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See detailLes antagonistes des récepteurs de l'angiotensine II
Krzesinski, Jean-Marie ULg

in Vaisseaux, Coeur, Poumons (1998), 3(4), 116-119

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See detailInterfacial Properties Of Gluten Monolayers Spread On Various Chloride Salt Solutions. Effects Of Electrolytes, Salt Concentrations, And Temperature
Balla, A.; Razafindralambo, Hary ULg; Blecker, Christophe ULg et al

in Journal of Agricultural and Food Chemistry (1998), 46(9), 3535-3539

The interfacial behavior of gluten powder spread as a monolayer on aqueous phases containing various chloride salts was studied. The presence of electrolytes at low concentrations reduced the expansion ... [more ▼]

The interfacial behavior of gluten powder spread as a monolayer on aqueous phases containing various chloride salts was studied. The presence of electrolytes at low concentrations reduced the expansion and stability of the gluten monolayers compared to the results obtained with pure water. At low salt concentrations, no effect of the electrolyte nature was detectable (compression curves were superimposed for Na+, K+, and Ca2+). However, when salt concentrations increased from 0.05 to 0.5 M, the influence of the electrolyte nature on gluten film expansion appeared clearly. Divalent cations (Ca2+) gave films with greater expansion than monovalent cations (K+, Na+). Between the monovalent cations, Na+ had a greater effect on gluten film expansion than did K+. Gluten monolayer expansion evaluated by limiting the area (A0) passed through a minimum when the salt concentrations increased from 0 to 0.5 M. The temperature also influenced the behavior of gluten monolayers as attested by A0 and film elasticity values which decreased with temperature. The energy of compression (ΔGc) that measures the intermolecular forces between film-forming molecules was generally higher on Ca2+ than on K+ and Na+, showing that Ca2+ induced stronger interactions than K+ or Na+. The ΔGc − T plots showed that the compression of gluten films on various electrolytes led to ordered structures. [less ▲]

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See detailL'enseignement des sciences. UN défi pour notre système éducatif
Monseur, Christian ULg; Demeuse, Marc

in Athena (1998)

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See detailInterface between anti-dumping policy and competition policy: A case study
Tharakan, P. K. M.; Vermulst, Edwin; Tharakan, Joseph ULg

in World Economy (1998)

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See detailFeeding in darkness alleviates density-dependent growth of juvenile vundu catfish Heterobranchus longifilis (Clariidae)
Baras, E.; Tissier, F.; Westerloppe, L. et al

in Aquatic Living Resources (1998), 11

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See detailFacilitatory effects of chronically administered citicoline on learning and memory processes in the dog.
Bruhwyler, J.; Liégeois, Jean-François ULg; Geczy, J.

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (1998), 22(1), 115-28

1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment ... [more ▼]

1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment. 2. This study aimed to evaluate the effects of citicoline on learning and retrieval processes in a complex differential reinforcement of response duration schedule in normal dogs. 3. The effects of citicoline on a stabilized performance were also measured in order to be able to differentiate specific memory effects from non specific influences on the motor, neuro-vegetative and motivational systems. 4. The results demonstrate that citicoline can exert facilitatory effects on learning and memory but also on retrieval processes. The complete absence of effects on the stabilized performance and on the motor, neuro-vegetative and motivational systems constitutes arguments in favour of a selectivity of action on the memory processes. [less ▲]

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See detailTraumatismes crâniens et épilepsie
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Percentile (1998), 3(1), 29-32

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See detailLe nouveau Trésor de la Cathédrale de Liège
George, Philippe ULg; Pirenne, Françoise

in Feuillets de la Cathédrale de Liège (1998)

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See detailInfluence de facteurs abiotiques ou biotiques sur l'evaluation de la sensibilite d'Aphidius rhopalosiphi De Stefani-Perez a la phosalone.
Guelton, O.; Deleu, R.; Schiffers, Bruno ULg et al

in Parasitica (1998), 54(2-3),

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des ... [more ▼]

MEAD-BRIGGS (1992) a proposé une méthode de laboratoire permettant d'évaluer la toxicité de contact d'un pesticide à l'égard d'Aphidius rhopalosiphi De Stefani-Perez, un parasitoïde des pucerons des céréales. L'influence de l'humidité relative, de la photo période, du mode de conservation des momies ainsi que du sexe des insectes sur la sensibilité des parasitoïdes à la phosalone a été étudiée. L'humidité relative influence le plus la sensibilité des insectes lors des essais, le mode de conservation des momies se révèle important lui aussi. [less ▲]

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See detailGalloping of electrical lines in wind tunnel facilities
Chabart, Olivier; Lilien, Jean-Louis ULg

in Journal of Wind Engineering & Industrial Aerodynamics (1998), 74-76

Galloping on power lines is a difficult matter. In this paper a galloping has been reproduced in a wind tunnel on a section of an actual conductor with actual ice shape. Aerodynamics is first detailed ... [more ▼]

Galloping on power lines is a difficult matter. In this paper a galloping has been reproduced in a wind tunnel on a section of an actual conductor with actual ice shape. Aerodynamics is first detailed. Then flutter type and Den Hartod type galloping has been obtained in the wind tunnel depending on changeable ratio vertical to torsional frequencies. [less ▲]

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See detailConservative Mutations In The Immunosuppressive Region Of The Bovine Leukemia Virus Transmembrane Protein Affect Fusion But Not Infectivity In Vivo
GATOT, Jean-Stéphane ULg; Callebaut, I.; Mornon, Jp. et al

in Journal of Biological Chemistry (1998), 273(21),

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See detailStudies on the value of incorporating the effect of dominance in genetic evaluations of dairy cattle, beef cattle and swine
Misztal, I.; Varona, L.; Culbertson, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2

Nonadditive genetic effects are currently ignored in national genetic evaluations of farm animals because of ignorance of the level of dominance variance for traits of interest and the difficult ... [more ▼]

Nonadditive genetic effects are currently ignored in national genetic evaluations of farm animals because of ignorance of the level of dominance variance for traits of interest and the difficult computational problems involved. Potential gains from including the effects of dominance in genetic evaluations include “purification” of additive values and availability of predictions of specific combining abilities for each pair of prospective parents. This study focused on making evaluation with dominance effects feasible computationally and on ascertaining benefits of such an evaluation for dairy cattle, beef cattle, and swine. Using iteration on data, computing costs for evaluation with dominance effects included costs could be less than twice expensive as with only an additive model. With Method Â, variance components could be estimated for problems involving up to 10 millions equations. Dominance effects accounted for up to 10% of phenotypic variance; estimates were larger for growth traits. As a percentage of additive variance, the estimate of dominance variance reached 78% for 21-d litter weight of swine and 47% for post weaning weight of beef cattle. When dominance effects are ignored, additive evaluations are “contaminated”; effects are greatest for evaluations of dams in a single large family. These changes in ranking were important for dairy cattle, especially for dams of full-sibs, but were less important for swine. Specific combining abilities cannot be included in sire evaluations and need to be computed separately for each set of parents. The predictions of specific combining abilities could be used in computerized mating programs via the Internet. Gains from including the dominance effect in genetic evaluations would be moderate but would outweigh expenditures to produce those evaluations. [less ▲]

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See detailFree fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria.
Sluse, Francis ULg; Almeida, A. M.; Jarmuszkiewicz, W. et al

in FEBS Letters (1998), 433

Two energy-dissipating systems, an alternative oxidase and an uncoupling protein, are known to exist in plant mitochondria. In tomato fruit mitochondria linoleic acid, a substrate for the uncoupling ... [more ▼]

Two energy-dissipating systems, an alternative oxidase and an uncoupling protein, are known to exist in plant mitochondria. In tomato fruit mitochondria linoleic acid, a substrate for the uncoupling protein, inhibited the alternative oxidase-sustained respiration and decreased the ADP/O ratio to the same value regardless of the level of alternative oxidase activity. Experiments with varying concentrations of linoleic acid have shown that inhibition of the alternative oxidase is more sensitive to the linoleic acid concentration than the uncoupling protein activation. It can be proposed that these dissipating systems work sequentially during the life of the plant cell, since a high level of free fatty acid-induced uncoupling protein activity excludes alternative oxidase activity. [less ▲]

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See detailEvidence for behavioral sensitization to cocaine in preweanling rat pups
Wood, R. D.; Tirelli, Ezio ULg; Snyder, K. J. et al

in Psychopharmacologia (1998), 138(2), 114-123

Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to ... [more ▼]

Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to postnatal day 20 with 0, 5, 15, or 30 mg/kg cocaine hydrochloride and placed for 30 min in either the experimental chamber or home cage. On postnatal day 21 (test day), Ss were challenged with either 15 mg/kg cocaine or saline prior to placement in the experimental chamber. Significant sensitization of cocaine-induced stereotyped head movements was evident in animals given 15 or 30 mg/kg chronically in the experimental chamber, but not when these same doses were given in the home cage. Less consistent evidence for cocaine-induced sensitization was seen when examining locomotion, although trends for sensitization of this behavior were seen in animals chronically injected in either the test chamber or home cage. Thus, preweanlings can exhibit cocaine sensitization, particularly in terms of stereotypy, when tested shortly after the chronic exposure period, with expression of this sensitization being facilitated by pairing the chronic injections with the test context. ((c) 1998 APA/PsycINFO, all rights reserved) [less ▲]

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See detailThe Pathophysiology of Migraine: A Review Based on the Literature and on Personal Contributions
Schoenen, Jean ULg

in Functional Neurology (1998), 13(1, Jan-Mar), 7-15

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See detailCooper pair-like systems at high temperature and their role on fluctuations near the critical temperature
Ausloos, Marcel ULg; Dorbolo, Stéphane ULg

in International Journal of Modern Physics B : Condensed Matter Physics, Statistical Physics, Applied Physics (1998), 12

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See detailStudy of siliceous karst genesis in Eastern Niger. Microscopy and analysis of speleothems
Willems, Luc ULg; Compère, Philippe ULg; Sponholz, Barbara

in Zeitschrift für Geomorphologie (1998), 42(2), 129-142

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See detailDiagnostic des troubles fonctionnels et inflammatoires chroniques des petites voies aériennes
Art, Tatiana ULg; Amory, Hélène ULg; Duvivier, D. H. et al

in Pratique Vétérinaire Equine (1998), 30

Faced with the numerous respiratory dysfunctions, there is a large variety of investigation techniques. None is sufficient. Each has its specific application, its advantages and its drawbacks. Detection ... [more ▼]

Faced with the numerous respiratory dysfunctions, there is a large variety of investigation techniques. None is sufficient. Each has its specific application, its advantages and its drawbacks. Detection of disorders associated with inflammation of small air ways (bronchos¬pasm, pulmonary vasoconstriction, bronchial hyper-reactivity) is a first step. The field examinations Wow: arterial blood gases (which give a global appreciation of the pulmonary function), LTB and LBA (which may characterize the pathogenic agent), endoscopy and biop¬sy are the most useful. Then, a battery of tests is used, performed in a very specialized infrastructure : scanning, ventilation mechanics... which allow to evaluate the state of the respiratory apparatus. Finally, the tests during effort help to evaluate, more specifically, the effects of a treatment [less ▲]

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See detailA formal definition of time in LOTOS (Full version)
Léonard, Luc; Leduc, Guy ULg

in Formal Aspects of Computing (1998), 10E

Enhanced Timed-LOTOS, denoted ET-LOTOS, is an extension of LOTOS that allows the modelling of real-time behaviours. It covers all the aspects of full LOTOS, including data types, it supports both a dense ... [more ▼]

Enhanced Timed-LOTOS, denoted ET-LOTOS, is an extension of LOTOS that allows the modelling of real-time behaviours. It covers all the aspects of full LOTOS, including data types, it supports both a dense and a discrete time domain and can manipulate time values as any other data values. A tutorial on ET-LOTOS, showing many application examples, has already been published elsewhere. The present paper adds to it by providing an in-depth presentation of its theoretical aspects. The complete semantics is given and explained, and its properties are studied. In particular, we prove that the semantics is consistent and that strong bisimulation is a congruence. This requires to deal carefully with the presence of negative premises in the operational semantics, which are necessary to express urgency. ET-LOTOS is also shown to be a conservative extension of LOTOS for guarded processes, and is the basis of the timed extension of LOTOS currently developed by ISO. To our knowledge, this is the first in-depth study of a language that combines data types and real-time behaviours. [less ▲]

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See detailGround-based infrared solar spectroscopic measurements of carbon monoxide during 1994 Measurement of Air Pollution From Space flights
Pougatchev, N. S.; Jones, N. B.; Connor, B. J. et al

in Journal Of Geophysical Research. Atmospheres (1998), 103(D15), 19317-19325

Results of the comparison of carbon monoxide ground-based infrared solar spectroscopic measurements with data obtained during 1994 Measurement of Air Pollution From Space (MAPS) flights are presented ... [more ▼]

Results of the comparison of carbon monoxide ground-based infrared solar spectroscopic measurements with data obtained during 1994 Measurement of Air Pollution From Space (MAPS) flights are presented. Spectroscopic measurements were performed correlatively with April and October MAPS flights by nine research groups from Belgium, Canada, Germany, Japan, New Zealand, Russia, and the United States. Characterization of the techniques and error analysis were performed. The role of the CO a priori profile used in the retrieval was estimated. In most cases an agreement between spectroscopic and MAPS data is within estimated MAPS accuracy of +/-10%. [less ▲]

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See detailEvolution des effectifs des Tétras lyres (Tetrao tetrix) dans les Hautes-Fagnes de Belgique
Ruwet, J. C.; Charlet, O.; Groulard, J. M. et al

in Cahiers d'Ethologie (1998), 18(1),

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See detail3 ',4 ',5 ',6 ' tetradehydrolongicaudatine Y, an anhydronium base from Strychnos usambarensis
Frederich, Michel ULg; Quetin-Leclercq, J.; Biala, R. G. et al

in Phytochemistry (1998), 48(7), 1263-1266

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See detailDefects segmentation on 'Golden Delicious' apples by using colour machine vision
Leemans, Vincent ULg; Magein, Hugo ULg; Destain, Marie-France ULg

in Computers & Electronics in Agriculture (1998), 20(2), 117-130

A method based on colour information is proposed to detect defects on 'Golden Delicious' apples. In a first step, a colour model based on the variability of the normal colour is described. To segment the ... [more ▼]

A method based on colour information is proposed to detect defects on 'Golden Delicious' apples. In a first step, a colour model based on the variability of the normal colour is described. To segment the defects, each pixel of ail apple image is compared with the model. If it matches the pixel, it is considered as belonging to healthy tissue, otherwise as a defect. Two other steps refine the segmentation, using either parameters computed on the whole fruit, or values computed locally. Some results are shown and discussed. The algorithm is able to segment a wide range of defects. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailComment on "Stratification dynamics in wastewater stabilization ponds", by R. Gu and H.G. Stefan
Djenidi, Salim ULg

in Water Research (1998), 32(1), 261-262

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See detailCharacterizations by automorphism groups of some rank 3 buildings - I. Some properties of half strongly-transitive triangle buildings
Van Maldeghem, H.; Van Steen, Kristel ULg

in Geometriae Dedicata (1998), 73(2), 119-142

In a sequence of papers, we will show that the existence of a (half) strongly-transitive automorphism group acting on a locally finite triangle building Delta forces Delta to be one of the examples ... [more ▼]

In a sequence of papers, we will show that the existence of a (half) strongly-transitive automorphism group acting on a locally finite triangle building Delta forces Delta to be one of the examples arising from PSL3(K) for a locally finite local skewfield K. Furthermore, we introduce some Moufang-like conditions in affine buildings of rank 3, and characterize those examples arising from algebraic,classical or mixed type groups over a local field. In particular, we characterize the p-adic-like affine rank 3 buildings by a certain p-adic Moufang condition, and show that such a condition has zero probability to survive in hyperbolic rank 3 buildings. This shows that a construction of hyperbolic buildings as analogues of p-adic affine buildings is very unlikely to exist. Mathematics Subject Classifications (1991): 51E24, 51C05. [less ▲]

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See detailCrystal-field effects on the thermal conductivity of localized spin metallic compounds
Rassili, Ahmed ULg; Durczewski, K.; Ausloos, Marcel ULg

in Physical Review. B : Condensed Matter (1998), 58(9), 5665-5671

The influence of the crystal-electric-field (CEF) splitting on the thermal conductivity is calculated on the basis of a two-level system model applicable to intermetallic magnetic compounds. The localized ... [more ▼]

The influence of the crystal-electric-field (CEF) splitting on the thermal conductivity is calculated on the basis of a two-level system model applicable to intermetallic magnetic compounds. The localized spin scattering contribution kappa(s), in a manner similar to the total electronic thermal conductivity kappa(e), shows a larger increase at low and intermediate temperatures as compared to the case iii which-no crystal-electric-field splitting is taken into account. The influence of some theoretical parameters is also discussed. It is shown that the CEF effect enhances the effect of the magnetic scattering potential, and impurity contributions screen such an enhancement at temperatures below the Debye temperature. Other scattering contributions, e.g., electron-phonon and electron impurities, are also taken into account in our calculation. The theory is in quantitative agreement with data on RA1(2) systems taken as test cases, and leads to values of the level splitting in the 50 K range. [less ▲]

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See detailSilicone tissue-expander prosthesis (STEP) to protect the small bowel during radiation therapy for uterine malignancies.
Zouhair, A; Delaloye, J-F; Ozsahin, M et al

in Radiotherapy & Oncology (1998), 48(Supp1), 103

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See detailMammals from the Azores islands (Portugal): an updated overview
Mathias, Maria da Luz; Ramalhinho, Maria Graça; Santos-Reis, Margarida et al

in Mammalia (1998), 62(3), 397-407

Nine species of mammals are recorded for the Azores islands: one insectivore (Erinaceus europaeus), two bats (Myotis myotis, Nyctalus azoreum), one lagomorph (Oryctolagus cuniculus), three rodents (Rattus ... [more ▼]

Nine species of mammals are recorded for the Azores islands: one insectivore (Erinaceus europaeus), two bats (Myotis myotis, Nyctalus azoreum), one lagomorph (Oryctolagus cuniculus), three rodents (Rattus norvegicus, R. rattus, Mus musculus domesticus) and two carnivores (Mustela nivalis, M. furo). Here, notes on the origin and known distribution are given for each species, together with taxonomical and ecological cmments. Except for bats all the remaining species seem to have been introduced under the influence of the man's exploratory and commercial activities [less ▲]

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See detailPd-Ag/SiO2 sol-gel catalysts designed for selective conversion of chlorinated alkanes into alkenes
Heinrichs, Benoît ULg; Delhez, Patrice; Schoebrechts, Jean-Paul et al

in Studies in Surface Science and Catalysis (1998), 118

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See detailAnother reason why simple discretizations of rotated diffusion operators cause problems in ocean models: Comments on "Isoneutral diffusion in a z-coordinate ocean model"
Beckers, Jean-Marie ULg; Burchard, H.; Campin, J. M. et al

in Journal of Physical Oceanography (1998), 28(7), 1552-1559

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on ... [more ▼]

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on the so-called z-coordinate system is presented. The authors then focus exclusively on the dynamically passive tracers and analyze some different approaches to the numerical discretization. Monotonic schemes are designed but are found to be rather complex, while simpler, linear schemes are shown to produce unphysical undershooting and vershooting. It is suggested that the choice of an appropriate discretization method depends on the importance of the rotated diffusion in a given simulation, whether the field to be diffused is dynamically active or not. [less ▲]

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See detailVascular endothelial growth factor (VEGF) in endometriosis.
Donnez, Jacques; Smoes, Pierre; Gillerot, Stéphane et al

in Human Reproduction (1998), 13(6), 1686-90

Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the peritoneal layer, the establishment ... [more ▼]

Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the peritoneal layer, the establishment of a new blood supply is essential for the survival of the endometrial implant and development of endometriosis. From the known angiogenic factors, vascular endothelial growth factor (VEGF) has emerged as a pivotally important regulator of normal angiogenesis and pathological neovascularization. The VEGF protein was evaluated immunohistochemically in the eutopic endometrium of 10 women without endometriosis (group I) at laparoscopy and the eutopic endometrium and peritoneal endometriotic lesions of 43 women with endometriosis (group II). VEGF histological scores were 9.7 +/- 4.3 and 4.0 +/- 2.6 respectively in the epithelium and stroma of the eutopic endometrium of group I women, and 10.3 +/- 2.3 and 3.6 +/- 2.3 respectively in women of group II. In red lesions, the VEGF scores were 11.1 +/- 3.0 in the epithelium and 5.1 +/- 3.0 in the stroma, and in black lesions were 8.6 +/- 2.7 and 1.6 +/- 1.6, respectively. Significantly lower values were observed in black lesions as compared with eutopic endometrium and red lesions, the values of which were similar. Scores were also evaluated according to the phase of the cycle. In eutopic as well as ectopic endometrium, no significant cyclic variations were observed throughout the cycle. However, VEGF content was found to be higher in the eutopic glandular epithelium of women with endometriosis during the late secretory phase, possibly suggesting a more likely tendency to implant. In contrast, significantly higher VEGF content was noted in red lesions as compared with black lesions. During all phases of the cycle, the VEGF content in stromal cells of red lesions was higher than in black lesions. Similarities in VEGF content were observed in the glandular epithelium of the eutopic endometrium of women with endometriosis and red lesions, suggesting that endometriosis probably arises from the peritoneal seeding of viable endometrial cells during retrograde menstruation and that red lesions can be considered as the first stage of implantation. After the attachment phase, the high VEGF levels could provoke an increase in the subperitoneal vascular network and facilitate implantation and viability in the retroperitoneal space. Lower VEGF levels in black lesions explain the decrease in both stromal vascularization, followed by fibrosis and inactivation of the implant. [less ▲]

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See detailImpairment of mitochondrial functions abolishes NF-kappaB activation by an oxidative stress
Josse, Claire ULg; Legrand-Poels, Sylvie ULg; Piret, Bernard et al

in Free Radical Biology & Medicine (1998)

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See detailGyalideopsis cochlearifer, a new pantropical, commensalistic species on foliicolous Gomphillaceae
Lücking, Robert; Sérusiaux, Emmanuël ULg

in Lichenologist (1998), 30

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See detailPro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency
Pernasetti, Flavia; Milner, Robert DG; al Ashwal, Abdullah A Z et al

in Journal of Clinical Endocrinology and Metabolism (1998), 83(6), 2079-83

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven ... [more ▼]

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven children with GH, PRL, and TSH deficiency from three, reportedly unrelated, Middle Eastern families, harboring a newly recognized Pro- > Ser recessive mutation in codon 239 of the Pit-1 gene. The mutated residue is located at the beginning of the second alpha-helix of the POU-homeodomain and is strictly conserved among all POU proteins. The Pro239Ser mutant binds DNA normally but is unable to stimulate transcription. [less ▲]

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See detailAutomatic Synthesis of [18F]Altanserin, a Radiopharmaceutical for Positron Emission Tomographic Studies of the Serotonergic Type-2 Receptors
Monclus, Michel; Van Naemen, John; Mulleneers, Eric et al

in Clinical Positron Imaging (1998), 1(2), 111-116

[18F]Altanserin is routinely used in several centers to study the serotonergic type-2 receptors (5HT2) with positron emission tomography (PET). An automatic production system allowing the preparation of ... [more ▼]

[18F]Altanserin is routinely used in several centers to study the serotonergic type-2 receptors (5HT2) with positron emission tomography (PET). An automatic production system allowing the preparation of multimillicurie amounts [>1.5 GBq (40 mCi) EOS, mean radiochemical yield 20 ± 6% EOB, specific activity >1 Ci/µmol Image] of this radiopharmaceutical within a synthesis time of 90 minutes (quality controls included) is described in this paper. The apparatus includes the recovery of the activity from the target, the preparation of the dried [18F]KF/kryptofix 2.2.2 complex, the labeling reaction using a microwave cavity, the Sep Pak and HPLC purification. A sterile, pyrogen-free and single use unit was also developed for the formulation of the injectable solution. This last part could be used for the formulation of many other radiopharmaceuticals. [less ▲]

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See detailCompte rendu de G. Serbat, Celse, De la médecine, Paris, 1995
Marganne, Marie-Hélène ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1998), 67

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See detailEléments du diagnostic des parasitoses externes des ruminants
Lonneux, J. F.; Losson, Bertrand ULg

in Point Vétérinaire (1998), 188

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See detailTriose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus. Kinetic and structural properties
Alvarez, Marco; Zeelen, Johan Ph; Mainfroid, Véronique et al

in Journal of Biological Chemistry (1998), 273(4), 2199-206

The purification and characterization of triose-phosphate isomerase from the psychrophilic bacterium Vibrio marinus (vTIM) is described. Crystal structures of the vTIM-sulfate complex and the vTIM-2 ... [more ▼]

The purification and characterization of triose-phosphate isomerase from the psychrophilic bacterium Vibrio marinus (vTIM) is described. Crystal structures of the vTIM-sulfate complex and the vTIM-2-phosphoglycolate complex (at a 2.7-A resolution) are also presented. The optimal growth temperature of Vibrio marinus is 15 degrees C. Stability studies show that vTIM is an unstable protein with a half-life of only 10 min at 25 degrees C. The vTIM sequence is most closely related to the sequence of Escherichia coli TIM (eTIM) (66% identity), and several unique structural features described for eTIM are also seen in vTIM, but eTIM is considerably more stable. The Td values of vTIM and eTIM, determined by calorimetric studies, are 41 and 54 degrees C, respectively. Amino acid sequence comparison reveals that vTIM has an alanine in loop 8 (at position 238), whereas all other TIM sequences known to date have a serine. The vTIM mutant A238S was produced and characterized. Compared with wild type, the catalytic efficiency of the A238S mutant is somewhat reduced, and its stability is considerably increased. [less ▲]

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See detailContribution Of The Hydrophobicity Gradient Of An Amphipathic Peptide To Its Mode Of Association With Lipids
Perez-Mendez, O.; Vanloo, B.; Decout, A. et al

in European Journal of Biochemistry (1998), 256(3), 570-9

A class of peptides that associate with lipids, known as oblique-orientated peptides, was recently described [Brasseur R., Pillot, T., Lins, L., Vandekerckhove, J. & Rosseneu, M. (1997) Trends Biochem ... [more ▼]

A class of peptides that associate with lipids, known as oblique-orientated peptides, was recently described [Brasseur R., Pillot, T., Lins, L., Vandekerckhove, J. & Rosseneu, M. (1997) Trends Biochem. Sci. 22, 167-171]. Due to an asymmetric distribution of hydrophobic residues along the axis of the alpha-helix, such peptides adopt an oblique orientation which can destabilise membranes or lipid cores. Variants of these oblique peptides, designed to have an homogeneous distribution of hydrophobic and hydrophilic residues along the helical axis, are classified as regular amphipathic peptides. These peptides are expected to lie parallel to the polar/apolar interface with their hydrophobic residues directed towards the apolar and their hydrophilic residues towards the polar phase. An hydrophobic, oblique-orientated peptide was identified at residues 56-68 in the sequence of the lecithin-cholesterol acyltransferase (LCAT), enzyme. This peptide is predicted to penetrate a lipid bilayer at an angle of 40 degrees through its more hydrophobic C-terminal end and thereby induce the destabilisation of a membrane or a lipid core. The LCAT-(56-68) wild-type peptide was synthesised together with the LCAT-(56-68, 0 degrees) variant, in which the hydrophobicity gradient was abolished through residue permutations. In two other variants, designed to keep their oblique orientation, the W61 residue was shifted either towards the more hydrophilic N-terminal at residue 57, or to position 68 at the hydrophobic C-terminal end of the peptide. Peptide-induced vesicle fusion was demonstrated by fluorescence measurements using pyrene-labeled vesicles and by monitoring of vesicle size by gel filtration. The interaction between peptides and lipids was monitored by measurement of the intrinsic tryptophan fluorescence emission of the peptides. Fluorescence polarisation measurements, using diphenyl hexatriene, were carried out to follow changes in the lipid fluidity. The LCAT-(56-68) wild-type peptide and the two oblique variants, induced fusion of unilamellar dimyristoylglycerophosphocholine vesicles. Tryptophan fluorescence emission measurements showed a 12-14 nm blue shift upon addition of the wild-type peptide and of the W61-->68 variant to lipids, whereas the fluorescence of the W61-->57 variant did not change significantly. This observation supports the insertion of the more hydrophobic C-terminal residues into the lipid phase, as predicted by the theoretical calculations. In contrast, the 0 degrees variant peptide had no fusogenic activity, and it associated with lipids to form small discoidal lipid/peptide complexes. The phospholipid transition temperature was decreased after addition of the wild-type, the W61-->68 and W61-->57 fusogenic peptides, whereas the opposite effect was observed with the 0 degrees variant. The behaviour of the wild-type and variant LCAT-(56-68) peptides stresses the contribution of the hydrophobicity gradient along the axis of an amphipathic peptide to the mode of association of this peptide with lipids. This parameter consequently influences the structural modifications occurring to lipids upon association with amphipathic peptides. [less ▲]

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See detailEvaluation de l'impact du cours d'éducation par la technologie
Hubert, Sylviane; Denis, Brigitte ULg

in Informations pédagogiques (1998), 40

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See detailAminoglycoside 6 '-N-Acetyltransferase Variants Of The Ib Type With Altered Substrate Profile In Clinical Isolates Of Enterobacter Cloacae And Citrobacter Freundii
Casin, I.; Bordon, F.; Bertin, P. et al

in Antimicrobial Agents and Chemotherapy (1998), 42(2), 209-15

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6'-N acetyltransferase type II [AAC(6 ... [more ▼]

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6'-N acetyltransferase type II [AAC(6')-II] production, which conferred reduced susceptibility to gentamicin but not to amikacin or isepamicin. Aminoglycoside acetyltransferase assays suggested the synthesis in the three strains of an AAC(6') which acetylated amikacin practically as well as it acetylated gentamicin in vitro. Both compounds, however, as well as isepamicin, retained good bactericidal activity against the three strains. The aac genes were borne by conjugative plasmids (pLMM562 and pLMM564 of ca. 100 kb and pLMM563 of ca. 20 kb). By PCR mapping and nucleotide sequence analysis, an aac(6')-Ib gene was found in each strain upstream of an ant(3")-I gene in a sulI-type integron. The size of the AAC(6')-Ib variant encoded by pLMM562 and pLMM564, AAC(6')-Ib7, was deduced to be 184 (or 177) amino acids long, whereas in pLMM563 a 21-bp duplication allowing the recruitment of a start codon resulted in the translation of a variant, AAC(6')-Ib8, of 196 amino acids, in agreement with size estimates obtained by Western blot analysis. Both variants had at position 119 a serine instead of the leucine typical for the AAC(6')-Ib variants conferring resistance to amikacin. By using methods that predict the secondary structure, these two amino acids appear to condition an alpha-helical structure within a putative aminoglycoside binding domain of AAC(6')-Ib variants. [less ▲]

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See detailDevelopment of a non-surfactant parenteral formulation of miconazole by the use of cyclodextrins
Piel, Géraldine ULg; Evrard, Brigitte ULg; Fillet, Marianne ULg et al

in International Journal of Pharmaceutics (1998), 169

Miconazole is an antimycotic drug exhibiting a very poor water solubility (B1.03 mg:ml). It has been shown that cyclodextrins (CDs) are able to form inclusion complexes with miconazole and that they are ... [more ▼]

Miconazole is an antimycotic drug exhibiting a very poor water solubility (B1.03 mg:ml). It has been shown that cyclodextrins (CDs) are able to form inclusion complexes with miconazole and that they are able to increase its aqueous solubility. Miconazole is a weak base whose solubility depends of the pH. The purpose of this study was to investigate the influence of both CDs and different acids on the solubility of miconazole. It was found that a synergistic effect existed between CDs and different acids. The combination of hydroxypropyl-bCD (HP-bCD) (100 mM) or sulfobutylether 7-bCD (SBE7-bCD) (50 mM) and lactic acid (50 mM) allowed to dissolve more than 10 mg of miconazole per ml. NMR studies confirmed the formation of an inclusion complex miconazole–CD in an acidic medium. It was also shown by the NMR studies that the complex formed was a 1:1 complex. These results demonstrate that it is possible to develop a parenteral aqueous solution of miconazole without surfactant. [less ▲]

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See detailEnhanced Efficiency Of A Targeted Fusogenic Peptide
Decout, A.; Labeur, C.; Goethals, M. et al

in Biochimica et Biophysica Acta-Biomembranes (1998), 1372(1), 102-16

Membrane targeting was investigated as a potential strategy to increase the fusogenic activity of an isolated fusion peptide. This was achieved by coupling the fusogenic carboxy-terminal part of the beta ... [more ▼]

Membrane targeting was investigated as a potential strategy to increase the fusogenic activity of an isolated fusion peptide. This was achieved by coupling the fusogenic carboxy-terminal part of the beta-amyloid peptide (Abeta, amino acids 29-40), involved in Alzheimer's disease, to a positively charged peptide (PIP2-binding peptide, PBP) interacting specifically with a naturally occurring negatively charged phospholipid, phosphatidylinositol 4, 5-bisphosphate (PIP2). Peptide-induced vesicle fusion was spectroscopically evidenced by: (i) mixing of membrane lipids, (ii) mixing of aqueous vesicular contents, and (iii) an irreversible increase in vesicle size, at concentrations five to six times lower than the Abeta(29-40) peptide. In contrast, at these concentrations the PBP-Abeta(29-40) peptide did not display any significant activity on neutral vesicles, indicating that negatively charged phospholipids included as targets in the membranes, are required to compensate for the lower hydrophobicity of this peptide. When the alpha-helical structure of the chimeric peptide was induced by dissolving it in trifluoroethanol, an increase of the fusogenic potential of the peptide was observed, supporting the hypothesis that the alpha-helical conformation of the peptide is crucial to trigger the lipid-peptide interaction. The specificity of the interaction between PIP2 and the PBP moiety, was shown by the less efficient targeting of the chimeric peptide to membranes charged with phosphatidylserine. These data thus demonstrate that the specific properties of both the Abeta(29-40) and the PBP peptide are conserved in the chimeric peptide, and that a synergetic effect is reached through chemical linkage of these two fragments. [less ▲]

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See detailInterpretation of behavioural reactions of sheep towards fear-eliciting situations.
Vandenheede, Marc ULg; Bouissou, Marie-France; Picard, M.

in Applied Animal Behaviour Science (1998), 58

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See detailLes annonces de librairie dans l'Elite des nouvelles (1717-1721)
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1998), 282

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See detailLes Miracles de saint Quirin de Malmedy, un livret médiéval au coeur du XVIe siècle
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1998), CLXIV

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See detailPharmaco-economie des medicaments hypolipidemiants: analyse des facteurs influencant le rapport cout/efficacite.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(5), 270-5

The demonstration that stains reduce the risk of cardiovascular diseases, in both secondary and primary prevention trials, led to the recent publication of sophisticated pharmaco-economical studies. A lot ... [more ▼]

The demonstration that stains reduce the risk of cardiovascular diseases, in both secondary and primary prevention trials, led to the recent publication of sophisticated pharmaco-economical studies. A lot of factors may influence the cost-effectiveness ratio of the pharmacological intervention, especially the mode of calculation of various costs, the initial level of cardiovascular risk of the patients and the medico-economical particularities of each country. What so ever, available studies appear to justify the use of statins in secondary prevention, i.e. in coronary patients, even those with only a moderate hypercholesterolaemia, and, in primary prevention, i.e in hypercholesterolaemia individuals with obvious high risk of cardiovascular disease. [less ▲]

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See detailAre we close to decyphering the timer's enigma ?
Richelle, Marc ULg; Lejeune, Helga ULg

in Current Psychology of Cognition [=CPC] = Cahiers de Psychologie Cognitive [=CPC] (1998), 17(4-5), 867-879

Among the theoretical models, Gibbon and Chruch's temporal information processing model is by far the most popular explanatory device in the domain of animal timing, and timing recorded using the peak ... [more ▼]

Among the theoretical models, Gibbon and Chruch's temporal information processing model is by far the most popular explanatory device in the domain of animal timing, and timing recorded using the peak procedure is considered to reflect pure cognitive time. Neuropharmacological breakthroughs suggest that diferent neurotransmitter systems subserve different functions or stages, as specified by the temporal information proccessing model. Cerebral activations correlated to timing performance have been described in humans. however, several questions remain unanswered, particularly those regarding the specificity of the neutral and biochemical correlates of timing performance. At the behavioral level, the dynamic aspects of timing, as well as timing patterns which cannot be explained within the framework of existing models, deserve a renewal of interest. [less ▲]

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See detailEvaluation of the effect of two training regimes on the resumption of the ovarian activity by analysis of faecal 20 alpha-hydroxyprogesterone in trotter mares
Messina, Mariella; Prandi, Alberto; Bolelli, G. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2

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See detailBasic issues in the finite element simulation of extended endplate connections
Bursi, O.; Jaspart, Jean-Pierre ULg

in Computers & Structures (1998), 69

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See detailComment je traite... un patient diabetique de type 2: le projet "DREAM" pour une meilleure collaboration medecin generaliste-medecin specialiste. Diabetes Reinforcement of Adequate Management.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(2), 58-62

Type 2 diabetes is an important public health problem because of its high prevalence and morbidity rate which both are associated with a considerable social and human cost. The general practitioner should ... [more ▼]

Type 2 diabetes is an important public health problem because of its high prevalence and morbidity rate which both are associated with a considerable social and human cost. The general practitioner should play a central role in the management of patients with type 2 diabetes and try to meet the therapeutic objectives. Main goals include reinforcement of early diagnosis, by a better screening of individuals at risk for type 2 diabetes, achievement of a good glycaemic control, through an optimized antidiabetic treatment, correction of associated risk factors as well as detection and treatment of disease complications. DREAM ("Diabetes Reinforcement of Adequate Management") is a pilot project which started in Liege area end 1997 for at least 2 years. It aims at improving the management of type 2 diabetic patients through a better free collaboration between general practitioners and diabetologists and the adhesion to an optimized therapeutic strategy. This ambitious project benefits from the valuable support of three pharmaceutical companies. [less ▲]

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See detailLong-range Coulomb interaction in ZrO2
Detraux, F.; Ghosez, Philippe ULg; Gonze, X.

in Physical Review Letters (1998), 81(15), 3297-3297

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See detailEstimation of dominance variance in purebred Yorkshire swine
Culbertson, M. S.; Mabry, J. W.; Misztal, I. et al

in Journal of Animal Science (1998), 76(2), 448-451

We used 179,485 Yorkshire reproductive and 239,354 Yorkshire growth records to estimate additive and dominance variances by Method Fraktur R. Estimates were obtained for number born alive (NBA), 21-d ... [more ▼]

We used 179,485 Yorkshire reproductive and 239,354 Yorkshire growth records to estimate additive and dominance variances by Method Fraktur R. Estimates were obtained for number born alive (NBA), 21-d litter weight (LWT), days to 104.5 kg (DAYS), and backfat at 104.5 kg (BF). The single-trait models for NBA and LWT included the fixed effects of contemporary group and regression on inbreeding percentage and the random effects mate within contemporary group, animal permanent environment, animal additive, and parental dominance. The single-trait models for DAYS and BF included the fixed effects of contemporary group, sex, and regression on inbreeding percentage and the random effects litter of birth, dam permanent environment, animal additive, and parental dominance. Final estimates were obtained from six samples for each trait. Regression coefficients for 10% inbreeding were found to be -.23 for NBA, -.52 kg for LWT, 2.1 d for DAYS, and 0 mm for BF. Estimates of additive and dominance variances expressed as a percentage of phenotypic variances were, respectively, 8.8 +/- .5 and 2.2 +/- .7 for NBA, 8.1 +/- 1.1 and 6.3 +/- .9 for LWT, 33.2 +/- .4 and 10.3 +/- 1.5 for DAYS, and 43.6 +/- .9 and 4.8 +/- .7 for BF. The ratio of dominance to additive variances ranged from .78 to .11. [less ▲]

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See detailEvaluation of the sensitivity of the terminal deoxynucleotidyl transferase-immunogold technique on Balbani ring genes.
Thiry, Marc ULg; Daneholt, B.

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1998), 46(3), 345-51

Recently, we developed the terminal deoxynucleotidyl transferase (TdT)-immunogold technique for in situ detection of DNA molecules. In this study the potential value and the limitations of the method were ... [more ▼]

Recently, we developed the terminal deoxynucleotidyl transferase (TdT)-immunogold technique for in situ detection of DNA molecules. In this study the potential value and the limitations of the method were evaluated using the giant polytene chromosomes from Chironomus tentans salivary glands. Emphasis was put on the Balbiani rings (BRs), specialized chromosomal sites with exceptionally intense synthesis of large mRNA molecules. Immunolabeling was recorded not only over the bands and interbands of the polytene chromosomes but also over the BR structures. In the BRs, gold particles were present over segments of active transcription units, each with a central chromatin axis and a number of growing RNP products attached to the axis. One third of the transversely sectioned transcription units showed labeling in the central parts, i.e., where the unfolded chromatin axis is located, whereas the growing RNP fibers remained unlabeled. The absence of labeling of the RNP fibers is not likely to be due to lack of accessibility, because anti-RNA antibodies readily decorated the RNP fibers. The nuclear sap and cytoplasm displayed no significant label. These results clearly indicate that the TdT-immunogold technique is specific for DNA and detects not only DNA in compacted chromatin but also fully extended DNA. Its ability to efficiently label a single DNA molecule demonstrates the method's very high sensitivity. [less ▲]

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See detailAtypical metabolisms and biochemical cycles imposing the cancerous state on plant cells
Gaspar, Thomas ULg; Bisbis, Badia; Kevers, Claire ULg et al

in Plant Growth Regulation (1998), 24(2), 135-144

The biological, morphological and biochemical characteristics which define plant cancer cells at the end of a neoplasic progression in the absence of pathogens and which distinguish them from tumorous ... [more ▼]

The biological, morphological and biochemical characteristics which define plant cancer cells at the end of a neoplasic progression in the absence of pathogens and which distinguish them from tumorous cells are summarized. Such plant cancer cells have in common with animal cancer cells many metabolic disturbances. The present paper reviews the biochemical changes in nitrogen, carbon, sugar and heme metabolisms which contribute to polyamine (PAs) accumulation. It indicates how these changes are interconnected and even form between each other biochemical cycles which likely maintain these cells in their irreversible state. The role of these cycles in the maintenance of such cells under a probable permanent oxidative stress is debated. [less ▲]

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See detailAnalyse de l'enseignement des activités physiques et sportives dans la perspective d'un traitement différencié des élèves de l'enseignement primaire
Piéron, Maurice ULg; Ledent, Maryse; Delfosse, Catherine et al

in Revue de l'Education Physique (1998), 38(1), 11-24

Afin de recueillir une image valide tu traitement différencié des élèves dans des leçons d'éducation physique, il est primordial de proposer une approche multidimensionnelle, prenant comme cible les ... [more ▼]

Afin de recueillir une image valide tu traitement différencié des élèves dans des leçons d'éducation physique, il est primordial de proposer une approche multidimensionnelle, prenant comme cible les différents acteurs du processus édagogique, à la fois les enseignants et les élèves. Par ailleurs, deux types d'informations devraient être récoltés afin de rendre compte de la réalité de la relation pédagogique: celles qui concernent les comportements et actions concrètes et celles relevant des valeurs, attitudes, perceptions et mécanismes de prise de décision. Les premières reposent sur l'observation alors que les secondes exigent l'interrogation des sujets. [less ▲]

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See detailPeroxidase activity, ethylene production, lignification and growth limitation in shoots of a nonrooting mutant of tobacco
Faivre-Rampant, Odile; Kevers, Claire ULg; Bellini, Catherine et al

in Plant Physiology & Biochemistry (1998), 36(12), 873-877

The rooting recalcitrant rac Nicotiana tabacum cv Xanthi mutant has been multiplied in vitro under the form of shoots in parallel to wild-type. rac Shoots grew at a lower rate and did not root whatever ... [more ▼]

The rooting recalcitrant rac Nicotiana tabacum cv Xanthi mutant has been multiplied in vitro under the form of shoots in parallel to wild-type. rac Shoots grew at a lower rate and did not root whatever the treatments when compared to those of wild-type shoots. They were characterized by a higher lignin level, a higher total specific peroxidase activity with higher activity of both acidic and basic isoperoxidases (although missing and supernumerary isoenzymes were observed), and higher ethylene production. These observations might be causally related to growth inhibitions as similar incidences have been noted in different stress-induced growth limitation, through cell wall rigidification and auxin catabolism. The relationship between these aspects and rooting recalcitrance remains to be explored. (C) Elsevier, Paris. [less ▲]

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See detailPharma-clinics. Le dopage a l'erythropoietine ou l'utilisation detournee des progres therapeutiques.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(8), 499-502

Sport performance depends on the capacity of oxygen transport to the exercising skeletal muscles. Performance may be increased thanks to an haematocrit augmentation, either by training in high altitude ... [more ▼]

Sport performance depends on the capacity of oxygen transport to the exercising skeletal muscles. Performance may be increased thanks to an haematocrit augmentation, either by training in high altitude, using blood transfusions, or injecting erythropoietin (Epo). Since the synthesis of Epo by bioengineering, doping with recombinant human Epo has become popular in sports in general, and in cycling in particular. This new kind of doping might have been responsible for several sudden deaths in young athletes, essentially in racing cyclists. Until now, such a doping is hardly to be detected. However, it should deserve careful consideration from both public health authorities and sports communities in order to stop what could become a real plague. [less ▲]

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See detailObesity and nutrition in children. The Belgian Luxembourg Child Study IV.
Guillaume, Michèle ULg; Lapidus, L.; Lambert, A.

in European Journal of Clinical Nutrition (1998), 52(5), 323-8

OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium ... [more ▼]

OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium. Subjects: One thousand and twenty-eight boys and girls in age strata 6-8, 8-10 and 10-12 y, comprising 70.3% of primary cohort. METHODS: Examinations included anthropometric measurements and questionnaires covering familial, socioeconomic and psychosocial factors. A three day dietary record was obtained in 955 children. This was analysed in relation to the anthropometric data. RESULTS: In comparison with similar studies from other regions and recommended allowances, the intakes of total energy, fat, particularly saturated fat and cholesterol, were high, while consumption of carbohydrate and fiber was low, as well as the polyunsaturated/saturated ratio of fat. Total energy intake showed no or weakly significant correlations with anthropometric factors. However, total fat (P=0.045) and saturated fat (P=0.0005) intake showed consistent positive correlations with body mass index (BMI, kg/m2) and skinfold thickness, with corresponding negative relationships to carbohydrate intake (P=0.034) in boys. Such relationships were also found when calculated as energy density. These associations were not statistically significant in girls. The high fat, low carbohydrate pattern of the nutritional status seemed to be more pronounced in families where the father had a low level of education (lipids, boys, P=0.0007), and where both parents were obese (saturated fat, boys, P=0.023), suggesting involvement of socioeconomic and familial factors. CONCLUSION: The lack of correlation between factors indicating obesity and total energy intake suggests that the positive energy balance causing obesity is due mainly to a low energy output. However, since energy intake measurements are imprecise, overeating can not be excluded, particularly since elevated consumption of food with high contents of fat, found in these children seems to be poorly regulated. [less ▲]

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See detailPreserved artificial grammar learning in Parkinson's disease
Meulemans, Thierry ULg; Peigneux, Philippe ULg; Van der Linden, Martial ULg

in Brain & Cognition (1998), 37(1), 109-112

Parkinson's disease (PD) patients and matched control subjects were compared in an artificial grammar learning task. The test strings were constructed in such a way that grammaticality judgments could not ... [more ▼]

Parkinson's disease (PD) patients and matched control subjects were compared in an artificial grammar learning task. The test strings were constructed in such a way that grammaticality judgments could not be based on some superficial features of the learning strings: the grammatical and nongrammatical test strings did not differ according to different measures of chunk strength (based on the frequency with which their bigrams and trigrams appear in the learning strings). Results show that PD patients and controls performed at the same level during the first presentation of the test strings series, which suggests that the striatum is not (crucially) implicated in the ability to abstract rules implicitly from exemplars generated by a finite-state grammar. However, and contrary to control subjects, the classification performance of PD patients was at chance during the second presentation of the test strings. We argue that this latter result could be the consequence of the attentional deficit of PD patients. [less ▲]

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See detailExtracellular enveloped vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope
Vanderplasschen, Alain ULg; Mathew, E.; Hollinshead, M. et al

in Proceedings of the National Academy of Sciences of the United States of America (1998), 95

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See detailPharma-clinics. Le medicament du mois. L'atorvastatine (Lipitor).
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(6), 374-7

Atorvastatin, commercialized by the pharmaceutical companies Parke-Davis and Pfizer under the trade name Lipitor, is a new statin acting as a potent hypolipidaemic drug. By inhibiting HMG-CoA reductase ... [more ▼]

Atorvastatin, commercialized by the pharmaceutical companies Parke-Davis and Pfizer under the trade name Lipitor, is a new statin acting as a potent hypolipidaemic drug. By inhibiting HMG-CoA reductase, the key-enzyme of cellular synthesis of cholesterol, it increases the expression of LDL receptors and promotes the hepatic extraction of circulating LDL. It has a more potent action than other available statins, both on LDL cholesterol and triglyceride levels. Atorvastatin is indicated, after diet failure, in the treatment of primary hypercholesterolaemia or combined hyperlipidaemia. Lipitor is available as tablets of 10 and 20 mg. The usual doses is 10 mg once a day, to be increased up to 20 mg/day if necessary. In rare severe cases, the doses may be increased up to 80 mg/day. [less ▲]

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See detailLes pucerons sont-ils résistants aux insecticides en Belgique ?
Francis, Frédéric ULg; Haubruge, Eric ULg; Gaspar, C.

in Parasitica (1998), 54(4), 151-161

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See detailIGF-I and their binding proteins in growing horses.
Gerin, Daniele; Messina, Mariella; Renaville, Robert ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 34

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See detailPharma-Clinics. Le medicament du mois. La ranitidine bismuth citrate (Pylorid).
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(1), 41-4

Ranitidine bismuth citrate (Pylorid, Glaxo-Wellcome) is a novel salt of ranitidine which provides a unique combination of properties: inhibition of secretion of gastric acid by competitive antagonism of ... [more ▼]

Ranitidine bismuth citrate (Pylorid, Glaxo-Wellcome) is a novel salt of ranitidine which provides a unique combination of properties: inhibition of secretion of gastric acid by competitive antagonism of the action of histamine at the histamine H2-receptor on the gastric parietal cell, mucosal protective effects and anti-Helicobacter pylori action. Ranitidine bismuth citrate provides effective healing and symptom relief, both in duodenal ulcer disease and in gastric ulcer disease. When coprescribed with certain antibiotics (clarithromycin alone or combined with amoxicillin or nitro-imidazole), it heals ulcers, eradicates Helicobacter pylori and prevents recurrence of the disease. Several clinical studies demonstrated that ranitidine bismuth citrate is well-tolerated and has quite similar efficacy as proton pump inhibitors. [less ▲]

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See detailBaudelaire, analyse textuelle : "Les Hiboux"
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1998)

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See detailLettres américaines de Georges Simenon à André Gide (1945-1950)
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (1998), (10), 11-51

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See detailL'apport des banques de données biogéographiques à la conservation de l'entomofaune
Lebrun, Philippe; Dufrêne, Marc ULg

in Parcs & Réserves (1998), 53

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See detailSelf-consistent approximations in relativistic plasmas: Quasiparticle analysis of the thermodynamic properties
Vanderheyden, Benoît ULg; Baym, G.

in Journal of Statistical Physics (1998), 93(3-4), 843-861

We generalize the concept of conserving, Phi-derivable, approximations to relativistic field theories. Treating the interaction field as a dynamical degree of freedom, we derive the thermodynamic ... [more ▼]

We generalize the concept of conserving, Phi-derivable, approximations to relativistic field theories. Treating the interaction field as a dynamical degree of freedom, we derive the thermodynamic potential in terms of fully dressed propagators, an approach which allows us to resolve the entropy of a relativistic plasma into contributions from its interacting elementary excitations. We illustrate the derivation for a hot relativistic system governed by electromagnetic interactions. [less ▲]

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See detailEffect of Ketoprofen on Paf-Induced Bovine Platelet Aggregation
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Journal (1998), 155(2), 201-203

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See detailCompensatory growth in Belgian Blue bulls previously maintained at two growing rates on pasture: animal performance and meat characteristics
Hornick, Jean-Luc ULg; Raskin, Pascale; Clinquart, Antoine ULg et al

in Animal Science (1998), 67(3), 427-434

A comparison was made between finishing systems with Belgian Blue bulls of the double-muscle type, in order to assess the response in terms of compensatory growth when bulls were grazed at a high stocking ... [more ▼]

A comparison was made between finishing systems with Belgian Blue bulls of the double-muscle type, in order to assess the response in terms of compensatory growth when bulls were grazed at a high stocking rate. Two groups of 8 bulls (256.5 kg liveweight) were grazed on Lolium perenne and Trifolium repens pasture during an initial period of 135 days (period I). One group grazed at a stocking rate of 6/ha allowing for normal growth at pasture (NGP); the other group grazed at a stocking rate of 10/ha (low growth at pasture, LGP). Both groups were then finished indoors (period II) with a concentrate based on dried sugarbeet pulp. Eight control bulls were also finished indoors on the concentrate diet during periods I and II (CG). Bulls were slaughtered according to a similar finishing state. Liveweight gains were 1.47, 1.10 and 0.52 kg daily (P<0.001) during period I in CG, NGP and LGP groups respectively. Corresponding liveweight gains during period II were 1.22, 1.37 and 1.50 kg daily. The LGP group had lower feed conversion ratios, slaughter weights (P<0.05) and dressing proportions (P<0.01). The meat from the grazed bulls had lower cooking losses (P<0.05) and tended to have lower drip losses and higher tenderness. It also had a higher cholesterol (P<0.05) content. Large differences were observed in the fatty acid composition according to fat location (subcutaneous, intermuscular or intramuscular). The proportions of mono and polyunsaturated acids increased in the adipose tissue of those previously grazed. [less ▲]

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See detailHeavy-flavour pentaquarks in a chiral constituent quark model
Genovese, M.; Richard, J. M.; Stancu, Floarea ULg et al

in Physics Letters B (1998), B425

Within the chiral constituent quark model of Glozman and Riska, we discuss the stability of heavy pentaquarks, i.e. hadrons containing four light quarks and a heavy antiquark. The spin-dependent part of ... [more ▼]

Within the chiral constituent quark model of Glozman and Riska, we discuss the stability of heavy pentaquarks, i.e. hadrons containing four light quarks and a heavy antiquark. The spin-dependent part of the Hamiltonian is dominated by the short-range part of the Goldstone-boson-exchange interaction. We find that these systems are not bound, having an energy above the lowest dissociation threshold into a baryon and a meson. [less ▲]

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See detailLe cartilage articulaire peut-il se régénérer ? (1ère partie)
Henrotin, Yves ULg; Reginster, Jean-Yves ULg

in Le Généraliste (1998), 414

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See detailHigh-frequency oscillatory ventilation in neonatal RDS:initial volume optimization an respiratory mechanics
Masendu, Kalenga; Battisti, Oreste ULg; Bertrand, jean-marie et al

in Journal of Applied Physiology (1998), 84

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See detailBiorthogonal wavelets in H-m(R)
Bastin, Françoise ULg; Boigelot, Christine

in Journal Of Fourier Analysis And Applications (1998), 4(6), 749-768

This article is concerned with constructions of biorthogonal basis of compactly supported wavelets in Sobolev spaces of integer order. Using techniques of [1] and [2], the results presented here ... [more ▼]

This article is concerned with constructions of biorthogonal basis of compactly supported wavelets in Sobolev spaces of integer order. Using techniques of [1] and [2], the results presented here generalize to Sobolev spaces some constructions of Cohen et al. [7] and Chui and Wang [5] established in L-2(R). [less ▲]

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See detailValidation of impulse oscillometry in Friesian and Blue Belgian calves with respect to changes in extrathoracic upper airway resistance
Reinhold, Petra; Smith, H.-J.; Close, Roland et al

in Research in Veterinary Science (1998), 65

Impulse oscillometry (IOS) was compared with conventional pulmonary function techniques (using oesophageal balloon and airflow measurements). Healthy Friesian (FR) and Blue Belgian (BB) calves were ... [more ▼]

Impulse oscillometry (IOS) was compared with conventional pulmonary function techniques (using oesophageal balloon and airflow measurements). Healthy Friesian (FR) and Blue Belgian (BB) calves were examined in different conditions of extrathoracic airway resistance (physiological and vertical head position). Higher resistance values were detected in BB calves compared with FR calves with both conventional and forced oscillation techniques in both head positions. Upper airway narrowing was characterised by increasing resistance values without changes in frequency dependence. Measuring input impedance in animals using a face mask, a considerable capacitive shunt of the upper airways (including the capacitive components of the mask) has to be taken into account. Even if the absolute value of this capacitive component is constant, its influence on the measurement results increases with growing frequency and with an increase in upper airway resistance. In conclusion, (1) impulse oscillometry is sensitive to upper airway resistance changes and (2) face mask capacitance is important and has frequency dependent effects on the respiratory impedance. [less ▲]

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See detailLa Convention de Bruxelles
Boularbah, Hakim ULg; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (1998)

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See detailCompte-rendu de l'article de Paul Wathelet, Rhésos ou la quête de l'immortalité
Renaud, Jean-Michel ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1998), Supplément 6

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See detailTextural properties of pressure-induced gels of food proteins obtained under different temperatures including zero
Dumoulin, Mireille ULg; Osawa, S.; Hayashi, Rikimaru

in Journal of Food Science (1998), 63

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See detailLes chimioradiothérapies dans les cancers du col utérin
Maingon, P; COUCKE, Philippe ULg; Haie-Meder, C et al

in Cancer Radiotherapie (1998), 2

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See detailAssessment of proliferative and colony-forming capacity after successive in vitro divisions of single human CD34+ cells initially isolated in G0.
GOTHOT, André ULg; Pyatt, R.; McMahel, J. et al

in Experimental hematology (1998), 26(7), 562-70

Exit of primitive hematopoietic progenitor cells (HPCs) from the G0 phase of the cell cycle in response to in vitro cytokine stimulation is a limiting step in successful ex vivo expansion. Simultaneous ... [more ▼]

Exit of primitive hematopoietic progenitor cells (HPCs) from the G0 phase of the cell cycle in response to in vitro cytokine stimulation is a limiting step in successful ex vivo expansion. Simultaneous DNA/RNA staining with Hoechst 33342 and pyronin Y was used to separate human bone marrow CD34+ cells residing in G0 (G0CD34+) from those cycling in G1 and S/G2+M. Compared with CD34+ cells isolated in G1, G0CD34+ cells were characterized by a delayed response to cytokine stimulation and were enriched for long-term hematopoietic culture-initiating cells. We next compared the activation kinetics of individually sorted G0CD34+ cells stimulated with stem cell factor (SCF), flt3-ligand (FL), or interleukin-3 (IL-3) as single factors. In a novel clonal proliferation assay, the functional status of cells that had remained quiescent after an initial 7-day period and of those that had completed successive division cycles under each of these three factors was evaluated by assessment of subsequent proliferative capacity and maintenance of colony-forming cell precursor (pre-CFC) activity. All three cytokines were equally able to support the survival of primitive HPCs in the absence of cell division. Cells that did not respond to any cytokine stimulation for 7 days retained higher proliferative and pre-CFC activities than dividing cells. The hematopoietic function of cells that divided in response to SCF, FL, or IL-3 decreased after each division cycle. However, G0CD34+ cells displayed a heterogeneous response pattern to cytokine stimulation whereby SCF appeared to have a superior ability to promote the cycling of cells with high proliferative and pre-CFC activities. These results indicate that HPCs reside in opposing hierarchies of hematopoietic potential and responsiveness to cytokine stimulation. The data also begin to indicate relationships between cellular division in response to different stimuli and maintenance of hematopoietic function. [less ▲]

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See detailA new time domain to estimate windkessel parameters of pulmonary circulation
LAMBERMONT, Bernard ULg; GERARDP; POTTY, P et al

in American Journal of Respiratory & Critical Care Medicine (1998), 157

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See detailThe Perturbed Generalized Proximal Point Algorithm
Alexandre, Patrick; Nguyen, Van Hien; Tossings, Patricia ULg

in RAIRO : Modélisation Mathématique et Analyse Numérique (Mathematical Modelling and Numerical Analysis) (1998), 32(2), 223-253

During the last years, different modifications were introduced in the proximal point algorithm devloped by R.T. Rockafellar for searching a zero of a maximal monotone operator on a real Hilbert space. We ... [more ▼]

During the last years, different modifications were introduced in the proximal point algorithm devloped by R.T. Rockafellar for searching a zero of a maximal monotone operator on a real Hilbert space. We combine these modifications to get a new version of this algorithm. We take simultaneously into account a variable metric, a perturbation and a kind of relaxation. Our work takes place in the context of the variational convergence theory. [less ▲]

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See detailPleidooi voor en civilistische aanpak van overeenkomsten gesloten in het kader van overheidsopdrachten
Boularbah, Hakim ULg; Ronse, K.

in Chroniques de Droit Public = Publiekrechtelijke Kronieken (1998)

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See detailLe colza en Belgique. Production et recherche.
Cartrisse, Christine; Wathelet, Jean-Paul ULg

in Bulletin du GCIRC (1998), 15

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See detailLatinitas-Peregrinitas. Purisme et nationalisme linguistique chez les grammairiens latins
Rochette, Bruno ULg

in Orbis : Bulletin international de documentation linguistique (1998), 40

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See detailEvidence For The Occurrence Of Endophytic Prokaryotic Contaminants In Micropropogated Plantlets Of Prunus Cerasus Cv. 'Montmorency'
Kamoun, R.; Lepoivre, Philippe ULg; Boxus, P.

in Plant Cell, Tissue & Organ Culture (1998), 52(1-2),

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See detailPrediction Of Epitopes And Production Of Monoclonal Antibodies Against Gastric H,K-Atpase
Irnaten, M.; Gallet, X.; Festy, F. et al

in Protein Engineering (1998), 11(10), 949-55

Monoclonal antibodies (mAbs) were produced against gastric H,K-ATPase using a theoretical and experimental strategy based on prediction of linear epitopes by molecular modelling followed by production of ... [more ▼]

Monoclonal antibodies (mAbs) were produced against gastric H,K-ATPase using a theoretical and experimental strategy based on prediction of linear epitopes by molecular modelling followed by production of anti-peptide antibodies. By analysing the alpha subunit sequence, we predicted several epitopes corresponding to amino acids K519-L533, E543-Y553 and S786-L798 and produced monoclonal antibodies HK519, HK543 and HK786. All three react against gastric H,K-ATPase in RaLISA, immunohistochemistry and Western blots demonstrating that they recognize the native and the SDS-denatured ionic pump and that the epitopes are located at the surface of the native ATPase. Antibody Kd are in the range 6-10x10(-8) M. Monoclonal antibody HK519 is a competitive inhibitor of ATP, in agreement with ATP binding to K519. Neither mAb 543, nor mAb 786 inhibit the ATPase activity. Monoclonal antibody 95111, whose epitope is mapped between residues C529 and E561, competes with mAb HK543 but not with the other two. We suggest that the 95111 epitope is overlapping or very close to the HK543-553 sequence. Induction of E1 conformer by binding FITC to K519 increases the number of mAb 95111 and mAb HK543 epitopes but not that of mAb 786, supporting the fact that the fragment E543-Y553 changes accessibility, maybe during the E1-E2 transconformation. [less ▲]

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See detailEvolution of the Peierls distortion in liquid As xSb 1-x compounds
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Ceolin, R. et al

in Journal of Non-Crystalline Solids (1998), 232-234

The local order in the liquid binary alloy As xSb 1-x (0lesxles1) is studied by short-wavelength (lambda=0.7 Aring) neutron scattering. The coordination number (Z) and the interatomic distances (d) are ... [more ▼]

The local order in the liquid binary alloy As xSb 1-x (0lesxles1) is studied by short-wavelength (lambda=0.7 Aring) neutron scattering. The coordination number (Z) and the interatomic distances (d) are analyzed in terms of the As concentration: Z increases continuously, from a value of 3.5 for pure arsenic to a value of 6.3 for pure antimony, whereas d shows a departure from Vegard's rule. The interatomic distance increases in the range 0.15lesxles1.00 and is almost constant in the range 0.00lesxles0.15. A simple tight-binding model is developed, which indicates that the relevant parameter is the hardness of the core repulsion between the atoms [less ▲]

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See detailInfo-congres. Les lecons de la "United Kingdom Prospective Diabetes Study".
Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (1998), 53(9), 576-8

The United Kingdom Prospective Diabetes Study (UKPDS) is the largest study ever performed in the field of diabetes. It has been carried on in more than 5000 patients with newly diagnosed type 2 diabetes ... [more ▼]

The United Kingdom Prospective Diabetes Study (UKPDS) is the largest study ever performed in the field of diabetes. It has been carried on in more than 5000 patients with newly diagnosed type 2 diabetes and followed during almost 15 years. The main goals of the study were to investigate the effects of improving blood glucose and/or blood pressure control on diabetic complications, and to compare the advantages and inconvenients of the most important pharmacological approaches. The results of the UKPDS have been presented at the last Congress of the European Association for the Study of Diabetes (EASD) in Barcelona, September 10-11, 1998. They essentially showed that improving blood glucose or arterial blood pressure control allows to significantly reduce the incidence of complications associated to diabetes. Best results were observed in individuals in whom treatments of both hyperglycemia and hypertension were intensified. For each risk factor, no threshold has been found so that every reduction in blood glucose or arterial pressure is accompanied by a nearly linear diminution in the incidence of diabetic complications. The type of pharmacological treatment appears to have a less prominent influence, even if metformin appears to exert the most favourable effects in the group of obese patients with type 2 diabetes. [less ▲]

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See detailComparison of spin echo, gradient echo and fat saturation magnetic resonance imaging sequences for imaging the canine elbow
Snaps, Frédéric ULg; Saunders, Jimmy H.; Park, Richard D. et al

in Veterinary Radiology & Ultrasound (1998), 39(6), 518-523

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See detailEffects of Hyperchloremia on Blood Oxygen Binding in Healthy Calves
Cambier, Carole ULg; Detry, B.; Beerens, Dominique ULg et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1998), 85(4), 1267-1272

Three different levels of hyperchloremia were induced in healthy Friesian calves to study the effects of chloride on blood oxygen transport. By infusion, the calves received either 5 ml/kg of 0.9% NaCl ... [more ▼]

Three different levels of hyperchloremia were induced in healthy Friesian calves to study the effects of chloride on blood oxygen transport. By infusion, the calves received either 5 ml/kg of 0.9% NaCl (low-level hyperchloremia; group A), 5 ml/kg of 7.5% NaCl (moderate hyperchloremia; group B), or 7.5 ml/kg of 7.5% NaCl (high-level hyperchloremia; group C). Blood was sampled from the jugular vein and the brachial artery. Chloride concentration, hemoglobin content, arterial and venous pH, PCO2, and PO2 were determined. At each time point (0, 15, 30, 60, and 120 min), the whole blood oxygen equilibrium curve (OEC) was measured under standard conditions. In groups B and C, hyperchloremia was accompanied by a sustained rightward shift of the OEC, as indicated by the significant increase in the standard PO2 at 50% hemoglobin saturation. Infusion of hypertonic saline also induced relative acidosis. The arterial and venous OEC were calculated, with body temperature, pH, and PCO2 values in arterial and venous blood taken into account. The degree of blood desaturation between the arterial and the venous compartments [O2 exchange fraction (OEF%)] and the amount of oxygen released at tissue level by 100 ml of bovine blood (OEF vol%) were calculated from the arterial and venous OEC combined with the PO2 and hemoglobin concentration. The chloride-induced rightward shift of the OEC was reinforced by the relative acidosis, but the altered PO2 values combined with the lower hemoglobin concentration explained the absence of any significant difference in OEF (% and vol%). We conclude that infusion of hypertonic saline induces hyperchloremia and acidemia, which can explain the OEC rightward shift observed in arterial and peripheral venous blood. [less ▲]

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