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See detailDes histoires du cinéma en images et en sons
Belloi, Livio ULg

in Iris - Revue de théorie de l'image et du son/A Journal of Theory on Image and Sound (1995), 19(automne), 75-98

Etude de quelques fictions réflexives (dont "Singin' in the Rain" de Stanley Donen et Gene Kelly) au travers desquelles, se mettant au miroir, le cinéma réfléchit sur sa propre histoire et sur ses jalons ... [more ▼]

Etude de quelques fictions réflexives (dont "Singin' in the Rain" de Stanley Donen et Gene Kelly) au travers desquelles, se mettant au miroir, le cinéma réfléchit sur sa propre histoire et sur ses jalons essentiels. [less ▲]

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See detailTreatment of patent ductus arteriosus by placement of intravascular coils in a pup
Snaps, Frédéric ULg; Mc Entee, Kathleen ULg; Saunders, J. et al

in Journal of the American Veterinary Medical Association [=JAVMA] (1995), 6(6), 724-725

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a ... [more ▼]

A 3-month-old female mixed-breed pup was referred for evaluation and treatment of patent ductus arteriosus (PDA). Selective angiography was performed to confirm the diagnosis. A cone-shaped PDA with a large aortic base was outlined. A second selective angiographic procedure was performed to functionally close the PDA by use of thrombotic coils; complete obstruction was obtained. Twenty-four hours after the procedure, the murmur disappeared. One month later, the dog was reexamined and found to be clinically normal. [less ▲]

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See detailELECTRICAL AND THERMOMAGNETIC EFFECTS IN BI1.7PB0.3SR2CA2CU3O10 SUPERCONDUCTING CERAMICS
Pekala, M.; Bougrine, Hassan ULg; Ausloos, Marcel ULg

in Journal of Physics : Condensed Matter (1995), 7(28), 5607-5621

We report the electrical resistivity and thermoelectric power of polycrystalline Pb-doped Pi 2:2:2:3 superconductors. In particular the mixed-state properties are investigated by measuring the ... [more ▼]

We report the electrical resistivity and thermoelectric power of polycrystalline Pb-doped Pi 2:2:2:3 superconductors. In particular the mixed-state properties are investigated by measuring the longitudinal and transverse (Nernst) thermoelectric power. For the first time we show the presence of hysteresis in a high magnetic field for the Nernst effect. We discuss the variation with magnetic field in the properties with respect to the zero-field case and show the power-law behaviour with exponents depending on the transport quantity. We extract 'derived properties' such as the effective mass, the transport entropy, the Ginzburg-Landau parameter, the thermal Hall angle and the activation energy and compare them with previous data on related systems. [less ▲]

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See detailConformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Research Communications In Molecular Pathology and Pharmacology (1995), 90(1), 153-64

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation ... [more ▼]

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation of the molecular hydrophobicity potential. The calcium complexes formed with KAD-1229, A-4166, repaglinide or its enantiomer, displayed favourable attributes to act as ionophores. Such was not the case for the poorly efficient insulinotropic agent meglitinide and the biologically inactive enantiomer of A-4166. The configuration of the calcium complex formed with S 3075 also failed to display the features required for a high ionophoretic capacity. [less ▲]

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See detailEvaluacion del comportamiento agressivo en ninos preescolares
Born, Michel ULg; Egido, A.; Pire, B.

in Revista Galega de Psicopedagogia (1995), 12(8), 149-165

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See detailAutovidéoscopie et formation des enseignants: les techniques d'analyse de gestes
Cloes, Marc ULg; Piéron, Maurice

in Eduquer et former. Théories et pratiques (1995), 3/4

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation ... [more ▼]

Se référant aux résultats de plusieurs recherches prenant pour cadre la formation d'enseignants en éducation physique, les auteurs apportent des éléments de réponses quant à la pertinence de l'utilisation des techniques d'analyse de gestes sur vidéo et d'enseignement simulé. L'articulation de l'analyse avec la littérature scientifique du domaine laisse une grande liberté de transposition vers d'autres champs d'application. [less ▲]

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See detailSynthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics
Masereel, B.; Dupont, L.; Laeckmann, D. et al

in European Journal of Medicinal Chemistry (1995), 30

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See detailINVESTIGATION OF THE ELECTRICAL-RESISTIVITY BEHAVIOR BETWEEN THE KOSTERLITZ-THOULESS TEMPERATURE AND THE GINZBURG-LANDAU TEMPERATURE IN SPRAY-DRIED BULK BI2SR2CACU2O8+D - THE ROLE OF 2-DIMENSIONAL FLUCTUATIONS AND DEFECTS
Ausloos, Marcel ULg; Bougrine, Hassan ULg; DUVIGNEAUD, P. H. et al

in Physica C (1995), 251(3-4), 337-347

The resistive transition R(T) between the Kosterlitz-Thouless temperature and the Ginzburg-Landau temperature was studied in spray-dried bulk Bi2Sr2CaCu2O8+d superconductors for a magnetic-field range ... [more ▼]

The resistive transition R(T) between the Kosterlitz-Thouless temperature and the Ginzburg-Landau temperature was studied in spray-dried bulk Bi2Sr2CaCu2O8+d superconductors for a magnetic-field range between 0 and 0.3 T. The samples were prepared by the spray-drying technique with Bi2+xSr2-x-yCa2+yCu2O8+d for x = y = 0.05 or 0.1 as a starting composition here. The data analysis was performed assuming various resistive laws previously proposed. When numerically analyzed in terms of a two-dimensional Kosterlitz-Thouless theory the results lead to remarkable quantitative agreement. This implies that the R(T) behavior can be described within a picture of a highly two-dimensional behavior of macroscopic fluctuations of vortex-antivortex depairing type. The role of defects or inhomogeneities in the resistive behavior is outlined. [less ▲]

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See detail3-Methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailTRANSPORT STUDY OF BA-DEFICIENT THIN-FILM Y123 SUPERCONDUCTORS ENRICHED WITH NA
PEKALA, M.; Bougrine, Hassan ULg; AZOULAY, J. et al

in Superconductor Science & Technology (1995), 8(8), 660-666

Nominal Y0.3Ba0.6Na0.1CuO3-delta thin films were prepared with small grains having an orientation of the c axis perpendicular to the MgO substrate. The electrical resistivity and the thermoelectric power ... [more ▼]

Nominal Y0.3Ba0.6Na0.1CuO3-delta thin films were prepared with small grains having an orientation of the c axis perpendicular to the MgO substrate. The electrical resistivity and the thermoelectric power in the absence and in the presence of a magnetic field are reported. The magnetic field dependence of the irreversibility line is discussed. The role of the field for disentangling intragrain and intergrain effects in both coefficients is emphasized. [less ▲]

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See detail7-Methyl-3-methylthio-4H-pyrido[4,3-e]-1,2,4-thiadiazin-7-ium-4-ide 1,1-dioxide zwitterion
Dupont, L.; De Tullio, Pascal ULg; Pirotte, Bernard ULg et al

in Acta Crystallographica (1995), C51

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See detailPropagations en réseaux de cours d'eau d'ondes de crues incluant des ressauts
Pirotton, Michel ULg

in Tribune de l'Eau (La) (1995), 49(574), 23-33

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See detailTransgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
Plumier, Jean-Christophe ULg; Ross, B.; Currie, R. W. et al

in Journal of Clinical Investigation (1995), 95(4), 1854-60

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock ... [more ▼]

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock proteins, the amount of the inducible heat shock protein 70 (HSP70) and the level of myocardial protection. The inducible HSP70 has also been shown to be protective in transfected myogenic cells. Here we examined the role of human inducible HSP70 in transgenic mouse hearts. Overexpression of the human HSP70 does not appear to affect normal protein synthesis or the stress response in transgenic mice compared with nontransgenic mice. After 30 min of ischemia, upon reperfusion, transgenic hearts versus nontransgenic hearts showed significantly improved recovery of contractile force (0.35 +/- 0.08 versus 0.16 +/- 0.05 g, respectively, P < 0.05), rate of contraction, and rate of relaxation. Creatine kinase, an indicator of cellular injury, was released at a high level (67.7 +/- 23.0 U/ml) upon reperfusion from nontransgenic hearts, but not transgenic hearts (1.6 +/- 0.8 U/ml). We conclude that high level constitutive expression of the human inducible HSP70 plays a direct role in the protection of the myocardium from ischemia and reperfusion injury. [less ▲]

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See detailEntre sémantique et syntaxe. Pour une classification des lexèmes verbaux en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

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See detailComment explorer la sensibilite a l'insuline chez l'homme?
Scheen, André ULg; Paquot, Nicolas ULg; Letiexhe, Michel ULg et al

in Annales d'Endocrinologie (1995), 56(5), 523-30

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose ... [more ▼]

The two most widely used methods for studying insulin sensitivity in man are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model assessment. The glucose clamp is the reference method, well validated and easy to interpret, which allows various extensions to the basic experimental procedure in order to obtain more valuable information on the specific effects of insulin on the various aspects of glucose metabolism. However, it is time-consuming and labour-intensive. In contrast, the intravenous glucose tolerance test is easier to perform, but its interpretation is much more difficult and requires a modeling approach called the "minimal model". If the intravenous glucose tolerance test probably represents a good screening test, mainly on a population basis, the glucose clamp still remains the gold standard method to study insulin sensitivity in man. [less ▲]

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See detailÀ propos des graphies dans les Late Ramesside Letters
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1995), 4

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See detailNimesulide
Dupont, L.; Pirotte, Bernard ULg; Masereel, B. et al

in Acta Crystallographica (1995), C51

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See detailBeyond Borders. West European Migration Policy towards the 21st Century de S. Collinson
Martiniello, Marco ULg

in Ethnic and Racial Studies (1995), 18(2), 421-422

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See detailCoexpression of cytokeratin and vimentin in eutopic endometrium and endometriosis throughout the menstrual cycle: evaluation by a computerized method.
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Donnez, Jacques

in Fertility and Sterility (1995), 64(1), 69-75

Objectives: To evaluate quantitatively cytokeratin and vimentin staining in glandular and stromal cells of eutopic and ectopic endometrium. DESIGN: The investigation of cytokeratin and vimentin was ... [more ▼]

Objectives: To evaluate quantitatively cytokeratin and vimentin staining in glandular and stromal cells of eutopic and ectopic endometrium. DESIGN: The investigation of cytokeratin and vimentin was carried out using the new computerized technology of image analysis. SETTING: University Hospital, Department of Gynecology. PATIENTS: Biopsies were taken from patients undergoing a laparoscopy for infertility (29 endometrial biopsies and 31 biopsies of peritoneal endometriosis). None of them were treated. RESULTS: Cyclic variations of cytokeratin and vimentin staining were noted in eutopic endometrium. The cytokeratin and vimentin staining pattern consistently was lower in ectopic endometrium than in eutopic endometrium. CONCLUSIONS: Endometriotic epithelial and stromal cells undergo a complex program of differentiation giving them histochemical characteristics similar to those observed in endometrium. Such a concomitant expression of antigenicity indicates their close relationship with their mesodermal müllerian origin. [less ▲]

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See detailLa grammaire au secours de la datation des textes
Winand, Jean ULg

in Revue d'Egyptologie (1995), 46

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See detailHydroxychloroquine (Plaquenil) for recurrence prevention of Crohn's disease after curative surgery.
Louis, Edouard ULg; Belaiche, Jacques ULg

in Gastroentérologie Clinique et Biologique (1995), 19(2), 233-4

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See detailLes cellules dendritiques folliculaires: phenotype, origine et fonctions.
Heinen, Ernst ULg

in Pathologie Biologie (1995), 43(10), 848-57

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic ... [more ▼]

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic cells presenting antigens to T cells. They are long-lived and derived from local mesenchymal cells. Their complex cytoplasmic extensions, covered with dendrites, are intermingled in a network which surrounds germinal B and T cells. On their surface, receptors fix immune complexes without endocytosis and adhesion molecules ensure close contacts to the lymphoid cells. FDC influence the migration, activation, proliferation, survival and differentiation of B cells into memory cells and probably act also on the germinal center T cells. [less ▲]

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See detailLa recherche scientifique et l'invention d'une société solidaire
de Landsheere, Gilbert ULg

in Bulletin de l'Association de la Noblesse du Royaume de Belgique (1995), (206), 22-28

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See detailN2-cyano-N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulfonyl]guanidine
Dupont, L.; Masereel, B.; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailUtilisation des matières grasses chez les bovins à l'engraissement
Clinquart, Antoine ULg; Micol, Didier; Brundseaux, Christophe et al

in Productions Animales (1995), 8

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See detailEscape into Innocence: Ian McEwan and the Nightmare of History
Delrez, Marc ULg

in Ariel : A Review of International English Literature (1995), 26(2), 7-23

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See detailA Frequency-Domain Processor for ScanSAR Images
Barbier, Christian ULg; Rosello-Guasch, Josep

in Preparing for the Future (1995), 5(4), 6-7

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See detailRecent advances in the chemistry of potassium channel openers
Pirotte, Bernard ULg; Fontaine, J.; Lebrun, P.

in Current Medicinal Chemistry (1995), 2

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See detailLong run behaviour of Pacific-Basin stock prices
Corhay, Albert ULg; Tourani-Rad, Alireza; Urbain, Jean-Pierre ULg

in Applied Financial Economics (1995), 5(1), 11-18

In this paper, we investigate the long run relationship among five major Pacific-Basin stock markets. We focus on the common long run behaviour of their stock price indices over a sample period of 20 ... [more ▼]

In this paper, we investigate the long run relationship among five major Pacific-Basin stock markets. We focus on the common long run behaviour of their stock price indices over a sample period of 20 years. Using cointegration theory, we find that while there exists a rather integrated Pacific Basin financial area, the regional aspects (Asian versus Pacific) play important roles. [less ▲]

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See detailStromelysin-3 - a paradigm of extracellular proteinase expressed in stromal cells of human carcinomas.
Basset, P.; Rouyer, N.; Wolf, C. et al

in Cell Biology International (1995), 19(3), 242-242

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See detailISOLATION OF SUCROSE SYNTHASE FROM RICE (ORYZA-SATIVA) GRAINS IN PILOT-SCALE FOR APPLICATION IN CARBOHYDRATE SYNTHESIS
ELLING, Lothar; GULDENBERG, Birgit; GROTHUS, Marita et al

in Biotechnology & Applied Biochemistry (1995), 21(Part 1), 29-37

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the ... [more ▼]

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the 9 kg scale of rice (Oryza sativa) grains was achieved in five steps with 11.3% yield and 192-fold purification. The final sucrose synthase preparation was free of nucleotide di- and monophosphatases, but did contain 0.05% of both invertase and UDP-glucose-hydrolysing activity. It can be efficiently utilized for the synthesis of activated sugars. Its application for the synthesis of saccharides is possible taking into account that 15% UDP-glucose is hydrolysed within 15 h incubation time [less ▲]

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See detailCellular and molecular aspects of thymic T-cell education to neurohypophysial peptides
Geenen, Vincent ULg; Martens, Henri ULg; Vandersmissen, Eric et al

in Excerpta Medica (1995), 1098

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See detailConfirmation bias as a social skill
Dardenne, Benoît ULg; Leyens, J.

in Personality & Social Psychology Bulletin (1995), 21

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See detailLes insuffisances mitrales ischémiques: principes de leur traitement chirurgical
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 295-7

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou ... [more ▼]

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou chroniques de la maladie ischémique. Leur compréhension est facilité par la classification fonctionnelle de Carpentier. A l'occasion de cette revue, nous précisons les indications elles modalités de traitement de ce type d'insuffisance mitrale. [less ▲]

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See detail"De l'exequatur et des causes de préférence"
Moreau, Pierre ULg

in Actualités du Droit (1995), (2), 395-410

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See detailDu grec au latin et du latin au grec. Les problèmes de la traduction dans l'antiquité gréco-latine
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1995), 54

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See detailValve Replacement for Acute Left Heart Endocarditis
Detry, Olivier ULg; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Cardiovascular Surgery (1995), 3(5), 529-35

Between January 1982 and June 1993, 66 patients (48 men and 18 women of mean (range) age 50 (21-77) years) underwent valve replacement for acute infective endocarditis. There were 45 aortic valve and 17 ... [more ▼]

Between January 1982 and June 1993, 66 patients (48 men and 18 women of mean (range) age 50 (21-77) years) underwent valve replacement for acute infective endocarditis. There were 45 aortic valve and 17 mitral valve infections. Four patients had bivalvular involvement. Fifty-three patients suffered from native valve endocarditis, with underlying valvular lesions documented for 31 patients. Staphylococci and Streptococci spp. were responsible for 68% of infection, and 20% of blood and valve cultures were negative. Refractory congestive heart failure was the leading surgical indication in 86% of patients. The mean follow-up period was 44 months. The perioperative mortality rate was 6%. Actuarial survival rates were 88.5% at 1 year and 83% at 3 years. No early recurrence of infection was noted. Six patients (9%) needed reoperation. Satisfactory results confirm that early surgical management should be considered in patients with complicated infective endocarditis. [less ▲]

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See detailPotentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks
Schoenen, Jean ULg; Wang, W.; Albert, A. et al

in European Journal of Neurology (1995), 2

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See detailFast Routine Production of L-[11C-methyl]methionine with Al2O3KF
Schmitz, Frédéric; Plenevaux, Alain ULg; Del-Fiore, Guy et al

in Applied Radiation & Isotopes (1995), 46(9), 893-897

No-carrier-added (nca) L-[11C-methyl]methionine was prepared via the very fast S-alkylation of L-homocysteine adsorbed on AI203/KF with [11C]iodomethane at room temperature in ethanol. The alkylation was ... [more ▼]

No-carrier-added (nca) L-[11C-methyl]methionine was prepared via the very fast S-alkylation of L-homocysteine adsorbed on AI203/KF with [11C]iodomethane at room temperature in ethanol. The alkylation was realized with a radiochemical yield of 94 +/- 4% EOB (n = 20). More than 90% (n = 20) of the precursor L-homocysteine remained adsorbed on the solid support and was eliminated by a simple filtration. After reaction, neither racemization nor by-product were detected. The purification process was thus limited to a C18 Sep-Pak followed by an alumina Sep-Pak. The radiochemical purity measured on the final solution was shown to be > 99%. The only chemical contaminant was L-homocysteine (+ 10 µg). With this new technique, L-[11C-methyl]methionine was ready for injection within 10 min from [11C]CO2 with a specific activity ranging around 37 + 5.6 GBq (1 +/- 0.15 Ci)//tmol EOB. Through this procedure L-[11C-methyl]methionine can be prepared without preparative HPLC purification, This is an important simplification for the fast routine production of one of the most widely used radiopharmaceutical compounds for PET. [less ▲]

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See detailPET radiopharmaceuticals in Europe : Current use and data relevant for the formulation of summaries of product characteristics (SPCs)
Meyer, G. J.; Waters, S. L.; Coenen, H. H. et al

in European Journal of Nuclear Medicine (1995), 22(12), 1420-1432

The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task ... [more ▼]

The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task group for licensing PET radiopharmaceuticals; this group has surveyed the use of these compounds in Europe by a questionnaire. The number of PET centres that responded to the questionnaire was 26, which included more than 90% of the larger European PET centres. The survey showed that 2-[18F]fluoro-2-deoxyglucose is by far the most important PET radiopharmaceutical with more than 200 applications per week, followed by [15O]water, [15O]carbonmonoxide, [13N]ammonia, [11C]-l-methionine, andl-6-[18F]fluoro-DOPA. More than 25 other PET radiopharmaceuticals are in regular use, however, at rather low application frequencies. The data were used by the European Pharmacopoeia Commission for its priority rating for requesting the formulation of monographs. Since it is likely that group registrations will be issued by authorities for the PET radiopharmaceuticals, relevant data on toxicity and dosimetry for the formulation of summaries of product characteristics have been collected by the task group as well. [less ▲]

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See detailQuelques alternatives à la régression classique dans le cas de la colinéarité
Palm, Rodolphe ULg; Iemma, A. F.

in Revue de Statistique Appliquée (1995), XLIII(2), 5-33

In this note, we briefly describe some biased regresion methods : principal component regression, latent root regression analysis, partial least square regression, ridge regression and use of James-Stein ... [more ▼]

In this note, we briefly describe some biased regresion methods : principal component regression, latent root regression analysis, partial least square regression, ridge regression and use of James-Stein's estimators. All these methods are illustrated by an example. [less ▲]

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See detailExpertise scientifique et action publique : le cas du changement climatique dans trois pays européens
Mormont, Marc ULg; Dasnoy, Christine ULg

in Natures Sciences Sociétés (1995), 3(&), 16-25

L'expertise scientifique du changement climatique fait l'objet d'une réception très différente en France, en Allemagne et en Belgique. cet état de fait semble lié à la fois à des configurations politiques ... [more ▼]

L'expertise scientifique du changement climatique fait l'objet d'une réception très différente en France, en Allemagne et en Belgique. cet état de fait semble lié à la fois à des configurations politiques différentes, à des procédures spécifiques mais aussi aux stratégies des scientifiques lesquelles dépendent de leur anticipation de cette réception. Cette stratégie des "sources" d'information ne laisse pas de poser des questions sur l'expertise. [less ▲]

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See detailUtilisation de la paille dans des rations d'engraissement: ingestion, dynamique de la digestion et cinétique de dégradabilité dans le rumen
Mayombo, Asangule Pierre; Van Eenaeme, Christian ULg; Gauthier, Sabine et al

in Annales de Zootechnie (1995), 44

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See detailSerological and cutaneous testing of bovine tuberculosis with the A60 antigen complex from Mycobacterium bovis, strain Calmette-Guérin
Saegerman, Claude ULg

in Preventive Veterinary Medicine (1995), 23

A60, a major thermostable macromolecular antigen complex of Mycobacterium bovis strain Calmette-Guerin (BCG), is immunodominant in tuberculosis and able to elicit both humoral and cellular immune ... [more ▼]

A60, a major thermostable macromolecular antigen complex of Mycobacterium bovis strain Calmette-Guerin (BCG), is immunodominant in tuberculosis and able to elicit both humoral and cellular immune reactions in infected hosts. A60-based ELISA and cutaneous tests have been used, in conjunction with the PPD-based skin reaction, in a control group of healthy animals, and in a herd including tuberculous animals. Cutaneous testing with A60 yielded results comparable with those with PPD: both were negative with control cattle and positive with infected animals. Moreover, comparative cutaneous testing with avian tuberculin yielded similar results with PPD and A60. When animals from the infected herd were tested with both avian and bovine sensitins, 54% of cattle were diagnosed as fully positive, 26% suspect, and 20% negative. Serological analysis with the A60-ELISA of part of the infected herd yielded 74% positive, 21% suspect and 5% negative results. Thus, positivity was 74% for serological analysis and 54% for cutaneous testing, whereas positive plus suspect results were 95% for serological analysis and 80% for cutaneous testing. It can be concluded that A60 can be used in place of PPD for cutaneous testing in cattle, and that the diagnostic value of the A60-ELISA is superior to that of the PPD-cutaneous test. [less ▲]

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See detailThe effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine.
Tfelt-Hansen, P.; Henry, P.; Mulder, L. J. et al

in Lancet (1995), 346(8980), 923-6

Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg ... [more ▼]

Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS+MTC) with oral sumatriptan (100 mg) and placebo in 421 patients with migraine. LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57% and 53%, respectively, for the first migraine attack treated. Both treatments were better than placebo (success rate 24%, p < 0.0001). LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p < 0.0001) and was better tolerated (adverse events in 18% and 28%, respectively, p < 0.05). LAS+MTC is as effective as sumatriptan in the treatment of migraine attacks. It is also much cheaper. [less ▲]

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See detailUrbanisme commercial et géographie
Merenne-Schoumaker, Bernadette ULg

in Revue Belge de Géographie (1995), 2(59), 307-315

The paper proposes a short reflection on the commercial planning issue. Five points will be considered : a definition of the urban planning field, a presentation of the methodological problems, the ... [more ▼]

The paper proposes a short reflection on the commercial planning issue. Five points will be considered : a definition of the urban planning field, a presentation of the methodological problems, the underscoring of the five major current challenges (new balance city center - out of town, central areas revival, traditional unplanned shopping center maintenance (or revival), local and neighbourhood centers maintenance, out of town developments planning), the first steps towards a new commercial policy, the analysis of the connections between commercial planning and geography. [less ▲]

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See detailCombined radiotherapy and radioimmotherapy of human colon carcinoma grafted in nude mice.
Buchegger, F; Rojas, A; Delaloye, A et al

in Cancer Research (1995), 55

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were ... [more ▼]

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were selected for being resistant to RIT alone, as is usually the case in the clinical situation. Tumor-bearing mice were treated with a combination of five X-ray fractions over 5 days followed by RIT with two doses of 1.5 mCi 131I-labeled anticarcinoembryonic antigen monoclonal antibody F(ab')2. In Col 12 and LS174T, RIT alone achieved a regrowth delay similar to that of fractionated RT with total doses of 28 and 26 Gy, respectively. In both tumor types, an additive therapeutic effect, measured as increased regrowth delay or local control, was observed when combining RT of different dose levels with RIT. Normal tissue responses were assessed by monitoring acute peak skin reactions and blood cell count. Bone marrow depression for the combination treatment was similar to that of RIT alone; relative to skin, at equitoxic levels, no mice bearing Col 12 tumors were locally controlled with a 32 Gy RT dose alone, while this RT combined with RIT gave a local control of 100%. These studies show a therapeutic benefit when external beam RT is combined with RIT. [less ▲]

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See detailChimiosensibilité in vivo et in vitro de Plasmodium falciparum à Brazzaville (Congo)
Chandenier, Jacques; Ndounga, Mathieu; Carme, Bernard et al

in Santé : Cahiers d'Etude et de Recherches Francophones (1995), 5(1), 25-29

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to ... [more ▼]

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to halofantrine was investigated in an in vitro survey using an isotopic micro test. The resistance rates were 61.8, 14.7, 3.0 and 0.0% respectively. Thus, the chemoresistance which first appeared in 1990 is confirmed and is stable in the population. This finding was further confirmed by a parallel in vitro analysis of sensitivity to chloroquine in Brazzaville. A chloroquine monitoring network is now being established throughout the country based on simplified WHO tests of 100 asymptomatic schoolchildren conducted every six months. The first results in 1993, from three Southern regions indicate that parasites are found in 20 to 60% of cases seven days after a standard 3 day treatment with 25 mg/kg, according to the region. The results of in vitro and in vivo tests are very variable. Indeed, the value of such results for these tests for national monitoring is questionable: a more reliable system of identifying true therapeutic failures would be better suited. [less ▲]

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See detailToxicité potentielle et utilisation pratique du méthotrexate dans la polyarthrite rhumatoïde
Kaye, O.; Ribbens, Clio ULg; Hauwaert, Christian ULg et al

in Médecine et Hygiène (1995)

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See detailMessenger RNA expression for a TSH receptor variant in the thymus of a two-year old child
Paschke, Ralf; Geenen, Vincent ULg

in Journal of Molecular Medicine (1995), 73577-580

We recently described the presence of a TSH receptor variant in orbital tissues. The presence of this TSH receptor variant in the thymus suggests that induction of immune tolerance to this TSH receptor ... [more ▼]

We recently described the presence of a TSH receptor variant in orbital tissues. The presence of this TSH receptor variant in the thymus suggests that induction of immune tolerance to this TSH receptor-transcript is possible. A lack of tolerance induction for this TSH receptor variant could provide an explanation for a possible antigenic link between Graves' disease and thyroid-associated orbitopathy. [less ▲]

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See detailThe Kozani-Grevena (Greece) earthquake of May 13, 1995, Ms=6.6, Preliminary results of a field multidisciplinary survey
Hatzfeld, D.; Nord, J.; Paul, A. et al

in Seismological Research Letters (1995), 66

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See detailLe rôle de l'industrie de l'assurance dans le pilotage de la sécurité privée et de la politique de prévention
Lemaître, André ULg

in Déviance et Société (1995), 19(N°2), 159-168

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See detailCell surface binding of TIMP-2 and pro-MMP-2/TIMP-2 complex
Emmert-Buck, M. R.; Emonard, H. P.; Corcoran, M. L. et al

in FEBS Letters (1995), 364(1), 28-32

Tissue inhibitor of metalloproteinases (TIMP-2) is a low molecular weight proteinase inhibitor capable of inhibiting activated matrix metalloproteinases (MMPs). TIMP-2 is found both free and in a 1:1 ... [more ▼]

Tissue inhibitor of metalloproteinases (TIMP-2) is a low molecular weight proteinase inhibitor capable of inhibiting activated matrix metalloproteinases (MMPs). TIMP-2 is found both free and in a 1:1 stoichiometric complex with the pro-enzyme form of MMP-2 (pro-MMP-2/TIMP-2 complex). We have measured the binding of recombinant TIMP-2 to intact HT-1080 and MCF-7 cells. HT-1080 cells in suspension bound 125I-labeled rTIMP-2 with a Kd of 2.5 nM and 30,000 sites/cell. Monolayers of MCF-7 cells were similarly found to bind [125I]rTIMP-2 with a Kd of 1.6 nM and 25,000 sites/cell. Specific binding of MMP-2 alone to HT-1080 cells was not observed; however, pro-MMP-2/TIMP-2 complex was capable of binding to the surface of HT-1080 cells in a TIMP-2-dependent manner. Binding of rTIMP-2 was not competed by the presence of TIMP-1. These results suggest that rTIMP-2 alone binds directly to the cell surface of HT-1080 and MCF-7 cell lines, and TIMP-2 is capable of localizing MMP-2 to the surface of HT-1080 cells via interaction with a specific binding site. [less ▲]

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See detailSYNTHESIS OF SIO2-TIO2 XEROGELS BY SOL-GEL PROCESS
Pirson, Anne-Marie ULg; MOHSINE, Abdel; Marchot, Pierre ULg et al

in Journal of Sol-Gel Science and Technology (1995), 4(3), 179-185

A new method to synthesize SiO2-TiO2 gels by sol-gel process has been developed. This technique uses tetraisopropylorthotitanate [Ti(O'Pr)(4)] and tetraethylorthosilicate [TEOS]: they are mixed in the ... [more ▼]

A new method to synthesize SiO2-TiO2 gels by sol-gel process has been developed. This technique uses tetraisopropylorthotitanate [Ti(O'Pr)(4)] and tetraethylorthosilicate [TEOS]: they are mixed in the same solvent and then directly hydrolysed. This one-step reaction is possible because of the use of 2-methoxyethanol, a protic polar solvent. This alcohol plays two different specific roles: it acts as a solvent as well as a stabilizer of titanium alkoxide towards the hydrolysis-precipitation reaction. So, by an accurate adjustment of the quantity of methoxyethanol in the mixture, we can control the reactivity of the titanium precursor. Monolithic and transparent xerogels were obtained whatever the composition. Three monolithic SiO2-TiO2 gels containing 20, 50 and 75 mol% of TiO2 were prepared and studied in details. By using the TG-DSC analysis, we can follow the evolution of the loss of water and organic residues. The structural evolution of gels during calcination is characterized by IR spectroscopy and X-Ray diffraction. [less ▲]

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See detailPersonal name anomia: A single case study
Fery, P.; Vincent, Eric ULg; Brédart, Serge ULg

in Cortex (1995), 31

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See detailL'hyperthyroïdie sévère associée à la prise d'amodarone: une urgence chirurgicale
Meurisse, Michel ULg; Hamoir, Etienne ULg; Joris, Jean ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1995), 36(1), 35-45

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du ... [more ▼]

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du traitement par amiodarone, elles peuvent survenir aussi bien chez des sujets porteurs de thyroïdopathies méconnues ou négligées au moment de l'induction du traitement, que chez des patients apparemment indemnes de toute pathologie thyroïdienne pré-existante. Le traitement médical conservateur est le plus souvent inefficace. Dans ces cas, il convient de poser sans hésitation, l'indication d'une thyroïdectomie la plus radicale possible. Ce rapport traite de l'évolution post-opératoire spectaculaire et favorable de 13 cas consécutifs de thyréotoxicose sévère associée à la prise d'amiodarone. La validité de l'approche chirurgicale repose sur la correction rapide et définitive de l'état toxique après exérèse glandulaire. La morbidité quasi nulle liée au geste chirurgical est la seule alternative thérapeutique antithyroïdienne existante qui permette de poursuivre un traitement par amiodarone lorsque celui-ci est indiqué pour contrôler une arytmie menaçante [less ▲]

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See detailReprésentations de la justice sociale - L'exemple de la Belgique francophone
Jacquemain, Marc ULg

in Année Sociologique (L') (1995), 45

Lorsqu'on analyse les réponses à une batterie de questions sur la justice sociale en Belgique, on voit apparaître trois facteurs, qui ne correspondent pas à des "valeurs" mais plutôt à des "thématiques ... [more ▼]

Lorsqu'on analyse les réponses à une batterie de questions sur la justice sociale en Belgique, on voit apparaître trois facteurs, qui ne correspondent pas à des "valeurs" mais plutôt à des "thématiques transversales". Le premier facteur concerne l'inclusion : la justice est-elle due, par exemple aux immigrés ou aux chômeurs ? Le deuxième facteur concerne le rôle géénral de l'Etat social. Le troisième facteur concerne la dimension première ou subsidiaire de la sécurité sociale. [less ▲]

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See detailA magnetic resonance imaging approach for the diagnosis of a triplet cornual pregnancy.
Bassil, Salim; Gordts, Stéphane; NISOLLE, Michelle ULg et al

in Fertility and Sterility (1995), 64(5), 1029-31

Objectives: To describe a rare case of triplet cornual pregnancy after IVF-ET and to assess the role of magnetic resonance imaging (MRI) for early diagnosis. DESIGN: Case report. SETTING: Infertility and ... [more ▼]

Objectives: To describe a rare case of triplet cornual pregnancy after IVF-ET and to assess the role of magnetic resonance imaging (MRI) for early diagnosis. DESIGN: Case report. SETTING: Infertility and IVF Unit, in an university medical center. PATIENT: A 31-year-old healthy patient with a 3-year history of primary male infertility. INTERVENTION: Standard IVF-ET treatment cycle, using a GnRH-agonist (long protocol) and hMG for ovarian stimulation. RESULTS: A cornual triplet pregnancy is described with the approach for the diagnosis. Magnetic resonance imaging was complementary to endovaginal sonography for early diagnosis and permitted a timed conservative management. CONCLUSIONS: When transvaginal ultrasound findings did not provide an accurate location of the pregnancy, MRI was indicated to confirm the diagnosis. [less ▲]

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See detailA Simple Model for the Fire Resistance of Axially-Loaded Members According to Eurocode 3
Franssen, Jean-Marc ULg; Schleich, Jean-Baptiste; Cajot, Louis-Guy

in Journal of Constructional Steel Research (1995), 35

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental ... [more ▼]

New buckling curves have been developed for axialy loaded steel members subjected to fire. The model is based on extensive numerical simulations calibrated on several dozens of full scale experimental test results. This model has been subsequently included in Eurocode 3. [less ▲]

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See detailHyperfine structure of infrared vanadium lines
Palmeri, P.; Biémont, Emile ULg; Aboussaïd, A. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

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See detailBiologie de la reproduction de deux espèces de Chrysichthys (Siliuriforme, Bagridae) du Lac Nokoué et de la lagune de Porto-Novo au Bénin.
Laleye, P.; Philippart, Jean-Claude ULg; Poncin, Pascal ULg

in Journal of African Zoology = Revue de Zoologie Africaine (1995), 109(3), 213-224

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See detailMaximal cardiac pumping capacity in double-muscled cattle as determined by a pharmacological test
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailBioremediation of diesel-polluted soils.
Jacques, Ph; Bossrez, S.; Mergeay, M. et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103(B46),

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See detailEffect of high osmolarity acclimation on tolerance to hyperosmotic shocks in L929 cultured cells.
Gilles, Raymond ULg; Belkhir, M.; Compère, Philippe ULg et al

in Tissue & Cell (1995), 27(6), 679-687

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin ... [more ▼]

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin. This paper shows that; 1) this phenomenon is concomitant with a complete disappearance of deoxyribonucleic acid, as visualized by immunogold labelling, from the nucleoplasmic spaces; 2) acclimation to high osmolarities (600 mOsm) by addition to the culture medium of NaCl, sorbitol or proline protects the cells from these effects, which appear to be largely attenuated-acclimated cells also survive much better to the osmotic shock than do control cells and; 3) the best protection seems to be provided by sorbitol and NaCl. Proline acclimation is less effective. These effects are discussed in terms of increased tolerance to NaCl load induced at the level of different macromolecules by so-called 'compensatory' organic compounds. [less ▲]

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See detailGrowth hormone, insulin-like growth factor-I and their plasma binding proteins in different cattle breeds.
Renaville, Robert ULg; Massart, Serge; Shojae, D. et al

in Zootecnica e Nutrizione Animale (1995), 21(2),

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See detailLes routes de la foi en pays mosan (IVe-XVe siècles). Sources, méthode et problématique
George, Philippe ULg

in Feuillets de la Cathédrale de Liège (1995)

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See detailIdentification of structural determinants controlling human and mouse stromelysin-3 proteolytic activities
Noël, Agnès ULg; Santavicca, M.; Stoll, I. et al

in Journal of Biological Chemistry (1995), 270

Matrix metalloproteinases (matrixins) constitute a group of extracellular proteinases belonging to the metzincin superfamily. They are involved in both physiological and pathological tissue remodeling ... [more ▼]

Matrix metalloproteinases (matrixins) constitute a group of extracellular proteinases belonging to the metzincin superfamily. They are involved in both physiological and pathological tissue remodeling processes, including those associated with cancer progression. Stromelysin-3, which is expressed in most invasive human carcinomas, is a matrix metalloproteinase with unusual functional properties. In particular, its mature form does not cleave any of the major extracellular matrix components. To define critical structural determinants involved in controlling stromelysin-3 proteolytic activity, we have used site-directed mutagenesis. We show that the deletion of at least 175 C-terminal amino-acids is sufficient to endow mouse stromelysin-3 with activities against casein, laminin, and type IV collagen. In the case of the human enzyme, however, a further and single Ala-235 Pro substitution is necessary to observe similar activities. Ala-235, which characterizes human stromelysin-3 among matrixins, is located immediately after the C terminus of the “Met-turn,” which forms a hydrophobic basis for the catalytic zinc atom in the metzincin family. We conclude that human stromelysin-3 has gained specific functional properties during evolution by amino acid substitution in the catalytic zinc environment, and that it represents an attractive target for specific inhibitors that may be used to prevent cancer progression. [less ▲]

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See detailPulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1995), 42(8), 531-544

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in ... [more ▼]

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies. [less ▲]

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See detailIntragrain pinning strength depth dependence of 2223-(Bi,Pb)-based high critical Tc ceramics made by a vitreous route
Dang, An; Godelaine, P. A.; Vanderbemden, Philippe ULg et al

in Journal of Applied Physics (1995), 77(7), 3560-3562

Campbell's method for measuring the critical current in superconductors has been used to obtain the critical current density and the pinning strength in Bi1.7Pb0.3Sr2Ca2Cu3O10−y ceramics synthesized by a ... [more ▼]

Campbell's method for measuring the critical current in superconductors has been used to obtain the critical current density and the pinning strength in Bi1.7Pb0.3Sr2Ca2Cu3O10−y ceramics synthesized by a vitreous route. The intragrain critical current is much higher than 10^5 A/cm2 at 40 K in zero dc magnetic field. A large increase of the pinning strength is observed near the grain surface. The decrease with depth is hyperbolic. The role of the precursors in the synthesis route is emphasized for introducing specific pinning centers. The analysis takes into consideration the ceramics granular nature, i.e., the existence of intergrain and intragrain currents. ©1995 American Institute of Physics. [less ▲]

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See detailAcquis de la recherche en matière d'évaluation génétique des ovins et des caprins en Tunisie
D'Jemali, M'naouer; Jamal, Sofiene; Ben-Dhiaf, Sonia et al

in Cahiers Options Méditerranéennes (1995), 11

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 ... [more ▼]

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 flocks of Barbary sheep in 1987-92 are presented in 14 tables and discussed. [less ▲]

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See detailAntihyperglycaemic agents. Drug interactions of clinical importance.
Scheen, André ULg; Lefebvre, Pierre ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (1995), 12(1), 32-45

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias ... [more ▼]

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias, coronary insufficiency, heart failure and arthropathies. Thus, polymedication is the rule in this population, and the risk of drug interactions is important, particularly in elderly patients. The present review is restricted to the interactions of other drugs with antihyperglycaemic compounds, and will not consider the mirror image, i.e. the interactions of antihyperglycaemic agents with other drugs. Oral antihyperglycaemic agents include sulphonylureas, biguanides--essentially metformin since the withdrawn of phenformin and buformin--and alpha-glucosidase inhibitors, acarbose being the only representative on the market. These drugs can be used alone or in combination to obtain better metabolic control, sometimes with insulin. Drug interactions with antihyperglycaemic agents can be divided into pharmacokinetic and pharmacodynamic interactions. Most pharmacokinetic studies concern sulphonylureas, whose action may be enhanced by numerous other drugs, thus increasing the risk of hypoglycaemia. Such an effect may result essentially from protein binding displacement, inhibition of hepatic metabolism and reduction of renal clearance. Reduction of the hypoglycaemic activity of sulphonylureas due to pharmacokinetic interactions with other drugs appears to be much less frequent. Drug interactions leading to an increase in plasma metformin concentrations, mainly by reducing the renal excretion or the hepatic metabolism of the biguanide, should be avoided to limit the risk of hyperlactaemia. Owing to its mode of action, pharmacokinetic interferences with acarbose are limited to the gastrointestinal tract, but have not been extensively studied yet. Pharmacodynamic interactions are quite numerous and may result in a potentiation of the hypoglycaemic action or, conversely, in a deterioration of blood glucose control. Such interactions may be observed whatever the type of antidiabetic treatment. They result from the intrinsic properties of the coprescribed drug on insulin secretion and action, or on a key step of carbohydrate metabolism. Finally, a combination of 2 to 3 antihyperglycaemic agents is common for treating patients with NIDDM to benefit from the synergistic effect of compounds acting on different sites of carbohydrate metabolism. Possible pharmacokinetic interactions between alpha-glucosidase inhibitors and classical antidiabetic oral agents should be better studied in the diabetic population. [less ▲]

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See detailBiological-Activity Of Fenoxycarb Against Sitophilus-Zeamais Motsch (Coleoptera, Curculionidae)
Letellier, C.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Journal of Stored Products Research (1995), 31(1),

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See detailRegulation Of The Beta-Lactamase Blal Of Streptomyces-Cacaoi - The Product Of The Blab Regulatory Gene Is An Internal Membrane-Bound Protein
Magdalena, J.; Joris, Bernard ULg; Vanbeeumen, J. et al

in Biochemical Journal (1995), 311

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open ... [more ▼]

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open reading frames, ORF1 (blaA) and ORF2 (blaB) [Lenzini, Magdalena, Fraipont, Joris, Matagne and Dusart (1992) Mol. Gen. Genet. 235, 41-48]. BlaA belongs to the LysR family of transcription activators, whereas BlaB shares some features with the penicillin-recognizing proteins. BlaB has now been overexpressed in Escherichia coli, purified and used for antibody preparation. Immunoblotting of cell-fractionated materials from S. cacaoi showed that BlaB is attached to the internal face of the cytoplasmic membrane. It could not be released by high salt concentrations or EDTA, but only by protease treatment. Under the assay conditions, BlaB did not act as a penicillin-binding protein, a beta-lactamase, a D-amino-peptidase or a target in a phosphorylation step. [less ▲]

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See detailThe Dissociative Ionization of Carbon Dioxide below 21.22 eV. A high Resolution PIPECO spectroscopic investigation.
Locht, Robert ULg

in International Journal of Mass Spectrometry and Ion Processes (1995), 148

The photoion-photoelectron spectrum of O+, CO+ and CO2+ has been investigated under high resolution conditions. The O+ ion production is found not to be restricted to the CO2+ (C2Sigma+/g,0,0,0 ... [more ▼]

The photoion-photoelectron spectrum of O+, CO+ and CO2+ has been investigated under high resolution conditions. The O+ ion production is found not to be restricted to the CO2+ (C2Sigma+/g,0,0,0) predissociation. The (0,1,0) and (1,0,0) levels are clearly shown to be involved. The CO+ ion production involves all the vibrational states reached in the Franck-Condon region, i.e. up to (2,0,1) at 19.94 eV. The CO2+ molecular ion does not survive the predissociation in the entire range covered in the present work. [less ▲]

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See detailCytokines and cartilage degradation
Henrotin, Yves ULg; De Groote, D; Labasse, A et al

in Mediators of Inflammation (1995), 4

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See detailKarel ende Elegast et la tradition folklorique
Varvaro, Alberto; Moreno, Paola ULg

in Moyen Age (Le) (1995), CI(1995), 259-275

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See detailCytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime.
Mathy, Marianne ULg; Deby, Ginette ULg; Deby, C. et al

in Mediators of Inflammation (1995), 4(6), 437-43

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system ... [more ▼]

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system, myeloperoxidase catalyses the conversion of H(2)O(2) and CI(-) to the cytotoxic agent HOCl. Stimulated neutrophils can release MPO into the extracellular environment and then may cause tissue injury through direct endothelial cells lysis. We showed that human umbilical vein endothelial cells (HUVEC) were capable of taking up active MPO. In presence of H(2)O(2) (10(-4) M), this uptake was accompanied by cell lysis. The cytolysis was estimated by the release of (51)Cr from HUVEC and expressed as an index of cytotoxicity (IC). Dose dependent protection was obtained for CAZ concentrations ranging from 10(-5) to 10(-3) M;this can be attributed to inactivation of HOCl by the drug. This protection is comparable to that obtained with methionine and histidine, both of which are known to neutralize HOCl. This protection by CAZ could also be attributed to inactivation of H(2)O(2), but when cytolysis was achieved with H(2)O(2) or O(2) (-) generating enzymatic systems, no protection by CAZ was observed. Moreover, the peroxidation activity of MPO (action on H(2)O(2)) was not affected by CAZ, while CAZ prevented the chlorination activity of MPO (chlorination of monochlorodimedon). So, we concluded that CAZ acts via HOCl inactivation. These antioxidant properties of CAZ may be clinically useful in pathological situations where excessive activation of neutrophils occurs, such as in sepsis. [less ▲]

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See detailprésentation de Abbé Lhomond, De viris (les grands hommes de Rome), Latin/français, traduit et présenté par J. Gaillard, Paris, 1995
Rochette, Bruno ULg

in Bulletin de la Fédération des Professeurs de Grec et de Latin [=FPGL] (1995), 99

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See detailTroubles du rythme et risques somatiques chez le petit enfant
Gauthier, Jean-Marie ULg

in Le temps entre individu et sujet in thérapie psychomotrice et recherches (1995), 102

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See detailEndogenous reproductive hormones and nocturnal rhythms in partner preference and sexual behavior of ATD-treated male rats.
Bakker, Julie ULg; van Ophemert, J.; Timmerman, M. A. et al

in Neuroendocrinology (1995), 62(4), 396-405

Male rats received subcutaneously silastic capsules, containing the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD), shortly after birth. Control males were given silastic capsules containing ... [more ▼]

Male rats received subcutaneously silastic capsules, containing the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD), shortly after birth. Control males were given silastic capsules containing cholesterol. The capsules were removed at the age of 21 days. In adulthood, blood serum was collected early and late in the dark phase of the light/dark cycle (experiment I). Testosterone and luteinizing hormone and follicle stimulating hormone (FSH) fluctuated nocturnally, both in ATD and control males, with highest levels late in the dark phase. FSH levels were significantly higher in ATD males. Nocturnal levels of inhibin, a selective suppressor of pituitary FSH secretion, also fluctuated in both ATD and control males, with lowest levels late in the dark phase. In experiment II, ATD and control males were tested for partner preference behavior in a three-compartment box (choice: sexually active male vs. estrous female) early and late in the dark phase. When gonadally intact, ATD males, but not controls, showed a clear nocturnal rhythmicity in partner preference behavior and sexual behavior. Early in the dark phase, such ATD males preferred the vicinity of and interaction with a sexually active male. Late in the dark phase, this preference for the active male shifted to a preference for the estrous female. Control males preferred the estrous female. After castration and subsequent treatment with testosterone via silastic capsules, which ensured constant blood serum levels, ATD males continued to show their nocturnal rhythms in partner preference behavior and in sexual behavior. Thus, the underlying mechanism of the nocturnal rhythmicity phenomenon is an organizational effect of neonatal ATD treatment rather than an activational effect of fluctuating serum hormone levels. [less ▲]

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See detailPain after laparoscopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine.
Joris, Jean ULg; Thiry, E.; Paris, P. et al

in Anesthesia and Analgesia (1995), 81(2), 379-84

Although pain after laparoscopic cholecystectomy is less intense than after open cholecystectomy, some patients still experience considerable discomfort. Furthermore, the characteristics of ... [more ▼]

Although pain after laparoscopic cholecystectomy is less intense than after open cholecystectomy, some patients still experience considerable discomfort. Furthermore, the characteristics of postlaparoscopy pain differ considerably from those seen after laparotomy. Therefore, we investigated the time course of different pain components after laparoscopic cholecystectomy and the effects of intraperitoneal bupivacaine on these different components. Forty ASA physical status grade I-II patients were randomly assigned to receive either 80 mL of bupivacaine 0.125% with epinephrine 1/200,000 (n = 20) or the same volume of saline (n = 20) instilled under the right hemidiaphragm at the end of surgery. Intensity of total pain, visceral pain, parietal pain, and shoulder pain was assessed 1, 2, 4, 6, 8, 24, and 48 h after surgery. Analgesic consumption was also recorded. Patient data were similar in the two groups. In the saline group, visceral pain was significantly more intense than parietal pain at each time point; visceral and parietal pain were greater than shoulder pain during the first 8 h postoperatively. Intraperitoneal bupivacaine did not significantly affect any of the different components of postoperative pain. Analgesic consumption was similar in the two groups. This study demonstrates that visceral pain accounts for most of the pain experienced after laparoscopic cholecystectomy. Intraperitoneal bupivacaine is not effective for treating any type of pain after laparoscopic cholecystectomy. [less ▲]

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See detailManagement of high turnover osteoporosis with calcitonin
Reginster, Jean-Yves ULg

in Osteoporosis Digest (1995), 3

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See detailRecension de l'ouvrage de Daniel Giovannangeli, "La passion de l'origine"
Steinmetz, Rudy ULg

in Revue Internationale de Philosophie (1995)

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See detailInverse Modulation of Intraepithelial Langerhans' Cells and Stromal Macrophage/Dendrocyte Populations in Human Papillomavirus-Associated Squamous Intraepithelial Lesions of the Cervix
Al-Saleh, Walid; Delvenne, Philippe ULg; Arrese Estrada, Jorge ULg et al

in Virchows Archiv : An International Journal of Pathology (1995), 427(1), 41-8

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal ... [more ▼]

Ninety-four cervical biopsies from normal tissue to high-grade squamous intraepithelial lesion (SILs) were examined for the presence of intraepithelial Langerhans' cells and subpopulations of stromal macrophages/dendrocytes by immunohistochemistry using anti-S100, -L1, -CD68 and -factor XIIIa antibodies. Human papillomavirus (HPV) detection was performed in all cases by using first a mixture of DNA probes for 14 HPV types commonly found in anogenital biopsies at low stringency conditions (Tm -40 degrees C) and by reanalyzing the tissues at high stringency (Tm -10 degrees C) with HPV 6/11, 16/18 and 31/33/35 biotinylated probe cocktails and individual digoxigenin-labelled probes. SILs and metaplastic tissues were significantly associated with a depletion of S100-positive intraepithelial Langerhans' cells when compared with normal epithelium. In contrast, there was a significant increase in L1-positive stromal macrophages in SIL biopsies compared with normal or metaplastic cervix. A significantly higher density of CD68-positive macrophages was also observed in high-grade SILs compared with normal or metaplastic biopsies and with low-grade SILs. The density of factor XIIIa-positive dendrocytes was found to be higher in SILs compared with metaplastic tissues and in high-grade SILs when compared with normal cervical biopsies. No specific relationship was found between the densities of these cells and the HPV type detected in SILs separated into low grade and high grade. The significance of this inverse modulation of intraepithelial Langerhans' cells and stromal macrophages/dendrocytes in normal and SIL biopsies is discussed in relation to HPV infection and malignant transformation. [less ▲]

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