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See detailLes protéases stromales dans la progression cancéreuse mammaire
Foidart, Jean-Michel ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1997), 152(5), 229-35235-7

Matrix metalloproteases represent a family of proteases secreted as latent inactive enzymes able to degrade the majority of extracellular matrix components. These enzymes are overexpressed during several ... [more ▼]

Matrix metalloproteases represent a family of proteases secreted as latent inactive enzymes able to degrade the majority of extracellular matrix components. These enzymes are overexpressed during several pathological tissue remodelings including tumor progression and tumor invasion. It was indeed classically admitted that matrix metalloproteases involved in tumoral progression were preferentially expressed by cancerous cells. Our studies on gelatinase A and stromelysin-3 have, however, demonstrated that their messenger RNAS are detected in fibroblasts of the peritumoral stroma in human mammary carcinoma and not in the cancerous cells themselves. By immunohistochemistry, we have detected gelatinase A in the cytoplasm of fibroblasts and at the surface of the tumor cells. This membrane localization of the protein could result from its binding, following secretion by the neighbouring stromal cells, to a specific binding site expressed at the surface of the carcinoma cells. These cells are indeed able to induce an increased proteolytic activity by enhancing the transcription of these enzymes by peritumoral fibroblasts. These enzymes represent therefore potential targets for the development of new therapeutic strategies. [less ▲]

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See detailLe Système d'informations sur la Biodiversité en Wallonie.
Dufrêne, Marc ULg

in Les cahiers des Réserves Naturelles RNOB (1997), 11

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See detailRadiation therapy duration influences overall survival in patients with cervix carcinoma.
Coucke, Philippe ULg; Delaloye, J-F; Pampallona, S et al

in International Journal of Gynecology & Obstetrics (1997), 57

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation ... [more ▼]

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to the duration of the therapies, taking 60 days (the 75th percentile) as an arbitrary cut-off. Results: The 5-year survival was 61% (SE. = 3%) for the therapy duration group of less than 60 days and 53% (SE. = 7%) for the group of more than 60 days. In terms of univariate hazard ratio (HR), the relative difference between the hvo groups corresponds to a 50% increase of deaths (HR = 1.53, 95% CI = 1.03-2.28) for the longer therapy duration group (P = 0.044). In a multivariate analysis, the magnitude of estimated relative hazards for the longer therapies are confirmed though significance was reduced (HR = 1.52, 95% CI = 0.94-2.45, P = 0.084). Conclusion: These findings suggesthat short treatment duration is a factor associated with longer survival in carcinoma of the cervix. 0 1997 International Federation of Gynecology and Obstetrics [less ▲]

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See detailComparison of radiography , magnetic resonance imaging and surgical findings in dogs with elbow dysplasia
Snaps, Frédéric ULg; Balligand, Marc ULg; Saunders, J. et al

in American Journal of Veterinary Research (1997), 58(12), 1367-1370

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for ... [more ▼]

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for evaluation of fragmented medial coronoid process (FMCP) and lesions of the medial aspect of the humeral condyle (MAHC). Animals-18 dogs with elbow dysplasia. Procedure-Radiography of 22 cubital joints was performed. The 22 joints then underwent MRI. The scans were evaluated with regard to the shape and signal of the coronoid process; articular cartilage change, subchondral bone disruption of the MAHC. Surgical findings were used as the standard to calculate accuracy, sensitivity, specificity, and positive-and negative-predictive values for specific diagnosis of FMCP (free fragment) and lesions of the MAHC. Results-At surgery, 31.8% of the joints had FMCP (free), 36.4% had nondisplaced unmineralized coronoid process, and 27.2% had nondisplaced mineralized coronoid process, Eleven joints had lesions of the MAHC, and wear lesions were observed in 41% of the joints. On radiography, FMCP (free) was visualized in 9% of the joints and lesions of the MAHC were observed in 23%. MRI had the highest accuracy (95.5%), sensitivity (100%), and negative-predictive value (100%) for detection of FMCP (free), and had accuracy (91%), sensitivity (87.5%), specificity (92.5%), and positive (87.5%)- and negative (92.5%)- predictive values for detection of nondisplaced unmineralized coronoid process. Conclusions and Clinical relevance-Compared with radiography, MRI was useful for detection of nondisplaced unmineralized coronoid process; images consistently correlated with surgical findings. The technique is accurate and especially useful when radiographic findings are inconclusive. [less ▲]

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See detailThe Penicillin sensory transducer, blar, involved in the inducibility of beta-lactamase synthesis in bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle
Hardt, Karin; Joris, Bernard ULg; Lepage, Sophie et al

in Molecular Microbiology (1997), 23(5), 935-944

Prediction studies, conformational analyses and membrane-topology mapping lead to the conclusion that the penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in ... [more ▼]

Prediction studies, conformational analyses and membrane-topology mapping lead to the conclusion that the penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in Bacillus licheniformis, is embedded in the plasma membrane bilayer via four transmembrane segments TM1-TM4 that forma four-alpha-helix bundle. The extracellular 262-amino-acid-residue polypeptide, S340-R601, that is fused at the carboxy end of TM4, possesses the amino acid sequence signature of a penicilloyl serine transferase. It probably functions as penicillin sensor. As an independent entity, this polypeptide behaves as a high-affinity penicillin-binding protein. As a component of the full-size BlaR, it adopts a different conformation presumably because of interactions with the extracellular 63-amino-acid-residue P53-S115 loop that connects TM2 and TM3. Reception of the penicillin-induced signal requires a precise conformation of the sensor but it does not involve penicilloylation of the serine residue S402 of motif STYK. Signal transmission through the plasma membrane by the four-alpha-helix bundle may proceed in a way comparable to that of the aspartate receptor, Tar. Signal emission in the cytosol by the intracellular 189-amino-acid-residue Y134-K322 loop that connects TM3 and TM4, may proceed via the activation of a putative metallopeptidase. [less ▲]

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See detailLes armées d'Alexandre le Grand et les langues étrangères
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1997), 66

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See detailFibres alimentaires chez le chien IV. Effets sur les ingestions, le poids, les matières fécales et sur la digestibilité des nutriments
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The present paper summarizes the influence of diets enriched with fibres on voluntary feed intakes, bodyweight changes of dogs and feces. Fibres affect nutrients digestibility by different mechanisms. The ... [more ▼]

The present paper summarizes the influence of diets enriched with fibres on voluntary feed intakes, bodyweight changes of dogs and feces. Fibres affect nutrients digestibility by different mechanisms. The induced changes vary according to the types of fibre-soluble, insoluble or both- and are, on the whole, quite similar with dogs as in other monogastric species. [less ▲]

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See detailPeritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities
NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (1997), 68(4), 585-596

Objective: To review the histogenesis of peritoneal, ovarian, and rectovaginal endometriotic lesions. Design: The comparison of morphologic, morphometric, and histochemical data observed in each type of ... [more ▼]

Objective: To review the histogenesis of peritoneal, ovarian, and rectovaginal endometriotic lesions. Design: The comparison of morphologic, morphometric, and histochemical data observed in each type of lesion. Setting: A university hospital department of gynecology. Patient(s): Patients complaining of infertility or pelvic pain with laparoscopically proved endometriosis. Intervention(s): Laparoscopy was performed, and biopsy specimens from the endometriotic lesions were histologically studied. Result(s): Three types of endometriotic lesions must be considered: peritoneal, ovarian, and rectovaginal. Morphologic and morphometric data show similarities between eutopic endometrium and red peritoneal lesions, suggesting that these lesions are the first stage of early implantation of endometrial glands and stroma. After partial shedding, the red lesions regrow constantly. The shedding induces an inflammatory reaction, provoking scarification, and the lesions become black. The subsequent fibrosis leads to areas of white opacification that are inactive. The pathogenesis of ovarian endometriomas is a source of controversy. Although there seems to be a consensus concerning the invagination theory, there is still a contradiction between the implantation theory and the metaplasia theory. We recently showed that the mesothelium covering the ovary can invaginate into the ovarian cortex, pushing back the primordial follicles. The presence of mesothelial invagination in continuum with endometriotic tissue suggests that metaplastic histogenesis of ovarian endometriotic lesions occurs. Rectovaginal endometriotic nodules must be considered adenomyomas, consisting of smooth muscle with active glandular epithelium and scanty stroma. Immunocytochemical results show poor differentiation and hormonal independence of these lesions and indicate a close relation with their mesodermal müllerian origin. Conclusion(s): Peritoneal, ovarian and rectovaginal endometriotic lesions must be considered as three separate entities with different pathogeneses. [less ▲]

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See detailWhole organ vascularized cluster heart-thymus allografting : Experiences with a novel experimental model
D'Silva, Milbhor; Antoniou, E.; Howie, A. J. et al

in Cardiovascular Engineering : An International Journal (1997), 2(1), 65-74

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See detail5-(Diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide : Synthesis and Evaluation of Spin Trapping Properties
Roubaud, Valérie; Mercier, Anne; Olive, Gilles ULg et al

in Journal of the Chemical Society. Perkin Transactions 2 (1997), 9

A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been ... [more ▼]

A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been investigated and the hydroxyl and superoxide spin adducts characterised. The persistence of the superoxide spin adduct obtained with 3 is compared with those of the analogues obtained with DEPMPO [5-(diethoxyphosphoryl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide] and DMPO in both phosphate buffer and pyridine. In 0.1 M phosphate buffer at pH 7.0, the HOO-3? adduct is found to be 2.8 times more persistent than HOO-DMPO?, but 5.7 times less than HOO-DEPMPO?. In phosphate buffer, HOO-3? decomposes to give HO-3?. The stereoselectivity of the addition of free radicals on 3 is generally poor, and mixtures of diastereomers have been observed by EPR. The overall spin trapping behaviour of nitrone 3 is more similar to that of DMPO than that of DEPMPO. [less ▲]

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See detailFibres alimentaires chez le chien V. Effets sur le métabolisme glucidique. Application dans le traitement du diabète
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

Some dietary fibres are characterized by hypoglycaemic and hypoinsulinemic effects in humans and in carnivores. At present, these properties are used in the treatment of diabetes mellitus in both species ... [more ▼]

Some dietary fibres are characterized by hypoglycaemic and hypoinsulinemic effects in humans and in carnivores. At present, these properties are used in the treatment of diabetes mellitus in both species. Finally, the dietary treatment of the diabetic dog is presented with a particular emphasis on the use of dietary fibres. [less ▲]

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See detailHistoires d'e
Dupont, Pascal ULg

in Math-Jeunes (1997), 80

Two definitions of the number $e$, $\displaystyle\lim_{n\rightarrow\infty}\left(1+\frac1n\right)^n$ and $\displaystyle\sum_{n=0}^\infty\frac1{n!}$, ares shown equivalent.

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See detailA role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm
Marine, Jean-Christophe; Bellefroid, Eric J.; Pendeville-Samain, Hélène ULg et al

in Mechanisms of Development (1997), 63(2), 211-25

Gli-type zinc finger proteins play important regulatory roles in vertebrate and invertebrate embryogenesis. In Xenopus, the Gli-type proteins XGli-3 and XGli-4 are first expressed in earliest stages of ... [more ▼]

Gli-type zinc finger proteins play important regulatory roles in vertebrate and invertebrate embryogenesis. In Xenopus, the Gli-type proteins XGli-3 and XGli-4 are first expressed in earliest stages of mesoderm and neural development. Transient transfection assays reveal that XGli-3 and XGli-4 can function as transcription repressors. Counteracting the Gli-protein repressor activity by ectopic expression of a fusion protein that contains the Gli-zinc finger cluster connected to the E1A activator domain in Xenopus embryos results in specific morphological alterations in the developing somites and in the central nervous system. Altered expression characteristics for a broad set of molecular markers highlighting specific aspects of mesodermal and neural differentiation demonstrate an important role for Gli-type zinc finger proteins in the early mesodermal and neural patterning of Xenopus embryos. [less ▲]

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See detailFibres alimentaires chez le chien VI. Effets sur le métabolisme lipidique, les sécrétions biliaires et application dans le traitement de l'obésité
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141(5), 363-372

Dietary fibres are able to affect lipids profiles in humans. The soluble and partly soluble fibres have mainly been studied in this purpose. Although hyperlipidaemia are known in dogs, there are few ... [more ▼]

Dietary fibres are able to affect lipids profiles in humans. The soluble and partly soluble fibres have mainly been studied in this purpose. Although hyperlipidaemia are known in dogs, there are few studies on the subject. The mechanisms by which fibres are involved are discussed with a particular emphasis on bile secretion. [less ▲]

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See detailLa responsabilité pénale du réviseur d'entreprises : Épée de Damoclès ou Tigre de papier ?
Thirion, Nicolas ULg; Benoit-Moury, Anne

in Revue pratique des sociétés (1997), (2), 189-229

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See detailPlasma pregnancy-associated glycoprotein and progesterone concentrations in pregnant Assaff ewes carrying single and twin lambs
Ranilla, Marie-José; Sulon, Joseph ULg; Mantecón, A. R. et al

in Small Ruminant Research (1997), 24(2), 125-131

Ovine pregnancy-associated glycoprotein (oPAG) and progesterone (P4) concentrations were monitored weekly during the last three months of gestation and the first month postpartum in plasma of twelve Assaf ... [more ▼]

Ovine pregnancy-associated glycoprotein (oPAG) and progesterone (P4) concentrations were monitored weekly during the last three months of gestation and the first month postpartum in plasma of twelve Assaf ewes. The oPAG levels were determined with a heterologous RIA using bovine PAG as standard and tracer and rabbit antiserum against oPAG. The P4 levels were measured with a radioimmunological procedure with a sensitivity to less than 0.1 ng/ml. The oPAG profiles in ewes carrying a single lamb and in those carrying twins were very similar from week 9 of gestation to lambing. Ewes which had twins presented numerically higher oPAG concentrations from week 12 to lambing, but that difference was only significant (p<0.05) at week 21. Ewes carrying twins presented higher (P<0.05) P4 concentrations from weeks 12 to 20 of gestation than those carrying a single lamb, but afterwards there was no difference. No correlation was found between P4 and oPAG concentrations at each stage of gestation studied in any group. After lambing, P4 levels dropped rapidly in one week, whereas oPAG decreased in four weeks to basal values in both groups of ewes. No relationship (P>0.05) was found between oPAG concentrations and lamb birth-weight at any week of gestation considered in this study. However, the lamb birth-weight was positively correlated (P<0.10) with the P4 concentrations from weeks 9 to 19 of gestation. Results indicate that number of fetuses could influence the oPAG production in ewes during the last three months of gestation. [less ▲]

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See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailL’arsénopyrite du Massif de Stavelot, Belgique
Hatert, Frédéric ULg

in Bulletin de la Société Royale des Sciences de Liège (1997), 66

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See detailAn Easy Way to Increase the Finite-Sample Efficiency of the Resampled Minimum Volume Ellipsoid Estimator
Croux, Christophe ULg; Haesbroeck, Gentiane ULg

in Computational Statistics & Data Analysis (1997), 25

In a robust analysis, the minimum volume ellipsoid (MVE) estimator is very often used to estimate both multivariate location and scatter. The MVE estimator for the scatter matrix is defined as the ... [more ▼]

In a robust analysis, the minimum volume ellipsoid (MVE) estimator is very often used to estimate both multivariate location and scatter. The MVE estimator for the scatter matrix is defined as the smallest ellipsoid covering half of the observations, while the MVE location estimator is the midpoint of that ellipsoid. The MVE estimators can be computed by minimizing a certain criterion over a high-dimensional space. In practice, one mostly uses algorithms based on minimization of the objective function over a sequence of trial estimates. One of these estimators uses a resampling scheme, and yields the (p + 1)-subset estimator. In this note, we show how this estimator can easily be adapted, yielding a considerable increase of statistical efficiency at finite samples. This gain in precision is also observed when sampling from contaminated distributions, and it becomes larger when the dimension increases. Therefore, we do not need more computation time nor do we lose robustness properties. Moreover, only a few lines have to be added to existing computer programs. The key idea is to average over several trials close to the optimum, instead of just picking out the trial with the lowest value for the objective function. The resulting estimator keeps the equivariance and robustness properties of the original MVE estimator. This idea can also be applied to several other robust estimators, including least-trimmed-squares regression. [less ▲]

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See detailA new generation of hydrocolloid dressings in combination with topical corticosteroids in the treatment of psoriasis vulgaris
Dezfoulian, Bita ULg; de LA BRASSINNE, Michel ULg; Rosillon, D.

in Journal of the European Academy of Dermatology & Venereology (1997), 9

Aim : A clinical, randomized, parallel, multicenter study was undertaken to compare the efficacy and Ihe tolerability of two known steroid creams, betamethasone 17-valerate and clobetasol propionate ... [more ▼]

Aim : A clinical, randomized, parallel, multicenter study was undertaken to compare the efficacy and Ihe tolerability of two known steroid creams, betamethasone 17-valerate and clobetasol propionate, alone or left under a hydrocolloid dressing (Contreei'* Derma Cover), in the treatment of chronic plaques of psoriasis. Methods : A total of 70 patients with symmetrical localized psoriasis were divided randomly into two groups for the study. Each patient applied ihe corticosteroid preparation under Contreet° Derma Cover once a week on one plaque and the same topical corticosteroid alone h.i.d on the other plaque; the treatment lasted 3 weeks for betamethasone 17-valerate, and 2 weeks for clobetasol propionate. Results : The heahng rate reached 79% with the Contreet" combined treatment versus 15% (P < 0,0001) with the standard treatment for betamethasone 17-valeratc (group I) and Sb% versus 14*70 (P < 0. 0001) for clobetasol propionate (group It). The mean difference in healing rate was 65% {95% confidence interval (C.I), 46-84%) and 69% (95% CL, 50-87%) in groups I and II, respectively. Conclusion : The use of the new generation of hydrocolloid dressings in combination with steroid preparations can be considered as another therapeutic option for the treatment of chronic localized psoriatic lesions. Furthermore, with this method the amount of the topical corticosteroid used can be reduced. [less ▲]

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See detailMutations in the immunosuppressive peptide of bovine leukema virus affect fusion and infectivity in vivo
Gatot, Jean-Stéphane; Kettmann, Richard ULg; Callebaut-Mornon, Isabelle et al

in Virus Research (1997), 47(2-Special Issue), 103

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See detailAcute Functional Iron Deficiency in Obese Subjects During a Very-Low-Energy All-Protein Diet
Beguin, Yves ULg; Grek, Vincent; Weber, Georges ULg et al

in American Journal of Clinical Nutrition (1997), 66(1), 75-9

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 ... [more ▼]

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 g protein after a 1-wk period during which total daily energy intake was progressively reduced to 1.26 MJ. Serum iron fell sharply by approximately equal to 50% (P < 0.0001), and despite a small decrease in total-iron-binding capacity, transferrin saturation decreased from 30 +/- 11% to 18 +/- 5% (P < 0.0001). Serum ferritin did not change significantly but serum soluble transferrin receptor (sTfR), an indicator of iron deficiency, increased progressively from 4630 +/- 1110 to 6070 +/- 1390 micrograms/L (P < 0.0001). Changes in sTfR correlated inversely with prior changes in serum iron. Changes in iron metabolism did not translate into changes in erythropoiesis or red cell indexes, but the white blood cell count decreased from 7.3 +/- 1.6 to 6.2 +/- 1.9 x 10(9)/L (P < 0.002). There was no evidence of deficiency for the other trace elements and minerals tested. Daily supplementation with 200 mg Fe in 18 other subjects only partially corrected these observations despite some increase in iron stores. These results indicate that during a 2-wk VLED serum iron is significantly depressed, inducing functional tissue iron deficiency too short in duration to produce alterations in red blood cell indexes. These changes are not mediated by absolute iron deficiency, inflammation, or protein malnutrition but could be related to alterations in the iron storage and release behavior of the reticuloendothelial cell during energy deprivation alone. [less ▲]

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See detailAnaemia of lung cancer is due to impaired erythroid marrow response to erythropoietin stimulation as well as relative inadequacy of erythropoietin production.
Dowlati, A.; R'Zik, Samir ULg; Fillet, Georges ULg et al

in British Journal of Haematology (1997), 97(2), 297-9

Many studies have been done in order to elucidate the pathogenesis of the anaemia of chronic disorders accompanying cancer, with conflicting results. This is probably due to the heterogeneity of the ... [more ▼]

Many studies have been done in order to elucidate the pathogenesis of the anaemia of chronic disorders accompanying cancer, with conflicting results. This is probably due to the heterogeneity of the patient population selected for these studies (many patients treated by chemotherapy). To avoid this pitfall, in this study a very homogenous group of chemotherapy and radiotherapy-naive patients with lung cancer were selected. Serum erythropoietin and soluble transferrin receptor measurements suggested that the anaemia of non-treated lung cancer is mainly due to an impaired erythroid marrow response to erythropoietin stimulation. However, a relative inadequacy of erythropoietin production may also contribute. [less ▲]

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See detailFunctional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle.
GOTHOT, André ULg; Pyatt, R.; McMahel, J. et al

in Blood (1997), 90(11), 4384-93

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the ... [more ▼]

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the cell cycle by flow cytometric cell sorting. In both bone marrow (BM) and mobilized peripheral blood (MPB) CD34(+) cells, primitive long-term hematopoietic culture-initiating cell (LTHC-IC) activity was higher in CD34(+) cells isolated in G0 (G0CD34(+) cells) than in those residing in G1 (G1CD34(+) cells). However, as MPB CD34(+) cells displayed a more homogeneous cell-cycle status within the G0 /G1 phase and a relative absence of cells in late G1 , DNA/RNA fractionation was less effective in segregating LTHC-IC in MPB than in BM. BM CD34(+) cells belonging to four subcompartments of increasing RNA content within the G0 /G1 phase were evaluated in functional assays. The persistence of CD34 expression in suspension culture was inversely correlated with the initial RNA content of test cells. Multipotential progenitors were present in G0 or early G1 subcompartments, while lineage-restricted granulomonocytic progenitors were more abundant in late G1 . In vitro hematopoiesis was maintained for up to 6 weeks with G0CD34(+) cells, whereas production of clonogenic progenitors was more limited in cultures initiated with G1CD34(+) cells. To test the hypothesis that primitive LTHC-ICs would reenter a state of relative quiescence after in vitro division, BM CD34(+) cells proliferating in ex vivo cultures were identified from their quiescent counterparts by a relative loss of membrane intercalating dye PKH2, and were further fractionated with Hst and PY. The same functional hierarchy was documented within the PKH2(dim) population whereby LTHC-IC frequency was higher for CD34(+) cells reselected in G0 after in vitro division than for CD34(+) cells reisolated in G1 or in S/G2 + M. However, the highest LTHC-IC frequency was found in quiescent PKH2(bright) CD34(+) cells. Together, these results support the concept that cells with distinct hematopoietic capabilities follow different pathways during the G0 /G1 phase of the cell cycle both in vivo and during ex vivo culture. [less ▲]

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See detailExpérimentation médicale sur l'être humain. Propositions pour un cadre législatif.
Palermini, Patricia ULg; Delfosse, Marie-Luce

in Revue de Droit de la Santé = Tijdschrift voor Gezondheidsrecht (1997), (5), 333-344

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See detailA two-dimensional Navier-Stokes inverse solver for compressor and turbine blade design
Demeulenaere, A.; Léonard, Olivier ULg; Van den Braembussche, René

in Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy (1997), 211(4), 299-307

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on ... [more ▼]

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on the blade surface. The method solves the time-dependent Navier-Stokes equations in a numerical domain of which some boundaries (the blade walls) move during the transient part of the computation. The geometry modification algorithm is based on the transpiration principle: a normal velocity distribution is computed from the difference between the actual and prescribed pressure distributions, and is used to modify the blade shape. A time iteration is then performed on this new blade shape, taking into account the grid movement during the time stepping. A two-dimensional upwind finite-volume Navier-Stokes solver has been developed. The multiblock strategy allows for a selective concentration of the discretization points in the zones of higher gradients. Applications to turbine and compressor blade design illustrate the accuracy of the flow computation, the capabilities and efficiency of the inverse method. [less ▲]

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See detailUne maison médiévale à Dinant
Hoffsummer, Patrick ULg

in Annales de la Société Archéologique de Namur (1997), 71

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See detailHiggs boson search at photon collider for M(h) = 140-GeV - 190-GeV
Ginzburg, I. F.; Ivanov, Igor ULg

in Physics Letters B (1997), 408

A Higgs boson within the mass range $M_H=140-190$ GeV can be discovered at a photon collider in the reaction $\gamma\gamma\to WW$ (with real or virtual W) with the luminosity integral about 1 fb$^{-1 ... [more ▼]

A Higgs boson within the mass range $M_H=140-190$ GeV can be discovered at a photon collider in the reaction $\gamma\gamma\to WW$ (with real or virtual W) with the luminosity integral about 1 fb$^{-1}$. The reasonable resolution in the effective mass of the WW system is required. [less ▲]

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See detailA one-nucleotide difference in a cAMP and phorbol ester response element leads to differential regulation of the human chorionic somatomammotropin A and B gene transcription
Oury, Cécile ULg; Alsat, E.; Jacquemin, P. et al

in Journal of Molecular Endocrinology (1997), 18(2), 87-99

Human chorionic somatomammotropin (hCS) is encoded by two highly related genes, hCS-A and hCS-B, located in the hGH/hCS gene locus. Both genes are expressed in the syncytiotrophoblast layer of the ... [more ▼]

Human chorionic somatomammotropin (hCS) is encoded by two highly related genes, hCS-A and hCS-B, located in the hGH/hCS gene locus. Both genes are expressed in the syncytiotrophoblast layer of the placenta and hCS release from trophoblast cells is known to be increased by cAMP and phorbol esters. However, it remains unclear whether this regulation acts at the level of hCS gene expression or secretion and whether both genes are affected. We examined the effects of cAMP and phorbol 12-myristate 13-acetate (PMA) on the transcription of the hCS-A and hCS-B genes. Transient expression experiments revealed a 7 bp cAMP- and PMA-responsive element (CRElhCS-A) spanning nucleotides-1102 to -1096 upstream of the hCS-A gene. In contrast, the homologous sequence upstream of hCS-B (CRElhCS-B), differing from CRElhCS-A by a single substitution, shows little or no response to cAMP. In band-shift assays, the CRElhCS-A oligonucleotide was shown to bind two factors related to CREBP and AP-1, whereas CRElhCS-B only competes for one of these complexes. Finally, Southwestern analysis revealed that the CRElhCS-A element binds two ubiquitous proteins of 100 kDa and 47 kDa respectively, whereas CRElhCS-B interacts only with the 47 kDa protein. Taken together, these results suggest that a 47 kDa protein binding to the CRElhCS-A and CRElhCS-B elements is involved in the PMA response of the hCS-A and hCS-B genes, and a 100 kDa protein plays a crucial role in cAMP regulation of the hCS-A gene. [less ▲]

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See detailSuivi satellitaire de la migration automnale de la cigogne noire. Aléas et perspectives d'avenir
Libois, Roland ULg; Jadoul, Gérard

in Aves (1997), 34(1), 20-22

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See detailExpression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines.
Gilles, Christine ULg; Polette, M.; Birembaut, P. et al

in Clinical & Experimental Metastasis (1997), 15(5), 519-26

We have previously observed in vitro that some stromal proteinases (MMP-2, MT1-MMP) were expressed or activated by invasive carcinoma cell lines exhibiting mesenchymal features, presumably acquired ... [more ▼]

We have previously observed in vitro that some stromal proteinases (MMP-2, MT1-MMP) were expressed or activated by invasive carcinoma cell lines exhibiting mesenchymal features, presumably acquired through an epithelial to mesenchymal transition (EMT). To examine the potential contribution of c-ets-1 to this phenotype, we have compared here the expression of c-ets-1 with invasiveness in vitro and expression of vimentin, E-cadherin, uPA, MMP-1 and MMP-3 in a panel of human breast cancer cell lines. Our results clearly demonstrate an association between c-ets-1 expression and the invasive, EMT-derived phenotype, which is typified by the expression of vimentin and the lack of E-cadherin. While absent from the two non-invasive, vimentin-negative cell lines, c-ets-1 was abundantly expressed in all the four vimentin-positive lines. However, we could not find a clear quantitative or qualitative relationship between the expression of c-ets-1 and the three proteinases known to be regulated by c-ets-1, except that when they were expressed, it was only in the invasive c-ets-1-positive lines. UPA mRNAs were found in three of the four vimentin-positive lines, MMP-1 in two of the four, and MMP-3 could not be detected in any of the cell lines. Intriguingly, MDA-MB-435 cells, which exhibit the highest metastatic potential of these cell lines in nude mice, expressed vimentin and c-ets-1, but lacked expression of these three proteinases, at least under the culture conditions employed. Taken together, our results show that c-ets-1 expression is associated with an invasive, EMT-derived phenotype in breast cancer cells, although it is apparently not sufficient to ensure the expression of uPA, MMP-1 or MMP-3, in the vimentin-positive cells. Such proteases regulation is undoubtedly qualified by the cellular context. This study therefore advances our understanding of the molecular regulation of invasiveness in EMT-associated carcinoma progression, and suggests that c-ets-1 may contribute to the invasive phenotype in carcinoma cells. [less ▲]

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See detailFin du Millénaire - fin de l'Agriculture
Schirmer, Jacek; Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (1997), 33

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See detailTechnique for long-term catheterization of large abdominal vessels in growing cattle.
Hornick, Jean-Luc ULg; Istasse, Louis ULg

in Contemporary Topics in Laboratory Animal Science (1997), 36(2), 66-8

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See detailOptimisation et application de la RAPD (random amplified polymorphic DNA) dans un programme de selection recurrente chez le cotonnier (Gossypium spp.).
Vroh Bi, I.; Du Jardin, Patrick ULg; Mergeai, Guy ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(2),

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See detailProtéinas placentárias em mamíferos
Melo de Sousa, Noelita; de Figueiredo, José Ricardo; Gonçalves, Paulo Bayard Dias et al

in Ciência Animal (1997), 7(1), 43-55

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins ... [more ▼]

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins, placental lactogens, interferon tau, pregnancy specific and pregnancy-associated glycoproteins. In spite of the importance of these studies, there are few papers that describe fundamental aspects of these placental proteins such as physical-chemical pregnancy diagnosis methods. Thus, the aim of this report is to present an overview on the major aspects of placental proteins studied up to now, as well as to consider perspectives for their applications in the future in veterinary practice. [less ▲]

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See detailBiomechanical assessment of the transversalis fascia and rectus abdominis aponeurosis in inguinal herniation - Preliminary results
PANS, Alain ULg; Pierard, Gérald ULg; Albert, Adelin ULg et al

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (1997), 1

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See detailIndependent prognostic value of the 67-kd laminin receptor in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Menard, Sylvie et al

in Journal of the National Cancer Institute (1997), 89(16), 1224-7

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See detailInventaire forestier régional et applications cartographiques.
Rondeux, Jacques ULg; George, B.; Lecomte, Hugues

in Silva Belgica (1997), 104(3),

Il est pratiquement possible de représenter, par voie cartographique, tous les résultats issus d'un inventaire réalisé par échantillonnage, que ce soit en termes de variables quantitatives réparties en ... [more ▼]

Il est pratiquement possible de représenter, par voie cartographique, tous les résultats issus d'un inventaire réalisé par échantillonnage, que ce soit en termes de variables quantitatives réparties en classes d'amplitudes fixées ou de variables qualitatives codées sur une échelle de valeurs prédéfinie. A la condition d'être de type systématique [RONDEUX, 1993], cet échantillonnage assure une représentation cartographique homogène d'autant plus fine, lisible et fiable que la maille définissant l'emplacement des unités de sondage est dense et que la variabilité de l'élément ou de la variable à illustrer est faible. La localisation géographique de l'information, en particulier forestière, permet de donner une autre dimension aux résultats et offre d'évidentes perspectives de valorisation de ceux-ci, en particulier lorsqu'il s'agit de problèmes relevant de la gestion de l'espace et de stratégies touchant son organisation à une large échelle. Ces propos sont illustrés par la réalisation de cartes relatives à une situation photographiée par le premier inventaire forestier wallon mis en oeuvre [RONDEUX, 1988] entre 1980 et 1984. Elles concernent, à titre d'exemple et compte tenu des contraintes exposées au paragraphe 2, la répartition entre propriétés publiques et privées, les types de peuplement (feuillus ou résineux) et la structure de ceux-ci, les volumes à l'hectare de la totalité du matériel ligneux vivant et les niveaux de productivité des peuplements d'épicéa commun. Nous envisagerons sur un plan général le type de relations unissant un inventaire par échantillonnage à une représentation cartographique thématique (paragraphe 2), nous présenterons ensuite les documents proposés après avoir précisé la définition aussi stricte que possible des variables entrant en ligne de compte (paragraphe 3) avant de terminer par une brève conclusion (paragraphe 4). [less ▲]

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See detailSynthesis of resorcinol-formaldehyde aeroels by the freeze-drying methods
Mathieu, Bernard; Michaux, Bernard; Pirard, René ULg et al

in Annales de Chimie Science des Materiaux (1997), 22

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See detailMulticité. Le jeu du développement urbain
Beckers, Jacqueline ULg; Demeuse, Yves; Merenne-Schoumaker, Bernadette ULg et al

in G.E.O. (1997), 41(Numéro spécial),

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la ... [more ▼]

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la maximisation des retombées pour la collectivité ; elle fait appel à des bureaux d’études qui doivent monter ces projets. Le jeu se joue sur un territoire (plateau de jeu) avec ses quartiers d’habitat, son centre, ses réseaux de communication et aussi 350 îlots colorés selon l’affectation du sol et leur statut (public et privé). Le jeu – qui se déroule aussi sur deux fois 50 minutes dans sa version courte (un projet) – permet d’abord à l’équipe municipale de définir ses critères de choix et aux bureaux d’étude de monter leur projet, il met ensuite les protagonistes en contact puis en débat avant le choix final. Outre le plateau figurant le territoire, le jeu comprend encore des fiches relatives aux équipements, des consignes particulières pour les membres du bureau d’études et de l’équipe municipale (dont une fiche budget et une fiche argumentaire). À l’issue du jeu, il est possible non seulement de mettre en évidence les facteurs de localisation des équipements mais également le jeu des acteurs et les contraintes d’une politique de développement communal. [less ▲]

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See detailCharacterization of the IGF system and analysis of the possible molecular mechanisms leading to IGF-II overexpression in a mesothelioma.
Hodzic, D.; Delacroix, Laurence ULg; Willemsen, P. et al

in Hormone & Metabolic Research (1997), 29(11), 549-55

The expression of members of the IGF system in a mesothelioma from a patient suffering from hypoglycemia, in term placenta and HT29 colon adenocarcinoma cells were compared. Very high levels of IGF-II ... [more ▼]

The expression of members of the IGF system in a mesothelioma from a patient suffering from hypoglycemia, in term placenta and HT29 colon adenocarcinoma cells were compared. Very high levels of IGF-II mRNA and protein were detected in the mesothelioma. Moreover, half of the IGF-II protein took the high-molecular-weight form. We also analyzed the parental imprinting status and the promoter usage of the IGF-II gene. Our results showed loss of imprinting (LOI) in the mesothelioma while the imprinting was maintained in HT29 cells, expressing moderate levels of the transcript. Promoter P4 was active in the three tissues we analyzed, whereas IGF-II mRNA transcription from promoter P3 was only detected in the mesothelioma and the placenta, expressing comparably high levels of the transcript. IGF-II gene structure was identical in the analyzed tissues and cells. The type-I receptor mRNA expression was very low in the tumor. IGFBP-2, -4 and -5 mRNAs were detected in the mesothelioma, while IGFBP-2, -3 and -5 transcripts were detected in the placenta. IGFBP-1 and -6 transcripts were not detected. [less ▲]

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See detailBovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro
Hulshof, S. C. J.; Figueiredo, J. R.; Beckers, Jean-François ULg et al

in Theriogenology (1997), 48

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral ... [more ▼]

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantal follicles. In addition, activin immunoreactivity was observed in the theca of secondary follicles. In addition, activin preantral follicles, activin increased follicular growth and granulosa cell proliferation in a dose-dependent manner. This increase was further stimulated by addition of FSH. In conclusion, activin and its receptor are present on bovine follicles, and additional activin stimulates development of those follicles. [less ▲]

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See detailIntellectuels malgré eux
Denis, Benoît ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1997), (79-81), 49-52

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See detailCharacterization of CuInTe2 thin films prepared by flash evaporation
Boustani, M.; El Assali, K.; Bekkay, T. et al

in Semiconductor Science & Technology (1997), 12

Thin films of CuInTe2 were grown by flash evaporation. The influence of the substrate temperature Ts during film deposition on the properties of the thin films was examined. CuInTe2 films were ... [more ▼]

Thin films of CuInTe2 were grown by flash evaporation. The influence of the substrate temperature Ts during film deposition on the properties of the thin films was examined. CuInTe2 films were structurally characterized by the grazing incidence x-ray diffraction (GIXD) technique. Investigation by this technique demonstrates that the surface of thin films of CuInTe2 prepared by flash vaporation at Ts > 100 °C exhibits the chalcopyrite structure with additional binary compounds in the surface. However, in the volume the films exhibit the chalcopyrite structure only; no foreign phases were observed. X-ray reflectometry was utilized to evaluate the critical reflection angle bc of CuInTe2 (bCuInTe2 c 0.32°) which permitted us to calculate the density of the films to be 6 g cm−3. The evaporated films were p type and the films deposited at Ts = 100 °C had a resistivity in the range 0.3–2 cm. From optical measurements we have determined the optical energy gap Eg 0.94 eV and the effective reduced mass m*r 0.07me . [less ▲]

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See detailHemodynamic effects of increasing PEEP during mechanical ventilation in anesthetized patients
LAMBERMONT, Bernard ULg; Ghuysen, Alexandre ULg; D'Orio, Vincenzo ULg et al

in American Journal of Respiratory & Critical Care Medicine (1997), 2

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See detailEvolution of coronary atherosclerosis in patients with mild coronary artery disease studied by serial quantitative coronary angiography at 2 and 4 years follow-up. The Multicenter Anti-Atheroma Study (MAAS) Investigators.
Vos, J.; de Feyter, P. J.; Kingma, J. H. et al

in European heart journal (1997), 18(7), 1081-9

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The ... [more ▼]

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The objective of this study was to describe the natural course of focal and diffuse coronary atherosclerosis over time. METHODS AND RESULTS: In 129 patients with mild coronary artery disease, but not on lipid-lowering medication, three coronary angiograms were made each 2 years apart. Nine hundred and sixty five angiographically diseased and non-diseased segments were analysed by quantitative coronary angiography. Mean lumen diameter and minimal lumen diameter were used as measures of diffuse and focal coronary atherosclerosis. Mean lumen diameter and minimum lumen diameter decreased by 0.02 and 0.03 mm per year. The rate of progression was similar in the angiographically non-diseased, as in the mildly and moderately diseased segments. Progression of diffuse coronary atherosclerosis was largest in severely stenosed lesions (percentage diameter stenosis > or = 50%) and in the right coronary artery with a loss of 0.19 mm and 0.16 mm in mean lumen diameter. Progression of focal disease was most prominent in new and mild lesions and the right coronary artery, with a decrease in minimum lumen diameter of 0.34 mm and 0.22 mm. In most subgroups, progression occurred gradually over time. On a per segment level, progression and the occurrence of new lesions occurred in 4.4% and 4.2%. Regression and disappearance of a lesions was found in 2.3% and 1.9%. On a per patient level, 36% were progressors, 12% had a mixed response, 36% were stable, and 16% were regressors. CONCLUSION: Diffuse and focal coronary atherosclerosis progressed at the same rate in the first and second 2 years in stenosed and non-stenosed segments. The rate of coronary atherosclerosis progression was small, but was higher for focal than for diffuse disease. A minority of lesions progressed and spontaneous regression was rare. [less ▲]

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See detailLa violence dans les stades de football
Comeron, Manuel ULg

in Revue Générale (1997), (2), 21-30

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See detailFreeze-dried resorcinol-formaldehyde gels
Blacher, Silvia ULg; Pirard, René ULg; Pirard, Jean-Paul ULg et al

in Journal of Non-Crystalline Solids (1997), 212(2-3), 250-261

The texture of resorcinol-formaldehyde gels, previously synthesized by Pekala et al. [1-6], but dried by freeze-drying was studied. The freeze-dried gels present a complex porous structure from nanometer ... [more ▼]

The texture of resorcinol-formaldehyde gels, previously synthesized by Pekala et al. [1-6], but dried by freeze-drying was studied. The freeze-dried gels present a complex porous structure from nanometer to micrometer length-scale. Taking a standard freezing rate, we study in detail the influence of the molar ratio resorcinol/catalyst on the texture, This molar ratio is one of the parameters under consideration which can lead to a tailoring of the dried gel texture in order to develop adsorbents or catalyst supports of controlled porosity. Characterization methods include nitrogen adsorption-desorption (including the classical and the fractal interpretations), mercury porosimetry, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). [less ▲]

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See detailImmunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Donnez, Jacques

in Fertility and Sterility (1997), 68(5), 912-919

Objective: To assess the proliferative activity of eutopic and ectopic endometrium throughout the menstrual cycle and its correlation to steroid receptor content. Design: The immunohistochemical use of Ki ... [more ▼]

Objective: To assess the proliferative activity of eutopic and ectopic endometrium throughout the menstrual cycle and its correlation to steroid receptor content. Design: The immunohistochemical use of Ki 67 was applied to investigate the proliferation index. A recently advanced stereographic computer technology was used to investigate steroid receptors. Setting: University hospital department of gynecology. Patient(s): Biopsies of eutopic endometrium, black and red peritoneal endometriotic lesions, and ovarian endometriomas were taken from infertile patients and classified according to the phase of the cycle. Result(s): In normal endometrium, the glandular proliferation index was highest during the proliferative phase and was statistically significantly reduced during the secretory phase. No proliferative activity was observed in the late secretory phase. No statistically significant differences were found between ectopic endometrium and eutopic endometrium except during the late secretory phase, when proliferative activity was still present in endometriotic tissue. The stromal proliferation index was similar in red lesions, ovarian endometriomas, and eutopic endometrium during the secretory phase. In normal endometrium, the highest concentrations of estrogen receptors (ERs) and P receptors (PRs) occurred in the epithelial and stromal cells during the late proliferative phase of the menstrual cycle. Estrogen receptor and PR content declined throughout the secretory phase. In ectopic endometrium, PR persisted in the glandular epithelium during the late secretory phase. Estrogen receptors persisted in the glandular epithelium and stroma of red peritoneal lesions and ovarian endometriomas during the late secretory phase. Conclusion(s): The high proliferative activity and the persistence of ERs and PRs in the stroma of red lesions and ovarian endometriomas emphasize the primordial role of the stroma in the development of endometriosis and suggest different mechanisms of proliferation control from those observed in eutopic endometrium. [less ▲]

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See detailEtat de nécessité et damnum incendii arcendi causa datum
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité [= RIDA] (1997), 44

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See detailProgesterone receptors (PR) in ectopic endometrium?
NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (1997), 68(5), 943-4

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See detailPreuve et conséquences de la séparation de fait en matière d’assujettissement et d’établissement de l’impôt des personnes physiques
Orban, Lionel ULg

in Commission Université-Palais – Formation permanente – Droit fiscal. Volume XIV – Février 1997 (1997)

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See detailThe relationship between ovarian vascularity and the duration of stimulation in in-vitro fertilization.
Bassil, Salim; Wyns, Christine; Toussaint-Demylle, Dominique et al

in Human Reproduction (1997), 12(6), 1240-5

The role of transvaginal pulsed colour Doppler ultrasound in the assessment of ovarian vascularity was studied in 196 in-vitro fertilization (IVF) cycles. The changes in ovarian blood flow after ... [more ▼]

The role of transvaginal pulsed colour Doppler ultrasound in the assessment of ovarian vascularity was studied in 196 in-vitro fertilization (IVF) cycles. The changes in ovarian blood flow after gonadotrophin-releasing hormone agonist (GnRHa) down-regulation and human menopausal gonadotrophin (HMG) stimulation were determined. The data obtained showed that the ovarian blood flow was significantly improved by oestradiol secretion (P = 0.05) and human chorionic gonadotrophin (HCG) administration (P = 0.003). Folliculogenesis was affected by blood flow supply. The resistance index (RI) value was significantly different (P = 0.05) according to the duration of ovarian stimulation. Patients with a mean RI value >0.56 had a longer stimulation with a significantly lower mean number of oocytes retrieved (P = 0.01) despite the administration of a standard dose of HMG. The RI value is a good indicator of modifications in ovarian vascularization during stimulation. Doppler blood flow measurement could be used to determine the optimal timing for the beginning of HMG administration in patients undergoing ovarian stimulation after down-regulation for IVF treatment. [less ▲]

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See detailDe différences en disparités : les effets d'un système éducatif 'non compréhensif'
Lafontaine, Dominique ULg

in Scientia Paedagogica Experimentalis (1997), XXXIV(2), 267-281

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique ... [more ▼]

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique, organisation en tronc commun ou en filières, présence ou non d'une carte scolaire) et différents indices de performance ou d'équité : performances moyennes en lecture à un test international comparatif, degré d'hétérogénéité des performances entre élèves, disparités de rendement selon l'établissement ou la filière fréquenté(e). Les résultats montrent que le redoublement, largement pratiqué en Communauté française de Belgique, ne débouche ni sur des meilleures performances, ni sur une réduction sensible des disparités entre élèves. L'absence de tronc commun et de sectorisation engendre en outre de fortes disparités selon la filière et selon l'établissement fréquenté. Le premier degré du secondaire de la Communauté française, organisé en système 'non compréhensif', semble ainsi de nature à amplifier plutôt qu'à corriger les inégalités entre élèves issus du primaire. [less ▲]

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See detailFibres alimentaires chez le chien : influence de l'incorporation de pulpes de betterave ou de chicorée sur la digestibilité des nutriments et les concentrations plasmatiques de plusieurs métabolites
Diez, Marianne ULg; Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg et al

in Revue de Médecine Vétérinaire (1997), 148

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres ... [more ▼]

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres fécaux, la digestibilité des principaux nutriments et plusieurs paramètres biochimiques (glucose, insuline, azote alpha-aminé, urée, cholestérol et triglycérides) mesurés à jeun ou pendant six heures après le repas chez huit chiens adultes en bonne santé. Les régimes enrichis en pulpes ont entraîné une augmentation significative de l'excrétion fécale totale, de l'excrétion de MS dans les matières fécales, une diminution de la teneur en MS des fèces ainsi qu'une diminution des coefficients de digestibilité des principaux nutriments. Le régime contenant la pulpe de betterave a entraîné une diminution de la glycémie à jeun, de l'insulinémie et des concentrations en triglycérides postprandiales, des concentrations en urée et en cholestérol mesurées avant et après le repas. Le régime contenant la pulpe de chicorée a provoqué une diminution de l'insulinémie postprandiale, des concentrations en urée et en cholestérol à jeun et après le repas. Ces deux types de pulpes, semblables par leur composition, induisent les mêmes types d'effets sur les paramètres fécaux et la digestibilité des nutriments, mais les effets systémiques sont plus importants lors de la distribution de pulpes de betterave. [less ▲]

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See detailAirborne dust and aeroallergen concentrations in different sources of feed and bedding for horses
Vandenput, Sandrina ULg; Istasse, Louis ULg; Nicks, Baudouin ULg et al

in Veterinary Quarterly (The) (1997), 19(4), 154-158

Standardized methods were used to make quantitative and qualitative assessments of respirable dust and aeroallergens in feed and bedding for horses. Concentrations of airborne dust were measured by using ... [more ▼]

Standardized methods were used to make quantitative and qualitative assessments of respirable dust and aeroallergens in feed and bedding for horses. Concentrations of airborne dust were measured by using a Rion particle counter, and levels of major aeroallergens implicated in chronic obstructive pulmonary disease were measured by using an Andersen sampler. Laboratory conditions allowed comparison of the different sources of forage, supplements, and bedding without external influences such as ventilation, external temperature and horse activity affecting the result. Grass silages of approximately 50% dry matter and alfalfa pellets appeared to be very good sources of forage with low levels of dust and aeroallergens. The studied good quality straw was significantly less dusty with fewer allergens than the wood shavings. Supplements, such as whole grains and molassed concentrates, contained many respirable particles and aeroallergens. Rolled grains were significantly more dusty than good hay. [less ▲]

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See detailCell-line specific radiosensitizing effect of zalcitabine (DDC)
Coucke, Philippe ULg; Li, Ye-Xiong; Copaceanu, Marie-Laure et al

in Acta Oncologica (1997)

The potential of zalcitabine (ddC) to act as an ionizing radiation response modifier was tested on exponentially growing human cancer cells in vitro. Two human cell lines, WiDr (colon) and MCF-7 (breast ... [more ▼]

The potential of zalcitabine (ddC) to act as an ionizing radiation response modifier was tested on exponentially growing human cancer cells in vitro. Two human cell lines, WiDr (colon) and MCF-7 (breast) were exposed to ddC at 10 p M concentration for various lengths of tide (18, 24, 48 and 72 h). On the WiDr cell line the dual effect of concentration and duration of exposure prior to irradiation was investigated. Experimental endpoints were clonogenicity and viability, as measured by colony formation assay (CFA) and MTT assay respectively. The impact on cell-cycle distribution prior to irradiation was assessed by flow cytometry using a double labeling technique (propidium iodide and bromodeoxyuridine pulse label). A significant reduction in surviving fraction and viability was observed for WiDr-cells irradiated after pre-exposure to 10 pM for 18, 48 and 72 h as compared to corresponding irradiated controls. At lower concentrations (1 and 5 pM), the radiosensitizing effect was only significant after a 72-h exposure (assessed by CFA). For MCF-7, ddC induced a significant modification of the dose response only with 24 and 48 h preincubation. However, the overall effect was less pronounced as compared to WiDr. Cell-cycle analysis showed accumulation in S-phase, 48 and 72 h after treatment with 10 pM ddC in the WiDr cells, with a progressive shift to late S-phase as shown by the biparametric analysis. The degree of radiosensitization is cell-line dependent with the most important sensitization observed on the most <<radioresistant cell line>>, ix., the cell line with the lowest alpha value and highest SF 2 (WiDr). For WiDr, radiosensitization by ddC depends on the duration of exposure and the concentration of the drug. Received 29 February 1996 Accepted 10 December 1996 [less ▲]

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See detailNaCl salinity and temperature effects on growth of three wood-rotting basidiomycetes from a Papua New Guinea coastal forest
Castillo Cabello, Gabriel ULg; Demoulin, Vincent ULg

in Mycological Research (1997)

The growth of three wood inhabiting basidiomycetes (Microporus xanthopus, Pycnoporus sanguineus and Schizophyllum commune) isolated from a tropical coastal forest of Papua New Guinea is characterized in ... [more ▼]

The growth of three wood inhabiting basidiomycetes (Microporus xanthopus, Pycnoporus sanguineus and Schizophyllum commune) isolated from a tropical coastal forest of Papua New Guinea is characterized in relation to temperature and NaCl salinity. P. sanguineus and M. xanthopus present a very similar response to NaCl salinity, but P. sanguineus has a wider tolerance for temperature variations. S. commune withstands wide temperature variations, but it is the only one to present a marked salt resistance. This correlates with its abundance along the sea. The presence of P. sanguineus in the same habitat is rather unexpected since it is very sensitive to NaCl salinity. Its high growth rate probably allows it to take advantage of periods of high rains that limit salt accumulation. [less ▲]

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See detailClostridium spiroforme toxin genes are related to C. perfringens iota toxin genes but have a different genomic localization.
Gilbert, M.; Perelle, S.; Daube, Georges ULg et al

in Systematic & Applied Microbiology (1997), 20

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See detailPEGASE, une méthodologie et un outil de simulation prévisionnelle pour la gestion de la qualité des eaux de surface
Smitz, Joseph ULg; Everbecq, Etienne ULg; Deliège, Jean-François ULg et al

in Tribune de l'Eau (La) (1997), 50/4(588), 73-82

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle ... [more ▼]

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle la qualité des eaux des rivières en fonction des rejets et apports de pollution. PEGASE est un outil opérationnel permettant d’orienter les choix des opérateurs publics et privés en matière de gestion des eaux de surface à l’échelle des bassins versants [less ▲]

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See detailAnti-PMSG in sheep subjected annualy to oestrus synchronisation
Bodin, L.; Drion, Pierre ULg; Remy, Benoit et al

in Reproduction Nutrition Development (1997), 37

Estimation of the long-term consequences on reproduction performance of the oestrus synchronisation treatments that are annually applied to ewes was carried out on nine officially controlled dairy flocks ... [more ▼]

Estimation of the long-term consequences on reproduction performance of the oestrus synchronisation treatments that are annually applied to ewes was carried out on nine officially controlled dairy flocks in the Roquefort region of France. A hormonal treatment combining the insertion of a vaginal fluoro-gestone acetate (FGA) sponge for 14 days and the injection of about 500 IU of pregnant mare serum gonadotropin (PMSG) at withdrawal was applied to the ewes in seven of the nine flocks. The ewes in the two other flocks were used as controls. Blood samples were taken from each female just before the treatment (to test for the presence of residual antibodies) and 20 days after the PMSG injection. Anti-PMSG antibody binding rates were calculated for each blood sample. The residual binding rate increased with age and induce negative effects on the following years reproduction performances, ie, they increased the probability that the ewes would not become pregnant. [less ▲]

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See detailQuelques données inédites sur l'accroissement des peuplements de hêtre en Région wallonne.
Rondeux, Jacques ULg; Lecomte, H.; Florkin, P. et al

in Silva Belgica (1997), 104(5), 7-14

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See detailCharacterization of Clostridium perfringens isolated from necrotic enteritis of fowls.
Das, B. C.; Dutta, G. N.; Daube, Georges ULg et al

in Indian Journal of Animal Sciences (The) (1997), 67

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See detailQuelle est la place de l’Université dans notre société ?
Brunet, Sébastien ULg

in Revue l’Observatoire (1997), 15

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See detailNon délivrance et infécondité: intérêts de l’étiproston et du dosage de la PAGI (pregnancy-associated glycoprotein I) au cours du postpartum chez la vache.
Zaiem, I.; Tainturier, D.; Ben Othmen, H. et al

in Revue de Médecine Vétérinaire (1997), 148(8-9), 725-732

Sixty Prim'holstein cows with retained placenta for more than 24 hours after parturition, were shared in three groups of 20 cows each. All cows were delivred manually 24 to 36 hours post partum and ... [more ▼]

Sixty Prim'holstein cows with retained placenta for more than 24 hours after parturition, were shared in three groups of 20 cows each. All cows were delivred manually 24 to 36 hours post partum and received local treatment with 1 g of oxytetracyclin. Cows in group 1 received two intra-muscular injections of 5 mg etiproston on day of manual delivery (D1) and 15 days after (D15). Cows on group II received only one etiproston administration (D1), and cows in group III remained untreated. Ratios of delayed uterine involution were respectively 20, 40 and 55 % in groupsI,II and III(I<0.05;II<0.005). PAGI concentrations were checked 15 days after parturition and were significantly higher in cows affected by delayed uterine involution (p < 0.05). V-IAF intervals were significantly (p < 0.05) different between groups I (58 days), II (102 days) and III(143 days). [less ▲]

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See detailDetermination rapide par immunodosage de l'hemoglobine glyquee sur sang capillaire comparee a une methode d'affinite pour le boronate et capture d'ions sur sang veineux.
Bozet, Marie-Claire ULg; Gerard, Pascale ULg; Scheen, André ULg et al

in Annales de Biologie Clinique (1997), 55(2), 139-44

Measurement of glycosylated haemoglobin has become an essential tool in the management of diabetic patients. A recently developed device allows the rapid immuno-assay of HbA1c in 1 microliter capillary ... [more ▼]

Measurement of glycosylated haemoglobin has become an essential tool in the management of diabetic patients. A recently developed device allows the rapid immuno-assay of HbA1c in 1 microliter capillary blood obtained by a finger prick. In 100 ambulatory diabetic patients, we compared the results obtained with this method to those obtained in venous blood using a standard affinity chromatography laboratory method. Although both methods correlated (r = 0.88, p < 0.001), the mean +/- SD levels respectively obtained differed slightly (7.6 +/- 1.5 vs 79 +/- 1.4% p < 0.001). The 95% confidence interval of the difference was [-0.41. -0.14]. Considering a cut-off HbA1c value of 8%, as indicative of the need for treatment adjustment, 33 patients with the capillary blood immuno-assay method and 42 with the venous-blood affinity chromatography method were above that limit (Mc Nemar test, p < 0.05). In conclusion, the rapid assay of HbA1c in capillary blood can be useful for the management of some diabetic patients but the results are not readily exchangeable with those obtained from other standardized laboratory methods. Consequently, specific ranges and clinical decision limits must be determined. [less ▲]

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See detailEvidence For The Assignment Of Two Strains Of Splv To The Genus Potyvirus Based On Coat Protein And 3' Non-Coding Region Sequence Data
Colinet, Dominique; Kummert, Jean; Lepoivre, Philippe ULg

in Virus Research (1997), 49(1), 91-100

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See detailExpression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions
Kokorine, Isabelle; NISOLLE, Michelle ULg; Donnez, Jacques et al

in Fertility and Sterility (1997), 68(2), 246-251

Objective: To determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the pathogenesis of endometriosis ... [more ▼]

Objective: To determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the pathogenesis of endometriosis. Design: Serial sections of peritoneal red and black endometriotic lesions, ovarian endometriotic cysts, and rectovaginal adenomyotic nodules were analyzed by in situ hybridization for the expression of matrix metalloproteinase-1 by silver staining for the integrity of the fibrillar extracellular matrix and by immunolabeling for the abundance of sex steroid receptors. Setting: Academic hospital and research laboratory. Patient(s): Premenopausal women undergoing laparoscopy for endometriosis. Intervention(s): Biopsy of endometriotic lesions, combined with endometrium whenever possible. Main Outcome Measure(s): Expression of matrix metalloproteinase-1 messenger RNA (mRNA). Result(s): Matrix metalloproteinase-1 mRNA was expressed focally in red peritoneal and ovarian endometriosis irrespective of the phase of the menstrual cycle but was not detectable in black peritoneal and rectovaginal lesions. Foci of matrix metalloproteinase-1 expression closely correlated with matrix breakdown and with the absence of P receptors in adjacent epithelial cells. Conclusion(s): Correlation of matrix metalloproteinase-1 expression with activity of endometriotic tissue suggests its involvement in tissue remodeling and bleeding, and possibly in the secondary shedding and reimplantation of endometriotic lesions. [less ▲]

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See detailDietary fibre in dogs diet : comparisons between cellulose, pectin, guar gum, and between two incorporation rates of guar gum
Diez, Marianne ULg; Van Eenaeme, Christian ULg; Hornick, Jean-Luc ULg et al

in Journal of Animal Physiology & Animal Nutrition (1997), 78

Ausgewachsene Beagle-Hunde erhielten eine Kontrolldiaet (I) aus Hackfleisch und Reis oder mit Cellulose (II), Pektin (III) bzw. Guar (IV) angereicherte Diaeten mit einem Anteil von 3.4% in der ... [more ▼]

Ausgewachsene Beagle-Hunde erhielten eine Kontrolldiaet (I) aus Hackfleisch und Reis oder mit Cellulose (II), Pektin (III) bzw. Guar (IV) angereicherte Diaeten mit einem Anteil von 3.4% in der Trockenmasse. Bei Diaet IV tendierte die Magenentleerungsrate zu niedrigeren Werten. Die intestinale Absorption von Xylose wurde durch die Diaeten IV und III nicht beeinflusst, aber durch Diaet II sign. verlangsamt. Die Varianten III und IV fuehrten zu geringeren Trockenmassegehalten im Kot(p less than 0.001). Die zugefuehrten Faserstoffe senkten teilweise die Naehrstoffverdaulichkeit. Die preprandialen Plasmakonzentrationen an Glucose, Insulin, alpha-Amino-N, Harnstoff und Triglyceriden blieben unbeeinflusst. Die Diaet IV bewirkte einen deutlichreduzierten postprandialen Anstieg von alpha-Amino-N (p less than 0.05) und Harnstoff (p less than 0.01) im Plasma sowie geringere Cholesteringehalte bei gefuetterten und nuechternen Tieren (p less than 0.05). Ein weiterer Versuch mit 3.5% bzw. 7% Guaranteil in der Diaet zeigte dosisabhaengige Effekte. [less ▲]

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See detailEndoscopic laser treatment of uterine malformations.
Donnez, Jacques; NISOLLE, Michelle ULg

in Human Reproduction (1997), 12(7), 1381-7

Hysteroscopic resection of an intrauterine septum may benefit patients suffering from infertility or recurrent pregnancy loss. A partial or complete uterine septum can be easily resected using a Nd-YAG ... [more ▼]

Hysteroscopic resection of an intrauterine septum may benefit patients suffering from infertility or recurrent pregnancy loss. A partial or complete uterine septum can be easily resected using a Nd-YAG laser. If present, the vaginal septum may also be removed during the same procedure. The reproductive outcome of women treated by operative hysteroscopy for an intrauterine septum is reviewed. To avoid pregnancy in a non-communicating rudimentary horn, the removal of the horn and the homolateral tube may be performed by either bipolar coagulation or a CO2 laser. [less ▲]

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See detailOrigine des produits animaux et empreinte génétique
Portetelle, Daniel ULg; Mortiaux, Frédéric; Burny, Arsène et al

in Agricontact (1997), 294

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See detailCombined Ring Inversion and Side Group Rotation in Geminal Diphosphoryl Substituted Pyrrolinoxyl Radicals: ESR Analysis of Chemical Exchange between Four Nonequivalent Sites
Rockenbauer, Antal; Mercier, Anne; Le Moigne, François et al

in Journal of Physical Chemistry A (1997), 101(43), 7965-7970

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found ... [more ▼]

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found, for the 2,2-disubstituted compounds 2 and 3, dramatic changes in the spectra were observed as a function of the temperature. These changes were explained by a four-site chemical exchange model including both ring inversion and hindered rotation around the carbon-phosphorus bonds. For radical 3, the presence of additional 5,5-dimethyl substitution can completely block rotations around carbon-phosphorus bonds for certain ring geometries, while for other ring conformations chemical exchange still occurs through combined inversionrotation processes. An effective two-site model composed of nonequivalent sites and a superposition model composed of a pair of exchanging conformers and a pair of nonexchanging conformers were used to simulate spectrum variations. A satisfactory fit was obtained over the entire temperature range investigated. From the temperature dependence of the exchange frequencies the potential barriers for ring inversion (27 kJ/mol), for combined inversion-rotation (11 kJ/mol), and for rotation around the carbon-phosphorus bonds (14 kJ/mol) were estimated. [less ▲]

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See detailInfluence of a blend of fructo-oligosaccharides and sugar beet fiber on nutrient digestibility and plasma metabolites concentrations in healthy Beagles
Diez, Marianne ULg; Hornick, Jean-Luc ULg; Baldwin, Paule ULg et al

in American Journal of Veterinary Research (1997), 58

Objective-To evaluate effects of a blend of fructo-oligosaccharides and sugar beet fiber (4:1) at 3 incorporation rates on nutrient digestibility and plasma glucose, insulin, alpha-aminonitrogen, urea ... [more ▼]

Objective-To evaluate effects of a blend of fructo-oligosaccharides and sugar beet fiber (4:1) at 3 incorporation rates on nutrient digestibility and plasma glucose, insulin, alpha-aminonitrogen, urea, cholesterol, and triglycerides concentrations measured weekly in nonfed dogs and during a 360-minute period after a meal. Animals-8 castrated 1 to 1.4-year-old young adult male Beagles weighing 10.0 to 13.5 kg. Procedure-Diets containing 2 incorporation rates of a blend of fructo-oligosaccharides and sugar beet fiber (5 and 10% on a dry matter basis [diets B and C, respectively]) were compared with a control diet without additional fiber (diet A). The 3 diets were evaluated for ability to modify digestibility of dry and organic matter, protein, fat, and ash and for effects on plasma glucose, insulin, alpha-aminonitrogen, urea, cholesterol, and triglycerides concentrations. Each diet was fed for 6 weeks; plasma samples were collected weekly before feeding and after feeding on the last day of the period, During 1 week at the end of the 6-week period, dogs were kept in metabolic cages. Each period of the block was followed by a 4-week washout period. Results-Incorporating the blend of fructo-oiigosaccharides and sugar beet fiber in the diet was associated with greater passage of wet feces (diets B and C) and lower protein digestibility (diet C). Postprandial glucose (diet C), urea (diets B and C) and triglyceride (diets B and C) concentrations were significantly (P < 0.01) decreased. Weekly preprandial measurements were characterized by decreased urea (diets B and C), cholesterol (diet C), and triglycerides (diets B and C) concentrations (P < 0.001). Conclusion-Chronic consumption of fermentable fiber is associated with mildly decreased protein digestibility and with metabolic effects in nonfed or fed dogs. Clinical Relevance-A blend of fructo-oligosaccharides and sugar beet fiber should he tested as a dietary aid for treatment of chronic diseases, such as diabetes mellitus or hyperlipidemia, in dogs. [less ▲]

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See detailGenetics and Inflammatory Bowel Disease: From Association Studies to Wide Genome Screen
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1997), 60(3, Jul-Sep), 201-3

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See detailBovine Herpesvirus 1-Induced Apoptosis Occurs At The G0/G1 Phase Of The Cell Cycle
Hanon, Emilien ULg; Hoornaert, S.; Dequiedt, Franck ULg et al

in Virology (1997), 232(2), 351-358

We have previously shown that bovine herpesvirus 1 (BHV-1), even when inactivated, induces apoptotic cell death in mitogen-stimulated bovine peripheral blood mononuclear cells (PBMCs) (Hanon et al., 1996 ... [more ▼]

We have previously shown that bovine herpesvirus 1 (BHV-1), even when inactivated, induces apoptotic cell death in mitogen-stimulated bovine peripheral blood mononuclear cells (PBMCs) (Hanon et al., 1996, J. Virol. 70, 4116-4120). In order to gain insight into this process, we have investigated the cell cycle phase at which BHV-1 induces apoptosis in PBMCs. Our results show that the percentage of cells that progress through the S phase was always lower in BHV-1-infected PBMCs than in control cells. This effect was not due to a defective activation of mitogen-stimulated PBMCs since BHV-1 only slightly affected the percentage of cells expressing BoCD25, a well-known lymphocyte activation marker. Furthermore, mimosine and cyclosporine A, two chemicals that inhibit entry into the S phase of the cell cycle by different pathways, did not affect the ability of BHV-1 to induce apoptosis. BHV-1-induced apoptosis also occurred in unstimulated PBMCs and interestingly, this was associated with the expression of c-myc and BoCD25 proteins both of which are related to cell cycle progression. All together, these data provide evidence demonstrating that BHV-1-induced apoptosis occurs at the G0/G1 phase of the cell cycle. [less ▲]

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See detailTiming effect of combined radioimmunotherapy and radiotherapy on a human solid tumor in nude mice.
Coucke, Philippe ULg; Lin-Quan, Sun; Vogel, Charles-André et al

in Cancer Research (1997), 57

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were ... [more ▼]

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were evaluated separately. Then, 30 Gy RT (10 fractions over 12 days) were combined with three weekly Lv. injections of 200 g@Ci of 131I-labeled anti-carcino embryonic antigen monoclonal antibodies in four different treatment schedules. RIT was given either prior to, concurrently, Immediately after, or 2 weeks after RT administration. The longest regrowth delay (RD) of 105 days was observed in mice treated by concurrent administration of RT and lilT, whereas the RDs of RT and RIT alone were 34 and 20 days, respectively. The three sequential combination treatments produced sig nificantly shorter RDs ranging from 62 to 70 days. The tumor response represented by the minimal volume (MV) also showed that concurrent administration of RT and RIT gave the best result, with a mean MV of 4.5% as compared to MVs from 26 to 53% for the three sequential treatments. The results were confirmed In a second experiment, In which a RT of 40 Gy was combined with an identical lilT as above (three injections of 200 g&Ci of ‘31I-labeled monoclonal antibodies). At compa rable toxicity levels, the maximum tolerated RT or BIT alone gave shorter RDs and less tumor shrinkage compared to slinultaneous RT+RIT. These results may be useful for designing clinical protocols ofcombined RIT and RT. [less ▲]

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See detailFibres alimentaires chez le chien : VII. Intérêt dans le traitement diététique de l'animal obèse
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The present review deals with obesity in the dog, Definition, incidence, assessment, etiology and detrimental effects of obesity are firstly presented. In a second part, the treatment is discussed, with ... [more ▼]

The present review deals with obesity in the dog, Definition, incidence, assessment, etiology and detrimental effects of obesity are firstly presented. In a second part, the treatment is discussed, with particular emphasis on the incorporation of large quantities of dietary fibres in low-energy specific purpose food. At present time, no conclusions can be drawn from published studies [less ▲]

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See detailCompte rendu de A. ANGENENDT, Heilige und Reliquien, Munich, 1994
George, Philippe ULg

in Francia. 1, Mittelalter (1997)

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See detailMultiple pregnancy-associated glycoproteins are secreted by day 100 sheep placenta
Xie, Sancai; Green, Jonathan; Bao, Bagna et al

in Biology of Reproduction (1997), 57(6), 1384-1393

Pregnancy-associated glycoprotein (PAG)-1 (PAG1) and pregnancy-specific protein B are either identical or closely related antigens released by trophoblast binucleate cells of placentas of cattle. Sheep ... [more ▼]

Pregnancy-associated glycoprotein (PAG)-1 (PAG1) and pregnancy-specific protein B are either identical or closely related antigens released by trophoblast binucleate cells of placentas of cattle. Sheep and other ruminants produce similar products. There is evidence, however, that these antigens, which are related structurally to the pepsinogens and other aspartic proteinases, are not single gene products but members of an extensive family. Here, the sequential use of ammonium sulfate precipitation and Sepharose blue, anion-exchange, and cation-exchange chromatographies, as well as isoelectric elution from a Mono P column, has allowed several PAG1-related molecules to be purified from the medium after culture of explants from Day 100 sheep placentas. Each of these PAGs cross-reacted to a varying extent with a panel of three different anti-PAG1 antisera. Four of them, all of which were major secretory products of the placenta, were subjected to amino-terminal microsequencing. Although each was related to ovine (ov) PAG1, none was identical. Reverse transcription-polymerase chain reaction was then used to amplify PAG1-related cDNA from Day 100 placental RNA. Seven novel full-length cDNA, all distinct from ovPAG1, were identified from 25 cDNA selected for sequencing. Only two of these (ovPAG3 and ovPAG7) encoded polypeptides identical in sequence at their inferred amino termini to one of the PAGs (ovPAG65) purified from explant cultures. Even so, they were only 84% identical in overall sequence. The remaining five cDNA were unique. In situ hybridization analysis revealed that expression of ovPAG3 and ovPAG7, like that of ovPAG1, is confined to trophoblast binucleate cells. The data confirm that at Day 100 of pregnancy the ovine placenta produces many different PAGs, which differ considerably in sequence and immunological cross-reactivity. [less ▲]

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See detailLes modes de transmission du virus de l'hépatite C
Delwaide, Jean ULg; Gerard, Christiane ULg; Sondag, Danièle ULg et al

in Revue Médicale de Liège (1997), 52(6), 388-391

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See detailFluidothérapie parentérale pratique chez les bovins
Rollin, Frédéric ULg

in Annales de Médecine Vétérinaire (1997), 141(2), 89-111

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte ... [more ▼]

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte disturbances and glycemia. The various classes of fluids are then considered as a function of the indications. Use of transfusion, hypertonic solutions and parenteral nutrition is broached. Routes and techniques of fluid administration are detailed. Obstacles encountered by the bovine practitioner when using parenteral fluid therapy are emphasized just as the means to overcome them. In this regard, it is described how to correctly prepare fluids for suited parenteral use in cattle. In fact, the present laws do not given this allowance to the practitioners. However, in most cases, it constitutes the only economical option avoiding worthless sufferings and death of the animal. [less ▲]

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See detailPeriodontal infections as potential risk factors for coronary heart diseases
Geerts, Sabine ULg; Legrand, Victor; Rompen, Eric ULg

in Journal of Clinical Periodontology (1997), 11

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See detailImplication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.
Gilles, Christine ULg; Polette, M.; Seiki, M. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1997), 76(5), 651-60

We have previously demonstrated that fibroblasts and invasive human breast carcinoma (HBC) cells specifically activate matrix metalloproteinase-2 (MMP-2) when cultured on 3-dimensional gels of type I ... [more ▼]

We have previously demonstrated that fibroblasts and invasive human breast carcinoma (HBC) cells specifically activate matrix metalloproteinase-2 (MMP-2) when cultured on 3-dimensional gels of type I collagen but not a range of other substrates. We show here the constitutive expression of membrane-type 1 (MT1)-MMP in both fibroblasts, and invasive HBC cell lines, that have fibroblastic attributes presumably acquired through an epithelial-to-mesenchymal transition (EMT). Treatment with collagen type I increased the steady-state MT1-MMP mRNA levels in these cells but did not induce either MT1-MMP expression or MMP-2 activation in noninvasive breast carcinoma cell lines, which retain epithelial features. Basal MT3-MMP mRNA expression had a pattern similar to that of MT1-MMP but was not up-regulated by collagen. MT4-MMP mRNA was seen in both invasive and noninvasive HBC cell lines and was also not collagen-regulated, and MT2-MMP mRNA was not detected in any of the HBC cell lines tested. These data support a role for MT1-MMP in the collagen-induced MMP-2-activation seen in these cells. In situ hybridization analysis of archival breast cancer specimens revealed a close parallel in expression of both collagen type I and MT1-MMP mRNA in peritumoral fibroblasts, which was correlated with aggressiveness of the lesion. Relatively high levels of expression of both mRNA species were seen in fibroblasts close to invasive tumor nests and, although only focally, in certain areas close to preinvasive tumors. These foci may represent hot spots for local degradation and invasive progression. Collectively, these results implicate MT1-MMP in collagen-stimulated MMP-2 activation and suggest that this mechanism may be employed in vivo by both tumor-associated fibroblasts and EMT-derived carcinoma cells to facilitate increased invasion and/or metastasis. [less ▲]

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See detailLe syndrome hépato-pulmonaire
Lamproye, Anne ULg; Weber, T.; Delwaide, Jean ULg et al

in Revue Médicale de Liège (1997), 52(10), 666-670

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See detailFibres alimentaires chez le chien II. Effets sur la vidange gastrique et le transit gastro-intestinal
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is ... [more ▼]

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is also given. The incorporation of fibres in the diet is one of many other factors which influence the mechanisms of emptying in the gastrointestinal tract. The effect of dietary fibres is also discussed in other monogastric species [less ▲]

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See detailInfluence du climat sur l'évolution de la population de tétras lyres Tetrao tetrix dans les Hautes-Fagnes de Belgique de 1967 à 1996
Loneux, Michèle ULg; Lindsey, James ULg; Ruwet, Jean-Claude

in Cahiers d'Ethologie (1997), 17(2-3-4), 345-386

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See detailBankfull discharge recurrence interval in gravel bed rivers
Petit, François ULg; Pauquet, A.

in Earth Surface Processes & Landforms (1997)

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Percentile (1997), 2

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See detailSpectroscopy of Ne IV in the wavelength Range 450–1100 Å
Bastin, Thierry ULg; Biémont, Emile ULg; Dumont, Paul-Dominique ULg et al

in Journal of the Optical Society of America. B, Optical Physics (1997), 14

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution ... [more ▼]

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution that was achieved, with a normal-incidence 2-m spectrometer, was sufficient to identify 53 new Ne IV lines and, consequently, to determine 18 new levels in the quartet and doublet systems and one sextet term. The energy values of 13 additional levels were also revised. The classification work was facilitated by the use of scaled relativistic Hartree–Fock calculations. [less ▲]

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See detailAutoregulation of endogenous glucose production in man.
Tappy, L.; Tounian, P.; Paquot, Nicolas ULg

in Biochemical Society Transactions (1997), 25(1), 11-3

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See detailThe faint young sun climatic paradox: Influence of the continental configuration and of the seasonal cycle on the climatic stability
Longdoz, Bernard; François, Louis ULg

in Global and Planetary Change (1997), 14(3-4), 97-112

A quasi-three-dimensional climate model is used to study the early state of the Earth when the solar luminosity was 70% of the present value, Usually, climatic simulations going back to this period lead ... [more ▼]

A quasi-three-dimensional climate model is used to study the early state of the Earth when the solar luminosity was 70% of the present value, Usually, climatic simulations going back to this period lead to a completely frozen planet contrasting with the geologic evidences of sedimentary rock formation and thus of the presence of liquid water at the surface of the continents during the Archean (4.6-2.5 billion years before present). Here, several model simulations are performed for solar luminosities varying between 0.7 and 1 times the present value. Using the present-day continental configuration and taking the seasonal cycle into account, a steady state is found in which glaciation is complete but snow covers only some oceanic coasts, leaving the continents essentially snow-free. As a result, the albedo of the continental area is strongly reduced compared to that of the frozen ocean, Some continental temperatures can almost reach the freezing point of water in summer (-1 degrees C in the center of Eurasia). This result can be explained by the behavior of the detailed hydrologic cycle included in the model. During the decrease of the solar luminosity, the jump to a completely frozen Earth occurs when the solar luminosity reaches 0.86 times its present value. The behavior of the climatic system is substantially different with a global ocean configuration. In the absence of land surfaces, the meridional heat transport, explicitly calculated, is less effective and the glaciation of a model latitude zone does not lead to the glaciation of its equatorward neighbor. The climate instability is relatively local and the jump to the completely frozen state is much more progressive than in the case of the modem continental configuration. The role of the seasonal cycle in the paleoclimatic simulation is also studied. Due to the non-linearity of the model, removing the seasonal cycle drives the system to an increase of the annual mean planetary albedo and to a decrease of the relative value (0.82) of the critical solar luminosity at which the jump to the completely frozen solution occurs. [less ▲]

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See detailPrognostic factors in urothelial renal pelvis and ureter tumors: A multicenter Rare Cancer Network study
Ozsahin, Mahmut; Zouhair, Abderrahim; Villà, S. et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 3(2(supp)), 290

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