References of "Scientific journals"
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See detailDescriptiveness and proper name retrieval
Brédart, Serge ULg; Valentine, T.

in Memory (1998), 6(2), 199-206

Cohen (1990) hypothesised that the retrieval of proper names is particularly difficult because proper names convey little information about their bearers' attributes. In the present study, this hypothesis ... [more ▼]

Cohen (1990) hypothesised that the retrieval of proper names is particularly difficult because proper names convey little information about their bearers' attributes. In the present study, this hypothesis was evaluated by using a face naming task. Faces were those of cartoon and comic-strip characters bearing either arbitrary names or descriptive names. Results unequivocally showed that retrieval blocks occurred more often in naming characters bearing arbitrary names than in naming characters bearing descriptive names. Moreover, retrieving arbitrary names that were also common names was as difficult as retrieving arbitrary names that were not common names. These results support Cohen's claim that arbitrariness plays a significant role in the relative vulnerability of proper name retrieval. [less ▲]

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See detailExpression of Psychrophilic Genes in Mesophilic Hosts: Assessment of the Folding State of a Recombinant Alpha-Amylase
Feller, Georges ULg; Le Bussy, O.; Gerday, Charles ULg

in Applied and Environmental Microbiology (1998), 64(3), 1163-5

Alpha-Amylase from the antarctic psychrophile Altermonas haloplanktis is synthesized at 0 +/- 2 degrees C by the wild strain. This heat-labile alpha-amylase folds correctly when overexpressed in ... [more ▼]

Alpha-Amylase from the antarctic psychrophile Altermonas haloplanktis is synthesized at 0 +/- 2 degrees C by the wild strain. This heat-labile alpha-amylase folds correctly when overexpressed in Escherichia coli, providing the culture temperature is sufficiently low to avoid irreversible denaturation. In the described expression system, a compromise between enzyme stability and E. coli growth rate is reached at 18 degrees C. [less ▲]

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See detailStudy of Spinal Cord Evoked Injury Potential by Use of Computer Modeling and in Dogs with Naturally Acquired Thoracolumbar Spinal Cord Compression
Poncelet, Luc; Michaux, Charles ULg; Grauwels, Magda ULg

in American Journal of Veterinary Research (1998), 59(3), 300-6

OBJECTIVE: To add objective measurements of the characteristics of evoked injury potentials (EIP) and their relations to clinical severity in dogs with thoracolumbar spinal cord damage. ANIMALS: 25 dogs ... [more ▼]

OBJECTIVE: To add objective measurements of the characteristics of evoked injury potentials (EIP) and their relations to clinical severity in dogs with thoracolumbar spinal cord damage. ANIMALS: 25 dogs with naturally acquired spinal cord compression attributable to disk extrusion or vertebral fracture at the level of the thoracolumbar junction and with various degrees of paresis/paralysis. PROCEDURE: Spinal cord potentials evoked by tibial nerve stimulation were recorded every 5 to 10 mm at the lamina level in the vicinity of the cord compression. This allowed an EIP to be recorded even in the least handicapped dogs. A computer model yielded information about the waveform changes of the EIP in the vicinity of conduction blocks. RESULTS: The EIP waveform changed from biphasic to monophasic a short distance caudad to the location of spinal cord compression. Location of a maximal conduction block was measured in relation to position of the electrodes recording this waveform change. The distance between the assumed conduction block and the actual spinal cord compression was larger in the most affected dogs. The amplitude of the EIP was not related to severity of the clinical picture; however, the proximity of the recording electrode to the spine influenced the amplitude and the waveform of the EIP. CONCLUSION AND CLINICAL RELEVANCE: Change in the EIP waveform from biphasic to monophasic makes it possible to estimate the conduction block location along the spinal cord. A large distance between the assumed conduction block and site of actual cord compression could be an objective argument to confirm severity of a lesion. [less ▲]

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See detailThe Gene Encoding the Low-Affinity Penicillin-Binding Protein 3r in Enterococcus Hirae S185r Is Borne on a Plasmid Carrying Other Antibiotic Resistance Determinants
Raze, Dominique; Dardenne, Olivier ULg; Hallut, Séverine et al

in Antimicrobial Agents and Chemotherapy (1998), 42(3), 534-539

Two plasmid-derived NcoI DNA fragments of 14 and 4.5 kb, respectively, have been isolated from the multidrug-resistant strain Enterococcus hirae S185R and analyzed. The 14-kb fragment contains two ... [more ▼]

Two plasmid-derived NcoI DNA fragments of 14 and 4.5 kb, respectively, have been isolated from the multidrug-resistant strain Enterococcus hirae S185R and analyzed. The 14-kb fragment contains two inverted (L and R) IS1216 insertion modules of the ISS1 family. These modules define a Tn5466 transposon-like structure that contains one copy of the methylase-encoding ermAM conferring erythromycin resistance and one copy of the adenylyl-transferase-encoding aadE conferring streptomycin resistance. Immediately on the left side of IS1216L there occurs a copy of pbp3r encoding the low-affinity penicillin-binding protein (PBP) PBP3r, itself preceded by a psr-like gene (psr3r) that controls the synthesis of PBP3r. ermAM, aadE, and the transposase gene (tnp) of IS1216R have the same polarities, and these are opposite those of psr3r, pbp3r, and the tnp gene of IS1216L. The 4.5-kb fragment is a copy of the 4.5-kb sequence at the 5' end of the 14-kb fragment, although it is not a restriction product of the 14-kb fragment. It contains three genes with the same polarity: psr3r, pbp3r, and tnp in an IS1216 element. Because of the very high degree of identity (99%) with the chromosomal psrfm and pbp5fm genes of Enterococcus faecium D63R, it is proposed that both the psr3r and pbp3r genes were transferred from an E.faecium strain and inserted in a plasmid of E. hirae. E. hirae is the first known bacterial species in which a low-affinity PBP-encoding gene has been found to be plasmid borne. [less ▲]

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See detailThe Intrathymic Expression of Insulin-Related Genes: Implications for Pathophysiology and Prevention of Type 1 Diabetes
Geenen, Vincent ULg; Lefebvre, P. J.

in Diabetes/Metabolism Reviews (1998), 14(1), 95-103

Recent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment. There is now compelling ... [more ▼]

Recent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment. There is now compelling evidence that the central immunological tolerance of the whole insulin family may be induced during the process of T-cell ontogeny in the thymus. Transcripts of insulin-like growth factor II (IGF-II), IGF-I and insulin genes have been characterized in human, rat and mouse thymuses. At the peptide level, IGF-II was shown to be the dominant polypeptide of the insulin family in the thymus from different species. Data are presented which support a dual role of thymic IGF-II both in T-cell development as well as in T-cell negative selection. Using animal models of autoimmune diabetes, current research is investigating the hypothesis that a defect of thymic T-cell education to the insulin family is implicated in the pathophysiology of human Type 1 diabetes. An efficient and secure prevention of Type 1 diabetes could be designed on the basis of the strong natural tolerogenic properties of the thymus. [less ▲]

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See detailAnneaux, cibles ou cocardes
Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1998), 53(3), 117-118

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See detailDynamic mechanical thermal and infrared analyses of polyacrylonitrile "electrografted" onto a metal
Calberg, Cédric ULg; Mertens, Marc; Baute, Noëlle et al

in Journal of Polymer Science. Part B, Polymer Physics (1998), 36(4), 543-553

Polyacrylonitrile (PAN) films have been grafted onto copper electrodes by cathodic polarization and analyzed by infrared spectroscopy and dynamic mechanical thermal analysis (DMTA). The dynamic mechanical ... [more ▼]

Polyacrylonitrile (PAN) films have been grafted onto copper electrodes by cathodic polarization and analyzed by infrared spectroscopy and dynamic mechanical thermal analysis (DMTA). The dynamic mechanical response shows two or three transitions depending on the film thickness and the potential deposition. The viscoelastic properties of ungrafted PAN films, e.g., solvent cast films of commercially available PAN, are deeply different from those of electrografted films. The experimental data support that ungrafted chains are paracrystalline in contrast to the grafted ones which are essentially amorphous. Moreover, the irreversible transformation of the grafted PAN chains observed beyond 225°C is confirmed by Fourier transform infrared (FTIR) analysis and ascribed to an intramolecular cyclization of PAN into polyimine. This reaction occurs rapidly and at a comparatively low temperature with respect to ungrafted PAN, which suggests that the grafted chain configuration might be predominantly isotactic. The isotacticity and the amorphous structure appear to decrease as the thickness of the PAN film is increased. Literature data and the herein reported observations would suggest a dependence of the amorphous structure of PAN on the chain isotacticity. [less ▲]

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See detailMalignancy transplantation with heart graft
Detry, Olivier ULg; Hans, Marie-France ULg; Defraigne, Jean-Olivier ULg et al

in Journal of Heart & Lung Transplantation (1998), 17(3), 331-332

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See detailSur l'évaluation des défauts de forme à partir de mesures tridimensionnelles
Debongnie, Jean-François ULg; Masset, Luc ULg

in European Journal of Mechanical and Environmental Engineering (1998), 43(1), 13-21

Owing to the fact that a correct evaluation of form errors is particularly difficult by the classical ways, it seems more efficient to develop numerical algorithms from 3D measures. Several methods are ... [more ▼]

Owing to the fact that a correct evaluation of form errors is particularly difficult by the classical ways, it seems more efficient to develop numerical algorithms from 3D measures. Several methods are described, including direct and iterative ones. A new method is proposed, which is based on Lp-norms and a specialized algorithm. It proved to be the most effective and robust one in every studied application. Another problem which is seldom studied, concerns the sensibility of form errors to measure errors. A theory is presented which leads to a very simple result. [less ▲]

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See detailMoyens de contestation et expropriation
Delnoy, Michel ULg

in Immobilier (1998), 3

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See detailAnatomical Relationships between Aromatase and Tyrosine Hydroxylase in the Quail Brain: Double-Label Immunocytochemical Studies
Balthazart, Jacques ULg; Foidart, Agnès ULg; Baillien, M. et al

in Journal of Comparative Neurology (The) (1998), 391(2), 214-26

The activation of male sexual behavior in Japanese quail (Coturnix japonica) requires the transformation of testosterone to 17beta-estradiol by the enzyme aromatase (estrogen synthetase). There are ... [more ▼]

The activation of male sexual behavior in Japanese quail (Coturnix japonica) requires the transformation of testosterone to 17beta-estradiol by the enzyme aromatase (estrogen synthetase). There are prominent sex differences in aromatase activity that may be regulated in part by sex differences in catecholaminergic activity. In this study, we investigate, with double-label immunocytochemistry methods, the anatomical relationship between the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH) and aromatase (ARO) in the quail brain. The immunoreactivity observed for each antigen generally matched the previously described distribution. One exception is the observation that cells weakly labeled for aromatase were found widely distributed throughout the telencephalon. The presence of telencephalic aromatase was confirmed independently by radioenzymatic assays. There was an extensive overlap between the distribution of the two antigens in many brain areas. In all densely labeled aromatase-immunoreactive (ARO-ir) cell groups, including the preoptic medial nucleus, nucleus of the stria terminalis, mediobasal hypothalamus, and paleostriatum ventrale, ARO-ir cells were found in close association with TH-ir fibers. These TH-ir fibers often converged on an ARO-ir cell, and one or more TH-ir punctate structure(s) were found in close contact with nearly every densely labeled ARO-ir cell. In the telencephalon (mostly the neostriatum), all TH-ir fibers were found to be part of fiber groups that surrounded weakly immunoreactive aromatase cells. The few cells exhibiting an intracellular colocalization were detected in the anteroventral periventricular nucleus. These results are consistent with the hypothesis that catecholaminergic inputs regulate brain aromatase. [less ▲]

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See detailDynamics of poly((dimethylamino)alkyl methacrylate-block-sodium metha-crylate) micelles. Influence of hydrophobicity and molecular architecture on the exchange rate of copolymer molecules
Creutz, Serge; Van Stam, Jan; De Schrijver, Frans C et al

in Macromolecules (1998), 31(3), 681-689

The dynamic stability of the micellar aggregates formed by amphiphilic block copolymers, i.e., poly((dimethylamino)alkyl methacrylate-b-sodium methacrylate), has been investigated by steady-state ... [more ▼]

The dynamic stability of the micellar aggregates formed by amphiphilic block copolymers, i.e., poly((dimethylamino)alkyl methacrylate-b-sodium methacrylate), has been investigated by steady-state fluorescence spectroscopy and size exclusion chromatography. The dynamics of exchange of block copolymer molecules between the micelles, formed in aqueous solution, depend on a manifold of factors, e.g., alkyl substituent in the hydrophobic block, the relation between the hydrophobic and hydrophilic blocks, and the architecture of the block copolymer. All copolymers investigated show a slow unimer exchange with an exchange rate constant on the order of 10-3 s-1, with a difference of a factor of 20 between the fastest and the slowest exchange. It is possible to tune the exchange rate in a controlled way; for instance, an extension or branching of the alkyl chain slows down the exchange rate. The same effect is observed when the hydrophobic/hydrophilic balance of these copolymers is increased or when either the hydrophilic or the hydrophobic moiety of diblocks is divided into two external blocks, leading to a triblock copolymer. [less ▲]

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See detailPoly(2-oxepane-1,5-dione) : a highly crystalline modified poly (epsilon-caprolactone) of a high melting temperature
Tian, Dong; Halleux, Olivier; Dubois, Philippe ULg et al

in Macromolecules (1998), 31(3), 924-927

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See detailCloning of the Rat Brain Cdna Encoding for the Slc-1 G Protein-Coupled Receptor Reveals the Presence of an Intron in the Gene
Lakaye, Bernard ULg; Minet, Arlette ULg; Zorzi, Willy ULg et al

in Biochimica et Biophysica Acta (1998), 1401(2), 216-20

In order to isolate new G protein-coupled receptors expressed in the cerebral cortex, a set of degenerate oligonucleotides corresponding to the third and seventh transmembrane segment were synthetized ... [more ▼]

In order to isolate new G protein-coupled receptors expressed in the cerebral cortex, a set of degenerate oligonucleotides corresponding to the third and seventh transmembrane segment were synthetized. Their use in PCR on rat brain cortex mRNA amplified several cDNA fragments. One of them, a 526 bp sequence, encoded for what was at that time an unknown G protein-coupled receptor. An oligonucleotide derived from the sequence was then used as a probe to isolate the receptor cDNA from a rat brain cDNA library. It encodes for a 353aa protein with seven transmembrane segments, three consensus N-glycosylation sites at the amino terminus and several potential phosphorylation sites in the intracellular loops. This protein shares 91% overall identity with a recently cloned human somatostatin-like receptor of 402aa named SLC-1. This suggests that we have cloned the rat orthologue of the human SLC-1. However, the extracellular N-terminus of the human receptor is 49 amino acids longer and shows 50% identity with the rat one. Because the human sequence was deduced from genomic DNA, we suspected the presence of an intron in the gene. This was confirmed by PCR using primers spanning the intron. On the basis of the sequence of a 128 kb fragment of chromosome 22 encompassing the SLC-1 gene, we were able to deduce a corrected amino acids sequence for the human receptor. So both rat and human SLC-1 receptors are 353aa long, with three consensus N-glycosylation sites. They share 96% identity at the amino acid level and are encoded by a gene containing one intron in the coding sequence. [less ▲]

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See detailExternal Quality Assessment (Eqa) of Belgian Clinical Laboratories. The Telematics Paradigm
Albert, Adelin ULg; De Moor, G.; Libeer, J. C.

in Clinica Chimica Acta (1998), 270(1), 43-54

Technology that enables communication between information systems has recently become cheaper and more powerful. It is therefore timely to consider the effects of the introduction of such techniques in ... [more ▼]

Technology that enables communication between information systems has recently become cheaper and more powerful. It is therefore timely to consider the effects of the introduction of such techniques in external quality assessment (EQA) schemes on both users and organizers. Traditionally, results are returned to EQA organizers as hand-written numbers on structured forms. These data are then manually entered into a computer. The process is time-consuming, slow (as it depends on the postal service), prone to error at every transcription stage, and expensive, as clerical staff must be employed to input the data. Computer-to-computer communication allows this process to be improved. A telematics system for electronic data interchange has been developed for the Belgian EQA programme and it offers several advantages, such as the use of standardized semantics, expression of results in laboratory familiar units, possible interface with the Laboratory Information System, faster data analysis, shorter report time and long-term performance evaluation. [less ▲]

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See detailDetection of the lensing galaxy in HE 1104-1805
Courbin, F.; Lidman, C.; Magain, Pierre ULg

in Astronomy and Astrophysics (1998), 330

We report on deep IR imaging of the double quasar HE 1104-1805. A new image deconvolution technique has been applied to the data in order to optimally combine the numerous frames obtained. The resulting J ... [more ▼]

We report on deep IR imaging of the double quasar HE 1104-1805. A new image deconvolution technique has been applied to the data in order to optimally combine the numerous frames obtained. The resulting J and K' images allow us to detect and study the lensing galaxy between the two lensed QSO images. The near infrared images not only confirm the lensed nature of this double quasar, but also support the previous redshift estimate of z=1.66 for the lensing galaxy. No obvious overdensity of galaxies is detected in the immediate region surrounding the lens, down to limiting magnitudes of J=22 and K=20. The geometry of the system, together with the time delays expected for this lensed quasar, make HE 1104-1805 a remarkable target for future photometric monitoring programs, for the study of microlensing and for the determination of the cosmological parameters in the IR and optical domains. Based on observations obtained at ESO, La Silla, Chile [less ▲]

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See detailThe observed periods of Ap and Bp stars
Catalano, F. A.; Renson, Pierre ULg

in Astronomy and Astrophysics. Supplement Series (1998), 127

A catalogue of all the periods up to now proposed for the variations of CP2, CP3, and CP4 stars is presented. The main identifiers (HD and HR), the proper name, the variable-star name, and the spectral ... [more ▼]

A catalogue of all the periods up to now proposed for the variations of CP2, CP3, and CP4 stars is presented. The main identifiers (HD and HR), the proper name, the variable-star name, and the spectral type and peculiarity are given for each star as far as the coordinates at 2000.0 and the visual magnitude. The nature of the observed variations (light, spectrum, magnetic field, etc.) is presented in a codified way. The catalogue is arranged in three tables: the bulk of the data, i.e. those referring to CP2, CP3, and CP4 stars, are given in Table 1, while the data concerning He-strong stars are given in Table 2 and those for eclipsing or ellipsoidal variables are collected in Table 3. Notes are also provided at the end of each table, mainly about duplicities. The catalogue contains data on 364 CP stars and is updated to 1996, October 31. This research has made use of the SIMBAD database, operated at CDS, Strasbourg, France. [less ▲]

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See detailEffects of Macrophage Transplantation in the Injured Adult Rat Spinal Cord: A Combined Immunocytochemical and Biochemical Study
Franzen, Rachelle ULg; Schoenen, Jean ULg; Leprince, Pierre ULg et al

in Journal of Neuroscience Research (1998), 51(3), 316-27

Early and robust invasion by macrophages may be one of the reasons why axonal regeneration is more effective in the PNS than in the CNS. Therefore, we have grafted autologous peritoneal macrophages ... [more ▼]

Early and robust invasion by macrophages may be one of the reasons why axonal regeneration is more effective in the PNS than in the CNS. Therefore, we have grafted autologous peritoneal macrophages labeled with fluorescent latex microspheres into spinal cord compression lesions. At various survival times, we have studied their effect on the expression of neuronal (neurofilaments [NF], calcitonin gene-related peptide [CGRP], 5-hydroxytryptamine [5-HT]) and nonneuronal markers (myelin-associated glycoprotein [MAG], glial fibrillary acidic protein [GFAP], laminin) by using semiquantitative Western blot and immunohistochemical techniques. After 1 month, we observed a significant decrease of the expression of MAG as well as an important invasion of the lesion site by neurites, chiefly peptidergic axons of presumed dorsal root origin, in macrophage-grafted animals compared with controls. In addition, angiogenesis and Schwann cell infiltration were more pronounced after macrophage grafts, providing an increase in laminin, a favorable substrate for axonal regrowth. By using reverse transcription-polymerase chain reaction (RT-PCR), mRNAs for tumor necrosis factor-alpha (TNF-alpha) were detected in the transplanted cells, whereas results were negative for nerve growth factor (NGF), neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), or acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF). Thus, macrophage grafts may represent an interesting strategy to promote axonal regeneration in the CNS. Our study suggests that they may exert their beneficial effects by degrading myelin products, which inhibit axonal regrowth, and by promoting a permissive extracellular matrix containing notably laminin. No evidence for a direct synthesis of neurotrophic factors by the transplanted macrophages was found in this study, but resident glial cells could secrete such factors as a result of stimulation by macrophage-released cytokines. [less ▲]

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See detailField halo stars: the globular cluster connection
Jehin, Emmanuel ULg; Magain, Pierre ULg; Neuforge, Corinne et al

in Astronomy and Astrophysics (1998), 330

High resolution and high signal-to-noise spectra of about 20 metal-poor stars have been analysed. The correlations between the relative abundances of 16 elements have been studied, with a special emphasis ... [more ▼]

High resolution and high signal-to-noise spectra of about 20 metal-poor stars have been analysed. The correlations between the relative abundances of 16 elements have been studied, with a special emphasis on the neutron-capture ones. This analysis reveals the existence of two subpopulations of field halo stars, namely Pop IIa and Pop IIb. They differ by the behaviour of the s-process elements versus the alpha and r-process elements. A scenario for the formation of these stars is presented, which closely relates the origin of field halo stars to the evolution of globular clusters. According to this scenario, the two sub-populations originate from two different stages in the globular cluster's chemical evolution. Based on observations carried out at the European Southern Observatory (La Silla, Chile) [less ▲]

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See detailDeconvolution with Correct Sampling
Magain, Pierre ULg; Courbin, F.; Sohy, Sandrine ULg

in Astrophysical Journal (1998), 494

A new method for improving the resolution of astronomical images is presented. It is based on the principle that sampled data cannot be fully deconvolved without violating the sampling theorem. Thus, the ... [more ▼]

A new method for improving the resolution of astronomical images is presented. It is based on the principle that sampled data cannot be fully deconvolved without violating the sampling theorem. Thus, the sampled image should be deconvolved not by the total point-spread function but by a narrower function chosen so that the resolution of the deconvolved image is compatible with the adopted sampling. Our deconvolution method gives results that are, in at least some cases, superior to those of other commonly used techniques: in particular, it does not produce ringing around point sources superposed on a smooth background. Moreover, it allows researchers to perform accurate astrometry and photometry of crowded fields. These improvements are a consequence of both the correct treatment of sampling and the recognition that the most probable astronomical image is not a flat one. The method is also well adapted to the optimal combination of different images of the same object, as can be obtained, e.g., from infrared observations or via adaptive optics techniques. [less ▲]

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See detailTyping of Nosocomial Strains of Serratia Marcescens: Comparison of Pulsed-Field Gel Electrophoresis of Macrorestriction Fragments with Biotyping, Esterase Typing and Ribotyping
Chetoui, Hafid; Delhalle, Edmond; Melin, Pierrette ULg et al

in Research in Microbiology (1998), 149(2), 137-43

Fifty nosocomial isolates of Serratia marcescens, collected in six Belgian hospitals between 1986 and 1990, were characterized by using pulsed-field gel electrophoresis (PFGE) with XbaI. The results were ... [more ▼]

Fifty nosocomial isolates of Serratia marcescens, collected in six Belgian hospitals between 1986 and 1990, were characterized by using pulsed-field gel electrophoresis (PFGE) with XbaI. The results were compared with those previously obtained by three other methods: biotyping, esterase electrophoresis typing and ribotyping with EcoRI and HindIII. Macrorestriction analysis (42 PFGE groups) and esterase typing (42 zymotypes) proved to be the most discriminating, followed by ribotyping (28 ribotypes) and biotyping (10 biochemical profiles). Biotyping would serve as a screen to identify isolates, due to its accessibility. Esterase typing provided a reliable tool to make subdivisions within biotypes because of congruence between biochemical groups and esterase patterns. Additional discrimination was still achieved by ribotyping and PFGE. It is concluded that the combined results of these four markers were useful for distinguishing all epidemic and sporadic isolates. [less ▲]

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See detailEtat actuel des transplantations d'organes: place à la xénotransplantation?
Franssen, Colette ULg; Lambrigts, D.; Degesves, S. et al

in Revue Médicale de Liège (1998), 53(2), 97-102

In the last few years, transplantation was an area of intense research activity. However, there is a worldwide shortage of donor organs for clinical transplantations. Currently, interest in ... [more ▼]

In the last few years, transplantation was an area of intense research activity. However, there is a worldwide shortage of donor organs for clinical transplantations. Currently, interest in xenotransplantation research is growing not only because of the increased demand for organs but also because of advances in molecular biology techniques that make possible the genetic or immunological manipulations of the animal donor rather than the human recipient. The better definitions of the mechanisms responsible for xenograft rejection should facilitate appropriate therapeutic strategies for long xenograft survival. [less ▲]

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See detailMalignant Melanoma Staging Using Whole-Body Positron Emission Tomography
Paquet, Philippe ULg; Hustinx, Roland ULg; Rigo, Pierre ULg et al

in Melanoma Research (1998), 8(1), 59-62

The correct staging of potentially metastatic melanoma is essential for an appropriate therapeutic attitude. Current methods include computed tomography, magnetic resonance imaging, ultrasonography and ... [more ▼]

The correct staging of potentially metastatic melanoma is essential for an appropriate therapeutic attitude. Current methods include computed tomography, magnetic resonance imaging, ultrasonography and scintigraphy. Another tool is whole-body positron tomography using the radiopharmaceutical 2-fluorine-18-fluoro-2-deoxy-D-glucose as an emitter because it accumulates inside neoplasms, especially melanoma. We report two cases of malignant melanoma in which computed tomography and magnetic resonance imaging suggested visceral metastatic spread. In contrast, whole-body positron emission tomography indicated the absence of metastases, and this was confirmed by histological examination of the organs where metastases were suspected. Whole-body positron emission tomography appears to have high specificity and sensitivity for clinical melanoma staging. [less ▲]

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See detailEffectiveness of High-Dose Riboflavin in Migraine Prophylaxis. A Randomized Controlled Trial
Schoenen, Jean ULg; Jacquy, J.; Lenaerts, M.

in Neurology (1998), 50(2), 466-70

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared ... [more ▼]

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared riboflavin (400 mg) and placebo in 55 patients with migraine in a randomized trial of 3 months duration. Using an intention-to-treat analysis, riboflavin was superior to placebo in reducing attack frequency (p = 0.005) and headache days (p = 0.012). Regarding the latter, the proportion of patients who improved by at least 50%, i.e. "responders," was 15% for placebo and 59% for riboflavin (p = 0.002) and the number-needed-to-treat for effectiveness was 2.3. Three minor adverse events occurred, two in the riboflavin group (diarrhea and polyuria) and one in the placebo group (abdominal cramps). None was serious. Because of its high efficacy, excellent tolerability, and low cost, riboflavin is an interesting option for migraine prophylaxis and a candidate for a comparative trial with an established prophylactic drug. [less ▲]

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See detailBiodegradable and biocompatible inorganic-organic hybrid materials. 2. Dynamic mechanical properties, structure and morphology
Tian, Dong; Blacher, Silvia ULg; Dubois, Philippe ULg et al

in Polymer (1998), 39(4), 855-864

Dynamic mechanical properties, structure and morphology of tetraethoxysilane/poly(ε-caprolactone) (TEOS/ PCL) hybrid materials have been analysed by dynamic mechanical spectroscopy, small-angle X-ray ... [more ▼]

Dynamic mechanical properties, structure and morphology of tetraethoxysilane/poly(ε-caprolactone) (TEOS/ PCL) hybrid materials have been analysed by dynamic mechanical spectroscopy, small-angle X-ray scattering, transmission electron microscopy, and image analysis. The experimental observations agree with a microscopic phase separation of the two constitutive components: the organic polymer and the silica network. The effect of the PCL functional end-groups, the number of functional end-groups per PCL chain, the PCL molecular weight and content, and the curing conditions have been studied on the structure and properties of the hybrid materials. Finally, phase morphology has proved to be co-continuous, at least when the weight composition is close to 50% for each component (SiO2 and PCL), with a characteristic length between the PCL and silica phases of ca. 5 nm, as estimated by image analysis of transmission electron micrographs. [less ▲]

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See detailLe cas clinique du mois. A propos d'un cas de ganglioneurome surrénalien: les incidentalomes
QUATRESOOZ, Pascale ULg; THIRY, Albert ULg; BONIVER, Jacques ULg

in Revue Médicale de Liège (1998), 53(2), 63-6

We present a case of adrenal ganglioneuroma discovered during a gastric exploration. We review and discuss the recent literature about "incidentaloma". We propose a reflexion about the investigation of ... [more ▼]

We present a case of adrenal ganglioneuroma discovered during a gastric exploration. We review and discuss the recent literature about "incidentaloma". We propose a reflexion about the investigation of these masses. [less ▲]

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See detailEvidence That Breast Cancer Associated Microcalcifications Are Mineralized Malignant Cells
Castronovo, Vincenzo ULg; Bellahcene, Akeila ULg

in International Journal of Oncology (1998), 12(2), 305-8

Microcalcifications are often associated with both benign and malignant human breast lesions. Around 40% of mammary carcinoma present such ectopic mineralization and frequently, they are the only ... [more ▼]

Microcalcifications are often associated with both benign and malignant human breast lesions. Around 40% of mammary carcinoma present such ectopic mineralization and frequently, they are the only mammographic feature that indicate the presence of a tumoral lesion. Microcalcifications associated with breast cancer are usually composed of hydroxyapatite, the bone specific mineral. The mechanisms responsible for the formation of such crystals within breast malignant tissue have not been elucidated. A possible clue could be provided by the recent demonstration that breast cancer cells express several bone matrix proteins including osteonectin, osteopontin and bone sialoprotein (BSP). This latter phospho-protein is involved in the initiation of hydroxyapatite crystallisation and its expression in breast cancer has been associated to the presence of hydroxyapatite microcalcifications. We examined 10 human breast cancer lesions which were characterized by the presence of microcalcifications and high expression of BSP. Histological examination of the lesions suggested, in most of the cases, that the microcalcifications were breast cancer cells which became mineralized. Hydroxyapatite stained in blue by hematoxylin appears concentrated around single of associated cancer cells. Staining of these tissue sections with 4',6 diamidino-2-phenylindole which specifically labels DNA led us to demonstrate that the mineralizated structures contain cells. These data are the first direct demonstration that breast microcalcifications are fossils of cancer cells. The mechanisms for such a phenomenon remain to be demonstrated. We speculate that the high expression of BSP could create an appropriate microenvironment for the crystallisation of calcium and phosphate into hydroxyapatite. [less ▲]

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See detailBronchial Responsiveness in Active Steelworkers
Corhay, Jean-Louis ULg; Bury, Thierry ULg; Louis, Renaud ULg et al

in European Respiratory Journal (1998), 11(2), 272-7

Coke-oven workers are exposed to dust and irritant gases. Therefore they are at risk of developing lung diseases including chronic bronchitis. Nonspecific bronchial hyperresponsiveness (BHR) has been ... [more ▼]

Coke-oven workers are exposed to dust and irritant gases. Therefore they are at risk of developing lung diseases including chronic bronchitis. Nonspecific bronchial hyperresponsiveness (BHR) has been advocated as a potential risk factor predisposing to the development of chronic bronchitis. In a previous study, we showed that prevalence of BHR was higher in retired coke-oven workers than in retired blast furnace workers. The present study was carried out to determine the prevalence of BHR in active steelworkers. Thus, 137 coke-oven workers and 150 blast furnace workers underwent clinical examination, a standardized questionnaire for the study of respiratory symptoms, pulmonary function testing and methacholine aerosol challenge. The study demonstrates a higher prevalence and degree of BHR [provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (PC20) < or = 8 mg x mL(-1)] in coke-oven workers than in blast furnace workers (31.4 versus 6.7%; p<0.001). Moreover, the frequency of respiratory symptoms and basal bronchial obstruction were greater among coke-oven workers with BHR in nonresponders. The basal maximum expiratory flow from 25-75% of forced vital capacity and the respiratory symptoms were correlated with bronchial responsiveness. The lack of correlation observed between BHR and the intensity of smoking or years spent in coke-oven environment may be explained by the high proportion of smokers, the worker turnover in the steel plant, and the "healthy worker effect". In conclusion, the higher prevalence and degree of bronchial hyperresponsiveness in coke-oven workers suggests that coke-oven pollutants are more intense irritants than those that escape from blast furnaces. [less ▲]

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See detailThe Nd-123 superconducting system: From single crystal to top-seeded large grain. Physical and chemical parameters influence
Auguste, F.; Vandewalle, Nicolas ULg; Ausloos, Marcel ULg et al

in Applied Superconductivity (1998), 6(2-5), 77-85

Nd-123 signle crystals have been produced via the Aux method in alumina crucibles by controlling the chemical composition of the flux. For so doing, quenched materials have been prepared and analyzed in ... [more ▼]

Nd-123 signle crystals have been produced via the Aux method in alumina crucibles by controlling the chemical composition of the flux. For so doing, quenched materials have been prepared and analyzed in order to get information about the optimum barium: copper ratio for an unchanged neodymium concentration. Non corrosive fluxes with a low viscosity have been put into evidence and can thus be used for single crystal production. Experiments have been performed with three different chemical compositions of the Aux and by considering various amounts of neodymium oxide for each system. The single crystals have been analyzed by energy dispersive X-ray microanalysis and used for the synthesis of large Dy-123 single-domains? [less ▲]

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See detailCouverture des besoins en proteines et acides amines des vaches laitieres hautes productrices.
Thewis, André ULg

in Elevages Belges (1998), 52(2), 34-37

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See detailCabergoline in the treatment of acromegaly: a study in 64 patients.
Abs, Roger; Verhelst, Johan; Maiter, Dominique et al

in Journal of Clinical Endocrinology and Metabolism (1998), 83(2), 374-8

Cabergoline is a new, long acting, dopamine agonist that is more effective and better tolerated than bromocriptine in patients with hyperprolactinemia. Because dopamine agonists still have a place in the ... [more ▼]

Cabergoline is a new, long acting, dopamine agonist that is more effective and better tolerated than bromocriptine in patients with hyperprolactinemia. Because dopamine agonists still have a place in the medical management of acromegaly, cabergoline might be a useful treatment. We, therefore, evaluated the effect of long term administration of cabergoline in a large group of unselected acromegalic patients. Sixty-four patients were included in a multicenter, prospective, open labeled study. A subgroup of 16 patients had GH-/PRL-cosecreting pituitary adenomas. Cabergoline was started at a dose of 1.0 mg/week and was gradually increased until normalization of plasma insulin-like growth factor I (IGF-I) levels, occurrence of unacceptable side-effects, or a maximal weekly dose of 3.5 mg (7.0 mg in 1 case) was reached. Treatment with cabergoline suppressed plasma IGF-I below 300 micrograms/L in 39% of cases and between 300-450 micrograms/L in another 28%. With pretreatment plasma IGF-I concentrations less than 750 micrograms/L, a suppression of IGF-I below 300 micrograms/L was obtained in 53% of cases, and a suppression between 300-450 micrograms/L was obtained in another 32%. By contrast, with pretreatment plasma IGF-I concentrations above 750 micrograms/L, only 17% of cases showed a suppression of IGF-I below 300 micrograms/L, and there was IGF-I suppression between 300-450 micrograms/L in another 21%. In GH-/PRL-cosecreting adenomas, 50% of cases suppressed plasma IGF-I levels below 300 micrograms/L, and another 31% did so between 300-450 micrograms/L, in contrast to only 35% and 27%, respectively in GH-secreting adenomas. Similar results were obtained concerning the secretion of GH. Tumor shrinkage was demonstrated in 13 of 21 patients, with a mass reduction by more than half in 5 GH-/PRL-cosecreting adenomas. Except for slight gastrointestinal discomfort and orthostatic hypotension in a few patients at the beginning of therapy, cabergoline treatment was well tolerated. Only 2 patients stopped medication because of nausea. The weekly dose of cabergoline ranged between 1.0-1.75 mg. A further increase in the dose was only effective in 1 GH-/PRL-cosecreting adenoma. The results of this study suggest that cabergoline is an effective, well tolerated therapy that should be considered in the management of acromegaly, especially if the pituitary adenoma cosecretes GH and PRL or if pretreatment plasma IGF-I levels are below 750 micrograms/L. [less ▲]

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See detailGrowth of pulmonary artery after arterial switch operation for simple transposition of the great arteries.
Massin, M. M.; Nitsch, G. B.; Dabritz, S. et al

in European Journal of Pediatrics (1998), 157(2), 95-100

This retrospective study attempts to assess the size and growth pattern of the pulmonary artery about 1 year after neonatal arterial switch operation for simple transposition of the great arteries. Sixty ... [more ▼]

This retrospective study attempts to assess the size and growth pattern of the pulmonary artery about 1 year after neonatal arterial switch operation for simple transposition of the great arteries. Sixty-seven patients underwent cardiac catheterization, including catheterization of the right and left pulmonary arteries, and right ventricular angiography an average of 13.9 months after arterial switch operation. In 34 of these patients pre-operative right ventricular angiocardiograms were available. The diameter of the main pulmonary artery and that of its proximal right and left branches were measured. The values were compared to those of normal children matched for body surface area, taken from the literature and, for the branch values, related to the degree of branch stenosis and to the corresponding values, measured on pre-operative angiocardiograms. The cross-section of the main pulmonary artery after arterial switch operation with Lecompte manoeuvre becomes oval. The branches of the pulmonary artery are sometimes underdeveloped and this finding is related to branch stenosis. The ratio of the branch gradients is inversely proportional to the growth ratio of both branches while the pre- and postoperative Nakata indices are identical. CONCLUSION: The Lecompte manoeuvre induces a flattening of the main pulmonary artery with concomitant reduction of its cross-sectional area. There is also frequently trivial or rarely moderate branch pulmonary stenosis which is accompanied by growth retardation of the concerned branch. [less ▲]

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See detailSystemic and Intracerebroventricular Injections of Vasotocin Inhibit Appetitive and Consummatory Components of Male Sexual Behavior in Japanese Quail
Castagna, C.; Absil, Philippe ULg; Foidart, Agnès ULg et al

in Behavioral Neuroscience (1998), 112(1), 233-50

The authors investigated the behavioral actions of vasotocin (VT) in castrated testosterone-treated male Japanese quail. The appetitive and consummatory components of sexual behavior as well as the ... [more ▼]

The authors investigated the behavioral actions of vasotocin (VT) in castrated testosterone-treated male Japanese quail. The appetitive and consummatory components of sexual behavior as well as the occurrence frequency of crows were inhibited, in a dose-dependent manner, by injections of VT. The authors observed opposite effects after injection of the V1 receptor antagonist, dPTyr(Me)AVP. Lower doses of VT were more active after central than after systemic injection, and effects of systemic injections of VT were blocked by a central injection of dPTyr(Me)AVP. The behavioral inhibition was associated with a modified diuresis after systemic but not central injection. These results provide direct evidence that VT affects male sexual behavior in quail by a direct action on the brain independent of its peripheral action on diuresis. [less ▲]

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See detailComparison between the Natural Postnatal Maturation and the Spermine-Induced Maturation of the Rat Intestine
Peulen, Olivier ULg; Pirlet, Christine; Klimek, Monique ULg et al

in Archives of Physiology & Biochemistry (1998), 106(1), 46-55

In the suckling rats, orally provided spermine induced structural and biochemical changes in the intestine, which are characteristics of the postnatal maturation. This induced maturation was compared to ... [more ▼]

In the suckling rats, orally provided spermine induced structural and biochemical changes in the intestine, which are characteristics of the postnatal maturation. This induced maturation was compared to that occurring spontaneously. Eight mumol spermine were administered orally once a day, for one or three days, to suckling rats which were 11 days old at the beginning of the experiment. The animals were killed 0, 2, 4, 6, 8, 10 hours or 3 days after the first treatment. Control rats from the same litter were treated in the same way but received only the vehicle. In order to complete the study of the naturally occurring maturation, another group of rats was killed when they were 12, 13, 15, 16, 17, 18, 19, 20, 21 or 30 days old. Animal and intestine weights were measured. Disaccharidase specific activity, and protein, DNA and RNA contents were estimated in the small intestine. Histological and ultrastructural aspects of the intestinal mucosa were examined. For all these parameters, the maturation induced by spermine ingestion appeared close to that occurring naturally at weaning. Consequently, dietary spermine induces all the morphological and biochemical modifications characterizing the intestinal postnatal maturation in the suckling rat suggesting a role of the polyamines in the naturally occurring processes. [less ▲]

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See detailDifferentiation Among Potyviruses Infecting Sweet Potato Based on Genus- and Virus-Specific Reverse Transcription Polymerase Chain Reaction
Colinet, Dominique; Nguyen, Minh ULg; Kummert, Jean et al

in Plant Disease (1998), 82(fevrier), 223-229

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See detailDelayed-onset profound biotnidase deficiency
Wolf, B.; Pomponio, R.; Norrgard, K. et al

in Journal of Pediatrics (1998), 132(2), 362-365

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb ... [more ▼]

Children with biotinidase deficiency usually exhibit symptoms at several months to years of age. We describe four children who had symptoms later in childhood or during adolescence; they had motor limb weakness, spastic paresis, and eye problems, such as loss of visual acuity and scotomata, rather than the more characteristic symptoms observed in young untreated children with the disorder. These older children each have different mutations, but they are the same as those of children who have exhibited symptoms at on early age. Biotinidase deficiency should be considered in older children who suddenly experience limb weakness and/or spastic paresis and eye symptoms. [less ▲]

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See detailExpropriations d'extrême urgence
Delnoy, Michel ULg

in Immoblier (1998), 2

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See detailControlled radical polymerization of methyl methacrylate initiated by an alkyl halide in the presence of the Wilkinson catalyst
Moineau, Georges; Granel, Claude; Dubois, Philippe ULg et al

in Macromolecules (1998), 31(2), 542-544

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See detailDual living free radical and ring opening polymerizations from a double-headed initiator
Hawker, Craig J; Hedrick, James L; Malmström, Eva E et al

in Macromolecules (1998), 31(2), 213-219

The concept of performing dual living polymerizations from a single initiating molecule with no intermediate activation, or transformation, steps is presented. The compatibility of “living”, or controlled ... [more ▼]

The concept of performing dual living polymerizations from a single initiating molecule with no intermediate activation, or transformation, steps is presented. The compatibility of “living”, or controlled free radical procedures, either nitroxide mediated or atom transfer radical polymerization (ATRP), with the living ring opening polymerization of ε-caprolactone, and vice versa, is demonstrated by the synthesis of a variety of well-defined block copolymers. For example, from a hydroxy-functionalized alkoxyamine, either the living ring opening polymerization of ε-caprolactone, or the “living” free radical polymerization of styrene can be performed leading to narrow polydispersity polymeric initiators. These polymeric initiators can then be used to initiate the living polymerization of the other monomer system without the need for intermediate steps. In a similar way, hydroxy-functionalized ATRP initiators can be used as bifunctional initiators for the polymerization of both ε-caprolactone and a variety of other vinyl monomers. The novel block copolymers that are obtained were shown to have low polydispersities and controllable molecular weights for both of the blocks. [less ▲]

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See detailComparative Effects of University of Wisconsin and Euro-Collins Solutions on Pulmonary Mitochondrial Function after Ischemia and Reperfusion
Detry, Olivier ULg; Willet, K.; Lambermont, Bernard ULg et al

in Transplantation (1998), 65(2), 161-6

BACKGROUND: The aim of this study was to compare the effects of Euro-Collins and University of Wisconsin solutions on pulmonary mitochondrial function after cold ischemia and subsequent warm reperfusion ... [more ▼]

BACKGROUND: The aim of this study was to compare the effects of Euro-Collins and University of Wisconsin solutions on pulmonary mitochondrial function after cold ischemia and subsequent warm reperfusion. METHODS: Seventeen pigs underwent lung harvesting after classical lung flush with either University of Wisconsin or Euro-Collins solutions. The mitochondria were isolated from fresh swine lungs, from swine lungs subjected to 24 hr of cold ischemia, and from swine lungs subjected to 24 hr of ischemia followed by 30 min of subsequent ex vivo reperfusion at 37 degrees C with Krebs-Henseleit buffer solution and air ventilation. Mitochondrial oxidative phosphorylation parameters were determined in isolated mitochondria by in vitro measurement of oxygen consumption rates. During reperfusion, the lung function was assessed by the pulmonary aerodynamic parameters and the pulmonary vascular resistance. RESULTS: Relative to controls, mitochondria submitted to cold ischemia showed an alteration in the oxidoreductase activities of the respiratory chain. However, the yield of oxidative phosphorylation was conserved. After reperfusion, pulmonary mitochondria underwent a significant worsening in the oxidoreductase activities of the respiratory chain, and a decrease in the respiratory control and the efficiency of oxidative phosphorylation. Meanwhile, the reperfused lungs showed evidence of early dysfunction, assessed by the aerodynamic parameters and pulmonary vascular resistance. In this model, there was no advantage of University of Wisconsin solution over Euro-Collins solution. CONCLUSIONS: The mild mitochondrial alterations after cold ischemia were not sufficient to explain the limited tolerance of lung to ischemia. After reperfusion, the mitochondrial damage was more severe and could be involved in the posttransplant lung dysfunction. [less ▲]

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See detailStrychnochrysine, a New Bisindole Alkaloid from the Roots of Strychnos Nux-Vomica
Biala, Rose Gadi; Tits, Monique ULg; Penelle, Jacques et al

in Journal of Natural Products (1998), 61(1), 139-41

The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was ... [more ▼]

The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was defined by detailed spectroscopic methods. [less ▲]

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See detailSolvent effect on the electrografting of acrylonitrile on nickel
Mertens, Marc; Calberg, Cédric ULg; Baute, Noëlle et al

in Journal of Electroanalytical Chemistry (1998), 441(1-2), 237-244

The effect of solvent on the reductive electrografting of acrylonitrile (AN) onto nickel cathodes has been studied in dimethylformamide (DMF), a solvent for polyacrylonitrile (PAN), and in non-solvents ... [more ▼]

The effect of solvent on the reductive electrografting of acrylonitrile (AN) onto nickel cathodes has been studied in dimethylformamide (DMF), a solvent for polyacrylonitrile (PAN), and in non-solvents that include acetonitrile (ACN), propylene carbonate (PC) and pyridine (PY). Electrografting responsible for the cathode inhibition has been observed for the first time in PC and PY. Not only the polymer-solvent interactions but also the intrinsic polarity of the solvent have an effect on the intensity of the inhibition peak which is the signature of the electrografting reaction. Concentration of the monomer in the electrode double layer appears to decrease as the solvent polarity is increased, consistently with a more efficient displacement of the monomer by a more polar compound. That such a competition occurs is also supported by the effect of the nature and concentration of the conducting salt. The best quality films are formed in DMF, which is a solvent for PAN. Quartz microbalance experiments have emphasized the crucial importance of the potential range used for the AN electroreduction, particularly in a solvent of the polymer. [less ▲]

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See detailField Efficacy of Injectable Doramectin against Chorioptes Bovis in Naturally Infected Cattle
Losson, Bertrand ULg; Mignon, Bernard ULg; Bossaert, K. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 142(1), 18-19

A single subcutaneous injection of doramectin at a dose rate of 200 micrograms/kg bodyweight was effective in controlling an infection of Chorioptes bovis mites in naturally infected cattle. From 14 days ... [more ▼]

A single subcutaneous injection of doramectin at a dose rate of 200 micrograms/kg bodyweight was effective in controlling an infection of Chorioptes bovis mites in naturally infected cattle. From 14 days after treatment, the geometric mean number of live mites was significantly lower (P < 0.001) in the doramectin-treated cattle than in the control group at each sampling until day 35. The percentage efficacy (treated versus controls) of doramectin against C bovis at day 35 was 99.9 per cent and the percentage reduction (day 35 versus day 0) in the treated animals was 99.3 per cent. At day 35, all seven controls were still positive for C bovis whereas five of the eight doramectin-treated animals were free of live mites. [less ▲]

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See detailEffects of Dexamethasone on the Profile of Cytokine Secretion in Human Whole Blood Cell Cultures
Franchimont, Denis; Louis, Edouard ULg; Dewé, Walthère ULg et al

in Regulatory Peptides (1998), 73(1), 59-65

EXPERIMENTAL OBJECTIVES: The interaction between the endocrine and immune systems is a very intriguing area. Endogenous glucocorticoids, as end-effectors of the hypothalamo-pituitary-adrenal axis, inhibit ... [more ▼]

EXPERIMENTAL OBJECTIVES: The interaction between the endocrine and immune systems is a very intriguing area. Endogenous glucocorticoids, as end-effectors of the hypothalamo-pituitary-adrenal axis, inhibit the immune and inflammatory responses and are used as immunosuppressive drugs in many inflammatory, autoimmune and allergic diseases. The aims of this study were to investigate the effects of dexamethasone on the profile of cytokine secretion in whole blood cell cultures from healthy subjects and to analyse the gender-related sensitivity to dexamethasone on each cytokine secretion. RESULTS: There was a significant inhibition by dexamethasone (from 1 to 100 nM) on the secretion of monokines (IL-1beta, IL-6, IL-8 and TNF alpha) and lymphokines (IL-2, IL-4, IL-10 and IFN gamma), either after LPS or PHA stimulation (P < 0.01). Interleukin 4 and IL-10 were less inhibited than IFN gamma (P < 0.05 at 1 nM, P < 0.01 at 10 nM and P < 0.001 from 100 nM to 10 microM). No gender difference was observed in the rate of inhibition of the secretion of each cytokine. CONCLUSION: This study shows that the inhibition of cytokine secretion by dexamethasone is more marked on Th1-type cytokines than on Th2-type cytokines. These data support the idea that glucocorticoids may induce a shift from the Th1 to Th2 profile of cytokine secretion. [less ▲]

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See detailVariations of Ap stars in the Geneva system
Manfroid, Jean ULg; Burnet, M.; Renson, Pierre ULg

in Astronomy and Astrophysics. Supplement Series (1998), 127

The photometric behaviour of 21 Ap stars has been analyzed from observations obtained in the Geneva system. Variability has been detected for 9 Ap stars, as well as for a star which initially was a ... [more ▼]

The photometric behaviour of 21 Ap stars has been analyzed from observations obtained in the Geneva system. Variability has been detected for 9 Ap stars, as well as for a star which initially was a comparison star. Preliminary values for the periods are presented as well as an analytical description of the light curves. based on observations made at the Swiss telescope of the European Southern Observatory, La Silla, Chile. Complete Table 4 is available in electronic form at the CDS via anonymous ftp 130.79.128.5 or http://cdsweb.u-strasbg.fr/Abstract.html and full figures are accessible on the on-line version of the paper. [less ▲]

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See detailReal-time stroboscopic holographic interferometry using sillenite crystals for the quantitative analysis of vibrations
Georges, Marc ULg; Lemaire, Philippe

in Optics Communications (1998), 145

A breadboard holographic interferometer that uses a photorefractive sillenite crystal under anisotropic diffraction configuration is presented for application of quantitative vibration measurements. After ... [more ▼]

A breadboard holographic interferometer that uses a photorefractive sillenite crystal under anisotropic diffraction configuration is presented for application of quantitative vibration measurements. After the hologram of the object at rest is recorded, a stroboscope is used to observe the stable pattern of the vibrating object and phase-shifting is introduced for quantitative measurements. It is shown that this system can measure modal displacements of objects of typically 23×23 cm2 with high accuracy (λ/40) by using a continuous YAG laser emitting 490 mW at 532 nm. The error sources are investigated and particularly a systematic error arising from the stroboscopic process can be calculated and eliminated. [less ▲]

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See detailLattice gas model of gradual evolution
Ausloos, Marcel ULg; Mroz, I.; Pekalski, A. et al

in Physica A: Statistical Mechanics and its Applications (1998), 248(1-2), 155-164

A simple dynamical model is presented for describing the gradual evolution of a variable number of species. The system is studied through Monte Carlo simulations using a lattice gas formalism. Each ... [more ▼]

A simple dynamical model is presented for describing the gradual evolution of a variable number of species. The system is studied through Monte Carlo simulations using a lattice gas formalism. Each species is characterized by a single, scalar parameter ("adaptation") which is changed, within limits depending on the adaptation itself, at each time step. There are two independent mechanisms for removing a species from the system and one for creating a new species. We find that, regardless of the initial concentration of species, the system always reaches the same final state, characterized by the same concentration and the same average adaptation. The system is not homogeneous and contains species with different values of adaptation. The better adapted ones are found to form more symmetrical spatial patterns. Behavior similar to the one determined in the present model has been found in the evolving ecological and biological systems. [less ▲]

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See detailElectrochemistry of N-vinyl-2-pyrrolidone and a non polymerizable analogue
Calberg, Cédric ULg; Kroonen, D.; Mertens, Marc et al

in Polymer (1998), 39(1), 23-29

According to previous studies, the electropolymerization of N-vinyl-2-pyrrolidone fits a cationic mechanism with grafting of the polymer onto the platinum anode. However, this article shows that the ... [more ▼]

According to previous studies, the electropolymerization of N-vinyl-2-pyrrolidone fits a cationic mechanism with grafting of the polymer onto the platinum anode. However, this article shows that the pyrrolidone substituent of N-VP is also involved in the anodic reaction in addition to the polymerizable vinyl double bond. This additional reaction in the potential range of interest was confirmed by the electrochemical oxidation of a non polymerizable analogue of N-VP, i.e. N-methylpyrrolidone. Therefore, at least two mechanisms can contribute to the electrodeposition of a polymer film in a solvent of poly N-VP: electrografting and polymer branching and/or crosslinking by species stemming from the electrooxidation of the pyrrolidone rings. [less ▲]

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See detailA new damper to solve galloping on bundled lines. Theoretical background, laboratory and field results.
keutgen, Renaud; Lilien, Jean-Louis ULg

in IEEE Transactions on Power Delivery (1998), 13(N°1), 260-265

A new kind of anti-galloping device for bundled lines is presented.

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See detailEndothelial Cell Intracellular Ca2+ Concentration Is Increased Upon Breast Tumor Cell Contact and Mediates Tumor Cell Transendothelial Migration
Lewalle, J. M.; Cataldo, Didier ULg; Bajou, Khalid ULg et al

in Clinical & Experimental Metastasis (1998), 16(1), 21-9

Tumor cell extravasation is a determinant step in the process of hematogenous metastasis. The signal transduction pathways involved in the interactions between tumor cells and the vascular endothelium ... [more ▼]

Tumor cell extravasation is a determinant step in the process of hematogenous metastasis. The signal transduction pathways involved in the interactions between tumor cells and the vascular endothelium during transendothelial migration are still undefined. In the present study, we have investigated the influence of human breast adenocarcinoma cells (MCF7) on human umbilical vein endothelial cell (HUVEC) intracellular Ca2+ concentration ([Ca2+]i). We show that the contact between MCF7 cells and a confluent HUVEC monolayer induces an immediate and transient increase in HUVEC [Ca2+]i. This [Ca2+]i rise could not be elicited by tumor cell-conditioned medium, isolated tumor cell membranes, inert beads or normal breast epithelial cells, demonstrating the involvement of specific recognition mechanisms between MCF7 cells and HUVEC. Depletion of HUVEC intracellular Ca2+ stores by the endoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin as well as the selective depletion of inositol 1,4,5-triphosphate (IP3)-sensitive Ca2+ stores by prior activation of HUVEC using histamine resulted in a complete inhibition of tumor cell-induced [Ca2+]i elevation. Similar results were obtained when HUVEC monolayers were treated with the tyrosine kinase inhibitor herbimycin A, suggesting a role for tyrosine kinase-associated cell surface receptors in tumor cell-endothelial cell interactions. The depletion of HUVEC intracellular Ca2+ stores by thapsigargin was also shown to delay MCF7-induced endothelial cell disjunction, to prevent their spreading on the subendothelial extracellular matrix and transendothelial migration in vitro. These results suggest that transient changes in endothelial [Ca2+]i may govern multiple steps of tumor cell extravasation. [less ▲]

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See detailOxidant-Scavenging Activities of Beta-Lactam Agents
Carreer, R.; Deby-Dupont, G.; Deby, C. et al

in European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology (1998), 17(1), 43-6

The relative antioxidant effect of ampicillin, ceftazidime, ceftriaxone, and cefuroxime on oxygen-reactive species was examined in vitro using stimulated human polymorphonuclear neutrophils. There was no ... [more ▼]

The relative antioxidant effect of ampicillin, ceftazidime, ceftriaxone, and cefuroxime on oxygen-reactive species was examined in vitro using stimulated human polymorphonuclear neutrophils. There was no evidence that any of the beta-lactam agents tested had an effect on superoxide or H2O2 generation. In contrast, all of the beta-lactam agents prevented hypochlorous acid (HOCI) chlorination of 1,1-dimethyl-4-chloro-3,5-cyclo-hexanedione in a cell-free system at concentrations of < 10 microg/ml. Furthermore, all antibiotics provided dose-dependent protection against HOCI cytotoxicity to 16HBE140 bronchial epithelial cells. Taken together, these data indicate a possible therapeutic role for beta-lactam agents in protecting host tissues from HOCI-induced oxidative damage. [less ▲]

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See detailPolyimide nanofoams from aliphatic polyester-based copolymers
Hedrick, James L; Carter, K. R.; Richter, R. et al

in Chemistry of Materials (1998), 10(1), 39-49

High-temperature polymeric foams were prepared using compositionally asymmetric microphase-separated block copolymers where the major component is thermally stable and the minor component is thermally ... [more ▼]

High-temperature polymeric foams were prepared using compositionally asymmetric microphase-separated block copolymers where the major component is thermally stable and the minor component is thermally labile. Upon thermal treatment, the dispersed phase undergoes thermolysis leaving pores the size and shape of which are dictated by the initial copolymer morphology. The driving force behind the survey of aliphatic polyesters as possible labile blocks stems from their quantitative degradation into low-boiling, polar degradation products. Poly(lactones), as a general class of materials, degrade by a backbiting process producing, primarily, monomer and cyclic oligomers. A ring-opening synthetic route to poly(lactones) affords oligomers of predictable molecular weight, narrow molecular weight distribution, and controlled end-group functionality. Block copolymers were prepared using monofunctional caprolactone and valerolactone oligomers and a high-Tg polyimide. Microphase separation was observed in all cases, and the lactone blocks did not crystallize. Thermal decomposition of the caprolactone block was accomplished by heating the copolymer to 370 °C for 5 h. Significant density reductions were found with pore sizes in the 60−70 Å range. [less ▲]

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See detailCytological Comparison of Leaves and Stems of Prunus Avium L. Shoots Cultured on a Solid Medium with Agar or Gelrite
Franck, Thierry ULg; Crevecoeur, Michelle; Wuest, J. et al

in Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission (1998), 73(1), 32-43

An axillary proliferating clone of Prunus avium L. was subcultured every four weeks on solid MS medium with agar as the gelling agent. Vitrification (hyperhydricity) of shoots was induced in one four week ... [more ▼]

An axillary proliferating clone of Prunus avium L. was subcultured every four weeks on solid MS medium with agar as the gelling agent. Vitrification (hyperhydricity) of shoots was induced in one four week cycle with the same medium except that agar was replaced by gelrite. During culture on the vitrifying medium, the water content of the shoots progressively increased with a parallel decrease in chlorophyll content. Cytological differences between the leaves and stems of the vitrified and normal shoots were detected by light and electron (both transmission and scanning) microscopy. Leaves of vitrified shoots were characterized by lower number of chloroplasts in the palisade parenchyma and by a defective cuticle. The stems of vitrified shoots had a less developed and lignifled xylem tissue, lacked sclerenchymatic areas and showed hypertrophy of the cortical parenchyma. More intense vacuolar activity with evaginations of the chloroplast envelope into the vacuole was noted in cells of vitrified leaves. [less ▲]

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See detailInverse Modulation of Il-10 and Il-12 in the Blood of Women with Preneoplastic Lesions of the Uterine Cervix
Jacobs, Nathalie ULg; Giannini, Sandra L; Doyen, Jean ULg et al

in Clinical & Experimental Immunology (1998), 111(1), 219-24

It has been postulated that an impaired immune response may contribute to the progression of human papillomavirus (HPV)-associated preneoplastic lesions. Based on this hypothesis, we evaluated the ... [more ▼]

It has been postulated that an impaired immune response may contribute to the progression of human papillomavirus (HPV)-associated preneoplastic lesions. Based on this hypothesis, we evaluated the cytokine production in the blood of patients with squamous intraepithelial lesions (SIL) of the uterine cervix. The levels of type-1 (interferon-gamma (IFN-gamma) and IL-12) and type-2(IL-4 and IL-10) cytokines were measured in whole blood culture supernatants of patients with low- and high-grade SIL and control women. There was no difference in IL-4 and IFN-gamma levels between patients with SIL and the control group. In contrast, the ratio of IL-12/IL-10 levels was significantly lower in patients with SIL compared with the control group. A lower IL-12/IL-10 ratio in women with SIL was also observed when peripheral blood mononuclear cell (PBMC) culture supernatants and plasma samples were analysed. In patients, neither the lower expression of the CD3epsilon chain nor the higher frequency of HLA-DRB1*1501 expression could be correlated with abnormal cytokine production. These results suggest that a part of the cytokine network, namely IL-10 and IL-12, is perturbed in patients with SIL. A better knowledge of the role of these cytokines in regulating the growth of HPV-associated SIL might have practical implications for the development of vaccines or immunomodulatory strategies in the treatment of cervical cancers. [less ▲]

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See detailLa couverture 1998 de la Revue medicale de Liège: histoplasmose chez un sidéen
Pierard, Gérald ULg

in Revue Médicale de Liège (1998), 53(1), 2-3

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See detailSelf-organized criticality can emerge even if the range of interactions is infinite
Vandewalle, Nicolas ULg; Van Puyvelde, H.; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1998), 57(1), 1167-1170

We have investigated a model of tree growth in order to show that self-organized criticality (SOC) can emerge even if perturbations due to long-range interactions are propagating throughout the whole ... [more ▼]

We have investigated a model of tree growth in order to show that self-organized criticality (SOC) can emerge even if perturbations due to long-range interactions are propagating throughout the whole system. The interaction potential is assumed to be a power d(-alpha) of the distance d measured along the tree between branch extremities. A transition occurs for alpha(c)=1 according to simulation results between SOC (alpha>alpha(c) and non-SOC (alpha<alpha(c)) regimes. A theoretical treatment supports the idea that the transition occurs when the exponent a is equivalent to the fractal dimension D-f(S) of the backbone (skeleton) of the tree. [less ▲]

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See detailThe isothermal melt-texturing of bulk YBa2Cu3O7-x ceramics: from cooking to modelling
Vandewalle, Nicolas ULg

in Superconductor Science and Technology (1998), 11(1), 35-43

Various techniques for the synthesis of bulk YBa2Cu3O7-x ceramics are reviewed. The microstructure of melt-textured YBa2Cu3O7-x compounds is described. In contrast to the relatively simple processing of ... [more ▼]

Various techniques for the synthesis of bulk YBa2Cu3O7-x ceramics are reviewed. The microstructure of melt-textured YBa2Cu3O7-x compounds is described. In contrast to the relatively simple processing of such materials, the complexity of the microstructure at a mesoscopic scale is underlined. A model describing the various features of the microstructure of YBa2Cu3O7-x compounds is described. The obtained results are discussed for various initial conditions and are favourably comparable with experimental findings. [less ▲]

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See detailLe cas clinique du mois. A propos d'une fièvre inexpliquée
Bustin, F.; Kolh, Philippe ULg; Creemers, Etienne ULg et al

in Revue Médicale de Liège (1998), 53(1), 7-10

An episode of fever of prolonged duration and undetermined origin always remains a difficult clinical problem. Several etiologies can indeed be responsible. If one wishes to obtain a diagnosis of the ... [more ▼]

An episode of fever of prolonged duration and undetermined origin always remains a difficult clinical problem. Several etiologies can indeed be responsible. If one wishes to obtain a diagnosis of the origin of the fever, one should adopt a well-structured strategy in which the various investigations are carried out in a strictly determined hierarchical order. This is badly needed if one wishes to reach a clue to the diagnosis and be able to implement an adequate therapy. In spite of all this, some cases will remain without precise diagnosis. The treatment of those cases will primary be empirical. [less ▲]

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See detailA Breadboard Holographic Interferometer with Photorefractive Crystals and Industrial Applications
Georges, Marc ULg; Lemaire, Philippe

in SPIE's International Technical Working Group Newsletter : Holography (1998), 9(1), 9

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See detailcompte rendu de l'ouvrage de D. Porter (éd.), The History of Public Health and the Modern State, Amsterdam-Atlanta, 1994
Marganne, Marie-Hélène ULg

in Archives Internationales d'Histoire des Sciences (1998), 48

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See detailTransportable holographic interferometer uses photorefractive crystals for industrial applications
Georges, Marc ULg; Lemaire, Philippe

in SPIE's OE Reports (1998)

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See detailAlcool, drogues, médicaments et sécurité routière en Belgique. Belgian Toxicology and Trauma Study Research Group
Charlier, Corinne ULg; Plomteux, Guy ULg

in Revue Médicale de Liège (1998), 53(1), 25-8

The BTTS study (Belgian Toxicology and Trauma Study) was performed in Belgium between January 15th 1995 and June 15th 1996. The purpose was to investigate how frequently the drivers involved in road ... [more ▼]

The BTTS study (Belgian Toxicology and Trauma Study) was performed in Belgium between January 15th 1995 and June 15th 1996. The purpose was to investigate how frequently the drivers involved in road accidents were driving under the influence of psychotropic drugs. Two thousand fifty-three blood tests were performed of which 207 in the Liege region. The results obtained at the national level are compared to those obtained at the level of the Liege region. In both cases, the BTTS study allows the conclusion that a considerable proportion of drivers involved in road accidents resulting in significant traumatic consequences were driving under the influence of substances with psychotropic properties. [less ▲]

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See detailLes affections médicales qui interfèrent avec la grossesse
Thoumsin, H. J.; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (1998), 53(1), 1-14

During pregnancy, the future mother can develop several different diseases. Most of them have a benign prognosis. Cyanotic heart disease, at least when it is accompanied by significant pulmonary ... [more ▼]

During pregnancy, the future mother can develop several different diseases. Most of them have a benign prognosis. Cyanotic heart disease, at least when it is accompanied by significant pulmonary hypertension or induces a functional class IV represents a contra-indication to pregnancy. Pregnancy cardiomyopathy generally carries a poor prognosis and may be responsible for the mother's death. Herpes virus pneumopathy can also be extremely dangerous. Lupus erythematosus represents a factor of guarded prognosis for the outcome of pregnancy; discontinuation of the latter should be seriously considered. Hepatic steatosis which is a rare diagnosis must be distinguished from Hellp syndrome in which the maternal prognosis is much better. In this review, we shall briefly discuss various medical diseases which may have a deleterious influence on the evolution of pregnancy or on the foetus. These deleterious influences can be direct, i.e. due to the disease, or indirect, i.e. due to the therapy. We shall successively consider several neurological, cardiological, pulmonary, dermatological and digestive diseases. We shall not take into account viral infections or infections in general, diabetes mellitus or the various vasculo-renal syndromes. [less ▲]

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See detailThe C-terminal helix of human apolipoprotein AII promotes the fusion of unilamellar liposomes and displaces apolipoprotein AI from high-density lipoproteins.
Lambert, Géraldine ULg; Decout, A.; Vanloo, B. et al

in European Journal of Biochemistry (1998), 253(1), 328-38

To assess the functional properties of apolipoprotein (apo) AII and to investigate the mechanism leading to the displacement of apo AI from native and reconstituted high-density lipoproteins (HDL and r ... [more ▼]

To assess the functional properties of apolipoprotein (apo) AII and to investigate the mechanism leading to the displacement of apo AI from native and reconstituted high-density lipoproteins (HDL and r-HDL) by apo AII, wild-type and variant apo AII peptides were synthesized. The wild-type peptides, residues 53-70 and 58-70, correspond to the C-terminal helix of apo AII and are predicted to insert at a tilted angle into a lipid bilayer. We demonstrate that both the apo AII-(53-70) peptide, and to a lesser extent the apo AII-(58-70) peptide are able to induce fusion of unilamellar lipid vesicles together with membrane leakage, and to displace apo AI from HDL and r-HDL. Two variants of the apo AII-(53-70)-wild-type (WT) peptide, designed either to be parallel to the water/lipid interface [apo AII-(53-70)-0 degrees] or to retain an oblique orientation [apo AII-(53-70)-30 degrees], were synthesized in order to test the influence of the obliquity on their fusogenic properties and ability to displace apo AI from HDL. The parallel variant did not bind lipids, due to its self-association properties. However, the apo AII-(53-70)-30 degrees variant was fusogenic and promoted the displacement of apo AI from HDL. Moreover, the extent of fusion of the apo AII-(53-70)-WT, apo AII-(58-70)-WT and apo AII-(53-70)-30 degrees peptides was related to the alpha-helical content of the lipid-bound peptides measured by infrared spectroscopy. Infrared measurements using polarized light also confirmed the oblique orientation of the helical component of the three peptides. In native and r-HDL, the tilted insertion of the C-terminal helix of apo AII resulting in a partial destabilization of the HDL external lipid layer might contribute to the displacement of apo AI by apo AII. [less ▲]

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See detailHsv-1 Thymidine Kinase Gene Therapy for Peritoneal Carcinomatosis
Lechanteur, Chantal ULg; Princen, Frédéric; Lo Bue, S. et al

in Advances in Experimental Medicine and Biology (1998), 451

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See detailFoaming properties of lipopeptides produced by Bacillus subtilis: effect of lipid and peptide structural attributes
Razafindralambo, Hary ULg; Popineau, Yves; Deleu, Magali ULg et al

in Journal of Agricultural and Food Chemistry (1998), 46(3), 911-916

To study the effect of lipid and peptide structural attributes of Bacillus subtilis lipopeptides on their foaming properties, the formation, stability, and appearance of foams prepared with surfactins ... [more ▼]

To study the effect of lipid and peptide structural attributes of Bacillus subtilis lipopeptides on their foaming properties, the formation, stability, and appearance of foams prepared with surfactins (C13 C15) and iturins A (C14 C17) were characterized. The density and stability of lipopeptide foams depend on both the alkyl chain hydrophobic character and peptide molecular intrinsic properties. A lipidic chain length of 14 carbon atoms provides lipopeptides with the best foaming properties in terms of foam density and liquid stability in foams. Increases in alkyl chain length above 15 carbon atoms result in a drastic decrease of iturin A foam density. With the same alkyl chain, surfactin produces denser foam whereas iturin A exhibits better foaming stability. These results demonstrate the importance of the peptide structural attributes of B. subtilis on their foaming properties. [less ▲]

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See detailRadiative transition probabilities for forbidden lines in singly ionized cobalt (Co II)
Quinet, Pascal ULg

in Astronomy and Astrophysics. Supplement Series (1998), 129

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See detailIdentification of a fossil wood specimen in the Red Sandstone Group of Southwestern Tanzania: stratigraphical and tectonic implications.
Damblon, Freddy ULg; Gerrienne, Philippe ULg; Doutrelepont, Hughes et al

in Journal of African Earth Sciences (1998), 26

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See detailUltrastructural nucleolar alterations induced by an ametantrone--poly r(A-U) complex.
Jamison, J. M.; Gilloteaux, J.; Thiry, Marc ULg et al

in Tissue & Cell (1998), 30(4), 475-84

The current study has documented changes in the ultrastructure as well as in the intranucleolar distribution of rDNA and rRNA in RT4 (human transitional cell bladder carcinoma) cell nucleoli following a 3 ... [more ▼]

The current study has documented changes in the ultrastructure as well as in the intranucleolar distribution of rDNA and rRNA in RT4 (human transitional cell bladder carcinoma) cell nucleoli following a 3-h exposure to toxic doses of 50 microM ametantrone (AMT), 200 microM poly (adenylate-uridylate) (poly r(A-U) or an AMT/poly r(A-U) combination with an AMT/polyribonucleotide ratio of 1:4 and a poly r(A-U) concentration of 200 microM. While the main nucleolar components (fibrillar center (F), dense fibrillar component (D), granular component (G) and interstices (I) can be discerned following all treatments, the nucleoli exhibit: compaction, segregation, a decrease in the number of F, an increase in the size of remaining F, margination of intranucleolar chromatin and retention of intranucleolar pre-rRNA and rRNA. The relative abilities of the test agents to induce nucleolar compaction are AMT/poly r(A-U) > poly r(A-U) > AMT > sham-treated, while the abilities of the test agents to induce the remaining nucleolar changes are AMT/poly r(A-U) > or = AMT > poly r(A-U) > sham-treated cells. Poly r(A-U) and the induced interferon induce nucleolar compaction, while AMT produces nucleolar segregation. These results are consistent with a model in which the poly r(A-U) and/or the AMT inhibit DNA transcription and rRNA processing as well as the release of nascent preribosomes from the nucleolus. [less ▲]

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See detailIsolation Of Highly Performant Sulfate Reducers From Sulfate-Rich Environments
Hiligsmann, Serge ULg; Jacques, Philippe; Thonart, Philippe ULg

in Biodegradation (1998), 9(3-4), 285-292

Eleven pure strains of sulfate-reducing bacteria have been isolated from lab-scale bioreactors or disposal sites, all featuring relatively high concentrations of sulfate, and from natural environments in ... [more ▼]

Eleven pure strains of sulfate-reducing bacteria have been isolated from lab-scale bioreactors or disposal sites, all featuring relatively high concentrations of sulfate, and from natural environments in order to produce sulfide from gypsum using hydrogen as energy source. The properties of the eleven strains have been investigated and compared to these of three collection strains i.e. Desulfovibrio desulfuricans and vulgaris and Desulfotomaculum orientis. Particular attention was paid to the absolute and relative sulfide production rate and to the hydrogen sulfide inhibition level. By comparison to the collection strains, a 75 % higher production rate and a hydrogen sulfide inhibition level about twice higher i.e. 25.1 mM have been achieved with strains isolated from sulfate-rich environments. The strain selection, particularly from sulfate-rich environments, should be considered as an optimization factor for the sulfate reduction processes. [less ▲]

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See detailNumber and relative size of thenar motor units in ALS patients: application of the adapted multiple point stimulation method.
Wang, François-Charles ULg; Delwaide, Paul ULg

in Electroencephalography and Clinical Neurophysiology (1998), 109(1), 36-43

In the present study, the adapted multiple point stimulation (AMPS) method was first applied to median innervated thenar muscles in 22 amyotrophic lateral sclerosis (ALS) patients who did not received any ... [more ▼]

In the present study, the adapted multiple point stimulation (AMPS) method was first applied to median innervated thenar muscles in 22 amyotrophic lateral sclerosis (ALS) patients who did not received any treatment. In all patients, a motor unit number estimate (MUNE) and an average surface-recorded motor unit action potential (S-MUAP) size have been derived even if the denervation was severe; and the results were reproducible. The thenar MUNE was less than the normal lower limit for age in 17 patients, and the mean MUNE (67.1 +/- 90.6) was significantly different from that estimated in control subjects (263.3 +/- 116.8). The mean S-MUAP size in the 22 ALS patients was 352.9 +/- 328.4 microV x ms versus 94.1 +/- 30.3 microV x ms in healthy volunteers. A control AMPS was achieved in 8 patients after 2 and 6 months of a glutamate-release antagonist (riluzole) treatment. The mean loss of motor units, based on control thenar MUNEs realized after 6 months of treatment, was 53%. In conclusion, we propose AMPS as a manageable, reproducible and non-invasive procedure which permits one to quantify peripheral denervation and to appreciate the effectiveness of collateral reinnervation in ALS patients. [less ▲]

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See detailDifferent periods of feed restriction before compensatory growth in Belgian Blue bulls: II. Plasma metabolites and hormones
Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg; Diez, Marianne ULg et al

in Journal of Animal Science (1998), 76(1), 260-271

Plasma metabolites and hormones were studied in 16 double-muscled Belgian Blue bulls maintained at low growth (.5 kg/d) for 114 (G2), 243 (G3), or 419 (G4) d (low growth period, LGP) before fattening ... [more ▼]

Plasma metabolites and hormones were studied in 16 double-muscled Belgian Blue bulls maintained at low growth (.5 kg/d) for 114 (G2), 243 (G3), or 419 (G4) d (low growth period, LGP) before fattening (rapid growth period, RGP). Animals from the control group (CG) were fed a diet high in energy and protein. The animals from G2, G3, and G4 were fed a restricted amount of a diet low in energy and protein during LGP and the same diet as CG during RGP. Plasma glucose, alpha-amino nitrogen (AAN), NEFA, urea, creatinine, thyroxine (T4), 3,3',5'-triiodothyronine (T3), and IGF-I were measured in blood samples taken fortnightly. Plasma GH and insulin (I) profiles were measured in serial blood samples obtained at three times during growth. The RGP was characterized by an initial compensatory growth, by higher plasma glucose, AAN, and urea levels, and by lower plasma NEFA and creatinine levels. Plasma GH concentration decreased after refeeding. Plasma T4 increased linearly during refeeding, as opposed to T3, which showed a different profile in each group. Plasma IGF-I showed a curvilinear increase during RGP and reached a plateau after 3 mo in each compensating group. In G4, changes of plasma metabolites and hormones differed often distinctly from G2 or G3. During refeeding, higher nutrient supply improved the functionality of the somatotropic axis and increased the concentration of anabolic hormones, allowing rapid muscle deposition. However, animals underfed the longest period behaved differently from the other groups, possibly because they reached a more complete sexual maturity. [less ▲]

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See detailReciprocal regulation of protein tyrosine kinases p56lck and p59fyn, and altered tyrosine phosphorylation in murine AIDS.
Trebak, Mohamed; Lambert, Chantal ULg; Rahmouni, Souad ULg et al

in International Immunology (1998), 10(10), 1473-80

Murine AIDS (MAIDS), caused by a defective murine leukemia virus, is a severe lymphoproliferative disease associated with profound immunodeficiency and increased susceptibility to opportunistic infections ... [more ▼]

Murine AIDS (MAIDS), caused by a defective murine leukemia virus, is a severe lymphoproliferative disease associated with profound immunodeficiency and increased susceptibility to opportunistic infections. Most subsets of lymphocytes, including CD4+ and CD8+ T cells, are refractory to mitogen stimulation. As a first step to examine proximal signal transduction in the infected mice, Western and Northern blot analyses were performed, and showed that p56lck is dramatically decreased at the protein as well as the mRNA level in the lymph nodes (LN). In contrast, p59(fyn) and its mRNA were slightly increased in the LN of the same mice. Similar results were obtained with purified T cells. Interestingly, the thymus of the infected animals did not show any abnormality regarding p56(lck) or p59(fyn). Tyrosine phosphorylation was constitutively increased in the infected mice and was barely amplified by anti-CD3 mAb stimulation. A similar pattern was observed when tyrosine phosphorylation was selectively examined at the level of ZAP-70. Our results suggest that a reciprocal regulation of p56(lck) and p59(fyn) protein tyrosine kinases, previously described in various models of anergy, could also be involved in the pathogenesis of MAIDS. [less ▲]

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See detailPlaidoyer pour la biodiversité au crépuscule du deuxième millénaire.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (1998), 55

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See detailSpéléothèmes des karsts siliceux du Niger et du Cameroun
Willems, Luc ULg; Compère, Philippe ULg; Sponholz, Barbara et al

in Géosciences au Cameroun & collection Géocam (1998), 1

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See detailProduction and kinematics of sodium atoms in the coma of comet Hale-Bopp
Arpigny, Claude ULg; Rauer, H.; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (1998), 334(Letters), 53-56

High-resolution spectra of sodium D line emission in comet Hale-Bopp (C/1995 O1) were obtained at the Observatoire de Haute-Provence, France, on 25-27 March and on 15-17 April, 1997. The observations have ... [more ▼]

High-resolution spectra of sodium D line emission in comet Hale-Bopp (C/1995 O1) were obtained at the Observatoire de Haute-Provence, France, on 25-27 March and on 15-17 April, 1997. The observations have been used to measure the velocity of sodium atoms in the coma within 2 10(5) km from the nucleus. A comparison between the March and April data provides an illustration of the influence of the heliocentric radial velocity on the strength of the fluorescence (Swings effect), and on the velocity of Na atoms achieved by solar radiation pressure acceleration. Evidence for the presence of a distributed source in the coma is found from the relatively high tailward velocities on the sunward side of the coma, in addition to the sunward extent of sodium emission up to 1.4 10(5) km in April. Based on observations secured at OHP (France) [less ▲]

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See detailCanonical variables of aquatic bryophyte combinations for predicting water trophic level
Vanderpoorten, Alain ULg; Palm, R.

in Hydrobiologia (1998), 386(1-3), 85-93

A method for predicting water quality by linear regression using aquatic bryophy te canonical variables as predictors is presented. An example of application in the Alsatian Rhine valley is developed. The ... [more ▼]

A method for predicting water quality by linear regression using aquatic bryophy te canonical variables as predictors is presented. An example of application in the Alsatian Rhine valley is developed. The /--squared obtained before and after cross-validation reached 0.68 and 0.58 for the standard deviation of temperatures, 0.55 and 0.46 for the logarithm of the mean concentrations of N-NH4+, 0.52 and 0.43 for the logarithm of the mean concentrations of N-NO3- and 0.38 and 0.31 for the logarithm of the mean concentrations of P-PO43-. Higher r-squared were not expected due to the broad physico-chemical ranges and the low diversity of genuine aquatic bryophytes. The predicted values of the mean concentrations of N-NH4+, P-PO43- and of the standard deviation of temperatures were often greater than the measured ones. The aquatic bryophytes integrate the sudden increase of the trophic level in oligotrophic streams during the floods of the main eutrophic river and testify to a higher trophic level than expected from regular physico-chemical analyses outside the flood period. Aquatic bryophytes are also affected by water quality in the long term and indicate pollutants other than those measured in current water quality. Other factors besides trophic level might influence the aquatic bryophyte assemblages and should be monitored in order to find the precise relationships between water quality and aquatic macrophytes and in order to create a more accurate model of the effects of the flooding of disconnected streams by the Rhine waters (currently in progress in the Upper Rhine) on the aquatic macrophyte assemblages. [less ▲]

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See detailTumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.
Louis, Edouard ULg; Franchimont, D.; Piron, Anne ULg et al

in Clinical & Experimental Immunology (1998), 113(3), 401-406

TNF-alpha is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-alpha production. This might determine a predisposition to develop some ... [more ▼]

TNF-alpha is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-alpha production. This might determine a predisposition to develop some complications or phenotypes of these diseases. The aims of our study were to assess the inter-individual variability of TNF-alpha production and to correlate this variability to a single base pair polymorphism located at position -308 in TNF gene. We studied 62 healthy individuals. TNF-alpha production after LPS stimulation was evaluated using a whole blood cell culture model. The TNF gene polymorphism was studied by an allele-specific polymerase chain reaction. Other cytokines produced in the culture, soluble CD14 concentrations and expression of CD14 on blood cells were also measured. Among the 62 individuals, 57 were successfully genotyped. There were 41 TNF1 homozygotes and 16 TNF1/TNF2 heterozygotes. TNF-alpha production after LPS stimulation of whole blood cell culture was higher among TNF2 carriers than among TNFI homozygotes (929pg/ml (480-1473pg/ml) versus 521 pg/ ml (178-1307 pg/ml); P<0.05). This difference was even more significant after correction of TNF-alpha production for CD14 expression on blood cells. In conclusion, the single base pair polymorphism at position -308 in the TNF gene may influence TNF-alpha production in healthy individuals. [less ▲]

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See detailL'enseignement de la chimie aux étudiants du secondaire qui se destinent à l'université: Trois heures de chimie valent mieux qu'une
Cornélis, André ULg; Cahay, René ULg; Leyh, Bernard ULg

in Chimie Nouvelle (1998), 16

The major importance of a high quality chemistry education in secondary schools is highlighted by the analysis of the results of a procedure developed at the University of Liège to help the students ... [more ▼]

The major importance of a high quality chemistry education in secondary schools is highlighted by the analysis of the results of a procedure developed at the University of Liège to help the students starting their university education, to evaluate their level of basic chemistry competences and to improve them if necessary. It turns out that students who followed three weekly periods of chemistry per week in the secondary school are clearly favoured compared to those who had only one period. These discrepancies show up not only on the starting competence level but also on the progress realized during the remediation step. The starting competence level influences also the strategy chosen by the student for his/her individual remediation. [less ▲]

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See detailBronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bone marrow transplantation.
Baron, Frédéric ULg; Hermanne, Jean-Philippe; Dowlati, A. et al

in Bone Marrow Transplantation (1998), 21(9), 951-4

A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT ... [more ▼]

A 37-year-old man with acute myeloblastic leukemia in first remission developed ulcerative colitis and bronchiolitis obliterans organizing pneumonia (BOOP) 7 months after bone marrow transplantation (BMT) from an HLA-matched brother who suffered from severe Crohn's disease. BOOP occurred 20 days after idiopathic interstitial pneumonia, in the context of severe ulcerative colitis. Lung and colon biopsies showed no signs of CMV infection or GVHD. The patient was treated with oral methylprednisolone 1 mg/kg/day and his clinical status and chest X-ray improved slowly. Remarkably, the symptoms of colitis also resolved with prednisone therapy and he is now symptom-free. We hypothesize that ulcerative colitis may have been transmitted from donor to recipient (adoptive autoimmunity) and that it was complicated by BOOP. However, other factors such as CMV may have contributed to the occurrence of BOOP. [less ▲]

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See detailLes inventaires forestiers de gestion : quels objectifs et quelles méthodes ?
Rondeux, Jacques ULg

in Schweizerische Zeitschrift für Forstwesen = Journal Forestier Suisse (1998), 149(6), 463-473

For each forest which has to be managed, the forest enterprise needs informations dealing with history, ecological and economic environment, silviculture and various descriptions of the wooded area. In ... [more ▼]

For each forest which has to be managed, the forest enterprise needs informations dealing with history, ecological and economic environment, silviculture and various descriptions of the wooded area. In order to record the data and to determine the appropriate inventory method, special attention must first be given to the kind of objectives to be reached (growing stock state, type of silviculture, evolution over time, ... ). Different methods (remote sensing, description of compartments, complete enumeration, sampling inventory, inventory based upon forest typology - and the main constraints of their application are presented as well as some typical illustrated examples. [less ▲]

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See detailPathogenesis of abdominal aortic aneurysm (AAA) formation.
Limet, Raymond ULg; Richelle, Betty ULg; VERLOES, Alain ULg et al

in Acta Chirurgica Belgica (1998), 98(5), 195-8

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See detailValidation of impulse oscillometry in Friesian and Blue Belgian calves with respect to changes in extrathoracic upper airway resistance
Reinhold, Petra; Smith, H.-J.; Close, Roland et al

in Research in Veterinary Science (1998), 65

Impulse oscillometry (IOS) was compared with conventional pulmonary function techniques (using oesophageal balloon and airflow measurements). Healthy Friesian (FR) and Blue Belgian (BB) calves were ... [more ▼]

Impulse oscillometry (IOS) was compared with conventional pulmonary function techniques (using oesophageal balloon and airflow measurements). Healthy Friesian (FR) and Blue Belgian (BB) calves were examined in different conditions of extrathoracic airway resistance (physiological and vertical head position). Higher resistance values were detected in BB calves compared with FR calves with both conventional and forced oscillation techniques in both head positions. Upper airway narrowing was characterised by increasing resistance values without changes in frequency dependence. Measuring input impedance in animals using a face mask, a considerable capacitive shunt of the upper airways (including the capacitive components of the mask) has to be taken into account. Even if the absolute value of this capacitive component is constant, its influence on the measurement results increases with growing frequency and with an increase in upper airway resistance. In conclusion, (1) impulse oscillometry is sensitive to upper airway resistance changes and (2) face mask capacitance is important and has frequency dependent effects on the respiratory impedance. [less ▲]

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See detailPhenologie des Basidiomycetes lignicoles de l'ile de Laing (Papouasie Nouvelle-Guinee)
Castillo Cabello, Gabriel ULg; Demoulin, Vincent ULg

in Belgian Journal of Botany (1998)

In the framework of a study of wood-inhabiting fungi on Laing Island, a small coral island located on the northern coast of Papua New Guinea, we have established a phenological table of the 96 taxa of ... [more ▼]

In the framework of a study of wood-inhabiting fungi on Laing Island, a small coral island located on the northern coast of Papua New Guinea, we have established a phenological table of the 96 taxa of encountered Basidiomycetes. Within six species presenting large phenological amplitude, two groups can be distinguished. On the one hand a group of species (Hexagonia tenuis, Polyporus philippinensis and Microporus xanthopus) with narrow ecological amplitude restricted to dense vegetation cover and thus growing in an environment buffered against desiccation and on the other hand a group of species (Pycnoporus sanguineus, Schizophyllum commune and Trametes scabrosa) with a very large ecological amplitude very resistant to desiccation. Furthermore, a large number of species are found too sporadically in order to draw some conclusions concerning their phenology. [less ▲]

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See detailEvaluation of false ultrasonographic pregnancy diagnoses in cows by measuring plasma levels of bovine pregnancy-associated glycoprotein 1 (bPAG1).
Szenci, Otto; Taverne, M. A. M.; Beckers, Jean-François ULg et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 142(2), 304-306

Between days 27 and 59 after artificial insemination (AI),189 ultrasonographic pregnancy diagnoses were made in 56 dairy cows using a 7·5 MHz linear-array rectal transducer. Blood samples were withdrawn ... [more ▼]

Between days 27 and 59 after artificial insemination (AI),189 ultrasonographic pregnancy diagnoses were made in 56 dairy cows using a 7·5 MHz linear-array rectal transducer. Blood samples were withdrawn from a jugular vein on the day of AI, on day 21, and after each ultrasonographic examination between days 27 and 31, days 34 and 38, days 41 and 45 and days 55 and 59 after AI. Plasma concentrations of bovine pregnancy-associated glycoprotein 1 (bPAG-1) were measured by radioimmunoassay. The results showed that before day 31, ultrasonographic scanning was not very sensitive because six of the 30 calving cows were incorrectly diagnosed as non-pregnant. In five of these animals, the uterus was located far cranial to the pelvic inlet. Five of the cows examined between days 27 and 31 were pregnant on the basis of plasma bPAG-1 levels on the same day, using 0·5 ng/ml as the cut-off point. Plasma levels of bPAG-1 and progesterone proved that four of the cows which had early positive ultrasonographic diagnoses but did not produce a calf, were pregnant when they were examined. [less ▲]

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See detailReconnaissance of the main Black Sea's ecohydrodynamics by means of a 3D interdisciplinary model
Grégoire, Marilaure ULg; Beckers, Jean-Marie ULg; Nihoul, Jacques ULg et al

in Journal of Marine Systems (1998), 16(1-2), 85-105

A 3D interdisciplinary model has been used to test the sensitivity of the Black Sea’s ecosystem to physical processes. The hydrodynamical model of the general circulation has been built up, using the GHER ... [more ▼]

A 3D interdisciplinary model has been used to test the sensitivity of the Black Sea’s ecosystem to physical processes. The hydrodynamical model of the general circulation has been built up, using the GHER primitive equation model. A model with 15 km horizontal resolution and 25 vertical levels is used to compute the typical seasonal cycle. The model is forced by climatological monthly mean fields of temperature, salinity and wind stress at the air–sea interface; the river discharges of the Danube, Dnestr and Dnepr are taken into account. An ecosystem model at basin scale is then defined by a nitrogen cycle considering several phytoplankton and zooplankton sizes and including the microbial loop. The ecosystem model is embedded on-line into the 3D hydrodynamical model with a superimposed cycle for the light intensity. This model must be regarded rather as a first tool for testing the coupling of hydrodynamic and ecosystem submodels, while acquiring some preparatory assessment of the effect of physical processes on the ecodynamics. The results display a highly three-dimensional aspect with important horizontal and vertical variations, obviously imparted to the system by the physical processes horizontal and vertical advection, vertical mixing and diffusion, upwelling associated with light limitation at depth and sinking of dead organisms. In this paper, the results are described emphasizing the effects of the hydrodynamic constraints on the space–time distribution of the primary and secondary production. [less ▲]

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See detailArbres fruitiers et virus: le diagnostic moleculaire.
Kummert, J.; Lepoivre, Philippe ULg

in Agricontact (1998), (302),

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See detailAlcoholic liver disease: how to detect alcoholism?
Delwaide, Jean ULg

in Problem solving in hepatobiliary diseases (1998)

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See detailLa glycoprotéine gE de l'herpèsvirus bovin de type 1 et les nouveaux vaccins marqués
Schynts, Frédéric; Lemaire, Mylène; Baranowski, Eric et al

in Annales de Médecine Vétérinaire (1998), 142

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See detailMeasurement of respiratory impedance in healthy calves using the impulse oscillation technique - physiological and methodological aspects
Reinhold, Petra; Smith, H.-J.; Langenberg, Annelie et al

in Veterinary Journal (1998), 155(1), 27-38

The aim of the present study was to investigate methodological and physiological aspects of complex respiratory impedance measurements in calves using the impulse oscillation technique. To apply the ... [more ▼]

The aim of the present study was to investigate methodological and physiological aspects of complex respiratory impedance measurements in calves using the impulse oscillation technique. To apply the system to animals, a tightly fitting face mask was used. The measuring system was modified by placing a flexible tube between the pneumotachograph and the loudspeaker. Complex respiratory impedance measurements were not significantly influenced by the modification. Linear correlations were found between body weight and respiratory impedance; as body weight increased, resistance decreased and reactance increased. The methodological variability of impedance measurements using the impulse technique was found to be extremely small. Diurnal variations of respiratory impedance were considered to be the main source of intra-individual variability. When comparing different animals (even when healthy and matched for age and body weight) our results suggest that inter-individual biological variability must be carefully considered [less ▲]

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See detailSensitive detection of apple stem grooving and apple stem pitting viruses from infected apple trees by RT-PCR
Kummert, Jean; Marinho, Véra Lucia; Rufflard, Gladys ULg et al

in Acta Horticulturae (1998), 472

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See detailLes hypertensions artérielles d'origine endocrinienne.
Beckers, Albert ULg

in Tempo Médical (1998), 196

Les hypertensions artérielles d'origine endocrinienne représentent environ 3 à 5 % des hypertensions artérielles, parmi lesquelles les formes les plus sévères. Lors du diagnostic, une importance ... [more ▼]

Les hypertensions artérielles d'origine endocrinienne représentent environ 3 à 5 % des hypertensions artérielles, parmi lesquelles les formes les plus sévères. Lors du diagnostic, une importance particulière sera accordée à une sémiologie évocatrice. Une cause endocrinienne sera également activement recherchée dans les cas de mauvaises réponses au traitement classique de l'hypertension artérielle. [less ▲]

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See detailQuarante ans d'exécution de remembrements ruraux en Région wallonne.
Schmitz, Serge ULg; Christians, Charles ULg

in Acta Geographica Lovaniensia (1998), 37

For forty years, a third of the farming area has been regrouped in Wallonia. The paper draws the development of land consolidation and underlines the increase of non agricultural aims, especially ... [more ▼]

For forty years, a third of the farming area has been regrouped in Wallonia. The paper draws the development of land consolidation and underlines the increase of non agricultural aims, especially environment concerns. So land consolidations with stark productivity concerns in the sixties changed to a new way of land consolidation respectful of the inherited balances and concerned with the functional diversification of the rural areas. However the distribution of land consolidation projects still shows stark productivity concerns : land consolidation projects remain first in ploughed land areas with large farming. [less ▲]

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See detailSciences et Médecine à Liège à l'aube du troisième millénaire
Legros, Willy ULg; Rentier, Bernard ULg

in M S-Médecine Sciences (1998), 14(5), 535-536

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See detailDevelopment of colorimetric RT-PCR tets for apple stem grooving virus detection in apple trees
Daniels, J.; Marinho, Véra Lucia; Kummert, Jean et al

in Acta Horticulturae (1998), 472

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See detailRegulation of major histocompatibility complex class I expression by NF-kB-related proteins in breast cancer cells
Dejardin, Emmanuel ULg; Deregowski, Valérie; GREIMERS, Roland ULg et al

in Oncogene (1998)

Downregulation of MHC Class I antigens has been observed in many cancers and usually results from a decreased gene transcription. A reporter CAT gene dependent on the MHC Class I kB site or on a longer ... [more ▼]

Downregulation of MHC Class I antigens has been observed in many cancers and usually results from a decreased gene transcription. A reporter CAT gene dependent on the MHC Class I kB site or on a longer promoter is transactivated by NF-kB complexes contain- ing p65 or RelB. p100 as well as IkB-a are potent inhibitors of this transcription and p100 sequesters RelB and p65 complexes in the cytoplasm of breast cancer cells. However, although p100 is highly expressed in a number of breast cancer cell lines, MHC Class I antigen expression was observed on all the cell lines we analysed and could be further induced by stimulation with the cytokines IFN-g or TNF-a. Stable transfection of a unresponsive mutated IkB-a Ser 32-36 expression vector showed that TNF-a induced MHC Cl I expression in an NF-kB-dependent way while IFN-g did it independently of any NF-kB activation. [less ▲]

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