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See detailDetection of bone sialoprotein in human (pre)neoplastic lesions of the uterine cervix
Detry, Cédric ULg; Waltregny, David ULg; Quatresooz, Pascale ULg et al

in Calcified Tissue International (2003), 73(1), 9-14

Bone sialoprotein (BSP) is a secreted glycoprotein primarily found in the mineral compartment of developing bones. BSP is detected in a variety of human cancers, particularly those that metastasize to the ... [more ▼]

Bone sialoprotein (BSP) is a secreted glycoprotein primarily found in the mineral compartment of developing bones. BSP is detected in a variety of human cancers, particularly those that metastasize to the skeleton. High expression of BSP in breast and prostate primary carcinomas is associated with progression and bone metastases development. Since squamous cell carcinoma (SCCs) of the uterine cervix also frequently metastasizes to bone, we investigated whether BSP is expressed in human cervical cancer. We examined BSP expression in cervical tissue samples from 47 patients, including 19 normal tissues, 20 squamous intraepithelial lesions (SILs) (9 low and 11 high grade) and 8 invasive SCCs. BSP protein expression was evaluated by the immunophosphatase technique using a BSP polyclonal antibody in paraffin-embedded cervical biopsies. The abundance of BSP protein was significantly higher in invasive SCCs and high grade SILs than in normal cervix tissue samples and low grade SILs, which showed no or a low level of anti-BSP immunoreactivity. In situ hybridization experiments performed on representative cervix invasive SCCs frozen sections revealed that BSP transcripts were detectable in these lesions. Our study demonstrates that BSP expression is a common feature in high grade SILs and invasive SCCs of the uterine cervix. The prognostic value of BSP detection in these lesions and the potential role of BSP as an angiogenic factor in this type of cancer are currently under investigation. [less ▲]

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See detailFactors predictive of nephropathy in DCCT Type 1 diabetic patients with good or poor metabolic control
Zhang, Liying; Krzentowski, Georges; Albert, Adelin ULg et al

in Diabetic Medicine : A Journal of the British Diabetic Association (2003), 20(7), 580-585

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic ... [more ▼]

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic patients with either good or poor metabolic control (MC). Methods Based on material from the Diabetes Control and Complications Trial study (n = 1441), patients were considered as under good or poor MC if their HbA(1c) mean level up to last visit fell in the lowest (less than or equal to 6.9%) or highest (greater than or equal to 9.5%) quintile of the overall HbA(1c) distribution, respectively. Prevalence cases of nephropathy were excluded from the study. Survival analysis and Cox regression were applied to the data. Results Among patients with good MC (n = 277), 15% had developed nephropathy at the end of the study. Conversely, among patients with poor MC (n = 268), the proportion without the complication was 52%. When adjusting for MC, time to diabetic nephropathy was related to age (P < 0.0001), AER (P < 0.001), duration of diabetes (P < 0.005), body mass index (BMI) (P < 0.005), all at baseline, and to gender (P < 0.01). Patients with upper normal range AER levels, longer duration of diabetes and lower BMI were at higher risk, regardless of MC. The adverse effect of younger age on diabetic nephropathy was more marked in good than in poor MC. Although women tended to develop the complication more often under good MC, they appeared to be better protected under poor MC. Conclusions This study confirms occurrence of diabetic nephropathy under good MC and non-occurrence of the complication despite poor MC. It also demonstrates that some baseline covariates can affect, in a differential manner, time to diabetic nephropathy depending on MC. [less ▲]

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See detailImplicit learning of complex information in amnesia
Meulemans, Thierry ULg; Van der Linden, Martial ULg

in Brain & Cognition (2003), 52(2), 250-257

Implicit learning abilities of nine amnesic patients were explored by using an artificial grammar learning task in which the test strings were constructed in such a way that grammaticality judgments could ... [more ▼]

Implicit learning abilities of nine amnesic patients were explored by using an artificial grammar learning task in which the test strings were constructed in such a way that grammaticality judgments could not be based on a simple knowledge of bigrams and trigrams (chunks). Results show that amnesic patients and controls performed at the same level during the classification task, whereas amnesic patients performed worse than controls in an explicit generation task. Moreover, there was no correlation between the implicit and explicit measures. These results are compatible with the existence of two kinds of representation intervening in artificial grammar learning. The first one based on processes leading to fragment-specific knowledge (the chunks, which can be accessed explicitly), and the second based on the learning of simple associations and more complex conditional relations between elements. (C) 2003 Elsevier Science (USA). All rights reserved. [less ▲]

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See detailDébattre de l'intégration en France et en Belgique
Jamin, Jérôme ULg

in Hommes & Migrations (2003), 1244

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See detailNF-kappa B2/p100 induces Bcl-2 expression
Viatour, Patrick ULg; Bentires-Alj, Mohamed; Chariot, Alain ULg et al

in Leukemia (2003), 17(7), 1349-1356

The NF-kappaB2/p100 and bcl-3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas, and nuclear factor kappaB (NF-kappaB) protects ... [more ▼]

The NF-kappaB2/p100 and bcl-3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas, and nuclear factor kappaB (NF-kappaB) protects cancer cells against apoptosis. Therefore, we investigated whether this transcription factor could modulate the expression of the Bcl-2 antiapoptotic protein. Bcl-2 promoter analysis showed multiple putative NF-kappaB binding sites. Transfection assays of bcl-2 promoter constructs in HCT116 cells showed that NF-kappaB can indeed transactivate bcl-2. We identified a kappaB site located at position -180 that can only be bound and transactivated by p50 or p52 homodimers. As p50 and p52 homodimers are devoid of any transactivating domains, we showed that they can transactivate the bcl-2 promoter through association with Bcl-3. We also observed that stable overexpression of p100 and its processed product p52 can induce endogenous Bcl-2 expression in MCF7AZ breast cancer cells. Finally, we demonstrated that, in breast cancer and leukemic cells ( CLL), high NF-kappaB2/p100 expression was associated with high Bcl-2 expression. Our data suggest that Bcl-2 could be an in vivo target gene for NF-kappaB2/p100. [less ▲]

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See detailConventional abdominal aortic aneurysm repair: Evidence-based assessment
Limet, Raymond ULg

in Annals of Vascular Surgery (2003), 17(4), 349-353

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See detailRecognition and implication of tectonic loading-induced reheating in the northern Variscan front (Belgium and northern France), based on an illite Kubler index and oxygen isotope study
Han, G.; Yans, J.; Goudalier, M. et al

in International Journal of Earth Sciences (2003), 92(3), 348-363

Illite Kubler index (KI) and oxygen isotope (brachiopods and micrites) investigations have been performed on more than 300 Frasnian limestones sampled in one borehole and numerous outcrops in the Dinant ... [more ▼]

Illite Kubler index (KI) and oxygen isotope (brachiopods and micrites) investigations have been performed on more than 300 Frasnian limestones sampled in one borehole and numerous outcrops in the Dinant Synclinorium (Belgium, northern France) of the northern Variscan front. The illite Kubler index and delta(18)O data of a 3-km-thick, tectonically repeated Frasnian series from the Focant borehole are compared with their surrounding surface correspondents and document in-situ reheating induced by Variscan tectonic loading, which post-dated sedimentary burial alteration. The boundary between these two thermal processes (sedimentary burial and tectonic loading) on the Focant profile corresponds to an important location where the heat induced by the tectonic loading was equivalent to that Frasnian strata suffered during maximum sedimentary burial. Mainly based on this knowledge and on a former conodont colour alteration index study, the thickness of the eroded thrust sheet in the Focant area is estimated to be around 3,000 m. Oxygen isotopic exchange in these Frasnian closed carbonate systems, occurring under highest-grade diagenesis and anchimetamorphism, records two events. Brachiopods present a quite different and more homogeneous pattern, due to their higher resistance to heat alteration. These thermal events caused both delta(18)O records to become increasingly lighter than the presumed original seawater signature. The comparison between KI and delta(18)O profiles indicates that illite KI analysis is more appropriate than delta(18)O in highlighting the temperature variations in the burial metamorphism at the periphery of orogenic belts. [less ▲]

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See detailThe effects of happy and angry expressions on identity and expression memory for unfamiliar faces
D'Argembeau, Arnaud ULg; Van der Linden, Martial ULg; Comblain, Christine et al

in Cognition & Emotion (2003), 17(4), 609-622

We investigated the influence of happy and angry expressions on memory for new faces. Participants were presented with happy and angry faces in an intentional or incidental learning condition and were ... [more ▼]

We investigated the influence of happy and angry expressions on memory for new faces. Participants were presented with happy and angry faces in an intentional or incidental learning condition and were later asked to recognise the same faces displaying a neutral expression. They also had to remember what the initial expressions of the faces had been. Remember/know/guess judgements were made both for identity and expression memory. Results showed that faces were better recognised when presented with a happy rather than an angry expression, but only when learning was intentional. This was mainly due to an increase of the I remember" responses for happy faces when encoding was intentional rather than incidental. In contrast, memory for emotional expressions was not different for happy and angry faces whatever the encoding conditions. We interpret these findings according to the social meaning of emotional expressions for the self. [less ▲]

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See detailCold adaptation of a psychrophilic chitinase: a mutagenesis study
Mavromatis, K.; Feller, Georges ULg; Kokkinidis, M. et al

in Protein Engineering (2003), 16(7), 497-503

The gene encoding chitinase ArChiB from the Antarctic Arthrobacter sp. TAD20 has been expressed in Escherichia coli and the recombinant enzyme purified to homogeneity. In an effort to engineer cold ... [more ▼]

The gene encoding chitinase ArChiB from the Antarctic Arthrobacter sp. TAD20 has been expressed in Escherichia coli and the recombinant enzyme purified to homogeneity. In an effort to engineer cold-adapted biocatalysts through rational redesign to operate at elevated temperatures, we performed several mutations aiming to increase the rigidity of the molecular edifice of the selected psychrophilic chitinase. The mutations were designed on the basis of a homology-based three-dimensional model of the enzyme, and included an attempt to introduce a salt bridge (mutant N198K) and replacements of selected Gly residues by either Pro (mutants G93P, G254P) or Gln (G406Q). Mutant N198K resulted in a more stable protein (DeltaT(m)=0.6degreesC). Mutant G93P exhibited a DeltaT(m) of 1.2degreesC, while mutants G254P and G406Q exhibited decreased stability. We conclude that the effect of mutating Gly residues on enzyme stability is rather complex and can only be understood in the context of the structural environment. Kinetic and spectroscopic analysis of these enzyme variants revealed that the kinetic parameters k(cat) and K-m have been significantly modified. [less ▲]

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See detailÀ quel âge est-on prêt à voter ? La participation des jeunes à la vie collective
Hudon, Raymond; Fournier, Bernard ULg

in Perspectives électorales/Electoral Insight (2003), 5(2), 36-41

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See detailSynthesis and activity of another seleniated auxin: 2,4-dichlorophenylselenoacetic acid
Tadino, Vincent; Faez, Juan Mareque; Christiaens, Léon ULg et al

in Plant Growth Regulation (2003), 40(3), 197-200

The synthesis of 2,4-dichlorophenylselenoacetic acid (2,4-D-Se) may be completed in three steps starting from 2,4-dichloroaniline. The selenium is inserted in the molecule by reaction of a diazonium salt ... [more ▼]

The synthesis of 2,4-dichlorophenylselenoacetic acid (2,4-D-Se) may be completed in three steps starting from 2,4-dichloroaniline. The selenium is inserted in the molecule by reaction of a diazonium salt with potassium selenocyanate. 2,4-D-Se has been tested as an auxin in several bioassays including the regeneration of somatic embryos, adventitious root formation and the associated temporary increase of endogenous auxins at the induction phase, and callus formation, and compared with the natural auxin indoleacetic acid (IAA), the classical synthetic auxin(s) naphthaleneacetic acid (NAA) and/or 2,4-dichlorophenoxyacetic acid (2,4-D), and with the synthetic seleniated IAA, 3-(benzo[b] selenienyl) acetic acid, BSAA. These biological assays classified 2,4-D-Se together with BSAA among the most powerful synthetic auxins. The role of selenium is briefly discussed. [less ▲]

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See detailSocial insurance competition between Bismarck and Beveridge
Cremer, H.; Pestieau, Pierre ULg

in Journal of Urban Economics (2003), 54(1), 181-196

Social insurance schemes differ according to the relationship between contributions and benefits. Bismarckian systems provide earnings-related benefits, while Beveridgean systems offer flat payments. The ... [more ▼]

Social insurance schemes differ according to the relationship between contributions and benefits. Bismarckian systems provide earnings-related benefits, while Beveridgean systems offer flat payments. The conventional wisdom is that with factor mobility poor people have incentives to move towards Beveridgean countries. Consequently, Beveridgean regimes would not be sustainable under economic integration. This paper studies the validity of such a conjecture within a simple model. It is shown that mobility does have a significant impact on social protection. However, the equilibrium patterns that can emerge are more complex and diversified than the initial conjecture suggests. In some cases, the equilibrium may even imply that all the poor move to the Bismarckian country. (C) 2003 Elsevier Inc. All rights reserved. [less ▲]

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See detailTourner la page des convergences à gauche
Jacquemain, Marc ULg

in Politique : Revue de Débats (2003), 30

Analyse de la nouvelle conjoncture politique qui conduit à la défaite écologiste et au succès socialiste en 2003 : les socialistes ont davantage bénéficié de "l'alliance privilégiée" avec les écologistes ... [more ▼]

Analyse de la nouvelle conjoncture politique qui conduit à la défaite écologiste et au succès socialiste en 2003 : les socialistes ont davantage bénéficié de "l'alliance privilégiée" avec les écologistes que leur "junior partner" qui faisait sa première expérience gouvernementale. Mais en affaiblissant son probable meilleur partenaire en Belgique francophone, le PS a peut-être manoeuvré à courte vue pour des alliances futures. [less ▲]

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See detailHow Old Is Old Enough to Vote. Youth Participation in Society
Hudon, Raymond; Fournier, Bernard ULg

in Perspectives électorales/Electoral Insight (2003), 5(2), 38-43

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See detailPlacental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
Rakic, Jean-Marie ULg; Lambert, Vincent ULg; Devy, Laetitia et al

in Investigative Ophthalmology & Visual Science (2003), 44(7), 3186-3193

PURPOSE. VEGF has been shown to be necessary, but not sufficient alone, for the development of subretinal pathologic angiogenesis. In the current study, the influence of placental growth factor (PIGF), a ... [more ▼]

PURPOSE. VEGF has been shown to be necessary, but not sufficient alone, for the development of subretinal pathologic angiogenesis. In the current study, the influence of placental growth factor (PIGF), a member of the VEGF family, in human and experimental choroidal neovascularization (CNV) was investigated. METHODS. The presence of VEGF family member mRNA was evaluated by RT-PCR in neovascular membranes extracted during surgery. The spatial and temporal pattern of VEGF isoforms and PIGF mRNA expression were explored by using the laser capture catapulting technique and RT-PCR in a murine laser-induced model and in vitro. PIGF expression was also studied in human donor eyes. The influence of endogenous PIGF was evaluated in deficient mice (PlGF(-/-)) and by antibody-mediated neutralization of the PIGF receptor. RESULTS. Human neovascular membranes consistently expressed VEGF-A, -B, and -C; PlGF; and VEGFR-1 and -2. The VEGF(120) isoform mRNA was primarily induced in early stages of angiogenesis in vivo and in vitro. PIGF mRNA expression was present in the intact choroid and significantly upregulated during the course of experimental CNV. Both deficient PIGF expression in PIGF(-/-) mice and PIGF receptor neutralization in wild-type mice prevented the development of choroidal neovascularization induced by laser. CONCLUSIONS. These observations demonstrate the participation of PIGF in experimental CNV. They identify therefore PIGF as an additional promising target for ocular antiangiogenic strategies. [less ▲]

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See detailA pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations
Messin, R.; Fenyvesi, T.; Carreer-Bruhwyler, F. et al

in European Journal of Clinical Pharmacology (2003), 59(3), 227-232

Objectives. A new once-a-day (o.a.d.) formulation of molsidomine (16 mg) was evaluated in patients with stable angina pectoris. The aims were to characterize its pharmacokinetics after a single dose, to ... [more ▼]

Objectives. A new once-a-day (o.a.d.) formulation of molsidomine (16 mg) was evaluated in patients with stable angina pectoris. The aims were to characterize its pharmacokinetics after a single dose, to demonstrate its clinical efficacy and safety versus placebo and to investigate correlations between pharmacokinetics and pharmacodynamics. Methods. Forty-two patients were recruited in a double-blind, crossover, randomized placebo-controlled trial. The pharmacokinetics of molsidomine and SIN-1, its active metabolite, were determined at specific time points (3, 6, 10, 14, 18, 22 and 24 h) after the administration of a single dose of molsidomine 16 mg o.a.d. in all patients distributed into seven groups. Twenty-eight of these 42 patients showed a positive baseline cycloergometric exercise test response during the run-in placebo period and were used to compare the efficacy of molsidomine to placebo. Relationships between plasma concentration in molsidomine or SIN-1 and ischemic threshold were assessed in 16 of the 28 patients with a positive exercise test at baseline. Indeed, the censored variable ischemia-limited tolerance to exercise could not be evaluated in those patients who did not show exercise-induced ischemia anymore under molsidomine 16 mg o.a.d. Pharmacokinetic-pharmacodynamic relationships were evaluated using regression models and correlation coefficients. Results. The highest average concentration in molsidomine and SIN-1 occurred after 6 h, then a plateau of 15-20 ng/ml molsidomine and 0.8-3.0 ng/ml SIN-1 was maintained for at least 8 h and the mean residual molsidomine concentration 24 h post-drug intake was around 8 ng/ml, still in the effective range of 5-10 ng/ml. A significant increase in total workload (+52 W min, P=0.009), total exercise time (+32 s, P=0.003) and time to angina (+25 s, P=0.016) was measured with molsidomine 16 mg o.a.d. relative to placebo. Using linear regression, significant correlation coefficients were determined between molsidomine plasma concentrations (but not SIN-1) and exercise test improvements (r=0.827, P<0.001 for the total workload; r=0.772, P<0.001 for the total exercise time; and r=0.566, P=0.028 for the time to 1 mm ST-segment depression). Conclusion. The pharmacokinetics of molsidomine 16 mg in patients with stable angina pectoris is compatible with a o.a.d. dosage regimen. This o.a.d. formulation is effective and well-tolerated, providing a 24-h therapeutic control of myocardial ischemia. A positive and significant linear relationship between molsidomine plasma concentration and the increase in exercise tolerance was observed. [less ▲]

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See detailSurvey of commercial pasteurised cows' milk in Wallonia (Belgium) for the occurrence of polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls
Focant, Jean-François ULg; Pirard, Catherine ULg; Massart, Anne-Cécile ULg et al

in Chemosphere (2003), 52(4), 725-733

Congener-specific analyses of 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs) and 4 non-ortho (coplanar) polychlorinated biphenyls (cPCBs) were performed on 35 ... [more ▼]

Congener-specific analyses of 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs) and 4 non-ortho (coplanar) polychlorinated biphenyls (cPCBs) were performed on 35 samples of commercial long-life pasteurised cows' milk issued from eight different brands available in Walloon supermarkets (Belgium). The observed congener profile was characteristic of milk samples issued from industrialised countries with good inter and intra-brand reproducibility's. The PCDDs to PCDFs ratio was equal to 1.8 in concentration. The toxic equivalent (TEQ based on WHO-TEF) value for PCDD/Fs in all analysed milks was 1.09+/-0.30 pg TEQ/g fat (range 0.86-1.59), which is below the recommended EU non-commercialisation threshold value of 3 pg TEQ PCDD/Fs/g of milk fat. The mean TEQ value including cPCBs was 2.23+/-0.55 pg TEQ/g fat. These PCBs actually contributed for 49+/-8.6% of the total TEQ. Among PCDD/Fs and cPCBs, tetrachloro dibenzo-p-dioxin (TCDD), pentachloro dibenzo-p-dioxin (PeCDD), pentachloro dibenzofurans (PeCDFs) and 3,3',4,4',5-pentachloro biphenyl (PCB-126) were the most important contributors to the TEQ. Estimated daily intake (EDI) due to consumption of such milks was 0.34 pg TEQ/kg of body weight/day for PCDD/Fs and 0.69 pg TEQ/kg of body weight/day when cPCBs were included. [less ▲]

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See detailIncreased cerebral functional connectivity underlying the antinociceptive effects of hypnosis
Faymonville, Marie-Elisabeth ULg; Roediger, Laurence ULg; Del Fiore, Guy et al

in Cognitive Brain Research (2003), 17(2), 255-262

The neural mechanisms underlying the antinociceptive effects of hypnosis are not well understood. Using positron emission tomography (PET), we recently showed that the activity in the anterior cingulate ... [more ▼]

The neural mechanisms underlying the antinociceptive effects of hypnosis are not well understood. Using positron emission tomography (PET), we recently showed that the activity in the anterior cingulate cortex (midcingulate area 24a') covaries with the hypnosis-induced reduction of affective and sensory responses to noxious thermal stimulation [Faymonville et al., Anesthesiology 92 (2000) 1257-1267]. In the present study, we assessed changes in cerebral functional connectivity related to the hypnotic state, compared to simple distraction and the resting state. Nineteen highly hypnotizable right-handed volunteers were studied using (H2O)-O-15-PET. The experimental conditions were hot noxious or warm non-noxious stimulation of the right hand during resting state, mental imagery and hypnotic state. Using a psychophysiological interaction analysis, we identified brain areas that would respond to noxious stimulations under the modulatory action of the midcingulate cortex in, and only in, the hypnotic state. Hypnosis, compared to the resting state, reduced pain perception by 50%. Pain perception during rest and mental imagery was not significantly different. Analysis of PET data showed that the hypnotic state, compared to normal alertness (i.e., rest and mental imagery), significantly enhanced the functional modulation between midcingulate cortex and a large neural network encompassing bilateral insula, pregenual anterior cingulate cortex, pre-supplementary motor area, right prefrontal cortex and striatum, thalamus and brainstem. These findings point to a critical role for the midcingulate cortex in the modulation of a large cortical and subcortical network underlying its influence on sensory, affective, Cognitive and behavioral aspects of nociception, in the specific context of hypnosis. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailBulletin agrométéorologique - Juin 2003
Tychon, Bernard ULg; Ozer, P.; Eerens, H. et al

in Bulletin Agrométéorologique (2003)

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See detailInitiation of earthquake-induced slope failure: influence of topographical and other site specific amplification effects
Havenith, Hans-Balder ULg; Vanini, M.; Jongmans, D. et al

in Journal of Seismology (2003), 7(3), 397-412

Increased structural damage caused by earthquakes on hilltops and along ridges has often been related to amplification of ground motion due to the presence of topography. However, comparison between ... [more ▼]

Increased structural damage caused by earthquakes on hilltops and along ridges has often been related to amplification of ground motion due to the presence of topography. However, comparison between observations and numerical modeling has shown that amplification is only partly dependent on the prominent surface morphology. Strong effects are also induced by soft layers, such as weathered rock material or colluvium, covering the topographies. Numerous seismically triggered landslides are reported to occur in the same materials that are likely to amplify ground motions. Therefore, it can be suspected that ground motion dynamics significantly contribute to the observed slopes failures. This potential relationship is the subject of the present case study, the Ananevo rockslide in the northeastern Tien Shan mountains. The survey included geophysical prospecting, earthquake recordings and structural analyses of the rock fabric. On the basis of the field data, observed amplification effects could be related to the local geological conditions and particularly to the surface morphology and to the presence of low-velocity layers-deeply weathered rocks-on the top of the bedrock. Surface layer- and topography-dependent amplification has also been studied numerically by 2D and 3D finite element modeling of ground motion dynamics. The present paper focuses on additional effects that may be induced by the presence of a fault zone and of the landslide scarp. Further, observed and computed ground motion dynamics are connected with slope failure susceptibility: 2D numerical simulations reveal that strain localization is closely related to wave amplification in surficial low-velocity layers, particularly below convex surface morphologies. [less ▲]

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See detailLC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design
Marini Djang'Eing'A, Roland ULg; Chiap, Patrice ULg; Boulanger, Bruno ULg et al

in Journal of Separation Science (2003), 26(9-10), 809-817

A liquid chromatography (LC) method using cellulose tris(3,5-dimethylphenylcarbamate) (5 mum) as chiral stationary phase (CSP) and a mixture of hexane, 2-propanol, and diethylamine as mobile phase was ... [more ▼]

A liquid chromatography (LC) method using cellulose tris(3,5-dimethylphenylcarbamate) (5 mum) as chiral stationary phase (CSP) and a mixture of hexane, 2-propanol, and diethylamine as mobile phase was developed for the simultaneous determination of R-timolol and other potential related substances in S-timolol maleate samples. An experimental design was elaborated in order to test the effects of the different selected factors. Three factors were studied simultaneously, namely the concentrations of 2-propanol and diethylamine as well as the column temperature. The effects of these factors were evaluated statistically. Optimal LC conditions were then deduced by applying a multicriteria decision making approach, namely Derringer's desirability function, for the responses of interest. The developed LC method was compared to the European Pharmacopoeia method and was applied to the determination of R-timolol and other related substances in several samples of S-timolol maleate from different sources. [less ▲]

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See detailLe cadre légal de la médiation victime-auteur en Europe continentale
Lauwaert, Katrien ULg

in Le Journal International de Victimologie (2003), (4),

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See detailOligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia
Bergmann, C.; Zerres, K.; Senderek, J. et al

in Brain (2003), 126(7), 1537-1544

We identified an oligophrenin 1 (OPHN1) gene mutation in a family with five brothers affected by a recognizable pattern of clinical and neuroradiological hallmarks. The distinctive phenotype comprised ... [more ▼]

We identified an oligophrenin 1 (OPHN1) gene mutation in a family with five brothers affected by a recognizable pattern of clinical and neuroradiological hallmarks. The distinctive phenotype comprised moderate to severe mental retardation, myoclonic-astatic epilepsy, ataxia, strabismus and hypogenitalism. Neuroimaging displayed fronto-temporal atrophy with rostral enlargement of the lateral ventricles, lower vermian agenesis and asymmetric cerebellar hypoplasia. Mutation analysis of the OPHN1 gene on Xq12 disclosed a genomic deletion of exon 19 causing a frameshift. Notably, OPHN1 mutations have been previously reported as a rare cause of non-syndromic X-linked mental retardation. Our findings, however, indicate that OPHN1 mutations result in a recognizable syndrome. In addition, identification of OPHN1 as a further gene associated with epileptic seizures will help to unravel aetiologic factors of epilepsy. [less ▲]

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See detailPhonological short-term memory networks following recovery from Landau and Kleffner syndrome
Majerus, Steve ULg; Laureys, Steven ULg; Collette, Fabienne ULg et al

in Human Brain Mapping (2003), 19(3), 133-144

Landau-Kleffner syndrome (LKS) is a rare acquired aphasia occurring in otherwise healthy children, together with spike-wave discharges predominating over superior temporal regions and activated by sleep ... [more ▼]

Landau-Kleffner syndrome (LKS) is a rare acquired aphasia occurring in otherwise healthy children, together with spike-wave discharges predominating over superior temporal regions and activated by sleep. Although the outcome of language abilities is variable, a residual impairment in verbal short-term memory (STM) is frequent. This STM deficit might be related to the persistent dysfunction of those temporal lobe regions where epileptic discharges were observed during the active phase of the disorder. We tested this hypothesis by measuring brain activation during immediate serial recall of lists of 4 words, compared to single word repetition, using H(2) (15)O positron emission tomography (PET), in 3 LKS patients after recovery and in 14 healthy controls. The patients (TG, JPH, and DC) had shown abnormally increased or decreased glucose metabolism in left or right superior temporal gyrus (STG) at different stages during the active phase of their disease. At the time of this study, the patients were 6-10 years from the active phase of LKS. Results showed that Patients JPH and DC had impaired performance in the STM condition, whereas TG showed near normal performance. PET data showed that JPH and DC activated significantly less than controls left and right posterior STG. TG, having near normal STM performance, showed increased activity in the posterior part of the right STG. These data suggest that impaired verbal STM at late outcome of LKS might indeed be related to a persistent decrease of activity in those posterior superior temporal gyri that were involved in the epileptic focus during the active phase. [less ▲]

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See detailAdditive functions with respect to numeration systems on regular languages
Grabner, Peter J.; Rigo, Michel ULg

in Monatshefte fur Mathematik (2003), 139(3), 205-219

Asymptotic formulae for the summatory function of additive arithmetic functions related to numeration systems given by regular languages are derived.

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See detailBM-573, a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, prevents pig myocardial infarction induced by coronary thrombosis
Rolin, S.; Petein, M.; Tchana-Sato, Vincent ULg et al

in Journal of Pharmacology and Experimental therapeutics (2003), 306(1), 59-65

The aim of this study was to characterize the effects of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a novel dual thromboxane A 2 receptor antagonist and thromboxane ... [more ▼]

The aim of this study was to characterize the effects of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a novel dual thromboxane A 2 receptor antagonist and thromboxane synthase inhibitor, on myocardial infarction induced by topical ferric chloride (FeCl3) application to the left anterior descending (LAD) coronary artery in anesthetized pigs. All control animals (n = 6) developed an occlusive thrombus in the LAD coronary artery. The mean infarct size, revealed by triphenyl tetrazolium chloride (TTC), and the area at risk, evidenced by Evans blue, corresponded to 35.3 +/- 2.2 and 36.9 +/- 2.1% of the left ventricular mass, respectively. In the BM-573-treated group (n = 6), a drug infusion (10 mg . kg(-1) . h(-1)) started 30 min before FeCl3 application and continued throughout the experimentation. Among the BM-573-treated group, four pigs did not develop coronary artery thrombus and their myocardium appeared healthy. Histopathological examination of FeCl3-injured coronary artery revealed an occlusive and adherent thrombus in control group, while pretreatment with BM-573 prevented thrombus formation. In infarcted zones, lack of desmin staining and muscle structure disorganization were obvious. Depletion of myocardial ATP content was observed in the myocardial necrotic region of the control group, but not in myocardial samples of BM-573-treated pigs that did not develop myocardial infarction. When BM-573 prevented LAD artery occlusion, the area under the curve of plasmatic troponin T was reduced by 77% over 6 h. These data suggest that BM-573 could be useful for the prevention of myocardial infarction. [less ▲]

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See detailLimit current density in 2D metallic granular packings
Dorbolo, Stéphane ULg; Ausloos, Marcel ULg; Vandewalle, Nicolas ULg

in European Physical Journal B -- Condensed Matter (2003), 34(2), 201-204

The electrical properties of a 2D packed metallic pentagons have been studied. The electrical characterization of such metallic pentagon heaps, like i - V measurements, has been achieved. Two distinct ... [more ▼]

The electrical properties of a 2D packed metallic pentagons have been studied. The electrical characterization of such metallic pentagon heaps, like i - V measurements, has been achieved. Two distinct regimes have been shown. They are separated by a transition line along which the system exhibits a memory effect behavior due to the irreversible improvement of electrical contacts between pentagons (hot spots). A limit current density has been found. [less ▲]

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See detailPost-stroke reorganization of hand motor area : a 1-year prospective follow-up with focal transcranial magnetic stimulation
DELVAUX, Valérie ULg; Alagona, Giovanna; GERARD, Pascale ULg et al

in Clinical Neurophysiology (2003), 114(Issue 4), 1217-1225

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See detailEffects of U-46619 on Pulmonary Hemodynamics before and after Administration of Bm-573, a Novel Thromboxane A2 Inhibitor
Lambermont, Bernard ULg; Kolh, Philippe ULg; Dogné, Jean-Michel ULg et al

in Archives of Physiology & Biochemistry (2003), 111(3), 217-23

We studied the effects on pulmonary hemodynamics of U-46619, a thromboxane A2 (TXA2) agonist, before and after administration of a novel TXA2 receptor antagonist and synthase inhibitor (BM-573). Six ... [more ▼]

We studied the effects on pulmonary hemodynamics of U-46619, a thromboxane A2 (TXA2) agonist, before and after administration of a novel TXA2 receptor antagonist and synthase inhibitor (BM-573). Six anesthetized pigs (Ago group) received 6 consecutive injections of U-46619 at 30-min interval and were compared with six anesthetized pigs (Anta group) which received an increasing dosage regimen of BM-573 10 min before each U-46619 injection. Consecutive changes in pulmonary hemodynamics, including characteristic resistance, vascular compliance, and peripheral vascular resistance, were continuously assessed during the experimental protocol using a four-element Windkessel model. At 2 mg/kg, BM-573 completely blocked pulmonary hypertensive effects of U-46619 but pulmonary vascular compliance still decreased. This residual effect can probably be explained by a persistent increase in the tonus of the pulmonary vascular wall smooth muscles sufficient to decrease vascular compliance but not vessel lumen diameter. Such molecule could be a promising therapeutic approach in TXA2 mediated pulmonary hypertension as it is the case in pulmonary embolism, hyperacute lung rejection and endotoxinic shock. [less ▲]

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See detailThe massive binary CPD-41°7742 - I. High-resolution optical spectroscopy
Sana, H.; Hensberge, H.; Rauw, Grégor ULg et al

in Astronomy and Astrophysics (2003), 405(3), 1063-1074

We present the results of a spectroscopic campaign on the early-type binary CPD-41degrees 7742. For the first time, we unambiguously detect the secondary's spectral signature and derive an accurate ... [more ▼]

We present the results of a spectroscopic campaign on the early-type binary CPD-41degrees 7742. For the first time, we unambiguously detect the secondary's spectral signature and derive an accurate orbital solution for both components of the system. We confirm that the orbit displays a slight but definite eccentricity (e=0.027+/-0.006) despite the short period (P=2.44070+/-0.00043 days). Previous radial velocity measurements available in the literature constitute together with our new observations a data set that spans more than 30 years. The combined primary orbital solution inferred is in excellent agreement with our solution and gives a period P=2.44062+/-0.00005 days. Based on spectroscopic criteria, we derive a spectral and luminosity classification of O9 III + B1 III. However, the luminosities and radii inferred from the membership of NGC6231 rather indicate lower luminosity classes. We show that the equivalent widths of well isolated primary lines display variations that suggest that CPD-41degrees 7742 is an eclipsing binary. This makes CPD-41degrees 7742 the second known SB2 eclipsing early-type binary of the NGC 6231 cluster. We approximately constrain the inclination of the system i(min) approximate to 60degrees. This may indicate that the system does not offer enough room for two stars with radii typical of giant stars and lends further support to a less evolved luminosity classification for at least one of the objects. [less ▲]

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See detailBayesian model screening for the identification of nonlinear mechanical structures
Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg; Hemez, F. M.

in Journal of Vibration and Acoustics-Transactions of the Asme (2003), 125(3), 389-397

The development of techniques for identification and updating of nonlinear mechanical structures has received increasing attention in recent years. In practical situations, there is not necessarily a ... [more ▼]

The development of techniques for identification and updating of nonlinear mechanical structures has received increasing attention in recent years. In practical situations, there is not necessarily a priori knowledge about the nonlinearity. This suggests the need for strategies that allow inference of useful information from the data. The present study proposes an algorithm based on a Bayesian inference approach for giving insight into the form of the nonlinearity. A family of parametric models is defined to represent the nonlinear response of a system and the selection algorithm estimates the likelihood that each member of the family is appropriate. The (unknown) probability density function of the family of models is explored using a simple variant of the Markov Chain Monte Carlo sampling technique. This technique offers the advantage that the nature of the underlying statistical distribution need not be assumed a priori. Enough samples are drawn to guarantee that the empirical distribution approximates the true but unknown distribution to the desired level of accuracy. It provides an indication of which models are the most appropriate to represent the nonlinearity and their respective goodness-of-fit to the data. The methodology is illustrated using two examples, one of which comes from experimental data. [less ▲]

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See detailExpression, purification, crystallization and preliminary X-ray crystallographic studies of a psychrophilic cellulase from Pseudoalteromonas haloplanktis
Violot, S.; Haser, R.; Sonan, G. et al

in Acta Crystallographica Section D-Biological Crystallography (2003), 59(Part 7), 1256-1258

The Antarctic psychrophile Pseudoalteromonas haloplanktis produces a cold-active cellulase. To date, a three-dimensional structure of a psychrophilic cellulase has been lacking. Crystallographic studies ... [more ▼]

The Antarctic psychrophile Pseudoalteromonas haloplanktis produces a cold-active cellulase. To date, a three-dimensional structure of a psychrophilic cellulase has been lacking. Crystallographic studies of this cold-adapted enzyme have therefore been initiated in order to contribute to the understanding of the molecular basis of the cold adaptation and the high catalytic efficiency of the enzyme at low and moderate temperatures. The catalytic core domain of the psychrophilic cellulase CelG from P. haloplanktis has been expressed, purified and crystallized and a complete diffraction data set to 1.8 Angstrom has been collected. The space group was found to be P2(1)2(1)2(1), with unit-cell parameters a = 135.1, b = 78.4, c = 44.1 Angstrom. A molecular-replacement solution, using the structure of the mesophilic counterpart Cel5A from Erwinia chrysanthemi as a search model, has been found. [less ▲]

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See detailThe 1.5-angstrom structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, D-captopril
Garcia-Saez, I.; Hopkins, J.; Papamicael, C. et al

in Journal of Biological Chemistry (2003), 278(26), 23868-23873

The crystal structure of the class-B beta-lactamase, BlaB, from the pathogenic bacterium, Chryseobacterium meningosepticum, in complex with the inhibitor, D-captopril, has been solved at 1.5-Angstrom ... [more ▼]

The crystal structure of the class-B beta-lactamase, BlaB, from the pathogenic bacterium, Chryseobacterium meningosepticum, in complex with the inhibitor, D-captopril, has been solved at 1.5-Angstrom resolution. The enzyme has the typical alphabeta/betaalpha metallo-beta-lactamase fold and the characteristic two metal binding sites of members of the subclass B1, in which two Zn2+ ions were identified. D-Captopril, a diastereoisomer of the commercial drug, captopril, acts as an inhibitor by displacing the catalytic hydroxyl ion required for antibiotic hydrolysis and intercalating its sulfhydryl group between the two Zn2+ ions. Interestingly, D-captopril is located on one side of the active site cleft. The x-ray structure of the complex of the closely related enzyme, IMP-1, with a mercaptocarboxylate inhibitor, which also contains a sulfhydryl group bound to the two Zn2+ ions, shows the ligand to be located on the opposite side of the active site cleft. A molecule generated by fusion of these two inhibitors would cover the entire cleft, suggesting an interesting approach to the design of highly specific inhibitors. [less ▲]

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See detailExchange processes and nitrogen cycling on the shelf and continental slope of the Black Sea basin
Grégoire, Marilaure ULg; Lacroix, Geneviève

in Global Biogeochemical Cycles (2003), 17(2),

A 3D coupled biogeochemical-hydrodynamical model has been applied to the Black Sea to simulate nitrogen cycling and to estimate the exchange of biogeochemical components at the shelf break and between the ... [more ▼]

A 3D coupled biogeochemical-hydrodynamical model has been applied to the Black Sea to simulate nitrogen cycling and to estimate the exchange of biogeochemical components at the shelf break and between the continental slope and the deep sea. It was found that biological processes on the northwestern shelf are in approximate balance. Primary production is fueled by river discharge, nitrate input from the open sea at the shelf break, and in situ remineralization. The input of nitrate from the open sea is roughly equivalent to the river nitrate discharge but is half the nitrate export from the shelf toward the open sea. Also, the Black Sea shelf acts throughout the year as a nitrate source for the open sea. The amount of shelf production not remineralized in the euphotic layer is 22.2% and is exported to lower layers (20%) or offshore (2.2%). We estimate that the export of carbon from the shelf to the interior of the basin represents 2.5% of the new production of the open sea. The upper slope adjoining the northwestern shelf is the site of downwelling events responsible for the downward transport to the intermediate layer of the continental slope of biogeochemical components exported from the shelf in the upper layer. The shelf has been found to be an efficient trap for the refractory material discharged by the Danube. [less ▲]

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See detailCharacterization and dynamics of the auroral electron precipitation during substorms deduced from IMAGE-FUV
Meurant, M.; Gérard, Jean-Claude ULg; Hubert, Benoît ULg et al

in Journal of Geophysical Research. Space Physics (2003), 108(A6),

[1] The FUV imager on board the IMAGE satellite provides simultaneous images of the north polar aurora every 2 min in three spectral channels. The Wideband Imaging Camera (WIC) responds primarily to the N ... [more ▼]

[1] The FUV imager on board the IMAGE satellite provides simultaneous images of the north polar aurora every 2 min in three spectral channels. The Wideband Imaging Camera (WIC) responds primarily to the N-2 LBH bands while one of the Spectral Imagers (SI13) includes the OI 135.6 nm emission and nearby LBH bands. The third channel (SI12) is sensitive to Doppler-shifted Lyman-alpha emission at 121.8 nm generated by proton precipitation. The relative magnitude of the WIC and SI13 signals depends on the altitude distribution of the energy deposition, in response to the differential O-2 absorption and the altitude dependence of the neutral composition. The ratio of simultaneous images from WIC and SI13 is used to derive the spatial distribution of the characteristic energy of the precipitating auroral electrons and the energy flux they carry. The method is described and the uncertainties introduced by possible perturbations of the neutral composition known to occur in the auroral thermosphere are discussed. The first part of this study describes a validation of this method performed by comparing precipitation characteristics derived from FUV with in situ measurements from two coincident passes of the NOAA-16 satellite. They are shown to agree within about 45%. The second part applies this ratio method to analyze the time evolution of auroral activity which occured during two substorms on 28 October 2000. The time evolution is displayed in the form of magnetic local time and magnetic latitude keograms. It is shown that the pattern of the electron average energy distribution exhibits both spatial and temporal changes. Comparison with FAST in situ electron spectrograms confirms the ability of IMAGE to detect precipitation events with a similar to200 km spatial scale. However the characteristics of the physical process leading to electron acceleration cannot be identified with FUV. The highest values of the average energy are colocated in time and space with the largest electron precipitation fluxes. A dawnward motion of bright features is observed in the postmidnight at speeds on the order of 5 magnetic local time hours/UT hour. [less ▲]

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See detailFacilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice
Bernaerts, P.; Tirelli, Ezio ULg

in Behavioural Brain Research (2003), 142(1-2), 41-52

The still unknown contribution of the D4 receptors to memory consolidation was studied examining the memory effects of the dopamine D4 agonist PD168,077, the putative dopamine D4 antagonist L745,870 ... [more ▼]

The still unknown contribution of the D4 receptors to memory consolidation was studied examining the memory effects of the dopamine D4 agonist PD168,077, the putative dopamine D4 antagonist L745,870, their mutual combination, and the combination of the D4 agonist with representative compounds acting as agonist or antagonist on the D1, D2 and the D3 receptors. Memory consolidation was assessed in C57BL/6J mice using the one-trial step-through inhibitory avoidance task, the compounds being injected immediately after training (foot-shock) and performance measured 24h later. PD168,077 (0.5-10mg/kg) dose-dependently improved memory performance and L745,870 (0.05-5mg/kg) at doses lower than 1mg/kg increased and at doses higher than 1mg/kg impaired memory performance. PD168,077 did not affect the paradoxical promnesic effect of low doses (0.1-0.5mg/kg) of L745,870, but antagonised the memory-impairing effect induced by 5mg/kg L745,870. The D1 antagonist SCH23390 (0.025-0.05 mg/kg) and the D2 antagonist eticlopride (0.01-0.05 mg/kg) antagonised the promnesic effects of PD168,077, which attenuated the decreasing effect on memory consolidation of both D1 and D2 antagonists. Accordingly, the D1 agonist SKF38393 (5-20mg/kg) and the D2 agonist quinelorane (0.1-1 mg/kg) both synergistically magnified the memory-improving effects of the D4 agonist. The dopamine D3 antagonist U99194A (2.5-10mg/kg) did not affect the promnesic effects induced by the D4 agonist, which nevertheless abolished the U99194A-induced promnesic effects. Additionally, the amnesic effects produced by the D3 agonist 7-OH-DPAT (0.01-1 microg/kg) was attenuated by PD168,077. These results suggest a potential role of dopamine D4 receptors in memory consolidation, which would be similar to that of the D1 and D2 receptors and probably opposite to that of the D3 receptors. [less ▲]

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See detailExfoliated polylactide/clay nanocomposites by in-situ coordination-insertion polymerization
Paul, Marie-Amélie; Alexandre, Michaël ULg; Degée, Philippe et al

in Macromolecular Rapid Communications (2003), 24(9), 561-566

Poly(L-lactide)/layered aluminosilicate nanocomposites were synthesized in bulk by ring-opening polymerization in the presence of two organo-modified montmorillonites. When the organo-modifier consisted ... [more ▼]

Poly(L-lactide)/layered aluminosilicate nanocomposites were synthesized in bulk by ring-opening polymerization in the presence of two organo-modified montmorillonites. When the organo-modifier consisted of an ammonium cation bearing primary hydroxyl groups, polymerization was initiated by the alcohol functions after adequate activation. The growing polymer chains were directly "grafted" onto the clay surface through the hydroxyl-functionalized ammonium cations yielding exfoliated nano-composites with enhanced thermal stability. [less ▲]

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See detailHydrolytic and thermal degradation of random copolyesters of epsilon-caprolactone and 2-oxepane-1,5-dione
Dwan'Isa Latere, Jean-Pierre; Lecomte, Philippe ULg; Dubois, Philippe ULg et al

in Macromolecular Chemistry and Physics (2003), 204(9), 1191-1201

The hydrolytic and thermal stability of random copolyesters of epsilon-caprolactone (epsilon-CL) and ca. 30 mol-% 2-oxepane-1,5-dione (OPD) have been investigated. Compared with poly(epsilon-caprolactone ... [more ▼]

The hydrolytic and thermal stability of random copolyesters of epsilon-caprolactone (epsilon-CL) and ca. 30 mol-% 2-oxepane-1,5-dione (OPD) have been investigated. Compared with poly(epsilon-caprolactone) (PCL) of a comparable molecular weight, the hydrolytic degradation of the copolyester is faster in a phosphate buffer (pH = 7.4) at 37°C as confirmed by the time dependence of water absorption, weight loss, melting temperature, and molecular weight. This difference is a result of the higher hydrophilicity imparted to the copolyester by the ketone of the OPD units. The thermal degradation has been studied by thermogravimetric analysis (TGA), (HNMR)-H-1 spectroscopy, and size exclusion chromatography (SEC). The activation energy of the thermal degradation under nitrogen has been found to be lower for the copolyesters than for PCL, which indicates that the OPD co-units have a deleterious effect on the thermal stability of PCL. The thermal degradation primarily occurs by pyrolysis of the ester functions. [less ▲]

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See detailDiuretica en arteriële hypertensie
Krzesinski, Jean-Marie ULg

in Medi-Sfeer (2003), 23

De diuretica blijven één van de nuttigste therapeutische klassen bij de behandeling van arteriële hypertensie. Momenteel worden ze aanbevolen in een lage dosis. Met deze doses behouden diuretica hun ... [more ▼]

De diuretica blijven één van de nuttigste therapeutische klassen bij de behandeling van arteriële hypertensie. Momenteel worden ze aanbevolen in een lage dosis. Met deze doses behouden diuretica hun effect op de arteriële hypertensie, terwijl ze goed verdragen worden. Ze vormen de referentiebehandeling in cardiovasculaire preventiestudies. Omwille van hun lage kostprijs bieden ze ook een onmiskenbaar economisch voordeel. In de laatste aanbevelingen van de Wereldgezondeheidsorganisatie (WHO) en de International Society of Hypertension (ISH) vormen diuretica nog één van de meest valabele therapeutische klassen, vooral bij oudere patiënten en/of patiënten met systolische hypertensie en patiënten van het zwarte ras. Ze zijn vaak onmisbaar in antihypertensieve combinaties. [less ▲]

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See detailAtmospheric CO2 flux from mangrove surrounding waters
Borges, Alberto ULg; Djenidi, Salim ULg; Lacroix, Geneviève et al

in Geophysical Research Letters (2003), 30(11),

[1] The partial pressure of CO2 (pCO(2)) was measured at daily and weekly time scales in the waters surrounding mangrove forests in Papua New Guinea, the Bahamas and India. The pCO(2) values range from ... [more ▼]

[1] The partial pressure of CO2 (pCO(2)) was measured at daily and weekly time scales in the waters surrounding mangrove forests in Papua New Guinea, the Bahamas and India. The pCO(2) values range from 380 to 4800 muatm. These data, together with previously published data, suggest that overall oversaturation of CO2 with respect to atmospheric equilibrium in surface waters is a general feature of mangrove forests, though the entire ecosystems (sediment, water and vegetation) are probably sinks for atmospheric CO2. The computed CO2 fluxes converge to about +50 mmolC m(-2) day(-1). If this conservative value is extrapolated for worldwide mangrove ecosystems, the global emission of CO2 to the atmosphere is about 50 10(6) tC year(-1). Based on this tentative estimate, mangrove waters appear to be regionally a significant source of CO2 to the atmosphere and should be more thoroughly investigated, especially at seasonal time scale. [less ▲]

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See detailBulletin météorologique - Mai 2003
Tychon, Bernard ULg; Ozer, Pierre ULg; Eerens, M. et al

in Bulletin Agrométéorologique (2003)

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See detailTridimensional Dissipative Semi-Numerical Model
Jancart, Sylvie ULg; Lemaitre, Anne

in Earth, Moon, and Planets (2003), 92

Our research combines mean motion resonances and dissipative forces in the averaged elliptic spatial restricted three-body problem. The models presented can be applied in many contexts mixing resonances ... [more ▼]

Our research combines mean motion resonances and dissipative forces in the averaged elliptic spatial restricted three-body problem. The models presented can be applied in many contexts mixing resonances and dissipations, e.g., asteroid belt, transneptunian region, exoplanets, systems of planetary rings, etc. We propose a semi-numerical model that simulates the behaviour of test particles under the effect of generic forces, functions of powers of the position and/or of the velocity. This model is valid for any orbital eccentricities or inclinations, even at high values. Captures around symmetric and asymmetric equilibria are reproduced and the apparitions of a plateau of inclination for long periods of time are dectected. [less ▲]

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See detailPreparation of low-density xerogels from mixtures of TEOS with substituted alkoxysilanes. I. O-17 NMR study of the hydrolysis-condensation process
Alié, Christelle ULg; Pirard, Jean-Paul ULg

in Journal of Non-Crystalline Solids (2003), 320(1-3), 21-30

Low-density xerogels were synthesised by incorporation of an additive to base catalysed tetraethylorthosilicate (TEOS) alcogels directly during the preparation of the sol. The nucleation mechanism by the ... [more ▼]

Low-density xerogels were synthesised by incorporation of an additive to base catalysed tetraethylorthosilicate (TEOS) alcogels directly during the preparation of the sol. The nucleation mechanism by the additive was established by experiments during sol-gel transition. O-17 NMR spectroscopy on TEOS-ethanol-water, 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS)-ethanol-water and EDAS-TEOS-ethanol-water solutions shows that the hydrolysis-condensation of EDAS is much faster than that of TEOS. Consequently it can be assumed that EDAS forms nuclei, onto which TEOS condenses later to form the silica particles. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailAsteroseismology of HD 129929: Core Overshooting and Nonrigid Rotation
Aerts, C.; Thoul, Anne ULg; Daszynska, J. et al

in Science (2003), 300

We have gathered and analyzed 1493 high-quality multicolor Geneva photometric data taken over 21 years of the B3V star HD 129929. We detect six frequencies, among which appear the effects of rotational ... [more ▼]

We have gathered and analyzed 1493 high-quality multicolor Geneva photometric data taken over 21 years of the B3V star HD 129929. We detect six frequencies, among which appear the effects of rotational splitting with a spacing of ~0.0121 cycles per day, which implies that the star rotates very slowly. A nonadiabatic analysis of the oscillations allows us to constrain the metallicity of the star to Z â [0.017,0.022], which agrees with a similar range derived from spectroscopic data. We provide evidence for the occurrence of core convective overshooting in the star, with alpha[SUB]ov[/SUB] = 0.10 +/- 0.05, and we rule out rigid rotation. [less ▲]

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See detailPreparation of low-density xerogels from mixtures of TEOS with substituted alkoxysilanes. II. Viscosity study of the sol-gel transition
Alié, Christelle ULg; Pirard, René ULg; Pirard, Jean-Paul ULg

in Journal of Non-Crystalline Solids (2003), 320(1-3), 31-39

Mixtures of TEOS with substituted methoxysilanes generate low-density xerogels due to a nucleation mechanism involving the substituted alkoxysilane. The sol-gel transition of these mixtures was followed ... [more ▼]

Mixtures of TEOS with substituted methoxysilanes generate low-density xerogels due to a nucleation mechanism involving the substituted alkoxysilane. The sol-gel transition of these mixtures was followed by theological characterisation. The transition from sol to gel takes place in a few minutes at ambient temperature. For the series exhibiting nucleation by the additive. the gel time goes through a slight minimum when the ratio of additive/main reagent increases. The elastic modulus increases with increasing ratio of additive/main reagent as the particle size decreases because of the nucleation mechanism by the additive. Samples with smaller particles exhibit the highest modulus for equal silica concentrations. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailStudy of the morphology of copper hydroxynitrate nanoplatelets obtained by controlled double jet precipitation and urea hydrolysis
Henrist, Catherine ULg; Traina, Karl ULg; Hubert, Cédric ULg et al

in Journal of Crystal Growth (2003), 254(1-2), 176-187

A copper hydroxynitrate of stoichiometry Cu-2(OH)(3)NO3, analogous to the layered double hydroxide family, was synthesized by the so-called controlled double jet precipitation technique, and by hydrolysis ... [more ▼]

A copper hydroxynitrate of stoichiometry Cu-2(OH)(3)NO3, analogous to the layered double hydroxide family, was synthesized by the so-called controlled double jet precipitation technique, and by hydrolysis of urea in the presence of copper nitrate. Special attention has been focused on the size, morphology and agglomeration tendency of the particles. The aim of this work is to define the optimum precipitation conditions in terms of quality and dispersability of the recovered product. Such platelet-like particles Can be used as anisotropic fillers in nanocomposite materials. Several reaction parameters such as flow and concentration of the reactant solutions, design of the reactor and addition of a growth modifier were studied. (C) 2003 Elsevier -Science B.V. All rights reserved. [less ▲]

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See detailDesorption behaviour of regular adsorbed polyampholytic layers
Mahltig, Boris; Gohy, Jean-François; Jérôme, Robert ULg et al

in Journal of Polymer Research (2003), 10(2), 69-77

The desorption behaviour of the diblock polyampholyte PMAA-b-PDMAEMA, poly(methacrylic acid)-block-poly ((dimethylamino)ethyl methacrylate), preadsorbed on silicon substrates was investigated under the ... [more ▼]

The desorption behaviour of the diblock polyampholyte PMAA-b-PDMAEMA, poly(methacrylic acid)-block-poly ((dimethylamino)ethyl methacrylate), preadsorbed on silicon substrates was investigated under the influence of several desorption agents. The investigated polyampholyte is known to adsorb in regular structures directly from aqueous solutions onto silicon substrates. While the adsorption process is mainly determined by electrostatic interactions, two kinds of desorption mechanism should be assumed. The first mechanism is based on changed electrostatic conditions caused for instance by a strong change in pH of the aqueous solution. The other mechanism is observed after treatment with hydrophobic organic solvent, which leads to the desorption of hydrophobic adsorbed polyampholyte chains, while the electrostatically attached ones will not be influenced. To complete the desorption experiments with organic solvents also adsorption experiments from analogous polyampholytic solutions in the same organic solvents were performed. The amount of polymer at the substrate surface after adsorption or desorption experiments was determined using ellipsometry. Atomic force microscopy (AFM) was used to investigate the surface topography of dried samples after the desorption process. [less ▲]

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See detailPreparation of BaZrO3 powders by a spray-drying process
Robertz, B.; Boschini, Frédéric ULg; Rulmont, André ULg et al

in Journal of Materials Research (2003), 18(6), 1325-1332

The potential use of barium zirconate for the manufacture of corrosion-resistant substrates emphasizes the need for a simple, inexpensive, and easily scalable process to produce high-quality powders with ... [more ▼]

The potential use of barium zirconate for the manufacture of corrosion-resistant substrates emphasizes the need for a simple, inexpensive, and easily scalable process to produce high-quality powders with well-controlled composition and properties. However, the classical solid-state preparation of barium zirconate leads to an inhomogeneous powder unsuitable for applications in highly corrosive environment. For this paper, the possibility to use the spray-drying technique for the preparation of BaZrO3 powders with a controlled size distribution and morphology was investigated. The influence of the nature and concentration of the precursor solution and the influence of the spray-drying step are discussed on the basis of x-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and dilatometric measurements. [less ▲]

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See detailLa tachycardie ventriculaire catecholergique du jeune enfant: un diagnostic souvent meconnu
Massin, M.; Leroy, P.; Misson, Jean-Paul ULg et al

in Archives de Pédiatrie (2003), 10(6), 524-526

Catecholaminergic polymorphic ventricular tachycardia is important to be diagnosed as an underlying disease in children with syncope and normal heart, because of its poor prognosis. CASE REPORT: A 3-year ... [more ▼]

Catecholaminergic polymorphic ventricular tachycardia is important to be diagnosed as an underlying disease in children with syncope and normal heart, because of its poor prognosis. CASE REPORT: A 3-year-old boy was referred for stress and emotion induced syncope. Primary ventricular arrhythmia, consisting of salvos of bidirectional ventricular tachycardia, was reproducibly induced by physical exertion. The syncopal events and severe arrhythmia disappeared with beta-blocking therapy. CONCLUSION: Despite its rare occurrence, catecholaminergic polymorphic ventricular tachycardia is an important cause of stress and emotion induced syncope and sudden death in children. [less ▲]

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See detailLa prise en charge cardiaque preoperatoire du patient vasculaire
Van Damme, Hendrik ULg; Larbuisson, Robert ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2003), 58(6), 409-14

Peripheral vascular surgery (carotid, infrainguinal or aortoiliacal) is characterised by an increased cardiac risk with an infarction rate of 1 to 4%. Sixty percent of the vascular patients present a ... [more ▼]

Peripheral vascular surgery (carotid, infrainguinal or aortoiliacal) is characterised by an increased cardiac risk with an infarction rate of 1 to 4%. Sixty percent of the vascular patients present a concomitant coronary artery disease, often infraclinically. Preoperative cardiac risk stratification aims at reducing cardiac related morbidity and mortality. A clinical risk profile (patient's past history) and non-invasive cardiac tests allow subdividing the vascular patients into three categories: high risk, intermediate risk, and low risk. High-risk patients (unstable angina, recent infarction, overt congestive heart failure and critical aortic valve stenosis) require immediate intensive management of their underlying cardiac disease. This means delay or annulation of the planned vascular operation. For intermediate risk patients, a clinical cardiac risk index based on patient's past history (stable angina, previous infarction or episode of congestive heart failure, age of 70 years or more and diabetes) offers a rough orientation. These clinical markers lack specificity, since they are found in almost all vascular patients. The adjunction of a non-invasive cardiac testing allows to optimise the cardiac risk evaluation. Stress echocardiography with dobutamine has become a very popular test, with a negative predicting value exceeding 90%, but with a lack of specificity (many vascular patients have an uneventful postoperative outcome, despite a positive dobutamine test). These inconsistent results of cardiac risk evaluation render their routine use questionable. Nowadays, the management of patients requiring vascular surgery is based on the concept that every vascular patient should be considered as suffering from coronary artery disease. A certain degree of myocardial protection should be offered to every vascular surgery candidate. A preoperative treatment with betablockers provides myocardial protection against the operative stress and lowers myocardial oxygen requirement. There are arguments to continue or start aspirin treatment in the preoperative period, in order to lower the risk of sudden coronary thrombosis. [less ▲]

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See detailLa vaccination a base de mycobacteries: vaincra-t-elle les allergies?
Louis, Renaud ULg

in Revue Médicale de Liège (2003), 58(6), 392-5

In developed countries, the prevalence of tuberculosis has evolved in an opposite direction as to the one of allergy over the last century. The immunological response is mainly Th1 in tuberculosis while ... [more ▼]

In developed countries, the prevalence of tuberculosis has evolved in an opposite direction as to the one of allergy over the last century. The immunological response is mainly Th1 in tuberculosis while it features a Th2 pattern in allergy. Vaccination with BCG in early life is associated with a reduction in the prevalence of allergy later in childhood. In an experimental mouse model of asthma, administration of BCG or killed Mycobacterium vaccae inhibits the sensitisation process as well as the bronchial inflammation and hyperresponsiveness that follows allergen exposure. In children and adolescents suffering from atopic dermatitis, subcutaneous injection of killed Mycobacterium vaccae attenuates the severity of skin lesions. [less ▲]

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See detailPrevention de la necrose des membres inferieurs et de l'amputation par pontages femoro-tibiaux: indications, technique et resultats
Van Damme, Hendrik ULg; Baguet, E.; Zhang, Lihong ULg et al

in Revue Médicale de Liège (2003), 58(6), 415-28

Limb threatening ischemia is a challenge for the vascular surgeon. Recent progress in revascularization procedures allow to minimize the primary amputation rate in the management of chronic critical limb ... [more ▼]

Limb threatening ischemia is a challenge for the vascular surgeon. Recent progress in revascularization procedures allow to minimize the primary amputation rate in the management of chronic critical limb ischemia. The authors discuss the prevalence and causes of chronic critical limb ischemia, with a special interest for diabetic arteriopathy. The technique of crural and pedal vessel revascularization is described, as well as the innovative tourniquet technique for distal bypass surgery. A review of published series of infrapopliteal bypass surgery is made. The experience of the authors during last decade with crural and pedal bypass surgery is analyzed. [less ▲]

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See detailIn die Pfanne zu hauen Annika Reichs "Teflon" reflektiert die Welt im Spiegelei
Pontzen, Alexandra ULg

in Literaturkritik.de (2003)

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See detailLa connotation chez Hjelmslev
Badir, Sémir ULg

in Bulletin de l'Association française de sémiotique (2003), 3

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See detailOccurrence of MRSA endocarditis during linezolid treatment
Ben Mansour, El Hassan; Jacob, Eric; Monchi, Mehran et al

in European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology (2003), 22(6), 372-373

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See detailTechnology Development for In-Flight Oxygen Collection TSTO's
Hendrick, Patrick; Verstraete, D.; Bizzarri, Didier et al

in European Journal of Mechanical and Environmental Engineering (2003), 48 n°2

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See detailLong-term memory effects on verbal short-term memory : a replication study
Majerus, Steve ULg; Van der Linden, Martial ULg

in British Journal of Developmental Psychology (2003), 21(Part 2), 303-310

The influence of lexico-semantic language representations stored in long-term memory (LTM) on short-term memory (STM) performance has been studied extensively in adults. However, there are relatively few ... [more ▼]

The influence of lexico-semantic language representations stored in long-term memory (LTM) on short-term memory (STM) performance has been studied extensively in adults. However, there are relatively few data on lexico-semantic LTM effects on STM in children. On the other hand, the influence of phonological LTM effects on STM has been studied more extensively in children than in adults. In this study, we explored whether these different LTM effects on verbal STM could be replicated in both adults and children by administering immediate serial recall tasks (ISR) for high- and low-frequency words, for high- and low-imageability words, for words and non-words, and for high and low phonotactic frequency non-words to 6-, 8-, and 10-year-old children, to adolescents and to adults. Significant word frequency, lexicality and phonotactic frequency effects were observed in all age groups, as well as a word imageability effect which was, however, weaker than the other three effects. Our data suggest that LTM effects on STM are equivalent in both children and adults. [less ▲]

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See detailDeterminants of left ventricular preload-adjusted maximal power
Segers, Patrick; Tchano-Sato, Vincent; Leather, H. Alex et al

in American Journal of Physiology - Heart and Circulatory Physiology (2003), 284(6), 2295-2301

Maximal left ventricular (LV) hydraulic power output (PWRmax), corrected for preload as PWRmax/(V-ed)(beta) (where V-ed is the end-diastolic volume and beta is a constant coefficient), is an index of LV ... [more ▼]

Maximal left ventricular (LV) hydraulic power output (PWRmax), corrected for preload as PWRmax/(V-ed)(beta) (where V-ed is the end-diastolic volume and beta is a constant coefficient), is an index of LV contractility. Whereas preload-adjusted maximal power (PAMP) is usually calculated with beta = 2, there is uncertainty about the optimal value of beta (beta = 1 for the normal LV and 2 for the dilated LV). The aim of this work is to study the determining factors of beta. The data set consisted of 245 recordings (steady state and vena cava occlusion) in 10 animals in an ischemic heart pig model. The occlusion data yielded the slope (E-es; 2.01 +/- 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V-0; -11.9 +/- 22.6 ml; range -76 to 39 ml) of the end-systolic pressure-volume relation, and the optimal beta-factor (assessed by fitting an exponential curve through the V-ed-PWRmax relation) was 1.94 +/- 0.88 (range 0.29-4.73). The relation of beta with V-ed was weak [beta = 0.60 + 0.02(V-ed); r(2) = 0.20]. In contrast, we found an excellent exponential relation between V-0 and beta [beta = 2.16e(0.0189(V0)), r(2) = 0.70]. PAMP, calculated from the steady-state data, was 0.64 +/- 0.40 mW/ml(2) (range 0.14-2.83 mW/ml(2)) with a poor correlation with E-es (r = 0.30, P < 0.001). An alternative formulation of PAMP as PWRmax/(V-ed - V-0)(2), incorporating V-0, yielded 0.47 +/- 0.26 mW/ml(2) (range 0.09-1.42 mW/ml(2)) and was highly correlated with E-es (r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV power requires incorporation of V-0 and thus of data measured under altered loading conditions. [less ▲]

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See detailEffects of repetitive transcranial magnetic stimulation on visual evoked potentials: new insights in healthy subjects
Fumal, Arnaud ULg; Bohotin, V.; Vandenheede, Michel et al

in Experimental Brain Research (2003), 150(3), 332-340

In a previous comparative study with migraineurs, we found in 24 normal subjects that the amplitude of the pattern-reversal visual evoked potential (PR-VEP) in the first block of 100 responses and its ... [more ▼]

In a previous comparative study with migraineurs, we found in 24 normal subjects that the amplitude of the pattern-reversal visual evoked potential (PR-VEP) in the first block of 100 responses and its habituation over 6 sequential blocks were significantly decreased after 1 Hz repetitive transcranial magnetic stimulation (rTMS), while 10 Hz rTMS had no significant effect. We report here our results on the reproducibility of the rTMS effect studied in ten of these subjects by repeating the recordings for each frequency three times on different days. We have also reanalysed the data obtained in 24 normal subjects, looking separately at the results in those stimulated at an intensity equal to phosphene threshold (group 1; n=14) and those stimulated at 110% of motor threshold because of unelicitable phosphenes (group 2; n=10). We finally determined the precise duration of the rTMS effect. Despite some interindividual variability, the effects of both rTMS frequencies on first block amplitude, habituation between first and sixth block and habituation slope over the six blocks were highly reproducible. The only difference between the two groups of subjects was the effect of 1 Hz rTMS on the second measured PR-VEP component. Whereas first block amplitude of the first P1-N1 component and habituation were decreased in both groups, such a decrease was found for the second P1-N2 component only in group 1 stimulated at phosphene threshold. The dishabituation of the N1-P1 component after 1 Hz rTMS was maximal at 15 min, but lasted up to 33 min, while that of P1-N2 disappeared after 3 min. There was a non-significant trend ( p=0.06) for a reduction of first block amplitude after 10 Hz rTMS in the total group of subjects, but no effect on habituation. The inhibitory effect of 1 Hz rTMS, which reduces in healthy controls both first block PR-VEP amplitude and habituation, probably by decreasing the preactivation excitability level of the underlying visual cortex, is thus reproducible and long lasting. Long trains of 10 Hz rTMS tend to attenuate reproducibly the cortical preactivation level in normal subjects, but they do not affect habituation at all, which contrasts with their effect in migraineurs, in whom, as previously reported, they significantly correct the habituation deficit. The absence of an effect of 1 Hz rTMS on PR-VEP P1-N2 in subjects stimulated at 110% of motor threshold may be explained by the deeper anatomical location of the cortical generators of this component and the lower stimulation intensity used. Taken together our results confirm that the effect of rTMS on the underlying cortex depends on several variables such as frequency, intensity and level of cortical preactivation. [less ▲]

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See detailPrévention de l'insuffisance rénale chronique chez l'adulte
Krzesinski, Jean-Marie ULg; Dubois, Bernard ULg; Rorive, Georges ULg

in Revue Médicale de Liège (2003), 58(6), 369-377

Chronic renal failure is an unrecognised disease, with an insidious and rather silent development, for which the general practitioners are too often passive. This review would like to insist on the ... [more ▼]

Chronic renal failure is an unrecognised disease, with an insidious and rather silent development, for which the general practitioners are too often passive. This review would like to insist on the detection of people at risk or with early abnormalities, on the optimal guidelines to slowdown the evolution to more severe and irreversible stages, on the prevention of uremic and cardiovascular complications and on the preparation to end stage renal treatments. [less ▲]

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See detailRecherche sur les embryons: la fortune sourira-t-elle aux audacieux?
Leleu, Yves-Henri ULg

in 15e Jour du Mois (Le) (2003)

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See detailPrevention du paludisme chez l'adulte
Leonard, Philippe ULg; Moutschen, Michel ULg; Demonty, Jean ULg

in Revue Médicale de Liège (2003), 58(6), 382-7

Great scourge of poor countries, malaria is the most important tropical parasitic disease. It is responsible for a large number of deaths in concerned countries and represents a real danger for travellers ... [more ▼]

Great scourge of poor countries, malaria is the most important tropical parasitic disease. It is responsible for a large number of deaths in concerned countries and represents a real danger for travellers going to endemic regions. So, prophylactic measures are essential. On the one hand protective measures against mosquito bites, by wearing covering clothes, by using repellents and bed net (eventually impregnated with insecticide) will be useful. On the other hand, chemoprophylaxis is most often necessary, adapted to the possibility of chloroquine resistant P. falciparum, to the length or conditions of travel, and to the traveller's antecedents and age. Special concern about pregnant woman is necessary, due to potential severity of malaria. Chemoprophylaxis needs to be continued after coming back, for a duration depending on the drug used. Unfortunately, no prophylaxis is 100% effective, and the appearance of fever during the travel or two to three months after return requires medical advice. In some circumstances, it is necessary to prescribe a stand-by emergency treatment, if no quick medical advice is possible. [less ▲]

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See detailBehavior of bulk melt-textured YBCO single domains subjected to crossed magnetic fields
Vanderbemden, Philippe ULg; Dorbolo, Stéphane ULg; Hari-Babu, N. et al

in IEEE Transactions on Applied Superconductivity (2003), 13(2, Part 3), 3746-3749

We have experimentally investigated the crossed magnetic field effects on bulk melt-processed YBCO single domains. The samples were first permanently magnetized along their c-axis and then subjected to ... [more ▼]

We have experimentally investigated the crossed magnetic field effects on bulk melt-processed YBCO single domains. The samples were first permanently magnetized along their c-axis and then subjected to several cycles of a transverse magnetic field parallel to the ab planes. The magnetic properties along the c and ab directions were simultaneously measured using a couple of orthogonal pick-up coils as well as a Hall probe placed against the sample surface. The effects of both sweep amplitude and polarity were investigated. Field sweeps of alternate polarities are shown to affect the decay of the c-axis magnetization much more strongly than field sweeps of unique polarity do. However, the c-axis magnetization does not show any saturation even after a large number of field sweeps. Next, a micro-Hall probe scanning system was used to measure the distribution of magnetic induction over the top surface of the single domain subjected to the same combination of magnetic fields. The results are shown to be consistent with those determined with the sensing coils and bring out the role played by geometric effects. (C) 2003 IEEE. [less ▲]

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See detailAlteration of left ventriculo-arterial coupling and mechanical efficiency during acute myocardial ischemia
Kolh, Philippe ULg; Lambermont, Bernard ULg; Ghuysen, Alexandre ULg et al

in International Angiology (2003), 22(2), 148-158

AIM: Myocardial revascularisation being frequently performed during acute myocardial ischemia, in a hostile hemodynamic environment, we evaluated left ventriculo-arterial (VA) coupling, left ventricular ... [more ▼]

AIM: Myocardial revascularisation being frequently performed during acute myocardial ischemia, in a hostile hemodynamic environment, we evaluated left ventriculo-arterial (VA) coupling, left ventricular (LV) mechanical efficiency, and the mechanical properties of the systemic vasculature during acute myocardial ischemia. METHODS: In 6 pigs, vascular properties [characteristic impedance (R(1)), peripheral resistance (R(2)), compliance (C), inductance (L), arterial elastance (E(a))] were estimated with a windkessel model. LV function was assessed by the slope (E(es)) of end-systolic pressure-volume relationship (ESPVR), and stroke work (SW) - end-diastolic volume (EDV) relation. Pressure-volume area (PVA) was referred to as myocardial oxygen consumption. VA coupling was defined as E(es)/E(a), and mechanical efficiency as SW/PVA. After baseline recordings, the left anterior descending coronary artery was ligated and hemodynamic measures obtained every 30 minutes for 3 hours. Data are expressed as mean (SEM). RESULTS: Coronary occlusion induced an ESPVR rightward shift, and decreased E(es) from 3.67 (0.33) to 1.92 (0.20) mmHg/ml and the slope of the SW - EDV relationship from 72.3 (3.4) to 40.4 (4.5) mmHg (p<0.001), while E(a) increased from 3.33 (0.56) to 4.65 (0.29) mmHg/ml (p<0.005). This was responsible for a dramatic alteration of VA coupling from 1.22 (0.11) to 0.44 (0.07), (p<0.001). While R2 increased from 1.72 (0.30) to 2.38 (0.16) mmHg x s x ml(-1) (p<0.05) and C decreased from 0.78 (0.16) to 0.46 (0.08) ml/mmHg (p<0.05), R(1) and L were unchanged. Coronary occlusion decreased SW from 4056 (223) to 2580 (122) mmHg.ml (p<0.001), while PVA and SW/PVA decreased from 5575 (514) to 4813 (317) mmHg x ml (NS), and from 0.76 (0.04) to 0.57 (0.03) (p<0.001), respectively. CONCLUSION: Acute myocardial ischemia severely altered left ventriculo-arterial coupling and LV mechanical efficiency. Impaired left VA coupling was due to a combination of augmented arterial elastance, secondary to early vasoconstriction later associated with decreased arterial compliance, and decreased LV contractility. [less ▲]

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See detailCeramic Journal Bearing in Cryogenic Turbo-Pumps
Nelis, M.; Bozet, Jean-Luc ULg; BICKEL, M. et al

in European journal of mechanical and environmental engineering (2003), 48(no2), 73-80

The availability of components built in CMC technology forms in major areas a prerequisite for the realisation of future reusable launcher engines. Apart from the efforts to introduce CMC components in ... [more ▼]

The availability of components built in CMC technology forms in major areas a prerequisite for the realisation of future reusable launcher engines. Apart from the efforts to introduce CMC components in the hot areas of the engine like nozzles and thrust chambers there exists an important optimisation potential in the engines through the use of CMC components in (cryogenic) turbo-pumps. By replacement of the ball bearings in the pumps by journal bearings, a significantly higher lifetime can be obtained and the inherent limitation of the turning speed of the pumps can be widely extended. The CMC journal bearings of MAN have proven their quality and reliability in numerous applications in industrial pumps. Based on this experience a research program was initiated by DLR and funded by means of the BMBF and MAN to investigate the use of this bearing type under the conditions of a cryogenic turbo-pump. Major results are presented in this paper. [less ▲]

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See detailDose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type 1: Implications for clinical trials
Lambert, Vincent ULg; Munaut, Carine ULg; Carmeliet, Peter et al

in Investigative Ophthalmology & Visual Science (2003), 44(6), 2791-2797

PURPOSE. To explain the conflicting reports about the influence of plasminogen activator inhibitor type (PAI-1) on pathologic angiogenesis, such as occurs during the exudative form of age-related macular ... [more ▼]

PURPOSE. To explain the conflicting reports about the influence of plasminogen activator inhibitor type (PAI-1) on pathologic angiogenesis, such as occurs during the exudative form of age-related macular degeneration. METHODS. The expression of PAI-1 mRNA was analyzed in human and murine choroidal neovascularization (CNV) by RTPCR. The influences of increasing doses of recombinant PAI-1 were evaluated by daily intraperitoneal injections in PAI-1-1-and wild-type animals with a model of laser-induced CNV. The double mechanism of action of PAI-1 (proteolytic activity inhibition versus vitronectin binding) was explored by immunohistochemical localization of fibrinogen/fibrin and by injection of recombinant PAI-1 protein defective for vitronectin binding or with adenoviral vectors bearing a mutated binding-deficient PAI-1 gene. RESULTS. PAI-1 expression was present in human CNV and strongly induced in the course of experimental subretinal neovascularization. Daily injections of recombinant PAI-1 proteins in control and PAI-1(-/-) animals demonstrated that PAI-1 could exhibit both pro- and antiangiogenic effects, dependent on the dose. PAI-1 mutants defective for vitronectin binding were used to show that PAI-1 promotes choroidal pathologic angiogenesis merely through its antiproteolytic activity. CONCLUSIONS. These observations may help to reconcile reports with opposite results regarding the effects of PAI-1 on angiogenesis and certainly warn against uncontrolled use of PAL I modulating drugs in clinical trials. [less ▲]

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See detailDifferential gene expression in two potato lines differing in their resistance to Phytophthora infestans
Evers, Danièle; Ghislain, Marc; Hausman, Jean-François et al

in Journal of Plant Physiology (2003), 160(6), 709-712

Horizontal resistance to late blight in the potato is a primary objective of many breeding programs. Knowledge of the physiological and biochemical mechanisms underlying it, however, is scarce. The ... [more ▼]

Horizontal resistance to late blight in the potato is a primary objective of many breeding programs. Knowledge of the physiological and biochemical mechanisms underlying it, however, is scarce. The purpose of the present study was the identification of these physiological and biochemical factors in plant material obtained by crossing a late blight resistant Solanum phureja clone with a susceptible dihaploid of S. tuberosum subsp. tuberosum. The mRNA RT-PCR differential display method was used to compare the gene expression patterns of a resistant hybrid with that of a susceptible one. By sequence homology, we identified several genes with diverse functions, including genes known to be involved in resistance or stress responses and genes known to be involved in primary or secondary metabolism. [less ▲]

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See detailCommunication, positionnement et GPS
Debouche, Charles ULg

in Journal des Ingénieurs (Le) (2003), 87

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See detailHealth-related quality of life and cost of ambulatory care in osteoporosis: how may such outcome measures be valuable information to health decision makers and payers?
Ethgen, Olivier ULg; Tellier, V.; Sedrine, W. B. et al

in BONE (2003), 32(6), 718-724

The objective was to quantify the outcome of osteoporosis (OP) in terms of health-related quality of life (HR-QOL) and cost of ambulatory care and to look at the association between these two outcomes ... [more ▼]

The objective was to quantify the outcome of osteoporosis (OP) in terms of health-related quality of life (HR-QOL) and cost of ambulatory care and to look at the association between these two outcomes variables. A cross-sectional health survey of 4800 Belgian individuals over the age of 45 years was used. Individuals having reported OP were retrieved and for each of them, at least two matched individuals for age, sex, residency location, and health insurance status were identified. All individuals were assessed with the SF-36. The two major health insurance providers furnished cost value for ambulatory care. HR-QOL and cost data were compared between the OP group and control group. Beta-coefficients from linear regression were calculated to give information on the relative importance of the association between each SF-36 dimensions and cost of ambulatory care. Of 4796 individuals appropriately surveyed, 221 (4.8%) reported OP. The control group included 651 individuals. The OP group experienced impaired HR-QOL compared to their matched counterparts, all the difference in mean or median SF-36 scores being significant at the level of P < 0.001. Osteoporotic respondents averaged 816 in cost of ambulatory care whereas controls averaged 579 (P < 0.001). When looking at detailed comparisons between categories of cost, costs in the OP group far exceeded those in the control group, all the differences being significant at the level of P < 0.001 except for home health nurse (P = 0.012). In the OP group, vitality dimensions played the most important role in the determination of cost (beta = -0.28, P < 0.001), followed by physical functioning (beta = -0.26, P < 0.01), general health, and social functioning (beta = -0.23, P < 0.01). This study evidences the burden of OP in terms of HR-QOL and cost of ambulatory care. Exploring the association between HR-QOL and cost show that mental dimension such as vitality can play an important role in the determination of cost. Conclusively, they should not be neglected in future management of OP. [less ▲]

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See detailEvaluation, severity and prognostic significance of silent myocardial ischaemia in vascular patients
Sprynger, Muriel ULg

in Acta Chirurgica Belgica (2003), 103(3), 255-261

This paper intends to make an update of recent publications and guidelines for evaluation in coronary symptom-free patients undergoing vascular surgery. It emphasizes the role of preoperative clinical ... [more ▼]

This paper intends to make an update of recent publications and guidelines for evaluation in coronary symptom-free patients undergoing vascular surgery. It emphasizes the role of preoperative clinical evaluation that should identify the most appropriate testing, and treatment strategies to optimize care of the patient and avoid unnecessary testing in this era of cost containment. Selective preoperative coronary artery disease screening and revascularization achieve excellent perioperative and late results after high-risk vascular surgery. Supplemental preoperative evaluation is discussed (exercise ECG, stress echocardiography and stress tomoscintigraphy). Asymptomatic patients with good functional capacity can undergo intermediate-risk surgery without further non-invasive testing. Conversely, further noninvasive testing is often considered for patients with poor functional capacity or moderate functional capacity but higher-risk surgery especially for patients with 2 or more intermediate risk predictors. Additional testing may be considered on an individual basis for patients without clinical markers but with poor functional capacity prior to vascular surgery, particularly those with several minor clinical risk predictors. Because of a higher prevalence of silent myocardial ischaemia in diabetes mellitus, these patients require specific care. Until further data are available, indications for myocardial revascularization in the perioperative setting are similar to those in the ACC/AHA guidelines for use of myocardial revascularization in general. General practioners, cardiologists, angiologists, vascular surgeons and anaesthesiologists should collaborate and aim to slow down the progression of atherosclerosis by giving their patients an optimum secondary cardiovascular prevention. [less ▲]

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See detailAnisotropic AC behavior of multifilamentary Bi-2223/Ag tapes
Fagnard, Jean-François ULg; Vanderbemden, Philippe ULg; Cloots, Rudi ULg et al

in IEEE Transactions on Applied Superconductivity (2003), 13(2, Part 3), 2976-2979

In this communication, we report on the anisotropy of the superconducting properties of multifilamentary Bi-based tapes experimentally investigated by AC magnetic susceptibility measurements. The ... [more ▼]

In this communication, we report on the anisotropy of the superconducting properties of multifilamentary Bi-based tapes experimentally investigated by AC magnetic susceptibility measurements. The susceptibility X = X' - jX" was measured using a commercial system and a couple of orthogonal pick-up coils. The X'' vs. temperature curves were shown to exhibit two peaks. The smaller of the peaks, occurring near T = 72 K, was only visible for particular field directions and within a given frequency window. Such results point out the role played by the phase difference between the applied magnetic field and the internal magnetic field seen by the filaments. (C) 2003 IEEE. [less ▲]

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See detailFaire face à une suspicion de parvovirose canine
Thiry, Etienne ULg

in Point Vétérinaire (2003), 34(236, Suppl. S), 39633

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See detailStructural evolution of lamellar surfactant-silica hybrids upon calcination
Henrist, Catherine ULg; Cano, I. G.; Rodriguez, M. A. et al

in Composites Science and Technology (2003), 63(8), 1127-1131

A lamellar mesostructured silica was subjected to a progressive heat treatment in order to study its structural evolution and the characteristics of the resulting calcined powder. By combining ... [more ▼]

A lamellar mesostructured silica was subjected to a progressive heat treatment in order to study its structural evolution and the characteristics of the resulting calcined powder. By combining informations from several physical methods, i.e. TG-DTA, XRD, TEM and nitrogen adsorption, it has been possible to evidence the formation of very small particles of silica at a temperature around 450 degreesC, exhibiting a very high value of aspect ratio, consequently to the template loss by combustion. By increasing the temperature above 530 degreesC, the dehydroxylation promotes a decrease in the surface area, followed by the sintering process at higher temperature, which nearly annihilate the surface area of the particles. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPeripheral vascular surgery: Update on the perioperative non-surgical management for high cardiac risk patients
Stammet, P.; Senard, Marc ULg; Roediger, Laurence ULg et al

in Acta Chirurgica Belgica (2003), 103(3), 248-254

This review of the recent literature regarding perioperative management in peripheral vascular surgery emphasizes some of the important features for the 2003 state-of-the-art on non surgical perioperative ... [more ▼]

This review of the recent literature regarding perioperative management in peripheral vascular surgery emphasizes some of the important features for the 2003 state-of-the-art on non surgical perioperative care for these high cardiac risk patients. The most adapted preoperative cardiac evaluation for each patient is guided by its individual risk factors and clinical history. Perioperative medication should nowadays consist of pre- and postoperative beta-blockers and acetyl salicylic acid, both reducing cardiac morbidity and mortality. Neuraxial locoregional anaesthesia techniques are reasonable alternatives to general anaesthesia because of their potential advantages, by reducing postoperative inflammatory response and reducing procoagulating activity, and increasing peripheral vascular graft patency, but the individual benefit/risk balance has always to be evaluated for patients submitted to aggressive antithrombotic therapy. During the postoperative course, early detection and treatment of postoperative myocardial ischemia or infarction by ST wave changes and/or cardiac enzyme control has to be considered. [less ▲]

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See detailHyperfine structure for neutral manganese lines of astrophysical interest
Lefèbvre, P.-H.; Garnir, Henri-Pierre ULg; Biémont, Emile ULg

in Astronomy and Astrophysics (2003), 404(3), 1153-1158

The hyperfine structure of 40 levels of neutral manganese has been studied by means of Fourier transform emission spectroscopy. The light source was a home-made 99.5% pure manganese hollow-cathode lamp ... [more ▼]

The hyperfine structure of 40 levels of neutral manganese has been studied by means of Fourier transform emission spectroscopy. The light source was a home-made 99.5% pure manganese hollow-cathode lamp. From the analysis of the line profiles observed in the visible and infrared regions, we have been able to deduce new magnetic dipole constants for 18 levels and to revise previous results for 22 additional levels. [less ▲]

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See detailEvoked potentials and transcranial magnetic stimulation in migraine: published data and viewpoint on their pathophysiologic significance.
Schoenen, Jean ULg; Ambrosini, Anna; Sandor, Peter S et al

in Clinical Neurophysiology (2003), 114(6), 955-72

Migraine is a disorder in which central nervous sytem dysfunction might play a pivotal role. Electroneurophysiology seems thus particularly suited to study its pathophysiology. We have extensively ... [more ▼]

Migraine is a disorder in which central nervous sytem dysfunction might play a pivotal role. Electroneurophysiology seems thus particularly suited to study its pathophysiology. We have extensively reviewed evoked potential and transcranial magnetic stimulation studies performed in migraineurs in order to identify their pathophysiologic significance. Publications available to us were completed by a Medline search. Retrieved and personal data were compared with respect to methodology and interpreted according to present knowledge on cortical information processing. Results are in part contradictory which appears to be method-, patient- and disease- related. Nonetheless, both evoked potential and transcranial magnetic stimulation studies demonstrate that the cerebral cortex, and possibly subcortical structures, are dysfunctioning interictally in both migraine with and without aura. These electrophysiologic abnormalities tend to normalise just before and during an attack and some of them seem to have a clear familial and predisposing character. Besides the studies of magnetophosphenes which have yielded contrasting results, chiefly because the method is not sufficiently reliable, most recent electrophysiologic investigations of cortical activities in migraine favour deficient habituation and decreased preactivation cortical excitability as the predominant interictal dysfunctions. We propose that the former is a consequence of the latter and that it could favour both interictal cognitive disturbances as well as a cerebral metabolic disequilibrium that may play a role in migraine pathogenesis. To summarize, electrophysiologic studies demonstrate in migraine between attacks a cortical, and possibly subcortical, dysfunction of which the hallmark is deficient habituation. [less ▲]

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See detailOwnership vs. Accountability, ou le contrôle des fonds de l’aide au développement
Paul, Elisabeth ULg

in Reflets et Perspectives de la Vie économique (2003), XLII(2), 29-43

The paper reviews the major changes observed in the mechanisms used to channel aid to developing countries. As the most recent PRGF approach places the emphasis on the need for a coherent framework (the ... [more ▼]

The paper reviews the major changes observed in the mechanisms used to channel aid to developing countries. As the most recent PRGF approach places the emphasis on the need for a coherent framework (the PRSP), a certain number of prerequisite on the management side of public expenditure need to be met. The paper reviews some of the most important aspects, in particular the need for better controls in the budgetary process. The paper uses a principal-agent approach to compare the impact of internal and external (audit) controls on the efficiency of service delivery and draws policy implications. [less ▲]

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See detailFurther exploration memory bias in compulsive washers
Ceschi, G.; Van der Linden, Martial ULg; Dunker, D. et al

in Behaviour Research and Therapy (2003), 41(6), 737-748

The aim of the present study was to replicate Radomsky and Rachman's findings on memory bias in obsessive-compulsive disorder (OCD), using the same procedure but an increased sample size, more specific ... [more ▼]

The aim of the present study was to replicate Radomsky and Rachman's findings on memory bias in obsessive-compulsive disorder (OCD), using the same procedure but an increased sample size, more specific control groups, and a full analysis of contamination attribution data. [less ▲]

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See detailSexual differentiation of the neuroendocrine mechanisms regulating mate recognition in mammals
Bakker, Julie ULg

in Journal of Neuroendocrinology (2003), 15(6), 615-621

When in breeding condition, male and female mammals seek out and mate with opposite-sex conspecifics. The neural mechanisms controlling mate recognition and heterosexual partner preference are sexually ... [more ▼]

When in breeding condition, male and female mammals seek out and mate with opposite-sex conspecifics. The neural mechanisms controlling mate recognition and heterosexual partner preference are sexually differentiated by the perinatal actions of sex steroid hormones. Many mammalian species use odours to identify potential mates. Thus, sex differences in partner preference may actually reflect sex differences in how male and female mammals perceive socially relevant odours. Two olfactory systems have evolved in vertebrates that differ considerably in their anatomy and function. It is generally believed that the main olfactory system is used to detect a wide variety of volatile odours derived from food prey among many sources, whereas the accessory olfactory system has evolved to detect and process primarily nonvolatile odours shown to influence reproductive behaviours and neuroendocrine functions. Some recent results obtained in oestradiol-deficient aromatase knockout (ArKO) mice that provide evidence for a developmental role of oestradiol in olfactory investigation of volatile body odours are discussed, suggesting that: (i) oestrogens contribute to the development of the main olfactory system and (ii) mate recognition is mediated by the main as opposed to the accessory olfactory system. Thus, sex differences in mate recognition and sexual partner preference may reflect sex differences in the perception of odours by the main olfactory system. [less ▲]

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See detailThe electrophysiology of migraine
Ambrosini, A.; Schoenen, Jean ULg

in Current Opinion in Neurology (2003), 16(3), 327-331

Purpose of review The pathophysiology of migraine is far from being understood. Electrophysiological methods are useful to investigate peripheral and central mechanisms underlying this disorder. The ... [more ▼]

Purpose of review The pathophysiology of migraine is far from being understood. Electrophysiological methods are useful to investigate peripheral and central mechanisms underlying this disorder. The purpose of this review is to highlight the results of electrophysiological studies published during the last year and to examine their added value to our previous knowledge. Recent findings Studies by visual and auditory evoked potentials and event-related responses suggested that lack of habituation is the principal interictal abnormality of sensory processing in migraineurs. Recently confirmed for somatosensory and laser-evoked cortical potentials and for brainstem responses, it is also responsible for the increased intensity dependence of auditory evoked potentials. This abnormality is possibly caused by a reduced cortical preactivation level due to hypofunctioning subcortico-cortical aminergic pathways. Although studies of cortical excitability by transcranial magnetic stimulation have yielded conflicting results, results obtained using habituation of pattern-reversal visual evoked potentials to explore cortical excitability changes induced by repetitive transcranial magnetic stimulation strongly favour the hypothesis that migraine is characterized by a decreased level of preactivation excitability. With regard to pain mechanisms in migraine, electrophysiological studies of trigeminal pathways using nociceptive blink and corneal reflexes have confirmed that sensitization of central trigeminal nociceptors occurs during the attack, and may even persist interictally. Summary Scientific publications over the last year confirmed that electrophysiological methods are particularly suited to unravelling some of the pathophysiological mechanisms of migraine. To improve their future contribution, they need to be better standardized and to be correlated with behavioural, metabolic and genetic studies. [less ▲]

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See detailStaging of primary cervical cancers: the role of nuclear medicine
Belhocine, Tarik; Kridelka, Frédéric ULg; Thille, Alain ULg et al

in Critical Reviews in Oncology/Hematology (2003), 46(3), 275-284

In nuclear medicine, [F-18]-fluorodeoxyglucose positron emission tomography ((18)FDG PET) and lymphatic mapping and sentinel lymphadenectomy (LM/SL) may significantly improve the staging of primary ... [more ▼]

In nuclear medicine, [F-18]-fluorodeoxyglucose positron emission tomography ((18)FDG PET) and lymphatic mapping and sentinel lymphadenectomy (LM/SL) may significantly improve the staging of primary cervical cancers. Indeed, the disease progresses in a 'level by level' fashion to regional nodes through the lymphatic channels, and also to extra-nodal sites via the hematogenous stream. Additionally, the sub-optimal efficacy of routine radiological protocols, while new combined therapies are proving to be more efficient, stresses the need for alternative staging procedures. Current data suggest that LM/SL accurately reflects the regional lymph node status in early stage cervical cancers, and thus could avoid unnecessary complete lymphadenectomies. Also, whole body (18)FDG PET may provide valuable insights on extra-pelvic and distant tumor spreading, with a significant impact on treatment choices. If these promising results are confirmed on large controlled trials, LM/SL and (18)FDG PET imaging could be incorporated in the routine staging work-up of primary cervical cancers. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailPrevention de la mortalite secondaire apres anevrysme dissequant de type B
Quaniers, Janine ULg; CREEMERS, Etienne ULg; Djekic, J. et al

in Revue Médicale de Liège (2003), 58(6), 400-3

Only few dissecting aneurysms type A survive without surgery. Opposingly, the dissecting aneurysms type B are successfully managed by the medical treatment "anti-impulsion". A personal series is reported ... [more ▼]

Only few dissecting aneurysms type A survive without surgery. Opposingly, the dissecting aneurysms type B are successfully managed by the medical treatment "anti-impulsion". A personal series is reported, that evidence important cardiovascular mortality in the follow-up in chronic dissecting aneurysms type B; one part of this late mortality is linked to rupture of the thoracic descending aorta. Thus, the prevention of this late mortality depends on a strict follow-up of the characters and dimensions of descending aortic thoracic aorta. [less ▲]

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See detailCardiologists and smoking
Kesteloot, H.; Pierard, Luc ULg

in Acta Cardiologica (2003), 58(3), 177-177

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See detailTransplantation cardiaque: prevention secondaire
Nellessen, Eric ULg; Lancellotti, Patrizio ULg; Demoulin, J. C. et al

in Revue Médicale de Liège (2003), 58(6), 429-34

Cardiac transplantation is the treatment of choice for refractory heart failure. An immunosuppressive therapy must be given in the perioperative course to avoid graft rejection. In this article, we review ... [more ▼]

Cardiac transplantation is the treatment of choice for refractory heart failure. An immunosuppressive therapy must be given in the perioperative course to avoid graft rejection. In this article, we review the main classes of immunosuppressive agents (calcineurin inhibitors, anti-metabolities, corticoids) and their side effects. The general preventive measures and the different kinds of rejection (hyperacute, acute vascular, acute cellular and chronical) are discussed. The current bacterial, protozoarian, mycotic and viral infections are described. We finish with the risk of cancer, mainly skin tumours and non-Hodgkinian lymphomas. [less ▲]

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See detailThe kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin-receptor shed a new light on the derepression of beta-lactamase synthesis
Duval, Valérie; Swinnen, Marc; Lepage, Sophie et al

in Molecular Microbiology (2003), 48(6), 1553-1564

To study the properties of the BlaR penicillin-receptor involved in the induction of the Bacillus licheniformis beta-lactamase, the water-soluble carboxy terminal domain of the protein (BlaR-CTD) was ... [more ▼]

To study the properties of the BlaR penicillin-receptor involved in the induction of the Bacillus licheniformis beta-lactamase, the water-soluble carboxy terminal domain of the protein (BlaR-CTD) was overproduced in the periplasm of Escherichia coli JM105 and purified to protein homogeneity. Its interactions with various beta-lactam antibiotics were studied. The second-order acylation rate constants k(2)/K' ranged from 0.0017 to more than 1 muM(-1) s(-1) and the deacylation rate constants were lower than 4x10(-5) s(-1) . These values imply a rapid to very rapid formation of a stable acylated adduct. BlaR-CTD is thus one of the most sensitive penicillin-binding proteins presently described. In the light of these results, the kinetics of beta-lactamase induction in Bacillus licheniformis were re-examined. When starting with a rather high cell density, a good beta-lactamase substrate such as benzylpenicillin is too sensitive to beta-lactamase-mediated hydrolysis to allow full induction. By contrast, a poor beta-lactamase substrate (7-aminocephalosporanic acid) can fully derepress beta-lactamase expression under conditions where interference of the antibiotic with cell growth is observed. These results suggest that acylation of the penicillin receptor is a necessary, but not sufficient, condition for full induction. [less ▲]

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See detailPre- and post-treatment with pirlindole and dehydropirlindole protects cultured brain cells against nitric oxide-induced death.
Boland, André ULg; Gérardy, Jean; Mossay, Danielle ULg et al

in European Journal of Pharmacology (2003), 466

We have previously shown that pirlindole and dehydropirlindole, two monoamine oxidase type-A inhibitors, protect cultured brain cells against iron-induced toxicity through a mechanism unrelated to ... [more ▼]

We have previously shown that pirlindole and dehydropirlindole, two monoamine oxidase type-A inhibitors, protect cultured brain cells against iron-induced toxicity through a mechanism unrelated to monoamine oxidase type-A inhibition. The current study was performed to test whether the protective effect of pirlindole and dehydropirlindole could be extended to a nitric oxide (NO)-induced insult. A comparison with other monoamine oxidase inhibitors (brofaromine, moclobemide and deprenyl) and with trolox was made. In a first series of experiments, rat hippocampal or cortical cultured cells were exposed to a drug for 3 h, then 5 muM sodium nitroprusside, a NO donor, was added and the incubation was continued for 16 h. Cell survival assessment showed that pirlindole, dehydropirlindole and trolox significantly protected cultures against NO-induced toxicity in a concentration-dependent manner with respective EC50's of 7, 3 and 17 muM. Similarly, pirlindole, dehydropirlindole or trolox, at a concentration of 50 muM, significantly decreased both intracellular peroxide production and lipoperoxidation. Other drugs were ineffective. In a post-hoc treatment protocol (3- or 6-h pre-incubation in the presence of sodium nitroprusside, then addition of one of the above mentioned compounds), only pirlindole and dehydropirlindole significantly improved cell survival in a concentration-dependent manner with respective EC50'S of 9 and 4 muM. The maximal protection in terms of cell survival was 90% and 78% after 3 and 6 h, respectively. They also reduced the production of both lipoperoxides and endoperoxides. Our results show that pirlindole and dehydropirlindole protect neurons against NO-induced toxicity at pharmacologically relevant concentrations. Moreover, their protective effect is still apparent when they are applied after the start of the insult. Therefore, our preclinical study suggests a new strategy that may be efficient to reduce NO-induced damage in the central nervous system. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPhase shift effective range expansion from supersymmetric quantum mechanics
Samsonov, B. F.; Stancu, Floarea ULg

in Physical Review C (2003), 67(5), 054005

Supersymmetric or Darboux transformations are used to construct local phase equivalent deep and shallow potentials for lnot equal0 partial waves. We associate the value of the orbital angular momentum ... [more ▼]

Supersymmetric or Darboux transformations are used to construct local phase equivalent deep and shallow potentials for lnot equal0 partial waves. We associate the value of the orbital angular momentum with the asymptotic form of the potential at infinity, which allows us to introduce adequate long-distance transformations. The approach is shown to be effective in getting the correct phase shift effective range expansion. Applications are considered for the P-1(1) and D-1(2) partial waves of the neutron-proton scattering. [less ▲]

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See detailOsteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells
Barnes, G. L.; Javed, A.; Waller, S. M. et al

in Cancer Research (2003), 63(10), 2631-2637

Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of specific types of cancers remains poorly ... [more ▼]

Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of specific types of cancers remains poorly understood. There is a significant clinical correlation between the expression of bone sialoprotein (BSP) and skeletal metastasis of breast cancers. Our laboratory, as well as others, have proposed the concept that skeletal selective metastasis and associated disease may be attributable to a mimicry of skeletal cellular phenotypes by metastasizing cancer cells. We hypothesize that breast cancer cell expression of phenotypic properties of skeletal cell types, including BSP as one component of that phenotype, is the result of ectopic expression or activity of one or more central transcriptional regulators of bone cell gene expression. To test this hypothesis, we examined the molecular mechanisms that regulate bsp expression in human breast cancer cell lines with previously characterized metastatic potentials. Our results demonstrate that the majority of the distal bsp promoter sequences act to repress BSP expression in cancer cells and that most of the promoter activity resides in the proximal -110 by of the bsp promoter. In this region, we identified a putative Runx binding element providing a basis for a mechanism for skeletal gene activation. Our results demonstrate that Runx2 is ectopically expressed in breast cancer cells and that one isoform of Runx2 can activate bsp expression in these cells. In addition, we observe that bsp expression is additionally regulated by the homeodomain factor Msx2, another regulator of osteoblast-associated genes. Thus, this is the first report of osteoblast-related transcription factors being expressed in human breast cancer cells and provides a component of a mechanism that may explain the osteoblastic phenotype of human breast cancer cells that preferentially metastasize to bone. [less ▲]

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See detailIntermediate basal cells of the prostate: In vitro and in vivo characterization
Garraway, Levi; Lin, Douglas; Signoretti, Sabina et al

in Prostate (2003), 55(3), 206-218

BACKGROUND. Progenitor cells within the prostate basal layer may play important roles in differentiation and carcinogenesis; however, prostate stem cell populations remain uncharacterized. METHODS ... [more ▼]

BACKGROUND. Progenitor cells within the prostate basal layer may play important roles in differentiation and carcinogenesis; however, prostate stem cell populations remain uncharacterized. METHODS. Immunohistochemical and immunoblot analyses were used to characterize prostate epithelial cells (PrEC), a commercially available prostate basal cell isolate. RESULTS. Proliferating PrECs exhibited immunophenotypic characteristics most consistent with basal cells, but during senescence PrECs up-regulated androgen receptor (AR) mRNA, p27, and low-molecular-weight cytokeratin (LMWCK) expression, suggestive of partial differentiation. PrECs also stained strongly for involucrin, which marked a subset of intermediate prostate basal cells in vivo. Basal hyperplasia consisting of involucrin-positive cells was prevalent in prostate tissue from androgen-ablated patients, and formed epithelial clusters flanked by involucrin-negative basal and luminal monolayers. Cultivation of PrECs on matrigel together with androgen-treated stromal conditioned media resulted in dense aggregates, with a peripheral rim of basal-like cells expressing p63 and basal cytokeratins. CONCLUSIONS. PrEC represents an epithelial population whose basal characteristics are modified in response to matrigel, stromal factors, and senescence, consistent with a transient amplifying population. These cells may derive from a previously unrecognized, involucrin-positive subset present in vivo. (C) 2003 Wiley-Liss, Inc. [less ▲]

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See detailLa vie politique belge est un ‘jardin extraordinaire’
Verjans, Pierre ULg

in Courrier international (2003), (n°654), 12-13

Du côté flamand, on vote conservateur, et le Vlaams Blok vampirise le débat politique ; du côté wallon, on penche à gauche, et l'extrême droite semble marginalisée. Le scrutin du 18 mai ne changera pas ... [more ▼]

Du côté flamand, on vote conservateur, et le Vlaams Blok vampirise le débat politique ; du côté wallon, on penche à gauche, et l'extrême droite semble marginalisée. Le scrutin du 18 mai ne changera pas cette donne. [less ▲]

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See detailRadiative lifetime measurements in ErII by time-resolved laser spectroscopy
Xu, H. L.; Jiang, Z. K.; Zhang, Z. G. et al

in Journal of Physics B-Atomic Molecular and Optical Physics (2003), 36(9), 1771-1781

Radiative lifetimes of 30 excited states of Er 11, ranging in energy from 25 592 to 36 148 cm(-1), have been measured by means of a time-resolved laser-induced fluorescence (LIF) technique. Free, singly ... [more ▼]

Radiative lifetimes of 30 excited states of Er 11, ranging in energy from 25 592 to 36 148 cm(-1), have been measured by means of a time-resolved laser-induced fluorescence (LIF) technique. Free, singly ionized erbium ions were produced in a laser-induced plasma. A tunable laser, with 1 ns duration pulse, was employed to selectively excite the Er+ ions. The lifetime values were evaluated from the transient LIF signals recorded by a fast detection system. A comparison of the new results with previously published values is given. HFR calculations, including core-polarization contributions, are found to be in reasonable agreement with experiment, but the present calculations clearly indicate that further laboratory and theoretical work is urgently needed, particularly for the low lying odd configurations of this complex ion. [less ▲]

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See detailIdentification of a continuous structure with a geometrical non-linearity. Part I: Conditioned reverse path method
Kerschen, Gaëtan ULg; Lenaerts, V.; Golinval, Jean-Claude ULg

in Journal of Sound & Vibration (2003), 262(4), 889-906

Particular effort has been spent in the field of identification of multi-degree-of-freedom non-linear systems. The newly developed methods permit the structural analyst to consider increasingly complex ... [more ▼]

Particular effort has been spent in the field of identification of multi-degree-of-freedom non-linear systems. The newly developed methods permit the structural analyst to consider increasingly complex systems. The aim of this paper and a companion paper is to study, by means of two methods, a continuous non-linear system consisting of an experimental cantilever beam with a geometrical non-linearity. In this paper (Part I), the ability of the conditioned reverse path method, which is a frequency domain technique, to identify the behaviour of this structure is assessed. The companion paper (Part II) is devoted to the application of proper orthogonal decomposition, which is an updating technique, to the test example. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailIdentification of a continuous structure with a geometrical non-linearity. Part II: Proper orthogonal decomposition
Lenaerts, V.; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in Journal of Sound & Vibration (2003), 262(4), 907-919

Particular effort has been spent in the field of identification of multi-degree-of-freedom non-linear systems. The newly developed methods permit the structural analyst to consider increasingly complex ... [more ▼]

Particular effort has been spent in the field of identification of multi-degree-of-freedom non-linear systems. The newly developed methods permit the structural analyst to consider increasingly complex systems. The aim of this paper and a companion paper is to study, by means of two methods, a continuous non-linear system consisting of an experimental cantilever beam with a geometrical non-linearity. In the companion paper (Part I) [1] the ability of the conditioned reverse path method, which is a frequency domain technique, to identify the behaviour of this structure-is assessed. This paper (Part II) is devoted to the application of proper orthogonal decomposition, which is an updating technique, to the test example. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailTime correlations and 1/f behavior in backscattering radar reflectivity measurements from cirrus cloud ice fluctuations
Ivanova, K.; Ackerman, T. P.; Clothiaux, E. E. et al

in Journal of Geophysical Research. Atmospheres (2003), 108(D9),

[1] The state of the atmosphere is governed by the classical laws of fluid motion and exhibits correlations in various spatial and temporal scales. These correlations are crucial to understand the short ... [more ▼]

[1] The state of the atmosphere is governed by the classical laws of fluid motion and exhibits correlations in various spatial and temporal scales. These correlations are crucial to understand the short- and long-term trends in climate. Cirrus clouds are important ingredients of the atmospheric boundary layer. To improve future parameterization of cirrus clouds in climate models, it is important to understand the cloud properties and how they change within the cloud. We study correlations in the fluctuations of radar signals obtained at isodepths of winter and fall cirrus clouds. In particular, we focus on three quantities: (1) the backscattering cross-section, (2) the Doppler velocity, and (3) the Doppler spectral width. They correspond to the physical coefficients used in Navier Stokes equations to describe flows, i.e., bulk modulus, viscosity, and thermal conductivity. In all cases we find that power law time correlations exist with a crossover between regimes at about 3 to 5 min. We also find that different type of correlations, including 1/f behavior, characterize the top and the bottom layers and the bulk of the clouds. The underlying mechanisms for such correlations are suggested to originate in ice nucleation and crystal growth processes. [less ▲]

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See detailLes nouveaux antifongiques
Hayette, Marie-Pierre ULg

in Noso-Bulles, bulletin d'information du comité d'hygiène hospitalière et du GGA du CHU de liège (2003)

L'article est une mise au point sur les antifongiques avec leurs indications, toxicité, posologie et critères de remboursement.

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See detailEarly pregnancy diagnosis in sheep by progesterone and pregnancy-associated glycoprotein tests
Karen, A.; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Theriogenology (2003), 59(9), 1941-1948

The aim of this study was to compare the accuracy of the progesterone (P4) and pregnancy associated glycoprotein (PAG) tests for determination of early pregnancy in sheep. Estrus was synchronized in 182 ... [more ▼]

The aim of this study was to compare the accuracy of the progesterone (P4) and pregnancy associated glycoprotein (PAG) tests for determination of early pregnancy in sheep. Estrus was synchronized in 182 Awassi x Merino ewes and blood samples were collected at Days 0 (day of the insemination), 18, 22, 29, 36, and 50 after artificial insemination (AI). Plasma P4 concentrations at Days 0 and 18 were determined by double antibody radioimmunoassay, while PAG concentrations at Days 22, 29, 36 and 50 were determined by a heterologous, double-antibody radioimmunoassay (RIA) using the bovine PAG 67 kDa subunit as tracer and standard and rabbit antiserum raised against a mixture of caprine 55 and 59 kDa PAG subunits as the first antibody. The discriminatory value for diagnosis of pregnancy by the P4 and the PAG-RIA tests was greater than or equal to1 ng/ml. Based on lambing data, the accuracy for diagnosing pregnant (sensitivity) and non-pregnant ewes (specificity) and predictivity of both tests were calculated. The sensitivity, specificity, positive and negative predictive values for P4 and PAG tests were 100, 95.4, 81.6, and 100% at Day 18 (P4) and 93.5, 100, 100 and 98.7% at Day 22 (PAG), respectively. For diagnosis of non-pregnant ewes the PAG test had significantly higher specificity than the P4 test (P < 0.05). It is concluded that ovine pregnancy can be reliably diagnosed at Day 22 after AI by using a heterologous radioimmunoassay of PAG. [less ▲]

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