants supports this assumption. [less ▲]

Detailed reference viewed: 13 (3 ULg)
See detailLe projet TEEODE
Denis, Brigitte ULg; Detroz, Pascal ULg

in Instruzione a distanza (1999), 11(15), 5-9

Detailed reference viewed: 17 (8 ULg)
Full Text
Peer Reviewed
See detailGeneration of T lymphocytes from the epithelium and stroma of squamous pre-neoplastic lesions of the uterine cervix.
Jacobs, Nathalie ULg; Giannini, Sandra ULg; Al-Saleh, Walid et al

in Journal of Immunological Methods (1999), 223(1), 123-9

In this study, we have developed a simple and efficient technique for the isolation of viable lymphocytes from the epithelium and stroma of small pre-neoplastic squamous intraepithelial lesions (SIL) of ... [more ▼]

In this study, we have developed a simple and efficient technique for the isolation of viable lymphocytes from the epithelium and stroma of small pre-neoplastic squamous intraepithelial lesions (SIL) of the uterine cervix. Following the separation of the epithelium from the stroma using dispase II, both biopsy fragments were used to generate T lymphocytes. The stroma-derived lymphocytes were obtained by collecting and culturing the cells migrating out of the biopsy in the presence of IL2 (50 U/ml). An average of 0.7 x 10(6) and 1.4 x 10(6) lymphocytes could be obtained after 20 and 30 days of culture, respectively. For the expansion of lymphocytes derived from the pre-neoplastic epithelium (SIL) it was necessary to use a combination of irradiated peripheral blood mononuclear cells (PBMC) as a feeder layer with PHA (0.1%), in addition to IL2 (50 U/ml). Interestingly, these lymphocytes could be obtained using either allogeneic or syngeneic PBMCs. With this protocol, we were able to generate up to 100 x 10(6) lymphocytes from the epithelium, the majority of which were T lymphocytes. [less ▲]

Detailed reference viewed: 27 (3 ULg)
See detailL'enseignement à distance : quelques exemples européens
Denis, Brigitte ULg; Detroz, Pascal ULg

in Instruzione a distanza (1999), 11(15), 10-45

Detailed reference viewed: 13 (7 ULg)
Full Text
Peer Reviewed
See detailLa mortalité embryonnaire. 1. Aspects cliniques et facteurs étiologiques dans l'espèce bovine
Hanzen, Christian ULg; Drion, Pierre ULg; Lourtie, O. et al

in Annales de Médecine Vétérinaire (1999), 143

Detailed reference viewed: 126 (9 ULg)
Peer Reviewed
See detailThe crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures
Maes, Dominique; Zeelen, Johan P.; Thanki, Narmada et al

in Proteins (1999), 37(3), 441-53

The molecular mechanisms that evolution has been employing to adapt to environmental temperatures are poorly understood. To gain some further insight into this subject we solved the crystal structure of ... [more ▼]

The molecular mechanisms that evolution has been employing to adapt to environmental temperatures are poorly understood. To gain some further insight into this subject we solved the crystal structure of triosephosphate isomerase (TIM) from the hyperthermophilic bacterium Thermotoga maritima (TmTIM). The enzyme is a tetramer, assembled as a dimer of dimers, suggesting that the tetrameric wild-type phosphoglycerate kinase PGK-TIM fusion protein consists of a core of two TIM dimers covalently linked to 4 PGK units. The crystal structure of TmTIM represents the most thermostable TIM presently known in its 3D-structure. It adds to a series of nine known TIM structures from a wide variety of organisms, spanning the range from psychrophiles to hyperthermophiles. Several properties believed to be involved in the adaptation to different temperatures were calculated and compared for all ten structures. No sequence preferences, correlated with thermal stability, were apparent from the amino acid composition or from the analysis of the loops and secondary structure elements of the ten TIMs. A common feature for both psychrophilic and T. maritima TIM is the large number of salt bridges compared with the number found in mesophilic TIMs. In the two thermophilic TIMs, the highest amount of accessible hydrophobic surface is buried during the folding and assembly process. [less ▲]

Detailed reference viewed: 31 (2 ULg)
Peer Reviewed
See detailAn imprinted QTL with major effect on muscle mass and fat deposition maps to the IgfII locus in pigs
Nezer, C.; Moreau, L.; Brouwers, B. et al

in Nature Genetics (1999), 21

Detailed reference viewed: 34 (12 ULg)
See detailL'université, entre pouvoirs et contre-pouvoir
Bachelet, Jean-François ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1999), 85-86-87(1999), 51-60

Réflexion sur la signification du processus de transformation de l'institution universitaire.

Detailed reference viewed: 101 (31 ULg)
Peer Reviewed
See detailLa diabete de type 2: approaches diagnostiques, objectifs glycemiques et strategies therapeutiques.
Scheen, André ULg; Paquot, Nicolas ULg

in Revue Médicale de Liège (1999), 54(8), 659-66

Type 2 diabetes is a prevalent disease, with high morbidity and mortality rates, which is usually managed by general practitioners. We will discuss the new diagnostic approaches, the glycaemic goals and ... [more ▼]

Type 2 diabetes is a prevalent disease, with high morbidity and mortality rates, which is usually managed by general practitioners. We will discuss the new diagnostic approaches, the glycaemic goals and the therapeutic strategies which may contribute to improve both adequate management and prognosis of diabetic patients with type 2 diabetes. As far as possible, the management should be both individualized and integrated, not only focused on blood glucose control but also on the correction of other vascular risk factors frequently associated with diabetes (mainly arterial hypertension and dyslipidaemias). Obviously, the reduction of the incidence and severity of microangiopathy and macroangiopathy diabetic complications would require a tight collaboration between general practitioners and specialized physicians. [less ▲]

Detailed reference viewed: 47 (0 ULg)
Full Text
Peer Reviewed
See detailApplication of Miller's theorem to the stability analysis of numerical schemes; some useful tools for rapid inspection of discretisations in ocean modelling
Beckers, Jean-Marie ULg

in Ocean Modelling (1999), 1

An old theorem about the roots of a polynomial is resurfaced and examined, focusing on the practical question of determining stability criteria for numerical schemes. Is is demonstrated that the theorem ... [more ▼]

An old theorem about the roots of a polynomial is resurfaced and examined, focusing on the practical question of determining stability criteria for numerical schemes. Is is demonstrated that the theorem can be useful both for analytical studies of the stability limits, as well as numerical searches for stability regions. It is particularly important that when deciding whether the scheme is stable or not, it is not necessary to search for the roots of the polynomial. Indeed, such a decision may be reached through a finite and small number of arithmetic operations and verifications of inequalities. In addition to the analysis of the theorem, some practical conditions for polynomial of different orders are presented, as well as some useful tips on how simply necessary or sufficient stability conditions can be obtained. [less ▲]

Detailed reference viewed: 40 (0 ULg)
Peer Reviewed
See detailCompétences et savoirs terminaux en géographie. Réflexions et propositions.
Merenne-Schoumaker, Bernadette ULg

in Cahiers de Géographie du Quebec (1999), 43(120), 437-449

On the occasion of the research projects initiated by the French Community of Belgium (Communauté Française de Belgique) as an application of its decree «Missions» (24.7.1997), this article develops some ... [more ▼]

On the occasion of the research projects initiated by the French Community of Belgium (Communauté Française de Belgique) as an application of its decree «Missions» (24.7.1997), this article develops some reflections and propositions concerning the geography courses during the last four years of the general and technological education. They are based on the notion of competence as well as on the definition of the necessary final competences in geography, which permits a new focusing of the learning procedures and a better organisation, in view of the objectives to attain. Moreover, the article tries to identify the geographical knowledge that is considered as necessary for the application of these competences. In fact, this one has been classified in three groups, each one concerning respectively : spatial references, keys for the study of the territorial organisations and study of particular themes. [less ▲]

Detailed reference viewed: 25 (2 ULg)
Peer Reviewed
See detailEvaluation du système de financement des journées hospitalières en fonction des pathologies
Fecher-Bourgeois, Fabienne ULg; Gillet, Pierre ULg

in Bulletin des Résumés d'Informations Hospitalières / Ministère des affaires sociales, de la santé publique et de l'environnement (1999), 16(Janvier/février/mars 1999),

Detailed reference viewed: 25 (7 ULg)
Full Text
Peer Reviewed
See detailIntérêt clinique de la tomographie à émission de positons dans la détection et le bilan d'extension des lymphomes non Hodgkiniens de malignité intermédiaire ou élevée
Najjar, Fadi; Jerusalem, Guy ULg; Paulus, Patrick et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (1999), 23

Accurate staging of non-Hodkin's lymphoma (NHL) is important for treatment management. We studied 53 patients (40 patients at initial diagnosis and 13 patients at disease recurrence) with ... [more ▼]

Accurate staging of non-Hodkin's lymphoma (NHL) is important for treatment management. We studied 53 patients (40 patients at initial diagnosis and 13 patients at disease recurrence) with histopathologically proven aggressive NHL to assess the value of whole-body FDG positron emission tomography (PET) as an imaging modality for staging and restaging NHL. All patients in this comparative analysis were submitted to clinical examination ; computed tomography (CT) and whole-body PET studies before starting the treatment. Results : whole-body FDG-PET seems to be more sensitive than clinical examination and CT imaging for detection of lymph node regions infiltrated by NHL : there were 98 abnormal peripheral lymph node regions senn by FDG-PET : 59 observed by clinical examination and 39 clinically undetected. The clinical examination showed 9 additional nodal lesions not seen by PET. Of 77 thoracic and abdominopelvic trated by CT. The CT studies showed 5 additional nodal lesions. Extranodal lymphomatous localisations in the liver (n=5), spleen (n=14), lungs (n=8), pleura (n=9), digestive tract (n=4), pelvis (n=2) and other sites (n=9) were identified by PET. Bone marrow infiltration demonstrated by PET was confirmed by biopsy in 6/10 patients, however known medullary invasion was not seen by PET imaging in 5 patients. Conclusion : whole-body FDG-PET without attenuation correction is an efficient, non-invasive method for staging and restaging aggressive NHL but marrow biopsy remains to be performed in addition to PET. [less ▲]

Detailed reference viewed: 69 (1 ULg)
Full Text
Peer Reviewed
See detailParamètres hydrologiques et physicochimiques de sources de haute Belgique : ébauche d'une typologie régionale
Petit, François ULg; Araujo, J.; Brassine, B. et al

in Bulletin de la Société Géographique de Liège (1999)

Detailed reference viewed: 29 (11 ULg)
Peer Reviewed
See detailL'etude clinique du mois. Prevention des accidents vasculaires cerebraux chez les patients avec fibrillation auriculaire.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(6), 561-3

A recent analysis of the literature, published in the 19 May issue of the JAMA, once again demonstrates the efficacy of warfarin, and its superiority on aspirin, in preventing stroke in patients with ... [more ▼]

A recent analysis of the literature, published in the 19 May issue of the JAMA, once again demonstrates the efficacy of warfarin, and its superiority on aspirin, in preventing stroke in patients with atrial fibrillation, at least in subjects at highest risk. However, a feasibility study, published in the 15 May issue of the British Medical Journal, points to the difficulties of implementing guidelines from evidence-based medicine in general practice, essentially because of the reluctance of the physician and/or the patient when the constraints, risks and even advantages of antithrombotic treatment are taken into account. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailImpact de l’ammoniac sur le système respiratoire du porc
Gustin, Pascal ULg

in Bulletin de l'Académie Royale de Médecine de Belgique (1999), 154

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailL'observance therapeutique.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(11), 854-8

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication compliance seems to be rather low as 30 to 60% of no or poor adherence to medical ... [more ▼]

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication compliance seems to be rather low as 30 to 60% of no or poor adherence to medical recommendation have been reported. Numerous factors may influence medication compliance among which patient's characteristics, disease particularities, drug treatment modalities or physician's attitudes. The consequences of medication non-compliance may not only be dangerous for patient's health, but also dramatically increase the financial cost for public health services. Thus, all energies should be devoted to improve drug compliance, including treatment optimization and simplification, patient's information and education, use of practical means that facilitate adherence to medical recommendation, the patient being responsible for his/her treatment. [less ▲]

Detailed reference viewed: 64 (7 ULg)
Peer Reviewed
See detailFertilization by proxy: Rival sperm removal and translocation in a beetle
Haubruge, Eric ULg; Arnaud, L.; Mignon, Jacques ULg et al

in Proceedings of the Royal Society of London Series B-Biological Sciences (1999), 266(1424), 1183-1187

Detailed reference viewed: 9 (2 ULg)
Peer Reviewed
See detailLe diabete gestationnel: definition, depistage et traitement.
Geronooz, I.; Scheen, André ULg; Foidart, Jacqueline ULg

in Revue Médicale de Liège (1999), 54(5), 429-33

Defined as glucose intolerance with onset or first recognition during pregnancy, gestational diabetes mellitus represents in fact an heterogeneous clinical entity which may concern 1 to 4% of all pregnant ... [more ▼]

Defined as glucose intolerance with onset or first recognition during pregnancy, gestational diabetes mellitus represents in fact an heterogeneous clinical entity which may concern 1 to 4% of all pregnant women in our country. Its adverse effects on the mother and her child, the need for a universal screening and the mode of screening are still controversial. Screening may be made either by a first test with a 50 g oral glucose load (the so-called O'Sullivan test), confirmed if positive by a 100 g oral glucose tolerance test (OGTT), or at first glance by a 75 g OGTT performed between the 24th and 28th weeks of gestation. The treatment of gestational diabetes is based on diet. In case of diet failure to obtain good glucose control, insulin therapy should be proposed. [less ▲]

Detailed reference viewed: 184 (3 ULg)
Peer Reviewed
See detailUse of (co)variance functions to describe (co)variances for test day yield
Tijani, A.; Wiggans, G. R.; Van Tassell, C. P. et al

in Journal of Dairy Science (1999), 82(1), 2261-22614

Detailed reference viewed: 7 (1 ULg)
Peer Reviewed
See detailL'etude clinique du mois. L'etude LIPID: "long-term intervention withpravastatin in ischaemic disease".
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 2-3

The LIPID study is a placebo-controlled, double-bind, randomized trial, performed in 9014 patients with coronary heart disease and total cholesterol levels of 155 to 271 mg/dl. After a mean follow-up of 6 ... [more ▼]

The LIPID study is a placebo-controlled, double-bind, randomized trial, performed in 9014 patients with coronary heart disease and total cholesterol levels of 155 to 271 mg/dl. After a mean follow-up of 6.1 years, patients receiving pravastatin (40 mg/day) had significantly (p < 0.001) lower death rate from coronary heart disease (24%), lower overall mortality (22%) and lower incidence of all cardiovascular outcomes (20 to 29% depending on the event). Interestingly enough, the reduction in death from coronary heart disease or nonfatal myocardial infarction was observed whatever the initial cholesterol concentration, and already significant if total cholesterol was < 213 mg/dl and LDL cholesterol was < 135 mg/dl. Thus, in secondary prevention, the favourable effect of the statin on the coronary heart disease outcomes is observed even in case of initial cholesterol levels yet considered as "normal". [less ▲]

Detailed reference viewed: 42 (0 ULg)
Peer Reviewed
See detailL'etude clinique du mois. Etudes cliniques a long terme (1-2 ans) avec l'orlistat, nouveau medicament pour le traitement de l'obesite.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(8), 707-9

Orlistat (Xenical), whose original mechanism of action consists of the selective inhibition of gastrointestinal lipases, has been recently commercialized for the treatment of obesity. Despite its recent ... [more ▼]

Orlistat (Xenical), whose original mechanism of action consists of the selective inhibition of gastrointestinal lipases, has been recently commercialized for the treatment of obesity. Despite its recent launch and when compared to common anorectic agents, it has been much better evaluated in long-term trials carried out according to the rules of Good Clinical Practice. We will summarize the four recently published randomized, placebo-controlled, double-blind clinical trials lasting up to 1 to 2 years and evaluating the effects of orlistat 3 x 120 mg/day in obese patients (BMI > or = 28 kg/m2). [less ▲]

Detailed reference viewed: 22 (0 ULg)
Peer Reviewed
See detailEtude électrophysiologique des mécanismes responsables de la fatigue chronique dans la sclérose en plaques (SEP)
DELVAUX, Valérie ULg; ALAGONA, G.; GERARD, Pascale ULg et al

in Revue Neurologique (1999), 155(1S51, supp. 1),

Detailed reference viewed: 32 (1 ULg)
Peer Reviewed
See detailLe risque cardio-vasculaire lie a l'hypercholesterolemie: d'un continuum a la notion de normalite, de seuil d'intervention et d'objectif therapeutique.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 17-21

There appears to be a continuum between the cardiovascular risk and the level of blood cholesterol, which hinders the definition of normal values, intervention threshold and therapeutic goals. The more ... [more ▼]

There appears to be a continuum between the cardiovascular risk and the level of blood cholesterol, which hinders the definition of normal values, intervention threshold and therapeutic goals. The more and more convincing evidences provided by the "Evidence-Based Medicine" should be confronted to the pharmaco-economical constraints in order to first focus the essential of the efforts and resources on the target population with the highest risk. Unfortunately, the therapeutic strategy concerns a rather high percentage of the population of industrialized countries. [less ▲]

Detailed reference viewed: 37 (0 ULg)
Peer Reviewed
See detailImpact de l'ammoniac sur le système respiratoire du porc. Etude de la relation dose-réponse
Gustin, Pascal ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154(6, Pt 2), 371-375

The effects of ammonia on the respiratory system and somatic growth have been measured in piglets taking into account the interactions with endotoxins from gram-bacteria and dust. Dose-response curves ... [more ▼]

The effects of ammonia on the respiratory system and somatic growth have been measured in piglets taking into account the interactions with endotoxins from gram-bacteria and dust. Dose-response curves were constructed for the inflammatory reactions induced in nasal cavities, the smooth muscle hyperresponsiveness in the trachea, the permeability of alveolo-capillary barrier, the pulmonary vasomotricity, the cough reflex and the systemic effects. An acceptable level of pollution was proposed. [less ▲]

Detailed reference viewed: 55 (1 ULg)
Peer Reviewed
See detailLa sécheresse buccale en gériatrie
Hockers, Thierry ULg; Lamy, Marc ULg

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (1999), 54(1), 41-50

Dry mouth is usual in geriatrics. It doesn't seem a age related change of salivary gland tissues, but as often as not, it results from the use of some drugs. Seventy percents of institutionalised elderly ... [more ▼]

Dry mouth is usual in geriatrics. It doesn't seem a age related change of salivary gland tissues, but as often as not, it results from the use of some drugs. Seventy percents of institutionalised elderly population consummate these medications with buccal significance. This publication tries to summarize the means of diagnosis and the possibilities to treat this pathology. [less ▲]

Detailed reference viewed: 150 (4 ULg)
Full Text
Peer Reviewed
See detailPunch Press Vibration Isolation: a Case History
Golinval, Jean-Claude ULg; Géradin, Michel ULg

in European Journal of Mechanical and Environmental Engineering (1999), 44(3), 141-145

Detailed reference viewed: 31 (0 ULg)
Peer Reviewed
See detailLattice dynamics of BaTiO3, PbTiO3, and PbZrO3: A comparative first-principles study
Ghosez, Philippe ULg; Cockayne, E.; Waghmare, U. V. et al

in Physical Review. B : Condensed Matter (1999), 60(2), 836-843

The full phonon dispersion relations of lead titanate and lead zirconate in the cubic perovskite structure are computed using first-principles variational density-functional perturbation theory, with nb ... [more ▼]

The full phonon dispersion relations of lead titanate and lead zirconate in the cubic perovskite structure are computed using first-principles variational density-functional perturbation theory, with nb initio pseudopotentials and a plane-wave basis set. Comparison with the results previously obtained for barium titanate shows that the change of a single constituent (Ba to Pb, Ti to Zr) has profound effects on the character and dispersion of unstable modes, with significant implications for the nature of the phase transitions and the dielectric and piezoelectric responses of the compounds. Examination of the interatomic force constants in real space, obtained by a transformation which correctly treats the long-range dipolar contribution, shows that most are strikingly similar, while it is the differences in a few key interactions which produce the observed changes in the phonon dispersions. These trends suggest the possibility of the transferability of force constants to predict the lattice dynamics of perovskite solid solutions. [less ▲]

Detailed reference viewed: 37 (3 ULg)
Peer Reviewed
See detailAdjuvant small field pelvic radiation for patients with high risk, stage IB lymph node negative cervix carcinoma after radical hysterectomy and pelvic lymph node dissection. A pilot study.
KRIDELKA, Frédéric ULg; Berg, D. O.; Neuman, M. et al

in Cancer (1999), 86(10), 2059-65

BACKGROUND: After radical hysterectomy and pelvic lymph node dissection, an identifiable subgroup of patients with International Federation of Gynecology and Obstetrics Stage IB lymph node negative cervix ... [more ▼]

BACKGROUND: After radical hysterectomy and pelvic lymph node dissection, an identifiable subgroup of patients with International Federation of Gynecology and Obstetrics Stage IB lymph node negative cervix carcinoma remains at high risk of pelvic recurrence. This study attempted to determine whether postoperative small field of pelvic radiation can improve the disease free survival (DFS) of this high risk group of patients without producing significant morbidity. METHODS: Between 1991 and 1995, after radical surgery, 25 patients with Stage IB lymph node negative cervix carcinoma were considered to be at high risk of pelvic recurrence on the basis of tumor dimension, depth of stromal invasion, and the presence of lymph-vascular space invasion. All had a score >/= 120 as determined by the Gynecologic Oncology Group (GOG) study. These patients received 50.4 gray of adjuvant radiation to a small central pelvic field and were followed prospectively. A Kaplan-Meier 5-year DFS curve was generated. A log rank analysis produced an estimated log rank P value (est P value) by comparing the 5-year DFS of the patients in the current study with the 5-year DFS of the corresponding high risk group of the GOG study (observation only). The morbidity of small field pelvic radiation was recorded. RESULTS: Among the 25 patients who received small field pelvic radiation, the mean GOG score was 166 (range, 120-263) and the mean follow-up was 32 months (range, 12-64 months). There was 1 recurrence (4%) recorded at 16 months. The log rank analysis demonstrated a significant improvement in the 5-year DFS for the group who received adjuvant small field pelvic radiation (est P value = 0.005) when compared with the DFS of the high risk GOG patients who were observed postoperatively. Four cases of minor morbidity were recorded: lymphedema (three cases) and mild rectal incontinence (one case). No major morbidity was reported. CONCLUSIONS: With low morbidity, adjuvant small field pelvic radiation appears to improve significantly the 5-year DFS of patients with high risk, lymph node negative Stage IB cervical carcinoma. However, this pilot study requires verification. [less ▲]

Detailed reference viewed: 40 (1 ULg)
Peer Reviewed
See detailEthnic Mobilisation and political participation in Europe
Martiniello, Marco ULg; Statham, P.

in Journal of Ethnic and Migration Studies (1999), 25(4),

Detailed reference viewed: 32 (10 ULg)
Full Text
Peer Reviewed
See detailCLF Based designs with robustness to dynamic input uncertainties
Jankovic, Mrdjan; Sepulchre, Rodolphe ULg; Kokotovic, Petar

in Systems & Control Letters (1999), 37

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailUn orteil douloureux
Vanhooteghem, Olivier ULg; Richert, Bertrand ULg; de LA BRASSINNE, Michel ULg

in Revue de Médecine Générale [=RMG] (1999), 16

Case story of a patient with a painfull sub-ungueal tumentia.

Detailed reference viewed: 102 (0 ULg)
Full Text
Peer Reviewed
See detailInvolvement of indole-3-acetic acid in the circadian growth of the first internode of Arabidopsis
Jouve, Laurent; Gaspar, Thomas ULg; Kevers, Claire ULg et al

in Planta (1999), 209(1), 136-142

The extension rate of the first inflorescence node of Arabidopsis was measured during light/dark or continuous light exposure and was found to exhibit oscillations which showed a circadian rhythmicity ... [more ▼]

The extension rate of the first inflorescence node of Arabidopsis was measured during light/dark or continuous light exposure and was found to exhibit oscillations which showed a circadian rhythmicity. Decapitation induced a strong inhibition of stem extension. Subsequent application of IAA restored growth and the associated extension-rate oscillations. In addition, IAA treatments, after decapitation, re-established the circadian rhythmicity visible in the intact plants during free run. This indicates that the upper zone of the inflorescence has a major influence on the extension rate of floral stems and implies a role for auxin. Application of N-(1-naphthyl)phthalamic acid, an IAA transport inhibitor, to an intact floral stem inhibited growth and the rhythmicity in the extension rate oscillations, indicating that IAA polar transport may play a role in the dynamics of stem elongation. Furthermore, IAA-aspartate application, after decapitation, did not restore growth and rhythmicity. Nevertheless, biochemical analysis of IAA and IAA-aspartate demonstrated circadian fluctuations of the endogenous levels of both compounds. These observations suggest that IAA metabolism is an essential factor in the regulation of the circadian growth rhythm of Arabidopsis floral stems. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailClinical evaluation of processing techniques for attenuation correction with 137Cs in whole-body PET imaging.
Benard, F.; Smith, R. J.; Hustinx, Roland ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1999), 40(8), 1257-63

Transmission scanning can be successfully performed with a 137Cs single-photon emitting point source for three-dimensional PET imaging. However, the attenuation coefficients provided by this method are ... [more ▼]

Transmission scanning can be successfully performed with a 137Cs single-photon emitting point source for three-dimensional PET imaging. However, the attenuation coefficients provided by this method are underestimated because of the energy difference between 662- and 511-keV photons, as well as scatter and emission contamination when the transmission data are acquired after injection. The purpose of this study was to evaluate, from a clinical perspective, the relative benefits of various processing schemes to resolve these issues. METHODS: Thirty-eight whole-body PET studies acquired with postinjection singles transmission scans were analyzed. The transmission images were processed and applied to the emission data for attenuation correction. Three processing techniques were compared: simple segmentation (SEG) of the transmission scan, emission contamination subtraction with scaling (ECS) of the resulting data to 511-keV attenuation coefficient values and a hybrid technique performing partial segmentation of some tissue densities on the ECS scan (THR). The corrected emission scans were blindly assessed for image noise, the presence of edge artifacts at the lung-soft-tissue interface and for overall diagnostic confidence using a semiquantitative scoring system. The count densities and the SDs in uniform structures were compared among the various techniques. The observations for each method were compared using a paired t test. RESULTS: The SEG technique produced images that were visually less noisy than the ECS method (P < 0.0001) and the THR technique, but at the expense of increased edge artifacts at the boundaries between the lungs and surrounding tissues. The THR technique failed to eliminate these artifacts compared with the ECS technique (P < 0.0001) but preserved the activity gradients in the hilar areas. The count densities (and thus, the standardized uptake values) were similar among the three techniques, but the SEG method tended to underestimate the activity in the lung fields and in chest tumors (slope = 0.79 and 0.94, respectively). CONCLUSION: For many clinical applications, SEG data remain an efficient method for processing 137Cs transmission scans. The ECS method produced noisier images than the other two techniques but did not introduce artifacts at the lung boundaries. The THR technique, more versatile in complex anatomic areas, allowed good preservation of density gradients in the lungs. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailThe belgian experience in unrelated donor bone marrow transplantation: identification of center experience as an important prognostic factor.
Dresse, Marie-Françoise ULg; Boogaerts, Marc; Vermylen, Christiane et al

in Haematologica (1999), 84(7), 637-42

BACKGROUND AND OBJECTIVE: We reviewed all unrelated donor bone marrow transplants (UDBMT) performed in Belgium up to December 1995 to identify prognostic factors for relapse, transplant-related mortality ... [more ▼]

BACKGROUND AND OBJECTIVE: We reviewed all unrelated donor bone marrow transplants (UDBMT) performed in Belgium up to December 1995 to identify prognostic factors for relapse, transplant-related mortality and survival. DESIGN AND METHODS: A total of 163 UDBMT were performed in 92 males and 71 females aged 1-55 (median 26) years. Patients were transplanted for ALL (n=35), AML (n=34), CML (n=51), other myeloid malignancies (n=14), SAA (n=21) or miscellaneous other diseases (n=8). Most patients had advanced disease; a few patients were in CR1 (n=10) or early chronic phase (CP) of CML (n=5). RESULTS: Overall survival at 5 yrs was 17% (95% confidence interval: 8-32%), but survival was significantly better for patients with non-malignant disorders (55% at 4 yrs). The relapse rate +/-SE was projected to be 40 (28-54)% at 5 yrs, 36 (20-56)% for standard-risk and 68 (43-85)% for high-risk malignancies (p=0.0029). There was no relapse in CML patients transplanted in 1st CP compared to 68% at 4 yrs with more advanced CML (p=0.0033). Grade II-IV acute graft-versus-host disease (aGVHD) occurred in 55% by day 100 and was strongly modulated by age, ranging from 41% in <20-yr-old to 80% in >40-yr-old patients (p=0. 0021). Transplant-related mortality (TRM) was projected to be 72 (52-87)% at 5 yrs including 2 very late deaths from lung fibrosis and secondary cancer. Main causes of death were original disease in 27, secondary malignancy in 2, GVHD in 28, interstitial pneumonia in 21, other infections in 19, and miscellaneous toxic causes in 21 patients. In multivariate analysis, the relapse rate was strongly dependent on the disease status (p=0.0029), TRM being significantly worse with older age (p=0.0049), and overall survival being significantly worse in more advanced disease (p=0.0006), after a second transplant (p=0.0166), in centers of smaller size (p=0.0316) and in older patients (NS). INTERPRETATION AND CONCLUSIONS: Although results have improved somewhat in recent years, UDBMT remains a procedure with a high TRM. UDBMT should be performed in patients with less advanced diseases and in centers with more experience, particularly in the treatment of adult patients. [less ▲]

Detailed reference viewed: 83 (6 ULg)
Full Text
Peer Reviewed
See detailLes nouveaux outils de l'amenagement forestier: l'exemple des systemes d'information geographique.
Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Revue Forestière Française (1999), 51(Numero special), 169-184

Forest managers have to collect, process and use huge amounts of data for analysis, planning or management purposes. Most of these data have a spatial component which make them useful for decision-making ... [more ▼]

Forest managers have to collect, process and use huge amounts of data for analysis, planning or management purposes. Most of these data have a spatial component which make them useful for decision-making. The development of information technology has given rise to specific tools for the processing of spatial data : Geographic Information Systems (GIS). The methodological improvements required to take full advantage of these tools in practical applications have not always followed the development of this technology. The main goal of this paper is to take stock of the potential for using GIS in forest management. The emphasis is on three questions : (i) what is a GIS, (ii) what is it useful for and (iii) how is it implemented ? [less ▲]

Detailed reference viewed: 106 (13 ULg)
Full Text
Peer Reviewed
See detail• Compte-rendu de l'ouvrage de Jean Gaudemet: Droit privé romain
Gerkens, Jean-François ULg

in Actualités du Droit (1999), (3), 558-559

Detailed reference viewed: 33 (9 ULg)
Full Text
Peer Reviewed
See detailThe incorporation of a non-natural amino acid (aza-tryptophan) may help to crystallize a protein and to solve its crystal structure. Application to bacteriophage lambda lysozyme.
Evrard, Christine ULg; Fastrez, Jacques; Declercq, Jean-Paul

in Acta Crystallographica Section D-Biological Crystallography (1999), D55

Until now, wild-type bacteriophage lambda lysozyme had been impossible to crystallize. This difficulty could be overcome by the replacement of the four tryptophan residues by azatryptophans. Analysis of ... [more ▼]

Until now, wild-type bacteriophage lambda lysozyme had been impossible to crystallize. This difficulty could be overcome by the replacement of the four tryptophan residues by azatryptophans. Analysis of the intermolecular and intramolecular contacts in this modification allows understanding of the differences in behaviour between the native and modified molecules. Furthermore, this mutation was very useful for the creation of new heavy-atom binding sites and for the solution of the non-crystallographic symmetry, which is extremely important for phase improvement. This procedure seems to be generally applicable, at least in the search for new possibilities for heavy-atom binding sites. [less ▲]

Detailed reference viewed: 16 (0 ULg)
See detailLoi de protection des malades mentaux. La mise en observation psychiatrqiue
Boxho, Philippe ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1999), 21

Detailed reference viewed: 42 (0 ULg)
Peer Reviewed
See detailComment j'explore ... le risque coronarien individuel extrapole a 10 ans.
Scheen, André ULg; Rorive, Georges ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1999), 54(2), 118-21

The European Societies of Cardiology. Atherosclerosis and Hypertension agreed upon a table allowing to evaluate the coronary risk after 10 years according to five parameters (sex, age, smoking, total ... [more ▼]

The European Societies of Cardiology. Atherosclerosis and Hypertension agreed upon a table allowing to evaluate the coronary risk after 10 years according to five parameters (sex, age, smoking, total cholesterol, arterial blood pressure) and aggravating factors (familial history, diabetes mellitus, low HDL cholesterol, hypertriglyceridaemia). The risk level is based upon the equations of the prospective US study of Framingham. The calculation of such a risk is mainly interesting before considering intensified primary prevention in an individual free of any cardiovascular disease. The efforts should first focus on individuals with a high coronary risk, i.e. > 20% after 10 years. As far as secondary prevention is concerned, the patients should always be considered at high risk and beneficiate of all available therapeutic means. [less ▲]

Detailed reference viewed: 37 (2 ULg)
Full Text
Peer Reviewed
See detailAdvective excess Ba transport as shown from sediment and trap geochemical signatures
Fagel, Nathalie ULg; André, Luc; Dehairs, Frank

in Geochimica et Cosmochimica Acta (1999), 63(16), 2353-2367

We report the results of a geochemical study of sediment and trap material. Major and trace elements (Zr, Ba, rare earth elements, and Th) were analyzed on bulk sedimentary material collected along the NE ... [more ▼]

We report the results of a geochemical study of sediment and trap material. Major and trace elements (Zr, Ba, rare earth elements, and Th) were analyzed on bulk sedimentary material collected along the NE Atlantic margin. Our aim is to test the widespread use of Ba-barite as a proxy for paleoproductivity in a continental margin area. This environment is of great interest because atmospheric-oceanic exchanges are important. In sediments, the geochemical signatures remain close to an upper crust reference, with flat shale-normalized rare earth elements patterns and constant elementary ratios. The calculated biogenic fraction of Ba or excess Pa (20-45%) remains lower than the excess Ba record in trap material (80-99%). The evolution of the geochemical signature along the margin reflects variable dilution of a detrital Post Archean Australian Shale-like component by a biogenic carbonaceous seawater-derived component. The trap material displays a wide range of variation in its trace element content (e.g., Ba similar to 150-3000 ppm, Zr similar to 2-100 ppm), except for the abyssal site, which is characterized by constant signature. In the two other sites, all of the trace element contents increase with water depth and present pronounced seasonal changes at each sampled water depth. The amount of excess Ba also increases in the deepest traps, and its evolution throughout the year mimics the change of the other analyzed trace elements. In contrast, its relationships with particulate organic carbon are not obvious. In term of fluxes, two periods of enhanced excess Ba fluxes are observed: (1) excess Pa flux increases with the detrital-like elements like Th especially during winter, and (2) excess Pa flux is enhanced without any change for the other trace elements during spring. To explain the first case, a supply through lateral advection is proposed. Such transient input of significant excess Ba flux will have a great impact on the yearly averaged estimation of the export production. Indeed, only the second case reflects a bloom in the biological productivity of the water column and must be taken into account in a mean calculation of the export production. Finally, a normalization of the excess Ba by detrital-like element like Th will help to discriminate between a real increase of the excess Ba due to local productivity change (high excess Ba and high excess Ba/Th ratio greater than or equal to 10,000) and any input due to advection process (high excess Ba but low excess Ba/Th ratio < 2000). Copyright (C) 1999 Elsevier Science Ltd. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Peer Reviewed
See detailPharma-clinics le medicament du mois. Le naratriptan (naramig).
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(3), 189-91

Naratriptan, launched by Glaxo Wellcome under the trade name Naramig, is a potent and selective agonist of 5-HT1B and 5-HT1D vascular receptors. Available as tablets of 2.5 mg, it is indicated in the ... [more ▼]

Naratriptan, launched by Glaxo Wellcome under the trade name Naramig, is a potent and selective agonist of 5-HT1B and 5-HT1D vascular receptors. Available as tablets of 2.5 mg, it is indicated in the acute treatment of migraine, with or without aura. A single oral dose of 2.5 mg naratriptan is characterized by a satisfactory clinical efficacy (already significant after one hour, maximum after 4 hours and persisting during 24 hours), a reduction by half of the recurrence of the migraine crisis within the 24 hours and an excellent tolerance profile. [less ▲]

Detailed reference viewed: 30 (0 ULg)
Full Text
Peer Reviewed
See detailUne tâche pigmentée suspecte
Vanhooteghem, Olivier ULg; Richert, Bertrand ULg; de LA BRASSINNE, Michel ULg

in Revue de Médecine Générale [=RMG] (1999), 166

What is your diagnosis for this periungual coloured spot of the thumb ?

Detailed reference viewed: 44 (0 ULg)
Full Text
Peer Reviewed
See detailWestward propagation of the North Anatolian fault into the northern Aegean: Timing and kinematics
Armijo, R.; Meyer, B.; Hubert, Aurelia ULg et al

in Geology (1999), 27

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the ... [more ▼]

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the finite displacement after, the passage of the propagating tip of the fault. The accuracy of the observations is due to interplay between deformation and the sea-level changes in the Mediterranean (the well-known Messinian regression followed by the Pliocene transgres- sion). The long-term kinematics around the Sea of Marmara pull-apart (total displacement of about 85 km over the past 5 m.y.) is similar to the present-day kinematics deduced from space geodesy. At a larger scale, westward propagation of the North Anatolian fault over nearly 2000 km in the past 10 m.y. appears to be associated with strain recovery, suggesting that the continental lithosphere retains long-term elasticity. [less ▲]

Detailed reference viewed: 22 (0 ULg)
See detailRôles de la structure et de la communication familiale
Born, Michel ULg; Helin, Dominique; Chevalier, V.

in JDJ (journal droit des jeunes) (1999)

Detailed reference viewed: 29 (6 ULg)
Full Text
Peer Reviewed
See detailDeactivation mechanisms and regeneration of a bimetallic hydrodechlorination catalyst
Heinrichs, Benoît ULg; Noville, Francis ULg; Schoebrechts, Jean-Paul et al

in Studies in Surface Science and Catalysis (1999), 126

The temporal evolution of the activity and selectivity of a 1.9%Pd-3.7%Ag/SiO2 catalyst during selective hydrodechlorination of 1,2-dichloroethane into ethylene is examined. A comparison between the ... [more ▼]

The temporal evolution of the activity and selectivity of a 1.9%Pd-3.7%Ag/SiO2 catalyst during selective hydrodechlorination of 1,2-dichloroethane into ethylene is examined. A comparison between the physico-chemical properties of the fresh catalyst and of the deactivated one suggests a deactivation mechanism by poisoning or coking of Ag sites at the surface of the active Pd-Ag particles. A regeneration treatment is proposed which allows to restore the initial properties of the fresh catalyst. [less ▲]

Detailed reference viewed: 30 (6 ULg)
Peer Reviewed
See detailPrivilège du bailleur, action en distraction et compétence du juge des saisies: questions croisées, note sous Liège (7e ch.), 25 nov. 1997
Georges, Frédéric ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

Detailed reference viewed: 92 (6 ULg)
Full Text
Peer Reviewed
See detailSPECT and PET imaging of brain tumors.
Hustinx, Roland ULg; Alavi, A.

in Neuroimaging Clinics of North America (1999), 9(4), 751-66

The unique capacity of measuring or visualizing intracellular biochemical processes allows nuclear medicine techniques to determine functional and metabolic activities of various disorders. This article ... [more ▼]

The unique capacity of measuring or visualizing intracellular biochemical processes allows nuclear medicine techniques to determine functional and metabolic activities of various disorders. This article describes the critical role of single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging of brain tumors beyond what can be achieved by anatomic methods. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Peer Reviewed
See detailA new database of astrophysical interest
Biémont, Emile ULg; Palmeri, P.; Quinet, Pascal ULg

in Astrophysics & Space Science (1999), 269-270

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detailAberglauben, Krankheit und das Böse. Exorzismus und Teufelsglaube im 18. und 19. Jahrhundert
Van den Bossche, Benoît ULg; Freytag, Niels

in Rheinisch-westfälische Zeitschrift für Volkskunde (1999), XLIV

Detailed reference viewed: 86 (5 ULg)
Full Text
See detailHet antigif. Maar is het nog op tijd?
Meesters, Gert ULg

in Over Taal (1999), 38(1), 35-36

Detailed reference viewed: 10 (2 ULg)
Peer Reviewed
See detailArtérite et coronarite post-radiques: a propos d'un cas
Vasquez, C.; Sakalihasan, Natzi ULg; Bonnet, Pierre ULg et al

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (1999), 11(3), 33-37

Detailed reference viewed: 70 (0 ULg)
Peer Reviewed
See detailA nouveau des questions sur les droits du C.P.A.S. à l'égard des débiteurs alimentaires
Paris, Catherine ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

Detailed reference viewed: 22 (0 ULg)
Full Text
Peer Reviewed
See detailRegulation of cancer invasion and vascularization by plasminogen activator inhibitor-1
Noël, Agnès ULg; Bajou, Khalid ULg; Masson, Véronique ULg et al

in Fibrinolysis and Proteolysis (1999), 13(6), 220-225

Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of ... [more ▼]

Acquisition of invasive/metastatic potential through protease expression is a key event in tumor progression. The proteolytic enzyme plasmin is generated from the precursor plasminogen by the action of urokinase-type plasminogen activator (urokinase, uPA) or tissue-type plasminogen activator (tPA). Plasminogen activator inhibitor-1 or PAI-1 is the main inhibitor of uPA and tPA. High levels of components of this proteolytic system, including uPA and its cell surface receptor (uPAR), have been correlated with a poor prognosis for different cancers. It was therefore anticipated that PAI-1 expression would be associated with favorable outcome. Paradoxically, high rather than low PAI-1 levels predict poor survival of patients suffering from a variety of cancers. Recent observations indicate a much more complex role of PAI-1 in tumor progression and angiogenesis than initially expected. The exact mechanisms of this multifunctional molecule remain puzzling. [less ▲]

Detailed reference viewed: 19 (7 ULg)
Full Text
Peer Reviewed
See detailGoverning biodiversity
Mougenot, Catherine ULg; Mormont, Marc ULg

in International Journal of Environment and Pollution (1999), 12(4), 78-99

he hypothesis of this paper is that the value conferred on nature designates both the ''objects of nature'' that are the subject of consideration, and the human beings for whom they are intended or who ... [more ▼]

he hypothesis of this paper is that the value conferred on nature designates both the ''objects of nature'' that are the subject of consideration, and the human beings for whom they are intended or who are responsible for them. These designation processes are dynamic and linked, but also interdependent. In order to examine these processes more closely, we make use of the concept of network, which integrates the action of different players in their specific world, as well as ''objects'' that can be as different as scientific nomenclatures, available sites, management plans, funds, etc. In other words, protection practices link up different universes, scientific models and practices, institutional practices, nature conservation practices and, finally, the evolution of species and natural sites that are not passive entities. The fact that we speak of ''socio-natural'' networks indicates that nature conservation is ''based'' on chains of equivalences that integrate these different players and universes. The processes are dynamic ones. The paper therefore examines how they can be stabilised or expanded, and also how they can be transformed in a much more radical manner. The study is applied to the Walloon Region (in Belgium). The paper first looks at what could be considered as the ''classical nature conservation network'', and then examines how it is called to evolve. The fact is that contemporary situations lead us to take account of different types of networks for conserving and maintaining nature. These are compared, and the paper examines how each of them attempts to take account of the increasingly complex and also increasingly open concept of biodiversity. This perspective of networking also leads us to conclude that none of these networks (scientific, economic, legislative, institutional, etc.) that go to make up nature conservation is capable on its own of giving value to nature. This is acquired - or not - only by building a hybrid chain that cuts across or integrates these different worlds. [less ▲]

Detailed reference viewed: 127 (53 ULg)
Full Text
Peer Reviewed
See detailImpairment of neuromuscular transmission in a subgroup of migraine patients
Ambrosini, Anna; MAERTENS DE NOORDHOUT, Alain ULg; Alagona, Giovanna et al

in Neuroscience Letters (1999), 276(3), 201-3

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura ... [more ▼]

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholine release. Using single fiber EMG recordings we were able to demonstrate subclinical abnormalities of neuromuscular transmission in a subgroup of patients suffering from migraine with aura. This could be related to genetic abnormalities of P/Q Ca2+ channels in certain patients suffering from migraine with aura, which needs to be explored by proper genetic analyses. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailProbabilistic design of power-system special stability controls
Wehenkel, Louis ULg; Lebrevelec, Cyril; Trotignon, Marc et al

in Control Engineering Practice (1999), 7(2), 183-194

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and ... [more ▼]

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and fast dynamics, and modeling uncertainties. A large number of scenarios are simulated in parallel by time-domain numerical integration, and the relevant parameters of the resulting system trajectories are stored in a database. Data-mining tools are used to identify the most important system weaknesses and possible improvements. The approach is tested on a large-scale study on the SouthÐEastern part of the extra-high-voltage system of Electricité de France. [less ▲]

Detailed reference viewed: 22 (3 ULg)
See detailHyperplasie bénigne de la prostate
Bonnet, Pierre ULg

in La revue de Médecine générale (1999), (161), 120-129

Detailed reference viewed: 11 (2 ULg)
See detailLa nouvelle procédure contentieuse en matière de taxes provinciales et communales
Orban, Lionel ULg

in Actualités du Droit (1999)

Detailed reference viewed: 36 (3 ULg)
See detailReproduction of Lesions and Clinical Signs with a Cnf2-Producing Escherichia Coli in Neonatal Calves
Van Bost, S.; Mainil, Jacques ULg

in Advances in Experimental Medicine and Biology (1999), 473

CNF2-producing necrotoxigenic E. coli (NTEC2) are associated with diarrhoea and septicaemia in calves. We orally inoculated neonatal calves with a NTEC2 strain in order to reproduce clinical signs and ... [more ▼]

CNF2-producing necrotoxigenic E. coli (NTEC2) are associated with diarrhoea and septicaemia in calves. We orally inoculated neonatal calves with a NTEC2 strain in order to reproduce clinical signs and lesions. We observed diarrhoea in each inoculated calf, bacteraemia (80%), the presence of CNF2+ bacteria in the lungs (80%) and in the liver (20%). The observed lesions were inflammation of the entire gut, hypertrophy of the mesenteric lymph nodes and hepatisation of the lungs. We were unable to detect characteristic lesions that are classical signs of septicaemia. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailIn vitro study of the interactions between bovine herpesvirus 4 and the bovine host cells
Vanderplasschen, Alain ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154

This work was devoted to the study of the interactions between bovine herpesvirus 4 (BHV-4) and bovine cells in vitro. It led to the discovery of two interesting properties of BVH-4 replication cycle ... [more ▼]

This work was devoted to the study of the interactions between bovine herpesvirus 4 (BHV-4) and bovine cells in vitro. It led to the discovery of two interesting properties of BVH-4 replication cycle: first, the cellular receptor heparan sulfate was proven to mediate BVH-4 binding to target cells. This is the first description of the implication of heparan sulfate in the binding process of a gammaherpesvirus. Second, using synchronised cells, the replication of BVH-4 DNA was proven to be dependent on the S phase of the cell cycle. This dependence could explain some properties of BVH-4 infection in vitro and could play an important role in the biology of the infection in vivo. Finally, in order to produce monoclonal antibodies against BVH-4 IE1 and IE2 proteins, the genes coding for these proteins were cloned and expressed in prokaryotic cells. [less ▲]

Detailed reference viewed: 1 (0 ULg)