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See detailJupiter's equatorward auroral features: possible signatures of magnetospheric injections
Dumont, Maïté ULg; Grodent, Denis ULg; Radioti, Aikaterini ULg et al

in Journal of Geophysical Research - Space Physics. (in press)

The present study investigates the characteristics of ultraviolet auroral features located equatorward of the main emission appearing in Hubble Space Telescope images of the northern and southern Jovian ... [more ▼]

The present study investigates the characteristics of ultraviolet auroral features located equatorward of the main emission appearing in Hubble Space Telescope images of the northern and southern Jovian hemispheres obtained in 2000-2007. On average, one feature is observed every day, but several auroral structures are occasionally seen over a wide range of local times in the same image. Several properties of these features are analyzed, such as their location, emitted power and lifetime. Additionally, we magnetically map the auroral features to the equatorial plane using the VIPAL model in order to compare their observed properties with those of magnetospheric injections detected by the Galileo spacecraft. The equatorward auroral features show up between the Io footpath and the main auroral emission, at all System III longitudes, in agreement with Galileo measurements. Moreover, we compare the magnetic flux associated with these features with estimates of the out-going flux related to the radial transport of plasma in the Jovian magnetosphere and we find that they could account for at least one third of this flux. This comparative study shows that the auroral features under study are most probably related to magnetospheric injections and thus sheds light on the processes involved in the magnetosphere-ionosphere dynamics. [less ▲]

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See detailAnalysis of shrinkage effect on mass transfer during the convective drying of sawdust/sludge mixtures
Li, Jie; Bennamoun, Lyes; Fraikin, Laurent ULg et al

in Drying Technology (in press)

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See detailThe role of mesenchymal stem cells in the treatment of ulcerative colitis and Crohn's disease
GREGOIRE, Céline ULg; Louis, Edouard ULg; BRIQUET, Alexandra ULg et al

in The Biology and Therapeutic Applications of Mesenchymal Cells (in press)

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailSoutenir le développement des compétences des enseignants du supérieur par la documentation, l’investigation et le partage des pratiques en classe
Poumay, Marianne ULg; Georges, François ULg

in Dossiers des Sciences de l'Education (Les) (in press)

L’article aborde le développement professionnel des enseignants à travers un master complémentaire en pédagogie de l’enseignement supérieur. Orientée recherche, cette formation met en œuvre les principes ... [more ▼]

L’article aborde le développement professionnel des enseignants à travers un master complémentaire en pédagogie de l’enseignement supérieur. Orientée recherche, cette formation met en œuvre les principes du courant « SoTL ». Elle préconise une documentation de ses pratiques, une investigation de type scientifique de l’apprentissage des étudiants dans sa propre classe et une production de connaissance par le partage de ses avancées. Les articles de régulation rédigés à l’issue de la formation par une cohorte de dix participants montrent leur réelle inscription dans ce courant « SoTL » ; une enquête donne par ailleurs des indices d’efficacité de la formation sur ces mêmes critères à moyen terme. [less ▲]

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See detailSens et signification dans l'esthétique de Mallarmé
Durand, Pascal ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press), 5

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See detailLe Laboratoire d’Analyse statistique des langues anciennes : cinquante années de recherches
Longrée, Dominique ULg

in Etudes Classiques (Namur, Belgium) (in press)

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See detailCOMMENT JE TRAITE ... L’arrêt cardio-respiratoire extrahospitalier : la fenêtre du centraliste 112
STIPULANTE, Samuel ULg; ZANDONA, Régine; EL-FASSI, Mehdi ULg et al

in Revue Médicale de Liège (in press), 69

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See detailDominant amphipods of Posidonia oceanica seagrass meadows display considerable trophic diversity
Michel, Loïc ULg; Dauby, Patrick ULg; Gobert, Sylvie ULg et al

in Marine Ecology (in press)

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica ... [more ▼]

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica seagrass meadows and to highlight trophic diversity among this community. Our results indicate that, although all dominant species heavily relied on macroalgal epiphytes, considerable interspecific dietary differences existed. Carbon stable isotope ratios notably showed that some of the amphipod species favored grazing on epiphytes from leaves or litter fragments (Apherusa chiereghinii, Aora spinicornis, Gammarus aequicauda), while others like Dexamine spiniventris preferred epiphytes from rhizomes. The remaining amphipods (Caprella acanthifera, Ampithoe helleri and Gammarella fucicola) readily consumed both groups. In addition, SIAR modeling suggested that most species had a mixed diet, and relied on several food items. Fatty acid analysis and gut contents revealed that contribution of microepiphytic diatoms and of benthic and suspended particulate organic matter to the diet of amphipods were anecdotal. None of the examined species seemed to graze on their seagrass host (low 18:2(n-6) and 18:3(n-3) fatty acids contents), but G. aequicauda partly relied on seagrass leaf detritus, as demonstrated by the lesser 13C-depletion of their tissues. Overall, our findings suggest that amphipods, because of their importance in transfers of organic matter from primary producers and detritus to higher rank consumers, are key-items in P. oceanica associated food webs. [less ▲]

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See detailOccurrence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary, Argentina, and their mid-distance movements along the Northeast Patagonian coast
Failla, Mauricio; Seijas, Veronica; Vermeulen, Els ULg

in Latin American Journal of Aquatic Mammals (in press)

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data ... [more ▼]

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data on the dolphin’s activity patterns were gathered via an Ad Libitum focal group sampling mode accompanying dorsal fin images taken for identification and re-identification of individuals. A total effort of 188 h resulted in 58 h of positive observation of 124 dolphin groups (sightings per unit effort (SPUE) = 0.66 groups/h). Data analysis showed two main activity states for the observed groups, travelling (65%) and foraging (26%). The remaining 9% of the groups were involved in other activity states. The photo-identification effort, which started opportunistically in 2006, resulted in a catalogue of 21 individual dolphins, with a total mean re-identification rate of 9 days (max = 24 days). When comparing these pictures to the existing catalogue of Bahía San Antonio (approximately 200 km west from the study area) dorsal fins of 20 individuals could be positively matched and most (n = 17) could be subsequently re-identified in both areas, indicating their long distance movements along the North Patagonian coast during the austral autumn months. This season coincides with the lowest amount of feeding activity observed in Bahía San Antonio. This study suggests that bottlenose dolphins enter RNE, mainly during autumn, to forage. It appears that the search for food resources may be the trigger for their movement patterns along the North Patagonian coast during this season, at least for certain individuals. More research is needed to accurately confirm this hypothesis. [less ▲]

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See detailPrévention et promotion de la santé : quels modèles pour soutenir l’évolution des pratiques en soins de santé primaires ?
Vanmeerbeek, Marc ULg; Mathonet, Julien; Miermans, Marie-Christine ULg et al

in Presse Médicale (in press)

Objectives Published operating models about preventive health care and health promotion in primary care were sought with the aim of 1) compiling a functional inventory; and 2) to formulate working ... [more ▼]

Objectives Published operating models about preventive health care and health promotion in primary care were sought with the aim of 1) compiling a functional inventory; and 2) to formulate working hypotheses for the improvement of clinical practice towards more efficiency and more equity. Methods Narrative literature review, using keywords related to the various prevention classes, health promotion, primary care, practice models and health care delivery. The diversity of models led to a multi-criteria analysis. Results Twelve models were selected. Their characteristics were unevenly distributed. The models, whose authors announce that they apply to prevention, mainly describe approaches that focus on individuals within physician-patient relationship, and take into account practice organization. Some socio ecological and systems models illustrate health promotion: educational practice, group- or population-based targets, community environment and social determinants of health. There is little room for patients in elaborating the models, as they have little role in health care systems. The definitions of prevention, health promotion and patient education greatly differ from one model to another. Discussion Little is known about practical implementation of the models; assessment data are scarce. Some elements valued by health promotion could be integrated to health care: empowerment of citizens, addressing community environment; increased involvement in local health professionals’ networks; integration of individual and collective approaches within the same health care facilities to address simultaneously individual customization, efficiency and equity objectives. Conclusion These developments may call for adaptation in vocational training and continuous professional development: communication skills, awareness to public health concepts, and early and longitudinal exposure to community-based learning experiences for students. [less ▲]

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULg; Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailLaboratory challenges in primary aldosteronism screening and diagnosis
Rehan, Muhammad; Raizman, Joshua; CAVALIER, Etienne ULg et al

in Clinical Biochemistry (in press)

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See detailDetection of differential item functioning using the lasso approach
Magis, David ULg; Tuerlinckx, Francis; De Boeck, Paul

in Journal of Educational & Behavioral Statistics (in press)

This paper proposes a novel approach to detect differential item functioning (DIF) among dichotomously scored items. Unlike standard DIF methods that perform an item-by-item analysis, we propose the “LR ... [more ▼]

This paper proposes a novel approach to detect differential item functioning (DIF) among dichotomously scored items. Unlike standard DIF methods that perform an item-by-item analysis, we propose the “LR lasso DIF method”: logistic regression (LR) model is formulated for all item responses. The model contains item specific intercepts, an effect of the sum score and item-group interaction (i.e. DIF) effects, with a lasso penalty on all DIF parameters. Optimal penalty parameter selection is investigated through several known information criteria (AIC, BIC and cross-validation) as well as through a newly developed alternative. A simulation study was conducted to compare the global performance of the suggested “LR lasso DIF” method to the logistic regression and Mantel-Haenszel methods (in terms of false alarm and hit rates). It is concluded that for small samples the LR lasso DIF approach globally outperforms the logistic regression method, and also the Mantel-Haenszel method, especially in the presence of item impact, while it yields similar results with larger samples. [less ▲]

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See detailRôle et langue de Tchantchès dans les représentations en castelets des romans de chevalerie : le cas des Quatre fils Aymon
Baiwir, Esther ULg; Impe, Anaëlle

in Enquêtes du Musée de la Vie Wallonne (in press)

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du ... [more ▼]

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du répertoire liégeois ? Quels sont ses moyens d'action, mais également ses modes d'expression ? Divers registres de langue apparaissent au fil des spectacles ; quels sont ceux prêtés à notre héros ? Et surtout, ce rôle et cette langue ont-ils évolué au fil du temps ? C’est à ces quelques questions que nous tentons de répondre, en observant les différentes interventions de Tchantchès dans les réécritures des aventures des quatre fils Aymon, l’une des œuvres les plus anciennes et les plus fréquemment jouées dans les théâtres liégeois dévolus aux comédiens de bois. [less ▲]

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See detailWhen women support the patriarchal family. The dynamics of marriage in a Gécamines mining camp (Katanga province, DR Congo)
Rubbers, Benjamin ULg

in Journal of Historical Sociology (in press)

Based on ethnographic research among the ex-Gécamines workers of Panda (Likasi, DR Congo), this article studies the dynamics of the spousal relationship in a post-industrial context that has been long ... [more ▼]

Based on ethnographic research among the ex-Gécamines workers of Panda (Likasi, DR Congo), this article studies the dynamics of the spousal relationship in a post-industrial context that has been long characterized by paternalism. The results of this research suggest that, though men and women living in this mining community talk about their spousal relationships by invoking the ideal of Christian marriage promoted during the colonial period, in practice such relationships faced important changes following Congolese independence in 1960. The nationalization and subsequent dramatic decline of Gécamines caused changes which directly affected three central dimensions of the colonial family model, namely monogamy, the ideal of domesticity, and male authority. If men and women continue to reference this model, it is because, in times of growing poverty, it allows spouses to remind one other of their respective duties as docile housewives and responsible husbands, and to command respect as virtuous Christian families in the local community. [less ▲]

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See detailSequential decision-making approach for quadrangular mesh generation
Johnen, Amaury ULg; Ernst, Damien ULg; Geuzaine, Christophe ULg

in Engineering with Computers (in press)

A new indirect quadrangular mesh generation algorithm which relies on sequential decision-making techniques to search for optimal triangle recombinations is presented. In contrast to the state-of-art ... [more ▼]

A new indirect quadrangular mesh generation algorithm which relies on sequential decision-making techniques to search for optimal triangle recombinations is presented. In contrast to the state-of-art Blossom-quad algorithm, this new algorithm is a good candidate for addressing the 3D problem of recombining tetrahedra into hexahedra. [less ▲]

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See detailRevisiting the origin and diversification of vascular plants through a comprehensive Bayesian analysis of the fossil record
Silvestro, Daniel; Cascales - Miñana, Borja ULg; Bacon, Christine D. et al

in New Phytologist (in press)

Plants have a long evolutionary history, during which mass extinction events dramatically affected Earth’s ecosystems and its biodiversity. The fossil record can shed light on the diversi- fication ... [more ▼]

Plants have a long evolutionary history, during which mass extinction events dramatically affected Earth’s ecosystems and its biodiversity. The fossil record can shed light on the diversi- fication dynamics of plant life and reveal how changes in the origination–extinction balance have contributed to shaping the current flora. We use a novel Bayesian approach to estimate origination and extinction rates in plants throughout their history. We focus on the effect of the ‘Big Five’ mass extinctions and on estimating the timing of origin of vascular plants, seed plants and angiosperms. Our analyses show that plant diversification is characterized by several shifts in origination and extinction rates, often matching the most important geological boundaries. The estimated origin of major plant clades predates the oldest macrofossils when considering the uncertainties associated with the fossil record and the preservation process. Our findings show that the commonly recognized mass extinctions have affected each plant group differently and that phases of high extinction often coincided with major floral turnovers. For instance, after the Cretaceous–Paleogene boundary we infer negligible shifts in diversification of non-flowering seed plants, but find significantly decreased extinction in spore-bearing plants and increased origination rates in angiosperms, contributing to their current ecological and evolutionary dominance. [less ▲]

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See detailProgress on research on rodents and rodent-borne zoonoses in Southeast Asia
Blasdell, Kim; Bordes, Frédéric; Chaisiri, Kittipong et al

in Wildlife Research (in press)

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne ... [more ▼]

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne diseases. Recent studies concerning the Rattini tribe have identified unclear species boundaries that would benefit from further investigation. The development of barcoding may allow more accurate identification of rodents, specifically for complex species. However, knowledge on the distribution and habitat specializations of many common murine rodents is still scarce, particularly regarding the specific habitat preferences of most synanthropic rodent species (Rattus tanezumi or Rattus exulans). Several studies have analyzed the prevalence of major rodent-borne diseases in Southeast Asia and it appears that the greatest risk of rodent zoonoses are in the lowland rainfed and irrigated landscapes, generally in and around rice fields. [less ▲]

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See detailLa sécurité affective chez l'enfant en milieu résidentiel : Des soins du corps au bien être émotionnel
Aprile, Pauline ULg; Englebert, Jérôme ULg; Gauthier, Jean-Marie ULg

in Evolution Psychiatrique (in press)

Objectives - This review studies the concept of affective security in children living outside of their family environment by a brief exposition of its practical illustration in institution. We want to ... [more ▼]

Objectives - This review studies the concept of affective security in children living outside of their family environment by a brief exposition of its practical illustration in institution. We want to show that sufficient affective security can be achieved even in children institutionalized with major attachment difficulties. Method - We will first examine the original meaning of the concept by a theoretical review of its evolution over the years in the literature. Then, we will consider various questions concerning the legitimacy of institutionalization in link with affective security through a case analysis illustrating the issue. We will finally end by mentioning the main practical implications about the optimization of affective security in children institutionalized. Results - It is foremost by the predictable and expected daily acts posed by the professional caregivers in institution that the child may find sufficient affective security, generating emotional well-being and ultimately, an overall adequate development. Discussion – Children early separated from their family home to be placed in residential institution most often suffer from serious difficulties in terms of attachment to others. In this context, the institution has to deal with a specifically challenge: that is, to help the child to (re-)find sufficient internal security to allow him to grow on solid foundations. The institutional life which replaces family life primarily consists of an organizational structure that seeks to make child life as predictable as possible so that it has the necessary daily benchmarks to evolve adequately. Conclusion – In the everyday life in institution, the professionals struggling with children’s attachment disorders constantly try to achieve a right emotional-body balance through their psycho-educational practices with the child deprived of secure attachment strategies. [less ▲]

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See detailError analysis of generalized-alpha Lie group time integration methods for constrained mechanical systems
Arnold, Martin; Bruls, Olivier ULg; Cardona, Alberto

in Numerische Mathematik (in press)

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order ... [more ▼]

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order systems in linear spaces. Recently, they were extended to constrained systems in flexible multibody dynamics that have a configuration space with Lie group structure. In the present paper, the convergence of these Lie group methods is analysed by a coupled one-step error recursion for differential and algebraic solution components. It is shown that spurious oscillations in the transient phase result from order reduction that may be avoided by a perturbation of starting values or by index reduction. Numerical tests for a benchmark problem from the literature illustrate the results of the theoretical investigations. [less ▲]

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See detailThe ideology of the British National Party
Jamin, Jérôme ULg

in Revue LISA : Littératures, Histoire des Idées, Images, Sociétés du Monde Anglophone = LISA e-Journal (in press)

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See detailDe l’usage de la photographie dans une enquête ethno-sociologique sur la mémoire de l’exil et de l’immigration espagnols en Belgique
Molina Marmol, Maïté ULg

in RELAIS Revue du laboratoire d'études et de recherches sur l'interculturel (in press)

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See detailA Systematic Review of Cost-Effectiveness Analyses of Drugs for Postmenopausal Osteoporosis.
Hiligsmann, Mickaël ULg; Evers, Silvia M.; Ben Sedrine, Wafa et al

in PharmacoEconomics (in press)

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal ... [more ▼]

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal osteoporosis remains and even increases. OBJECTIVE: This study aims to identify all recent economic evaluations on drugs for postmenopausal osteoporosis, to critically appraise the reporting quality, and to summarize the results. METHODS: A literature search using Medline, the National Health Service Economic Evaluation database and the Cost-Effectiveness Analysis Registry was undertaken to identify original articles published between January 1, 2008 and December 31, 2013. Studies that assessed cost effectiveness of drugs in postmenopausal osteoporosis were included. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement was used to assess the quality of reporting of these articles. RESULTS: Of 1,794 articles identified, 39 studies fulfilled the inclusion criteria. They were conducted in 14 different countries and nine active interventions were assessed. When compared with no treatment, active osteoporotic drugs were generally cost effective in postmenopausal women aged over 60-65 years with low bone mass, especially those with prior vertebral fractures. Key drivers of cost effectiveness included individual fracture risk, medication adherence, selected comparators and country-specific analyses. Quality of reporting varied between studies with an average score of 17.9 out of 24 (range 7-21.5). CONCLUSION: This review found a substantial number of published cost-effectiveness analyses of drugs in osteoporosis in the last 6 years. Results and critical appraisal of these articles can help decision makers when prioritizing health interventions and can inform the development of future economic evaluations. [less ▲]

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See detailCT SCAN FEATURES OF PRESUMPTIVE HAEMORRHAGIC STROKE IN A DOG WITH CUSHING’S DISEASE
Liotta, Annalisa Pia ULg; Cavrenne, Romain; Peeters, Dominique ULg et al

in Case reports in Veterinary Medicine (in press)

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See detailL’acte incendiaire, son sujet et sa signification : propositions à partir du Saint Genet de Jean-Paul Sartre
Englebert, Jérôme ULg

in Annales Médico-Psychologiques (in press)

Objectives In this paper we studied fire setters with the hermeneutics’ method from the philosophy of Jean-Paul Sartre. In the psychobiography of Jean Genet, the philosopher raises issues of the ... [more ▼]

Objectives In this paper we studied fire setters with the hermeneutics’ method from the philosophy of Jean-Paul Sartre. In the psychobiography of Jean Genet, the philosopher raises issues of the infractional acting and its social meaning. Methods After recalling the basic notions of international literature about fire setters (including confusion with pyromania, diagnostic problems proposed by the DSM IV and the concept of "communicative arson"), we propose phenomenological and existential clues to discuss the act and its meaning. It is the unlawful act that is analysed and more specifically the arson. We propose different analysis than the psychic causality which is inspired by psychoanalysis. The criminogenesis gives way to a questioning of identity, about the place of fire in the subject’s history and within its relationships to others. As proposed by Sartre, the paradigm of this research is to consider the meaning "as the return of the future in the present". The second field of this study is an analysis of three clinical cases. These cases are the result of a forensic practice. The method is focused on the analysis of a narrative and autobiographical production. By this way we studied the temporal process of these three arsonists. Results A comparative reading of the psychobiography of Jean Genet written by Sartre and of the situation of arsonists gives accurate information. The "criminogenesis" gives way to a questioning of identity. In this way we discuss the meaning of fire in the subject's history and within its relationship to others. We highlight the inscription of the act in the social and constitutive process of the individual. From the clinical material, the author demonstrates a link between arson and construction of identity. Identity is considered as a dialectic between “ipse” and “idem”, as suggested by Ricœur. We can therefore consider the real sense that the arson has from the perspective of the actor but also from the viewpoint of the society and these conceptions may be similar or different. In clinical practice, we recommend to pay special attention to how the fire is part of the biography of the patient. Conclusions The fascination for fire is a source of meaning which can be radically different depending on whether we consider the external interpreter (the world or the clinician) or the author of the action. The basic principles of hermeneutics, as described by Gadamer and Ricœur, are to demonstrate that the understanding and the interpretation are not only the methods used in the human sciences but are also part of the fundamental processes inherent in human nature. Hermeneutics in general is the opposite of a doctrine of truth. It rather seeks to show arbitrarily how the interpretation and the search for meaning are paradigmatic of the human experience. [less ▲]

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See detailThe “Tuchlein” Colours in the Strasbourg Family Text: Recipes for Anthocyanin Pigments
Neven, Sylvie ULg; Sanyova, Jana

in Dyes in History and Archaeology (in press)

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See detailLa flexicurité : une politique des idées ? Regards croisés d’acteurs institutionnels belges en 2013
Beuker, Laura ULg; Gérard, Julie ULg; Orianne, Jean-François ULg

in Revue Belge de Sécurité Sociale (in press)

Cette recherche porte sur la traduction, en Belgique, d’une politique européenne de l’emploi – la flexicurité – par différents acteurs institutionnels. À partir d’une analyse documentaire et d’une ... [more ▼]

Cette recherche porte sur la traduction, en Belgique, d’une politique européenne de l’emploi – la flexicurité – par différents acteurs institutionnels. À partir d’une analyse documentaire et d’une vingtaine d’entretiens semi-directifs, nous étudierons la manière dont ces acteurs s’approprient et interprètent la flexicurité. Nous nous appuierons principalement sur les apports récents de la sociologie de l’action publique, en particulier l’approche cognitive des politiques publiques (Surel, 2000 ; Muller et Surel, 1998) et l’européanisation des politiques d’emploi (Palier et Surel, 2007 ; 2010). Nous montrerons que cette appropriation a donné lieu, en Belgique, à une transformation du sens conféré à la sécurité, dorénavant assimilée à de la flexibilité. [less ▲]

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See detailNutritive value of Adenodolichos rhomboideus leaves compared with Leucaena leucocephala and Stylosanthes guianensis forages in indigenous goats in Lubumbashi (DR Congo).
Tshibangu, Muamba Innocent; Nsahlai, Ignatus Verla; Kiatoko, Mangeye Honoré et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Forage from three species (Adenodolichos rhomboideus, Leucaena leucocephala, Stylosanthes guianensis) were evaluated by determining chemical composition, voluntary intake and apparent in vivo ... [more ▼]

Forage from three species (Adenodolichos rhomboideus, Leucaena leucocephala, Stylosanthes guianensis) were evaluated by determining chemical composition, voluntary intake and apparent in vivo digestibility of dry matter (DM), organic matter (OM), crude protein (CP), neutral detergent fibre (NDF) and acid detergent fibre (ADF). Six goats (17.1±0.7 kg) were used in 3 x 3 double latin square design to determine the digestibility and intake of the three forages. Forage from S. guianensis had lower (p<0.001) CP content than L. leucocephala forage and A. rhomboideus leaves. Fibres content (ADF and NDF) were lower (p<0.001) in L. leucocephala (35%) forage than A. rhomboideus (59.5%) leaves and S. guianensis forages (56.5%). L. leucocephala forage was superior in CP, Ash, EE concentrations, digestibility and voluntary intake of CP. A. rhomboideus leaves had lower (p<0.05) apparent digestibility and intake of DM. Digestible CP intake were similar between A. rhomboideus leaves and S. guianensis forages. Low digestibility and voluntary intake of A. rhomboideus leaves may be due to negative effect of anti-nutritional factor such as tannin. Digestible CP was similar for A. rhomboideus leaves and S. guianensis forage. [less ▲]

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See detailcompte rendu de : Luca MARTORELLI, Ps. Aurelii Augustini regulae
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (in press)

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See detailFonctionnement exécutif et réseaux cérébraux
Collette, Fabienne ULg; Salmon, Eric ULg

in Revue de Neuropsychologie, Neurosciences Cognitives et Cliniques (in press)

Depuis les observations initiales de Luria [1], la localisation cérébrale du fonctionnement exécutif a fait l’objet de nombreux travaux de recherche. Dans un premier temps, les études de patients cérébro ... [more ▼]

Depuis les observations initiales de Luria [1], la localisation cérébrale du fonctionnement exécutif a fait l’objet de nombreux travaux de recherche. Dans un premier temps, les études de patients cérébro-lésés ont mis en évidence l’implication prédominante des régions frontales. Avec l’avènement des techniques modernes d’imagerie cérébrale (tomographie à émission de positons [TEP] et imagerie par résonnance magnétique fonctionnelle [IRMf], il est toutefois apparu que le fonctionnement exécutif était sous-tendu par un réseau antéro-postérieur largement distribué. Dès ce moment, l’attention s’est portée sur le rôle exact des différentes régions impliquées lors de la réalisation d’épreuves exécutives et sur l’importance relative des régions antérieures et postérieures. Plus récemment, l’étude du fonctionnement exécutif en tant que réseau de régions fonctionnellement connectées s’est développée, et on a également commencé à s’intéresser à l’influence des aspects cérébraux structurels et des caractéristiques génétiques. Les résultats de ces travaux soulignent l’aspect interactif et fortement modulable du fonctionnement exécutif au niveau cérébral, et la nécessité de prendre en compte simultanément différents niveaux d’analyse. Nous aborderons dans cette revue ces différentes thématiques, en nous centrant sur les données issues d’études chez le sujet jeune et sain pour des raisons de concision. [less ▲]

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See detailEVALUATION OF A RAPID BEDSIDE SCORING SYSTEM FOR MICROCIRCULATION VIDEOS ACQUIRED FROM DOGS
Gommeren, Kris ULg; Allerton, Fergus; Morin, Elise et al

in Journal of Veterinary Emergency and Critical Care (in press)

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See detailThe finite index basis property
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Journal of Pure and Applied Algebra (in press)

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See detailAberrations chromatiques : de l’émulsion au pixel
Thonon, Jonathan ULg

in Cahiers Louis Lumière (in press)

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la ... [more ▼]

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la profondeur picturale et de son articulation à la surface : « La nature n'est pas en surface ; elle est en profondeur. Les couleurs sont l'expression, à cette surface, de cette profondeur. Elles montent des racines du monde ». Cet « organisme de couleurs » que constitue le monde est transcrit dans la peinture de Cézanne par une dynamique symbiotique de la couleur et du dessin, de la ligne et du pan. La couleur restitue, par sa masse, son surgissement, son homogénéité, presque sa viscosité, la véritable chaire perceptive du monde ; une vision qui tient à distance la perspective géométrique, photographique, cinématographique fondée sur la transparence et qui repose, comme le signale Merleau-Ponty, sur la « réversibilité des dimensions » (surface-profondeur) et l’entrelacement des choses. C’est cette épaisseur du visible rendu par la couleur que l’économie de l’image numérique nous permet de redécouvrir, moins dans le registre de la « tactilité » de l’image et la picturalité du pixel, que par l’intégration, entre le support et l’image (parfois indiscernables dans le régime optique), d’un « corps » algorithmique qui règle l’actualisation du visible. Certains défauts techniques du dispositif numérique, aujourd’hui élevés au rang de pratique artistique, permettent de révéler cette matrice qui utilise alors la couleur et la coulure comme mode de visibilité. C’est le cas du Datamoshing, technique de composition numérique qui revisite tout en la radicalisant la pratique de l’incrustation vidéo. Basée sur la perturbation volontaire d’éléments de la matrice, cette technique transforme les couleurs en une forme malléable et fluide révélant ainsi leur double nature spatiale : elles sont à la fois dans l’espace de l’image et l’espace de l’image lui-même. Ces expériences de défigurations d’images s’inscrivent dans le registre des « aberrations chromatiques » dont nous proposons ici une rapide généalogie avant d’interroger la couleur digitale dans ses spécificités. [less ▲]

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See detailTime’s Up! Involvement of Metamemory Knowledge, Executive Functions, and Time Monitoring in Children’s Prospective Memory Performance
Geurten, Marie ULg; Lejeune, Caroline ULg; Meulemans, Thierry ULg

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (in press)

This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring ... [more ▼]

This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring strategy depending on the ongoing task’s difficulty. Specifically, a sample of 72 typically developing children aged 4, 6, and 9 years old were given an original PM paradigm composed of both an ongoing procedural activity and a PM task. Half of the participants (expert group) were trained in the ongoing activity before the prospective test. As expected, results show that time monitoring had a positive effect on children’s PM performance. Furthermore, mediation analyses reveal that strategic time monitoring was predicted by metamemory knowledge in the expert group but only by executive functions in the novice group. Overall, these findings provide interesting avenues to explain how metamemory knowledge, strategy use, and executive functions interact to improve PM performance during childhood. [less ▲]

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See detailAn enhanced version of a bone remodelling model based on the continuum damage mechanics theory.
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in Computer Methods in Biomechanics & Biomedical Engineering (2015), 18(12), 1367-1376

The purpose of this work is to propose an enhancement of Doblaré and García's internal bone remodelling model based on the continuum damage mechanics theory. In their paper, they stated that the evolution ... [more ▼]

The purpose of this work is to propose an enhancement of Doblaré and García's internal bone remodelling model based on the continuum damage mechanics theory. In their paper, they stated that the evolution of the internal variables of the bone microstructure, and its incidence on the modification of the elastic constitutive parameters, may be formulated following the principles of Continuum Damage Mechanics, although no actual damage was considered. The resorption and apposition criteria (similar to the damage criterion) were expressed in terms of a mechanical stimulus. However, the resorption criterion is lacking a dimensional consistency with the remodelling rate. We here propose an enhancement to this resorption criterion, insuring the dimensional consistency while retaining the physical properties of the original remodelling model. We then analyse the change in the resorption criterion hypersurface in the stress space for a 2D analysis. We finally apply the new formulation to analyse the structural evolution of a 2D femur. This analysis gives results consistent with the original model but with a faster and more stable convergence rate. [less ▲]

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See detailSemiótica de la acción: textualización y notación
Dondero, Maria Giulia ULg

in Tópicos del seminario (2015), 31

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining ... [more ▼]

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining the forms of enunciative praxis through different levels of pertinence analysis. Secondly, we propose the concept of ‘textualization’ as a mediation between text and action: textualizations (photographs, videos, notes) organize and represent practices which are in themselves ephemeral and elusive. Finally, we will consider the textual diagrammatization that we call ‘notation’: this analytical form of mediation between text and practice does not have the same status of in-vivo textualisations, but it works like an ex-post reconstruction which highlights the main gestures and exchanges while performing their grammaticalization. A more general aim of this essay is an enquiry into the legitimate objects of textual semiotics: what are the objects that it can analyze without betraying its principle of immanence, but also without being confined to it and, as a consequence, being unable to analyze practices and respond to topical questions on social issues and on the research in the human sciences? [less ▲]

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See detailPerformance-Based Aid: Why it will probably not meet promises
Paul, Elisabeth ULg

in Development Policy Review (2015), 33(3),

Performance-based aid (PBA) is increasingly advocated as a way to improve development aid effectiveness through resolving incentive issues inherent in aid relationships. Some donors use PBA together with ... [more ▼]

Performance-based aid (PBA) is increasingly advocated as a way to improve development aid effectiveness through resolving incentive issues inherent in aid relationships. Some donors use PBA together with performance-based financing arrangements within partner countries. Expectations from PBA are high – yet, while its rationale may look appealing, it is grounded on a restrictive model and flawed when taking account of real-world context. A number of problems associated to PBA have already been advanced as jeopardising its success. More fundamentally, one may question the mere appropriateness of PBA to provide incentives all along the chain from recipient governments to those who are supposed to produce results. Thus believing that PBA can have a mechanistic trickle-down incentive effect seems an illusion. [less ▲]

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See detailImpact of Aphasia on Consciousness Assessment: A Cross-Sectional Study.
Schnakers, C; Bessou, H; Rubi-Fessen, I et al

in Neurorehabilitation & Neural Repair (2015), 29

BACKGROUND: . Previous findings suggest that language disorders may occur in severely brain-injured patients and could interfere with behavioral assessments of consciousness. However, no study ... [more ▼]

BACKGROUND: . Previous findings suggest that language disorders may occur in severely brain-injured patients and could interfere with behavioral assessments of consciousness. However, no study investigated to what extent language impairment could affect patients' behavioral responses. OBJECTIVE: . To estimate the impact of receptive and/or productive language impairments on consciousness assessment. METHODS: . Twenty-four acute and subacute stroke patients with different types of aphasia (global, n = 11; Broca, n = 4; Wernicke, n = 3; anomic, n = 4; mixed, n = 2) were recruited in neurology and neurosurgery units as well as in rehabilitation centers. The Coma Recovery Scale-Revised (CRS-R) was administered. RESULTS: . We observed that 25% (6 out of 24) of stroke patients with a diagnosis of aphasia and 54% (6 out of 11) of patients with a diagnosis of global aphasia did not reach the maximal CRS-R total score of 23. An underestimation of the consciousness level was observed in 3 patients with global aphasia who could have been misdiagnosed as being in a minimally conscious state, even in the absence of any documented period of coma. More precisely, lower subscores were observed on the communication, motor, oromotor, and arousal subscales. CONCLUSION: . Consciousness assessment may be complicated by the co-occurrence of severe language deficits. This stresses the importance of developing new tools or identifying items in existing scales, which may allow the detection of language impairment in severely brain-injured patients. [less ▲]

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See detailThe words of prevention, part II: ten terms in the realm of quaternary prevention
Jamoulle, Marc ULg; Gavilan, Enrique; Cardoso, Raquel Val et al

in Revista Brasileira de Medicina de Família e Comunidade (2015)

ABSTRACT Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to ... [more ▼]

ABSTRACT Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to quaternary prevention: (1) overinformation, (2) overdiagnosis, (3) medically unexplained symptoms, (4) overmedicalisation, (5) incidentaloma, (6) overscreening, (7) overtreatment, (8) shared decision making, (9) deprescribing, and (10) disease mongering. Methods: with the support of the laboratory team of the University of Rouen, France, which is dedicated to medical terminology and semantic relationships, it was possible to utilize a graphic user interface (called DBGUI) allowing the construction of links for each of chosen terms, and making automatic links to MeSH, if any. Those concepts are analyzed in their environment in current literature, as well as in their MeSH counterparts, if any, and related semantic online terminologies. Results and Discussion: The rules in terminological development aspire to cover the whole field of a concept and in the meantime, it helps to avoid the noise due to proxy and not exactly related issues. This refers to exhaustivity and specificity in information retrieval. Our finds show that referring to MeSH only in information retrieval in General Practice/Family medicine can induce much noise and poor adequacy to the subject investigated. Conclusion: Gathering concepts in specially prepared terminologies for further development of ontologies is a necessity to enter in the semantic web area and the era of distributed data. [less ▲]

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See detailPrevenção quaternária: primeiro não causar dano - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015)

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See detailAnisotropy and tension-compression asymmetry modeling of the room temperature plastic response of Ti-6A1-4V
Tuninetti, Victor; Gilles, Gaëtan ULg; Pardoen, Thomas et al

in International Journal of Plasticity (2015), 67

The mechanical behavior of the alloy Ti-6A1-4V is characterized using uniaxial tension, uniaxial compression, simple shear and place strain tests in three orthogonal material directions. The experimental ... [more ▼]

The mechanical behavior of the alloy Ti-6A1-4V is characterized using uniaxial tension, uniaxial compression, simple shear and place strain tests in three orthogonal material directions. The experimental results reveal tension/compression asymmetry, anisotropic yielding and anisotropic strain-hardening. These features are incorporated into an elasto-plastic constitutive law based on the macroscopic orthotropic yield criterion "CPB06" adapted to hexagonal metals. A new identification method for the yield criterion parameters is proposed by inverse modeling of the axial strain field compression specimens in the three orthogonal directions of the material. The sensitivity of different sets of material parameters to the identification method is also analysed and the capacity of the model to accurately predict the forces and displacement field is discussed. A validation of the best set of identified CPB06material parameters is performed by comparing the load-displacement curves in different loading directions for tensile tests on notched round bars with different levels of stress triaxiality and for compression tests on elliptical cross-section specimens, both tests involving multiaxial strain fields and large deformations. [less ▲]

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See detailQuaternary prevention: first, do not harm - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015)

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See detailThe words of prevention, part I: changing the model
Jamoulle, Marc ULg; Gavilan, Enrique; Cardoso, Raquel Val et al

in Revista Brasileira de Medicina de Família e Comunidade (2015)

ABSTRACT Objective: This part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain. The aim is to contribute to information ... [more ▼]

ABSTRACT Objective: This part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain. The aim is to contribute to information process in GP/FM by keeping in line with the main terms used in health care organization. Methods: Important keywords for GP/FM in the prevention domain were selected. Then, a search was carried out on the main sources in GP/FM databases, as well as in Medical Subject Heading and major terminological databases available online. Results and Discussion: There is discrepancy between the conceptual contents of major prevention models amongst the usual bibliographic sources of knowledge in GP/FM in particular and medicine in general. Conclusion: For GP/FM, distribution of preventive activities is now firmly established on a new constructivist model, privileging the doctor-patient relationships and introducing a cybernetic thinking on the health care activities with a special commitment to ethics and the positive duty of beneficence. [less ▲]

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See detailBioassessment of trace element contamination of Mediterranean coastal waters using the seagrass Posidonia oceanica
Richir, Jonathan ULg; Salivas-Decaux, Maÿlis; Lafabrie, Céline et al

in Journal of Environmental Management (2015), 150

A large scale survey of the trace element (TE) contamination of Mediterranean coastal waters was performed from the analysis of Ag, As, Cd, Cu, Hg, Ni and Pb in the bioindicator Posidonia oceanica ... [more ▼]

A large scale survey of the trace element (TE) contamination of Mediterranean coastal waters was performed from the analysis of Ag, As, Cd, Cu, Hg, Ni and Pb in the bioindicator Posidonia oceanica, sampled at 110 sites differing by their levels of exposure to contaminants. The holistic approach developed in this study, based on the combined utilization of several complementary monitoring tools, i.e. water quality scale, pollution index and spatial analysis, accurately assessed the TE contamination rate of Mediterranean coastal waters. In particular, the mapping of the TE contamination according to a new proposed 5-level water quality scale precisely outlined the contamination severity along Mediterranean coasts and facilitated interregional comparisons. Finally, the reliability of the use of P. oceanica as bioindicator species was again demonstrated through several global, regional and local detailed case studies. NB: The designations employed and the presentation of the information in thisdocument do not imply the expression of any opinion whatsoever on the part of the authors concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. [less ▲]

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See detailRotation, spectral variability, magnetic geometry and magnetosphere of the Of?p star CPD -28° 2561
Wade, G. A.; Barbá, R. H.; Grunhut, J. et al

in Monthly Notices of the Royal Astronomical Society (2015), 447

We report magnetic and spectroscopic observations and modelling of the Of?p star CPD -28° 2561. Using more than 75 new spectra, we have measured the equivalent width variations and examined the dynamic ... [more ▼]

We report magnetic and spectroscopic observations and modelling of the Of?p star CPD -28° 2561. Using more than 75 new spectra, we have measured the equivalent width variations and examined the dynamic spectra of photospheric and wind-sensitive spectral lines. A period search results in an unambiguous 73.41 d variability period. High-resolution spectropolarimetric data analysed using least-squares deconvolution yield a Zeeman signature detected in the mean Stokes V profile corresponding to phase 0.5 of the spectral ephemeris. Interpreting the 73.41 d period as the stellar rotational period, we have phased the equivalent widths and inferred longitudinal field measurements. The phased magnetic data exhibit a weak sinusoidal variation, with maximum of about 565 G at phase 0.5, and a minimum of about -335 G at phase 0.0, with extrema approximately in phase with the (double-wave) Hα equivalent width variation. Modelling of the Hα equivalent width variation assuming a quasi-3D magnetospheric model produces a unique solution for the ambiguous couplet of inclination and magnetic obliquity angles: (i, β) or (β, i) = (35°, 90°). Adopting either geometry, the longitudinal field variation yields a dipole polar intensity B[SUB]d[/SUB] = 2.6 ± 0.9 kG, consistent with that obtained from direct modelling of the Stokes V profiles. We derive a wind magnetic confinement parameter η[SUB]*[/SUB] ≃ 100, leading to an Alfvén radius R[SUB]A[/SUB] ≃ 3-5R[SUB]*[/SUB], and a Kepler radius R[SUB]K[/SUB] ≃ 20R[SUB]*[/SUB]. This supports a physical scenario in which the Hα emission and other line variability have their origin in an oblique, corotating `dynamical magnetosphere' structure resulting from a magnetically channelled wind. Nevertheless, the details of the formation of spectral lines and their variability within this framework remain generally poorly understood. [less ▲]

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See detailHow well can cold dark matter substructures account for the observed radio flux-ratio anomalies
Xu, Dandan; Sluse, Dominique ULg; Gao, Liang et al

in Monthly Notices of the Royal Astronomical Society (2015), 447

Discrepancies between the observed and model-predicted radio flux ratios are seen in a number of quadruply-lensed quasars. The most favoured interpretation of these anomalies is that cold dark matter (CDM ... [more ▼]

Discrepancies between the observed and model-predicted radio flux ratios are seen in a number of quadruply-lensed quasars. The most favoured interpretation of these anomalies is that cold dark matter (CDM) substructures present in lensing galaxies perturb the lens potentials and alter image magnifications and thus flux ratios. So far no consensus has emerged regarding whether or not the predicted CDM substructure abundance fully accounts for the lensing flux anomaly observations. Accurate modelling relies on a realistic lens sample in terms of both the lens environment and internal structures and substructures. In this paper, we construct samples of generalized and specific lens potentials, to which we add (rescaled) subhalo populations from the galaxy-scale Aquarius and the cluster-scale Phoenix simulation suites. We further investigate the lensing effects from subhaloes of masses several orders of magnitude below the simulation resolution limit. The resulting flux-ratio distributions are compared to the currently best available sample of radio lenses. The observed anomalies in B0128+437, B0712+472 and B1555+375 are more likely to be caused by propagation effects or oversimplified/improper lens modelling, signs of which are already seen in the data. Among the quadruple systems that have closely located image triplets/pairs, the anomalous flux ratios of MG0414+0534 can be reproduced by adding CDM subhaloes to its macroscopic lens potential, with a probability of 5-20 per cent; for B0712+472, B1422+231, B1555+375 and B2045+265, these probabilities are only of a few per cent. We hence find that CDM substructures are unlikely to be the whole reason for radio flux anomalies. We discuss other possible effects that might also be at work. [less ▲]

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See detailThe small binary asteroid (939) Isberga
Carry, B.; Matter, A.; Scheirich, P. et al

in Icarus (2015), 248

In understanding the composition and internal structure of asteroids, their density is perhaps the most diagnostic quantity. We aim here at characterizing the surface composition, mutual orbit, size, mass ... [more ▼]

In understanding the composition and internal structure of asteroids, their density is perhaps the most diagnostic quantity. We aim here at characterizing the surface composition, mutual orbit, size, mass, and density of the small main-belt binary asteroid (939) Isberga. For that, we conduct a suite of multi-technique observations, including optical lightcurves over many epochs, near-infrared spectroscopy, and interferometry in the thermal infrared. We develop a simple geometric model of binary systems to analyze the interferometric data in combination with the results of the lightcurve modeling. From spectroscopy, we classify Ibserga as a Sq-type asteroid, consistent with the albedo of 0.14<SUB>-0.06</SUB><SUP>+0.09</SUP> (all uncertainties are reported as 3-σ range) we determine (average albedo of S-types is 0.197 ± 0.153, see Pravec et al. (Pravec et al. [2012]. Icarus 221, 365-387). Lightcurve analysis reveals that the mutual orbit has a period of 26.6304 ± 0.0001 h, is close to circular (eccentricity lower than 0.1), and has pole coordinates within 7° of (225°, +86°) in Ecliptic J2000, implying a low obliquity of 1.5<SUB>-1.5</SUB><SUP>+6.0</SUP> deg . The combined analysis of lightcurves and interferometric data allows us to determine the dimension of the system and we find volume-equivalent diameters of 12.4<SUB>-1.2</SUB><SUP>+2.5</SUP> km and 3.6<SUB>-0.3</SUB><SUP>+0.7</SUP> km for Isberga and its satellite, circling each other on a 33 km wide orbit. Their density is assumed equal and found to be 2.91<SUB>-2.01</SUB><SUP>+1.72</SUP> gcm<SUP>-3</SUP> , lower than that of the associated ordinary chondrite meteorites, suggesting the presence of some macroporosity, but typical of S-types of the same size range (Carry [2012]. Planet. Space Sci. 73, 98-118). The present study is the first direct measurement of the size of a small main-belt binary. Although the interferometric observations of Isberga are at the edge of MIDI capabilities, the method described here is applicable to others suites of instruments (e.g., LBT, ALMA). [less ▲]

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See detailBuilding on anticipation: dystopia as empowerment
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Current Sociology (2015), 63(2),

A dystopia can be defined as the depiction of a dark future building on the systematic amplification of current trends and features. It relates to a complex narrative posture that relies on the critical ... [more ▼]

A dystopia can be defined as the depiction of a dark future building on the systematic amplification of current trends and features. It relates to a complex narrative posture that relies on the critical observation of a threatening present that would lead to an apocalyptic future “if nothing was done.” Yet, however inescapable this future may be described, the very existence of such a narrative presupposes that the political community it tries to reach is actually able to do something to thwart it. Oddly enough, a successful dystopia aims at making itself obsolete: once the world it depicts is identified as a possible (or even unavoidable) future, it seems to empower its readers again, restoring what Musil called a ‘sense of possibilities’ that eventually make alternative pathways thinkable. In our contribution, we propose to broaden the range of commonly accepted dystopists (usually fiction writers and novelists like e.g. George Orwell’s 1984) to sociologists like Ulrich Beck. Building on his Risk Society (1986), Beck’s strong diagnosis about the breakdown of First Modernity and the coming of Second Modernity contains a noticeable prophetic and evangelical overtone that aims at “reinventing politics.” We defend the notion that the dystopian posture can be used to characterize both fiction and nonfiction writers such as Orwell and Beck: a common ability, based on the same set of inextricably cognitive and normative patterns, to anticipate the future and eventually empower political communities to engage in further action. [less ▲]

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See detailWhat is important in being cured from: Does discordance between physicians and patients matter? (2)
Demyttenaere, Koen; Donneau, Anne-Françoise ULg; Albert, Adelin ULg et al

in Journal of Affective Disorders (2015), 174(2015), 372-377

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See detailRitournelles et territoires professionnels. Le cas des conseillers emploi
Orianne, Jean-François ULg

in Langage et Société (2015), 151

L’objectif de ce texte est d’utiliser le concept de ritournelle pour analyser la formation d’un groupe professionnel dans le champ des politiques d’emploi en Belgique : les conseillers emploi du FOREM ... [more ▼]

L’objectif de ce texte est d’utiliser le concept de ritournelle pour analyser la formation d’un groupe professionnel dans le champ des politiques d’emploi en Belgique : les conseillers emploi du FOREM. L’auteur commence par définir et opérationnaliser le concept, emprunté à Deleuze et Guattari, en suivant les apports des théories de la communication réflexive. Il esquisse brièvement le contexte politique et institutionnel au sein duquel le groupe professionnel apparaît. Ensuite, il analyse trois ritournelles professionnelles, trois procédés de territorialisation des identités professionnelles des conseillers emploi. Il précise, en conclusion, la complémentarité du concept de ritournelle avec celui de rhétorique professionnelle. [less ▲]

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See detailDoes the production of Belgian bioethanol fit with European requirements on GHG emissions? Case of wheat
Belboom, Sandra ULg; Bodson, Bernard ULg; Léonard, Angélique ULg

in Biomass & Bioenergy (2015), 74

This paper undertakes an environmental evaluation of bioethanol production, using wheat cultivated in Belgium. Cultivation steps are modelled using Belgian specific data. Wheat transformation in ethanol ... [more ▼]

This paper undertakes an environmental evaluation of bioethanol production, using wheat cultivated in Belgium. Cultivation steps are modelled using Belgian specific data. Wheat transformation in ethanol relies on industrial data. GHG emissions of the whole life cycle are calculated and compared with the default values given by the European Renewable Energy Directive. Belgian wheat bioethanol achieves a 5% higher GHG reduction than the one mentioned in the European directive but impact repartition is different with a higher importance of cultivation step in our case. Belgian wheat bioethanol complies with the current sustainability criteria but is also able to conform to further ones. Sensitivity analyses are performed on the importance of N fertilizers and associated emissions known as main important parameters. These analyses reveal non negligible variations and then a range of available GHG reduction when using wheat bioethanol. [less ▲]

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See detailWhat is important in being cured from depression? Discordance between physicians and patients (1)
Demyttenaere, Koen; Donneau, Anne-Françoise ULg; Albert, Adelin ULg et al

in Journal of Affective Disorders (2015), 174(2015), 390-396

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See detailBaryon resonances in large Nc QCD
Matagne, Nicolas; Stancu, Floarea ULg

in Reviews of Modern Physics (2015)

We review the current status and present open challenges of large $N_c$ QCD baryon spectroscopy. After introducing the $1/N_c$ expansion method we first shortly revisit the latest achievements for the ... [more ▼]

We review the current status and present open challenges of large $N_c$ QCD baryon spectroscopy. After introducing the $1/N_c$ expansion method we first shortly revisit the latest achievements for the ground state properties. Next we discuss the applicability of this method to excited states, presenting two different approaches with their advantages and disadvantages. Selected results for the spectrum and strong and electromagnetic decays are described. We also present further developments for the applicability of the method to excited states, based on the qualitative compatibility between the quark excitation picture and the meson-nucleon scattering picture. We show that a quantitative comparison between results obtained from the mass formula of the $1/N_c$ expansion method and quark models brings convincing support to quark models and shortly discuss the implications of different large $N_c$ limits. We stress that the SU(6) spin-flavor structure of large $N_c$ baryon allows a convenient classification of highly excited resonances into SU(3) multiplets and predicts mass ranges for the missing partners. [less ▲]

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See detailData in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Hervé et al

in Data in Brief (2015), 2(0), 1-5

2D-DIGE analysis coupled with mass spectrometry is a global, without a priori, comparative proteomic approach particularly suited to identify and quantify enzymes isoforms and structural proteins, thus ... [more ▼]

2D-DIGE analysis coupled with mass spectrometry is a global, without a priori, comparative proteomic approach particularly suited to identify and quantify enzymes isoforms and structural proteins, thus making it an efficient tool for the characterization of the changes in cell phenotypes that occur in physiological and pathological conditions. In this data article in support of the research article entitled “Metabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study” [1] we illustrate the changes in protein profile that occur during the metabolic reprogramming undergone by cultured mouse astrocytes in a model of in-vitro cancerous transformation [2]. [less ▲]

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See detailEconomics of a decision-support system for managing the main fungal diseases of winter wheat in the Grand-Duchy of Luxembourg
El Jarroudi, Moussa ULg; Kouadio, Louis; Beyer, Marco et al

in Field Crops Research (2015), 172(2), 32-41

We evaluated the cost effectiveness of a decision-support system (DSS) developed for assessing in real time the risk of progression of the main fungal diseases (i.e., Septoria leaf blotch, powdery mildew ... [more ▼]

We evaluated the cost effectiveness of a decision-support system (DSS) developed for assessing in real time the risk of progression of the main fungal diseases (i.e., Septoria leaf blotch, powdery mildew, leaf rusts and Fusarium head blight) of winter wheat in the Grand-Duchy of Luxembourg (GDL). The study was conducted in replicated field experiments located in four agricultural locations (representative of the main agro-ecological regions of the country) over a 10-year period (2003-2012). Three fungicide spray strategies were compared: a single DSS-based system and two commonly used spray practices in the GDL, a double- (2T)- and a triple- spray (3T) spray treatment; there was also a non-treated control. In years with a high disease pressure, the DSS-based recommendation resulted in protection of the three upper leaves comparable to that achieved with the 2T and 3T treatments, with significant grain yield increases (P > 0.05) compared to the control (a 4 to 42% increase, depending on the site and year). Overall, the financial gain in treated plots compared with the control ranged from 3 to 16% at the study sites. Furthermore, in seasons when dry weather conditions precluded epidemic development, no the DSS-basedDSS recommended no fungicide spray was recommended, reducing use of fungicide, and thus saving the cost of the product. The gain in yield for the 2T and 3T plots (compared with control) did not necessarily result in a financial gain during the duration of the experiment. This study demonstrates the potential advantages and profitability of using a DSS -based approach for disease management. [less ▲]

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See detailA Review of Pharmaceutical Extrusion: Critical Process Parameters and Scaling-up
Thiry, Justine ULg; Krier, Fabrice ULg; Evrard, Brigitte ULg

in International Journal of Pharmaceutics (2015), 479(1), 227-240

Hot melt extrusion has been a widely used process in the pharmaceutical area for three decades. In this field, it is important to optimize the formulation in order to meet specific requirements. However ... [more ▼]

Hot melt extrusion has been a widely used process in the pharmaceutical area for three decades. In this field, it is important to optimize the formulation in order to meet specific requirements. However, the process parameters of the extruder should be as much investigated as the formulation since they have a major impact on the final product characteristics. Moreover, a design space should be defined in order to obtain the expected product within the defined limits. This gives some freedom to operate as long as the processing parameters stay within the limits of the design space. Those limits can be investigated by varying randomly the process parameters but it is recommended to use design of experiments. An examination of the literature is reported in this review to summarize the impact of the variation of the process parameters on the final product properties. Indeed, the homogeneity of the mixing, the state of the drug (crystalline or amorphous), the dissolution rate, the residence time, can be influenced by variations in the process parameters. In particular, the impact of the following process parameters: temperature, screw design, screw speed and feeding, on the final product, has been reviewed. [less ▲]

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See detailA comparison between visual estimates and image analysis measurements to determine Septoria leaf blotch severity in winter wheat
El Jarroudi, Moussa ULg; Kouadio, Louis; Mackels, Christophe et al

in Plant Pathology (2015)

Methods to estimate disease severity vary in accuracy, reliability, ease of use and cost. Severity of Septoria leaf blotch (SLB, caused by Zymoseptoria graminicola) was estimated by four raters and by ... [more ▼]

Methods to estimate disease severity vary in accuracy, reliability, ease of use and cost. Severity of Septoria leaf blotch (SLB, caused by Zymoseptoria graminicola) was estimated by four raters and by image analysis (assumed actual values) on individual leaves of winter wheat in order to explore accuracy and reliability of estimates, and to ascertain whether there were any general characteristics of error. Specifically, (i) we determined the accuracy and reliability of visual assessments of SLB over the full range of severity from 0 to 100%, and we investigated (ii) whether certain 10% ranges in actual disease severity between 0 and 100% were more prone to estimation error compared with others, and (iii) whether leaf position affected accuracy within those ranges. Lin's concordance correlation analysis of all severities (0 to 100%) demonstrated that all raters had estimates close to the actual values (agreement: ρc = 0.92-0.99). However, agreement between actual SLB severities and estimates by raters was less good when compared over short 10% subdivisions within the 0-100% range (ρc = -0.12 to 0.99). Despite common rater imprecision at estimating low and high SLB severities, individual raters differed considerably in their accuracy over the short 10% subdivisions. There was no effect of leaf position on accuracy or precision of severity estimate on separate leaves (L1-L3). Pursuing efforts in understanding error in disease estimation should aid in improving the accuracy of assessments, making visual estimates of disease severity more useful for research and applied purposes. [less ▲]

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See detailSelf-assembly of a triblock terpolymer mediated by hydrogen-bonded complexes
Guerlain, Claire; Piogé, Sandie; Detrembleur, Christophe ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2015), 53(3), 459-467

A poly(methyl methacrylate)-block-poly(4-vinylpyridine)-block-polystyrene (PMMA-b-P4VP-b-PS) triblock terpolymer is synthesized by ATRP to study its self-assembly with PAA in organic solvents. The self ... [more ▼]

A poly(methyl methacrylate)-block-poly(4-vinylpyridine)-block-polystyrene (PMMA-b-P4VP-b-PS) triblock terpolymer is synthesized by ATRP to study its self-assembly with PAA in organic solvents. The self-assembly behavior of this system is compared with the one of a mixture of two diblocks, namely polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) and poly(methyl methacrylate)-block-poly(methacrylic acid) (PMMA-b-PMAA). For both systems, formation of hydrogen-bonded complexes between the P4VP and PMAA or PAA blocks occurs. These complexes become insoluble in the solvent used and micelles with a P4VP/P(M)AA complexes core surrounded by PS and PMMA coronal chains are obtained in both cases. These micelles are analyzed by DLS and TEM. Spherical micelles are formed for both systems but the hydrodynamic radii obtained for the two types of micelles are different. Indeed, the micelles formed by the PMMA-b-P4VP-b-PS + PAA system are smaller than those observed for the PS-b-P4VP + PMMA-b-PMAA system. Finally, the effect of the molar ratio of the P4VP/PMAA complexing blocks is investigated. [less ▲]

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See detailOn modular decompositions of system signatures
Marichal, Jean-Luc; Mathonet, Pierre ULg

in Journal of Multivariate Analysis (2015), 134

Considering a semicoherent system made up of $n$ components having i.i.d. continuous lifetimes, Samaniego defined its structural signature as the $n$-tuple whose $k$-th coordinate is the probability that ... [more ▼]

Considering a semicoherent system made up of $n$ components having i.i.d. continuous lifetimes, Samaniego defined its structural signature as the $n$-tuple whose $k$-th coordinate is the probability that the $k$-th component failure causes the system to fail. This $n$-tuple, which depends only on the structure of the system and not on the distribution of the component lifetimes, is a very useful tool in the theoretical analysis of coherent systems. It was shown in two independent recent papers how the structural signature of a system partitioned into two disjoint modules can be computed from the signatures of these modules. In this work we consider the general case of a system partitioned into an arbitrary number of disjoint modules organized in an arbitrary way and we provide a general formula for the signature of the system in terms of the signatures of the modules. The concept of signature was recently extended to the general case of semicoherent systems whose components may have dependent lifetimes. The same definition for the $n$-tuple gives rise to the probability signature, which may depend on both the structure of the system and the probability distribution of the component lifetimes. In this general setting, we show how under a natural condition on the distribution of the lifetimes, the probability signature of the system can be expressed in terms of the probability signatures of the modules. We finally discuss a few situations where this condition holds in the non-i.i.d. and nonexchangeable cases and provide some applications of the main results. [less ▲]

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See detailEffects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis
Preud'Homme, Valérie; Milla, Sylvain; Gillardin, Virginie et al

in Chemosphere (2015), 120(2), 357-364

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of ... [more ▼]

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of its wide use and known effects, particularly neurotoxic, on a variety of organisms. However, the effect of endosulfan was not yet evaluated on amphibians at levels encompassing simultaneously brain neurotransmitters and behavioural endpoints. In this context, tadpoles of the African clawed frog Xenopus laevis were submitted to four treatments during 27 d: one control, one ethanol control, and two low environmental concentrations of endosulfan (0.1 and 1 μg L−1). Endosulfan induced a significant increase of brain serotonin level at both concentrations and a significant increase of brain dopamine and GABA levels at the lower exposure but acetylcholinesterase activity was not modified by the treatment. The gene coding for the GABA transporter 1 was up-regulated in endosulfan contaminated tadpoles while the expression of other genes coding for the neurotransmitter receptors or for the enzymes involved in their metabolic pathways was not significantly modified by endosulfan exposure. Endosulfan also affected foraging, and locomotion in links with the results of the physiological assays, but no effects were seen on growth. These results show that low environmental concentrations of endosulfan can induce adverse responses in X. laevis tadpoles. At a broader perspective, this suggests that more research using and linking multiple markers should be used to understand the complex mode of action of pollutants. [less ▲]

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See detailLe dosage de la vitamine D: considérations pré-analytiques et analytiques
LE GOFF, Caroline ULg; Souberbielle, Jean-Claude; Delvin, Edgard et al

in Annales de Biologie Clinique (2015), 73(1), 79-92

The constantly increasing requests for the measurement of serum 25-hydroxyvitamin D over the last years has led reagent manufacturers to market different automated and semi-automated methods, that being ... [more ▼]

The constantly increasing requests for the measurement of serum 25-hydroxyvitamin D over the last years has led reagent manufacturers to market different automated and semi-automated methods, that being unfortunately not fully harmonized, yield different results. Liquid chromatography coupled to tandem mass spectrometry has more recently been introduced. This approach allows the distinction between the two forms of 25-hydroxyvitamin D and to measure other metabolites. This approach also requires harmonization to curtail the differences between the different analytical methods. To meet this requirement, the American national institutes of health (NIH), the CDC (Center for disease control and prevention) in Atlanta, the NIST (National institute of standards and technology) and the vitamin D Reference laboratory of Ghent University have pooled their expertise to develop a standardization program. This article reviews the main elements and the difficulties of the automated and semi-automated methods for 25-hydroxyvitamin D, from sample preparation to the analytical phase, as well as those related to mass spectrometry. It also addresses the issues related to the clinical decision thresholds and the possibility of measurements in different biological liquids. [less ▲]

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See detailNonlinear generalization of Den Hartog׳s equal-peak method
Habib, Giuseppe ULg; Detroux, Thibaut ULg; Viguié, Régis et al

in Mechanical Systems & Signal Processing (2015), 52-53

This study addresses the mitigation of a nonlinear resonance of a mechanical system. In view of the narrow bandwidth of the classical linear tuned vibration absorber, a nonlinear absorber, termed the ... [more ▼]

This study addresses the mitigation of a nonlinear resonance of a mechanical system. In view of the narrow bandwidth of the classical linear tuned vibration absorber, a nonlinear absorber, termed the nonlinear tuned vibration absorber (NLTVA), is introduced in this paper. An unconventional aspect of the NLTVA is that the mathematical form of its restoring force is tailored according to the nonlinear restoring force of the primary system. The NLTVA parameters are then determined using a nonlinear generalization of Den Hartog׳s equal-peak method. The mitigation of the resonant vibrations of a Duffing oscillator is considered to illustrate the proposed developments. [less ▲]

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See detailApplication of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines
Mbinze, Kingenge; Nsangu Mpasi, Jean; Maghe, Elza et al

in American Journal of Analytical Chemistry (2015), 6

In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric ... [more ▼]

In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2-10µg/mL (for quinine sulfate in tablet), 4-12µg/mL (for quinine bichlorhydrate in oral drop - metronidazole benzaote in oral suspension) and 15-35µg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms. [less ▲]

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See detailFighting Poor Quality Medicines: Develop-ment, Transfer and Validation of Generic HPLC Methods for Analyzing two WHO Recommended Antimalarial Tablets
Mbinze Kindenge, Jérémie; Yemoa, Achille; Lebrun, Pierre ULg et al

in American Journal of Analytical Chemistry (2015), 6

As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative ... [more ▼]

As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative techniques. In this study, a generic liquid chromatographic method was firstly devel-oped for the purpose of screening 8 antimalarial active ingredients, namely amodiaquine (AQ), piperaquine (PPQ), sulfalene (SL), pyrimethamine (PM), lumefantrine (LF), artesunate (AS), artemether (AM) and dihydroartemisinine (DHA) by applying DoE/DS optimization strategy. Since the method was not totally satisfying in terms of peak separation, further experiments were undergone applying the same development strategy while splitting the 8 ingredients into five groups. Excellent prediction was observed prior to correlation between retention times of predicted and observed separation conditions. Then, a successful geometric transfer was realized to reduce the analysis time focusing on the simultaneous quantification of two WHO's recommended ACTs in anti-malarial fixed-dose combination (AM-LF and AS-AQ) in tablets. The optimal separation was achieved using an isocratic elution of methanol-ammonium formate buffer (pH 2.8; 10mM) (82.5: 17.5, v/v) at 0.6ml/min through a C18 column (100mm×3.5mm, 3.5 μm) thermostated at 25°C. After a successful validation stage based on the total error approach, the method was applied to determine the content of AM/LF or AS/AQ in seven brands of antimalarial tablets currently marketed in West, Central and East Africa. Satisfying results were obtained compared to the claimed contents. [less ▲]

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See detailPurinergic control of inflammation and thrombosis: Role of P2X1 receptors
Oury, Cécile ULg; LECUT, Christelle ULg; Hego, Alexandre ULg et al

in Computational and Structural Biotechnology Journal (2015), 13

Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Upon tissue damage or infection, a sudden increase of extracellular ATP occurs, that might contribute to the crosstalk between ... [more ▼]

Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Upon tissue damage or infection, a sudden increase of extracellular ATP occurs, that might contribute to the crosstalk between inflammation and thrombosis. On platelets, P2X1 receptors act to amplify platelet activation and aggregation induced by other platelet agonists. These receptors critically contribute to thrombus stability in small arteries. Besides platelets, studies by our group indicate that these receptors are expressed by neutrophils. They promote neutrophil chemotaxis, both in vitro and in vivo. In a laser-induced injury mouse model of thrombosis, it appears that neutrophils are required to initiate thrombus formation and coagulation activation on inflamed arteriolar endothelia. In thismodel, by using P2X1−/−mice,we recently showed that P2X1 receptors, expressed on platelets and neutrophils, play a key role in thrombus growth and fibrin generation. Intriguingly, in a model of endotoxemia, P2X1−/−mice exhibited aggravated oxidative tissue damage, along with exacerbated thrombocytopenia and increased activation of coagulation, which translated into higher susceptibility to septic shock. Thus, besides its ability to recruit neutrophils and platelets on inflamed endothelia, the P2X1 receptor also contributes to limit the activation of circulating neutrophils under systemic inflammatory conditions. Taken together, these data suggest that P2X1 receptors are involved in the interplay between platelets, neutrophils and thrombosis. We propose that activation of these receptors by ATP on neutrophils and platelets represents a new mechanism that regulates thrombo-inflammation. [less ▲]

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See detailLow molecular weight poly (2-dimethylamino ethylmethacrylate) polymers with controlled positioned fluorescent labeling: Synthesis, characterization and in vitro interaction with human endothelial cells.
Flebus, Luca ULg; Lombart, François ULg; Sevrin, Chantal et al

in International journal of pharmaceutics (2015), 478(1), 278-287

Poly (2-dimethylamino ethylmethacrylate) (PDMAEMA) is an attractive non-degradable polymer studied as nonviral vector for gene delivery but it can be also adopted for delivery of other biopharmaceutical ... [more ▼]

Poly (2-dimethylamino ethylmethacrylate) (PDMAEMA) is an attractive non-degradable polymer studied as nonviral vector for gene delivery but it can be also adopted for delivery of other biopharmaceutical drugs. As a parenteral carrier, the PDMAEMA free form (FF) might interact with tissues and cells. Few data are available on its selective internalization and efflux from cells, while the majority of studies published have followed the distribution of DNA complexed with PDMAEMA. In order to address polycation safety, the first aim was to synthesize by atom transfer radical polymerisation (ATRP) fluorescent labeled PDMAEMA of low molecular weight (Mw) (below 15kDa), controlling the position and density of fluorescein. The second goal was to analyze the possible difference in uptake and subcellular distribution of this labeled FF polycation between human umbilical vein endothelial cells (HUVEC) and hCMEC/D3 cells. These two cell lines have been chosen in order to detect selectivity towards the blood-brain barrier (BBB). In both cases, polycation was detected along the plasma membrane followed by progressive migration to the peri-nuclear region, where it overlapped with lysosomal structures. The analysis by fluorescence-activated cell sorting (FACS) of the PDMAEMA uptake by hCMEC/D3 cells showed a significant (p<0.05) inhibition (40%) in presence of 2-dexoxy-d-glucose inhibitor, a result supporting an energy-dependence mechanism(s). Cytotoxicity study showed that low Mw PDMAEMA (10kDa) lead to a minor cytotoxicity compared to the higher ones. As main conclusion this study highlights the similitude in cell trafficking of FF PDMAEMA and data previously reported for PDMAEMA/DNA complexes. [less ▲]

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See detailSymmetry breaking patterns in 3HDM
Ivanov, Igor ULg; Nishi, Celso

in Journal of High Energy Physics [=JHEP] (2015), 15

An attractive feature of New Physics models with multiple Higgs fields is that they are equipped with discrete symmetry groups in the Higgs and flavour sectors. These symmetry groups are often broken at ... [more ▼]

An attractive feature of New Physics models with multiple Higgs fields is that they are equipped with discrete symmetry groups in the Higgs and flavour sectors. These symmetry groups are often broken at the global minimum of the Higgs potential, either completely or to a proper subgroup, with certain phenomenological consequences. Here, we systematically explore these symmetry breaking patterns in the scalar sector of the three-Higgs-doublet model (3HDM). We use the full list of discrete symmetry groups allowed in 3HDM, and for each group we find all possible ways it can break by the Higgs vacuum expectation value alignment. We also discuss the interplay between these symmetry groups and various forms of CP-violation in the scalar sector of 3HDM. Not only do our results solve the problem for 3HDM, but they also hint at several general features in multi-scalar sectors. [less ▲]

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See detailRecent summer Arctic atmospheric circulation anomalies in a historical perspective
Belleflamme, Alexandre ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

in Cryosphere (The) (2015), 9

A significant increase in the summertime occurrence of a high pressure area over the Beaufort Sea, the Canadian Arctic Archipelago, and Greenland has been observed since the beginning of the 2000s, and ... [more ▼]

A significant increase in the summertime occurrence of a high pressure area over the Beaufort Sea, the Canadian Arctic Archipelago, and Greenland has been observed since the beginning of the 2000s, and particularly between 2007 and 2012. These circulation anomalies are likely partly responsible for the enhanced Greenland ice sheet melt as well as the Arctic sea ice loss observed since 2007. Therefore, it is interesting to analyse whether similar conditions might have happened since the late 19th century over the Arctic region. We have used an atmospheric circulation type classification based on daily mean sea level pressure and 500 hPa geopotential height data from five reanalysis data sets (ERA-Interim, ERA-40, NCEP/NCAR, ERA-20C, and 20CRv2) to put the recent circulation anomalies in perspective with the atmospheric circulation variability since 1871. We found that circulation conditions similar to 2007–2012 have occurred in the past, despite a higher uncertainty of the reconstructed circulation before 1940. For example, only ERA-20C shows circulation anomalies that could explain the 1920–1930 summertime Greenland warming, in contrast to 20CRv2. While the recent anomalies exceed by a factor of 2 the interannual variability of the atmospheric circulation of the Arctic region, their origin (natural variability or global warming) remains debatable. [less ▲]

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See detailHigh-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Goyette, Philippe; Boucher, Gabrielle; Mallon, D et al

in Nature Genetics (2015)

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major ... [more ▼]

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD. [less ▲]

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See detailAssociation of Cerebrospinal Fluid Prion Protein Levels and the Distinction Between Alzheimer Disease and Creutzfeldt-Jakob Disease
Dorey, Aline; Tholance, Yannick; Vighetto, Alain et al

in JAMA Neurology (2015)

IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological ... [more ▼]

IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological diagnostic biomarker for identifying CJD, 14-3-3 protein in cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting a rapid dementia presentation. OBJECTIVE To assess the relevance of total CSF prion protein (t-PrP) levels in the differential biological diagnosis between atypical AD phenotypes and CJD. DESIGN, SETTING, AND PARTICIPANTS A retrospective study in an autopsy-confirmed cohort of 82 patients was performed to evaluate the relevance of CSF t-PrP to distinguish 30 definite cases of AD from 52 definite cases of CJD. Next, CSF t-PrP concentration was measured in a cohort of 104 patients including 55 patients with probable AD, 26 with probable sporadic CJD, and 23 control patients for whom 14-3-3 protein, total tau, phosphorylated tau 181 (P-tau181), and Aβ1-42 were available.We investigated 46 patients diagnosed as having probable AD who presented atypical phenotypes. A diagnosis strategy was proposed to classify atypical AD phenotypes with suspicion of CJD based on a decision tree combining CSF biomarkers. MAIN OUTCOMES AND MEASURES We determined CSF t-PrP levels for all patients.We calculated the ratio of total tau and P-tau181 and determined the diagnostic accuracy of each biomarker alone or in combination.We calculated the misclassification rate for each biomarker that corresponded to the percentage of patients within the group of atypical AD phenotypes wrongly classified as CJD. RESULTS In patients with CJD, CSF t-PrP concentrations were decreased compared with control participants and patients with AD. When considering the differential diagnosis of CJD compared with atypical AD phenotypes, CSF t-PrP determination reached 82.1%sensitivity and 91.3%specificity. The misclassification rate of atypical AD phenotypes decreased from 43.5%, obtained when using the CSF 14-3-3 protein determination alone, to only 4.3%when calculating the ratio total tau/(P-tau181 × t-PrP). The proposed classification tree permitted correct classification of 98.4%of the patients. CONCLUSIONS AND RELEVANCE For unusual phenotypes of AD, especially cases presenting with a biological ambiguity suggesting CJD, determination of CSF t-PrP levels increased diagnostic accuracy. The use of CSF t-PrP levels may be beneficial in clinical practice in [less ▲]

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See detailUpscaling of an electronic nose for continuously stirred tank reactor stability monitoring from pilot-scale to real-scale agricultural co-digestion biogas plant
Adam, Gilles ULg; Lemaigre, Sébastien; Goux, Xavier et al

in Bioresource Technology (2015), 178

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to ... [more ▼]

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, volatile fatty acids concentration and to other gas phase compounds. Multivariate statistical process control method, based on principal component analysis and the Hotelling's T² statistics was used to derive an indicator representative of the reactor state. At the pilot-scale level, the e-nose indicator was relevant and could distinguish 3 process states: steady-state, transient and collapsing process. At the full-scale level, the e-nose indicator could provide the warning of the major disturbance whereas two slight disturbances were not detected and it gave one major false alarm. This work showed that gas phase relation with anaerobic process should be deeper investigated, as an e-nose could indicate the reactor state, focusing on the gas phase. [less ▲]

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See detailFeature issue of digital holography and 3D imaging (DH): introduction
Hayasaki, Yoshio; Liu, Jung-Ping; Georges, Marc ULg

in Applied Optics (2015), 54(1), 1-2

The OSA Topical Meeting “Digital Holography and 3D Imaging (DH)” was held in Seattle, Washington, 13–17 July 2014. Feature issues based on the DH meeting series have been released by Applied Optics (AO ... [more ▼]

The OSA Topical Meeting “Digital Holography and 3D Imaging (DH)” was held in Seattle, Washington, 13–17 July 2014. Feature issues based on the DH meeting series have been released by Applied Optics (AO) since 2007. In this year (2014), Optics Express (OE) and AO jointly decided to have one such feature issue in each journal. The feature issue includes 27 papers and covers a large range of topics, reflecting the rapidly expanding techniques and applications of digital holography and 3D imaging. The DH meeting will continue in the future, as expected, and the next meeting is scheduled to be held on24–28 May 2015, at Shanghai Institute of Optics and Fine Mechanics, Shanghai, China. [less ▲]

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See detailCan the collapse of a fly ash heap develop into an air-fluidized flow? - Reanalysis of the Jupille accident (1961)
Stilmant, Frédéric ULg; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Geomorphology (2015), 228

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of ... [more ▼]

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of fluidization attracted scientific attention. As drillings and direct observations revealed no water-saturated zone at the base of the deposits, scientists assumed an air-fluidization mechanism, which appeared consistent with the properties of the material. In this paper, the air-fluidization assumption is tested based on two-dimensional numerical simulations. The numerical model has been developed so as to focus on the most prominent processes governing the flow, with parameters constrained by their physical interpretation. Results are compared to accurate field observations and are presented for different stages in the model enhancement, so as to provide a base for a discussion of the relative influence of pore pressure dissipation and pore pressure generation. These results show that the apparently high diffusion coefficient that characterizes the dissipation of air pore pressures is in fact sufficiently low for an important degree of fluidization to be maintained during a flow of hundreds of meters. [less ▲]

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See detailThe binary near-Earth Asteroid (175706) 1996 FG3 - An observational constraint on its orbital evolution
Scheirich, P.; Pravec, P.; Jacobson, S. A. et al

in Icarus (2015), 245

Using our photometric observations taken between April 1996 and January 2013 and other published data, we derived properties of the binary near-Earth Asteroid (175706) 1996 FG<SUB>3</SUB> including new ... [more ▼]

Using our photometric observations taken between April 1996 and January 2013 and other published data, we derived properties of the binary near-Earth Asteroid (175706) 1996 FG<SUB>3</SUB> including new measurements constraining evolution of the mutual orbit with potential consequences for the entire binary asteroid population. We also refined previously determined values of parameters of both components, making 1996 FG<SUB>3</SUB> one of the most well understood binary asteroid systems. With our 17-year long dataset, we determined the orbital vector with a substantially greater accuracy than before and we also placed constraints on a stability of the orbit. Specifically, the ecliptic longitude and latitude of the orbital pole are 266 ° and - 83 ° , respectively, with the mean radius of the uncertainty area of 4 ° , and the orbital period is 16.1508 ± 0.0002 h (all quoted uncertainties correspond to 3σ). We looked for a quadratic drift of the mean anomaly of the satellite and obtained a value of 0.04 ± 0.20 deg /yr<SUP>2</SUP> , i.e., consistent with zero. The drift is substantially lower than predicted by the pure binary YORP (BYORP) theory of McMahon and Scheeres (McMahon, J., Scheeres, D. [2010]. Icarus 209, 494-509) and it is consistent with the tigidity and quality factor of μQ = 1.3 ×10<SUP>7</SUP> Pa using the theory that assumes an elastic response of the asteroid material to the tidal forces. This very low value indicates that the primary of 1996 FG<SUB>3</SUB> is a 'rubble pile', and it also calls for a re-thinking of the tidal energy dissipation in close asteroid binary systems. [less ▲]

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See detailV444 Cygni X-ray and polarimetric variability: Radiative and Coriolis forces shape the wind collision region
Lomax, J. R.; Nazé, Yaël ULg; Hoffman, J. L. et al

in Astronomy and Astrophysics (2015), 573

We present results from a study of the eclipsing, colliding-wind binary V444 Cyg that uses a combination of X-ray and optical spectropolarimetric methods to describe the 3D nature of the shock and wind ... [more ▼]

We present results from a study of the eclipsing, colliding-wind binary V444 Cyg that uses a combination of X-ray and optical spectropolarimetric methods to describe the 3D nature of the shock and wind structure within the system. We have created the most complete X-ray light curve of V444 Cyg to date using 40 ks of new data from Swift, and 200 ks of new and archived XMM-Newton observations. In addition, we have characterized the intrinsic, polarimetric phase-dependent behavior of the strongest optical emission lines using data obtained with the University of Wisconsin's Half-Wave Spectropolarimeter. We have detected evidence of the Coriolis distortion of the wind-wind collision in the X-ray regime, which manifests itself through asymmetric behavior around the eclipses in the system's X-ray light curves. The large opening angle of the X-ray emitting region, as well as its location (i.e. the WN wind does not collide with the O star, but rather its wind) are evidence of radiative braking/inhibition occurring within the system. Additionally, the polarimetric results show evidence of the cavity the wind-wind collision region carves out of the Wolf-Rayet star's wind. [less ▲]

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See detailThe Gaia-ESO Survey: CNO abundances in the open clusters Trumpler 20, NGC 4815, and NGC 6705
Tautvaišienė, G.; Drazdauskas, A.; Mikolaitis, Š. et al

in Astronomy and Astrophysics (2015), 573

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. <BR /> Aims: We aim ... [more ▼]

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. <BR /> Aims: We aim to determine C, N, and O abundances in stars of Galactic open clusters of the Gaia-ESO survey and to compare the observed abundances with those predicted by current stellar and Galactic evolution models. In this pilot paper, we investigate the first three intermediate-age open clusters. <BR /> Methods: High-resolution spectra, observed with the FLAMES-UVES spectrograph on the ESO VLT, were analysed using a differential model atmosphere method. Abundances of carbon were derived using the C[SUB]2[/SUB] band heads at 5135 and 5635.5 Å. The wavelength interval 6470-6490 Å, with CN features, was analysed to determine nitrogen abundances. Oxygen abundances were determined from the [O i] line at 6300 Å. <BR /> Results: The mean values of the elemental abundances in Trumpler 20 as determined from 42 stars are: [ Fe/H ] = 0.10 ± 0.08 (s.d.), [ C/H ] = -0.10 ± 0.07, [ N/H ] = 0.50 ± 0.07, and consequently C/N = 0.98 ± 0.12. We measure from five giants in NGC 4815: [ Fe/H ] = -0.01 ± 0.04, [ C/H ] = -0.17 ± 0.08, [ N/H ] = 0.53 ± 0.07, [ O/H ] = 0.12 ± 0.09, and C/N = 0.79 ± 0.08. We obtain from 27 giants in NGC 6705: [ Fe/H ] = 0.0 ± 0.05, [ C/H ] = -0.08 ± 0.06, [ N/H ] = 0.61 ± 0.07, [ O/H ] = 0.13 ± 0.05, and C/N = 0.83 ± 0.19. The C/N ratios of stars in the investigated open clusters were compared with the ratios predicted by stellar evolutionary models. For the corresponding stellar turn-off masses from 1.9 to 3.3 M[SUB]⊙[/SUB], the observed C/N ratio values are very close to the predictions of standard first dredge-up models as well as to models of thermohaline extra-mixing. They are not decreased as much as predicted by the recent model in which the thermohaline- and rotation-induced extra-mixing act together. The average [O/H] abundance ratios of NGC 4815 and NGC 6705 are compared with the predictions of two Galactic chemical evolution models. The data are consistent with the evolution at the solar radius within the errors. <BR /> Conclusions: The first results of CNO determinations in open clusters show the potential of the Gaia-ESO Survey to judge stellar and Galactic chemical evolution models and the validity of their physical assumptions through a homogeneous and detailed spectral analysis. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002 (The Gaia-ESO Public Spectroscopic Survey, PIs G. Gilmore and S. Randich). [less ▲]

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See detailDust from Comet 209P/LINEAR during its 2014 Return: Parent Body of a New Meteor Shower, the May Camelopardalids
Ishiguro, Masateru; Kuroda, Daisuke; Hanayama, Hidekazu et al

in The Astrophysical Journal Letters (2015), 798

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was ... [more ▼]

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was apparently inactive at a heliocentric distance r<SUB>h</SUB> = 1.6 AU and showed weak activity at r<SUB>h</SUB> <= 1.4 AU. We found an active region of <0.001% of the entire nuclear surface during the comet's dormant phase. An edge-on image suggests that particles up to 1 cm in size (with an uncertainty of factor 3-5) were ejected following a differential power-law size distribution with index q = –3.25 ± 0.10. We derived a mass-loss rate of 2-10 kg s<SUP>–1</SUP> during the active phase and a total mass of ≈5 × 10<SUP>7</SUP> kg during the 2014 return. The ejection terminal velocity of millimeter- to centimeter-sized particles was 1-4 m s<SUP>–1</SUP>, which is comparable to the escape velocity from the nucleus (1.4 m s<SUP>–1</SUP>). These results imply that such large meteoric particles marginally escaped from the highly dormant comet nucleus via the gas drag force only within a few months of the perihelion passage. [less ▲]

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See detailForbidden oxygen lines at various nucleocentric distances in comets
Decock, Alice ULg; Jehin, Emmanuel ULg; Rousselot, P. et al

in Astronomy and Astrophysics (2015), 573

Aims: We study the formation of the [OI] lines - that is, 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the two red lines) - in the coma of comets and determine the parent species of the oxygen ... [more ▼]

Aims: We study the formation of the [OI] lines - that is, 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the two red lines) - in the coma of comets and determine the parent species of the oxygen atoms using the ratio of the green-to-red-doublet emission intensity, I[SUB]5577[/SUB]/(I[SUB]6300[/SUB] + I[SUB]6364[/SUB]), (hereafter the G/R ratio) and the line velocity widths. <BR /> Methods: We acquired high-resolution spectroscopic observations at the ESO Very Large Telescope of comets C/2002 T7 (LINEAR), 73P-C/Schwassmann-Wachmann 3, 8P/Tuttle, and 103P/Hartley 2 when they were close to Earth (<0.6 au). Using the observed spectra, which have a high spatial resolution (<60 km/pixel), we determined the intensities and widths of the three [OI] lines. We spatially extracted the spectra to achieve the best possible resolution of about 1-2'', that is, nucleocentric projected distances of 100 to 400 km depending on the geocentric distance of the comet. We decontaminated the [OI] green line from C[SUB]2[/SUB] lines blends that we identified. <BR /> Results: The observed G/R ratio in all four comets varies as a function of nucleocentric projected distance (between ~0.25 to ~0.05 within 1000 km). This is mainly due to the collisional quenching of O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) by water molecules in the inner coma. The observed green emission line width is about 2.5 km s[SUP]-1[/SUP] and decreases as the distance from the nucleus increases, which can be explained by the varying contribution of CO[SUB]2[/SUB] to the O([SUP]1[/SUP]S) production in the innermost coma. The photodissociation of CO[SUB]2[/SUB] molecules seem to produce O([SUP]1[/SUP]S) closer to the nucleus, while the water molecule forms all the O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) atoms beyond 10[SUP]3[/SUP] km. Thus we conclude that the main parent species producing O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) in the inner coma is not always the same. The observations have been interpreted in the framework of the previously described coupled-chemistry-emission model, and the upper limits of the relative abundances of CO[SUB]2[/SUB] were derived from the observed G/R ratios. Measuring the [OI] lines might provide a new way to determine the CO[SUB]2[/SUB] relative abundance in comets. Based on observations made with ESO Telescope at the La Silla Paranal Observatory under programs ID 073.C-0525, 277.C-5016, 080.C-0615 and 086.C-0958.Tables 3 and 4 are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424403/olm">http://www.aanda.org</A> [less ▲]

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See detailBasin-scale partitioning of Greenland ice sheet mass balance components (2007–2011)
Andersen, M.L.; Stenseng, L.; Skourup, H. et al

in Earth and Planetary Science Letters (2015), 409

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be ... [more ▼]

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be well captured by observationally-constrained climate modeling, insight into D is relatively limited. We use InSAR-derived velocities, in combination with ice thickness observations, to quantify the mass flux (F ) across a flux perimeter around the ice sheet at ∼1700 m elevation. To quantify D , we correct F for SMB , as well as changes in volume due to ice dynamics, in the area downstream of the gate. Using a 1961–1990 reference climatology SMB field from the MAR regional climate model, we quantify ice sheet mass balance within eighteen basins. We find a 2007–2011 mean D of View the MathML source. We find a 2007–2011 mean total mass balance of View the MathML source, which is equal to a 0.73 mm yr−1 global sea level rise contribution. This mass loss is dominated by SMB, which accounts for 61% of mass loss in the basins where partitioning is possible. [less ▲]

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See detailMonte Carlo Simulation of Metastable Oxygen Photochemistry in Cometary Atmospheres
Bisikalo, D. V.; Shematovich, V. I.; Gérard, Jean-Claude ULg et al

in The Astrophysical Journal (2015), 798

Cometary atmospheres are produced by the outgassing of material, mainly H[SUB]2[/SUB]O, CO, and CO[SUB]2[/SUB] from the nucleus of the comet under the energy input from the Sun. Subsequent photochemical ... [more ▼]

Cometary atmospheres are produced by the outgassing of material, mainly H[SUB]2[/SUB]O, CO, and CO[SUB]2[/SUB] from the nucleus of the comet under the energy input from the Sun. Subsequent photochemical processes lead to the production of other species generally absent from the nucleus, such as OH. Although all comets are different, they all have a highly rarefied atmosphere, which is an ideal environment for nonthermal photochemical processes to take place and influence the detailed state of the atmosphere. We develop a Monte Carlo model of the coma photochemistry. We compute the energy distribution functions (EDF) of the metastable O([SUP]1[/SUP]D) and O([SUP]1[/SUP]S) species and obtain the red (630 nm) and green (557.7 nm) spectral line shapes of the full coma, consistent with the computed EDFs and the expansion velocity. We show that both species have a severely non-Maxwellian EDF, that results in broad spectral lines and the suprathermal broadening dominates due to the expansion motion. We apply our model to the atmosphere of comet C/1996 B2 (Hyakutake) and 103P/Hartley 2. The computed width of the green line, expressed in terms of speed, is lower than that of the red line. This result is comparable to previous theoretical analyses, but in disagreement with observations. We explain that the spectral line shape does not only depend on the exothermicity of the photochemical production mechanisms, but also on thermalization, due to elastic collisions, reducing the width of the emission line coming from the O([SUP]1[/SUP]D) level, which has a longer lifetime. [less ▲]

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See detailStimuli-responsive behavior of micelles prepared from a poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer
Poggi, Elio; Guerlain, Claire; Debuigne, Antoine ULg et al

in European Polymer Journal (2015), 62

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4 ... [more ▼]

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4-vinylpyridine) precursor (PVAc-b-PAN-b-P4VP) synthesized by a combination of cobalt-mediated radical polymerization (CMRP) and nitroxide mediated polymerization (NMP). The PVOH-b-PAA-b-P4VP terpolymer is further micellized in water and the accordingly obtained micellar structures are characterized by a combination of dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM) as a function of pH. Well-defined micelles are observed in the whole pH range except for pH values below 4.5 where non-aggregated chains (unimers) are present. The formation of micelles can be rationalized by the formation of insoluble PAA/P4VP inter-polyelectrolyte complexes in the 4.5–6 pH range while hydrophobic P4VP cores are observed at pH values above 6. Finally, the effect of the addition of different salts on the micellar characteristic features is investigated. [less ▲]

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See detailGuaranteed Conditional Performance of the S2 Control Chart with Estimated Parameters
Faraz, Alireza ULg; Heuchenne, Cédric ULg; Woodall, William

in International Journal of Production Research (2015)

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to ... [more ▼]

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to have confidence that the in-control average run length (ARL) obtained will be near the desired value. To overcome this problem, we adjust the S2 chart controls limits such that the in-control ARL is guaranteed to be above a specified value with a certain specified probability. The required adjustment does not have too much of an effect on the out-of-control performance of the chart. [less ▲]

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See detailRhoGTPases as Key players in mammalian cell adaptation to microgravity.
Louis, Fiona; Deroanne, Christophe ULg; Nusgens-Richelle, Betty ULg et al

in BioMed Research International (2015)

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See detailVascular calcification: from pathophysiology to biomarkers
EVRARD, Séverine ULg; DELANAYE, Pierre ULg; Kamel, S et al

in Clinica Chimica Acta (2015), 438

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have ... [more ▼]

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlightedmore and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtedly identified as predisposing factors. But even if the process is better understood,many questions still remain unanswered. This reviewbriefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, the main purpose of the article is to provide a profile of the various existing biomarkers of VC. Indeed, in the past years, a lot of inhibitors and promoters, which form a dense and interconnected network, were identified. Given importance to assess and control mineralization process, a focusing on accumulated knowledge of each marker seemed to be necessary. Therefore, we tried to define their respective role in the physiopathology and how they can contribute to calcification risk assessment. Among these, Klotho/fibroblast growth factor-23, fetuin-A, Matrix Gla protein, Bone morphogenetic protein-2, osteoprotegerin, osteopontin, osteonectin, osteocalcin, pyrophosphate and sclerostin are specifically discussed. [less ▲]

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See detailCompte-rendu de l'ouvrage d'Eva Illouz : "Hard Romance : "Cinquante nuances de Grey" et nous" (2014)
Ledent, David ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2015)

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See detailLa France et le Congo ex-belge (1961-1965). Intérêts et influences en mutation
Genin, Vincent ULg

in Revue Belge de Philologie et d'Histoire (2015), 91(2013/4), 1057-1110

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective ... [more ▼]

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective. Ostracized by the United Nations in the summer of 1960 in the context of the Congolese crisis, Belgium has, however, been able to count on the support of France, itself immobilized by the Algerian case. Based on unpublished archives, it seems instructive to study the evolution of the Franco-Belgian relations, in terms of Central African Affairs from 1961 to 1965. France, the overseas influence policy is a fundamental factor, she will devote as much energy to develop and defend its interests in Congo former Belgian (on which she claimed in Brussels its preemptive right, dating back to 1884, spring 1960) as former territories of the French Community? What are the forms, the protagonists and channels (formal and informal) of this influence; how is she fits the postcolonial context and she has an impact on Franco-Belgian relations ? [less ▲]

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See detailIn situ bidentate to tetradentate ligand exchange reaction in cobalt-mediated radical polymerization
Kermagoret, Anthony ULg; Jérôme, Christine ULg; Detrembleur, Christophe ULg et al

in European Polymer Journal (2015), 62

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this ... [more ▼]

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this, none of the reported complexes offers optimal control for monomers with very different reactivity, which somewhat limits the synthesis of copolymers. In order to expand the scope of cobalt-mediated radical polymerization (CMRP), we investigated an in situ ligand exchange reaction for modulating the properties of the cobalt complex at the polymer chain-end and adjusting the C-Co bond strength involved in the control process. With the aim of improving the synthesis of poly(vinyl acetate)-b-poly(n-butyl acrylate) copolymers, bidentate acetylacetonate ligands, which impart high level of control to the polymerization of vinyl acetate (VAc), were replaced in situ at the PVAc-cobalt chain-end by tetradentate Salen type ligands that are more suited to acrylates. [less ▲]

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See detailN1-Fluoroalkyltryptophan analogues: synthesis and in vitro study as potential substrates for indoleamine 2,3-dioxygenase
Henrottin, Jean ULg; Zervosen, Astrid ULg; Lemaire, Christian ULg et al

in ACS Medicinal Chemistry Letters (2015)

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive ... [more ▼]

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive properties in inflammatory and tumoral tissues. The syntheses of 1-(2-fluoroethyl)-tryptophan (1-FETrp) and 1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-tryptophan, two N1-fluoroalkylated tryptophan derivatives, are described here. In vitro enzymatic assays with these two new potential substrates of hIDO show that 1-FETrp is a good and specific substrate of hIDO. Therefore, its radioactive isotopomer, 1-[18F]FETrp, should be a molecule of choice to visualize tumoral and inflammatory tissues and/or to validate new potential inhibitors. [less ▲]

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See detailSEM and EDS observations of carrollite bioleaching with a mixed culture of acidophilic bacteria
Nkulu, Guy; Gaydardzhiev, Stoyan ULg; Mwema, Edouard et al

in Minerals Engineering (2015), doi:10.1016/j.mineng.2014.12.005

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to ... [more ▼]

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to provide evidence of the interaction pattern between carrollite and microorganisms. A bacterial consortium involving three different acidophilic chemolithotrophs was adopted. The evolution of the surface topography, inside alteration effects and elemental composition of the mineral with leaching time was followed. It could be postulated that bacterial adhesion takes place on the mineral surface, resulting in the formation of dissolution pits of various shapes and continues by boring elongated channels deep inside the mineral grains. Enhanced concentration of ferric iron and sulphur could be assumed in vicinity of the zones where mineralized polymer substances are precipitated. It could be inferred that carrollite dissolution is governed by cooperative bioleaching involving oxidation induced by bacteria attached to the surface and ferric iron re-oxidized by planktonic bacteria in suspension. [less ▲]

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See detailMetabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study.
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Herve et al

in Journal of proteomics (2015), 113

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for ... [more ▼]

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for nucleotide, protein and lipid synthesis necessary for macromolecule assembly and tumor growth. We applied a 2D-DIGE (Two-Dimensional Differential in-Gel Electrophoresis) quantitative proteomic analysis to characterize the proteomes of mouse astrocytes that underwent in vitro cancerous transformation, and of their normal counterparts. Metabolic reprogramming effects on enzymatic and structural protein expression as well as associated metabolites abundance were quantified. Using enzymatic activity measurements and zymography, we documented and confirmed several changes in abundance and activity of various isoenzymes likely to participate in metabolic reprogramming. We found that after transformation, the cells increase their expression of glycolytic enzymes, thus augmenting their ability to use aerobic glycolysis (Warburg effect). An increased capacity to dispose of reducing equivalents through lactate production was also documented. Major effects on carbohydrates, amino acids and nucleotides metabolic enzymes were also observed. Conversely, the transformed cells reduced their enzymatic capacity for reactions of tricarboxylic acid oxidation, for neurotransmitter (glutamate) metabolism, for oxidative stress defense and their expression of astroglial markers. BIOLOGICAL SIGNIFICANCE: The use of a global approach based on a 2D DIGE analysis allows obtaining a comprehensive view of the metabolic reprogramming undergone by astrocytes upon cancerous transformation. Indeed, except for a few enzymes such as pyruvate carboxylase and glutaminase that were not detected in our initial analysis, pertinent information on the abundance of most enzymes belonging to pathways relevant to metabolic reprogramming was directly obtained. In this in vitro model, transformation causes major losses of astrocyte-specific proteins and functions and the acquisition of metabolic adaptations that favor intermediate metabolites production for increased macromolecule biosynthesis. Thus our approach appears to be readily applicable for the investigation of changes in protein abundance that determine various transformed cell phenotypes. It could similarly be applied to the evaluation of the effects of treatments aimed at correcting the consequences of cell transformation. [less ▲]

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See detailMultiscale modelling framework for the fracture of thin brittle polycrystalline films - Application to polysilicon
Mulay, Shantanu; Becker, Gauthier ULg; Vayrette, Renaud et al

in Computational Mechanics (2015), 55(1), 73-91

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability ... [more ▼]

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability. The effect of the orientation of grains on the fracture behaviour of polycrystalline silicon is investigated out of the several factors. This is achieved, firstly, by identifying the statistical variation of the fracture strength and critical strain energy release rate, at the nanoscopic scale, over a thin freestanding polycrystalline silicon film, having mesoscopic scale dimensions. The fracture stress and strain at the mesoscopic level are found to be closely matching with uniaxial tension experimental results. Secondly, the polycrystalline silicon film is considered at the continuum MEMS scale, and its fracture behaviour is studied by incorporating the nanoscopic scale effect of grain orientation. The entire modelling and simulation of the thin film is achieved by combining the discontinuous Galerkin method and extrinsic cohesive law describing the fracture process. [less ▲]

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See detailPossibilities for Co(III) dissolution from an oxidized ore through simultaneous bioleaching of pyrite
Zeka, Leon; Lambert, Fanny ULg; Frenay, Jean ULg et al

in Minerals Engineering (2015)

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and ... [more ▼]

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and abiotic experiments at various pulp densities and redox potentials have been performed and results compared. Cobalt leaching at elevated redox potential is possible, offering cost reduction benefits due to reduced consumption of ferrous iron. At elevated potential of 625 mV, however, the initial rate of cobalt leaching has been found as 115 mg/(g ore)⋅(24 h), lower than the rate of 865 mg/(g ore)⋅(24 h) registered at 505 mV. Less stochiometric amount of ferrous iron was required when cobalt leaching was coupled to pyrite bioleaching, with 75% of cobalt recovered for 12 h at the optimally found conditions. It could be inferred that the Fe3+–Fe2+ cycle exists and is efficiently maintained through bacterial presence in the studied system. [less ▲]

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See detailLes médias contre la mémoire?
Devresse, Jenifer ULg; Grandjean, Geoffrey ULg

in Cahiers Mémoire et Politique (2015), 2

Introduction au numéro "Médias en jeu, enjeux de mémoires" des Cahiers Mémoire et Politique. Au coeur de nos sociétés dites « hypermédiatisées », les médias se sont imposés comme le lieu par excellence où ... [more ▼]

Introduction au numéro "Médias en jeu, enjeux de mémoires" des Cahiers Mémoire et Politique. Au coeur de nos sociétés dites « hypermédiatisées », les médias se sont imposés comme le lieu par excellence où se diffusent et se construisent les perceptions, les représentations et les imaginaires qui forment et informent les rapports entre social et politique. Or, s’ils engagent le devenir des sociétés, ces rapports interrogent fondamentalement la relation au passé, inlassablement reconstruit pour dessiner le présent. Médias et mémoires ont ainsi partie liée, quitte à reconnaître que celle-ci soit marquée au sceau du manque ou du paradoxe. La perspective adoptée suit quelques-uns des nombreux fils qui tissent leurs rapports, s'attachant à analyser le rôle des médias (qu'il s'agisse de médias de masse ou de médias à diffusion plus restreinte); ce qu’ils « font » à la mémoire, à ses régimes de (re)production et de diffusion. Le numéro interroge également les dimensions politiques de ces rapports; qu’il s’agisse des politiques renvoyant aux actions et décisions adoptées par des autorités politiques ; de la politique entendue comme rapports de force entre les acteurs ; ou du politique concernant plus largement les règles du « vivre ensemble ». En particulier, « Médias en jeu, enjeux de mémoires » s’articule autour de deux axes: le premier s’attache à l’analyse des logiques médiatiques de production et de reproduction de la mémoire, et tend à mettre en évidence les règles qui président à la construction d’un consensus mémoriel; le second axe est consacré quant à lui aux logiques de transformation – celles qui font émerger de nouvelles voix ou qui font évoluer les modalités d’appréhension d’une mémoire – et éclaire davantage les dynamiques de concurrence mémorielle. [less ▲]

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