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See detailVision artificielle et quantification de la forme de pommes
Leemans, Vincent ULg; Magein, Hugo ULg; Destain, Marie-France ULg

in Cahiers Agricultures (1997), 6

Golden delicious apples were characterised automatically by machine vision, taking into account six view of the cheeks and one of the stem end. The Fourier transform of the fruit boundaries were computed ... [more ▼]

Golden delicious apples were characterised automatically by machine vision, taking into account six view of the cheeks and one of the stem end. The Fourier transform of the fruit boundaries were computed and normalised. All the relevant information about the shape was included in the first fifteen harmonics. Moreover, particular harmonics were found to characterise the shape of the Golden delicious variety. By using the amplitude of particular harmonics in a discriminant analysis, apple were sorted into categories defined by EU, with a precision around 96%. The proposed method may also be used to compare varieties objectively, in order to identify relation between physiology and shape. [less ▲]

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See detailOrigine sociale et réussite scolaire : un modèle en Chaîne de Markov estimé sur données individuelles belges
Donni, Olivier; Lejeune, Bernard ULg

in Recherches Economiques de Louvain (1997), 63(4), 421-446

Cet article étudie les relations entre l'origine socio-économique des élèves belges et leur parcours scolaire primaire et secondaire. Il repose sur l'hypothèse que le parcours scolaire des élèves peut ... [more ▼]

Cet article étudie les relations entre l'origine socio-économique des élèves belges et leur parcours scolaire primaire et secondaire. Il repose sur l'hypothèse que le parcours scolaire des élèves peut être décrit par un processus de Markov. Sur la base d'un échantillon transversal d'un millier d'enfants, en fonction de variables socio-économiques et pour chacune des années de scolarité obligatoire, les probabilités individuelles de poursuivre un parcours scolaire ''normal'', c.-à-d. sans redoublement ni relégation dans une filière de second choix, sont estimées. Nos résultats montrent que derrière les substantiels taux agrégés de redoublement qui caractérisent le système scolaire belge se cachent en fait de profondes inégalités sociales. [less ▲]

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See detailKarst non carbonaté au Cameroun méridional. L'exemple des grottes de Mfoula
Willems, Luc ULg; Pouclet, André; Vicat, Jean-Paul

in Würzburger Geographische Arbeiten (1997), 89

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See detailLong-wavelength behavior of the exchange-correlation kernel in the Kohn-Sham theory of periodic systems
Ghosez, Philippe ULg; Gonze, X.; Godby, R. W.

in Physical Review. B : Condensed Matter (1997), 56(20), 12811-12817

The polarization dependence of the exchange-correlation (re) energy functional of periodic insulators within Kohn-Sham (KS) density-functional theory requires a O(1/q(2)) divergence in the re kernel for ... [more ▼]

The polarization dependence of the exchange-correlation (re) energy functional of periodic insulators within Kohn-Sham (KS) density-functional theory requires a O(1/q(2)) divergence in the re kernel for small vectors q. This behavior, exemplified for a one-dimensional model semiconductor, is also observed when an insulator happens to be described asa KS metal, or vice versa. Although it can occur in the exchange-only kernel, it is not found in the usual local, semilocal, or even nonlocal approximations to KS theory. We also show that the test-charge and. electronic definitions of the macroscopic dielectric constant differ from one another in exact KS theory, but are equivalent in the above-mentioned approximations. [less ▲]

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See detail67-kD laminin receptor expression correlates with worse prognostic indicators in non-small cell lung carcinomas.
Fontanini, G.; Vignati, S.; Chine, S. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1997), 3(2), 227-31

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67 ... [more ▼]

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67-kDa laminin receptor. Sixty-one of 72 patients (84.7%) displayed a MLuC5-positive reaction, which was usually localized in both the inner surface of the plasmatic membranes and the cytoplasm of neoplastic cells. When we compared the laminin receptor expression with clinicopathological and biological parameters such as histotype, grading, T status, N status, ploidy, proliferative activity, vessel invasion, and p53 protein accumulation, the following results were observed: (a) the mean expression of the receptor was higher in the group of patients with metastatic nodal involvement than in those with uninvolved lymph nodes (P = 0.02); (b) a high Ki-67 score (>13% of positive cells) was observed in tumors with a higher mean value of laminin receptor (P = 0.004); (c) the tumors harboring neoplastic emboli in their vessels showed a higher laminin receptor immunoreactivity (P = 0.02); and (d) a borderline association was found between the high mean value of laminin receptor immunopositivity and p53 accumulation in neoplastic cell nuclei (P = 0.05). Our observations indicate that detection of high tissue levels of 67-kDa laminin receptor is associated with an invasive phenotype in non-small cell lung cancer and may provide further information in the biological characterization of this type of cancer. [less ▲]

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See detailUn cas de néoténie dans un bâtiment désaffecté, chez le Triton alpestre, Triturus alpestris apuanus (Salamandridae)
Denoël, Mathieu ULg

in Alytes (1997), 15

A population of Triturus alpestris apuanus of the Apuane Alps (Tuscany , Italy) was studied during July 1994. The particularity of this population is that it breeds in an artificial site, in the dark and ... [more ▼]

A population of Triturus alpestris apuanus of the Apuane Alps (Tuscany , Italy) was studied during July 1994. The particularity of this population is that it breeds in an artificial site, in the dark and under cover, in a deserted building. Moreover some neotenic newts were discovered. The recent colonization and the instability of this biotope indicate a form of labile neoteny, appearing and disappearing spontaneously. [less ▲]

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See detailLes bacs à graisse : une solution aux problèmes des matières grasses pour les PME
Thonart, Philippe ULg; Destain, Jacqueline ULg; Zgoulli, S. et al

in Tribune de l'Eau (La) (1997), 586/2

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See detailEtude comparative de la décontamination microbiologique, avec ou sans Biosol, de terres d'excavation contaminées par des hydrocarbures
Verstaete, W.; Van Eyck, L.; Thonart, Philippe ULg et al

in Tribune de l'Eau (La) (1997), 587/3

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See detailDesign for an Ipriflavone Multicenter European Fracture Study
Reginster, Jean-Yves ULg; Bufalino, L.; Christiansen, C. et al

in Calcified Tissue International (1997), 61(Suppl 1), 28-32

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large ... [more ▼]

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large multicentric European study was designed and is presently ongoing. Included in the study were 460 Caucasian, nonobese postmenopausal women aged > 45 and < 75 years, menopaused for at least 12 months. Inclusion was on the basis of a lumbar bone mineral density (BMD) lower than 2 SD compared with healthy women aged 50 years, corresponding to values below 0.860 g/cm2 (antero-posterior measurement) by Hologic QDR 1000. Women with prevalent vertebral fractures were excluded as well as those presenting secondary osteoporosis or having been treated with medications that could affect bone metabolism. This study was designed as a 3-year, double-blind, placebo-controlled, parallel group study that randomized the women to the oral administration of either 3 x 200 mg/day of i.p. or placebo. All patients received a daily supplement of 500 mg calcium. The primary purpose of the study was to evaluate the efficacy of i.p. in preventing vertebral nontraumatic fractures. Fracture is defined here as a > or = 20% decrease in any anterior, central, or posterior T4-L4 vertebral height. Blinded vertebral X-ray readings and vertebral morphometry have been centralized in an independent Center, with standardized evaluation of two experts. Power calculations have been based on the hypothesis that 21% of placebo-treated patients would fracture within 3 years and that treatment with i.p. would lead to a 50% reduction in the incidence of fracture. Statistical tests have been designed to have a power of 80%, with a type I error equal to 5%. Secondary endpoints were changes in vertebral, radial, and femoral BMD. Centralized controls on 100% BMD scans would ensure the good quality of BMD readings. This study should verify the hypothesis that i.p. significantly decreases the risk of vertebral fracture in postmenopausal, osteoporotic women. [less ▲]

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See detailLes peuplements à graines. Concept, réglementations et mise en oeuvre.
Vanslembrouck, C.; Rondeux, Jacques ULg

in Silva Belgica (1997), 104(4), 17-21

La rentabilité de la propriété forestière qui, dans une large mesure, conditionne la pérennité des forêts gérées intensivement fait de plus en plus l'objet des préoccupations des chercheurs, sylviculteurs ... [more ▼]

La rentabilité de la propriété forestière qui, dans une large mesure, conditionne la pérennité des forêts gérées intensivement fait de plus en plus l'objet des préoccupations des chercheurs, sylviculteurs, gestionnaires et responsables des politiques forestières. Dans ce contexte, lorsqu'il s'agit de la création et de l'enrichissement de peuplements, veiller à respecter la meilleure adéquation possible entre le sol et l'essence n'est pas tout, encore faut-il ensuite utiliser un matériel génétique de qualité en particulier lors de régénérations artificielles. C'est à ce dernier point, et plus particulièrement aux peuplements à graines, que les lignes suivantes sont consacrées. Nous envisagerons successivement ce qu'il convient communément d'entendre par peuplement à graines (§ 2), sa raison d'être (§ 3) et le processus d'identification de celui-ci (§ 4) avant de tirer quelques brèves conclusions. [less ▲]

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See detailThe TEL gene products: nuclear phosphoproteins with DNA binding properties.
Poirel, H.; Oury, Cécile ULg; Carron, Clémence et al

in Oncogene (1997)

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute ... [more ▼]

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events. [less ▲]

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See detailRadiation therapy duration influences overall survival in patients with cervix carcinoma.
Coucke, Philippe ULg; Delaloye, J-F; Pampallona, S et al

in International Journal of Gynecology & Obstetrics (1997), 57

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation ... [more ▼]

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to the duration of the therapies, taking 60 days (the 75th percentile) as an arbitrary cut-off. Results: The 5-year survival was 61% (SE. = 3%) for the therapy duration group of less than 60 days and 53% (SE. = 7%) for the group of more than 60 days. In terms of univariate hazard ratio (HR), the relative difference between the hvo groups corresponds to a 50% increase of deaths (HR = 1.53, 95% CI = 1.03-2.28) for the longer therapy duration group (P = 0.044). In a multivariate analysis, the magnitude of estimated relative hazards for the longer therapies are confirmed though significance was reduced (HR = 1.52, 95% CI = 0.94-2.45, P = 0.084). Conclusion: These findings suggesthat short treatment duration is a factor associated with longer survival in carcinoma of the cervix. 0 1997 International Federation of Gynecology and Obstetrics [less ▲]

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See detailTrajectoire déviante à la lisière entre adolescence et âge adulte
Gavray, Claire ULg

in Déviance et Société (1997), 21(3), 273-288

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See detailNos élèves préfèrent Pythagore à Newton
Monseur, Christian ULg

in Pilotinfo (1997), 20(septembre),

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See detailcDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.
Colige, Alain ULg; Li, S. W.; Sieron, A. L. et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94(6), 2374-9

Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and ... [more ▼]

Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and sheep, and they cause type VIIC Ehlers-Danlos syndrome in humans, heritable disorders characterized by accumulation of pNcollagen and severe skin fragility. Amino acid sequences for the N-proteinase were used to obtain cDNAs from bovine skin. Three overlapping cDNAs had an ORF coding for a protein of 1205 residues. Mammalian cells stably transfected with a complete cDNA secreted an active recombinant enzyme that specifically cleaved type I procollagen. The protein contained zinc-binding sequences of the clan MB of metallopeptidases that includes procollagen C-proteinase/BMP-1. The protein also contained four repeats that are homologous to domains found in thrombospondins and in properdin and that can participate in complex intermolecular interactions such as activation of latent forms of transforming growth factor beta or the binding to sulfatides. Therefore, the enzyme may play a role in development that is independent of its role in collagen biosynthesis. This hypothesis was supported by the observation that in some tissues the levels of mRNA for the enzyme are disproportionately high relative to the apparent rate of collagen biosynthesis. [less ▲]

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See detailAssessment of pain in herpes zoster: lessons learned from antiviral trials
Dworkin, R. H.; Carrington, D.; Cunningham, A. et al

in Antiviral Research (1997), 33(2), 73-85

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but ... [more ▼]

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review, recommendations for the design and analysis of future trials of antiviral agents in herpes zoster are proposed. The principal recommendation is that antiviral efficacy should be evaluated both by distinguishing post-herpetic neuralgia from acute pain and by considering pain as a continuum. The primary endpoint should address both the prevalence and duration of post-herpetic neuralgia and should be examined in those patients who have post-herpetic neuralgia. Adopting the proposed recommendations in design and analysis of future trials should facilitate comparison across trials of the efficacy of antiviral agents in the treatment of herpes zoster. [less ▲]

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See detailPhenylarsine oxide inhibits ex vivo HIV-1 expression
Edeas, M.; Arbault, S.; Legrand-Poels, Sylvie ULg et al

in Biomedicine & Pharmacotherapy (1997)

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See detailHiggs boson search at photon collider for M(h) = 140-GeV - 190-GeV
Ginzburg, I. F.; Ivanov, Igor ULg

in Physics Letters B (1997), 408

A Higgs boson within the mass range $M_H=140-190$ GeV can be discovered at a photon collider in the reaction $\gamma\gamma\to WW$ (with real or virtual W) with the luminosity integral about 1 fb$^{-1 ... [more ▼]

A Higgs boson within the mass range $M_H=140-190$ GeV can be discovered at a photon collider in the reaction $\gamma\gamma\to WW$ (with real or virtual W) with the luminosity integral about 1 fb$^{-1}$. The reasonable resolution in the effective mass of the WW system is required. [less ▲]

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See detailOn endostyle ultrastructure in two new species of doliolid-like tunicates
Compère, Philippe ULg; Godeaux, Jean

in Marine Biology (1997), 128

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See detailMecanisme de croissance et de rupture des anevrysmes de l'aorte abdominale.
Limet, Raymond ULg; SakalihasanN, Natzi ULg; Lapiere, C. M.

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1997), 152(7-9), 295-302302-3

The relationship between atherosclerosis and abdominal aortic aneurysm development is well known. Atherosclerosis cannot explain the whole mechanism. Genetic characters of mechanisms leading to abdominal ... [more ▼]

The relationship between atherosclerosis and abdominal aortic aneurysm development is well known. Atherosclerosis cannot explain the whole mechanism. Genetic characters of mechanisms leading to abdominal aortic development is obvious from this study and others. Our study evidences an increased metalloproteases activity in aortic wall proportionally to the size of the abdominal aortic aneurysm. A decrease of aortic wall elastin is evidenced proportionally to the AAA size. Extractable collagen is significantly increased in the aortic wall of patients operated on for aortic rupture. [less ▲]

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See detailUse of recombinant human erythropoietin after allogeneic bone marrow transplantation
Hermanne, J.-P.; Beguin, Yves ULg

in Erythropoiesis (1997), 8

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See detailA propos de quelques utilisations non conventionnelles de la metformine
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (1997), 55

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See detailFibres alimentaires chez le chien : influence de l'incorporation de pulpes de betterave ou de chicorée sur la digestibilité des nutriments et les concentrations plasmatiques de plusieurs métabolites
Diez, Marianne ULg; Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg et al

in Revue de Médecine Vétérinaire (1997), 148

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres ... [more ▼]

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres fécaux, la digestibilité des principaux nutriments et plusieurs paramètres biochimiques (glucose, insuline, azote alpha-aminé, urée, cholestérol et triglycérides) mesurés à jeun ou pendant six heures après le repas chez huit chiens adultes en bonne santé. Les régimes enrichis en pulpes ont entraîné une augmentation significative de l'excrétion fécale totale, de l'excrétion de MS dans les matières fécales, une diminution de la teneur en MS des fèces ainsi qu'une diminution des coefficients de digestibilité des principaux nutriments. Le régime contenant la pulpe de betterave a entraîné une diminution de la glycémie à jeun, de l'insulinémie et des concentrations en triglycérides postprandiales, des concentrations en urée et en cholestérol mesurées avant et après le repas. Le régime contenant la pulpe de chicorée a provoqué une diminution de l'insulinémie postprandiale, des concentrations en urée et en cholestérol à jeun et après le repas. Ces deux types de pulpes, semblables par leur composition, induisent les mêmes types d'effets sur les paramètres fécaux et la digestibilité des nutriments, mais les effets systémiques sont plus importants lors de la distribution de pulpes de betterave. [less ▲]

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See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailImpaired LTP induction in dentate gyrus of calretinin-deficient mice
Schurmans, Stéphane ULg; Schiffmann, S. N.; Gurden, H. et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94

Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting ... [more ▼]

Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting and have investigated the associated phenotype. Cr2/2 mice were viable, and a large number of morphological, biochemical, and behavioral parameters were found unaffected. In the normal mouse hippocampus, Cr is expressed in a widely distributed subset of GABAergic interneurons and in hilar mossy cells of the dentate gyrus. Because both types of cells are part of local pathways innervating dentate granule cells andyor pyramidal neurons, we have explored in Cr2/2 mice the synaptic transmission between the perforant pathway and granule cells and at the Schaffer commissural input to CA1 pyramidal neurons. Cr2/2 mice showed no alteration in basal synaptic transmission, but long-term potentiation (LTP) was impaired in the dentate gyrus. Normal LTP could be restored in the presence of the GABAA receptor antagonist bicuculline, suggesting that in Cr2/2 dentate gyrus an excess of g-minobutyric acid (GABA) release interferes with LTP induction. Synaptic transmission and LTP were normal in CA1 area, which contains only few Cr-positive GABAergic interneurons. Cr2/2 mice performed normally in spatial memory task. These results suggest that expression of Cr contributes to the control of synaptic plasticity in mouse dentate gyrus by indirectly regulating the activity of GABAergic interneurons, and that Cr2/2 mice represent a useful tool to understand the role of dentate LTP in learning and memory [less ▲]

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See detailAppraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines.
Monroe, E. W.; Daly, Adrian ULg; Shalhoub, R. F.

in Journal of Allergy and Clinical Immunology (The) (1997), 99(2), 798-806

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and ... [more ▼]

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and the number of newer drugs available for clinical use is growing. Various methods have been used to assess antihistaminic activity, the most popular of which is the epicutaneous histamine-induced wheal and flare. This test relies on the ability of epicutaneously injected histamine to bring about the wheal and flare, a neurovascular response that involves reflex vasodilation (flare) and local swelling caused by plasma extravasation (wheal). Antihistamines have been compared on the basis of their ability to block the histamine-induced wheal and flare in the skin. Results of these trials have been applied to predict the global antiallergic efficacy of various antihistamines. The review has examined the reliability of suppression of the histamine wheal and flare reaction in the skin to predict an antihistamine's clinical efficacy in two common allergic diseases seasonal allergic rhinitis and chronic idiopathic urticaria. Although histamine is one mediator in the allergic response in the skin and nasal mucosa, many other agents are important modulators of the allergic response. In addition, the major structural and functional differences that exist between the nasal mucosa and the skin affect the type of local response. These manifest themselves as differences between the responses to antigen and histamine challenge in the skin and the nose. The allergic responses in these tissues are not simply the consequence of one chemical but are the result of a cascade of interactions among various cells and mediators. The clinical manifestations of these complex interactions obviously cannot be fully replicated by injection of one chemical mediator, histamine, into the outer layer of the skin. Studies with antihistamines have shown that certain drugs, such as cetirizine, are more suppressive than others (loratadine, terfenadine) in controlling the histamine-induced wheal and flare reaction in the skin. When the clinical efficacy of these medications is compared in clinical trials in seasonal allergic rhinitis and chronic idiopathic urticaria, all are equally efficacious in controlling symptoms. Although the histamine-induced wheal and flare reaction can serve as a useful clinical pharmacologic test to assess dose-response relations for an antihistamine, its lack of correlation with clinical responses among antihistamines indicates that this model should not be used to predict or compare clinical efficacies of antihistamines in seasonal allergic rhinitis and chronic idiopathic urticaria. [less ▲]

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See detailRisultati clinici ed angiografici immediati ed a lungo termine dello stent Wiktor nel trattamento delle occlusioni coronariche croniche.
Anzuini, A.; Rosanio, S.; Legrand, Victor ULg et al

in Giornale italiano di cardiologia (1997), 27(9), 881-91

BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) of chronic total coronary artery occlusions is associated with very high restenosis and reocclusion rates. Coronary stenting has been ... [more ▼]

BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) of chronic total coronary artery occlusions is associated with very high restenosis and reocclusion rates. Coronary stenting has been proposed as a means of improving outcome. However, the Wiktor device for chronic coronary occlusion has never been tested in a large patient sample. This study reports the first multicenter experience with the Wiktor stent for treatment of chronic occlusions. METHODS: From January 1993 to December 1996, 89 consecutive patients with 91 chronic occlusions underwent Wiktor stent implantation after successful PTCA. Post-stenting regimen consisted of coumadin plus aspirin in the first 49 (55%) patients and aspirin plus ticlopidine in the following 40 (45%). RESULTS: Stenting was successful in 87 (98%) patients. At 1 month, 6% of patients had subacute stent thrombosis, 1% access-site complications and 3% major bleeding events. Stent thrombosis showed a univariate association with coumadin therapy (p = 0.009). Angiographic follow-up was obtained in 93% of 82 eligible patients. Restenosis rate was 32%, including 4% reocclusions. Through multiple logistic regression analysis, restenosis was independently associated with multiple stents (odds ratio-OR = 27.67, 95% confidence interval-CI = 4.25 to 79.95, p = 0.0008) and increasing values of occlusion length (OR = 1.23, 95% CI = 1.09 to 1.39, p = 0.001). Freedom from death, myocardial infarction or stented vessel revascularization was 87 and 72% at one and three years, respectively. CONCLUSIONS: Short- and long-term clinical and angiographic outcomes are favorable in patients undergoing Wiktor stent implantation for chronic coronary occlusion. Further technical refinements are needed to reduce restenosis rate in patients with long lesions and multiple stents. [less ▲]

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See detailMise au point d'une technique de culture in vitro d'embryons immatures de Phaseolus.
Mergeai, Guy ULg; Schmit, V.; Baudoin, Jean-Pierre ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(1),

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See detailPolyclonal Bovine Sera But Not Virus-Neutralizing Monoclonal Antibodies Block Bovine Leukemia Virus (Blv) Gp51 Binding To Recombinant Blv Receptor Blvrcp1
Orlik, O.; Ban, J.; Hlavaty, J. et al

in Journal of Virology (1997), 71(4),

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See detailAbdominal sequelae after pedicled TRAM flap breast reconstruction
PETIT, JY; RIETJENS, M; FERREIRA, M et al

in Plastic and Reconstructive Surgery (1997), 99

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants ... [more ▼]

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants. Although such enthusiasm for the transverse rectus abdominis musculocutaneous (TRAM) flap is justified in what concerns the final cosmetic result of the reconstructed breast, the risk of abdominal sequelae should be explained to the patient. Abdominal scarring, parietal weakness, strength loss, and back pain have been recorded in a series of pedicled TRAM flap reconstructions performed at the Institut Gustave-Roussy before 1991. Cosmetic results of the abdomen were tested by three independent judges on the photographs taken of 132 patients. The global appearance of the abdomen was rated as "natural" in 70 percent of the patients. The umbilical scar was unacceptable in 25 percent and very good or not visible in 21 percent. The lower abdominal scar was rated as "not acceptable" in 35 percent. Abdominal strength was tested among the 38 patients who underwent both preoperative and postoperative muscular testing, of whom 18 had single-pedicled and 20 had bipedicled TRAM flap reconstructions. In the first group, the physiotherapist observed an impairment of function of the upper portion of the rectus abdominis and of the oblique muscle in almost 50 percent. In the second group, the same muscles were more severely impaired (in 60 percent), as well as the function of the lower portion of the rectus (in 15 percent). The percentage of patients complaining of "light back pain" in the 6-month postoperative period was 55 percent in the single-pedicle group and 30 percent in the double-pedicle group. However, 20 percent of the bipedicled patients complained of "severe" back pain, while there was none in the single-pedicled group. In conclusion, abdominal sequelae after TRAM flap breast reconstruction should not be underestimated and constitute one of the drawbacks of the technique when it is compared with reconstruction with a prosthesis. [less ▲]

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See detailFluidothérapie parentérale pratique chez les bovins
Rollin, Frédéric ULg

in Annales de Médecine Vétérinaire (1997), 141(2), 89-111

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte ... [more ▼]

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte disturbances and glycemia. The various classes of fluids are then considered as a function of the indications. Use of transfusion, hypertonic solutions and parenteral nutrition is broached. Routes and techniques of fluid administration are detailed. Obstacles encountered by the bovine practitioner when using parenteral fluid therapy are emphasized just as the means to overcome them. In this regard, it is described how to correctly prepare fluids for suited parenteral use in cattle. In fact, the present laws do not given this allowance to the practitioners. However, in most cases, it constitutes the only economical option avoiding worthless sufferings and death of the animal. [less ▲]

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See detailPEGASE, une méthodologie et un outil de simulation prévisionnelle pour la gestion de la qualité des eaux de surface
Smitz, Joseph ULg; Everbecq, Etienne ULg; Deliège, Jean-François ULg et al

in Tribune de l'Eau (La) (1997), 50/4(588), 73-82

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle ... [more ▼]

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle la qualité des eaux des rivières en fonction des rejets et apports de pollution. PEGASE est un outil opérationnel permettant d’orienter les choix des opérateurs publics et privés en matière de gestion des eaux de surface à l’échelle des bassins versants [less ▲]

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See detailCharacterization of non pigmented B16 melanoma cell-derived cytotoxic factors.
Siwek, B.; De Pauw, Marie-Claire ULg; Quetin-Leclercq, J. et al

in Chemico-Biological Interactions (1997), 103(1), 59-73

We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests ... [more ▼]

We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests used showed that ultrafiltrated conditioned media (CM U1 fraction) contained several cytotoxic factors with a Mw lower than 1000 Da. These factors seemed to act either directly or indirectly on cell membranes, mitochondria, on the cell cycle and on protein and DNA synthesis. A cytotoxic activity could be found even after high dilution of CM U1. These cytotoxic factors were rapidly released by B16 cells in culture, independently of cell confluence. Their activities in the treated cells were also very fast and the cytotoxic effects were irreversible after only a few hours of treatment. These factors were not intermediate products during melanogenesis, neither polyamines, nor proteases. At least one of them seemed to be a small acidic and basic stable peptide without disulfide bounds but not heat stable. The synthesis of at least one of these cytotoxic factors was inhibited by cycloheximide and the cytotoxic activity was partially destroyed by pronase and trypsin, but not by pepsin. The cytotoxicity was not modified by copper complexants or free radical inhibitors (bovine serum albumin (BSA), tyrosine, superoxyde dismutase (SOD), catalase, vitamin E). Furthermore the levels of glutathione peroxydase activity and reduced glutathione did not change after treatment by CM U1 as compared to controls. [less ▲]

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See detailFibres alimentaires chez le chien III. Effets sur les structures intestinales et les fermentations. Applications dans le traitement de certains dysfonctionnements intestinaux
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

Dietary fibres can modify the intestinal structure in dogs and other animal species. The main changes concern not only the morphology of the gastrointestinal tract but also the ultrastructures ... [more ▼]

Dietary fibres can modify the intestinal structure in dogs and other animal species. The main changes concern not only the morphology of the gastrointestinal tract but also the ultrastructures. Furthermore, soluble and partly-soluble fibres are fermented in the large bowel; the fermentation products have different metabolic effects. The physical and chemical properties of fibres can be used for the dietary therapy of some intestinal pathologies [less ▲]

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See detailCompte rendu de VAUCHEZ (A.), La spiritualité du Moyen Age occidental VIIIe-XIIIe siècle, Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailRectovaginal septum adenomyotic nodules: a series of 500 cases.
Donnez, Jacques; NISOLLE, Michelle ULg; Gillerot, Stépane et al

in British Journal of Obstetrics & Gynaecology (1997), 104(9), 1014-8

OBJECTIVE: Laparoscopic procedure with excision of deep fibrotic endometriotic nodules of the rectovaginal septum and histological study of the lesions. SETTING: An academic teaching hospital ... [more ▼]

OBJECTIVE: Laparoscopic procedure with excision of deep fibrotic endometriotic nodules of the rectovaginal septum and histological study of the lesions. SETTING: An academic teaching hospital. PARTICIPANTS: A series of 500 women undergoing laparoscopy for pelvic pain or infertility. RESULTS: Laparoscopic (n = 497) and laparotomic (n = 3) excision of endometriotic nodules resulted in considerable pain relief. Histologically the rectovaginal nodule was similar to an adenomyoma as it was a circumscribed nodular aggregate of smooth muscle and endometrial glands and stroma. The variations in oestrogen receptor and progesterone receptor content suggested a regulatory mechanism different from that of eutopic endometrium. CONCLUSION: This form of disease should be considered as an entity distinct from peritoneal and ovarian endometriosis, and originating from the Müllerian rests present in the rectovaginal septum. [less ▲]

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See detailBounds on the Soft Pomeron Intercept
Cudell, Jean-René ULg; Kang, Kyungsik; Kim, Sung Ku

in Physics Letters B (1997), 395

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See detailLes lipoxygénases du soja.
Fauconnier, Marie-Laure ULg; Marlier, M.

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(2), 125-141

Dans cet article de synthèse, les auteurs font le point sur les connaissances actuelles dans le domaine des lioxygénases du soja. Une attention particulière est portée à la compréhension des mécanismes ... [more ▼]

Dans cet article de synthèse, les auteurs font le point sur les connaissances actuelles dans le domaine des lioxygénases du soja. Une attention particulière est portée à la compréhension des mécanismes réactionnels (substrats, inhibiteurs, site actif, etc.). Le rôle physiologique ainsi que l'utilisation de cet enzuyme dans les industries agroalimentaires et en biotechnologie sont également abordés. [less ▲]

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See detailUne chambre noire pour l’analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1997), 33

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See detailEpilepsies rebelles de l'enfant: définition et modalités de prise en charge hospitalière
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Neurone (1997), 2(8), 285-288

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See detailModulation of lung inflammation in the control of bovine respiratory disease
Van de Weerdt, ML; Lekeux, Pierre ULg

in Bovine Practitioner (1997), 31.1

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible ... [more ▼]

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible preventive treatments will not be discussed in this review. [less ▲]

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See detailFibres alimentaires chez le chien II. Effets sur la vidange gastrique et le transit gastro-intestinal
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is ... [more ▼]

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is also given. The incorporation of fibres in the diet is one of many other factors which influence the mechanisms of emptying in the gastrointestinal tract. The effect of dietary fibres is also discussed in other monogastric species [less ▲]

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See detailTotal cholesterol levels during adolescence: results of a Belgian MONICA population
Paulus, D.; Saint-Remy, Annie ULg; Rorive, Georges ULg et al

in Acta Cardiologica (1997), 52(2), 182-183

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See detail(Meth)acrylates pseudo-living radical polymerization in the presence of transition metal complexes: the Kharasch reaction revisited
Granel, Claude; Moineau, George; Lecomte, Philippe ULg et al

in Polymer Preprints (1997), 38(1), 450-451

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See detailIntroduction à l'analyse des données par le logiciel Minitab sous Windows
Claustriaux, Jean-Jacques ULg

in Notes de Statistique et d'Informatique (1997), (2), 1-22

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See detailL'art et le corps
Duchesne, Jean-Patrick ULg

in Art&fact (1997), 16

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See detailFloctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs
Lequesne, M; Fannius, J; Reginster, Jean-Yves ULg et al

in Revue du Rhumatisme (English ed.) (1997), 64(5), 327-333

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See detailClostridium spiroforme toxin genes are related to C. perfringens iota toxin genes but have a different genomic localization.
Gilbert, M.; Perelle, S.; Daube, Georges ULg et al

in Systematic & Applied Microbiology (1997), 20

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See detailThe lowest 5g-6h supermultiplet of Fe II
Biémont, Emile ULg; Johansson, S.; Palmeri, P.

in Physica Scripta (1997), 55

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See detailLa Belgique: Diversité territoriale
Merenne-Schoumaker, Bernadette ULg; Van der Haegen, H.; Van Hecke, E.

in Bulletin du Crédit Communal (1997), (202), 144

Présentation synthétique en 16 thèmes des résultats des recherches d'équipes universitaires de la KULeuven, l'UCL, l'ULB, la VUB et l'ULg. Tableau de la situation de la Belgique en 1991 et des dynamiques ... [more ▼]

Présentation synthétique en 16 thèmes des résultats des recherches d'équipes universitaires de la KULeuven, l'UCL, l'ULB, la VUB et l'ULg. Tableau de la situation de la Belgique en 1991 et des dynamiques entre 1981 et 1991. 155 cartes en couleurs. [less ▲]

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See detailSarcoidosis: recognition and treatment guidelines
Kaye, O.; Ribbens, Clio ULg; Kahn, M. F. et al

in BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals & Gene Therapy (1997), 7(6), 441-447

Sarcoidosis is a systemic disorder of unknown aetiology characterised by noncaseating granulomas leading principally to bilateral hilar lymphadenopathies, pulmonary infiltration and skin and eye lesions ... [more ▼]

Sarcoidosis is a systemic disorder of unknown aetiology characterised by noncaseating granulomas leading principally to bilateral hilar lymphadenopathies, pulmonary infiltration and skin and eye lesions. Sarcoidosis may involve other organs, including peripheral lymph nodes, liver, spleen, nervous and musculoskeletal systems, heart, ear, nose and kidney. Although the clinical involvement of liver and heart is relatively uncommon, hepatic and cardiac granulomas are present at autopsy in about 70 to 80% and 25 to 50%, respectively, of patients with this disease. The diagnosis of sarcoidosis includes compatible clinical and/or radiological presentations and histological evidence of noninfectious and noncaseating epitheloid cell granulomas in the absence of other identifiable agents responsible for such histological lesions. Disease course is variable and usually characterised by frequent remissions, but it may become progressive and chronic in a small percentage of patients. The optimal treatment of sarcoidosis remains poorly defined. In patients with progressive pulmonary dysfunction as well as in those with severe extrapulmonary localisations, systemic corticosteroids usually represent the first approach, limited by long term toxicity and frequent relapses after treatment interruption. In the presence of refractory or corticosteroid-dependent forms of the disease, antimalarial drugs or low dosage methotrexate may be used with prolonged benefit. The indications for immunosuppressive agents such as azathioprine, chlorambucil, cyclophosphamide and cyclosporin are uncommon and limited because of potentially serious adverse effects and lack of information on their long term efficacy. In the case of ocular and limited cutaneous manifestations, local corticosteroid therapy may be useful. [less ▲]

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See detailDifferential expression of c-fos, Hsp70 and Hsp27 after photothrombotic injury in the rat brain.
Plumier, Jean-Christophe ULg; Armstrong, J. N.; Wood, N. I. et al

in Molecular Brain Research (1997), 45(2), 239-46

In situ hybridization and immunohistochemistry were used to examine the expression of c-fos, Hsp70 and Hsp27 following photothrombotic injury in the right fronto-parietal cortex of the rat. C-fos mRNA and ... [more ▼]

In situ hybridization and immunohistochemistry were used to examine the expression of c-fos, Hsp70 and Hsp27 following photothrombotic injury in the right fronto-parietal cortex of the rat. C-fos mRNA and protein were detected in the entire cerebral cortex on the lesioned side. Hsp70 mRNA accumulation was observed only adjacent and peripheral to the site of the lesion. At 1 h after photothrombotic injury, Hsp70 expression delineates the area of necrosis at 24 h after photothrombotic injury. Hsp27 protein was observed in the ipsilateral cerebral cortex with the exception of the deep layers of the cingulate cortex. In addition, while c-Fos immunoreactivity was localized in cell nuclei, Hsp27 immunoreactivity was detected in the cytoplasm of astrocytes. These results demonstrate that unilateral cortical injury induces changes in gene expression that vary according to cell type and brain region. [less ▲]

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See detailCompte rendu de Moines et religieux au Moyen Age, éd. BERLIOZ (J.), Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailImprovement of inland navigation in developping countries: the training center of Palembang (Sumatra, Indonesia), an example of transfer of technology through education
Marchal, Jean ULg

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (1997), Nouvelle Série 42(4)(1er trimestre), 10

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See detailActivation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells
Legrand-Poels, Sylvie ULg; Maniglia, Salvator; Boelaert, J. R. et al

in Biochemical Pharmacology (1997)

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See detailRelative and absolute in Leibniz' physics and metaphysics
Bouquiaux, Laurence ULg

in Epistemologia (1997)

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See detailRégime et tactique alimentaires de la loutre (Lutra lutra) dans le Massif Central
Libois, Roland ULg

in Vie et milieu (1997), 47(1), 33-45

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback ... [more ▼]

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback, gudgeon and minnow) are the most numerous items in the diet: they account for more than 50% of the 3,148 identified preys. However, when expressed in relative biomass, their importance falls down (8 %). In fact, the brown trout, large cyprinid fish, birds and mammals make up the bulk of the diet. We found strong differences linked to the general habitat types and also seasonal ones. Frogs are mainly preyed upon during the spring whereas the snakes are exclusively taken in the summer and autumn months. Gudgeon and insects are also mainly summer and autumn preys. Perch and large cyprinid fish remais are more frequent during winter and even spring. The present results confirm the opportunistic way of predation of the otter and the fact that its hunting takes place more on the bottom and along the river banks than in the open water. [less ▲]

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See detailFibres alimentaires chez le chien : VII. Intérêt dans le traitement diététique de l'animal obèse
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The present review deals with obesity in the dog, Definition, incidence, assessment, etiology and detrimental effects of obesity are firstly presented. In a second part, the treatment is discussed, with ... [more ▼]

The present review deals with obesity in the dog, Definition, incidence, assessment, etiology and detrimental effects of obesity are firstly presented. In a second part, the treatment is discussed, with particular emphasis on the incorporation of large quantities of dietary fibres in low-energy specific purpose food. At present time, no conclusions can be drawn from published studies [less ▲]

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See detailOrderly process of sequential cytokine stimulation is required for activation and maximal proliferation of primitive human bone marrow CD34+ hematopoietic progenitor cells residing in G0.
Ladd, A. C.; Pyatt, R.; GOTHOT, André ULg et al

in Blood (1997), 90(2), 658-68

Bone marrow (BM) CD34+ cells residing in the G0 phase of cell cycle may be the most suited candidates for the examination of cell cycle activation and proliferation of primitive hematopoietic progenitor ... [more ▼]

Bone marrow (BM) CD34+ cells residing in the G0 phase of cell cycle may be the most suited candidates for the examination of cell cycle activation and proliferation of primitive hematopoietic progenitor cells (HPCs). We designed a double simultaneous labeling technique using both DNA and RNA staining with Hoechst 33342 and Pyronin Y, respectively, to isolate CD34+ cells residing in G0(G0CD34+). Using long-term BM cultures and limiting dilution analysis, G0CD34+ cells were found to be enriched for primitive HPCs. In vitro proliferation of G0CD34+ cells in response to sequential cytokine stimulation was examined in a two-step assay. In the first step, cells received a primary stimulation consisting of either stem cell factor (SCF), Flt3-ligand (FL), interleukin-3 (IL-3), or IL-6 for 7 days. In the second step, cells from each group were washed and split into four or more groups, each of which was cultured again for another week with one of the four primary cytokines individually, or in combination. Tracking of progeny cells was accomplished by staining cells with PKH2 on day 0 and with PKH26 on day 7. Overall examination of proliferation patterns over 2 weeks showed that cells could progress into four phases of proliferation. Phase I contained cytokine nonresponsive cells that failed to proliferate. Phase II contained cells dividing up to three times within the first 7 days. Phases III and IV consisted of cells dividing up to five divisions and greater than six divisions, respectively, by the end of the 14-day period. Regardless of the cytokine used for primary stimulation, G0CD34+ cells moved only to phase II by day 7, whereas a substantial percentage of cells incubated with SCF or FL remained in phase I. Cells cultured in SCF or FL for the entire 14-day period did not progress beyond phase III but proliferated into phase IV (with <20% of cells remaining in phases I and II) if IL-3, but not IL-6, was substituted for either cytokine on day 7. G0CD34+ cells incubated with IL-3 for 14 days proliferated the most and progressed into phase IV; however, when SCF was substituted on day 7, cells failed to proliferate into phase IV. Most intriguing was a group of cells, many of which were CD34+, detected in cultures initially stimulated with IL-3, which remained as a distinct population, mostly in G0/G1, unable to progress out of phase II regardless of the nature of the second stimulus received on day 7. A small percentage of these cells expressed cyclin E, suggesting that their proliferation arrest may have been mediated by a cyclin-related disruption in cell cycle. These results suggest that a programmed response to sequential cytokine stimulation may be part of a control mechanism required for maintenance of proliferation of primitive HPCs and that unscheduled stimulation of CD34+ cells residing in G0 may result in disruption of cell-cycle regulation. [less ▲]

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See detailEstimation d'un indice de la valeur récréative des forêts
Lejeune, Philippe ULg; Rondeux, Jacques ULg; Verstraete, Philippe

in Mitteilungen der Abteilung für Forstliche Biometrie (1997), 97(2), 20-30

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See detailA primal-dual approach in truss topology optimization
Beekers, M.; Fleury, Claude ULg

in Computers & Structures (1997), 64(1-4), 77-88

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are ... [more ▼]

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are bounds on bar volumes and the satisfaction of equilibrium equations. For a single load case and without bounds on bar volumes, the problem can be written as a linear programming problem with nodal displacements as variables. The addition to the objective function of a quadratic term vanishing at the optimum allows us to use a dual solution scheme. A conjugate gradient method is well suited to maximize the dual function. Several ground structures are introduced. For large networks, those where each node is connected to those situated in a certain vicinity give a good compromise between generating a reasonable number of bars and obtaining a sufficient number of possible directions. Some examples taken from the literature are treated to illustrate the quality of the solution and the influence of initial topology. (C) 1997 Civil-Comp Ltd and Elsevier Science Ltd. [less ▲]

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See detailLong term follow-up of patients with acute myelogenous leukemia who received the daunorubicin, vincristine, and cytosine arabinoside regimen.
Beguin, Yves ULg; Sautois, Brieuc ULg; Forget, Patricia ULg et al

in Cancer (1997), 79(7), 1351-4

BACKGROUND: In 1985, the authors published a study of acute myelogenous leukemia (AML) patients treated with a chemotherapeutic regimen that was then considered intensive. Ten years later, the authors ... [more ▼]

BACKGROUND: In 1985, the authors published a study of acute myelogenous leukemia (AML) patients treated with a chemotherapeutic regimen that was then considered intensive. Ten years later, the authors reanalyzed the same cohort to determine whether the very promising actuarial results observed at 5 years held after longer follow-up. METHODS: Between 1977 and 1982, 61 patients with AML were treated with a protocol consisting of daunorubicin, vincristine, and cytosine arabinoside induction followed by consolidation and maintenance for a total of 2 years. The complete remission (CR) rate was 66%, 84% in males versus 47% in females (P < 0.005). At the time of the first analysis in 1984, the overall survival (OS) was 17%, the projected 5-year continuous CR rate (CCR) 32%, and the disease free survival (DFS) rate 29%, with the best results observed for males and for patients ages 40-60 years (P < 0.05). RESULTS: When the data were reanalyzed 11 years later in 1995, the results were 14% OS, 23% CCR, and 16% DFS at 5 years. However, these figures dropped to 8%, 18%, and 11% at 10 years and to 8%, 12%, and 7% at 15 years, respectively. Among the 40 CR patients, 31 relapsed (up to 13 years after CR), and all died within 1.6 years after relapse. Nine patients were in CCR: 4 died of unrelated causes (suicide, alcoholic cirrhosis, acute peritonitis, or bladder carcinoma), 1 was lost to follow-up after 11 years, 2 were alive and well at 17 years at last follow-up, and 2 were transplanted in first CR and were doing well at 13 and 14 years at last follow-up. The survival advantage for males over females persisted (P = 0.0197), but the advantage for patients age 40-60 years did not hold. CONCLUSIONS: These long term data indicate that actuarial analysis at 5 years may overestimate the cure rate of AML patients because a number of late relapses do occur. However, the picture is blurred by the incidence of death not related to leukemia or its treatment; and when these patients were censored at the time of death, 17% of CR patients were still projected to be alive and free of leukemia after 17 years. [less ▲]

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See detailGREES recommendations for the Registration of new drugs in the prevention and treatment of osteoporosis
Reginster, Jean-Yves ULg; Compston, J

in Calcified Tissue International (1997), 60

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See detailProgesterone receptors (PR) in ectopic endometrium?
NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (1997), 68(5), 943-4

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See detailMolecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Biochemical and Biophysical Research Communications (1997), 237

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding ... [more ▼]

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding proteins are displayed on mature sperm cells. In each mammalian species, a restricted subset of olfactory receptors is expressed in male germ cells and displays a pattern of expression suggestive of their potential implication in the control of sperm physiology. In addition to the cDNA fragments available previously, we now report the molecular cloning of two olfactory receptor cDNAs from a human testis library. Five olfactory receptor genes expressed in germ cells were localized in the human genome by radiation hybrid mapping. Three of the genes map to the short arm of chromosome 19 (19p13.1-19p31.3), one to chromosome 11 (11q22.1-22.3), and one to chromosome 17 (17q21-22). The former two localizations fall within clusters previously identified for members of the putative olfactory receptor gene family expressed in olfactory mucosa. Similarly, sequence analysis has revealed that these testicular genes share no distinctive structural features from the other, non-testicular, members of the family. The expression of a subset of olfactory receptor genes in the male germ line is therefore not correlated to their belonging to a specific structural subgroup, or to a specific gene cluster or chromosomal segment [less ▲]

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See detailmorbidity in neonates afetr labour induction or cesarean section
Battisti, Oreste ULg; Bertrand, J. M.; Adant-François, A. et al

in vlaamse verenigong voor obstetrie en gynaecologie jaarboek (1997), 1

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See detailPrimary radiation therapy or surgery combined or not to radiation therapy in the management of squamous cell carcinoma of the penis
Zouhair, Abderrahim; Ozsahin, Mahmut; Douglas, Pelham et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 39(2 (Supplément)), 295

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See detailDrug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments.
Scheen, André ULg

in Drugs (1997), 54(3), 355-68

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various ... [more ▼]

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various pharmacological approaches to improving glucose homeostasis, but those currently used in clinical practice either do not succeed in restoring normoglycaemia in most patients or fail after a variable period of time. For glycaemic regulation, 4 classes of drugs are currently available: sulphonylureas, biguanides (metformin), alpha-glucosidase inhibitors (acarbose) and insulin, each of which has a different mode and site of action. These standard pharmacological treatments may be used individually for certain types of patients, or may be combined in a stepwise fashion to provide more ideal glycaemic control for most patients. Adjunct treatments comprise a few pharmacological approaches which may help to improve glycaemic control by correcting some abnormalities frequently associated with NIDDM, such as obesity (serotoninergic anorectic agents) and hyperlipidaemia (benfluorex). There is intensive pharmaceutical research to find new drugs able to stimulate insulin secretion (new sulphonylurea or nonsulphonylurea derivatives, glucagon-like peptide-1), improve insulin action (thiazolidinediones, lipid interfering agents, glucagon antagonists, vanadium compounds) or reduce carbohydrate absorption (miglitol, amylin analogues, glucagon-like peptide-1). Further studies should demonstrate the superiority of these new compounds over the standard antidiabetic agents as well as their optimal mode of administration, alone or in combination with currently available drugs. [less ▲]

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See detailEtude histologique de lésions subcliniques de la lèvre latérale du talus chez le cheval
Yousfi, S.; Gabriel, Annick ULg; Maroit, V. et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailThe Cloning And Sequencing Of An Ovine C-Myc Cdna
Kiermer, V.; Dequiedt, Franck ULg; Masengo, R. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1997), 7(3-4),

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See detailBankfull discharge recurrence interval in gravel bed rivers
Petit, François ULg; Pauquet, A.

in Earth Surface Processes & Landforms (1997)

Bankfull discharge was identified in some 30 gravel-bed rivers representing in total c. 40 gauging stations. The catchment sizes vary from 4km2 to nearly 2700km2. Bankfull discharge values increases with ... [more ▼]

Bankfull discharge was identified in some 30 gravel-bed rivers representing in total c. 40 gauging stations. The catchment sizes vary from 4km2 to nearly 2700km2. Bankfull discharge values increases with basin size. In the case of gravel-bed rivers developed on an impermeable substratum, the following equation emerges: Qb=0·087 A1·044. Bankfull discharge recurrence interval was determined by fitting maximum annual floods (Ta) into Gumbel’s distribution and then using the partial duration series (Tp) in this same distribution. Recurrence interval is below 0·7 years (Tp) for small pebble-bed rivers developed on an impermeable substratum; it reaches 1·1 to 1·5 years when the catchment size of these rivers exceeds 250km2. Rivers incised in the soft schists of the Famenne show larger channel capacity at bankfull stage, a small width/depth ratio and thus higher recurrence intervals (1·4–5·3 years with Ta and 1–4·4 years with Tp). Baseflow-dominated gravel-bed streams and sandy or silty rivers experience less frequent bankfull discharges, with a recurrence interval higher than 2 or even 3 years (Tp). [less ▲]

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See detailRoles of circadian rhythmicity and sleep in human glucose regulation.
Van Cauter, E.; Polonsky, K. S.; Scheen, André ULg

in Endocrine Reviews (1997), 18(5), 716-38

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See detailOptimizing the treatment of Paget’s disease of bone
Reginster, Jean-Yves ULg; Gennari, C; Hosking, DJ et al

in Revue du Rhumatisme (English ed.) (1997), 64(4), 207-209

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See detailEmerging Roles for Proteinases in Cancer
Noël, Agnès ULg; Gilles, Christine ULg; Bajou, Khalid ULg et al

in Invasion & Metastasis (1997), 17(5), 221-39

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these ... [more ▼]

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these processes was initially thought to be the destruction of extracellular matrices. However, recent evidence suggests that they mainly affect tumor growth rather than invasion. Proteinases can indeed generate active matrix protein fragments, influence the release, the activation and the bioavailability of growth factors, and consequently modulate tumor cell growth, apoptosis and angiogenesis. Additionally, proteinases, their receptors and/or inhibitors can be directly involved in cell migration and in the processing or shedding of cell surface proteins. Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies. [less ▲]

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See detailGenetic markers may predict disease behavior in patients with ulcerative colitis.
Roussomoustakaki, M.; Satsangi, J.; Welsh, K. et al

in Gastroenterology (1997), 112(6), 1845-53

BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The ... [more ▼]

BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The aim of this study was to test these hypotheses in patients undergoing surgery for their colitis. METHODS: HLA DRB1 and DQB1 genotyping was performed in 99 patients and 472 controls. Genotyping for polymorphisms of genes encoding tumor necrosis factor alpha and IL-1RA was performed in 107 patients and 89 controls. Measurement of antineutrophil cytoplasmic antibody (ANCA) was performed in 72 patients and 58 healthy subjects by fixed neutrophil enzyme-linked immunosorbent assay and indirect immunofluorescence. RESULTS: The DRB1*0103 allele was increased in patients (14.1% vs. 3.2% in controls; P < 1 x 10[-5]). This association was greatest in patients with extensive disease (15.8%; P < 0.0001) or extraintestinal manifestations (22.8%; P < 0.0001): mouth ulcers (25.8%; P < 0.0001), arthritis (27.2%; P < 0.0001), and uveitis (35.7%; P < 0.0001). The DRB1*04 alleles were reduced in patients (P = 0.005). Differences were noted between extensive and distal disease in the frequency of allele 2 of IL-1RA (10.9% in distal vs. 28.6% in extensive; P = 0.01) and allele 2 homozygosity. ANCA was detected in 76.4% of patients. Carriage of IL-1RA allele 2 and tumor necrosis factor 2 allele was increased in ANCA-positive patients. CONCLUSIONS: Genetic markers may predict disease behavior in ulcerative colitis. [less ▲]

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See detailAnisotropie de la suceptibilité magnétique dans une intrusion composite de la suite charnockitique: l'apophyse du massif stratiforme de Bjerkreim-Sokndal (Rogaland, Norvège méridionale)
Bolle, Olivier ULg; Diot, Hervé; Duchesne, Jean-Clair ULg

in Comptes Rendus de l'Académie des Sciences. Série II, Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (1997), 325

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See detailFatty acid hydroperoxides pathway in plants. A review
Fauconnier, Marie-Laure ULg; Marlier, M.

in Grasas y Aceites (1997), 48(1), 30-37

The present paper focusses on the fatty acid hydroperoxides pathways, mainly hydroperoxide lyase and hydroperoxide dehydrase. For each enzyme, the definition, occurrence and subcellular localization is ... [more ▼]

The present paper focusses on the fatty acid hydroperoxides pathways, mainly hydroperoxide lyase and hydroperoxide dehydrase. For each enzyme, the definition, occurrence and subcellular localization is presented. Particular attention is given to reaction mecanisms and to substrate specificity. Physiological roles of reaction products are also discussed. [less ▲]

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See detailEnantioseparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using mixtures of anionic and uncharged beta-cyclodextrins as chiral additives.
Fillet, Marianne ULg; Hubert, Philippe ULg; Crommen, Jacques ULg

in Electrophoresis (1997), 18(6), 1013-8

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta ... [more ▼]

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta-cyclodextrin) in combination with a neutral cyclodextrin as chiral additives to a pH 3 phosphoric acid-triethanolamine buffer. In the presence of a negatively charged cyclodextrin, the analytes were given an appropriate mobility but relatively low enantioselectivities were generally obtained when such a cyclodextrin was the only selector added to the buffer. The addition of an uncharged cyclodextrin, such as the native beta-cyclodextrin or one of its derivatives (dimethyl-, trimethyl- and hydroxypropyl-beta-cyclodextrin), to this kind of buffer containing an anionic cyclodextrin, was found to give rise to considerable improvement in chiral resolution for all compounds studied. Resolution and analysis time were optimized by varying the nature and concentration of the two cyclodextrins. The best compromise was usually achieved by the simultaneous addition of sulfobutyl ether beta-cyclodextrin and trimethyl-beta-cyclodextrin. Under optimum conditions, the enantiomers of all NSAIDs examined could be completely separated (most often with resolution values higher than 5) in short analysis times (generally lower than 15 min). [less ▲]

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See detailLe bois de tension. 1 Définition et distribution dans l'arbre.
Jourez, Benoît ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(2), 100-112

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See detailFibres alimentaires chez le chien IV. Effets sur les ingestions, le poids, les matières fécales et sur la digestibilité des nutriments
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The present paper summarizes the influence of diets enriched with fibres on voluntary feed intakes, bodyweight changes of dogs and feces. Fibres affect nutrients digestibility by different mechanisms. The ... [more ▼]

The present paper summarizes the influence of diets enriched with fibres on voluntary feed intakes, bodyweight changes of dogs and feces. Fibres affect nutrients digestibility by different mechanisms. The induced changes vary according to the types of fibre-soluble, insoluble or both- and are, on the whole, quite similar with dogs as in other monogastric species. [less ▲]

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See detailPalynological evaluation of the Famennian Protosalvinia (Foerstia) Zone in the Amazon basin, Northern Brazil : a preliminary study.
Loboziak; Melo, J.H.G.; Quadros, L.P. et al

in Review of Palaeobotany and Palynology (1997), 96

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See detailLes comportements des enseignants dans la perspective d'un traitement différencié des élèves
Piéron, Maurice; Ledent, Maryse; Pirottin, Véronique et al

in Revue de l'Education Physique (1997), 4

La pédagogie basée sur la théorie des "rythmes d'apprentissage" accorde une place privilégiée à l'individualisation et contredit le principe d'une programmation uniforme, valable pour tous. Toute classe ... [more ▼]

La pédagogie basée sur la théorie des "rythmes d'apprentissage" accorde une place privilégiée à l'individualisation et contredit le principe d'une programmation uniforme, valable pour tous. Toute classe est hétérogène, chaque enfant étant singulier, différent dans ses valeurs, ses attitudes, ses potentialités et ses compétences. Chacun apprend à un rythme différent, plus rapidement que la moyenne dans des domaines, moins rapidement dans d'autres. ... [less ▲]

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See detailInformation transfer between angiographic films and CT images: a tool to delineate the target volume
Tercier, P-A; COUCKE, Philippe ULg; Fankhauser, H et al

in Radiotherapy & Oncology (1997), 45

Abstract Background and purpose: This work was undertaken to improve the definition of target volumes for radiosurgery using the angiographic and CT data. Materials and methods: The basis of this new ... [more ▼]

Abstract Background and purpose: This work was undertaken to improve the definition of target volumes for radiosurgery using the angiographic and CT data. Materials and methods: The basis of this new method is to combine both imaging modalities and to compare them in each representation, i.e. to plot the volume obtained by angiography on CT images and also the contours defined by the CT on angiographic films. To obtain the angiographic volume, the radiographs are taken at several incidence angles. The X-ray sources position and the position of the films are determined using rectangular markers, then the intersection of all the loci of the target volume are calculated. Results: Verifications with a phantom show the accuracy of the procedure and the benefit obtained by increasing the number of angles of incidence in the angiographic imaging. The centre of gravity of the experimental target could be localized to an accuracy of better than 0.4 mm. The method was used in 11 clinical cases with excellent clinical results. Conclusions: The method can be easily applied and improves the delineation of target volumes in radiosurgery. CT data counterbalances the relative weakness of angiography concerning the three-dimensional geometry. Angiography adds useful information on the blood flow that is not shown in CT. Almost all the presented clinical cases benefit from the technique described here. [less ▲]

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See detailComparison of radiography , magnetic resonance imaging and surgical findings in dogs with elbow dysplasia
Snaps, Frédéric ULg; Balligand, Marc ULg; Saunders, J. et al

in American Journal of Veterinary Research (1997), 58(12), 1367-1370

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for ... [more ▼]

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for evaluation of fragmented medial coronoid process (FMCP) and lesions of the medial aspect of the humeral condyle (MAHC). Animals-18 dogs with elbow dysplasia. Procedure-Radiography of 22 cubital joints was performed. The 22 joints then underwent MRI. The scans were evaluated with regard to the shape and signal of the coronoid process; articular cartilage change, subchondral bone disruption of the MAHC. Surgical findings were used as the standard to calculate accuracy, sensitivity, specificity, and positive-and negative-predictive values for specific diagnosis of FMCP (free fragment) and lesions of the MAHC. Results-At surgery, 31.8% of the joints had FMCP (free), 36.4% had nondisplaced unmineralized coronoid process, and 27.2% had nondisplaced mineralized coronoid process, Eleven joints had lesions of the MAHC, and wear lesions were observed in 41% of the joints. On radiography, FMCP (free) was visualized in 9% of the joints and lesions of the MAHC were observed in 23%. MRI had the highest accuracy (95.5%), sensitivity (100%), and negative-predictive value (100%) for detection of FMCP (free), and had accuracy (91%), sensitivity (87.5%), specificity (92.5%), and positive (87.5%)- and negative (92.5%)- predictive values for detection of nondisplaced unmineralized coronoid process. Conclusions and Clinical relevance-Compared with radiography, MRI was useful for detection of nondisplaced unmineralized coronoid process; images consistently correlated with surgical findings. The technique is accurate and especially useful when radiographic findings are inconclusive. [less ▲]

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See detailPrevention and treatment of postmenopausal osteoporosis. National consensus of the Belgian Bone Club"
Kaufman, JM; Devogelaer, JP; Raeman, F et al

in Clinical Rheumatology (1997), 16(4), 343-345

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See detailLes moyens de se prémunir contre la défaillance de ses cocontractants
Georges, Frédéric ULg

in Actualités du Droit (1997)

Cette contribution commentait l'impact de la réforme de 1997 du droit de l'insolvabilité sur les droits des créanciers

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See detailFunctional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle.
GOTHOT, André ULg; Pyatt, R.; McMahel, J. et al

in Blood (1997), 90(11), 4384-93

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the ... [more ▼]

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the cell cycle by flow cytometric cell sorting. In both bone marrow (BM) and mobilized peripheral blood (MPB) CD34(+) cells, primitive long-term hematopoietic culture-initiating cell (LTHC-IC) activity was higher in CD34(+) cells isolated in G0 (G0CD34(+) cells) than in those residing in G1 (G1CD34(+) cells). However, as MPB CD34(+) cells displayed a more homogeneous cell-cycle status within the G0 /G1 phase and a relative absence of cells in late G1 , DNA/RNA fractionation was less effective in segregating LTHC-IC in MPB than in BM. BM CD34(+) cells belonging to four subcompartments of increasing RNA content within the G0 /G1 phase were evaluated in functional assays. The persistence of CD34 expression in suspension culture was inversely correlated with the initial RNA content of test cells. Multipotential progenitors were present in G0 or early G1 subcompartments, while lineage-restricted granulomonocytic progenitors were more abundant in late G1 . In vitro hematopoiesis was maintained for up to 6 weeks with G0CD34(+) cells, whereas production of clonogenic progenitors was more limited in cultures initiated with G1CD34(+) cells. To test the hypothesis that primitive LTHC-ICs would reenter a state of relative quiescence after in vitro division, BM CD34(+) cells proliferating in ex vivo cultures were identified from their quiescent counterparts by a relative loss of membrane intercalating dye PKH2, and were further fractionated with Hst and PY. The same functional hierarchy was documented within the PKH2(dim) population whereby LTHC-IC frequency was higher for CD34(+) cells reselected in G0 after in vitro division than for CD34(+) cells reisolated in G1 or in S/G2 + M. However, the highest LTHC-IC frequency was found in quiescent PKH2(bright) CD34(+) cells. Together, these results support the concept that cells with distinct hematopoietic capabilities follow different pathways during the G0 /G1 phase of the cell cycle both in vivo and during ex vivo culture. [less ▲]

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See detailComparison between different methods of measurement of momentum and sensible heat fluxes over canopies.
Aubinet, Marc ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(1),

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See detailEvaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways
Duvivier, Dominique Hannia; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Veterinary Research (1997), 28(6), 557-564

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M ... [more ▼]

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M). The in vitro inhalation study was performed using the cascade impaction method (Andersen Sampler) adapted to imitate nasal breathing. The amount of ipratropium found in the device, the artificial upper airways and the six stages of the Andersen Sampler was measured using high precision liquid chromatography. Stage 1 of the Andersen Sampler was considered to be the respirable fraction and stages 2 to 6 to be the non-respirable fraction. It was concluded that the theoretical respirable fraction of ipratropium obtained after DPI through Inhalator M was influenced by relative air humidity, air flow and the position of the device, whereas the number of successive inspirations and the duration of inspiration did not affect this fraction of the drug. [less ▲]

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See detailProduction and activation of matrix metalloprotease-9 (MMP-9) by HL-60 promyelocytic leukemia cells
Devy, L.; Noël, Agnès ULg; Baramova, E. et al

in Biochemical and Biophysical Research Communications (1997), 238

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of ... [more ▼]

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of extracellular matrix components. As shown by gelatin zymography, HL-60 cells constitutively released significant amounts of proMMP-9 (92 kDa) and moderate amounts of proMMP-2 (72 kDa). Furthermore, casein zymography confirmed the presence of serine proteases in the form of pro-urokinase. Activation of proMMP-9 was dependent on the plasminogen activator/plasmin (PA/plasmin) system and was inhibited by aprotinin. MMP-9 was only detected in cellular extracts or conditioned media incubated with HL-60 cells, indicating that cells are essential to the activation process. Addition of plasminogen increased by 3-fold the basal invasive rate of these cells across a matrigel layer (2.1%versus0.7% in control cells after 4 h of incubation). Taken together, these results indicate that HL-60 cells exhibit an autocrine activation mechanism of proMMP-9 via the PA/plasmin system and that activation of proMMP-9 increases their invasive potential [less ▲]

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See detailComparison of results of carotid artery surgery after either direct closure or use of a vein patch.
Desiron, Quentin ULg; Detry, Olivier ULg; Van Damme, Hendrik ULg et al

in Cardiovascular Surgery (1997), 5(3), 295-303

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting ... [more ▼]

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting of saphenous vein bypass (n = 29) and eversion endarterectomy (n = 85), 2157 open endarterectomies were performed. They were closed either directly (n = 837) or using a vein patch (n = 1320). The combined mortality-major neurological morbidity rate was 1.7%, i.e. 1% mortality (0.2% neurological) and 0.7% permanent neurological morbidity (0.5% ipsilateral to the operated artery). Early symptomatic internal carotid thrombosis was documented in six cases (four following direct closure and two after vein patching). A total of 827 carotid arteries were followed up by duplex scanning on an annual basis (244 direct closure and 583 vein patching). The mean follow-up was 44 months; 69 months for direct closure and 35 months for vein patching. In direct closure, there were 21 stenoses (9%) and 10 occult thromboses (4%); in vein patching carotids, there were 17 stenoses (3%), nine thromboses (1.8%) [corrected] and six pseudoaneurysms (1%). Annual incidence of poor results was 2.4% in direct closure, and 0.87% in vein patching. The only other factor responsible for a significant difference was gender (3.4% in women versus 2.1% in men). In this retrospective study, vein patching appears to be beneficial for the prevention of acute postoperative thrombosis and late stenosis or thrombosis. [less ▲]

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See detailVincenzo Giordano Zocchi, Memorie di un ebete, a cura di M. C. Cafisse, Napoli, Federico & Ardia, 1995, LVI-239
Curreri, Luciano ULg

in Giornale Storico della Letteratura Italiana (1997), CLXXIV/568

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