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See detailQuantification of Bifidobacterium ssp and Lactobacillus spp in rat fecal samples by real-time PCR
Delroisse, Jean-Marc; Boulvin, Anne-Lise; Parmentier, Isabelle et al

in Archives Internationales de Physiologie et de Biochimie (2005), 191

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See detailTrophoblast Invasion and Placentation: Molecular Mechanisms and Regulation
van den Brule, F.; Berndt, Sarah ULiege; Simon, N. et al

in Chemical Immunology and Allergy (2005), 88

Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection ... [more ▼]

Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed. [less ▲]

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See detailThe Management of Postmenopausal Osteoporosis: A Position Paper of the World Health Origination Collaborating Center on Public Health Aspects of Rheumatic Diseases
Delmas, P. D.; Khaltaev, N.; Arriagada, M. et al

in Journal of Musculoskeletal & Neuronal Interactions (2005), 5(2), 105-9

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See detailRisque d'antériorité ou risque déjà réalisé
Paris, Catherine ULiege

in Bulletin des Assurances = Tijdschrift voor Verzekeringen (2005)

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See detailExpression and purification of the human Tre2 product, a putative Ypt/Rab GTPase activating protein.
Bizimungu, Christelle; Stroobants, Aurore ULiege; Tricot, Catherine et al

in Archives Internationales de Physiologie et de Biochimie (2005), 191

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See detailDermatoses photo-aggravées.
Goffin, Véronique ULiege; Nikkels, Arjen ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2005), 60 Suppl 1

A series of viral and bacterial diseases are photoaggravated. Some autoimmune connective tissue disorders including lupus erythematosus and dermatomyositis are also affected. This category of ... [more ▼]

A series of viral and bacterial diseases are photoaggravated. Some autoimmune connective tissue disorders including lupus erythematosus and dermatomyositis are also affected. This category of photoexacerbated diseases also encompasses some cases of atopic dermatitis, lichen and rosacea. [less ▲]

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See detailApolipoprotein L-1 Promotes Trypanosome Lysis By Forming Pores In Lysosomal Membranes
Perez-Morga, David; Vanhollebeke, Benoit; Paturiaux-Hanocq, Françoise et al

in Science (2005), 309(5733), 469-72

Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a ... [more ▼]

Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a membrane-addressing domain. In lipid bilayer membranes, apolipoprotein L-I formed anion channels. In Trypanosoma brucei, apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed. [less ▲]

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See detailTryptophane-based biphenylsulfonamide matrix metalloproteinase inhibitors as tumor imaging agents
Oltenfreiter, R.; Staelens, L.; Labied, Soraya ULiege et al

in Cancer Biotherapy & Radiopharmaceuticals (2005), 20(6), 639-47

Aim: As a part of our efforts to use small organic matrix metalloproteinase (MMP) inhibitors with improved characteristics for the diagnosis and treatment of different kinds of tumor tissues ... [more ▼]

Aim: As a part of our efforts to use small organic matrix metalloproteinase (MMP) inhibitors with improved characteristics for the diagnosis and treatment of different kinds of tumor tissues, biphenylsulfonamide analogues were synthesized. This study reports on the in vivo biodistribution of iodine-123-labeled biphenylsulfonide and analogues in A549 lung carcinoma inoculated into athymic mice and the evaluation of their suitability as imaging agents using a single photon emission computed tomography (SPECT) camera. Methods: The radioiodinated carboxylic and hydroxamic MMP inhibitors 2-(4′- [123I]iodobiphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionic acid (1′) and 2-(4′-[123I]iodobiphenyl-4- sulfonylamino)-3-(1H-indol-3-yl)-propionamide (2′) were synthesized by electrophilic aromatic substitution of the tributylstannyl derivatives. Planar gamma camera imaging was performed in nu/nu athymic mice bearing an A549 tumor using a Toshiba GCA-9300A/hg SPECT camera in planar mode equipped with a high-resolution, parallel-hole collimator. Results: Radiosynthesis of (1′) and (2′) resulted in radiochemical yields of 60 ± 5% (n ± 3) and 70 ± 5% (n = 6), respectively. Evaluation of tumors induced in athymic mice by the inoculation of non-small cell lung A549 carcinoma cells, showed a tumor uptake of 0.27–0.01 percent injected dose per gram (%ID/g) (3 hours–48 hours p.i.), a tumor-blood ratio of 0.7, a tumor-muscle ratio of 1.6, and a tumor-fat ratio of 0.5 at 24 hours (p.i.) for compound 1′. For compound 2′ a tumor uptake of 0.7–0.04 %ID/g (3 hours–48 hours p.i.), a postinjection tumor-blood ratio of 1.2, a tumor-muscle ratio of 3.2, and a tumor-fat ratio of 2.4 at 48 hours p.i. was observed. SPECT evaluation confirmed the results obtained from biodistribution. Conclusion: In vivo evaluation of these radioiodinated carboxylic and hydroxamic MMP inhibitor tracers revealed that they do not appear suitable as tumor-imaging agents. [less ▲]

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See detailParamètres génétiques et non-génétiques des caractères de croissance du mouton Djallonké au Bénin - Genetics and non-genetics parameters of West African Dward sheep growth traits in Benin
Gbangboche, A. B.; Abiola, F.; Michaux, Charles ULiege et al

in Rencontres autour des Recherches sur les Ruminants (2005), 12

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See detailPlanktonic and whole system metabolism in a nutrient rich estuary (the Scheldt estuary)
Gazeau, Frédéric; Gattuso, Jean-Pierre; Middelburg, Jack J. et al

in Estuaries (2005), 28(6), 868-883

Planktonic gross primary production (GPP), community respiration (CR), and nitrification (NIT) were measured monthly in the Scheldt estuary by the oxygen incubation method in 2003. No significant ... [more ▼]

Planktonic gross primary production (GPP), community respiration (CR), and nitrification (NIT) were measured monthly in the Scheldt estuary by the oxygen incubation method in 2003. No significant evolution of planktonic GPP was observed since the 1990s with high rates in the freshwater area (salinity 0; 97 6 65 mmol C m22 d21) decreasing seaward (22–37 mmol C m22 d21). A significant decrease of NIT was observed with regard to previous investigations although this process still represents up to 20% of total organic matter production in the inner estuary. Planktonic CR was highest in the inner estuary and seemed to be mainly controlled by external organic matter inputs. Planktonic net community production was negative most of the time in the estuary with values ranging from 2300 to 165 mmol C m22 d21. Whole estuary net ecosystem production (NEP) was investigated on an annual scale using the results mentioned above and published benthic metabolic rates. A NEP of 239 6 8 mmol C m22 d21 was estimated, which confirms the strong heterotrophic status of this highly nutrified estuary. NEP rates were computed from June to December 2003 to compare with results derived from the Land-Ocean Interaction in the Coastal Zone budgeting procedure applied to dissolved inorganic phosphorus and carbon (DIP and DIC). DIP budgets failed to provide realistic estimates in the inner estuary where abiotic processes account for more than 50% of the nonconservative DIP flux. DIC budgets predicted a much lower NEP than in situ incubations (2109 6 31 versus 242 6 9 mmol C m22 d21) although, as each approach is associated with several critical assumptions, the source of this discrepancy remains unclear. [less ▲]

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See detailPour apprendre ensemble : tirer parti de l'apprentissage coopératif dans le cadre des cours de langue
Blondin, Christiane ULiege; Crepin, Françoise ULiege; Mattar, Cathérine

in Informations Pédagogiques (2005), 57

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See detailIdentification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells
Grignet-Debrus, Christine ULiege; Noël, Agnès ULiege; Foidart, Jean-Michel ULiege et al

in Cellular and Molecular Biology (2005), 51(1), 37-48

One of the most frequently studied therapeutic strategies in the field of suicide gene therapy is based on the expression by tumor cells of the Herpes simplex virus thymidine kinase gene (HSVtk) followed ... [more ▼]

One of the most frequently studied therapeutic strategies in the field of suicide gene therapy is based on the expression by tumor cells of the Herpes simplex virus thymidine kinase gene (HSVtk) followed by a ganciclovir (GCV) treatment. In order to investigate the potential of other enzyme/prodrug strategies, we studied in vitro and in vivo the ability of the Varicella zoster virus thymidine kinase gene (VZVtk) to act as a suicide gene and to kill non-transduced bystander cells, and compared this activity to that of its HSV counterpart. Four different antiviral compounds were tested as prodrugs. Our comparative study demonstrates the superiority of the HSVtk/GCV system among the different combinations tested and underlines the importance of both the tumor cell type and the prodrug in the success of a prodrug/suicide gene strategy. [less ▲]

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See detailPlusieurs épidémies de fièvre hémorragique due au virus Ebola au Gabon, d'octobre 2001 à avril 2002
Nkoghe Mba, Dieudonne ULiege; Formenty, P; Leroy, E M et al

in Bulletin de la Société de Pathologie Exotique (2005), 98(3), 224-229

Des épidémies de fièvre hémorragique virale à virus Ebola (FHVE) ont été rapportées de 1994 à 1996 dans la province de l’Ogooué Ivindo, une zone forestière située au Nord Est du Gabon. Chaque fois, les ... [more ▼]

Des épidémies de fièvre hémorragique virale à virus Ebola (FHVE) ont été rapportées de 1994 à 1996 dans la province de l’Ogooué Ivindo, une zone forestière située au Nord Est du Gabon. Chaque fois, les grands primates avaient été reconnus comme la source initiale de l’infection humaine. Fin novembre 2001 une nouvelle alerte est venue de cette province qui a rapidement était confirmée comme étant une épidémie de FHVE. La riposte a été organisée par le ministère de la santé publique avec l’aide d’une équipe internationale sous l’égide de l’OMS. Un système de surveillance active a été mis en place dans les trois districts touchés par l’épidémie (Zadié, Ivindo and Mpassa) afin d’organiser la détection des cas et le suivi de leur contacts. Une définition de cas a été adoptée, les cas suspects étaient isolés à l’hôpital, à domicile ou dans des lazarets, et des tests sérologiques étaient réalisés. Ces tests comportaient la détection de l’antigène ou des IgG spécifiques, et la RT-PCR. Un classement des cas était réalisé en fonction des résultats des tests biologiques et des données cliniques et épidémiologiques. Les sujets contacts étaient surveillés durant 21 jours. On a dénombré 65 cas dont 53 décès. Le premier cas humain, un chasseur, était décédé le 28 octobre 2001. L’épidémie s’est propagée grâce une transmission familiale et une contamination nosocomiale. Quatre foyers primaires distincts ont été mis en évidence ainsi qu’un cas isolé situé dans le Sud est du Gabon, à 580 km de l’épicentre, Les décès sont survenus dans un délai de 6 jours. Le dernier décès a été enregistré le 22 mars 2002 et la fin de l’épidémie déclarée le 6 mai 2002. L’épidémie s’est étendue au Congo voisin. Des morts inexpliquées d’animaux avaient été signalées dans les forêts environnantes dès le mois d’août 2001 : des grands primates et des céphalophes. Les prélèvements réalisés sur leurs carcasses confirmaient une épidémie animale concomitante. [less ▲]

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See detailUn moine collectionneur de gravures à l'abbaye du Val-Dieu, Servais Duriau (1701-1775)
Postula, Jean-Louis ULiege

in Bulletin de la Société Royale Le Vieux-Liège (2005), XIV(310), 665-696

Cet article présente une importante collection de gravures, actuellement conservée au Trésor de la cathédrale de Liège, constituée au XVIIIe siècle par un moine de l’abbaye cistercienne du Val-Dieu (Aubel ... [more ▼]

Cet article présente une importante collection de gravures, actuellement conservée au Trésor de la cathédrale de Liège, constituée au XVIIIe siècle par un moine de l’abbaye cistercienne du Val-Dieu (Aubel, belgique), Servais Duriau, et demeurée inédite. Cet ensemble, riche de plus de douze mille pièces présentées dans dix-neuf albums reliés, est ainsi décrit et analysé dans une perspective historique. Nous nous intéressons ensuite à la biographie du moine Duriau et à l’évolution de la collection, depuis le siècle des Lumières jusqu’à nos jours. [less ▲]

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See detailPrimary temporal bone angiosarcoma: a case report.
Scholsem, Martin; Raket, Daniel; Flandroy, Pierre et al

in Journal of neuro-oncology (2005), 75(2), 121-5

We present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a ... [more ▼]

We present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a tender swelling above the mastoid. Cranial imaging studies showed a 7 x 5 x 4 cm hypervascularized mass located in the left middle fossa with lysis of the temporal bone and extension to the subcutis. After the baby was delivered by caesarean section, the patient entered the oncology protocol. Selective embolization of the feeding vessels was followed by gross total surgical resection using a combined supra- and infra-tentorial approach. Pathological findings were those of a poorly differentiated, highly malignant sarcoma with a large epitheloid component and immunohistochemical evidence of endothelial differentiation (CD31, Factor VIII related antigen, CD34), consistent with an angiosarcoma with epitheloid features. No extra-cranial tumor was found after extensive staging. The patient received adjuvant radiotherapy followed by a course of chemotherapy consisting of 6 cycles of paclitaxel. At 15 months follow-up, she developed multiple distant metastasis to a left postauricular lymph node and to the lungs and ribs. The patient was given a second line chemotherapy using doxorubicine and ifosfamide. Despite an initial good response, she died with metastatic disease 26 months after diagnosis. We present a rare case of primary temporal bone angiosarcoma and report our experience with a multimode therapeutic approach combining surgery, radiotherapy and chemotherapy. [less ▲]

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See detailRiver dredging, channel dynamics and bedload transport in an incised meandering river (the River Semois, Belgium).
Gob, F.; Houbrechts, Geoffrey ULiege; Hiver, J. M. et al

in River Research & Applications (2005), 21(7), 791-804

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See detailDesign, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials.
Salvagnini, Claudio; Michaux, Catherine; Remiche, Julie ULiege et al

in Organic & Biomolecular Chemistry (2005), 3(23), 4209-20

Piperazinyl-amide derivatives of N-alpha-(3-trifluoromethyl-benzenesulfonyl)-L-arginine (1) were synthesized as graftable thrombin inhibitors. The possible disturbance of biological activity due to a ... [more ▼]

Piperazinyl-amide derivatives of N-alpha-(3-trifluoromethyl-benzenesulfonyl)-L-arginine (1) were synthesized as graftable thrombin inhibitors. The possible disturbance of biological activity due to a variable spacer-arm fixed on the N-4 piperazinyl position was evaluated in vitro, against human alpha-thrombin, and in blood coagulation assay. Molecular modelling (in silico analysis) and X-ray diffraction studies of thrombin-inhibitor complexes were also performed. The fixation of bioactive molecules on poly(butylene terephthalate) (PBT) and poly(ethylene terephthalate) (PET) membranes was performed by wet chemistry treatment and evaluated by XPS analysis. Surface grafting of inhibitor 1d improved the membrane hemocompatibility by reducing blood clot formation on the modified surface. [less ▲]

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See detailInsuffisance cardiaque et diabete
ANCION, A.; Lancellotti, Patrizio ULiege; Pierard, Luc ULiege

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 536-40

Diabetic patients frequently develop heart failure and have a guarded prognosis because of the combination of diabetic cardiomyopathy, hypertension and ischaemic heart disease. The lack of patient ... [more ▼]

Diabetic patients frequently develop heart failure and have a guarded prognosis because of the combination of diabetic cardiomyopathy, hypertension and ischaemic heart disease. The lack of patient awareness of the association between diabetes and cardiovascular disease contributes to the risk of heart failure in the diabetic population. Therefore, physicians should consider the risk of comorbidities and use appropriate screening tests to achieve early identification and initiate preventive strategies. There is evidence suggesting that adequate glycaemic control may improve cardiac metabolism and myocardial function in diabetics with heart failure. Improvement in cardiac function engendered by neurohumoral inhibition is associated with a decrease in mortality that is at least as great in the diabetic patients with heart failure as it is in the non diabetic patients. However, several therapeutic interventions have not yet been specifically validated in diabetic subjects. Thus, physicians should be encouraged to use therapies tested in the diabetic population, such as B-blockers and ACE inhibitors. Diabetic patients would benefit from more aggressive preventive programs aimed at reducing the incidence of cardiovascular morbidity and mortality. [less ▲]

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See detailVariation of plasma parameters and nitrogen metabolism in finishing Belgian blue double-muscled cull females.
Cabaraux, Jean-François ULiege; Dufrasne, Isabelle ULiege; Istasse, Louis ULiege et al

in Journal of Animal Physiology & Animal Nutrition (2005), 89(1-2), 55-62

The changes over time in plasma parameters and nitrogen metabolism were studied in finishing Belgian Blue double-muscled females offered a maize silage based diet. When compared with literature data ... [more ▼]

The changes over time in plasma parameters and nitrogen metabolism were studied in finishing Belgian Blue double-muscled females offered a maize silage based diet. When compared with literature data, plasma glucose along with triglycerides concentrations was low while non-esterifled fatty acids were high and rich in polyunsaturated forms. The concentrations in thyroid hormones, insulin-like growth factor 1 and insulin were also low and plasma insulin decreased with time. Growth hormone concentration, by contrast, increased with time. On average, the females retained 44 g nitrogen per day from an intake of 210 g but the efficiency of retention decreased with time. The fractional rates of accretion and synthesis of muscle protein were also affected by time. The dry matter content in muscle biopsies was close to 22% and increased with the finishing, as did the diameter of the tailhead adipocytes. [less ▲]

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See detailDendritic flux penetration in Pb films with a periodic array of antidots
Menghini, M.; Wijngaarden, R. J.; Silhanek, Alejandro ULiege et al

in Physical Review. B : Condensed Matter (2005), 71(10),

We explore the flux-jump regime in type-II Pb thin films with a periodic array of antidots by means of magneto-optical measurements. A direct visualization of the magnetic flux distribution allows us to ... [more ▼]

We explore the flux-jump regime in type-II Pb thin films with a periodic array of antidots by means of magneto-optical measurements. A direct visualization of the magnetic flux distribution allows us to identify a rich morphology of flux penetration patterns. We determine the phase boundary H-*(T) between dendritic penetration at low temperatures and a smooth flux invasion at high temperatures and fields. For the whole range of fields and temperatures studied, guided vortex motion along the principal axes of the square pinning array is clearly observed. In particular, the branching process of the dendrite expansion is fully governed by the underlying pinning topology. A comparative study between macroscopic techniques and direct local visualization sheds light onto the puzzling T- and H-independent magnetic response observed at low temperatures and fields. Finally, we find that the distribution of avalanche sizes at low temperatures can be described by a power law with exponent tau similar to 0.9(1). [less ▲]

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See detailKinetics of engraftment following allogeneic hematopoietic cell transplantation with reduced-intensity or nonmyeloablative conditioning.
Baron, Frédéric ULiege; Little, Marie-Terese; Storb, Rainer

in Blood Reviews (2005), 19(3), 153-64

Nonmyeloablative or reduced-intensity conditioning regimens have been used to condition elderly or ill patients with hematological malignancies for allogeneic hematopoietic cell transplantation (HCT ... [more ▼]

Nonmyeloablative or reduced-intensity conditioning regimens have been used to condition elderly or ill patients with hematological malignancies for allogeneic hematopoietic cell transplantation (HCT). Initial mixed donor/host chimerism (i.e. the coexistence of hematopoietic cells of host and donor origin) has been observed in most patients after such transplants. Here, we describe both factors affecting engraftment kinetics in patients given a nonmyeloablative or a reduced-intensity conditioning, and associations between peripheral blood cell subset chimerism levels and HCT outcomes. [less ▲]

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See detailAstronomes célèbres et astronomes moins connus ... (6) John Flamsteed
Biémont, Emile ULiege

in Galactée (2005), 46

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See detailDevelopment of biofilters to treat the pesticides wastes from spraying applications.
Pigeon, O.; de Vleeschouwer, C.; Cors, F. et al

in Communications in Agricultural and Applied Biological Sciences (2005), 70(4),

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See detailLes unités de division du temps
Biémont, Emile ULiege

in Bulletin de la Société Royale des Sciences de Liège (2005), 74(4), 243-269

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See detailBeyond the Mediterranean peninsulas: evidence of central European glacial refugia for a temperate forest mammal species, the bank vole (Clethrionomys glareolus).
Deffontaine Deurbroeck, Valérie ULiege; Libois, Roland ULiege; Kotlík, Petr et al

in Molecular Ecology (2005), 14(6), 1727-1739

This study details the phylogeographic pattern of the bank vole, Clethrionomys glareolus, a European rodent species strongly associated with forest habitat. We used sequences of 1011 base pairs of the ... [more ▼]

This study details the phylogeographic pattern of the bank vole, Clethrionomys glareolus, a European rodent species strongly associated with forest habitat. We used sequences of 1011 base pairs of the mitochondrial DNA cytochrome b gene from 207 bank voles collected in 62 localities spread throughout its distribution area. Our results reveal the presence of three Mediterranean (Spanish, Italian and Balkan) and three continental (western, eastern and 'Ural') phylogroups. The endemic Mediterranean phylogroups did not contribute to the postglacial recolonization of much of the Palaearctic range of species. Instead, the major part of this region was apparently recolonized by bank voles that survived in glacial refugia in central Europe. Moreover, our phylogeographic analyses also reveal differentiated populations of bank voles in the Ural mountains and elsewhere, which carry the mitochondrial DNA of another related vole species, the ruddy vole (Clethrionomys rutilus). In conclusion, this study demonstrates a complex phylogeographic history for a forest species in Europe which is sufficiently adaptable that, facing climate change, survives in relict southern and northern habitats. The high level of genetic diversity characterizing vole populations from parts of central Europe also highlights the importance of such regions as a source of intraspecific genetic biodiversity. [less ▲]

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See detailLa IIIéme République démocratique du Congo : Nouveau régionalisme
Kabamba, Bob ULiege; Verjans, Pierre ULiege

in Fédéralisme - Régionalisme (2005), volume 5(2004-2005),

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See detailSelection of antagonists of postharvest apple parasites: penicillium expansum and botrytis cinerea
Achbani, E. H.; Mounir, R.; El Jaafari, S. et al

in Communications in Agricultural and Applied Biological Sciences (2005), 70(3), 143-149

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See detailUne Constitution pour une troisième République équilibrée
Banneux, Nicolas ULiege; Bossuyt, Marc; Boshab, Evariste et al

in Fédéralisme - Régionalisme (2005), volume 5(2004-2005), 81-102

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See detailDistribution of leucocyte subsets in the canine respiratory tract
Peeters, Dominique ULiege; Day, M. J.; Farnir, Frédéric ULiege et al

in Journal of Comparative Pathology (2005), 132(4), 261-272

Histochemistry and immunohistochemistry were used to characterize leucocyte subsets in the respiratory tract of 15 outbred dogs (five aged <6 months and 10 aged >1 year) that had no evidence of ... [more ▼]

Histochemistry and immunohistochemistry were used to characterize leucocyte subsets in the respiratory tract of 15 outbred dogs (five aged <6 months and 10 aged >1 year) that had no evidence of respiratory disease. No organized nose- or bronchus-associated lymphoid tissue was observed in any of the sections examined. IgA(+) plasma cells predominated in nasal mucosa and in all parts of the bronchial tree, with fewer IgG(+) and IgM(+) plasma cells. The numbers of IgA(+) and IgM(+) cells were significantly greater in the nasal mucosa than in any other part of the respiratory mucosa. There were significantly fewer IgA(+), IgG(+) and IgM(+) cells in all parts of the respiratory tract in the puppies than in the adults. The number and distribution of mast cells and cells expressing MHC class II, L1 or CD1c were recorded. Mast cells were mainly found in the subepithelial lamina propria of nasal and bronchial mucosa and in the alveolar interstitium, and cells expressing IgE had a similar distribution. Mast cells were also present within muscle layers of the bronchial tree. The numbers of mast cells and MHC class II(+) cells were significantly greater in the nasal mucosa than in any other part of the respiratory mucosa. In the nose, carina and primary and secondary bronchus, there were significantly more mast cells and MHC class II(+) cells in puppies than in adult dogs, whereas the numbers of L1(+) cells and CD1c(+) cells in most sites were significantly greater in older dogs. There were significantly more CD3(+) and CD8(+) cells in the nasal mucosa than in any part of the bronchial mucosa. In most parts of the respiratory mucosa, CD4(+), CD8(+) and TCR alphabeta(+) cells were present in significantly greater numbers in adults than in puppies. All parts of the respiratory tract had similar numbers of mucosal CD4(+) and CD8(+) T lymphocytes. TCR gammadelta(+) cells were absent or sparse in all samples. These data, obtained from dogs without respiratory disease, will enable comparisons to be made with dogs suffering from infectious or inflammatory nasal, bronchial and pulmonary diseases. [less ▲]

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See detailGiuliano Gasparri, Il cartesianismo di René Fedé
Dubouclez, Olivier ULiege

in Bulletin cartésien (2005)

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See detailImpact implantation of a transmitter on Sarpa salpa behaviour: study with a computerized video tracking system
Jadot, Catherine; Donnay, Annick ULiege; Ylieff, Marc ULiege et al

in Journal of Fish Biology (2005), 67(2), 589-595

Two transmitter masses (2 and 6% of the fish's mass) were selected to examine the interference of tags with the behaviour of Sarpa salpa using a computerized video tracking system based on digital imaging ... [more ▼]

Two transmitter masses (2 and 6% of the fish's mass) were selected to examine the interference of tags with the behaviour of Sarpa salpa using a computerized video tracking system based on digital imaging techniques. The study demonstrated that light transmitters had no effect on the behavioural variables studied, and a substantial bias in behaviour is introduced if heavier (6%) tags are used. (c) 2005 The Fisheries Society of the British Isles. [less ▲]

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See detailJean de Silhon, De la certitude des connaissances humaines
Dubouclez, Olivier ULiege

in Bulletin cartésien (2005)

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See detailComment j'explore....une pathologie d'aspect microscopique cutané apparemment sain.
Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2005), 60(2), 117-20

Some dermatologic disorders named "Invisible dermatoses" are defined by obvious clinical signs while histologic alterations remain discrete. This situation may lead to clinico-pathological discrepancies ... [more ▼]

Some dermatologic disorders named "Invisible dermatoses" are defined by obvious clinical signs while histologic alterations remain discrete. This situation may lead to clinico-pathological discrepancies impeding the establishment of a diagnosis. In other cases, the skin looks clinically normal but the histological examination allows to disclose some systemic diseases. Systematic analysis of the skin biopsy complemented by histochemical and immunohistochemical techniques may help reach the diagnosis. [less ▲]

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See detailDistribution of leucocyte subsets in bronchial mucosa from dogs with eosinophilic bronchopneumopathy
Peeters, Dominique ULiege; Day, M. J.; Clercx, Cécile ULiege

in Journal of Comparative Pathology (2005), 133(2-3, Aug-Oct), 128-135

Immunohistochemistry was used to characterize the distribution of leucocyte subsets in the bronchial mucosa of 11 dogs with idiopathic eosinophilic bronchopneumopathy (EBP). Formalin-fixed tissues from ... [more ▼]

Immunohistochemistry was used to characterize the distribution of leucocyte subsets in the bronchial mucosa of 11 dogs with idiopathic eosinophilic bronchopneumopathy (EBP). Formalin-fixed tissues from all dogs were included in the study, but frozen tissue from only one dog was available. MHC class II(+) cells were found in moderate numbers in the lamina propria (LP). These cells were morphologically either dendritic-like cells or macrophages, but many macrophages did not express MHC class II. Such molecules were expressed by occasional fibroblasts. L1(+) cells, which formed a relatively small component of the LP inflammatory infiltrate, were morphologically either macrophages or polymorphonuclear cells (probably eosinophils). IgA(+) plasma cells were found in varying numbers in the LP, mostly in association with glandular tissue. IgG(+) plasma cells were less common, and IgM(+) plasma cells were present in low numbers. Many CD3(+) cells were present in the LP. In the single case from which frozen tissue was available, most of the lymphocytes were labelled with CD4 marker, while smaller numbers were CD8(+) T cells. Most of the lymphocytes in this case were positively labelled with T-cell receptor (TCR)-alphabeta marker. TCR-gammadelta(+) cells, although less common, were present in significant numbers throughout the LP. CDlc(+) dendritic cells were numerous in the epithelium and in the LP, immediately beneath the basement membrane. These findings, which were similar to those described in human asthma, are suggestive of a Th2 dominant immune response in canine EBP. As in human asthma, this provides a possible basis for new forms of treatment in canine EBP. [less ▲]

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See detailRegulation of the mammalian heart function by nitric oxide.
MASSION, Paul ULiege; Pelat, Michel; Belge, C. et al

in Comparative Biochemistry & Physiology Part A : Molecular & Integrative Physiology (2005), 142(2), 144-50

The mammalian heart expresses all three isoforms of nitric oxide synthases (NOS) in diverse cell types of the myocardium. Despite their apparent promiscuity, the NOS isoforms support specific signaling ... [more ▼]

The mammalian heart expresses all three isoforms of nitric oxide synthases (NOS) in diverse cell types of the myocardium. Despite their apparent promiscuity, the NOS isoforms support specific signaling because of their subcellular compartmentation with colocalized effectors and limited diffusibility of NO in muscle cells. eNOS and nNOS sustain normal EC coupling and contribute to the early and late phases of the Frank-Starling mechanism of the heart. They also attenuate the beta1-/beta2-adrenergic increase in inotropy and chronotropy, and reinforce the pre- and post-synaptic vagal control of cardiac contraction. By doing so, the NOS protect the heart against excessive stimulation by catecholamines, just as an "endogenous beta-blocker". In the ischemic and failing myocardium, induced iNOS further reinforces this effect, as does eNOS coupled to overexpressed beta3-adrenoceptors. nNOS expression also increases in the aging and infarcted heart, but its role (compensatory or deleterious) is less clear. In addition to their direct regulation of contractility, the NOS modulate oxygen consumption, substrate utilization, sensitivity to apoptosis, hypertrophy and regenerative potential, all of which illustrate the pleiotropic effects of this radical on the cardiac cell biology. [less ▲]

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See detailIn situ aortic allograft insertion to repair a primary aortoesophageal fistula due to thoracic aortic aneurysm
Pirard, Laurence ULiege; Creemers, Etienne ULiege; Van Damme, Hendrik ULiege et al

in Vascular Surgery (2005), 42

Aortoesophageal fistula due to thoracic aortic aneurysm is an uncommon cause of gastrointestinal bleeding and has an extremely poor prognosis. In the English literature, we found only 27 successfully ... [more ▼]

Aortoesophageal fistula due to thoracic aortic aneurysm is an uncommon cause of gastrointestinal bleeding and has an extremely poor prognosis. In the English literature, we found only 27 successfully managed cases of primary aortoesophageal fistula due to thoracic aortic aneurysm. We present a case of 74-year-old man who experienced the erosion of a thoracoabdominal aortic aneurysm into the esophagus. We successfully performed resection and replacement of the thoracoabdominal aorta with a cryopreserved allograft and total thoracic esophagectomy. A few months later, the esophagus was reconstructed with orthotopic colonic interposition. The patient recovered well and resumed a normal life (12 months’ follow-up). [less ▲]

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See detailHuman cognition during REM sleep and the activity profile within frontal and parietal cortices: a reappraisal of functional neuroimaging data
Maquet, Pierre ULiege; Ruby, P.; Maudoux, Audrey ULiege et al

in Progress in Brain Research (2005), 150(Boundaries of Consciousness: Neurobiology and Neuropathology), 219-227

In this chapter, we aimed at further characterizing the functional neuroanatomy of the human rapid eye movement (REM) sleep at the population level. We carried out a meta-analysis of a large dataset of ... [more ▼]

In this chapter, we aimed at further characterizing the functional neuroanatomy of the human rapid eye movement (REM) sleep at the population level. We carried out a meta-analysis of a large dataset of positron emission tomography (PET) scans acquired during wakefulness, slow wave sleep and REM sleep, and focused especially on the brain areas in which the activity diminishes during REM sleep. Results show that quiescent regions are confined to the inferior and middle frontal cortex and to the inferior parietal lobule. Providing a plausible explanation for some of the features of dream reports, these findings may help in refining the concepts, which try to account for human cognition during REM sleep. In particular, we discuss the significance of these results to explain the alteration in executive processes, episodic memory retrieval and self representation during REM sleep dreaming as well as the incorporation of external stimuli into the dream narrative. [less ▲]

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See detailPassage sur le fonds d'autrui: variations sur un même thème
Boufflette, Sophie ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2005)

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See detailLambinonia, a new genus for Melanconium strigulae, a lichenicolous hyphomycete on foliicolous species of Strigula
Sérusiaux, Emmanuel ULiege; Diederich, P.

in Lichenologist (2005), 37(Part 6), 499-506

The new genus Lambinonia Serus.

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See detailContribution a l'etude des effets perturbateurs endocriniens des polluants environnementaux
Charlier, Corinne ULiege

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2005), 160(5-6), 301-10

There is an increasing scientific concern that organochlorine compounds, recognized as environmental act through their estrogenic or anti-estrogenic properties. Many endocrine diseases can be concerned by ... [more ▼]

There is an increasing scientific concern that organochlorine compounds, recognized as environmental act through their estrogenic or anti-estrogenic properties. Many endocrine diseases can be concerned by the pathogenic role on environmental residues in their promotion. The carcinogenic potential of environmental xenoestrogens on breast cancer is a matter of controversy. In Europe, despite their prohibition since the 70's, residues persist in soil and rivers, resulting in a widespread contamination of the general population. Our results suggest that environmental exposure to p,p' -DDE, HCB or PCBs may contribute to multifactorial pathogenesis of breast cancer. Male infertility is also a matter of concern. Our data suggest that male infertility can be associated with exposure of the mothers to p,p'-DDE, and that deleterious effects are probably restricted to intra-uterine life. Early or precocious puberty in children adopted from developing countries where organochlorines are still used is frequently reported. A possible relationship with exposure to DDT is suggested. There are two possible pathways to account for precocious puberty following chronic exposure to estrogenic related compounds: weak stimulation of estrogen sensitive tissues or removal in Belgium of the suppressing effects of estrogens on gonadotrophins, suppressing effect that was due to exposure in the country of origin. [less ▲]

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See detailA comparative inventory of metal transporters in the green alga Chlamydomonas reinhardtii and the red alga Cyanidioschizon merolae
Hanikenne, Marc ULiege; Krämer, Ute; Demoulin, Vincent ULiege et al

in Plant Physiology (2005), 137(2), 428-446

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See detailCombined micro-Fourier transform infrared (FTIR) spectroscopy and micro-Raman spectroscopy of Proterozoic acritarchs: A new approach to Palaeobiology
Marshall, C. P.; Javaux, Emmanuelle ULiege; Knoll, A. H. et al

in Precambrian Research (2005), 138(3-4), 208-224

Micro-scale analytical techniques permit correlation of chemistry with morphology of individual Proterozoic acritarchs (organic-walled microfossils), and thus provide new approaches for elucidating their ... [more ▼]

Micro-scale analytical techniques permit correlation of chemistry with morphology of individual Proterozoic acritarchs (organic-walled microfossils), and thus provide new approaches for elucidating their biological affinities. A combination of micro-Fourier transform infrared (FTIR) spectroscopy and laser micro-Raman spectroscopy was used to investigate the organic structure and composition of individual acritarchs. Well preserved Neoproterozoic acritarchs from the Tanana Formation, Australia (ca. 590-565 Ma), and Mesoproterozoic acritarchs from the Roper Group (1.5-1.4 Ga), Australia, and Ruyang Group, China (1.4-1.3 Ga, age poorly resolved but certainly > 1000 Ma and < 1625 Ma) have thermal maturities that range from immature to oil window. FTIR spectra of Tanarium conoideum from the Tanana Formation contain intense aliphatic C-H stretching bands in the 2900 cm(-1) region relative to the C=C aromatic ring stretching band at 1600 cm(-1). This FTIR spectrum is consistent with the FTIR spectra obtained from algaenans isolated from extant chlorophyte and eustigmatophyte microalgae. FTIR spectra of Leiosphaeridia sp. from the Tanana Formation contain a less intense aliphatic C-H stretching band relative to the C=C aromatic ring stretching band. By comparison, the spectra acquired from the Mesoproterozoic acritarchs were dominated by C=C aromatic ring stretching bands at 1600 cm(-1) relative to moderate-weak CH3 terminal groups (1345 cm(-1)), C-H aliphatic stretching (3000-2700 cm(-1)), and C=O (1710 cm-1), although some differences in biopolymer composition occurred between species. Curve-fitting of the aliphatic C-H, stretching region provides greater insight into the aliphatic structures of the acritarchs. The CH2/CH3 intensity ratio can be used to assess the relative chain length and degree of branching. Organic material in the Tanarium conoideum consists of straight long chain hydrocarbons, while the other acritarchs contain hydrocarbons consisting of short chains that are highly branched. In this study it was found that Raman spectroscopy does not provide additional information about biopolymer composition of Proterozoic acritarchs, but rather offers complementary data regarding the aromaticity and degree of saturation of the macromolecular structure of acritarch cysts. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailCurrent Concepts in the Therapeutic Management of Osteoarthritis with Glucosamine
Reginster, Jean-Yves ULiege; Bruyère, Olivier ULiege; Fraikin, Genevieve et al

in Bulletin / Hospital for joint diseases (2005), 63(1-2), 31-36

Over the last 10 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is ... [more ▼]

Over the last 10 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, is able to significantly reduce the symptoms of osteoarthritis in the lower limbs and spine. This effect is usually seen with a minimal time for the onset of significant action - around 2 weeks. A similar dose of glucosamine sulfate has also been shown, in two independent studies, to prevent the joint space narrowing observed at the femorotibial compartment in patients with mild to moderate knee osteoarthritis. This effect, which is not affected by the radiographic technique used for the assessment of joint space width, also translated into a 50% reduction in the incidence of osteoarthritis-related surgery of the lower limbs during a 5-year period following the withdrawal of the treatment. There is a high degree of consistency in the literature showing that when glucosamine sulfate is used for the treatment of osteoarthritis, an efficacious response with minimum side effects can be expected. Since some discrepancies have been described between the results of studies performed with a patent-protected formulation of glucosamine sulfate distributed as a drug and those having used glucosamine preparations purchased from global suppliers, packaged, and sold over-the-counter as nutritional supplements (not regulated as drugs and with some potential issues concerning the reliability of their content), caution should be used when extrapolating conclusive results obtained with prescription drugs to over-the-counter or food supplements. [less ▲]

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See detailDifficultés dans l'utilisation d'instruments de pilotage pour la définition des politiques de sécurité locales-Le cas du moniteur de sécurité en Belgique
Lemaître, André ULiege; Ponsaers, Paul

in Revue de la Faculté de Droit de l'Université de Liège (2005), 2005/1

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See detailAcute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides
Vanderperren, Bénédicte; Rizzo, Michela; Angenot, Luc ULiege et al

in Annals of Pharmacotherapy (2005), 39(7-8, JUL-AUG), 1353-1357

OBJECTIVE: To report a case of chronic ingestion of very large amounts of senna fruits as an herbal tea, possibly leading to severe hepatotoxicity. CASE SUMMARY: A 52-year-old woman who had ingested, for ... [more ▼]

OBJECTIVE: To report a case of chronic ingestion of very large amounts of senna fruits as an herbal tea, possibly leading to severe hepatotoxicity. CASE SUMMARY: A 52-year-old woman who had ingested, for > 3 years, one liter of an herbal tea each day made from a bag containing 70 g of dry senna fruits, developed acute hepatic failure and renal impairment requiring intensive care therapy. The severity of the hepatic failure was reflected by the increase in prothrombin time (international normalized ratio > 7) and the development of encephalopathy. Liver transplantation was discussed, but the patient ultimately recovered with supportive therapy. Renal impairment was consistent with proximal tubular acidosis, also with marked polyuria refractory to vasopressin administration. Suprisingly, large amounts of cadmium were transiently recovered in the urine. DISCUSSION: Cassia acutifolia and angustifolia plants are widely used as laxatives. Their chronic abuse may be associated with serious manifestations, including fluid and electrolyte loss, with chronic diarrhea. Severe hepatotoxicity is unusual, but could be explained by the exposure of the liver to unusual amounts of toxic metabolites of anthraquinone glycosides (sennosides). An objective causality assessment suggests that hepatotoxicity was possibly related to senna laxative abuse. Regarding nephrotoxicity, there are no available human data on sennosides, while experimental models suggest that anthraquinone derivatives may also accumulate in the kidneys. The finding of high urinary concentrations of cadmium would suggest contamination of the herbal tea by metals, but this hypothesis could not be verified. CONCLUSIONS: Ingestion of large doses of senna laxatives may expose people to the risk of hepatotoxicity. [less ▲]

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See detailPhosphorylation Of Histone Deacetylase 7 By Protein Kinase D Mediates T Cell Receptor-Induced Nur77 Expression And Apoptosis
Dequiedt, Franck ULiege; Van Lint, J.; Lecomte, E. et al

in Journal of Experimental Medicine (2005), 201(5),

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See detailBelCoBack. Une étude prospective sur les facteurs étiologiques et pronostiques des maux de dos liés à la profession
Somville, Pierre-René ULiege; Van Nieuwenhuyse, A.; Moens, G. et al

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2005), 42(4), 159-164

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See detailUltrasonographic and radiographic diagnosis of patellar fragmentation secondary to bilateral medial patellar ligament desmotomy in a Warmblood gelding
Labens, R.; Busoni, Valeria ULiege; Peters, F. et al

in Equine Veterinary Education (2005), 17(4), 201-206

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See detailRepeated cadmium nebulizations induce pulmonary MMP-2 and MMP-9 production and emphysema in rats.
Kirschvink, Nathalie; Vincke, Gregoire; Fievez, Laurence ULiege et al

in Toxicology (2005), 211(1-2), 36-48

This study describes induction of pulmonary inflammation, production of matrix metalloprotease of type 2 (MMP-2) and type 9 (MMP-9), and emphysema in cadmium (Cd)-exposed rats. Sprague-Dawley rats were ... [more ▼]

This study describes induction of pulmonary inflammation, production of matrix metalloprotease of type 2 (MMP-2) and type 9 (MMP-9), and emphysema in cadmium (Cd)-exposed rats. Sprague-Dawley rats were randomly distributed into two groups: one placebo-exposed group undergoing saline (NaCl 0.9%) inhalation (n=30) and one Cd-exposed group undergoing cadmium (CdCl(2) 0.1%) inhalation (n=30). The animals of the placebo- and Cd-exposed groups were divided in five subgroups (n=6). Subgroups underwent either a single exposure of 1h or repeated exposures three times weekly for 1h during 3 weeks (3W), 5 weeks (5W), 5 weeks followed by 2 weeks without exposure (5W+2) or 5 weeks followed by 4 weeks without exposure (5W+4). Each animal underwent determination of enhanced pause (Penh) as index of airflow limitation prior to the first exposure as well as before sacrifice. The animals were sacrificed the day after their last exposure. The left lung was fixed for histomorphometric analysis (determination of median interwall distance (MIWD)), whilst bronchoalveolar lavage fluid (BALF) was collected from the right lung. BALF was analyzed cytologically, and MMP-2 and MMP-9 levels were determined by gelatine zymography. Twelve rats previously instilled with pancreatic elastase were used as positive emphysema controls and underwent the same investigations. Cd-exposure induced a significant increase of BALF macrophages, neutrophils and MMP-9 up to 5W+4, whereas MMP-2 gelatinolytic activity returned to baseline levels within 5W. MIWD was significantly increased in all repeatedly Cd-exposed groups and elastase-treated rats. Penh was increased in Cd-exposed rats after a single exposure and after 3W. MMP gelatinolytic activity was significantly correlated with macrophages, neutrophils and Penh. In repeatedly exposed rats, MIWD was positively and significantly correlated with MMP gelatinolytic activity, suggesting that increased MMP-2 and MMP-9 production favours the development of emphysema. [less ▲]

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See detailLes affections cardio-respiratoires les plus fréquentes chez le cheval âgé
Van Galen, Gaby ULiege; Amory, Hélène ULiege

in Nouveau Praticien Vétérinaire Equine (2005)

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See detailPhylogeny and systematics of the lichen family Gomphillaceae (Ostropales) inferred from cladistic analysis of phenotype data
Lücking, Robert; Sérusiaux, Emmanuël ULiege; Vezda, Antonin

in Lichenologist (2005), 37

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See detailPrescription de l'action publique : le droit transitoire de l'article 24 TPCPP à l'épreuve de la Cour d'arbitrage
Monville, Pierre ULiege

in Revue de Droit Pénal et de Criminologie (2005)

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See detailLa présentation dramatique du dialogue dans les contes de Voltaire
Tilkin, Françoise ULiege

in Studies on Voltaire and the Eighteenth Century (2005), (7), 251-259

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See detailRequiem pour Marie de Médicis ­ Gilles Hayne (1590­1650)
Corswarem, Emilie ULiege

in Art&Fact (2005), 24

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See detailBovine pepsinogen and Prochymosin : Current knowledge, applications and outlines in the management of gastrointestinal worms
Sidikou, I. D.; Remy, B.; Hornick, Jean-Luc ULiege et al

in Annales de Médecine Vétérinaire (2005), 149(4), 213-228

The characterization of the gastric aspartic proteases and the understanding of their mechanisms of activation led to several applications in many domains as the use of chymosin in cheese industries and ... [more ▼]

The characterization of the gastric aspartic proteases and the understanding of their mechanisms of activation led to several applications in many domains as the use of chymosin in cheese industries and the diagnostic of gastric diseases in humans and animals. Particularly, in cattle, the indirect measurement of pepsinogen activity is largely used for the diagnosis of ostertagiosis. Today, the gastric strongyloses are responsible for serious problems of management or the emergence of parasites resistence towards antihelminthics, and no immediate solution is available. Nevertheless, several tracks are proposed such as a more rational use of antihelminthics by the study of blood pepsinogen. This approach held our attention. The present review describes bovine pepsinogen and prochymosin, with an accent on the zymogen structure, their mechanisms of activation and the methods of blood levels measurement. The manuscript will end on the importance of the problems raised by gastric worms, and on the interest of the measurement of blood pepsinogen in the management of these diseases in cattle. [less ▲]

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See detailMatrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice
Bracke, K.; Cataldo, Didier ULiege; Maes, T. et al

in International Archives of Allergy & Immunology (2005), 138(2), 169-179

An imbalance between proteinases and their inhibitors is believed to play an essential role in the development of chronic obstructive pulmonary disease ( COPD) and pulmonary emphysema. COPD is mainly ... [more ▼]

An imbalance between proteinases and their inhibitors is believed to play an essential role in the development of chronic obstructive pulmonary disease ( COPD) and pulmonary emphysema. COPD is mainly caused by cigarette smoking, and is characterized by an increase in inflammatory cells in small airways and lung parenchyma. We examined the mRNA expression of several proteinases in lungs of mice exposed to cigarette smoke or control air. After 1, 3 and 6 months' smoke exposure there was a significant increase of matrix metalloproteinase (MMP)-12 and Cathepsin D mRNA, compared to air-exposed mice. To determine the cellular origin of MMP-12 and Cathepsin D, we isolated dendritic cells (DCs) and macrophages from the lungs of mice. There was an increase in MMP-12 mRNA after smoke exposure in both macrophage and DC populations, whereas Cathepsin D was predominantly expressed in macrophages. Immunohistochemistry clearly revealed the expression of Cathepsin D protein in alveolar macrophages of cigarette smoke-exposed mice, in contrast to air-exposed littermates. Western blots on lung tissue demonstrated an increase of MMP-12 protein in cigarette smoke- exposed animals. These results indicate that cigarette smoke increases the expression of MMP-12 and Cathepsin D in the lungs of mice, and that not only macrophages but also DCs produce MMP-12. Copyright (C) 2005 S. Karger AG, Basel. [less ▲]

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See detailDeepening a precautionary european policy
Deblonde, M.; du Jardin, Patrick ULiege

in Journal of Agricultural & Environmental Ethics (2005), 18

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See detailThe therapeutic effects of alfacalcidol on bone strength, muscle metabolism and prevention of falls and fractures.
Schacht, E.; Richy, F.; Reginster, Jean-Yves ULiege

in Journal of Musculoskeletal & Neuronal Interactions (2005), 5(3), 273-84

Established osteoporosis in older patients of both sexes is characterized by decoupled bone remodelling induced by sex hormone deficits and by somatopause, but also by lack of vitamin D and reduced ... [more ▼]

Established osteoporosis in older patients of both sexes is characterized by decoupled bone remodelling induced by sex hormone deficits and by somatopause, but also by lack of vitamin D and reduced synthesis of the D-Hormone (calcitriol; 1.25 (OH)2D) in the kidneys and bone, as well as from lack of receptors and/or receptor affinity for D-Hormone in the target organs. Parallel to the decreased bone strength a loss of muscle power occurs, together with an increase in balance disorders and an increasing risk of "intrinsic", nonsyncopal locomotoric falls. In alfacalcidol therapy, D-Hormone is provided to the body in circumvention of its own regulation, by means of which higher hormone concentrations can be achieved in the target tissues than by administration of plain vitamin D. In vitro and in vivo experiments have provided growing evidence that D-Hormone analogs tend to normalize PTH, lead to an increase in the number and activity of osteoblasts, reduce the activity of osteoclasts, and might thus normalize the "high bone turnover" in elderly osteoporotic patients ("supercoupling"). In addition, it has been shown that D-Hormone analogs are able to increase muscle power and walking distance in elderly D-Hormone deficient patients. Besides the known effect on the vertebral fracture rate, new clinical data confirm that D-Hormone analogs might reduce peripheral fractures by reducing falls. The expanded understanding of the pathogenesis of glucocorticoid- induced osteoporosis with its disturbed calcium homeostasis and the pharmacological effects of alfacalcidol, which counteract such iatrogenic bone loss, contribute to the understanding of its clinical efficacy in this most frequent form of secondary osteoporosis. Due to its recently discovered immunomodulating properties, alfacalcidol might find a slot in the management of bone loss caused by chronic inflammatory diseases or by organ transplantations. Alfacalcidol has multifactorial effects, among which the best known are its anti-bone loss and anti-fracture efficacies in postmenopausal osteoporosis. This demonstrated efficacy is related to its involvement in bone remodelling, leading to an improved bone strength. Its mode of action on muscle power, which reduces falls, is unique, differentiating this form of therapy from all other anti-osteoporotic drugs, none having demonstrated any influence on falls. [less ▲]

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See detailChronique de jurisprudence de droit bancaire et financier européen
Partsch, Philippe-Emmanuel ULiege

in Bulletin Droit & Banque (2005), 36

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See detailInfluence of obesity on plasma lipid and lipoprotein concentrations in dogs.
Jeusette, Isabelle C; Lhoest, Estelle T; Istasse, Louis ULiege et al

in American Journal of Veterinary Research (2005), 66(1), 81-6

OBJECTIVE: To determine effects of obesity and diet in dogs on plasma lipid and lipoprotein concentrations by assaying plasma leptin and ghrelin concentrations and determining total plasma cholesterol and ... [more ▼]

OBJECTIVE: To determine effects of obesity and diet in dogs on plasma lipid and lipoprotein concentrations by assaying plasma leptin and ghrelin concentrations and determining total plasma cholesterol and triglyceride concentrations as well as the concentrations of cholesterol and triglycerides in various lipoprotein classes (ie, very-low-density, low-density, and high-density lipoproteins). ANIMALS: 24 Beagles; 12 lean (mean [+/- SEM] body weight, 12.7 +/- 0.7 kg) and 12 chronically obese (21.9 +/- 0.8 kg) dogs of both sexes, between 1 and 9 years old. PROCEDURES: Total plasma cholesterol and triglyceride concentrations; lipoprotein cholesterol and triglyceride concentrations; and plasma ghrelin, leptin, free fatty acids, insulin, and glucose concentrations were measured and compared between lean and obese dogs, both of which were fed a complete and balanced maintenance diet. Chronically obese dogs were subsequently fed a high-protein low-energy diet to evaluate effects of diet composition on plasma lipid and lipoprotein measurements. RESULTS: Chronic obesity resulted in a significant decrease in plasma ghrelin concentration and a significant increase in plasma leptin, cholesterol, and triglyceride concentrations in dogs. High total plasma cholesterol and triglyceride concentrations resulted from increased cholesterol and triglyceride concentrations in all lipoprotein fractions. In obese dogs, modification of diet composition resulted in beneficial effects on plasma lipid and leptin concentrations, even before weight loss was observed. CONCLUSIONS AND CLINICAL RELEVANCE: Correlations exist between obesity and plasma measurements (ie, lipoproteins, leptin, insulin, and ghrelin) commonly associated with obesity. Modification of diet composition to control energy intake improves plasma lipid and leptin concentrations in obese dogs. [less ▲]

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See detailLa réforme de Bologne et l’ULg
Lanneau, Catherine ULiege

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2005), XXVII(4), 37-41

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See detailMétaphysique phénoménologique
Seron, Denis ULiege

in Bulletin d'Analyse Phénoménologique (2005), 1(2), 3-174

The aim of this study is to give some guidelines for a phenomenological metaphysics. The author first questions the possibility and relevance of applying the phenomenological method in metaphysics, in ... [more ▼]

The aim of this study is to give some guidelines for a phenomenological metaphysics. The author first questions the possibility and relevance of applying the phenomenological method in metaphysics, in order to outline a metaphysics that would be not only a "metaphysical systematics" (in Peter Simons's sense), but also a phenomenological and "constitutive" metaphysics. Then he succinctly explores some basic questions of contemporary metaphysics, in a dialogue with the recent developments of "analytical" metaphysics: Armstrong's factualism, the relationship between logic and ontology, the ontological status of universals, maximalism and negative states of affairs, ontological dependence, Moore's paradox, etc. [less ▲]

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See detailReprésentations parentales et styles d'attachement dans une population de sujets délinquants sexuels
Cornet, Jean-Philippe; Mormont, Christian ULiege

in Forensic (2005), 21(2), 6-24

Les analyses statistiques montrent que le groupe composé de sujets délinquants sexuels se distingue du groupe des délinquants non sexuels et du groupe de sujets-contrôle par le fait qu'il tend à fournir ... [more ▼]

Les analyses statistiques montrent que le groupe composé de sujets délinquants sexuels se distingue du groupe des délinquants non sexuels et du groupe de sujets-contrôle par le fait qu'il tend à fournir des représentations moins négatives de la mère. Une analyse plus précise montre que le groupe de délinquants sexuels se différencie significativement des groupe de délinquants et de sujets-contrôle en ce qui concerne "l'agressivité du sujet envers sa mère" et "l'agressivité envers son père". Les délinquants sexuels se différencient également des sujets délinquants, mais non des sujets-contrôle, aux sous-échelles de "l'agressivité du père envers son fils", de "l'agressivité du père envers la mère" et de "l'indulgence de la mère". Finalement, les délinquants sexuels se distinguent également des autres sujets par leur style d'attachement de type évitant. [less ▲]

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See detailPharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor.
Ghuysen, Alexandre ULiege; Dogné, Jean-Michel; Chiap, Patrice ULiege et al

in Cardiovascular Drug Reviews (2005), 23(1), 1-14

BM-573 (N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), a torsemide derivative, is a novel non-carboxylic dual TXA2 synthase inhibitor and receptor antagonist. The pharmacological ... [more ▼]

BM-573 (N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), a torsemide derivative, is a novel non-carboxylic dual TXA2 synthase inhibitor and receptor antagonist. The pharmacological profile of the drug is characterized by a higher affinity for the thromboxane receptor than that of SQ-29548, one of the most powerful antagonists described to date, by a complete prevention of human platelet aggregation induced by arachidonic acid at a lower dose than either torsemide or sulotroban, and by a significantly prolonged closure time measured by the platelet function analyser (PFA-100). Moreover, at the concentrations of 1 and 10 microM, BM-573 completely prevented production of TXB2 by human platelets activated by 0.6 mM of arachidonic acid. BM-573 prevents rat fundus contraction induced by U-46619 but not by prostacyclin or other prostaglandins. Despite possessing a chemical structure very similar to that of a diuretic torsemide, BM-573 has no diuretic activity. BM-573 does not prolong bleeding time and, unlike some of the other sulfonylureas, has no effect on blood glucose levels. In vivo, BM-573 appears to have antiplatelet and antithrombotic activities since it reduced thrombus weight and prolonged the time to abdominal aorta occlusion induced by ferric chloride. BM-573 also relaxed rat aorta and guinea pig trachea precontracted with U-46619. In pigs, BM-573 completely antagonized pulmonary hypertensive effects of U-46619 and reduced the early phase of pulmonary hypertension in models of endotoxic shock and pulmonary embolism. Finally, BM-573 protected pigs from myocardial infarction induced by coronary thrombosis. These results suggest that BM-573 should be viewed as a promising therapeutic agent in the treatment of pulmonary hypertension and syndromes associated with platelet activation. [less ▲]

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See detailThe discovery and properties of pentaquarks
Stancu, Floarea ULiege

in International Journal of Modern Physics A : Particles & Fields, Gravitation, Cosmology, Nuclear Physics (2005), 20(2-3), 209-218

The pentaquarks are exotic baryons formed of four quarks and an antiquarks. Their existence has been discussed in the literature over the last 30 years or more, first in connection with kaon nucleon ... [more ▼]

The pentaquarks are exotic baryons formed of four quarks and an antiquarks. Their existence has been discussed in the literature over the last 30 years or more, first in connection with kaon nucleon scattering data. The subject has been revived by the end of 2002 when experimental evidence of a narrow baryon of strangeness S = +1, and mass M similar or equal to 1530 MeV has been found. This is interpreted as the lightest member of an SU(3)-flavor antidecuplet. Here we shall mainly review the predictions of pentaquark properties as e.g. mass, spin and parity, within constituent quark models. Both light and heavy pentaquarks will be presented. [less ▲]

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See detailLa pêche traditionnelle dans les pleines inondables du fleuve Ouémé au Bénin
Laleyé, Philippe; Akélé, David; Philippart, Jean-Claude ULiege

in Cahiers d'Ethologie (2005), 22(2), 25-38

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See detailConclusions
Kabamba, Bob ULiege; Verjans, Pierre ULiege

in Fédéralisme - Régionalisme (2005), volume 5(2004-2005), 103-108

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See detailCompte rendu de "Otrante. Art et littérature fantastiques. Jean Ray / John Flanders. Croisement d’ombres. Paris, Éditions KIMÉ, no 14, automne 2003"
Dozo, Björn-Olav ULiege

in Textyles : Revue des Lettres Belges de Langue Française (2005), 26-27

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See detailEGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response element
Manfroid, Isabelle ULiege; Van de Weerdt, Cécile ULiege; Baudhuin, Ariane et al

in Molecular & Cellular Endocrinology (2005), 229(1-2), 127-39

Normal and neoplastic human mammary gland cells are targets for the proliferative action of prolactin. These cells also synthesize prolactin, thereby inducing an autocrine/paracrine proliferative loop. We ... [more ▼]

Normal and neoplastic human mammary gland cells are targets for the proliferative action of prolactin. These cells also synthesize prolactin, thereby inducing an autocrine/paracrine proliferative loop. We present the first extensive analysis of the transcriptional regulation of the human prolactin gene (hPRL) in human mammary tumor cells, SK-BR-3. We show that the pituitary promoter is functional in these cells in the absence of the pituitary-specific factor Pit-1. Expression of exogenous Pit-1 or epidermal growth factor (EGF) treatment stimulates the transfected hPRL pituitary promoter and the endogenous hPRL expression. EGF stimulation is mediated by increased synthesis of c-fos and c-jun, resulting in AP-1 binding to the proximal hPRL pituitary promoter. This regulation involves the EGF receptor, possibly ErbB2 that is highly expressed in SK-BR-3 cells, and a PI3K/JNK pathway. The stimulation of hPRL gene transcription by EGF in mammary cells may include hPRL in a complex regulatory network controlling growth of human mammary cells. [less ▲]

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See detailAdherence And Colonization Properties Of Lactobacillus Rhamnosus Tb1, A Broiler Chicken Isolate
Bouzaine, T.; Dubois Dauphin, Robin ULiege; Thonart, Philippe ULiege et al

in Letters In Applied Microbiology (2005), 40(5),

Aims: Selected lactic acid bacteria (LAB) isolated from intestinal tract of chicken have been studied in order to investigate their ability to adhere in vitro to Basement Membrane Matrigel (BMM). A ... [more ▼]

Aims: Selected lactic acid bacteria (LAB) isolated from intestinal tract of chicken have been studied in order to investigate their ability to adhere in vitro to Basement Membrane Matrigel (BMM). A selected strain showing a good adherence in BMM test was used for in vivo colonization assays. Methods and Results: In vitro assessment of adhesion of broiler chicken isolates was performed using BMM assay. Among LAB strains tested, Lactobacillus rhamnosus TB1 showed a good adherence that was comparable to the one of an Escherichia coli EPEC strain used as positive control. For in vivo colonization assays this strain was fluorescently stained with the carboxyfluorescein diacetate succinimidyl ester (cFDA-SE) thus allowing its detection in different layers of intestinal tract after inoculation in broiler chicken. Further, stained L. rhamnosus were found with a highest value in rectum, jejunum and ileum both 3 and 24 h after administration. Conclusions: BMM assay is a quick method to test in vitro adhesion properties of bacterial strains and cFDASE- stained bacteria may be considered as an alternative method to test in vivo adhesion and colonization properties. Significance and Impact of the Study: Lactobacillus rhamnosus TB1 was therefore showed to be able to adhere strongly in vitro to BMM and in vivo to intestinal epithelial cells of chicken and may be considered as a potential probiotic for chicken. [less ▲]

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See detailAdherence to first-line antiretroviral regimens in Rwanda.
Demeester, Remy; Omes, Christine; Karasi, Jean Claude ULiege et al

in Journal of Acquired Immune Deficiency Syndromes [=JAIDS] (2005), 40(1), 113-4

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See detailJean Le Blond, premier traducteur français de l'Utopie
Dozo, Björn-Olav ULiege

in Lettres Romanes (2005), LIX(3-4), 187-210

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See detailFomitiporia tenuis and Fomitiporia aethiopica (Basidiomycetes, Hymenochaetales), two undescribed species from the Ethiopian highlands: taxonomy and phylogeny.
Decock, Cony; Bitew, Adane; Castillo Cabello, Gabriel ULiege

in Mycologia (2005), 97(1), 121-9

Fomitiporia tenuis sp. nov. and Fomitiporia aethiopica sp. nov. from the Ethiopian highlands are described. Both are characterized by a resupinate habit, globose, dextrinoid basidiospores, cystidioles ... [more ▼]

Fomitiporia tenuis sp. nov. and Fomitiporia aethiopica sp. nov. from the Ethiopian highlands are described. Both are characterized by a resupinate habit, globose, dextrinoid basidiospores, cystidioles, and respectively scarcity or absence of hymenial setae. Fomitiporia pseudopunctata and F. robusta are reported also in the same area. The preliminary phylogenetic relationships of F. tenuis, F. aethiopica and F. pseudopunctata are inferred from parsimony analysis based on partial nuclear ribosomal large subunit (nrLSU). A preliminary key to the poroid Hymenochaetales with dextrinoid basidiospores (Fomitiporia, Phellinus s.l., Pseudoinonotus) is proposed. [less ▲]

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See detailAnalysis of Pollen and Nectar of Arbutus unedo as a Food Source for Bombus terrestris (Hymenoptera : Apidae)
Rasmont, Pierre; Regali, Ariane; Ings, Thomas C. et al

in Journal of Economic Entomology (2005), 98(3), 656-663

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See detailAtelier 2 : Hyperpaysages
Partoune, Christine ULiege; Ericx, Michel

in Bulletin de la Société Géographique de Liège (2005), 45

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See detailEvolution des ressources forestières en Afrique de l’Ouest soudano-sahélienne au cours des 50 dernières années
Ariori, Serge Léopold; Ozer, Pierre ULiege

in Geo-Eco-Trop (2005), 29

On the basis of an exhaustive consultation of the literature describing the temporal evolution of land cover in arid, semiarid and dry subhumid regions of West Africa, this study shows that the ... [more ▼]

On the basis of an exhaustive consultation of the literature describing the temporal evolution of land cover in arid, semiarid and dry subhumid regions of West Africa, this study shows that the deforestation trend has been very important during the second half of the 20th century. This trend to deforestation is globally large (2% per year) and is clearly alarming. Although our results differ from FAO's official data, it is demonstrated that those are questionable. In addition, if dense woody formations have been strongly reduced in the study area, our study indicates that degraded woody formations are currently declining. Our results clearly go against the recent conclusions of some authors preaching the idea of a 'greening Sahel'. [less ▲]

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See detailAnomalies des cellules de l'immunite naturelle et risque infectieux chez le patient diabetique
Moutschen, Michel ULiege

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 541-4

This review addresses the recent litterature devoted to the risk of severe infections in patients with diabetes and to the potential influence of diabetes on the function of natural immunity. Although ... [more ▼]

This review addresses the recent litterature devoted to the risk of severe infections in patients with diabetes and to the potential influence of diabetes on the function of natural immunity. Although much controversy still exists regarding the incidence of infections in diabetic patients, several studies confirm that diabetes mellitus is associated with an increased severity and mortality in community acquired pneumonia. Furthermore, the risk of severe bacteremia (especially associated with Streptococcus pneumoniae) is higher in diabetic patients. Polynuclear neutrophils are clearly influenced by the diabetic state. On the one hand, their antimicrobial function is inhibited by hyperglycaemia, due to inhibition of G6PD or diversion of NADPH in the polyol pathway; on the other hand, the AGE/RAGE/NF-kappaB pathway involved in the pathogenesis of chronic complications of diabetes could also amplify inflammatory systemic manifestations associated with infections and play a role in the higher mortality rate observed in diabetic subjects with severe infections. These observations argue for the systematic vaccination of all diabetic patients against influenza and Streptococcus pneumoniae, for the reappraisal of diabetes as a significant pejorative risk factor in community acquired pneumonia and for intensive insulin therapy in all diabetic patients with severe infection. [less ▲]

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See detailLa dépression : la réponse thérapeutique (3/3)
Ansseau, Marc ULiege

in Tempo Médical (2005), 274

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See detailVisualizing flow vortices inside a single levitated drop
Amar, A; Groß-Hardt, E; Khrapitchev, AA et al

in Journal of Magnetic Resonance (2005), 177(1), 74-85

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See detailLa dépression : au cœur du mal (2/3).
Ansseau, Marc ULiege

in Tempo Médical (2005), 272

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See detailAbdominal aortic aneurysm.
SakalihasanN, Natzi ULiege; Limet, Raymond ULiege; Defawe, O. D.

in Lancet (2005), 365(9470), 1577-89

Abdominal aortic aneurysms cause 1.3% of all deaths among men aged 65-85 years in developed countries. These aneurysms are typically asymptomatic until the catastrophic event of rupture. Repair of large ... [more ▼]

Abdominal aortic aneurysms cause 1.3% of all deaths among men aged 65-85 years in developed countries. These aneurysms are typically asymptomatic until the catastrophic event of rupture. Repair of large or symptomatic aneurysms by open surgery or endovascular repair is recommended, whereas repair of small abdominal aortic aneurysms does not provide a significant benefit. Abdominal aortic aneurysm is linked to the degradation of the elastic media of the atheromatous aorta. An inflammatory cell infiltrate, neovascularisation, and production and activation of various proteases and cytokines contribute to the development of this disorder, although the underlying mechanisms are unknown. In this Seminar, we aim to provide an updated review of the pathophysiology, current and new diagnostic procedures, assessment, and treatment of abdominal aortic aneurysm to provide family practitioners with a working knowledge of this disorder. [less ▲]

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See detailPouvoir d'État et pouvoir sur les médias : l'hégémonie du capital et ses monopoles
Geuens, Geoffrey ULiege

in Quaderni : la Revue de la Communication (2005), 57 ("Gramsci, les médias et la culture")(Printemps), 93-100

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See detailCollaborative study of an liquid chromatographic method for the determination of R-timolol and other related substances in S-timolol maleate
Marini Djang'Eing'A, Roland ULiege; Matthijs, N.; Vanderheyden, Yvan et al

in Analytica Chimica Acta (2005), 546(2), 182-192

A collaborative study applying an enantiomeric liquid chromatographic (LC) method was carried out to determine the content of the enantiomeric impurity R-timolol and other related substances in three ... [more ▼]

A collaborative study applying an enantiomeric liquid chromatographic (LC) method was carried out to determine the content of the enantiomeric impurity R-timolol and other related substances in three different S-timolol maleate samples. Eight laboratories, all located in Europe, participated in the study. The quantitative results obtained were used to estimate the uncertainty on the content of the different impurities. For that purpose, a set-up was adapted from the ISO guidelines 5725-2, which allowed the estimation of the different variances, i.e. the between-laboratories (s(laboratories)(2)), the between-days (s(days)(2)) and the between-replicates (s(replicates)(2)), The variances of repeatability (s(r)(2)) and reproducibility (s(R)(2)) were then calculated using the equations s(r)(2) = s(replicates)(2) and s(R)(2) = s(replicates)(2) + s(days)(2) + s(laboratories)(2). For the timolol impurities, it was found that the estimated uncertainty seem to be concentration-dependent. Since the LC method which combines the compendial ones for enantiomeric purity and related substances testing was applied to evaluate uncertainty in this collaborative study, it was shown how a laboratory can evaluate the uncertainty of its results when applying the method in the future. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailAt Least Two Regions Of The Oncoprotein Tre2 Are Involved In Its Lack Of Gap Activity
Bizimungu, C.; Vandenbol, Micheline ULiege

in Biochemical and Biophysical Research Communications (2005), 335(3),

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See detailStructure of light and heavy pentaquarks
Stancu, Floarea ULiege

in International Journal of Modern Physics A : Particles & Fields, Gravitation, Cosmology, Nuclear Physics (2005), 20(8-9), 1797-1802

Light and heavy pentaquarks are described within a constituent quark model based on a spin-flavor hyperfine interaction. In this model the lowest state acquires positive parity. The masses of the light ... [more ▼]

Light and heavy pentaquarks are described within a constituent quark model based on a spin-flavor hyperfine interaction. In this model the lowest state acquires positive parity. The masses of the light antidecuplet members are calculated dynamically using a variational method. It is shown that the octet and antidecuplet states with the same quantum numbers mix ideally due to SU (3)(F) breaking. Masses of the charmed antisextet pentaquarks are predicted within the same model. [less ▲]

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See detailComparison of liaison N-tact PTH (diasorin) and N-tact PTH SPIRMA (diasorin) in hemodialyzed patients
Cavalier, Etienne ULiege; Delanaye, Pierre ULiege; Krzesinski, Jean-Marie ULiege et al

in Clinical Chemistry & Laboratory Medicine (2005), 43(8), 890-891

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See detailGomphillus morchelloides (Ostropales : Gomphillaceae), a new lichen species from Chile and Papua New Guinea
Lucking, R.; Sérusiaux, Emmanuel ULiege

in Bryologist (2005), 108(4, Winter), 487-490

Revision of two collections of Gomphillus from Papua New Guinea and Chile, previously identified as Gomphillus ophiosporus and G. calycioides, respectively, revealed that these represent an undescribed ... [more ▼]

Revision of two collections of Gomphillus from Papua New Guinea and Chile, previously identified as Gomphillus ophiosporus and G. calycioides, respectively, revealed that these represent an undescribed species, G. morchelloides Lucking [less ▲]

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See detailFirst paleoseismological constraints on the strongest earthquake in France (Provence) in the twentieth century
Chardon, D.; Hermitte, D.; Nguyen, Frédéric ULiege et al

in Geology (2005)

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See detailGomphillus caribaeus belongs in the new genus Bryogomphus (Lecanorales : Pilocarpaceae)
Lucking, R.; Buck, W. R.; Sérusiaux, Emmanuel ULiege et al

in Bryologist (2005), 108(4, Winter), 481-486

A revision of the lichen genus Gomphillus Nyl. in the Americas reveals that G. caribaeus W. R. Buck does not belong in that genus, but is a member of the Pilocarpaceae in the Lecanorales. Because of its ... [more ▼]

A revision of the lichen genus Gomphillus Nyl. in the Americas reveals that G. caribaeus W. R. Buck does not belong in that genus, but is a member of the Pilocarpaceae in the Lecanorales. Because of its distinctive features, the species cannot be accommodated in any of the known genera of that family, and the new genus Bryogomphus Lucking, W. R. Buck, Serus. [less ▲]

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See detailIntravenous iron and recombinant human erythropoietin in cancer patients.
Beguin, Yves ULiege

in Journal of Clinical Oncology (2005), 23(3), 651-2652-3

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See detailRecommendations for the registration of agents to be used in the prevention and treatment of glucocorticoid-induced osteoporosis: updated recommendations from the Group for the Respect of Ethics and Excellence in Science.
Abadie, Eric ULiege; Devogelaer, Jean-Pierre; Ringe, Johann D. et al

in Seminars in Arthritis & Rheumatism (2005), 35(1), 1-4

OBJECTIVES: The Group for the Respect and Excellence in Science (GREES) has reviewed and updated their recommendations for clinical trials to evaluate the efficacy and safety of new chemical entities to ... [more ▼]

OBJECTIVES: The Group for the Respect and Excellence in Science (GREES) has reviewed and updated their recommendations for clinical trials to evaluate the efficacy and safety of new chemical entities to be used in the treatment and prevention of glucocorticoid-induced osteoporosis (GIOP). METHODS: Consensus discussion of the committee. RESULTS: With the exception of steroid use posttransplantation, there is no need to differentiate between underlying diseases. Prevention and treatment for GIOP are dependent on exposure to glucocorticoids rather than T-scores as in postmenopausal osteoporosis (PMO). If fracture data are obtained for PMO, it need not be repeated for GIOP, relying instead on bone mineral density (BMD) trials of at least 1 year. GREES recommends several changes in the previous guidance for GIOP. The committee saw no need to repeat preclinical studies if those have been previously done to assure bone quality in PMO. Similarly, phase I and phase II trials, if careful dose selection has been done for PMO, should not be repeated. The "prevention" and "treatment" claims should remain. Since the most recent evidence suggests significant increase in fracture risk for daily doses of prednisone of 5 mg/day or equivalent, clinical trials should concentrate on patients receiving at least this daily dosage. The emergence of bisphosphonates as the reference treatment, together with the rapid bone loss and high fracture incidence in glucocorticoid users, necessitates recommending a noninferiority trial design with lumbar spine BMD as the primary endpoint after 1 year. CONCLUSIONS: Registration of new chemical entities to be used in the management of GIOP should be granted, based on a 1-year noninferiority trial, using BMD as primary outcome and alendronate or risedronate as comparator. Demonstration of antifracture efficacy should have been previously demonstrated in PMO. [less ▲]

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See detailHigh levels of p105 (NFKB1) and p100 (NFKB2) proteins in HPV16-transformed keratinocytes: role of E6 and E7 oncoproteins.
Havard, Laurence; Rahmouni, Souad ULiege; Boniver, Jacques ULiege et al

in Virology (2005), 331(2), 357-66

We have previously shown that functional components of the NF-kappaB signaling pathway are up-regulated and sequestered in the cytoplasm of human papillomavirus 16 (HPV16)-transformed cell lines leading ... [more ▼]

We have previously shown that functional components of the NF-kappaB signaling pathway are up-regulated and sequestered in the cytoplasm of human papillomavirus 16 (HPV16)-transformed cell lines leading to a reduced activity of NF-kappaB. In this study, we examined the expression of the NF-kappaB precursors p100 and p105 in keratinocytes transformed or not by HPV16. Western immunoblotting experiments demonstrated high levels of p100 and p105 proteins not only in HPV16+ cervical carcinoma-derived keratinocytes but also in keratinocytes stably transfected by HPV16 E6 or E7 oncogenes. Moreover, p100 and p105 proteins were predominantly cytoplasmic and nuclear in keratinocytes expressing E7 and E6, respectively. A predominantly cytoplasmic localization of E7 protein was also detected in all keratinocytes expressing E7. Our results suggest that HPV16 E6 and E7 proteins modulate the expression and the subcellular localization of p100 and p105 NF-kappaB precursors. [less ▲]

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