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See detailMagnetic properties of Np2T2Sn compounds
Sanchez, Jean-Pierre; Colineau, E.; Jeandey, C. et al

in Physica B: Condensed Matter (1995), 206 & 207

The magnetic properties of the Np2T2Sn series investigated by 237Np Mössbauer spectroscopy are reported. Magnetic ordering is shown to occur for T --- Ni, Pd, Pt, whereas the Np ions do not carry a local ... [more ▼]

The magnetic properties of the Np2T2Sn series investigated by 237Np Mössbauer spectroscopy are reported. Magnetic ordering is shown to occur for T --- Ni, Pd, Pt, whereas the Np ions do not carry a local moment when T --- Co, Ru, Rh. Comparisons are made with the corresponding Np2T2In and U2T2Sn compounds. [less ▲]

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See detailElectronic properties of U2Ni2Sn
Kindo, Koichi; Fukushima, T.; Kumada, T. et al

in Journal of Magnetism & Magnetic Materials (1995), 140-144(2), 1369-1370

We report on the bulk electronic properties of U2Ni2Sn, which crystallizes in the tetragonal U3Si2 structure. Pronounced anomalies in the temperature dependencies of magnetic susceptibility, specific heat ... [more ▼]

We report on the bulk electronic properties of U2Ni2Sn, which crystallizes in the tetragonal U3Si2 structure. Pronounced anomalies in the temperature dependencies of magnetic susceptibility, specific heat and electrical resistivity indicate magnetic ordering below TN = 26 K. An antiferromagnetic ground state is corroborated by the occurrence of three metamagnetic transitions at about 30, 39 and 51 T in the field dependence of the magnetization. The lack of any saturation tendency in the highest field applied (57 T) may suggest further transition(s) to occur in even higher fields. [less ▲]

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See detailPeroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives
Liégeois, Jean-François ULg; Rogister, F.; Delarge, J. et al

in Archiv der Pharmazie (1995), 328(2), 109-12

According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation ... [more ▼]

According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics. [less ▲]

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See detailLe cas clinique du mois. A propos d'un cas de sécrétion ectopique d'ACTH
Biessaux, Yves ULg; Paquot, Nicolas ULg; Scheen, A. J. et al

in Revue Médicale de Liège (1995), 50(2), 55-6

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See detailAmpd, Essential for Both Beta-Lactamase Regulation and Cell Wall Recycling, Is a Novel Cytosolic N-Acetylmuramyl-L-Alanine Amidase
Jacobs, Christine ULg; Joris, Bernard ULg; Jamin, M. et al

in Molecular Microbiology (1995), 15(3), 553-9

In enterobacteria, the ampD gene encodes a cytosolic protein which acts as a negative regulator of beta-lactamase expression. It is shown here that the AmpD protein is a novel N-acetylmuramyl-L-alanine ... [more ▼]

In enterobacteria, the ampD gene encodes a cytosolic protein which acts as a negative regulator of beta-lactamase expression. It is shown here that the AmpD protein is a novel N-acetylmuramyl-L-alanine amidase (E.C.3.5.1.28) participating in the intracellular recycling of peptidoglycan fragments. Surprisingly, AmpD exhibits an exclusive specificity for substrates containing anhydro muramic acid. This anhydro bond is mainly found in the peptidoglycan degradation products formed by the periplasmic lytic transglycosylases and thus might behave as a 'recycling tag' allowing the enzyme to distinguish these fragments from the newly synthesized peptidoglycan precursors. The AmpD substrate (or substrates) which accumulates in the absence of the corresponding enzymatic activity acts as an intracellular positive effector for beta-lactamase expression and might represent an element of a communication network between the chromosome and the cell wall peptidoglycan. [less ▲]

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See detailMacrofagos e factor a de necrose tumoral na necrolise epidermica toxica
Paquet, Philippe ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Arquivos de Dermatologia (1995), 2

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular ... [more ▼]

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular inflamatorio varió dependiendo del estado de la enfermedad. La principal característica constante fue la importante implicación de la línea monocito-macrófago, incluyendo dendrocitos factor XIIIa+ HLA-DR+ y macrófagos CD68+ Mac 387+, antes y durante la necrosis epidérmica. El número de linfocitos CD4+ y CD8+ era comparativamente reducido. Ello se asociaba con un denso marcaje para el factor de necrosis tumoral alfa en la epidermis. CONCLUSIONES: Las células de estirpe monocito-macrófago superan en nùmero ampliamente a los linfocitos en las lesiones de la necrólisis epidérmica tóxica. El factor de necrosis tumoral alfa es problablemente una de las citocinas principales responsables de la necrosis. [less ▲]

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See detailMagnetic kinetic growth-models
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg; Cloots, Rudi ULg

in Journal of Magnetism & Magnetic Materials (1995), 140(Part 3), 2185-2186

Magnetic kinetic growth models are kinetic growth model(s), like the Eden or the DLA models, but allow for the growth to have an extra degree of freedom (a 'spin') which can be coupled to an external ... [more ▼]

Magnetic kinetic growth models are kinetic growth model(s), like the Eden or the DLA models, but allow for the growth to have an extra degree of freedom (a 'spin') which can be coupled to an external field. Two-dimensional simulations show interesting morphologies and parameter dependences. [less ▲]

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See detailThe role of agrometeorological data bases and software in agrometeorological training in developing countries.
Tychon, Bernard ULg; Tonnard, Victor

in FAO Agrometeorology series (1995), 13

The paper covers a Belgian agrometeorological training course intended for francophone students from developing countries who have completed a minimum of four years training in agrometeorology. Today ... [more ▼]

The paper covers a Belgian agrometeorological training course intended for francophone students from developing countries who have completed a minimum of four years training in agrometeorology. Today, many of our students are heads of agrometeorological departments and divisions. THey are interested in everything that could promote agrometeorological methods to preserve food security and the natural resources of their country. During the past few years, the students have been trained in using microcomputers and solving simple agro-meteorological problems as part of the course. The results obtained so far can now be evaluated, since the microcomputer training began a few years ago; some comments on the future development of this approach are presented. [less ▲]

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See detailSimulated growth and microstructure of DyBa2Cu3O7-X with and without Dy2BaCUO5 addition
Vandewalle, Nicolas ULg; Cloots, Rudi ULg; Ausloos, Marcel ULg

in Journal of Materials Research (1995), 10(2), 268-273

We present optical observations of magnetically melt-textured DyBa2Cu307-x with and without 20 wt. % excess of Dy2BaCu05. From these observations, we propose some kinetic mechanism of the growth of 123 ... [more ▼]

We present optical observations of magnetically melt-textured DyBa2Cu307-x with and without 20 wt. % excess of Dy2BaCu05. From these observations, we propose some kinetic mechanism of the growth of 123 compounds. Kinetic processes can simulated on computers. Two (very) simple models derived from the well-known Eden model are presented. They simulate the growth of the grain front. The simulated patterns agree with the observations. The microstructure of such materials cannot be explained by thermodynamic and chemical considerations alone, but explanations must include the kinetics of the growth front as well. From our observations, we conclude that the growth probability ratios g(110)/g(100)/g(001) are of the order of 10 and 50, respectively. [less ▲]

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See detailComment j'explore un patient hypertendu
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1995), 50(2), 91-92

Des examens complémentaires consitituent une étape importante de la prise en charge d'un patient hypertendu. Du bilan de base simple, peu coûteux et à appliquer à tous, aux examens paracliniques les plus ... [more ▼]

Des examens complémentaires consitituent une étape importante de la prise en charge d'un patient hypertendu. Du bilan de base simple, peu coûteux et à appliquer à tous, aux examens paracliniques les plus sophistiqués, la prescription nécessite cependant une personnalisation. II n'y a en effet pas une hypertension à explorer, mais des hypertendus, fort différents entre eux. Les examens à recommander vont cerner l'état actuel cardiaque, artériel et rénal ainsi que le profil de risque cardiovasculaire. Ils vont aussi rechercher une cause à l'élévation de pression si la clinique, l'anamnèse et quelques examens de laboratoire le suggèrent. [less ▲]

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See detailSpecificity and Sensitivity of Temporalis Es2 Measurements in the Diagnosis of Chronic Primary Headaches
Wang, W.; De Pasqua, Victor ULg; Gérard, P. et al

in Headache (1995), 35(2), 85-8

We have evaluated the specificity and sensitivity of temporalis ES2 measurements for the diagnosis of primary headaches. Ninety-four outpatients diagnosed according to IHS criteria were prospectively ... [more ▼]

We have evaluated the specificity and sensitivity of temporalis ES2 measurements for the diagnosis of primary headaches. Ninety-four outpatients diagnosed according to IHS criteria were prospectively included: 25 had chronic tension-type headache (code 2.2.), 15 episodic tension-type headache (code 2.1.), 20 migraine without aura (code 1.1.) and 34 chronic daily headaches with daily analgesics/ergotamine abuse (code 8.2.). In chronic tension-type, the sensitivity of the ES2 test was 84% at the 0.1 and the 0.5 Hz, but only 56% at the 2Hz stimulation rates. Its specificity was 100% at 0.1Hz, 90% at 0.5Hz and 95% at 2Hz compared to migraine; positive predictive values were at similar levels. Sensitivity of ES2 at 0.1 Hz was 67% in episodic tension-type headache, but its positive predictive value versus migraine was excellent. Comparing chronic tension-type headache and analgesic abusers, the specificity and positive predictive value of the ES2 test for diagnosing chronic tension-type headache were less satisfactory (60%) while the negative predictive values, however, remained good (83% at 0.1Hz). The results confirm that the temporalis ES2 test has a higher diagnostic sensitivity in chronic and episodic tension-type headache, but that it has a high negative predictive value for both types of tension-type headache compared to other primary headaches. For diagnostic purposes, the 0.1Hz stimulation rate seems optimal. The 2Hz stimulation rate is the least sensitive, although it may induce total disappearance of ES2 in up to 40% of patients. ES2 is of limited usefulness for separating chronic tension-type headache and chronic drug-abuse headache, possibly because the latter group comprises both tension-type headache and migraine patients. [less ▲]

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See detailMagnetism in U2T2X compounds
Havela, Ladislav; Sechovsky, Vladimir; Svoboda, P. et al

in Journal of Magnetism & Magnetic Materials (1995), 140-144(2), 1367-1368

Magnetic and other electronic properties are presented for the U2T2X compounds (T = late transition metal, X = Sn or In), that crystallize in the tetragonal U3Si2-type structure. They show the formation ... [more ▼]

Magnetic and other electronic properties are presented for the U2T2X compounds (T = late transition metal, X = Sn or In), that crystallize in the tetragonal U3Si2-type structure. They show the formation of 5f magnetic moments and antiferromagnetic ordering in compounds where weak 5f-d hybridization is expected. Near the onset of magnetic ordering strongly enhanced γ-values are found. Neutron-diffraction experiments on U2Pd2Sn and U2Pd2In point to a connection between the mutual coordination of U atoms and the type of magnetic anisotropy [less ▲]

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See detailContribution of Mutant Analysis to the Understanding of Enzyme Catalysis: The Case of Class a Beta-Lactamases
Matagne, André ULg; Frère, Jean-Marie ULg

in Biochimica et Biophysica Acta (1995), 1246(2), 109-27

Class A beta-lactamases represent a family of well studied enzymes. They are responsible for many antibiotic resistance phenomena and thus for numerous failures in clinical chemotherapy. Despite the facts ... [more ▼]

Class A beta-lactamases represent a family of well studied enzymes. They are responsible for many antibiotic resistance phenomena and thus for numerous failures in clinical chemotherapy. Despite the facts that five structures are known at high resolution and that detailed analyses of enzymes modified by site-directed mutagenesis have been performed, their exact catalytic mechanism remains controversial. This review attempts to summarize and to discuss the many available data. [less ▲]

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See detailSimulation of Human B-Lymphocyte Proliferation by Agm-1470, a Potent Inhibitor of Angiogenesis
Antoine, Nadine ULg; Bours, Vincent ULg; Heinen, Ernst ULg et al

in Journal of the National Cancer Institute (1995), 87(2), 136-9

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See detailLes infections cutanées dues à l'herpès
Nikkels, Arjen ULg

in Actualités Médicales Belges (1995), 8(450),

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See detailSynthesis and Processing of Bovine Herpesvirus-1 Glycoprotein H
Baranowski, Eric; Dubuisson, Jean; van Drunen Little-van den Hurk, Sylvia et al

in Virology (1995), 206(1), 651-4

The translation product of the bovine herpesvirus-1 (BHV-1) gH gene was identified and characterized. Synthetic peptides were used to generate specific antisera and a glycoprotein of 108K was precipitated ... [more ▼]

The translation product of the bovine herpesvirus-1 (BHV-1) gH gene was identified and characterized. Synthetic peptides were used to generate specific antisera and a glycoprotein of 108K was precipitated by one of the antisera. Cross-immunoprecipitations with monoclonal antibodies to BHV-1 glycoprotein gp108 and the anti-gH peptide antiserum demonstrated that gp108 is the translation product of the gH open reading frame. Glycoprotein gH synthesis and intracellular processing was analyzed in infected Madin-Darby bovine kidney cells using anti-gp 108 monoclonal antibodies. Glycoprotein gH is expressed as a beta-gamma protein and could be detected by radioimmunoprecipitation as early as 2 hr postinfection. Cotranslational N-glycosylation of gH is essential for the recognition by monoclonal antibodies, suggesting that N-linked glycans are involved in protein folding or that they are targets for most of monoclonal antibodies used in this study. [less ▲]

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See detailKinetic Study of Interaction between Brl 42715, Beta-Lactamases, and D-Alanyl-D-Alanine Peptidases
Matagne, André ULg; Ledent, Philippe; Monnaie, Didier et al

in Antimicrobial Agents and Chemotherapy (1995), 39(1), 227-31

A detailed kinetic study of the interactions between BRL 42715, a beta-lactamase-inhibiting penem, and various beta-lactamases (EC 3.5.2.6) and D-alanyl-D-alanine peptidases (DD-peptidases, EC 3.4.16.4 ... [more ▼]

A detailed kinetic study of the interactions between BRL 42715, a beta-lactamase-inhibiting penem, and various beta-lactamases (EC 3.5.2.6) and D-alanyl-D-alanine peptidases (DD-peptidases, EC 3.4.16.4) is presented. The compound was a very efficient inactivator of all active-site serine beta-lactamases but was hydrolyzed by the class B, Zn(2+)-containing enzymes, with very different kcat values. Inactivation of the Streptomyces sp. strain R61 extracellular DD-peptidase was not observed, and the Actinomadura sp. strain R39 DD-peptidase exhibited a low level of sensitivity to the compound. [less ▲]

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See detailBasic Research and Policy Making for the Development of Vessel Traffic Management Information Systems
Marchal, Jean ULg

in Basic Research and Policy Making (1995)

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See detailIncreased Expression of Osteonectin and Osteopontin, Two Bone Matrix Proteins, in Human Breast Cancer
Bellahcene, Akeila ULg; Castronovo, Vincenzo ULg

in American Journal of Pathology (1995), 146(1), 95-100

Microcalcifications are a common phenomenon associated with breast cancer and are often the only mammographic sign of a malignant breast disease. Although microcalcifications are not restricted to breast ... [more ▼]

Microcalcifications are a common phenomenon associated with breast cancer and are often the only mammographic sign of a malignant breast disease. Although microcalcifications are not restricted to breast cancer and can be also associated with benign lesions, it is noteworthy that they are composed exclusively of hydroxyapatite in breast carcinoma. Hydroxyapatite is the bone-associated phosphocalcic crystal the deposition of which in bone tissue requires the coordinated expression of several molecules such as osteonectin (OSN) and osteopontin (OPN), synthesized by cells of the osteoblastic lineage. In this study, we evaluated the expression of these two bone matrix proteins, using an immunoperoxidase technique and specific antibodies, in 79 breast lesions including 28 benign and 51 cancerous specimens. We found that normal mammary tissue associated with the lesions examined expressed generally undetectable or lightly detectable (0 or 1+) amounts of OSN and OPN (92 and 81%, respectively). Benign breast lesions, including fibroadenoma and fibrocystic dysplasia, were generally weakly stained (0 or 1+) with both anti-OSN and anti-OPN antibodies (96.4 and 60.7%, respectively). Interestingly, the majority of both in situ and invasive breast carcinoma lesions showed a strong expression (2+ or 3+) for OSN or OPN (74.5 and 84.3%, respectively). High expression of these two bone matrix proteins was associated with frequent microcalcification deposition in the lesion. This study is the first extensive study of OSN and OPN expression in mammary cancers. Our data suggest that OSN and OPN could play a role in the formation of ectopic microcalcifications often associated with breast cancer. It is also tempting to speculate that the expression of these two glycoproteins by breast cancer cells play a role in the preferred bone homing of breast metastases. [less ▲]

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See detailMagnetic diffusion-limited aggregation
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 51(1), 597-603

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See detailA Prenatal Trisomy 21 Screening Program Using Alpha-Fetoprotein, Human Chorionic Gonadotropin, and Free Estriol Assays on Maternal Dried Blood
Verloes, Alain ULg; Schoos, Roland ULg; Herens, Christian ULg et al

in American Journal of Obstetrics and Gynecology (1995), 172(1, Pt 1), 167-74

OBJECTIVE: The feasibility of large-scale Down syndrome maternal screening with dried blood samples and nonradioactive methods was examined. STUDY DESIGN: A prospective observation study was performed on ... [more ▼]

OBJECTIVE: The feasibility of large-scale Down syndrome maternal screening with dried blood samples and nonradioactive methods was examined. STUDY DESIGN: A prospective observation study was performed on a nonselected population of 11,241 pregnant women sampled between January 1991 and September 1992, between 14 and 24 weeks' gestation (ultrasonographic scanning available for 91.6%), through a multicenter collaborative network. Enzyme-linked immunosorbent assays for alpha-fetoprotein, human chorionic gonadotropin, and free estriol were performed on dried blood samples. Risk determination was made with an in-house software implementing the multivariate gaussian log likelihood method. RESULTS: A total of 10,450 samples were eligible for the study. Mean age at term was 27.9 years. A total of 6.84% of the patients were > or = 35 years old with a prior risk of trisomy 21 > 1:350. The general positive rate of our sample was 8.15%. After calculation 31.7% with prior risk > 1:350 were still in the high-risk group; 6.36% of the low-risk group were found to be at high risk for Down syndrome. Fifteen trisomic pregnancies were observed, of which 11 had a calculated risk higher than the selected cutoff value (1:350). The overall detection rate was 73%, specificity was 92%, and positive predictive power was 1.2%. CONCLUSION: Our pilot study has shown performances within the range of conventional serum screening programs. Dried blood assays are a handy alternative to serum assays. Blot paper cards represent a simple method of sampling, well fitted for large population screening. Combined with nonradioactive methods, this method appears to be both low cost and effective. The current work apparently is the first large-scale Down screening program performed with dried blood. [less ▲]

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See detailLe romancier en projet. Quand André Gide étudiait Georges Simenon
Denis, Benoît ULg

in Bulletin des amis d'André Gide (1995), XXVIII(105), 53-70

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See detailTamoxifen and its active metabolite inhibit growth of estrogen receptor-negative MDA-MB-435 cells
Charlier, Corinne ULg; Chariot, Alain ULg; Antoine, Nadine ULg et al

in Biochemical Pharmacology (1995), 49

Tamoxifen (TAM), the non-steroidal anti-estrogen most widely administered to breast cancer patients, acts, at least in part, by competing with estrogen receptors (ER). However, the existence of an ... [more ▼]

Tamoxifen (TAM), the non-steroidal anti-estrogen most widely administered to breast cancer patients, acts, at least in part, by competing with estrogen receptors (ER). However, the existence of an alternative mechanism of action for this drug is supported by the clinical observations that: (a) 30% of patients with ER-negative cancer cells respond to TAM, and (b) 30% of patients with ER-positive cancer cells are not sensitive to this anti-estrogen. In this study, we observed that growth of the human ER-negative breast cancer cell line MDA-MB-435 was inhibited by TAM and 4-hydroxytamoxifen (4OH-TAM) in a concentration-dependent fashion. Both monoclonal enzymoimmunoassay and Dextran Charcoal Coated Scatchard radioimmunoassay analysis demonstrated that this MDA-MB-435 cell line does not express ER. The absence of ER in MDA-MB-435 cells was also demonstrated at the mRNA level by both northern blot hybridization and reverse transcription-polymerase chain reaction techniques. MDA-MB-435 cell proliferation was not affected by 17 beta-estradiol or by the pure anti-estrogen ICI 164384, further demonstrating that the observed effects of TAM and its active metabolite on the proliferation of MDA-MB-435 cells were due to an ER-independent mechanism, yet to be identified. MDA-MB-435 thus appears to be a promising original model for the study of the alternative ER-independent mechanisms of action of TAM. [less ▲]

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See detailInvestigation of the Relationship between Osteoporosis and the Collagenase Gene by Means of Polymorphism of the 5'upstream Region of This Gene
Thiry-Blaise, L. M.; Taquet, A. N.; Reginster, Jean-Yves ULg et al

in Calcified Tissue International (1995), 56

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we ... [more ▼]

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we investigated a possible relationship between the collagenase gene and osteoporosis. Analysis of an amplified genomic DNA fragment from -524 to +52 by denaturing gradient gel electrophoresis and sequencing allowed us to detect three dimorphic sites upstream of base -300, one of them leading to a BanI restriction site. None of the sites could be directly associated with osteoporosis. The allele frequencies of the three dimorphic sites were estimated. The interallelic ratios were high, thus providing new useful genetic markers for linkage analysis. When comparing these ratios in osteoporotic and nonosteoporotic subjects, no significant differences could be observed. [less ▲]

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See detailPropagations en réseaux de cours d'eau d'ondes de crues incluant des ressauts
Pirotton, Michel ULg

in Tribune de l'Eau (La) (1995), 49(574), 23-33

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See detailAcquis de la recherche en matière d'évaluation génétique des ovins et des caprins en Tunisie
D'Jemali, M'naouer; Jamal, Sofiene; Ben-Dhiaf, Sonia et al

in Cahiers Options Méditerranéennes (1995), 11

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 ... [more ▼]

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 flocks of Barbary sheep in 1987-92 are presented in 14 tables and discussed. [less ▲]

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See detailPolitics in the lifeboat. Immigrants and the American Democratic Order de J.C. Harles
Martiniello, Marco ULg

in International Migration Review (1995), 28(108), 900-901

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See detailFra Stein til Waldrop: sprogdigtningen og de nye prosadigtere
Delville, Michel ULg; Schatz-Jakobsen, Claus

in Den Blå Port: Tidsskrift for Litteratur (1995)

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See detail"De l'exequatur et des causes de préférence"
Moreau, Pierre ULg

in Actualités du Droit (1995), (2), 395-410

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See detailNetherton’s syndrome in two sisters. A ten year experience of therapy with retinoids
Groves, S.; Dezfoulian, Bita ULg; Bonardeaux, Ch et al

in Journal of the European Academy of Dermatology & Venereology (1995)

Netherton’s syndrome is a recessive autosomal disease associating ichthyosiform dermatosis, hair dysplasia and systemic involvement. (Netherton, 1958, Arch. Dermatol., Vol. 78,483-487). We report the ... [more ▼]

Netherton’s syndrome is a recessive autosomal disease associating ichthyosiform dermatosis, hair dysplasia and systemic involvement. (Netherton, 1958, Arch. Dermatol., Vol. 78,483-487). We report the observation of two sisters who present the complete form of Netherton’s syndrome. Both patients were treated with retinoids for more than ten years. [less ▲]

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See detailCellular and molecular aspects of thymic T-cell education to neurohypophysial peptides
Geenen, Vincent ULg; Martens, Henri ULg; Vandersmissen, Eric et al

in Excerpta Medica (1995), 1098

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See detailEvaluation bryologique d'un projet de réinondation par les crues du Rhin: l'exemple de la réserve naturelle d'Erstein (Alsace, France)
Vanderpoorten, Alain ULg; Klein, J. P.; De Zuttere, P.

in Belgian Journal of Botany (1995), 128

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See detailLas palabras póstumas de Albert Camus
Ardissone, Diana; Willson, Patricia ULg

in Espacios de crítica y producción (1995), (16), 63-64

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See detailThe dexamethasone suppression test in violent suicide attempters with major depression.
Pitchot, William ULg; Hansenne, Michel ULg; Gonzalez Moreno, A. et al

in Biological Psychiatry (1995), 37(4), 273-4

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See detailPulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1995), 42(8), 531-544

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in ... [more ▼]

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies. [less ▲]

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See detailprésentation de Abbé Lhomond, De viris (les grands hommes de Rome), Latin/français, traduit et présenté par J. Gaillard, Paris, 1995
Rochette, Bruno ULg

in Bulletin de la Fédération des Professeurs de Grec et de Latin [=FPGL] (1995), 99

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See detailTreatment of patent ductus arteriosus by placement of intravascular coils in a pup
Snaps, Frédéric ULg; Mc Entee, Kathleen ULg; Saunders, J. et al

in Journal of the American Veterinary Medical Association [=JAVMA] (1995), 6(6), 724-725

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a ... [more ▼]

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a large aortic base was outlined. A second selective angiographic procedure was performed to functionally close the PDA by use of thrombotic coils; complete obstruction was obtained. Twenty-four hours after the procedure, the murmur disappeared. One month later, the dog was reexamined and found to be clinically normal. [less ▲]

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See detailLocalization of varicella-zoster virus nucleic acids and proteins in human skin.
Nikkels, Arjen ULg; Debrus, S.; Sadzot-Delvaux, Catherine ULg et al

in Neurology (1995), 45(12 Suppl 8), 47-9

The pathogenic mechanisms involved in varicella-zoster virus (VZV) infections remain elusive. The pattern of cutaneous distribution of the IE63 protein and of the gpI (gE) and gpII glycoproteins with ... [more ▼]

The pathogenic mechanisms involved in varicella-zoster virus (VZV) infections remain elusive. The pattern of cutaneous distribution of the IE63 protein and of the gpI (gE) and gpII glycoproteins with their corresponding genome sequences during VZV infections was studied by immunohistochemistry and in situ hybridization. Skin biopsy specimens were obtained from immunocompetent and immunocompromised patients with varicella, herpes zoster, or atypical VZV lesions. The first evidence for VZV infection consisted of the presence of IE63 in keratinocytes. In the vesicles and pustules, the viral transcripts gpI, gpII, and IE63 and the corresponding nucleic acids for gpI and gpII were identified in keratinocytes, sebocytes, Langerhans cells, dermal dendrocytes, monocytes/macrophages, and endothelial cells. The gpI and gpII glycorpoteins were essentially located on the cellular membranes while IE63 expression was generally restricted to the nuclei. In three biopsies of early herpes zoster, viral proteins were disclosed in dermal nerves and in perineurial type I dendrocytes. This was never encountered in varicella. Vasculitic changes and endothelial cell involvement were more prominent in varicella than in herpes zoster. It is concluded that the secondary viremia in varicella that affects the dermal endothelial cells is followed by a cell-to-cell spread to keratinocytes. In herpes zoster, the viral progression through cutaneous nerves primarily extends to the pilosebaceous units with a secondary involvement of epidermal keratinocytes, followed by a further spread to dermal cells. [less ▲]

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See detailIndice plasmodique et parasitémie à Plasmodium falciparum: valeur diagnostique et pronostique au Congo.
Carme, B.; Hayette, Marie-Pierre ULg; Mbitsi, A. et al

in Annales de la Société Belge de Médecine Tropicale (1972) (1995), 75

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the ... [more ▼]

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the intention of establishing diagnosis and prognosis value of Plasmodium falciparum parasitaemia in areas with high perennial transmission. In such an area Congolese school children (6-10 years old) had 88% P. falciparum index, this is the same percentage as that for children hospitalized with a pernicious attack. However, the parasite load is distributed differently; parasitaemia is greater than 6,000 asexual form for P. falciparum (af/Pf/µl) in only 4,6% of cases in the former group, versus 67% in the second group. A threshold of 10,000 af/Pf/µl above which the Plasmodium infection triggers a febrile attack in semi-immune children, is confirmed in school children in a rural context where the factor of taking antimalarial drugs within the preceding days is negligible: three out of four children with levels above this threshold are febrile versus 4,1% (7 out of 170) with lower blood parasite levels. Some adults where also asymptomatic carriers but much less frequently and with lower mean parasitaemia levels. The parasite load mirrors the clinical severity although this concept can be misleading as an individual prognostic criterion and foor hospital studies carried out in areas where multiple drug administration before hospitalization is common. For the studies recently performed in Brazzaville, the 5% threshold of parasitized red cells, the WHO severity criterion was never reached in asymptomatic subject or in cases of simple attack; it was reached in one out of two cases of pernicious attack. [less ▲]

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See detailThe effect of gonadal development and sex steroids on growth hormone secretion in the male tilapia hybrid (Oreochromis niloticus x O. aureus O;
Melamed, P.; Eliahu, N.; Ofir, M. et al

in Fish Physiology and Biochemistry (1995)

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See detailReaction Window in the single-electron capture by Ammonia Dications.
Leyh, Bernard ULg; Hoxha, Antuan

in Chemical Physics (1995), 192

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC ... [more ▼]

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC cross-section goes through a maximum within a reaction window centered at an exothermicity of approximately 4.5 eV. This corresponds to a target-projectile distance for the charge transfer of about 3.2 Angstöm. The average internal energy of NH3+-ions resulting from SEC has been obtained both via translational energy gain measurements and via an analysis of the daughter ion spectra. The agreement between both methods is satisfactory and shows that the lower the ionisation energy of the target, the more probable the excitation of NH3+ to the A2E state. With benzene (ionization energy=9.25 eV) as the target gas, however, the excess energy is converted partly to internal energy of C6H6+, leading most probably to the D2B2u, E2B1u and F2A1g states of C6H6+. A model based on the Landau-Zener non-adiabatic formalism, including one entrance channel (NH32++G) and two exit channels (NH3+ X2A"2+G+ and NH3+ A2E+G+) accounts qualitatively for the observed results in the case of exothermic single-electron capture. This model is not appropriate for slightly exothermic and endothermic charge transfer, i.e., in the present case, for the Ne and He target gases. [less ▲]

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See detailCatecholaminergic function and P300 amplitude in major depressive disorder (P300 and catecholamines).
Hansenne, Michel ULg; Pitchot, William ULg; Gonzalez Moreno, Antonio et al

in Electroencephalography and Clinical Neurophysiology (1995), 96(2), 194-6

The neurobiology of P300 is still a subject of controversy. P300 amplitude appears to be modulated by multiple neurotransmitter systems, especially dopaminergic, noradrenergic as well as cholinergic and ... [more ▼]

The neurobiology of P300 is still a subject of controversy. P300 amplitude appears to be modulated by multiple neurotransmitter systems, especially dopaminergic, noradrenergic as well as cholinergic and GABAergic. In this study, we investigated the relationship between P300 amplitude and catecholaminergic neurotransmission as assessed by the growth hormone (GH) response to clonidine and apomorphine challenges in 20 major depressive patients. Results showed a correlation of P300 amplitude with the apomorphine test (r = 0.54; P = 0.01), but not with the clonidine test (r = 0.22; NS). This study supports a role for dopamine in the neurobiological modulation of P300 amplitude. [less ▲]

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See detailConformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Research Communications In Molecular Pathology and Pharmacology (1995), 90(1), 153-64

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation ... [more ▼]

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation of the molecular hydrophobicity potential. The calcium complexes formed with KAD-1229, A-4166, repaglinide or its enantiomer, displayed favourable attributes to act as ionophores. Such was not the case for the poorly efficient insulinotropic agent meglitinide and the biologically inactive enantiomer of A-4166. The configuration of the calcium complex formed with S 3075 also failed to display the features required for a high ionophoretic capacity. [less ▲]

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See detailPersonal name anomia: A single case study
Fery, P.; Vincent, Eric ULg; Brédart, Serge ULg

in Cortex (1995), 31

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See detailComment explorer la sensibilite a l'insuline chez l'homme?
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in Annales d'Endocrinologie (1995), 56(5), 523-30

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose ... [more ▼]

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose clamp is the reference method, well validated and easy to interpret, which allows various extensions to the basic experimental procedure in order to obtain more valuable information on the specific effects of insulin on the various aspects of glucose metabolism. However, it is time-consuming and labour-intensive. In contrast, the intravenous glucose tolerance test is easier to perform, but its interpretation is much more difficult and requires a modeling approach called the "minimal model". If the intravenous glucose tolerance test probably represents a good screening test, mainly on a population basis, the glucose clamp still remains the gold standard method to study insulin sensitivity in man. [less ▲]

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See detailSIMULTANEOUS OBSERVATIONS OF THE SATURNIAN AURORA AND POLAR HAZE WITH THE HST/FOC
Gérard, Jean-Claude ULg; DOLS, V.; Grodent, Denis ULg et al

in Geophysical Research Letters (1995), 22(20), 2685-2688

Near simultaneous observations of the Saturnian H-2 north ultraviolet aurora and the polar haze were made at 153 nm and 210 nm respectively with the Faint Object Camera on board the post-COSTAR Hubble ... [more ▼]

Near simultaneous observations of the Saturnian H-2 north ultraviolet aurora and the polar haze were made at 153 nm and 210 nm respectively with the Faint Object Camera on board the post-COSTAR Hubble Space Telescope. The auroral observations cover a complete rotation of the planet and, when co-added, they reveal the presence of an auroral emission near 80 degrees N with a brightness of about 150 kR of total H-2 emission. The maximum vertical optical depth at 210 nm is found to be located similar to 5 degrees equatorward of the auroral emission zone. The haze particles are presumably formed by hydrocarbon aerosols initiated by H-2(+) auroral production. In this case, the 3 x 10(10) W of H-2 emission observed with the FOG, combined with the deduced haze optical depth requires an efficiency of aerosol formation of about 7%. This result indicates that auroral production of hydrocarbon aerosols is a viable source of high-latitude haze. [less ▲]

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See detailFactors regulating megakaryocyte progenitor commitment to polyploidization.
Paulus, Jean-Michel ULg; Grosdent, J C; Prenant, M et al

in Comptes Rendus de l'Académie des Sciences. Série III. Sciences de la Vie (1995), 318(3), 381-6

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms ... [more ▼]

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms of megakaryocytes determined by microphotometric or flow cytometric measurements of megakaryocyte DNA have generally been used. However these techniques provide no information on the rate of commitment of CFU-MKC to polyploidy. Using a technique of clonal analysis determining the distributions of the number of doublings (NbD) undergone by CFU-MKC before committing to polyploidization, the polyploidization probability of CFU-MKC could be derived. This probability was found to be a constant independent from CFU-MKC mitotic history, since NbD distributions are exponential functions characterized by a constant rate of decay per doubling. By studying the effects of growth factors on polyploidization probability, it was also shown that: (1) this parameter is negatively regulated by growth factors contained in poke-weed or WEHI conditioned media, as well as by erythropoietin; (2) commitment to polyploidization does not require prior CFU-MKC division; (3) bipotent erythroid-megakaryocyte progenitors have a lower polyploidization probability than CFU-MKC; (4) determination of polyploidization probability reflects the activity of growth factors with greater accuracy than megakaryocyte colony count. [less ▲]

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See detailLa grande illusion (le photojournalisme: quelques repères)
Mélon, Marc-Emmanuel ULg

in Admiranda : Cahiers d'Analyse Filmique de l'Université de Provence (1995), 10

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See detailAntihyperglycaemic agents. Drug interactions of clinical importance.
Scheen, André ULg; Lefebvre, Pierre ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (1995), 12(1), 32-45

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias ... [more ▼]

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias, coronary insufficiency, heart failure and arthropathies. Thus, polymedication is the rule in this population, and the risk of drug interactions is important, particularly in elderly patients. The present review is restricted to the interactions of other drugs with antihyperglycaemic compounds, and will not consider the mirror image, i.e. the interactions of antihyperglycaemic agents with other drugs. Oral antihyperglycaemic agents include sulphonylureas, biguanides--essentially metformin since the withdrawn of phenformin and buformin--and alpha-glucosidase inhibitors, acarbose being the only representative on the market. These drugs can be used alone or in combination to obtain better metabolic control, sometimes with insulin. Drug interactions with antihyperglycaemic agents can be divided into pharmacokinetic and pharmacodynamic interactions. Most pharmacokinetic studies concern sulphonylureas, whose action may be enhanced by numerous other drugs, thus increasing the risk of hypoglycaemia. Such an effect may result essentially from protein binding displacement, inhibition of hepatic metabolism and reduction of renal clearance. Reduction of the hypoglycaemic activity of sulphonylureas due to pharmacokinetic interactions with other drugs appears to be much less frequent. Drug interactions leading to an increase in plasma metformin concentrations, mainly by reducing the renal excretion or the hepatic metabolism of the biguanide, should be avoided to limit the risk of hyperlactaemia. Owing to its mode of action, pharmacokinetic interferences with acarbose are limited to the gastrointestinal tract, but have not been extensively studied yet. Pharmacodynamic interactions are quite numerous and may result in a potentiation of the hypoglycaemic action or, conversely, in a deterioration of blood glucose control. Such interactions may be observed whatever the type of antidiabetic treatment. They result from the intrinsic properties of the coprescribed drug on insulin secretion and action, or on a key step of carbohydrate metabolism. Finally, a combination of 2 to 3 antihyperglycaemic agents is common for treating patients with NIDDM to benefit from the synergistic effect of compounds acting on different sites of carbohydrate metabolism. Possible pharmacokinetic interactions between alpha-glucosidase inhibitors and classical antidiabetic oral agents should be better studied in the diabetic population. [less ▲]

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See detailGrowth hormone response to clonidine in nondepressed patients with a history of suicide attempts.
Pitchot, William ULg; Hansenne, Michel ULg; Moreno, A. G. et al

in Biological Psychiatry (1995), 38(3), 201-3

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See detailLes aliments industriels chez le chien: caractéristiques et utilisation dans différents états physiologiques
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1995), 139(5), 309-316

Commercial dog food is more and more frequently used as sole diet. The present review characterizes the different types of commercial diets. Principles of bioenergetic allow the calculation of energy ... [more ▼]

Commercial dog food is more and more frequently used as sole diet. The present review characterizes the different types of commercial diets. Principles of bioenergetic allow the calculation of energy density using a prediction equation. Energy requirements are also calculated. Practical use of industrial dog food are illustrated for growing pups, dogs at maintenance or in reproduction. [less ▲]

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See detailDevelopmental disturbance of access to biographical information and people's names: A single-case study
Van der Linden, Martial ULg; Brédart, Serge ULg; Schweich, M.

in Journal of the International Neuropsychological Society (1995), 1(6), 589-595

The paper describes the case of a person (GB) without any clinical evidence of cerebral disease who showed a specific impairment in the retrieval of biographical information, including names, about famous ... [more ▼]

The paper describes the case of a person (GB) without any clinical evidence of cerebral disease who showed a specific impairment in the retrieval of biographical information, including names, about famous people. This deficit appeared while GB scored normally in different long-term memory tasks, and in object naming tasks. Moreover, he showed no impairment in the structural encoding and the recognition of faces. His specific impairment is interpreted both in terms of Bruce and Young's (1986) functional model of person recognition and in terms of the more recent Burton et al. (1990) interactive activation version of the Bruce and Young model. [less ▲]

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See detailPostgastroplasty recovery of ideal body weight normalizes glucose and insulin metabolism in obese women.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(2), 364-9

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months ... [more ▼]

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months after successful gastroplasty (BMI, 23.7 +/- 0.6 kg/m2) in eight obese women and, for comparison, in eight age- and weight-matched nonobese control women (BMI, 23.6 +/- 0.7 kg/m2). All subjects had normal oral glucose tolerance. The insulin secretion rate (ISR) was derived by deconvolution of plasma C-peptide levels and the insulin MCR (MCRI) by dividing the 0-180 min area under the curve (AUC) of ISR by that of plasma insulin levels (IRI). The insulin sensitivity index (SI) and the glucose effectiveness index (SG) were calculated using Bergman's minimal model. Before gastroplasty, obese subjects showed higher AUC-IRI (P < 0.001) and AUC-ISR (P < 0.02), lower MCRI (P < 0.005) and SI (P < 0.002), but similar SG values, compared to nonobese controls. After gastroplasty, the AUC-IRI dramatically decreased, due to both a reduction of AUC-ISR (from 58,252 +/- 8,437 to 36,675 +/- 4,274 pmol; P < 0.05) and an increase in MCRI (from 658 +/- 117 to 1,299 +/- 127 mL/min.m-2; P < 0.02). SI significantly rose from 4.74 +/- 0.74 to 9.15 +/- 0.96 10(-5) min-1/pmol.L (P < 0.01), whereas SG remained unchanged. All of these parameters became similar to those in nonobese controls (respectively, 32,522 +/- 3,458, 1,180 +/- 101, and 8.48 +/- 1.25; all P = NS). In conclusion, after gastroplasty-induced normalization of body weight, postobese women recover normal insulin secretion, clearance, and action on glucose metabolism. [less ▲]

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See detailPathophysiological response of bovine pulmonary function to gastric distension
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Journal of Comparative Pathology (1995), 112

The purpose was to determine whether gastric overdistension leads to lifethreatening perturbations of pulmonary gas exchange in healthy calves. Six animals were studied with normal (0 kPa) and increased ... [more ▼]

The purpose was to determine whether gastric overdistension leads to lifethreatening perturbations of pulmonary gas exchange in healthy calves. Six animals were studied with normal (0 kPa) and increased (1, 2, 3, 4 and 5 kPa) intragastric pressure (IGP). Changes in pleural pressures and peak expiratory flow paralleled those of IGP. Inspiratory pressure-time index remained stable throughout the insufflation process. Pulmonary function values were characterized by abrupt changes with increasing IGP. Tidal volume declined as IGP increased and, along with inspiratory flow, decreased abruptly with the highest pressure (5 kPa). Respiratory rate progressively increased up to an IGP of 4 kPa, then decreased by 30%, due to breath-holding at the end of inspiration. Minute volume increased with IGP up to 4 kPa, but dramatically declined at 5 kPa. Total pulmonary resistance remained stable throughout the insufflation process, whereas lung dynamic compliance fell abruptly to one-half of its baseline value at IGPs of 1 kPa and above. Arterial oxygen tension was maintained at an IGP of 1 kPa, slightly diminished at 2–3 kPa, and markedly decreased at 4–5 kPa. Hypercapnia and respiratory acidosis developed progressively with increasing IGP. Changes in arterial gases were probably due to a combination of (1) alveolar hypoventilation, caused by altered tidal to dead space volume ratio, inadequate central nervous system “drive”, altered effectiveness of inspiratory muscle action, or end-inspiratory breath-holding, and (2) ventilation to perfusion mismatch, caused by perfusion of collapsed lung units. In the range of IGPs used, standardized arterial pH did not decline below the control value, which suggests that perfusion of peripheral tissues remained sufficient, and that respiratory failure rather than cardiovascular failure may be the principal physiopathological effect of increased gastric pressure [less ▲]

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See detailLes insuffisances mitrales ischémiques: principes de leur traitement chirurgical
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 295-7

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou ... [more ▼]

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou chroniques de la maladie ischémique. Leur compréhension est facilité par la classification fonctionnelle de Carpentier. A l'occasion de cette revue, nous précisons les indications elles modalités de traitement de ce type d'insuffisance mitrale. [less ▲]

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See detailImproving the action of insulin.
Lefebvre, Pierre ULg; Scheen, André ULg

in Clinical & Investigative Medicine = Médecine Clinique et Experimentale (1995), 18(4), 340-7

Improving the action of insulin is a relatively new concept in diabetes management. Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by ... [more ▼]

Improving the action of insulin is a relatively new concept in diabetes management. Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by correcting a subclinical magnesium deficiency. Pharmacological means of improving insulin action include metformin, antiobesity serotoninergic agents and, possibly, benfluorex. New compounds aiming at improving the action of insulin are in development and include thiazolidinedione derivatives (known as "insulin sensitizers"), inhibitors of adipose tissue lipolysis (e.g. acipimox), and inhibitors of free fatty acid oxidation (e.g. etomoxir). Avoidance of drugs that reduce insulin sensitivity, such as beta blockers and thiazide diuretics, is recommended. Finally, cigarette smoking is associated with resistance to insulin but it remains to be demonstrated that cessation of cigarette smoking does in fact increase sensitivity to insulin. [less ▲]

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See detailLes routes de la foi en pays mosan (IVe-XVe siècles). Sources, méthode et problématique
George, Philippe ULg

in Feuillets de la Cathédrale de Liège (1995)

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See detailINVESTIGATION OF THE ELECTRICAL-RESISTIVITY BEHAVIOR BETWEEN THE KOSTERLITZ-THOULESS TEMPERATURE AND THE GINZBURG-LANDAU TEMPERATURE IN SPRAY-DRIED BULK BI2SR2CACU2O8+D - THE ROLE OF 2-DIMENSIONAL FLUCTUATIONS AND DEFECTS
Ausloos, Marcel ULg; Bougrine, Hassan ULg; DUVIGNEAUD, P. H. et al

in Physica C (1995), 251(3-4), 337-347

The resistive transition R(T) between the Kosterlitz-Thouless temperature and the Ginzburg-Landau temperature was studied in spray-dried bulk Bi2Sr2CaCu2O8+d superconductors for a magnetic-field range ... [more ▼]

The resistive transition R(T) between the Kosterlitz-Thouless temperature and the Ginzburg-Landau temperature was studied in spray-dried bulk Bi2Sr2CaCu2O8+d superconductors for a magnetic-field range between 0 and 0.3 T. The samples were prepared by the spray-drying technique with Bi2+xSr2-x-yCa2+yCu2O8+d for x = y = 0.05 or 0.1 as a starting composition here. The data analysis was performed assuming various resistive laws previously proposed. When numerically analyzed in terms of a two-dimensional Kosterlitz-Thouless theory the results lead to remarkable quantitative agreement. This implies that the R(T) behavior can be described within a picture of a highly two-dimensional behavior of macroscopic fluctuations of vortex-antivortex depairing type. The role of defects or inhomogeneities in the resistive behavior is outlined. [less ▲]

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See detailGlucose inhibits human placental GH secretion, in vitro
Patel, N.; Alsat, E.; Igout, Ahmed ULg et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(5), 1743-6

Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation ... [more ▼]

Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation remains unknown. In this study the effect of glucose on PGH secretion by human term placenta was tested, in vitro, by means of two different experimental models: organ culture of villous tissue and primary culture of isolated cytotrophoblasts. PGH was assayed in the culture medium by an immunoradiometric assay using a specific PGH monoclonal antibody. The presence of glucose (25 mmol/L) in the culture medium significantly inhibited (p < 0.001) the secretion of PGH by either placental villous explants or by cultured trophoblast cells. This inhibitory effect of glucose on PGH secretion was dose-dependent. More than 50% inhibition being observed with 5.5 mmol/L. In the same conditions, the daily production of hPL and hCG, were unmodified. Furthermore, the glucose-induced inhibition of PGH secretion was more effective when cultured trophoblast cells are differentiated into syncytiotrophoblast. This study demonstrates, for the first time, that among the gestational polypeptide hormones secreted by the human placenta, only PGH secretion is modulated by glucose, suggesting a key metabolic role for this hormone during pregnancy. [less ▲]

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See detailTRANSPORT STUDY OF BA-DEFICIENT THIN-FILM Y123 SUPERCONDUCTORS ENRICHED WITH NA
PEKALA, M.; Bougrine, Hassan ULg; AZOULAY, J. et al

in Superconductor Science & Technology (1995), 8(8), 660-666

Nominal Y0.3Ba0.6Na0.1CuO3-delta thin films were prepared with small grains having an orientation of the c axis perpendicular to the MgO substrate. The electrical resistivity and the thermoelectric power ... [more ▼]

Nominal Y0.3Ba0.6Na0.1CuO3-delta thin films were prepared with small grains having an orientation of the c axis perpendicular to the MgO substrate. The electrical resistivity and the thermoelectric power in the absence and in the presence of a magnetic field are reported. The magnetic field dependence of the irreversibility line is discussed. The role of the field for disentangling intragrain and intergrain effects in both coefficients is emphasized. [less ▲]

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See detailMiospore Biozonation in the Middle Devonian - Lower Carboniferous of Europe : its application to Western Gondwana
Loboziak, S.; Streel, Maurice ULg

in Anais da Academia Brasileira de Ciencias (1995), 67(3), 311-312

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See detailANISOTROPY OF THE MIXED-STATE IN TEXTURED PB-FREE BI-2223 SUPERCONDUCTOR - ELECTRICAL-RESISTIVITY, SEEBECK AND NERNST EFFECTS
PEKALA, M.; Bougrine, Hassan ULg; LADA, T. et al

in Superconductor Science & Technology (1995), 8(9), 726-739

Anisotropy of transport entropy and of Hall angle are reported for the first time through various electrical and thermal transport properties, such as the electric resistivity and the Seebeck and the ... [more ▼]

Anisotropy of transport entropy and of Hall angle are reported for the first time through various electrical and thermal transport properties, such as the electric resistivity and the Seebeck and the Nernst effects (in the presence of a magnetic field ranging between 0 and 4 T), measured for a Pb-free textured Bi-2223 system. The field and temperature influence in the mixed state region is reported only for the H parallel to a and H parallel to c cases and the temperature gradient applied along the b direction. A much stronger influence of magnetic field along the c than the a axis is demonstrated. The relative evolution of the so-called 'excess transport effects' is discussed. We show the laws relating the respective losses to the applied magnetic field. This leads us to the understanding that anisotropic vortex kinetics exist in these systems. We consequently propose two original routes of theoretical investigations to be considered for the calculation of Nernst and TEP effects in a field, in particular to consider a vortex-carrier drag phenomenon. [less ▲]

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See detailPacemaker Implantation for Early Sinus Node Dysfunction after Orthotopic Heart Transplantation
RADERMECKER, Marc ULg; Defraigne, Jean-Olivier ULg; Fourny, J. et al

in Acta Chirurgica Belgica (1995), 95(1), 31-4

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node ... [more ▼]

Among 60 patients who received OHT at our institution between November 1986 and January 1990, 4 actually needed implantation of a permanent pacemaker. Three patients with symptomatic early sinus node dysfunction were identified and were satisfactorily paced on the VVIR mode. All three showed sinus recovery within three months following implantation and had their pacemaker switched from the VVIR mode to a simple ventricular demand pacing. Interestingly, administration of beta-blocking drugs quickly reinstituted pace dependence. The patients' outcome is excellent (18 to 48 months follow-up). No difference with the global cohort of our OHT recipients was noticed, apart from an apparent high incidence of infections (3/3) with (2/3) CMV and severe rejection (3/3) during the first month postoperatively. This data suggests that sinus dysfunction may be the result of a multifactorial (rejection, CMV, ...) injury to the conduction system, and is only clinically relevant beyond a threshold level. Denervation hypersensitivity, together with correction of these factors, may account for the restoration of a sufficient reserve of conduction system, and therefore appropriate sinus node function in basal conditions. [less ▲]

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See detailELECTRICAL AND THERMOMAGNETIC EFFECTS IN BI1.7PB0.3SR2CA2CU3O10 SUPERCONDUCTING CERAMICS
Pekala, M.; Bougrine, Hassan ULg; Ausloos, Marcel ULg

in Journal of Physics : Condensed Matter (1995), 7(28), 5607-5621

We report the electrical resistivity and thermoelectric power of polycrystalline Pb-doped Pi 2:2:2:3 superconductors. In particular the mixed-state properties are investigated by measuring the ... [more ▼]

We report the electrical resistivity and thermoelectric power of polycrystalline Pb-doped Pi 2:2:2:3 superconductors. In particular the mixed-state properties are investigated by measuring the longitudinal and transverse (Nernst) thermoelectric power. For the first time we show the presence of hysteresis in a high magnetic field for the Nernst effect. We discuss the variation with magnetic field in the properties with respect to the zero-field case and show the power-law behaviour with exponents depending on the transport quantity. We extract 'derived properties' such as the effective mass, the transport entropy, the Ginzburg-Landau parameter, the thermal Hall angle and the activation energy and compare them with previous data on related systems. [less ▲]

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See detailModulation of the Expression of Interstitial and Type-Iv Collagenases in Coculture of Ht1080 Fibrosarcoma Cells and Fibroblasts
Munaut, Carine ULg; Noël, Agnès ULg; Weidle, U. H. et al

in Invasion & Metastasis (1995), 15(5-6), 169-78

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases ... [more ▼]

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases (gelatinases A and B) in a model of coculture of human fibroblasts and HT 1080 fibrosarcoma cells. The interstitial collagenase activity, mainly found in the conditioned medium of fibroblasts, and its mRNA level were increased in the in vitro coculture model. In contrast, gelatinase A was produced by both cell types. The HT 1080 cells additionally synthesised gelatinase B. In coculture, an enhancement of gelatinase A and the presence of its activated form were observed. Northern blot analysis demonstrated that this enzymatic enhancement occurred at a pretranslational level. The stimulation of the interstitial collagenase activity was partially mediated through soluble factor(s), whereas increased gelatinase A appeared to require direct cell-cell interactions. The extracellular matrix component, type-I collagen, stimulated the enzymatic activities released by the individual cells, but it did not modulate the synthesis of interstitial collagenase in coculture. Our results demonstrate that distinct MMPs are modulated by distinct mechanisms, all depending on specific interactions between tumour cells and host fibroblasts. [less ▲]

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See detailSpatio-temporal aquatic vegetation patterns in former channels in relation to their isolation from the river Rhine (Eastern France)
Klein, J. P.; Robach, F.; Vanderpoorten, Alain ULg et al

in Acta Botanica Gallica : Bulletin de la Société Botanique de France (1995), 142

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See detailUn cimetière, une communauté, un espace : l’exemple liégeois
Schmitz, Serge ULg

in Géographie et cultures (1995), 16

The article is the result of the study of 160 years of cemetery history in an urban region which houses today 510.000 peoples. It demonstrates the strong links between urban and rural communities and ... [more ▼]

The article is the result of the study of 160 years of cemetery history in an urban region which houses today 510.000 peoples. It demonstrates the strong links between urban and rural communities and their cemeteries. In order to do this, four points in cemetery history, chosen for the availability of reliable and comparable sources, have been chosen and described successively. Finally the article investigates the reasons for the exponential growth of requiered cemetery size. [less ▲]

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See detailCompressive strength for service and accident conditions
Schneider, Ulrich; Schwesinger, P.; Debicki, Gérard et al

in Materials and Structures (1995), 28(181), 410-414

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See detailThe role of the insurance industry in piloting private sector security and prevention policy
Lemaître, André ULg

in European Journal on Criminal Policy and Research (1995), 3.1

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See detailLe rôle du foie dans l'homéostasie glucidique: une relecture des travaux de Claude Bernard
Lefebvre, P.; PAQUOT, Nicolas ULg; SCHEEN, André ULg

in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (1995)

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See detailLa grammaire au secours de la datation des textes
Winand, Jean ULg

in Revue d'Egyptologie (1995), 46

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See detailNF-kappaB transcription factor activation by hydrogen peroxide can be decreased by 2,3-dihydroxybenzoic acid and its ethylester derivative
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in Archives of Biochemistry & Biophysics (1995)

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See detailSpecific bovine brucellosis diagnosis based on in vitro antigen-specific gamma interferon production.
Weynants, V.; Godfroid, J.; Limbourg, B. et al

in Journal of Clinical Microbiology (1995), 33(3), 706-12

In order to improve the specificity of the diagnosis of bovine brucellosis, we developed a test which can be regarded as an in vitro correlate of the delayed-type hypersensitivity test (DTH). A mixture of ... [more ▼]

In order to improve the specificity of the diagnosis of bovine brucellosis, we developed a test which can be regarded as an in vitro correlate of the delayed-type hypersensitivity test (DTH). A mixture of cytoplasmic proteins from Brucella melitensis B115 was used as a specific antigenic stimulus in bovine whole blood culture. Supernatants harvested at 18 to 24 h after the in vitro antigenic stimulus were assayed for their gamma interferon (IFN-gamma) content by using a commercial sandwich enzyme-linked immunosorbent assay kit. The IFN-gamma assay was evaluated with 10 heifers during the course (80 days) of an experimental infection and with 14 cows from an ongoing brucellosis outbreak. All of these animals were slaughtered, and pertinent organs were subjected to classical bacteriological analyses. In addition, we analyzed 23 field cases in which false-positive serological reactions occurred. The IFN-gamma results were compared with those of the standard DTH and a battery of serological assays, and they were correlated with bacteriological data. Both for the experimental infection and for the field brucellosis outbreak, the IFN-gamma assay detected infection in more animals than any combination of the serological tests, and it detected infection earlier than these tests. Finally, none of the samples from cows showing false-positive serological reactions was classified as positive by the IFN-gamma assay, attesting to its specificity and to its usefulness in interpreting ambiguous serological results. A rapid and convenient alternative to the DTH, the IFN-gamma assay appears to be an ideal method that is complementary to the serological diagnosis protocols. [less ▲]

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See detailTransgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
Plumier, Jean-Christophe ULg; Ross, B.; Currie, R. W. et al

in Journal of Clinical Investigation (1995), 95(4), 1854-60

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock ... [more ▼]

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock proteins, the amount of the inducible heat shock protein 70 (HSP70) and the level of myocardial protection. The inducible HSP70 has also been shown to be protective in transfected myogenic cells. Here we examined the role of human inducible HSP70 in transgenic mouse hearts. Overexpression of the human HSP70 does not appear to affect normal protein synthesis or the stress response in transgenic mice compared with nontransgenic mice. After 30 min of ischemia, upon reperfusion, transgenic hearts versus nontransgenic hearts showed significantly improved recovery of contractile force (0.35 +/- 0.08 versus 0.16 +/- 0.05 g, respectively, P < 0.05), rate of contraction, and rate of relaxation. Creatine kinase, an indicator of cellular injury, was released at a high level (67.7 +/- 23.0 U/ml) upon reperfusion from nontransgenic hearts, but not transgenic hearts (1.6 +/- 0.8 U/ml). We conclude that high level constitutive expression of the human inducible HSP70 plays a direct role in the protection of the myocardium from ischemia and reperfusion injury. [less ▲]

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See detailRadiochirurgie et radiothérapie stéréotaxique
Coucke, Philippe ULg; FANKHAUSER

in Médecine et Hygiène (1995), 53(2088), 2002--2009

La radiochirurgie, appelée radiothérapie stéréotaxique lorsqu'il s'agit d'un traitement fractionné, s'effectue en Suisse depuis 1993, soit par accélérateur linéaire modifié, soit par Gamma Knife. Par ... [more ▼]

La radiochirurgie, appelée radiothérapie stéréotaxique lorsqu'il s'agit d'un traitement fractionné, s'effectue en Suisse depuis 1993, soit par accélérateur linéaire modifié, soit par Gamma Knife. Par cette technique on arrive à administrer une dose élevée de radiations à des lésions intracrâniennes circonscrites d'une taille de 3 à 4 cm au maximum, tout en ménageant les tissus normaux avoisinants. Lorsque les lésions sont plus grandes, mal délimitées, ou de forme irrégulière, c'est la radiothérapie conventionnelle et conformationnelle qui offre une meilleure répartition des doses. Les principales lésions considérées pour la radiochirurgie sont les malformations artérioveineuses, les métastases cérébrales solitaires, les méningiomes de la base, les schwannomes vestibulaires et certaines récidives focales de gliomes. [less ▲]

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See detailAutovidéoscopie et formation des enseignants: les techniques d'analyse de gestes
Cloes, Marc ULg; Piéron, Maurice

in Eduquer et former. Théories et pratiques (1995), 3/4

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation ... [more ▼]

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation des techniques d'analyse de gestes sur vidéo et d'enseignement simulé. L'articulation de l'analyse avec la littérature scientifique du domaine laisse une grande liberté de transposition vers d'autres champs d'application. [less ▲]

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See detail7-Methyl-3-methylthio-4H-pyrido[4,3-e]-1,2,4-thiadiazin-7-ium-4-ide 1,1-dioxide zwitterion
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailVariable location of the enterotoxin gene (cpe) in Clostridium perfringens.
Cornillot, Emmanuel; Saint-Joanis, Brigitte; Daube, Georges ULg et al

in Molecular Microbiology (1995), 15

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See detailR&D, technological progress and efficiency change in industrial activities
Perelman, Sergio ULg

in Review of Income and Wealth (1995), (41), 349-366

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic ... [more ▼]

The objective of this paper is to estimate total factor productivity growth (TFP) in an international and sectoral setting using two alternative approaches based on the estimation of parametric stochastic frontiers and non-parametric production frontiers (DEA). The TFP is decomposed into two components, technological progress and efficiency change, that can also be interpreted as the results of the innovation and catching-up process, respectively. Finally their relationship is tested with a set of potential explanatory variables that includes R&D expenditures, international competition, and structural characteristics. It appears that the distinction between technological and efficiency performances does matter and must be taken into account in the design of industrial policy. [less ▲]

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See detail3,7-Dimethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide zwitterion
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailA propos des «carnets» d'un pacifiste chrétien : Jean Van Lierde
Jadoulle, Jean-Louis ULg

in Revue d'Histoire Religieuse du Brabant-Wallon (1995), t. IX(fasc. 1), 21-36

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See detailNimesulide
Dupont, L.; Pirotte, Bernard ULg; Masereel, B. et al

in Acta Crystallographica (1995)

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See detailEntre sémantique et syntaxe. Pour une classification des lexèmes verbaux en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

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See detail3-Methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailÀ propos des graphies dans les Late Ramesside Letters
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

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See detailHysteroscopic myomectomy.
Donnez, Jacques; Polet, Roland; Smets, Mireille et al

in Current Opinion in Obstetrics & Gynecology (1995), 7(4), 311-6

Transhysteroscopic myomectomy has proved to be safe and effective with experienced operators. The use of the continuous flow hysteroscope and preoperative monitoring of intrauterine pressure has ... [more ▼]

Transhysteroscopic myomectomy has proved to be safe and effective with experienced operators. The use of the continuous flow hysteroscope and preoperative monitoring of intrauterine pressure has contributed to the prevention of fluid intravasion accidents. Effectiveness has been demonstrated in a number of recently published long-term studies. [less ▲]

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See detailUtilisation des matières grasses chez les bovins à l'engraissement
Clinquart, Antoine ULg; Micol, Didier; Brundseaux, Christophe et al

in Productions Animales (1995), 8

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See detailN2-cyano-N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulfonyl]guanidine
Dupont, L.; Masereel, B.; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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