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See detailDe l'enseignement à l'apprentissage : le paradigme cognitif en didactique des langues
Defays, Jean-Marc ULiege

in Revue Parole (2005), 34-35-36

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See detailPeach latent mosaic viroid detected for the firts time on almond trees in Tunisia
Fekih Hassen, I.; Roussel, S.; Kummert, J. et al

in Plant Disease (2005), 89

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See detailMOTOR UNIT INVOLVEMENT IN PLS, ALS AND KENNEDY’S DISEASE
WANG, François-Charles ULiege; Le Forestier, Nadine; GERARD, Pascale ULiege et al

in Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders (2005)

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See detailBeak Trimming
Marlier, Didier ULiege

in Veterinary Journal (2005), 170

To trim or not to trim beaks? It is always a good time to raise this difficult question. Indeed, since the release of the Brambell Committee report1 on welfare in the UK in 1965, discussion on the welfare ... [more ▼]

To trim or not to trim beaks? It is always a good time to raise this difficult question. Indeed, since the release of the Brambell Committee report1 on welfare in the UK in 1965, discussion on the welfare of beak-trimmed birds has continued unabated. The aim of this new book (with its 15 contributors) is not, of course, to close the debate but merely to consolidate the huge amount of scientific information available on methods welfare and alternatives to beak-trimming. In the Preface, it is stated that the book will be of interest to welfare groups, policy makers, scientists, industry leaders and students of poultry science who wish to acquaint themselves with the welfare issues associated with beak-trimming and the potential solutions for reducing the need to beak-trim poultry. This goal is achieved to the extent that most of the information (although sometimes rather concisely) is presented in the eight chapters of this 174 page book. The first chapter describes the methods and reasons for beak-trimming. Chapter 2 raises the ethical question of beak-trimming and gives some of the pros and cons of the arguments. Pain and nerve injuries induced by beak-trimming are presented in Chapters 3–5 and the production responses (improved liveability, plumage quality and feed efficiency during egg laying) of beak-trimmed birds are assessed in Chapter 6 with bird health and handling issues associated with beak-trimming in Chapter 7. The last chapter is devoted to alternatives to beak-trimming. It includes environmental enrichment methods; a consideration of the genetics of feather pecking and cannibalism; dietary recommendations to reduce cannibalism in chickens and laying hens; manipulation of light intensities and colour to modify behaviour; management of body weight; application of abrasive strips in the feed trough to blunt the tips of the beaks of laying hens and the use of fitted devices and stock wound spray in injured birds to prevent further pecking. Among all these alternatives, the genetic solution might well prove to be the most sustainable, efficacious and cost effective. Overall, however, throughout the book this reviewer had the feeling, rightly or wrongly, that it was mostly written by opponents of beak-trimming and that arguments of the defence were sometimes omitted. [less ▲]

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See detailAbout the Rectilinear Keplerian Motion
Condurache, D.; Martinusi, Vladimir ULiege

in Bulletin of the Polytechnic Institute of Jasi. Section Mathematics, Theoretical Mechanics, Physics = Buletinul Institutului Politehnic din Iaşi. Secţia Matematica, Mecanica Teoretica, Fizica (2005)

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See detailApplication of PIXE and PIGE under variable ion beam incident angle to several fields of archaeometry
Weber, Georges ULiege; Martinot, L.; Strivay, David ULiege et al

in X-Ray Spectrometry [=XRS] (2005), 34(4, JUL-AUG), 297-300

For several years, the specific features of PIXE and PIGE have made them very attractive in the field of archaeometry. Among them, non-destructivity is one of the most important. The possibility of ... [more ▼]

For several years, the specific features of PIXE and PIGE have made them very attractive in the field of archaeometry. Among them, non-destructivity is one of the most important. The possibility of working under atmospheric pressure is also important because of the very different shapes and sizes of the artefacts concerned. However, these ion beam techniques suffer from the same disadvantage: the information coming from x-rays or),brays produced at different places along the charged particle path is integrated. That prevents one from taking into account the possible element concentration gradients due to multilayered systems or diffusion processes. This paper presents several applications of PIXE and PIGE applied under variable ion beam incident angle. PIGE has been mainly used for studying ancient glass items or glass windows in order to detect or evaluate the glass corrosion process. The examples given for PIGE deal with Roman and Merovingian glass objects and cathedral glass windows and PIXE applications concern studies for resolving the multilayered structure of easel paintings. The set-up allowing one to perform the measurements should be very stable, the rotation axis should pass through the beam axis and the detector should follow the sample movement. Copyright (c) 2005 John Wiley [less ▲]

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See detailOù va la critique scientifique?
Defays, Jean-Marc ULiege

in Parole (2005), 33

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See detailCost-effectiveness analysis applied to the veterinary medicine: The economic value of packed cell value in the prognosis of horse surgical colic
Detilleux, Johann ULiege; Serteyn, Didier ULiege

in International Journal of Applied Research in Veterinary Medicine (2005), 3(4), 309-318

Techniques of cost-effectiveness analyses were applied to determine whether or not it is economically efficient to measure the packed cell volume (PCV) on a colic horse before deciding on abdominal ... [more ▼]

Techniques of cost-effectiveness analyses were applied to determine whether or not it is economically efficient to measure the packed cell volume (PCV) on a colic horse before deciding on abdominal surgery. The effects of this decision of uncertainty on the estimated values of the parameters (probability of survival after surgery, surgery costs, PCV positive predictive value, and length of survival after surgery) were considered along with the monetary values of collecting additional information on those parameters. The effects of uncertainty on the incremental net benefits of each alternative were depicted by tornado diagrams, cost-effectiveness acceptability curves, and posterior probability distributions. The worth of additional information was computed as the expected values of perfect and sampling information. Given previously published results, the best PCV cut-off point to distinguish between survivors and nonsurvivors was at 44%. At this threshold, the most economically effective alternative is to measure PCV before surgery providing the owner is willing to pay less than €672 for each year the horse survives. Uncertainty on probability of survival after surgery largely influenced the decision whether or not to measure the PCV, but one should spend at most €381 in research to reduce this uncertainty. A study of postoperative survival of 500 colic horses would ensure an expected gain of €370 associated with a reduction in uncertainty. [less ▲]

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See detailThird metacarpal bone mineral density assessment in the standing horse by dual X-ray absorptiometry - Suitability, precision and accuracy
Donabedian, M.; Delguste, Catherine ULiege; Perona, G. et al

in Veterinary and Comparative Orthopaedics and Traumatology (2005), 18(1), 26-30

Bone mineral density (BMD) is correlated to mechanical properties of bone. In the horse, dual energy X-ray absorptiometry (DXA) has yet only been performed ex-vivo, but a new portable DXA device would be ... [more ▼]

Bone mineral density (BMD) is correlated to mechanical properties of bone. In the horse, dual energy X-ray absorptiometry (DXA) has yet only been performed ex-vivo, but a new portable DXA device would be ideal for in-vivo BMD measurement. We explored field suitability, precision and accuracy of this device for in-vivo third metacarpal density assessment. Precision was analysed by calculating measurement variation under repeated measurement tests with (reproducibility) and without (repeatability) limb repositioning. Repeatability and reproducibility were tested ex-vivo, at the some time that intra- and inter-operator reproducibility were assessed in-vivo. In order to test accuracy, bone mineral content (BMC) of several bone samples determined by DXA and ashing were compared. Repeatability was 1.47% and reproducibility 1.69% ex-vivo. In-vivo reproducibility varied between 2.91 and 4.06% for intraoperator test and between 3.13 and 5.53% for interoperator test. BMC measured by DXA and ash weight were highly correlated (R-2 > 0.99). In conclusion, under described conditions this DXA device is usable, accurate and precise. Its sensitiveness reaches 8.23% in an individual longitudinal monitoring. Using the third metacarpal bone as an example, we have shown that this device is suitable for experimental or clinical monitoring. [less ▲]

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See detailReduced cell turnover in lymphocytic monkeys infected by human T-lymphotropic virus type 1.
Debacq, Christophe; Heraud, Jean-Michel; Asquith, Becca et al

in Oncogene (2005), 24(51), 7514-23

Understanding cell dynamics in animal models have implications for therapeutic strategies elaborated against leukemia in human. Quantification of the cell turnover in closely related primate systems is ... [more ▼]

Understanding cell dynamics in animal models have implications for therapeutic strategies elaborated against leukemia in human. Quantification of the cell turnover in closely related primate systems is particularly important for rare and aggressive forms of human cancers, such as adult T-cell leukemia. For this purpose, we have measured the death and proliferation rates of the CD4+ T lymphocyte population in squirrel monkeys (Saimiri sciureus) infected by human T-lymphotropic virus type 1 (HTLV-1). The kinetics of in vivo bromodeoxyuridine labeling revealed no modulation of the cell turnover in HTLV-1-infected monkeys with normal CD4 cell counts. In contrast, a substantial decrease in the proliferation rate of the CD4+ T population was observed in lymphocytic monkeys (e.g. characterized by excessive proportions of CD4+ T lymphocytes and by the presence of abnormal flower-like cells). Unexpectedly, onset of HTLV-associated leukemia thus occurs in the absence of increased CD4+ T-cell proliferation. This dynamics significantly differs from the generalized activation of the T-cell turnover induced by other primate lymphotropic viruses like HIV and SIV. [less ▲]

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See detailMemory for temporal context : Effects of aging, encoding instructions and retrieval strategies
Bastin, Christine ULiege; Van der Linden, Martial ULiege

in Memory (2005), 13(1), 95-109

Young and older adults were compared on a list discrimination task. In Experiment 1, performance declined with aging after incidental and intentional encoding of the temporal context. Moreover, there was ... [more ▼]

Young and older adults were compared on a list discrimination task. In Experiment 1, performance declined with aging after incidental and intentional encoding of the temporal context. Moreover, there was no benefit for intentional encoding in either group. In Experiment 2, each list was associated with a different encoding context. There were age differences in performance when participants tried to retrieve the encoding context of the items as a cue for their list of occurrence, but not when participants evaluated temporal distance from the strength of the memory trace. This suggests that the age-related decrease in list discrimination could be at least partly due to a difficulty to infer strategically the temporal context of the items from information encoded in the same time. [less ▲]

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See detailCheveux et risques environnementaux.
Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Skin (2005), 8

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See detailDe vraies sanctions administratives ou des sanctions pénales camouflées? Réflexions en droit interne belge.
Masset, Adrien ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2005), (4), 441-466

L’expérience belge des sanctions administratives, examinée au travers de plusieurs exemples, est considérée comme assez riche pour voir venu le temps de s’atteler à la rédaction d’une véritable théorie ... [more ▼]

L’expérience belge des sanctions administratives, examinée au travers de plusieurs exemples, est considérée comme assez riche pour voir venu le temps de s’atteler à la rédaction d’une véritable théorie, active et critique, des sanctions administratives [less ▲]

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See detailTsunami en Asie du Sud-Est : analyse de son importance dans la presse écrite, des coûts assurés et du nombre de victimes à Sumatra
De Longueville, Florence ULiege; Ozer, Pierre ULiege

in Bulletin de la Société Géographique de Liège (2005), 46

The tsunami that affected the Indian ocean’s rims on December 26, 2004 claimed close to 300 000 deaths, essentially on the island of Sumatra, Indonesia, which suffered overwhelming devastation. This ... [more ▼]

The tsunami that affected the Indian ocean’s rims on December 26, 2004 claimed close to 300 000 deaths, essentially on the island of Sumatra, Indonesia, which suffered overwhelming devastation. This article is focused on three specific aspects of the disaster. On one side, we analyse the tribune offered to the tsunami catastrophe by the press in Le Soir and Le Monde. On the other side, we present an analysis of the distribution of insured losses from the latest data made available by the two largest reinsurance world companies, Swiss Re and Munich Re. Finally, we try to compare the estimated death toll with available demographic data for the province of Aceh. Here we show that the place given to the tsunami is enormous when compared to other natural tragedies, and we try to explain what motivated such a coverage. In addition, the analysis of insured losses highlights the North-South differences as local victims (99 %) concentrate less than 10 % of the losses supported by insurers. For what regards the death toll, we conclude that the number of about 235 000 for northern Indonesia is a broad estimation and that a realistic approach is impossible since no census was made in this region over the last three decades. [less ▲]

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See detailFracture prevention in postmenopausal women
Bruyère, Olivier ULiege; Edwards, John; Reginster, Jean-Yves ULiege

in Clinical Evidence (2005), 13

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See detailAeolian dust falls in northern Italy in autumn 1996: chemical and mineralogical comparison
Ozer, Pierre ULiege; LUCCHETTI, Gabriella

in Periodico di Mineralogia (2005), 74(2), 103-116

This paper describes two dust fall events in Genoa and Turin (northern Italy) on 12 November 1996 and 7 December 1996 respectively. Meteorological data suggest that the dust-bearing rain that fell on ... [more ▼]

This paper describes two dust fall events in Genoa and Turin (northern Italy) on 12 November 1996 and 7 December 1996 respectively. Meteorological data suggest that the dust-bearing rain that fell on Genoa originated in north-eastern Morocco, where dust mobilisation was reported two days earlier, and had been carried straight to the north-western Italian coast by very strong winds. But the dust fall observed in Turin was not characterised by any specific synoptic situation inducing dust transport from the southern Mediterranean. The analyses include a quantitative and a qualitative study of two dust samples collected in downtown Genoa and Turin. The total amounts of dust that fell give two very high values of 4.05 g m-2 for Genoa and 0.54 g m-2 for Turin. The median sizes of the dust particles were 14.6 µm and 25.8 µm respectively. Most of the dust material collected in Genoa showed a yellowish-brown to red colour due to surface weathering by ferric hydroxides, and was sometimes coated with clayey particles. This attests to the Saharan origin of the particles. On the contrary, only 15% of the material sampled in Turin was coated with red-like clayey material from the desert. A large part of the sample was covered with a carbon-like substance. In addition, the proportion of organic matter (pollen grains and seeds) and anthropogenic fibrous material was much higher. This suggests that the dust fall observed in Turin very likely originated from local pollution mixed with a low proportion of long-distance Saharan dust. [less ▲]

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See detailBEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.
Smit, Maria A; Tordoir, Xavier ULiege; Gyapay, Gabor et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (2005), 16(10), 801-14

In this article we describe the organization of the ovine BEGAIN gene, located 138 kb proximally from the imprinted DLK1 gene and 203 kb from the CLPG mutation that causes the callipyge phenotype. We have ... [more ▼]

In this article we describe the organization of the ovine BEGAIN gene, located 138 kb proximally from the imprinted DLK1 gene and 203 kb from the CLPG mutation that causes the callipyge phenotype. We have shown that in sheep BEGAIN is ubiquitously expressed, including in skeletal muscle, throughout development. We have identified four major BEGAIN transcripts resulting from a combination of alternate promoter usage and alternative splicing. In ovine brain, kidney, liver, and skeletal muscle, these four BEGAIN transcripts exhibited paternal or biallelic expression in a tissue- and promoter-specific manner. Our results indicate that the CLPG mutation does not alter transcript levels of BEGAIN, contrary to its effect on a core cluster of genes in the DLK1-GTL2 domain. Thus, although the BEGAIN gene represents another paternally expressed gene in the ovine DLK1-GTL2 imprinted domain, its expression is not governed by the long-range regulatory element that contains the CLPG mutation. [less ▲]

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See detailUn mecanisme physiopathologique central a l'origine des complications du diabete?
Defraigne, Jean-Olivier ULiege

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 472-8

Diabetes mellitus is associated to micro- and macro-vascular lesions responsible for myocardial infarction, nephropathy, retinopathy and polyneuropathy. Four main pathogenic mechanisms have been proposed ... [more ▼]

Diabetes mellitus is associated to micro- and macro-vascular lesions responsible for myocardial infarction, nephropathy, retinopathy and polyneuropathy. Four main pathogenic mechanisms have been proposed, all associated with hyperglycaemia: 1) increased flux in the polyol pathway; 2) increased flux in the hexosamine pathway; 3) protein kinase C activation; and 4) increased formation of advanced glycation endproducts. A common mechanism seems to play a central role in the activation of these various pathways. Indeed, an increased production of free radicals by mitochondria induced by hyperglycaemia may be responsible for the observed metabolic disturbances. The present article describes that theory and presents its possible therapeutic implications. [less ▲]

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See detailParentification-infantilisation: le processus d'individuation de la mère d'Anne
Dessoy, Etienne; Stassart, Martine ULiege; Courtois, A., Anne et al

in Thérapie Familiale (2005), 26(1), 37-53

Summary: Parentification – infantilization. The individuation process of Anne’s mother. – The research on the double bind context helps us understand the individuation process of mothers who are described ... [more ▼]

Summary: Parentification – infantilization. The individuation process of Anne’s mother. – The research on the double bind context helps us understand the individuation process of mothers who are described as parentified and whose child seems to present borderline or psychotic problems. In a previous paper, we presented a study on double bind between those mothers and their child. This aim of this present paper is to develop the transgenerational aspects of those family patterns. The paper will describe the individuation process of the parentifed mother based on the position she had in her own family, the way she grew up and progressively developed. We will examine her functions towards each of her parents and as well as towards her sibling. We will focus on different elements such as contact style, patterns of interaction in the creation of an «experiencing world» that is so crucial in double bind process. This paper is the last of four. Their all tried to expand the area of double bind by clarifyinging the Bateson’s metaphor about the double bind as the only visible part of an iceberg. Further than a logical conceptual organization for double bind patterns, the aim of this paper is to provide therapists with a methodological tool they could use as a map which is co-created with the family to progressively reveal the good reasons for this pathological situation to be and question its pertinence in the family today. [less ▲]

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See detailFate of premalignant clones during the asymptomatic phase preceding lymphoid malignancy.
Moules, Vincent; Pomier, Carole; Sibon, David et al

in Cancer Research (2005), 65(4), 1234-43

Almost all cancers are preceded by a prolonged period of clinical latency during which a combination of cellular events helps move carcinogen-exposed cells towards a malignant phenotype. Hitherto ... [more ▼]

Almost all cancers are preceded by a prolonged period of clinical latency during which a combination of cellular events helps move carcinogen-exposed cells towards a malignant phenotype. Hitherto, investigating the fate of premalignant cells in vivo remained strongly hampered by the fact that these cells are usually indistinguishable from their normal counterparts. Here, for the first time, we have designed a strategy able to reconstitute the replicative history of the bona fide premalignant clone in an animal model, the sheep experimentally infected with the lymphotropic bovine leukemia virus. We have shown that premalignant clones are early and clearly distinguished from other virus-exposed cells on the basis of their degree of clonal expansion and genetic instability. Detectable as early as 0.5 month after the beginning of virus exposure, premalignant cells displayed a two-step pattern of extensive clonal expansion together with a mutation load approximately 6 times higher than that of other virus-exposed cells that remained untransformed during the life span of investigated animals. There was no fixation of somatic mutations over time, suggesting that they regularly lead to cellular death, partly contributing to maintain a normal lymphocyte count during the prolonged premalignant stage. This equilibrium was finally broken after a period of 18.5 to 60 months of clinical latency, when a dramatic decrease in the genetic instability of premalignant cells coincided with a rapid increase in lymphocyte count and lymphoma onset. [less ▲]

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See detailTransgenic engineering of male-specific muscular hypertrophy.
Pirottin, Dimitri ULiege; Grobet, Luc ULiege; Adamantidis, Antoine ULiege et al

in Proceedings of the National Academy of Sciences of the United States of America (2005), 102(18), 6413-8

Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency ... [more ▼]

Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows. [less ▲]

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See detailL'observation en psychosomatique
Gauthier, Jean-Marie ULiege

in Médecine et psychosomatique (2005)

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See detailA Vectorial Regularization of the Keplerian Motion
Condurache, D.; Martinusi, Vladimir ULiege

in Bulletin of the Polytechnic Institute of Jasi. Section Mathematics, Theoretical Mechanics, Physics = Buletinul Institutului Politehnic din Iaşi. Secţia Matematica, Mecanica Teoretica, Fizica (2005), LI (LIV)

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See detailStudying And Modelling The Combined Effect Of Temperature And Water Activity On The Growth Rate Of P. Expansum
Lahlali, Rachid; Serrhini, Mn.; Jijakli, Mohamed ULiege

in International Journal of Food Microbiology (2005), 103(3), 315-322

The effect of solutes, water activity (aw, 0.890–0.980) and temperature (5–25 8C) on the mycelial growth rate of Penicillium expansum was evaluated. The growth rate dropped as the temperature and aw of ... [more ▼]

The effect of solutes, water activity (aw, 0.890–0.980) and temperature (5–25 8C) on the mycelial growth rate of Penicillium expansum was evaluated. The growth rate dropped as the temperature and aw of the medium decreased. NaCl was the solute causing the greatest growth rate reduction, followed by glucose, glycerol and sorbitol. Statistical analysis of the results showed a significant effect of solute, aw, temperature and combinations of two or three of these factors ( P b0.0001). Whatever the solutes and aw values, the initiation of colony growth required an additional day at 15 8C and 5 8C as compared to initiation at 25 8C. Growth models based on the results obtained with sorbitol and glycerol differed only slightly, with R2 values of 97.00% and 97.95%, respectively. The response surfaces of both quadratic polynomial models showed that P. expansum should be able to grow at low aw (0.890) and that growth at 25 8C should be fastest at aw values ranging from 0.960 to 0.980. Both models presented a good fit between predicted and observed values. [less ▲]

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See detailMaladies infectieuses et micro-organismes : de la préhistoire aux postulats de Koch - grande et petite histoire
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2005), 149C(Special issue), 3-4

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See detailThe Aurignacian in Eastern Europe
Noiret, Pierre ULiege

in Anatolia (2005), 29

In Eastern Europe, a few sites have yielded industries attributed to the Early Aurignacian between 33,000 and 29.000 BP, characterized by bladelet production from bladelet cores and/or from carinated core ... [more ▼]

In Eastern Europe, a few sites have yielded industries attributed to the Early Aurignacian between 33,000 and 29.000 BP, characterized by bladelet production from bladelet cores and/or from carinated core-tools. These industries have affinities with other local industries south of the expansion zone of this Early Aurignacian, but problems with relative and absolute chronologies currently prevented a satisfactory "historical" interpretation of the Aurignacian phenomenon. [less ▲]

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See detailD’immatériels lendemains : la porcelaine contemporaine au Musée royal de Mariemont,
Bawin, Julie ULiege

in Art Même : Chronique des Arts Plastiques de la Communauté française de Belgique (2005)

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See detailNitric oxide "at heart": emerging paradigms after a decade.
Pelat, M.; MASSION, Paul ULiege; Balligand, J. L.

in Archives des Maladies du Coeur et des Vaisseaux (2005), 98(3), 242-8

Despite the apparent redundancy of NOS isoforms in the myocardium, subcellular compartmentation dictates specific NO signaling from each isoform to colocalized effectors in response to physical (e.g ... [more ▼]

Despite the apparent redundancy of NOS isoforms in the myocardium, subcellular compartmentation dictates specific NO signaling from each isoform to colocalized effectors in response to physical (e.g. stretch) or receptor-mediated stimuli. Genetic deletion or overexpression experiments helped to characterize each isoform's respective role in the normal or diseased heart. eNOS and nNOS both contribute to sustain normal EC coupling and contribute to the early and late phases of the Frank-Starling mechanism of the heart. They also negatively modulate the beta1-/beta2-adrenergic increase in inotropy and chronotropy, and reinforce the (pre- and post-synaptic) vagal control of cardiac contraction, thereby protecting the heart against excessive stimulation by catecholamines. In the ischemic and failing myocardium, iNOS expression is induced and further contributes to attenuate the inotropic effect of catecholamines, as does eNOS coupled to overexpressed beta3-adrenoceptors. nNOS expression also increases in the aging and ischemic heart, but its role (compensatory or deleterious) remains to be defined. Many drugs currently used for the treatment of ischemic or failing cardiac diseases also activate and/or upregulate eNOS in the myocardium, which supports its proposed protective role, e.g. as "endogenous beta-blocker". Future pharmacologic modulation of the cardiac NOS will have to take into account their specific modulation of the various aspects of cardiac function, if one hopes to deliver more targeted and efficient therapy than currently achieved with exogenous NO donors. [less ▲]

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See detailHow Mannheimia haemolytica defeats host defence through a kiss of death mechanism
Zecchinon, Laurent ULiege; Fett, Thomas ULiege; Desmecht, Daniel ULiege

in Veterinary Research (2005), 36(Mar-Apr), 133-156

Mannheimia haemolytica induced pneumonias are only observed in goats, sheep and cattle. The bacterium produces several virulence factors,whose principal ones are lipopolysaccharide and leukotoxin. The ... [more ▼]

Mannheimia haemolytica induced pneumonias are only observed in goats, sheep and cattle. The bacterium produces several virulence factors,whose principal ones are lipopolysaccharide and leukotoxin. The latter is cytotoxic only for ruminant leukocytes, a phenomenon that is correlated with its ability to bind and interact with the ruminant beta2-integrin Lymphocyte Function-associated Antigen 1. This paper globally reviews all the information available on host-pathogen interactions underlying respiratory mannheimiosis (formerly pasteurellosis), from the stable and the Petri dish to the biochemical cascade of events triggered by the leukotoxin inside ruminant leukocytes. One conclusion can be made: the most widespread cattle respiratory disease with the most important impact on beef production worldwide, is probably due to a tiny ruminant-specific focal variation in the CD18- and/or CD11a-expressing genes. [less ▲]

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See detailFaut-il un ou plusieurs indicateurs d'exclusion sociale ?
Lefebvre, Mathieu ULiege

in Revue Belge de Sécurité Sociale (2005)

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See detailNecrotoxigenic Escherichia coli : study of the roles of CNF2 and CDT-III toxins in an experimental model of infection in calves
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2005), 149(Sp. Iss. SI), 46-48

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See detailDu rififi dans le monde de l'onychomycose.
Pierard, Gérald ULiege

in Revue Médicale de Liège (2005), 60(4), 242-6

Recently, onychomycoses raised some interest from groups whose business is communication to the public. The combination of commercial interest, dogmatism and disinformation appears to have found there a ... [more ▼]

Recently, onychomycoses raised some interest from groups whose business is communication to the public. The combination of commercial interest, dogmatism and disinformation appears to have found there a potentially damaging field of action. This review is an attempt to shed some light on this topic using objective and qualified medical information. [less ▲]

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See detailL’enseignement de l’éducation physique en Communauté française de Belgique
Cloes, Marc ULiege

in Revue de la Fédération des Educateurs et Educatrices Physiques Enseignants du Québec (2005), 17(2), 16-18

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See detailA physiological overview of the genetics of flowering time control.
Bernier, Georges ULiege; Périlleux, Claire ULiege

in Plant Biotechnology Journal (2005), 3(1), 3-16

Physiological studies on flowering time control have shown that plants integrate several environmental signals. Predictable factors, such as day length and vernalization, are regarded as 'primary', but ... [more ▼]

Physiological studies on flowering time control have shown that plants integrate several environmental signals. Predictable factors, such as day length and vernalization, are regarded as 'primary', but clearly interfere with, or can even be substituted by, less predictable factors. All plant parts participate in the sensing of these interacting factors. In the case of floral induction by photoperiod, long-distance signalling is known to occur between the leaves and the shoot apical meristem (SAM) via the phloem. In the long-day plant, Sinapis alba, this long-distance signalling has also been shown to involve the root system and to include sucrose, nitrate, glutamine and cytokinins, but not gibberellins. In Arabidopsis thaliana, a number of genetic pathways controlling flowering time have been identified. Models now extend beyond 'primary' controlling factors and show an ever-increasing number of cross-talks between pathways triggered or influenced by various environmental factors and hormones (mainly gibberellins). Most of the genes involved are preferentially expressed in meristems (the SAM and the root tip), but, surprisingly, only a few are expressed preferentially or exclusively in leaves. However, long-distance signalling from leaves to SAM has been shown to occur in Arabidopsis during the induction of flowering by long days. In this review, we propose a model integrating physiological data and genes activated by the photoperiodic pathway controlling flowering time in early-flowering accessions of Arabidopsis. This model involves metabolites, hormones and gene products interacting as long- or short-distance signalling molecules. [less ▲]

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See detailVariabilité spatio-temporelle de l’albédo. Analyse menée à la résolution métrique
Van Durme, G.; Erpicum, Michel ULiege

in Bulletin de la Société Géographique de Liège (2005), 46

Albedo is a climatic factor that has been barely studied and thus is badly understood. However, it has a certain influence on our climate. This influence is especially visible in case of land use changes ... [more ▼]

Albedo is a climatic factor that has been barely studied and thus is badly understood. However, it has a certain influence on our climate. This influence is especially visible in case of land use changes, such as deforestation. The aim of the study presented in this paper is to increase the current knowledge on albedo and the factors that influence it. To achieve this, a field survey was conducted. Not all factors could be studied during the field campaign; among those that were effectively observed, the most important ones – those that were responsible for the biggest changes in albedo – were the development of vegetation, the presence of snow and the daily variation of the height of the sun. [less ▲]

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See detailUse of a homologous radioimmunoassay (RIA) to evaluate the effect of maternal and foetal parameters on pregnancy-associated glycoprotein (PAG) concentrations in sheep
Vandaele, Leen; Verberckmoes, S.; El Amiri, Bouchra et al

in Theriogenology (2005), 63(7), 1914-1924

Early pregnancy detection and prediction of the number of lambs would be profitable for sheep breeders because it enables them to adjust nourishment of pregnant ewes according to the individual needs in ... [more ▼]

Early pregnancy detection and prediction of the number of lambs would be profitable for sheep breeders because it enables them to adjust nourishment of pregnant ewes according to the individual needs in order to prevent health problems around parturition. The concentration of ovPAG has previously been reported to be related with maternal parameters (farm, breed and age) as well as foetal parameters (number of lambs, their sex and birth weight), but contradictory results were obtained in different small-scale studies. This large-scale study evaluates the effect of these parameters on the ovPAG concentration, determined by a homologous radioimmunoassay (RIA), and it further investigates the possibility to predict the number of lambs by means of homologous ovPAG determination. Eighty-three and ninety-five ewes of the Suffolk and Texel breed, respectively, housed on four different farms (experiment 1) and 68 ewes of the Suffolk breed, housed on two different farms During the last 6 weeks of pregnancy determination of 3-OH butyrate can be used to determine a necessary nutrition correction [4]. In conclusion, the present study has shown an effect of different parameters such as farm, breed of the ewes, and number and birth weight of the lambs on ovPAG concentrations at all time points. Prediction of litter size based on ovPAG concentrations at the individual ewe level was not useful due to small sensitivity and/or specificity, notwithstanding significantly increased odds of multiple lambs. Furthermore, age of the ewes and sex did not have an impact oil ovPAG levels. [less ▲]

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See detailOccurrence of the genotype of the receptor gene for ryanodine (Ryr1) associated with sensitivity to stress in 5 Belgian porcine production systems
China, Bernard; Leroy, Bernadette ULiege; Dams, Lorène ULiege et al

in Annales de Médecine Vétérinaire (2005), 149(3), 161-165

Porcine stress syndrome is related to a point mutation in Ryr1 gene encoding the ryanodin receptor. This syndrome involves mortality after stress conditions or poor quality meat. Five hundred and five ... [more ▼]

Porcine stress syndrome is related to a point mutation in Ryr1 gene encoding the ryanodin receptor. This syndrome involves mortality after stress conditions or poor quality meat. Five hundred and five individuals among 5 Belgian production systems were genotyped. This genotyping was performed by polymerase chain reaction-restriction fragment length polymophism (PCR-RFLP) or real time PCR. The results indicated that 22,4 % of the pigs were stress sensitive (TT genotype) and 77,6 % stress resistant (63,4 % CT heterozygotes and 14,2 % CC genotype). Statistical analysis allowed to split the production systems into two groups: the production system 1 and 2 presenting a high level of TT individuals (44 % and 52 % respectively) although production systems 3, 4 and 5 presented a high level of heterozygotes individuals (74 %, 92 % and 78 % respectively). At the technical level, real time PCR appeared to be a faster and an easier technique than PCR-RFLP. [less ▲]

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See detailCaractérisation et maîtrise des paramètres de la reproduction et de la croissance des ovins Djallonké (Ovis amon aries)
Gbangboche, A. B.; Hornick, Jean-Luc ULiege; Adamou-N'Diaye, M. et al

in Annales de Médecine Vétérinaire (2005), 149(3), 148-160

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See detailAutomates et systèmes de numération
Rigo, Michel ULiege

in Bulletin de la Société Royale des Sciences de Liège (2005), 73

Ce survol introductif est basé sur une mini-conférence réalisée à la Société Royale des Sciences de Liège en avril 2004 et sur un exposé réalisé à l’IUFM de Reims en juin 2003 (Integrating Technologies ... [more ▼]

Ce survol introductif est basé sur une mini-conférence réalisée à la Société Royale des Sciences de Liège en avril 2004 et sur un exposé réalisé à l’IUFM de Reims en juin 2003 (Integrating Technologies into Mathematics Education). Nous y présentons divers systèmes de numération du point de vue de la théorie des langages formels. On s’attache dès lors à mettre en lumière les liens éventuels entre propriétés arithmétiques des nombres et propriétés syntaxiques de leurs représentations. La première partie de ce texte introduit en particulier la notion d’automate et quelques unes de ses applications. [less ▲]

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See detailInfluence of oxygen tension on nitric oxide and prostaglandin E2 synthesis by bovine chondrocytes.
Mathy, Marianne ULiege; Burton, Sandrine; Deby, Ginette ULiege et al

in Osteoarthritis and Cartilage (2005), 13(1), 74-9

OBJECTIVES: To determine the in vitro effects of oxygen tension on interleukin (IL)-1beta induced nitric oxide (*NO) and prostaglandin E(2) (PGE(2)) production by bovine chondrocytes. DESIGN ... [more ▼]

OBJECTIVES: To determine the in vitro effects of oxygen tension on interleukin (IL)-1beta induced nitric oxide (*NO) and prostaglandin E(2) (PGE(2)) production by bovine chondrocytes. DESIGN: Enzymatically isolated bovine chondrocytes were cultured for different periods in suspension in 21 (atmospheric), 5 or 1% (low) oxygen tension and in the absence or in the presence of increased amounts (0.01 to 1nM) of IL-1beta. Nitrite and nitrate concentrations in the culture supernatants were determined by a spectrophotometric method based upon the Griess reaction. PGE(2) production was quantified by a specific radioimmunoassay (RIA). Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNA steady state levels were also quantified by real-time polymerase chain reaction (PCR). RESULTS: In the absence of IL-1beta, ()NO production remained stable whatever the oxygen tension used. IL-1beta dose-dependently increased *NO production in both atmospheric and low oxygen conditions but the effect was more pronounced in low (1 and 5%) than in atmospheric (21%) oxygen tension (P<0.001). Under low and atmospheric oxygen tension, iNOS gene expression was increased by IL-1beta, but to a lesser extent in 21% than in 1 or 5% oxygen (P<0.01). In the basal condition, bovine chondrocytes spontaneously produced PGE(2) whatever the oxygen tension used. At 21% oxygen, IL-1beta dose-dependently increased PGE(2) production while no significant effect was observed at 1 or 5% oxygen. COX-2 gene expression was significantly upregulated by IL-1beta in both low and atmospheric oxygen tension. No significant difference between oxygen tension conditions was observed. CONCLUSIONS: This study demonstrates that a hypoxic environment fully blocks COX-2 activity but favours iNOS gene expression in chondrocytes culture. These findings indicate that O(2) tension modulates cellular behaviour in culture and supports the concept of chondrocyte culture in low oxygen tension to reproduce in vitro the life conditions of chondrocytes. [less ▲]

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See detailHistone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility
Waltregny, David ULiege; Glenisson, Wendy; Tran, Syv Li et al

in FASEB Journal (2005), 19(8), 966-968

Although originally characterized as nuclear enzymes controlling the stability of nucleosomes, histone deacetylases (HDACs) may also exert their activity within the cytosol. Recently, we have demonstrated ... [more ▼]

Although originally characterized as nuclear enzymes controlling the stability of nucleosomes, histone deacetylases (HDACs) may also exert their activity within the cytosol. Recently, we have demonstrated that HDAC8, a class I HDAC, is a novel, prominently cytosolic marker of smooth muscle differentiation. As HDAC8 displays a striking stress fiber-like pattern of distribution and is coexpressed in vivo with smooth muscle alpha-actin (alpha-SMA) and smooth muscle myosin heavy chain, we have explored the possible participation of this HDAC in smooth muscle cytoskeleton regulation. Cell fractionation assays performed with primary human smooth muscle cells (HSMCs) showed that HDAC8, in contrast to HDAC1 and HDAC3, was enriched in cytoskeleton-bound protein fractions and insoluble cell pellets, suggesting an association of HDAC8 with the cystoskeleton. Coimmunoprecipitation experiments using HSMCs, NIH-3T3 cells, and human prostate tissue lysates further demonstrated that HDAC8 associates with alpha-SMA but not with beta-actin. HDAC8 silencing through RNA interference strongly reduced the capacity of HSMCs to contract collagen lattices. Mock transfections had no effect on HSMC contractily, and transfections with small interfering RNAs (siRNAs) specific for HDAC6, a cytosolic HDAC that functions as an alpha-tubulin deacetylase, resulted in a weak contraction inhibition. Although mock- and HDAC6 siRNA-transfected HSMCs showed no noticeable morphological changes, HDAC8 siRNA-transfected HSMCs displayed a size reduction with diminished cell spreading after replating. Altogether, our findings indicate that HDAC8 associates with the smooth muscle actin cytoskeleton and may regulate the contractile capacity of smooth muscle cells. [less ▲]

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See detailFinit element modelling of an asynchronous motor with one broken rotor bar, comparison with the data recorded on a prototype and material aspects
Guérard, Suzanne ULiege; Gyselinck, Johan; Lecomte-Beckers, Jacqueline ULiege

in Bulletin Scientifique de l'AIM (Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore) (2005), 1

This work studies the problem of broken rotor bars in cage induction motors. To this aim, an induction machine from WEG Motors was modelled by means of the finite element method. The motor modelled is a ... [more ▼]

This work studies the problem of broken rotor bars in cage induction motors. To this aim, an induction machine from WEG Motors was modelled by means of the finite element method. The motor modelled is a 18.5 kW four-pole induction motor with a straight rotor cage. The field distribution and stator phase currents were computed for a motor without broken rotor bars and for a motor with one broken rotor bar. The computed stator phase currents were compared to the ones recorded on motors respectively no broken rotor bar and with one broken rotor bar. The FE model and an equivalent scheme of the motor permitted to show that the resistance of the rotor cage was higher than expected, considering only the temperature effect on the conductivity of the rotor bars. A metallurgic analysis of the aluminium alloy of two rotor bars revealed the presence of a very high density of silicon and silicon oxide inclusions, as well as the presence of shrinkages and cracks, which have a negative impact on both conductivity and mechanical strength. A corrected value of the rotor bar conductivity was used in the finite element model and led to a good agreement with the experimental results. The field perturbation associated with a broken rotor bar produces a concentration of flux near the bar ahead of the broken one, considering the counterclockwise direction of rotation of the rotor. This flux concentration results in higher current values and hence in higher stresses in the bar ahead of the broken one. [less ▲]

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See detailPensieri sulla critica della traduzione e sulla sua ricezione
Curreri, Luciano ULiege

in Palazzo Sanvitale (2005), 15/16

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See detailA patient who survived total colonic ulcerative colitis surinfected by cytomegalovirus complicated by toxic megacolon and disseminated intravascular coagulation
Laurent, S.; Reenaers, Catherine ULiege; Detroz, Bernard ULiege et al

in Acta Gastro-Enterologica Belgica (2005), 68(2, Apr-Jun), 276-279

The authors report the case of a patient aged 60-year-old who survived ulcerative colitis complicated by toxic megacolon and disseminated intravascular coagulation. This patient was not known for this ... [more ▼]

The authors report the case of a patient aged 60-year-old who survived ulcerative colitis complicated by toxic megacolon and disseminated intravascular coagulation. This patient was not known for this ulcerative colitis and was first hospitalised for a suspicion of diverticulitis. The admission symptoms were fever, abdominal pain and bloody diarrhoea. The evolution was defavorable under antibiotics and sulfasalazine. The patient was readmitted 5 days after he left hospital, and the diagnosis of UC was based on colon biopsy made during the first hospitalisation. A treatment with methylprednisolone was started and the patient worsened day by day with apparition of toxic megacolon and disseminated intravascular coagulation. Subtotal colectomy was performed for degradation of general status and coagulation factors. Pathological findings confirmed ulcerative colitis with toxic megacolon. Cytomegalovirus inclusions were demonstrated on the colonic specimen and confirmed by PCR. In this report the authors discuss the etiology of toxic megacolon and disseminated intravascular coagulation in ulcerative colitis surinfected by cytomegalovirus. Mortality of these pathologies is high necessitating rapid diagnosis of cytomegalovirus infection by sigmoid biopsy. Management requires immunosupression interruption and ganciclovir therapy, or surgery in unsuccessful medical treatment. [less ▲]

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See detailDrug-induced toxic epidermal necrolysis and pancytopenia: a puzzling association.
Paquet, Philippe ULiege; Jacob, Eric; Pirson, J. et al

in International Journal of Molecular Medicine (2005), 16(1), 29-33

The molecular mechanisms involved in the pathogenesis of toxic epidermal necrolysis (TEN) remain not fully understood. We report a unique case of antibiotic-induced TEN developed in a patient who also ... [more ▼]

The molecular mechanisms involved in the pathogenesis of toxic epidermal necrolysis (TEN) remain not fully understood. We report a unique case of antibiotic-induced TEN developed in a patient who also suffered from prolonged severe methotrexate-induced pancytopenia. The objective of the study was to explore the nature of the cutaneous inflammatory infiltrate and the density in dermal dendrocytes (DD). Immunohistochemistry was used to identify activated T lymphocytes (CD45R0), monocyte-macrophages (Mac 387, CD68), DD (Factor XIIIa), and Langerhans cells (CD1a). The proliferation marker (Ki67) and the antibody to Fas receptor (CD95R) were also used to assess the distribution of the germinative pool of keratinocytes and the FAS-related apoptotic process, respectively. Numerous Factor XIIIa+ DD were present in the papillary dermis with only sparce perivascular CD45RO+ T lymphocytes and scattered CD68+ or Mac 387+ macrophages. Double immunostainings revealed that a minority of Factor XIIIa+ DD co-expressed the CD68 glycoprotein (a marker of phagocytic activity). No cells co-expressed factor XIIIa and Mac 387 immunoreactivities. CD45RO+ T lymphocytes, CD68+ and Mac 387+ macrophages were absent in the epidermis. The expression of CD95R was present although restricted to the basal keratinocytes, while the L1-protein (Mac 387+) was diffusely present in the epidermis. Langerhans cells (CD1a+) were sparce, but normal in distribution. The presence of a great number of Factor XIIIa+ DD without any possible recent recruitment from bone marrow suggests that these cells differentiated from resident cells of the skin. Indeed, there was no co-expression of Factor XIIIa and L1-protein, thus showing the absence of recruitment from monocytes. The simultaneous over-expression of Factor XIIIa and CD68 in some DD indicates some phagocytic activity. In view of the absence of inflammatory cells in the epidermis, keratinocytes appeared responsible for their own destruction through CD95-mediated and/or calcium-dependent apoptotic pathways. This finding entails that TEN treatments should target the keratinocyte metabolism rather than the circulating inflammatory cells which presumably play a limited role, if any, in the epidermal destructive process. [less ▲]

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See detailVers une définition opérationnelle de la notion de compétence
Chenu, Florent ULiege

in Education Permanente (2005), 162(1), 201-208

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See detailEditorial Report 2003-2005 and acknowledgements of reviewers 2004: 13th OGM meeting, Bonn, 1st October 2005
Denoël, Mathieu ULiege

in Amphibia-Reptilia (2005), 26(4), 587-588

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See detailMurine bone marrow stromal cells sustain in vivo the survival of hematopoietic stem cells and the granulopoietic differentiation of more mature progenitors.
Hubin, Frederique; Humblet, Chantal ULiege; Belaid, Zakia ULiege et al

in Stem Cells (2005), 23(10), 1626-33

The study of the human hematopoietic system would be facilitated by availability of a relevant animal model. Because the medullar microenvironment is made of different types of cells, interactions between ... [more ▼]

The study of the human hematopoietic system would be facilitated by availability of a relevant animal model. Because the medullar microenvironment is made of different types of cells, interactions between hematopoietic cells and stromal cells are difficult to analyze in detail. As an approach for establishing an in vivo model to dissect these interactions, we grafted murine bone marrow fibroblastic cells (MS-5 cell line) with hematopoietic cells into the kidney capsule of syngenic mice. To identify the origin of cells present in the graft, we used green fluorescent protein-stable transfected MS-5 cells for the transplantation. To analyze the evolution of stromal cells and identify hematopoietic cells able to develop in these conditions, we performed morphology, histochemistry, and immunohistology on tissue sections at different times after transplantation. When injected alone, MS-5 cells differentiate into adipocytes. When injected with a bone marrow suspension or with isolated CD45+ cells (leukocytes), the stromal cells keep their fibroblastic morphology and their alkaline phosphatase expression and sustain granulopoiesis. When injected with hematopoietic stem cells called c-kit+ Sca-1+ Lin- suspension, clusters of hematopoietic cells are also observed: They do not present any granulopoietic activity and do not belong to B or T population nor to erythroid lineage. They are quiescent, induce bone marrow recovery and survival of lethally irradiated recipients, are able to form macroscopic colonies in the spleen, and are able to form very few colonies in vitro, suggesting that they are hematopoietic stem cells. In conclusion, our results show that reticular fibroblastic stromal cells MS-5 sustain the survival of stem cells and are not able to induce their differentiation. However, they can control differentiation, proliferation, and/or survival of hematopoietic cells engaged in myeloid lineage. [less ▲]

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See detailTransobturator vaginal tape inside out for the surgical treatment of female stress urinary incontinence: anatomical considerations.
Bonnet, Pierre ULiege; Waltregny, David ULiege; Reul, Olivier ULiege et al

in Journal of Urology (The) (2005), 173(4), 1223-8

PURPOSE: We have recently described a novel surgical technique for female stress urinary incontinence, that is the transobturator vaginal tape inside out, which uses specific instruments for the passage ... [more ▼]

PURPOSE: We have recently described a novel surgical technique for female stress urinary incontinence, that is the transobturator vaginal tape inside out, which uses specific instruments for the passage of a synthetic tape from beneath the urethra toward the thigh folds. Herein we report the results of cadaver dissection performed to determine the anatomical trajectory of the tape and its relationships with neighboring neurovascular structures and organs. MATERIALS AND METHODS: Insertion of the transobturator vaginal tape inside out tape was performed by different surgeons in 12 freshly frozen female cadavers according to the standard procedure. The thigh, obturator, perineal and pelvic regions were dissected and tape trajectory was recorded. An additional cadaver was dissected without prior tape placement. RESULTS: The tape was inserted according to a certain consistent path, that is penetration from the suburethral space into a strictly perineal region limited medial and cranial by the levator ani muscle, caudal by the perineal membrane and lateral by the obturator internus muscle. This region corresponded to the most anterior recess of the ischiorectal fossa. The tape then perforated the obturator membrane and muscles, and exited through the skin after traversing adductor muscles and subcutaneous tissue. The tape was coursed away from 1) the dorsal nerve to the clitoris located more superficially below the perineal membrane, 2) the obturator nerve and vessels, and 3) the saphenous and femoral vessels. CONCLUSIONS: These findings strongly suggest that our transobturator technique is highly accurate, reproducible and safe, and it does not require perioperative cystoscopy. [less ▲]

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See detailNormes et distances en statistique
Bair, Jacques ULiege; Henry, Valérie ULiege

in Tangente Sup (2005), 26

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See detailLe problème de la solidarité : De Durkheim à Sartre
Cormann, Grégory ULiege

in Etudes Sartriennes (2005), 10

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See detailVérités de science, vérités de foi : lectures libertines d’une distinction polysémique
Torero-Ibad, Alexandra ULiege

in Libertinage et philosophie au XVIIe siècle (2005), 9

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See detailPityriasis versicolor anhidrotique.
Uhoda, Emmanuelle ULiege; Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Dermatologie Actualité (2005), 89

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See detailHéliodermie, héliophiles et héliophobes.
Quatresooz, Pascale ULiege; Uhoda, I.; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2005), 60 Suppl 1

The cumulative effect of lifelong sun exposures induces skin alterations which are coined helioderma. The manifestations of helioderma vary according to the body site. This is particularly the case for ... [more ▼]

The cumulative effect of lifelong sun exposures induces skin alterations which are coined helioderma. The manifestations of helioderma vary according to the body site. This is particularly the case for the prominent differences in the expression of solar elastosis. This condition is commonly more severe on the face and nape of the neck than on the forearms and back of the hands. The age, phototype and behaviour regarding sun exposure are cofactors responsible for the severity of solar elastosis. [less ▲]

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See detailModélisation de la distribution spatiale des précipitations en Sicile.
Cornet, Yves ULiege; Fitschy, C.; Gobbato, O. et al

in Bulletin de la Société Géographique de Liège (2005), 46

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See detailLa peau dite sèche du patient diabétique.
Uhoda, Emmanuelle ULiege; Debatisse, B.; Paquet, Philippe ULiege et al

in Revue Médicale de Liège (2005), 60(5-6), 560-3

Rough skin or xerosis, known by the laity as dry skin, results from a defect in the stratum corneum desquamation which normally remains imperceptible. This condition is negatively influenced by winter ... [more ▼]

Rough skin or xerosis, known by the laity as dry skin, results from a defect in the stratum corneum desquamation which normally remains imperceptible. This condition is negatively influenced by winter climatic conditions. Atopic dermatitis and trophic changes related to post-menopause, ageing, diabetes mellitus, as well as other endrocrine and metabolic disturbances are also involved in this process. Xerosis can be improved at various degrees by emollients, humectants, hydrating agents and squamolytic agents. [less ▲]

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See detailFormation and structural characteristics of Pd-Ag/SiO2 and Pd-Cu/SiO2 catalysts synthesized by cogelation
Lambert, Stéphanie ULiege; Gommes, Cédric ULiege; Alié, Christelle ULiege et al

in Journal of Non-Crystalline Solids (2005), 351(52-54), 3839-3853

Pd-Ag/SiO2 and Pd-Cu/SiO2 xerogel catalysts have been synthesized by cogelation of tetraethoxysilane (TEOS) and chelates of either Pd and Ag or Pd and Cu with 3-(2-aminoethylamino)propyltrimethoxysilane ... [more ▼]

Pd-Ag/SiO2 and Pd-Cu/SiO2 xerogel catalysts have been synthesized by cogelation of tetraethoxysilane (TEOS) and chelates of either Pd and Ag or Pd and Cu with 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS). After an extensive study of the influences of synthesis operating variables over structural characteristics of gels, highly dispersed bimetallic Pd-Ag/SiO2 and Pd-Cu/SiO2 xerogel catalysts were obtained. These samples are then composed of completely accessible Pd-Ag and Pd-Cu alloy crystallites with sizes of 2-3.5 nm located inside silica particles exhibiting a monodisperse microporous distribution. It appears also that the metal complex acts as a nucleation agent in the formation of silica particles. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailL'accueil de la décision-cadre relative au mandat d'arrêt européen en Belgique
Flore, Daniel ULiege

in Droit de l'Union européenne-Colloques (2005)

L'élaboration d'un droit pénal européen est un processus complexe constitué d'étapes successives. On aborde ici la question de l'accueil de la décision-cadre relative au mandat d'arrêt européen en ... [more ▼]

L'élaboration d'un droit pénal européen est un processus complexe constitué d'étapes successives. On aborde ici la question de l'accueil de la décision-cadre relative au mandat d'arrêt européen en Belgique. [less ▲]

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See detailRestauration ou falsification ? Le "Saint Jérôme pénitent" attribué à Albert Bouts conservé au Musée de l’Art wallon à Liège
Falque, Ingrid ULiege

in Leodium (2005), 118

Cet article livre une analyse approfondie d’un tableau désormais conservé au musée Grand Curtius à Liège. Jadis attribuée à Albert Bouts, cette œuvre doit aujourd’hui être attribuée à un anonyme flamand ... [more ▼]

Cet article livre une analyse approfondie d’un tableau désormais conservé au musée Grand Curtius à Liège. Jadis attribuée à Albert Bouts, cette œuvre doit aujourd’hui être attribuée à un anonyme flamand actif vers 1530. En outre, les analyses de laboratoire que j’ai effectuées sur le tableau ont montré qu’il a subi une importante campagne de falsification dans le courant du XIXe ou du XXe siècle. [less ▲]

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See detailEscherichia coli fusion carrier proteins act as solubilizing agents for recombinant uncoupling protein 1 through interactions with GroEL.
Douette, P.; Navet, R.; Gerkens, P. et al

in Biochemical and Biophysical Research Communications (2005), 333

Fusing recombinant proteins to highly soluble partners is frequently used to prevent aggregation of recombinant proteins in Escherichia coli. Moreover, co-overexpression of prokaryotic chaperones can ... [more ▼]

Fusing recombinant proteins to highly soluble partners is frequently used to prevent aggregation of recombinant proteins in Escherichia coli. Moreover, co-overexpression of prokaryotic chaperones can increase the amount of properly folded recombinant proteins. To understand the solubility enhancement of fusion proteins, we designed two recombinant proteins composed of uncoupling protein 1 (UCP1), a mitochondrial membrane protein, in fusion with MBP or NusA. We were able to express soluble forms of MBP-UCP1 and NusA-UCP1 despite the high hydrophobicity of UCP1. Furthermore, the yield of soluble fusion proteins depended on co-overexpression of GroEL that catalyzes folding of polypeptides. MBP-UCP1 was expressed in the form of a non-covalent complex with GroEL. MBP-UCP1/GroEL was purified and characterized by dynamic light scattering, gel filtration, and electron microscopy. Our findings suggest that MBP and NusA act as solubilizing agents by forcing the recombinant protein to pass through the bacterial chaperone pathway in the context of fusion protein. [less ▲]

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See detailDécalage interdisciplinaire dans l'enseignement universitaire en économie
Bair, Jacques ULiege; Henry, Valérie ULiege

in Idées : la revue des sciences économiques et sociales (2005), 141

Nous proposons un modèle élémentaire qui met en évidence l'existence possible d'un décalage épistémologique résultant de la transmission d'un même savoir par deux communautés d'enseignants en ... [more ▼]

Nous proposons un modèle élémentaire qui met en évidence l'existence possible d'un décalage épistémologique résultant de la transmission d'un même savoir par deux communautés d'enseignants en mathématiques et en économie. [less ▲]

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See detailEt si les RAMBAs étaient à l'horizon? Une histoire belge qui rebondit.
Pierard, Gérald ULiege; Vroome, Valérie; Stoppie, P. et al

in Dermatologie Actualité (2005), 90

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See detailLe cas clinique du mois. Le Twiddler's syndrome.
SakalihasanN, Natzi ULiege; Radermacher, V.; Chevolet, C. et al

in Revue Médicale de Liège (2005), 60(7-8), 647-8

The Twiddler's syndrome is characterized by the migration of pacemaker's leads due to rotation of the pulse generator. In our case, ventricular leads coiled in the upper side of the right atrium with ... [more ▼]

The Twiddler's syndrome is characterized by the migration of pacemaker's leads due to rotation of the pulse generator. In our case, ventricular leads coiled in the upper side of the right atrium with stimulation of pectoralis major muscle during left decubitus lateralis position. [less ▲]

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See detailStriae distensae in darker skin types: the influence of melanocyte mechanobiology.
Pierard, Claudine ULiege; Hermanns, Jean-François ULiege; Hermanns-Lê, Trinh ULiege et al

in Journal of Cosmetic Dermatology (2005), 4(3), 174-8

Introduction Striae distensae in White people are commonly described as being reddish at first and turning white in time. This dual perception has been challenged. Indeed, the color difference between ... [more ▼]

Introduction Striae distensae in White people are commonly described as being reddish at first and turning white in time. This dual perception has been challenged. Indeed, the color difference between striae distensae and their surrounding skin varies on a wide range in part depending upon typology. Aim To study striae nigrae that are found only in subjects of darker complexion. Materials and methods In the present study conducted in 44 darker skin adults, dermoscopy was combined to reflectance colorimetry. Results Striae nigrae exhibited hypermelanosis of the epidermal rete ridges crossing transversally the lesions in a laddering pattern. By contrast, striae albae showed only faint melanotic networks. Conclusions As striae distensae are in part under the influence of skin stretching, their colors are likely to be controlled by some mechanobiological process activating or inhibiting melanogenesis in people of darker complexion. No argument involving an inflammatory mechanism is supported by the present observations. [less ▲]

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See detailContribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions.
Cosemans, Judith M E M; Kuijpers, Marijke J E; Lecut, Christelle ULiege et al

in Atherosclerosis (2005), 181(1), 19-27

Collagens (types I and III) are among the strongest thrombus-forming components of the vascular subendothelium. We compared the thrombogenic effects of four collagen-containing advanced atherosclerotic ... [more ▼]

Collagens (types I and III) are among the strongest thrombus-forming components of the vascular subendothelium. We compared the thrombogenic effects of four collagen-containing advanced atherosclerotic lesions with those of purified types I and III collagen fibers. Cell-free homogenates from the human plaques effectively promoted platelet adhesion and aggregate formation under high-shear flow conditions, as well as exposure of procoagulant phosphatidylserine (PS) on platelets. With all plaques, blocking of the glycoprotein VI (GPVI) receptor for collagen abolished aggregation and PS exposure. Blocking of platelet ADP receptors resulted in similar, but less complete inhibitory effects. Type I collagen was more potent than type III collagen in inducing aggregation and PS exposure under flow, via stimulation of GPVI and ADP receptors. Type I collagen also more strongly enhanced thrombin generation with platelets and tissue factor, again via GPVI activation and PS exposure. The plaque material enhanced thrombin generation, partly due to the presence of tissue factor and partly via GPVI and ADP receptors. Together, these results indicate that in advanced plaques collagen type I is a major trigger of thrombus formation and PS exposure, acting via GPVI and ADP release, while tissue factor directly enhances coagulation. [less ▲]

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See detailRéseaux et souvenirs littéraires : le cas d'André Fontainas
Dozo, Björn-Olav ULiege; de Marneffe, Daphné

in Textyles : Revue des Lettres Belges de Langue Française (2005), 26-27

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See detailsox4b is a key player of pancreatic alpha cell differentiation in zebrafish
Mavropoulos, A.; Devos, Nathalie; Biemar, Frédéric et al

in Developmental Biology (2005), 285(1), 211-23

Pancreas development relies on a network of transcription factors belonging mainly to the Homeodomain and basic Helix-Loop-Helix families. We show in this study that, in zebrafish, sox4, a member of the ... [more ▼]

Pancreas development relies on a network of transcription factors belonging mainly to the Homeodomain and basic Helix-Loop-Helix families. We show in this study that, in zebrafish, sox4, a member of the SRY-like HMG-box (SOX) family, is required for proper endocrine cell differentiation. We found that two genes orthologous to mammalian Sox4 are present in zebrafish and that only one of them, sox4b, is strongly expressed in the pancreatic anlage. Transcripts of sox4b were detected in mid-trunk endoderm from the 5-somite stage, well before the onset of expression of the early pancreatic gene pdx-1. Furthermore, by fluorescent double in situ hybridization, we found that expression of sox4b is mostly restricted to precursors of the endocrine compartment. This expression is not maintained in differentiated cells although transient expression can be detected in alpha cells and some beta cells. That sox4b-expressing cells belong to the endocrine lineage is further illustrated by their absence from the pancreata of slow-muscle-omitted mutant embryos, which specifically lack all early endocrine markers while retaining expression of exocrine markers. The involvement of sox4b in cell differentiation is suggested firstly by its up-regulation in mind bomb mutant embryos displaying accelerated pancreatic cell differentiation. In addition, sox4b knock-down leads to a drastic reduction in glucagon expression, while other pancreatic markers including insulin, somatostatin, and trypsin are not significantly affected. This disruption of alpha cell differentiation is due to down-regulation of the homeobox arx gene specifically in the pancreas. Taken together, these data demonstrate that, in zebrafish, sox4b is expressed transiently during endocrine cell differentiation and plays a crucial role in the generation of alpha endocrine cells. [less ▲]

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See detailImprovement of lupin seed valorisation by the pig with the addition of alpha-galactosidase in the feed and the choice of a suited variety.
Froidmont, E.; Wathelet, Bernard ULiege; Beckers, Yves ULiege et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2005), 9(4), 225-235

Three experiments were conducted to assess whether an a-galactosidase supplement improved the utilisation of lupin seeds by growing and finishing pigs and to determine the best lupin variety in presence ... [more ▼]

Three experiments were conducted to assess whether an a-galactosidase supplement improved the utilisation of lupin seeds by growing and finishing pigs and to determine the best lupin variety in presence of a-galactosidase. In experiment 1, three iso-nitrogen (iso-N) and iso-net energy (iso-NE) diets containing 15% of soybean meal (SBM diet) or 20% of lupin seeds (Lupinus albus var. Arès), with or without an a-galactosidase supplement (‘lupin’ and ‘lupin + a-gal’ diets, respectively), were ingested by 12 pigs fitted with a caecal canula, following a completely randomized experimental design. The ileal digestibility of a-galactosides tended to increase with the lupin + a-gal diet. Nitrogen retention of pigs eating the SBM diet was similar to that of those fed with the lupin + a-gal diet and higher than that observed for pigs given the lupin diet. The results suggested that a-galactosides are the main anti-nutritional factors in lupin seeds for pigs. The same diets were investigated in a production trial (experiment 2) involving 48 pigs with a live weight of between 30 and 105 kg. The fattening period was similar for the SBM and lupin + a-gal diets (107 d) and longer for the lupin diet (123 d). With the lupin diet there was a lower average daily gain (ADG, -16%) and a higher food conversion ratio (FCR, + 8%) than with the two other diets. The backfat of pigs fed with lupin-based diets contained fewer polyunsaturated fatty acids (PUFA) and had a lower w6/w3 ratio. In experiment 3, three iso-N and iso-NE diets containing different varieties of lupin (Lupinus albus cv Lublanc and Amiga; Lupinus angustifolius cv Boltensia) and an a-galactosidase supplement were investigated in 12 pigs fitted with a caecal canula, as in Exp. 1. The results showed that the digestible protein supply by the Boltensia diet was higher than in the others. However, the Boltensia variety led to a higher urinary N excretion than the Lublanc variety. The results obtained with Amiga were intermediate. Consequently, the utilisation of ingested and digested proteins was relatively high with the Lublanc diet, intermediate with the Amiga diet and low with the Boltensia diet. The results suggested that the Lublanc variety was better adapted for pig feed that contained an a-galactosidase supplement. [less ▲]

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See detailResistance induced in cucumber and tomato by a non-pathogenic Pseudomonas putida strain
Adam, Akram; Jourdan, Emmanuel ULiege; Ongena, MARC ULiege et al

in Parasitica (2005), 61

Some plant growth promoting rhizobacteria are able to stimulate inducible defense mechanisms that render the host plant less susceptible to a subsequent pathogen attack. This phenomenon, called induced ... [more ▼]

Some plant growth promoting rhizobacteria are able to stimulate inducible defense mechanisms that render the host plant less susceptible to a subsequent pathogen attack. This phenomenon, called induced systemic resistance (ISR), can occur in several plant species against a wide range of bacterial, viral and fungal pathogens. Despite extensive work, many aspects of the molecular basis underlying this rhizobacteria-mediated ISR remain unclear. In this context, we have studied for several years the ISR-mediated protective effect of a particular strain, Pseudomonas putida BTP1. In this paper, we present the results obtained by using BTP1 for disease reduction against anthracnose caused by Colletotrichum lagenarium on cucumber and grey mold caused by Botrytis cinerea on tomato. As a result of cucumber treatment with BTP1, we observed an enhanced hydroperoxide lyase activity that could restrict pathogen ingress since this enzyme, acting downstream in the so-called oxylipin pathway, forms short chain aldehydes considered as “volatile phytoalexins”. By contrast, this phenomenon is not involved in the protective effect afforded by the strain in tomato. In this case, disease reduction is more seemingly associated with an early accumulation of antifungal compounds stimulated by the bacterium, showing that specific ISR-related metabolic pathways may be activated in different plants by the same microorganism. [less ▲]

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See detailL'évaluation des compétences, une entreprise impossible ? (Résolution de problèmes complexes et maîtrise de procédures mathématiques)
Crahay, Marcel ULiege; Detheux, Monique

in Mesure et Evaluation en Education [=MEE] (2005), 28(1), 57-58

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See detailPhosphatidylinositol 3,4,5-trisphosphate modulation in Ship2-deficient mouse embryonic fibroblasts
Blero, D.; Zhang, J.; Pesesse, X. et al

in FEBS Journal (2005), 272

SHIP2, the ubiquitous SH2 domain containing inositol 5-phosphatase, includes a series of protein interacting domains and has the ability to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate [PtdIns ... [more ▼]

SHIP2, the ubiquitous SH2 domain containing inositol 5-phosphatase, includes a series of protein interacting domains and has the ability to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] in vitro. The present study, which was undertaken to evaluate the impact of SHIP2 on PtdIns(3,4,5)P3 levels, was performed in a mouse embryonic fibroblast (MEF) model using SHIP2 deficient (– ⁄ –) MEF cells derived from knockout mice. PtdIns(3,4,5)P3 was upregulated in serum stimulated – ⁄ – MEF cells as compared to +⁄+ MEF cells. Although the absence of SHIP2 had no effect on basal PtdIns(3,4,5)P3 levels, we show here that this lipid was significantly upregulated in SHIP2 – ⁄ – cells but only after short-term (i.e. 5–10 min) incubation with serum. The difference in PtdIns(3,4,5)P3 levels in heterozygous fibroblast cells was intermediate between the +⁄+ and the – ⁄ – cells. In our model, insulin-like growth factor-1 stimulation did not show this upregulation. Serum stimulated phosphoinositide 3-kinase (PI 3-kinase) activity appeared to be comparable between +⁄+ and – ⁄ – cells. Moreover, protein kinase B, but not mitogen activated protein kinase activity, was also potentiated in SHIP2 deficient cells stimulated by serum. The upregulation of protein kinase B activity in serum stimulated cells was totally reversed in the presence of the PI 3-kinase inhibitor LY-294002, in both +⁄+ and – ⁄ – cells. Altogether, these data establish a link between SHIP2 and the acute control of PtdIns(3,4,5)P3 levels in intact cells [less ▲]

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See detailLa dissolution pour justes motifs: quel avenir?
Caprasse, Olivier ULiege; Aydogdu, Roman ULiege

in Revue Pratique des Sociétés Civiles et Commerciales (2005)

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See detailSécurité des aliments, HACCP et traçabilité
Anceau, Christine ULiege; Sindic, Marianne ULiege; Deroanne, Claude

in Troupeaux et Cultures des Tropiques (2005), VI(Année III), 54-57

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See detailLa notion de confiance mutuelle : l'"alpha" ou l'"oméga" d'une justice pénale européenne
Flore, Daniel ULiege

in La confiance mutuelle dans l'espace pénal européen (2005)

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See detailFrasnian carbonate buildups of southern Belgium: the Arche and Lion members interpreted as atolls
Boulvain, Frédéric ULiege; Demany, B.; Coen-Aubert, M.

in Geologica Belgica (2005), 8(1-2), 69-91

The facies architecture, sedimentary dynamics and paleogeographic evolution were reconstructed for a number of Frasnian buildups developed on a carbonate platform on the south side of the Dinant ... [more ▼]

The facies architecture, sedimentary dynamics and paleogeographic evolution were reconstructed for a number of Frasnian buildups developed on a carbonate platform on the south side of the Dinant Synclinorium (Belgium). Bed-by-bed sampling and detailed petrography were complemented by magnetic susceptibility analysis, allowing for high-precision lateral correlation. Six facies were recognised in the buildups, each characterized by a specific range of textures and assemblage of organisms: grey, pinkish or greenish limestone, with stromatactis, corals and stromatoporoids (facies A3-L3); grey limestone with corals, peloids and dasycladales (facies A4-L4); grey, microbial limestone (facies A5-L5); grey limestone with dendroid stromatoporoids (facies A6-L6); grey, laminar fenestral limestone, (facies A7-L7); grey, bioturbated limestone (facies A8-L8). The time-equivalent off -buildup sediments include a large amount of transported material that originally came from the buildups. Sedimentological evidence suggests that facies A3-L3 developed between the storm wavebase and the fairweather wavebase, in a oligophotic environment. This facies contains lenses of facies A5-L5, with stromatolitic coatings and Renalcis-rich thrombolitic bushes. These lenses were developed in greatest abundance closest to the fairweather wavebase, and they became anastomosing. Facies A6-L6 was developed in an environment with slightly restricted water circulation; there is a steady transition between this facies and the fenestral limestone A7-L7, which were deposited in a moderately protected subtidal to intertidal area. Facies A8-L8 developed at subtidal depths in a quiet, lagoonal environment. The buildups started with the development of facies A3-L3, with microbial lenses and algal facies becoming progressively more abundant upwards. Above about 20m in each buildup, more protected facies are found in the buildup’s central part. This atoll-like geometry suggests the development of restricted sedimentation in this central area, sheltered by bindstone or floatstone facies. The initial development of the lower part of a buildup during a transgression and subsequent highstand would have been followed by reefal growth along the edge of the buildup during the succeeding lowstand; an atoll crown would then have started to develop during the following transgressive stage. The presence of restricted facies can be seen as the consequence of the balance between sea level rise and reef growth. [less ▲]

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See detailParentification-Infantilisation
Stassart, Martine ULiege

in Thérapie Familiale (2005), 26(1), 36-53

The research on the double bind context helps us understand the individuation process of mothers who are described as parentified and whose child seems to present borderline or psychotic problems. In a ... [more ▼]

The research on the double bind context helps us understand the individuation process of mothers who are described as parentified and whose child seems to present borderline or psychotic problems. In a previous paper, we presented a study on double bind between those mothers and their child. The aim of this present paper is to develop the transgenerational aspects of those family patterns. The paper will describe the individuation process of the parentifed mother based on the position she had in her own family, the way she grew up and progressively developed. We will examine her functions towards each of her parents and as well as towards her sibling. We will focus on different elements such as contact style, pat¬terns of interaction in the creation of an « experiencing world » that is so crucial in double bind process. This paper is the last of four. They all tried to expand the area of double bind by clarifyinging the Bateson's metaphor about the double bind as the only visible part of an iceberg. Further than a logical conceptual organization for double bind patterns, the aim of this paper is to provide therapists with a methodological tool they could use as a map which is co-created with the family to progressively reveal the gond reasons for this pathological situation to be and question its pertinence in the family today. [less ▲]

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See detailBirth of a nucleolus: the evolution of nucleolar compartments.
Thiry, Marc ULiege; Lafontaine, Denis L J

in Trends in Cell Biology (2005), 15(4), 194-9

In eukaryotes, ribosome synthesis largely takes place in a specialized nuclear domain - the nucleolus. It has recently become apparent that this organelle is involved in the biogenesis of most cellular ... [more ▼]

In eukaryotes, ribosome synthesis largely takes place in a specialized nuclear domain - the nucleolus. It has recently become apparent that this organelle is involved in the biogenesis of most cellular ribonucleoprotein particles (RNPs), as well as in cell-cycle regulation, making it central to gene expression. The field has traditionally acknowledged that each nucleolus is organized in three morphologically distinct compartments. Here, however, we discuss our view that in fact many eukaryotes have bipartite nucleoli. We propose that, during evolution, a third nucleolar compartment emerged at the transition between the anamniotes and the amniotes, following a substantial increase in size of the rDNA intergenic region. We believe that these conclusions have important implications for understanding the structure-function relationships within this key cellular organelle. [less ▲]

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See detailEULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility
Conaghan, P.; D'Agostino, M. A.; Ravaud, P. et al

in Annals of the Rheumatic Diseases (2005), 64(12), 1710-1714

BACKGROUND: Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression. OBJECTIVE: To determine if ... [more ▼]

BACKGROUND: Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression. OBJECTIVE: To determine if decision rules can be devised from clinical findings and ultrasonography (US) to allow recognition of synovial inflammation in patients with painful knee OA. METHODS: A EULAR-ESCISIT cross sectional, multicentre study enrolled subjects with painful OA knee who had clinical, radiographic, and US evaluations. A classification and regression tree (CART) analysis was performed to find combinations of predictor variables that would provide high sensitivity and specificity for clinically detecting synovitis and effusion in individual subjects. A range of definitions for the two key US variables, synovitis and effusion (using different combinations of synovial thickness, depth, and appearance), were also included in exploratory analyses. RESULTS: 600 patients with knee OA were included in the analysis. For both knee synovitis and joint effusion, the sensitivity and specificity were poor, yielding unsatisfactory likelihood ratios (75% sensitivity, 45% specificity, and positive LR of 1.36 for knee synovitis; 71.6% sensitivity, 43.2% specificity, and positive LR of 1.26 for joint effusion). The exploratory analyses did not improve the sensitivity and specificity (demonstrating positive LRs of between 1.26 and 1.57). CONCLUSION: Although it is possible to determine clinical and radiological predictors of OA inflammation in populations, CART analysis could not be used to devise useful clinical decision rules for an individual subject. Thus sensitive imaging techniques such as US remain the most useful tool for demonstrating synovial inflammation of the knee at the individual level. [less ▲]

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See detailAndré Baillon et les enquêtes littéraires
Provenzano, François ULiege

in Nouveaux cahiers André Baillon (2005), 3

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See detailLa loi du 19 décembre 2003 relative aux infractions terroristes : Genèse, principes et conséquences
Flore, Daniel ULiege

in Questions d'actalité de droit pénal et de procédure pénale (2005)

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See detailChristine Geffers Browne : Theodor Storm. Das Spannungsverhältnis zwischen Glauben und Aberglauben in seinen Novellen.
Gerrekens, Louis ULiege

in Schriften der Theodor-Storm-Gesellschaft (2005), 54

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See detailMandat d’arrêt européen et remise des nationaux
Flore, Daniel ULiege

in European Arrest Warrant (2005)

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See detailThe callipyge mutation and other genes that affect muscle hypertrophy in sheep.
Cockett, Noelle E; Smit, Maria A; Bidwell, Christopher A et al

in Genetics, Selection, Evolution (2005), 37 Suppl 1

Genetic strategies to improve the profitability of sheep operations have generally focused on traits for reproduction. However, natural mutations exist in sheep that affect muscle growth and development ... [more ▼]

Genetic strategies to improve the profitability of sheep operations have generally focused on traits for reproduction. However, natural mutations exist in sheep that affect muscle growth and development, and the exploitation of these mutations in breeding strategies has the potential to significantly improve lamb-meat quality. The best-documented mutation for muscle development in sheep is callipyge (CLPG), which causes a postnatal muscle hypertrophy that is localized to the pelvic limbs and loin. Enhanced skeletal muscle growth is also observed in animals with the Carwell (or rib-eye muscling) mutation, and a double-muscling phenotype has been documented for animals of the Texel sheep breed. However, the actual mutations responsible for these muscular hypertrophy phenotypes in sheep have yet to be identified, and further characterization of the genetic basis for these phenotypes will provide insight into the biological control of muscle growth and body composition. [less ▲]

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See detailLa référence à Augustin chez Husserl
Seron, Denis ULiege

in Philosophique (2005)

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See detail5-Hydroxytryptamine 1A receptors, major depression, and suicidal behavior.
Pitchot, William ULiege; Hansenne, Michel ULiege; Pinto, Emmanuel ULiege et al

in Biological Psychiatry (2005), 58(11), 854-8

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are ... [more ▼]

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are available, however, regarding the possible specific role of 5-HT1A receptors in the biology of suicidality. Therefore, the aim of our study was to use a neuroendocrine strategy to test the hypothesis of a role for 5-HT1A receptors in the biology of suicidal behavior. METHODS: Hormonal (adrenocorticotropic hormone [ACTH], cortisol, prolactin [PRL]) and temperature responses after administration of flesinoxan, a highly potent and selective 5-HT1A receptor full agonist, were assessed in 40 inpatients with major depression, divided into two subgroups (20 suicide attempters and 20 nonattempters), compared with 20 normal control subjects matched for gender and age. RESULTS: Compared with nonattempters, suicide attempters exhibited significantly lower PRL (p = .01), cortisol (p = .014), and temperature (p = .0002) responses. Prolactin (p = .007), cortisol (p = .04), and temperature (p = .00003) responses were also decreased in suicide attempters compared with normal control subjects. In contrast, we did not observe any significant differences in hormonal or temperature responses to flesinoxan between depressed patients without a history of suicide attempt and normal control subjects. CONCLUSIONS: The present study tends to confirm the role of 5-HT and more specifically 5-HT1A receptors in the biology of suicidal behavior in major depression. [less ▲]

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See detailA case of sylvatic dermatophytosis due to Trichophyton mentagrophytes in a cat
Carlotti, D. N.; De Barbeyrac, P.; Mignon, Bernard ULiege et al

in Pratique médicale & chirurgicale de l'animal de compagnie (2005), 40

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See detailFibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin.
Lecut, Christelle ULiege; Feijge, Marion A H; Cosemans, Judith M E M et al

in Thrombosis and Haemostasis (2005), 94(1), 107-14

The role of collagens and collagen receptors was investigated in stimulating platelet-dependent thrombin generation. Fibrillar type-I collagens, including collagen from human heart, were most potent in ... [more ▼]

The role of collagens and collagen receptors was investigated in stimulating platelet-dependent thrombin generation. Fibrillar type-I collagens, including collagen from human heart, were most potent in enhancing thrombin generation, in a way dependent on exposure of phosphatidylserine (PS) at the platelet surface. Soluble, non-fibrillar type-I collagen required pre-activation of integrin alpha2beta1 with Mn2+ for enhancement of thrombin generation. With all preparations, blocking of glycoprotein VI (GPVI) with 9O12 antibody abrogated the collagen-enhanced thrombin generation, regardless of the alpha2beta 1 activation state. Blockade of alpha2beta1 alone or antagonism of autocrine thromboxane A2 and ADP were less effective. Blockade of alphaIIbbeta3 with abciximab suppressed thrombin generation in platelet-rich plasma, but this did not abolish the enhancing effect of collagens. The high activity of type-I fibrillar collagens in stimulating GPVI-dependent procoagulant activity was confirmed in whole-blood flow studies, showing that these collagens induced relatively high expression of PS. Together, these results indicate that: i) fibrillar type-I collagen greatly enhances thrombin generation, ii) GPVI-induced platelet activation is principally responsible for the procoagulant activity of fibrillar and non-fibrillar collagens, iii) alpha2beta1 and signaling via autocrine mediators facilitate and amplify this GPVI activity, and iv) alphaIIbbeta3 is not directly involved in the collagen effect. [less ▲]

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See detailCystic lesion of the parotid following drug-induced toxic epidermal necrolysis (Lyell's syndrome).
Paquet, Philippe ULiege; Jacob, E.; Pierard, Gérald ULiege

in Journal of Oral Pathology & Medicine (2005), 34(6), 380-2

A 32-year-old woman developed a unilateral cyst of the duct of parotid gland 4 months after severe oral involvement of drug-induced toxic epidermal necrolysis (TEN). The pathomechanism leading to the TEN ... [more ▼]

A 32-year-old woman developed a unilateral cyst of the duct of parotid gland 4 months after severe oral involvement of drug-induced toxic epidermal necrolysis (TEN). The pathomechanism leading to the TEN epidermal destruction had presumably involved the salivary epithelium as well, leading to the development of the cystic lesion. The patient had low serum lipase levels, but high serum amylase levels at the time of TEN. These serological markers could represent a clue for the risk of developing cystic lesions of the large salivary glands following TEN. [less ▲]

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See detailSimenon en situation
Denis, Benoît ULiege; Dubois, Jacques ULiege

in Lendemains (2005), (117), 71-82

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See detailThe nail under fungal siege in patients with type II diabetes mellitus.
Pierard, Gérald ULiege; Pierard, Claudine ULiege

in Mycoses (2005), 48(5), 339-42

Few studies have examined the prevalence of onychomycosis among diabetic patients. Given the morbidity linked to onychomycosis, and the ever-growing size of the diabetic population, a better recognition ... [more ▼]

Few studies have examined the prevalence of onychomycosis among diabetic patients. Given the morbidity linked to onychomycosis, and the ever-growing size of the diabetic population, a better recognition of this nail infection is welcome. To revisit the relative prevalence of dermatophyte, yeast and non-dermatophytic mould onychomycoses in diabetic adults in a prospective study using combined histomycology and cultures. Toenail clippings were collected for 3 years in 190 type II diabetic patients (136 men and 54 women) and from an age- and gender-matched group of non-diabetic subjects. All sampled nails showed clinical alterations reminiscent of onychomycosis. Histomycology and cultures were performed on each sample to distinguish onychomycosis from non-infectious onychodystrophy. Compared to non-diabetic subjects with nail alterations, diabetics showed a higher proportion of onychomycosis relative to non-fungal onychodystrophy. Diabetic men suffered more frequently from onychomycosis and onychodystrophy than diabetic women. When considering the nature of the fungal pathogens, dermatophytes predominated largely over yeast and non-dermatophytic moulds, both in diabetic and non-diabetic patients. Diabetic patients, particularly men, are at increased risk of developing onychomycosis. The morbidity linked to this disorder, and its impact on the foot status in diabetic subjects merit to be better appreciated by clinicians. [less ▲]

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See detailEndemic alveolar echinococcosis in southern Belgium?
Detry, Olivier ULiege; Honore, Charles ULiege; Delwaide, Jean ULiege et al

in Acta Gastro-Enterologica Belgica (2005), 68(1, Jan-Mar), 1-4

Until now, Belgium has been considered as a low-risk country for alveolar echinococcosis. However it was recently demonstrated by necropsy series that, in some parts of southern Belgium (Wallonia), up to ... [more ▼]

Until now, Belgium has been considered as a low-risk country for alveolar echinococcosis. However it was recently demonstrated by necropsy series that, in some parts of southern Belgium (Wallonia), up to 51% of the red foxes (Vulpes vulpes) may be infected by E. multilocaris. The authors, working in a university hospital in southern Belgium, described in 2002 the first autoctuthonous Belgian case of hepatic alveolar echinococcosis. More importantly, in 2004, they diagnosed three other patients with alveolar echinococcosis. One underwent surgical resection, but two others had bilateral pulmonary involvement at time of definite diagnosis. Palliative albendazole therapy was initiated. These patients had been diagnosed with hepatic mass from unknown origin for several months. The previous experience with the first case allowed the authors to consider and to confirm alveolar echinococcosis diagnosis, made by pathology and/or serological tests and imaging. These four patients with alveolar echinococcosis were living either in the Liege or the Luxembourg province. Considering the high prevalence of E. multilocaris infection of red foxes and the recent increase of the fox population due to rabies vaccination in southern Belgium, and also the presence of E. multilocaris infection of red foxes in northern Belgium, it is likely that not only Wallonia, but also maybe the whole Belgium, may face endemic alveolar echinococcosis in the next years. [less ▲]

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See detailComment je préviens ... par des soins dermo-cosmetiques, l'expression d'une acné qui couve.
Pierard, Gérald ULiege; Pierard, Claudine ULiege

in Revue Médicale de Liège (2005), 60(9), 741-3

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ... [more ▼]

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ranging from discrete to severe. The lesions may be sporadic or follow a wild course. The therapeutic strategy depends on these progression characteristics and must fit to each individual patient. This review focuses on the minor but the most frequent types of acne that may benefit from dermocosmetic treatments. [less ▲]

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See detailOn the influence of misclassified data on results of goodness of fit testing
Magis, David ULiege

in Statistical Methodology (2005), 2

In this paper we focus on the chi-square test of goodness of fit, which compares an observed discrete distribution to an expected known one. We show that the results of this test, using the common Pearson ... [more ▼]

In this paper we focus on the chi-square test of goodness of fit, which compares an observed discrete distribution to an expected known one. We show that the results of this test, using the common Pearson statistic, are very sensitive to misclassified observations between two or more categories. We also propose a general rule of thumb for analysing data set stability with respect to such classification errors. Practical analysis of a real example illustrates our purpose. [less ▲]

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See detailQuantification of dandruff adherence to hair.
Pierard, Claudine ULiege; Uhoda, Emmanuelle ULiege; Pierard, Gérald ULiege

in International Journal of Cosmetic Science (2005), 27(5), 279-82

Dandruff adherence to hair shafts is a visible annoying phenomenon. The aspect can be recorded by different means including the ultraviolet light-enhanced visualization (ULEV) method and microscopy. We ... [more ▼]

Dandruff adherence to hair shafts is a visible annoying phenomenon. The aspect can be recorded by different means including the ultraviolet light-enhanced visualization (ULEV) method and microscopy. We present another quantitative method. Hairs were clipped from the parietal scalp area of 25 volunteers complaining of dandruff. They were firmly applied onto cyanoacrylate-coated microscopic slides. Hairs were lifted up after 15-20 s leaving a cast in the adhesive coat. Dandruff were thus harvested from the hair shafts and remained attached to the cyanoacrylate coat. After staining, the material was submitted to image analysis to derive the dandruff density per unit length of hairs. In 11/25 subjects, a correlation was found between the width of the hair casts and the dandruff density. This method does not collect all dandruff along hair shafts, but data are likely representative of the whole corneocyte load. [less ▲]

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See detailValorisation des petits bois rouges en Région wallonne
Hebert, Jacques ULiege; Bailly, Francine; Brunin, Emmanuelle et al

in Forêt Wallonne (2005), 75(75), 19-31

La forêt wallonne offre aujourd'hui une quantité limitée mais cependant significative de bois rouges de petites dimensions. Malheureusement, ceux-ci ne trouvent généralement pas acquéreur à des prix ... [more ▼]

La forêt wallonne offre aujourd'hui une quantité limitée mais cependant significative de bois rouges de petites dimensions. Malheureusement, ceux-ci ne trouvent généralement pas acquéreur à des prix raisonnables. Cet état de fait tient à une série de griefs, justifiés ou non, attribués à ces produits et sur lesquels nous souhaitons nous arrêter ici. [less ▲]

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See detailControlled radical polymerization of vinyl acetate based on cobalt(II) acetyl acetonate
Debuigne, Antoine ULiege; Detrembleur, Christophe ULiege; Caille, Jean-Raphaël et al

in Chimie Nouvelle (2005)

Controlled radical polymerization (CRP) is a valuable strategy to design a large range of polymers with well defined molecular characteristics under non very demanding conditions. However, the known CRP ... [more ▼]

Controlled radical polymerization (CRP) is a valuable strategy to design a large range of polymers with well defined molecular characteristics under non very demanding conditions. However, the known CRP techniques, such as nitroxide mediated polymerization (NMP), atom transfer radical polymerization (ATRP) and radical addition-fragmentation chain transfer polymerization (RAFT), suffer from limitations, including a moderate control on the vinyl acetate polymerization. Within the search for new controlled radical polymerization processes, we designed a system based on the reversible combination of growing macroradicals with a cobalt(II)acetylacetonate complex which provides an effective control of the vinyl acetate polymerization even when carried out in suspension in water. In a macromolecular engineering effort, well-defined end-functional poly(vinyl acetate), and poly(vinyl acetate) or poly(vinyl alcohol) containing block copolymers have been synthesized. [less ▲]

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