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See detailMore on generalized automatic sequences
Rigo, Michel ULg; Maes, Arnaud

in Journal of Automata, Languages and Combinatorics (2002), 7

We give some generalizations of $k$-automatic sequences replacing the $k$-ary system by an abstract numeration system on a regular language. We study some of the closure properties of these sequences and ... [more ▼]

We give some generalizations of $k$-automatic sequences replacing the $k$-ary system by an abstract numeration system on a regular language. We study some of the closure properties of these sequences and the possible extension to the multidimensional case or to infinite alphabets. The equivalence of these sequences and morphic predicates is given and the relationship to recognizability is also investigated. [less ▲]

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See detailImplications pour la communauté d'un meilleur contrôle de la pression artérielle
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (2002), 14(5), 186-190

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See detailThe plant pathogenesis-related PR-10 proteins
Elbez, Mounira; Kevers, Claire ULg; Hamdi, Saïd et al

in Acta Botanica Gallica : Bulletin de la Société Botanique de France (2002), 149(4), 415-444

The PR-10 protein family contains proteins related to pathogenesis and allergenic proteins. They are acidic proteins, with an intracellular localization, usually members of a multigene family and ... [more ▼]

The PR-10 protein family contains proteins related to pathogenesis and allergenic proteins. They are acidic proteins, with an intracellular localization, usually members of a multigene family and ubiquitous among plant kingdom. They contain a highly conserved motif, identified as a phosphate binding site. Even if the biological function of these proteins is still unknown, many indicators seem to favour the hypothesis of an RNAse activity. Moreover, one of them seems to be a cytokinin specific binding protein. Besides, PR-10 protein expression induction under cytokinin treatment was observed with the Catharanthus roseus CrPR-10a protein. Here, we present the evidence of a significative increase of endogenous cytokinin contents in leaves of transgenic Tobacco plants over-expressing the CrPR-10a protein. [less ▲]

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See detailLe complexe de l'intrus, ou l'effet de l'écart d'âge sur les membres d'une fratrie
Haxhe, Stéphanie ULg

in Dialogue : Recherches Cliniques et Sociologiques sur le Couple et la Famille (2002), 157(3), 107-116

This article deals with a study realized amongst siblings whose gaps in age were different. It attempts to bring out the whole importance of this variable to the development of the siblings, considered in ... [more ▼]

This article deals with a study realized amongst siblings whose gaps in age were different. It attempts to bring out the whole importance of this variable to the development of the siblings, considered in its « normality ». It notably points out how the intensity of the differences between full siblings of the same sex and with a small gap in age can be understood (indeed, sisters and brothers who are close in age and of the same sex, particularly amongst siblings of two, often appear to be very different and complementary). But this article also shows how the mark of the intrusion is different according to the age of the elder during this intrusion and how the impact of this variable (which is yet so little studied) seems to be significant in the individuals’development, on the narcissistic level as much as in the affects management. [less ▲]

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See detailContinuité de la délinquance entre l’adolescence et l’âge adulte
Born, Michel ULg

in Criminologie (2002), 35(1), 53-67

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See detailA case of hepatic alveolar echinococcosis contracted in Belgium
Delbecque, Katty ULg; Detry, Olivier ULg; Hayette, Marie-Pierre ULg et al

in Acta Gastro-Enterologica Belgica (2002), 65(1, Jan-Mar), 55-60

We report herein the case of a Belgian 76-year-oId woman who developed a hepatic tumour suspected to be a breast cancer metastasis. Radiological imaging and guided biopsies were not contributive. The ... [more ▼]

We report herein the case of a Belgian 76-year-oId woman who developed a hepatic tumour suspected to be a breast cancer metastasis. Radiological imaging and guided biopsies were not contributive. The patient underwent an explorative laparoscopy with frozen sections that did not provide further diagnosis, and an open left bisegmentectomy was performed during the same anaesthesia. Histopathological examination of the hepatic mass showed Echinococcus multilocularis metacestodes, demonstrating alveolar echinococcosis. As our patient denied any travel in foreign countries and has undergone regular abdominal ultrasonographies since her mastectomy, it is highly likely that this alveolar echinococcosis had been contracted in Belgium. If some imported cases may be seldom managed in Belgium, to our knowledge, this case is the first occurrence of alveolar echinococcosis contracted in Belgium. This report, added to the demonstration of E. multilocaris infection of 50% of red foxes in Southern Belgium, and the potential infection of domestic cats and dogs, should attract attention of the medical community on the possible outbreak of endemic alveolar echinococcosis in Belgium, and on the related public health concerns. [less ▲]

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See detailLittérature dialectale à Farciennes et Atlas linguistique de la Wallonie. De la géographie à la généricité
Droixhe, Daniel ULg; Vanwelkenhuyzen, Nadine ULg

in Revue Belge de Philologie et d'Histoire (2002), 80(3), 875-904

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See detailAsymmetric dihydroxylation of C,C double bonds using catalytic amounts of osmium tetroxide, selenides, and air
Krief, A.; Colaux, Catherine ULg

in Pure & Applied Chemistry (2002), 74(1), 107-113

Selenides, selenoxides, osmium tetroxide, and potassium osmate dihydrate are in equilibrium in aqueous tert-butanol containing potassium carbonate. We took advantage of this feature to withdraw the ... [more ▼]

Selenides, selenoxides, osmium tetroxide, and potassium osmate dihydrate are in equilibrium in aqueous tert-butanol containing potassium carbonate. We took advantage of this feature to withdraw the equilibrium in each of the two directions to produce allylalcohols from allylselenides and diols from olefins. The latter reaction performed in the presence of catalytic amounts of Cinchona alkaloids and osmium tetroxide allows the enantioselective dihydroxylation of C,C double bonds. [less ▲]

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See detailStatut et tendances des effectifs d’éléphants dans les aires protégées de l’Est du Burkina Faso
Bouché, Philippe ULg; Lungren, Clark; Ouédraogo, Léonard

in Pachyderm (2002), 32

Le Burkina Faso abrite l’effectif d’éléphants de savane le plus important de toute l’Afrique de l’Ouest, là où cette espèce jouit d’une protection intégrale. Un recensement aérien par échantillon a été ... [more ▼]

Le Burkina Faso abrite l’effectif d’éléphants de savane le plus important de toute l’Afrique de l’Ouest, là où cette espèce jouit d’une protection intégrale. Un recensement aérien par échantillon a été mené dans le sud-est du Burkina Faso en avril et mai 2000. L’effectif total moyen atteignait 1.743 ± 648 éléphants, ce qui constitue la plus grande population d’éléphants de savane en Afrique de l’Ouest. La moyenne des groupes observés était de: 5,42 (Erreur standard = 11,68 animaux) (1 à 32 individus / groupe). La distribution des éléphants enregistrée confirme largement la distribution enregistrée les années précédentes. [less ▲]

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See detailIdentification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal.
Braem, Caroline V; Kas, Koen; Meyen, Eva et al

in Journal of Biological Chemistry (2002), 277(22), 19673-8

The activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands. To gain more insight into the regulation of ... [more ▼]

The activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands. To gain more insight into the regulation of PLAG1 function, we searched for PLAG1-interacting proteins. Using the yeast two-hybrid system, we identified karyopherin alpha2 as a PLAG1-interacting protein. Physical interaction between PLAG1 and karyopherin alpha2 was confirmed by an in vitro glutathione S-transferase pull-down assay. Karyopherin alpha2 escorts proteins into the nucleus via interaction with a nuclear localization sequence (NLS) composed of short stretches of basic amino acids. Two putative NLSs were identified in PLAG1. The predicted NLS1 (KRKR) was essential for physical interaction with karyopherin alpha2 in glutathione S-transferase pull-down assay, and its mutation resulted in decreased nuclear import of PLAG1. Moreover, NLS1 was able to drive the nuclear import of the cytoplasmic protein beta-galactosidase. In contrast, predicted NLS2 of PLAG1 (KPRK) was not involved in karyopherin alpha2 binding nor in its nuclear import. The residual nuclear import of PLAG1 after mutation of the NLS1 was assigned to the zinc finger domain of PLAG1. These observations indicate that the nuclear import of PLAG1 is governed by its zinc finger domain and by NLS1, a karyopherin alpha2 recognition site. [less ▲]

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See detailApplication des barycentres en logique floue
Henry, Valérie ULg

in Mathématique et Pédagogie (2002), 139

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See detailMPEG: Standards for Digital Video MPEG Activities in Belgium
Van Droogenbroeck, Marc ULg

in Revue HF (2002), 2

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See detailLe patrimoine ferroviaire en miniature
Hoffsummer, Patrick ULg

in Cahiers de l'Urbanisme (Les) (2002)

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See detailHyperfine structure of neutral vanadium lines and livels
Lefèbvre, P.-H.; Garnir, Henri-Pierre ULg; Biémont, Emile ULg

in Physica Scripta (2002), 66

We have recorded hollow-cathode spectra of neutral vanadium by Fourier transform spectroscopy in the near infrared - visible region (9000-17 000 cm-1). 36 transitions showing hyperfine structure have been ... [more ▼]

We have recorded hollow-cathode spectra of neutral vanadium by Fourier transform spectroscopy in the near infrared - visible region (9000-17 000 cm-1). 36 transitions showing hyperfine structure have been analyzed, allowing us to deduce magnetic dipole constants for 27 levels belonging to the 3d44p and 3d34s4p configurations. For 22 of these levels no data were previously available. [less ▲]

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See detailEnquête sur les "contes" de Voltaire
Tilkin, Françoise ULg

in Cahiers Voltaire : Revue Annuelle de la Société Voltaire (2002), 1

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See detailLa Vierge comme protectrice des Pays-Bas méridionaux dans les livrets de pèlerinage marial au XVIIe siècle
Delfosse, Annick ULg

in Revue Belge de Philologie et d'Histoire (2002), 80(4), 1225-1241

Study of the dual symbolic function assigned by the Belgian pilgrimage booklets to the Virgin Mary in the 17th Century: the miraculous Madonnas worshiped in the shrines to cure the private individual’s ... [more ▼]

Study of the dual symbolic function assigned by the Belgian pilgrimage booklets to the Virgin Mary in the 17th Century: the miraculous Madonnas worshiped in the shrines to cure the private individual’s troubles are indeed also invoked to dress the wounds of a nation mangled and manhandled by the civic wars. [less ▲]

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See detailRecommendations for the design of clinical trials and the registration of drugs used in the treatment of asthma
Holgate, ST; Bousquet, J; Chung, KF et al

in International Journal of Pharmaceutical Medicine (2002), 16

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See detailLes cuirasses latéritiques et autres formations ferrugineuses tropicales : Exemple du Haut Katanga méridional
Alexandre, Jean ULg

in Annalen. Geologische Wetenschappen = Annales - Musée Royal de l'Afrique Centrale. Sciences Géologiques (2002), 107

In Southern High Katanga, the ferruginous formations such as iron duricrusts and stone lines with lateritic nodules show a diversity as broad as in Western Africa. Bauxites are nevertheless almost absent ... [more ▼]

In Southern High Katanga, the ferruginous formations such as iron duricrusts and stone lines with lateritic nodules show a diversity as broad as in Western Africa. Bauxites are nevertheless almost absent proving that, here, aluminium does not contribute to the genesis of duricrust, leaving iron as the only responsible. Among that wide diversity, the indurated sands form a special case because of their dual origin. Because of a large porosity favouring a fast iron penetration and fixation, some of the sandy concretions or duricrusts may have a short history and some of them may even be very recent. Nevertheless the others have a genesis that fits in with the general longer scheme. The most frequent type of laterite crust is also the most complex one. Its facies is both nodular and vermicular. Several agents and climatic phases are involved in its formation : • A first planation surface with wide-open valleys where the water table lies near the surface induces favourable circumstances for the next step; • In such circumstances, nodules are shaped in the mottled soil horizon. One exceptionally well-preserved site evidences the proximity between mottles (the nodules to be) and water table level at the end of the dry season; • A revival of erosion enhances river down cutting which in turn lowers the water table so that termites can reach the mottled horizon; • Nodules are mechanically concentrated by elimination of the non-indurated zones (relative accumulation): within the soil, by termites (on shaly rocks), at the surface by run off (often, on sandy rocks, unfavourable to termites activity); X • Finally the ran off extends to both types of rock and denudes the indurated zone; • A ferruginous coating forms on different substrates : upper laterite surface, internal joints, termite galleries as well as on any gravel at the soil surface. The coating lies unbroken from one object to the other but the outer surface is frequently eroded. The superficial coating could be a rock varnish formed by bacteria during a desertic period. The coating of galleries partly inhibits bioturbation because they collapse no more. The network of the strengthened galleries constitutes an internal skeleton reinforcing the laterite mantle; • With the return of a less severe climate, termites from below the laterite mantle again bring up material. The resulting upper fine deposit often exceeds 2 meter. All those processes imply important climatic variations : • A steppe vegetation with a scanty grass cover favouring run off and planation; • A relatively arid climate for the coatings formation; • A contrasted seasonal regime, not so different from the present day climate (six months dry season) for vertical erosion and intense termite activity. The weathering of rocky materials except for the iron impregnated ones (nodules, ferricretes and so on) requires a humid climate. This is happening nowadays but the more humid Quaternary phases were more effective in that respect. The characteristics of the outer coatings (thickness, colour, conservation state of the included quartz grains) allow us to identify four levels of ferricrete. Their succession is confirmed by the relative position of the coatings between them and by the correlated continental deposits. Because of their coatings, all those ferricretes are dated back to the Tertiary (because of the desertic climate needed for the formation of the rock varnish). Their levels overlook the Quaternary river terraces. The oldest ferricrete is quite different from the others. It shows neither nodules nor termite galleries. Its facies is thus very different from the nodular/vermiform of the three younger ones. It shows three facies, sometimes superimposed : pisolithic, massive or breccia-like. Moreover, the ferricrete of the corresponding level in West Africa contains bauxite. Its genesis is the result of a very different sequence of processes, some aggressive and linked to a humid climate with a great supply of iron and others resulting from more arid conditions producing the thick pisolith coatings. Ferruginous stone-lines present a wider variety of concretions than duricrast. Their upper part is the result of a concentration mainly by run off that occurred during several periods of the Quaternary. Cover loam is each time built up again by the termites from weathered rocks below the stone-line. The same phenomenon is seen on ferricretes. The soil profile where ferruginous formations can be seen consists of horizons of different ages. Weathering of saprolite and soil lifting are still active nowadays. Whereas some stone-line profiles are renewed at each Quaternary dry phase, the ferricrete profiles are build up during a long period of time extending from the Tertiary till now. A new definition of iron duricrast is proposed that is not based on weathering in depth or on the presence of aluminium [less ▲]

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See detailUse of a serum-free medium to produce in vitro Neospora caninum and Toxoplasma gondii tachyzoites on Vero cells
De Meerschman, F.; Rettigner, C.; Focant, Charles ULg et al

in Veterinary Research (2002), 33(2, Mar-Apr), 159-168

Neospora caninum and Toxoplasma gondii are cyst-forming coccidian parasites of human and veterinary clinical relevance. In vitro cultivation of the protozoans using Vero cells is usually performed in ... [more ▼]

Neospora caninum and Toxoplasma gondii are cyst-forming coccidian parasites of human and veterinary clinical relevance. In vitro cultivation of the protozoans using Vero cells is usually performed in order to produce antigenic materials. Quantitative and qualitative comparisons of Vero cells grown in RPMI medium supplemented either with foetal calf serum (FCS), horse serum (HS) or a specific serum-free additive (DefCell) were performed. A serum-free cell culture system used to propagate N. caninum (NC-1 isolate) and T. gondii tachyzoites (Rh stain) were compared with the other two cell culture systems. FCS supplemented media was found to be more effective than the others in promoting Vero cells and N. caninum tachyzoites. However, it was found unable to support adequate T. gondii tachyzoite proliferation. Vero cells, T. gondii and N. caninum tachyzoite production gave similar growth patterns with either HS or DefCell supplemented media. Defcell was considered as a good alternative to supplement culture medium. [less ▲]

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See detailEcosystem model (MODECOGeL) of the Ligurian Sea revisited. Seasonal and interannual variability due to atmospheric forcing
Lacroix, Geneviève; Grégoire, Marilaure ULg

in Journal of Marine Systems (2002), 37(4), 229-258

A one-dimensional coupled hydrodynamical–biological model, MODe`le d’ECOsyste`me du G.H.E.R. et du L.O.V. (MODECOGeL), of the water column is developed and applied to the Ligurian Sea (North Western ... [more ▼]

A one-dimensional coupled hydrodynamical–biological model, MODe`le d’ECOsyste`me du G.H.E.R. et du L.O.V. (MODECOGeL), of the water column is developed and applied to the Ligurian Sea (North Western Mediterranean). It is an extended and improved version of the model presented by Lacroix and Nival [J. Mar. Syst. 16 (1998) 23]. The hydrodynamic model is a 1D version of the 3D turbulent closure G.H.E.R. model, which takes into account momentum and heat surface fluxes computed from a real meteorological data set. The ecosystem model is defined by a nitrogen cycle described by 12 biological state variables including several plankton size classes and an explicit description of the bacterial loop. One data set coming from the FRONTAL missions is used to initialise and validate the model. To assess the impact of the interannual variability of the meteorological conditions on the ecosystem dynamics, the coupled model is run with 4-year real meteorological conditions (October 1984–September 1988). The model estimated percentages of the interannual variability of the annual mean biomass of phytoplankton, zooplankton and bacteria respectively of 31.0%, 16.2% and 16.3%. The ontribution of the zooplankton related to the total plankton biomass (phytoplankton, zooplankton and bacteria) has been found to be the most sensitive to the meteorological conditions variations (21%), followed by the phytoplankton (12%) and finally, by the bacteria (5%). The model estimated percentages of interannual variability of the annual gross primary production, the annual mean f-ratio and the annual bacterial production respectively of 27.9%, 18.5% and 13.4% although the interannual variability of the real winds conditions is only of 11.3%. Due to the more windy and less sunny conditions prevailing during the years ‘‘1985–1986’’ and ‘‘1986–1987’’, the annual primary production was found higher than during the years ‘‘1984–1985’’ and ‘‘1987–1988’’. The bacterial production is always greater than the primary production, showing the importance of the bacteria in such an oligotrophic environment. On a seasonal scale, the highest interannual variability of the primary production and the f-ratio is found in spring like for the wind intensity. [less ▲]

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See detailClassical and Bayesian inference in neuroimaging: Applications
Friston, Karl J; Glaser, Daniel E; Henson, Richard NA et al

in Neuroimage (2002), 16(2), 484-512

In Friston et al. ((2002) Neuroimage 16: 465-483) we introduced empirical Bayes as a potentially useful way to estimate and make inferences about effects in hierarchical models. In this paper we present a ... [more ▼]

In Friston et al. ((2002) Neuroimage 16: 465-483) we introduced empirical Bayes as a potentially useful way to estimate and make inferences about effects in hierarchical models. In this paper we present a series of models that exemplify the diversity of problems that can be addressed within this framework. In hierarchical linear observation models, both classical and empirical Bayesian approaches can be framed in terms of covariance component estimation (e.g., variance partitioning). To illustrate the use of the expectation-maximization (EM) algorithm in covariance component estimation we focus first on two important problems in fMRI: nonsphericity induced by (i) serial or temporal correlations among errors and (ii) variance components caused by the hierarchical nature of multisubject studies. In hierarchical observation models, variance components at higher levels can be used as constraints on the parameter estimates of lower levels. This enables the use of parametric empirical Bayesian (PEB) estimators, as distinct from classical maximum likelihood (ML) estimates. We develop this distinction to address: (i) The difference between response estimates based on ML and the conditional means from a Bayesian approach and the implications for estimates of intersubject variability. (ii) The relationship between fixed- and random-effect analyses. (iii) The specificity and sensitivity of Bayesian inference and, finally, (iv) the relative importance of the number of scans and subjects. The forgoing is concerned with within- and between-subject variability in multisubject hierarchical fMRI studies. In the second half of this paper we turn to Bayesian inference at the first (within-voxel) level, using PET data to show how priors can be derived from the (between-voxel) distribution of activations over the brain. This application uses exactly the same ideas and formalism but, in this instance, the second level is provided by observations over voxels as opposed to subjects. The ensuing posterior probability maps (PPMs) have enhanced anatomical precision and greater face validity, in relation to underlying anatomy. Furthermore, in comparison to conventional SPMs they are not confounded by the multiple comparison problem that, in a classical context, dictates high thresholds and low sensitivity. We conclude with some general comments on Bayesian approaches to image analysis and on some unresolved issues. [less ▲]

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See detailInfluence of Sieve Trays on the Mass Transfer of Single Drops
Henschke, Martin; Pfennig, Andreas ULg

in AIChE Journal (2002), 48(2), 227-234

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See detailEffets perturbateurs endocriniens des pesticides organochlorés
Charlier, Corinne ULg; Plomteux, Guy ULg

in Acta Clinica Belgica. Supplementum (2002), (1), 2-7

Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism ... [more ▼]

Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism, or to compete with estradiol for binding to the estrogen receptor, it may be possible that these products affect the risk of developing impaired fertility, precocious puberty or some kinds of cancer in man. Le plus ancien récit de lutte contre la pollution remonte à une légende indienne racontant que la divinité Sing-bonga était incommodée par les émanations des fours dans lesquels les Asuras fondaient leurs métaux (1). Evidemment depuis, la problématique n–a cessé de s–accroître et la contamination de la Terre par de nombreux polluants est devenue aujourd–hui un problème majeur de notre Société. La protection de notre environnement est une question capitale qui doit être respectée malgré la pression économique actuelle et qui ne cessera de croître au cours des prochaines années même si l–identification objective et indiscutable de ce qui est essentiel – donc devant être prioritairement garanti sur la planète – est difficile à cerner (2). « Un oiseau en mauvais état ne pond pas de bons oeufs » disait un proverbe grec. Mais ce n–est qu–à partir de la seconde moitié du XXème siècle que les toxicologues ont commencé à identifier les effets qu–avaient entraînés à l–échelle mondiale les pollutions émises aux XIXème siècle sur la faune sauvage et sur le cheptel (3). L–histoire contemporaine des pesticides industriels commence vers 1874 (synthèse des organochlorés) et se poursuit tout au long de ces 2 siècles en passant par la synthèse des organophosphorés (1950), des carbamates (1970) et des pyréthroïdes (1975) (4). Le dichlorodiphényltrichloroéthane (DDT) a été synthétisé pour la première fois par un étudiant en cours de préparation de sa thèse de doctorat : Othmer Zeidler. La production, reprise par les entreprises F.Mayo puis par la Geigy Co. a d–abord intéressé l–armée, puis l–agriculture. Dès la fin de la 2ème guerre mondiale, des mises en garde furent lancées à propos des effets nocifs du produit (4). Un déclin des populations de grives, d–aigles chauves, d–orfaies et de mammifères consommateurs de poissons fut constaté à partir des années 50 et dénoncé par Rachel Carson dans son célèbre appel du « Silent Spring » de 1962. Bien qu–il soit interdit en Occident depuis les années 70, ce produit a été tellement utilisé et présente une rémanence si longue qu–une contamination ubiquitaire existe aujourd–hui encore. De plus, ce produit continue à être produit aux USA pour être utilisé à des fins de démoustification dans les pays en voie de développement. Il en va de même de l–Hexachlorobenzène (HCB), un autre organochloré dont l–usage est interdit sous nos latitudes, mais reste fréquent dans d–autres pays. Ces deux exemples indiquent que le problème de la contamination continue à nous concerner, même pour des produits dont l–usage est aujourd–hui strictement réglementé ou interdit. Des effets sur la faune semblent encore actuellement devoir être attribués à ces produits. La diminution de la population des phoques dans la mer de Wadden pourrait être due à la forte contamination en composants organochlorés des poissons dont ces phoques se nourrissent (5). Exposé au DDT et à son métabolite dichlorodiphenyldichloroéthylène (DDE), le Seratherodon mossambicus présente une réduction de la sécrétion de cortisol par une action toxique cytospécifique sur l–axe hypothalamo-hypophysaire (6). Des travaux récents ont montré que le DDT et le DDE se lient chez les oiseaux et les mammifères au moyen de liaisons covalentes aux cellules de la zona fasciculata - homologue du tissu interrénal du poisson - induisant des microhémorragies. Cette « défaillance » cortisolique peut s–accompagner d–une perturbation du métabolisme glucidique et notamment d–un taux élevé de glycogène hépatique (7). Les pesticides organochlorés (DDT, DDE) entraînent également des perturbations d–ordre métabolique chez certaines espèces d–oiseaux, notamment le faucon pèlerin en Grande Bretagne et les oiseaux piscivores des grands lacs nord américains où l–on a constaté au cours des années 1960 que leur reproduction était menacée et qu–une des manifestations les plus évidentes des perturbations observées était le taux élevé de malformations (8). Des mortalités élevées de poissons ou de coquillages ont été rapportées dans des élevages situés à proximité des zones d–épandage de pesticides organophosphorés et de carbamates. En 1991, la dispersion aérienne de fenitrothion dans le but de provoquer la démoustication en Languedoc a été à l–origine de la perte de plusieurs tonnes de crevettes japonaises. L–utilisation de trichlorfon et de dichlorvos comme antiparasitaires dans des fermes d–élevages de saumons a provoqué des épisodes de mortalité importante (9). [less ▲]

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See detailCross Border Health Care : an Analysis of Recent ECJ Rulings
Fecher-Bourgeois, Fabienne ULg; Paulus, Aggie; Evers, Sylvia et al

in European Journal of Law and Economics (2002), 14

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See detailCréation d'un site Internet d'Evidence-Based Medicine.
Delvenne, Catherine ULg; Pasleau, Françoise ULg

in Médi-Sphère (2002), (67), 41-43

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See detailEffect of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice.
Tibor, Anne; Wansard, Valerie; Bielartz, Valery et al

in Infection and Immunity (2002), 70(10), 5540-6

The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and ... [more ▼]

The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new family of outer membrane proteins specifically encountered in the family RHIZOBIACEAE: We evaluated the impact of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. The omp10 mutant was dramatically attenuated for survival in mice and was defective for growth in minimal medium but was not impaired in intracellular growth in vitro, nor does it display clear modification of the outer membrane properties. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B. abortus. [less ▲]

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See detailComposite structures optimization using sequential convex programming
Bruyneel, Michaël ULg; Fleury, Claude ULg

in Advances in Engineering Software (2002), 33(7-10), 697-711

The design of composite structures is considered here. The approximation concepts approach is used to solve the optimization problem. The convex approximations of the MMA family are briefly described ... [more ▼]

The design of composite structures is considered here. The approximation concepts approach is used to solve the optimization problem. The convex approximations of the MMA family are briefly described. Several modifications of these approximations are presented. They are now based on gradient information at two successive iterations, avoiding the use of the expensive second-order derivatives. A two-point fitting scheme is also described, where the function value at the preceding design point is used to improve the approximation. Numerical examples compare these new purely non-monotonous schemes to the existing ones for the selection of optimal fibers orientations in laminates. It is shown how these two-point based approximations are well adapted to the problem and can improve the optimization task, leading to reasonable computational efforts. A procedure is also derived for considering simultaneously monotonous and non-monotonous structural behaviors. The resulting generalized approximation scheme is well suited for the optimization of composite structures when both plies thickness and fibers orientations are considered as design variables. It is concluded that the newly developed approximation schemes of the MMA family are reliable for composite structures optimization. All the studied approximations are convex and separable: the optimization problem can then be solved using a dual approach. (C) 2002 Civil-Comp Ltd and Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailQuelques considérations techniques sur la construction, les transformations et l'état matériel de la tour valenciennoise, à Mons
Houbart, Claudine ULg

in Mémoires et Publications de la Société des Sciences, des Arts et des Lettres du Hainaut (2002), CI

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See detailGlobal democratic consensus on neuropathological disease criteria.
Achim, Cristian; Auer, Roland; Bergeron, Catherine et al

in Lancet Neurology (2002), 1(6), 340

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See detailLa précession du plan d'oscillation du pendule de Foucault : une approche géométrique intuitive
De Rop, Yves ULg; Moreau, Olivier

in Revue des Questions Scientifiques (2002), 173(3), 261-276

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See detailImaging downward granitic magma transport in the Rogaland Igneous Complex, SW norway
Bolle, Olivier ULg; Trindade, Ricardo I.F.; Bouchez, Jean-Luc et al

in Terra Nova (2002), 14(2), 87-92

Combining geological mapping and petrological, structural and geophysical (gravity and seismic) data already available for the late Proterozoic Rogaland Igneous Complex of Norway allows the 3D shape of ... [more ▼]

Combining geological mapping and petrological, structural and geophysical (gravity and seismic) data already available for the late Proterozoic Rogaland Igneous Complex of Norway allows the 3D shape of the Bjerkreim-Sokndal layered intrusion to be modelled as a thick cumulate series capped by massive granitic rocks. Using the latter data, along with the spectacular convergent linear flow pattern that covers both the cumulates and the felsic rocks of this chamber, evidence is presented to show that the granitic material was down-dragged through the sinking of its high-density mafic floor into lower density anorthosites and granulitic gneisses. This example illustrates that downward gravity-driven flows of rocks were active, in addition to upward flows, in the building of the early crust up to late-Proterozoic times, helping to explain the geochemical and structural complexities of the old crust. [less ▲]

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See detailPharma clinics. Le médicament du mois. L'imiquimod (Aldara): un immunomodulateur pour la peau.
Hermanns-Lê, Trinh ULg; Nikkels, Arjen ULg; Uhoda, Isabelle et al

in Revue Médicale de Liège (2002), 57(2), 116-8

Imiquimod is the first drug of a new therapeutic class encompassing cutaneous immune response modifiers. This molecule induces the synthesis and release of macrophage-related cytokines. It boosts some ... [more ▼]

Imiquimod is the first drug of a new therapeutic class encompassing cutaneous immune response modifiers. This molecule induces the synthesis and release of macrophage-related cytokines. It boosts some local immune responses. These properties are used to treat cutaneous viral condylomas. Other prospective therapeutic goals are presently scrutinized. [less ▲]

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See detailLa colibacillose aviaire
Stordeur, Philippe; Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2002), 146(1, FEB-MAR), 11-18

The avian pathogenic E. coli strains, although considered by almost like opportunist pathogen, represent actually one of the most important cause of economic losses in the poultry sector and is one of the ... [more ▼]

The avian pathogenic E. coli strains, although considered by almost like opportunist pathogen, represent actually one of the most important cause of economic losses in the poultry sector and is one of the most frequent cause of carcase rejection in the slaughter house. Colibacillosis, which the major way of penetration is the respiratory tract, affect essentially broilers and give variable lesions and manifestations in function of the age of the animals. Actually, some virulence factors have been studied and associated with avian pathogenic E. coli strains : P and F1 fimbriae, hemagglutination, serum resistance, aerobactin system. Recent studies have also showed that other virulence factors (F17 and Afa adhesins) were also present in the avian pathogenic E. coli, but their rule in the pathogenicity must to be established. Because of the diversity of virulence factors and the little of knowledge about us, no vaccine is actually available to protect efficacely poultries against colibacillosis. Thus, the antibiotherapy based on a good diagnostic and a good prevention remained the only things to do in order to overcome the disease, despite the augmentation of antibiotics resistance and the risk of transferring to humans. [less ▲]

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See detailFast F-18 FDG synthesis by alkaline hydrolysis on a low polarity solid phase supports
Lemaire, Christian ULg; Damhaut, P.; Lauricella, Benjamino ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2002), 45(5), 435-447

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose ... [more ▼]

The synthesis of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has been simplified by the use of a tC18 Sep Pak cartridge to effect purification and hydrolysis of the tetraacetylated [18F]fluoro-glucose compound ([18F]TAG). After radiolabelling, this derivative was trapped on a solid phase extraction (SPE) cartridge and the residual reaction solvent (CH3CN), reagents (K222, K2CO3,) and by-products removed by washing the support with water. After this cleaning step, the acetyl groups were cleaved on the same tC18 column using 2N sodium hydroxide. This fast reaction proceeded near quantitatively (>98%) at room temperature in less than 2 min. The [18F]FDG was then recovered with a small amount of water, neutralized with a slight excess of 2N hydrochloric acid, buffered for pH with a citrate solution and finally purified on a neutral alumina oxide and a second tC18 column. After filtration, the radiochemical yield of this [18F]FDG isotonic solution after more than 100 production runs was found to be very reliable and reproducible (70±6% decay corrected). The synthesis time was about 22 min. Quality controls showed that the radiochemical purity was higher than 98% and in any case no [18F]FDM was detected. Only traces of 2-chloro-2-deoxy-glucose (ClDG) were found in the final sample (64±9 g/ batch of 16 ml). [18F]FDG specific activity averaged between 1 and 20 Ci/µmol (EOS). No evaporation and use of ion retardation resin (AG11A8) are required. Moreover, this new approach is suitable for complete remote operation using available single use medical components. Copyright © 2002 John Wiley [less ▲]

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See detailSpectral and crystallographic study of pyridinic analogues of nimesulide : determination of the active form of methanesulfonamides as COX-2 selective inhibitors
Julémont, F.; de Leval, X.; Michaux, C. et al

in Journal of Medicinal Chemistry (2002), 45

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See detailQu'est-ce que l'expérience corporelle des patientes souffrant d'anorexie mentale ? Une étude empirique
Mayers, I.; Bragard, Isabelle ULg; Demoulin, Catherine et al

in Revue Francophone de Clinique Comportementale et Cognitive (2002), 7(3), 5-13

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See detailDevelopment of GEQUAC as a new group contribution method for strongly non-ideal mixtures
Ehlker, Gerhard H; Pfennig, Andreas ULg

in Fluid Phase Equilibria (2002), 203((1-2)), 53-69

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See detailMerits of the multivariate Dale model in genetic association studies
Van Steen, Kristel ULg; Molenberghs, G.; Tahri, N.

in Genetic Epidemiology (2002), 23

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See detailMass transfer by free and forced convection from single spherical liquid drops
Waheed, M Adekojo; Henschke, Martin; Pfennig, Andreas ULg

in International Journal of Heat & Mass Transfer (2002), 45(22), 4507-4514

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See detailFeasibility of a Walloon test-day model and study of its potential as tool for selection and management
Auvray, B.; Gengler, Nicolas ULg

in Interbull Bulletin (2002), 29

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See detailLes souches pathogènes d'Escherichia coli chez les chiens et les chats : IV) Discussion générale
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2002), 146(4, AUG-SEP), 219

This manuscript reviews the current knowledge on the main classes of pathogenic Escherichia coli in dogs and cats: type 1 necrotoxigenic strains (NTEC1), adhesin-positive strains (AdEC), enteropathogenic ... [more ▼]

This manuscript reviews the current knowledge on the main classes of pathogenic Escherichia coli in dogs and cats: type 1 necrotoxigenic strains (NTEC1), adhesin-positive strains (AdEC), enteropathogenic strains (EPEC) and enterotoxigenic strains (ETEC). They represent primary or secondary (to other bacterial, parasitic and/or viral infections) infectious agents. NTEC1 and AdEC are the most frequent and are responsible for intestinal, urinary tract and invasive infections, while EPEC and ETEC limit their infections to the intestinal tract. ETEC are the less frequent but EPEC are more and more often observed. The specific virulence factors and other properties of these pathogenic E. coli strains are similar to those of their bovine, human and porcine counterparts, for their identity and their genetic determinism. This similarity allows the use of an identical approach in their diagnosis and typing. But for some NTEC1, AdEC and EPEC strains the similarity is so close that it also raises the question of their zoonotic potential, though there is up to now no epidemiological evidence of such cross contamination of man by canine or feline pathogenic E. coli (or vice versa). [less ▲]

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See detailPoesia dell’alto medioevo europeo : manoscritti, lingua e musica dei ritmi latini
Moreno, Paola ULg

in Scriptorium (2002), 267

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See detailPhylogéographie mitochondriale du mulot sylvestre (Apodemus sylvaticus) dans la région paléarctique occidentale
Michaux, Johan ULg; Magnanou, Elodie; Nieberding, Caroline et al

in Biosystema, Systématique et biogéographie (2002), 20

We have sequenced 965 base pairs of the mitochondrial DNA cytochrome b from 102 woodmice (Apodemus sylvaticus) samples collected from 40 European localities. The aims of the study were to answer the ... [more ▼]

We have sequenced 965 base pairs of the mitochondrial DNA cytochrome b from 102 woodmice (Apodemus sylvaticus) samples collected from 40 European localities. The aims of the study were to answer the following questions: i) Did the Mediterranean peninsulas play a role as a refuge for small mammals? ii) Is the genetic variability of a small mammal like A. sylvaticus higher in the Mediterranean regions as compared with northern Europe? iii)Is it possible to find patterns of postglacial colonisation of Europe other than those presently recognised ? Sequence data were analysed using Distance and Maximum Parsimony phylogenetic reconstruction methods. A minimum spanning network was also calculated. Population genetic structure was determined by analysis of molecular variance (AMOVA). A "mismatch distribution" analysis was also performed to estimate the patterns of expansion. The results provide a clear picture of the impact of Quaternary glaciations on the genetic and geographic structure of the woodmouse. Analyses indicate a higher genetic variability for the woodmouse in the Mediterranean peninsulas as compared to northern Europe and the role of these peninsulas as refuge regions for small mammals. A new pattern of postglacial colonisation is also proposed where the Iberian and southern France refuge populations colonised almost all the European regions. The Sicilian population appears to be highly differentiated and highly variable. This result emphasises the importance of this island as a "hot spot" for the intraspecific genetic diversity of the woodmouse. Finally, populations of this species in North Africa originated from south-western Europe and are probably the result of a recent anthropogenic introduction. [less ▲]

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See detailElectron localization: Band-by-band decomposition and application to oxides
Veithen, M.; Gonze, X.; Ghosez, Philippe ULg

in Physical Review. B, Condensed Matter and Materials Physics (2002), 66

Using a plane-wave pseudopotential approach to density functional theory we investigate the electron localization length in various oxides. For this purpose, we first set up a theory of the band-by-band ... [more ▼]

Using a plane-wave pseudopotential approach to density functional theory we investigate the electron localization length in various oxides. For this purpose, we first set up a theory of the band-by-band decomposition of this quantity, more complex than the decomposition of the spontaneous polarization (a related concept), because of the interband coupling. We show its interpretation in terms of Wannier functions and clarify the effect of the pseudopotential approximation. We treat the case of different oxides: BaO, alpha-PbO, BaTiO3, and PbTiO3. We also investigate the variation of the localization tensor during the ferroelectric phase transitions of BaTiO3 as well as its relationship with the Born effective charges. [less ▲]

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See detailCritères et indicateurs : les initiatives gabonaises
O'Heix, Bruno-Charles; Doucet, Jean-Louis ULg; Ondo, Rose et al

in Bois et Forêts des Tropiques (2002), 271(1), 79-88

Près de deux décennies après les premières discussions sur le concept de durabilité, le processus de mise en place de la gestion durable des forêts de production est en voie de concrétisation en zone ... [more ▼]

Près de deux décennies après les premières discussions sur le concept de durabilité, le processus de mise en place de la gestion durable des forêts de production est en voie de concrétisation en zone tropicale. Les consensus politiques et scientifiques s’ébauchent aux échelons régionaux comme nationaux. Un certain optimisme est donc de mise, même si de nombreuses questions demeurent en suspens et si les objectifs (globaux et spécifiques) demeurent encore peu lisibles. Les difficultés liées aux intérêts macro- et microéconomiques que représente la forêt sont encore renforcées par la question de la certification des bois issus de la gestion durable. Les initiatives pour la définition de normes de certification, outre leur intérêt potentiel en termes de financement de la gestion durable des forêts (GDF), ont néanmoins largement contribué à l’avancée des méthodes et des processus de développement des critères et des indicateurs (C & I) pour la mesure et le suivi de la gestion durable. De nombreux ensembles de C & I, depuis une utilisation régionale jusqu’à un usage par des unités de gestion forestière (UGF), ont vu le jour, y compris dans le bassin du Congo où aucune « gestion durable » n’a encore été validée par une certification commerciale. À ce jour, de par l’engagement du gouvernement et les initiatives précoces de certains opérateurs forestiers privés, le Gabon apparaît comme un modèle pour la région du bassin du Congo. [less ▲]

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See detailLa vaccination contre la fièvre aphteuse : perspectives
Thiry, Etienne ULg; De Clercq, K.; Saegerman, Claude ULg et al

in Bulletin des Groupements Techniques Vétérinaires (2002), 14

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See detailPierre Bourdieu: une sociologie de la désespérance/ paradigme économique, lutte de pouvoir et "violence inerte"
Robert, Jocelyne ULg

in Revue de l'Institut de Sociologie (2002), 1-4

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See detailLe vol du cheval sacré
Swennen, Philippe ULg

in Acta Orientalia Belgica (2002), XVI

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See detailCryopreservation For The Elimination Of Cucumber Mosaic And Banana Streak Viruses From Banana (Musa Spp.)
Helliot, Bertrand; Panis, B.; Poumay, Y. et al

in Plant Cell Reports (2002), 20(12), 1117-1122

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See detailHeat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice.
McMillan, D Randy; Christians, Elisabeth; Forster, Michael et al

in Molecular & Cellular Biology (2002), 22(22), 8005-14

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress ... [more ▼]

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the functions of HSF2 and HSF4 are less clear. Based on its developmental profile of expression, it was hypothesized that HSF2 may play an essential role in brain and heart development, spermatogenesis, and erythroid differentiation. To directly assess this hypothesis and better understand the underlying mechanisms that require HSF2, we generated Hsf2 knockout mice. Here, we report that Hsf2(-/-) mice are viable and fertile and exhibit normal life span and behavioral functions. We conclude that HSF2, most probably because its physiological roles are integrated into a redundant network of gene regulation and function, is dispensable for normal development, fertility, and postnatal psychomotor function. [less ▲]

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See detailL’authenticité iconographique des portails occidentaux de la cathédrale de Strasbourg
Van den Bossche, Benoît ULg

in Bulletin de la Cathédrale de Strasbourg (2002), 15

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See detailLes acteurs et les enjeux au coeur de l'évaluation
Vandoorne, Chantal ULg

in Education santé (2002), 173(173), 9-11

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See detailEnergy Balance Closure At Fluxnet Sites
Wilson, K.; Goldstein, A.; Falge, E. et al

in Agricultural and Forest Meteorology (2002), 113(1-4),

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See detailLe parquet fédéral est arrivé : plus-value pour le ministère public ?
Masset, Adrien ULg

in Journal des Tribunaux (2002), 6043(2002), 121-129

La loi du 21 juin 2001 modifiant certaines dispositions en ce qui concerne le parquet fédéral rend celui-ci effectif à partir du 21 mai 2002. Cette nouvelle institution au sein du ministère public a ... [more ▼]

La loi du 21 juin 2001 modifiant certaines dispositions en ce qui concerne le parquet fédéral rend celui-ci effectif à partir du 21 mai 2002. Cette nouvelle institution au sein du ministère public a suscité de vives critiques de la part du Conseil d’Etat, du collège des procureurs généraux, du conseil des procureurs du Roi et du Conseil supérieur de la justice. Est spécialement critiquée l’imprécision avec laquelle le procureur fédéral et les magistrats fédéraux pourront exercer l’action publique dans une série de dossiers aux contours incertains, en lieu et place des procureurs du Roi locaux; les risques de conflits et de ponctions systématiques dans les forces vives des parquets locaux inquiètent, de même que l’indépendance du procureur fédéral. [less ▲]

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See detailRecurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability.
Paquet, Philippe ULg; Jacob, Eric; Damas, Pierre ULg et al

in Critical Care Medicine (2002), 30(11), 2580-3

OBJECTIVE: A series of antibiotics may be responsible for toxic epidermal necrolysis. We report two successive episodes of toxic epidermal necrolysis in the same patient. Drug imputability criteria ... [more ▼]

OBJECTIVE: A series of antibiotics may be responsible for toxic epidermal necrolysis. We report two successive episodes of toxic epidermal necrolysis in the same patient. Drug imputability criteria designate a cross-reactivity between two antibiotics of different chemical classes but sharing the beta-lactam ring in common. DESIGN: Descriptive case report and review of the literature. SETTING: Medical intensive care unit in a university medical center. PATIENT AND MAIN RESULTS: A 75-yr-old woman developed a first episode of toxic epidermal necrolysis (involving 40% of the body surface) after intake of cefotaxime, a third-generation cephalosporin. Perfusions of high-dose immunoglobulins rapidly improved the lesions, followed by partial reepithelialization in 5 days. Sepsis required the administration of meropenem, which is a carbapenem antibiotic. The epidermal destruction immediately recurred, with extension to previously uninvolved skin areas and fatal consequences. CONCLUSIONS: The beta-lactam ring present in cephalosporins and carbapenems represents the putative chemical structure responsible for the presently reported cross-reactivity to two antibiotics of different classes. Drugs having any chemical similarity to the initial culprit compound should be strictly avoided when possible in the management of toxic epidermal necrolysis. [less ▲]

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See detailExpression of the zinc finger Egr1 gene during zebrafish embryonic development
Close, Renaud; Toro, Sabrina; Martial, Joseph ULg et al

in Mechanisms of Development (2002), 118(1-2), 269-72

Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression ... [more ▼]

Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization. Egr1 mRNA is first detected in adaxial cells in the presomitic mesoderm between 11 and 20 h post-fertilization (hpf), spanning the 4-24 somite stages. Later, Egr1 expression is observed only in specific brain areas, starting at 21 hpf and subsequently increasing in distinct domains of the central nervous system, e.g. in the telencephalon, diencephalon and hypothalamus. Between 24 and 48 hpf, Egr1 is expressed in specific domains of the hypothalamus, mesencephalon, tegmentum, pharynx, retina, otic vesicle and heart. [less ▲]

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See detailCompte-rendu de L. Blasucci, "Per una tipologia degli esordi nei canti danteschi"
Benzoni, Pietro ULg

in Stilistica e metrica (2002), II(2), 318-319

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See detailDNA sequences coding for the F18 fimbriae and AIDA adhesin are localized on the same plasmid in Escherichia coli isolates from piglets
Mainil, Jacques ULg; Jacquemin, E.; Pohl, P. et al

in Veterinary Microbiology (2002), 86

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See detailCD40 engagement enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 expression: Possible involvement in allergic inflammation.
Bureau, Fabrice ULg; Seumois, Gregory; Jaspar, Fabrice et al

in Journal of Allergy and Clinical Immunology (The) (2002), 110(3), 443-9

BACKGROUND: CD40 engagement enhances eosinophil survival, suggesting a role for this receptor in the development of eosinophilia. OBJECTIVE: We examined whether CD40 enhances eosinophil survival by ... [more ▼]

BACKGROUND: CD40 engagement enhances eosinophil survival, suggesting a role for this receptor in the development of eosinophilia. OBJECTIVE: We examined whether CD40 enhances eosinophil survival by inducing the expression of antiapoptotic proteins. Three members of the inhibitor of apoptosis protein (IAP) family, namely cellular (c)-IAP1, c-IAP2, and XIAP, and 2 antiapoptotic proteins of the Bcl-2 family, namely Bcl-x(L) and Bfl-1/A1, were investigated. METHODS: Blood and sputum were obtained from healthy subjects and atopic asthmatic patients. Blood eosinophils were isolated by means of magnetic selection. Expression of CD40, IAPs, and Bcl-2 proteins was investigated by using flow cytometry, immunoblotting, or both. CD40 stimulation was achieved with agonistic antibodies or soluble ligands. Apoptosis was assessed by staining with propidium iodide and FITC-conjugated annexin-V. c-IAP2 expression was inhibited with antisense oligonucleotides. RESULTS: Freshly isolated eosinophils from healthy and asthmatic patients did not express CD40. Conversely, eosinophils expressed CD40 spontaneously when cultured for 48 hours. At this time point, CD40 stimulation significantly delayed eosinophil apoptosis. Inhibition of eosinophil apoptosis was accompanied by induction of c-IAP2 but not c-IAP1, XIAP, Bcl-x(L), or Bfl-1/A1 expression. Antisense knockdown of c-iap2 abolished CD40-induced enhancement of eosinophil survival. Sputum cells from asthmatic patients, unlike those from healthy subjects, substantially expressed CD40 and c-IAP2. Moreover, a strong correlation was found between the percentage of eosinophils in the sputum from asthmatic patients and the sputum level of CD40 and c-IAP2 expression. CONCLUSION: The results demonstrate that CD40 engagement enhances eosinophil survival through induction of c-IAP2 expression and suggest a role for this mechanism in allergic inflammation. [less ▲]

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See detailLa conformation bouchère des agneaux. Etude d'après la variabilité génétique entre races
Laville, E.; Bouix, J.; Sayd, T. et al

in INRA Productions Animales (2002), 15(1), 53-66

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See detailLong-pulsed ruby laser-assisted hair removal in male-to-female transsexuals.
Paquet, Philippe ULg; Fumal, I.; Pierard, Claudine ULg et al

in Journal of Cosmetic Dermatology (2002), 1(1), 8-12

BACKGROUND: Unwanted male-pattern pilosity is a heavy psychological burden and can cause distress for male-to-female transsexuals. Orchidectomy and oestrogen supplementation combined with antiandrogens ... [more ▼]

BACKGROUND: Unwanted male-pattern pilosity is a heavy psychological burden and can cause distress for male-to-female transsexuals. Orchidectomy and oestrogen supplementation combined with antiandrogens fail to make hair disappear. AIMS: To study the effect of long-pulsed ruby laser treatment. RESULTS: Hair density was successfully abated on the beard and chest of three male-to-female transsexuals. A lingering effect over 6 months with a 50-90% hair density reduction was obtained. CONCLUSION: Photothermolysis using the long-pulsed ruby laser is a promising, well-tolerated method of hair removal in male-to-female transsexuals under oestrogen supplementation and antiandrogens. [less ▲]

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See detailExpression of TGF-betas and their receptors is differentially modulated by reactive oxygen species and nitric oxide in human articular chondrocytes.
Ayache, N.; Boumediene, K.; Mathy, Marianne ULg et al

in Osteoarthritis and Cartilage (2002), 10(5), 344-52

OBJECTIVES: To study the effects exerted by two antioxidants, N-monomethyl-L-arginine (L-NMMA), as an inhibitor of nitric oxide (NO) synthesis, and N-acetylcysteine (NAC), a reactive oxygen species (ROS ... [more ▼]

OBJECTIVES: To study the effects exerted by two antioxidants, N-monomethyl-L-arginine (L-NMMA), as an inhibitor of nitric oxide (NO) synthesis, and N-acetylcysteine (NAC), a reactive oxygen species (ROS) scavenger, on the expression of the major growth factor involved in cartilage repair, TGF-beta, under the three isoforms beta1, beta2 and beta3, and the receptors I and II of this factor, using lipopolysaccharide (LPS)-treated human chondrocytes in culture. METHODS: Suspension cultures of human chondrocytes derived from the knee of osteoarthritic patients were treated for 48 h with lipopolysaccharide (LPS) (10 microg/ml), L-NMMA (0.5 mM) or NAC (1 mM). Nitrite levels were assayed on the culture media using the Griess spectrophotometric method. After total RNA extraction, the expression of inducible NO synthase (iNOS), TGF-beta1, TGF-beta2, TGF-beta3, TGF-beta receptors I and II, was determined by semi-quantitative polymerase chain-reaction (RT-PCR). RESULTS: LPS induced a dramatic increase of both NO production and iNOS mRNA level. The addition of L-NMMA (0.5 mM) abolished NO production without affecting iNOS mRNA levels. In contrast NAC (1 mM) strongly synergized with LPS to stimulate NO synthesis. LPS treatment did not significantly alter TGF-beta1 expression whereas L-NMMA inhibited its production. TGF-beta2 mRNA level was decreased by LPS and was not changed in the presence of L-NMMA. On the other hand, NAC was capable of counteracting the LPS-induced inhibition of TGF-beta2 expression. TGFbeta3 mRNA level was markedly reduced by LPS alone, or with both L-NMMA and NAC. Finally, the expression of TGF-betaRI was slightly increased in the presence of combined LPS and L-NMMA or NAC whereas that of TGFbeta-RII was reduced in the same conditions. CONCLUSIONS: The modulation of TGF-beta system was found to be differentially controlled by NO and ROS productions. Indeed, the control exerted on TGF-beta expression varied according to the isoform: TGF-beta1 mRNA level depends on NO whereas that of TGF-beta2 is regulated by ROS and TGF-beta3 seems to be unaffected by both of them. The expression of TGF-beta receptors appeared to be modulated by NO and ROS levels. The relevance of the present findings to osteoarthritis (OA) physiopathology and the potential use of antioxidant therapy to treat this disease are discussed. [less ▲]

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See detailSkin tensile properties in patients treated for acromegaly.
Braham, Catherine; Betea, Daniela ULg; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(4), 325-9

BACKGROUND: Somatotropic effects are described in the skin. Indeed, acromegaly is in part clinically recognized by cutaneous coarsening. The actual changes in tensile properties associated with the ... [more ▼]

BACKGROUND: Somatotropic effects are described in the skin. Indeed, acromegaly is in part clinically recognized by cutaneous coarsening. The actual changes in tensile properties associated with the cutaneous manifestations are largely unknown. OBJECTIVES: To study the relationships between the skin tensile properties and the severity of acromegaly as assessed by serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). PATIENTS AND METHOD: Assessments were made in 13 patients with acromegaly treated by somatostatin agonists combined or not with surgery. A total of 39 age- and sex-matched healthy subjects served as controls. Skin tensile properties were measured on the forearm and nape of the neck using a computerized suction device. RESULTS: Significant differences were yielded between the skin tensile properties in patients and normal subjects. The highest IGF-1 values in the patients' medical records were positively correlated with both skin distensibility and biologic elasticity. The most recent IGF-1 serum levels were negatively correlated with the visco-elastic ratio. No correlations were yielded between any of the biomechanical parameters and GH levels, disease duration and treatment dosages, respectively. CONCLUSION: The skin in acromegaly appears to be functionally more redundant and elastic than normal skin. The biomechanical changes appear quite different from those observed in other diseases with collagen deposition such as diabetes mellitus and scleroderma. [less ▲]

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See detailEtalonnage de l’épreuve grapho-perceptive de Bender sur une population d’enfants de six à dix ans
Garcet, Serge ULg; Deltour, Jean-Jacques

in Revue Scientifique de l'AIGS (2002), 1

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See detailRéduire la taille des classes dans l'enseignement fondamental : pour des discriminations vraiment positives...
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 11-12

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See detailRecension: "Le contrat d'entreprise. Chronique de jurisprudence (1990-2000)"
Kohl, Benoît ULg

in Actualités du Droit (2002)

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See detailEntre analyse historiciste et interdisciplinarité : Pet Sounds des Beach Boys
Pirenne, Christophe ULg

in Musurgia (2002), IX(2), 9-22

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See detailBulletin bibliographique de la Société Rencesvals, 2001-2002
Henrard, Nadine ULg

in Bulletin bibliographique de la Société Rencesvals (2002), (33), 1-179

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See detailThe lichen flora of the Boulonnais (France, Pas-de-Calais)
Sparrius, L.B.; Diederich, Paul; Signoret, Jonathan et al

in Belgian Journal of Botany (2002), 135

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See detailLe refinancement des communautés et l’extension de l’autonomie fiscale des régions : aspects juridiques et économiques
Bourgeois, Marc ULg; Van Der Stichele, Géraldine; Verdonck, Magali

in Administration Publique [=AP] : Revue du Droit Public et des Sciences Administratives (2002)

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See detailMaladie de Horton et atteintes arterielles extratemporales: utilite de la tomographie par emission de positons au 18FDG. A propos de trois observations et d'une revue de la litterature
Belhocine, Tarik; Kaye, Olivier; Delanaye, Pierre ULg et al

in Revue de Médecine Interne (2002), 23(7), 584-91

PURPOSE: We report three cases of Horton's disease, in which F18-Fluorine-2-Deoxy-D-Glucose (18FDG) positron emission tomography (PET) demonstrated a clinically unsuspected extra-cranial vessels ... [more ▼]

PURPOSE: We report three cases of Horton's disease, in which F18-Fluorine-2-Deoxy-D-Glucose (18FDG) positron emission tomography (PET) demonstrated a clinically unsuspected extra-cranial vessels hypermetabolism. METHODS: Fully corrected whole-body PET was performed in three patients (two women, one man) for exploring a marked inflammatory syndrome. Scanning was acquired 60 min after i.v. injection of 222 MBq of 18FDG in average. RESULTS: In two patients with histologically proven Horton's disease, PET alone showed increased glucose metabolism involving the carotid and sub-clavian arteries as well as the ascending aorta, aortic arch, thoracic and abdominal aorta, and the iliac and femoral arteries. In the third patient, by detecting cervical, thoracic and abdominal vessel hypermetabolism, PET non-invasively contributed to the diagnosis of giant cell arteritis. All patients had complete clinical and biological response to corticoids. PET controls performed 3- to 6-months post-treatment, confirmed the disappearance of the metabolic stigma. CONCLUSION: 18FDG PET may show an increased glucose metabolism in asymptomatic extracranial vessels locations of Horton's arterities. If these observations are confirmed on controlled trials, PET could be particularly useful for non-invasive diagnosing, staging and monitoring atypical clinical forms of Horton's disease. The metabolic imaging could also contribute to a better understanding of the pathogenesis of GCA. [less ▲]

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See detailChoisir un scénario sylvicole pour les mélèzes
Pauwels, D.; Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Forêt Wallonne (2002), (61), 17-24

Le choix du traitement sylvicole à appliquer à un peuplement forestier est une démarche qui peut s’avérer très complexe si l’on tient compte des délais entre la plantation et la récolte du peuplement ... [more ▼]

Le choix du traitement sylvicole à appliquer à un peuplement forestier est une démarche qui peut s’avérer très complexe si l’on tient compte des délais entre la plantation et la récolte du peuplement final, de l’évolution des filières de transformation, ou encore de la multiplicité des objectifs que peut poursuivre le gestionnaire forestier. [less ▲]

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See detailRole of methalothionein in irradiated human rectal carcinoma.
Bouzourene, H; Chabert, P; Gebhardt, S et al

in Cancer (2002), 95(5), 1003-1008

BACKGROUND. Metallothioneins (MT) are low-molecular weight, metal-binding proteins that play a role in cellular proliferation and differentiation, as well as in cellular defense mechanisms. They act as ... [more ▼]

BACKGROUND. Metallothioneins (MT) are low-molecular weight, metal-binding proteins that play a role in cellular proliferation and differentiation, as well as in cellular defense mechanisms. They act as scavengers of free radicals produced by irradiation. A number of in vitro and in vivo studies have linked overexpression of cellular MT with tumor cell resistance to radiation. This is the first study that investigates whether MT expression is involved in the radioresistance of rectal carcinoma. METHODS. Using a mouse monoclonal antibody, MT expression was analyzed by immunohistochemistry on surgical samples (n 85) from 85 patients with locally advanced rectal carcinoma who were treated preoperatively with a hyperfractionated and accelerated radiotherapy schedule and on tumor biopsies (n 13) obtained before treatment. The potential correlations between MT expression and pathologic variables and survival were examined. RESULTS. MT were expressed strongly in both the cytoplasm and nucleus of tumor cells in 7 biopsy and 42 surgical samples. A comparison of MT expression in biopsy and surgical specimens showed that MT expression did not change after irradiation in most cases. Against all expectations, MT were expressed more frequently in tumors from responders than in those from the nonresponders (P 0.02). There was no correlation between MT expression and tumor stage, histology after radiotherapy, or survival. CONCLUSION. These findings do not support the hypothesis that MT overexpression at the end of radiotherapy is a marker for radiation resistance. Cancer 2002;95: 1003–8. © 2002 American Cancer Society. DOI 10.1002/cncr.10780 [less ▲]

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See detailFast And Reliable Chromatographic Procedure For The Purification Of Virginiamycin M-1 Factor
Nott, Katherine ULg; Paquot, Michel ULg; Heilporn, Sylvie et al

in Chromatographia (2002), 56(5-6),

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See detailLes Parents maltraités
Malchair, Alain ULg

in Neurone (2002), 7(3), 83-86

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See detailA propos d'immersion linguistique dans l'enseignement fondamental : un état de la question
Blondin, Christiane ULg; Straeten, M.

in Point sur la Recherche en Education (Le) (2002), 25

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See detailEditorial. Ecrire...
Hindryckx, Geneviève ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 11-12

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See detailUltrasound shear wave propagation in Caucasian hair.
Franchimont, Claudine ULg; Goffin, Véronique ULg; Uhoda, Emmanuelle ULg et al

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

Background : The aspect of hair depends on the spatial organization of the hair shafts and on their chemical, physical and structural integrity. Some genetic disorders and exogenous influences may affect ... [more ▼]

Background : The aspect of hair depends on the spatial organization of the hair shafts and on their chemical, physical and structural integrity. Some genetic disorders and exogenous influences may affect it. Aims : In vivo objective assessments are welcome in order to compare the consequences of hair damages and to assess the kinetics of the changes occurring in time after damaging or attempting to repair the hair structure. Method : Ultrasound shear wave propagation measured on hair is introduced as an objective non-invasive method with in vitro and in vivo applications. Results : With multiple measurements made on the scalp of 72 Caucasians, hair felting following damage appeared to be associated with an increase in the coefficient of variation of the shear wave velocity measurements. Maximum hydration of hair locks increased the shear wave velocity in vitro and decreased the intraindividual range of data. The relevance of the method and reproducibility of data was influenced by the experimentalist skill. Conclusion : Ultrasound shear wave propagation on hair is influenced by the physical integrity of the hair shafts and on their three-dimensional arrangement. [less ▲]

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See detailThe effect of health related quality of life on reported use of health care resources in patients with osteoarthritis and rheumatoid arthritis: a longitudinal analysis.
Ethgen, Olivier ULg; Kahler, Kristijan H; Kong, Sheldon X et al

in Journal of Rheumatology (2002), 29(6), 1147-55

OBJECTIVE: In today's cost conscious environment, health services researchers are consistently trying to find ways to predict future health care resource utilization (HCRU) and its associated costs. We ... [more ▼]

OBJECTIVE: In today's cost conscious environment, health services researchers are consistently trying to find ways to predict future health care resource utilization (HCRU) and its associated costs. We evaluated the impact of health related quality of life (HRQL) on future HCRU in patients with arthritis. METHODS: A total of 642 patients with rheumatoid arthritis (RA) and 395 patients with osteoarthritis (OA) completed at least 2 and as many as 6 consecutive surveys at 6 mo intervals. Information collected included demographics, HRQL questionnaires [Medical Outcome Study Short Form 36 (SF-36), Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), and the Stanford Health Assessment Questionnaire (HAQ)], and HCRU over the previous 6 months. Longitudinal data analysis was perfomed to assess the effect of HRQL on future HCRU. RESULTS: Statistically significant associations between HCRU and HRQL variables were noted. Higher rates of HCRU were found in those in the worst quarter compared with those in the best quarter of HRQL. With the HAQ, OA and RA patients in the worst quarter reported a 199% (p < 0.05) and 48% (p < 0.05) increase in rheumatologist visits, respectively. With the WOMAC Function, increases were as high as 196% (p < 0.05) in rheumatologist visits for patients with OA. Patients with RA with a high level of HRQL as measured by the SF-36 (physical component score) reported a decrease of 31% (p < 0.01) in general practitioner visits and a decrease of 52% (p < 0.01) in hospitalization (mental component score). CONCLUSION: These findings suggest that HRQL may be used to predict future health care consumption. Such an approach may lead to a more efficient allocation of resources by providing useful information to health care providers and health care decision makers. [less ▲]

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See detailRadiologic features poorly predict clinical outcomes in knee osteoarthritis.
Bruyère, Olivier ULg; Honore, Aline; Rovati, Lucio C et al

in Scandinavian Journal of Rheumatology (2002), 31(1), 13-6

OBJECTIVES: To assess the impact of radiographic severity and progression on pain and disability. METHODS: Measurements of mean joint space width (JSW), narrowest join space (NJS) point and assessment of ... [more ▼]

OBJECTIVES: To assess the impact of radiographic severity and progression on pain and disability. METHODS: Measurements of mean joint space width (JSW), narrowest join space (NJS) point and assessment of symptoms by the WOMAC questionnaire were performed at baseline and after three years in 212 subjects over 50 years with primary knee OA. RESULTS: At baseline, JSW and NJS were not significantly correlated with the scores recorded for the WOMAC global index or its pain, stiffness or function subscales. A statistically significant correlation was observed between the joint space narrowing over three years and the changes observed in the pain subscale of the WOMAC during the same period. The three-year changes in the global WOMAC index in patients within the lowest and the highest quartiles of mean joint space width at baseline showed, in both cases, a statistically (p<0.05) significant favorable difference between patients treated with glucosamine sulphate and those having received placebo. CONCLUSION: Radiographic and clinical progressions of the disease are significantly associated but the clinical relevance of the association is questionable. [less ▲]

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See detailPrediction of selectivity for enantiomeric separations of uncharged compounds by capillary electrophoresis involving dual cyclodextrin systems
Abushoffa, Adel M.; Fillet, Marianne ULg; Hubert, Philippe ULg et al

in Journal of Chromatography. A (2002), 948(1-2), 321-9

The single-isomer polyanionic cyclodextrin (CD) derivative heptakis-6-sulfato-beta-cyclodextrin (HSbetaCD) has been tested as chiral additive for the enantioseparation of non-steroidal anti-inflammatory ... [more ▼]

The single-isomer polyanionic cyclodextrin (CD) derivative heptakis-6-sulfato-beta-cyclodextrin (HSbetaCD) has been tested as chiral additive for the enantioseparation of non-steroidal anti-inflammatory drugs, such as fenoprofen, flurbiprofen, ibuprofen and ketoprofen, in capillary electrophoresis, using a pH 2.5 phosphoric acid-triethanolamine buffer in the reversed polarity mode. In most cases, the enantiomers of these acidic compounds, present in uncharged form at that pH, were only poorly resolved with HSbetaCD alone. However, the use of HSbetaCD in combination with the neutral CD derivative, heptakis-(2,3,6-tri-O-methyl)-beta-cyclodextrin (TMbetaCD), which has a particularly high enantioselectivity towards these compounds, has led to complete enantioresolution in reasonably low migration times in most cases. Affinity constants for the enantiomers with the two cyclodextrins were determined, using linear regression in a two-step approach. Affinity constants with the charged HSbetaCD were first calculated in single systems while those with the neutral TMbetaCD were determined in dual systems. Selectivity for the enantiomeric separation of these compounds in dual CD systems could be predicted using recently developed mathematical models. [less ▲]

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See detailImproving the performance of low-gain designs for bounded control of linear systems
Grognard, F.; Sepulchre, Rodolphe ULg; Bastin, G.

in Automatica (2002), 38(11), 1777-1782

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See detailEtude de la perturbation de l'image du corps dans un échantillon de patientes boulimiques
Bragard, Isabelle ULg; Etienne, Anne-Marie ULg; Mayers, I. et al

in Revue Francophone de Clinique Comportementale et Cognitive (2002), 7(2), 5-18

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See detailMultiple pulmonary arteriovenous malformations.
Quaden, C.; Ghaye, Benoit ULg; Dondelinger, Robert ULg et al

in Lancet (2002), 359(9322),

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See detailRegulation by reactive oxygen species of interleukin-1beta, nitric oxide and prostaglandin E(2) production by human chondrocytes.
Mathy, Marianne ULg; Deby, Ginette ULg; Reginster, Jean-Yves ULg et al

in Osteoarthritis and Cartilage (2002), 10(7), 547-55

OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2 ... [more ▼]

OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production by human chondrocytes. The effect of aceclofenac (ACECLO), a non-steroidal antiinflammatory drug (NSAID), was also examined. METHODS: Human chondrocytes were enzymatically isolated from osteoarthritic knee cartilage and then maintained in culture in suspension for 48h in the absence or in the presence of lipopolysaccharide (LPS) (10 microg/ml), L-NMMA (0.5mM), NAC (1mM) or ACECLO (6.10(-6)M). IL-1beta and PGE(2) productions were quantified by specific immunoassays. Nitrite was measured in the culture supernatants by a spectrophotometric method based upon the Griess reaction. Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction. COX-2 protein expression was analysed by Western blot. RESULTS: LPS markedly increased the expression of IL-1beta, iNOS and COX-2 genes. In parallel, NO(2) and PGE(2) amounts found in the culture supernatants were significantly enhanced whereas IL-1beta was immunologically undetectable. The addition of L-NMMA (0.5mM) fully blocked LPS-induced NO production but greatly increased PGE(2) production, suggesting a negative effect of NO on PGE(2) synthesis. Inversely, NO production was stimulated by NAC while PGE(2) production was not affected. Interestingly, NAC increased the IL-1beta and iNOS mRNA levels but did not significantly modify COX-2 mRNA expression. L-NMMA did not significantly affect the expression of IL-1beta, iNOS and COX-2. The amount of COX-2 protein did not change in the presence of the antioxidants. Finally, ACECLO fully blocked the production of PGE(2) by chondrocytes without affecting the levels of COX-2 mRNA. CONCLUSIONS: The stimulation of IL-1beta, NO and PGE(2) production by LPS is differentially controlled by reactive oxygen species (ROS). In fact, L-NMMA and NAC have different mechanisms of action on the regulation of NO and PGE(2) productions. L-NMMA fully inhibits NO but increases PGE(2) production whereas NAC up-regulates NO but does not modify PGE(2) synthesis. The stimulating effect of L-NMMA on PGE(2) production is not controlled at the transcriptional level. These findings suggest that antioxidant therapy could have different effects according to the oxygen radical species targeted. [less ▲]

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See detailPathologie cutanée non infectieuse du pied chez le sportif.
Bourguignon, Raphaël; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatologie Actualité (2002), 72

En dehors du problème des mycoses cutanées, la peau et les ongles des pieds des sportifs sont le siège de diverses maladies bénignes mais qui peuvent cependant s’avérer invalidantes. Les disciplines de ... [more ▼]

En dehors du problème des mycoses cutanées, la peau et les ongles des pieds des sportifs sont le siège de diverses maladies bénignes mais qui peuvent cependant s’avérer invalidantes. Les disciplines de l’athlétisme et quelques autres sports en sont le plus souvent responsables car les microtraumatismes sont fréquemment impliqués. L’identification précise des désordres cutanés aide à prendre les mesures adéquates pour leur prévention. Les traitements sont essentiellement non-invasifs. [less ▲]

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See detailLes figures féminines dans le théâtre de Jean-Marie Piemme
Delhalle, Nancy ULg

in Alternatives Théâtrales (2002), (75),

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See detaille nouvel article 65, alinéa 2 du code pénal et son application dans le temps
Monville, Pierre ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

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See detailChemical changes and influences of rapeseed antinutritional factors on gestating and lactating ewes 1. Animal performances and plasma hormones and glucose
Mandiki, S. N. M.; Derycke, G.; Bister, J. L. et al

in Animal Feed Science & Technology (2002), 98(1-2), 25-35

An experiment was carried out in order to study the effects of high levels of low-glucosinolates (LG)-rapeseed meal of two varieties (Apex or Synergy) on ewes and lambs performances and circulating ... [more ▼]

An experiment was carried out in order to study the effects of high levels of low-glucosinolates (LG)-rapeseed meal of two varieties (Apex or Synergy) on ewes and lambs performances and circulating hormones (progesterone-P4, estradiol-E2,-prolactin-PRL, cortisol, insulin, tri-iodothyronin-T3, thyroxin-T4) and glucose. On the 100th day of gestation, 90 ewes bearing at least two foetuses were divided into 3 groups. Control, Apex and Synergy groups received concentrates with 0, 40 and 40% of LG-rapeseed meal obtained with either Apex (13.77 mumol of glucosinolates/g DM seed) or Synergy (18.19 mumol) variety. Apart from the distribution of pasture hay ad libitum, the ewes received 500 and 1200 g of concentrates/animal per day during gestation and lactation, respectively. Concentrates were offered till the 47th day of lactation, and thereafter, the ewes were fed only with hay during 3 weeks. The lambs received ad libitum concentrates without rapeseed meal from 10 days of age till slaughtering. They were weaned at 65 days of age and were slaughtered when their fattening state was optimal. The performances of ewes (food intake and liveweight profiles) and of lambs (birth liveweight, mortality at birth, weight gains, slaughtering parameters) were not reduced by 40% of LG-rapeseed meal except a decrease in the liveweight for ewes in the Apex group after lambing. The profiles and levels of plasma metabolic (T3, T4, cortisol, insulin) and reproductive (PRL, P4) hormones were not modified by the rapeseed meal. In contrast, the estradiol concentration was lower (P < 0.05) in the two groups of ewes which received rapeseed meal than in the controls as an index of an eventual disturbance in the reproductive functions. In conclusion, large amounts of LG-rapeseed meal may be used as protein supplement in the diet of ewes at the end of gestation and during lactation without negative effects on animal performances and physiology. (c( 2002 Published by Elsevier Science B.V. [less ▲]

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See detailRapid And Homogenous Detection Of Apple Stem Pitting Virus By Rt-Pcr And A Fluorogenic 3 ' Minor Groove Binder-Dna Probe
Salmon, Marc ULg; Vendrame, Marina; Kummert, Jean et al

in European Journal of Plant Pathology (2002), 108(8), 755-762

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See detailCompte rendu de R. GODDING, Prêtres en Gaule mérovingienne, Bruxelles, 2001
George, Philippe ULg

in Moyen Age (Le) (2002)

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See detailCloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.
Colige, Alain ULg; Vandenberghe, Isabel; Thiry, Marc ULg et al

in Journal of Biological Chemistry (2002), 277(8), 5756-66

The processing of amino- and carboxyl-propeptides of fibrillar collagens is required to generate collagen monomers that correctly assemble into fibrils. Mutations in the ADAMTS2 gene, the ... [more ▼]

The processing of amino- and carboxyl-propeptides of fibrillar collagens is required to generate collagen monomers that correctly assemble into fibrils. Mutations in the ADAMTS2 gene, the aminopropeptidase of procollagen I and II, result in the accumulation of non-fully processed type I procollagen, causing human Ehlers-Danlos syndrome type VIIC and animal dermatosparaxis. In this study, we show that the aminopropeptide of type I procollagen can be cleaved in vivo in absence of ADAMTS-2 activity and that this processing is performed at the cleavage site for ADAMTS-2. In an attempt to identify the enzyme responsible for this alternative aminoprocollagen peptidase activity, we have cloned the cDNA and determined the primary structure of human and mouse ADAMTS-14, a novel ADAMTS displaying striking homologies with ADAMTS-2 and -3. The structure of the human gene, which maps to 10q21.3, and the mechanisms of generation of the various transcripts are described. The existence of two sites of initiation of transcription, in two different promoter contexts, suggests that transcripts resulting from these two sites can be differently regulated. The tissue distribution of ADAMTS-14, the regulation of the gene expression by various cytokines and the activity of the recombinant enzyme are evaluated. The potential function of ADAMTS-14 as a physiological aminoprocollagen peptidase in vivo is discussed. [less ▲]

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