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See detailThe size of nanoparticles after their incorporation in gastroresistant spheroids
Duvivier, F; Grandfils, Christian ULg; Léonard, F et al

in Journal de Pharmacie de Belgique (1997), 52(3), 123

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See detailUne hyperparathyroïdie, vous êtes certain ?
Geenen, Vincent ULg

in Actualité Médicale Belge (1997), 541

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See detailEcotoxicological and pathological studies of common guillemots Uria aalge beached on the Belgian coast during six successive wintering periods (1989-90 to 1994-95)
Debacker, Virginie ULg; Holsbeek, Ludo; Tapia, German et al

in Diseases of Aquatic Organisms (1997), 29(3), 159-168

During 6 successive wintering periods, 727 common guillemots Uria aalge were recovered from Belgian beaches. One-third of the birds were already dead; the rest passed through rehabilitation centres where ... [more ▼]

During 6 successive wintering periods, 727 common guillemots Uria aalge were recovered from Belgian beaches. One-third of the birds were already dead; the rest passed through rehabilitation centres where they eventually died. All birds were monitored for general condition (body mass, fat reserves), eventual status of oiling and pathological changes (cachexia, acute hemorrhagic gastroenteropathy); 339 birds were sampled for trace metals (total and organic Hg, Cu, Zn, Fe, Cd) and PCB (polychlorinated biphenyl) analysis. Oiling is still a major cause of death for wintering pelagic seabirds: half of the birds showed signs of external or internal oiling, probably a still greater number of oiled birds never reach the shores. Although a low body mass can be considered a normal winter condition for wintering guillemots, pathology results showed that three-quarters of the studied animals were in a state of cachexia with emaciated pectoral muscle and lowered muscle lipid content. Elevated levels of Cu, Zn, Hg and PCBs were linked to the state of cachexia and may well represent an additional stress factor leading to the debilitation and death of part of the wintering guillemot population. [less ▲]

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See detailLes avatars de la conscience
Richelle, Marc ULg

in Bulletin de la Classe des Lettres et des Sciences Morales et Politiques (1997), 6e série, tome VIII(1-6), 13-47

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See detailAntitumor and radiosensitizing effects of (E)-2'-Deoxy-2'-(Fluoromethylene) cytidine, a novel inhibior of ribonucleotide diphosphate reductase on human colon carcinoma xenografts in nude mice.
Sun, Lin-Quan; Li, Ye-Xiong; Guillou, Louis et al

in Cancer Research (1997), 57

Antitumor and radiosensitizing effects of (E).2'-deoxy.2'-(fluromethyl ene) cytidine (FMdC), a novel inhibitor of ribonucleotide reductase, were evaluated on nude mice bearing s.c. xenografts and liver ... [more ▼]

Antitumor and radiosensitizing effects of (E).2'-deoxy.2'-(fluromethyl ene) cytidine (FMdC), a novel inhibitor of ribonucleotide reductase, were evaluated on nude mice bearing s.c. xenografts and liver metastases of a human colon carcinoma. FMdC given once daily or twice weekly has a dose-dependent antitumor effect. The maximum tolerated dose In the mice was reached with 10 mgi'kg applied daily over 12 days. Twice weekly administration of FMdC reduced its toxicity but lowered the antitumor effect. Treatment of preestablished liver micrometastases obtained via intrasplenic injection of tumor cells, with 5 or 10 mgfkg FMdC, signifi candy prolonged the survival of the mice as compared to controls (P < 0.025 and P < 0.001, respectively). Ten mg/kg resulted in longer survival than S mg/kg FMdC (P < 0.05). Radiotherapy alone of s.c. xenografts (10 fractions over 12 days) yielded the radiation dose required to produce local tumor control in 50% of the treated mice (TCD@O)of 43.0 Gy. When combined with FMdC, TCDsawas reduced to 22.5 and 19.0 Gy at doses of 5 and 10 mg/kg given i.p. 1 h before each irradiation, respec tively. The corresponding enhancement ratios were 1.91 and 2.43, respec lively. FMdC produced moderate and reversible myelosuppression. When 5 mg/kg FMdC was combined with irradiation, there was no increased skin or hematological toxicity as compared to radiotherapy or FMdC alone. At the 10 mg/kg level, however, lower leukocyte counts were observed. These results show that FMdC appears to be a potent anticancer drug and radiosensitizer [less ▲]

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See detailProtéinas placentárias em mamíferos
Melo de Sousa, Noelita; de Figueiredo, José Ricardo; Gonçalves, Paulo Bayard Dias et al

in Ciência Animal (1997), 7(1), 43-55

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins ... [more ▼]

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins, placental lactogens, interferon tau, pregnancy specific and pregnancy-associated glycoproteins. In spite of the importance of these studies, there are few papers that describe fundamental aspects of these placental proteins such as physical-chemical pregnancy diagnosis methods. Thus, the aim of this report is to present an overview on the major aspects of placental proteins studied up to now, as well as to consider perspectives for their applications in the future in veterinary practice. [less ▲]

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See detailLoss of calcyphosin gene expression in mouse and other rodents
Clément, S.; Dumont, J.; Schurmans, Stéphane ULg

in Biochemical and Biophysical Research Communications (1997), 232

alcyphosine-for calcium binding and regulated by cyclic AMP through phosphorylation protein-is a target of both the cyclic AMP and the Ca(+2)-phophatidylinositol cascades first isolated from dog thyroid ... [more ▼]

alcyphosine-for calcium binding and regulated by cyclic AMP through phosphorylation protein-is a target of both the cyclic AMP and the Ca(+2)-phophatidylinositol cascades first isolated from dog thyroid, and then from rabbit and human brain. Although the exact function of this 24kD protein is unknown, calcyphosine could be implicated in the cross-signaling between these cascades to coordinate cellular proliferation and differentiation. Here, we report the sequence of a pseudogene which is the murine calcyphosine homologue, and demonstrate that it represents the unique sequence homologous to the dog calcyphosine gene in the murine genome. The lack of expression of this murine pseudogene in brain and thyroid-two major sites of dog calcyphosine expression-was extended to 5 other rodents, and suggest the existence of alternative pathway(s) to fill the function of calcyphosine in rodents [less ▲]

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See detailAttitude des élèves face à l'école et au cours d'éducation physique, âge et retard scolaire
Piéron, Maurice; Delfosse, Catherine; Ledent, Maryse et al

in Revue de l'Education Physique (1997), 37(1), 31-41

Le terme motivation fait partie du langage habituel des psychologues, des enseignants, des sportifs,... Nous pourrions continuer cette liste sans parvenir à lui donner un caractère exhaustif. Parfois ... [more ▼]

Le terme motivation fait partie du langage habituel des psychologues, des enseignants, des sportifs,... Nous pourrions continuer cette liste sans parvenir à lui donner un caractère exhaustif. Parfois utilisé de manière abusive, ce concept présente néanmoins des aspects théoriques et pratiques fondamentaux. A la notion de motivation, on associe très fréquemment celle d'attitude. Toutes deux sont définies en référence à l'affect, c'est-à-dire à une impression d'attraction ou de répulsion vis-à-vis d'un objet déterminé. ... [less ▲]

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See detailComparison of hindquarter metabolite uptakes in Belgian Blue double-muscled bulls at maintenance or during fattening.
Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg; Diez, Marianne ULg et al

in Journal of Animal Science (1997), 75(12), 3331-41

Metabolism of muscle growth in the hindquarter was investigated by the arterio-venous difference (AVD) technique in Belgian Blue double-muscled type bulls at maintenance or at fattening. The bulls were ... [more ▼]

Metabolism of muscle growth in the hindquarter was investigated by the arterio-venous difference (AVD) technique in Belgian Blue double-muscled type bulls at maintenance or at fattening. The bulls were fitted with an aortic ultrasonic blood flow probe and with catheters in the aorta and vena cava. They were offered a diet allowing for maintenance (MP) during a period of 15 d, at the end of which measurements were made over 3 d. Bulls were then given a fattening diet (FP) and the measurements were repeated. Arterial blood flow was approximately 1 L/min greater when the bulls were standing than when lying. Blood flow was 2 L/min higher during FP than during MP. The AVD and uptake of glucose were maximal at 1400 and 1600. Uptake of alpha-amino nitrogen decreased immediately after a meal. The increase in glucose from MP to FP fitted very well with the calculated energy needs for muscle growth. The AVD and uptake of alpha-amino nitrogen, total amino acids, and total nonessential amino acids were negative during MP and positive and significantly higher during FP. There was also a significant increase in AVD and uptake of essential and branched-chain amino acids when the bulls were changed from MP to FP. When changing from maintenance to fattening, the incremental glucose and amino acid hindquarter uptake provided energy and supply for muscle protein accretion, respectively. The level of alanine transamination was also sharply reduced. [less ▲]

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See detailCombined Ring Inversion and Side Group Rotation in Geminal Diphosphoryl Substituted Pyrrolinoxyl Radicals: ESR Analysis of Chemical Exchange between Four Nonequivalent Sites
Rockenbauer, Antal; Mercier, Anne; Le Moigne, François et al

in Journal of Physical Chemistry A (1997), 101(43), 7965-7970

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found ... [more ▼]

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found, for the 2,2-disubstituted compounds 2 and 3, dramatic changes in the spectra were observed as a function of the temperature. These changes were explained by a four-site chemical exchange model including both ring inversion and hindered rotation around the carbon-phosphorus bonds. For radical 3, the presence of additional 5,5-dimethyl substitution can completely block rotations around carbon-phosphorus bonds for certain ring geometries, while for other ring conformations chemical exchange still occurs through combined inversionrotation processes. An effective two-site model composed of nonequivalent sites and a superposition model composed of a pair of exchanging conformers and a pair of nonexchanging conformers were used to simulate spectrum variations. A satisfactory fit was obtained over the entire temperature range investigated. From the temperature dependence of the exchange frequencies the potential barriers for ring inversion (27 kJ/mol), for combined inversion-rotation (11 kJ/mol), and for rotation around the carbon-phosphorus bonds (14 kJ/mol) were estimated. [less ▲]

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See detailThe TEL gene products: nuclear phosphoproteins with DNA binding properties.
Poirel, H.; Oury, Cécile ULg; Carron, Clémence et al

in Oncogene (1997)

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute ... [more ▼]

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events. [less ▲]

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See detailHuman follicular dendritic cells in vitro and follicular dendritic-cell-like cells.
Tsunoda, R.; Bosseloir, A.; Onozaki, K. et al

in Cell & Tissue Research (1997), 288(2), 381-9

Human follicular dendritic cell (FDC)-like cells (FLC) have been utilized for the in vitro analysis of germinal center reactions. However, there is no consensus whether FLC represent FDC in vitro. The ... [more ▼]

Human follicular dendritic cell (FDC)-like cells (FLC) have been utilized for the in vitro analysis of germinal center reactions. However, there is no consensus whether FLC represent FDC in vitro. The purpose of the present study has therefore been to determine distinguishing features of FDC and FLC in vitro. The expression of CD40, CD54, CD49d, cytokine (gamma-IFN and IL-4)-dependent MHC-class II, and CD106 was observed to be specific for the determination of FDC in long-term culture. The cytokine-dependent emperipolesis of germinal center B cells was establised as another discriminating property for FDC in vitro. In 2 out of 72 long-term cultures of FDC, we encountered dividing cells among the non-dividing population of FDC. The dividing cells expressed accessory molecules similar to those of FDC but showed emperipolesis only for the initial few days of their growth. FDC did not enhance the CD40-dependent proliferation of germinal center B cells; in contrast, FLC augumented it. Both types of cells produced a significant amount of cytokine-dependent IL-6. Further studies are needed to determine whether FLC originate from FDC in vitro. [less ▲]

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See detailRuptured Aneurysm of the Profunda Femoral Artery Associated with Polyaneurysmal Disease
Defraigne, Jean-Olivier ULg; Vasquez, C.; Limet, Raymond ULg

in Acta Chirurgica Belgica (1997), 97(2), 93-6

A 73-year-old man was admitted for rupture of an atherosclerotic aneurysm of the profunda femoris artery associated to popliteal and bilateral axillary arteries aneurysms. The aneurysm of the profunda ... [more ▼]

A 73-year-old man was admitted for rupture of an atherosclerotic aneurysm of the profunda femoris artery associated to popliteal and bilateral axillary arteries aneurysms. The aneurysm of the profunda femoris artery was developed between the branches of the crural nerves. Considering the patency of the superficial femoral artery and of the leg arterie, and to avoid injury to the crural nerve, no reconstruction of the profunda femoris was attempted. The aneurysm was ligated proximally and buttress sutures were placed on the site of rupture to achieve thrombosis of the aneurysms. Most of the published cases of aneurysm of the profunda femoris artery are false aneurysms developed after various trauma. Atherosclerotic aneurysm of the profunda femoris artery is a rare lesion and rupture is exceptional. [less ▲]

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See detailLes comportements des enseignants dans la perspective d'un traitement différencié des élèves
Piéron, Maurice; Ledent, Maryse; Pirottin, Véronique et al

in Revue de l'Education Physique (1997), 4

La pédagogie basée sur la théorie des "rythmes d'apprentissage" accorde une place privilégiée à l'individualisation et contredit le principe d'une programmation uniforme, valable pour tous. Toute classe ... [more ▼]

La pédagogie basée sur la théorie des "rythmes d'apprentissage" accorde une place privilégiée à l'individualisation et contredit le principe d'une programmation uniforme, valable pour tous. Toute classe est hétérogène, chaque enfant étant singulier, différent dans ses valeurs, ses attitudes, ses potentialités et ses compétences. Chacun apprend à un rythme différent, plus rapidement que la moyenne dans des domaines, moins rapidement dans d'autres. ... [less ▲]

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See detailSynthesis and characterization of monodisperse spherical zirconia particles
Van Cantfort, Olivier; Michaux, Bernard; Pirard, René ULg et al

in Journal of Sol-Gel Science and Technology (1997), 8

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See detailComparison of radiography , magnetic resonance imaging and surgical findings in dogs with elbow dysplasia
Snaps, Frédéric ULg; Balligand, Marc ULg; Saunders, J. et al

in American Journal of Veterinary Research (1997), 58(12), 1367-1370

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for ... [more ▼]

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for evaluation of fragmented medial coronoid process (FMCP) and lesions of the medial aspect of the humeral condyle (MAHC). Animals-18 dogs with elbow dysplasia. Procedure-Radiography of 22 cubital joints was performed. The 22 joints then underwent MRI. The scans were evaluated with regard to the shape and signal of the coronoid process; articular cartilage change, subchondral bone disruption of the MAHC. Surgical findings were used as the standard to calculate accuracy, sensitivity, specificity, and positive-and negative-predictive values for specific diagnosis of FMCP (free fragment) and lesions of the MAHC. Results-At surgery, 31.8% of the joints had FMCP (free), 36.4% had nondisplaced unmineralized coronoid process, and 27.2% had nondisplaced mineralized coronoid process, Eleven joints had lesions of the MAHC, and wear lesions were observed in 41% of the joints. On radiography, FMCP (free) was visualized in 9% of the joints and lesions of the MAHC were observed in 23%. MRI had the highest accuracy (95.5%), sensitivity (100%), and negative-predictive value (100%) for detection of FMCP (free), and had accuracy (91%), sensitivity (87.5%), specificity (92.5%), and positive (87.5%)- and negative (92.5%)- predictive values for detection of nondisplaced unmineralized coronoid process. Conclusions and Clinical relevance-Compared with radiography, MRI was useful for detection of nondisplaced unmineralized coronoid process; images consistently correlated with surgical findings. The technique is accurate and especially useful when radiographic findings are inconclusive. [less ▲]

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See detailTextural properties and thermal stability of silica-zirconia aerogels
Pirard, René ULg; Bonhomme, Damien; Kolibos, Sofia et al

in Journal of Sol-Gel Science and Technology (1997), 8

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Percentile (1997), 2

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See detailRecherches karstologiques au Sud Cameroun
Willems, Luc ULg

in Regards (1997), 28

Several karsts have been studied in South Cameroon, booth in gneiss and granite lithologies.

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See detailMulticité. Le jeu du développement urbain
Beckers, Jacqueline ULg; Demeuse, Yves; Merenne-Schoumaker, Bernadette ULg et al

in G.E.O. (1997), 41(Numéro spécial),

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la ... [more ▼]

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la maximisation des retombées pour la collectivité ; elle fait appel à des bureaux d’études qui doivent monter ces projets. Le jeu se joue sur un territoire (plateau de jeu) avec ses quartiers d’habitat, son centre, ses réseaux de communication et aussi 350 îlots colorés selon l’affectation du sol et leur statut (public et privé). Le jeu – qui se déroule aussi sur deux fois 50 minutes dans sa version courte (un projet) – permet d’abord à l’équipe municipale de définir ses critères de choix et aux bureaux d’étude de monter leur projet, il met ensuite les protagonistes en contact puis en débat avant le choix final. Outre le plateau figurant le territoire, le jeu comprend encore des fiches relatives aux équipements, des consignes particulières pour les membres du bureau d’études et de l’équipe municipale (dont une fiche budget et une fiche argumentaire). À l’issue du jeu, il est possible non seulement de mettre en évidence les facteurs de localisation des équipements mais également le jeu des acteurs et les contraintes d’une politique de développement communal. [less ▲]

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See detailPower system security assessment: a position paper
Marceau, R.J.; Endrenyi, J.; Allan, R. et al

in Electra (1997), 175

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See detailAlternative techniques of hysterectomy.
NISOLLE, Michelle ULg; Donnez, Jacques

in New England Journal of Medicine [=NEJM] (1997), 336(4), 291-2

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See detailCaractéristiques microbiologiques et organoleptiques du nététu du commerce.
N'dir, B.; Gningue, B. D.; Keita, N. G. et al

in Cahiers Agricultures (1997), 6

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See detailDe quelques problèmes posés par l'action directe de l'article 1798 du Code civil, note sous Liège (10e ch.), 23 mai 1996
Georges, Frédéric ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailFontes Graeci Sami, I. Η Σάμος στις πηγές από τον 8ο ως τον 6ο αι.
Vanhaegendoren, Koen ULg; Karla, Grammatiki

in Samiakes Meletēs (1997), 3

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See detailRheological characterization on the BaTiO3 sol-gel transition
Van Cantfort, Olivier; Brasseur, Alain; Michaux, Bernard et al

in Faraday Discussions (1997), 101

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See detailKarst non carbonaté au Cameroun méridional. L'exemple des grottes de Mfoula
Willems, Luc ULg; Pouclet, André; Vicat, Jean-Paul

in Würzburger Geographische Arbeiten (1997), 89

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See detailSpecies assemblages and indicator species: The need for a flexible asymmetrical approach
Dufrêne, Marc ULg; Legendre, P.

in Ecological Monographs (1997), 67(3), 345-366

This paper presents a new and simple method to find indicator species and species assemblages characterizing groups of sites. The novelty of our approach lies in the way we combine a species relative ... [more ▼]

This paper presents a new and simple method to find indicator species and species assemblages characterizing groups of sites. The novelty of our approach lies in the way we combine a species relative abundance with its relative frequency of occurrence in the various groups of sites. This index is maximum when all individuals of a species are found in a single group of sites and when the species occurs in all sites of that group; it is a symmetric indicator. The statistical significance of the species indicator values is evaluated using a randomization procedure. Contrary to TWINSPAN, our indicator index for a given species is independent of the other species relative abundances, and there is no need to use pseudospecies. The new method identifies indicator species for typologies of species releves obtained by any hierarchical or nonhierarchical classification procedure; its use is independent of the classification method. Because indicator species give ecological meaning to groups of sites, this method provides criteria to compare typologies, to identify where to stop dividing clusters into subsets, and to point out the main levels in a hierarchical classification of sites. Species can be grouped on the basis of their indicator values for each clustering level, the heterogeneous nature of species assemblages observed in any one site being well preserved. Such assemblages are usually a mixture of eurytopic (higher level) and stenotopic species (characteristic of lower level clusters). The species assemblage approach demonstrates the importance of the 'sampled patch size,' i.e., the diversity of sampled ecological combinations, when we compare the frequencies of core and Satellite species. A new way to present species-site tables, accounting for the hierarchical relationships among species, is proposed. A large data set of carabid beetle distributions in open habitats of Belgium is used as a case study to illustrate the new method. [less ▲]

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See detailOxydation photochimique de lixiviats de décharge
Deswaef, Sophie; Baidak, Alexandre; Crine, Michel ULg

in Tribune de l'Eau (La) (1997), 590-591

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See detailPhysical activity and cardiovascular risk factors in children. The Belgian Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Bjorntorp, P.

in Obesity Research (1997)

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See detailDarkness promotes flowering in the absolute long-day requiring plant, Lolium temulentum L. Ceres
Périlleux, Claire ULg; Bernier, Georges ULg; Kinet, Jean-Marie

in Journal of Experimental Botany (1997), 48(307), 349--351

Vegetative plants of the long-day grass Lolium temulentum L. Ceres were exposed to threshold long days or light breaks. Protracted darkness given just afterwards clearly promoted flowering and was weakly ... [more ▼]

Vegetative plants of the long-day grass Lolium temulentum L. Ceres were exposed to threshold long days or light breaks. Protracted darkness given just afterwards clearly promoted flowering and was weakly inductive on its own. The promotive effect of darkness was restricted to floral induction since further apical development was weak. [less ▲]

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See detailCompte rendu du Cahier de Linguistique française, n°14 : Lexique et pragmatique
Defays, Jean-Marc ULg

in Français Moderne (Le) (1997), (2), 239-244

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See detailBenchmarks for finite element modelling of bolted steel connections
Bursi, O.; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (1997), 43(Nos 1-3),

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See detailToxicological investigations on four sperm whales stranded on the Belgian coast: inoganic contaminants
Bouquegneau, Jean-Marie ULg; Debacker, Virginie ULg; Gobert, Sylvie ULg et al

in Bulletin de l'Institut Royal des Sciences Naturelles de Belgique. Sciences de la Terre (1997), 67

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See detailSédimentologie des Formations de Marteau, du Bois d'Ausse et de la partie inférieure de la Formation d'Acoz (Dévonien inférieur) dans l'Est de la Belgique, au bord nord de Massif de Stavelot
Goemara, E.; Catot, E.; Dejonghe, L. et al

in Memoirs of the Geological Survey of Belgium (1997), 42

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See detailThe Complete Genome Sequence Of The Gram-Positive Bacterium Bacillus Subtilis
Kunst, F.; Ogasawara, N.; Moszer, I. et al

in Nature (1997), 390(6657), 249-256

Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are ... [more ▼]

Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are represented once, while a quarter of the genome corresponds to several gene families that have been greatly expanded by gene duplication, the largest family containing 77 putative ATP-binding transport proteins. In addition, a large proportion of the genetic capacity is devoted to the utilization of a variety of carbon sources, including many plant-derived molecules. The identification of five signal peptidase genes, as well as several genes for components of the secretion apparatus, is important given the capacity of Bacillus strains to secrete large amounts of industrially important enzymes. Many of the genes are involved in the synthesis of secondary metabolites, including antibiotics, that are more typically associated with Streptomyces species. The genome contains at least ten prophages or remnants of prophages, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis. [less ▲]

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See detailConcordanze del «Canto novo» di Gabriele d’Annunzio.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailNos élèves préfèrent Pythagore à Newton
Monseur, Christian ULg

in Pilotinfo (1997), 20(septembre),

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See detailImmunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Donnez, Jacques

in Fertility and Sterility (1997), 68(5), 912-919

Objective: To assess the proliferative activity of eutopic and ectopic endometrium throughout the menstrual cycle and its correlation to steroid receptor content. Design: The immunohistochemical use of Ki ... [more ▼]

Objective: To assess the proliferative activity of eutopic and ectopic endometrium throughout the menstrual cycle and its correlation to steroid receptor content. Design: The immunohistochemical use of Ki 67 was applied to investigate the proliferation index. A recently advanced stereographic computer technology was used to investigate steroid receptors. Setting: University hospital department of gynecology. Patient(s): Biopsies of eutopic endometrium, black and red peritoneal endometriotic lesions, and ovarian endometriomas were taken from infertile patients and classified according to the phase of the cycle. Result(s): In normal endometrium, the glandular proliferation index was highest during the proliferative phase and was statistically significantly reduced during the secretory phase. No proliferative activity was observed in the late secretory phase. No statistically significant differences were found between ectopic endometrium and eutopic endometrium except during the late secretory phase, when proliferative activity was still present in endometriotic tissue. The stromal proliferation index was similar in red lesions, ovarian endometriomas, and eutopic endometrium during the secretory phase. In normal endometrium, the highest concentrations of estrogen receptors (ERs) and P receptors (PRs) occurred in the epithelial and stromal cells during the late proliferative phase of the menstrual cycle. Estrogen receptor and PR content declined throughout the secretory phase. In ectopic endometrium, PR persisted in the glandular epithelium during the late secretory phase. Estrogen receptors persisted in the glandular epithelium and stroma of red peritoneal lesions and ovarian endometriomas during the late secretory phase. Conclusion(s): The high proliferative activity and the persistence of ERs and PRs in the stroma of red lesions and ovarian endometriomas emphasize the primordial role of the stroma in the development of endometriosis and suggest different mechanisms of proliferation control from those observed in eutopic endometrium. [less ▲]

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See detailWhat Is the Risk of Transferral of an Undetected Neoplasm During Organ Transplantation?
Detry, Olivier ULg; Bonnet, Pierre ULg; Honore, Pierre ULg et al

in Transplantation Proceedings (1997), 29(5), 2410-1

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See detailPositron emission tomography in parkinsonism
Salmon, Eric ULg

in Acta Neurologica Belgica (1997), 97(3), 187-191

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See detailIdentification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with MHC class I molecules
Vanneste, Yves; Ntodou-Thomé, Agnès; Vandersmissen, Eric et al

in Journal of Neuroimmunology (1997), 76

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ... [more ▼]

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ± 5 ng immunoreactive (ir) NT/106 cells, of which 5% is associated with plasma cell membranes. HPLC analysis of NT-ir present in human TEC showed a major peak of NT-ir corresponding to NT1–13. NT-ir was not detected in the supernatant of human TEC cultures. Using an affinity column prepared with a anti-MHC class I monoclonal antibody, NT-ir-related peptides were retained on the column and eluted together with MHC class I-related proteins. According to the elution time on HPLC of these peptides, they correspond to intact NT1–13, as well as to smaller fragments of NT1–13. [less ▲]

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See detailManifestations indésirables des antidépresseurs
Charlier, Corinne ULg; Ansseau, Marc ULg; Pinto, Emmanuel ULg et al

in Toxicorama (1997), (Spécial LYON), 310-314

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See detailThe effects of ammonium sulphate deposition and root sinks on soil solution chemistry in coniferous forest soils
Carnol, Monique ULg; Ineson, Phil; Anderson, J. M. et al

in Biogeochemistry (1997), 38

The effects of enhanced (NH4)(2)SO4 deposition on soil solution cation and anion concentrations and annual ionic fluxes were followed using a standardised experimental protocol in six European coniferous ... [more ▼]

The effects of enhanced (NH4)(2)SO4 deposition on soil solution cation and anion concentrations and annual ionic fluxes were followed using a standardised experimental protocol in six European coniferous forests with contrasting soil types, pollution inputs and climate. Native soil cores containing a ceramic suction cup were installed in the field, roofed and watered every two weeks with local throughfall or local throughfall with added (NH4)(2)SO4 at 75 kg NH4+-N ha(-1) a(-1). Living root systems were established in half of the lysimeters. Untreated throughfall NH4+-N deposition at the sites ranged from 3.7 to 29 kg ha(-1) a(-1). Soil leachates were collected at two weekly intervals over 12 months and analysed for volume, and concentrations of major anions and cations. Increases in soil solution NO3- concentrations in response to N additions were observed after 4-9 months at three sites, whilst one sandy soil with high C:N ratio failed to nitrify under any of the treatments. Changes in NO3- concentrations in soil solution controlled soil solution cation concentrations in the five nitrifying soils, with Al3+ being the dominant cation in the more acid soils with low base saturation. The acidification responses of the soils to the (NH4)(2)SO4 additions were primarily related to the ability of the soils to nitrify the added NH4+. pH and soil texture seemed important in controlling NH4+ leaching in response to the treatments, with two less acidic, clay/clay loam sites showing almost total retention of added NH4+, whilst nearly 75% of the added N was leached as NH4+ at the acid sandy soils. The presence of living roots significantly reduced soil solution NO3- and associated cation concentrations at two of the six sites. The very different responses of the six soils to increased (NH4)(2)SO4 deposition emphasise that the establishment of N critical loads for forest soils need to allow for differences in N storage. capacity and nitrification potential. [less ▲]

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See detailDesign for an Ipriflavone Multicenter European Fracture Study
Reginster, Jean-Yves ULg; Bufalino, L.; Christiansen, C. et al

in Calcified Tissue International (1997), 61(Suppl 1), 28-32

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large ... [more ▼]

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large multicentric European study was designed and is presently ongoing. Included in the study were 460 Caucasian, nonobese postmenopausal women aged > 45 and < 75 years, menopaused for at least 12 months. Inclusion was on the basis of a lumbar bone mineral density (BMD) lower than 2 SD compared with healthy women aged 50 years, corresponding to values below 0.860 g/cm2 (antero-posterior measurement) by Hologic QDR 1000. Women with prevalent vertebral fractures were excluded as well as those presenting secondary osteoporosis or having been treated with medications that could affect bone metabolism. This study was designed as a 3-year, double-blind, placebo-controlled, parallel group study that randomized the women to the oral administration of either 3 x 200 mg/day of i.p. or placebo. All patients received a daily supplement of 500 mg calcium. The primary purpose of the study was to evaluate the efficacy of i.p. in preventing vertebral nontraumatic fractures. Fracture is defined here as a > or = 20% decrease in any anterior, central, or posterior T4-L4 vertebral height. Blinded vertebral X-ray readings and vertebral morphometry have been centralized in an independent Center, with standardized evaluation of two experts. Power calculations have been based on the hypothesis that 21% of placebo-treated patients would fracture within 3 years and that treatment with i.p. would lead to a 50% reduction in the incidence of fracture. Statistical tests have been designed to have a power of 80%, with a type I error equal to 5%. Secondary endpoints were changes in vertebral, radial, and femoral BMD. Centralized controls on 100% BMD scans would ensure the good quality of BMD readings. This study should verify the hypothesis that i.p. significantly decreases the risk of vertebral fracture in postmenopausal, osteoporotic women. [less ▲]

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See detailHemodynamic effects of increasing PEEP during mechanical ventilation in anesthetized patients
LAMBERMONT, Bernard ULg; Ghuysen, Alexandre ULg; D'Orio, Vincenzo ULg et al

in American Journal of Respiratory & Critical Care Medicine (1997), 2

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See detailAssessment of pain in herpes zoster: lessons learned from antiviral trials
Dworkin, R. H.; Carrington, D.; Cunningham, A. et al

in Antiviral Research (1997), 33(2), 73-85

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but ... [more ▼]

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review, recommendations for the design and analysis of future trials of antiviral agents in herpes zoster are proposed. The principal recommendation is that antiviral efficacy should be evaluated both by distinguishing post-herpetic neuralgia from acute pain and by considering pain as a continuum. The primary endpoint should address both the prevalence and duration of post-herpetic neuralgia and should be examined in those patients who have post-herpetic neuralgia. Adopting the proposed recommendations in design and analysis of future trials should facilitate comparison across trials of the efficacy of antiviral agents in the treatment of herpes zoster. [less ▲]

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See detailA role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm
Marine, Jean-Christophe; Bellefroid, Eric J.; Pendeville-Samain, Hélène ULg et al

in Mechanisms of Development (1997), 63(2), 211-25

Gli-type zinc finger proteins play important regulatory roles in vertebrate and invertebrate embryogenesis. In Xenopus, the Gli-type proteins XGli-3 and XGli-4 are first expressed in earliest stages of ... [more ▼]

Gli-type zinc finger proteins play important regulatory roles in vertebrate and invertebrate embryogenesis. In Xenopus, the Gli-type proteins XGli-3 and XGli-4 are first expressed in earliest stages of mesoderm and neural development. Transient transfection assays reveal that XGli-3 and XGli-4 can function as transcription repressors. Counteracting the Gli-protein repressor activity by ectopic expression of a fusion protein that contains the Gli-zinc finger cluster connected to the E1A activator domain in Xenopus embryos results in specific morphological alterations in the developing somites and in the central nervous system. Altered expression characteristics for a broad set of molecular markers highlighting specific aspects of mesodermal and neural differentiation demonstrate an important role for Gli-type zinc finger proteins in the early mesodermal and neural patterning of Xenopus embryos. [less ▲]

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See detailOnset Time of Neuromuscular Block and Intubating Conditions: Influence of Different Stimulation Patterns
Hans, Pol ULg; Dewé, Walthère ULg; Albert, Adelin ULg

in Acta Anaesthesiologica Belgica (1997), 48(1), 15-21

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See detailPromoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.
Kas, K.; Voz, Marianne ULg; Roijer, E. et al

in Nature Genetics (1997), 15(2), 170-4

Pleiomorphic adenoma of the salivary glands is a benign epithelial tumour occurring primarily in the major and minor salivary glands. It is by far the most common type of salivary gland tumour ... [more ▼]

Pleiomorphic adenoma of the salivary glands is a benign epithelial tumour occurring primarily in the major and minor salivary glands. It is by far the most common type of salivary gland tumour. Microscopically, pleiomorphic adenomas show a marked histological diversity with epithelial, myoepithelial and mesenchymal components in a variety of patterns. In addition to a cytogenetic subgroup with normal karyotypes, pleiomorphic adenomas are characterized by recurrent chromosome rearrangements, particularly reciprocal translocations, with breakpoints at 8q12, 3p21, and 12q13-15, in that order of frequency. The most common abnormality is a reciprocal t(3;8)(p21;q12). We here demonstrate that the t(3;8)(p21;q12) results in promoter swapping between PLAG1, a novel, developmentally regulated zinc finger gene at 8q12, and the constitutively expressed gene for beta-catenin (CTNNB1), a protein interface functioning in the WG/WNT signalling pathway and specification of cell fate during embryogenesis. Fusions occur in the 5'-non-coding regions of both genes, exchanging regulatory control elements while preserving the coding sequences. Due to the t(3;8)(p21;q12), PLAG1 is activated and expression levels of CTNNB1 are reduced. Activation of PLAG1 was also observed in an adenoma with a variant translocation t(8;15)(q12;q14). Our results indicate that PLAG1 activation due to promoter swapping is a crucial event in salivary gland tumourigenesis. [less ▲]

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See detailIntoxications par le Temik® chez les animaux domestiques et sauvages : un problème alarmant en Wallonie
Delaunois, Annie; Lessire, Françoise ULg; Ansay, M. et al

in Annales de Médecine Vétérinaire (1997), 141

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See detail"Saint Lambert au banquet de Jupille". Auguste Chauvin (1810-1884) et la peinture d'histoire
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (1997), T. XIII, n° 276

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See detailUse of the alpha parameter method to calculate matrix corrections for infinitely thick targets (TTPIXE) with two different incident beam energies
Delbrouck Habaru, J.; Roelandts, I.; Strivay, David ULg et al

in Nuclear Instruments & Methods in Physics Research Section B (1997), 129(1), 92-100

The alpha parameter correction method for calculating matrix effects in PIXE data does not require a priori knowledge of the major element composition of the matrix but implies the determination of a so ... [more ▼]

The alpha parameter correction method for calculating matrix effects in PIXE data does not require a priori knowledge of the major element composition of the matrix but implies the determination of a so-called alpha parameter linking two independent phenomena: X-ray absorption and proton energy loss. The method extrapolated to the infinitely thick targets (TTPIXE) has been previously studied using two PIXE measurements in two different geometric configurations. The present Study deals with the possibility of using pairs of PIXE measurements at two different energies to obtain the alpha corresponding to thick samples (TTPIXE). The experimental conditions and error minimization problems are discussed. General tables allowing an easy use of the method are presented. [less ▲]

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See detail1897-1997 Les cent ans de la section des Eaux et Forêts
Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(4), 236-238

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See detailA two-dimensional Navier-Stokes inverse solver for compressor and turbine blade design
Demeulenaere, A.; Léonard, Olivier ULg; Van den Braembussche, René

in Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy (1997), 211(4), 299-307

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on ... [more ▼]

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on the blade surface. The method solves the time-dependent Navier-Stokes equations in a numerical domain of which some boundaries (the blade walls) move during the transient part of the computation. The geometry modification algorithm is based on the transpiration principle: a normal velocity distribution is computed from the difference between the actual and prescribed pressure distributions, and is used to modify the blade shape. A time iteration is then performed on this new blade shape, taking into account the grid movement during the time stepping. A two-dimensional upwind finite-volume Navier-Stokes solver has been developed. The multiblock strategy allows for a selective concentration of the discretization points in the zones of higher gradients. Applications to turbine and compressor blade design illustrate the accuracy of the flow computation, the capabilities and efficiency of the inverse method. [less ▲]

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See detailAménagement et gestion des territoires : essai de bilan des recherches françaises
Merenne-Schoumaker, Bernadette ULg

in Intergeo Bulletin (1997), 128

Review of research funded by the CNRS within the framework of Section "Spaces, Territories, Societies"

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See detailA cinnabar local order in liquid II-VI compounds
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Ceolin, R. et al

in Physica B: Condensed Matter (1997)

A short wavelength (lambda=0.7 Aring) neutron scattering experiment has been performed on the II-VI compounds HgS, HgSe and Zn xHg 1-xTe. Liquid HgS can be viewed as a distortion of the blende structure ... [more ▼]

A short wavelength (lambda=0.7 Aring) neutron scattering experiment has been performed on the II-VI compounds HgS, HgSe and Zn xHg 1-xTe. Liquid HgS can be viewed as a distortion of the blende structure; we show that this distortion decreases gradually with temperature. For Zn xHg 1-xTe, we show that the transition between the six coordinated HgTe liquid and the four coordinated ZnTe liquid is not continuous, the intermediate phase being a deformed cinnabar one [less ▲]

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See detail67-kD laminin receptor expression correlates with worse prognostic indicators in non-small cell lung carcinomas.
Fontanini, G.; Vignati, S.; Chine, S. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1997), 3(2), 227-31

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67 ... [more ▼]

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67-kDa laminin receptor. Sixty-one of 72 patients (84.7%) displayed a MLuC5-positive reaction, which was usually localized in both the inner surface of the plasmatic membranes and the cytoplasm of neoplastic cells. When we compared the laminin receptor expression with clinicopathological and biological parameters such as histotype, grading, T status, N status, ploidy, proliferative activity, vessel invasion, and p53 protein accumulation, the following results were observed: (a) the mean expression of the receptor was higher in the group of patients with metastatic nodal involvement than in those with uninvolved lymph nodes (P = 0.02); (b) a high Ki-67 score (>13% of positive cells) was observed in tumors with a higher mean value of laminin receptor (P = 0.004); (c) the tumors harboring neoplastic emboli in their vessels showed a higher laminin receptor immunoreactivity (P = 0.02); and (d) a borderline association was found between the high mean value of laminin receptor immunopositivity and p53 accumulation in neoplastic cell nuclei (P = 0.05). Our observations indicate that detection of high tissue levels of 67-kDa laminin receptor is associated with an invasive phenotype in non-small cell lung cancer and may provide further information in the biological characterization of this type of cancer. [less ▲]

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See detailQuantitative ultrasound techniques for the assessment of osteoporosis : Expert agreement on current status
Glüer, CC; Reginster, Jean-Yves ULg

in Journal of Bone and Mineral Research (1997), 12(8), 1280-1288

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See detailBacterial Constituents .71. Absolute Configuration Of The Isopyoverdin Chromophore
Michalke, R.; Taraz, K.; Budzikiewicz, H. et al

in Zeitschrift Fur Naturforschung C-A Journal of Biosciences (1997), 52(7-8),

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See detailUne chambre noire pour l’analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1997), 33

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See detailMise au point d'une technique de culture in vitro d'embryons immatures de Phaseolus.
Mergeai, Guy ULg; Schmit, V.; Baudoin, Jean-Pierre ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(1),

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See detailRelationship of human follicular diameter with oocyte fertilization and development after in-vitro fertilization or intracytoplasmic sperm injection.
Ectors, Fabien ULg; Vanderzwalmen, P.; Van Hoeck, J. et al

in Human Reproduction (1997), 12(9), 2002-2005

The aim of this work was to evaluate the relationship between follicular size at the time of oocyte retrieval, and the subsequent oocyte competence to be fertilized and to develop in vitro. All the ... [more ▼]

The aim of this work was to evaluate the relationship between follicular size at the time of oocyte retrieval, and the subsequent oocyte competence to be fertilized and to develop in vitro. All the obtained oocytes were classified according to the corresponding volume of aspirated follicular fluid. Aspirated volume of follicular fluid <2 ml corresponded to a follicular diameter <16 mm and constituted the small size group. Volume of follicular fluid from 2 to 6 ml corresponded to a diameter from 16 to 23 mm and constituted the medium size group. The large size group contained follicles with diameter >23 mm and corresponded to an aspirated volume of follicular fluid of >6 ml. A progressive and significant increase in the rates of oocytes with a first polar body was observed from the small size group to the other groups and from the medium to the large size group: 75.3, 85.9 and 95.3% respectively. After classical in-vitro fertilization (IVF), significantly better rates of fertilization and development were obtained in the medium size group compared to the two other groups. Moreover, a positive relationship was observed between follicular diameter and rates of embryos scored as 'good' when oocytes were fertilized by intracytoplasmic sperm injection (ICSI). These results demonstrated that follicular size is positively related to the oocyte ability to be fertilized and to develop. Although oocytes from small follicles gave lower percentages of development probably due to partial oocyte incompetence, they allowed an increase in the total number of embryos scored as 'good'. [less ▲]

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See detailAppraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines.
Monroe, E. W.; Daly, Adrian ULg; Shalhoub, R. F.

in Journal of Allergy and Clinical Immunology (The) (1997), 99(2), 798-806

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and ... [more ▼]

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and the number of newer drugs available for clinical use is growing. Various methods have been used to assess antihistaminic activity, the most popular of which is the epicutaneous histamine-induced wheal and flare. This test relies on the ability of epicutaneously injected histamine to bring about the wheal and flare, a neurovascular response that involves reflex vasodilation (flare) and local swelling caused by plasma extravasation (wheal). Antihistamines have been compared on the basis of their ability to block the histamine-induced wheal and flare in the skin. Results of these trials have been applied to predict the global antiallergic efficacy of various antihistamines. The review has examined the reliability of suppression of the histamine wheal and flare reaction in the skin to predict an antihistamine's clinical efficacy in two common allergic diseases seasonal allergic rhinitis and chronic idiopathic urticaria. Although histamine is one mediator in the allergic response in the skin and nasal mucosa, many other agents are important modulators of the allergic response. In addition, the major structural and functional differences that exist between the nasal mucosa and the skin affect the type of local response. These manifest themselves as differences between the responses to antigen and histamine challenge in the skin and the nose. The allergic responses in these tissues are not simply the consequence of one chemical but are the result of a cascade of interactions among various cells and mediators. The clinical manifestations of these complex interactions obviously cannot be fully replicated by injection of one chemical mediator, histamine, into the outer layer of the skin. Studies with antihistamines have shown that certain drugs, such as cetirizine, are more suppressive than others (loratadine, terfenadine) in controlling the histamine-induced wheal and flare reaction in the skin. When the clinical efficacy of these medications is compared in clinical trials in seasonal allergic rhinitis and chronic idiopathic urticaria, all are equally efficacious in controlling symptoms. Although the histamine-induced wheal and flare reaction can serve as a useful clinical pharmacologic test to assess dose-response relations for an antihistamine, its lack of correlation with clinical responses among antihistamines indicates that this model should not be used to predict or compare clinical efficacies of antihistamines in seasonal allergic rhinitis and chronic idiopathic urticaria. [less ▲]

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See detailDissociations between the processing of proper and common names
Brédart, Serge ULg; Brennen, T.; Valentine, T.

in Cognitive Neuropsychology (1997), 14(2), 209-217

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See detailAbdominal sequelae after pedicled TRAM flap breast reconstruction
PETIT, JY; RIETJENS, M; FERREIRA, M et al

in Plastic and Reconstructive Surgery (1997), 99

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants ... [more ▼]

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants. Although such enthusiasm for the transverse rectus abdominis musculocutaneous (TRAM) flap is justified in what concerns the final cosmetic result of the reconstructed breast, the risk of abdominal sequelae should be explained to the patient. Abdominal scarring, parietal weakness, strength loss, and back pain have been recorded in a series of pedicled TRAM flap reconstructions performed at the Institut Gustave-Roussy before 1991. Cosmetic results of the abdomen were tested by three independent judges on the photographs taken of 132 patients. The global appearance of the abdomen was rated as "natural" in 70 percent of the patients. The umbilical scar was unacceptable in 25 percent and very good or not visible in 21 percent. The lower abdominal scar was rated as "not acceptable" in 35 percent. Abdominal strength was tested among the 38 patients who underwent both preoperative and postoperative muscular testing, of whom 18 had single-pedicled and 20 had bipedicled TRAM flap reconstructions. In the first group, the physiotherapist observed an impairment of function of the upper portion of the rectus abdominis and of the oblique muscle in almost 50 percent. In the second group, the same muscles were more severely impaired (in 60 percent), as well as the function of the lower portion of the rectus (in 15 percent). The percentage of patients complaining of "light back pain" in the 6-month postoperative period was 55 percent in the single-pedicle group and 30 percent in the double-pedicle group. However, 20 percent of the bipedicled patients complained of "severe" back pain, while there was none in the single-pedicled group. In conclusion, abdominal sequelae after TRAM flap breast reconstruction should not be underestimated and constitute one of the drawbacks of the technique when it is compared with reconstruction with a prosthesis. [less ▲]

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See detail"Exolysosomes", Enzyme-Containing Vesicles in the Ecdysial Space of Molting Crabs
Compère, Philippe ULg; Bouchtia, Hicham; Thiry, Marc ULg et al

in Journal of Structural Biology (1997), 119(3), 247-59

Free vesicle-like bodies (VLBs) present in the ecdysial space of cuticle regions undergoing degradation during preecdysis of the Atlantic shore crab Carcinus maenas have been interpreted either as ... [more ▼]

Free vesicle-like bodies (VLBs) present in the ecdysial space of cuticle regions undergoing degradation during preecdysis of the Atlantic shore crab Carcinus maenas have been interpreted either as infectious organisms or as secretion structures associated with degradation of the old cuticle. Ultrastructural, cytochemical, and immunocytological investigations were performed to test these hypotheses and to see whether VLBs are peculiar to this crab species. Similar VLBs were systematically found in two other preecdysial crabs, Cancer pagurus and Macropipus puber. In Car, maenas, they originate during early premolt inside Golgi buddings and are often gathered into large vacuoles in epidermal cells. The histochemical azo-dye technique and a cerium-based cytochemical method revealed acid phosphatase activity in both the ecdysial space and the VLBs, while Feulgen's method and immunocytological labeling always failed to reveal any DNA or RNA in either the ecdysial space or the VLBs. We conclude that VLBs are not infectious organisms but "extracellular" cuticle-degrading organelles of lysosomal origin and propose to coin them "exolysosomes." [less ▲]

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See detailPrimary radiation therapy or surgery combined or not to radiation therapy in the management of squamous cell carcinoma of the penis
Zouhair, Abderrahim; Ozsahin, Mahmut; Douglas, Pelham et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 39(2 (Supplément)), 295

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See detailStudies on the O-J-I-P transient of chlorophyll fluorescence in relation to photosystem II assembly and heterogeneity in plastids of greening barley
Barthelemy, X.; Popovic, R.; Franck, Fabrice ULg

in Journal of Photochemistry and Photobiology B : Biology (1997), 39(3), 213-218

The polyphasic variable fluorescence in saturating light (O-J-I-P transient, Strasser et al. (1995) Photochem. Photobiol. 61: 21-42) has been investigated in etiochloroplasts during the greening of ... [more ▼]

The polyphasic variable fluorescence in saturating light (O-J-I-P transient, Strasser et al. (1995) Photochem. Photobiol. 61: 21-42) has been investigated in etiochloroplasts during the greening of etiolated leaves of Hordeum vulgare. The initial photochemical phase (O-J) due to reduction of the primary quinone acceptor Q(A) was found to represent a constant proportion (65-70%) of total variable fluorescence independent of greening time. The partial fluorescence quenching in the Q(A)-reduced state seems, therefore, to represent a basic property of PSII electron transport. The biphasic character of the slower J-I-P transient due to reduction of the plastoquinone pool developed progressively during the first hours of greening. in the same period of lime the proportion and rate constant of rapid PSII alpha sub-population increased, as calculated from the induction curve in the presence of DCMU. Etiochloroplasts or chloroplasts resuspended in low salt medium showed a low I level, which was restored upon readdition of 5 mM MgCl2 and NaCl. Salts also increased the apparent proportion of PSII alpha. These results suggest that the J-I and I-P phases of the induction curve are related to different rates of plastoquinone photoreduction by two distinct PSII populations. The effects of DMQ and of DCBQ on the O-J-I-P transient were also studied in (etio-)chloroplasts, In addition to the already reported quenching of the initial (F-0) and variable fluorescence by DCBQ, a slow fluorescence increase phase was found to appear upon the addition of DCBQ but not of DMQ. The latter observations confirm that DCBQ differs from DMQ by its higher efficiency as PSII electron acceptor. (C) 1997 Elsevier Science S.A. [less ▲]

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See detailAnomalously large Born effective charges in cubic WO3
Detraux, F.; Ghosez, Philippe ULg; Gonze, X.

in Physical Review. B : Condensed Matter (1997), 56(3), 983-985

Within density-functional theory, we compute the Born effective charges of tungsten trioxyde in its reference cubic phase (defect-perovskite structure). For the tungsten atom, the effective charge tensor ... [more ▼]

Within density-functional theory, we compute the Born effective charges of tungsten trioxyde in its reference cubic phase (defect-perovskite structure). For the tungsten atom, the effective charge tensor is isotropic, with Z(W)*=+12.51. For the oxygen atoms, the two independent components of the tensor, corresponding, respectively, to a displacement of the atom parallel or perpendicular to the W-O bond, have the values Z(O parallel to)* = -9.13 and Z(O perpendicular to)* = -1.68. Z(W)* and Z(O parallel to)* are anomalously large with respect to the nominal ionic charges (+6 on W and -2 on O), but compatible with the Born effective charges found in related ABO(3)-perovskite compounds. [less ▲]

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See detailProcesses in regions of freshwater influence (ROFI)
Nihoul, Jacques ULg; Djenidi, Salim ULg; Huthnance, J. M. et al

in Journal of Marine Systems (1997), 12(1-4), 1-2

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See detailModulation of lung inflammation in the control of bovine respiratory disease
Van de Weerdt, ML; Lekeux, Pierre ULg

in Bovine Practitioner (1997), 31.1

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible ... [more ▼]

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible preventive treatments will not be discussed in this review. [less ▲]

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See detailFibres alimentaires chez le chien II. Effets sur la vidange gastrique et le transit gastro-intestinal
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is ... [more ▼]

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is also given. The incorporation of fibres in the diet is one of many other factors which influence the mechanisms of emptying in the gastrointestinal tract. The effect of dietary fibres is also discussed in other monogastric species [less ▲]

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See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailReactivite bronchique chez les patients diabetiques.
Piéron, Maurice ULg; Scheen, André ULg; Corhay, Jean-Louis ULg et al

in Revue des Maladies Respiratoires (1997), 14(5), 379-85

The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on ... [more ▼]

The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on the ventilatory parameters measured during a methacholine-induced bronchoconstriction test. Ten insulin-dependent diabetic patients without CAN, ten insulin-dependent diabetic patients with CAN and ten healthy volunteers, all non-smokers and free of respiratory symptoms, have undergone a functional respiratory check-up before the methacholine test. The presence of CAN was classically studied by the decrease in heart rate changes during three standardized tests (deep breathing at 6 cycles/min, Valsalva manoeuver, orthostatism) which all mainly explore the parasympathetic function. The bronchial response to methacholine was similar in the healthy subjects and in the diabetic patients without CAN. However, the fall in forced expiratory volume in 1 second induced by the highest dose of methacholine was significantly less marked in the diabetic subjects with CAN than in the two other groups. These results suggest that the diabetic autonomic neuropathy also involves the vagal innervation of the respiratory tract. [less ▲]

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See detailFluidothérapie parentérale pratique chez les bovins
Rollin, Frédéric ULg

in Annales de Médecine Vétérinaire (1997), 141(2), 89-111

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte ... [more ▼]

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte disturbances and glycemia. The various classes of fluids are then considered as a function of the indications. Use of transfusion, hypertonic solutions and parenteral nutrition is broached. Routes and techniques of fluid administration are detailed. Obstacles encountered by the bovine practitioner when using parenteral fluid therapy are emphasized just as the means to overcome them. In this regard, it is described how to correctly prepare fluids for suited parenteral use in cattle. In fact, the present laws do not given this allowance to the practitioners. However, in most cases, it constitutes the only economical option avoiding worthless sufferings and death of the animal. [less ▲]

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See detailBounds on the Soft Pomeron Intercept
Cudell, Jean-René ULg; Kang, Kyungsik; Kim, Sung Ku

in Physics Letters B (1997), 395

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See detailSpecific Modulation Of The Fusogenic Properties Of The Alzheimer Beta-Amyloid Peptide By Apolipoprotein E Isoforms
Pillot, T.; Goethals, M.; Vanloo, B. et al

in European Journal of Biochemistry (1997), 243(3), 650-9

C-terminal fragments of the Alzheimer amyloid peptide (amino acids 29-40 and 29-42) have physico-chemical properties related to those of the fusion peptides of viral proteins and they are able to induce ... [more ▼]

C-terminal fragments of the Alzheimer amyloid peptide (amino acids 29-40 and 29-42) have physico-chemical properties related to those of the fusion peptides of viral proteins and they are able to induce the fusion of liposomes in vitro. We proposed that these properties could mediate a direct interaction of the amyloid peptide with cell membranes and account for part of the cytotoxicity of the amyloid peptide. In view of the epidemiologic and biochemical linkages between the pathology of Alzheimer's disease and apolipoprotein E (apoE) polymorphism, we examined the potential interaction between the three common apoE isoforms and the C-terminal fragments of the amyloid peptide. We show that, at low concentration, only apoE2 and apoE3 are potent inhibitors of the amyloid peptide fusogenic and aggregational properties, whereas the apoE4 isoform has no effect. We further show that the protective effect of apoE is mediated by the formation of stable apoE/amyloid peptide complexes, as determined by tryptophan emission fluorescence measurements and by gel electrophoresis. The interaction specificity between apoE2 and apoE3 and the amyloid fragments is demonstrated here, since other apolipoproteins (e.g. apolipoprotein A-I and A-II), with similar amphipathic structures, do not interact with the amyloid C-terminal fragments. Finally, we show that, reciprocally, the amyloid peptide can interact directly with the apoE2 and apoE3 isoforms to decrease or perturb their normal association with lipids. These data suggest that the 29-40 and 29-42 domains of the amyloid peptide could be critical for the amyloid-apoE interaction, and that apoE2 and apoE3 isoforms, but not apoE4, could play a protective role against the formation of amyloid aggregates and/or against their interaction with cellular membranes. [less ▲]

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See detailEnergy savings in methanol synthesis: Use of heat integration techniques and simulation tools.
Maréchal, François; Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Computers & Chemical Engineering (1997), 21(Suppl. S), 511-516

Starting with a classical process for producing methanol using the reforming and synthesis steps, a combined approach applying simulation models and a new synthesis strategy, named Effect Modelling and ... [more ▼]

Starting with a classical process for producing methanol using the reforming and synthesis steps, a combined approach applying simulation models and a new synthesis strategy, named Effect Modelling and Optimisation (EMO), has been used to optimise the energy efficiency of the process. The method allows to identify different ways of improving the energy efficiency of the process. The modifications concern the synthesis reactor and the reforming reactor designs, the exploitation of the purge stream as fuel gas to satisfy the process requirement and its integration to a gas turbine system. The EMO approach allows to target the impact of a process modification at the global level of the energy cost of the process, including the combined production of heat and mechanical power in a gas turbine and the steam network. Starting with a classical methane conversion of 60% for the classical system, we identify solutions with up to 93% of the overall methane conversion when we transform the net mechanical power produced into methane savings at the country level. The interest of the approach is the possibility of computing the impact of the process modifications suggested by the analysis of the shape of the heat cascade on the overall energy balance of the plant without having to simulate in many details the steam and the heat exchanger network. [less ▲]

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See detailLa violence dans les stades de football
Comeron, Manuel ULg

in Revue Générale (1997), (2), 21-30

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See detailRelative and absolute in Leibniz' physics and metaphysics
Bouquiaux, Laurence ULg

in Epistemologia (1997)

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See detailA primal-dual approach in truss topology optimization
Beekers, M.; Fleury, Claude ULg

in Computers & Structures (1997), 64(1-4), 77-88

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are ... [more ▼]

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are bounds on bar volumes and the satisfaction of equilibrium equations. For a single load case and without bounds on bar volumes, the problem can be written as a linear programming problem with nodal displacements as variables. The addition to the objective function of a quadratic term vanishing at the optimum allows us to use a dual solution scheme. A conjugate gradient method is well suited to maximize the dual function. Several ground structures are introduced. For large networks, those where each node is connected to those situated in a certain vicinity give a good compromise between generating a reasonable number of bars and obtaining a sufficient number of possible directions. Some examples taken from the literature are treated to illustrate the quality of the solution and the influence of initial topology. (C) 1997 Civil-Comp Ltd and Elsevier Science Ltd. [less ▲]

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See detailInduction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells.
Polette, M.; Gilles, Christine ULg; Marchand, V. et al

in Clinical & Experimental Metastasis (1997), 15(2), 157-63

Membrane-type matrix metalloproteinase 1 (MT1-MMP) has been recently described as an activator of proMMP-2 (MMP-2) which is involved in tumor invasion. We have shown by in situ hybridization that MT1-MMP ... [more ▼]

Membrane-type matrix metalloproteinase 1 (MT1-MMP) has been recently described as an activator of proMMP-2 (MMP-2) which is involved in tumor invasion. We have shown by in situ hybridization that MT1-MMP is produced by stromal cells in close contact to preinvasive and invasive tumor cells of breast carcinomas. Of particular interest was the observation that some fibroblasts express this enzyme in focal areas in preinvasive lesions, suggesting that particular tumor cells may stimulate fibroblasts to produce MT1-MMP. We have therefore compared the ability of two different breast cancer cell lines, one non-invasive (MCF7) and one invasive (MDA-MB-231) to stimulate MT1-MMP production in human fibroblasts with consequent proMMP-2-activation. The MDA-MB-231 conditioned medium induced MT1-MMP mRNAs in human fibroblasts and a parallel activation of proMMP-2 whereas MCF7 conditioned medium did not have any effect. These results suggest the existence of soluble factor(s) secreted by invasive or some preinvasive breast tumor cells which stimulate fibroblasts to produce and activate MMPs, and emphasize the cooperation between cancer and stromal cells in tumor invasion. [less ▲]

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See detailCompte rendu de VAUCHEZ (A.), La spiritualité du Moyen Age occidental VIIIe-XIIIe siècle, Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailFloctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs
Lequesne, M; Fannius, J; Reginster, Jean-Yves ULg et al

in Revue du Rhumatisme (English ed.) (1997), 64(5), 327-333

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See detailEnantioseparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using mixtures of anionic and uncharged beta-cyclodextrins as chiral additives.
Fillet, Marianne ULg; Hubert, Philippe ULg; Crommen, Jacques ULg

in Electrophoresis (1997), 18(6), 1013-8

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta ... [more ▼]

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta-cyclodextrin) in combination with a neutral cyclodextrin as chiral additives to a pH 3 phosphoric acid-triethanolamine buffer. In the presence of a negatively charged cyclodextrin, the analytes were given an appropriate mobility but relatively low enantioselectivities were generally obtained when such a cyclodextrin was the only selector added to the buffer. The addition of an uncharged cyclodextrin, such as the native beta-cyclodextrin or one of its derivatives (dimethyl-, trimethyl- and hydroxypropyl-beta-cyclodextrin), to this kind of buffer containing an anionic cyclodextrin, was found to give rise to considerable improvement in chiral resolution for all compounds studied. Resolution and analysis time were optimized by varying the nature and concentration of the two cyclodextrins. The best compromise was usually achieved by the simultaneous addition of sulfobutyl ether beta-cyclodextrin and trimethyl-beta-cyclodextrin. Under optimum conditions, the enantiomers of all NSAIDs examined could be completely separated (most often with resolution values higher than 5) in short analysis times (generally lower than 15 min). [less ▲]

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See detailFatal Massive Liver Steatosis. A Clinicopathological Case Report
de Leval, Laurence ULg; Lambermont, Bernard ULg; D'Orio, Vincenzo ULg et al

in Acta Gastro-Enterologica Belgica (1997), 60(2, Apr-Jun), 180-183

Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman ... [more ▼]

Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman under anticonvulsivant therapy and with medications for a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) who presented with rapidly progressive cholestasis and hepatocellular failure is reported. Massive macro- and micro-vesicular hepatic steatosis was diagnosed at autopsy. The authors review the clinico-pathological features associated with this condition, and causal factors possibly implicated in this case are discussed in regard with currently considered pathophysiological mechanisms. [less ▲]

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See detailUse of recombinant human erythropoietin after allogeneic bone marrow transplantation
Hermanne, J.-P.; Beguin, Yves ULg

in Erythropoiesis (1997), 8

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See detailCompte rendu de Moines et religieux au Moyen Age, éd. BERLIOZ (J.), Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailFibres alimentaires chez le chien III. Effets sur les structures intestinales et les fermentations. Applications dans le traitement de certains dysfonctionnements intestinaux
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

Dietary fibres can modify the intestinal structure in dogs and other animal species. The main changes concern not only the morphology of the gastrointestinal tract but also the ultrastructures ... [more ▼]

Dietary fibres can modify the intestinal structure in dogs and other animal species. The main changes concern not only the morphology of the gastrointestinal tract but also the ultrastructures. Furthermore, soluble and partly-soluble fibres are fermented in the large bowel; the fermentation products have different metabolic effects. The physical and chemical properties of fibres can be used for the dietary therapy of some intestinal pathologies [less ▲]

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See detailEtude histologique de lésions subcliniques de la lèvre latérale du talus chez le cheval
Yousfi, S.; Gabriel, Annick ULg; Maroit, V. et al

in Annales de Médecine Vétérinaire (1997), 141

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