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See detailSynchronization of estrus in goats: the relationship between PMSG binding in plasma, time of occurrence of estrus and fertility following artificial insemination
Baril, G.; Remy, Benoît ULg; Leboeuf, J. F. et al

in Theriogenology (1996), 45(8), 1553-1559

Radioimmunoassay (RIA) was used to measure plasma eCG binding in dairy goats (n = 524) at the beginning of a progestagen/eCG treatment and 25 d after eCG administration. The eCG binding was not dependent ... [more ▼]

Radioimmunoassay (RIA) was used to measure plasma eCG binding in dairy goats (n = 524) at the beginning of a progestagen/eCG treatment and 25 d after eCG administration. The eCG binding was not dependent on the age of the females but increased with the number of treatments they had previously received (3.4 % ± 4.8, N = 47 vs 9.6 % ± 13.2, N = 249; mean ± SD; P < 0.01 for goats treated 0 and 1 time vs those treated 2 to 5 times, respectively). The synchronization treatment led to an increase in the binding of eCG (7.1 % ± 10.9 before vs 28.3 ± 24.5 after treatment; P < 0.01). When eCG binding before treatment was higher than 5 % the onset of estrus was delayed: 37.9 % of goats came into estrus more than 30 h after sponge removal vs 7.4 % when eCG binding was lower than 5 % (P < 0.01). Fertility was significantly decreased when eCG binding was higher than 10 %. These results show that the repetition of treatment with eCG to induce estrus in goats increases eCG binding. This could explain the lowered efficiency of the hormonal treatment to synchronize estrus and the associated decrease in fertility when goats are inseminated at a predetermined time. [less ▲]

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See detailLa dissection aortique. Des symptômes a l'indication opératoire
Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1996), 51(6), 411-25

La formation d'un hématome au sein de la média aortique à partir d'un orifice d'entrée définit la dissection aortique qui se caractérise par la présence de deux lumières aortiques: la vraie et la fausse ... [more ▼]

La formation d'un hématome au sein de la média aortique à partir d'un orifice d'entrée définit la dissection aortique qui se caractérise par la présence de deux lumières aortiques: la vraie et la fausse. Toute altération structurelle de la média (hypertension, médianécrose, maladie de Marfan, etc...) favorise la dissection. Le début de l'affection est brutal, avec un tableau polymorphe fait de douleurs intenses et migrantes, d'abolition du pouls dans certains territoires, voire d'une insuffisance aortique d'installation rapide. A partir des signes cliniques, le diagnostic est confirmé par des examens complémentaires (échographie, CT-scanner, résonance magnétique nucléaire, artériographie). L'échographie réalisée par voie transoesophagienne tend actuellement à constituer l'examen de premier choix. Dans les dissections qui concernent l'aorte ascendante (types 1, II et III rétrograde de DeBakey, ou type A de Stanford), une chirurgie rapide est impérative en raison de la fréquence des complications mortelles (rupture dans le péricarde avec tamponnade, ischémie myocardique par dissection des coronaires, insuffisance aortique massive avec défaillance ventriculaire gauche). L'intervention consiste à remplacer l'aorte ascendante en conservant ou non la valvule aortique; si l'on implante la prothèse artérielle sur l'annulus aortique, on doit procéder à la réimplantation des coronaires selon la technique de Bentall ou de Cabrol. En cas de dissection qui respecte l'aorte ascendante et ne concerne que l'aorte thoracique descendante (type III a ou b de DeBakey ou type B de Stanford), un traitement médical est d'abord instauré et la chirurgie, qui consiste à remplacer un segment plus ou moins long de l'aorte descendante, n'est appliquée qu'en cas de complications (rupture imminente avec formation d'un épanchement pleural, persistance des douleurs, ischémie viscérale, hypertension incontrôlable). Le traitement médical a pour but de diminuer les douleurs et repose sur l'induction d'une hypotension contrôlée et d'une dépression de la contractilité myocardique; ceci ralentit la vitesse d'établissement de l'onde de pression artérielle, qui constitue le moteur de la dissection. Ce traitement médical doit être instauré avant la chirurgie, après la chirurgie s'il y a lieu de la réaliser, et au long cours une fois le patient sorti de l'hôpital. [less ▲]

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See detailPercutaneous Balloon Pericardiotomy: A Case Report and Analysis of Mechanism of Action
Bertrand, O.; Legrand, Victor ULg; Kulbertus, Henri ULg

in Catheterization and Cardiovascular Diagnosis (1996), 38(2), 180-2

A 33-year-old man with acquired immunodeficiency syndrome (AIDS) and cardiac tamponade underwent percutaneous balloon pericardiotomy. To elucidate the pathway of fluid elimination, at the end of the ... [more ▼]

A 33-year-old man with acquired immunodeficiency syndrome (AIDS) and cardiac tamponade underwent percutaneous balloon pericardiotomy. To elucidate the pathway of fluid elimination, at the end of the procedure, we injected methylene blue into the pericardial space. Contrary to previous belief, we found no blue discoloration of the pleural fluids, and thus we postulate that most of the fluid was eliminated by peritoneal resorption. [less ▲]

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See detailParasympathetic component of 5-hydroxytryptamine-induced pulmonary dysfunctions in health calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1996), 57(6), 896-901

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See detailSodium Valproate in Severe Migraine and Tension-Type Headache: An Open Study of Long-Term Efficacy and Correlation with Blood Levels
Lenaerts, M.; Bastings, E.; Sianard, J. et al

in Acta Neurologica Belgica (1996), 96(2), 126-9

We performed an open prospective study of the prophylactic efficacy of sodium valproate in 56 patients among which 35 migraineurs, 7 chronic tension-type headache patients and 14 patients with combined ... [more ▼]

We performed an open prospective study of the prophylactic efficacy of sodium valproate in 56 patients among which 35 migraineurs, 7 chronic tension-type headache patients and 14 patients with combined headaches. We compared the mean number of headache days per month during a one-month-baseline period without prophylactic treatment and during the last month of a 6-month-treatment course. Among secondary parameters, we assessed headache intensity, adverse experiences and we measured valproate blood levels after one and after six months of treatment. Sixty percent of migraineurs had a 75% or more improvement in the number of headache days under sodium valproate, most of the remaining attacks being less severe. There was no significant improvement in chronic tension-type headache patients and only a mild effect in patients with combined headaches, almost exclusively on the migraine component. Thirty percent of patients reported adverse effects of which none was serious: there were 3 drop-outs. We found a moderate, but statistically significant, correlation between efficacy and blood levels of sodium valproate. [less ▲]

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See detailInteractions between endothelial cells and smooth muscle cells after their activation by hypoxia. A possible etiology for venous disease.
Michiels, C.; Arnould, T.; Janssens, D. et al

in International Angiology : A Journal of the International Union of Angiology (1996), 15(5), 124-130

Because of their localization at the interface between blood and tissue, endothelial cells are responsible for the maintenance of vascular homeostasis. They fulfil a series of various functions and ... [more ▼]

Because of their localization at the interface between blood and tissue, endothelial cells are responsible for the maintenance of vascular homeostasis. They fulfil a series of various functions and constantly interact with circulating leukocytes and with the smooth muscle cells (SMC) present in the media. Any disturbance of their metabolism can thus lead to alterations of the blood vessel functions. We have shown that hypoxia, for example resulting from venous stasis, induces the activation of endothelial cells which then release inflammatory mediators able to activate neutrophils and to induce their infiltration as well as growth factors for SMC. We propose that these processes are the beginning of a cascade of events eventually leading to structural and functional modifications of the venous wall similar to the ones observed in varicose vein wall. The endothelium alterations resulting from venous stasis would thus be the origin of the development of the venous disease. Pharmacological and clinical evidence reinforce this hypothesis. [less ▲]

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See detailAn empirical formula to estimate the resistance of a convoy in a restricted waterway
Marchal, Jean ULg; Shen, Yide ULg

in Marine Technology and SNAME News (1996), volume 40(2), 107-112

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See detailContribution of polyalky(meth)acrylates to the design of PVC melt viscosity
Vankan, R.; Fayt, Roger; Jérôme, Robert ULg et al

in Polymer Engineering & Science (1996), 36(12), 1675-1684

The shear viscosity of poly(vinylchloride) (PVC) at 200°C can be decreased by at least one order of magnitude by the addition of as little as 5 wt% poly n-alkyl-(meth)acrylates (PMA) of a much lower ... [more ▼]

The shear viscosity of poly(vinylchloride) (PVC) at 200°C can be decreased by at least one order of magnitude by the addition of as little as 5 wt% poly n-alkyl-(meth)acrylates (PMA) of a much lower dynamic viscosity than PVC. For this effect to be observed, the polymeric additive must be immiscible with PVC at 200°C. The average size of the dispersed phases is observed in the range of 0.5 to 5 m; size fluctuation in this domain has no significant effect. When these conditions are met, there is a linear increase in the shear viscosity ratio blend/PVC from 0.2 to 1.0 with increasing logarithmic values of the dynamic viscosity ratio of the additive over PVC [(log(/)) from -4 to -1]. [less ▲]

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See detailFrontal lobe dementia presenting as personality disorder
Salmon, Eric ULg; Degueldre, Christian ULg; Franco, Gianni ULg et al

in Acta Neurologica Belgica (1996), 96(2), 130-134

The early differential diagnosis of frontal lobe dementia is particularly difficult because changes of personality or behaviour overwhelm intellectual and cognitive impairments. We report the case of a ... [more ▼]

The early differential diagnosis of frontal lobe dementia is particularly difficult because changes of personality or behaviour overwhelm intellectual and cognitive impairments. We report the case of a patient presenting with paranoid personality disorder who refused to collaborate in neuropsychological testing. Initial functional imaging showed frontal hypometabolism that served as an early marker of frontal lobe dysfunction. [less ▲]

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See detailDetection of Hoxa1 Expression in Human Breast Cancer
Chariot, Alain ULg; Castronovo, Vincenzo ULg

in Biochemical and Biophysical Research Communications (1996), 222(2), 292-7

Homeodomain-containing proteins are transcription factors that regulate the coordinated expression of multiple genes involved in development, differentiation and malignant transformation. To better ... [more ▼]

Homeodomain-containing proteins are transcription factors that regulate the coordinated expression of multiple genes involved in development, differentiation and malignant transformation. To better understand the role played by these proteins in breast cancer cells, we demonstrate, using semi-quantitative RT-PCR experiments, that progestin induces HOXA1 mRNAs in MCF7 cells. This is the first evidence of regulation of a HOX gene by steroids. Moreover, we detected HOXA1 expression in a variety of human breast cancer lesions, suggesting that HOXA1 may be required for the establishment of breast cancer cells phenotype. We propose that HOXA1 gene could be one of the orchestrators that regulate breast epithelial cell differentiation and that alteration of HOXA1 expression could play a role in breast cancer progression. [less ▲]

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See detailSynthesis and preliminary characterization of model liquid crystalline ionomers
Gohy, Jean-François; Vanhoorne, Pierre ULg; Jérôme, Robert ULg

in Macromolecules (1996), 29(10), 3376-3383

Model liquid crystalline ionomers have been synthesized that consist of low molecular weight linear chains selectively end-capped at one or both end(s) with an ionic mesogenic group. ω- and α,ω ... [more ▼]

Model liquid crystalline ionomers have been synthesized that consist of low molecular weight linear chains selectively end-capped at one or both end(s) with an ionic mesogenic group. ω- and α,ω-carboxylato and sulfonato polystyrene chains have been prepared by living anionic polymerization and associated with mesogenic counterions, the structure of which is a rigid azobenzene moiety attached to a quaternary ammonium halide through a flexible spacer. The thermotropic behavior of the liquid crystalline halato(semi)telechelic polymers (LC H(S)TP's) has been studied by differential scanning calorimetry and optical microscopy. Some of them show smectic mesophases in a large temperature range. Actually, the liquid crystalline properties of the LC H(S)TP's depend on the molecular weight and the nature of the ionic end groups. A model, based on a crystal close packing approach, shows that the bulkiness of the sulfonato end groups can prevent the formation of smectic mesophases. The supramolecular organization of the LC H(S)TP's has also been studied by small angle neutron scattering, which agrees with a microphase separation between the polymer chains and the mesogenic counterions. [less ▲]

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See detailPolyimide nanofoams from caprolactone-based copolymers
Hedrick, James L; Russell, T. P.; Sanchez, M. et al

in Macromolecules (1996), 29(10), 3642-3646

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See detailAp stars periodicity (Catalano+ 1997)
Catalano, F. A.; Renson, Pierre ULg

in VizieR Online Data Catalog (1996), 412

New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before ... [more ▼]

New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before but it was not reported in previous issues of this catalogue. For many stars also present in previous issues of the catalogue new determinations of the periods are given. Recently attributed variable star names are also quoted. Note: this catalog is included in <III/199> (2 data files). [less ▲]

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See detailDecreased expression of galectin-3 is associated with progression of human breast cancer.
Castronovo, Vincenzo ULg; van den Brule, Frédéric; Jackers, Pascale ULg et al

in Journal of Pathology (The) (1996), 179(1), 43-48

Galectin-3, a member of the beta-galactoside-binding lectin family, is involved in several biological events including binding to the basement membrane glycoprotein laminin. Although the exact role of ... [more ▼]

Galectin-3, a member of the beta-galactoside-binding lectin family, is involved in several biological events including binding to the basement membrane glycoprotein laminin. Although the exact role of galectin-3 during the interactions between cells and laminin is not yet known, it has recently been observed that its expression is down-regulated at both the protein and the mRNA level in colon cancer tissues in correlation with progression of the disease. This study investigated the possibility that breast cancer cells might also exhibit decreased galectin-3 expression in association with their aggressiveness. The expression of galectin-3 was examined by immunoperoxidase staining, using a polyclonal antibody raised against recombinant galectin-3, in a collection of 98 human breast lesions including 12 fibroadenomas, 15 fibrocystic disease lesions, 22 in situ carcinomas, and 49 infiltrating ductal carcinomas, 19 of which had positive axillary lymph nodes. Normal breast tissue adjacent to the lesions was present in 59 biopsies. Normal breast tissue expressed high levels (3+) of galectin-3. High expression (2+ to 3+) was also found in most benign lesions examined. The expression of galectin-3 was significantly decreased in in situ carcinoma and this down-regulation was more pronounced in invasive ductal carcinoma, particularly when associated with infiltration of axillary lymph nodes. These data constitute the first observation that galectin-3 is down-regulated in breast cancer and suggest the decreased expression of this galactoside-binding lectin is associated with the acquisition of the invasive and metastatic phenotype. [less ▲]

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See detailIntensity Dependence of Auditory Evoked Potentials Is Pronounced in Migraine: An Indication of Cortical Potentiation and Low Serotonergic Neurotransmission?
Wang, W.; Timsit-Berthier, M.; Schoenen, Jean ULg

in Neurology (1996), 46(5), 1404-9

Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between ... [more ▼]

Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy volunteers. Binaural tones were delivered at 40, 50, 60, and 70 dB sensation level (SL) in a pseudorandomized order. The intensity dependence of the auditory N1-P2 component was significantly greater in MO (p = 0.003) and MA (p = 0.02) patients than in healthy controls, resulting in a much steeper amplitude/stimulus intensity function slope. When three sequential blocks of 40 averaged responses were analyzed at the 40- and 70-dB SL intensities, N1-P2 amplitude decreased in second and third blocks at both intensities in controls, but increased in migraineurs, a difference that was significant in both blocks for the 70-dB SL stimulus. The strong interictal dependence of AEPs on stimulus intensity may thus be due to potentiation (instead of habituation) of the response during repetition of the high-intensity stimulation. In concordance with previous studies of visual evoked potentials, these results confirm that migraine is characterized between attacks by an abnormality of cortical information processing, which might be a consequence of low 5-HT transmission and favor cortical energy demands. [less ▲]

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See detailBone Sialoprotein Expression in Primary Human Breast Cancer Is Associated with Bone Metastases Development
Bellahcene, Akeila ULg; Kroll, M.; Liebens, F. et al

in Journal of Bone and Mineral Research (1996), 11(5), 665-70

Breast cancer metastasizes to bone more frequently than to any other organ, and over 80% of advanced breast cancer patients develop bone metastases. Our recent demonstration that human breast cancer cells ... [more ▼]

Breast cancer metastasizes to bone more frequently than to any other organ, and over 80% of advanced breast cancer patients develop bone metastases. Our recent demonstration that human breast cancer cells express bone sialoprotein (BSP), a bone matrix protein, provides a possible clue for the selective affinity of breast cancer cells for bone. We tested the hypothesis that detection of BSP in primary human breast cancer could be a potential indicator of the ability of breast cancer cells to metastasize to bone. BSP expression was evaluated in the primary breast cancers of 39 patients using immunoperoxidase and two specific anti-BSP antibodies. None of these patients presented clinically or scintigraphically detectable bone metastases at the time of surgery. In the course of their disease, 22 patients developed clinically diagnosed bone metastases. Expression of BSP in breast cancer cells from patients who developed bone metastases was significantly higher (p = 0.008, according to the Mann-Whitney test) than in patients with no bone involvement. No association was found between BSP expression in the primary breast lesions and axillary lymph node metastases. BSP expression was significantly increased in infiltrating ductal carcinoma compared with infiltrating lobular carcinoma (p = 0.0023). No correlation was found between immunoreactivity to BSP antibodies and estrogen receptor (ER) status, progesterone receptor (PR) status, or age. Our data suggest that BSP could help to identity which women will develop bone metastases and provide new bases for the understanding of the molecular mechanism(s) responsible for breast cancer cells osteotropism. [less ▲]

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See detailAndrew Bennett, 'Keats, Narrative and Audience: The Posthumous Life of Writing'
Steyaert, Kris ULg

in Romanticism on the Net (RoN) (1996), 1(2),

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See detailTheoretical investigation of the molecular structure of aluminium triisopropoxide and its complexes in ring-opening polymerization
Parenté, Vincent; Brédas, Jean-Luc; Dubois, Philippe ULg et al

in Macromolecular Theory and Simulations (1996), 5(3), 525-546

We present a theoretical study on aluminium triisopropoxide (Al(O1Pr)3) using both empirical (Molecular Mechanics, MM, with Dreiding II force field) and quantum-chemical (Austin Model 1, AMI ... [more ▼]

We present a theoretical study on aluminium triisopropoxide (Al(O1Pr)3) using both empirical (Molecular Mechanics, MM, with Dreiding II force field) and quantum-chemical (Austin Model 1, AMI, semiempirical Hartree-Fock) techniques. We determine the most stable geometries for both the tetramer and tiimer of aluminium triisopropoxide as well as the thermodynamic characteristics of the equilibrium existing between these two aggregated structures. The theoretical results are compared to experimental data from X-ray diffraction and 27Al NMR measurements. For the tetramer, it appears that the optimal equilibrium geometries are in good agreement with the experimental X-ray diffraction geometry; another geometry is also obtained with both theoretical approaches, which is slightly less stable but of higher symmetry. On the basis of the most stable configurations for the tetramer and trimer aggregates, the variation of free enthalpy (AG) between the two aggregated structures has been estimated. The evolution of the theoretical AG values indicates a displacement of equilibrium towards the trimer species with temperature, in good agreement with experimental 1H and 27Al NMR data. Moreover, the AMI heats of formation show a gain of 33.9 kcal/mol due to the aggregation of four Al(O1Pr)3 instead of three, and thus a better stability of the tetramer. The molecular geometries being well described by the theoretical methods used in this study, we also present a model for the ring-opening polymerization complexes of ε-caprolactone and lactides. [less ▲]

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See detailEffects of Ingested Fructose and Infused Glucagon on Endogenous Glucose Production in Obese Niddm Patients, Obese Non-Diabetic Subjects, and Healthy Subjects
Paquot, Nicolas ULg; Schneiter, P.; Jequier, E. et al

in Diabetologia (1996), 39(5), 580-6

Increased endogenous glucose production (EGP) and gluconeogenesis contribute to the pathogenesis of hyperglycaemia in non-insulin-dependent diabetes mellitus (NIDDM). In healthy subjects, however, EGP ... [more ▼]

Increased endogenous glucose production (EGP) and gluconeogenesis contribute to the pathogenesis of hyperglycaemia in non-insulin-dependent diabetes mellitus (NIDDM). In healthy subjects, however, EGP remains constant during administration of gluconeogenic precursors. This study was performed in order to determine whether administration of fructose increases EGP in obese NIDDM patients and obese non-diabetic subjects. Eight young healthy lean subjects, eight middle-aged obese NIDDM patients and seven middle-aged obese non-diabetic subjects were studied during hourly ingestion of 13C fructose (0.3 g.kg fat free mass-1.h-1) for 3 h. Fructose failed to increase EGP (measured with 6,6 2H glucose) in NIDDM (17.7 +/- 1.9 mumol.kg fat free mass-1.min-1 basal vs 15.9 +/- 0.9 after fructose), in obese non-diabetic subjects (12.1 +/- 0.5 basal vs 13.1 +/- 0.5 after fructose) and in lean healthy subjects (13.3 +/- 0.5 basal vs 13.8 +/- 0.6 after fructose) although 13C glucose synthesis contributed 73.2% of EGP in lean subjects, 62.6% in obese non-diabetic subjects, and 52.8% in obese NIDDM patients. Since glucagon may play an important role in the development of hyperglycaemia in NIDDM, healthy subjects were also studied during 13C fructose ingestion + hyperglucagonaemia (232 +/- 9 ng/l) and during hyperglucagonaemia alone. EGP increased by 19.8% with ingestion of fructose + glucagon (p < 0.05) but remained unchanged during administration of fructose or glucagon alone. The plasma 13C glucose enrichment was identical after fructose ingestion both with and without glucagon, indicating that the contribution of fructose gluconeogenesis to the glucose 6-phosphate pool was identical in these two conditions. We concluded that during fructose administration: 1) gluconeogenesis is increased, but EGP remains constant in NIDDM, obese non-diabetic, and lean individuals; 2) in lean individuals, both an increased glucagonaemia and an enhanced supply of gluconeogenic precursors are required to increase EGP; this increase in EGP occurs without changes in the relative proportion of glucose 6-phosphate production from fructose and from other sources (i.e. glycogenolysis + gluconeogenesis from non-fructose precursors). [less ▲]

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See detailChanges in the Concentrations of Auxins and Polyamines During Rooting of in-Vitro-Propagated Walnut Shoots
Heloir, Marie-Claire; Kevers, Claire ULg; Hausman, Jean-François et al

in Tree Physiology (1996), 16(5), 515-9

Rooting was induced in in-vitro-propagated walnut (Juglans regia L.) shoots by subculturing the shoots on rooting medium containing agar and 3 mg l(-1) indole-3-butyric acid (IBA) for 7 days in darkness ... [more ▼]

Rooting was induced in in-vitro-propagated walnut (Juglans regia L.) shoots by subculturing the shoots on rooting medium containing agar and 3 mg l(-1) indole-3-butyric acid (IBA) for 7 days in darkness. Changes in the concentrations of endogenous free indole-3-acetic acid (IAA), indole-3-acetylaspartic acid (IAAsp) and free polyamines were determined during culture on root-inducing medium. In extracts of whole shoots, the concentration of free IAA showed a transient peak at 60 h (around 48 h in extracts from basal shoot portions) and then remained at a relatively low concentration for the remainder of the 7-day culture period. The concentration of IAAsp in extracts of whole shoots peaked at about the same time as the concentration of free IAA, whereas the IAAsp concentration in extracts from basal shoot portions peaked earlier, at around 12 h. The concentrations of free polyamines in extracts of whole shoots increased soon after the shoots were transferred to root-inducing medium. The concentrations of IAA and IAAsp remained stable when the rooted shoots were transferred to a vermiculite/gelrite mixture (without auxin) and grown in light. [less ▲]

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See detailCardiovascular response to exogenous serotonin in healthy calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1996), 57(5), 731-738

OBJECTIVE: To characterize the cardiovascular response to i.v. administration of serotonin (5-hydroxytryptamine [5-HT]) in calves. ANIMALS: 5 healthy unsedated Friesian calves. PROCEDURE: 41 5-HT ... [more ▼]

OBJECTIVE: To characterize the cardiovascular response to i.v. administration of serotonin (5-hydroxytryptamine [5-HT]) in calves. ANIMALS: 5 healthy unsedated Friesian calves. PROCEDURE: 41 5-HT administrations were performed: II slow infusions (duration, 5 minutes) and 30 bolus infusions (duration, 5 seconds). Cardiovascular function values were recorded before, during, and after the infusion. RESULTS: Slow infusion of 5HT first resulted in a brief period of severe bradycardia, then in sustained tachycardia with a concomitant increase in cardiac output. Systemic initial hypotension concomitant with bradycardia, then a pressor phase associated with an increase in systemic vascular resistance, and finally, a long-lasting hypotensive phase associated with decreased systemic vascular resistance. Pulmonary hypertension was associated with increased pulmonary vascular resistance, reflecting intense pulmonary vasoconstriction. Bolus infusion at increasing dosages resulted in dose-dependent bradycardia and systemic hypotension, followed by dose-dependent systemic hypertension. Unlike with slow infusion, neither the second tachycardiac nor the third systemic hypotensive phases were evident. CONCLUSIONS: 5-HT induces dose-dependent cardiovascular responses, including a reflex response followed by pulmonary and systemic vasoconstriction, in healthy calves. CLINICAL RELEVANCE: Determining the type of serotonergic receptors responsible for these responses may help to determine whether 5-HT is involved in the mechanisms underlying brisket disease in cattle. [less ▲]

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See detailCombined study of cerebral glucose metabolism and [11C] methionine accumulation in probable Alzheimer's disease using positron emission tomography
Salmon, Eric ULg; Grégoire, M. C.; Delfiore, Guy et al

in Journal of Cerebral Blood Flow & Metabolism (1996), 16(3), 399-408

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result ... [more ▼]

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result from local neuronal loss or from a decrease of synaptic activity. We measured in vivo [11C]methionine accumulation into proteins with positron emission tomography (PET) to assess cortical tissue loss in AD. Both global regional activity and compartmental analysis were used to express [11C]methionine accumulation into brain tissue. Glucose metabolism was measures with [18F]fluorodeoxyglucose and autoradiographic method. Combined studies were performed in 10 patients with probable AD, compared to age-matched healthy volunteers. There was a significant 45% decrease of temporo-parietal glucose metabolism in patients with AD, and frontal metabolism was lowered in most patients. Temporo-parietal metabolism correlated to dementia severity. [11C]methionine incorporation into temporo-parietal and frontal cortices was not significantly decreased in AD. There was no correlation with clinical symptoms. Data suggest that regional tissue loss, assessed by the decrease of [11C]methionine accumulation, is not sufficient to explain cortical glucose hypometabolism, which reflects, rather, reduced synaptic connectivity. [less ▲]

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See detailOxidative Stress in Clinical Situations--Fact or Fiction?
Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in European Journal of Anaesthesiology (1996), 13(3), 219-34

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See detailLibre circulation des capitaux: jurisprudence récente et perspectives
Partsch, Philippe-Emmanuel ULg

in Journal des Tribunaux Droit Européen (1996)

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See detailHemodynamic Responses to Pasteurella Haemolytica Inoculation in Calves Given Type 2 Serotonergic Antagonist
Desmecht, Daniel ULg; Linden, Annick ULg; Amory, Hélène ULg et al

in Canadian Journal of Physiology & Pharmacology (1996), 74(5), 572-9

The effects of saline (control, group C) and metrenperone (treated, group M) on systemic and pulmonary hemodynamics were determined in conscious 7- to 15-day-old calves after they were intratracheally ... [more ▼]

The effects of saline (control, group C) and metrenperone (treated, group M) on systemic and pulmonary hemodynamics were determined in conscious 7- to 15-day-old calves after they were intratracheally inoculated with Pasteurella haemolytica. Metrenperone, a specific serotonin (5-hydroxytryptamine) receptor antagonist, was injected intramuscularly (100 micrograms.kg-1) 2 h after the calves were inoculated. Central venous, pulmonary arterial and capillary wedge, and systemic arterial pressures were measured, using fluid-filled catheters. Cardiac output was measured by the thermodilution technique. Heart rate, stroke volume, and pulmonary and systemic vascular resistances were calculated. The parameters were measured hourly from the 1st to the 10th h after inoculation. In group C, cardiovascular response to P. haemolytica inoculation was marked and typically consisted of two systemic hypotensive phases and two pulmonary hypertensive phases. The first phase occurred by the 2nd h post inoculation and was induced by a transient bradycardia and a systemic vasodilation, leading to profound hypotension and reduced venous return. Cardiac performance then transiently recovered, but systemic hypotension persisted. The second hypotensive hypodynamic phase occurred by the 7th h after inoculation, and was associated with a decline in stroke volume, an increase in heart rate, and pulmonary hypertension and vasoconstriction. In group M, the early response to P. haemolytica exposure was similar to that in controls, indicating that, as in sheep, 5-hydroxytryptamine does not contribute to the early hypodynamic response to endotoxemia. In contrast, metrenperone completely abolished late increases in pulmonary arterial pressure and pulmonary vascular resistance, suggesting that 5-hydroxytryptamine contributes to the late pulmonary vasoconstriction. Metrenperone treatment also allowed better restoration of heart rate, and hence, cardiac output was maintained. In conclusion, 5-hydroxytryptamine might have a role in mediating pasteurellic endotoxin induced changes in pulmonary hemodynamics through its type-2 receptors. [less ▲]

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See detailEnzyme immobilization in reactive nanoparticles produced by inverse microemulsion polymerization
Daubresse, Catherine; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Colloid and Polymer Science (1996), 274(5), 482-489

This paper deals with the immobilization of alkaline phosphatase by physical entrapment within colloidal particles produced by inverse microemulsion polymerization. Functionality has been imparted to the ... [more ▼]

This paper deals with the immobilization of alkaline phosphatase by physical entrapment within colloidal particles produced by inverse microemulsion polymerization. Functionality has been imparted to the nanoparticle surface by copolymerization of acrylamide (the main monomer), N,N'-methylene-bis-acrylamide (the cross-linking agent) with either N-acryloyl-l,6-diamino-hexane (an amine promoter) or acrylic acid (a carboxylic acid promoter). The effect of the functions comonomers on the size and zeta potential of the reactive latexes has been studied. Integrity of the immobilized enzyme has been ascertained from its catalytic activity towards hydrolysis of p-nitrophenyl-phosphate. [less ▲]

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See detailSystèmes d'aide à la décision en gestion forestière
Lejeune, Philippe ULg; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Agricontact (1996), (282), 1-5

La planification et l'aménagement forestiers sont des activités qui nécessitent la prise en compte d'une quantité importante d'informations de natures variées entre autres écologiques, économiques et ... [more ▼]

La planification et l'aménagement forestiers sont des activités qui nécessitent la prise en compte d'une quantité importante d'informations de natures variées entre autres écologiques, économiques et sociales. Cette diversité d'informations, combinée à la multiplicité et l'interaction des échelles de référence spatiale (arbre, parcelle, massif, région) ou temporelle (court, moyen ou long terme) à considérer imposent la mise en oeuvre d'outils spécifiques d'aide à la décision capables d'intégrer ces contraintes et de maîtriser la complexité des processus à gérer. L'objectif des lignes qui suivent est de faire le point sur les systèmes d'aide à la décision (SAD) appliqués à la gestion forestière et de décrire les principaux outils que ceux-ci mettent habituellement en oeuvre. Après une définition des SAD et une description succincte de leurs constituants, nous envisagerons l'application de ces outils successivement au niveau local d'une parcelle, au niveau plus général d'une propriété forestière, avant de conclure sur les possibilités d'application de ces techniques dans le cadre de la gestion de forêts semblables à celles rencontrées en Belgique. [less ▲]

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See detailField Efficacy of Moxidectin 0.5% Pour-on against Chorioptes Bovis, Damalinia Bovis, Linognathus Vituli and Psoroptes Ovis in Naturally Infected Cattle
Losson, Bertrand ULg; Lonneux, J. F.

in Veterinary Parasitology (1996), 63(1-2), 119-30

Field efficacy of a pour-on formulation of moxidectin, a macrocyclic lactone endectocide, was evaluated in cattle naturally infested with Chorioptes bovis, Damalinia bovis, Linognathus vituli and ... [more ▼]

Field efficacy of a pour-on formulation of moxidectin, a macrocyclic lactone endectocide, was evaluated in cattle naturally infested with Chorioptes bovis, Damalinia bovis, Linognathus vituli and Psoroptes ovis. In trial 1, two experimental groups of cattle naturally infested with P. ovis were formed. Group 1 animals remained as untreated controls whereas Group 2 animals were treated on day 0 with 0.5% moxidectin cattle pour-on at a dose of 0.5 mg kg-1 bw. Efficacy was assessed by (a) taking skin samples from each animal on days -4, 7, 14, 21, 28, 42 and 56 post treatment (PT) and observing the numbers of viable P. ovis mites and (b) clinical examination of animals on days 7, 14, 21, 28, 42 and 56 with the percentage of affected body surface calculated and live body weights recorded for each animal on days 4, 28 and 42. The pour-on formulation of moxidectin yielded excellent efficacy as no live mites were found in treated animals at 14, 21, 28, 42 and 56 days PT, except in one animal from which one adult mite was collected on day 42. Clinical indices showed a regular decrease in the affected body surface area. All untreated animals but one remained positive until day 28 and their clinical condition worsened rapidly. In trial 2, two experimental groups of cattle naturally infested with D. bovis and L. vituli were selected. Group 1 remained as untreated controls whereas Group 2 individuals were treated on day 0 with 0.5% moxidectin cattle pour-on at a dose of 0.5 mg kg-1 bw. Efficacy was assessed by identifying and counting lice on eight 15 cm hair partings at predefined anatomical sites on days 0, 14, 28 and 42. On the basis of animals cured and lice count reduction, efficacies were 100% on day 14 and from then onwards for both species. In trial 3, 24 animals naturally infested with C. bovis were divided into three experimental groups comprising eight (Group I), seven (Group 2) and nine animals (Group 3). Group 1 was the untreated control group whereas Groups 2 and 3 animals were treated on day 0 with 0.5% moxidectin cattle pour-on at a dose of 0.25 mg and 0.5 mg kg-1 bw, respectively. Efficacy was assessed as in trial 1. Skin scrapings were collected on days -3, 7, 14, 28, 42 and 56 PT. A clinical index was calculated for each animal on days 0, 28 and 56 whereas body weights were recorded on days 0 and 56. At 0.25 mg kg-1 bw, the efficacy of moxidectin cattle pour-on against C. bovis was incomplete. In contrast, at a dose of 0.5 mg kg-1 bw, moxidectin cattle pour-on was fully effective and by day 14 PT all animals were negative for C. bovis and remained so until the end of the trial. No side effects were observed during these three trials. These results indicate that at a dose of 0.5 mg kg-1 bw, the pour-on formulation of moxidectin is highly effective against C. bovis, D. bovis, L. vituli and P. ovis. [less ▲]

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See detailEffects on Pcbs on Liver Ultrastructure and Monooxygenase Activities in Japanese Quail
Stouvenakers, Nadine ULg; Hugla, J. L.; Goffinet, Gerhard ULg et al

in Bulletin of Environmental Contamination & Toxicology (1996), 56(5), 839-46

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See detailLes inhibiteurs de l'enzyme de conversion dans l'infarctus du myocarde: qui, quand, comment?
Pierard, Luc ULg

in Revue Médicale de Liège (1996), 51(5), 336-40

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See detailHistamine liberation related to cardiopulmonary bypass in children: Possible relation to transient postoperative arrhythmias
Seghaye, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1996), 111(5), 971-981

Tumor necrosis factor-α production and products of mast cell, basophil, and eosinophil degranulation (prostaglandin D2, histamine, and eosinophil cationic protein) were prospectively studied in 26 ... [more ▼]

Tumor necrosis factor-α production and products of mast cell, basophil, and eosinophil degranulation (prostaglandin D2, histamine, and eosinophil cationic protein) were prospectively studied in 26 children undergoing cardiac operations. The relationship between inflammatory response to cardiopulmonary bypass and transient postoperative arrhythmias was analyzed. Cardiopulmonary bypass was conducted with circulatory arrest and deep hypothermia in 10 patients and with continuous low-flow and moderate hypothermia in 16 patients. Transient postoperative arrhythmias diagnosed on standard or atrial electrocardiograms (or both) were seen in eight of the 26 examined children: accelerated junctional rhythm (n = 3), junctional ectopic tachycardia (n = 3), second-degree atrioventricular block (n = 1), and third- degree atrioventricular block (n = 1). Children with transient postoperative arrhythmias were younger than those without (p < 0.05). Compared with baseline values, there was in all patients a significant release of histamine and eosinophil cationic protein (p < 0.05) related to cardiopulmonary bypass, reaching peak values 4 hours after the operation. In contrast, tumor necrosis factor-α production and prostaglandin D2 release were not significant. This suggests that activated basophils but not mast cells are the major sources of histamine liberated during and after cardiopulmonary bypass. Histamine release but not eosinophil cationic protein release correlated with circulatory arrest and deep hypothermia (p < 0.05), suggesting the participation of physicochemical alterations of circulating basophils leading to histamine liberation. Four hours after the operation, patients with transient postoperative arrhythmias had significantly higher blood concentrations of histamine (p < 0.02) and eosinophil cationic protein (p < 0.05) than did those without transient postoperative arrhythmias. On the first postoperative day, four of the eight patients with transient postoperative arrhythmias had persisting elevated histamine levels, whereas in patients without transient postoperative arrhythmias histamine reached baseline values. The multivariate analysis retained histamine release and eosinophil cationic protein variations related to cardiopulmonary bypass for the emerging model to predict transient postoperative arrhythmias. The results of this study show significant histamine release related to cardiopulmonary bypass. Furthermore, they document a possible relationship between circulating histamine and transient postoperative arrhythmias. The latter may therefore be suspected among the consequences of the inflammatory response to cardiopulmonary bypass. [less ▲]

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See detailEcophysiologie de la production végétale: l'exemple du blé
Bodson, Bernard ULg; Falisse, André

in Probio-Revue (1996), 19(1-2), 85-92

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See detailPharma-clinics. Comment je traite... une acné du visage
Pierard, Gérald ULg

in Revue Médicale de Liège (1996), 51(5), 327-31

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See detailLes assistances circulatoires. Partie II. Complications et résultats
Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1996), 51(5), 359-67

Le placement et le choix d'une assistance uni- ou biventriculaire reposent sur des critères hémodynamiques, cliniques et échographiques et sur certaines données qui imposent d'emblée le choix d'une ... [more ▼]

Le placement et le choix d'une assistance uni- ou biventriculaire reposent sur des critères hémodynamiques, cliniques et échographiques et sur certaines données qui imposent d'emblée le choix d'une assistance biventriculaire, telles les arythmies, l'ischémie du septum interventriculaire et des résistances vasculaires pulmonaires élevées. Le moment idéal pour transplanter un patient sous assistance n'est pas toujours aisé à déterminer. Par le passé, le patient était transplanté dès qu'un donneur était disponible, dans la crainte de la survenue de complications associées au système d'assistance et qui feraient contre-indiquer la transplantation. Actuellement, on sait qu'il est préférable de différer la transplantation jusqu'à la normalisation des fonctions hépatique et rénale, ce qui permet de transplanter le patient dans de meilleures conditions. Les complications principales sous assistance sont: les saignements qui accroissent le risque d'infection en raison des réopérations et des transfusions qu'ils imposent, l'infection, les accidents thromboemboliques et l'insuffisance rénale. Les résultats globaux actuels sont: 1) une survie initiale supérieure à 50% en cas d'assistance circulatoire en pont vers la transplantation, avec une survie actuarielle à 2 ans de l'ordre de 70% après transplantation; 2) une survie globale entre 25 et 30% en cas d'assistance post-cardiotomie. Ces résultats sont loin d'être parfaits, mais ces dispositifs s'adressent à des patients qui, sans assistance circulatoire, ont une espérance de vie nulle à très brève échéance. Néanmoins, des progrès restent à faire dans le domaine de la tolérance des matériaux utilisés ainsi que dans la sélection des patients. Dans le futur, des systèmes totalement implantables constitueront peut-être une alternative valable à la transplantation. [less ▲]

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See detailAuto-formation et hypermédias : qu'est-ce qu'un bon apprenant ?
Denis, Brigitte ULg; Leclercq, Dieudonné ULg

in Les Cahiers d'Etudes du CUEEP (1996), (32-33), 155-161

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See detailDifunctional initiators based on 1,3-diisopropenylbenzene. 3. Synthesis of a pure dilithium adduct and its use as difunctional anionic polymerization initiator
Yu, Y. S.; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecules (1996), 29(8), 2738-2745

The addition reaction of tert-butyllithium (t-BuLi) to 1,3-diisopropenylbenzene (1,3-DIB) has been studied. Under optimized conditions, i.e., reaction in cyclohexane at −20 °C and dropwise addition of 1,3 ... [more ▼]

The addition reaction of tert-butyllithium (t-BuLi) to 1,3-diisopropenylbenzene (1,3-DIB) has been studied. Under optimized conditions, i.e., reaction in cyclohexane at −20 °C and dropwise addition of 1,3-DIB to a 1:1 t-BuLi−triethylamine (Et3N) complex followed by a 1 h postreaction period, a pure diadduct is formed without concomitant oligomerization of 1,3-DIB. The behavior of this diadduct has been investigated, in apolar and polar solvents; triblock copolymers have been prepared and found to have interesting mechanical properties. [less ▲]

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See detailGeneral Catalogue of Ap and Am stars (Renson+ 2009)
Renson, Pierre ULg; Gerbaldi, M.; Catalano, F. A.

in VizieR Online Data Catalog (1996), 3162

A catalogue of 8205 known or suspected Ap, HgMn and Am stars is presented. This is a major update of the catalogue of Ap and Am stars (Renson et al., 1991, III/162A). It includes revised identifications ... [more ▼]

A catalogue of 8205 known or suspected Ap, HgMn and Am stars is presented. This is a major update of the catalogue of Ap and Am stars (Renson et al., 1991, III/162A). It includes revised identifications, additional stars and revised information. Bertaud and GC identifications were suppressed. HIP and TYC identifications were added. The GC number can be found in notes N for stars without HIP number and for double stars when the components have different numbers (the GC of the other component is then given in note D). (2 data files). [less ▲]

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See detailOligomerization and copolymerization of γ-butyrolactone - a monomer known as unable to homopolymerize, 1. Copolymerization with epsilon-caprolactone
Duda, Andrzej; Penczek, Stanislaw; Dubois, Philippe ULg et al

in Macromolecular Chemistry and Physics (1996), 197(4), 1273-1283

Copolymerization of γ-butyrolactone (γBL) with ε-caprolactone (εCL) initiated with aluminium isopropoxide trimer ([Al(OiPr)3 ]3, (A3)) is described. Copolymers with molecular weights ( ) up to 3 ; 104 and ... [more ▼]

Copolymerization of γ-butyrolactone (γBL) with ε-caprolactone (εCL) initiated with aluminium isopropoxide trimer ([Al(OiPr)3 ]3, (A3)) is described. Copolymers with molecular weights ( ) up to 3 ; 104 and containing up to 43 mol-% repeating units derived from γBL are prepared. Their molecular weight is controlled by the concentrations of the consumed comonomers and the starting concentration of initiator { = (86.09 ; [γBL]c + 114.14 ; [εCL]0)/3[Al(OiPr)3] + 60.10}. 13C NMR and DSC data are indicative of a pseudoperiodic or random copolymer structure. [less ▲]

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See detailEffect of Propofol on in Vitro Lipid Peroxidation Induced by Different Free Radical Generating Systems: A Comparison with Vitamin E
Hans, Pol ULg; Deby, Christiane ULg; Deby-Dupont, G. et al

in Journal of Neurosurgical Anesthesiology (1996), 8(2), 154-8

Propofol has been reported to have antioxidant properties and to inhibit lipid peroxidation. In this study, we examined the ability of propofol to inhibit lipid peroxidation induced by three free radical ... [more ▼]

Propofol has been reported to have antioxidant properties and to inhibit lipid peroxidation. In this study, we examined the ability of propofol to inhibit lipid peroxidation induced by three free radical systems (hydroxyl, ferryl, and oxo-ferryl radicals), and we compared the effect of propofol with that of vitamin E, an endogenous antioxidant. Lipid peroxidation was induced by exposing a linoleic acid emulsion to either water gamma radiation, a ferrous iron-ascorbate solution, or human hemoglobin, generating the hydroxyl, ferryl, and oxo-ferryl radicals, respectively. Each experiment was performed in triplicate with and without propofol or vitamin E at concentrations between 10(-5) and 10(-4) M. Lipid peroxidation was quantified by gas chromatography measurement of the pentane released (nmoles) from lipid decomposition. In each condition, a significant dose-response relationship was found between the release of pentane and the concentration of either propofol or vitamin E. The antioxidant activities of both agents were similar but significantly higher against the hydroxyl than the ferryl and oxo-ferryl radicals. The study suggests that propofol could be beneficial as an anesthetic or sedative drug in patients presenting pathologies associated with free radical reactions. [less ▲]

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See detailPolylactide Macroporous Biodegradable Implants for Cell Transplantation. Ii. Preparation of Polylactide Foams by Liquid-Liquid Phase Separation
Schugens, C.; Maquet, Véronique; Grandfils, Christian ULg et al

in Journal of Biomedical Materials Research (1996), 30(4), 449-61

Potential of thermally induced phase separation as a porogen technique has been studied in an effort to produce a surgical implant suitable for cell transplantation. Emphasis has been placed on the liquid ... [more ▼]

Potential of thermally induced phase separation as a porogen technique has been studied in an effort to produce a surgical implant suitable for cell transplantation. Emphasis has been placed on the liquid-liquid phase separation of solutions of amorphous poly DL-lactide and semicrystalline poly L-lactide in an 87/13 dioxane/water mixture. The related temperature/composition phase diagrams have been set up by turbidimetry, and the possible occurrence of a gel has been discussed. Freeze-drying of some phase-separated polylactide solutions can produce flexible and tough foams with an isotropic morphology. Interconnected pores of 1-10 microns in diameter are expected to result from the spinodal decomposition of the polylactide solutions with formation of co-continuous phases. Thermodynamics of the polymer/solvent pair has a decisive effect on the final macroporous foams, as shown by the dependence of their porosity, density, porous morphology, and mechanical behavior on molecular weight and crystallinity of polylactide and concentration of the original solutions. On the basis of the foam characteristics, potential of the liquid-liquid phase separation (spinodal decomposition) has been compared with the solid/liquid phase separation (solvent crystallization) as a porogen technique. [less ▲]

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See detailSpeciations and extinctions in a self-organizing critical model of tree-like evolution
Kramer, M.; Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Journal de Physique I (1996), 6(4), 599-606

We study analytically a simple model of a self-organized critical evolution. The model considers both extinction and speciation events leading to the growth of phylogenetic-like trees. Through a mean ... [more ▼]

We study analytically a simple model of a self-organized critical evolution. The model considers both extinction and speciation events leading to the growth of phylogenetic-like trees. Through a mean-field like theory, we study the evolution of the local configurations for the tree leaves. The fitness threshold, below which life activity takes place through avalanches of all sizes is calculated. The transition between speciating (evolving) and dead trees is obtained and is in agreement with numerical simulations. Moreover, this theoretical work suggests that the structure of the tree is strongly dependent on the extinction strength. [less ▲]

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See detailBrain activation induced by estimation of duration : A PET study
Maquet, Pierre ULg; Lejeune, Helga ULg; Pouthas, V. et al

in Neuroimage (1996), 3(2), 119-126

Duration information about a visual stimulus requires processing as do other visual features such as size or intensity. Using positron emission tomography, iterative (H2O)-O-15 infusions, and statistical ... [more ▼]

Duration information about a visual stimulus requires processing as do other visual features such as size or intensity. Using positron emission tomography, iterative (H2O)-O-15 infusions, and statistical parametric mapping, we investigated the neural correlates of time processing. Nine normal subjects underwent six serial rCBF. Three tasks were studied: (a) Atemporal generalization task (D task) in which the subjects had to judge (by pressing one of two keys) whether the duration of the illumination of a green LED was equal to or different from that of a previously presented standard; (b) An intensity generalization task. (I task) in which the judgment concerned the intensity of the LED; and (c) A control task (C task) in which the subjects had to press one of the two keys at random in response to LED illumination. A significant increase in rCBF during the D task, compared to that during the C task, was observed in right prefontal cortex, right inferior parietal lobule, anterior cingulate cortex, vermis, and a region corresponding to the left fusiform gyrus. A significant increase in rCBF during the I task, compared to that during the C task, was observed in right prefontal cortex, right inferior parietal lobule, right extrastriate cortex, anterior cingulate cortex, left inferior parietal lobule, vermis, and two symmetrical regions corresponding to the fusiform gyri. No significant activation was observed in the D task when compared to that in the I task. We propose that these cortical maps are best explained by the recruitment of visual attention and memory structures, which play a major role in prospective time judgements as indicated by behavioral studies. The data also suggest that the temporal dimension of a visual stimulus is processed in attributes. the same areas as other visual attributes. [less ▲]

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See detailAutologous Blood Donation Plus Epoetin Alfa in Nonanemic Orthopedic Surgery Patients
Baudoux, Etienne ULg

in Seminars in Hematology (1996), 33(2 Suppl 2), 31-233

Intravenous (i.v.) administration of epoetin alfa facilitates the collection of autologous blood (AB) prior to elective orthopedic surgery. However, the optimum dose and dosage regimen remains to be ... [more ▼]

Intravenous (i.v.) administration of epoetin alfa facilitates the collection of autologous blood (AB) prior to elective orthopedic surgery. However, the optimum dose and dosage regimen remains to be defined. The aim of this multicenter, randomized, placebo-controlled study was to determine the optimum i.v. dose of epoetin alfa (300 IU/kg or 600 IU/kg) that would allow nonanemic patients to donate > or = 4 units of AB within 14 to 21 days of elective orthopedic surgery. All patients (n = 103) received oral iron supplementation and were treated with epoetin alfa or placebo three times during 1 week, within 3 weeks of surgery. Eighty patients were evaluable in the efficacy analysis. Compared with placebo, significantly more evaluable patients treated with epoetin alfa were able to donate > or = 4 AB units. Furthermore, epoetin alfa dose-dependently increased the preoperative reticulocyte count and attenuated the decrease in hematocrit associated with AB predonation. There was no significant difference with respect to allogeneic blood exposure between the epoetin alfa and placebo treatment groups. In addition, the 600 IU/kg dose was not significantly more effective than the 300 IU/kg dose for most efficacy parameters assessed. Several patients became iron-deficient, suggesting that oral supplementation is not an adequate source of iron in these patients. Epoetin alfa 300 IU/kg therefore appears to be the optimum i.v. dose for facilitating the collection of > or = 4 units of AB within 14 to 21 days of elective orthopedic surgery. [less ▲]

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See detailComparison of modeled and empirical approaches for retrieving columnar water vapor from solar transmittance measurements in the 0.94 micrometer region
Schmid, B; Thome, K.J.; Demoulin, Philippe ULg et al

in Journal of Geophysical Research (1996), 101

Four atmospheric transmittance models, LOWTRAN 7, MODTRAN 3, FASCOD3P, and the Thomason model, are investigated to quantify the relationship between water vapor transmittance as function of water vapor ... [more ▼]

Four atmospheric transmittance models, LOWTRAN 7, MODTRAN 3, FASCOD3P, and the Thomason model, are investigated to quantify the relationship between water vapor transmittance as function of water vapor amount, Tw (U), for an instrument specific band pass in the 0.94-um region. In a second step an empirical Tw (U) function is established using long term measurements with our high-precision Sun photometer (SPM) in Bern, Switzerland along with 1300 simultaneous and collocated water vapor retrievals performed with a dual-channel microwave radiometer (MWR). In order to avoid a possible bias in the empirical Tw(U) function, the MWR data set is prescreened by comparing retrievals coincident with radiosonde ascents. Over a 2 1/2-year period of common observations, radiosondes and PM agreed to within 0.19 cm (13%) of columnar water vapor (CWV) using the empirical Tw (U) relationship. Completely independent comparisons with an additional MWR and two Fourier transform spectrometers yielded agreement within 13% and 9%, respectively. Comparing empirical and modeled results, we found that with respect to the experimental data, LOWTRAN 7, MODTRAN 3, and FASCOD3P reported higher water vapor transmittances over almost the entire range of realistic absorber amounts. By relating these differences to differences in retrieved CWV for the case of two standard atmospheres, we found that using Tw (U) predicted by LOWTRAN 7, MODTRAN 3, and FASCOD3P leads to an overestimate of CWV by about 18-30%, 7-20%, and 2-18%, respectively. The Thomason model yields good agreement with respect to the experimental data up to medium absorber amounts, whereas at slant path amounts larger than 10 cm, errors up to 60% in retrieved CWV occurred. We also show in this work that a misinterpretation of the LOWTRAN 7 water vapor output counterbalances incorrectly predicted Tw, leading to results that agree well with experimental ones [less ▲]

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See detailComment j'explore ... une suspicion de cancer broncho-pulmonaire par tomographie a émission de positrons
Bury, Thierry ULg; Paulus, Patrick; Weber, Thierry et al

in Revue Médicale de Liège (1996), 51(4), 317-9

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See detailLaparoscopic-Assisted Colectomy in Heart Transplant Recipients
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Chiche, Jean-Daniel et al

in Clinical Transplantation (1996), 10(2), 191-4

Reports of laparoscopy in heart graft recipients are scarce and, to our knowledge, laparoscopic colectomy has not yet been reported in heart transplant patients. The magnitude and the tolerance of the ... [more ▼]

Reports of laparoscopy in heart graft recipients are scarce and, to our knowledge, laparoscopic colectomy has not yet been reported in heart transplant patients. The magnitude and the tolerance of the hemodynamic changes induced by pneumoperitoneum are unknown in heart graft recipients, who have a denervated heart and are "preload-dependent". The authors report the clinical courses of 2 heart graft recipients who developed acute diverticulitis without perforation or peritonitis and who underwent laparoscopic-assisted colectomy without complications. [less ▲]

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See detailIntraoperative Localisation of the Primary Motor Cortex Using Single Electrical Stimuli
Maertens De Noordhout, Alain ULg; Born, J. D.; Hans, Pol ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (1996), 60(4), 442-4

A new method of intraoperative localisation of the primary motor cortex is described, based on the application of single anodal electric pulses to the brain surface. Patients were anaesthetised with ... [more ▼]

A new method of intraoperative localisation of the primary motor cortex is described, based on the application of single anodal electric pulses to the brain surface. Patients were anaesthetised with propofol infusion, and neuromuscular blockade was temporarily alleviated to allow recording of surface EMG responses (CMAPs) to the stimuli. Primary motor areas could be localised in 18/19 patients studied. In the other patient, no responses were elicited, as the operative field was posterior to the motor cortex. When compared with MEPs elicited in awake patients by magnetic stimuli, responses to intraoperative anodal stimulation were of small amplitude (usually less than 10% of MEPs) and their latency was some 1 to 2 ms longer. One month after the operation, only 1/19 patients was left with a slight muscle weakness, although seven showed preoperative motor deficit. The procedure proved easy and fast, needing no preliminary surgery or time consuming preparation. It did not induce any detectable side effects. [less ▲]

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See detailLes assistances circulatoires. Partie I. Indications et description des systèmes
Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1996), 51(4), 295-306

Dans l'optique d'une assistance circulatoire, les défaillances cardiaques sont classables en trois grandes catégories: 1) le choc cardiogénique inaugural consécutif à une myocardite ou à un infarctus du ... [more ▼]

Dans l'optique d'une assistance circulatoire, les défaillances cardiaques sont classables en trois grandes catégories: 1) le choc cardiogénique inaugural consécutif à une myocardite ou à un infarctus du myocarde; 2) la défaillance post-chirurgicale ou post-cardiotomie; 3) la détérioration hémodynamique rapide chez un patient préalablement inscrit dans un programme de transplantation. Dans ces circonstances, une assistance circulatoire s'impose lorsque les critères de Norman sont présents (index cardiaque inférieur à 1,8 l/min/m2; pression artérielle systolique < 90 mmHg; pressions d'oreillettes gauche et/ou droite > à 20 mmHg; débit urinaire inférieur à 20 ml/heure; résistances vasculaires systémiques > 250 dynes/cm2; acidose métabolique), et ce malgré un remplissage vasculaire correct, un support inotrope maximal et une contrepulsation infra-aortique. En assurant une perfusion tissulaire adéquate et la mise au repos du myocarde, l'assistance permet alors soit une récupération myocardique, soit d'attendre une transplantation dans de meilleures conditions (pont vers la transplantation ou bridge to transplant). Pour répondre aux objectifs d'une assistance circulatoire, plusieurs systèmes sont disponibles. Ils différent par leur mode d'insertion, le type d'assistance qu'ils fournissent (partielle ou totale, univentriculaire gauche ou droite, biventriculaire), le type de débit assuré (continu ou pulsatile), le degré d'anticoagulation requis, la durée théorique maximale d'assistance, leurs positions (interne, externe, hétérotopique ou orthotopique), leurs modes de connexion aux cavités cardiaques. Le choix est guidé par l'origine du choc, par les circonstances géographiques lors de sa survenue (salle de cathétérisme ou salle d'opération) et, bien évidemment, par la disponibilité locale des systèmes d'assistance, qui sont onéreux. [less ▲]

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See detailUse of two pregnancy-associated glycoprotein RIA's for pregnancy diagnosis in white-tailed deer
Osborn, D. A.; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Journal of Wildlife Management (1996), 60(2), 388-393

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See detailEffect of sodium nitroprusside on complement activation induced by cardiopulmonary bypass: A clinical and experimental study
Seghaye, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1996), 111(4), 882-892

Complement activation and leukocyte stimulation were prospectively studied during and after cardiopulmonary bypass in 16 children receiving sodium nitroprusside-a nitrovasodilator releasing nitric oxide ... [more ▼]

Complement activation and leukocyte stimulation were prospectively studied during and after cardiopulmonary bypass in 16 children receiving sodium nitroprusside-a nitrovasodilator releasing nitric oxide-for vasodilation during the cooling and rewarming periods of extracorporeal circulation. Results were compared with those in 29 patients who were not treated with sodium nitroprusside during the operation. Patients treated with sodium nitroprusside had significantly less C3 conversion during cardiopulmonary bypass as measured by the ratio C3d/C3 (p < 0.05) and significantly less C5a liberation immediately after cardiopulmonary bypass (p < 0.005) than patients not treated with sodium nitroprusside. C4 was not overtly consumed in our series. Leukocyte count during the rewarming period of cardiopulmonary bypass, but not leukocyte elastase release during cardiopulmonary bypass, was significantly reduced in patients treated with sodium nitroprusside (p < 0.05). In vitro experiments were conducted to analyze the effect of sodium nitroprusside on complement hemolytic activity initiated by the classic and the alternate pathways and on zymosan-induced C3 conversion by the activation of the alternate pathway. The in vitro experiments clearly demonstrate inhibition of complement hemolytic activity by sodium nitroprusside in the sera tested. The 50% inhibitory concentration of sodium nitroprusside on the available complement hemolytic activity was less through the alternate pathway than through the classic one (4.2 ± 0.8 mmol/L and 14.0 ± 2.88 mmol/L, respectively). The decrease of complement hemolytic activity measured was dose-dependent and was enhanced by the sodium nitroprusside preincubation of the sera tested. This effect was related to the duration of preincubation. Sodium nitroprusside photodegradation (enhancing nitric oxide release) increased the anticomplementary effect of the drug, reducing the 50% inhibitory concentration on complement hemolytic activity to 0.24 to 0.02 mmol/L for the alternate pathway and 2.74 o 0.3 mmol/L for the classic pathway. The zymosan-induced C3 conversion was inhibited by sodium nitroprusside. Nitroglycerin and isosorbide dinitrate (other nitric oxide donors) had in vitro effects on complement hemolytic activity similar to those of nonphotodegraded sodium nitroprusside at similar concentrations (1 mmol/L). Our results suggest that sodium nitroprusside, both in vitro and in vivo, has an inhibiting effect on complement activation initiated by both classic and alternate pathways and that this effect is mediated by nitric oxide release from sodium nitroprusside. This is the first report on the anticomplementary effect of sodium nitroprusside by nitric oxide release. [less ▲]

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See detailInfluence of low-dose aprotinin on the inflammatory reaction due to cardiopulmonary bypass in children
Seghaye, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Annals of Thoracic Surgery (1996), 61(4), 1205-1211

Background. The serine protease inhibitor aprotinin inhibits trypsin, kallikrein, and plasmin and enhances the complement hemolytic activity of the first complement component C1. We tested whether low ... [more ▼]

Background. The serine protease inhibitor aprotinin inhibits trypsin, kallikrein, and plasmin and enhances the complement hemolytic activity of the first complement component C1. We tested whether low-dose aprotinin influences the inflammatory reaction related to cardiopulmonary bypass. Methods. In an open, randomized study, 25 children undergoing cardiac operations were investigated prospectively. The treated group comprised 11 patients receiving low-dose aprotinin (20,000 kIU/kg [2.8 mg/kg]), and the control group included 14 patients. Complement activation, cytokine production, and leukocyte stimulation were analyzed before, during, and after cardiopulmonary bypass. Results. In all children, significant C3 conversion and C5a generation, interleukin-6 synthesis, and myeloperoxidase, eosinophil cationic protein, and histamine liberation occurred in relation to cardiopulmonary bypass. This was not influenced by aprotinin treatment. In contrast, neutrophil kinetic studies at the end of cardiopulmonary bypass showed a significantly lower increase in the aprotinin as compared with the control group. Conclusions. Our results suggest that low-dose aprotinin has little influence on the inflammatory reaction induced by cardiopulmonary bypass. Aprotinin affects neutrophil mobilization but not white blood cell degranulation related to cardiopulmonary bypass, and has no influence on complement activation and interleukin-6 synthesis. [less ▲]

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See detailMacromolecular engineering of polylactones and polylactides. 19. Kinetics of ring-opening polymerization of epsilon-caprolactone initiated with functional aluminum alkoxides
Dubois, Philippe ULg; Ropson, Nathalie; Jérôme, Robert ULg et al

in Macromolecules (1996), 29(6), 1965-1975

End-functional aliphatic polyesters have been synthesized by ring-opening polymerization (ROP) of epsilon-caprolactone (epsilon-CL) and lactides (LA). Polymerization initiated with any of the functional ... [more ▼]

End-functional aliphatic polyesters have been synthesized by ring-opening polymerization (ROP) of epsilon-caprolactone (epsilon-CL) and lactides (LA). Polymerization initiated with any of the functional aluminum alkoxides of the general structure Et(3-p)Al(OCH(2)X)(p), where p = 1 and 3, obeys a living ''coordination-insertion'' mechanism, under suitable conditions (temperature, concentration, and solvent), with the formation of alpha-functional chains of a predictable molecular weight. A kinetic study has emphasized the importance of the cyclic monomer (epsilon-CL or LA) and the key role of the initiator structure: the number of functional alkoxides per aluminum and the nature of the functional group (X = CH2Br, (CH2)(2)CH=CH2, (CH2)(2)NEt(2)). Activation enthalpy and entropy have been calculated for the epsilon-CL polymerization initiated by several aluminum alkoxides at various temperatures. The effects of solvent (toluene or tetrahydrofuran) and purification of the aluminum monoalkoxides by distillation under reduced pressure have also been considered. [less ▲]

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See detailTerritorial and non-territorial spawning behaviour in the bream
Poncin, Pascal ULg; Philippart, Jean-Claude ULg; Ruwet, J. C.

in Journal of Fish Biology (1996), 49(4), 622-626

The spawning behaviour of bream Abramis brama was studied in 1993, in a harbour on the River Meuse, Belgium. Fish spaced from 22 to 27 April and from 11 to 14 May, when the water temperature rose to 14.5 ... [more ▼]

The spawning behaviour of bream Abramis brama was studied in 1993, in a harbour on the River Meuse, Belgium. Fish spaced from 22 to 27 April and from 11 to 14 May, when the water temperature rose to 14.5 degrees C. The reproductive behaviour of the bream was studied within a 15 m long part of the harbour using a video camera. Territorial males with tubercles (33-43 cm total length; > 5 years old) defended bank areas of diameter 80-150 cm which included spawning substratum, i.e. roots of alder and willow trees and aquatic plants. Water depth ranged from 25 to 50 cm. Non-territorial males without tubercles (24-33 cm; 3-4 years old), remained 2-4 m away from the bank. Aggressive behaviour between males was frequent and, occasionally, males with tubercles were unable to defend a territory. Mature females (25-43 cm; > 3 years old), coming from the deeper water of the surrounding area, were followed by non-territorial males before spawning in territories near the bank. (C) 1996 The Fisheries Society of the British Isles [less ▲]

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See detailImproved Four-Color Flow Cytometry Method Using Fluo-3 and Triple Immunofluorescence for Analysis of Intracellular Calcium Ion ([Ca2+]I) Fluxes among Mouse Lymph Node B- and T-Lymphocyte Subsets
Greimers, Roland ULg; Trebak, M.; Moutschen, Michel ULg et al

in Cytometry (1996), 23(3), 205-17

A visible-light, dual-laser, flow cytometric method was developed for the simultaneous analysis of intracellular ionized calcium concentration ([Ca2+]i) and three cell-surface markers (CD4, CD8, and Thy-1 ... [more ▼]

A visible-light, dual-laser, flow cytometric method was developed for the simultaneous analysis of intracellular ionized calcium concentration ([Ca2+]i) and three cell-surface markers (CD4, CD8, and Thy-1.2 antigens) by using the calcium probe fluo-3 and using R-phycoerythrin (PE), peridinin chlorophyll-alpha protein (PerCP), and allophycocyanin (APC) conjugated monoclonal antibodies (MoAbs). This improved method was used in the analysis of [Ca2+]i mobilization upon in vitro stimulation with mitogenic lectins [phytohaemagglutinin (PHA) or concanavalin A (ConA)], anti-CD3 MoAbs, or A23187 calcium ionophore in the heterogeneous lymph node cell populations from healthy C57BL/Ka mice. The present results show that the calcium responses were heterogeneous and dependent on the cellular immunophenotype, not only on lectins or anti-CD3 MoAbs stimulation, but also on the receptor-independent A23187 ionophore stimulation. An in situ fluo-3 calibration method (using A23187 and metabolic poisons in Ca2+ /EGTA buffers with known free calcium concentrations) indicated a resting [Ca2+]i in lymphocytes of 103 +/- 23 nM (mean +/- S.D.) but with significant differences between the [Ca2+]i in B cells and in all of the T-cell subsets (CD4+Thy-1+, CD4+Thy-1-, and CD8+T cells). Both the B cells and the T-cell subsets showed an increase of fluo-3 fluorescence upon in vitro stimulation with ConA or PHA, but the calcium mobilization following lectin stimulation was time delayed in all T-cell subsets. Only the T cells, including the CD4+Thy-1- subset, responded to anti-CD3 MoAbs. The percentage of responding cells upon stimulation with ConA was higher in T cells than in B cells. By contrast, PHA gave a higher response in B cells. After stimulation with different mitogens, [Ca2+]i increased in both CD4+ and CD8+ T-cell subsets. However, the percentage of responding cells was far higher in the CD4+Thy-1+ subset than in the CD4+Thy-1- or the CD8+T-cell subsets. The stimulation with A23187 ionophore induced a higher calcium response in B cells than in T cells. Interestingly, it also induced greater Ca2+ mobilization in CD4+ than in CD8+T cells. These results demonstrate the potential use of fluo-3 simultaneously with three fluorescein (FITC)-compatible fluorochromes. This technique may be useful for investigating the role of the CD4+Thy-1-T cells, a rare subset that is abnormally expanded in a murine acquired immunodeficiency syndrome (murine AIDS). [less ▲]

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See detailIdentification and overexpression in Escherichia coli of a Mycobacterium leprae gene, pon1, encoding a high-molecular-mass class A penicillin-binding protein, PBP1
Basu, Joyoti; Mahapatra, Sebabrata; Kundu, Manikuntala et al

in Journal of Bacteriology (1996), 178(6), 1707-1711

Cosmid B577, a member of the collection of ordered clones corresponding to the genome of Mycobacterium leprae, contains a gene, provisionally called pon1, that encodes an 821-amino-acid-residue high ... [more ▼]

Cosmid B577, a member of the collection of ordered clones corresponding to the genome of Mycobacterium leprae, contains a gene, provisionally called pon1, that encodes an 821-amino-acid-residue high-molecular-mass class A penicillin-binding protein, provisionally called PBP1. With similar amino acid sequences and modular designs, M. leprae PBP1 is related to Escherichia coli PBP1a and PBP1b, bienzymatic proteins with transglycosylase and transpeptidase activities. When produced in E. coli, His tag-labelled derivatives of M. leprae PBP1 adopt the correct membrane topology, with the bulk of the polypeptide chain on the surface of the plasma membrane. They defy attempts at solubilization with all the detergents tested except cetyltrimethylammonium bromide. The solubilized PBP1 derivatives can be purified by affinity chromatography on Ni2+-nitrilotriacetic acid agarose. They have low affinities for the usual penicillins and cephalosporins. [less ▲]

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See detailDistribution of varicella-zoster virus and herpes simplex virus in disseminated fatal infections
Nikkels, Arjen ULg; Delvenne, Philippe ULg; Sadzot-Delvaux, Catherine ULg et al

in Journal of Clinical Pathology (1996), 49(3), 243-248

AIMS: To study the cutaneous and visceral distribution of herpes simplex virus (HSV) and varicella zoster virus (VZV) in fatal infections. METHODS: Standard histology, immunohistochemistry (monoclonal ... [more ▼]

AIMS: To study the cutaneous and visceral distribution of herpes simplex virus (HSV) and varicella zoster virus (VZV) in fatal infections. METHODS: Standard histology, immunohistochemistry (monoclonal antibodies VL8 and VL2 and polyclonal antibody IE63 directed against VZV; monoclonal antibodies IBD4 and HH2 and polyclonal antibodies directed against HSVI and HSVII) and in situ hybridisation (anti-HSV and anti-VZV probes) were applied to formalin fixed, paraffin wax sections. RESULTS: On histological examination, Herpesviridae infection was evident in various organs including the lungs, liver and skin. In addition, immunohistochemistry and in situ hybridisation revealed the presence of HSV and VZV antigens and nucleic acids in several cell types and tissues showing no cytopathological alterations suggestive of Herpesviridae infection. The organs with histological evidence of infection also contained VZV or HSV antigens and their genes. CONCLUSIONS: These findings suggest that organ failure in disseminated VZV and HSV infections is primarily caused by HSV or VZV induced cell damage and lysis. They also indicate that immunohistochemistry and in situ hybridisation can provide an accurate, type-specific diagnosis on formalin fixed, paraffin wax embedded tissue even when classic histological and cytological characteristics are lacking. [less ▲]

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See detailAnthropologie de l'adolescence
Stassart, Martine ULg

in Cahiers du CEP. Centre d'Etudes Pathoanalytiques (1996), 7(1), 13-37

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See detailCritères de l'IHMF pour le traitement des infections à VZV
Rentier, Bernard ULg

in Virologics (1996), (Mars), 4-5

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See detailInterleukin-10 release related to cardiopulmonary bypass in infants undergoing cardiac operations
Seghaye, Marie-Christine ULg; Duchateau, J.; Bruniaux, J. et al

in Journal of Thoracic and Cardiovascular Surgery (1996), 111(3), 545-553

To evaluate cytokine balance related to cardiopulmonary bypass, we prospectively investigated 11 infants undergoing cardiac operations for congenital heart disease. Proinflammatory cytokines (tumor ... [more ▼]

To evaluate cytokine balance related to cardiopulmonary bypass, we prospectively investigated 11 infants undergoing cardiac operations for congenital heart disease. Proinflammatory cytokines (tumor necrosis factor- α and interleukin-8) and the antiinflammatory cytokine interleukin-10 were measured at multiple time points before, during, and after bypass. Tumor necrosis factor-α and interleukin-8 values were within normal range before the operation. These values increased significantly during bypass, reaching their peaks after protamine administration (tumor necrosis factor-α, 133.6 ± 124.9 pg/ml; mean ± standard deviation; p < 0.005) and 2 hours after termination of the procedure (interleukin-8, 92.1 ± 44.1 pg/ml; p < 0.01). Tumor necrosis factor-α and interleukin-8 equaled normal prebypass values from the first postoperative day on. Interleukin-10 levels were within normal range before the operation and were already significantly increased 10 minutes after initiation of bypass (interleukin-10, 39.4 ± 34.3 pg/ml; p < 0.05). These levels remained elevated throughout the procedure but returned to normal after protamine administration. A second significant release of interleukin-10 occurred from the early postoperative period on, reaching its peak 24 hours after termination of cardiopulmonary bypass (interleukin-10, 351.6 ± 304.0 pg/ml; p < 0.01). Interleukin-10 values were normal on the second postoperative day in all patients. Interleukin-10 kinetics showed an inverse pattern compared with tumor necrosis factor-α and interleukin-8. This difference suggests an interplay between proinflammatory and antiinflammatory cytokines released during and after cardiopulmonary bypass. Interleukin-10 levels measured 4 and 24 hours after bypass strongly correlated with the degree of hypothermia during bypass (Spearman's correlation coefficient, -0.77 [p < 0.01] and -0.89 [p < 0.0005], respectively); these levels did not correlate with duration of bypass and aortic crossclamping, however. This result suggests that besides immunologically mediated production of interleukin-10, hypothermia itself could modulate interleukin-10 production. In conclusion, this study demonstrates interleukin-10 production, in addition to interleukin-8 and tumor necrosis factor-α synthesis, in response to cardiopulmonary bypass in infants. Interleukin-10 could play a protective role by down-regulating proinflammatory cytokine release during and after cardiopulmonary bypass. [less ▲]

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See detailEffects of Ipriflavone and Its Metabolites on Human Articular Chondrocytes Cultivated in Clusters
Bassleer, C. T.; Franchimont, P. P.; Henrotin, Y. E. et al

in Osteoarthritis and Cartilage (1996), 4

Ipriflavone (IP) is an isoflavone derivative that was suggested to have bone-sparing effects in post-menopausal and senile osteoporosis. A moderate stimulatory effect of IP and its metabolites on ... [more ▼]

Ipriflavone (IP) is an isoflavone derivative that was suggested to have bone-sparing effects in post-menopausal and senile osteoporosis. A moderate stimulatory effect of IP and its metabolites on proliferation of osteoblastic cells was reported in rat osteoblastic osteosarcoma cell line. We investigated the effects of different concentrations (0, 1, 10 and 100 micrograms/ml) of IP and its metabolites (MET I, II, III and V) on the incorporation of [3H] thymidine and production of proteoglycans (PG) and type II collagen (COL II) by human articular chondrocytes during a 12-day period, in a three-dimensional chondrocyte culture model. [3H]thymidine uptake was measured in chondrocyte clusters, and specific PG and COL II radioimmunoassays were performed every 4 days on the culture medium and cell clusters. Incubation with IP or its metabolites did not affect [3H]thymidine uptake regardless of the dose. PG released into the culture medium and PG cluster content rose significantly (P < 0.025) in presence of IP (1, 10 and 100 micrograms/ml). MET I increased PG release in culture medium (10 and 100 micrograms/ml) and PG cluster content (100 micrograms/ml). MET II has no effect on PG production. MET III increased PG in culture medium (100 microgram/ml) but did not influence PG cluster content while MET V (100 micrograms/ml) increased both PG release in culture medium and PG cluster content. COL II release in culture medium and COL II cluster content were significantly (P < 0.025) increased in presence of IP (10 and 100 micrograms/ml), MET III (1, 10 and 100 micrograms/ml) or MET V (100 micrograms/ml). MET I and II did not significantly affect COL II production. [less ▲]

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See detailGrowing into adult age : Cross-cultural point of view about adolescence
Stassart, Martine ULg

in Cahiers du CEP. (1996), 7(1), 13-38

There is no need to question the universality of the Oedipus complex: there is there always will be a paternal and a maternal imago to fix the primitive libido and the agressive drives through desire ... [more ▼]

There is no need to question the universality of the Oedipus complex: there is there always will be a paternal and a maternal imago to fix the primitive libido and the agressive drives through desire, jealousy and competition. On the other hand, what makes the major difference between the archaic mind and our modern western ideology is their cultural management of the Oedipus complex? Archaic societies use of rites of passage to prevent the return of Oedipus in adolescence whiile our culture gives free rein to the return of the repressed and does not fix any limit for adolescence to end. Each individual is then solitarily in charge of the stabilization of his adult identity. [less ▲]

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See detailRétinoïdes et leucémie aigue promyelocytaire. Une révolution thérapeutique
Hermanne, Jean-Philippe; Tassin, Françoise ULg; Bours, Vincent ULg et al

in Revue Médicale de Liège (1996), 51(3), 217-23

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See detailUtilisation des microsphères biodégradables en thérapie anti-cancéreuse expérimentale. Application chronopharmacologique
Milis, G.; Grandfils, Christian ULg; Flandroy, P. et al

in Pathologie Biologie (1996), 44(3), 208-11

We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those ... [more ▼]

We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those cisplatin loaded microspheres, some concentration peaks at the best tolerance time. The cancer is than more hit, by the high local anticancer drug concentration, and doses chronomodulations preserve the patient by following his tolerance. The experimentation on cancerous mice show that this technique could lead to great survival increases. Such a protocol might usefuly improve the anticancer therapy. [less ▲]

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See detailEvaluation of the Solitary Pulmonary Nodule by Positron Emission Tomography Imaging
BURY, Thierry ULg; Dowlati, A.; Paulus, P. et al

in European Respiratory Journal (1996), 9(3), 410-4

Current noninvasive imaging methods are not sufficiently reliable for accurate detection of malignancy in most solitary pulmonary nodules (SPNs). Positron emission tomography (PET) using 18 ... [more ▼]

Current noninvasive imaging methods are not sufficiently reliable for accurate detection of malignancy in most solitary pulmonary nodules (SPNs). Positron emission tomography (PET) using 18-fluorodeoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has proved useful to differentiate malignant from benign tissue and could, therefore, contribute to the evaluation of the SPN. We performed a prospective study of 50 patients referred to the Pneumology Department with unclear diagnoses of SPN after conventional radiological screening. PET study was performed on each subject before an invasive procedure was proposed. Thirty three patients had a malignant nodule and 17 had a benign nodule. The mean size of malignant nodule was 3 cm (range 1.5-4.5 cm). All showed a marked increase in 18-FDG uptake. The mean size of benign nodule was 1.8 cm (range 0.5-3.5 cm). PET imaging showed the absence of 18-FDG uptake and correctly identified 15 of 17 benign nodules. There was two false-positive cases with a moderate increase in 18-FDG uptake (1 postprimary tuberculosis; and 1 anthracosilicotic nodule with nonspecific inflammation). At present, the sensitivity and specificity of the method are 100 and 88%, respectively. The positive and negative predictive values of PET imaging for SPNs are 94 and 100%, respectively. Our preliminary results demonstrate that PET-FDG imaging is a noninvasive technique, which appears highly accurate in differentiating malignant SPN from benign SPN. [less ▲]

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See detailTowards an Integrated Solution for Multimedia Communications
Mathy, Laurent ULg; Leduc, Guy ULg; Danthine, André ULg et al

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1996)

During the last few years, we have been witnessing tremendous changes in the communication environment. Those changes are not only due to the availability of higher data rates in the communication ... [more ▼]

During the last few years, we have been witnessing tremendous changes in the communication environment. Those changes are not only due to the availability of higher data rates in the communication networks but also to the appearance of new application types such as multimedia applications. After a brief introduction to multimedia communications, we will present the research activities in multimedia we have undertaken during the last few years. They focus on two aspects of multimedia communications: a new semantics for expressing Quality of Service (QoS), and a support for group communications. [less ▲]

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See detailL'interdisciplinarité en didactique des langues étrangères : une nouvelle donne pour le FLE ?
Defays, Jean-Marc ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1996), (37/38), 143-157

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See detailLe Szondi des Tarahumaras
Stassart, Martine ULg

in Cahiers du CEP (Centre d'Etudes Pathoanalytiques) (1996), 7(1), 67-74

Tarahumaras live in Northmexican mountains. They maintain jealously their original culture. About 1980, 68 male native Tarahumaras of various ages ( from 5 to 80 years old) were examinated with the ... [more ▼]

Tarahumaras live in Northmexican mountains. They maintain jealously their original culture. About 1980, 68 male native Tarahumaras of various ages ( from 5 to 80 years old) were examinated with the Szonditest. The results do not show any difference between indivuals. Such results agree with the opinion of Szondi about the socalled "primitive" people. [less ▲]

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See detailImportance of the E-46-D-160 Polypeptide Segment of the Non-Penicillin-Binding Module for the Folding of the Low-Affinity, Multimodular Class B Penicillin-Binding Protein 5 of Enterococcus Hirae
Mollerach, Marta E.; Partoune, Pierre; Coyette, Jacques ULg et al

in Journal of Bacteriology (1996), 178(6), 1774-1775

Compared with the other class B multimodular penicillin- binding proteins (PBPs), the low-affinity PBP5 responsible for penicillin resistance in Enterococcus hirae R40, has an extended non-penicillin ... [more ▼]

Compared with the other class B multimodular penicillin- binding proteins (PBPs), the low-affinity PBP5 responsible for penicillin resistance in Enterococcus hirae R40, has an extended non-penicillin-binding module because of the presence of an approximately 110-amino-acid E-46(-)D-160 insert downstream from the membrane anchor. Expression of pbp5 genes lacking various parts of the insert-encoding region gives rise to proteins that are inert in terms of penicillin binding, showing that during folding of the PBP, the insert plays a role in the acquisition of a correct penicillin-binding configuration by the G-364(-)Q-678 carboxy-terminal module. [less ▲]

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See detailLe cas clinique du mois. Syndrome de Moskowitz chez une patiente traitée par ticlopidine
Franchimont, D.; Frere, Pascale ULg; Lebrun, F. et al

in Revue Médicale de Liège (1996), 51(3), 214-6

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See detailIn one step from KC1 to YBa2Cu3O7 crystal growth: Understanding of dendritic morphology in crystals
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg; Cloots, Rudi ULg

in Philosophical Magazine Letters (1996), 73(3), 101-105

A dendritic morphology of crystals is often encountered in nature and seems to be a universal structure for systems grown from supersaturated solutions such as KC1 or NaC1. The observation of similar ... [more ▼]

A dendritic morphology of crystals is often encountered in nature and seems to be a universal structure for systems grown from supersaturated solutions such as KC1 or NaC1. The observation of similar dendrites in bulk superconducting YBa2Cu307 covalent material leads us to correlate the cases. From a simple new kinetics mechanism, the understanding of such a crystal-growth peculiarity is discussed. The kinetic mechanism condition for the occurrence of dendritic shapes of growing crystals from multiphase systems is given through a relationship between the velocity of the growth front and classical thermodynamical quantities. Some simulated systems illustrate the observed features. [less ▲]

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See detailLes convulsions fébriles: attitude actuelle
Misson, Jean-Paul ULg; Leroy, Patricia; Dubru, Jean-Marie ULg

in Tempo Médical (1996)

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See detailGrowth models with internal competition
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg

in Acta Physica Polonica B (1996), 27(3), 737-746

Combined statistical physics and computation modelling give new instruments for the study of non-equilibrium systems. We briefly review generalized Eden and Diffusion-Limited Aggregation models as applied ... [more ▼]

Combined statistical physics and computation modelling give new instruments for the study of non-equilibrium systems. We briefly review generalized Eden and Diffusion-Limited Aggregation models as applied to spreading phenomena. We indicate the occurence of non-universal behaviors. [less ▲]

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See detailL'apport du Szondi à l'Ethnopsychologie
Stassart, Martine ULg

in Cahiers du Cep (Centre d'Etudes Pathoanalytiques) (1996), 7(1), 75-86

The authors have studied with the help of Szonditest a lot of various people ( African, Amerindian, European). They give a summary of these statistical studies. Their interpretation of results agrees with ... [more ▼]

The authors have studied with the help of Szonditest a lot of various people ( African, Amerindian, European). They give a summary of these statistical studies. Their interpretation of results agrees with that of Léopold Szondi [less ▲]

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See detailDifunctional initiator based on 1,3-diisopropenylbenzene. 2. Kinetics and mechanism of the sec-butyllithium/1,3-diisopropenylbenzne reaction
Yu, Y. S.; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecules (1996), 29(5), 1753-1761

Kinetics of the addition of s-butyllithium (s-BuLi) to 1,3-diisopropenylbenzene (1,3-DIB) has been studied, and the activation energy has been found to be 17.5 kcal/mol. Addition of s-BuLi to 1,3-DIB in a ... [more ▼]

Kinetics of the addition of s-butyllithium (s-BuLi) to 1,3-diisopropenylbenzene (1,3-DIB) has been studied, and the activation energy has been found to be 17.5 kcal/mol. Addition of s-BuLi to 1,3-DIB in a 2/1 molar ratio results in an oligomer rather than the desired diadduct. This observation has to be compared to the anionic polymerization of 1,3-DIB (hydrocarbon solvent at 50 °C) which leads to a polymer bearing ca. one double bond per monomeric unit. Li-NMR analysis of the addition of s-BuLi to 1,3-DIB (2/1 molar ratio) confirms the nonequivalence of the lithium cations and shows that ca. 30% s-BuLi remains unreacted when 1,3-DIB has been completely consumed. In the early stage of the addition, the propagation rate is faster than depropagation and the average molecular weight increases. When a depropagation−propagation quasi-equilibrium is reached, the oligomer molecular weight remains constant. It finally decreases when no DIB is left, as a result of depropagation. When the s-BuLi/1,3-DIB adduct is used as an initiator for styrene polymerization in the presence of a polar solvent, such as THF, initiation by monofuntional, difunctional, trifunctional, and tetrafunctional species is observed. In an apolar solvent, however, polystyrene of a narrow molecular weight distribution and a functionality of 2 is formed. This experimental observation more likely indicates that depolymerization of the 1,3-DIB oligomers occurs upon the addition of styrene. A mechanism which accounts for this propagation−depropagation process has been proposed and experimentally supported. [less ▲]

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See detailClONO2 total vertical column abundances above the Jungfraujoch Station, 1986-1994: Long-term trend and winter-spring enhancements
Rinsland, C. P.; Zander, Rodolphe ULg; Demoulin, Philippe ULg et al

in Journal of Geophysical Research (1996), 101(D2), 3891-3899

Total vertical column abundances of chlorine nitrate (ClONO2) have been retrieved from 0.006 cm(-1) resolution solar absorption spectra recorded at the International Scientific Station of the Jungfraujoch ... [more ▼]

Total vertical column abundances of chlorine nitrate (ClONO2) have been retrieved from 0.006 cm(-1) resolution solar absorption spectra recorded at the International Scientific Station of the Jungfraujoch (ISSJ) in the Swiss Alps (altitude 3.58 km, latitude 46.5 degrees N, longitude 8.0 degrees E) on 105 days between June 1986 and November 1994. The analysis is based on spectral fittings of the ClONO2 nu(4) band Q branch at 780.21 cm(-1) and the interferences occurring in the same spectral region. The ISSJ measurements show a regular long-term increase in the ClONO2 column with an occasional factor of 2 to 3 enhancements during the midwinter to early spring. Excluding data from this time of the year, the ISSJ database reflects a linear rate of increase and la uncertainty equal to (4.0 +/- 0.7)% yr(-1) referenced to 1990.0. The corresponding ClONO2 total vertical columns for mid-1986 and mid-1994 are equal to 0.92 and 1.26 x 10(15) molecules cm(-2), respectively. The high ClONO2 columns and high HF/HCl column ratios sometimes measured during winter indicate the occasional presence of chemically processed air above the station. This is corroborated by trajectories calculated for the stratospheric air masses sounded on these occasions. [less ▲]

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See detailSeventeen copies of the human 37 kDa laminin receptor precursor/p40 ribosome-associated protein gene are processed pseudogenes arisen from retropositional events
Jackers, Pascale ULg; Clausse, Nathalie; Fernandez, Maria-Teresa et al

in Biochimica et Biophysica Acta (1996), 1305(1-2), 98-104

A cDNA coding for a 37 kDa polypeptide has been identified in several species as both the potential precursor of the 67 kDa laminin receptor (37LRP) and a putative ribosome-associated protein (p40 ... [more ▼]

A cDNA coding for a 37 kDa polypeptide has been identified in several species as both the potential precursor of the 67 kDa laminin receptor (37LRP) and a putative ribosome-associated protein (p40). Interestingly, increased expression of this polypeptide (37LRP/p40) is consistently observed in invasive and metastatic cancer cells and is associated with poor prognosis. Southern-blot analysis of human genomic DNA predicted multiple copies of the 37LRP/p40 gene. In this study, we report that the number of copies of this sequence in the human genome is 26 +/- 2. We have sequenced and analyzed 19 genomic clones corresponding to the 37LRP/p40 gene and found that they were all processed pseudogenes. They all lack intronic sequences and show multiple genetic alterations leading in some cases to the appearance of stop codons. Moreover, they all bear characteristic features of retroposons as the presence of a poly(A)-tail at their 3' end and short direct repeated flanking DNA sequences. None of the pseudogenes analyzed present cis-elements in their 5' flanking region such as TATA or GC boxes. Our date reveal that over 50% of the 37LRP/p40 gene copies are pseudogenes most probably generated by retropositional events. The finding of multiple pseudogenes for the 37LRP/p40 suggests that the accumulation of several copies of this gene might have given a survival advantage to the cell in the course of evolution. [less ▲]

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See detailComet C/1996 B2 (Hyakutake)
Tichy, M.; Galad, A.; Pravda, A. et al

in Minor Planet Electronic Circulars (1996)

Available from the Minor Planet Center.

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See detailWR22: the most massive Wolf-Rayet star ever weighed.
Rauw, Grégor ULg; Vreux, Jean-Marie ULg; Gosset, Eric ULg et al

in Astronomy and Astrophysics (1996), 306

The results of an extensive spectroscopic campaign on the eclipsing binary WR22 are presented. A new radial velocity curve is deduced for the WN7 component, allowing us to improve the parameters of the ... [more ▼]

The results of an extensive spectroscopic campaign on the eclipsing binary WR22 are presented. A new radial velocity curve is deduced for the WN7 component, allowing us to improve the parameters of the orbit, formerly determined on the basis of photographic spectra. The high signal-to-noise ratio of our data also allows the detection of some weak absorption lines which, for the first time, can definitely be attributed to the companion. A study of their radial velocities gives a mass ratio of m_WR_/m_O_=2.78 leading to a minimum mass of 72M[SUB]sun[/SUB]_ for the WN7 star. The companion can be classified as a "late O" (O6.5-O8.5) star with a luminosity ratio of the system q=L_WR_^y^/L_O_^y^ at 5500A of about 8. The exceptionally high mass of the WN7 star and its high hydrogen mass-fraction suggest that WR22 is at the beginning of its Wolf-Rayet evolution. As a matter of fact, with such a high mass, WR22 most probably is still a hydrogen burning object. Therefore, the WN7 component is much closer to a main sequence O star with a "Wolf-Rayet clothing" than to the other members of the Wolf-Rayet family, which are rather highly evolved He-burning descendants of massive progenitors. [less ▲]

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See detailThe screening of species in a Darwinistic tree-like model of evolution
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physica D: Nonlinear Phenomena (1996), 90(3), 262-270

Numerical and theoretical investigations of a tree-like model of self-organized critical evolution are presented. The screening of species from the evolution process is numerically studied. Critical ... [more ▼]

Numerical and theoretical investigations of a tree-like model of self-organized critical evolution are presented. The screening of species from the evolution process is numerically studied. Critical exponents for (i) the avalanche distribution, (ii) the correlation function, (iii) the order parameter and (iv) the fraction of unscreened species are given. A mean-field approximation is developed. This theory is quite accurate for describing the critical state but is not able to describe the transient regimes, i.e. the self-organized slowing down of both order parameter and fraction of unscreened species towards the critical state. [less ▲]

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See detailExistence of a short period (3.5-4 hours) in the photometric variability of WR 66.
Rauw, Grégor ULg; Gosset, Eric ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (1996), 306

We report here on an independent detection of a short period (~4hours) in the photometric variations of WR66, thus confirming in broad terms the discovery by Antokhin et al.. In addition, we present the ... [more ▼]

We report here on an independent detection of a short period (~4hours) in the photometric variations of WR66, thus confirming in broad terms the discovery by Antokhin et al.. In addition, we present the first spectroscopic variability analysis for this star. A few peculiarities of the spectrum of WR66 are also discussed. Finally, we perform a brief examination of different possible origins of the phenomenon. [less ▲]

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See detailHybridization effects in U2T2X compounds: Magnetic structures of U2Rh2Sn and U2Ni2In
Nakotte, Heinz; Purwanto, A.; Robinson, R. A. et al

in Physical Review. B : Condensed Matter (1996), 53(6), 3263-3271

The tetragonal intermetallic compounds U2Ni2In and U2Rh2Sn have been studied by means of specific-heat, electrical-resistivity, and neutron-diffraction techniques. At low temperatures, both compounds ... [more ▼]

The tetragonal intermetallic compounds U2Ni2In and U2Rh2Sn have been studied by means of specific-heat, electrical-resistivity, and neutron-diffraction techniques. At low temperatures, both compounds order antiferromagnetically in a magnetic unit cell doubled along the c axis, and we find 5f moments of 0.60 and 0.38 Bohr magneton/U atom for U2Ni2In and U2Rh2Sn, respectively. For U2Ni2In, our refinement also indicates a possible Ni moment of 0.37 Bohr magneton perpendicular to the U moments. We discuss the development of the 5f moments together with findings on other isostructural U2T2X (T=transition metal, X=In, Sn) compounds, and confirm that the trends expected due to 5f-ligand hybridization also hold for this family of uranium compounds. Our analysis indicates different arrangements of the 5f moments in the two compounds (noncollinear arrangement within the basal plane for U2Ni2In and collinear arrangement along the c axis for U2Rh2Sn), although both compounds have nearest-neighbor U-U distances along the c axis. This would mean that the magnetocrystalline anisotropy in U2T2X compounds is not determined by nearest-neighbor U-U links alone [less ▲]

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See detailStaging of Non-Small-Cell Lung Cancer by Whole-Body Fluorine-18 Deoxyglucose Positron Emission Tomography
Bury, Thierry ULg; Dowlati, A.; Paulus, Patrick et al

in European Journal of Nuclear Medicine (1996), 23(2), 204-6

Positron emission tomography (PET) using fluorine-18 deoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has been proven useful to differentiate malignant from benign tissue ... [more ▼]

Positron emission tomography (PET) using fluorine-18 deoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has been proven useful to differentiate malignant from benign tissue. We undertook a prospective study in 61 patients to compare the accuracy of whole-body FDG PET and conventional imaging (CI) methods for the staging of non-small-cell lung cancer (NSCLC). CI included chest and abdomen computed tomographic scanning and bone scintigraphy. When CI or PET study suggested metastatic disease, confirmation was obtained by biopsy or clinical or radiological follow-up. As compared to CI, PET correctly changed the N stage in 13 patients (21%) and the M stage in six patients (10%). There were three false-positive and no false-negative distant PET findings. Our preliminary results show that whole-body FDG PET can improve the diagnostic accuracy in the staging of NSCLC. [less ▲]

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See detailMédecins généralistes wallons. Quelles prescriptions aux personnes âgées de plus de 75 ans?
Franck, Jacques ULg; Ludovicy, R.; Taziaut, P. et al

in Revue Médicale de Liège (1996), 51(2), 163-74

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See detailModel-Based Automatic Target Recognition (ATR) System for Forwardlooking Groundbased and Airborne Imaging Laser Radars (LADAR)
Verly, Jacques ULg; Delanoy, Richard L.

in Proceedings of the IEEE (1996), 84(2), 126-163

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See detailReversal of Acute Renal Failure by Kidney Revascularisation
Van Damme, Hendrik ULg; Rorive, Georges ULg; Limet, Raymond ULg

in European Journal of Vascular and Endovascular Surgery (1996), 11(2), 134-9

OBJECTIVES: To assess whether acute renal failure, due to total or subtotal renal artery occlusion, can be reversed by kidney revascularisation. DESIGN: A retrospective review of surgery for kidney ... [more ▼]

OBJECTIVES: To assess whether acute renal failure, due to total or subtotal renal artery occlusion, can be reversed by kidney revascularisation. DESIGN: A retrospective review of surgery for kidney salvage in anuric patients at a University Hospital. METHODS: From 1983 to 1993, eight patients were operated on for occlusive renal artery disease as a cause of acute renal failure, requiring preoperative haemodialysis. On admission the mean serum creatinine was 40 mg/l (354 mumol/dl). The oligoanuria lasted from 12 h to 3 weeks. Renal length of 8 cm or more and visualisation of a patent distal renal artery branches on aortography were arguments that return of renal function could be expected after revascularisation of these non-functioning kidneys. RESULTS: Revascularisation restored immediate urine flow in six cases, with no further need for dialysis in four. Two patients remained oliguric despite successful reperfusion. One of them could be weaned from dialysis after 1 month. Two patients died postoperatively. Five of the eight patients left the hospital with restored renal function. CONCLUSIONS: Patients with acute renal function deterioration due to ischemia of a single or both kidneys can benefit from prompt revascularisation, with significant recovery of renal function in most of them. [less ▲]

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See detailIn Vitro and in Vivo Stimulation of the Murine Immune System by Agm-1470, a Potent Angiogenesis Inhibitor
Antoine, Nadine ULg; Daukandt, M.; Heinen, Ernst ULg et al

in American Journal of Pathology (1996), 148(2), 393-8

AGM-1470, a potent angiogenesis inhibitor, is already engaged in phase I clinical trials because of its effectiveness to restrain tumor growth and its lack of major side effects. Recently, we showed that ... [more ▼]

AGM-1470, a potent angiogenesis inhibitor, is already engaged in phase I clinical trials because of its effectiveness to restrain tumor growth and its lack of major side effects. Recently, we showed that AGM-1470 stimulates in vitro human B lymphocyte proliferation through T lymphocytes. These data prompted us to explore the in vivo effects of AGM-1470 on the immune system in a mouse model. In this study, we showed that AGM-1470, in synergy with phytohemagglutinin, stimulates the proliferation of murine lymphocytes isolated from lymph nodes. This effect was similar to the one observed with human lymphocytes. When injected subcutaneously or intraperitoneally into mice at pharmacological doses, AGM-1470 induced a significant increase of axillary and mesenteric lymph nodes, respectively. Histological and morphological analyses showed that this phenomenon is mostly due to a hyperplasia of the germinal centers. On average, the area of the germinal center of lymph nodes from AGM-1470-treated mice were three times larger than in lymph nodes from control mice. Interestingly, no effect was observed when AGM-1470 was injected subcutaneously into T-deficient nude mice. Our data demonstrate that AGM-1470 stimulates B cell proliferation in vivo as suggested by the in vitro experiments. This effect should be taken into account in the follow-up of patients treated with this molecule and calls for additional studies to determine the biological consequences of such a stimulation on the host immune system. [less ▲]

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See detailContingency severity assessment for voltage security using non-parametric regression techniques
Wehenkel, Louis ULg

in IEEE Transactions on Power Systems (1996), 11(1), 101-111

This paper proposes a novel approach to power system voltage security assessment exploiting nonparametric regression techniques to extract simple, and at the same time reliable, models of the severity of ... [more ▼]

This paper proposes a novel approach to power system voltage security assessment exploiting nonparametric regression techniques to extract simple, and at the same time reliable, models of the severity of a contingency, defined as the difference between pre- and post-contingency load power margins. The regression techniques extract information from large sets of possible operating conditions of a power system screened offline via massive random sampling, whose voltage security with respect to contingencies is pre-analyzed using an efficient voltage stability simulation. In particular, regression trees are used to identify the most salient parameters of the pre-contingency topology and electrical state which influence the severity of a given contingency, and to provide a first guess transparent approximation of the contingency severity in terms of these latter parameters. Multilayer perceptrons are exploited to further refine this information. The approach is demonstrated on a realistic model of a large scale voltage stability limited power system, where it shows to provide valuable physical insight and reliable contingency evaluation. Various potential uses in power system planning and operation are discussed [less ▲]

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See detailAntibiothérapie topique et infections cutanées
Henry, Frédérique ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (1996), 51(2), 160-162

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du ... [more ▼]

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du médicament doit être guidé par son spectre d'activité. Les risques de développement d'une résistance bactérienne et d'une hypersensibilité allergique à l'antibiotique ou à sa base galénique doivent également être pris en considération. [less ▲]

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See detailHet meisje dat ik Ursula noem. Paul van Ostaijens 'Jong landschap' re-revisited
Spinoy, Erik ULg

in Kunst & Cultuur (1996), 29(2), 16-20

This is a rereading of a famous late poem by the Flemish expressionist Paul van Ostaijen.

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See detailMacromolecular engineering of polylactones and polylactides. 21. Controlled synthesis of low molecular weight polylactide macromonomers
Barakat, Ibrahim; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1996), 34(3), 497-502

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See detailGlucoindole Alkaloids from Stem Bark of Strychnos Mellodora
Tits, Monique ULg; Brandt, V.; Wauters, Jean-Noël ULg et al

in Planta Medica (1996), 62(1), 73-4

Three glucoindole alkaloids, dolichantoside (1), strictosidine (2), and palicoside (3), have been identified in the stem bark of Strychnos mellodora (Loganiaceae), collected in Zimbabwe. The chiroptical ... [more ▼]

Three glucoindole alkaloids, dolichantoside (1), strictosidine (2), and palicoside (3), have been identified in the stem bark of Strychnos mellodora (Loganiaceae), collected in Zimbabwe. The chiroptical (CD) data are compared. [less ▲]

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See detailControl of the biodegradation rate of poly(DL-lactide) microparticles intended as chemoembolisation materials
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Journal of Controlled Release (1996), 38(2-3), 109-122

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different ... [more ▼]

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different molecular weight have been combined. The basic concept relies upon the capability of the high molecular weight component (Mn: 65 000) to provide the microspheres with a high mechanical strength, whereas the low molecular weight component (Mn: 3500) should decrease the particle lifetime dramatically. It has been shown that changing the weight ratio of these two components is an efficient way to control the kinetics of the in vitro degradation of poly(DL-lactide) microspheres on the expected time scale. The microspheres have been prepared by the oil-in-water emulsion/evaporation process, and their final polymer content has been compared to the initial composition of the oil phase. They have also been analyzed by differential scanning calorimetry to know whether the two polymers form a monophase blend or not. Kinetics of the in vitro biodegradation has been estimated from the decrease in molecular weight of the constitutive poly(DL-lactide)s, the time-dependency of the microsphere weight and the observation of changes in the morphology by scanning electron microscopy. Progress in the hydrolysis of the ester groups has also been reckoned from the increasing acidity of the incubation medium and associated with the polymer. [less ▲]

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See detailBlood Mononuclear Cells Mobilization and Cytokines Secretion During Prolonged Exercises
Bury, Thierry ULg; Louis, Renaud ULg; Radermecker, Maurice ULg et al

in International Journal of Sports Medicine (1996), 17(2), 156-60

This study was designed to compare the effects of three prolonged exercises varying in their intensity and duration, on blood mononuclear cell mobilization and cytokine secretion (IL1(1)-IL(2)). Seven ... [more ▼]

This study was designed to compare the effects of three prolonged exercises varying in their intensity and duration, on blood mononuclear cell mobilization and cytokine secretion (IL1(1)-IL(2)). Seven healthy subjects underwent three effort trials (45 % VO(2)max during 4 h - 60% VO(2)max during 3 h - 75 % VO(2)max during 2 h) at one-month intervals. Blood samples were drawn before, different times during exercise and also after exercise. Prolonged exercises induced a transient increase in blood mononuclear cells which occurred across all intensity levels. We also observed a significant increase in plasma IL(1) level during exercise which correlates with the exercise intensity. The mean IL(1) level increased up to 2.5 times after the three proposed exercises (p <0.05). Plasma IL(2) level decreased at the end of prolonged exercises irrespective of the exercise intensity. No correlation was observed between blood mononuclear count and cytokine determination. Our data suggest that blood mononuclear cells mobilization is associated but not correlated with alterations of cytokine levels. [less ▲]

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See detailPoetry as Enforcement: Conquering the Muse in Keats's 'Ode to Psyche'
Steyaert, Kris ULg

in Romanticism on the Net (RoN) (1996), 1(1),

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See detailKinking of the Internal Carotid Artery: Clinical Significance and Surgical Management
Van Damme, Hendrik ULg; Gillain, Daniel ULg; Desiron, Quentin ULg et al

in Acta Chirurgica Belgica (1996), 96(1), 15-22

The authors report on 62 surgical corrections for kinking of the internal carotid artery during a 13-year period (1980-1993). This represents 2.8% of all carotid operative procedures (n = 2188) in the ... [more ▼]

The authors report on 62 surgical corrections for kinking of the internal carotid artery during a 13-year period (1980-1993). This represents 2.8% of all carotid operative procedures (n = 2188) in the same period. It always concerned a significant (< 60 degrees) angulation of a redundant internal carotid artery, that in all but 3 cases was associated with atherosclerotic involvement of the carotid bifurcation. The indication to surgery included transient hemispheric or ocular ischaemia in 25.5% of cases, a regressive neurologic deficit in 8%, a minor stroke in 3%, a stroke in evolution in 11%, and non-lateralized cerebral ischaemia in 21%. In 19 patients (31%) it concerned an asymptomatic high degree stenosis. The surgical technique consisted in carotid transposition-reimplantation after eversion endarterectomy in 37 cases, in posterior transverse plication with patch angioplasty in 20 cases, and in segmental excision with venous interposition graft in 5 cases. There was one postoperative death. The morbidity include one ipsilateral non-fatal stroke and 3 transient ischaemic attacks. A complete long-term follow-up (mean duration 3.4 years) is available for 57 patients. The late incidence of stroke is 1.5% per year. The 5-year survival attains 67%. These long-term results are comparable to the outcome of standard endarterectomy in the same institution. The authors discuss the indication, techniques, and outcome of surgical correction of kinked internal carotid artery. They recommend a shortening procedure, often associated with endarterectomy for severely kinked vessels (angulation 60 degrees or less), symptomatic or not. [less ▲]

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See detailCriticality of trapping in a dynamic epidemic model
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Journal of Physics : A Mathematical & General (1996), 29(2), 309-316

We study a simple model mimicking the two-dimensional growth of a solid interface B through a liquid L in presence of particles A which are pushed by the advancing front. The model considers a short-range ... [more ▼]

We study a simple model mimicking the two-dimensional growth of a solid interface B through a liquid L in presence of particles A which are pushed by the advancing front. The model considers a short-range repulsive interaction between the particles and the advancing front (the so-called Uhlmann, Chalmers and Jackson mechanism). As particles are pushed by the advancing front, this leads to the formation of aggregates which are hindrances to the growth and which can be trapped leading to the formation of internal patterns. A transition between indefinitely growing clusters and frozen ones takes place for a critical particle fraction x(c) = 0.560 +/- 0.005 which is larger than the critical fraction of the corresponding epidemic model with static particles. At that critical threshold x, both percolating clusters and internal patterns are numerically found to be fractal with the same dimension D-f = 1.87 +/- 0.03 close to the classical percolation exponent 91/48. The correlation length exponent v is found to be v = 1.34 +/- 0.08 close to the classical percolation exponent 4/3. The criticality of the internal patterns is unexpected. [less ▲]

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See detailHigh Level of Mt-Mmp Expression Is Associated with Invasiveness of Cervical Cancer Cells
Gilles, Christine ULg; Polette, M.; Piette, Jacques ULg et al

in International Journal of Cancer = Journal International du Cancer (1996), 65(2), 209-13

MMP-2 (gelatinase A) has been associated with the invasive potential of many cancer cells both in vitro and in vivo. It is now becoming clear that the activation of this enzyme might be a key step in ... [more ▼]

MMP-2 (gelatinase A) has been associated with the invasive potential of many cancer cells both in vitro and in vivo. It is now becoming clear that the activation of this enzyme might be a key step in tumor invasion. This activation process has been shown to be a membrane-associated pathway inducible by various agents such as collagen type I, concanavalin A or TGF-beta, but its physiological regulation is still largely unresolved. MT-MMP was recently discovered and described as a potential gelatinase-A activator. In the present study, we investigated the expression of MT-MMP (membrane-type metalloproteinase) in cervical cancer cells both in vitro and in vivo. Comparing several in vitro-transformed cervical cell lines, previously shown to display different invasive potentials, our results showed that the ability of cells to overexpress MT-MMP mRNA following ConA induction correlated with their ability to activate gelatinase A and with a highly invasive behavior. Moreover, using immunohistochemistry and in situ hybridization, we found a higher level of MT-MMP expression in invasive cervical carcinoma and lymph node metastases compared to its expression in non-invasive CIN III lesions. Our in vivo observations also clearly demonstrated a cooperation between stromal and tumor cells for the production of MT-MMP. Taken together, our results clearly correlated high level MT-MMP expression with invasiveness, and thus suggested that MT-MMP might play a crucial role in cervical tumor invasion. [less ▲]

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See detailEmpirical study of departures from the excitation equilibrium of FeI in metal-poor stars.
Magain, Pierre ULg; Zhao, G.

in Astronomy and Astrophysics (1996), 305

A detailed analysis of neutral iron lines in a sample of 13 metal-poor dwarfs and subgiants is carried out on the basis of high resolution spectra obtained with the ESO Coude Echelle Spectrometer. The ... [more ▼]

A detailed analysis of neutral iron lines in a sample of 13 metal-poor dwarfs and subgiants is carried out on the basis of high resolution spectra obtained with the ESO Coude Echelle Spectrometer. The deduced iron abundance is found to depend on the excitation potential of the line used, higher excitation lines generally indicating higher abundances. This could be caused by departures from the local thermodynamic equilibrium (LTE) or by temperature inhomogeneities in the stellar atmospheres. The dependency of this effect on the stellar atmospheric parameters is investigated. From the comparison of iron lines with lines of other elements, it is concluded that the low excitation FeI lines are much more affected than the high excitation lines. The consequences of these effects for the classical abundance analyses are examined. It is found that they may explain, at least in part, some previously reported discrepancies between the results of different authors. [less ▲]

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