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See detailA comparison of advanced thermal cycles suitable for upgrading existing power plant
Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Applied Thermal Engineering (1999), 19(3), 227-237

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants ... [more ▼]

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants using fossil fuels. Highly efficient cycles are available : gas turbines combined with waste heat boilers and steam cycles are able to achieve efficiencies above 50-55%. However building new plants requires a large amount of capital. Alternative proposals are based on upgrades of existing plants : capital savings are expected by reusing part of the facilities. In the present study, three parallel proposals are compared on the basis of exergy efficiency; cost of investment and flexibility of operation are also discussed. They are compared with classical Rankine cycle and state of the art combined cycles. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailReport of the Sixth International Workshop on Human Chromosome 11 Mapping 1998. Nice, France, May 2-5, 1998.
Gaudray, P.; Carle, G. F.; Gerhard, D. S. et al

in CytoGenetics & Cell Genetics (1999), 86(3-4), 167-86

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See detailPrognostic Factors in Urothelial Renal Pelvis and Ureter Tumours: a Multicentre Rare Cancer Network Study
Ozsahin, M; Zouhair, A; Villa, S et al

in European Journal of Cancer & Clinical Oncology (1999), 35/5

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter ... [more ▼]

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n=71), nephroureterectomy and lymphadenectomy (n=20), nephroureterectomy and partial bladder resection or transurethral resection (n=20), nephrectomy (n=10), and ureterectomy (n=5). Sixty-one per cent (n=77) of the tumours were located in the renal pelvis, and 21% (n=27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis. [less ▲]

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See detailEndometrial laser intrauterine thermo-therapy (ELITT™): a revolutionary new approach to the elimination of menorrhagia
Donnez, Jacques; Polet, Roland; Squifflet, Jean et al

in Current Opinion in Obstetrics & Gynecology (1999), 11(4), 363-70

Various non-hysteroscopic procedures have been developed in the attempt to treat dysfunctional uterine bleeding that fails to respond to medical treatment efficiently and easily. Among these procedures is ... [more ▼]

Various non-hysteroscopic procedures have been developed in the attempt to treat dysfunctional uterine bleeding that fails to respond to medical treatment efficiently and easily. Among these procedures is low-dose laser radiation of the endometrium with the diode source, which is characterized by the highest incidence of amenorrhea. [less ▲]

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See detailLes aliments industriels chez les carnivores domestiques : III. L'alimentation des chiens de grande race en croissance.
Derua, N.; Istasse, Louis ULg; Diez, Marianne ULg

in Annales de Médecine Vétérinaire (1999), 143

Actually the number of pet foods for growing dogs is increasing, so that the choice is becoming more and more difficult. The specific feeding of puppies of large and giant breeds is documented in many ... [more ▼]

Actually the number of pet foods for growing dogs is increasing, so that the choice is becoming more and more difficult. The specific feeding of puppies of large and giant breeds is documented in many studies. The aim of the present paper is to summarise the main studies related to skeletal disorders in the growing dog in order to avoid feeding errors by the practitioner. The requirements of the growing dogs are reviewed along with the development of the main orthopaedic diseases. Then the nutrients to be taken into consideration in the feeding of the growing dogs are discussed. Finally a comparison between different pet foods for growing dog shows a largely variable composition. Practical applications are made to compare the nutrient supplies from different foods to dogs of medium and large breeds. [less ▲]

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See detailVaccinia virus intracellular mature virions contain only one lipid membrane
Hollinshead, M.; Vanderplasschen, Alain ULg; Smith, G. L. et al

in Journal of Virology (1999), 73

Vaccinia virus (VV) morphogenesis commences with the formation of lipid crescents that grow into spherical immature virus (IV) and then infectious intracellular mature virus (IMV) particles. Early studies ... [more ▼]

Vaccinia virus (VV) morphogenesis commences with the formation of lipid crescents that grow into spherical immature virus (IV) and then infectious intracellular mature virus (IMV) particles. Early studies proposed that the lipid crescents were synthesized de novo and matured into IMV particles that contained a single lipid bilayer (S. Dales and E. H. Mosbach, Virology 35:564-583, 1968), but a more recent study reported that the lipid crescent was derived from membranes of the intermediate compartment (IC) and contained a double lipid bilayer (B. Sodiek et al., J. Cell Biol. 121:521-541, 1993). In the present study, we used high-resolution electron microscopy to reinvestigate the structures of the lipid crescents, IV, and IMV particles in order to determine if they contain one or two membranes. Examination of thin sections of Epon-embedded, VV-infected cells by use of a high-angular-tilt series of single sections, serial-section analysis, and high-resolution digital-image analysis detected only a single, 5-nm-thick lipid bilayer in virus crescents, IV, and IMV particles that is covered by a 8-nm-thick protein coat. In contrast, it was possible to discern tightly apposed cellular membranes, each 5 nm thick, in junctions between cells and in the myelin sheath of Schwann cells around neurons. Serial-section analysis and angular tilt analysis of sections detected no continuity between virus lipid crescents or IV particles and cellular membrane cisternae. Moreover, crescents were found to form at sites remote from IC membranesnamely, within the center of virus factories and within the nucleusdemonstrating that crescent formation can occur independently of IC membranes. These data leave unexplained the mechanism of single-membrane formation, but they have important implications with regard to the mechanism of entry of IMV and extracellular enveloped virus into cells; topologically, a one-to-one membrane fusion suffices for delivery of the IMV core into the cytoplasm. Consistent with this, we have demonstrated previously by confocal microscopy that uncoated virus cores within the cytoplasm lack the IMV surface protein D8L, and we show here that intracellular cores lack the surface protein coat and lipid membrane. [less ▲]

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See detailNumerical simulation of crashworthiness with an implicit finite element code
Graillet, Denis; Ponthot, Jean-Philippe ULg

in Aircraft Engineering & Aerospace Technology (1999), 71(1), 12-20

Implicit and explicit time integration schemes in conjunction with the finite element method are presented for the transient response of highly non-linear problems such as impact situations exhibiting ... [more ▼]

Implicit and explicit time integration schemes in conjunction with the finite element method are presented for the transient response of highly non-linear problems such as impact situations exhibiting important material dissipation. Surprisingly the implicit schemes lead to excellent convergence properties that make them a cost-efficient alternative to explicit scheme generally advocated as the best choice for these problems. As numerical illustrations, we present here the academic impact between two flexible bodies, a long tube and a long plate, as well as a more industrial-oriented application: the impact between a fan blade and a double casing. [less ▲]

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See detailIntérêt de la tomographie à émission de positons dans l'évaluation des tumeurs gastro-intestinales
Rigo, Pierre ULg; Albérini, Jean-Louis; Hustinx, Roland ULg et al

in Acta Endoscopica (1999), 29(2), 129-138

La TEP au 18FDG présente de nombreuses indications dans l'évaluation des tumeurs digestives. Son rôle principal concerne le bilan d'extension des récidives tumorales démontrées ou suspectées mais des ... [more ▼]

La TEP au 18FDG présente de nombreuses indications dans l'évaluation des tumeurs digestives. Son rôle principal concerne le bilan d'extension des récidives tumorales démontrées ou suspectées mais des indications plus ponctuelles concernent évalement le diagnostic différentiel des masses pancréatiques et le bilan du cancer de l'oesophage. Le principal avantage de la TEP résulte de la nature métabolique du signal indépendant et complémentaire des modifications anatomiques visibles en imagerie classique. Un autre avantage est lié à l'examen du corps entier aujourd'hui pratiqué systématiquement. La TEP trouve dès lors sa place en première ligne dans ses différentes indications. [less ▲]

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See detailLicéité des baux au regard de la police de l'aménagement du territoire et de l'urbanisme
Delnoy, Michel ULg

in Actualités Juridiques des Baux (1999)

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See detailAirway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling
Legrand, C.; Gilles, Christine ULg; Zahm, J. M. et al

in Journal of Cell Biology (1999), 146(2), 517-29

Cell spreading and migration associated with the expression of the 92-kD gelatinase (matrix metalloproteinase 9 or MMP-9) are important mechanisms involved in the repair of the respiratory epithelium. We ... [more ▼]

Cell spreading and migration associated with the expression of the 92-kD gelatinase (matrix metalloproteinase 9 or MMP-9) are important mechanisms involved in the repair of the respiratory epithelium. We investigated the location of MMP-9 and its potential role in migrating human bronchial epithelial cells (HBEC). In vivo and in vitro, MMP-9 accumulated in migrating HBEC located at the leading edge of a wound and MMP-9 expression paralleled cell migration speed. MMP-9 accumulated through an actin-dependent pathway in the advancing lamellipodia of migrating cells and was subsequently found active in the extracellular matrix (ECM). Lamellipodia became anchored through primordial contacts established with type IV collagen. MMP-9 became amassed behind collagen IV where there were fewer cell-ECM contacts. Both collagen IV and MMP-9 were involved in cell migration because when cell-collagen IV interaction was blocked, cells spread slightly but did not migrate; and when MMP-9 activation was prevented, cells remained fixed on primordial contacts and did not advance at all. These observations suggest that MMP-9 controls the migration of repairing HBEC by remodeling the provisional ECM implicated in primordial contacts. [less ▲]

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See detailNanometer scale organization of mixed surfactin/phosphatidylcholine monolayers
Deleu, Magali ULg; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Biophysical Journal (1999), 77(4), 2304-2310

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic ... [more ▼]

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). AFM topographic images revealed phase separation for mixed monolayers prepared at 0.1, 0.25, and 0.5 surfactin molar ratios. This was in agreement with the monolayer properties at the air-water interface indicating a tendency of the two compounds to form bidimensional domains in the mixed systems. The step height measured between the surfactin and the DPPC domains was 1.2 +/- 0.1 nm, pointing to a difference in molecular orientation: while DPPC had a vertical orientation, the large peptide ring of surfactin was lying on the mica surface. The N/C atom concentration ratios obtained by XPS for pure monolayers were compatible with two distinct geometric models: a random layer for surfactin and for DPPC, a layer of vertically-oriented molecules in which the polar headgroups are in contact with mica. XPS data for mixed systems were accounted for by a combination of the two pure monolayers, considering respective surface coverages that were in excellent agreement with those measured by AFM. These results illustrate the complementarity of AFM and XPS to directly probe the molecular organization of multicomponent monolayers. [less ▲]

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See detailDecreased Corticosensitivity in Quiescent Crohn's Disease: An Ex Vivo Study Using Whole Blood Cell Cultures
Franchimont, Denis; Louis, Edouard ULg; Dupont, Pierre et al

in Digestive Diseases & Sciences (1999), 44(6), 1208-15

Corticosensitivity influences the degree and the duration of an inflammatory reaction by altering target cell responses to endogenous and/or exogenous glucocorticoids. Indeed, different clinical responses ... [more ▼]

Corticosensitivity influences the degree and the duration of an inflammatory reaction by altering target cell responses to endogenous and/or exogenous glucocorticoids. Indeed, different clinical responses to glucocorticoids have been observed among patients with Crohn's disease, suggesting different degrees of corticosensitivity in these subjects. The purpose of this study was to compare the corticosensitivity of patients with quiescent Crohn's disease to that of healthy subjects (HS). Nineteen patients with quiescent Crohn's disease and 14 HS were studied; all patients were steroid-free for at least six months; 7 of the 19 were corticosteroid-dependent (CSD) and treated with nonglucocorticoid immunosuppressants at the time of the study. Corticosensitivity was measured by the inhibition of LPS-induced cytokine secretion in whole blood cell cultures treated with increasing concentrations (10(-9) to 10(-6) M) of dexamethasone. Tumor-necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) were measured using specific immunoassays. Crohn's disease patients had a markedly decreased dexamethasone-mediated inhibition of TNF-alpha (P < 0.01), IL-6 (P < 0.001), and IL-1 beta (P < 0.01) compared to healthy subjects, with a shift of the dexamethasone dose-response curve to the right. No significant differences in the basal and LPS-stimulated secretion of the three cytokines were observed between CSD and non-CSD patients, and both subgroups of patients had similar degrees of dexamethasone-mediated cytokine inhibition. We conclude that patients with Crohn's disease have a significant decrease in the corticosensitivity of their leukocytes. This may be related to a specific genetic/constitutional background and/or could be acquired, due to inflammation-related endocrine and/or immune factors. [less ▲]

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See detailUltrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon in horses.
Denoix, J. M.; Busoni, Valeria ULg

in Equine Veterinary Journal (1999), 31(3), 186-91

The ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon (AL-SDFT) in the horse is presented. Comparison between anatomical sections of isolated limbs and ultrasound ... [more ▼]

The ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon (AL-SDFT) in the horse is presented. Comparison between anatomical sections of isolated limbs and ultrasound scans of the distal antebrachium in sound horses enabled the authors to establish the normal reference ultrasonographic images of this structure. The AL-SDFT inserts 7-14 cm above the antebrachiocarpal joint on the palmaromedial aspect of the radius. Ultrasonographically it appears as an uniformly echogenic structure located deep to the median artery. The knowledge of ultrasonographic anatomy is essential for identification of abnormal images and assessment of AL-SDFT damage. [less ▲]

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See detailIntroduction
Martiniello, Marco ULg; Statham, Paul

in Journal of Ethnic & Migration Studies (1999), 25(4), 565-573

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See detailEnquête sur le "pouvoir thérapeutique" des dauphins
Servais, Véronique ULg

in Recherches en Communication (1999), 12

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest ... [more ▼]

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest that the "therapeutic effect" of animals are very sensitive to the experimental setting designed to demonstrate them. They tend to disappear in very stricly controlled conditions. The study also shows that the hypothesis that talk about "therapeutic effect" of animals are formally analogous to the magical talks about dolphin's "power to heal". [less ▲]

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See detailLe sémioticien
Durand, Pascal ULg

in Art&Fact (1999), (18), 81-82

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See detailNovel macromolecular architectures based on aliphatic polyesters: relevance of the "coordination-insertion" ring-opening polymerization
Mecerreyes, David; Jérôme, Robert ULg; Dubois, Philippe ULg

in Advances in Polymer Science (1999), 147

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e ... [more ▼]

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e., lactones, lactides, glycolide, is introduced. An insight into this so-called "coordination-insertion" mechanism and the ability of this living polymerization process to prepare well-defined homopolymers, telechelic polymers, random and block copolymers is then discussed. In the second part, the combination of the living ROP of (di)lac-tones with other well-controlled polymerization mechanisms such as anionic, cationic, free radical, and metathesis polyadditions of unsaturated comonomers, as well as polyconden-sations, is reported with special emphasis on the design of new and well-tailored macromolecular architectures. As a result of the above synthetic breakthrough, a variety of novel materials have been developed with versatile applications in very different fields such as biomedical and microelectronics. [less ▲]

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See detailAutomated Sample Preparation Techniques for the Determination of Drug Enantiomers in Biological Fluids Using Liquid Chromatography with Chiral Stationary Phases
Ceccato, Attilio ULg; Toussaint, B.; Chiap, Patrice ULg et al

in Enantiomer (1999), 4(3-4), 305-15

The determination of drug enantiomers has become of prime importance in the field of pharmaceutical and biomedical analysis. Liquid chromatography (LC) is one of the most frequently used techniques for ... [more ▼]

The determination of drug enantiomers has become of prime importance in the field of pharmaceutical and biomedical analysis. Liquid chromatography (LC) is one of the most frequently used techniques for achieving the separation and quantitation of the enantiomers of drug compounds. In the bioanalytical field, the integrated systems present an interesting alternative to time-consuming sample preparation techniques such as liquid-liquid extraction. Solid phase extraction (SPE) on disposable cartridges, dialysis or column switching are sample preparation techniques that can be fully automated and applied to enantioselective analysis in biological fluids. The selection of the most appropriate LC mode and chiral stationary phase for enantioseparations in bioanalysis is discussed and some aspects of these automated sample preparation procedures are compared, such as selectivity, detectability, elution of the analytes from the extraction sorbent, sample volume and analyte stability. [less ▲]

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See detail- Evolution of lipoxygenase activity during storage of potato tubers (Solanum tuberosum L. cv. Bintje)
Fauconnier, Marie-Laure ULg; Koto, N.; Hoyaux, P. et al

in Bulletin de la Société des Sciences de Liège (1999), 68(5-6), 319

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See detailEarly prepubertal ontogeny of pulsatile gonadotropin-releasing hormone (GnRH) secretion: I. Inhibitory autofeedback control through prolyl endopeptidase degradation of GnRH.
Yamanaka, C.; LEBRETHON, Marie-Christine ULg; Vandersmissen, E. et al

in Endocrinology (1999), 140(10), 4609-15

GnRH[1-5], a subproduct resulting from degradation of GnRH by prolyl endopeptidase (PEP) and endopeptidase 24.15 (EP24.15) was known to account for an inhibitory autofeedback of GnRH secretion through an ... [more ▼]

GnRH[1-5], a subproduct resulting from degradation of GnRH by prolyl endopeptidase (PEP) and endopeptidase 24.15 (EP24.15) was known to account for an inhibitory autofeedback of GnRH secretion through an effect at the N-methyl-D-aspartate (NMDA) receptors. This study aimed at determining the possible role of such a mechanism in the early developmental changes in frequency of pulsatile GnRH secretion. Using retrochiasmatic explants from fetal male rats (day 20-21 of gestation), no GnRH pulses could be observed in vitro, whereas pulses occurred at a mean interval of 86 min from the day of birth onwards. This interval decreased steadily until day 25 (39 min), during the period preceding the onset of puberty. Based on GnRH[1-10] or GnRH[1-9] degradation and GnRH[1-5] generation after incubation with hypothalamic extracts, EP24.15 activity did not change with age, whereas PEP activity was maximal at days 5-10 and decreased subsequently until day 50. These changes were consistent with the ontogenetic variations in PEP messenger RNAs (mRNAs) quantitated using RT-PCR. Using fetal explants, the NMDA-evoked release of GnRH was potentiated in a dose-dependent manner by bacitracin, a competitive PEP inhibitor and the desensitization to the NMDA effect was prevented using 2 mM of bacitracin. At day 5, a higher bacitracin concentration of 20 mM was required for a similar effect. Pulsatile GnRH secretion from fetal explants was not caused to occur using bacitracin or Fmoc-Prolyl-Pyrrolidine-2-nitrile (Fmoc-Pro-PyrrCN), a noncompetitive PEP inhibitor. At postnatal days 5 and 15, a significant acceleration of pulsatility was obtained using 1 microM of Fmoc-Pro-PyrrCN or 2 mM of bacitracin. At 25 and 50 days, a lower bacitracin concentration of 20 microM was effective as well in increasing the frequency of GnRH pulsatility. We conclude that the GnRH inhibitory autofeedback resulting from degradation of the peptide is operational in the fetal hypothalamus but does not explain the absence of pulsatile GnRH secretion at that early age. After birth, PEP activity is high and may account for the low frequency of pulsatility. The potency of that effect decreases before the onset of puberty and may contribute to the acceleration of GnRH pulsatility. [less ▲]

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See detailLes Caecilii, la Sicile et le judaïsme
Rochette, Bruno ULg

in Maia (1999), 51

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See detailThe Structural And Functional Organization Of H-Ns-Like Proteins Is Evolutionarily Conserved In Gram-Negative Bacteria
Bertin, P.; Benhabiles, N.; Krin, E. et al

in Molecular Microbiology (1999), 31(1), 319-29

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi ... [more ▼]

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi and Haemophilus influenzae. Isolated outside these groups, the BpH3 protein of Bordetella pertussis exhibits a low amino acid conservation with H-NS, particularly in the N-terminal domain. To obtain information on the structure, function and/or evolution of H-NS, we searched for other H-NS-related proteins in the latest databases. We found that HvrA, a trans-activator protein in Rhodobacter capsulatus, has a low but significant similarity with H-NS and H-NS-like proteins. This Gram-negative bacterium is phylogenetically distant from Escherichia coli. Using theoretical analysis (e.g. secondary structure prediction and DNA binding domain modelling) of the amino acid sequence of H-NS, StpA (an H-NS-like protein in E. coli), BpH3 and HvrA and by in vivo and in vitro experiments (e.g. complementation of various H-NS-related phenotypes and competitive gel shift assay), we present evidence that these proteins belong to the same class of DNA binding proteins. In silico analysis suggests that this family also includes SPB in R. sphaeroides, XrvA in Xanthomonas oryzae and VicH in Vibrio cholerae. These results demonstrate that proteins structurally and functionally related to H-NS are widespread in Gram-negative bacteria. [less ▲]

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See detailWomen’s Work in Rural China, Change and Continuity in an Era of Reform.
Florence, Eric ULg

in China Information (1999), Volume XIV(Summer/Spring 1999), 137-138

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See detailPretransplant helper T-lymphocyte determination in bone marrow donors: acute graft-versus-host disease prediction and relation with long-term survival
Winandy, Marie ULg; Lewalle, Philippe; Deneys, Véronique et al

in British Journal of Haematology (1999), 105

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency ... [more ▼]

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency was estimated in limiting dilution cultures, and HLA-DR and CD 80 expression by stimulating cells was measured by flow cytometry. 12/19 patients experienced acute graft-versus-host disease (aGVHD) grade II–IV. A good correlation was found between high pretransplant HTLp frequency and grade II–IV aGVHD (median: 1/55848 PBMNC for II–IV GVHD versus 1/ 184346 for 0–I GVHD; P¼0·008). Sensitivity was 82%, specificity 63%, negative predictive value 71% and positive predictive value 75%. Long-term survivors also had a lower HTLp median frequency (1/143354) when compared with patients who died as a result of the transplant procedure (1/22100, P < 0·001). No correlation was found between HTLp frequency and HLA-DR or CD80 expression by patient’s cells. We conclude that HTLp frequency estimation can predict, although poorly, acute GVHD risk and long-term survival. [less ▲]

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See detailGenes for rare idiopathic generalized epilepsies: BFNC.
Singh, N.; Charlier, Carole ULg; Peiffer, A. et al

in Advances in neurology (1999), 79

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See detailRadiative Properties of Neutral Germanium obtained from excited-state lifetime and branching-ratio measurements and comparison with theoretial calculations
Li, Z. S.; Norin, J.; Persson, A. et al

in Physical Review. A (1999), 60

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See detailGerhard Herzberg (1904-1999)
Biémont, Emile ULg; Dubois, I.

in Annuaire Cl. Sc. Acad. Roy. (1999), X

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See detailCAPPP trial. Captopril Prevention Project.
Scheen, André ULg

in Lancet (1999), 353(9166), 1793-41795-6

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See detailHigh Prevalence of Low Femoral Bone Mineral Density in Elderly Women Living in Nursing Homes or Community-Dwelling: A Plausible Role of Increased Parathyroid Hormone Secretion
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Pirenne, H. et al

in Osteoporosis International (1999), 9(2), 121-8

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH ... [more ▼]

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH vitamin D (25-OHD) with those of subjects living at home, in the immediate vicinity of the nursing homes. Of 1483 women, aged 70 years and older, who were selected, 993 agreed to participate in this trial. Their femoral neck BMD (n = 993) was measured by dual-energy X-ray absorptiometry, with a specific device installed in a mobile truck. The circulating levels of 25-OHD and PTH were assessed after an overnight fast (n = 748). After stratification for age, there were no significant differences in mean femoral neck BMD values, prevalence of femoral neck osteoporosis, mean serum 25-OHD and prevalence of absolute or relative 25-OHD deficiency between the two groups. Serum levels of PTH were significantly higher in women over 80 years old living in nursing homes, compared with the community-dwelling women. After adjustment for age, a significant relation was found between femoral neck BMD and PTH levels in the whole population (p = 0.004) and in community-dwelling subjects (p = 0.039). When stratifying our population by quartiles of serum PTH values, the odds ratios for femoral neck osteoporosis were significantly increased for the top two quartiles compared with the lowest one both before (p = 0.00146) and after (p = 0.0013) adjustment for age and type of housing. From this study we conclude that femoral osteoporosis is largely underestimated in European women. Living in a nursing home is not, per se, a risk factor for decreased femoral BMD, and circulating PTH levels are a key determinant of low femoral bone density and osteoporosis. [less ▲]

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See detailPaolo Rossi, Le Philosophe et les Machines (1400-1700)
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 38(printemps), 127-128

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See detailQuantitative palynology of Famennian events in the Ardenne-Rhine Regions.
Streel, Maurice ULg

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailSynthesis and pharmacological evaluation of KATP-channel openers related to cromakalim: introduction of arylsulphonylurea moieties
Khelili, S.; Nguyen, Q.-A.; Lebrun, P. et al

in Pharmacy and Pharmacology Communications (1999), 5

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See detailLocal order of the high-pressure metallic phase of liquid selenium: a diffraction study
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Le Bihan, T. et al

in Journal of Physics : Condensed Matter (1999), 11(50), 10243-1024910249

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength ... [more ▼]

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength of 0.149 Aring to investigate the local order of the metallic liquid. The diffraction pattern of liquid Se has been recorded with the large-volume Paris-Edinburgh cell between (20degC, 3 GPa) and (1650degC, 4.1 GPa). The local order of the metallic liquid selenium is found to be close to that of liquid tellurium. In particular, the coordination number Z increases with temperature from 2.6 to 3.0 [less ▲]

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See detailLe traitement des ectasies anevrysmales de l'aorte ascendante par l'intervention de Robicsek
RADERMECKER, Marc ULg; Laurent, S.; Limet, Raymond ULg

in Revue Médicale de Liège (1999), 54(11), 886-8

The technique and the results of the external contention of the dilated ascending aorta by the application of an external Dacron graft are reported. This technique, without replacing the usual graft ... [more ▼]

The technique and the results of the external contention of the dilated ascending aorta by the application of an external Dacron graft are reported. This technique, without replacing the usual graft interposition, can efficiently and expeditiously treat borderline dilatation of the ascending aorta, as frequently encountered in aortic valve disease. If the sinotubular junction is not dilated, this technique may stop the aneurysmal evolution of the ascending aorta. [less ▲]

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See detailZoos, éducation et malentendus: Essai d'anthropologie des émotion du visiteur de zoo
Servais, Véronique ULg

in Cahiers d'Ethologie (1999), 19(1), 1-16

In the current debate about the zoo's educational role it s usually assumed that the emotional aspect of the zoo experience impairs the scienfic knowledge that people can gain from their visit. First we ... [more ▼]

In the current debate about the zoo's educational role it s usually assumed that the emotional aspect of the zoo experience impairs the scienfic knowledge that people can gain from their visit. First we briefly describe four human-animal interactionnal patterns that can be observed in a zoo, and we recognise that indeed, in that context, the emotion experienced by the public impairs its knowledge of the animals. then we persent the Hediger's distinctin between an object and a subject animal and we hypothesise that the visitor's emotions impari animal knowledge only when the exhibited animals are object-animals. Those are incomplete animals : they are not complete beings in relation to their evolutionary environment. It is our view that when the exhibited animals are more complete organisms, the emotions can be a tool for a better knowledge of the animals. [less ▲]

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See detailLes transferts post-mortem : réinterprétation symbolique du lieu d’enterrement dans un contexte de mobilité des populations
Schmitz, Serge ULg

in Espaces et Sociétés (Paris, France) (1999), 99

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery ... [more ▼]

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery choice. It underlines the connections between post-mortem mobility, the different levels of population mobility and culture. [less ▲]

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See detailMarie Harris's Weasel in the Turkey Pen
Delville, Michel ULg

in The Prose Poem : an International Journal (1999), 8

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See detailImplication des propriétés biomécaniques des muscles transformés dans le mécanisme de la cardiomyoplastie
Radermacker, M. A.; Sluse, Francis ULg; Focant, B. et al

in Journal of Cardiology (1999), 9

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See detailStudy of the mechanism of direct laser desorption/ionisation for some small organic molecules (M < 400 daltons)
Benazouz, M.; Hakim, B.; Debrun, J. L. et al

in Rapid Communications in Mass Spectrometry : RCM (1999), 13(23), 2302-2304

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates ... [more ▼]

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates, and a nitrogen laser is used for desorption/ionisation; ion yields are measured with a time-of-flight mass spectrometer, Previous work had shown that ion yields can strongly vary from one substrate to another, and that this variation does not reflect the (calculated) metal surface temperatures. New results obtained in this work indicate that the desorption/ionisation mechanism is linked to the physical state of the substrate surface. Copyright (C) 1999 John Wiley & Sons, Ltd. [less ▲]

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See detailLa prescription de l'action délictuelle en droit du travail après la loi du 10 juin 1998
Kefer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (1999)

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See detail"Destinataire final" des subsides cherche privilège, note sous Bruxelles, 1e octobre 1997
Lissoir, Bénédicte ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailComparaison des Kess-Kess de Hmar Lakhdad (Emsien, Maroc) et des monticules micritiques de l'anticlinorium de Philippeville (Frasnien, Belgique)
Hilali, A.; Lachkem, H.; Boulvain, Frédéric ULg

in Geologica Belgica (1999), 1

A Comparison between the Kess-kess of Hmar Lakhdad (Emsian, Morocco) and the mud mounds of the Philippeville Anticlinorium (Frasnian, Belgium). The Kess-kess of Hmar Lakhdad are Devonian mud mounds ... [more ▼]

A Comparison between the Kess-kess of Hmar Lakhdad (Emsian, Morocco) and the mud mounds of the Philippeville Anticlinorium (Frasnian, Belgium). The Kess-kess of Hmar Lakhdad are Devonian mud mounds, located SE of Erfoud (Moroccan Antiatlas). Fenestral structures, which are very abundant, occur from the base to the top of most buildups. These structures are classified in two groups: stromatactis s.s. and stromatactoid fenestrae. each of them showing a high morphological variability. These fenestrae look very similar to the structures already described from the Belgian mud mounds. However, their attribution to sponges cannot be demonstrated. Microstromatolifhes, a microbial structure, are common in the Moroccan and Belgian buildups. The numerous sedi-mentological similarities between the two types of mounds allow to assign the facies of the Kess-kess to the coral-crinoidal limestones at the base of the Belgian buildups. This comparison justifies a paleoecological and paleobathy-metrical interpretation of the Moroccan mud mounds. [less ▲]

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See detail7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg

in Acta Crystallographica (1999), C55

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See detailStudy of the impact of a gastroplasty on the self-image through the Rorschach
Marsden, Eric; Michel, Aude; Mormont, Christian ULg

in Rorschachiana (1999), 23

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See detailStructure of high temperature fluid selenium
Bichara, C.; Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg

in Journal of Non-Crystalline Solids (1999), 250-252

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures ... [more ▼]

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures obtained are in agreement with the X-ray scattering and extended X-ray absorption fine structure (EXAFS) data in a range of temperatures and densities. A correlation between the conductivity of high temperature fluid selenium and the degree of branching and breaking of the selenium chains is observed [less ▲]

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See detailAnalysis of fluorescence lifetime of protochlorophyllide and chlorophyllide in isolated etioplast membranes measured from multifrequency cross-correlation phase fluorometry
Mysliwa-Kurdziel, B.; Franck, Fabrice ULg; Strzalka, K.

in Photochemistry & Photobiology (1999), 70(4), 616-623

The fluorescence decays of protochlorophyllide (Pchlide) and of chlorophyllide (Chlide) in wheat etioplast membranes were analyzed using a multiexponential fluorescence decay model. Using different ... [more ▼]

The fluorescence decays of protochlorophyllide (Pchlide) and of chlorophyllide (Chlide) in wheat etioplast membranes were analyzed using a multiexponential fluorescence decay model. Using different excitation wavelengths from 430 to 470 nm, we found that a triple-exponential model at 14 degrees C and a double-exponential model at -170 degrees C were adequate to describe the Pchlide fluorescence decay. We discuss the origin of the three fluorescence lifetime components at 14 degrees C on the basis of the dependence of their fractional intensities on the excitation wavelength and by correlating the fractional intensities with integrated fluorescence intensities of different Pchlide forms in steady-state fluorescence spectra, The fluorescence decay of the main Pchlide form, photoactive Pchlide-F657, is shown to have a complex character with a fast component of 0.25 ns and a slower component of about 2 ns. Two lifetime components of 2 ns and 5.5-6.0 ns are ascribed to the second photoactive form, Pchlide-F645, and to nonphotoactive Pchlide forms, respectively. In etioplast membranes preilluminated by a short saturating fight pulse, we found a single 5.0 ns component for Chlide-F688 (the Chlide-NADPH :protochlorophyllide oxidoreductase [POR]-NADP(+) complex) and an additional 1.6 ns component when the formation of Chlide-F696 (the Chlide-POR-NADPH complex) was promoted by exogenous NADPH, From the fluorescence lifetime results we evaluated the quantum yield of the primary photoreaction by Chlide-F696 as being 70%. [less ▲]

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See detailAlveolar clearance in horses with chronic obstructive pulmonary disease
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, D. H. et al

in American Journal of Veterinary Research (1999), 60

OBJECTIVE: To assess sensitivity of scintigraphic alveolar clearance rate as an indicator of alveolar epithelium damage in horses. ANIMALS: 5 healthy horses (group A) and 5 with chronic obstructive ... [more ▼]

OBJECTIVE: To assess sensitivity of scintigraphic alveolar clearance rate as an indicator of alveolar epithelium damage in horses. ANIMALS: 5 healthy horses (group A) and 5 with chronic obstructive pulmonary disease (COPD; group B). PROCEDURE: Horses underwent clearance rate (k [%/min]) determination. Clearance rate of group-B horses was determined after remission of the disease following 2 months at pasture (remission 1), stabling in a controlled environment (remission 2), and during crisis induced by exposure to moldy hay and straw. Methacholine challenge test was performed at each investigation period to determine nonspecific pulmonary airway hyperresponsiveness. Pulmonary function tests (PFT) also were performed, and cell populations in bronchoalveolar lavage (BAL) fluid were determined on another occasion. RESULTS: Group-B horses had significantly faster mean clearance rate during crisis (k = 4.30+/-0.95%/min), compared with that for remission 1(k = 1.98+/-0.55%/min), which did not differ from the rate in group-A horses (k = 1.95+/-0.33%/min). Despite lack of clinical signs of COPD during remission when stabled in a controlled environment, an intermediate value was found (k = 3.20+/-0.72%/min). CONCLUSIONS: This technique allowed grading of lung damage induced by COPD, whereas use of PFT and determination of BAL fluid cell populations failed to differentiate between remission 1 and remission 2. CLINICAL RELEVANCE: Determination of alveolar clearance rate by use of scintigraphy is a sensitive indicator of lung damage. A modified clearance rate was found despite the lack of clinical and functional changes [less ▲]

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See detailEletriptan: a viewpoint
Schoenen, Jean ULg

in CNS Drugs (1999), 12(4), 334-335

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See detailImmunocytochemistry of lipids : chemical fixatives have dramatic effects on the preservation of tissue lipids
Maneta-Peyret, Lilly; Compère, Philippe ULg; Moreau, Patrick et al

in Histochemical Journal (The) (1999), 31

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See detailFinancement des cultes et Impôt Philosophiquement Dédicacé : éléments budgétaires et aspects pratiques
Husson, Jean-François ULg

in Revue Politique (La) (1999), (4-5), 47-87

This article reviews the channels and amounts of public financing for religious and philosophical communities in Belgium and confronts them with possibile alternatives, most notably the "impot ... [more ▼]

This article reviews the channels and amounts of public financing for religious and philosophical communities in Belgium and confronts them with possibile alternatives, most notably the "impot philosophiquement dedicacé" (or the affectation of a percentage of the income tax). [less ▲]

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See detailPregnancy Associated Glycoproteins in Ruminants: Inactive Members of the Aspartic Proteinase Family
Beckers, Jean-François ULg; Drion, Pierre ULg; Garbayo, J. M. et al

in Acta Veterinaria Hungarica (1999), 47(4), 461-9

The Pregnancy Associated Glycoproteins (PAGs) presented in this paper are largely expressed in the ruminant placenta. These proteins are classified as probably inactive members of the aspartic proteinase ... [more ▼]

The Pregnancy Associated Glycoproteins (PAGs) presented in this paper are largely expressed in the ruminant placenta. These proteins are classified as probably inactive members of the aspartic proteinase family. Pepsinogen, renin, cathepsin E [less ▲]

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See detailRecent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists)
De Tullio, Pascal ULg; Delarge, J.; Pirotte, Bernard ULg

in Current Medicinal Chemistry (1999), 6

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See detailLimit Cycle Oscillation Control and Suppression
Dimitriadis, Grigorios ULg; Cooper, Jonathan E

in Aeronautical Journal (1999), 103(1023), 257-263

The prediction and characterization of the Limit Cycle Oscillation (LCO) behaviour of nonlinear aeroelastic systems has become of great interest recently. However, much of this work has concentrated on ... [more ▼]

The prediction and characterization of the Limit Cycle Oscillation (LCO) behaviour of nonlinear aeroelastic systems has become of great interest recently. However, much of this work has concentrated on determining the existence of LCOs. This paper concentrates on LCO stability. By considering the energy present in di®erent limit cycles, and also using the Harmonic Balance Method, it is shown how the stability of limit cycles can be determined. The analysis is then extended to show that limit cycles can be controlled, or even suppressed, by the use of suitable excitation signals. A basic control scheme is developed to achieve this, and is demonstrated on a simple simulated nonlinear aeroelastic system. [less ▲]

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See detailLifetime measurements in Yb II with time-resolved laser spectroscopy
Li, Z. S.; Svanberg, S.; Quinet, Pascal ULg et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1999), 32

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See detailHypo- et hypertension intracrânienne bénigne
DELVAUX, Valérie ULg; DIOH, Alioune ULg; Schoenen, Jean ULg

in Revue Médicale de Liège (1999), 54(8), 671-676

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See detailFrom Neural Stem Cells to Myelinating Oligodendrocytes
Rogister, Bernard ULg; Ben Hur, Tamir; Dubois-Dalcq, Monique

in Molecular & Cellular Neuroscience [=MCN] (1999), 14

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See detailDerived Projective Limits of Topological Abelian Groups
Prosmans, Fabienne ULg

in Journal of Functional Analysis (1999), 162(1), 135-177

We prove that the category of topological Abelian groups is quasi-Abelian. Using results about derived projective limits in quasi-Abelian categories, we study exactness properties of the projective limit ... [more ▼]

We prove that the category of topological Abelian groups is quasi-Abelian. Using results about derived projective limits in quasi-Abelian categories, we study exactness properties of the projective limit functor in the category of topological Abelian groups. [less ▲]

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See detailRadio-oncologie et radiothérapie. Confirmation de l'efficacité des radiations ionisantes en oncologie, et renouveau de leur intérêt dans les affections non oncologiques : Acquisitions thérapeutiques 1998
OZSAHIN; MIRIMANOFF; PICA, A et al

in Médecine et Hygiène (1999), 54(2238), 100-111

En 1998, plusieurs études ont clarifié ou confirmé l'effet positif de la radiothérapie dans le cancer du sein in situ, dans différents types de lymphomes non hodgkinien et hodgkinien, et dans le cancer ... [more ▼]

En 1998, plusieurs études ont clarifié ou confirmé l'effet positif de la radiothérapie dans le cancer du sein in situ, dans différents types de lymphomes non hodgkinien et hodgkinien, et dans le cancer bronchique à petites cellules. Deux métaanalyses par contre semblent remettre en cause la radiothérapie, dans la maladie de Hodgkin de stade avancé et dans l'approche postopératoire du cancer ronchique à non petites cellules. Ces méta-analyses comportent toutefois d'importantes faiblesses et doivent être interprétées de façon critique. Dans le domaine technique de la radio-oncologie, les progrès spectaculaires de la planification assistée par ordinateur et l'intégration de l'imagerie IRM peuvent maintenant s'appliquer aussi à la curiethérapie. Enfin, la radiothéraple dans les affections non oncologiques suscite un nouvel intérêt, comme par exemple la curiethérapie intracoronarienne, un traitement prometteur pour prévenir la resténose coronarienne. [less ▲]

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See detailFrom a New-World Poetics to a New-World Vision: African America in the Works of Edouard Glissant and Caryl Phillips
Ledent, Bénédicte ULg

in Commonwealth : Essays and Studies (1999), 21(2), 29-36

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See detailComment je traite ... une obesite severe et ses anomalies metaboliques par une gastroplastie.
Luyckx, Françoise ULg; Scheen, André ULg; Letiexhe, Michel ULg et al

in Revue Médicale de Liège (1999), 54(3), 138-42

Severe obesity, defined as a body mass index > or = 35 kg/m2, is frequently associated with various biological abnormalities, particularly in the presence of intra-abdominal adiposity. The most important ... [more ▼]

Severe obesity, defined as a body mass index > or = 35 kg/m2, is frequently associated with various biological abnormalities, particularly in the presence of intra-abdominal adiposity. The most important disorders belong to the so-called insulin resistance syndrome, metabolic syndrome or syndrome X: hyperinsulinaemia, impaired glucose tolerance or type 2 diabetes, dyslipidaemias, hyperuricaemia, hyperfibrinogenaemia. All these metabolic abnormalities are considered as cardiovascular risk factors. They are also correlated with the severity of the liver steatosis which is commonly observed in individuals with severe obesity. We report our experience of the evolution of these metabolic abnormalities after a marked weight loss induced by gastroplasty. We will analyse the favourable effects of bariatric surgery on insulin sensitivity, biological components of the metabolic syndrome, type 2 diabetes and liver steatosis. [less ▲]

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See detailThe effects of training on ventilation and blood gases in exercising Thoroughbreds
Roberts, C. A.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1999), 30

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the ... [more ▼]

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the type frequently used for Thoroughbred racehorses in Great Britain. Standardized treadmill exercise tests (2 min canter at 8 and 10 m/s C8 and C10[ and 2 min gallop at 12 m/s [G12], on a level surface) were performed prior to and after 16 weeks of training. Respiratory flow rates were measured using ultrasound flow transducers. Blood samples were drawn from a transverse facial artery and the right atrium. Minute ventilation, respiratory frequency and tidal volume were not significantly altered by training. Peak inspiratory flow rate was lower following training at 8 and 10 m/s, but not at 12 m/s. Arterial oxygen tension was decreased during trot and canter following training. Blood lactate concentration post G12 decreased following training (10.5 +/- 2.2 mmol/l vs. 7.7 +/- 2.2 mmol/l; P < 0.05). The increase in the degree of exercise-induced arterial hypoxaemia following training may reflect a lack of pulmonary adaptation to training in the face of improved cardiovascular and muscular function. [less ▲]

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See detailImpaired motor coordination and Purkinje cell excitability in mice lacking calretinin
Schiffmann, Serge N.; Cheron, Guy; Lohoff, Ann et al

in Proceedings of the National Academy of Sciences of the United States of America (1999), 96

n the cerebellum, the parallel fiber-Purkinje cell synapse can undergo long-term synaptic plasticity suggested to underlie motor learning and resulting from variations in intracellular calcium ... [more ▼]

n the cerebellum, the parallel fiber-Purkinje cell synapse can undergo long-term synaptic plasticity suggested to underlie motor learning and resulting from variations in intracellular calcium concentration ([Ca2+]i). Ca2+ binding proteins are enriched in the cerebellum, but their role in information processing is not clear. Here, we show that mice deficient in calretinin (Cr-/-) are impaired in tests of motor coordination. An impairment in Ca2+ homeostasis in Cr-/- Purkinje cells was supported by the high Ca2+-saturation of calbindin-D28k in these cells. The firing behavior of Purkinje cells is severely affected in Cr-/- alert mice, with alterations of simple spike firing rate, complex spike duration, and simple spike pause. In contrast, in slices, transmission at parallel fiber- or climbing fiber-Purkinje cell synapses is unaltered, indicating that marked modifications of the firing behavior in vivo can be undetectable in slice. Thus, these results show that calretinin plays a major role at the network level in cerebellar physiology [less ▲]

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See detailStudies of the glutathione S-transferases activities and their localisation in Adalia bipunctata L. (Coleoptera : Coccinellidae).
Francis, Frédéric ULg; Broon, D.; Haubruge, Eric ULg

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (1999), 64(3a), 349-355

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See detailTraitement antimigraineux: présent et avenir
Schoenen, Jean ULg

in Revue Médicale de Liège (1999), 54(2), 79-86

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See detailTroubles psychiatriques et dangerosité
Papart, Patrick ULg

in Acta Psychiatrica Belgica (1999), 99

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See detailA Basis for Using Fire Modeling with 1-D Thermal Analyses of Partitions to Simulate 2-D and 3-D Structural Performance in Real Fires
Cooper, Len; Franssen, Jean-Marc ULg

in Fire Safety Journal (1999), 33

A basis is presented for identifying partition design for which: 1) the use of one-dimensional thermal analysis in the fire modeling part of the problem would lead to reliable simulations of the fire ... [more ▼]

A basis is presented for identifying partition design for which: 1) the use of one-dimensional thermal analysis in the fire modeling part of the problem would lead to reliable simulations of the fire environment, and 2) the resulting simulations can be used to provide the necessary boundary conditions input to solve the thermal/structural part of the problem, using two- or three-dimensional analyses, as required. [less ▲]

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See detailbeta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: Relevance to Alzheimer's disease
Pillot, T.; Goethals, M.; Najib, J. et al

in Journal of Neurochemistry (1999), 72(1), 230-7

Growing evidence indicates the involvement of apolipoprotein E (apoE) in the development of late-onset and sporadic forms of Alzheimer's disease, although its exact role remains unclear. We previously ... [more ▼]

Growing evidence indicates the involvement of apolipoprotein E (apoE) in the development of late-onset and sporadic forms of Alzheimer's disease, although its exact role remains unclear. We previously demonstrated that beta-amyloid peptide (Abeta) displays membrane-destabilizing properties and that only apoE2 and E3 isoforms inhibit these properties. In this study, we clearly demonstrate that the carboxy-terminal lipid-binding domain of apoE (e.g., residues 200-299) is responsible for the Abeta-binding activity of apoE and that this interaction involves pairs of apoE amphipathic alpha-helices. We further demonstrate that Abeta is able to inhibit the association of the C-terminal domain of apoE with lipids due to the formation of Abeta/apoE complexes resistant to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. On the contrary, the amino-terminal receptor-binding domain of apoE (e.g., residues 129-169) is not able to form stable complexes with Abeta. These data extend our understanding of human apoE-dependent binding of Abeta by involving the C-terminal domain of apoE in the efficient formation of apoE/Abeta complex. [less ▲]

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See detailUpdates in CT and MRI : the elbows
Snaps, Frédéric ULg; Reichle, J.

in Clinical Techniques in Small Animal Practice (1999), 14(3), 177-186

Computed tomography (CT) and magnetic resonance imaging (MRI) are noninvasive methods of imaging the canine cubital joint. CT images are typically acquired using contiguous 1-mm slices, a bone ... [more ▼]

Computed tomography (CT) and magnetic resonance imaging (MRI) are noninvasive methods of imaging the canine cubital joint. CT images are typically acquired using contiguous 1-mm slices, a bone reconstruction algorithm, and a field of view large enough to scan both elbows simultaneously. CT provides a detailed assessment of the medial coronoid process (MCP), radial incisure, anconeal process, and trochlear notch of the ulna; the humeral condyle; joint congruity; and osteoarthrosis. With MRI, use of a surface coil and 3D Fourier transformation gradient echo fast imaging sequences allow contiguous thin slices to be obtained. Both imaging techniques appear to be highly effective in the evaluation of elbow dysplasia, particularly for the detection of MCP fragmentation, although MRI is superior to CT for identifying nonmineralized cartilaginous fragments. [less ▲]

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See detailMalathion Resistance Increases Male Reproductive Success In Tribolium Castaneum (Coleoptera : Tenebrionidae)
Arnaud, L.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Annales de la Societe Entomologique de France (1999), 35

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See detailTreatment of osteoporosis : where are we and where are we going to
Reginster, Jean-Yves ULg

in Morphologie : Bulletin de l'Association des Anatomistes (1999), 83(261), 41-5

In the past years, there has been a multiplication of drugs identified as candidates for use in the prevention or the treatment of osteoporosis. When treating established osteoporosis, the objective is to ... [more ▼]

In the past years, there has been a multiplication of drugs identified as candidates for use in the prevention or the treatment of osteoporosis. When treating established osteoporosis, the objective is to prevent further skeletal deterioration, improve bone mass and/or bone microarchitecture to provide a documented reduction of the risk of vertebral and/or peripheral fractures. Calcium and vitamin D have been shown to be particularly efficient in elderly patients, mainly to prevent non-vertebral fractures. By inhibiting osteoclastic activity, calcitonin improves bone mineral density at all sites. Preliminary results suggest that it might also decrease vertebral fracture rates. Bisphosphonates have been investigated for 20 years in the treatment of osteoporosis. Alendronate was shown to reduce spinal and extravertebral fractures. New formulations of fluoride, like monofluorophosphate appear to be particularly beneficial in women with mild to moderate osteoporosis. Several new compounds, including parathormone, strontium salts, ipriflavone or others are currently developed and subject to large investigational programs to demonstrate their ability to reduce fracture. [less ▲]

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See detailExperimental and theoretical radiative lifetimes, branching fractions and oscillator strengths in Lu II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Monthly Notices of the Royal Astronomical Society (1999), 307

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See detailKarst dans les micaschistes d'Akok Bekoé - Sud Cameroun
Willems, Luc ULg; Vicat, Jean-Paul; Pouclet, André

in Bulletin de la Société Géographique de Liège (1999), 37(2), 5-18

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those ... [more ▼]

50 km south of Yaoundé, karst phenomena are developed in micaschists. A network of fractures dependent in thrusting area guided formation of caves, conduits and other morphologies comparable with those found in the karst limestones. The presence of a spring and the proximity of the Nyong river suggest that a chemical erosion within an aquifer is at the origin of most of forms. The position of certain conduits and tafonis dismisses the assumption of a genesis within a weathering mantle. [less ▲]

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See detailDiagnostiquer les Troubles Spécifiques de l'Apprentissage
Garcet, Serge ULg

in Revue Scientifique de l'AIGS, (1999), 2

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See detailRecurrent abortion. Etiology and occurrence
VAN LINTHOUT, Christine ULg; Ahrendt, J.

in Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg (1999), (2), 59-71

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See detailLa dysplasie fibromusculaire
VAN DAMME, Hendrik ULg; Quaniers, Janine ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1999), 54(12), 935-42

Fibromuscular dysplasia is a rare non-atherosclerotic, non-inflammatory arterial disease. It concerns less than 1% of all occlusive artery lesions, but is more common in young female patients, with a ... [more ▼]

Fibromuscular dysplasia is a rare non-atherosclerotic, non-inflammatory arterial disease. It concerns less than 1% of all occlusive artery lesions, but is more common in young female patients, with a prevalence of 3 to 5% of the arterial lesions in that age group. It mainly attains renal and carotid arteries. The authors discuss the etiopathogeny, the prevalence and treatment of fibromuscular dysplasia. Their own surgical experience with 21 renal and 10 carotid lesions of fibromuscular is exposed. [less ▲]

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See detailCharacterizations by automorphism groups of some rank 3 buildings - IV: Hyperbolic p-adic Moufang buildings of rank 3
Van Maldeghem, H.; Van Steen, Kristel ULg

in Geometriae Dedicata (1999), 75(2), 115-122

In this paper, we introduce the p-adic Moufang condition for hyperbolic buildings of rank 3. It is the most obvious and simplest generalization of the p-adic Moufang condition for affine buildings ... [more ▼]

In this paper, we introduce the p-adic Moufang condition for hyperbolic buildings of rank 3. It is the most obvious and simplest generalization of the p-adic Moufang condition for affine buildings, introduced in Part III of this sequence of papers. We show that p is very restricted, which confirms (but does not prove) the conjecture that no p-adic analogue is possible for the construction of Moufang (hyperbolic) buildings by Ronan and Tits. [less ▲]

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See detailRadiothérapie externe ou anti-inflammatoire non-stéroïdien pour la prévention des ossifications hétérotopiques après prothèse totale de hanche?
Zouhair, A; Ozsahin, M; Mouhsine, E et al

in Schweizerische Medizinische Wochenschrift (1999), 129(9), 370-376

External radiotherapy or non-steroid antiinflammatory drugs for prevention of heterotopic ossification following total hip replacement Heterotopic ossification (HO) is defined as the development of ... [more ▼]

External radiotherapy or non-steroid antiinflammatory drugs for prevention of heterotopic ossification following total hip replacement Heterotopic ossification (HO) is defined as the development of abnormal ossification in soft tissues. HO is a common disease after total hip replacement. Many therapeutic modalities have been proposed to prevent HO. The most commonly used modalities are nonsteroidal anti-inflammatory drugs (NSAID) or ionizing radiation administered just before or immediately after total hip replacement. As far as external radiation therapy is concerned, there are several published randomized studies aimed at investigating its efficacy and timing related to surgery, and at comparing ionizing irradiation to NSAID. In this article we review the published data in order to define guidelines which could be used in daily practice for the choice of prophylactic treatment against HO. [less ▲]

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See detailSymbolic Verification of Communication Protocols with Infinite State Spaces using QDDs
Boigelot, Bernard ULg; Godefroid, Patrice

in Formal Methods in System Design (1999), 14(3), 237-255

We study the verification of properties of communication protocols modeled by a finite set of finite-state machines that communicate by exchanging messages via unbounded FIFO queues. It is well-known that ... [more ▼]

We study the verification of properties of communication protocols modeled by a finite set of finite-state machines that communicate by exchanging messages via unbounded FIFO queues. It is well-known that most interesting verification problems, such as deadlock detection, are undecidable for this class of systems. However, in practice, these verification problems may very well turn out to be decidable for a subclass containing most "real" protocols. Motivated by this optimistic (and, we claim, realistic) observation, we present an algorithm that may construct a finite and exact representation of the state space of a communication protocol, even if this state space is infinite. Our algorithm performs a loop-first search in the state space of the protocol being analyzed. A loop-first search is a search technique that attempts to explore first the results of successive executions of loops in the protocol description (code). A new data structure named Queue-content Decision Diagram (QDD) is introduced for representing (possibly infinite) sets of queue-contents. Operations for manipulating QDDs during a loop-first search are presented. A loop-first search using QDDs has been implemented, and experiments on several communication protocols with infinite state spaces have been performed. For these examples, our tool completed its search, and produced a finite symbolic representation for these infinite state spaces. [less ▲]

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See detailUn réformateur lotharingien de choc : l'abbé Poppon de Stavelot (978-1048)
George, Philippe ULg

in Revue Mabillon (1999)

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See detailPseudoscalar vertex, Goldstone boson and quark masses on the lattice
Cudell, Jean-René ULg; Le Yaouanc, A.; Pittori, Carlotta

in Physics Letters B (1999), 454

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See detailContribution à l'étude de la flore des grottes de Belgique.
Garbacki, Nancy ULg; Ector, Luc; Kostikov, Igor et al

in Belgian Journal of Botany (1999), 132(1), 43-76

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See detailcompte rendu de : J. Sosephson, The Pahlavi Translation Technique as Illustrated by Hom Yast
Rochette, Bruno ULg

in Translatio (1999), 18(2), 294-297

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See detailMécanismes de l'action hypnotique des agents anesthésiques
Bonhomme, Vincent ULg; Brichant, Jean-François ULg; Dewandre, Pierre-Yves ULg et al

in Praticien en Anesthésie Réanimation (Le) (1999), 3

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See detailThe Molecular Neuron-Glia Couple and Epileptogenesis
Grisar, Thierry ULg; Lakaye, Bernard ULg; Thomas, E. et al

in Advances in Neurology (1999), 79

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See detailReproducibility of measurements of potential doubling time of tumour cells in the multicentre National Cancer Institute protocol
COUCKE, Philippe ULg; Paschoud, N; Pavy, J-J et al

in British Journal of Cancer (1999)

We compared the flow cytometric measurement and analysis of the potential doubling time ( Tpot) between three centres involved in the National Cancer Institute (NCI) protocol T92-0045. The primary purpose ... [more ▼]

We compared the flow cytometric measurement and analysis of the potential doubling time ( Tpot) between three centres involved in the National Cancer Institute (NCI) protocol T92-0045. The primary purpose was to understand and minimize the variation within the measurement. A total of 102 specimens were selected at random from patients entered into the trial. Samples were prepared, stained, run and analysed in each centre and a single set of data analysed by all three centres. Analysis of the disc data set revealed that the measurement of labelling index (LI) was robust and reproducible. The estimation of duration of S-phase ( Ts) was subject to errors of profile interpretation, particularly DNA ploidy status, and analysis. The LI dominated the variation in Tpot such that the level of final agreement, after removal of outliers and ploidy agreement, reached correlation coefficients of 0.9. The sample data showed poor agreement within each of the components of the measurement. There was some improvement when ploidy was in agreement, but correlation coefficients failed to exceed values of 0.5 for Tpot. The data suggest that observer-associated analysis of Ts and tissue processing and tumour heterogeneity were the major causes of variability in the Tpot measurement. The first two aspects can be standardized and minimized, but heterogeneity will remain a problem with biopsy techniques. [less ▲]

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See detailOncologie gastro-intestinale
Coucke, Philippe ULg; FREI; FELLEY et al

in Médecine et Hygiène (1999), 57(2240), 213-217

Même si aucune acquisition nouvelle n'est venue embaumer l'atmosphère encore trop souvent grisâtre de l'oncologie gastro-intestinale en 1998, la nécessité d'un consilium préthérapeutique associant ... [more ▼]

Même si aucune acquisition nouvelle n'est venue embaumer l'atmosphère encore trop souvent grisâtre de l'oncologie gastro-intestinale en 1998, la nécessité d'un consilium préthérapeutique associant chirurgiens, endoscopeurs, oncologues et radio-oncologues s'impose avec encore plus de fermeté, pour tous les cancers digestifs. Les patients devraient autant que possible être inclus dans des protocoles d'études bien conduits et bénéficier d'une chirurgie oncologique optimale. [less ▲]

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See detailClassification of medicines according to their influence on driving ability
Maes, V.; Grenez, O.; Charlier, Corinne ULg et al

in Acta Clinica Belgica (1999), S1

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See detailAlcoholic's deficit in the decoding of emotional facial expression
Philippot, P; Kornreich, C; Blairy, Sylvie ULg et al

in Alcoholism, Clinical & Experimental Research (1999), 23(6), 1031-1038

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detailEffects Of Galanin Infusion On Gh Secretion And Ghrh-Induced Gh Release In Prepubertal Male Lambs
Saleri, R.; Baratta, M.; Renaville, Robert ULg et al

in Small Ruminant Research (1999), 33(3),

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See detailLe sens de la mesure
Lafontaine, Dominique ULg

in Echec à l'Echec (1999), (133), 14

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See detailPerturbative evolution and Regge behaviour
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P. V.

in Physics Letters B (1999), 448

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