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See detailPostmortem Investigations on Winter Stranded Sperm Whales from the Coasts of Belgium and the Netherlands
Jauniaux, Thierry ULg; Brosens, L.; Jacquinet, E. et al

in Journal of Wildlife Diseases (1998), 34(1), 99-109

During winter 1994-95, four and three sperm whales (Physeter macrocephalus) were stranded along the Belgian and the Dutch coasts, respectively. Necropsies and tissue samplings were collected 24 hrs post ... [more ▼]

During winter 1994-95, four and three sperm whales (Physeter macrocephalus) were stranded along the Belgian and the Dutch coasts, respectively. Necropsies and tissue samplings were collected 24 hrs post mortem. Lesions on several whales included round and linear skin scars, ventral skin abrasions, acute skin ulcers, acute ulcerative stomatitides, acute to chronic external otitides, and passive visceral congestion. In addition, these sperm whales appeared to be debilitated with severe weight deficit, had blubber thickness reduction, the absence of abdominal fat, and the intestinal tracts were almost empty. Three categories of lesions and their possible relation with the stranding were evaluated. Cutaneous scars observed on the seven whales appeared to have no relation with the stranding. The poor body condition and acute integument ulcerative lesions were present before the stranding. Ventral skin abrasions and visceral passive congestion were caused by the strandings. Absence of food in the alimentary tracts, evidence of weight loss and blubber thickness reduction were compatible with an extended presence of the sperm whales in the North Sea, where adequate food is not available. This might lead to progressive weakness, predisposing the animals to secondary pathogens such as viral diseases. Finally, the coastal configuration of the southern North Sea makes it a trap for sperm whales which have entered the area during their wanderings. [less ▲]

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See detailThe recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.
Voz, Marianne ULg; Astrom, A. K.; Kas, K. et al

in Oncogene (1998), 16(11), 1409-16

We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in ... [more ▼]

We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in promoter swapping between the PLAG1 gene, which encodes a novel zinc finger protein, and the constitutively expressed gene for beta-catenin (CTNNB1), a protein with roles in cell-cell adhesion and the WG/WNT signalling pathway. In order to assess the importance of other translocation partner genes of PLAG1, and their possible relationship to CTNNB1, we have characterized a second recurrent translocation, i.e. the t(5;8)(p13;q12). This translocation leads to ectopic expression of a chimeric transcript consisting of sequences from the ubiquitously expressed gene for the leukemia inhibitory factor receptor (LIFR) and PLAG1. As for the t(3;8), the fusions occurred in the 5'-noncoding regions of both genes, exchanging regulatory control elements while preserving the coding sequences. The results of the current as well as previous studies indicate that ectopic expression of PLAG1 under the control of promoters of distinct translocation partner genes is a general pathogenetic mechanism for pleomorphic adenomas with 8q12 aberrations. [less ▲]

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See detailDéveloppement d’un système de séchage contrôlé de faible consommation énergétique à embarquer sur des bateaux de pêche de petites dimensions ou à installer au sol, proche d’une source d’énergie existante
Marchal, Jean ULg; Rodriguez, S.

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (1998), Nouvelle Série 44 (3)(4ème trimestre), 425-443

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See detailLe centre de santé de l’adolescent. I. Justification d’une approche bipolaire et analyse des motifs de consultations
Glowacz, Fabienne ULg; Bourguignon, J.-P.

in Revue Médicale de Liège (1998), 53

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See detailA Novel Bacteriocin With A Ygngv Motif From Vegetable-Associated Enterococcus Mundtii: Full Characterization And Interaction With Target Organisms
Bennik, Mhj.; Vanloo, B.; Brasseur, Robert ULg et al

in Biochimica et Biophysica Acta-Biomembranes (1998), 1373(1), 47-58

A novel broad-spectrum antimicrobial peptide produced by vegetable-associated Enterococcus mundtii was purified and characterized, and designated mundticin. To our knowledge, this is the first report on ... [more ▼]

A novel broad-spectrum antimicrobial peptide produced by vegetable-associated Enterococcus mundtii was purified and characterized, and designated mundticin. To our knowledge, this is the first report on bacteriocin production by this organism. The elucidation of the full primary amino acid sequence of mundticin (KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWSK) revealed that this antimicrobial peptide belongs to the class IIa bacteriocins of lactic acid bacteria which share a highly conserved N-terminal 'YGNGV' motif. Data obtained by computer modelling indicated an oblique orientation of the alpha-helical regions of mundticin and homologous class IIa bacteriocins at a hydrophobic-hydrophilic interface, which may play a role in the destabilization of phospholipid bilayers. The average mass of mundticin, as determined by electron spray mass spectrometry, was found to be 4287.21+/-0.59 Da. With respect to its biological activity, mundticin was shown to inhibit the growth of Listeria monocytogenes, Clostridium botulinum and a variety of lactic acid bacteria. Moreover, it was demonstrated to have a bactericidal effect on L. monocytogenes as a result of the dissipation of the membrane potential, and a loss of intracellular ATP in absence of ATP leakage. Its good solubility in water, and its stability over a wide pH and temperature range indicate the potential of this broad spectrum bacteriocin as a natural preservation agent for foods. [less ▲]

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See detailEffect of Ketoprofen on Paf-Induced Bovine Platelet Aggregation
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Journal (1998), 155(2), 201-203

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See detailL'enseignement en sciences commerciales: les valeurs liées à la relation pédagogique
Robert, Jocelyne ULg

in Education-Formation (1998), 254(Printemps), 15-24

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See detailCompensatory growth in Belgian Blue bulls previously maintained at two growing rates on pasture: animal performance and meat characteristics
Hornick, Jean-Luc ULg; Raskin, Pascale; Clinquart, Antoine ULg et al

in Animal Science (1998), 67(3), 427-434

A comparison was made between finishing systems with Belgian Blue bulls of the double-muscle type, in order to assess the response in terms of compensatory growth when bulls were grazed at a high stocking ... [more ▼]

A comparison was made between finishing systems with Belgian Blue bulls of the double-muscle type, in order to assess the response in terms of compensatory growth when bulls were grazed at a high stocking rate. Two groups of 8 bulls (256.5 kg liveweight) were grazed on Lolium perenne and Trifolium repens pasture during an initial period of 135 days (period I). One group grazed at a stocking rate of 6/ha allowing for normal growth at pasture (NGP); the other group grazed at a stocking rate of 10/ha (low growth at pasture, LGP). Both groups were then finished indoors (period II) with a concentrate based on dried sugarbeet pulp. Eight control bulls were also finished indoors on the concentrate diet during periods I and II (CG). Bulls were slaughtered according to a similar finishing state. Liveweight gains were 1.47, 1.10 and 0.52 kg daily (P<0.001) during period I in CG, NGP and LGP groups respectively. Corresponding liveweight gains during period II were 1.22, 1.37 and 1.50 kg daily. The LGP group had lower feed conversion ratios, slaughter weights (P<0.05) and dressing proportions (P<0.01). The meat from the grazed bulls had lower cooking losses (P<0.05) and tended to have lower drip losses and higher tenderness. It also had a higher cholesterol (P<0.05) content. Large differences were observed in the fatty acid composition according to fat location (subcutaneous, intermuscular or intramuscular). The proportions of mono and polyunsaturated acids increased in the adipose tissue of those previously grazed. [less ▲]

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See detailUrbanisation et consommation d’espace en Belgique. Tendances régionales récentes
Merenne-Schoumaker, Bernadette ULg; Jehin, Jean-Baptiste

in Acta Geographica Lovaniensia (1998), (37), 171-184

The object of this article is to measure the recent evolution of the urban space in Belgium, to show the regional diversity of the process and to seek its main mechanisms. It is based on the cadastral on ... [more ▼]

The object of this article is to measure the recent evolution of the urban space in Belgium, to show the regional diversity of the process and to seek its main mechanisms. It is based on the cadastral on a communal scale. As one could reasonably expect, the Belgian urban space has progressed since 1980, yet at a slower rhythm than during the years 1959-1970. Housing is its main component with over a half of the entire land-use. What growth rate concerns, services (and especially offices) are in the second place while industry ranks to the third position. Regional contrasts generally sharpened. Considering that urbanisation reflects the regional or local dynamism very distinctly, higher values spread out not only in places of suburbanisation and rurbanisation, but also in the developing regions. [less ▲]

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See detailBaudelaire, analyse textuelle : "Les Hiboux"
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1998)

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See detailUne préparation multimédias à affronter les conflits professeur-élèves en classe
Leclercq, Dieudonné ULg; Rommes, O.; Georges, François ULg et al

in Education-Formation (1998), 36130

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See detailZolmitriptan, a 5-HT1B/1D receptor agonist for the acute oral treatment of migraine: a multicentre, dose-range finding study.
Dahlof, C.; Diener, H. C.; Goadsby, P. J. et al

in European Journal of Neurology (1998), 5(6), 535-543

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral ... [more ▼]

Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral migraine therapy. This randomized, placebo-controlled, parallel-group study investigated the efficacy and tolerability of oral zolmitriptan (5, 10, 15 and 20 mg) in the treatment of single acute migraine attacks. Of 1181 patients randomized, 840 were evaluable for the primary efficacy analysis. Headache response rates (a reduction in headache intensity from severe or moderate at baseline to mild or no pain at 2 hours post-treatment) were similar across the zolmitriptan dose groups (66%, 71%, 69% and 77% for 5 mg, 10 mg, 15 mg and 20 mg, respectively) and were significantly higher than that for placebo (19%; all groups P < 0.001). A headache response was reported at 1 hour by 40-50% of zolmitriptan recipients (16% placebo). At 2 hours post dose, 39-47% of zolmitriptan-treated patients were pain-free, compared with 1% of placebo recipients. Headache recurrence occurred in 21-29% (upper 95% CI 37.1) of zolmitriptan-treated patients and in 65% (95% CI 38.3, 85.8) of placebo recipients. Zolmitriptan was well tolerated at each dose. The most commonly reported adverse events were asthenia, dizziness, paraesthesia and feelings of heaviness. Most adverse events were of mild or moderate intensity and were transient. The frequency of adverse events was dose-related. Although, zolmitriptan 5 mg exhibited the most favourable efficacy and tolerability profile, the dose response data suggest that lower doses would also offer significant efficacy. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

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See detailEffect Of Drying On Bioremediation Bacteria Properties
Weekers, F.; Jacques, P.; Springael, D. et al

in Applied Biochemistry and Biotechnology (1998), 70-2

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See detailCurrative radiotherapy for early stage laryngeal carcinoma: results and technical considerations
Ozsahin; Zouhair; Rosset et al

in Radiotherapy & Oncology (1998), 48(Supp1), 27

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See detailEvaluation Of The Genetic Variability Of 23 Bovine Microsatellite Markers In Four Belgian Cattle Breeds
Peelman, Lj.; Mortiaux, F.; Van Zeveren, A. et al

in Animal Genetics (1998), 29(3),

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See detailAnother reason why simple discretizations of rotated diffusion operators cause problems in ocean models: Comments on "Isoneutral diffusion in a z-coordinate ocean model"
Beckers, Jean-Marie ULg; Burchard, H.; Campin, J. M. et al

in Journal of Physical Oceanography (1998), 28(7), 1552-1559

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on ... [more ▼]

A method to improve the behavior of the numerical discretization of a rotated diffusion operator such as, for example, the isopycnal diffusion parameterization used in large-scale ocean models based on the so-called z-coordinate system is presented. The authors then focus exclusively on the dynamically passive tracers and analyze some different approaches to the numerical discretization. Monotonic schemes are designed but are found to be rather complex, while simpler, linear schemes are shown to produce unphysical undershooting and vershooting. It is suggested that the choice of an appropriate discretization method depends on the importance of the rotated diffusion in a given simulation, whether the field to be diffused is dynamically active or not. [less ▲]

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See detailL'arbre que cache la forêt
Duchesne, Jean-Patrick ULg

in Art&fact (1998), 17

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See detailSelf-consistent approximations in relativistic plasmas: Quasiparticle analysis of the thermodynamic properties
Vanderheyden, Benoît ULg; Baym, G.

in Journal of Statistical Physics (1998), 93(3-4), 843-861

We generalize the concept of conserving, Phi-derivable, approximations to relativistic field theories. Treating the interaction field as a dynamical degree of freedom, we derive the thermodynamic ... [more ▼]

We generalize the concept of conserving, Phi-derivable, approximations to relativistic field theories. Treating the interaction field as a dynamical degree of freedom, we derive the thermodynamic potential in terms of fully dressed propagators, an approach which allows us to resolve the entropy of a relativistic plasma into contributions from its interacting elementary excitations. We illustrate the derivation for a hot relativistic system governed by electromagnetic interactions. [less ▲]

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See detailPharma clinics. Comment je traite ... un patient diabetique avec obesite severe.
Scheen, André ULg; Triches, K.; Luyckx, Françoise ULg et al

in Revue Médicale de Liège (1998), 53(7), 386-9

Obesity plays a crucial role in type 2 diabetes pathophysiology and a major weight loss markedly improves glycaemic control. The common failure of classical treatments leads to the use of more aggressive ... [more ▼]

Obesity plays a crucial role in type 2 diabetes pathophysiology and a major weight loss markedly improves glycaemic control. The common failure of classical treatments leads to the use of more aggressive weight-reduction approaches, such as very-low-calorie diets (VLCDs), anti-obesity drugs or even bariatric surgery. VLCDs are very successful in the short-term but rather disappointing in the long-term. Anti-obesity compounds only induce a modest mean weight reduction, even if some patients appear to be better responders. Interestingly, serotoninergic agents increase insulin sensitivity and glycaemic control, independently of weight loss. Bariatric surgery provides the most impressive results. In well-selected subjects, gastroplasty (either vertical ring gastroplasty or adjustable silicone gastric banding) generally induces a considerable weight loss which results in a remarkable and sustained glycaemic control improvement and allows the reduction, or even the suppression, of any antidiabetic treatment. This ultimate solution should not be neglected after failure of medical approaches, provided that the indication is correct, the surgical procedure is performed in a specialized centre and the followup is well organized by a multidisciplinary team. [less ▲]

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See detailRadiotherapy of choroidal metastases.
Rosset, A; Zografos, L; COUCKE, Philippe ULg et al

in Radiotherapy & Oncology (1998), 46(3), 263-268

Abstract Purpose: This retrospective study was undertaken to clarify the role of high energy external beam radiation therapy (EBRT) and to determine its safety and efficacy on local control and visual ... [more ▼]

Abstract Purpose: This retrospective study was undertaken to clarify the role of high energy external beam radiation therapy (EBRT) and to determine its safety and efficacy on local control and visual acuity in patients suffering from choroidal metastases (CM). Materials and methods: The records of 58 consecutive patients treated with EBRT between 1970 and 1993 were analyzed. The female to male ratio was 2.9 and the median age was 59 years (range 40–81 years). Thirty-six patients (62%) had unilateral CM and 22 patients had bilateral CM. The mean number of lesions per eye was two. Retinal detachment was present in 65% of cases. The primary tumour (PT) was breast carcinoma for 38 patients (75%), lung carcinoma for 10 patients (17%) and gastrointestinal, genitourinary or unknown PT for the remaining 10 patients. The median interval of time between the PT and the CM was 55 months (range 0–228 months). All patients were treated with megavoltage irradiation. The median prescribed dose was 35.5 Gy (range 20–53 Gy) normalized at a 2 Gy per fraction schedule with an a/b value of 10 Gy. Various techniques were used and whenever possible the lens was spared. Ten patients with unilateral disease were treated in both eyes. Results: The tumour response was slow. When assessed after 3 months or more, the complete response rate was 53% with significantly better results for doses higher than 35.5 Gy (72 versus 33%; P = 0.009). Visual acuity was improved or stabilized in 62% of patients, with also significantly better results when doses higher than 35.5 Gy (P = 0.014) were administered. Amongst 26 patients with unilateral CM who had no elective contralateral irradiation, three developed metastasis in the opposite eye versus none of the 10 patients who had bilateral irradiation. Five complications occurred (three cataracts, one retinopathy and one glaucoma). Conclusion: Radiation therapy is an efficient and safe palliative treatment for choroidal metastases and it helps the preservation of vision. Thus, there is a major impact on the quality of life in a group of patients with an almost uniformly fatal prognosis. Both tumour response and visual acuity are significantly improved if doses higher than 35.5 Gy are administered. Whenever possible, a lens sparing technique should be used. Ó 1998 Elsevier Science Ireland Ltd. [less ▲]

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See detailActualites therapeutiques 1997-1998 (1). Premiere partie.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(8), 459-66

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be stressed. This first part is devoted to drugs acting on cardiovascular, respiratory, digestive and neurologic diseases. [less ▲]

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See detailFacilitatory effects of chronically administered citicoline on learning and memory processes in the dog.
Bruhwyler, J.; Liégeois, Jean-François ULg; Geczy, J.

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (1998), 22(1), 115-28

1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment ... [more ▼]

1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment. 2. This study aimed to evaluate the effects of citicoline on learning and retrieval processes in a complex differential reinforcement of response duration schedule in normal dogs. 3. The effects of citicoline on a stabilized performance were also measured in order to be able to differentiate specific memory effects from non specific influences on the motor, neuro-vegetative and motivational systems. 4. The results demonstrate that citicoline can exert facilitatory effects on learning and memory but also on retrieval processes. The complete absence of effects on the stabilized performance and on the motor, neuro-vegetative and motivational systems constitutes arguments in favour of a selectivity of action on the memory processes. [less ▲]

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See detailLe cas clinique du mois. Une nephropathie galopante chez un patient diabetique de type 2.
Philips, Jean-Christophe ULg; Scheen, André ULg; Firre, E. et al

in Revue Médicale de Liège (1998), 53(4), 171-4

We report the case of a patient with insulin-requiring type 2 diabetes who exhibited a rapid deterioration of his renal function leading to haemodialysis in a few months. Various diagnosis were considered ... [more ▼]

We report the case of a patient with insulin-requiring type 2 diabetes who exhibited a rapid deterioration of his renal function leading to haemodialysis in a few months. Various diagnosis were considered to explain this rapid deterioration, excluding diabetic nephropathy as major etiology. The exploration, especially renal biopsy, demonstrated the presence of a glomerulonephritis due to the deposition of immune complexes associated to active hepatitis C rather than diabetic glomerulosclerosis. A treatment with interferon-alpha allowed to partially restore renal function, this recovery permitting the interruption of hemodialysis, with a current follow-up of more than 6 months. [less ▲]

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See detailStudy of siliceous karst genesis in Eastern Niger. Microscopy and analysis of speleothems
Willems, Luc ULg; Compère, Philippe ULg; Sponholz, Barbara

in Zeitschrift für Geomorphologie (1998), 42(2), 129-142

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See detailHematopoietic recovery in cancer patients after transplantation of autologous peripheral blood CD34+ cells or unmanipulated peripheral blood stem and progenitor cells.
Beguin, Yves ULg; Baudoux, Etienne ULg; Sautois, Brieuc ULg et al

in Transfusion (1998), 38(2), 199-208

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS ... [more ▼]

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS: Peripheral blood stem and progenitor cells (PBPCs) were collected from 32 patients, and 17 CD34+ cell-selection procedures were carried out in 15 of the 32. One patient in whom two procedures failed to provide 1 x 10(6) CD34+ cells per kg was excluded from further analysis. After conditioning, patients received CD34+ cells (n = 10, CD34 group) or unmanipulated (n = 17, PBPC group) PBPCs containing equivalent amounts of CD34+ cells or progenitors. RESULTS: The yield of CD34+ cells was 53 percent (18-100) with a purity of 63 percent (49-82). The CD34+ fraction contained 66 percent of colony-forming units--granulocyte-macrophage (CFU-GM) and 58 percent of CFU of mixed lineages, but only 33 percent of burst-forming units-erythroid (BFU-E) (p < 0.05). Early recovery of neutrophils and reticulocytes was identical in the two groups, although a slight delay in platelet recovery may be seen with CD34+ cell selection. Late hematopoietic reconstitution, up to 1.5 years after transplant, was also similar. The two groups were thus combined for analyses of dose effects. A dose of 40 x 10(4) CFU-GM per kg ensured recovery of neutrophils to a level of 1 x 10(9) per L within 11 days, 15 x 10(4) CFU of mixed lineages per kg was associated with platelet independence within 11 days, and 100 x 10(4) BFU-E per kg predicted red cell independence within 13 days. However, a continuous effect of cell dose well beyond these thresholds was apparent, at least for neutrophil recovery. CONCLUSION: CD34+ cell selection, despite lower efficiency in collecting BFU-E, provides a suitable graft with hematopoietic capacity comparable to that of unmanipulated PBPCs. In both groups, all patients will eventually show hematopoietic recovery of all three lineages with 1 x 10(6) CD34+ cells per kg or 5 x 10(4) CFU-GM per kg, but a dose of 5 x 10(6) CD34+ cells or 40 x 10(4) CFU-GM per kg is critical to ensure rapid recovery. [less ▲]

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See detailScintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial.
Palmedo, H.; Biersack, H. J.; Lastoria, S. et al

in European Journal of Nuclear Medicine (1998), 25(4), 375-85

The aim of the trial was to determine the diagnostic accuracy of scintimmammography with technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) in the detection of primary breast cancer and to verify its ... [more ▼]

The aim of the trial was to determine the diagnostic accuracy of scintimmammography with technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) in the detection of primary breast cancer and to verify its clinical usefulness. A total of 246 patients with a suspicious breast mass or positive mammogram were included in this prospective European multicentre trial. At 5 min and 60 min (optional) p.i. two lateral prone images were acquired for 10 min each; 30 min p.i. one anterior image was acquired for 10 min. There were 253 lesions (195 palpable and 58 non-palpable), in respect of which histology revealed 165 cancers and 88 benign lesions. Institutional and blinded read results were correlated to core laboratory histopathology results obtained during excisional biopsy. Diagnostic accuracy for the detection of breast cancer was calculated per lesion. The overall sensitivity and specificity of blinded read scintimammography were 71% and 69%, respectively. For palpable lesions, the sensitivity of blinded read and institutional read scintimammography was 83% and 91%, respectively. Sensitivity was not dependent on the density of the breast tissue. Invasive ductal and invasive lobular cancers showed similar sensitivity. The sensitivity and specificity of mammography were 91% and 42%, respectively, and did not depend on the tumour size. In 60% of false-negative mammograms, 99mTc-MIBI was able to diagnose malignancy (true-positive). High-quality imaging with 99mTc-MIBI has a high diagnostic accuracy for the detection of primary breast cancer. Used as a complementary method, scintimammography with 99mTc-MIBI can help to diagnose breast cancer at an earlier stage in patients with dense breasts. [less ▲]

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See detailBonding electropolymerization: a new electron-transfer strategy for the tailoring of performant polymer-based composites
Baute, Noëlle; Calberg, Cédric ULg; Dubois, Philippe ULg et al

in Macromolecular Symposia (1998), 134

Careful control of experimental conditions in the cathodic electropolymerization of acrylonitrile allows the grafting of thin polymer films, on conducting surfaces offering electrons easily mobilized at a ... [more ▼]

Careful control of experimental conditions in the cathodic electropolymerization of acrylonitrile allows the grafting of thin polymer films, on conducting surfaces offering electrons easily mobilized at a relatively low potential. Matching relative polarity and donicity of solvent and monomer expands the applicability of this methodology to the whole class of (meth)acrylic monomers, paving the way to many new and useful multiphase materials. [less ▲]

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See detailAssessment of proliferative and colony-forming capacity after successive in vitro divisions of single human CD34+ cells initially isolated in G0.
GOTHOT, André ULg; Pyatt, R.; McMahel, J. et al

in Experimental hematology (1998), 26(7), 562-70

Exit of primitive hematopoietic progenitor cells (HPCs) from the G0 phase of the cell cycle in response to in vitro cytokine stimulation is a limiting step in successful ex vivo expansion. Simultaneous ... [more ▼]

Exit of primitive hematopoietic progenitor cells (HPCs) from the G0 phase of the cell cycle in response to in vitro cytokine stimulation is a limiting step in successful ex vivo expansion. Simultaneous DNA/RNA staining with Hoechst 33342 and pyronin Y was used to separate human bone marrow CD34+ cells residing in G0 (G0CD34+) from those cycling in G1 and S/G2+M. Compared with CD34+ cells isolated in G1, G0CD34+ cells were characterized by a delayed response to cytokine stimulation and were enriched for long-term hematopoietic culture-initiating cells. We next compared the activation kinetics of individually sorted G0CD34+ cells stimulated with stem cell factor (SCF), flt3-ligand (FL), or interleukin-3 (IL-3) as single factors. In a novel clonal proliferation assay, the functional status of cells that had remained quiescent after an initial 7-day period and of those that had completed successive division cycles under each of these three factors was evaluated by assessment of subsequent proliferative capacity and maintenance of colony-forming cell precursor (pre-CFC) activity. All three cytokines were equally able to support the survival of primitive HPCs in the absence of cell division. Cells that did not respond to any cytokine stimulation for 7 days retained higher proliferative and pre-CFC activities than dividing cells. The hematopoietic function of cells that divided in response to SCF, FL, or IL-3 decreased after each division cycle. However, G0CD34+ cells displayed a heterogeneous response pattern to cytokine stimulation whereby SCF appeared to have a superior ability to promote the cycling of cells with high proliferative and pre-CFC activities. These results indicate that HPCs reside in opposing hierarchies of hematopoietic potential and responsiveness to cytokine stimulation. The data also begin to indicate relationships between cellular division in response to different stimuli and maintenance of hematopoietic function. [less ▲]

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See detailOral antidiabetic agents. A guide to selection.
Scheen, André ULg; Lefebvre, Pierre ULg

in Drugs (1998), 55(2), 225-36

Type 2 diabetes mellitus (formerly named non-insulin-dependent diabetes mellitus or NIDDM) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin ... [more ▼]

Type 2 diabetes mellitus (formerly named non-insulin-dependent diabetes mellitus or NIDDM) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. Various pharmacological approaches can be used to improve glucose homeostasis via different modes of action: sulphonylureas essentially stimulate insulin secretion, biguanides (metformin) act by promoting glucose utilisation and reducing hepatic-glucose production, alpha-glucosidase inhibitors (acarbose) slow down carbohydrate absorption from the gut and thiazolidinediones (troglitazone) enhance cellular insulin action on glucose and lipid metabolism. These pharmacological treatments may be used individually for certain types of patients, or may be combined in a stepwise fashion to provide more ideal glycaemic control for most patients. Selection of oral antihyperglycaemic agents as first-line drug or combined therapy should be based on both the pharmacological properties of the compounds (efficacy and safety, profile) and the clinical characteristics of the patient (stage of disease, bodyweight, etc.). Mildly hyperglycaemic patients should preferably be treated with metformin, acarbose or thiazolidinediones (which are not associated with any hypoglycaemic risk), while more severely hyperglycaemic individuals should receive a sulphonylurea. In moderately hyperglycaemic patients, sulphonylureas should be preferred in nonobese patients while metformin, and probably also thiazolidinediones, should have priority in obese insulin-resistant type 2 diabetic patients. Acarbose is mainly indicated to reduce post-prandial glucose fluctuations and improve glycaemic stability. Each antihyperglycaemic agent may also be combined with insulin therapy to improve glycaemic control and/or reduce the insulin requirement of diabetic patients after secondary failure to oral treatment. Finally, safety should be taken into account in elderly patients and/or those with renal impairment, especially as far as the use of sulphonylureas (higher risk of hypoglycaemia) and metformin (higher risk of lactic acidosis) is concerned. [less ▲]

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See detailReducing properties, and markers of lipid peroxidation in normal and hyperhydrating shoots of Prunus avium L.
Franck, Thierry ULg; Kevers, Claire ULg; Penel, Claude et al

in Journal of Plant Physiology (1998), 153(3-4), 339-346

The amounts of some reductants (ascorbic acid, reduced glutathione, cx-tocopherol) and the amounts of some markers of lipid peroxidation (peroxide and malondialdehyde) were quantified weekly in normal ... [more ▼]

The amounts of some reductants (ascorbic acid, reduced glutathione, cx-tocopherol) and the amounts of some markers of lipid peroxidation (peroxide and malondialdehyde) were quantified weekly in normal shoots (NS, in culture on agar) and in hyperhydrating shoots (HS, in culture on gelrite) of Prunus avium L. The redox activity of the plasma membrane (reduction of exogenously added ferricyanide), the antilipoperoxidant potential, the level of hydrogen peroxide and the lipoxygenase (EC 1.13.11.12) activity were investigated after 28 days of culture in both types of shoots. Reducing capacity of HS seemed generally more efficient in comparison to NS: higher levels of free ascorbate, reduced glutathione and the antilipoperoxidant potential were measured in HS than in NS. The alpha-tocopherol content did not change between the two types of shoots Reduction of exogenously applied ferricyanide was lower in HS during the last 2 weeks of the culture. These results suggest that the plasma membrane of HS had an unchanged reducing capacity but less redox transfer activity in comparison to NS. Markers of membrane damage (peroxide and malondialdehyde) were lower in HS than in NS and the same level of hydrogen peroxide was measured in the two types of shoots. Therefore, HS seem not to be submitted to oxidative stress. However, a more important lipoxygenase activity measured in HS was in contradiction to the lower peroxidation of lipids. The discussion points out some paradoxical results in an extensive classical analysis of stress criteria and indicates alternative defense mechanisms. [less ▲]

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See detailClinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials.
Scheen, André ULg

in Diabètes & Métabolism (1998), 24(4), 311-20

Acarbose, an alpha-glucosidase inhibitor, is a new antihyperglycaemic agent which has been proposed as add-on therapy in Type 2 diabetic patients not well-controlled with diet alone, sulphonylurea ... [more ▼]

Acarbose, an alpha-glucosidase inhibitor, is a new antihyperglycaemic agent which has been proposed as add-on therapy in Type 2 diabetic patients not well-controlled with diet alone, sulphonylurea, metformin or insulin, and in Type 1 diabetic patients with large meal-related plasma glucose excursions. Numerous controlled studies investigating the clinical effects of acarbose in Type 2 diabetes versus either placebo or, more rarely, versus a reference drug (sulphonylurea or metformin) have been published during the last 10 years. All placebo-controlled studies have demonstrated the superiority of acarbose, at a dose of 150-600 mg/day, in decreasing fasting and postprandial glucose levels as well as HbA1c concentrations (mean decrease of 0.7%), whether acarbose was given as first-line therapy in diet-treated diabetic patients or in combination in individuals already receiving a sulphonylurea, metformin or insulin. Only a few controlled studies have compared the effects of acarbose with those of either sulphonylurea or metformin, yielding controversial results. In Type 1 diabetic patients, a small reduction of HbA1c levels was also reported after addition of acarbose to insulin therapy, which in some cases allowed a slight reduction of daily insulin needs. All these favourable biological effects occurred without exposing the patient to hypoglycaemia or weight gain. A few studies have also reported favourable effects on postprandial lipid profile and some other vascular risk factors. However, it is not clear whether the extra cost of acarbose, when compared to that of older oral antidiabetic agents, is justified since no study has yet demonstrated its potential benefit on the complications and long-term prognosis of diabetic patients. [less ▲]

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See detailAltered apoptotic profiles in irradiated patients with increased toxicity
Ozsahin, Mahmut; Miralbell, Raymond; Emery, Gillian et al

in International Journal of Radiation, Oncology, Biology, Physics (1998), 42(Supplément), 135

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See detailLa chirurgie sous hypnosedation. Une nouvelle approche therapeutique pour l'hyperparathyroidie.
Defechereux, Thierry ULg; Faymonville, Marie ULg; Joris, Jean ULg et al

in Annales de Chirurgie (1998), 52(5), 439-43

The elective unilateral approach, sometimes under local anaesthesia, offers many advantages in terms of less invasive and faster surgical approach compared to the conventional surgery under general ... [more ▼]

The elective unilateral approach, sometimes under local anaesthesia, offers many advantages in terms of less invasive and faster surgical approach compared to the conventional surgery under general anaesthesia. Nevertheless this approach is restricted to patients unsuspected of multiglandular disease, free from thyroid disease and for whom localization studies are contributive. Surgery under hypnosedation offers the same advantages and provides the possibility of not only exploring the four glands but also of performing a partial thyroidectomy if needed. In our experience 21 patients underwent a cervicotomy under hypnosedation for primary hyperparathyroidism (HPT). No conversion to general anaesthesia was needed; mean operative time was 52 +/- 16 min. In 17 cases, HPT was due to a single adenoma, in 3 cases to hyperplasia (among them a MEN-1 case), and in one last case to a double adenoma. The four glands were identified in 85%. With a follow-up running from 4 to 45 months, all patients are cured. Hypnosedation offers the same medical and economic advantages than the unilateral access under local anaesthesia. Moreover indications are not restricted to selected patients. [less ▲]

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See detailExpression of Growth Hormone Receptors by Lymphocyte Subpopulations in the Human Tonsil
Thellin, Olivier ULg; Coumans, Bernard ULg; Zorzi, Willy ULg et al

in Developmental Immunology (1998), 6(3-4), 295-304

The ability of human tonsillar lymphoid cells to express growth hormone receptor (hGH-N-R) was analyzed by flow cytometry. FITC-coupled recombinant human growth hormone (hGH-N) was used to reveal the ... [more ▼]

The ability of human tonsillar lymphoid cells to express growth hormone receptor (hGH-N-R) was analyzed by flow cytometry. FITC-coupled recombinant human growth hormone (hGH-N) was used to reveal the receptors, in combination with phenotype markers. Unlike T cells, tonsillar B cells constitutively express the hGH-N receptor. Quiescent cells separated from activated cells by Percoll-gradient centrifugation bear fewer receptors than activated ones. Activated T cells express hGH-N-R, but the typical germinal centre CD4+ CD57+ T cells do not. These latter thus appear not to be fully activated. Inside the lymph follicles, the germinal centre CD38+ B-cell population and the mantle-zone CD39+ B-cell population display similar levels of hGH-N-R expression, but receptor density is lower on dividing dark-zone CD38+ CD10+ B cells. Different lymphoid-cell populations thus differ markedly in their ability to express the growth hormone receptor, in relation notably to their activation status. This highlights the link between the neuroendocrine system and the active immune defense. [less ▲]

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See detailLes karsts siliceux d'Afrique
Vicat, Jean-Paul; Willems, Luc ULg

in Géosciences au Cameroun @ collection Géocam (1998), 1

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See detailUltrastructural nucleolar alterations induced by an ametantrone--poly r(A-U) complex.
Jamison, J. M.; Gilloteaux, J.; Thiry, Marc ULg et al

in Tissue & Cell (1998), 30(4), 475-84

The current study has documented changes in the ultrastructure as well as in the intranucleolar distribution of rDNA and rRNA in RT4 (human transitional cell bladder carcinoma) cell nucleoli following a 3 ... [more ▼]

The current study has documented changes in the ultrastructure as well as in the intranucleolar distribution of rDNA and rRNA in RT4 (human transitional cell bladder carcinoma) cell nucleoli following a 3-h exposure to toxic doses of 50 microM ametantrone (AMT), 200 microM poly (adenylate-uridylate) (poly r(A-U) or an AMT/poly r(A-U) combination with an AMT/polyribonucleotide ratio of 1:4 and a poly r(A-U) concentration of 200 microM. While the main nucleolar components (fibrillar center (F), dense fibrillar component (D), granular component (G) and interstices (I) can be discerned following all treatments, the nucleoli exhibit: compaction, segregation, a decrease in the number of F, an increase in the size of remaining F, margination of intranucleolar chromatin and retention of intranucleolar pre-rRNA and rRNA. The relative abilities of the test agents to induce nucleolar compaction are AMT/poly r(A-U) > poly r(A-U) > AMT > sham-treated, while the abilities of the test agents to induce the remaining nucleolar changes are AMT/poly r(A-U) > or = AMT > poly r(A-U) > sham-treated cells. Poly r(A-U) and the induced interferon induce nucleolar compaction, while AMT produces nucleolar segregation. These results are consistent with a model in which the poly r(A-U) and/or the AMT inhibit DNA transcription and rRNA processing as well as the release of nascent preribosomes from the nucleolus. [less ▲]

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See detailThe Pathophysiology of Migraine: A Review Based on the Literature and on Personal Contributions
Schoenen, Jean ULg

in Functional Neurology (1998), 13(1, Jan-Mar), 7-15

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See detailStructured imagination of novel creatures' faces
Brédart, Serge ULg; Ward, T. B.; Marczewski, P.

in American Journal of Psychology (The) (1998), 111(4), 607-625

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See detailVector mesons from tensor couplings in the NJL model
Jaminon, Martine ULg; Ruiz Arriola, Enrique

in Physics Letters B (1998), 443

We propose to describe vector mesons in a pure quark model such as the one of Nambu and Jona-Lasinio by means of four point tensor interactions, but with vanishing vector and axial couplings. This becomes ... [more ▼]

We propose to describe vector mesons in a pure quark model such as the one of Nambu and Jona-Lasinio by means of four point tensor interactions, but with vanishing vector and axial couplings. This becomes possible due to tensor-vector mixing at the one quark loop level. As a consequence a bound particle with rho quantum numbers is generated. This has the advantage of avoiding the A-pi mixing which is known to generate a wrong off-shell pion wave function renormalization. In addition, there is no A1 meson. We make our arguments quantitative by computing Euclidean correlators via dispersion relations and comparing with lattice QCD and random instanton model results. [less ▲]

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See detailEffects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes.
Henrotin, Yves ULg; Labasse, A. H.; Jaspar, J. M. et al

in Clinical Rheumatology (1998), 17(1), 31-9

The in-vitro effects of avocado and soybean unsaponifiable residues on neutral metalloproteinase activity, cytokines and prostaglandin E2 (PGE2) production by human articular chondrocytes were ... [more ▼]

The in-vitro effects of avocado and soybean unsaponifiable residues on neutral metalloproteinase activity, cytokines and prostaglandin E2 (PGE2) production by human articular chondrocytes were investigated. Avocado and soybean unsaponifiable residues were mixed in three ratios: 1:2 (A1S2), 2:1 (A2S1) or 1:1 (A2S2). Freshly isolated human chondrocytes were cultured for 72 h in the absence or presence of interleukin-1beta, (IL-1beta) (17 ng/ml), with or without unsaponifiable residue mixtures at a concentration of 10 microg/ml. A/S unsaponifiable residues were also tested separately at concentrations of 3.3, 6.6 and 10 microg/ml. All A/S unsaponifiable mixtures reduced the spontaneous production of stromelysin, interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E2 (PGE2) by chrondrocytes. At concentrations of 3.3 and 6.6 microg/ml, A/S residues, tested separately, were potent inhibitors of the production of IL-8 and PGE2. Nevertheless, only avocado residue inhibited IL-6 production at these concentrations. A/S unsaponifiable mixtures had a more pronounced inhibitory effect on cytokine production than avocado or soybean residues added alone. As anticipated, IL-1beta induced a marked release of collagenase, stromelysin, IL-6, IL-8 and PGE2. A/S unsaponifiable mixtures partially reversed the IL-1 effects on chrondrocytes. These findings suggest a potential role for A/S unsaponifiable extracts in mitigating the deleterious effects of IL-1beta: on cartilage. [less ▲]

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See detailThe effect of BaZrO3 addition on transport properties of Dy-based 123-211 composite materials: electrical resistivity, thermal conductivity and thermoelectric power
Bougrine, Hassan ULg; Ausloos, Marcel ULg; Pekala, M. et al

in Superconductor Science & Technology (1998), 11(8), 803-809

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power ... [more ▼]

Composite samples made of 123-211 DyBaCuO-based systems with 1, 4, 10 and 15% in weight BaZrO3 additions have been synthesized. Their electrical resistivity, thermal conductivity and thermoelectric power have been measured. The electrical resistivity has also been measured in a magnetic field less than 1 T. The data show that BaZrO3 addition has a non-trivial effect: beside mildly reducing the critical temperature of the superconductor, it increases the scattering at small concentration, and effectively reduces weak link features in the electrical property, but increases the thermal conductivity. The field influence on T-c is shown to be T-c(O)- T-c(B) approximate to B-1/2. [less ▲]

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See detailL'assistance cardiaque par muscle strie squelettique transforme: la cardiomyoplastie
RADERMECKER, Marc ULg; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1998), 53(2), 88-90

The biomechanical potential of transformed skeletal muscle used for cardiocirculatory assistance is the keystone of this surgical concept. This underscores the necessity to modulate type II to type I ... [more ▼]

The biomechanical potential of transformed skeletal muscle used for cardiocirculatory assistance is the keystone of this surgical concept. This underscores the necessity to modulate type II to type I transformation to premise the muscle bulk, shortening velocity, and, therefore, power. It is only if an efficient autologous engine is available that optimal surgical configuration (i.e. aortomyoplasty) will provide active cardiocirculatory support. [less ▲]

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See detailReciprocal regulation of protein tyrosine kinases p56lck and p59fyn, and altered tyrosine phosphorylation in murine AIDS.
Trebak, Mohamed; Lambert, Chantal ULg; Rahmouni, Souad ULg et al

in International Immunology (1998), 10(10), 1473-80

Murine AIDS (MAIDS), caused by a defective murine leukemia virus, is a severe lymphoproliferative disease associated with profound immunodeficiency and increased susceptibility to opportunistic infections ... [more ▼]

Murine AIDS (MAIDS), caused by a defective murine leukemia virus, is a severe lymphoproliferative disease associated with profound immunodeficiency and increased susceptibility to opportunistic infections. Most subsets of lymphocytes, including CD4+ and CD8+ T cells, are refractory to mitogen stimulation. As a first step to examine proximal signal transduction in the infected mice, Western and Northern blot analyses were performed, and showed that p56lck is dramatically decreased at the protein as well as the mRNA level in the lymph nodes (LN). In contrast, p59(fyn) and its mRNA were slightly increased in the LN of the same mice. Similar results were obtained with purified T cells. Interestingly, the thymus of the infected animals did not show any abnormality regarding p56(lck) or p59(fyn). Tyrosine phosphorylation was constitutively increased in the infected mice and was barely amplified by anti-CD3 mAb stimulation. A similar pattern was observed when tyrosine phosphorylation was selectively examined at the level of ZAP-70. Our results suggest that a reciprocal regulation of p56(lck) and p59(fyn) protein tyrosine kinases, previously described in various models of anergy, could also be involved in the pathogenesis of MAIDS. [less ▲]

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See detailDevelopment of an in vitro culture techniques adapted to Phaseolus polyanthus and P. vulgaris embryos.
Geerts, P.; Baudoin, Jean-Pierre ULg; Mergeai, Guy ULg

in Bean Improvement Cooperative (1998), 41

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See detailThe tridimensional personality questionnaire (TPQ) and depression.
Hansenne, Michel ULg; Pitchot, William ULg; Gonzalez Moreno, A. et al

in European Psychiatry (1998), 13(2), 101-3

The relationships between the Tridimensional Personality Questionnaire (TPQ) and depression were examined in a sample of 53 major depressive patients and 33 healthy controls. Depressed patients exhibit ... [more ▼]

The relationships between the Tridimensional Personality Questionnaire (TPQ) and depression were examined in a sample of 53 major depressive patients and 33 healthy controls. Depressed patients exhibit higher harm avoidance scores as well as lower novelty seeking sub-scale exploratory excitability (NS1) scores as compared to healthy controls. However, the other dimensions and their sub-scales do not differ between depressive patients and controls. In the depressive group, the harm avoidance dimension is related to the severity of depression as assessed by the Hamilton scale. This study confirms the state dependence of the harm avoidance dimension and suggests a relationship between the novelty seeking sub-scale NS1 and depression. [less ▲]

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See detailRoutine ultrasound screening for abdominal aortic aneurysm among 65- and 75-year-old men in a city of 200,000 inhabitants.
Vazquez, C.; SakalihasanN, Natzi ULg; D'Harcour, J. B. et al

in Annals of Vascular Surgery (1998), 12(6), 544-9

Unruptured abdominal aortic aneurysm (AAA) is seldom recognized. Thus it is difficult to know whether the incidence of AAA in the general population is high enough to warrant routine screening at least in ... [more ▼]

Unruptured abdominal aortic aneurysm (AAA) is seldom recognized. Thus it is difficult to know whether the incidence of AAA in the general population is high enough to warrant routine screening at least in men after a certain age. Ultrasound screening studies to evaluate the incidence of AAA have been carried out in several English-speaking and Scandinavian countries. The purpose of this report is to describe the results of a study carried out in Belgium. All 65- and 75-year-old men living in the city of Liege, Belgium, were given the opportunity to undergo a free ultrasound examination. Only 41% of the target population was examined. AAA defined as abdominal aortic diameter of >30 mm was observed in 28 subjects (incidence: 3.8%). Mean abdominal aortic diameter was 34.7 mm. A diameter >29 mm was observed in 33 subjects (incidence 4.5%). Mean abdominal aortic diameter was 30.4 mm. On the basis of epidemiological data collected, a high-risk population for AAA was identified. Arterial hypertension (p < 0.05), previous coronary artery surgery (p < 0.05), and smoking (p < 0.06) were more common in subjects with than without AAA. The overall cost of screening was $18.175. The cost per AAA diagnosed was $551.00. [less ▲]

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See detailDelineation of groundwater protection zones based on tracer tests and transport modelling in alluvial sediments
Derouane, Johan; Dassargues, Alain ULg

in Environmental Geology (1998), 36(1-2), 27-36

Regulations aiming to protect exploitable groundwater resources were edicted in Belgium a few years ago. Therefore, prevention and protection zones are defined by law and must be determined practically ... [more ▼]

Regulations aiming to protect exploitable groundwater resources were edicted in Belgium a few years ago. Therefore, prevention and protection zones are defined by law and must be determined practically around each pumping well or spring, based on local hydrogeological conditions. The determination of hydrodynamic and hydrodispersive parameters, characterizing the local flow and transport properties of the aquifer, requires pumping and tracing tests. The interpretation of these field experiments, considering the heterogeneity of the geological layers, is performed through the use of numerical FEM simulations of the groundwater flow and pollutant transport conditions in a deterministic framework. After calibration of the model on experimental measurements, multiple simulations with contaminant injections at various points of the modeled domain allow the determination of the transfer time of the pollutant in the studied aquifer whilst taking the updated heterogeneity into account. On the basis of the computed transfer times in the saturated zone, the various prevention and protection areas can be assessed based on provisions of the law. [less ▲]

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See detailPhysiopathologie et pathogenèse des douleurs zostériennes
Rentier, Bernard ULg

in Médecine et Maladies Infectieuses (1998), 28(Sp. Iss), 848-850

The origin of post-zosterian pain appears to be multiple. It implies: neuronal lesions in the central and peripheral nervous system. Young patients are less often affected than older individuals, perhaps ... [more ▼]

The origin of post-zosterian pain appears to be multiple. It implies: neuronal lesions in the central and peripheral nervous system. Young patients are less often affected than older individuals, perhaps because of damages that are caused or not to central afferences. Pain could be due to a central hyperexcitability induced and maintained by nociceptors. Antagonists of the NMDA receptor could thus prove efficient against installation of the chronic pain by interfering with neuronal discharges of the peripheral nociceptors and the induction of a hyperexcitability. [less ▲]

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See detailDetection of irregularities in the TEC using GPS measurements. Application to a mid-latitude station
Warnant, René ULg

in Acta Geodaetica et Geophysica Hungarica (1998), 33(1), 121-128

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See detailHomologous radioimmunoassay for bovine insulin-like growth factor-binding protein-2 (IGFBP-2)
Portetelle, Daniel ULg; Vleurick, Live; Massart, Serge et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 13

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See detailObesity and nutrition in children. The Belgian Luxembourg Child Study IV.
Guillaume, Michèle ULg; Lapidus, L.; Lambert, A.

in European Journal of Clinical Nutrition (1998), 52(5), 323-8

OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium ... [more ▼]

OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium. Subjects: One thousand and twenty-eight boys and girls in age strata 6-8, 8-10 and 10-12 y, comprising 70.3% of primary cohort. METHODS: Examinations included anthropometric measurements and questionnaires covering familial, socioeconomic and psychosocial factors. A three day dietary record was obtained in 955 children. This was analysed in relation to the anthropometric data. RESULTS: In comparison with similar studies from other regions and recommended allowances, the intakes of total energy, fat, particularly saturated fat and cholesterol, were high, while consumption of carbohydrate and fiber was low, as well as the polyunsaturated/saturated ratio of fat. Total energy intake showed no or weakly significant correlations with anthropometric factors. However, total fat (P=0.045) and saturated fat (P=0.0005) intake showed consistent positive correlations with body mass index (BMI, kg/m2) and skinfold thickness, with corresponding negative relationships to carbohydrate intake (P=0.034) in boys. Such relationships were also found when calculated as energy density. These associations were not statistically significant in girls. The high fat, low carbohydrate pattern of the nutritional status seemed to be more pronounced in families where the father had a low level of education (lipids, boys, P=0.0007), and where both parents were obese (saturated fat, boys, P=0.023), suggesting involvement of socioeconomic and familial factors. CONCLUSION: The lack of correlation between factors indicating obesity and total energy intake suggests that the positive energy balance causing obesity is due mainly to a low energy output. However, since energy intake measurements are imprecise, overeating can not be excluded, particularly since elevated consumption of food with high contents of fat, found in these children seems to be poorly regulated. [less ▲]

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See detailInductively coupled plasma-mass spectrometric (ICP-MS) analysis of silicate rocks and minerals
Vander Auwera, Jacqueline ULg; Bologne, Guy; Roelandts, Iwan et al

in Geologica Belgica (1998), 1

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See detailTransplantation of hepatocytes for prevention of intracranial hypertension in pigs with ischemic liver failure
Arkadopoulos, N.; Chen, S. C.; Khalili, T. M. et al

in Cell Transplantation (1998), 7

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See detailMotor and somatosensory evoked potentials in cervical spondylotic myelopathy
MAERTENS DE NOORDHOUT, Alain ULg; MYRESSIOTIS, Sophie ULg; DELVAUX, Valérie ULg et al

in Electroencephalography and Clinical Neurophysiology (1998), 108

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See detailLa paroi bactérienne et la résistance à la pénicilline: faits, questions et espoirs
Ghuysen, Jean-Marie ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1998), 153(4), 235-41

The simplest conceivable event at the level of the gene can result in the emergence of antibiotic-resistant determinants. The bacterial world behaves as an enormous organism the cells of which exchange ... [more ▼]

The simplest conceivable event at the level of the gene can result in the emergence of antibiotic-resistant determinants. The bacterial world behaves as an enormous organism the cells of which exchange their genes with great ease and, likewise, the opportunities for the exchange of genetic material in nature is, probably, limitless. This knowledge cannot be ignored. It leads to the important conclusion that the antibiotics are societal drugs. A resistance gene which has appeared somewhere in the world can travel far and fast. [less ▲]

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See detailValeurs et pratiques éthiques en entreprises
Robert, Jocelyne ULg

in Revue de l'Institut de Sociologie (1998), 3-4

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See detailStrategies for compatibilization of polymer blends
Koning, Cor; Van Duin, Martin; Pagnoulle, Christophe et al

in Progress in Polymer Science (1998), 23(4), 707-757

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See detailComparaison empirique de méthodes de prédiction en régression linéaire multiple
Fonton, N. H.; Palm, Rodolphe ULg

in Revue de Statistique Appliquée (1998), XLVI(3), 53-64

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See detailCompte-rendu de Pascal Engel, La dispute. Une introduction à la philosophie analytique
Leclercq, Bruno ULg

in Revue Philosophique de Louvain (1998), 96

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See detailPro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency
Pernasetti, Flavia; Milner, Robert DG; al Ashwal, Abdullah A Z et al

in Journal of Clinical Endocrinology and Metabolism (1998), 83(6), 2079-83

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven ... [more ▼]

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven children with GH, PRL, and TSH deficiency from three, reportedly unrelated, Middle Eastern families, harboring a newly recognized Pro- > Ser recessive mutation in codon 239 of the Pit-1 gene. The mutated residue is located at the beginning of the second alpha-helix of the POU-homeodomain and is strictly conserved among all POU proteins. The Pro239Ser mutant binds DNA normally but is unable to stimulate transcription. [less ▲]

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See detailElectronic contribution to the thermal diffusivity: DyBa2Cu3O7-y and Y0.9Ca0.1Ba2Cu3O7-z
Dorbolo, Stéphane ULg; Bougrine, Hassan ULg; Ausloos, Marcel ULg

in International Journal of Modern Physics B : Condensed Matter Physics, Statistical Physics, Applied Physics (1998), 12(29-31), 3087-3090

The electronic contribution to the specific heat and the thermal conductivity of high-T-c superconductors is calculated with a three-dimensional band structure including saddle points and a Lawrence ... [more ▼]

The electronic contribution to the specific heat and the thermal conductivity of high-T-c superconductors is calculated with a three-dimensional band structure including saddle points and a Lawrence-Doniach coupling between the CuO2 planes. The electronic thermal diffusivity is deduced for s- and d-wave symmetry of the order parameter. Data on DyBa2Cu3O7-y and Y0.9Ca0.1Ba2Cu3O7-z and theory are in good agreement on the change of the slope near T-c. [less ▲]

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See detailModelling Hydrodynamically Dominated Marine Ecosystems
Delhez, Eric ULg

in Journal of Marine Systems (1998), 1-2

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See detailEstimation de la précision de la superposition de polygones à travers la propagation des erreurs
Semlali, El Hassan; Donnay, Jean-Paul ULg

in Bulletin de la Société Française de Photogrammétrie et Télédétection (1998), 1998(2), 28-33

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See detailReaction of N-benzylideneanilines with methyl 3-aminocrotonate catalyzed by inorganic solids
Balogh, Maria; Delaude, Lionel ULg; Hermecz, Istvan

in Heterocyclic Communications (1998), 4(5), 403-410

N-benzylideneanilines 1 react with methyl 3-aminocrotonate 2 in the presence of solid acidic catalysts (K10 montmorillonite or ZF520 zeolite) to give dimethyl 4-(substituted)phenyl-2,6dimethyl-1,4 ... [more ▼]

N-benzylideneanilines 1 react with methyl 3-aminocrotonate 2 in the presence of solid acidic catalysts (K10 montmorillonite or ZF520 zeolite) to give dimethyl 4-(substituted)phenyl-2,6dimethyl-1,4-dihydropyridine-3,5-dicarboxylates 3 as major products. Methyl 2-(methoxycarbonylmethylene)-6-methyl-4-(substituted)phenyl-1,2,3,4-tetr ahydro-5-pyridinecarboxylates 4 and methyl 4-(methoxycarbonylmethyl)-2-methyl-6- (substituted)phenyl-3-pyridinecarboxylates 5 were isolated as minor products. [less ▲]

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See detailOccupation et utilisation du sol récentes en Région wallonne : analyses et synthèses
Schmitz, Serge ULg; Christians, Charles ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1998), 1

The first part is an analytical study based on an analysis of cadastral information. It presents facts and recent evolutionary processes of land use in Wallonia, especially agriculture, forest, waste land ... [more ▼]

The first part is an analytical study based on an analysis of cadastral information. It presents facts and recent evolutionary processes of land use in Wallonia, especially agriculture, forest, waste land and urbanized areas. The information is based on the municipality scale. The paper draws a compartmentalization of Wallonia: in 1992, urbanized areas represented over 20% and 40% in the urban-industrial trench and in Walloon Brabant, spilling area for Brussels population. In Ardennes, Loraine and Fagne Famenne, Forest prevailed occupying over 40% of the land. Agriculture was the main land used over 70% on low loess plateaux and with over 55% especially in Condroz and Central Ardennes. There was a slow decrease of agriculture between 1982 and 1992, usually with less than 10% for a third of the region. Forest erratically fluctuated between -5% and +5%. On the contrary urbanized areas grew everywhere with peaks around Liege, in Walloon Brabant and along motorways. It was the result of both residential urbanization and the standard increase of land use per inhabitant. The analysis shows that, during the seventies, peaks of urbanization coincide quite well with demographic evolution typology. The second part is a continuation of the preceding analytical study. It presents typology and evolution synthesis in order to divide Wallonia into districts and analyses some mechanics especially urbanization and land policy. The analytical maps lead to the building up of two types of municipalities: urban and country land use municipalities. Within the country type, five subtypes have been characterized upon the agriculture and forest combinations. Urbanization mechanics are responsible for the schematic division into two parts by a line, the south border of Condroz and Herve plateau. Urbanization concerns first the urban-industrial trench and Walloon Brabant. Hainaut is an forests also divide Wallonia between the north and the south. The agricultural areas are first victims of the urbanization progress. [less ▲]

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See detailLe Global Positioning System au service des sciences de la Terre
Warnant, René ULg

in Ciel et Terre (1998), 114(6), 166-173

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See detailEvidence For The Occurrence Of Endophytic Prokaryotic Contaminants In Micropropogated Plantlets Of Prunus Cerasus Cv. 'Montmorency'
Kamoun, R.; Lepoivre, Philippe ULg; Boxus, P.

in Plant Cell, Tissue & Organ Culture (1998), 52(1-2),

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See detailDécouverte laparoscopique d'une leiomyomatose péritonéale disséminée: une étroite ressemblance avec la carcinose péritonéale métastatique
Heidebroek, A.; Gielen, J. L.; Kolh, Philippe ULg et al

in Annales de Chirurgie (1998), 52(3), 298-300

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See detailLe Robinier faux acacia.
Jourez, Benoît ULg

in Courrier du Bois (1998), 38(120), 13-20

Le Robinier est une essence méconnue en Belgique dont l’emploi se limite bien souvent à la fixation des talus ou à l’ornementation des parcs et avenues. Cette espèce présente, cependant, de multiples ... [more ▼]

Le Robinier est une essence méconnue en Belgique dont l’emploi se limite bien souvent à la fixation des talus ou à l’ornementation des parcs et avenues. Cette espèce présente, cependant, de multiples caractéristiques susceptibles de rencontrer un grand intérêt auprès des sylviculteurs et des utilisateurs de bois. [less ▲]

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See detailQuantitative palynology of latest Famennian events in the Sauerland.
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (1998), 15

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See detailDefects segmentation on 'Golden Delicious' apples by using colour machine vision
Leemans, Vincent ULg; Magein, Hugo ULg; Destain, Marie-France ULg

in Computers & Electronics in Agriculture (1998), 20(2), 117-130

A method based on colour information is proposed to detect defects on 'Golden Delicious' apples. In a first step, a colour model based on the variability of the normal colour is described. To segment the ... [more ▼]

A method based on colour information is proposed to detect defects on 'Golden Delicious' apples. In a first step, a colour model based on the variability of the normal colour is described. To segment the defects, each pixel of ail apple image is compared with the model. If it matches the pixel, it is considered as belonging to healthy tissue, otherwise as a defect. Two other steps refine the segmentation, using either parameters computed on the whole fruit, or values computed locally. Some results are shown and discussed. The algorithm is able to segment a wide range of defects. (C) 1998 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailLe centre de santé de l’adolescent. II. Stratégies de prise en charge
Glowacz, Fabienne ULg; Bourguignon, J. P.

in Revue Médicale de Liège (1998)

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See detailL'enfant obèse: actualités.
Guillaume, Michèle ULg; Van Aelst, C.; Burniat, W.

in ONE (1998)

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See detailEpidermal Calprotectin Expression in Lymphocyte-Depleted Cutaneous Graft-versus-Host Reaction
Pierard, Gérald ULg; Nikkels, Nazli ULg; Nikkels, Arjen ULg et al

in Archivos Argentinos de Dermatologia (1998), 48

One of the most important complications associated with bone marrow transplantation (BMT) is graft-versus-host reaction (GVHR) altering different organs. The immunosuppressive regimen frequently abates ... [more ▼]

One of the most important complications associated with bone marrow transplantation (BMT) is graft-versus-host reaction (GVHR) altering different organs. The immunosuppressive regimen frequently abates the severity of cutaneous lesions to a peculiar lymphocyto-depleted GVHR (LD-GVHR) with scant recognizable inflammatory cells and almost absence of epidermal injury. The recently revisited histological criteria for cutaneous GVHR are of little help in diagnosing such LD-GVHR. As calprotectin (L1-protein) has been reported to be expressed in several types of stressed epithelia, we assessed the epidermal calprotectin expression during LD-GVHR. Calprotectin expression was studied by immuno-histochemistry using the Mac 287 moAb in 50 cases of LD-GVHR and 40 cases of toxic reactions due to the conditioning regimens or to post-transplant drugs. Calprotectin was evidenced in normal looking keratinocytes of all cutaneous LD-GVHR cases and in the vast majority of cytotoxic drug-induced dermatitis. It is concluded that calprotectin immunoreactivity appears to be a diagnostic clue in LD-GVHR. The epidermal calprotectin expression occurs early in GVHD, irrespective of the histological grading. However, it cannot be used alone to distinguish early LD-GVHR from drug-induced dermatitis. [less ▲]

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See detailExtracellular enveloped vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope
Vanderplasschen, Alain ULg; Mathew, E.; Hollinshead, M. et al

in Proceedings of the National Academy of Sciences of the United States of America (1998), 95

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See detailVirulence Plasmids of Enterotoxigenic Escherichia Coli Isolates from Piglets
Mainil, Jacques ULg; Daube, Georges ULg; Jacquemin, Etienne et al

in Veterinary Microbiology (1998), 62(4), 291-301

Virulence plasmids of 68 ETEC isolates from piglets belonging to different pathotypes and six ETEC isolates from calves with pathotypes typical of porcine ETEC were identified with seven virulence probes ... [more ▼]

Virulence plasmids of 68 ETEC isolates from piglets belonging to different pathotypes and six ETEC isolates from calves with pathotypes typical of porcine ETEC were identified with seven virulence probes for the heat-stable (STa and STb) and heat-labile (LT) enterotoxins, for the F4, F5, F6, and F41 fimbrial adhesion subunit, and also with five Rep probes for the RepFIA and RepFIB basic replicons, and the RepFIC family of basic replicons. With the exception of the F41 probe, the other virulence probes hybridized with at least one plasmid band of a size range from 65 to more than 100 Mda. Common associations of virulence factor-encoding genes on plasmid bands were: STb/LT, STa/F5, STa/F6, STa/STb. Other associations, STa/F4, STa/F4/F6, and STa/STb/LT/F6, were rarer. On the other hand the F4 adhesin-encoding genes were isolated on one plasmid band in all but three F4+ isolates. All but one of the 92 virulence plasmids which were studied have Rep probe hybridization profiles and replicon types typical of the uni- or multireplicon plasmids belonging to the various incompatibility groups of the F incompatibility complex. [less ▲]

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See detailA dustfall event in November 1996 in Genoa, Italy.
Ozer, Pierre ULg; Erpicum, Michel ULg; Cortemiglia, Gian Camillo et al

in Weather (1998), 53(5), 140-145

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See detailSynthesis of poly(norbornene-g-ε-caprolactone) copolymers by sequential controlled ring opening polymerization
Lecomte, Philippe ULg; Mecerreyes, David; Dubois, Philippe ULg et al

in Polymer Bulletin (1998), 40(6), 631-638

Poly(norbornene-g-ε-caprolactone) copolymers have been prepared by the "grafting from" technique. Well controlled polynorbornene containing 5% acetate pendant groups has been firstly synthesized by ... [more ▼]

Poly(norbornene-g-ε-caprolactone) copolymers have been prepared by the "grafting from" technique. Well controlled polynorbornene containing 5% acetate pendant groups has been firstly synthesized by ruthenium complex-mediated ring opening metathesis polymerization. The acetate groups have been derivatized into aluminum alkoxides by hydrolysis into alcohol followed by reaction of the alcohol with triethylaluminum. The two polymerization steps are under complete control, so that graft copolymers have been synthesized with a narrow molecular weight distribution and are free from any detectable traces of the parent homopolymers as stated by selective fractionation experiments. These original copolymers have been characterized by SEC, FTIR, 1H NMR, DSC, TGA. [less ▲]

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See detailThe Perturbed Generalized Proximal Point Algorithm
Alexandre, Patrick; Nguyen, Van Hien; Tossings, Patricia ULg

in RAIRO : Modélisation Mathématique et Analyse Numérique (Mathematical Modelling and Numerical Analysis) (1998), 32(2), 223-253

During the last years, different modifications were introduced in the proximal point algorithm devloped by R.T. Rockafellar for searching a zero of a maximal monotone operator on a real Hilbert space. We ... [more ▼]

During the last years, different modifications were introduced in the proximal point algorithm devloped by R.T. Rockafellar for searching a zero of a maximal monotone operator on a real Hilbert space. We combine these modifications to get a new version of this algorithm. We take simultaneously into account a variable metric, a perturbation and a kind of relaxation. Our work takes place in the context of the variational convergence theory. [less ▲]

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See detailLiver assist systems: state of the art.
Arkadopoulos, N.; Detry, Olivier ULg; Rozga, J. et al

in International Journal of Artificial Organs (1998), 21(12), 781-7

Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with ... [more ▼]

Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with liver tissue. However, no system has achieved wide clinical use and - in the absence of liver transplantation - severe hepatic failure continues to be associated with significant morbidity and mortality. In this paper, the authors review the current status of liver assist systems and summarize their clinical experience with a xenogeneic cell based-bioartificial liver. [less ▲]

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See detailLes Miracles de saint Quirin de Malmedy, un livret médiéval au coeur du XVIe siècle
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1998), CLXIV

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See detailLiver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty.
Luyckx, Françoise ULg; Desaive, Claude ULg; Thiry, Albert ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1998), 22(3), 222-6

OBJECTIVE: To examine the factors associated with liver steatosis in severely obese subjects and to test the potential reversibility of fatty liver after weight loss. DESIGN: Retrospective clinical study ... [more ▼]

OBJECTIVE: To examine the factors associated with liver steatosis in severely obese subjects and to test the potential reversibility of fatty liver after weight loss. DESIGN: Retrospective clinical study. SUBJECT: 528 obese patients before bariatric surgery and 69 obese subjects of the initial cohort evaluated before and 27+/-15 months after gastroplasty. MEASUREMENTS: Fatty deposition (scored as mild, moderate or severe) and inflammatory changes were evaluated in liver biopsies; clinical (body mass index (BMI), age, gender, duration of obesity) and biological (glucose, triglycerides, liver enzymes) parameters were related to histological findings. RESULTS: 74% of the 528 biopsies showed fatty change, estimated as mild in 41% of cases, moderate in 32% and severe in 27%. The prevalence of steatosis was significantly higher in men than in women (91% vs 70%, P = 0.001) and in patients with impaired glucose tolerance or type 2 diabetes compared with nondiabetics (89% vs 69% P = 0.001). The severity of the steatosis was associated with BMI (P = 0.002) but not with the duration of obesity or the age of the patient. When compared with patients without fatty change, those with liver steatosis had significantly higher fasting plasma glucose (5.5 mmol/l vs 5.1 mmol/l, P = 0.007) and triglycerides (1.8 mmol/l vs 1.3 mmol/l, P = 0.002). Mean serum liver enzyme activities (alkaline phosphatase, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl-transpeptidase (gammaGT) were significantly (P < 0.001) increased in patients with fatty change but remained within laboratory reference values. In the 69 patients who have been evaluated after a marked weight reduction (-32+/-19kg), 45% of the biopsies were considered as normal (vs 13% before, P < 0.001) while pure fatty change was still observed in 38% of the patients (vs 83% before, P = 0.001). However, the severity of the steatosis was significantly (P < 0.001) reduced (mild: 62% vs 21%; moderate: 23% vs 37%; severe: 15% vs 42%). In addition, a significant increase of hepatitis was observed in 26% of the biopsies (vs 14% before, P < 0.05). CONCLUSIONS: Liver steatosis in obese subjects is associated with men, diabetic status, BMI, higher fasting glucose and hypertriglyceridaemia. Postgastroplasty weight loss reduces liver steatosis, but seems to increase the incidence of inflammatory lobular hepatitis. [less ▲]

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See detailLa littérature engagée selon Camus
Badir, Sémir ULg

in Ecritures (1998), 10

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See detailPurification of myeloperoxidase from equine polymorphonuclear leucocytes.
Mathy, Marianne ULg; Bourgeois, E.; Grulke, Sigrid ULg et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1998), 62(2), 127-32

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute ... [more ▼]

Increases of plasma concentrations of neutrophil myeloperoxidase (MPO) can be used as markers of polymorphonuclear leucocytes (PMN) activation in pathological situations (sepsis, acute lung injury, acute inflammation). To develop an assay for measurement of plasma MPO in horses during the above-mentioned infectious and inflammatory conditions, MPO was purified from equine PMN isolated from blood anticoagulated with citrate. PMN were extracted in a saline milieu (0.2 M Na acetate, 1 M NaCl, pH 4.7) to eliminate most of cellular proteins. Pellets were then extracted in the same buffer containing cationic detergent (1% cetyltrimethyl ammonium bromide). The supernatant was further purified by ion exchange chromatography (Hiload S Sepharose HP column 0.5 x 26 cm, equilibrated with 25 mM Na acetate, 0.2 M NaCl, pH 4.7) with a NaCl gradient (until 1 M). Most of the peroxidase activity of MPO (spectrophotometrically measured by the oxidation of orthodianisidine by hydrogen peroxide) was eluted at 0.65 M NaCl. MPO was further purified by gel filtration chromatography (Sephacryl S 200 column 2.6 x 42 cm with 25 mM Na acetate, 0.2 M NaCl, pH 4.7). MPO (specific activity: 74.3 U/mg) was obtained with a yield of 30% from the detergent extraction supernatant. Electrophoresis (non-reducing conditions) showed 3 bands identified, by comparison with human MPO, (i) the mature tetrameric enzyme (150 kDa) with 2 light and 2 heavy subunits, (ii) the precursor form (88 kDa) and (iii) a form of the heavy subunit without the prosthetic heme group (40 kDa). The mature enzyme and its precursor were glycosylated and possessed peroxidase activity. Equine MPO showed strong similarities with human and bovine MPO, with an absorption peak at 430 nm (Soret peak) characteristic of ferrimyeloperoxidase. Enzymatic activity was pH dependent (optimal value at pH 5.5). [less ▲]

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See detailMagnetic flux penetration and creep in BSSCO-2223 composite ceramics
Vanderbemden, Philippe ULg; Destombes, Christophe; Cloots, Rudi ULg et al

in Superconductor Science and Technology (1998), 11(1), 94-100

We have experimentally investigated the magnetic flux penetration through a Bi-2223 polycrystalline superconductor synthesized by a classical solid-state reaction method. Electrical resistance, AC ... [more ▼]

We have experimentally investigated the magnetic flux penetration through a Bi-2223 polycrystalline superconductor synthesized by a classical solid-state reaction method. Electrical resistance, AC susceptibility, the Campbell method and magnetic flux waveform recordings have been analysed and compared in order to separate clearly intergrain and intragrain contributions. The AC susceptibility frequency dependence has been also examined at T = 77 K in a broad field range (0.01 G < B-AC < 100 G) The activation energy as a function of AC applied magnetic field is found to present a pronounced minimum for an induction (8 G) corresponding to full magnetic flux penetration through the intergranular matrix. [less ▲]

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See detailUtilisation des images satellitaires à très haute résolution pour la mise en œuvre de la révision des plans de secteur
Binard, Marc ULg; Nadasdi, Isvan

in Bulletin de la Société Géographique de Liège (1998), 34

Research, on the one hand, confirms the availability of land for additional housing developments, and on the other reveals the consequences of bad urbanization policies (promotion and development of ... [more ▼]

Research, on the one hand, confirms the availability of land for additional housing developments, and on the other reveals the consequences of bad urbanization policies (promotion and development of linear housing developments, insufficient control over quarrying activities, etc.). The "new code" introduces new town planning requirements (more detailed zoning analysis taking into account the environmental aspects, creation of protected areas, impact surveys, ground occupancy estimation) and strengthens the prospect of using this methodology further on. [less ▲]

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See detailInhibition of urokinase activity by the antiangiogenic factor 16K prolactin: activation of plasminogen activator inhibitor 1 expression
Lee, H.; Struman, Ingrid ULg; Clapp, C. et al

in Endocrinology (1998), 139(9), 3696-703

The N-terminal fragment of PRL (16K PRL) is an antiangiogenic factor that, in vitro, inhibits several components of angiogenesis including basic fibroblast growth factor (bFGF)-induced cell division ... [more ▼]

The N-terminal fragment of PRL (16K PRL) is an antiangiogenic factor that, in vitro, inhibits several components of angiogenesis including basic fibroblast growth factor (bFGF)-induced cell division, migration, and organization of capillary endothelial cells. An essential step in the regulation of angiogenesis is the activation of urokinase (urokinase type plasminogen activator, uPA), which in turn activates a cascade of proteases that play essential roles in endothelial cell migration and tissue remodeling. Treatment of bovine capillary endothelial cells (BBEC) with 16K PRL inhibited bFGF-stimulated urokinase activity in BBEC as detected by plasminogen substrate gel assay. 16K PRL did not appear to be acting via an effect on uPA expression because no change in messenger RNA levels were observed. However, protein levels of plasminogen activator inhibitor-1 (PAI-1), a specific inhibitor of urokinase, were increased by 16K PRL independent of the action of bFGF. The 16K PRL-induced increase in PAI-1 protein levels appear to be the result of increased expression of the PAI-1 gene. Increased production of PAI-1 induced by 16K PRL results in the formation of inactive PAI-1/uPA complexes, consistent with the observed decrease in uPA activity. [less ▲]

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See detailNorthern and southern hemisphere ground-based infrared spectroscopic measurements of tropospheric carbon monoxide and ethane
Rinsland, C. P.; Jones, N. B.; Connor, B. J. et al

in Journal Of Geophysical Research. Atmospheres (1998), 103(D21), 28197-28217

Time series of CO and C2H6 measurements have been derived from high-resolution infrared solar spectra recorded in Lauder, New Zealand (45.0 degrees S, 169.7 degrees E, altitude 0.37 km), and at the U.S ... [more ▼]

Time series of CO and C2H6 measurements have been derived from high-resolution infrared solar spectra recorded in Lauder, New Zealand (45.0 degrees S, 169.7 degrees E, altitude 0.37 km), and at the U.S. National Solar Observatory (31.9 degrees N, 111.6 degrees W, altitude 2.09 km) on Kitt Peak. Lauder observations were obtained between July 1993 and November 1997, while the Kitt Peak measurements were recorded between May 1977 and December 1997. Both databases were analyzed with spectroscopic parameters that included significant improvements for C2H6 relative to previous studies. Target CO and C2H6 lines were selected to achieve similar vertical samplings based on averaging kernels. These calculations show that partial columns from layers extending from the surface to the mean tropopause and from the mean tropopause to 100 km are nearly independent. Retrievals based on a semiempirical application of the Rodgers optimal estimation technique are reported for the lower laver, which has a broad maximum in sensitivity in the upper troposphere. The Lauder CO and C2H6 partial columns exhibit highly asymmetrical seasonal cycles with minima in austral autumn and sharp peaks in austral spring. The spring maxima are the result of tropical biomass burning emissions followed by deep convective vertical transport to the upper troposphere and long-range horizontal transport. Significant year-to-year variations are observed for both CO and C2H6, but the measured trends, (+0.37 +/- 0.57)% yr(-1) and (-0.64 +/- 0.79)% yr(-1), 1 sigma, respectively, indicate no significant long-term changes. The Kitt Peak data also exhibit CO and C2H6 seasonal variations in the lower layer with trends equal to (-0.27 +/- 0.17)% yr(-1) and (-1.20 +/- 0.35')% yr(-1), 1 sigma, respectively. Hence a decrease in the Kitt Peak tropospheric C2H6 column has been detected, though the CO trend is not significant. Both measurement sets are compared with previous observations, reported trends, and three-dimensional model calculations. [less ▲]

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See detailBiorthogonal wavelets in H-m(R)
Bastin, Françoise ULg; Boigelot, Christine

in Journal Of Fourier Analysis And Applications (1998), 4(6), 749-768

This article is concerned with constructions of biorthogonal basis of compactly supported wavelets in Sobolev spaces of integer order. Using techniques of [1] and [2], the results presented here ... [more ▼]

This article is concerned with constructions of biorthogonal basis of compactly supported wavelets in Sobolev spaces of integer order. Using techniques of [1] and [2], the results presented here generalize to Sobolev spaces some constructions of Cohen et al. [7] and Chui and Wang [5] established in L-2(R). [less ▲]

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See detailLe curateur aux meubles et les scellés
Moreau, Pierre ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederechters (1998), (8, 9, 10), 481-490

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See detailLe colza en Belgique. Production et recherche.
Cartrisse, Christine; Wathelet, Jean-Paul ULg

in Bulletin du GCIRC (1998), 15

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See detailNiertransplantatie: de ingreep zelf
Detry, Olivier ULg; Bonnet, Pierre ULg; Meurisse, Michel ULg

in Horizon (1998), 70

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See detailMammals from the Azores islands (Portugal): an updated overview
Mathias, Maria da Luz; Ramalhinho, Maria Graça; Santos-Reis, Margarida et al

in Mammalia (1998), 62(3), 397-407

Nine species of mammals are recorded for the Azores islands: one insectivore (Erinaceus europaeus), two bats (Myotis myotis, Nyctalus azoreum), one lagomorph (Oryctolagus cuniculus), three rodents (Rattus ... [more ▼]

Nine species of mammals are recorded for the Azores islands: one insectivore (Erinaceus europaeus), two bats (Myotis myotis, Nyctalus azoreum), one lagomorph (Oryctolagus cuniculus), three rodents (Rattus norvegicus, R. rattus, Mus musculus domesticus) and two carnivores (Mustela nivalis, M. furo). Here, notes on the origin and known distribution are given for each species, together with taxonomical and ecological cmments. Except for bats all the remaining species seem to have been introduced under the influence of the man's exploratory and commercial activities [less ▲]

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