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See detailLa calcitonine
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (1996), 51(1), 116-9

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See detailLes facteurs de croissance hematopoiétiques
Fillet, Georges ULg

in Revue Médicale de Liège (1996), 51(1), 102-6

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See detailJ03.13 A and B: a new multiply imaged QSO candidate.
Claeskens, Jean-François ULg; Surdej, Jean ULg; Remy, M.

in Astronomy and Astrophysics (1996), 305

Careful analysis of direct R CCD frames obtained for selected Highly Luminous Quasars in March 1993 with the MPI/ESO 2.2m telescope has revealed that the quasar J03.13 consists of at least two point-like ... [more ▼]

Careful analysis of direct R CCD frames obtained for selected Highly Luminous Quasars in March 1993 with the MPI/ESO 2.2m telescope has revealed that the quasar J03.13 consists of at least two point-like components, constituting therefore a new gravitational lens candidate. Follow-up direct imagery of this interesting object with the New Technology Telescope (NTT) + SUSI in February 1994, using the Bessel B, R and Gunn-i filters, tends to confirm the gravitational lens hypothesis. The mean angular separation and magnitude difference between the A & B images are found to be 0.84"+/-0.03" and 2.1+/-0.1mag, respectively. A spatially unresolved, medium resolution spectrum of J03.13, obtained with the NTT + EMMI in February 1994, shows that the QSO has a redshift z=2.55, with Lyalpha and CIV absorptions at z=2.34 and MgII, MgI and FeII absorptions at z=1.085. The latter absorptions might be associated with a sigma=206km/s lens galaxy. B, R and Gunn-i photometric observations of J03.13 during 1994 and 1995 do not show evidence for flux variations exceeding 0.03mag. HST direct imagery with WFPC2 and FOS spectroscopy of J03.13 A & B are planned during cycle 5. [less ▲]

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See detailHistoire et perspective du traitement par diurétiques
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1996), 51(1), 30-34

Les diurétiques ont été utilisés avec succès en clinique depuis plus de 70 ans. Les diurétiques mercuriels ont constitué la première étape importante dans le développement des diurétiques modernes. Ces ... [more ▼]

Les diurétiques ont été utilisés avec succès en clinique depuis plus de 70 ans. Les diurétiques mercuriels ont constitué la première étape importante dans le développement des diurétiques modernes. Ces dernières années, suite au développement de nouvelles options thérapeutiques, les diurétiques ont été décriés en raison de quelques effets secondaires. Cette classe thérapeutique reste cependant un pilier solide et incontournable dans les états de rétention hydrosodée comme par exemple la décompensation cardiaque ou dans l'hypertension artérielle du sujet âgé. Quoi qu'il en soit, le développement de nouveaux diurétiques vit au ralenti en raison de l'acceptation relativement faible de nouvelles molécules, commercialisées pourtant à très faible dose, c'est-à-dire sans action principale sur la volémie. Les modulateurs du transport d'ions, dérivés des structures moléculaires non diurétiques parmi les familles de diurétiques ouvrent cependant des voies intéressantes dans le traitement de maladies diverses. [less ▲]

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See detailExperimental research on the determination of the main parameters affecting the behaviour of reinforced concrete columns under fire conditions
Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg; Bruls, Alois et al

in Magazine of Concrete Research (1996), 48(6), 117-127

The design of reinforced concrete columns under fire conditions is generally made on the basis of national and international recommendations. The CEB/FIP recommendations have been used for many years ... [more ▼]

The design of reinforced concrete columns under fire conditions is generally made on the basis of national and international recommendations. The CEB/FIP recommendations have been used for many years. Recently, in the framework of the Eurocodes, the document ENV 1992-1-2 (Eurocode 2-1-2), Structural fire design, has been approved by Commission CEN/TC250/SC2 of the European Committee for Standardization. In the CEB/FIP documents and in Eurocode 2-1-2 the main part is devoted to design from tabulated data containing the dimensions of the cross-sections and values for the concrete cover. The use of simplified calculation methods is not current practice for concrete elements, while they are widely used in the case of steel. The determination of the temperature distribution in the cross-section does not facilitate the development of a simplified method. Furthermore, in columns there is a wide scatter of experimental results. In order to gain additional information, an extensive experimental research programme on the behaviour of reinforced concrete columns under fire conditions, financially supported by the Belgian Funds for Fundamental Collective Research (FRFC-FKFO), has been performed at the Universities of Liege and Ghent. In this article the results of this research are presented and the influence of the main parameters is analysed. [less ▲]

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See detailNeurophysins in central diabetes insipidus
Legros, Jean-Jacques ULg; Geenen, Vincent ULg

in Hormone Research (1996), 45

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See detailA propos d'un syndrome de Cushing d'origine indéterminée
Geenen, Vincent ULg

in Actualité Médicale Belge (1996), 513

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See detailIpriflavone in prevention and treatment of postmenopausal and senile osteoporosis
Reginster, Jean-Yves ULg

in Osteoporosis News (1996), 4

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See detailMise au point medicale avant gastroplastie: indications et contre-indications.
Scheen, André ULg

in Revue Médicale de Bruxelles (1996), 17(4), 232-5

Because of the common failure of the various medical procedures used for the treatment of morbid obesity, surgeons have searched alternatives among which gastroplasty appears to offer now the best ... [more ▼]

Because of the common failure of the various medical procedures used for the treatment of morbid obesity, surgeons have searched alternatives among which gastroplasty appears to offer now the best efficacy/safety ratio. Such approach has become more and more popular in our country, but success is almost highly variable from patient to patient. A careful medical assessment is necessary before performing gastroplasty. It mainly aims at choosing the appropriate indications (failure of previous well-applied medical therapy, exclusion of any hormonal cause of obesity, presence of complications due to weight excess, ...) and at excluding cardiovascular (unstable coronaropathy, carotid stenosis, ...), digestive (recurrent oesophagitis, ...) or psychiatric contra-indications. Such medical assessment before gastroplasty should allow to increase the success rate and to reduce the incidence of complications after the surgical procedure. [less ▲]

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See detailCompte rendu de P. CONTAMINE, La guerre au Moyen Âge
Marchandisse, Alain ULg

in Moyen Age (Le) (1996), 102

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See detailBiogeography and taxonomy of Apodemus sylvaticus (the woodmouse) in the Tyrrhenian region: Enzymatic variations and mitochondrial DNA restriction pattern analysis
Michaux, Johan ULg; Filippucci, M. G.; Libois, Roland ULg et al

in Heredity (1996), 76(Part 3), 267-277

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown ... [more ▼]

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown in geographical terms. In order to examine the level of genetic relatedness of insular and continental woodmice, 258 animals were caught in 24 localities distributed in Belgium, France, mainland Italy, Sardinia, Corsica and Elba. Electrophoresis of 33 allozymes and mtDNA restriction fragments were performed and a UPGMA dendrogram built from the indices of genetic divergence. The dendrogram based on restriction patterns shows two main groups: 'Tyrrhenian', comprising all the Italian and Corsican animals and 'North-western', corresponding to all the other mice trapped from the Pyrenees to Belgium. Since all the Tyrrhenian mice are similar and well isolated from their relatives living on the western edge of the Alpine chain, they must share a common origin. The insular populations are consequently derived from peninsular Italian ones. From a taxonomic point of view and taking the priority rules into account, we have to invalidate A. s. clanceyi Harrison, 1948 and to consider the Tyrrhenian woodmice as belonging to A. s. milleri de Beaux, 1926, whereas the North-western ones must be referred to as the nominal subspecies. As far as the Elban woodmouse is concerned, at the moment we prefer to keep its present subspecific status because we only studied one animal. [less ▲]

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See detailThe ovarian follicle in cow: in vivo growth and in vitro culture
Beckers, Jean-François ULg; Drion, Pierre ULg; Figueiredo, J. R. et al

in Reproduction in Domestic Animals (1996), 31

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See detailComparative evaluation of impulse oscillometry and a monofrequency forced oscillation technique in clinically healthy calves undergoing bronchochallenges
Reinhold, Petra; MacLeod, D.; Lekeux, Pierre ULg

in Research in Veterinary Science (1996), 61

Multifrequency impulse oscillometry (IOS) was compared with a monofrequency forced oscillation technique (MFO) in calves undergoing experimentally induced bronchoconstriction and subsequent ... [more ▼]

Multifrequency impulse oscillometry (IOS) was compared with a monofrequency forced oscillation technique (MFO) in calves undergoing experimentally induced bronchoconstriction and subsequent bronchodilatation. The dynamic lung compliance (Cdyn) was also measured by conventional methods. For each test, the baseline mean and the responses to saline, a bronchoconstrictive agent (carbachol) and a bronchodilator (fenoterolhydrobromide) were calculated. Using the IOS, the information was markedly frequency-dependent. The resistance (R) and the magnitude of respiratory impedance (Z) were only sensitive at 5 Hz, leading to negative frequency dependence of these parameters as an indicator of peripheral airway obstruction. A high sensitivity for reactance (X) and phase angle phi values was observed between 5 and 20 Hz. For MFO (10 Hz), the parameters Ros (which includes resistive and capacitive components of the respiratory system), phase shift (psi), and the oscillatory derived compliance of the respiratory system (Crs) were of the greatest clinical potential. Crs showed a significant coefficient of linear correlation (r = 0.88, P < 0.001) with Cdyn. At the 10 Hz test frequency similar results were observed with MFO and IOS, suggesting that for healthy calves the measurement effect of an impulse is not significant. With respect to peripheral airway calibre, a test frequency less than 10 Hz appeared to be most sensitive and least variable. [less ▲]

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See detailEtude des groupements de macrophytes vasculaires aquatiques de la Semois en rapport avec la qualité globale des eaux et du milieu
Thoen, Daniel ULg; Roussel, Laurence; Nicolas, Jacques ULg

in Ecologie (1996), 27(4), 223-232

Les groupements de macrophytes aquatiques de la Semois (ca. 200 km de long) ont été décrits par l'analyse de 218 relevés de végétation réalisés durant l'année 1994. De l'amont vers l'aval, six groupements ... [more ▼]

Les groupements de macrophytes aquatiques de la Semois (ca. 200 km de long) ont été décrits par l'analyse de 218 relevés de végétation réalisés durant l'année 1994. De l'amont vers l'aval, six groupements végétaux ont été caractérisés. Deux zones principales peuvent être distinguées. Dans la zone amont, la végétation potentielle a été détruite ou remplacée par des groupements végétaux, plus résistants à la pollution organique et aux modifications physiques du milieu: groupement à Sparganium emersum et Potamogeton nanans; association à Potamogeton pectinatus. Dans la zone aval, la présence de groupements relevant du Ranunculetum fluitantis est plus conforme à la végétation potentielle et indique de meilleures conditions du milieu. Une analyse canonique des correspondances, sur les principales espèces aquatiques et les paramètres physico-chimiques de l'eau de 40 stations, a permis de regrouper des espèces présentant des affinités écologiques entre elles et de dégager leurs valeurs indicatrices relatives pour certains paramètres abiotiques. [less ▲]

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See detailEndometrial laser interstitial hyperthermy: a potential modality for endometrial ablation.
Donnez, Jacques; Polet, Roland; Mathieu, Pierre-Emmanuel et al

in Obstetrics & Gynecology (1996), 87(3), 459-64

This study was undertaken to evaluate the efficacy and safety of an intrauterine device designed for endometrial ablation by Nd-YAG laser interstitial hyperthermy. Eight hysterectomy specimens were ... [more ▼]

This study was undertaken to evaluate the efficacy and safety of an intrauterine device designed for endometrial ablation by Nd-YAG laser interstitial hyperthermy. Eight hysterectomy specimens were treated in vitro with an output power of 30 W for 5 minutes; tissue temperatures, recorded by thermocouples, were plotted to draw time-temperature and time-distance curves. As a preliminary series, ten patients were treated, with the first five subjected to local temperature monitoring; all ten were followed-up for 6-17 months. Immediate and delayed (6 weeks) histologic data were obtained. The intramural temperature at 6 mm from the fibers ranged from 55-60C). In vivo, the cooling effect of the arterial blood flow lowered the serosal temperatures under 41C. The histologic data and the hysterographic pictures suggest that endometrial ablation was effective. This new device does not require distending medium, hysteroscopic control, or high-powered Nd-YAG laser machines. Preliminary long-term results suggest that the device could be used for endometrial ablation. [less ▲]

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See detailCes histoires que l'on construit et que l'on se raconte...
Guillaume, Jean-François ULg

in Cahiers Internationaux de Sociologie (1996), 100

A partir des réflexions de Paul Ricoeur sur la temporalité et la narrativité, l'A. envisage les processus discursifs de construction identitaire chez les jeunes gens en fin de scolarité obligatoire. L ... [more ▼]

A partir des réflexions de Paul Ricoeur sur la temporalité et la narrativité, l'A. envisage les processus discursifs de construction identitaire chez les jeunes gens en fin de scolarité obligatoire. L'identité en construction est appréhendée à travers le récit qu'ils donnent de leurs projets d'avenir et de leur histoire familiale. La présentation de soi, perçue dans cette double dimension, est soumise à un ensemble de schèmes ou de modèles narratifs culturellement ancrés et socialement véhiculés. Elle prend forme et se constitue en une totalité cohérente et intelligible par une « mise en intrigue » de la diversité des péripéties vécues ou imaginées. [less ▲]

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See detailVoltage stability analysis in transient and mid-term time scales
Van Cutsem, Thierry ULg; Vournas, Costas

in IEEE Transactions on Power Systems (1996), 11

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See detailSelection of hammerhead ribozymes for optimum cleavage of interleukin 6 mRNA.
Hendrix, Chris; Anne, J; Joris, Bernard ULg et al

in Biochemical Journal (1996), 314 ( Pt 2)

Four GUC triplets in the coding region of the MRNA of interleukin 6 (IL-6) were examined for their suitabilty to serve as a target for hammerhead ribozome-mediated cleavage. This selection procedure was ... [more ▼]

Four GUC triplets in the coding region of the MRNA of interleukin 6 (IL-6) were examined for their suitabilty to serve as a target for hammerhead ribozome-mediated cleavage. This selection procedure was performed with the intention to downregulate IL-6 production as a potential treatment of those diseases in which IL-6 overexpression is involved. Hammerhead ribozymes and their respective short synthetic substrates (19-mers) were synthesized for these four GUC triplets. Notwithstanding the identical catalytic core sequences, the difference in base composition of the helices involved in substrate binding caused substantial variation in cleavage activity. The cleavage reactions on the 1035 nucleotide IL-6 mRNA transcript revealed that two ribozymes were able to cleave this substrate, showing a decrease in catalytic efficiency to 1/30 and 1/300 of the short substrate. This study indicates that the GUC triplet located at nucleotide 510 of the mRNA of IL-6 is the best site for hammerhead ribozyme-mediated cleavage. We suggest that in future targeting of chemically modified hammerhead ribosomes for cleavage of IL-6 RNA should be directed at this location. [less ▲]

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See detailThe tilapia prolactin I gene: evolutionary conservation of the regulatory elements directing pituitary-specific expression
Poncelet, A. C.; Levavi-Sivan, B.; Muller, Marc ULg et al

in DNA & Cell Biology (1996), 15(8), 679-92

To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately ... [more ▼]

To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately upstream from the first exon. In footprinting experiments, three tilapia sequences are protected from DNase I digestion by rat pituitary extracts (base pair coordinates -643 to -593, -160 to -111, and -73 to -46). Computer analysis of the nucleotide sequence reveals significant homology to mammalian binding sites for Pit-1, a transcription factor that is known to mediate pituitary-specific expression of the PRL genes in mammals. The tiPRL I 5'-flanking sequences can direct transient expression of a linked luciferase reporter gene in transfected rat pituitary cell lines and tilapia pituitary primary cell cultures. Transient expression experiments with 5'-deletion mutants reveal three regulatory regions. Two have a stimulatory effect on transcription and one an inhibitory effect. Electrophoretic mobility-shift assays (EMSA) demonstrate that the rat Pit-1 factor specifically binds to tilapia DNA sequences. Several such tilapia Pit-1 binding sites mediate activation of a linked heterologous promoter in transfected rat and tilapia pituitary cells. As evidenced by EMSA, a Pit-1-like protein is present in tilapia pituitary extracts. All these data point to a high conservation of the molecular mechanisms involved in pituitary-specific expression of the PRL genes in vertebrates. [less ▲]

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See detailClimatology
Erpicum, Michel ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1996), 64 (2)

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See detailCrystallization and preliminary X-ray diffraction studies of a-amylase from the antarctic psychrophile Alteromonas haloplanctis A23
Aghajari, N.; Feller, Georges ULg; Gerday, Charles ULg et al

in Protein Science : A Publication of the Protein Society (1996), 5(10), 2128-2129

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the ... [more ▼]

A cold-active alpha-amylase was purified from culture supernatants of the antarctic psychrophile Alteromonas haloplanctis A23 grown at 4 degrees C. In order to contribute to the understanding of the molecular basis of cold adaptations, crystallographic studies of this cold-adapted enzyme have been initiated because a three-dimensional structure of a mesophilic counterpart, pig pancreatic alpha-amylase, already exists. alpha-Amylase from A. haloplanctis, which shares 53% sequence identity with pig pancreatic alpha-amylase, has been crystallized and data to 1.85 A have been collected. The space group is found to be C222(1) with a = 71.40 A, b = 138.88 A, and c = 115.66 A. Until now, a three-dimensional structure of a psychrophilic enzyme is lacking. [less ▲]

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See detailLe fonctionnement de la mémoire à court terme auditive-vocale dans le syndrome de Down : Implications pour le modèle de mémoire de travail
Comblain, Annick ULg

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (1996), 8(4-5), 137-147

Since the end of the sixties, number of studies have put in obviousness that the short-term memory span of mentally retarded subjects remains largely below the level expected regarding their mental age ... [more ▼]

Since the end of the sixties, number of studies have put in obviousness that the short-term memory span of mentally retarded subjects remains largely below the level expected regarding their mental age and their chronological age. Mackenzie and Hulme (1987) and Hulme and Mackenzie (1992), for example, showed that verbal short-term memory abilities of mentally retarded subjects do not develop at the same rate than other cognitives aspects. These results provide important information on the development of memory span in those subjects but do not provide information on the functioning of the different components of their verbal short-term memory. We conducted several experiments in order to supply with this deficit and to describe the functioning of the verbal short-term memory in a group of Down's syndrome subjects. Our data put in obviousness the similarity of verbal short-term memory's functioning in Down's syndrome subjects and in normal children (phonological similarity effect and word length effect). The absence of a significant correlation between articulation rate and memory span in Down's syndrome people (like in less than 6 years old normal children, see Gathercole et al., 1993, 1994) leads us to discuss a central point of the working memory model (Baddeley, 1986). [less ▲]

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See detailPrimary Systemic Amyloidosis - A report of 2 cases
Dezfoulian, Bita ULg; Arrese Estrada, Jorge ULg; Fernandez, A. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1996), 192

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection ... [more ▼]

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection, inflammation, neoplasms and paraproteinemia was conclusively negative in the other patient. The recognition of cutaneous signs of primary systemic amyloidosis is crucial to insure a rapid management aimed at postponing the fatal issue of the disease. [less ▲]

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See detailCombined Liver - Spleen -small intestine grafting in a rat model: Role of transplanting additional lymphoid tissue on survival.
D'Silva, Milbhor; Pirenne, Jacques; Nakhleh, R. E. et al

in International Surgery (1996), (81), 109-114

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See detailAntimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Wright, C. W.; Phillipson, J. D.; Awe, S. O. et al

in Phytotherapy Research (1996), 10

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar ... [more ▼]

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day. [less ▲]

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See detailModelling the North Sea hydrodynamics in a management perspective
Djenidi, Salim ULg; Delhez, Eric ULg; Martin, Géraldine ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailHeparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells.
Incardona, F.; Lawler, J.; Cataldo, Didier ULg et al

in Journal of Cellular Biochemistry (1996), 62(4), 431-42

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains ... [more ▼]

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains of thrombospondin that mediate its binding to specific receptors on the human breast adenocarcinoma cell line, MDA-MB-231. Two recombinant fragments from the amino-terminus (TSPN18 and TSPN28), and the fusion proteins of the type 1 and type 2 repeats of human thrombospondin, inhibited binding of radiolabeled thrombospondin to MDA-MB-231 cells in suspension by 40-60% at 50 micrograms/ml whereas the type 3 repeat, carboxy-terminus and unfused glutathione-S-transferase as well as the synthetic peptide Gly-Arg-Gly-Asp-Ser (500 micrograms/ml) had little or no effect. Heparin and various glycosaminoglycans as heparan sulfate, chondroitin sulfates A, B or C, and fucoidan inhibited thrombospondin binding to MDA-MB-231 cells by more than 60% whereas dextran sulfate had only little effect. Treatment of cells with heparitinase, chondroitinase ABC, and hyaluronidase, but not with neuraminidase, induced 30-50% inhibition of thrombospondin binding suggesting the participation of both heparan sulfate and chondroitin sulfate cell surface-associated molecules. Inhibition of proteoglycan sulfation by chlorate or inhibition of glycosaminoglycan chain formation by two beta-D-xylosides also led to a substantial inhibition of thrombospondin binding. Our results indicate that several domains within the thrombospondin molecule, namely the amino-terminus, type 1 and type 2 repeats, participate in its binding to specific receptors bearing sulfated glycosaminoglycans on MDA-MB-231 cells. Biological assays have indicated that, in addition to these domains, the peptide Gly-Arg-Gly-Asp-Ser inhibited MDA-MB-231 cell attachment to thrombospondin suggesting that the last type 3 repeat of the molecule may also contribute to its cell adhesive activity. [less ▲]

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See detailEtude dynamographique de la marche de l'hémiplégique: effets de différentes modalités d'électrostimulation
Vanderthommen, Marc ULg; Lucas, C.; Laurent, J.M. et al

in Kine Acta-Symposium (1996)

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See detailThe effects of dietary crude protein on growth of the Eurasian perch Perca fluviatilis
Fiogbe, E. D.; Kestemont, P.; Mélard, Charles ULg et al

in Aquaculture (1996)

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See detailPersistency of lactation yields: A review
Gengler, Nicolas ULg

in Interbull Bulletin (1996), 12

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See detailCodon adjustment to maximise heterologous gene expression in Streptomyces lividans can lead to decreased mRNA stability and protein yield.
Lammertyn, E; Van Mellaert, L; Bijnens, A P et al

in Molecular & General Genetics [=MGG] (1996), 250(2), 223-9

The impact of the codon bias of the mouse tumour necrosis factor alpha (mTNF) gene cloned in Streptomyces lividans on the efficiency of expression and secretion was analysed. Minor codons occurring in the ... [more ▼]

The impact of the codon bias of the mouse tumour necrosis factor alpha (mTNF) gene cloned in Streptomyces lividans on the efficiency of expression and secretion was analysed. Minor codons occurring in the mTNF gene were therefore adapted to the codon bias of Streptomyces by site-directed mutagenesis. No improvement in mTNF yield could be detected. The stability of the transcript derived from the construct was shown to be more important for determining the final level of mTNF production. A strong correlation was observed between the yield of secreted biologically active mTNF and the amount of mTNF mRNA present in the cells. [less ▲]

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See detailA double-blind, three-week study to compare the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis.
REGINSTER, Jean-Yves ULg; Distel, M.; Bluhmki, E.

in British Journal of Rheumatology (1996), 35(Suppl 1), 17-21

A multicentre, double-blind, randomized study was conducted in patients with rheumatoid arthritis (RA) in order to compare the efficacy and safety of two different doses of meloxicam, a new preferential ... [more ▼]

A multicentre, double-blind, randomized study was conducted in patients with rheumatoid arthritis (RA) in order to compare the efficacy and safety of two different doses of meloxicam, a new preferential cyclooxygenase-2 (COX-2) inhibitor. Four hundred and twenty-three patients were randomized to receive once-daily oral meloxicam 7.5 mg (n = 216) or meloxicam 15 mg (n = 207) for 3 weeks. The Ritchie joint index and pain in the morning were significantly improved versus baseline (P < 0.001) in both groups. There were no significant differences between the effects of each dose with respect to these measures nor with respect to final assessment of global efficacy by the patients. However, the 15 mg dose was associated with a significantly (P < 0.05) better effect on morning stiffness and grip strength. No differences between the doses were observed with regard to the other secondary efficacy parameter (pain at night, body weight and erythrocyte sedimentation rate). Both doses of meloxicam were well tolerated. There were no differences between the doses with respect to global tolerance as assessed by the patient and the patients, 'general condition'. In conclusion, meloxicam at a once-daily dose of either 7.5 or 15 mg is well tolerated and effective in the treatment of patients with RA. [less ▲]

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See detailStable isotope studies: a remarkable tool in delianating organic matter pathways between pelagic and benthic realms. In memoriam Fiorentina Mosora
Mosora, Fiorentina; Dauby, Patrick ULg

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailAnalyse de "La Mort" de Maurice Carême
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1996), 29

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See detailSerum erythropoietin in chronic lymphocytic leukaemia.
Beguin, Yves ULg; Lampertz, S.; Bron, D. et al

in British Journal of Haematology (1996), 93(1), 154-6

Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured ... [more ▼]

Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured serum Epo levels in 47 CLL patients to determine whether Epo was a significant factor in the development of their anaemia. Epo levels were increased compared to normal individuals and this elevation appeared adequate for the degree of anaemia. The slope of the regression of Epo versus haemoglobin (Hb) was similar to that of a reference group. Serum transferrin receptor (sTfR) levels were also appropriately elevated for the degree of anaemia and correlated with serum Epo. Advanced stage was not associated with reduction of Epo production but diminished erythropoietic activity was observed in several patients. The results indicate that anaemia in CLL is not characterized by inadequate Epo production. [less ▲]

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See detailUse of the monofrequency forced oscillation technique to measure changes in upper airway resistance in Friesian and blue Belgian calves
Reinhold, Petra; Genicot, Bruno; Close, Roland et al

in Research in Veterinary Science (1996), 61(3), 227-230

Monofrequency forced oscillometry (MFO) using a sinusoidal test signal of one frequency (10 Hz) was compared with the classical pulmonary function technique (using an oesophageal balloon with airflow ... [more ▼]

Monofrequency forced oscillometry (MFO) using a sinusoidal test signal of one frequency (10 Hz) was compared with the classical pulmonary function technique (using an oesophageal balloon with airflow measurements) in two breeds of cattle which differ in their respiratory physiology, particularly to assess changes in upper airway resistance. Six healthy male Friesian calves (mean [SD] bodyweight 131 [12] kg) and six healthy male blue Belgian calves (mean [SD] bodyweight 137 [13] kg) were examined successively with their heads either in a normal position or held vertically, using a cross-over study design. In the normal position, higher resistances, a higher respiratory impedance, and lower values of the dynamic lung compliance (Cdyn) were measured in the blue Belgian than in the Friesian calves. In the vertical head position, total pulmonary resistance (RL) increased and Cdyn decreased significantly (P < 0.05). The changes in MFO-derived parameters were in accordance with the changes in classical parameters, and for both methods, the percentage changes were markedly higher in the blue Belgian calves. [less ▲]

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See detailGenome mapping of Clostridium perfringens strains with I-Ceul shows many virulence genes to be plasmid-borne.
Katayama, S.; Dupuy, B.; Daube, Georges ULg et al

in Molecular & General Genetics [=MGG] (1996), 251

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See detailPeritoneal endometriosis and "endometriotic" nodules of the rectovaginal septum are two different entities.
Donnez, Jacques; NISOLLE, Michelle ULg; Smoes, Pierre et al

in Fertility and Sterility (1996), 66(3), 362-8

OBJECTIVES: To compare histologically and stereologically the endometriotic nodule of the rectovaginal septum to peritoneal endometriosis. DESIGN: Morphometric investigation, cytokeratin and vimentin ... [more ▼]

OBJECTIVES: To compare histologically and stereologically the endometriotic nodule of the rectovaginal septum to peritoneal endometriosis. DESIGN: Morphometric investigation, cytokeratin and vimentin content, and steroid receptor evaluation were performed on endometriotic tissue from the peritoneum (n = 52) and rectovaginal nodules (n = 68). SETTING: An academic teaching hospital. PATIENTS: Biopsies were taken from 120 patients undergoing a laparoscopy for infertility and/ or pelvic pain (52 from typical black peritoneal endometriotic implants and 68 from endometriotic nodule of the rectovaginal septum). None of the patients were treated. RESULTS: Mitotic activity was found to be significantly different in peritoneal and rectovaginal endometriosis. The evaluation suggested that the stroma is not mandatory for the invasion of glandular epithelium in the rectovaginal nodule, which is, like a adenomyoma, a circumscribed nodular aggregate of smooth muscle and glandular elements. Cytokeratin and vimentin content as well as the estrogen receptor (ER) and P receptor (PR) content were significantly lower in both types of lesion when compared with eutopic endometrium. But vimentin immunoreactivity in epithelium, as well as the ER and PR content, were significantly lower in nodules when compared with black peritoneal lesions. CONCLUSION: It is suggested that the rectovaginal endometriotic nodule is a different disease from peritoneal endometriosis and must be called rectovaginal adenomyosis or rectovaginal adenomyoma. Its histopathogenesis probably is not related to the implantation of regurgitated endometrial cells but to the metaplasia of Müllerian rests. [less ▲]

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See detailSpontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome.
Beguin, Yves ULg; Collignon, Jacques ULg; Laurent, C. et al

in British Journal of Haematology (1996), 94(3), 507-9

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a ... [more ▼]

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a relapse of his MDS with complete disappearance of donor haemopoiesis. After two episodes of CMV pneumonia and continued prophylactic use of ganciclovir thereafter, he experienced a spontaneous complete disappearance of all signs of MDS, including myelofibrosis, and a complete return to donor haemopoiesis. This case is the first one to suggest a graft-versus-leukaemia effect (GVL) in MDS patients. It depicts the complex relationship between GVL, graft-versus-host disease (GVHD) and graft rejection. It could also constitute a clinical illustration of the possible antileukaemic effect of CMV infection and its treatment with ganciclovir. [less ▲]

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See detailCompte rendu de Le clerc séculier au Moyen Age, Paris, 1993
George, Philippe ULg

in Cahiers de Clio (1996)

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See detailThe attenuated V60 strain of channel catfish virus possesses a deletion in ORF50 coding for a potentially secreted glycoprotein
Vanderheijden, NATHALIE; Alard, PHILIPPE; Lecomte, CORINE et al

in Virology (1996), 218(2), 422-6

A wild-type strain of channel catfish virus was compared at the genomic level with the attenuated strain V60. In addition to several minor differences, restriction mapping revealed one major deletion ... [more ▼]

A wild-type strain of channel catfish virus was compared at the genomic level with the attenuated strain V60. In addition to several minor differences, restriction mapping revealed one major deletion (approximately 1200 bp) in ORF50 of the V60 strain. Cloning and sequencing of part of this ORF confirmed the presence of a 1164-bp deletion. It should result in a protein of 282 amino acids instead of 670. The predicted truncated protein lacks most of a threonine-rich, highly repetitive region in its central part. Since the protein encoded by ORF50 possesses a hydrophobic N-terminal leader sequence and no membrane anchor sequence, we suggest that it could be a secreted glycoprotein. This protein might be N-glycosylated (35 potential sites) and, given the repetitive arrangement of its residues (mainly threonines), also heavily O-glycosylated like the mucin-type glycoproteins. The deletion observed in ORF50 of the V60 strain implies the loss of 24 potential N-glycosylation sites and should considerably reduce the extent of O-glycosylation. [less ▲]

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See detailMorphometric, immunohistological and three-dimensional evaluation of the endometrium of menopausal women treated by oestrogen and Crinone, a new slow-release vaginal progesterone.
Casanas-Roux, Françoise; NISOLLE, Michelle ULg; Marbaix, Etienne et al

in Human Reproduction (1996), 11(2), 357-63

Recently advanced computerized technology was applied to the investigation of morphometric, immunohistological and three-dimensional changes of the endometrial mucosa in order to evaluate quantitatively ... [more ▼]

Recently advanced computerized technology was applied to the investigation of morphometric, immunohistological and three-dimensional changes of the endometrial mucosa in order to evaluate quantitatively the effects of three doses of a new slow-release vaginal progesterone on the endometrium in post-menopausal women. A total of 20 menopausal women, deprived of ovarian function, were given oestrogen for 12 days and a combined therapy of oestrogen (administered orally) and progesterone for another 12 day period. Progesterone was administered vaginally through a new gel (Crinone) utilizing a bioadhesive, biocompatible polymer as a base to achieve a sustained release effect. An endometrial biopsy was taken before treatment, after oestrogen-only treatment and after the oestro-progestogen therapy. Before treatment, all the patients exhibited an atrophic endometrium. After oestrogen-only treatment, typical proliferative changes occurred: an increase in the endometrium thickness, an increase in the mitotic index, numerous cylinder-like glands and no coiled glands, and high concentrations of oestrogen receptors (ER) and progesterone receptors (PR). After the oestro-progestogen therapy, whatever the dose of progesterone given, a secretory transformation of the endometrial mucosa occurred, mitotic activity decreased significantly, more ramified and coiled glands were observed, and a decrease in PR content was noted in epithelial and stromal nuclei, and a decrease in PR content was also observed in epithelial nuclei but not in stromal nuclei. Accurate new techniques of image analysis have shown that crinone therapy could eliminate the proliferative effects of oestrogen treatment in post-menopausal women, despite doses as low as 45 mg of progesterone administered vaginally every other day. The results suggest that the sustained release effects of Crinone are clinically relevant. [less ▲]

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See detailEffets toxiques de l’ozone atmosphérique sur le système respiratoire. Brève revue des connaissances actuelles
Delaunois, A.; Gustin, Pascal ULg; Nemmar, R. et al

in Annales de Médecine Vétérinaire (1996), 140

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See detailAnalyse cinématographique de la marche électro assistée de l'hémiplégique
Vanderthommen, Marc ULg; Bauval, A.; Crielaard, Jean-Michel ULg

in Kine Acta-Symposium (1996)

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See detailThree hTIM mutants that provide new insights on why TIM is a dimer
Mainfroid, Véronique; Terpstra, Peter; Beauregard, Marc et al

in Journal of Molecular Biology (1996), 257(2), 441-56

Human triosephosphate isomerase (hTIM), a dimeric enzyme, was altered by site-directed mutagenesis in order to determine whether it can be dissociated into monomers. Two hTIM mutants were produced, in ... [more ▼]

Human triosephosphate isomerase (hTIM), a dimeric enzyme, was altered by site-directed mutagenesis in order to determine whether it can be dissociated into monomers. Two hTIM mutants were produced, in which a glutamine residue was substituted for either Met14 or Arg98, both of which are interface residuces. These substitutions strongly interfere with TIM subunit association, since these mutant TIMs appear to exist as compact monomers in dynamic equilibrium with dimers. In kinetic studies, the M14Q mutant exhibits significant catalytic activity, while the R98Q enzyme is inactive. The M14Q enzyme is nevertheless much less active than unmutated hTIM. Moreover, its specific activity is concentration dependent, suggesting a dissociation process in which the monomers are inactive. In order to determine the conformational stability of the wild-type and mutant hTIMs, unfolding of all three enzymes was monitored by circular dichroism and tryptophan fluorescence spectroscopy. In each case, protein stability is concentration dependent, and the unfolding reaction is compatible with a two-state model involving the native dimer and unfolded monomers. The conformational stability of hTIM, as estimated according to this model, is 19.3 (+/-0.4) kcal/mol. The M14Q and R98Q replacements significantly reduce enzyme stability, since the free energies of unfolding are 13.8 and 13.5 (+/- 0.3) kcal/mol respectively, for the mutants, A third mutant, in which the M14Q and R98Q replacements are cumulated, behaves like a monomer. The stability of this mutant is not concentration-dependent, and the unfolding reaction is assigned to a transition from a folded monomer to an unfolded monomer. The conformational stability of this double mutant is estimated 2.5 (+/-0.1) kcal/mol. All these data combined suggest that TIM monomers are thermodynamically unstable. This might explain why TIM occurs only as a dimer. [less ▲]

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See detailCompte rendu de J.-L. LEMAITRE, Le Limousin monastique
George, Philippe ULg

in Moyen Age (Le) (1996)

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See detailErythropoietin and the anemia of cancer.
Beguin, Yves ULg

in Acta Clinica Belgica (1996), 51(1), 36-52

The pathogenesis of the anemia of cancer involves the combination of a shortened erythrocyte survival in circulation with the failure of bone marrow to increase red cell production in compensation ... [more ▼]

The pathogenesis of the anemia of cancer involves the combination of a shortened erythrocyte survival in circulation with the failure of bone marrow to increase red cell production in compensation. Inappropriate red cell production is itself related to a conjunction of factors, including impaired availability of reticuloendothelial storage iron, inadequate erythropoietin (Epo) response to anemia, and overproduction of cytokines which are capable of inhibiting erythropoiesis. Many of these cytokines may interfere with erythropoietin production by the kidney. Consequently inadequate serum erythropoietin levels are often encountered in cancer patients, though more frequently in those with solid tumors or multiple myeloma than in those with other hematologic malignancies. There is little evidence supporting a negative impact of chemotherapy, including cisplatin, on erythropoietin production. Rather, chemotherapy usually causes a transient elevation of serum Epo. Red cell transfusions are often administered to cancer patients, possibly resulting, among other deleterious effects, in enhancement of tumor growth. Recombinant human erythropoietin (rHuEpo) has thus been proposed as an alternative. RHuEpo has been shown to be safe and effective in correcting the anemia of cancer and reducing the need for transfusions. The response rate is as good in hematologic malignancies as in solid tumors, but it is extremely poor in those with myelodysplastic syndromes. The effect of rHuEpo does not differ among patients receiving or not receiving chemotherapy, including cisplatin. The probability of response is also similar in patients with adequate or inappropriate erythropoietin production before therapy, although the doses used are usually 2 to 3 times higher than in renal failure patients. [less ▲]

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See detailLa Grotte du Bois Laiterie, du Magdalénien au Mésolithique: différences comportementales
López Bayón, Ignacio; Straus, Lawrence; Otte, Marcel ULg et al

in Notae Praehistoricae (1996), 16

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See detailEtude de la fiabilité d'un nouvel analyseur de lactate portable chez le cheval
Meynie, J.; Art, Tatiana ULg; Olaerts, J. et al

in Pratique Vétérinaire Equine (1996), 28(1), 37-40

A new portable lactate analyzer has been tested for its accuracy and reproducibility. Venous blood has been sampled on 12 horses while they were performing a treadmill exercise. A total of 134 samples ... [more ▼]

A new portable lactate analyzer has been tested for its accuracy and reproducibility. Venous blood has been sampled on 12 horses while they were performing a treadmill exercise. A total of 134 samples were obtained and analyzed either with the portable analyzer or with a reference method. The packed cell volume has been also determined for each sample. The results obtained with both methods were compared : the correlation between the two sets of data was satisfactory ((R2 = 0,86) but higher when the PCV was lower or equal to 55 % (R2 = 0,88). It was concluded that the portable analyzer is reliable for lactate determination in horses [less ▲]

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See detailThe current situation of wild mammals in Belgium: an outline
Libois, Roland ULg

in Hystrix: the Italian Journal of Mammalogy (1996), 8(1-2), 35-41

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better ... [more ▼]

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better understanding of the current status of the different species. Conservation measures were olso proposed to the political authorities who thereafter edicted a legal protection of the most vulnerable species. Unfortunately, habitat protection is rather unachieved and the situation of the most endangered species is still getting worse. [less ▲]

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See detailcompte rendu de A. Fraschetti, Rome et le prince. Traduction française par V. Jolivet, Paris, 1994
Rochette, Bruno ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1996), 9

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See detailRadiative Lifetimes for States in Cu I
Biémont, Emile ULg; Fryczynski, F.; Palmeri, P. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (1996), 55

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See detailObesity in children. Environmental and genetic Aspects
Guillaume, Michèle ULg; Bjorntorp, P.

in Hormone and Metabolic Research. Supplement Series (1996), 28

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See detailYounger age as a bad prognostic factor in patients with carcinoma of the cervix.
Delaloye, J-F; Pampallona, S; COUCKE, Philippe ULg et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (1996)

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre ... [more ▼]

Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre Hospitalier Universitaire Vaudois of Lausanne were subdivided according to the following age categories: _<45, 46-60, 61-69 and > 70 years. Taking the 46-60 years age group as the reference, the hazard ratios (HR) of death and corresponding 95% confidence intervals (95% CI) were estimated by means of a Cox multivariate analysis. Results: The 5-year survival rates were, respectively, 57%, 67%, 60% and 45%. For the youngest women the risk of death was significantly increased (HR = 2.00, 95% CI [1.32-3.00]) and was even more accentuated in advanced stages. Conclusion: Age under 45 years is a bad prognostic factor in carcinoma of the cervix. [less ▲]

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See detailDe la patria potestas (puissance paternelle) à l'autorité parentale
Gerkens, Jean-François ULg

in L'enfant, avenir des droits de l'homme (1996)

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See detailStorm surges in the Arabian/Persian Gulf
Djenidi, Salim ULg; Neuberg, Luc

in Bulletin de la Société Royale des Sciences de Liège (1996), 65

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See detailLes populations de rats noirs insulaires de l'ouest de l'Europe. Essai préliminaire de caractérisatin génétique (caryotype et ADN mitochondrial)
Libois, Roland ULg; Torrico, Jorge; Ramalhinho, Maria Graça et al

in Vie et milieu (1996), 46(3-4), 213-218

The colonisation of Europe by the black rat (Rattus rattus) dates back only to the Roman times. This rodent is now widespread all over the continent as well as on many islands where it was introduced by ... [more ▼]

The colonisation of Europe by the black rat (Rattus rattus) dates back only to the Roman times. This rodent is now widespread all over the continent as well as on many islands where it was introduced by man. In some instances, insular populations are morphologically differentiated by their great size. In order to study the possible origin of these insular populations, rats were caught on many Mediterranean (Sicily, Sardinia, Lavezzi, Corsica, Elba, Porquerolles) and Atlantic islands (Ré, Oléron, Azores) and compared to animals from continental Europe (Spain), and Africa (Tunisia, Benin). Their karoytype was determined and their mtDNA restriction patterns studied using the HAEIII and RSA I endonucleases and a polyacrylamide gel electrophoresis. These patterns appear very similar to each other though one of them is specific to the African animals, probably indicating that Europe and Africa were colonised by different strains. [less ▲]

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See detailSeduzione borghese e cultura dell'artificio. Femmes fatales in Oriani e Chelli
Curreri, Luciano ULg

in Italian Quarterly (1996), 129-130

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See detailApproximation of reliability for multiple-trait animal models with missing data by canonical transformation
Gengler, Nicolas ULg; Misztal, I.

in Journal of Dairy Science (1996), 79(2), 317-328

An algorithm for approximation of reliability for multiple traits by multiple diagonalization was modified to support missing data by weighting transformed contributions of records based on the pattern of ... [more ▼]

An algorithm for approximation of reliability for multiple traits by multiple diagonalization was modified to support missing data by weighting transformed contributions of records based on the pattern of missing data. The accuracy of approximation was assessed with simulated and field data by comparing approximate reliabilities with those from direct inversion. Simulated data had several levels of missing data and covariances between traits; correlations were close to those for linear type traits of dairy cattle. Field data were 1) dairy records for milk, fat, and protein yields with 26% of the observations for fat and protein removed and 2) beef records for birth weight, weaning weight, and mean gain after weaning with 43% of observations missing. These files also contained empty fixed effect classes. The algorithm worked best for simulated data, and, when covariances between traits decreased, proportion of missing traits decreased and the number of empty fixed classes decreased. For dairy data, improvement over single-trait reliability occurred only for traits with missing data; for beef data, little or no improvement occurred. The method is useful with multiple diagonalization if the proportion of missing records or number of empty fixed effect classes or covariances between traits is moderate. [less ▲]

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See detailEffect of total treatment time on event-free survival in carcinoma of the cervix
Delaloye, J-F; COUCKE, Philippe ULg; Pampallona, S et al

in Gynecologic Oncology (1996), 60

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See detailLes tempêtes (tempêtes extratropicales, cyclones tropicaux et tornades)
Erpicum, Michel ULg; Van Hoof, Th.

in Le point sur le I de Géographie (Soc géogr de Liège) (1996), 4

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See detailHyperfine structure of Sc I by Infrared Fourier Transform Spectroscopy
Aboussaïd, A.; Carleer, M.; Hurtmans, D. et al

in Physica Scripta (1996), 53

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See detailRelationships of polymorphisms for growth hormone and growth hormone receptor genes with milk production traits for Italian Holstein-Friesian bulls
Falaki, M.; Gengler, Nicolas ULg; Sneyers, M. et al

in Journal of Dairy Science (1996), 79(8), 1446-1453

Allelic variation in the structural or regulatory sequences of growth hormone and its receptor genes might directly or indirectly affect milk traits. This possibility prompted us to investigate the ... [more ▼]

Allelic variation in the structural or regulatory sequences of growth hormone and its receptor genes might directly or indirectly affect milk traits. This possibility prompted us to investigate the eventual relationships of restriction fragment length polymorphisms at the locus of bovine growth hormone (using TagI and MspI restriction enzymes) and its receptor (using TaqI restriction enzyme) production traits of bulls. Holstein-Friesian bulls were used in this experiment, and data were analyzed with a fixed linear model. The restriction fragment length polymorphisms at the growth hormone locus did not affect the milk traits studied. Six restriction enzyme TaqI bands of 7.1, 6.2, 5.7, 5.4, 4.2, and 3.3 kb with nine patterns were observed after hybridization by a cDNA probe containing the coding sequences for the intracellular C-terminal part of the receptor. The effect of this polymorphism on PTA for milk protein percentage was highly significant and was favorable for the rare (6.6%) 5.7- and 5.4-kb pattern. Our results indicate that further study is needed to explain the DNA polymorphism and to obtain more definite conclusions about effects on milk traits. [less ▲]

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See detailFinite element modelling of the competition between shear bands in the early stage of thrusting : Strain localisation and constitutive law influence
Barnichon, Jean-Dominique; Charlier, Robert ULg

in Special Publication - Geological Society of London (1996), 99

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See detailCharacterization of lactogen receptor-binding site 1 of human prolactin
Kinet, Sandrina; Goffin, Vincent; Mainfroid, Véronique et al

in Journal of Biological Chemistry (1996), 271(24), 14353-60

Prolactin (PRL) binds to two molecules of PRL receptor (PRLR) through two regions referred to as binding sites 1 and 2. Although binding site 1 has been generally assigned to the pocket delimited by helix ... [more ▼]

Prolactin (PRL) binds to two molecules of PRL receptor (PRLR) through two regions referred to as binding sites 1 and 2. Although binding site 1 has been generally assigned to the pocket delimited by helix 1, helix 4, and the second half of loop 1, the residues involved in receptor binding have not yet all been precisely identified. In an earlier alanine-scanning mutational study, we identified three major binding determinants in loop 1 of human PRL (hPRL) (Goffin, V., Norman, M. & Martial, J. A.(1992) Mol. Endocrinol. 6, 1381-1392). Here we focus on the two other regions that form binding site 1, namely helices 1 and 4. Putative binding residues, selected on the basis of a three-dimensional model of hPRL constructed in this laboratory, were mutated to alanine, and recombinant hPRL mutants produced in Escherichia coli were tested for their ability to bind to the PRLR and to stimulate Nb2 cell proliferation. We thus identified nine single mutations (three in helix 1 and six in helix 4) whose effect was to reduce both binding and mitogenic activity by more than half as compared with wild-type hPRL, indicating the functional involvement of the corresponding residues. Adding these to the three binding determinants identified in loop 1, we now propose a complete picture of PRLR-binding site 1 of hPRL. As we earlier hypothesized, the binding site 1 determinants of hPRL differ from those of human growth hormone, a hPRL homolog. [less ▲]

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See detailConditional heteroskedasticity adjusted market model and an event study
Corhay, Albert ULg; Tourani-Rad, Alireza

in Quarterly Review of Economics and Finance (1996), 36(4), 529-538

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See detailDensitometric Evaluation of Gentiopicroside in the Roots of Gentiana lutea L.
Bodart, Patricia; Poukens-Renwart, Pascale; Wauters, Jean-Noël ULg et al

in Journal of Planar Chromatography- Modern TLC (1996), 9(March/April), 143-145

As no satisfactory method existed for the separation of gentiopicroside from other components of gentian roots, we have decided to undertake some experiments.In this communication, we report the use of a ... [more ▼]

As no satisfactory method existed for the separation of gentiopicroside from other components of gentian roots, we have decided to undertake some experiments.In this communication, we report the use of a novel mobile phase and a different detection system. Our HPTLC method is a fast and reliable procedure which may be used for quantification of gentiopicroside in roots and extracts of Gentiana lutea, whether for routine analysis or for studying stability. The TLC method is also compared with an HPLC method. [less ▲]

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See detailAntagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay
Goffin, Vincent; Kinet, Sandrina; Ferrag, Fatima et al

in Journal of Biological Chemistry (1996), 271(28), 16573-9

Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced sequential dimerization, potential human PRL (hPRL) antagonists were designed that sterically interfere with binding ... [more ▼]

Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced sequential dimerization, potential human PRL (hPRL) antagonists were designed that sterically interfere with binding site 2. We previously reported the unexpected agonistic properties of these hPRL analogs in the rat Nb2 bioassay (Goffin, V., Struman, I., Mainfroid, V., Kinet, S., and Martial, J. A. (1994) J. Biol. Chem. 269, 32598-32606). In order to investigate whether such paradoxical agonistic behavior might result from characteristic features of the Nb2 assay (e.g. species specificity), we transfected in the same cell system the cDNA encoding the PRLR from rat or human species along with reporter genes containing PRL-responsive DNA sequences. We characterized the agonistic, self-antagonistic and/or antagonistic effects of wild type rat PRL, wild type hPRL, and three hPRL analogs, mutated either at binding site 1 or at binding site 2. Our results clearly show that the agonistic/antagonistic properties of PRLs are species-specific. We thus propose different models of receptor activation, depending on the relative affinities of each hormonal binding site, which is directed by species specificity. Finally, this is the first report of hPRL binding site 2 analogs showing antagonistic properties on human and, to a lesser extent, rat receptors. [less ▲]

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See detailStandardisation des mesures en imagerie thermique infrarouge chez les grands animaux domestiques
Ghafir, Y.; Spruyt, P.; Art, Tatiana ULg et al

in Annales de Médecine Vétérinaire (1996), 140

Thermography studies pictures recorded from radiant thermal emissions of a body. This paper analyses several measurement conditions in order to make thermographic unit reliable, ie the effects of distance ... [more ▼]

Thermography studies pictures recorded from radiant thermal emissions of a body. This paper analyses several measurement conditions in order to make thermographic unit reliable, ie the effects of distance and position of the camera, the color, lenght and power. Moreover, the effects of the site on cutaneous temperature measurements were studied in exercising horses. It can be concluded that infrared thermography is a technical to measure skin temperature which requires a few conditions to be respected. Moreover, it is a sure, simple and fast method. The ideal site for measuring skin temperature inexercising horses is the neck because of its vascularisation. [less ▲]

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See detailIntestinal Digestibility Of Rumen Undegraded N Of Concentrates Measured By The Mobile Nylon Bag Technique
Beckers, Yves ULg; Thewis, André ULg; Maudoux, Benoît

in Animal Feed Science & Technology (1996), 61(1-4), 305-323

Two experiments were carried out on sheep to measure the effects of some factors of the mobile nylon bag (MNB) technique on the intestinal digestibility (DgI) of rumen undegraded N of meat and bone meal ... [more ▼]

Two experiments were carried out on sheep to measure the effects of some factors of the mobile nylon bag (MNB) technique on the intestinal digestibility (DgI) of rumen undegraded N of meat and bone meal (MBM), soybean meal (SBM) and wheat bran (WB). The pore size of the nylon cloth (IO and 42.5 pm) influenced (P < 0.05) DgI of SBM and MBM N irrespective of the site of recovery of the bags (ileum and faeces) and the incubation time of concentrate feeds in the rumen (0, 2, 4, 8, 16 and 24 h). The faecal recovery of the bags increased (P < 0.05) DgI of SBM N in comparison with ileal recovery. The opposite was found with WB incubated 4, 8, 16 and 24 h in the rumen. DgI of MBM N was not influenced by site of bag recovery (P > 0.05). Increasing incubation times in the rumen decreased (P < 0.05) DgI of undegraded feed N. The total tract digestibility (rumen plus intestines) was independent of incubation time in the rumen for MBM and SBM, excepted for SBM incubated 4 or 8 h in the rumen when bags were collected in the ileum. Previous ruminal incubation of WB for 4, 8, 16 and 24 h increased (P < 0.05) the amount of N digested in the total tract in comparison with unincubated WB and WB incubated for only 2 h. In the second experiment, residues obtained from the incubation of the feeds in the rumen (0, 2, 4, 8, 16, 24 and 48 h) were mixed in different proportions in order to obtain the true fraction of the undegraded feed in the rumen. This method was based on the DM degradability of the concentrate feeds and the outflow rate constant of feeds from the rumen, supposed equal to 6%h-‘. Bags containing feeds mixed according to this method were incubated in a solution of pepsin-HCl for 0, 1, 2 and 3 h to simulate abomasal digestion and the DgI of N was measured afterwards with the MNB technique. Increasing action of pepsin led to higher digestibilities of N at this stage (P < 0.05) but decreased the digestibility of N in the intestines excepted for MBM incubated in pepsin-HCl for 3 h and in any case for SBM. However, the omission of the incubation in pepsin had little influence on the amount of N postruminally digested. [less ▲]

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See detailEnrico Mattioda, Teorie della tragedia nel settecento, Modena, Mucchi, 1994, 366
Curreri, Luciano ULg

in Franco-Italica (1996), 9

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See detailThe Potent Angioinhibin Agm-1470 Stimulates Normal but Not Human Tumoral Lymphocytes
Antoine, Nadine ULg; Daukandt, M.; Locigno, R. et al

in Tumori (1996), 82(1, Jan-Feb), 27-30

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects ... [more ▼]

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects have already led to phase I clinical trials in patients with solid cancers. However, neither the exact mechanisms of action of AGM-1470 nor its effects on the host of normal cells have been extensively studied. Recently, we showed that AGM-1470 enhanced the proliferation of B lymphocytes in the presence of T cells. Since AGM-1470 could potentially be used in patients with lymphoma, it was urgent to test the effect of the molecule on the proliferation of tumor lymphocytes. METHODS: The possible effect of AGM-1470 on the proliferation of normal or tumor lymphocytes was evaluated by thymidine-incorporated assays. Normal T and B lymphocytes were purified from human tonsils. The tumor lymphocytes used in the study were Molt 3, Molt 4 and Jurkatt cell lines for the T lineage and Daudi and Radji cell lines for the B lineage. RESULTS: As shown previously, AGM-1470 stimulates the proliferation of normal B lymphocytes through an action on normal T cells. THe angioinhibin was ineffective ont eh proliferation of both T and B transformed cells. Moreover, in the presence of the drug, tumor T cells co-cultured with normal B lymphocytes did not induce any increase in B cell proliferation, as previously observed with normal T lymphocytes. Inversely, tumor B cells co-cultured with normal T lymphocytes were insensitive to the drug. CONCLUSIONS: Our results demonstrate that AGM-1470 is ineffective on lymphoid tumor cell proliferation and could potentially be safely administered to lymphoma patients. [less ▲]

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See detailNéphropathie tubulo-interstitielle aigue avec uvéite: à propos d'un cas
Weber, T.; Beckers, C.; Kaye, O. et al

in Acta Clinica Belgica (1996), 51(1), 53-56

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment ... [more ▼]

We report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment needed to reach the diagnosis. The evolution is unusually favourable with steroid therapy. [less ▲]

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See detailLa réforme du premier degré en Communauté française de Belgique veut relever le défi d'une pédagogie de la réussite
Beckers, Jacqueline ULg

in Recherche en Education. Théorie & Pratique (1996), 5-6

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See detailExpansive benign lesions: treatment by laser.
Smets, Mireille; NISOLLE, Michelle ULg; Bassil, Salim et al

in European Journal of Obstetrics and Gynecology (1996), 65(1), 101-5

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ... [more ▼]

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ablation using the Nd-YAG laser and the advantages of the preoperative use of GnRH agonist therapy. They report their results in a series of 746 patients treated for meno-metrorrhagia (366 cases of myomectomy and 380 cases of endometrial ablation). [less ▲]

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See detailDescription des plantules de quatre Caesalpiniacées africaines
Léonard, J.; Doucet, Jean-Louis ULg

in Bulletin du Jardin Botanique National de Belgique (1996), 66

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See detailFusogenic Properties Of The C-Terminal Domain Of The Alzheimer Beta-Amyloid Peptide
Pillot, T.; Goethals, M.; Vanloo, B. et al

in Journal of Biological Chemistry (1996), 271(46), 28757-65

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was ... [more ▼]

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was investigated. These peptide domains were identified by computer modeling and correspond to respectively the C-terminal (e.g. residues 29-40 and 29-42) and a central domain (13-28) of the beta-amyloid peptide. The C-terminal peptides are predicted to insert in an oblique way into a lipid membrane through their N-terminal end, while the mutants are either parallel or perpendicular to the lipid bilayer. Peptide-induced vesicle fusion was demonstrated by several techniques, including lipid-mixing and core-mixing assays using pyrene-labeled vesicles. The effect of peptide elongation toward the N-terminal end of the entire beta-amyloid peptide was also investigated. Peptides corresponding to residues 22-42 and 12-42 were tested using the same techniques. Both the 29-40 and 29-42 beta-amyloid peptides were able to induce fusion of unilamellar lipid vesicles and calcein leakage, and the amyloid 29-42 peptide was the most potent fusogenic peptide. Neither the two mutants or the 13-28 beta-amyloid peptide had any fusogenic activity. Circular dichroism measurements showed an increase of the alpha-helical content of the two C-terminal peptides at increasing concentrations of trifluoroethanol, which was accompanied by an increase of the fusogenic potential of the peptides. Our data suggest that the alpha-helical content and the angle of insertion of the peptide into a lipid bilayer are critical for the fusogenic activity of the C-terminal domain of the amyloid peptide. The differences observed between the fusogenic capacity of the amyloid 29-40 and 29-42 peptides might result from differences in the degree of penetration of the peptides into the membrane and the resulting membrane destabilization. The longer peptides, residues 22-42 and 12-42, had decreased, but significant, fusogenic properties associated with perturbation of the membrane permeability. These data suggest that the fusogenic properties of the C-terminal domain of the beta-amyloid peptide might contribute to the cytotoxicity of the peptide by destabilizing the cell membrane. [less ▲]

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See detailIncidence of Inflammatory Bowel Disease in the Province of Liege (Belgium). La Societe De Gastroenterologie Liegeoise
Latour, Pascale ULg; Belaiche, Jacques ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (1996), 59(1, Jan-Mar), 3-6

Up to now, as there is no national registry of patients with inflammatory bowel disease (IBD) in Belgium, the study of IBD epidemiology in our country is only possible through institutional or regional ... [more ▼]

Up to now, as there is no national registry of patients with inflammatory bowel disease (IBD) in Belgium, the study of IBD epidemiology in our country is only possible through institutional or regional series. Therefore we conducted a prospective epidemiologic study of IBD in the Province of Liege (1 million inhabitants). METHODS: 29 (out of 47) private and public gastroenterologists completed a standard questionnaire for each patient consulting for the first time with clinical symptoms compatible with IBD between 1/06/1993 and 31/05/1994. RESULTS: During that period 104 cases of IBD were recorded: 56 (54%) Crohn's disease (CD), 36 (35%) ulcerative colitis (UC) including 7 proctitis (19% of UC) and 12 (11%) unclassified colitis. The annual incidence was 5.5 per 100.000 for CD and 3.5 for UC. The sex ratio F/M was 1.7 for CD and 0.7 for UC. The median age at the time of diagnosis was 33.5 yrs for CD and 40 yrs for UC. The highest age specific incidence rate for CD and UC was between 20 and 29 yrs : 13.6 and 6.1, respectively. CONCLUSIONS: This first Belgian prospective study has shown an incidence rate for CD comparable with that seen in north European studies but lower than that seen for UC. These results were similar to those observed in the northern part of France. Belgium appears to be a privileged country to undertake a national register and to study epidemiological aspects of IBD. [less ▲]

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See detailQuantitative measurement of metal ions concentration of proteins separated by electrophoresis
Weber, Georges ULg; Strivay, David ULg; Menendez, M. et al

in International Journal of PIXE (1996), 1-2

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the ... [more ▼]

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the electrophoresis, the gel is dried and each track is scanned with a 2.5 MeV proton beam which triggers metal X-ray fluorescence and then, allows to determine the type of metals contained in an electrophoretic band. For quantitative determination of the amount of the metal contained inside the band, the characteristic X-ray peak area is compared with those obtained with polyacrylamide gels doped with the same metal. The normalization has been achieved by using RBS measurements on the gel itself. The procedure presented seems to be a very useful multielementary method for the metal content analysis and for the determination of the metal amounts inside proteins after their separation by electrophoresis. Furthermore it allows to check if metals remain bound to proteins. [less ▲]

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See detailCardio-respiratory adjustments and arterial blood gases in exercising horses in crisis and in clinical remission
Art, Tatiana ULg; Anciaux, N.; Duvivier, H. et al

in Pferdeheilkunde (1996), 12(4), 717-718

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See detailPerson familiarity and name-retrieval failures: How they are related ?
Brédart, Serge ULg

in Current Psychology of Cognition [=CPC] = Cahiers de Psychologie Cognitive [=CPC] (1996), 15(1), 113-119

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See detailFréquence et importance du charriage dans des rivières à charge de fond graveleuse
Petit, François ULg; Pauquet, A.; Pissart, Albert ULg

in Géomorphologie : Relief, Processus, Environnement (1996)

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See detailHomogeneous Lyapunov Functions and Necessary Conditions for Stabilization
Sepulchre, Rodolphe ULg; Aeyels, D.

in Journal of mathematics for control, signal and systems (1996), 9(1), 34-58

We provide necessary conditions for the stabilization of nonlinear control systems with the additional requirement that a time-invariant homogeneous Lyapunov function exists for the closed-loop system.

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See detailVers une assurance qualité intégrée de la chaîne agro-alimentaire.
Vindevogel, Henri ULg; Daube, Georges ULg; Hans, J. C. et al

in Annales de Médecine Vétérinaire (1996), 140

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See detailEvaluation du rôle préventif des oestroprogestatifs et des thérapeutiques non hormonales dans le cadre de l'ostéoporose postménopausique
Reginster, Jean-Yves ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1996), 25(7), 677-83

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of ... [more ▼]

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of osteoporosis is based on efforts to reach a maximal peak bone mass at the end of the growth period and, subsequently, at the time of menopause. No pharmacological intervention is considered at this stage. Biologically, hormone replacement therapy induces a correction of the biochemical changes observed in markers of bone remodeling at the time of the menopause. A systematic screening of asymptomatic postmenopausal women followed by the induction of hormonal replacement therapy in high risk subjects appears to be an interesting cost/benefit strategy in terms of reasonable attribution of health resources. Nasal administration of calcitonin fully prevents the trabecular bone loss observed during the first years of menopause. Notwithstanding, the exact dose of nasal calcitonin able to prevent bone loss remains to be fully elucidated. Bisphosphonates inhibit bone resorption. Tiludronate prevents trabecular postmenopausal bone loss. The use of selectif estrogen receptor modulators is based on a possible differential action of these molecules, at the level of the estrogenic receptors, depending of the tissue considered. Several direct inhibitors of osteoclastic resorption are also under development. Their main target is either to prevent the linkage of osteoclasts to the bone matrix or to prevent the acidification of bone matrix required to induce the resorption process. [less ▲]

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See detailFactors influencing the behavior of steel columns exposed to fire
Talamona, Didier; Kruppa, Joël; Franssen, Jean-Marc ULg et al

in Journal of Fire Protection Engineering (1996), 8(1), 31-43

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See detailProduction of anti-PMSG antibodies and its relation to the productivity of rabbit does
Lebas, F.; Theau-Clement, M.; Remy, Benoît ULg et al

in World Rabbit Science (1996), 4(2), 57-62

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See detailLa bryoflore d'une mosaïque alluviale rhénane: la réserve naturelle de la Petite Camargue Alsacienne (Haut-Rhin)
Vanderpoorten, Alain ULg; Klein, J. P.; Jaegly, E. et al

in Bulletin de la Société Botanique du Centre-Ouest (1996), 27

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See detailL'endotoxémie dans l'espèce équine. 1ère partie: étiologie et physiopathologie.
Amory, Hélène ULg

in Pratique Vétérinaire Equine (1996), 28

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See detailChanges in nitrogen source modify distribution of excitation energy in the cyanobacterium Phormidium laminosum
deAlda, JAGO; Tapia, M. I.; Franck, Fabrice ULg et al

in Physiologia Plantarum (1996), 97(1), 69-78

In an attempt to clarify the interactions between the available nitrogen source and the photosystems in cyanobacteria, O-2 exchange and fluorescence emission were monitored in spheroplasts and intact ... [more ▼]

In an attempt to clarify the interactions between the available nitrogen source and the photosystems in cyanobacteria, O-2 exchange and fluorescence emission were monitored in spheroplasts and intact cells of the non N-2-fixing cyanobacterium Phormidium laminosum (strain OH-1-p.Cl-1) growing on different nitrogen sources or in the absence of nitrogen. Short-term (time scale of seconds to minutes), NH4+ addition to NO3--growing or N-starved cells and, to a minor extent, NO3- addition to N-starved cells, induced state 2 transitions both in light and dark. Long term (time scale of days), the fluorescence yield of PSI relative to that of PSII at 77 K was higher in NO3-- than in NH4-+ growing cells, and even higher in N-starved cells. In the dark, the plastoquinone pool was more reduced in NH4-+ than in NO3--growing cells. Both PSII and PSI activities and the degree of linking between both photosystems were affected in the long term, so that non-cyclic electron transport decreased in parallel to the ferredoxin requirement to assimilate each nitrogen source. Results indicate that nitrogen metabolism exerts short- and long-term control over the photosynthetic apparatus, which acclimates to the energy requirement of the available nitrogen source. [less ▲]

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See detailLes champs électromagnétiques de faible intensité produisent une vague calcique dans les fibroblastes
Bomans, J.; Lambert, C. A.; Scarpa, B. et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(3-4), 243-9250-2

Human fibroblasts display a Ca2+ wave after irradiation with an electromagnetic field (EMF) of low intensity (100 to 900 microT) as seen by LASER confocal microscopy and excitation of Fluo 3. The number ... [more ▼]

Human fibroblasts display a Ca2+ wave after irradiation with an electromagnetic field (EMF) of low intensity (100 to 900 microT) as seen by LASER confocal microscopy and excitation of Fluo 3. The number of excited cells is proportional to the intensity of EMF between 100 and 900 microT. Cellular activation by a dialysable serum factor is required to induce the Ca2+ wave. It also depends on extracellular Ca2+ and active tyrosine kinases and phospholipase C gamma. [less ▲]

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See detailLa genèse du héros médiocre. Simenon à l'époque Fayard
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (1996), (8), 27-42

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