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See detailPregnancies after vitrification of human day 5 embryos
Vanderzwalmen, Pierre ULg; Delval, Alain; Chatziparasidou, A. et al

in Human Reproduction (1997), 12(suppl), 98

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See detailEvolution du couvert vegetal dans la region de Kinshasa (1960-1987) selon une approche cartographique.
Tshibangu, K. W. T.; Engels, Patrick ULg; Malaisse, François ULg

in Geo-Eco-Trop (1997), 21(1-4),

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See detailEmission from cobalt in type Ia supernovae
Liu, W; Jeffery, D J; Schultz, D R et al

in Astrophysical Journal (1997), 489

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See detailManifestations indésirables des antidépresseurs
Charlier, Corinne ULg; Ansseau, Marc ULg; Pinto, Emmanuel ULg et al

in Toxicorama (1997), (Spécial LYON), 310-314

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See detailRadiation therapy duration influences overall survival in patients with cervix carcinoma.
Coucke, Philippe ULg; Delaloye, J-F; Pampallona, S et al

in International Journal of Gynecology & Obstetrics (1997), 57

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation ... [more ▼]

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to the duration of the therapies, taking 60 days (the 75th percentile) as an arbitrary cut-off. Results: The 5-year survival was 61% (SE. = 3%) for the therapy duration group of less than 60 days and 53% (SE. = 7%) for the group of more than 60 days. In terms of univariate hazard ratio (HR), the relative difference between the hvo groups corresponds to a 50% increase of deaths (HR = 1.53, 95% CI = 1.03-2.28) for the longer therapy duration group (P = 0.044). In a multivariate analysis, the magnitude of estimated relative hazards for the longer therapies are confirmed though significance was reduced (HR = 1.52, 95% CI = 0.94-2.45, P = 0.084). Conclusion: These findings suggesthat short treatment duration is a factor associated with longer survival in carcinoma of the cervix. 0 1997 International Federation of Gynecology and Obstetrics [less ▲]

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See detailHuman follicular dendritic cells in vitro and follicular dendritic-cell-like cells.
Tsunoda, R.; Bosseloir, A.; Onozaki, K. et al

in Cell & Tissue Research (1997), 288(2), 381-9

Human follicular dendritic cell (FDC)-like cells (FLC) have been utilized for the in vitro analysis of germinal center reactions. However, there is no consensus whether FLC represent FDC in vitro. The ... [more ▼]

Human follicular dendritic cell (FDC)-like cells (FLC) have been utilized for the in vitro analysis of germinal center reactions. However, there is no consensus whether FLC represent FDC in vitro. The purpose of the present study has therefore been to determine distinguishing features of FDC and FLC in vitro. The expression of CD40, CD54, CD49d, cytokine (gamma-IFN and IL-4)-dependent MHC-class II, and CD106 was observed to be specific for the determination of FDC in long-term culture. The cytokine-dependent emperipolesis of germinal center B cells was establised as another discriminating property for FDC in vitro. In 2 out of 72 long-term cultures of FDC, we encountered dividing cells among the non-dividing population of FDC. The dividing cells expressed accessory molecules similar to those of FDC but showed emperipolesis only for the initial few days of their growth. FDC did not enhance the CD40-dependent proliferation of germinal center B cells; in contrast, FLC augumented it. Both types of cells produced a significant amount of cytokine-dependent IL-6. Further studies are needed to determine whether FLC originate from FDC in vitro. [less ▲]

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See detailComparison of hindquarter metabolite uptakes in Belgian Blue double-muscled bulls at maintenance or during fattening.
Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg; Diez, Marianne ULg et al

in Journal of Animal Science (1997), 75(12), 3331-41

Metabolism of muscle growth in the hindquarter was investigated by the arterio-venous difference (AVD) technique in Belgian Blue double-muscled type bulls at maintenance or at fattening. The bulls were ... [more ▼]

Metabolism of muscle growth in the hindquarter was investigated by the arterio-venous difference (AVD) technique in Belgian Blue double-muscled type bulls at maintenance or at fattening. The bulls were fitted with an aortic ultrasonic blood flow probe and with catheters in the aorta and vena cava. They were offered a diet allowing for maintenance (MP) during a period of 15 d, at the end of which measurements were made over 3 d. Bulls were then given a fattening diet (FP) and the measurements were repeated. Arterial blood flow was approximately 1 L/min greater when the bulls were standing than when lying. Blood flow was 2 L/min higher during FP than during MP. The AVD and uptake of glucose were maximal at 1400 and 1600. Uptake of alpha-amino nitrogen decreased immediately after a meal. The increase in glucose from MP to FP fitted very well with the calculated energy needs for muscle growth. The AVD and uptake of alpha-amino nitrogen, total amino acids, and total nonessential amino acids were negative during MP and positive and significantly higher during FP. There was also a significant increase in AVD and uptake of essential and branched-chain amino acids when the bulls were changed from MP to FP. When changing from maintenance to fattening, the incremental glucose and amino acid hindquarter uptake provided energy and supply for muscle protein accretion, respectively. The level of alanine transamination was also sharply reduced. [less ▲]

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See detailFast and slow tracks in lysozyme folding: Insight into the role of domains in the folding process
Matagne, André ULg; Radford, S. E.; Dobson, C. M.

in Journal of Molecular Biology (1997), 267(5), 1068-1074

The folding of lysozyme involves parallel events in which hydrogen exchange kinetics indicate the development of persistent structure at very different rates. We have monitored directly the kinetics of ... [more ▼]

The folding of lysozyme involves parallel events in which hydrogen exchange kinetics indicate the development of persistent structure at very different rates. We have monitored directly the kinetics of formation of the native molecule by the binding of a fluorescently labelled inhibitor, MeU-diNAG (4-methylumbelliferyl-N,N'-diacetyl-beta-D-chitobioside). The data show that native character monitored in this way also develops with different timescales. Although the rate determining step on the slow pathway (similar to 75% of molecules at pH 5.5, 20 degrees C) can be attributed to the need to reorganise structure formed early in the folding process, the data indicate that the rate determining step on the fast track (involving similar to 25% of molecules) involves the docking of the two constituent domains of the protein. In the fast folding track the data are consistent with a model in which each domain forms persistent structure prier to their docking in a locally cooperative manner on a timescale comparable to the folding of small single domain proteins. (C) 1997 Academic Press Limited. [less ▲]

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See detailcDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.
Colige, Alain ULg; Li, S. W.; Sieron, A. L. et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94(6), 2374-9

Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and ... [more ▼]

Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and sheep, and they cause type VIIC Ehlers-Danlos syndrome in humans, heritable disorders characterized by accumulation of pNcollagen and severe skin fragility. Amino acid sequences for the N-proteinase were used to obtain cDNAs from bovine skin. Three overlapping cDNAs had an ORF coding for a protein of 1205 residues. Mammalian cells stably transfected with a complete cDNA secreted an active recombinant enzyme that specifically cleaved type I procollagen. The protein contained zinc-binding sequences of the clan MB of metallopeptidases that includes procollagen C-proteinase/BMP-1. The protein also contained four repeats that are homologous to domains found in thrombospondins and in properdin and that can participate in complex intermolecular interactions such as activation of latent forms of transforming growth factor beta or the binding to sulfatides. Therefore, the enzyme may play a role in development that is independent of its role in collagen biosynthesis. This hypothesis was supported by the observation that in some tissues the levels of mRNA for the enzyme are disproportionately high relative to the apparent rate of collagen biosynthesis. [less ▲]

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See detailThe Nucleotide Sequence Of Saccharomyces Cerevisiae Chromosome Xv
Dujon, B.; Albermann, K.; Aldea, M. et al

in Nature (1997), 387(6632),

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See detailThe TEL gene products: nuclear phosphoproteins with DNA binding properties.
Poirel, H.; Oury, Cécile ULg; Carron, Clémence et al

in Oncogene (1997)

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute ... [more ▼]

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events. [less ▲]

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See detailA two-dimensional Navier-Stokes inverse solver for compressor and turbine blade design
Demeulenaere, A.; Léonard, Olivier ULg; Van den Braembussche, René

in Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy (1997), 211(4), 299-307

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on ... [more ▼]

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on the blade surface. The method solves the time-dependent Navier-Stokes equations in a numerical domain of which some boundaries (the blade walls) move during the transient part of the computation. The geometry modification algorithm is based on the transpiration principle: a normal velocity distribution is computed from the difference between the actual and prescribed pressure distributions, and is used to modify the blade shape. A time iteration is then performed on this new blade shape, taking into account the grid movement during the time stepping. A two-dimensional upwind finite-volume Navier-Stokes solver has been developed. The multiblock strategy allows for a selective concentration of the discretization points in the zones of higher gradients. Applications to turbine and compressor blade design illustrate the accuracy of the flow computation, the capabilities and efficiency of the inverse method. [less ▲]

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See detailEarliest Taeniate Bisaccates from the Amazon basin are not older than Westphalian.
Loboziak, S; Melo, J.H.G.; Dino, R et al

in Geobios (1997), 30(4), 467-474

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See detailProcesses in regions of freshwater influence (ROFI)
Nihoul, Jacques ULg; Djenidi, Salim ULg; Huthnance, J. M. et al

in Journal of Marine Systems (1997), 12(1-4), 1-2

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See detailPolarization dependence of the exchange energy
Gonze, X.; Ghosez, Philippe ULg; Godby, R. W.

in Physical Review Letters (1997), 78(10), 2029-2029

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See detailFluidothérapie parentérale pratique chez les bovins
Rollin, Frédéric ULg

in Annales de Médecine Vétérinaire (1997), 141(2), 89-111

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte ... [more ▼]

After setting up the main indications for parenteral fluid therapy in calves and adult cattle, the means are studied to practically evaluate on the field the dehydration, acid-base status, electrolyte disturbances and glycemia. The various classes of fluids are then considered as a function of the indications. Use of transfusion, hypertonic solutions and parenteral nutrition is broached. Routes and techniques of fluid administration are detailed. Obstacles encountered by the bovine practitioner when using parenteral fluid therapy are emphasized just as the means to overcome them. In this regard, it is described how to correctly prepare fluids for suited parenteral use in cattle. In fact, the present laws do not given this allowance to the practitioners. However, in most cases, it constitutes the only economical option avoiding worthless sufferings and death of the animal. [less ▲]

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See detailMise au point d'une technique de culture in vitro d'embryons immatures de Phaseolus.
Mergeai, Guy ULg; Schmit, V.; Baudoin, Jean-Pierre ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(1),

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See detailKarst non carbonaté au Cameroun méridional. L'exemple des grottes de Mfoula
Willems, Luc ULg; Pouclet, André; Vicat, Jean-Paul

in Würzburger Geographische Arbeiten (1997), 89

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See detailFibres alimentaires chez le chien II. Effets sur la vidange gastrique et le transit gastro-intestinal
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is ... [more ▼]

The aim of this second review is to summarize data on the duration of gastric emptying and on the transit time in the gastrointestinal tract of healthy dogs. An overview of the investigation techniques is also given. The incorporation of fibres in the diet is one of many other factors which influence the mechanisms of emptying in the gastrointestinal tract. The effect of dietary fibres is also discussed in other monogastric species [less ▲]

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See detailPEGASE, une méthodologie et un outil de simulation prévisionnelle pour la gestion de la qualité des eaux de surface
Smitz, Joseph ULg; Everbecq, Etienne ULg; Deliège, Jean-François ULg et al

in Tribune de l'Eau (La) (1997), 50/4(588), 73-82

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle ... [more ▼]

PEGASE (Planification Et Gestion de l’ASsainissement des Eaux) est un modèle intégré bassins hydrographiques/rivières développé à l’Aquapôle qui permet de calculer de façon déterministe et prévisionnelle la qualité des eaux des rivières en fonction des rejets et apports de pollution. PEGASE est un outil opérationnel permettant d’orienter les choix des opérateurs publics et privés en matière de gestion des eaux de surface à l’échelle des bassins versants [less ▲]

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See detailUse of recombinant human erythropoietin after allogeneic bone marrow transplantation
Hermanne, J.-P.; Beguin, Yves ULg

in Erythropoiesis (1997), 8

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See detailAbdominal sequelae after pedicled TRAM flap breast reconstruction
PETIT, JY; RIETJENS, M; FERREIRA, M et al

in Plastic and Reconstructive Surgery (1997), 99

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants ... [more ▼]

A considerable interest in autologous tissue breast reconstructions has developed recently, especially since Food and Drug Administration (FDA) experts have raised the polemic on silicone implants. Although such enthusiasm for the transverse rectus abdominis musculocutaneous (TRAM) flap is justified in what concerns the final cosmetic result of the reconstructed breast, the risk of abdominal sequelae should be explained to the patient. Abdominal scarring, parietal weakness, strength loss, and back pain have been recorded in a series of pedicled TRAM flap reconstructions performed at the Institut Gustave-Roussy before 1991. Cosmetic results of the abdomen were tested by three independent judges on the photographs taken of 132 patients. The global appearance of the abdomen was rated as "natural" in 70 percent of the patients. The umbilical scar was unacceptable in 25 percent and very good or not visible in 21 percent. The lower abdominal scar was rated as "not acceptable" in 35 percent. Abdominal strength was tested among the 38 patients who underwent both preoperative and postoperative muscular testing, of whom 18 had single-pedicled and 20 had bipedicled TRAM flap reconstructions. In the first group, the physiotherapist observed an impairment of function of the upper portion of the rectus abdominis and of the oblique muscle in almost 50 percent. In the second group, the same muscles were more severely impaired (in 60 percent), as well as the function of the lower portion of the rectus (in 15 percent). The percentage of patients complaining of "light back pain" in the 6-month postoperative period was 55 percent in the single-pedicle group and 30 percent in the double-pedicle group. However, 20 percent of the bipedicled patients complained of "severe" back pain, while there was none in the single-pedicled group. In conclusion, abdominal sequelae after TRAM flap breast reconstruction should not be underestimated and constitute one of the drawbacks of the technique when it is compared with reconstruction with a prosthesis. [less ▲]

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See detailFibres alimentaires chez le chien : VII. Intérêt dans le traitement diététique de l'animal obèse
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

The present review deals with obesity in the dog, Definition, incidence, assessment, etiology and detrimental effects of obesity are firstly presented. In a second part, the treatment is discussed, with ... [more ▼]

The present review deals with obesity in the dog, Definition, incidence, assessment, etiology and detrimental effects of obesity are firstly presented. In a second part, the treatment is discussed, with particular emphasis on the incorporation of large quantities of dietary fibres in low-energy specific purpose food. At present time, no conclusions can be drawn from published studies [less ▲]

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See detailQuantitative ultrasound techniques for the assessment of osteoporosis : Expert agreement on current status
Glüer, CC; Reginster, Jean-Yves ULg

in Journal of Bone and Mineral Research (1997), 12(8), 1280-1288

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See detailEpilepsies rebelles de l'enfant: définition et modalités de prise en charge hospitalière
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Neurone (1997), 2(8), 285-288

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See detailCompte rendu de VAUCHEZ (A.), La spiritualité du Moyen Age occidental VIIIe-XIIIe siècle, Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailFibres alimentaires chez le chien III. Effets sur les structures intestinales et les fermentations. Applications dans le traitement de certains dysfonctionnements intestinaux
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1997), 141

Dietary fibres can modify the intestinal structure in dogs and other animal species. The main changes concern not only the morphology of the gastrointestinal tract but also the ultrastructures ... [more ▼]

Dietary fibres can modify the intestinal structure in dogs and other animal species. The main changes concern not only the morphology of the gastrointestinal tract but also the ultrastructures. Furthermore, soluble and partly-soluble fibres are fermented in the large bowel; the fermentation products have different metabolic effects. The physical and chemical properties of fibres can be used for the dietary therapy of some intestinal pathologies [less ▲]

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See detailModulation of lung inflammation in the control of bovine respiratory disease
Van de Weerdt, ML; Lekeux, Pierre ULg

in Bovine Practitioner (1997), 31.1

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible ... [more ▼]

The purpose of this paper is to review the potential strategies which could improve the treatment of respiratory disorders in general and the modulation of lung inflammation in particular. Possible preventive treatments will not be discussed in this review. [less ▲]

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See detailImpaired LTP induction in dentate gyrus of calretinin-deficient mice
Schurmans, Stéphane ULg; Schiffmann, S. N.; Gurden, H. et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94

Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting ... [more ▼]

Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting and have investigated the associated phenotype. Cr2/2 mice were viable, and a large number of morphological, biochemical, and behavioral parameters were found unaffected. In the normal mouse hippocampus, Cr is expressed in a widely distributed subset of GABAergic interneurons and in hilar mossy cells of the dentate gyrus. Because both types of cells are part of local pathways innervating dentate granule cells andyor pyramidal neurons, we have explored in Cr2/2 mice the synaptic transmission between the perforant pathway and granule cells and at the Schaffer commissural input to CA1 pyramidal neurons. Cr2/2 mice showed no alteration in basal synaptic transmission, but long-term potentiation (LTP) was impaired in the dentate gyrus. Normal LTP could be restored in the presence of the GABAA receptor antagonist bicuculline, suggesting that in Cr2/2 dentate gyrus an excess of g-minobutyric acid (GABA) release interferes with LTP induction. Synaptic transmission and LTP were normal in CA1 area, which contains only few Cr-positive GABAergic interneurons. Cr2/2 mice performed normally in spatial memory task. These results suggest that expression of Cr contributes to the control of synaptic plasticity in mouse dentate gyrus by indirectly regulating the activity of GABAergic interneurons, and that Cr2/2 mice represent a useful tool to understand the role of dentate LTP in learning and memory [less ▲]

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See detailCompte rendu de Moines et religieux au Moyen Age, éd. BERLIOZ (J.), Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailAssessment of pain in herpes zoster: lessons learned from antiviral trials
Dworkin, R. H.; Carrington, D.; Cunningham, A. et al

in Antiviral Research (1997), 33(2), 73-85

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but ... [more ▼]

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review, recommendations for the design and analysis of future trials of antiviral agents in herpes zoster are proposed. The principal recommendation is that antiviral efficacy should be evaluated both by distinguishing post-herpetic neuralgia from acute pain and by considering pain as a continuum. The primary endpoint should address both the prevalence and duration of post-herpetic neuralgia and should be examined in those patients who have post-herpetic neuralgia. Adopting the proposed recommendations in design and analysis of future trials should facilitate comparison across trials of the efficacy of antiviral agents in the treatment of herpes zoster. [less ▲]

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See detailPsychiatrie de liaison:regards sur une pratique de la psychologie médicale en hôpital général
Triffaux, Jean-Marc ULg

in Revue francaise de psychiatrie et de psychologie médicale (1997)

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See detailRégime et tactique alimentaires de la loutre (Lutra lutra) dans le Massif Central
Libois, Roland ULg

in Vie et milieu (1997), 47(1), 33-45

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback ... [more ▼]

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback, gudgeon and minnow) are the most numerous items in the diet: they account for more than 50% of the 3,148 identified preys. However, when expressed in relative biomass, their importance falls down (8 %). In fact, the brown trout, large cyprinid fish, birds and mammals make up the bulk of the diet. We found strong differences linked to the general habitat types and also seasonal ones. Frogs are mainly preyed upon during the spring whereas the snakes are exclusively taken in the summer and autumn months. Gudgeon and insects are also mainly summer and autumn preys. Perch and large cyprinid fish remais are more frequent during winter and even spring. The present results confirm the opportunistic way of predation of the otter and the fact that its hunting takes place more on the bottom and along the river banks than in the open water. [less ▲]

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See detailmorbidity in neonates afetr labour induction or cesarean section
Battisti, Oreste ULg; Bertrand, J. M.; Adant-François, A. et al

in vlaamse verenigong voor obstetrie en gynaecologie jaarboek (1997), 1

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See detailBankfull discharge recurrence interval in gravel bed rivers
Petit, François ULg; Pauquet, A.

in Earth Surface Processes & Landforms (1997)

Bankfull discharge was identified in some 30 gravel-bed rivers representing in total c. 40 gauging stations. The catchment sizes vary from 4km2 to nearly 2700km2. Bankfull discharge values increases with ... [more ▼]

Bankfull discharge was identified in some 30 gravel-bed rivers representing in total c. 40 gauging stations. The catchment sizes vary from 4km2 to nearly 2700km2. Bankfull discharge values increases with basin size. In the case of gravel-bed rivers developed on an impermeable substratum, the following equation emerges: Qb=0·087 A1·044. Bankfull discharge recurrence interval was determined by fitting maximum annual floods (Ta) into Gumbel’s distribution and then using the partial duration series (Tp) in this same distribution. Recurrence interval is below 0·7 years (Tp) for small pebble-bed rivers developed on an impermeable substratum; it reaches 1·1 to 1·5 years when the catchment size of these rivers exceeds 250km2. Rivers incised in the soft schists of the Famenne show larger channel capacity at bankfull stage, a small width/depth ratio and thus higher recurrence intervals (1·4–5·3 years with Ta and 1–4·4 years with Tp). Baseflow-dominated gravel-bed streams and sandy or silty rivers experience less frequent bankfull discharges, with a recurrence interval higher than 2 or even 3 years (Tp). [less ▲]

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See detailA gas chromatographic separation for the H and C stable isotope ratio determination of coal compounds
Antenucci, Diano; Bouquegneau, Jean-Marie ULg; Brasseur, Alain et al

in Analytical Chemistry (1997), 69(11), 2030-2034

A new, completely automated gas chromatography technique has been developed to separate the different gaseous compounds produced during underground coal gasification for their C-13/C-12 and D/H isotope ... [more ▼]

A new, completely automated gas chromatography technique has been developed to separate the different gaseous compounds produced during underground coal gasification for their C-13/C-12 and D/H isotope ratio measurements, ?he technique was designed for separation and collection of Hz, CO, CO2, H2O, H2S, CH4, and heavier hydrocarbons. These gaseous compounds are perfectly separated by the gas-phase chromatograph and quantitatively sent to seven combustion and collection lines. H-2, CO, CH4, and heavier hydrocarbons are quantitatively oxidized to CO2 and/or H2O. The isotopic analyses are performed by the sealed-tube method, The zinc method is used for reduction of both water and H2S to hydrogen for D/H analysis, Including all preparation steps, the reproducibility of isotope abundance values, for a quantity higher than or equal to 0.1 mt of individual components in a mixture (5 mt of gases being initially injected in the gas chromatograph), is +/-0.1 parts per thousand for delta(13)C(PDB) and +/-6 parts per thousand for delta(13)C(PDB) and +/-6 parts per thousand for delta(SMOW). [less ▲]

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See detailAnomalously large Born effective charges in cubic WO3
Detraux, F.; Ghosez, Philippe ULg; Gonze, X.

in Physical Review. B : Condensed Matter (1997), 56(3), 983-985

Within density-functional theory, we compute the Born effective charges of tungsten trioxyde in its reference cubic phase (defect-perovskite structure). For the tungsten atom, the effective charge tensor ... [more ▼]

Within density-functional theory, we compute the Born effective charges of tungsten trioxyde in its reference cubic phase (defect-perovskite structure). For the tungsten atom, the effective charge tensor is isotropic, with Z(W)*=+12.51. For the oxygen atoms, the two independent components of the tensor, corresponding, respectively, to a displacement of the atom parallel or perpendicular to the W-O bond, have the values Z(O parallel to)* = -9.13 and Z(O perpendicular to)* = -1.68. Z(W)* and Z(O parallel to)* are anomalously large with respect to the nominal ionic charges (+6 on W and -2 on O), but compatible with the Born effective charges found in related ABO(3)-perovskite compounds. [less ▲]

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See detailEnantioseparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using mixtures of anionic and uncharged beta-cyclodextrins as chiral additives.
Fillet, Marianne ULg; Hubert, Philippe ULg; Crommen, Jacques ULg

in Electrophoresis (1997), 18(6), 1013-8

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta ... [more ▼]

Nine nonsteroidal anti-inflammatory drugs (NSAIDs) were enantioseparated by capillary electrophoresis using an anionic cyclodextrin derivative (sulfobutyl ether beta-cyclodextrin or carboxymethyl-beta-cyclodextrin) in combination with a neutral cyclodextrin as chiral additives to a pH 3 phosphoric acid-triethanolamine buffer. In the presence of a negatively charged cyclodextrin, the analytes were given an appropriate mobility but relatively low enantioselectivities were generally obtained when such a cyclodextrin was the only selector added to the buffer. The addition of an uncharged cyclodextrin, such as the native beta-cyclodextrin or one of its derivatives (dimethyl-, trimethyl- and hydroxypropyl-beta-cyclodextrin), to this kind of buffer containing an anionic cyclodextrin, was found to give rise to considerable improvement in chiral resolution for all compounds studied. Resolution and analysis time were optimized by varying the nature and concentration of the two cyclodextrins. The best compromise was usually achieved by the simultaneous addition of sulfobutyl ether beta-cyclodextrin and trimethyl-beta-cyclodextrin. Under optimum conditions, the enantiomers of all NSAIDs examined could be completely separated (most often with resolution values higher than 5) in short analysis times (generally lower than 15 min). [less ▲]

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See detailOrderly process of sequential cytokine stimulation is required for activation and maximal proliferation of primitive human bone marrow CD34+ hematopoietic progenitor cells residing in G0.
Ladd, A. C.; Pyatt, R.; GOTHOT, André ULg et al

in Blood (1997), 90(2), 658-68

Bone marrow (BM) CD34+ cells residing in the G0 phase of cell cycle may be the most suited candidates for the examination of cell cycle activation and proliferation of primitive hematopoietic progenitor ... [more ▼]

Bone marrow (BM) CD34+ cells residing in the G0 phase of cell cycle may be the most suited candidates for the examination of cell cycle activation and proliferation of primitive hematopoietic progenitor cells (HPCs). We designed a double simultaneous labeling technique using both DNA and RNA staining with Hoechst 33342 and Pyronin Y, respectively, to isolate CD34+ cells residing in G0(G0CD34+). Using long-term BM cultures and limiting dilution analysis, G0CD34+ cells were found to be enriched for primitive HPCs. In vitro proliferation of G0CD34+ cells in response to sequential cytokine stimulation was examined in a two-step assay. In the first step, cells received a primary stimulation consisting of either stem cell factor (SCF), Flt3-ligand (FL), interleukin-3 (IL-3), or IL-6 for 7 days. In the second step, cells from each group were washed and split into four or more groups, each of which was cultured again for another week with one of the four primary cytokines individually, or in combination. Tracking of progeny cells was accomplished by staining cells with PKH2 on day 0 and with PKH26 on day 7. Overall examination of proliferation patterns over 2 weeks showed that cells could progress into four phases of proliferation. Phase I contained cytokine nonresponsive cells that failed to proliferate. Phase II contained cells dividing up to three times within the first 7 days. Phases III and IV consisted of cells dividing up to five divisions and greater than six divisions, respectively, by the end of the 14-day period. Regardless of the cytokine used for primary stimulation, G0CD34+ cells moved only to phase II by day 7, whereas a substantial percentage of cells incubated with SCF or FL remained in phase I. Cells cultured in SCF or FL for the entire 14-day period did not progress beyond phase III but proliferated into phase IV (with <20% of cells remaining in phases I and II) if IL-3, but not IL-6, was substituted for either cytokine on day 7. G0CD34+ cells incubated with IL-3 for 14 days proliferated the most and progressed into phase IV; however, when SCF was substituted on day 7, cells failed to proliferate into phase IV. Most intriguing was a group of cells, many of which were CD34+, detected in cultures initially stimulated with IL-3, which remained as a distinct population, mostly in G0/G1, unable to progress out of phase II regardless of the nature of the second stimulus received on day 7. A small percentage of these cells expressed cyclin E, suggesting that their proliferation arrest may have been mediated by a cyclin-related disruption in cell cycle. These results suggest that a programmed response to sequential cytokine stimulation may be part of a control mechanism required for maintenance of proliferation of primitive HPCs and that unscheduled stimulation of CD34+ cells residing in G0 may result in disruption of cell-cycle regulation. [less ▲]

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See detailCharacterization of non pigmented B16 melanoma cell-derived cytotoxic factors.
Siwek, B.; De Pauw, Marie-Claire ULg; Quetin-Leclercq, J. et al

in Chemico-Biological Interactions (1997), 103(1), 59-73

We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests ... [more ▼]

We analyzed and tried to characterize substance(s) responsible for cytotoxic activities detected in culture media conditioned by non pigmented B16 melanoma cells (NPB16). The different cytological tests used showed that ultrafiltrated conditioned media (CM U1 fraction) contained several cytotoxic factors with a Mw lower than 1000 Da. These factors seemed to act either directly or indirectly on cell membranes, mitochondria, on the cell cycle and on protein and DNA synthesis. A cytotoxic activity could be found even after high dilution of CM U1. These cytotoxic factors were rapidly released by B16 cells in culture, independently of cell confluence. Their activities in the treated cells were also very fast and the cytotoxic effects were irreversible after only a few hours of treatment. These factors were not intermediate products during melanogenesis, neither polyamines, nor proteases. At least one of them seemed to be a small acidic and basic stable peptide without disulfide bounds but not heat stable. The synthesis of at least one of these cytotoxic factors was inhibited by cycloheximide and the cytotoxic activity was partially destroyed by pronase and trypsin, but not by pepsin. The cytotoxicity was not modified by copper complexants or free radical inhibitors (bovine serum albumin (BSA), tyrosine, superoxyde dismutase (SOD), catalase, vitamin E). Furthermore the levels of glutathione peroxydase activity and reduced glutathione did not change after treatment by CM U1 as compared to controls. [less ▲]

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See detailActivation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells
Legrand-Poels, Sylvie ULg; Maniglia, Salvator; Boelaert, J. R. et al

in Biochemical Pharmacology (1997)

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See detailNeurophysines et cancer pulmonaire a petites cellules
Pirard, Françoise; Pequeux, Christel ULg; Hendrick, J. C. et al

in Revue Médicale de Liège (1997), 52(1), 22-6

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See detailMolecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Biochemical and Biophysical Research Communications (1997), 237

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding ... [more ▼]

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding proteins are displayed on mature sperm cells. In each mammalian species, a restricted subset of olfactory receptors is expressed in male germ cells and displays a pattern of expression suggestive of their potential implication in the control of sperm physiology. In addition to the cDNA fragments available previously, we now report the molecular cloning of two olfactory receptor cDNAs from a human testis library. Five olfactory receptor genes expressed in germ cells were localized in the human genome by radiation hybrid mapping. Three of the genes map to the short arm of chromosome 19 (19p13.1-19p31.3), one to chromosome 11 (11q22.1-22.3), and one to chromosome 17 (17q21-22). The former two localizations fall within clusters previously identified for members of the putative olfactory receptor gene family expressed in olfactory mucosa. Similarly, sequence analysis has revealed that these testicular genes share no distinctive structural features from the other, non-testicular, members of the family. The expression of a subset of olfactory receptor genes in the male germ line is therefore not correlated to their belonging to a specific structural subgroup, or to a specific gene cluster or chromosomal segment [less ▲]

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See detailRelative and absolute in Leibniz' physics and metaphysics
Bouquiaux, Laurence ULg

in Epistemologia (1997)

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See detailIntroduction à l'analyse des données par le logiciel Minitab sous Windows
Claustriaux, Jean-Jacques ULg

in Notes de Statistique et d'Informatique (1997), (2), 1-22

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See detailThe lowest 5g-6h supermultiplet of Fe II
Biémont, Emile ULg; Johansson, S.; Palmeri, P.

in Physica Scripta (1997), 55

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See detailHiggs boson search at photon collider for M(h) = 140-GeV - 190-GeV
Ginzburg, I. F.; Ivanov, Igor ULg

in Physics Letters B (1997), 408

A Higgs boson within the mass range $M_H=140-190$ GeV can be discovered at a photon collider in the reaction $\gamma\gamma\to WW$ (with real or virtual W) with the luminosity integral about 1 fb$^{-1 ... [more ▼]

A Higgs boson within the mass range $M_H=140-190$ GeV can be discovered at a photon collider in the reaction $\gamma\gamma\to WW$ (with real or virtual W) with the luminosity integral about 1 fb$^{-1}$. The reasonable resolution in the effective mass of the WW system is required. [less ▲]

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See detailFatty acid hydroperoxides pathway in plants. A review
Fauconnier, Marie-Laure ULg; Marlier, M.

in Grasas y Aceites (1997), 48(1), 30-37

The present paper focusses on the fatty acid hydroperoxides pathways, mainly hydroperoxide lyase and hydroperoxide dehydrase. For each enzyme, the definition, occurrence and subcellular localization is ... [more ▼]

The present paper focusses on the fatty acid hydroperoxides pathways, mainly hydroperoxide lyase and hydroperoxide dehydrase. For each enzyme, the definition, occurrence and subcellular localization is presented. Particular attention is given to reaction mecanisms and to substrate specificity. Physiological roles of reaction products are also discussed. [less ▲]

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See detailTransplantation combinée du foie et du coeur chez un patient souffrant de thalassémie majeure
Detry, Olivier ULg; Defechereux, Thierry ULg; Honore, Pierre ULg et al

in Revue Médicale de Liège (1997), 52(8), 532-4

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See detailSarcoidosis: recognition and treatment guidelines
Kaye, O.; Ribbens, Clio ULg; Kahn, M. F. et al

in BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals & Gene Therapy (1997), 7(6), 441-447

Sarcoidosis is a systemic disorder of unknown aetiology characterised by noncaseating granulomas leading principally to bilateral hilar lymphadenopathies, pulmonary infiltration and skin and eye lesions ... [more ▼]

Sarcoidosis is a systemic disorder of unknown aetiology characterised by noncaseating granulomas leading principally to bilateral hilar lymphadenopathies, pulmonary infiltration and skin and eye lesions. Sarcoidosis may involve other organs, including peripheral lymph nodes, liver, spleen, nervous and musculoskeletal systems, heart, ear, nose and kidney. Although the clinical involvement of liver and heart is relatively uncommon, hepatic and cardiac granulomas are present at autopsy in about 70 to 80% and 25 to 50%, respectively, of patients with this disease. The diagnosis of sarcoidosis includes compatible clinical and/or radiological presentations and histological evidence of noninfectious and noncaseating epitheloid cell granulomas in the absence of other identifiable agents responsible for such histological lesions. Disease course is variable and usually characterised by frequent remissions, but it may become progressive and chronic in a small percentage of patients. The optimal treatment of sarcoidosis remains poorly defined. In patients with progressive pulmonary dysfunction as well as in those with severe extrapulmonary localisations, systemic corticosteroids usually represent the first approach, limited by long term toxicity and frequent relapses after treatment interruption. In the presence of refractory or corticosteroid-dependent forms of the disease, antimalarial drugs or low dosage methotrexate may be used with prolonged benefit. The indications for immunosuppressive agents such as azathioprine, chlorambucil, cyclophosphamide and cyclosporin are uncommon and limited because of potentially serious adverse effects and lack of information on their long term efficacy. In the case of ocular and limited cutaneous manifestations, local corticosteroid therapy may be useful. [less ▲]

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See detailTotal cholesterol levels during adolescence: results of a Belgian MONICA population
Paulus, D.; Saint-Remy, Annie ULg; Rorive, Georges ULg et al

in Acta Cardiologica (1997), 52(2), 182-183

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See detailProduction and activation of matrix metalloprotease-9 (MMP-9) by HL-60 promyelocytic leukemia cells
Devy, L.; Noël, Agnès ULg; Baramova, E. et al

in Biochemical and Biophysical Research Communications (1997), 238

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of ... [more ▼]

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of extracellular matrix components. As shown by gelatin zymography, HL-60 cells constitutively released significant amounts of proMMP-9 (92 kDa) and moderate amounts of proMMP-2 (72 kDa). Furthermore, casein zymography confirmed the presence of serine proteases in the form of pro-urokinase. Activation of proMMP-9 was dependent on the plasminogen activator/plasmin (PA/plasmin) system and was inhibited by aprotinin. MMP-9 was only detected in cellular extracts or conditioned media incubated with HL-60 cells, indicating that cells are essential to the activation process. Addition of plasminogen increased by 3-fold the basal invasive rate of these cells across a matrigel layer (2.1%versus0.7% in control cells after 4 h of incubation). Taken together, these results indicate that HL-60 cells exhibit an autocrine activation mechanism of proMMP-9 via the PA/plasmin system and that activation of proMMP-9 increases their invasive potential [less ▲]

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See detailLe bois de tension. 1 Définition et distribution dans l'arbre.
Jourez, Benoît ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(2), 100-112

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See detailRoles of circadian rhythmicity and sleep in human glucose regulation.
Van Cauter, E.; Polonsky, K. S.; Scheen, André ULg

in Endocrine Reviews (1997), 18(5), 716-38

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See detailPalynological evaluation of the Famennian Protosalvinia (Foerstia) Zone in the Amazon basin, Northern Brazil : a preliminary study.
Loboziak; Melo, J.H.G.; Quadros, L.P. et al

in Review of Palaeobotany and Palynology (1997), 96

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See detailEmerging Roles for Proteinases in Cancer
Noël, Agnès ULg; Gilles, Christine ULg; Bajou, Khalid ULg et al

in Invasion & Metastasis (1997), 17(5), 221-39

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these ... [more ▼]

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these processes was initially thought to be the destruction of extracellular matrices. However, recent evidence suggests that they mainly affect tumor growth rather than invasion. Proteinases can indeed generate active matrix protein fragments, influence the release, the activation and the bioavailability of growth factors, and consequently modulate tumor cell growth, apoptosis and angiogenesis. Additionally, proteinases, their receptors and/or inhibitors can be directly involved in cell migration and in the processing or shedding of cell surface proteins. Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies. [less ▲]

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See detailQuelques arthropodes de nos maisons
Loneux, Michèle ULg

in Cahiers d'Ethologie (1997), 17(1), 75-124

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See detailDrug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments.
Scheen, André ULg

in Drugs (1997), 54(3), 355-68

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various ... [more ▼]

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various pharmacological approaches to improving glucose homeostasis, but those currently used in clinical practice either do not succeed in restoring normoglycaemia in most patients or fail after a variable period of time. For glycaemic regulation, 4 classes of drugs are currently available: sulphonylureas, biguanides (metformin), alpha-glucosidase inhibitors (acarbose) and insulin, each of which has a different mode and site of action. These standard pharmacological treatments may be used individually for certain types of patients, or may be combined in a stepwise fashion to provide more ideal glycaemic control for most patients. Adjunct treatments comprise a few pharmacological approaches which may help to improve glycaemic control by correcting some abnormalities frequently associated with NIDDM, such as obesity (serotoninergic anorectic agents) and hyperlipidaemia (benfluorex). There is intensive pharmaceutical research to find new drugs able to stimulate insulin secretion (new sulphonylurea or nonsulphonylurea derivatives, glucagon-like peptide-1), improve insulin action (thiazolidinediones, lipid interfering agents, glucagon antagonists, vanadium compounds) or reduce carbohydrate absorption (miglitol, amylin analogues, glucagon-like peptide-1). Further studies should demonstrate the superiority of these new compounds over the standard antidiabetic agents as well as their optimal mode of administration, alone or in combination with currently available drugs. [less ▲]

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See detailUne chambre noire pour l’analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1997), 33

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See detailImprovement of inland navigation in developping countries: the training center of Palembang (Sumatra, Indonesia), an example of transfer of technology through education
Marchal, Jean ULg

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (1997), Nouvelle Série 42(4)(1er trimestre), 10

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See detailReactivite bronchique chez les patients diabetiques.
Piéron, Maurice ULg; Scheen, André ULg; Corhay, Jean-Louis ULg et al

in Revue des Maladies Respiratoires (1997), 14(5), 379-85

The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on ... [more ▼]

The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on the ventilatory parameters measured during a methacholine-induced bronchoconstriction test. Ten insulin-dependent diabetic patients without CAN, ten insulin-dependent diabetic patients with CAN and ten healthy volunteers, all non-smokers and free of respiratory symptoms, have undergone a functional respiratory check-up before the methacholine test. The presence of CAN was classically studied by the decrease in heart rate changes during three standardized tests (deep breathing at 6 cycles/min, Valsalva manoeuver, orthostatism) which all mainly explore the parasympathetic function. The bronchial response to methacholine was similar in the healthy subjects and in the diabetic patients without CAN. However, the fall in forced expiratory volume in 1 second induced by the highest dose of methacholine was significantly less marked in the diabetic subjects with CAN than in the two other groups. These results suggest that the diabetic autonomic neuropathy also involves the vagal innervation of the respiratory tract. [less ▲]

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See detailGezonheidszorg : actuele standpunten. Diagnostiek van osteoporose
Devogelaer, JP; Reginster, Jean-Yves ULg; Raeman, F et al

in Tijdschrift voor Geneeskunde (1997), 53(10), 639-645

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See detailFibres alimentaires chez le chien : influence de l'incorporation de pulpes de betterave ou de chicorée sur la digestibilité des nutriments et les concentrations plasmatiques de plusieurs métabolites
Diez, Marianne ULg; Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg et al

in Revue de Médecine Vétérinaire (1997), 148

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres ... [more ▼]

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres fécaux, la digestibilité des principaux nutriments et plusieurs paramètres biochimiques (glucose, insuline, azote alpha-aminé, urée, cholestérol et triglycérides) mesurés à jeun ou pendant six heures après le repas chez huit chiens adultes en bonne santé. Les régimes enrichis en pulpes ont entraîné une augmentation significative de l'excrétion fécale totale, de l'excrétion de MS dans les matières fécales, une diminution de la teneur en MS des fèces ainsi qu'une diminution des coefficients de digestibilité des principaux nutriments. Le régime contenant la pulpe de betterave a entraîné une diminution de la glycémie à jeun, de l'insulinémie et des concentrations en triglycérides postprandiales, des concentrations en urée et en cholestérol mesurées avant et après le repas. Le régime contenant la pulpe de chicorée a provoqué une diminution de l'insulinémie postprandiale, des concentrations en urée et en cholestérol à jeun et après le repas. Ces deux types de pulpes, semblables par leur composition, induisent les mêmes types d'effets sur les paramètres fécaux et la digestibilité des nutriments, mais les effets systémiques sont plus importants lors de la distribution de pulpes de betterave. [less ▲]

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See detailBiomechanical assessment of the transversalis fascia and rectus abdominis aponeurosis in inguinal herniation - Preliminary results
PANS, Alain ULg; Pierard, Gérald ULg; Albert, Adelin ULg et al

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (1997), 1

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See detailEstimation d'un indice de la valeur récréative des forêts
Lejeune, Philippe ULg; Rondeux, Jacques ULg; Verstraete, Philippe

in Mitteilungen der Abteilung für Forstliche Biometrie (1997), 97(2), 20-30

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See detailMorphological alterations of blood platelets induced by Platelet Activating Factor (PAF) and partial inhibition by Ketoprofen in calves
Bastos da Silva, Miriam; Doizé, Cécile ULg; David, Jean-Louis ULg et al

in Veterinary Research (1997), 28(5 Sep-Oct), 489-502

The influence of platelet activating factor (PAF) was investigated in vivo on the ultrastructure of bovine platelets, and on the platelet count. The effect of an intravenous administration of ketoprofen ... [more ▼]

The influence of platelet activating factor (PAF) was investigated in vivo on the ultrastructure of bovine platelets, and on the platelet count. The effect of an intravenous administration of ketoprofen (a non-steroidal anti-inflammatory drug) pretreatment followed by PAF infusion was also observed in a group of six healthy male Friesian calves. PAF infusion alone caused a moderate thrombocytopenia, which peaked one minute post challenge and returned to levels not significantly different from control after 30 min. Electron microscopy revealed that after PAF infusion, platelets lost their lentiform shape and became irregular, with many pseudopods. Their microtubules became impossible to distinguish. The numbers of alpha granules and dense bodies were significantly decreased. Glycogen particles became rare or even disappeared. Giant platelets occasionally appeared. The Golgi apparatus was more often visible and the number of mitochondria was significantly increased. Ketoprofen pretreatment lowered PAF-induced thrombocytopenia and decrease in the number of dense bodies. Under these conditions, the Golgi apparatus was rarely visible and giant platelets were not observed. These results showed that the morphological ultrastructure of blood platelets in bovines were modified following PAF infusion and that ketoprofen pretreatment before PAF infusion provided partial protection, limiting the extent of the morphological alterations and maintaining a normal platelet count [less ▲]

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See detailInformation transfer between angiographic films and CT images: a tool to delineate the target volume
Tercier, P-A; COUCKE, Philippe ULg; Fankhauser, H et al

in Radiotherapy & Oncology (1997), 45

Abstract Background and purpose: This work was undertaken to improve the definition of target volumes for radiosurgery using the angiographic and CT data. Materials and methods: The basis of this new ... [more ▼]

Abstract Background and purpose: This work was undertaken to improve the definition of target volumes for radiosurgery using the angiographic and CT data. Materials and methods: The basis of this new method is to combine both imaging modalities and to compare them in each representation, i.e. to plot the volume obtained by angiography on CT images and also the contours defined by the CT on angiographic films. To obtain the angiographic volume, the radiographs are taken at several incidence angles. The X-ray sources position and the position of the films are determined using rectangular markers, then the intersection of all the loci of the target volume are calculated. Results: Verifications with a phantom show the accuracy of the procedure and the benefit obtained by increasing the number of angles of incidence in the angiographic imaging. The centre of gravity of the experimental target could be localized to an accuracy of better than 0.4 mm. The method was used in 11 clinical cases with excellent clinical results. Conclusions: The method can be easily applied and improves the delineation of target volumes in radiosurgery. CT data counterbalances the relative weakness of angiography concerning the three-dimensional geometry. Angiography adds useful information on the blood flow that is not shown in CT. Almost all the presented clinical cases benefit from the technique described here. [less ▲]

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See detailClostridium spiroforme toxin genes are related to C. perfringens iota toxin genes but have a different genomic localization.
Gilbert, M.; Perelle, S.; Daube, Georges ULg et al

in Systematic & Applied Microbiology (1997), 20

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See detailSIME: A hybrid approach to fast transient stability assessment and contingency selection
Zhang, Ywee; Wehenkel, Louis ULg; Rousseaux, Patricia ULg et al

in International Journal of Electrical Power & Energy Systems (1997), 19(3), 195-208

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME ... [more ▼]

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME for Single Machine Equivalent. SIME relies on a particular direct method coupled with time-domain programs so as to combine the strengths of both, namely: the flexibility with respect to power system modelling of time-domain methods; the speed and richer information of the direct method. This paper lays the foundations of SIME, devises appropriate techniques for transient stability assessment per se and for contingency screening, and finally integrates these two techniques in a fully general function, i.e. able to comply with any power system modelling and stability scenario, and to assess any type of stability limits (critical clearing times or power limits). Throughout, real-world examples illustrate the proposed techniques and highlight their performances. [less ▲]

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See detailCompactly supported wavelets in Sobolev spaces of integer order
Bastin, Françoise ULg; Laubin, P.

in Applied & Computational Harmonic Analysis (1997), 4(1), 51-57

We present a construction of regular compactly supported wavelets in any Sobolev space of integer order. It is based on the existence and suitable estimates of filters defined from polynomial equations ... [more ▼]

We present a construction of regular compactly supported wavelets in any Sobolev space of integer order. It is based on the existence and suitable estimates of filters defined from polynomial equations. We give an implicit study of these filters and use the results obtained to construct scaling functions leading to multiresolution analysis and wavelets. Their regularity increases linearly with the length of their supports as in the L(2) case. One technical problem is to prove that the intersection of the scaling spaces is reduced to 0. This is solved using sharp estimates of Littlewood-Paley type. (C) 1997 Academic Press, Inc. [less ▲]

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See detailProgesterone receptors (PR) in ectopic endometrium?
NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (1997), 68(5), 943-4

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See detailSpecific repertoire of olfactory receptor genes in the male germ cells of several mammalian species
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Genomics (1997), 39

Olfactory receptors constitute the largest family among G protein-coupled receptors, with up to 1000 members expected. We have previously shown that genes belonging to this family were expressed in the ... [more ▼]

Olfactory receptors constitute the largest family among G protein-coupled receptors, with up to 1000 members expected. We have previously shown that genes belonging to this family were expressed in the male germ line from both dog and human. We have subsequently demonstrated the presence of one of the corresponding olfactory receptor proteins during dog spermatogenesis and in mature sperm cells. In this study, we investigated whether the unexpected pattern of expression of olfactory receptors in the male germ line was conserved in other mammalian species. Using reverse transcription-PCR with primers specific for the olfactory receptor gene family, about 20 olfactory receptor cDNA fragments were cloned from the testis of each mammalian species tested. As a whole, they displayed no sequence specificity compared to other olfactory receptors, but highly homologous, possibly orthologous, genes were amplified from different species. Finally, their pattern of expression, as determined by RNase protection assay, revealed that many but not all of these receptors were expressed predominantly in testis. The male germ line from each mammalian species tested ins thus characterized by a specific repertoire of olfactory receptors, which display a pattern of expression suggestive of their potential implication in the control of sperm maturation, migration, or fertilization [less ▲]

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See detailLe maintien des droits aux prestations de santé lors d'une séparation de fait ou de corps
Michiels, Olivier ULg

in Divorce : Actualité Juridique, Sociale et Fiscale (1997)

L'article examine la question du maintien des droits aux prestations de santé lors d'une séparation de corps ou d'une séparation de fait.

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See detailEvaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways
Duvivier, Dominique Hannia; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Veterinary Research (1997), 28(6), 557-564

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M ... [more ▼]

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M). The in vitro inhalation study was performed using the cascade impaction method (Andersen Sampler) adapted to imitate nasal breathing. The amount of ipratropium found in the device, the artificial upper airways and the six stages of the Andersen Sampler was measured using high precision liquid chromatography. Stage 1 of the Andersen Sampler was considered to be the respirable fraction and stages 2 to 6 to be the non-respirable fraction. It was concluded that the theoretical respirable fraction of ipratropium obtained after DPI through Inhalator M was influenced by relative air humidity, air flow and the position of the device, whereas the number of successive inspirations and the duration of inspiration did not affect this fraction of the drug. [less ▲]

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See detailDifferential expression of c-fos, Hsp70 and Hsp27 after photothrombotic injury in the rat brain.
Plumier, Jean-Christophe ULg; Armstrong, J. N.; Wood, N. I. et al

in Molecular Brain Research (1997), 45(2), 239-46

In situ hybridization and immunohistochemistry were used to examine the expression of c-fos, Hsp70 and Hsp27 following photothrombotic injury in the right fronto-parietal cortex of the rat. C-fos mRNA and ... [more ▼]

In situ hybridization and immunohistochemistry were used to examine the expression of c-fos, Hsp70 and Hsp27 following photothrombotic injury in the right fronto-parietal cortex of the rat. C-fos mRNA and protein were detected in the entire cerebral cortex on the lesioned side. Hsp70 mRNA accumulation was observed only adjacent and peripheral to the site of the lesion. At 1 h after photothrombotic injury, Hsp70 expression delineates the area of necrosis at 24 h after photothrombotic injury. Hsp27 protein was observed in the ipsilateral cerebral cortex with the exception of the deep layers of the cingulate cortex. In addition, while c-Fos immunoreactivity was localized in cell nuclei, Hsp27 immunoreactivity was detected in the cytoplasm of astrocytes. These results demonstrate that unilateral cortical injury induces changes in gene expression that vary according to cell type and brain region. [less ▲]

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See detailIn vivo behavior of poly(D,L)-lactide microspheres designed for chemoembolization
Flandroy, P.; Grandfils, Christian ULg; Danen, B. et al

in Journal of Controlled Release (1997), 44(2-3), 153-170

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is ... [more ▼]

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is limited by the lack of appropriate and reliable embolization materials. Recently, calibrated microspheres of poly(D,L)-lactide have proved to be promising in embolization. Nevertheless, repetitive chemoembolization requires the availability of microspheres degradable within a few days. For this purpose, microspheres consisting of a blend of two polyesters of a very different molecular weight (Mn =65 000 and 3500 in a 16:84 wt. ratio) have been prepared and injected in the renal arteries of rabbits. The in vivo fate of these two component microspheres has been compared by radiology and histology to microspheres prepared from the high molecular weight poly(D,L)-lactide. Furthermore, the in vivo degradation of the polymer has been measured by size exclusion chromatography after quantitative reextraction from the embolized kidney. Degradation kinetics has been compared to data previously reported in vitro. According to the observations performed during the in vivo study, the 50/50 microspheres appear more useful for the chemoembolization of tumors. [less ▲]

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See detailMecanisme de croissance et de rupture des anevrysmes de l'aorte abdominale.
Limet, Raymond ULg; SakalihasanN, Natzi ULg; Lapiere, C. M.

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1997), 152(7-9), 295-302302-3

The relationship between atherosclerosis and abdominal aortic aneurysm development is well known. Atherosclerosis cannot explain the whole mechanism. Genetic characters of mechanisms leading to abdominal ... [more ▼]

The relationship between atherosclerosis and abdominal aortic aneurysm development is well known. Atherosclerosis cannot explain the whole mechanism. Genetic characters of mechanisms leading to abdominal aortic development is obvious from this study and others. Our study evidences an increased metalloproteases activity in aortic wall proportionally to the size of the abdominal aortic aneurysm. A decrease of aortic wall elastin is evidenced proportionally to the AAA size. Extractable collagen is significantly increased in the aortic wall of patients operated on for aortic rupture. [less ▲]

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See detailPolyclonal Bovine Sera But Not Virus-Neutralizing Monoclonal Antibodies Block Bovine Leukemia Virus (Blv) Gp51 Binding To Recombinant Blv Receptor Blvrcp1
Orlik, O.; Ban, J.; Hlavaty, J. et al

in Journal of Virology (1997), 71(4),

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See detailFunctional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle.
GOTHOT, André ULg; Pyatt, R.; McMahel, J. et al

in Blood (1997), 90(11), 4384-93

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the ... [more ▼]

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34(+) cells were isolated in subcompartments of the G0 /G1 phase of the cell cycle by flow cytometric cell sorting. In both bone marrow (BM) and mobilized peripheral blood (MPB) CD34(+) cells, primitive long-term hematopoietic culture-initiating cell (LTHC-IC) activity was higher in CD34(+) cells isolated in G0 (G0CD34(+) cells) than in those residing in G1 (G1CD34(+) cells). However, as MPB CD34(+) cells displayed a more homogeneous cell-cycle status within the G0 /G1 phase and a relative absence of cells in late G1 , DNA/RNA fractionation was less effective in segregating LTHC-IC in MPB than in BM. BM CD34(+) cells belonging to four subcompartments of increasing RNA content within the G0 /G1 phase were evaluated in functional assays. The persistence of CD34 expression in suspension culture was inversely correlated with the initial RNA content of test cells. Multipotential progenitors were present in G0 or early G1 subcompartments, while lineage-restricted granulomonocytic progenitors were more abundant in late G1 . In vitro hematopoiesis was maintained for up to 6 weeks with G0CD34(+) cells, whereas production of clonogenic progenitors was more limited in cultures initiated with G1CD34(+) cells. To test the hypothesis that primitive LTHC-ICs would reenter a state of relative quiescence after in vitro division, BM CD34(+) cells proliferating in ex vivo cultures were identified from their quiescent counterparts by a relative loss of membrane intercalating dye PKH2, and were further fractionated with Hst and PY. The same functional hierarchy was documented within the PKH2(dim) population whereby LTHC-IC frequency was higher for CD34(+) cells reselected in G0 after in vitro division than for CD34(+) cells reisolated in G1 or in S/G2 + M. However, the highest LTHC-IC frequency was found in quiescent PKH2(bright) CD34(+) cells. Together, these results support the concept that cells with distinct hematopoietic capabilities follow different pathways during the G0 /G1 phase of the cell cycle both in vivo and during ex vivo culture. [less ▲]

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See detailLong term follow-up of patients with acute myelogenous leukemia who received the daunorubicin, vincristine, and cytosine arabinoside regimen.
Beguin, Yves ULg; Sautois, Brieuc ULg; Forget, Patricia ULg et al

in Cancer (1997), 79(7), 1351-4

BACKGROUND: In 1985, the authors published a study of acute myelogenous leukemia (AML) patients treated with a chemotherapeutic regimen that was then considered intensive. Ten years later, the authors ... [more ▼]

BACKGROUND: In 1985, the authors published a study of acute myelogenous leukemia (AML) patients treated with a chemotherapeutic regimen that was then considered intensive. Ten years later, the authors reanalyzed the same cohort to determine whether the very promising actuarial results observed at 5 years held after longer follow-up. METHODS: Between 1977 and 1982, 61 patients with AML were treated with a protocol consisting of daunorubicin, vincristine, and cytosine arabinoside induction followed by consolidation and maintenance for a total of 2 years. The complete remission (CR) rate was 66%, 84% in males versus 47% in females (P < 0.005). At the time of the first analysis in 1984, the overall survival (OS) was 17%, the projected 5-year continuous CR rate (CCR) 32%, and the disease free survival (DFS) rate 29%, with the best results observed for males and for patients ages 40-60 years (P < 0.05). RESULTS: When the data were reanalyzed 11 years later in 1995, the results were 14% OS, 23% CCR, and 16% DFS at 5 years. However, these figures dropped to 8%, 18%, and 11% at 10 years and to 8%, 12%, and 7% at 15 years, respectively. Among the 40 CR patients, 31 relapsed (up to 13 years after CR), and all died within 1.6 years after relapse. Nine patients were in CCR: 4 died of unrelated causes (suicide, alcoholic cirrhosis, acute peritonitis, or bladder carcinoma), 1 was lost to follow-up after 11 years, 2 were alive and well at 17 years at last follow-up, and 2 were transplanted in first CR and were doing well at 13 and 14 years at last follow-up. The survival advantage for males over females persisted (P = 0.0197), but the advantage for patients age 40-60 years did not hold. CONCLUSIONS: These long term data indicate that actuarial analysis at 5 years may overestimate the cure rate of AML patients because a number of late relapses do occur. However, the picture is blurred by the incidence of death not related to leukemia or its treatment; and when these patients were censored at the time of death, 17% of CR patients were still projected to be alive and free of leukemia after 17 years. [less ▲]

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See detailComparison of results of carotid artery surgery after either direct closure or use of a vein patch.
Desiron, Quentin ULg; Detry, Olivier ULg; Van Damme, Hendrik ULg et al

in Cardiovascular Surgery (1997), 5(3), 295-303

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting ... [more ▼]

In order to assess the benefit of vein patching versus direct closure after carotid endarterectomy, a series of 2271 carotid operations were analysed retrospectively. Apart from 114 procedures consisting of saphenous vein bypass (n = 29) and eversion endarterectomy (n = 85), 2157 open endarterectomies were performed. They were closed either directly (n = 837) or using a vein patch (n = 1320). The combined mortality-major neurological morbidity rate was 1.7%, i.e. 1% mortality (0.2% neurological) and 0.7% permanent neurological morbidity (0.5% ipsilateral to the operated artery). Early symptomatic internal carotid thrombosis was documented in six cases (four following direct closure and two after vein patching). A total of 827 carotid arteries were followed up by duplex scanning on an annual basis (244 direct closure and 583 vein patching). The mean follow-up was 44 months; 69 months for direct closure and 35 months for vein patching. In direct closure, there were 21 stenoses (9%) and 10 occult thromboses (4%); in vein patching carotids, there were 17 stenoses (3%), nine thromboses (1.8%) [corrected] and six pseudoaneurysms (1%). Annual incidence of poor results was 2.4% in direct closure, and 0.87% in vein patching. The only other factor responsible for a significant difference was gender (3.4% in women versus 2.1% in men). In this retrospective study, vein patching appears to be beneficial for the prevention of acute postoperative thrombosis and late stenosis or thrombosis. [less ▲]

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See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailUne étude du style de vie de jeunes dans l’Union Européenne. Qu’en conclure et quels enseignements en tirer?
Piéron, Maurice; Ledent, Maryse; Delfosse, Catherine et al

in Sport (1997), 159/160

La littérature internationale continue à rassembler des indices en nombre croissant montrant l'étroite relation entre l'état de santé et la condition physique. Toutefois, une évolution très nette se ... [more ▼]

La littérature internationale continue à rassembler des indices en nombre croissant montrant l'étroite relation entre l'état de santé et la condition physique. Toutefois, une évolution très nette se marque dans l'identification des déterminants importants. La condition physique apparaît comme un produit très transitoire qui se détériore à partir du moment où l'on cesse de l'entretenir. ... [less ▲]

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See detailGenetic markers may predict disease behavior in patients with ulcerative colitis.
Roussomoustakaki, M.; Satsangi, J.; Welsh, K. et al

in Gastroenterology (1997), 112(6), 1845-53

BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The ... [more ▼]

BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The aim of this study was to test these hypotheses in patients undergoing surgery for their colitis. METHODS: HLA DRB1 and DQB1 genotyping was performed in 99 patients and 472 controls. Genotyping for polymorphisms of genes encoding tumor necrosis factor alpha and IL-1RA was performed in 107 patients and 89 controls. Measurement of antineutrophil cytoplasmic antibody (ANCA) was performed in 72 patients and 58 healthy subjects by fixed neutrophil enzyme-linked immunosorbent assay and indirect immunofluorescence. RESULTS: The DRB1*0103 allele was increased in patients (14.1% vs. 3.2% in controls; P < 1 x 10[-5]). This association was greatest in patients with extensive disease (15.8%; P < 0.0001) or extraintestinal manifestations (22.8%; P < 0.0001): mouth ulcers (25.8%; P < 0.0001), arthritis (27.2%; P < 0.0001), and uveitis (35.7%; P < 0.0001). The DRB1*04 alleles were reduced in patients (P = 0.005). Differences were noted between extensive and distal disease in the frequency of allele 2 of IL-1RA (10.9% in distal vs. 28.6% in extensive; P = 0.01) and allele 2 homozygosity. ANCA was detected in 76.4% of patients. Carriage of IL-1RA allele 2 and tumor necrosis factor 2 allele was increased in ANCA-positive patients. CONCLUSIONS: Genetic markers may predict disease behavior in ulcerative colitis. [less ▲]

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See detailSite-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies.
Guillaume, Gilliane; Vanhove, M; Lamotte-Brasseur, J et al

in Journal of Biological Chemistry (1997), 272(9), 5438-44

The catalytic pathway of class A beta-lactamases involves an acyl-enzyme intermediate where the substrate is ester-linked to the Ser-70 residue. Glu-166 and Lys-73 have been proposed as candidates for the ... [more ▼]

The catalytic pathway of class A beta-lactamases involves an acyl-enzyme intermediate where the substrate is ester-linked to the Ser-70 residue. Glu-166 and Lys-73 have been proposed as candidates for the role of general base in the activation of the serine OH group. The replacement of Glu-166 by an asparagine in the TEM-1 and by a histidine in the Streptomyces albus G beta-lactamases yielded enzymes forming stable acyl-enzymes with beta-lactam antibiotics. Although acylation of the modified proteins by benzylpenicillin remained relatively fast, it was significantly impaired when compared to that observed with the wild-type enzyme. Moreover, the E166N substitution resulted in a spectacular modification of the substrate profile much larger than that described for other mutations of Omega-loop residues. Molecular modeling studies indicate that the displacement of the catalytic water molecule can be related to this observation. These results confirm the crucial roles of Glu-166 and of the "catalytic" water molecule in both the acylation and the deacylation processes. [less ▲]

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See detailThe meaning of formal: from weak to strong formal methods
Wolper, Pierre ULg

in International Journal on Software Tools for Technology Transfer (1997), 1(1-2), 6--8

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See detailThe Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Research Communications (1997), 21(7), 521-531

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet ... [more ▼]

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable. [less ▲]

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See detailUsefulness of Induced Sputum Analysis in Pulmonary Diseases
Kayembe, J. M.; Louis, Renaud ULg; Corhay, Jean-Louis ULg et al

in Acta Clinica Belgica (1997), 52(2), 106-11

In this study, we analysed the cellular component of induced sputum in healthy control subjects (n = 30), asthmatics (n = 44), patients suffering from COPD (n = 15), pulmonary tuberculosis (PTB) (n = 14 ... [more ▼]

In this study, we analysed the cellular component of induced sputum in healthy control subjects (n = 30), asthmatics (n = 44), patients suffering from COPD (n = 15), pulmonary tuberculosis (PTB) (n = 14) and healthy steel workers (HSW) (n = 14). [less ▲]

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See detailMulticité. Le jeu du développement urbain
Beckers, Jacqueline ULg; Demeuse, Yves; Merenne-Schoumaker, Bernadette ULg et al

in G.E.O. (1997), 41(Numéro spécial),

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la ... [more ▼]

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la maximisation des retombées pour la collectivité ; elle fait appel à des bureaux d’études qui doivent monter ces projets. Le jeu se joue sur un territoire (plateau de jeu) avec ses quartiers d’habitat, son centre, ses réseaux de communication et aussi 350 îlots colorés selon l’affectation du sol et leur statut (public et privé). Le jeu – qui se déroule aussi sur deux fois 50 minutes dans sa version courte (un projet) – permet d’abord à l’équipe municipale de définir ses critères de choix et aux bureaux d’étude de monter leur projet, il met ensuite les protagonistes en contact puis en débat avant le choix final. Outre le plateau figurant le territoire, le jeu comprend encore des fiches relatives aux équipements, des consignes particulières pour les membres du bureau d’études et de l’équipe municipale (dont une fiche budget et une fiche argumentaire). À l’issue du jeu, il est possible non seulement de mettre en évidence les facteurs de localisation des équipements mais également le jeu des acteurs et les contraintes d’une politique de développement communal. [less ▲]

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