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See detailPresence of Oestrogen Receptor Type Beta in Human Retina
Munaut, Carine ULg; Lambert, Vincent ULg; Noël, Agnès ULg et al

in British Journal of Ophthalmology (2001), 85(7), 877-82

BACKGROUND/AIMS: Recent studies have demonstrated the existence of two oestrogen receptor subtypes alpha (ORalpha) and beta (ORbeta) with significant differences of expression among organs. Since ... [more ▼]

BACKGROUND/AIMS: Recent studies have demonstrated the existence of two oestrogen receptor subtypes alpha (ORalpha) and beta (ORbeta) with significant differences of expression among organs. Since important pathologies of human eye could be linked to hormonal status, the expression of ORbeta in ocular posterior segment was sought. METHODS: Immunohistochemical localisation of ORbeta and ORalpha protein and detection of OR mRNAs by reverse transcription-polymerase chain reaction (RT-PCR) were performed in macular and extramacular regions of the retina and in the choroid on male and female donors eyes. RESULTS: ORbeta protein was localised in the ganglion cell layer and in the choroid. At the transcriptional level, mRNA for ORbeta and for ORalpha were both present. Local differences in the expression level were observed, however, suggesting the possibility of variation in the ratio of ORalpha v ORbeta. CONCLUSIONS: The coexistence of two oestrogen receptor subtypes in the human ocular posterior segment raises acute questions about their potential physiological role, but offers a perspective for preferential targeting of a specific receptor subtype. [less ▲]

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See detailACTH silent adenoma shrinking under cabergoline.
Petrossians, Patrick ULg; Ronci, N.; Valdes Socin, Hernan Gonzalo ULg et al

in European Journal of Endocrinology (2001), 144(1), 51-57

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non ... [more ▼]

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non-functioning pituitary adenomas. DESIGN: Following the clinical and radiological improvement of a recurrent silent ACTH adenoma in a 77-year-old patient treated with cabergoline (0.5 mg every 2 days for 2 years), in vitro studies of the original tumor were performed. METHODS: The original tumor from the patient was studied by in situ hybridization and dopamine D2 receptor autoradiography. It was compared with four macroprolactinomas and two macroadenomas from patients with Cushing's disease. RESULTS: The D2 receptor mRNA signal of the reported case was intense and of the same order of magnitude as that observed in control prolactinomas. Dopamine D2 receptor autoradiography was twice that of control corticotroph adenomas and was close to that observed in prolactinomas. CONCLUSIONS: This is the first description of an in vivo shrinkage of an ACTH silent adenoma under cabergoline. We demonstrate in vitro, the presence of D2 receptors in the primitive tumor in concentrations similar to those found in control prolactinomas. These results suggest that therapeutic trials with cabergoline might be undertaken in recurring cases of ACTH silent tumors and more generally, non-functioning pituitary adenomas. [less ▲]

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See detailSurvival, gap formation and recovery dynamics in grassland ecosystems exposed to heat extremes: the role of species richness.
Van Peer, L; Nijs, I; Bogaert, Jan ULg et al

in Ecosystems (2001), 4(8), 797-806

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See detailL'élevage du "mouton de case" : aspects techniques, socio-économiques et perspectives d'amélioration au Yatenga (Burkina Faso)
Hamidou, B.; Ilboudo, J.-B.; Ouedraogo, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(4), 201-208

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See detailThe effect of risedronate on hip fracture risk in elderly women with osteoporosis
Bensen, W; Eastell, R; Reginster, Jean-Yves ULg et al

in Journal of Rheumatology (2001), 28(S63), 24

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See detailTraçabilité dans la filière viande. 2. Les marqueurs génétiques.
China, B.; Evrard, V.; Noirfalise, R. et al

in Annales de Médecine Vétérinaire (2001), 145

Afin d’assurer une transparence tout le long de la chaîne de transformation de la viande, il faut disposer d’un système de traçabilité performant. La traçabilité administative montre des limites que ... [more ▼]

Afin d’assurer une transparence tout le long de la chaîne de transformation de la viande, il faut disposer d’un système de traçabilité performant. La traçabilité administative montre des limites que l’utilisation de marqueurs génétiques pourrait surmonter. Le génome de chaque individu possède des différences de séquences, à la base du polymorphisme génétique, dont les marqueurs génétiques sont les témoins. Parmi ceux-ci, deux classes semblent s’imposer en matière de traçabilité : les microsatellites et les polymorphismes simple nucléotide. Les microsatellites sont caractérisés par un degré de polymorphisme important avec de nombreux allèles pour un même locus. De plus, leur détection se fait directement par amplification itérative. Techniquement, le problème se pose lors de la détection simultanée de plusieurs microsatellites où le patron obtenu est difficile à interpréter. Les polymorphismes simple nucléotide sont répresentés par des mutations ponctuelles dans la séquence nucléotidique. Ils sont fréquents, stables, répartis de façon aléatoire et généralement bialléliques. La détection se fait soit par hybridation sur des biopuces, soit par spectrométrie de masse ou par d’autres techniques facilement automatisables. Cette automatisation est nécessaire pour pouvoir tester un grand nombre de polymorphismes simultanément sur un grand nombre d’échantillons, permettant ainsi de diminuer les coûts. L’avantage majeur des polymophismes simple nucléotide est le signal binaire obtenu, son désavantage est le caractère population- spécifique de ce type de marqueur. [less ▲]

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See detailInventaire forestier régional et saisie électronique de données : une synergie prometteuse
Rondeux, Jacques ULg; Cavelier, Tristan

in Revue Forestière Française (2001), LIII(1), 81-87

The work done in connection with any regional or national inventory involves collecting huge amounts of increasingly diversified data. To reduce time lags before such data can be processed, we have ... [more ▼]

The work done in connection with any regional or national inventory involves collecting huge amounts of increasingly diversified data. To reduce time lags before such data can be processed, we have developed an encryption system on a HUSKY personal computer that is highly suitable to the sometimes adverse working conditions encountered in forests. The experiment has turned out to be extremely valuable and the system has been in use since mid-2000 for the purposes of the forest inventory in the Walloon Region. Considerable time savings are thus achieved and a highly elaborate computerised validation process and on-line aid to operators have significantly reduced the frequency of errors. [less ▲]

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See detailExpression of the antiangiogenic factor 16K hPRL in human HCT116 colon cancer cells inhibits tumor growth in Rag1(-/-) mice
Bentzien, F.; Struman, Ingrid ULg; Martini, J. F. et al

in Cancer Research (2001), 61(19), 7356-62

The M(r) 16,000 NH(2)-terminal fragment of human prolactin (16K hPRL) is a potent antiangiogenic factor inhibiting endothelial cell function in vitro and neovascularization in vivo. The present study was ... [more ▼]

The M(r) 16,000 NH(2)-terminal fragment of human prolactin (16K hPRL) is a potent antiangiogenic factor inhibiting endothelial cell function in vitro and neovascularization in vivo. The present study was undertaken to test the ability of 16K hPRL to inhibit the growth of human HCT116 colon cancer cells transplanted s.c. into Rag1(-/-) mice. For this purpose, HCT116 cells were stably transfected with an expression vector encoding a peptide that included the signal peptide and first 139 amino acid residues of human prolactin (HCT116(16K)). Stable clones of HCT116(16K) cells secreted large amounts of biologically active 16K hPRL into the culture medium. Growth of HCT116(16K) cells in vitro was not different from wild-type HCT116 (HCT116(wt)) or vector-transfected HCT116 (HCT116(vector)) cells. Addition of recombinant 16K hPRL had no effect on the proliferation of HCT116(wt) cells in vitro. Tumor growth of HCT116(16K) cells implanted into Rag1(-/-) mice was inhibited 63% in four separate experiments compared with tumors formed from HCT116(wt) or HCT116(vector) cells. Inhibition of tumor growth of HCT116(16K) cells was correlated with a decrease in microvascular density by 44%. These data demonstrate that biologically active 16K hPRL can be expressed and secreted from human colon cancer cells using a gene transfer approach and that production of 16K hPRL by these cells was capable of inhibiting tumor growth and neovascularization. These findings support the potential of 16K hPRL as a therapeutic agent for the treatment of colorectal cancer. [less ▲]

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See detailAnalyse sociologique de la gestion des services de police, pour une compréhension par le jeu autour des règles
Schoenaers, Frédéric ULg

in Gestion : Revue Internationale de Gestion (2001), 25(4), 45-55

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See detailVerifìcarea unei structuri metalice pentru depozitare paletizata la actinuea focului
Zaharia, R.; Franssen, Jean-Marc ULg

in Zilele Academice Timisorene Editia VII - Buletinul Stiintific al Universitatii Politehnica din Timisoara (2001), 46(60), 288-298

The paper presents a fire design study case for a high-rise storage rack supporting building. Standardised ISO and natural fire models were considered for the fire action. The advanced numerical analysis ... [more ▼]

The paper presents a fire design study case for a high-rise storage rack supporting building. Standardised ISO and natural fire models were considered for the fire action. The advanced numerical analysis was carried out by means of SAFIR program, a FEM software specialised for the mechanical analysis of structures under elevated temperatures. [less ▲]

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See detailIpriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial.
Alexandersen, P; Toussaint, André ULg; Christiansen, C et al

in JAMA : Journal of the American Medical Association (2001), 285(11), 1482-8

CONTEXT: Data on the efficacy and safety of ipriflavone for prevention of postmenopausal bone loss are conflicting. OBJECTIVES: To investigate the effect of oral ipriflavone on prevention of ... [more ▼]

CONTEXT: Data on the efficacy and safety of ipriflavone for prevention of postmenopausal bone loss are conflicting. OBJECTIVES: To investigate the effect of oral ipriflavone on prevention of postmenopausal bone loss and to assess the safety profile of long-term treatment with ipriflavone in postmenopausal osteoporotic women. DESIGN AND SETTING: Prospective, randomized, double-blind, placebo-controlled, 4-year study conducted in 4 centers in Belgium, Denmark, and Italy from August 1994 to July 1998. PARTICIPANTS: Four hundred seventy-four postmenopausal white women, aged 45 to 75 years, with bone mineral densities (BMDs) of less than 0.86 g/cm(2). INTERVENTIONS: Patients were randomly assigned to receive ipriflavone, 200 mg 3 times per day (n = 234), or placebo (n = 240); all received 500 mg/d of calcium. MAIN OUTCOME MEASURES: Efficacy measures included spine, hip, and forearm BMD and biochemical markers of bone resorption (urinary hydroxyproline corrected for creatinine and urinary CrossLaps [Osteometer Biotech, Herlev, Denmark] corrected for creatinine), assessed every 6 months. Laboratory safety measures and adverse events were recorded every 3 months. RESULTS: Based on intent-to-treat analysis, after 36 months of treatment, the annual percentage change from baseline in BMD of the lumbar spine for ipriflavone vs placebo (0.1% [95% confidence interval (CI), -7.9% to 8.1%] vs 0.8% [95% CI, -9.1% to 10.7%]; P =.14), or in any of the other sites measured, did not differ significantly between groups. The response in biochemical markers was also similar between groups (eg, for hydroxyproline corrected for creatinine, 20.13 mg/g [95% CI, 18.85-21.41 mg/g] vs 20.67 mg/g [95% CI, 19.41-21.92 mg/g]; P =.96); urinary CrossLaps corrected for creatinine, 268 mg/mol (95% CI, 249-288 mg/mol) vs 268 mg/mol (95% CI, 254-282 mg/mol); P =.81. The number of women with new vertebral fracture was identical or nearly so in the 2 groups at all time points. Lymphocyte concentrations decreased significantly (500/microL (0.5 x 10(9)/L]) in women treated with ipriflavone. Thirty-one women (13.2%) in the ipriflavone group developed subclinical lymphocytopenia, of whom 29 developed it during ipriflavone treatment. Of these, 15 (52%) of 29 had recovered spontaneously by 1 year and 22 (81%) of 29 by 2 years. CONCLUSIONS: Our data indicate that ipriflavone does not prevent bone loss or affect biochemical markers of bone metabolism. Additionally, ipriflavone induces lymphocytopenia in a significant number of women. [less ▲]

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See detailCell cycle activation of hematopoietic progenitor cells increases very late antigen-5-mediated adhesion to fibronectin.
Giet, Olivier ULg; Huygen, Sandra; Beguin, Yves ULg et al

in Experimental hematology (2001), 29(4), 515-24

Recent studies suggested that trafficking of hematopoietic progenitor cells is related to cell cycle status. We studied whether adhesion of progenitor cells to extracellular matrix proteins was modulated ... [more ▼]

Recent studies suggested that trafficking of hematopoietic progenitor cells is related to cell cycle status. We studied whether adhesion of progenitor cells to extracellular matrix proteins was modulated by cell cycle transit.Mobilized peripheral blood CD34+ cells were stimulated ex vivo for 48 hours with stem cell factor, flt-3 ligand, and thrombopoietin and fractionated by adhesion to fibronectin or vascular cell adhesion molecule-1 (VCAM-1). Adherent and nonadherent cells were assayed for cell cycle status, long-term culture-initiating cell frequency, and integrin function. Binding to fibronectin, but not to VCAM-1, displayed a cell cycle selectivity as the adherent fraction to fibronectin was enriched in cycling CD34+ cells and in cycling long-term culture-initiating cells compared to the nonadherent fraction. Combined cell cycle and phenotypic analysis showed that the expression of VLA-5 was upregulated during S/G2+M but that of VLA-4 remained constant. The selective binding of cycling CD34+ cells to fibronectin was reverted by anti-VLA-5 but not by anti-VLA-4 blocking antibodies. Also, cycling CD34+ cells preferentially adhered to the VLA-5 binding domain but not to the VLA-4 binding domain of fibronectin. Adhesion of cycling CD34+ cells to fibronectin was a reversible process modulated by cell cycle progression, because adherent cells could exit the cell cycle and return to a nonadhesive state within an additional 48-hour culture period.The results indicate that the enhanced binding capacity of cycling progenitor cells to fibronectin is mediated by VLA-5. [less ▲]

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See detailSémiologie cardiaque dans l’espèce équine. 2- L’auscultation.
Amory, Hélène ULg

in Pratique Vétérinaire Equine (2001)

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See detailDose-dependent caffeine-induced conditioned locomotion in mice
Pirona, Alexandre; Ferrara, André Onofrio; Tirelli, Ezio ULg

in Behavioural Pharmacology (2001), 12

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See detailIdentification of Brucella spp. genes involved in intracellular trafficking.
Delrue, R. M.; Martinez-Lorenzo, M.; Lestrate, P. et al

in Cellular Microbiology (2001), 3(7), 487-97

After uptake by host cells, the pathogen Brucella transits through early endosomes, evades phago-lysosome fusion and replicates in a compartment associated with the endoplasmic reticulum (ER). The ... [more ▼]

After uptake by host cells, the pathogen Brucella transits through early endosomes, evades phago-lysosome fusion and replicates in a compartment associated with the endoplasmic reticulum (ER). The molecular mechanisms underlying these processes are still poorly understood. To identify new bacterial factors involved in these processes, a library of 1800 Brucella melitensis 16M mini-Tn5catkm mutants was screened for intracellular survival and multiplication in HeLa cells and J774A.1 macrophages. Thirteen mutants were identified as defective for their intracellular survival in both cell types. In 12 of them, the transposon had inserted in the virB operon, which encodes a type IV-related secretion system. The preponderance of virB mutants demonstrates the importance of this secretion apparatus in the intracellular multiplication of B. melitensis. We also examined the intracellular fate of three virB mutants (virB2, virB4 and virB9) in HeLa cells by immunofluorescence. The three VirB proteins are not necessary for penetration and the inhibition of phago-lysosomal fusion within non-professional phagocytes. Rather, the virB mutants are unable to reach the replicative niche and reside in a membrane-bound vacuole expressing the late endosomal marker, LAMP1, and the sec61beta protein from the ER membrane, proteins that are present in autophagic vesicles originating from the ER. [less ▲]

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See detailLa métallurgie ancienne en "Terre de Durbuy" : Utilisation des macroscories en dynamique fluviale
Houbrechts, Geoffrey ULg; Petit, François ULg

in Bulletin de la Société Géographique de Liège (2001), 40

Avant d’utiliser les scories métallurgiques comme traceur et indicateur de la compétence de l’Aisne à différents endroits de son cours, nous avons relevé les différents atouts qui ont favorisé le ... [more ▼]

Avant d’utiliser les scories métallurgiques comme traceur et indicateur de la compétence de l’Aisne à différents endroits de son cours, nous avons relevé les différents atouts qui ont favorisé le développement de la sidérurgie dans la « Terre de Durbuy » et nous avons étudié l’évolution des techniques sidérurgiques afin de mieux comprendre la genèse des scories. Dans cet article, nous étudions plus particulièrement l’évolution longitudinale de la taille des scories dans l’Aisne, entre Blier et Bomal où elle se jette dans l’Ourthe. Vu la trop grande proximité des sites de rejets, nous n’avons pu proposer qu’une vitesse minimum d’avancée de la charge de fond ; les scories prélevées nous ont cependant renseignés sur les variations de puissances spécifiques dans les différents tronçons de la rivière. [less ▲]

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See detailL'image du mois. L'hypotension orthostatique filmee par le Finapres: neuropathie autonome versus cause iatrogene.
Scheen, André ULg; Descampheleire, M.; Marchand, Monique ULg

in Revue Médicale de Liège (2001), 56(3), 133-4

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See detailL'invention de la mélancolie. Note sur l'ancienneté de la photographie
Havelange, Carl ULg

in Journal Français de Psychiatrie. Clinique, Scientifique et Psychanalytique (2001), 16

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See detailLucien Lambotte, esquisse biographique
Pirenne, Christophe ULg

in Revue de la Société liégeoise de Musicologie (2001), 18

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See detailGenetics of menopause-associated diseases.
Massart, François ULg; REGINSTER, Jean-Yves ULg; Brandi, M L

in Maturitas (2001), 40(2), 103-16

Menopause is the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. It is estimated that perhaps 50 million women worldwide will go into menopause annually ... [more ▼]

Menopause is the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. It is estimated that perhaps 50 million women worldwide will go into menopause annually. Atherosclerotic cardiovascular disease, osteoporotic fractures and Alzheimer's dementia are common chronic disorders after menopause, representing major health problems in most developed countries. Apart from being influenced by environmental factors, these chronic disorders recognize a strong genetic component, and there are now considerable clinic evidences that these disorders are related to low hormonal milieu of postmenopausal women. Here, we review up-to-date available data suggesting that genetic variation may contribute to higher susceptibility to four sporadic chronic syndromes such as osteoporosis (OP), osteoarthritis (OA), Alzheimer's disease (AD) and coronary artery disease (CAD). For these four syndromes candidate genes that today appear as major loci in genetic susceptibility encode for proteins specific of a given system, as the vitamin D receptor (VDR) gene for the skeleton and, therefore, OP or angiotensin converting enzyme (ACE) for the cardiovascular system and, therefore, CAD. The investigation of gene polymorphisms in various pathological conditions typical of postmenopause offer an explanation not only of their genetic inheritance but also of their co-segregation in given individuals. In this view, it may be possible to identify a common set of genes whose variants contribute to a common genetic background for these different disorders. Ideal candidates appear genes of the estrogen response cascade [i.e. estrogen receptor (ERs), enzymes involved in estrogen metabolism or co-activators and co-inhibitors]. All together this information may represent the basis both for future recognition of individuals at risk and for the pharmacogenetic driving of drug responsiveness. [less ▲]

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See detailEstimation of additive and nonadditive genetic variances in Hereford, Gelbvieh, and Charolais by Method R.
Duangjinda, M.; Bertrand, K.; Misztal, I. et al

in Journal of Animal Science (2001), 79(12), 2997-3001

Parameters for direct and maternal dominance were estimated in models that included non-additive genetic effects. The analyses used weaning weight records adjusted for age of dam from populations of ... [more ▼]

Parameters for direct and maternal dominance were estimated in models that included non-additive genetic effects. The analyses used weaning weight records adjusted for age of dam from populations of Canadian Hereford (n = 467,814), American Gelbvieh (n = 501,552), and American Charolais (n = 314,552). Method R estimates of direct additive genetic, maternal additive genetic, permanent maternal environment, direct dominance, and maternal dominance variances as a proportion of the total variance were 23, 12, 13, 19, and 14% in Hereford; 27, 7, 10, 18, and 2% in Gelbvieh; and 34, 15, 15, 23, and 2% in Charolais. The correlations between direct and maternal additive genetic effects were -0.30, -0.23, and -0.47 in Hereford, Gelbvieh, and Charolais, respectively. The correlations between direct and maternal dominance were -0.38, -0.02, and -0.04 in Hereford, Gelbvieh, and Charolais, respectively. Estimates of inbreeding depression were -0.20, -0.18, and -0.13 kg per 1% of inbreeding for Hereford, Gelbvieh, and Charolais, respectively. Estimates of the maternal inbreeding depression were -0.01, -0.02, and -0.02 kg, respectively. The high ratio of direct dominance to additive genetic variances provided some evidence that direct dominance effects should be considered in beef cattle evaluation. However, maternal dominance effects seemed to be important only for Hereford cattle. [less ▲]

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See detailLes sanctions administratives dans les communes : en route vers le droit communal armé
Masset, Adrien ULg

in Journal des Tribunaux (2001), 6031(2001), 833-838

La nouvelle loi belge du 13 mai 1999 permet désormais aux communes de réglementer une série de comportements en en assurant le respect par le recours à des sanctions administratives, alors qu’auparavant ... [more ▼]

La nouvelle loi belge du 13 mai 1999 permet désormais aux communes de réglementer une série de comportements en en assurant le respect par le recours à des sanctions administratives, alors qu’auparavant ces sanctions ne pouvaient être que pénales; la loi nouvelle offre aussi aux communes des pouvoirs de police administrative plus étendus; cette loi donne le ton d’une dépénalisation dans les communes au profit d’un droit administrativo-pénal [less ▲]

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See detailVisible light induced ring-opening metathesis polymerisation of cyclooctene
Delaude, Lionel ULg; Demonceau, Albert ULg; Noels, Alfred ULg

in Chemical Communications (2001), (11), 986-987

Under visible light irradiation, ruthenium-arene complexes bearing N-heterocyclic carbene ligands with aryl substituents - either preformed or generated in situ - are active catalyst precursors for the ... [more ▼]

Under visible light irradiation, ruthenium-arene complexes bearing N-heterocyclic carbene ligands with aryl substituents - either preformed or generated in situ - are active catalyst precursors for the ROMP of cyclooctene already at room temperature. [less ▲]

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See detailMélanges Fritz Sturm, compte rendu d’ouvrage
Langenaken, Evelyne ULg

in Actualités du droit (2001)

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See detailThe emerging role of class II histone deacetylases.
Fischle, Wolfgang; Kiermer, Véronique; Dequiedt, Franck ULg et al

in Biochemistry & Cell Biology (2001), 79(3), 337-48

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in all eukaryotes. Several histone acetyltransferases have been identified that ... [more ▼]

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in all eukaryotes. Several histone acetyltransferases have been identified that act as transcriptional coactivators. In contrast, histone deacetylases (HDACs) are part of transcriptional corepressor complexes. Based on their similarity to known yeast factors, the human HDACs are grouped into three classes. Class I HDACs are similar to the yeast transcriptional repressor yRPD3, while class II HDACs are related to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated in cell differentiation and development, and many molecular details are emerging that shed light on class II HDAC function and regulation. We discuss the biological role of these factors in the context of physiological processes. [less ▲]

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See detailLe travailleur adoptant
Kefer, Fabienne ULg; Barth, D.

in Actualités du Droit (2001)

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See detailLe portfolio : un outil de socio-construction pour scripteur en devenir
Baye, Ariane ULg; Denooz, Régine

in Caractères (2001), 3

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See detailApprendre à manfiester la compréhension des récits de fiction. Un instrument pour produire des questionnaire qui favorisent le développement de compétences.
Dumortier, Jean-Louis ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (2001), 51-52

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See detailLe transsexualisme et l'anorexie mentale : emprise et tyrannie de la subjectivité : approches méthodologiques
Mormont, Christian ULg; Frankignoul, A.; Michel, Aude

in Pratiques psychologiques (2001), (3), 25-36

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See detailEffets comportementaux et neurochimiques de stimuli associés à l’administration d'éthanol: implications pour les comportements d'alcoolisation
Quertemont, Etienne ULg; De Witte, Philippe

in Cahiers de l'I.R.E.B. (2001), 15

Les drogues, y compris l’alcool, peuvent servir de stimuli inconditionnels dans des situations d’apprentissage par conditionnement. Les stimuli environnementaux qui accompagnent systématiquement ... [more ▼]

Les drogues, y compris l’alcool, peuvent servir de stimuli inconditionnels dans des situations d’apprentissage par conditionnement. Les stimuli environnementaux qui accompagnent systématiquement l’administration d’alcool peuvent ainsi acquérir le statut de stimuli conditionnés capables d’induire à eux seuls des réactions physiologiques conditionnées. Deux types de réactions conditionnées avec l’alcool ont été observées. D’une part, les stimuli associés à l’administration d’alcool peuvent induire des effets similaires à ceux de l’éthanol. D’autre part, ces stimuli conditionnés à l’éthanol peuvent aussi engendrer des réponses conditionnées opposées aux effets de l’éthanol. Ces deux types de réponses conditionnées semblent jouer un rôle dans les différentes étapes de l’alcoolisation. Leur implication dans la tolérance envers l’éthanol est largement illustrée par le phénomène de tolérance dépendante de l’environnement. Plusieurs études expérimentales et observations cliniques suggèrent aussi que les processus de conditionnement pourraient être impliqués dans la consommation d’alcool et particulièrement dans son abus. Toutefois, les bases neurochimiques de ces réponses conditionnées à l’éthanol sont encore largement méconnues. De récentes études utilisant la technique de microdialyse intracérébrale ont pourtant montré le rôle de divers neurotransmetteurs et neuromodulateurs. D’une part, les réponses conditionnées similaires à l’éthanol sont accompagnées d’une libération de dopamine dans le noyau accumbens. D’autre part, la libération conditionnée de glutamate et de taurine semble être impliquée dans les réponses conditionnées opposées aux effets de l’éthanol. [less ▲]

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See detailDie endoluminale, kardiovaskuläre Radiotherapie:ein neuer Standard
Coucke, Philippe ULg; Ciernik, I-F

in Praxis (2001), 90

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of ... [more ▼]

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of coronary stenting further reducing cardiac morbidity. However, the incidence of restenosis after cardiovascular angioplasty remains high. The restenosis process is mainly explained by neo-intimal proliferation. Therefore, the utility of ionizing radiation has been systematically investigated in order to reduce proliferation of the neointimal tissue. Radiation therapy turns out to be a very efficient approach in reducing the rate of both de novo lesions as well as of instant restenosis. Recent clinical data from randomized trials confirm the utility of intracoronary radiation therapy and change the treatment standards in interventional cardiology. [less ▲]

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See detailEthno-agricultural approach to the rural environment in the prevention of Kashin-Beck disease
Malaisse, François ULg; Haubruge, Eric ULg; Mathieu, Françoise et al

in International Orthopaedics (2001), 25

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See detailCatalytic asymmetric dihydroxylation of C,C double bonds with osmium tetroxide using selenoxides as co-oxidants
Krief, A.; Colaux, Catherine ULg

in Synlett (2001), (4), 501-504

Asymmetric dihydroxylation of olefins has been achieved in good yields and ee's using potassium osmate dihydrate (K2OsO2(OH)(4), the pre-oxidant), (DHQD)(2)PHAL (the chiral ligand), potassium carbonate ... [more ▼]

Asymmetric dihydroxylation of olefins has been achieved in good yields and ee's using potassium osmate dihydrate (K2OsO2(OH)(4), the pre-oxidant), (DHQD)(2)PHAL (the chiral ligand), potassium carbonate (the base) and selenoxides (the co-oxidants). Bath the yield and the ee proved to be pH dependent, the highest yield and ee being found at almost the same pH values. The rate of the reaction was found to be highly dependent upon the structure of the selenoxide used. Some representative examples involving aminoxides are presented for comparison. [less ▲]

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See detailThe Vacuum UV Photoabsorption Spectrum of Methyl Chloride (CH3Cl) and its perdeuterated Isotopomer CD3Cl. I. A Rydberg Series Analysis.
Locht, Robert ULg; Leyh, Bernard ULg; Hoxha, A. et al

in Chemical Physics (2001), 272

The vacuum UV photoabsorption spectrum of CH3Cl has been recorded between 6 and 25 eV. A large number of vibronic bands are observed. These were partly ascribed to vibrationless Rydberg transitions. In ... [more ▼]

The vacuum UV photoabsorption spectrum of CH3Cl has been recorded between 6 and 25 eV. A large number of vibronic bands are observed. These were partly ascribed to vibrationless Rydberg transitions. In the higher energy range of 12-25 eV very weak diffuse bands are mostly assigned to transitions from the 3a1, 1e and 2a1 to 3s orbitals. In the 6-12 eV photon energy range, numerous weak to strong bands are observed. The sharpness of the features is very variable over the entire spectral region. In a first step, the interpretation of the spectrum and the assignment of the Rydberg transitions is based on the simple Rydberg formula. The observed features are classified in two groups of four series, each converging to one of the two spin-orbit components of the X2E state of CH3Cl+. Rydberg series of nsa1 (delta=1.069 and 1.064), npa1 (delta= 0.68 and 0.66), npe (delta= 0.438 and 0.427) and nd (delta= -0.040 and -0.092) characters are observed. The same measurements have been made for the first time on CD3Cl in the 6-12 eV photon energy range. The same Rydberg transitions are observed. Analogous series are characterized by about the same delta values: nsa1 (delta= 1.038 and 0.968), npa1 (delta= 0.65 and 0.61), npe (delta= 0.458 and 0.462) and nd (delta= -0.004 and -0.082). Ionization energies for CD3Cl X2E3/2 at 11.320 eV and X2E1/2 at 11.346 eV are deduced. In a second step, we fitted the experimental data for the nsa1 and npa1 states to an energy expression taking into account both the exchange interaction and the spin-orbit coupling. This accounts for the progressive switching from Hund's case (a) to Hund's case (c). [less ▲]

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See detailApoptosis in v-myc-transfected MSU-1.1 fibroblasts is induced by cell-matrix contact and differs from that of normal dermal fibroblasts.
Niland, S.; Cremer, A.; Herzhoff, K. et al

in In Vitro Cellular & Developmental Biology. Animal (2001), 37(9), 606-12

In order to characterize a fibroblast cell line representing normal human skin fibroblasts in three-dimensional cultures, we compared the fibroblast line MSU-1.1, derived from human foreskin and ... [more ▼]

In order to characterize a fibroblast cell line representing normal human skin fibroblasts in three-dimensional cultures, we compared the fibroblast line MSU-1.1, derived from human foreskin and immortalized by v-myc, to primary human dermal fibroblasts (NDF). Our results demonstrate that in contrast to NDF, all MSU-1.1 fibroblasts die within 3-4 d when cultured within three-dimensional contractile collagen matrices. Also, in contrast to NDF. MSU-1.1 cells die markedly in anchored collagen gels as well. Death is due to apoptosis and is attenuated by addition of antibodies against collagen-recognizing receptors alpha1beta1 and alpha2beta1. Apoptosis of NDF in collagen lattices was repressed by an inhibitor of caspase-1, which was ineffective on apoptosis of MSU-1.1. Further, apoptosis by MSU-1.l fibroblasts was also observed in anchored, i.e., restrained collagen lattices, an environment that supports proliferation of NDF. [less ▲]

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See detailNumerical modelling of coupled transient phenomena
Charlier, Robert ULg; Radu, Jean-Pol ULg; Collin, Frédéric ULg

in Revue Française de Génie Civil (2001), 5(6), 719-743

The basic phenomena involved in thermo-hydro-mechanical processes in geomaterials have been described in the 1st chapter. The equations describing these phenomena are non-linear differential equations ... [more ▼]

The basic phenomena involved in thermo-hydro-mechanical processes in geomaterials have been described in the 1st chapter. The equations describing these phenomena are non-linear differential equations. Their solution can generally only be approximated thanks to numerical methods. This is the main subject of the present chapter. First the type of problems and the set of equations to be solved will be shortly recalled. Emphasis will be given on the non-linear contributions. In a second section, the mostly developed numerical method, i.e. the finite difference and the finite element methods will be discussed under the light of the problems to be treated. The iterative techniques allowing the solution of non linear equations will be described. A third section will be dedicated to the coupling terms and to their modelling. The question that rises then is How to model efficiently problems, which may differ highly from, the point of view of the time and length scales? [less ▲]

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See detailEvaluation of ruthenium-based complexes for the controlled radical polymerization of vinyl monomers
Simal, François; Jan, Dominique; Delaude, Lionel ULg et al

in Canadian Journal of Chemistry (2001), 79(5-6), 529-535

New complexes of the type RuCl2(p-cymene)L where the ligand L is either a phosphine or a stable triazolinylidene carbene have been tested and compared to the Grubbs' benzylidene complex RuCl2(=CHPh)(PCy3 ... [more ▼]

New complexes of the type RuCl2(p-cymene)L where the ligand L is either a phosphine or a stable triazolinylidene carbene have been tested and compared to the Grubbs' benzylidene complex RuCl2(=CHPh)(PCy3)(2) as catalyst precursors for the controlled atom transfer radical polymerization (ATRP) of methyl methacrylate and of various para-substituted styrenes. Kinetic data and Hammett rho constants are reported, as well as the X-ray structure of the ortho-metallated triazolinylidene-ruthenium(II) complex RuCl(p-cymene)[1,2-phenylene[3,4-diphenyl-1H-1,2,4-triazol-1-yl-5(4H)-yl idene]]. [less ▲]

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See detailDe l'utilité de la modélisation numérique en hydrodynamique de surface
Archambeau, Pierre ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Ingenieurbiologie / Génie Biologique (2001), (4), 9-20

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See detailLife-cycle modelling of bequests and its implications for annuity valuation
Jousten, Alain ULg

in Journal of Public Economics (2001), 79

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes ... [more ▼]

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes.We find that consumption is non-increasing in the linear bequest parameter for the simplest certainty case, but that the same is not true for life-span uncertainty. Second, we study the issue of annuity valuation. For a sufficiently strong bequest motive, the true value of an annuity is equal to the actuarial value. This invalidates a previous claim that, for imperfect annuity markets, it is close to the simple financial value. [less ▲]

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See detailDu mode de définition de deux programmes de recherche en sociologie et en ethnométhodologie
Lejeune, Christophe ULg

in Carnets de Bord (2001), 2

Cet article examine la fondation de deux programmes scientifiques via l’étude de leur bibliographie, des traductions qu’ils opèrent et de leur définition de la mauvaise façon de faire science: leur ... [more ▼]

Cet article examine la fondation de deux programmes scientifiques via l’étude de leur bibliographie, des traductions qu’ils opèrent et de leur définition de la mauvaise façon de faire science: leur pathologie. Dans le « métier de sociologue », la cohérence entre l’importation bachelardienne de la rupture épistémologique et la sociologie critique permet de réaffirmer les dangers du substantialisme. L’ethnométhodologie s’offre quant à elle la sociologie comme pathologie. Elle traduit de manière singulière les règles de méthodes de Durkheim et Parsons en phénomènes ordinaires observables et descriptibles. L’analyse de l’opération concrète de fondation des principes de méthode de ces programmes de recherche sociologique offre une occasion d’envisager différemment le rapport de l’action à son contexte, de la sociologie à son objet, de la connaissance scientifique à la connaissance ordinaire. [less ▲]

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See detailTeloptosis, a Turning Point in Hair Shedding Biorhythms
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 203(2), 115-7

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from ... [more ▼]

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from teloptosis. Both events are triggered by distinct factors. Indeed, teloptosis is the result of the loss of adhesion between cells of the club hair and those of its epithelial envelope. Teloptosis synchronization is perceived as telogen effluvium, related or not to shortening of the anagen phase. Subtle changes leading to early or delayed teloptosis affect hair density. It is possible to distinguish two types of telogen hairs on a trichogram. Those with an epithelial sheath indicate strong binding, suggesting early telogen, whereas the absence of an epithelial sheath indicates loose binding, conveying teloptosis. [less ▲]

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See detailSpirometric performance in Belgian Blue calves: I. Effects on economic losses due to the bovine respiratory disease complex.
Bureau, Fabrice ULg; Detilleux, Johann ULg; Dorts, T. et al

in Journal of Animal Science (2001), 79(5), 1301-1304

The aim of this study was to determine whether high spirometric performances in calves are associated with low economic losses due to the bovine respiratory disease complex (BRDC). Five spirometric ... [more ▼]

The aim of this study was to determine whether high spirometric performances in calves are associated with low economic losses due to the bovine respiratory disease complex (BRDC). Five spirometric variables (SV) were measured in 909 double-muscled Belgian Blue calves from 15 to 60 d of age. Afterward, calves were monitored for 6 mo to determine whether they developed BRDC and to determine the costs due to BRDC (i.e., medicine costs and veterinarians' fees, plus estimated financial losses due to mortality in case of death). To analyze the effects of spirometric performances on BRDC cost, a fixed linear model was used for each SV. In addition to SV, each model included the effects of sex, dam's parity, vaccination status, muscular development score, herd-period, and BW. Only herd-period and the maximal ventilation and the vital capacity had significant effects on costs due to BRDC, indicating that these two SV are major physiological determinants of economic losses associated with BRDC. Accordingly, it is assumed that an amelioration of maximal ventilation and vital capacity could result in increased resistance to BRDC in calves. [less ▲]

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See detailCrystal Structure of Human Peroxiredoxin 5, a Novel Type of Mammalian Peroxiredoxin at 1.5 Ǻ Resolution
Declercq, Jean-Paul; Evrard, Christine ULg; Clippe, André et al

in Journal of Molecular Biology (2001), 311

The peroxiredoxins define an emerging family of peroxidases able to reduce hydrogen peroxide and alkyl hydroperoxides with the use of reducing equivalents derived from thiol-containing donor molecules ... [more ▼]

The peroxiredoxins define an emerging family of peroxidases able to reduce hydrogen peroxide and alkyl hydroperoxides with the use of reducing equivalents derived from thiol-containing donor molecules such as thioredoxin, glutathione, trypanothione and AhpF. Peroxiredoxins have been identified in prokaryotes as well as in eukaryotes. Peroxiredoxin 5 (PRDX5) is a novel type of mammalian thioredoxin peroxidase widely expressed in tissues and located cellularly to mitochondria, peroxisomes and cytosol. Functionally, PRDX5 has been implicated in antioxidant protective mechanisms as well as in signal transduction in cells. We report here the 1.5 Ǻ resolution crystal structure of human PRDX5 in its reduced form. The crystal structure reveals that PRDX5 presents a thioredoxin-like domain. Interestingly, the crystal structure shows also that PRDX5 does not form a dimer like other mammalian members of the peroxiredoxin family. In the reduced form of PRDX5, Cys47 and Cys151 are distant of 13.8 Ǻ although these two cysteine residues are thought to be involved in peroxide reductase activity by forming an intramolecular disul®de intermediate in the oxidized enzyme. These data suggest that the enzyme would necessitate a conformational change to form a disulfide bond between catalytic Cys47 and Cys151 upon oxidation according to proposed peroxide reduction mechanisms. Moreover, the presence of a benzoate ion, a hydroxyl radical scavenger, was noted close to the active-site pocket. The possible role of benzoate in the antioxidant activity of PRDX5 is discussed. [less ▲]

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See detailGene structure and promoter function of a teleost ribosomal protein: a tilapia (Oreochromis mossambicus) L18 gene
Molina, Alfredo; Iyengar, Arati; Marins, Luis F. et al

in Biochimica et Biophysica Acta (2001), 1520(3), 195-202

We have cloned and characterized a tilapia (Oreochromis mossambicus) L18 ribosomal protein gene, including the complete transcribed region and 488 bp of upstream regulatory sequences. We have also ... [more ▼]

We have cloned and characterized a tilapia (Oreochromis mossambicus) L18 ribosomal protein gene, including the complete transcribed region and 488 bp of upstream regulatory sequences. We have also isolated two L18 cDNAs from another tilapia (Oreochromis niloticus) with a few conservative nucleotide differences. Our results suggest the presence of two genes in both species. Reporter constructs were tested for transient expression in CV1 cells and in microinjected zebrafish and tilapia embryos. The tilapia L18 promoter was able to drive expression of the reporter gene in all three experiments, with no apparent preference for a particular tissue. The tilapia L18 promoter is therefore likely to be a powerful tool to drive tissue-independent gene expression in fish. [less ▲]

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See detailCaractérisation et valorisation du savoir paysan sur les insectes nuisibles du pois cajan (Cajanus cajan (L.) Millsp.) dans le Nord de l'Ouganda
Velay, F.; Baudoin, Jean-Pierre ULg; Mergeai, Guy ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(2), 105-114

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See detailPharma clinics. Le medicament du mois. Le clopidogrel (Plavix).
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(3), 186-9

Clopidogrel is launched in Belgium by Sanofi-Synthelabo and Bristol-Myers Squibb under the trade name of Plavix. It is a potent and irreversible ADP receptor antagonist that proved to be more effective ... [more ▼]

Clopidogrel is launched in Belgium by Sanofi-Synthelabo and Bristol-Myers Squibb under the trade name of Plavix. It is a potent and irreversible ADP receptor antagonist that proved to be more effective than aspirin as antiplatelet agent in the multicentre, randomised double-blind CAPRIE study. It is indicated, at a dosage of 75 mg/day, for the reduction of atherosclerotic events including myocardial infarction, ischaemic stroke and vascular death in patients with atherosclerosis manifested by recent stroke, myocardial infarction or established peripheral vascular disease. Furthermore, recent studies demonstrated that the combination of clopidogrel with aspirin is more effective than aspirin alone and better tolerated than the combination ticlopidine-aspirin for the prevention of atherothrombosis after placement of intravascular stents. Ongoing trials are evaluating the efficacy and safety of such clopidogrel-aspirin combination after acute ischaemic coronary events or in patients at very high risk of stroke. Thus the indications of clopidogrel may become even larger in a next future. [less ▲]

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See detailAn algorithm and a method to search bifurcation points in non-linear problems
Chambon, René; Crochepeyre, Stéphane; Charlier, Robert ULg

in International Journal for Numerical Methods in Engineering (2001), 51(3), 315-332

This paper is devoted to a numerical method able to help the determination of the bifurcation threshold in non-linear time-independent continuum mechanic problems. First, some theoretical results about ... [more ▼]

This paper is devoted to a numerical method able to help the determination of the bifurcation threshold in non-linear time-independent continuum mechanic problems. First, some theoretical results about uniqueness are recalled. In the framework of the large-strain assumption, the differences between the classical finite-step problem and the rate problem are presented. An iterative algorithm able to solve the rate problem is given. Using different initializations, it is seen in some numerical experiments that it is possible with this algorithm to get different solutions when the underlying mathematical problem solved does not enjoy a uniqueness property. The constitutive equations used have been chosen to be simple enough to deduce some theoretical knowledge about the corresponding uniqueness problems. Finally, a method is given which is able in some case to give an upper bound of the bifurcation threshold. Copyright (C) 2001 John Wiley & Sons, Ltd. [less ▲]

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See detailL'exercice physique pour prevenir l'obesite, favoriser l'amaigrissement et maintenir la perte ponderale.
Scheen, André ULg; Rorive, Marcelle ULg; Letiexhe, Michel ULg

in Revue Médicale de Liège (2001), 56(4), 244-7

Obesity is a multifactorial disease making difficult the determination of the precise role of one specific factor such as physical activity or sedentary. Nevertheless, numerous arguments, derived from ... [more ▼]

Obesity is a multifactorial disease making difficult the determination of the precise role of one specific factor such as physical activity or sedentary. Nevertheless, numerous arguments, derived from epidemiological observational studies or from randomized controlled interventional trials, support a favourable role of regular physical activity in the control of body weight. Physical activity contributes to prevent the occurrence of weight excess, especially in children or adolescents, to obtain a satisfactory weight loss, in general in combination with reduced-energy diets, and to maintain long-term weight loss. In addition, physical activity improves both the metabolic profile and health of obese subjects. [less ▲]

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See detailLe portage asymptomatique de Microsporum canis chez le chat
Mignon, Bernard ULg; Brouta, F.; Descamps, F. et al

in Annales de Médecine Vétérinaire (2001), 145

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See detailDietary habits during adolescence - results of the Belgian Adolux Study
Paulus, Dominique; Saint-Remy, Annie ULg; JeanJean, Michel

in European Journal of Clinical Nutrition (2001), 55

STUDY: To analyse the usual dietary habits of Belgian adolescents from a high cardiovascular risk population. METHODS: A food frequency questionnaire (57 items) was administered to the whole sample ... [more ▼]

STUDY: To analyse the usual dietary habits of Belgian adolescents from a high cardiovascular risk population. METHODS: A food frequency questionnaire (57 items) was administered to the whole sample. Complementary questions specified some types of food (eg fat content). A subgroup of 234 adolescents gave detailed information on portion size (picture book and food samples). SETTING: Twenty-four secondary schools in the Belgian province of Luxembourg. SUBJECTS: A total of 1,526 adolescents (12-17y) selected by a multiclustered stage sampling (participation: 83.6%). RESULTS: Respectively 46% and 60% of the adolescents did not eat fruit and vegetables daily. Most of the adolescents (72%) consumed at least one dairy product daily. The frequent consumption of chocolate and French fries indicated the strong cultural influence on dietary habits while imported foods (like hamburgers) had little success. One-third of the adolescents (33%, n = 509) drank alcohol at least once a week and this proportion rose to 57% in the oldest age group. Boys and girls differed significantly in their diet, with girls choosing healthier foods. Dietary habits, in particular drinking habits, differed also significantly between education levels, assessed by the learning option of the participants. The semi-quantitative questionnaire showed that two-thirds of the adolescents had a lipid intake (mainly saturated fatty acids) which exceeded 35% of the total caloric intake. Complex carbohydrates represented less than half of the total carbohydrates intake. CONCLUSION: The study of the diet of Belgian adolescents confirmed the strong influence of tradition, in particular on the consumption of high fat content foods. The promotion of healthy diet in adolescents should consider the cultural influence, even for this young age group [less ▲]

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See detailRole de l'inhibiteur des activateurs de plasminogene de type 1 dans l'angiogenese tumorale
Bajou, Khalid ULg; Devy, L.; Masson, Véronique ULg et al

in Thérapie (2001), 56(5, Sep-Oct), 465-72

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen ... [more ▼]

The plasminogen/plasmin system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumour cell migration. High levels of components of the plasminogen activation system, and paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI-1), have been correlated with a poor prognosis for patients with cancers of different types. Recent findings clearly suggest that PAI-1 is essential for capillary sprouting during tumour angiogenesis. Moreover, there is accumulating evidence that both the urokinase receptor and PAI-1 are multifunctional proteins involved not only in extracellular matrix proteolysis but also in cellular adhesion and migration through their binding site for vitronectin. The understanding of whether PAI-1 plays a regulatory role in angiogenesis by tightly controlling proteolytic activity or by influencing cell migration could allow a new anti-angiogenic approach for tumour therapy. [less ▲]

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See detailNouvelles approches thérapeutiques puor l'hypernéphrome métastasique
Sylvestre, Rose-Marie; Jerusalem, Guy ULg; Sautois, Brieuc ULg et al

in Médecine et Hygiène (2001), 59

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See detailL'activité physique de jeunes adolescents en Communauté française de Belgique
Piéron, Maurice; Cloes, Marc ULg

in Revue de l'Education Physique (2001), 41(1), 42-48

La santé figure dans la plupart des préoccupations des théoriciens et des praticiens de l'éducation physique. Les effets de santé associés à la pratique régulière d'activités physiques suscitent un ... [more ▼]

La santé figure dans la plupart des préoccupations des théoriciens et des praticiens de l'éducation physique. Les effets de santé associés à la pratique régulière d'activités physiques suscitent un intérêt fondamental chez de nombreux chercheurs. En effet, à deux reprises, un groupe de consensus s'est réuni pour établir un bilan des certitudes et des doutes en matière de relations entre l'activité physique et la santé. ... [less ▲]

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See detailCarbon sinks in temperate forests
Martin, Philippe; Nabuurs, G. J.; Aubinet, Marc ULg et al

in Annual Review of Energy & the Environment (2001), 26

In addition to being scientifically exciting, commercially important, and environmentally essential, temperate forests have also become a key diplomatic item in international climate negotiations as ... [more ▼]

In addition to being scientifically exciting, commercially important, and environmentally essential, temperate forests have also become a key diplomatic item in international climate negotiations as potential sinks for carbon. This review presents the methods used to estimate carbon sequestration, identifies the constraints and opportunities for carbon sequestration in temperate forests, addresses the issues raised by the monitoring of carbon sequestration, and analyzes uncertainties pertaining to the sequestration of carbon by temperate forests. This review serves a dual purpose: It aims at informing policy makers about carbon sequestration in temperate forests and at making forest ecologists, biogeochemists, and atmospheric scientists aware of the structure of an international agreement to reduce CO2 and other greenhouse gas emissions and some of the real, still answered scientific questions that it poses. [less ▲]

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See detailMother-Young Relationships in Belgian Blue Cattle after a Caesarean Section: Characterisation and Effects of Parity
Vandenheede, Marc ULg; Nicks, Baudouin ULg; Desiron, A. et al

in Applied Animal Behaviour Science (2001), 72(3), 281-292

The systematic use of Caesarean section in "double muscled" Belgian Blue cattle can induce ethical concerns. The aims of the following study was to characterise mother-young relationships in such a ... [more ▼]

The systematic use of Caesarean section in "double muscled" Belgian Blue cattle can induce ethical concerns. The aims of the following study was to characterise mother-young relationships in such a situation and to assess the effect of parity. Fifteen heifers and 15 cows of the Belgian Blue breed were observed using video recording when isolated with their calf during the 3 days following Caesarean, a rapid surgery with rare occurrence of aggressive behaviour and no sign of cows' discomfort or weakness. All calves were bottle-fed mother's colostrum once before first suckling occurred. Heifers' calves received a supplementary number of three such artificial meals, while cows' calves needed only one. The overall median time to first licking of the calf by the mother was 3.3min without any effect of parity. The mean licking frequency was 29.2+/-15.8 per 24h: heifers licked their calf less frequently than cows, respectively 23.4+/-15.3 per 24h versus 35.1+/-14.5 per 24h (P<0.05). The mean total licking duration was 42.2+/-25.9min per 24h: there was no significant difference between heifers and cows. The overall median time to first suckling was 6.1h, without any effect of parity. The mean suckling frequency was 8.4+/-4.8 per 24h: for half of these suckling bouts, the calf was situated on the left side of the mother, i.e. the side of the scar. The suckling frequency was negatively correlated with the number of artificial meals (r(s)=-0.45,P<0.05). Heifers suckled their calf less often than cows, respectively 6.1+/-3.1 per 24h versus 10.7+/-5.2 per 24h (P<0.01), but the left side proportion was not significantly different. The mean suckling total duration was 35.3+/-21.0min per 24h. The calf was on the left side of the mother during half of this time. Heifers suckled their calf during a shorter time than cows, respectively 26.9+/-20.0min per 24h versus 43.8+/-19.1min per 24h (P<0.05), and the left side proportion was not significantly different. Licking frequency and suckling duration were positively correlated (r=0.43,P<0.05). Only 10% of the mothers (one heifer and two cows) butted their calf and kicking was never observed. Despite the difficult comparison with results of the literature according to various methodologies, mother-young relationships were considered as similar to those reported after natural calving. In our study, cows can be considered as better mothers than heifers. [less ▲]

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See detailThe Immuno-Inflammatory Reaction in Crohn's Disease and Ulcerative Colitis: Characterisation, Genetics and Clinical Application. Focus on Tnf Alpha
Louis, Edouard ULg

in Acta Gastro-Enterologica Belgica (2001), 64(1), 1-5

Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-inflammatory reaction, on genetic predisposition and on potential ... [more ▼]

Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-inflammatory reaction, on genetic predisposition and on potential clinical application of blood immuno-inflammatory markers in these diseases. This paper summarizes some aspects of this work, focusing on TNF. Following points are developed: production of TNF by inflamed mucosa, genetic control of TNF production, TNF gene polymorphim in inflammatory bowel disease, and evaluation of serum TNF as a marker of disease activity or evolutivity. [less ▲]

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See detailLa marca de Marcos. ¿Pueden hablar los indígenas mexicanos ?
Vanden Berghe, Kristine ULg

in Cuadernos Americanos (2001), 87

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See detailElaboration d'une batterie d'évaluation des fonctions cognitives de sujets âgés porteurs d'un syndrome de Down
Georges, M.; Théwis, B.; Van der Linden, Martial ULg et al

in Revue de Neuropsychologie (2001), 11

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See detailAugmented Lagrangian procedure for implicit computation of contact-impact between deformable bodies.
Graillet, D.; Ponthot, Jean-Philippe ULg; Stainier, Laurent ULg

in International Journal of Crashworthiness (2001), 6(2), 209-221

This paper shows how efficiency can be improved by using an adequate Augmented Lagrangian procedure instead of the classical and well-known Penalty method for solving contact-impact problems between ... [more ▼]

This paper shows how efficiency can be improved by using an adequate Augmented Lagrangian procedure instead of the classical and well-known Penalty method for solving contact-impact problems between deformable bodies, including frictional contact, large deformations, dynamical effects and inelasticity phenomena The Augmented Lagrangian method has already enjoyed great success in solving constrained minimisation problems or incompressibility conditions. Alternatives to existing automation techniques for augmentations are presented. Starting from a Penalty method, it will be seen how the Augmented Lagrangian decreases ill-conditioning of governing equations and gives a more precise solution with a lower CPU-cost. Several original simultaneous criteria are proposed for optimising the number and the location of the augmentations in an incremental implicit resolution. Application of the method is done for two axisymmetric impact problems. [less ▲]

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See detailVenlafaxine induced hair loss
PITCHOT, William ULg; ANSSEAU, Marc ULg

in American Journal of Psychiatry (The) (2001)

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See detailActualites therapeutiques 2001.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(9), 612-24

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule as well as its modalities of appropriate use in clinical practice will be pointed out. [less ▲]

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See detailEffect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group.
McClung, M R; Geusens, P; Miller, P D et al

in New England Journal of Medicine [=NEJM] (2001), 344(5), 333-40

BACKGROUND: Risedronate increases bone mineral density in elderly women, but whether it prevents hip fracture is not known. METHODS: We studied 5445 women 70 to 79 years old who had osteoporosis ... [more ▼]

BACKGROUND: Risedronate increases bone mineral density in elderly women, but whether it prevents hip fracture is not known. METHODS: We studied 5445 women 70 to 79 years old who had osteoporosis (indicated by a T score for bone mineral density at the femoral neck that was more than 4 SD below the mean peak value in young adults [-4] or lower than -3 plus a nonskeletal risk factor for hip fracture, such as poor gait or a propensity to fall) and 3886 women at least 80 years old who had at least one nonskeletal risk factor for hip fracture or low bone mineral density at the femoral neck (T score, lower than -4 or lower than -3 plus a hip-axis length of 11.1 cm or greater). The women were randomly assigned to receive treatment with oral risedronate (2.5 or 5.0 mg daily) or placebo for three years. The primary end point was the occurrence of hip fracture. RESULTS: Overall, the incidence of hip fracture among all the women assigned to risedronate was 2.8 percent, as compared with 3.9 percent among those assigned to placebo (relative risk, 0.7; 95 percent confidence interval, 0.6 to 0.9; P=0.02). In the group of women with osteoporosis (those 70 to 79 years old), the incidence of hip fracture among those assigned to risedronate was 1.9 percent, as compared with 3.2 percent among those assigned to placebo (relative risk, 0.6; 95 percent confidence interval, 0.4 to 0.9; P=0.009). In the group of women selected primarily on the basis of nonskeletal risk factors (those at least 80 years of age), the incidence of hip fracture was 4.2 percent among those assigned to risedronate and 5.1 percent among those assigned to placebo (P=0.35). CONCLUSIONS: Risedronate significantly reduces the risk of hip fracture among elderly women with confirmed osteoporosis but not among elderly women selected primarily on the basis of risk factors other than low bone mineral density. [less ▲]

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See detailNumerations systems on a regular language
Lecomte, Pierre ULg; Rigo, Michel ULg

in Theory of Computing Systems (2001), 34

Generalizations of positional number systems in which N is recognizable by finite automata are obtained by describing an arbitrary infinite regular language according to the lexicographic ordering. For ... [more ▼]

Generalizations of positional number systems in which N is recognizable by finite automata are obtained by describing an arbitrary infinite regular language according to the lexicographic ordering. For these systems of numeration, we show that ultimately periodic sets are recognizable. We also study translation and multiplication by constants as well as the order-dependence of the recognizability. [less ▲]

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See detailHeterogeneity of (co)variance components for Jersey type traits
Gengler, Nicolas ULg; Dusseldorf, T.; Wiggans, G. R. et al

in Journal of Dairy Science (2001), 84

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See detailNumeration systems on a regular language : Arithmetic operations, Recognizability and Formal power series
Rigo, Michel ULg

in Theoretical Computer Science (2001), 269

Generalizations of numeration systems in which \(\N\) is recognizable by a finite automaton are obtained by describing a lexicographically ordered infinite regular language \(L\subset \Sigma^*\). For ... [more ▼]

Generalizations of numeration systems in which \(\N\) is recognizable by a finite automaton are obtained by describing a lexicographically ordered infinite regular language \(L\subset \Sigma^*\). For these systems, we obtain a characterization of recognizable sets of integers in terms of $\N$-rational formal series. After a study of the polynomial regular languages, we show that, if the complexity of \(L\) is \(\Theta (n^l)\) (resp. if \(L\) is the complement of a polynomial language), then multiplication by \(\lambda\in \N\) preserves recognizability only if \(\lambda=\beta^{l+1}\) (resp. if \(\lambda\neq (\#\Sigma)^\beta\)) for some \(\beta\in \N\). Finally, we obtain sufficient conditions for the notions of recognizability for abstract systems and some positional number systems to be equivalent. [less ▲]

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See detailFusariose disséminée chez un patient immunodéprimé
QUATRESOOZ, Pascale ULg; Meiers, I.; ARRESE ESTRADA, Jorge ULg et al

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2001), 28

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See detailInfo-congres. La cochrane collaboration, porte-parole de la medecine factuelle.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(11), 796-8

During the 9th International Cochrane Colloquium (Lyon October 9-13, 2001), around 700 participants discussed about how to make the evidence dissemination process more efficient in order to promote the ... [more ▼]

During the 9th International Cochrane Colloquium (Lyon October 9-13, 2001), around 700 participants discussed about how to make the evidence dissemination process more efficient in order to promote the Evidence-Based Medicine. The best evidence is summarized in systematic reviews of randomised and/or controlled clinical trials within the Cochrane Library which are prepared with a high methodological quality. However, these reviews should be completed to cover all medical domains, be actualized regularly, and, most importantly, be better known and more largely used by physicians in routine practice. All these objectives could not be attained without an official recognition and a financial support by the public health authorities. [less ▲]

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See detailDes gribouillis aux premières lettres : le développement précoce de l’écrit.
Maillart, Christelle ULg; Schelstrate, Marie-Anne

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2001), 34(2), 103-120

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See detailHepatotoxicity with thiazolidinediones: is it a class effect?
Scheen, André ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (2001), 24(12), 873-88

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications ... [more ▼]

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications. Thiazolidinediones, more commonly termed glitazones, are the first drugs to specifically target muscular insulin resistance. They have proven efficacy for reducing plasma glucose levels in patients with type 2 diabetes mellitus treated with diet alone, sulphonylureas, metformin or insulin. In addition, they are associated with some improvement of the cardiovascular risk profile. However, troglitazone, the first compound approved by the Food and Drug Administration in the US, proved to be hepatotoxic and was withdrawn from the market after the report of several dozen deaths or cases of severe hepatic failure requiring liver transplantation. It remains unclear whether or not hepatotoxicity is a class effect or is related to unique properties of troglitazone. Rosiglitazone and pioglitazone, two other glitazones, appear to have similar efficacy with regard to blood glucose control in patients with type 2 diabetes mellitus as compared with troglitazone. In controlled clinical trials, the incidence of significant (> or =3 x upper limit of normal) increases in liver enzyme levels (ALT in particular) was similar with rosiglitazone or pioglitazone as compared with placebo, whereas troglitazone was associated with a 3-fold greater incidence. In contrast to the numerous case reports of acute liver failure in patients receiving troglitzone, only a few case reports of hepatotoxicity have been reported in patients treated with rosiglitazone until now, with a causal relationship remaining uncertain. Furthermore, no single case of severe hepatotoxicity has been reported yet with pioglitazone. It should be mentioned that troglitazone, unlike pioglitazone and rosiglitazone, induces the cytochrome P450 isoform 3A4, which is partly responsible for its metabolism, and may be prone to drug interactions. Importantly enough, obesity, insulin resistance and type 2 diabetes mellitus are associated with liver abnormalities, especially non-alcoholic steatohepatitis, independent of any pharmacological treatment. This association obviously complicates the selection of patients who are good candidates for a treatment with glitazones as well as the monitoring of liver tests after initiation of therapy with any thiazolidinedione compound. While regular monitoring of liver enzymes is still recommended and more long term data are desirable, current evidence from clinical trials and postmarketing experience in the US supports the conclusion that rosiglitazone and pioglitazone do not share the hepatotoxic profile of troglitazone. [less ▲]

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See detailChronic rupture of abdominal aortic aneurysm manifesting as crural neuropathy.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; LAVIGNE, Jean-Paul ULg et al

in Annals of Vascular Surgery (2001), 15(3), 405-11

Chronic rupture of abdominal aortic aneurysm (AAA) resulting in unusual clinical manifestations can occur if the resistance of structures surrounding the aorta is sufficient to contain hemorrhage. In this ... [more ▼]

Chronic rupture of abdominal aortic aneurysm (AAA) resulting in unusual clinical manifestations can occur if the resistance of structures surrounding the aorta is sufficient to contain hemorrhage. In this report, we describe five cases of chronic ruptured AAA in which the presenting feature was crural neuropathy. All patients were male with a mean age of 74 +/- 1.8 years. At the time of presentation, crural neuropathy had been ongoing for 3 to 9 weeks. In three cases, AAA was not initially suspected because an inadequate clinical examination was performed (not in the vascular surgery department) and because of the small diameter of the aorta in relation to the patient's morphology. Two patients had one episode of hypotension that was wrongly attributed to vagal attack. Abdominal CT scanning was always diagnostic of chronic rupture. In two cases, rupture was associated with erosion of the body of one or more vertebrae and laboratory evidence of inflammation, i.e., increase in sedimentation rate and fibrinogen level. The mean diameter of the AAA was 7.1 +/- 0.9 cm (range 5-10 cm). All patients underwent midline laparotomy, which was performed under emergency conditions in two cases, under semi-emergency conditions in one case, and electively in two cases. Perforation was consistently located on the posterolateral wall of the aorta and varied from 1 to 3 cm in length. Repair was performed using an aortobifemoral prosthesis in four cases, and a straight tube in one case. The patient who underwent emergency surgery died 4 days after the procedure. The remaining four patients recovered uneventfully and were discharged after 10 days. In the elderly, ruptured AAA should be included in the differential diagnosis of crural neuropathy. An episode of hypotension, regardless of its duration, in an elderly patient should be given serious consideration as a possible sign of ruptured AAA with ongoing retroperitoneal hemorrhage. [less ▲]

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See detailCopper And Vegetation At The Kansanshi Hill (Zambia) Copper Mine
Leteinturier, B.; Baker, Ajm.; Bock, Laurent ULg et al

in Belgian Journal of Botany (2001), 134(1),

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See detail33 RENO: A European surveillance registry of coronary brachytherapy with the NovosteTM Beta-CathTM System
Coen, V.; Sauerwein; Orrechia et al

in Radiotherapy & Oncology (2001), 60(supp 1), 12

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See detailL'immigration subsaharienne en Belgique
Martiniello, Marco ULg; Kagné, Bonaventure

in Courrier Hebdomadaire du CRISP (2001), 1721

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See detailMons/Maisières : le site de plein air de Maisières-Canal
Miller, Rebecca ULg; Otte, Marcel ULg; Haesaerts, Paul

in Chronique de l'Archéologie Wallonne (2001), 9

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See detailLe domicile : une notion plurielle
d'Huart, Véronique ULg

in Répertoire notarial (2001), VII

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See detailGenotypical and phenotypical characterization of potential virulence of intestinal avian Escherichia coli strains isolated in Algeria
Mellata, M.; Bakour, R.; Jacquemin, E. et al

in Avian Diseases (2001), 45

In order to characterize potential pathogenic Escherichia coli strains isolated from diarrheic hens and chickens originating from intensive battery rearing in North Algeria, the presence of a large range ... [more ▼]

In order to characterize potential pathogenic Escherichia coli strains isolated from diarrheic hens and chickens originating from intensive battery rearing in North Algeria, the presence of a large range of virulence factors and markers was studied in 50 strains by DNA-DNA hybridization on colonies and phenotypic tests. The sequences we focused on were those coding for adhesins F5, F41, F17, Pap, Afa, and Sfa; intimin Eae; and toxins STa, STb, LT1, Stx1, Stx2, CNF1, and CNF2. The phenotypes explored were the colicins, aerobactin, hemolysins, and hemagglutinin production and serum resistance. The genotypic and phenotypic tests enabled us to categorize the isolates into two distinct groups: those with a potential to invade the host (27 strains were serum resistant and/or produced aerobactin), among which three strains were also potentially diarrheagenic, one strain was LT1 + F17+ Afa+ Pap+ (enterotoxigenic E. coli) and the two others were Stx1 (verotoxigenic E. coli). Twenty-three strains were colicinogenic, including 19 strains producing colicin V. This latter factor was also detected in isolates negative for the other virulence factors. On the basis of the type of erythrocytes agglutinated, we established 14 mannose-resistant hemagglutination patterns among the 37 strains tested, including 22 serum-resistant and/or aerobactin producing strains and 15 strains negative for these two characters. None of the strains produced alpha hemolysin, whereas two strains produced beta hemolysin and enterohemolysin, respectively. Congo red fixation was observed in 25 strains. No relationship could be detected between Congo red fixation and the presence of other virulence markers, such as serum resistance and aerobactin production. This study shows that among isolates originating from the feces of diarrheic chickens, the proportion of potentially diarrheagenic E. coli strains is low. [less ▲]

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See detailPex, Analytical Tools For Pdb Files. II. H-Pex: Noncanonical H-Bonds In Alpha-Helices
Thomas, Annick ULg; Benhabiles, N.; Meurisse, R. et al

in Proteins-Structure Function and Genetics (2001), 43(1), 37-44

We use the H-Pex (Thomas et al., this issue) to analyze the main chain interactions in 131 proteins. In antiparallel beta-sheets, the geometry of the N...O bond is: median N...O distances, 2.9 SA, C==O ... [more ▼]

We use the H-Pex (Thomas et al., this issue) to analyze the main chain interactions in 131 proteins. In antiparallel beta-sheets, the geometry of the N...O bond is: median N...O distances, 2.9 SA, C==O...N angles at 154 degrees and the C alpha--C==O...H angles are dispersed around 3 degrees. In some instances, the other side of the C==O axis is occupied by a HC alpha. As recently supported by Vargas et al. (J Am Chem Soc 2000;122:4750-4755) C alpha H...O and NH...O could cooperate to sheet stability. In alpha-helices, the main chain C==O interact with the NH of their n + 4 neighbor on one side, and with a C beta H or C gamma H on the other side. The median O...N distance (3.0 A) and C==N angle (147 degrees) suggest a canonical H-bond, but the C alpha--C==O...H dihedral angle invalidates this option, since the hydrogen attacks the oxygen at 122 degrees, i.e., between the sp(2) and pi orbitals. This supports that the H-bond is noncanonical. In many instances, the C gamma H or the C beta H of the n + 4 residue stands opposite to the NH with respect to the oxygen. Therefore, we propose that, in alpha-helices, the C gamma H or C beta H and the NH of the n + 4 residue hold the oxygen like an electrostatic pincher. [less ▲]

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See detailWell-ordered spherical mesoporous materials CMI-1 synthesized via an assembly of decaoxyethylene cetyl ether and TMOS
Blin, Jean-Luc; Léonard, Alexandre ULg; Su, Bao-Lian

in Chemistry of Materials (2001), 13(10), 3542-3553

Well-ordered spherical CMI-1 mesoporous materials with a hexagonal arrangement of channels, analogous to MCM-41, have been directly synthesized by variation of the weight percentage of decaoxyethylene ... [more ▼]

Well-ordered spherical CMI-1 mesoporous materials with a hexagonal arrangement of channels, analogous to MCM-41, have been directly synthesized by variation of the weight percentage of decaoxyethylene cetyl ether [C 16(EO) 10] in aqueous solution. XRD, TEM, SEM, and nitrogen adsorption-desorption results led us to propose two different synthesis pathways for surfactant concentrations higher and lower than 30 wt %, respectively. For samples obtained with an elevated surfactant concentration (>30 wt %), in addition to the possible perturbation induced by methanol released in low amount during the hydrolysis of TMOS, other factors such as the interactions of the silica source with hydrophilic chain heads of surfactant molecules should also disturb the preformed hexagonal micelle array, and disordered wormhole mesostructured materials (DWM), analogous to MSU, are obtained. For the synthesis with a C 16(EO) 10 concentration less than 30 wt %, a cooperative mechanism, which involves the polymerization of silica source and the interface interactions between the hydroxyl groups of silica source produced from the hydrolysis of TMOS and hydrophilic chain heads of surfactant molecules which are present in the single rod micelle form, has been evidenced, leading to well-ordered CMI-1 materials with hexagonal arrangement of their channels. [less ▲]

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See detailM. Migeotte
Biémont, Emile ULg

in Nouvelle Bibliographie Nationale, Académie Royale de Belgique (2001), 6

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See detailEntre symbolisme et avant-garde : le modernisme de Franz Hellens dans la première série du Disque Vert (1921-1925)
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2001), (20), 66-75

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See detailÀ la croisée du temps, de l’aspect et du mode: Le conjonctif en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (2001), (9), 293-329

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See detailComputational Study Of Lipid-Destabilizing Protein Fragments: Towards A Comprehensive View Of Tilted Peptides
Lins, Laurence ULg; Charloteaux, Benoît ULg; Thomas, Annick ULg et al

in Proteins-Structure Function and Genetics (2001), 44(4), 435-47

Tilted peptides are short sequence fragments (10-20 residues long) that possess an asymmetric hydrophobicity gradient along their sequence when they are helical. Due to this gradient, they adopt a tilted ... [more ▼]

Tilted peptides are short sequence fragments (10-20 residues long) that possess an asymmetric hydrophobicity gradient along their sequence when they are helical. Due to this gradient, they adopt a tilted orientation towards a single lipid/water interface and destabilize the lipids. We have detected those peptides in many different proteins with various functions. While being all tilted-oriented at a single lipid/water interface, no consensus sequence can be evidenced. In order to better understand the relationships between their lipid-destabilizing activity and their properties, we used IMPALA to classify the tilted peptides. This method allows the study of interactions between a peptide and a modeled lipid bilayer using simple restraint functions designed to mimic some of the membrane properties. We predict that tilted peptides have access to a wide conformational space in membranes, in contrast to transmembrane and amphipathic helices. In agreement with previous studies, we suggest that those metastable configurations could lead to the perturbation of the acyl chains organization and could be a general mechanism for lipid destabilization. Our results further suggest that tilted peptides fall into two classes: those from proteins acting on membrane behave differently than destabilizing fragments from interfacial proteins. While the former have equal access to the two layers of the membrane, the latter are confined within a single lipid layer. This could be in relation with the organization of lipid substrate on which the peptides physiologically act. [less ▲]

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See detailSr, Nd isotopes and geochemistry of the Bayuda Desert high-grade metamorphic basement (Sudan): An early Pan-African oceanic convergent margin, not the edge of the East Saharan ghost craton?
Küster, D.; Liégeois, Jean-Paul ULg

in Precambrian Research (2001), 109(1-2), 1-23

The high-grade metamorphic basement of the Bayuda Desert is situated at the inferred transition between the juvenile Neoproterozoic mainly greenschist facies Arabian-Nubian Shield (ANS) and the pre ... [more ▼]

The high-grade metamorphic basement of the Bayuda Desert is situated at the inferred transition between the juvenile Neoproterozoic mainly greenschist facies Arabian-Nubian Shield (ANS) and the pre-Neoproterozoic mainly amphibolite facies domain of the East Saharan Ghost Craton. New geochemical and Sr-Nd isotope data reveal that this basement in Bayuda constituted a Neoproterozoic oceanic convergent margin succession with limited and probably late input of old material. Within this series, garnet amphibolites and epidote-biotite gneisses have geochemical characteristics of HFSE-depleted tholeiitic basalts and low- to medium-K dacites and rhyodacites, indicating magmatism in an oceanic island arc or back-arc basin environment. This magmatism occurred at 806 ± 19 Ma (Sm-Nd 11 WR isochron), similar in age to arc magmatism in the ANS. Leucocratic gneisses, muscovite schists and garnet-biotite schists form the dominant meta-sedimentary rocks of the study area. They were primarily derived from two different sources: volcanogenic sediments from a Neoproterozoic island arc (TDM Nd model ages between 790 and 900 Ma) and terrigeneous sediments from an older continental source (TDM Nd model ages up to 2100 Ma). The volcanosedimentary succession was metamorphosed under amphibolite facies conditions prior to 670 Ma, probably at approximately 700 Ma. The high-grade metamorphism is related to a frontal collisional event that also produced syn-collisional peraluminous granites preserved as muscovite-biotite gneisses. Meta-igneous rocks from eastern Bayuda have εNd values at 806 Ma of + 5.2 ± 0.4, indicating a less depleted mantle source (crustal contamination can be excluded) than the neighbouring Gabgaba-Gebeit terrane (εNd, ca. + 7) from the Arabian-Nubian shield. Less depleted mantle source is also known at Jebel Moya to the south, and inside the Arabian-Nubian Shield to the southeast of Bayuda. Lithological and structural similarities (dominantly northeast striking foliation) with the Bayuda Desert succession occur in many parts of central and western Sudan, suggesting a comparable geodynamic evolution. It is proposed that a Neoproterozoic oceanic convergent margin (Bayuda type succession) collided at approximately 700 Ma to the northwest with the East Saharan ghost craton, whose easternmost limit must lie below or more to the west than previously thought. © 2000 Elsevier Science B.V. [less ▲]

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See detailRole of β-Oxidation Enzymes in γ-Decalactone Production by the Yeast Yarrowia lipolytica
Waché, Y.; Aguedo, Mario ULg; Choquet, A. et al

in Applied and Environmental Microbiology (2001), 67(12), 5700-5704

Some microorganisms can transform methyl ricinoleate into γ-decalactone, a valuable aroma compound, but yields of the bioconversion are low due to (i) incomplete conversion of ricinoleate (C18) to the C10 ... [more ▼]

Some microorganisms can transform methyl ricinoleate into γ-decalactone, a valuable aroma compound, but yields of the bioconversion are low due to (i) incomplete conversion of ricinoleate (C18) to the C10 precursor of γ-decalactone, (ii) accumulation of other lactones (3-hydroxy-γ-decalactone and 2- and 3-decen-4-olide), and (iii) γ-decalactone reconsumption. We evaluated acyl coenzyme A (acyl-CoA) oxidase activity (encoded by the POX1 through POX5 genes) in Yarrowia lipolytica in lactone accumulation and γ-decalactone reconsumption in POX mutants. Mutants with no acyl-CoA oxidase activity could not reconsume γ-decalactone, and mutants with a disruption of pox3, which encodes the short-chain acyl-CoA oxidase, reconsumed it more slowly. 3-Hydroxy-γ-decalactone accumulation during transformation of methyl ricinoleate suggests that, in wild-type strains, β-oxidation is controlled by 3-hydroxyacyl-CoA dehydrogenase. In mutants with low acyl-CoA oxidase activity, however, the acyl-CoA oxidase controls the β-oxidation flux. We also identified mutant strains that produced 26 times more γ-decalactone than the wild-type parents. [less ▲]

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See detailDe l'"Etat social actif" à la politique belge de l'emploi
Matagne, Geoffroy ULg

in Courrier Hebdomadaire du CRISP (2001), 1737-1738

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See detailEcologie du paysage: concepts, méthodes et applications (F. Burel, J. Baudry).
Bogaert, Jan ULg

in Landscape & Urban Planning (2001), 55(1), 70-72

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See detailDynamics of copepod faecal pellets in relation to a Phaeocystis dominated phytoplankton bloom: characteristics, production and flux
Frangoulis, Costa; Belkhiria, Sami; Goffart, Anne ULg et al

in Journal of Plankton Research (2001), 23(1), 75-88

Copepod faecal pellet characteristics and production were measured in spring 1995, 1996 and 1997 in the North Sea Southern Bight in order to define changes due to the development of the phytoplankton ... [more ▼]

Copepod faecal pellet characteristics and production were measured in spring 1995, 1996 and 1997 in the North Sea Southern Bight in order to define changes due to the development of the phytoplankton bloom. Changes were related to the succession from diatoms to a Phaeocystis sp. bloom. Mean monthly pellet production decreased during the Phaeocystis bloom development to 0.27 pellets ind. –1 h –1, approximately 80% lower than before and after the bloom. Although phytoplanktonic pigments showed significant differences between inshore and offshore stations, there was no such significant difference for faecal pellet production. Faecal pellet sinking-rate decreased from 100 to 70 m day –1 during the transition from a diatom- to a Phaeocystis-dominated bloom. This was due to a decrease in pellet density and/or a decrease of the pellet volume. These results supported the idea of lower feeding of copepods under Phaeocystis bloom conditions. As mean seasonal density of copepod faecal pellets was higher (1.37 g cm –3) than in other seas, accidental ingestion of sedimentary material as the cause of this high density is discussed. [less ▲]

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See detailOviposition preferences of Episyrphus balteatus.
Vanhaelen, Nicolas; Haubruge, Eric ULg; Gaspar, Charles ULg et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2001), 66(2a), 269-75

A crucial aspect of predator oviposition behaviour is host plant choice, especially in hoverflies where the newly hatched offspring are unable to move a great distance to search for the appropriate prey ... [more ▼]

A crucial aspect of predator oviposition behaviour is host plant choice, especially in hoverflies where the newly hatched offspring are unable to move a great distance to search for the appropriate prey. Such offspring must generally feed on the host plant aphids previously selected by the mother. Some factors involved in the selection of the oviposition site of Episyrphus balteatus De Geer include aphids associated to chemical stimuli, aphid colony size and host plant characteristics. Here we tested the hypothesis that there will not only be a rank order hierarchy of preference for aphid prey species reared on the same host plant but that a similar hierarchy of different host plant of one aphid species could be established. Therefore we compared the number of eggs laid on different combinations of host plant and aphid species. Vicia faba L., secondary metabolites free, Brassica napus L. and Sinapis alba L., containing low and high levels of glucosinolates respectively were used. The latter compounds are well known allelochemicals from Brassicaceae having a strong influence on specialist and generalist insects from both phytophagous and entomophagous levels. These experiments enhance the importance of tritrophic interactions in biological control of pests by underlining the host plant influence on aphidophagous predators, either directly or through the odours emitted by the phytophagous prey. [less ▲]

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See detailGap Filling Strategies For Long Term Energy Flux Data Sets
Falge, E.; Baldocchi, D.; Olson, R. et al

in Agricultural and Forest Meteorology (2001), 107(1),

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See detailAdaptive significance of facultative paedomorphosis in Triturus alpestris (Amphibia, Caudata): resource partitioning in an alpine lake
Denoël, Mathieu ULg; Joly, Pierre

in Freshwater Biology (2001), 46(10), 1387-1396

1. Facultative paedomorphosis is a polymorphism that has important evolutionary implications in promoting morphological differentiation and variation in habitat use. It occurs in several urodele species ... [more ▼]

1. Facultative paedomorphosis is a polymorphism that has important evolutionary implications in promoting morphological differentiation and variation in habitat use. It occurs in several urodele species throughout the world. Several hypotheses based on life-history theory have been proposed to explain the wide range of habitats in which facultative paedomorphosis occurs, suggesting multifactorial causes. 2. In harsh habitats, such as mountain lakes, paedomorphosis might promote niche partitioning between morphs. This hypothesis was tested by comparing micro-habitat use and diet of two coexisting morphs in an alpine lake. 3. Paedomorphs occupied all microhabitats in the lake while metamorphs occurred only along the shoreline or at the water surface. Paedomorphic newts were frequent in deep water, where they foraged mainly on plankton. Plankton was poorly exploited by metamorphic newts, which fed mainly on terrestrial insects. Difference between morphs in microhabitat use, and consequently in the diet, were consistent in both sexes and in juveniles. 4. In adults, the mass and energy value of stomach contents did not differ between morphs, suggesting a similar food availability in the habitats occupied. 5. This study indicates habitat partitioning between morphs involving dietary differences. Specific benefits and costs of each ontogenetic pathway may allow their coexistence in this deep and fishless lake. Paedomorphosis benefits individual newts by making new food resources available and presumably reducing competition at the shore of the lake. However, the proximate causes of such an ontogenetic switch remain unclear. [less ▲]

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See detailBooklist 2000
Pirenne, Christophe ULg

in Popular Music (2001), 20(3), 453-477

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