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See detailLate Pleistocene molecular dating of past population fragmentation and demographic changes in African rain forest tree species supports the forest refuge hypothesis
Duminil, Jérôme; Mona, Stefano; Mardulyn, Patrick et al

in Journal of Biogeography (in press)

Aim : Phylogeographical signatures of past population fragmentation and demographic change have been reported in several African rain forest trees. These signatures have usually been interpreted in the ... [more ▼]

Aim : Phylogeographical signatures of past population fragmentation and demographic change have been reported in several African rain forest trees. These signatures have usually been interpreted in the light of the Pleistocene forest refuge hypothesis, although dating these events has remained impracticable because of inadequate genetic markers. We assess the timing of interspecific and intraspecific genetic differentiation and demographic changes within two rain forest Erythrophleum tree species (Fabaceae: Caesalpinioideae). Location : Tropical forests of Upper Guinea (West Africa) and Lower Guinea (Atlantic Central Africa). Methods : Six single-copy nuclear genes were used to characterize the phylogeographical patterns of the parapatric sister species Erythrophleum suaveolens (characteristic of semi-deciduous or gallery forests) and Erythrophleum ivorense (characteristic of evergreen forests). The number of gene pools within each species was determined and the timings of their divergence and past demographic changes were estimated using Bayesian-based coalescent approaches. Results : Three geographically separated gene pools were identified within E. suaveolens, and a single gene pool was inferred in E. ivorense. All gene pools show signatures of demographic bottlenecks concomitant with the last glacial period (c. 120–12 ka). Species-tree inferences show that the two species diverged c. 600 ka, whereas the divergence between E. suaveolens gene pools was dated to the late Pleistocene (first divergence c. 120 ka, second c. 60 ka). Main conclusions : (1) Molecular dating of demographic changes of two African tropical forest tree species is consistent with the Pleistocene forest refuge hypothesis. (2) Tree species from Guinean evergreen tropical forests might have been less affected by past climate change than semi-deciduous species. (3) Our phylogeographical data support a recent date (Holocene) of the last opening of the Dahomey Gap. [less ▲]

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See detailCommercial farming of Leiolepis guttata (Cuvier, 1829) in Binh Thuan province, Vietnam: implications for conservation and management
Rochette, Anne-Julie; Tran, Tinh ULg; De Martynoff, Abigail et al

in Herpetological Conservation and Biology (in press), 10(1),

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See detailImmune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation following Flu-TBI versus TLI-ATG Conditioning
HANNON, Muriel ULg; BEGUIN, Yves ULg; Ehx, Grégory ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (in press)

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft ... [more ▼]

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft-versus-tumor effects without graft-versus-host disease (GVHD). Experimental Design: We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n=28) or 8 Gy TLI plus anti-thymocyte globulin (TLI arm, n=25). Results: In comparison to TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P=0.02), a higher incidence of CMV reactivation (P<0.001), and a higher incidence of relapse (P=0.01). While recovery of total CD8+ T cells was similar in the two groups, with median CD8+ T cell counts reaching the normal values 40-60 days after allo-HCT, TLI patients had lower percentages of naïve CD8 T cells. Median CD4+ T cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Further, CD4+ T cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, while median absolute regulatory T cell (Treg) counts were comparable in TBI and TLI patients, Treg/naïve CD4+ T cell ratios were significantly higher in TLI than in TBI patients the 2 first years after transplantation. Conclusions: Immune recovery differs substantially between these two conditioning regimens possibly explaining the different clinical outcomes observed (NCT00603954). [less ▲]

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See detailSérialités tintamarresques. Du faux-feuilleton au dictionnaire
Saint-Amand, Denis ULg

in Belphégor : Littérature Populaire et Culture Médiatique (in press)

Parmi les journaux comiques les plus en vue du XIXe siècle, l’hebdomadaire Tintamarre occupe une place de choix. Ses fers de lance, Jean-Louis Commerson et Eugène Vachette s’adjoignent les services ... [more ▼]

Parmi les journaux comiques les plus en vue du XIXe siècle, l’hebdomadaire Tintamarre occupe une place de choix. Ses fers de lance, Jean-Louis Commerson et Eugène Vachette s’adjoignent les services imaginaires de l’écrivain de papier Joseph Citrouillard, qui va rapidement se révéler l’un des contributeurs les plus fidèles du Tintamarre et le sujet de nombreux articles. C’est, dès lors, une double logique sérielle qui se développe autour de Citrouillard, à la fois canular auctorial et antihéros populaire. Cet article interroge les implications et les effets de cette double casquette fantaisiste en ce qui concerne la logique interne du journal et le développement en son sein d’une poétique parodique spécifique, mais également en matière d’institutionnalisation d’une forme de mystification littéraire. [less ▲]

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See detailLes Fumistes wallons, un collectif en figuration
Saint-Amand, Denis ULg

in Textyles : Revue des Lettres Belges de Langue Française (in press)

Cet article propose l’analyse d’un cas particulier et très peu étudié de mise en scène de la vie collective en se fondant sur le texte à clef Les Fumistes wallons signé L. Hemma (pseudonyme d’Albert ... [more ▼]

Cet article propose l’analyse d’un cas particulier et très peu étudié de mise en scène de la vie collective en se fondant sur le texte à clef Les Fumistes wallons signé L. Hemma (pseudonyme d’Albert Mockel). On y montre comment, en tant qu’entrée en littérature, le texte de Mockel se donne à voir comme un positionnement singulier vis-à-vis de l’espace littéraire, dont l’auteur aborde d’emblée le fonctionnement en le raillant. [less ▲]

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See detailDefining multiplication in some additive expansions of polynomial rings
Point, Françoise; Rigo, Michel ULg; Waxweiler, Laurent

in Communications in Algebra (in press)

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this ... [more ▼]

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this applies to polynomial rings over a finite field. [less ▲]

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See detailDe Rome à Wilderen : Alexandre Ier et Raoul de Saint-Trond
Schmidt, Kevin ULg

in Revue Belge de Philologie et d'Histoire (in press)

While Rudolf, the abbot of Sint-Truiden (1108-1138) was forced to abandon his monastery in 1121 after having opposed the claim to power of the future prince-bishop of Liège, Alexandre I (1128-1135), both ... [more ▼]

While Rudolf, the abbot of Sint-Truiden (1108-1138) was forced to abandon his monastery in 1121 after having opposed the claim to power of the future prince-bishop of Liège, Alexandre I (1128-1135), both men hastily set out for Rome on the eve of 1129, in order to meet Pope Honorius the Second. The Gesta abbatum Trudonensium have preserved this colorful account of the perilous circumstances under which they crossed the Great St. Bernard Pass together in full winter. Starting from this particular anecdote, the document, which recounts the evolving personal relationship between the bishop of Liège, Alexandre I and abbot Rudolf of Sint-Truiden, returns to the circumstances surrounding this surprising rapprochement, which came to pass against all expectations. It seeks to demonstrate that Rudolf of Sint-Truiden’s motivations to accompany his former enemy to Italy were political rather than spiritual. [less ▲]

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See detailNGOs and female circumcision in Egypt. An anthropological enquiry.
Mescoli, Elsa ULg

in Journal of the Anthropology of the Contemporary Middle East and Central Eurasia (in press)

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the ... [more ▼]

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the circumcision of a ten-year-old child living in this very same city. Discourses around female circumcision were not new in Egypt and in the international community, but what was considered as a new episode of a recurrent scandal (not the last one indeed) led to enhance the "war against bad government"[1]. A war fought by means of ideological weapons produced by expert knowledges among which the medical and the feminist ones. The assignment of a value to the state of integrity of the female body and to the women freedom of choice, both designed according to Western canons, led to different actions to “save” Egyptian women. In this context, development agencies fosters a widespread representation of the victim, constituted by the woman mutilated body. Such representation is functional to put in place programs which do not guarantee a freedom of choice, but rather require adherence to another female model, one that defines the "modern" woman. My article, based on ethnographic experience, aims at highlighting the complexity of such dynamics and the role played by humanitarianism within them. Female body becomes the arena where local and international economic powers operate, disregarding a real understanding of the practice, its meanings and its eventual change. ________________________________________ [1] Foucault, Michel. La nascita della clinica. Il ruolo della medicina nella costituzione delle scienze umane, Einaudi, Torino 1969: 48. [less ▲]

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See detailOut of Himalaya: the impact of past Asian environmental changes on the evolutionary and biogeographical history of Dipodoidea (Rodentia)
Pisano, Julie ULg; Condamine, Fabien L.; Lebedev, Vladimir et al

in Journal of Biogeography (in press)

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See detailLa question du diagnostic en psychiatrie infanto-juvénile
de Becker, Emmanuel; François, Anne; Kinoo, Philippe et al

in Psychiatrie de l'Enfant (La) (in press)

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi ... [more ▼]

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi que les multiples échanges entre professionnels concernés. Le diagnostic pédopsychiatrique est un processus dynamique, modifiable et momentané, les organisations pathologiques étant pour la plupart en transformation permanente. De manière spécifique et en fonction du processus développemental, la thématique du diagnostic en pédopsychiatrie renvoie plus à la question du risque évolutif qu’à la question d’un état pathologique en soi. Les aspects de la continuité des troubles mentaux de l’enfance à l’âge adulte représentent en effet un véritable enjeu développemental. Deux points de vue s’opposent dans la littérature. Le premier, en lien avec un prédéterminisme, estime que les trajectoires sont toutes tracées, l’incertitude reposant dans le diagnostic ; concrètement, il s’agit de repérer de manière précoce des individus à risque parce qu’ils sont porteurs d’un trouble qu’il faut traiter. Le second point de vue considère que les trajectoires ne sont pas déterminées mais sont en réécriture permanente ; ici, le risque ne se situe plus au niveau du diagnostic mais du pronostic, dans un souci de prévention et non de prédiction. L’article propose les réflexions de quatre cliniciens psychiatres infanto-juvéniles sur cette thématique, à la lumière de leur pratique et de leurs échanges. [less ▲]

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See detailOccurrence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary, Argentina, and their mid-distance movements along the Northeast Patagonian coast
Failla, Mauricio; Seijas, Veronica; Vermeulen, Els ULg

in Latin American Journal of Aquatic Mammals (in press)

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data ... [more ▼]

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data on the dolphin’s activity patterns were gathered via an Ad Libitum focal group sampling mode accompanying dorsal fin images taken for identification and re-identification of individuals. A total effort of 188 h resulted in 58 h of positive observation of 124 dolphin groups (sightings per unit effort (SPUE) = 0.66 groups/h). Data analysis showed two main activity states for the observed groups, travelling (65%) and foraging (26%). The remaining 9% of the groups were involved in other activity states. The photo-identification effort, which started opportunistically in 2006, resulted in a catalogue of 21 individual dolphins, with a total mean re-identification rate of 9 days (max = 24 days). When comparing these pictures to the existing catalogue of Bahía San Antonio (approximately 200 km west from the study area) dorsal fins of 20 individuals could be positively matched and most (n = 17) could be subsequently re-identified in both areas, indicating their long distance movements along the North Patagonian coast during the austral autumn months. This season coincides with the lowest amount of feeding activity observed in Bahía San Antonio. This study suggests that bottlenose dolphins enter RNE, mainly during autumn, to forage. It appears that the search for food resources may be the trigger for their movement patterns along the North Patagonian coast during this season, at least for certain individuals. More research is needed to accurately confirm this hypothesis. [less ▲]

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See detailL’utilisation du facteur de Bayes pour identifier les étudiants qui répondent au hasard
Béland, Sébastien; Raîche, Gilles; Magis, David ULg

in Revue des Sciences de l'Education (in press)

Les méthodes permettant de détecter les réponses au hasard dans l’évaluation des apprentissages présentent quelques limites. Par exemple, les indices de détection de patrons de réponses inappropriés ... [more ▼]

Les méthodes permettant de détecter les réponses au hasard dans l’évaluation des apprentissages présentent quelques limites. Par exemple, les indices de détection de patrons de réponses inappropriés (person-fit indexes) nécessitent généralement de grandes bases de données et permettent seulement de dire si un étudiant répond en accord ou non avec un modèle de mesure (par exemple, le modèle de Rasch). Dans le cadre de cet article, nous présentons une nouvelle approche permettant d’identifier les étudiants qui répondent au hasard lors d'épreuves d'évaluation des apprentissages. Après avoir discuté des limites des principales approches existantes, nous exposons les détails techniques de l'utilisation du facteur de Bayes pour évaluer un nombre fini d'hypothèses informatives. Ensuite, nous appliquons le facteur de Bayes à des données simulées et des données réelles obtenues à des fins d’illustration. Les résultats permettent de voir que le facteur de Bayes est une méthode prometteuse pour détecter le comportement de réponse au hasard. [less ▲]

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See detailRisques d'inégalités liés à certaines caractéristiques des manuels contemporains de langues modernes
Simons, Germain ULg; Delbrassine, Daniel ULg; Van Hoof, Florence ULg

in Recherche en Education (2016), 25

Cet article épingle huit caractéristiques de trois manuels de langues contemporains (anglais, allemand, espagnol), qui présentent des risques d'inégalités pour les apprenants. Chacune des caractéristiques ... [more ▼]

Cet article épingle huit caractéristiques de trois manuels de langues contemporains (anglais, allemand, espagnol), qui présentent des risques d'inégalités pour les apprenants. Chacune des caractéristiques est illustrée par des exemples issus des trois manuels. [less ▲]

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See detailLarge predatory marine reptiles from the Albian–Cenomanian of Annopol, Poland
Bardet, Nathalie; Fischer, Valentin ULg; Machalski, Marcin

in Geological Magazine (2016)

During the Early–Late Cretaceous transition, marine ecosystems in Eurasia hosted a diverse set of large predatory reptiles that occupied various niches. However, most of our current knowledge of these ... [more ▼]

During the Early–Late Cretaceous transition, marine ecosystems in Eurasia hosted a diverse set of large predatory reptiles that occupied various niches. However, most of our current knowledge of these animals is restricted to a small number of bonebed-like deposits. Little is known of the geographical and temporal extent of such associations. The middle Albian – middle Cenomanian phosphorite-bearing succession exposed at Annopol, Poland produces numerous ichthyosaurian and plesiosaurian fossils. These are mostly isolated skeletal elements (e.g. teeth, vertebrae), but disarticulated partial skeletons and an articulated, sub vertically embedded ichthyosaur skull are also available. The following taxa are identified: ‘Platypterygius’ sp., cf. Ophthalmosaurinae, Ichthyosauria indet., Polyptychodon interruptus, Pliosauridae indet., Elasmosauridae<indet. and Plesiosauria indet. The large-sized ichthyosaur ‘Platypterygius’ and the pliosaurid Polyptychodon interruptus predominate within the upper Albian – middle Cenomanian deposits. The Annopol record, combined with data from England, France and western Russia, suggests that ‘Platypterygius’ and Polyptychodon interruptus formed a long-term, stable ecological sympatry in marine ecosystems of the European archipelago, at least during the Albian – middle Cenomanian. In addition, the marine reptile assemblage from Annopol is distinct from other Eurasian ecosystems in containing also elasmosaurids in its Albian portion. [less ▲]

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See detailReview of Véronique Maisier’s Violence in Caribbean Literature: Stories of Stones and Blood
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2016), 90(3&4),

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See detailReassessment of the acrylamide risk: Belgium as a case-study
Claes, Wendie; De Meulenaer, Bruno; Huyghebaert, André et al

in Food Control (2016), 59

Acrylamide is a food process contaminant with carcinogenic and genotoxic properties. As a result of intensive research, numerous mitigation initiatives to prevent its formation were suggested and various ... [more ▼]

Acrylamide is a food process contaminant with carcinogenic and genotoxic properties. As a result of intensive research, numerous mitigation initiatives to prevent its formation were suggested and various of them were implemented in the food chain. To evaluate if the mitigation strategies applied were significant, a comparison was made between two time periods (2002e2007 versus 2008e2013) in terms of acrylamide food levels and dietary exposure in Belgian. The most important changes observed are a significant decrease of the acrylamide content in potato crisps and gingerbread, and a significant increase in (instant) coffee. Additionally, the acrylamide content of breakfast cereals, bread and rolls, chocolate and baby biscuits showed a downward trend, whereas for coffee substitute and ready-to-eat French fries (mainly obtained from catering facilities), an upward, although not significant, trend was observed. These changes resulted in only a slight, but insignificant decline of the overall dietary exposure of adults, adolescents and children. The mean and P95 intake estimated in the 2008e2013 period for these consumer groups corresponded to margins of exposure (MOE) ranging between 515 and 236 and between 155 and 71, respectively, when based on the endpoint for neoplastic effects (BMDL10 ¼ 0.17 mg/kg bw per day). Such low MOE values indicate that acrylamide remains an issue for public concern, requiring renewed attention. [less ▲]

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See detailProvenance of Ichthyosaura alpestris (Caudata: Salamandridae) introductions to France and New Zealand assessed by mitochondrial DNA analysis
Arntzen, Jan W.; King, Tania M.; Denoël, Mathieu ULg et al

in The Herpetological Journal (2016), 26

The last century has seen an unparalleled movement of species around the planet as a direct result of human activity, which has been a major contributor to the biodiversity crisis. Amphibians represent a ... [more ▼]

The last century has seen an unparalleled movement of species around the planet as a direct result of human activity, which has been a major contributor to the biodiversity crisis. Amphibians represent a particularly vulnerable group, exacerbated by the devastating effects of chytrid fungi. We report the malicious translocation and establishment of the alpine newt (Ichthyosaura alpestris) to its virtual antipode in North Island of New Zealand. We use network analysis of mitochondrial DNA haplotypes to identify the original source population as I. a. apuana from Tuscany, Italy. Additionally, a population in southern France, presumed to be introduced, is identified as I. a. alpestris from western Europe. However, the presence of two differentiated haplotypes suggests a mixed origin. This type of analysis is made possible by the recent availability of a phylogenetic analysis of the species throughout its natural range. We discuss the particulars of both introductions. [less ▲]

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See detailBrentano, la théorie des catégories et la définition de la substance
Boccaccini, Federico ULg

in Etudes Philosophiques (2016)

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See detailPressure-impulse diagram of a beam under developing non-linear membrane action under
Hamra, Lotfi ULg; Demonceau, Jean-François ULg; Denoël, Vincent ULg

in International Journal of Impact Engineering (2016)

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See detailA probabilistic model for predicting the uncertainties of the humid stiction phenomenon on hard materials
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Journal of Computational & Applied Mathematics (2015), 289

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the ... [more ▼]

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the surfaces roughness and the adhesive force range, the real contact areas are usually smaller than the apparent one, resulting in a scatter in the adhesive forces. Consequently, the stiction is an uncertain phenomenon. In this work, we develop a probabilistic model to predict the uncertainties of stiction due to the capillary forces acting on stiff materials. This model contains two levels: at the deterministic level, the model can predict the pull-out adhesive contact forces for a given surface topology; at the probabilistic level, the model generates independent identically distributed surfaces on which the deterministic solution can be applied to evaluate the uncertainties related to the stiction phenomenon. [less ▲]

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See detailDevelopment and validation of a short Italian UPPS-P Impulsive Behavior Scale
D'Orta, Isabella; Burnay, Jonathan ULg; Aiello, Daniela et al

in Addictive Behaviors Reports (2015), 2

Impulsivity is a multidimensional construct that plays a prominent role in the development, maintenance, and relapse of addictive disorders. The UPPS-P model of impulsivity, which distinguishes between ... [more ▼]

Impulsivity is a multidimensional construct that plays a prominent role in the development, maintenance, and relapse of addictive disorders. The UPPS-P model of impulsivity, which distinguishes between five impulsivity components (positive urgency, negative urgency, lack of perseverance, lack of premeditation, sensation seeking), has been increasingly investigated during the last decade in relation to addictive and risky behaviors. Unfortunately, it currently lacks a validated scale that allows Italian researchers and clinicians to measure impulsivity based on the UPPS-P model. The current study fills this gap by testing the psychometric properties of a short 20-item Italian scale used to assess the five dimensions of the UPPS-P model in 188 volunteer participants from the community. Confirmatory factor analysis supported a model of five distinct, but interrelated, impulsivity components. The results indicated good internal consistency (Cronbach's α ranges from .73 to .84). Construct validity was evidenced by specific relations with measures of addictive behaviors and depressive symptoms. On the whole, this study demonstrated that the Italian short UPPS-P has good psychometric properties. [less ▲]

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See detailDevelopment and validation of a short Italian UPPS-P Impulsive Behavior Scale
D'Orta, Isabella; Burnay, Jonathan ULg; Aiello, Daniela et al

in Addictive Behaviors Reports (2015), 2

Impulsivity is a multidimensional construct that plays a prominent role in the development, maintenance, and relapse of addictive disorders. The UPPS-P model of impulsivity, which distinguishes between ... [more ▼]

Impulsivity is a multidimensional construct that plays a prominent role in the development, maintenance, and relapse of addictive disorders. The UPPS-P model of impulsivity, which distinguishes between five impulsivity components (positive urgency, negative urgency, lack of perseverance, lack of premeditation, sensation seeking), has been increasingly investigated during the last decade in relation to addictive and risky behaviors. Unfortunately, it currently lacks a validated scale that allows Italian researchers and clinicians to measure impulsivity based on the UPPS-P model. The current study fills this gap by testing the psychometric properties of a short 20-item Italian scale used to assess the five dimensions of the UPPS-P model in 188 volunteer participants from the community. Confirmatory factor analysis supported a model of five distinct, but interrelated, impulsivity components. The results indicated good internal consistency (Cronbach's α ranges from .73 to .84). Construct validity was evidenced by specific relations with measures of addictive behaviors and depressive symptoms. On the whole, this study demonstrated that the Italian short UPPS-P has good psychometric properties. [less ▲]

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See detailTentative insight into the multiplicity of the persistent dust maker WR 106 from X-ray observations
De Becker, Michaël ULg

in New Astronomy (2015), 41

This paper presents the results of the analysis of the very first dedicated X-ray observation with XMM-Newton of WR 106. This carbon-rich WC9d Wolf–Rayet star belongs to the category of persistent dust ... [more ▼]

This paper presents the results of the analysis of the very first dedicated X-ray observation with XMM-Newton of WR 106. This carbon-rich WC9d Wolf–Rayet star belongs to the category of persistent dust makers (WCd stars). The issue of the multiplicity of these dust makers is pivotal to understand the dust formation process, and in this context X-ray observations may allow to reveal an X-ray emission attributable to colliding-winds in a binary system. The main result of this analysis is the lack of detection of X-rays coming from WR 106. Upper limits on the X-ray flux are estimated, but the derived numbers are not sufficient to provide compelling constraints on the existence or not of a colliding-wind region. Detailed inspection of archive data bases reveals that persistent dust makers have been poorly investigated by the most sensitive X-ray observatories. Certainly, the combination of several approaches to indirectly constrain their multiplicity should be applied to lift a part of the veil on the nature of these persistent dust makers. [less ▲]

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See detailAvant-propos
Cormann, Grégory ULg; Hamers, Jérémy ULg; Letawe, Céline ULg

in Cahiers d'Etudes Germaniques (2015)

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See detailLe pouvoir des sentiments : Kluge, Adorno, Ferenczi
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Cahiers d'Etudes Germaniques (2015)

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See detailA Parallel Processing Approach to Dynamic Simulations of Combined Transmission and Distribution Systems
Aristidou, Petros ULg; Van Cutsem, Thierry ULg

in International Journal of Electrical Power & Energy Systems (2015), 72

Simulating a power system with both transmission and distribution networks modeled in detail is a huge computational challenge. In this paper, a Schur-complement-based domain decomposition algorithm is ... [more ▼]

Simulating a power system with both transmission and distribution networks modeled in detail is a huge computational challenge. In this paper, a Schur-complement-based domain decomposition algorithm is proposed to provide accurate, detailed dynamic simulations of such systems. The simulation procedure is accelerated with the use of parallel programming techniques, taking advantage of the parallelization opportunities inherent to domain decomposition algorithms. The proposed algorithm is general, portable and scalable on inexpensive, shared-memory, multi-core machines. A large-scale test system is used for its performance evaluation. [less ▲]

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See detailDerivation and Application of Sensitivities to Assess Transient Voltage Sags caused by Rotor Swings
Weckesser, Tilman; Johannsson, Hjortur; Ostergaard, Jacob et al

in International Journal of Electrical Power & Energy Systems (2015), 72

The paper introduces an approach to investigate voltage sags, which are caused by large generator rotor swings following a transient disturbance. Therefore, the method exploits sensitivities derived from ... [more ▼]

The paper introduces an approach to investigate voltage sags, which are caused by large generator rotor swings following a transient disturbance. Therefore, the method exploits sensitivities derived from the algebraic network equations. These provide information on the impact of a generator on the voltage magnitude at a load bus and the e ffect of load variation on the generator's power injection. It is shown that these sensitivities give valuable information to identify critical generator-load pairs and locations for applying preventive control measures. [less ▲]

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See detailA performance indicator for structures under natural fire
Gernay, Thomas ULg; Franssen, Jean-Marc ULg

in Engineering Structures (2015), 100

Fires in buildings are characterized by a heating phase followed by a cooling phase, yet the effects of the latter on structures are not well covered in the current approaches to structural fire ... [more ▼]

Fires in buildings are characterized by a heating phase followed by a cooling phase, yet the effects of the latter on structures are not well covered in the current approaches to structural fire engineering. Indeed the actual requirement of non-occurrence of structural failure at peak temperature does not guarantee against a delayed failure during or after the cooling phase of a fire, which puts at risk the fire brigades and people proceeding to a building inspection after a fire. Therefore there is an urgent need to better comprehend and characterize the materials and structures behavior under decreasing temperatures. Sensitivity to delayed failure of a structural component depends on its typology and constituting materials. In particular, two structural components with the same Fire Resistance rating (R) under standardized fire may exhibit very distinct behavior under natural fire, one of them being more prone to delayed failure than the other. With the aim of quantifying this effect, a new indicator is proposed that characterizes the performance of structures under natural fire conditions. The paper presents the methodology to derive this new indicator as well as results for different typologies of structural components. Parametric analyses highlight the prime influence of constitutive material and thermal inertia of the element on the post-peak behavior. Used in conjunction with the Fire Resistance rating, it is shown how the new indicator carries additional and significant information for classifying structural systems in terms of their fire performance and propensity to delayed failure. [less ▲]

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See detailAn Ant Colony System for Responsive Dynamic Vehicle Routing
Schyns, Michael ULg

in European Journal of Operational Research (2015), 245(3), 704-718

We present an algorithm based on an Ant Colony System to deal with a broad range of Dynamic Capacitated Vehicle Routing Problems with Time Windows, (partial) Split Delivery and Heterogeneous fleets ... [more ▼]

We present an algorithm based on an Ant Colony System to deal with a broad range of Dynamic Capacitated Vehicle Routing Problems with Time Windows, (partial) Split Delivery and Heterogeneous fleets (DVRPTWSD). Besides the traditional distance criterion, we address the important case of responsiveness. Responsiveness is defined here as completing a delivery as soon as possible, within the time window, such that the client or the truck may restart its activities. This is crucial for many production or service activities in different fields: express parcel deliveries, taxi services, Just in Time production, express repair services, medical care, petrol station replenishment, etc. We develop an interactive web-based solution to allow dispatchers to take new information into account in real-time. The algorithm and its parametrization were tested on real and artificial instances. We first illustrate our approach with a problem submitted by Liege Airport, the 8th biggest cargo airport in Europe. The goal is to develop a decision system to optimize the journey of the refueling trucks. We then consider some classical VRP benchmarks with extensions for more complex problems. [less ▲]

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See detailA stochastic computational multiscale approach; Application to MEMS resonators
Lucas, Vincent ULg; Golinval, Jean-Claude ULg; Paquay, Stéphane et al

in Computer Methods in Applied Mechanics & Engineering (2015), 294

The aim of this work is to develop a stochastic multiscale model for polycrystalline materials, which accounts for the uncertainties in the micro-structure. At the finest scale, we model the micro ... [more ▼]

The aim of this work is to develop a stochastic multiscale model for polycrystalline materials, which accounts for the uncertainties in the micro-structure. At the finest scale, we model the micro-structure using a random Voronoi tessellation, each grain being assigned a random orientation. Then, we apply a computational homogenization procedure on statistical volume elements to obtain a stochastic characterization of the elasticity tensor at the meso-scale. A random field of the meso-scale elasticity tensor can then be generated based on the information obtained from the SVE simulations. Finally, using a stochastic finite element method, these meso-scale uncertainties are propagated to the coarser scale. As an illustration we study the resonance frequencies of MEMS micro-beams made of poly-silicon materials, and we show that the stochastic multiscale approach predicts results in agreement with a Monte Carlo analysis applied directly on the fine finite-element model, i.e. with an explicit discretization of the grains. [less ▲]

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See detailAn enhanced version of a bone remodelling model based on the continuum damage mechanics theory.
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in Computer Methods in Biomechanics & Biomedical Engineering (2015), 18(12), 1367-1376

The purpose of this work is to propose an enhancement of Doblaré and García's internal bone remodelling model based on the continuum damage mechanics theory. In their paper, they stated that the evolution ... [more ▼]

The purpose of this work is to propose an enhancement of Doblaré and García's internal bone remodelling model based on the continuum damage mechanics theory. In their paper, they stated that the evolution of the internal variables of the bone microstructure, and its incidence on the modification of the elastic constitutive parameters, may be formulated following the principles of Continuum Damage Mechanics, although no actual damage was considered. The resorption and apposition criteria (similar to the damage criterion) were expressed in terms of a mechanical stimulus. However, the resorption criterion is lacking a dimensional consistency with the remodelling rate. We here propose an enhancement to this resorption criterion, insuring the dimensional consistency while retaining the physical properties of the original remodelling model. We then analyse the change in the resorption criterion hypersurface in the stress space for a 2D analysis. We finally apply the new formulation to analyse the structural evolution of a 2D femur. This analysis gives results consistent with the original model but with a faster and more stable convergence rate. [less ▲]

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See detailCoupled modeling of Excavation Damaged Zone in Boom clay: Strain localization in rock and distribution of contact pressure on the gallery’s lining
Salehnia, Fatemeh ULg; Collin, Frédéric ULg; Li, Xiang Ling et al

in Computers and Geotechnics (2015), 69

Around galleries excavated at depth in geological media, the creation of a damaged zone with significant irreversible deformation is generally unavoidable. In the case of a geological disposal system for ... [more ▼]

Around galleries excavated at depth in geological media, the creation of a damaged zone with significant irreversible deformation is generally unavoidable. In the case of a geological disposal system for high-level radioactive waste, the resulting change in the host rock properties in this damaged zone may potentially be important with respect to the long-term evolution and the performance of that system. In this context, predicting the extent of the so-called Excavation Damaged Zone (EDZ) and, possibly, the fractures' network topology remains a challenge. This study is aimed to simulate numerically the extension of this zone at the large scale's excavation, around the Connecting gallery (HADES URL, Mol, Belgium), in Boom clay host rock through analyzing the evolution of strain localization in shear bands mode. To realistically model the involved phenomena, the concrete lining is considered on the gallery wall highlighting its impacts on the evolution of convergence and EDZ around the gallery. The focus of the current paper is made on analyzing the coupled hydro-mechanical behavior of Boom clay host rock during and after the gallery excavation with respect to the evolution of localized shear bands around the gallery. This study is accompanied by the analysis of the contact mechanism on the interface between the clay massive and the lining. The obtained results reveal some interesting features regarding the contact phenomenon relatively to the evolution pattern of shear bands within the clay around the gallery. To assess the reliability of the proposed approach, a discussion on some in-situ observations during the gallery's construction is also performed based on which a good agreement is found between the in-situ evidence and simulated results. [less ▲]

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See detailThe Airline Container Loading Problem with Pickup and Delivery
Lurkin, Virginie ULg; Schyns, Michael ULg

in European Journal of Operational Research (2015), 244(3), 955-965

This paper considers the loading optimization problem for a set of containers and pallets transported into a cargo aircraft that serves multiple airports. Because of pickup and delivery operations that ... [more ▼]

This paper considers the loading optimization problem for a set of containers and pallets transported into a cargo aircraft that serves multiple airports. Because of pickup and delivery operations that occur at intermediate airports, this problem is simultaneously a Weight & Balance Problem and a Sequencing Problem. Our objective is to minimize fuel and handling operation costs. This problem is shown to be NP-hard. We resort to a mixed integer linear program. Based on real-world data from a professional partner (TNT Airways), we perform numerical experiments using a standard B&C library. This approach yields better solutions than traditional manual planning, which results in substantial cost savings. [less ▲]

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See detailPerformance, robustness and sensitivity analysis of the nonlinear tuned vibration absorber
Detroux, Thibaut ULg; Habib, Giuseppe ULg; Masset, Luc ULg et al

in Mechanical Systems & Signal Processing (2015), 60-61

The nonlinear tuned vibration absorber (NLTVA) is a recently developed nonlinear absorber which generalizes Den Hartog׳s equal peak method to nonlinear systems. If the purposeful introduction of ... [more ▼]

The nonlinear tuned vibration absorber (NLTVA) is a recently developed nonlinear absorber which generalizes Den Hartog׳s equal peak method to nonlinear systems. If the purposeful introduction of nonlinearity can enhance system performance, it can also give rise to adverse dynamical phenomena, including detached resonance curves and quasiperiodic regimes of motion. Through the combination of numerical continuation of periodic solutions, bifurcation detection and tracking, and global analysis, the present study identifies boundaries in the NLTVA parameter space delimiting safe, unsafe and unacceptable operations. The sensitivity of these boundaries to uncertainty in the NLTVA parameters is also investigated. [less ▲]

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See detailA study of composite laminates failure using an anisotropic gradient-enhanced damage mean-field homogenization model
Wu, Ling ULg; Sket, Federico; Molina-Aldareguia, Jon M et al

in Composite Structures (2015), 126

The failure of carbon fiber reinforced epoxy laminates is studied using an anisotropic gradient-enhanced continuum damage model embedded in a mean-field homogenization scheme. In each ply, a homogenized ... [more ▼]

The failure of carbon fiber reinforced epoxy laminates is studied using an anisotropic gradient-enhanced continuum damage model embedded in a mean-field homogenization scheme. In each ply, a homogenized material law is used to capture the intra-laminar failure. The anisotropy of the homogenized material model results from the homogenization method and from the reformulation of the non-local continuum damage theory to account for the material anisotropy. As a result the damage propagation direction in each ply is predicted with accuracy as compared to the experimental results, while the problems of losing uniqueness and strain localization, which occur in classical finite element simulations when strain softening of materials is involved, can be avoided. To model the delamination process, the hybrid discontinuous Galerkin/extrinsic cohesive law method is introduced at the ply interfaces. This hybrid method avoids the need to propagate topological changes in the mesh with the propagation of the delamination while it preserves the consistency and stability in the un-cracked interfaces. As a demonstration, open-hole coupons with different stacking sequences are studied numerically and experimentally. Both the intra- and inter-laminar failure patterns are shown to be well captured by the computational framework. [less ▲]

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See detailCharacterizing activity sequences using Profile Hidden Markov Models
Liu, Feng; Janssens, Davy; Cui, JianXun et al

in Expert Systems with Applications (2015), 42(13), 57055722

In literature, activity sequences, generated from activity-travel diaries, have been analyzed and classified into clusters based on the composition and ordering of the activities using Sequence Alignment ... [more ▼]

In literature, activity sequences, generated from activity-travel diaries, have been analyzed and classified into clusters based on the composition and ordering of the activities using Sequence Alignment Methods (SAM). However, using these methods, only the frequent activities in each cluster are extracted and qualitatively described; the infrequent activities and their related travel episodes are disregarded. Thus, to quantify the occurrence probabilities of all the daily activities as well as their sequential orders, we develop a novel process to build multiple alignments of the sequences and subsequently derive profile Hidden Markov Models (pHMMs). This process consists of 4 major steps. First, activity sequences are clustered based on a pre-defined scheme. The frequent activities along with their sequential orders are then identified in each cluster, and they are subsequently used as a template to guide the construction of a multiple alignment of the cluster of sequences. Finally, a pHMM is employed to convert the multiple alignment into a position-specific scoring system, representing the probability of each frequent activity at each important position of the alignment as well as the probabilities of both insertion and deletion of infrequent activities. By applying the derived pHMMs to a set of activity-travel diaries collected in Belgium as well as a group of mobile phone call location data recorded in Switzerland, the potential and effectiveness of the models in capturing the sequential features of each cluster and distinguishing them from those of other clusters, are demonstrated. The proposed method can also be utilized to improve activity-based transportation model validation and travel survey designs. Furthermore, it offers a wide application in characterizing a group of any related sequences, particularly sequences varying in length and with a high frequency of short sequences that are typically present in human behavior. [less ▲]

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See detailDevelopment, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Mbinze Kidenge, Jérémie; Sacre, Pierre-Yves ULg; Yemoa, Achille et al

in Journal of Pharmaceutical & Biomedical Analysis (2015), 111

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient ... [more ▼]

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and Near Infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50-150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC). [less ▲]

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See detailDrug loading of polymer implants by supercritical CO2 assisted impregnation: a review
Champeau, Mathilde; Thomassin, Jean-Michel ULg; Tassaing, Thierry et al

in Journal of Controlled Release (2015), 209

Drug loaded implants also called drug-eluting implants have proven their benefits over simple implants. Among the developed manufacturing processes, the supercritical CO2 (scCO2) assisted impregnation has ... [more ▼]

Drug loaded implants also called drug-eluting implants have proven their benefits over simple implants. Among the developed manufacturing processes, the supercritical CO2 (scCO2) assisted impregnation has attracted growing attention to load Active Pharmaceutical Ingredients into polymer implants since it enables to recover a final implant free of any solvent residue and to operate under mild temperature which is suitable for processing with thermosensitive drugs. This paper is a review of the state-of-the-art and the application of the scCO2 assisted impregnation process to prepare drug-eluting implants. It introduces the process and presents its advantages for biomedical applications. The influences of the characteristics of the implied binary systems and of the experimental conditions on the drug loading are described. Then, the various current applications of this process for manufacturing drug-eluting implants are reviewed. Finally, the new emerging variations of this process are described. [less ▲]

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See detailVersion française de la Distress Tolerance Scale et de la Discomfort Intolerance Scale
Wagener, Aurélie ULg; Blairy, Sylvie ULg

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2015), 3(47),

The perceived perspective of the distress tolerance refers to the perceived ability to experience and to withstand negative emotional states and/or other aversive sensations (e.g. physical discomfort ... [more ▼]

The perceived perspective of the distress tolerance refers to the perceived ability to experience and to withstand negative emotional states and/or other aversive sensations (e.g. physical discomfort). Two scales were developed to assess this construct: the Distress Tolerance Scale (DTS) and the Discomfort Intolerance Scale (DIS). The objective of this investigation is to present the validation of these two scales in French. 488 non-clinical adults completed an online survey assessing the distress tolerance and emotional regulation strategies. Factor analyses were performed to determine the factor structures of the French versions of these scales. CFA highlighted a four-factor solution (tolerance, absorption, appraisal, regulation) with one higher-order factor (general distress tolerance) as being the better fit for the DTS. CFA highlighted a two-factor solution (intolerance and avoidance) with one higher-order factor (general discomfort intolerance) as being the better fit for the DIS. Intern and extern validity were assessed and demonstrated good properties. [less ▲]

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See detailPolarization alignments of quasars from the JVAS/CLASS 8.4-GHz surveys
Pelgrims, Vincent ULg; Hutsemekers, Damien ULg

in Monthly Notices of the Royal Astronomical Society (2015), 450

We test the hypothesis that the polarization vectors of flat-spectrum radio sources (FSRSs) from the JVAS/CLASS 8.4-GHz surveys are randomly oriented in the sky. A sample with robust polarization ... [more ▼]

We test the hypothesis that the polarization vectors of flat-spectrum radio sources (FSRSs) from the JVAS/CLASS 8.4-GHz surveys are randomly oriented in the sky. A sample with robust polarization measurements is made with 4155 objects. Redshift information is known for 1531 of them. We performed two statistical analyses: one in two dimensions and the other in three dimensions when distance is available. We find significant large-scale alignments of polarization vectors for samples containing only quasars among the varieties of FSRS. While these correlations prove difficult to explain either by a physical effect or by biases in the data set, that the quasars that have significantly aligned polarization vectors are found in regions of the sky where optical polarization alignments were previously found is striking. [less ▲]

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See detailBiomechanical Analysis of Abdominal Injury in Tennis Serves. A Case Report
Tubez, François ULg; Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg et al

in Journal of Sports Science & Medicine (2015), 14

The serve is an important stroke in any high level tennis game. A well-mastered serve is a substantial advantage for players. However, because of its repeatability and its intensity, this stroke is ... [more ▼]

The serve is an important stroke in any high level tennis game. A well-mastered serve is a substantial advantage for players. However, because of its repeatability and its intensity, this stroke is potentially deleterious for upper limbs, lower limbs and trunk. The trunk is a vital link in the production and transfer of energy from the lower limbs to the upper limbs; therefore, kin-ematic disorder could be a potential source of risk for trunk injury in tennis. This research studies the case of a professional tennis player who has suffered from a medical tear on the left rectus abdominis muscle after tennis serve. The goal of the study is to understand whether the injury could be explained by an inappropriate technique. For this purpose, we analyzed in three dimensions the kinematic and kinetic aspects of the serve. We also performed isokinetic tests of the player’s knees. We then compared the player to five other professional players as refer-ence. We observed a possible deficit of energy transfer because of an important anterior pelvis tilt. Some compensation made by the player during the serve could be a possible higher abdominal contraction and a larger shoulder external rotation. These partic-ularities could induce an abdominal overwork that could explain the first injury and may provoke further injuries. [less ▲]

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See detailWASP-80b has a dayside within the T-dwarf range
Triaud, Amaury H. M. J.; Gillon, Michaël ULg; Ehrenreich, David et al

in Monthly Notices of the Royal Astronomical Society (2015), 450

WASP-80b is a missing link in the study of exoatmospheres. It falls between the warm Neptunes and the hot Jupiters and is amenable for characterization, thanks to its host star's properties. We observed ... [more ▼]

WASP-80b is a missing link in the study of exoatmospheres. It falls between the warm Neptunes and the hot Jupiters and is amenable for characterization, thanks to its host star's properties. We observed the planet through transit and during occultation with Warm Spitzer. Combining our mid-infrared transits with optical time series, we find that the planet presents a transmission spectrum indistinguishable from a horizontal line. In emission, WASP-80b is the intrinsically faintest planet whose dayside flux has been detected in both the 3.6 and 4.5 μm Spitzer channels. The depths of the occultations reveal that WASP-80b is as bright and as red as a T4 dwarf, but that its temperature is cooler. If planets go through the equivalent of an L-T transition, our results would imply that this happens at cooler temperatures than for brown dwarfs. Placing WASP-80b's dayside into a colour-magnitude diagram, it falls exactly at the junction between a blackbody model and the T-dwarf sequence; we cannot discern which of those two interpretations is the more likely. WASP-80b's flux density is as low as GJ 436b at 3.6 μm; the planet's dayside is also fainter, but bluer than HD 189733Ab's nightside (in the [3.6] and [4.5]Spitzer bands). Flux measurements on other planets with similar equilibrium temperatures are required to establish whether irradiated gas giants, such as brown dwarfs, transition between two spectral classes. An eventual detection of methane absorption in transmission would also help lift that degeneracy. We obtained a second series of high-resolution spectra during transit, using HARPS. We reanalyse the Rossiter-McLaughlin effect. The data now favour an aligned orbital solution and a stellar rotation nearly three times slower than stellar line broadening implies. A contribution to stellar line broadening, maybe macroturbulence, is likely to have been underestimated for cool stars, whose rotations have therefore been systematically overestimated. [less ▲]

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See detailRuthenium–arene catalysts bearing N-heterocyclic carbene ligands for olefin cyclopropanation and metathesis
Méret, M.; Maj, A. M.; Demonceau, Albert ULg et al

in Monatshefte für Chemie = Chemical Monthly (2015), 146(7), 1099-1105

Abstract: Ruthenium–arene complexes bearing N-heterocyclic carbene (NHC) ligands with the generic formula [RuCl2(p-cymene)(NHC)] are efficient catalyst precursors for the cyclopropanation of activated ... [more ▼]

Abstract: Ruthenium–arene complexes bearing N-heterocyclic carbene (NHC) ligands with the generic formula [RuCl2(p-cymene)(NHC)] are efficient catalyst precursors for the cyclopropanation of activated olefins with ethyl diazoacetate, and the cis/trans diastereoselectivity of the reaction markedly depends on the steric bulk of the NHC. The procedure was successfully applied to styrene, α-methylstyrene, and various other styrenic derivatives bearing electron-withdrawing or donating substituents on their aromatic rings. The reaction of unactivated internal or terminal alkenes was more sluggish, and the use of norbornene as a substrate afforded only olefin metathesis. Further investigation of the ring-opening metathesis polymerization of this strained cycloolefin in the presence of trimethylsilyldiazomethane led to high molecular weight polynorbornene whose microstructure was not significantly affected by the choice of the NHC ancillary ligand. [less ▲]

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See detailLa Belgique ‘officielle’ face à l’OAS (1961-1964). Cas d’une adaptation de Bruxelles à la politique du général De Gaulle
Genin, Vincent ULg

in Revue du Nord (2015), 406 (octobre-décembre 2014)(96), 917-935

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See detailShould ABO-incompatible deceased liver transplantation be reconsidered?
Detry, Olivier ULg

in Transplant international : official journal of the European Society for Organ Transplantation (2015), 28(7), 788-9

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See detailConnections between the design tool, design attributes, and user preferences in early stage design
Häggman, Anders; Tsai, Geoff; Elsen, Catherine ULg et al

in Journal of Mechanical Design (2015), 137(7), 13

Gathering user feedback on provisional design concepts early in the design process has the potential to reduce time-to-market and create more satisfying products. Among the parameters that shape user ... [more ▼]

Gathering user feedback on provisional design concepts early in the design process has the potential to reduce time-to-market and create more satisfying products. Among the parameters that shape user response to a product, this paper investigates how design experts use sketches, physical prototypes, and computer-aided design (CAD) to generate and represent ideas, as well as how these tools are linked to design attributes and multiple measures of design quality. Eighteen expert designers individually addressed a 2 hr design task using only sketches, foam prototypes, or CAD. It was found that prototyped designs were generated more quickly than those created using sketches or CAD. Analysis of 406 crowdsourced responses to the resulting designs showed that those created as prototypes were perceived as more novel, more aesthetically pleasing, and more comfortable to use. It was also found that designs perceived as more novel tended to fare poorly on all other measured qualities. [less ▲]

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See detailIdesbald Goddeeris, La Grande Emigration polonaise en Belgique (1831-1870). Elites et masses en exil à l’époque romantique, Francfort-sur-le-Main, P.I.E. Peter Lang, 2013, 552 p.
Genin, Vincent ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2015), XXXVII(2), 18-19

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See detailModel-based computation of total stressed blood volume from a preload reduction manoeuvre
Pironet, Antoine ULg; Desaive, Thomas ULg; Chase, J. Geoffrey et al

in Mathematical Biosciences (2015), 265(0), 28-39

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid therapy, a primary treatment ... [more ▼]

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid therapy, a primary treatment to manage acute circulatory failure. From an engineering point of view, it dictates the cardiovascular system’s behavior in changing physiological situations. Current methods to determine this parameter involve repeated phases of circulatory arrests followed by fluid administration. In this work, a more straightforward method is developed using data from a preload reduction manoeuvre. A simple six-chamber cardiovascular system model is used and its parameters are adjusted to pig experimental data. The parameter adjustment process has three steps: (1) compute nominal values for all model parameters; (2) determine the five most sensitive parameters; and (3) adjust only these five parameters. Stressed blood volume was selected by the algorithm, which emphasizes the importance of this parameter. The model was able to track experimental trends with a maximal root mean squared error of 29.2%. Computed stressed blood volume equals 486 ± 117 ml or 15.7 ± 3.6 ml/kg, which matches previous independent experiments on pigs, dogs and humans. The method proposed in this work thus provides a simple way to compute total stressed blood volume from usual hemodynamic data. [less ▲]

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See detailReinforcement Learning of Heuristic EV Fleet Charging in a Day-Ahead Electricity Market
Vandael, Stijn; Claessens, Bert; Ernst, Damien ULg et al

in IEEE Transactions on Smart Grid (2015), 6(4), 1795-1805

This paper addresses the problem of defining a day-ahead consumption plan for charging a fleet of electric vehicles (EVs), and following this plan during operation. A challenge herein is the beforehand ... [more ▼]

This paper addresses the problem of defining a day-ahead consumption plan for charging a fleet of electric vehicles (EVs), and following this plan during operation. A challenge herein is the beforehand unknown charging flexibility of EVs, which depends on numerous details about each EV (e.g., plug-in times, power limitations, battery size, power curve, etc.). To cope with this challenge, EV charging is controlled during opertion by a heuristic scheme, and the resulting charging behavior of the EV fleet is learned by using batch mode reinforcement learning. Based on this learned behavior, a cost-effective day-ahead consumption plan can be defined. In simulation experiments, our approach is benchmarked against a multistage stochastic programming solution, which uses an exact model of each EVs charging flexibility. Results show that our approach is able to find a day-ahead consumption plan with comparable quality to the benchmark solution, without requiring an exact day-ahead model of each EVs charging flexibility. [less ▲]

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See detailSemiótica de la acción: textualización y notación
Dondero, Maria Giulia ULg

in Tópicos del seminario (2015), 33

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining ... [more ▼]

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining the forms of enunciative praxis through different levels of pertinence analysis. Secondly, we propose the concept of ‘textualization’ as a mediation between text and action: textualizations (photographs, videos, notes) organize and represent practices which are in themselves ephemeral and elusive. Finally, we will consider the textual diagrammatization that we call ‘notation’: this analytical form of mediation between text and practice does not have the same status of in-vivo textualisations, but it works like an ex-post reconstruction which highlights the main gestures and exchanges while performing their grammaticalization. A more general aim of this essay is an enquiry into the legitimate objects of textual semiotics: what are the objects that it can analyze without betraying its principle of immanence, but also without being confined to it and, as a consequence, being unable to analyze practices and respond to topical questions on social issues and on the research in the human sciences? [less ▲]

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See detailThe Geoarchaeology of Utica, Tunisia: The Paleogeography of the Mejerda Delta and Hypotheses Concerning the Location of the Ancient Harbor
Delile, Hugo; Abichou; Gadhoum, Ahmed et al

in Geoarchaeology (2015), 30(4), 291-306

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See detailCorporate Disclosures, Information Asymmetry and Stock-Market Liquidity in France
Sougné, Danielle ULg; Ajina, Aymen; Lakhal, Faten

in Journal of Applied Business Research (2015), Vol 31(4),

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of ... [more ▼]

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of information included in the annual reports on investor’s behavior. This is proxied by the information asymmetry component of the bid-ask spread and stock market liquidity. Our sample includes 196 French listed firms over a period ranging from 2004 to 2007. We opt for an explanatory study using OLS regressions to examine the nature of the relationship between information disclosed in annual reports and bid-ask spreads a proxy for information asymmetry and stock market liquidity. The results show that the extent of corporate disclosures in annual reports positively influences the liquidity of the French market and negatively affects the adverse selection component of the bid-ask spread. This effect is further confirmed by the commitment to IFRS by French-listed firms from 2005. The decomposition of the total score in the sub-indices shows that non-financial and financial information are important in trading decisions while strategic information may be attractive only for long-term positions [less ▲]

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See detailSpectroscopic survey of Kepler stars. I. HERMES/Mercator observations of A- and F-type stars
Niemczura, E.; Murphy, S. J.; Smalley, B. et al

in Monthly Notices of the Royal Astronomical Society (2015), 450

The Kepler space mission provided near-continuous and high-precision photometry of about 207,000 stars, which can be used for asteroseismology. However, for successful seismic modelling it is equally ... [more ▼]

The Kepler space mission provided near-continuous and high-precision photometry of about 207,000 stars, which can be used for asteroseismology. However, for successful seismic modelling it is equally important to have accurate stellar physical parameters. Therefore, supplementary ground-based data are needed. We report the results of the analysis of high-resolution spectroscopic data of A- and F-type stars from the Kepler field, which were obtained with the HERMES spectrograph on the Mercator telescope. We determined spectral types, atmospheric parameters and chemical abundances for a sample of 117 stars. Hydrogen Balmer, Fe I, and Fe II lines were used to derive effective temperatures, surface gravities, and microturbulent velocities. We determined chemical abundances and projected rotational velocities using a spectrum synthesis technique. The atmospheric parameters obtained were compared with those from the Kepler Input Catalogue (KIC), confirming that the KIC effective temperatures are underestimated for A stars. Effective temperatures calculated by spectral energy distribution fitting are in good agreement with those determined from the spectral line analysis. The analysed sample comprises stars with approximately solar chemical abundances, as well as chemically peculiar stars of the Am, Ap, and Lambda Boo types. The distribution of the projected rotational velocity, Vsini, is typical for A and F stars and ranges from 8 to about 280 km/s, with a mean of 134 km/s. [less ▲]

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See detailAn XFEM/CZM implementation for massively parallel simulations of composites fracture
Vigueras, Guillermo; Sket, Federico; Samaniego, Cristobal et al

in Composite Structures (2015), 125

Because of their widely spread use in many industries, composites are the subject of many research campaigns. More particularly, the development of both accurate and flexible numerical models able to ... [more ▼]

Because of their widely spread use in many industries, composites are the subject of many research campaigns. More particularly, the development of both accurate and flexible numerical models able to capture their intrinsically multiscale modes of failure is still a challenge. The standard finite element method typically requires intensive remeshing to adequately capture the geometry of the cracks and high accuracy is thus often sacrificed in favor of scalability, and vice versa. In an effort to preserve both properties, we present here an extended finite element method (XFEM) for large scale composite fracture simulations. In this formulation, the standard FEM formulation is partially enriched by use of shifted Heaviside functions with special attention paid to the scalability of the scheme. This enrichment technique offers several benefits, since the interpolation property of the standard shape function still holds at the nodes. Those benefits include (i) no extra boundary condition for the enrichment degree of freedom, and (ii) no need for transition/blending regions; both of which contribute to maintain the scalability of the code. Two different cohesive zone models (CZM) are then adopted to capture the physics of the crack propagation mechanisms. At the intralaminar level, an extrinsic CZM embedded in the XFEM formulation is used. At the interlaminar level, an intrinsic CZM is adopted for predicting the failure. The overall framework is implemented in ALYA, a mechanics code specifically developed for large scale, massively parallel simulations of coupled multi-physics problems. The implementation of both intrinsic and extrinsic CZM models within the code is such that it conserves the extremely efficient scalability of ALYA while providing accurate physical simulations of computationally expensive phenomena. The strong scalability provided by the proposed implementation is demonstrated. The model is ultimately validated against a full experimental campaign of loading tests and X-ray tomography analyses for a chosen very large scale. [less ▲]

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See detailLong-term XMM-Newton investigation of two particle-accelerating colliding-wind binaries in NGC6604: HD168112 and HD167971
De Becker, Michaël ULg

in Monthly Notices of the Royal Astronomical Society (2015), 451(1), 5589-5599

The long-term (over more than one decade) X-ray emission from two massive stellar systems known to be particle accelerators is investigated using XMM-Newton. Their X-ray properties are interpreted taking ... [more ▼]

The long-term (over more than one decade) X-ray emission from two massive stellar systems known to be particle accelerators is investigated using XMM-Newton. Their X-ray properties are interpreted taking into account recent information about their multiplicity and orbital parameters. The two targets, HD168112 and HD167971 appear to be overluminous in X-rays, lending additional support to the idea that a significant contribution of the X-ray emission comes from colliding-wind regions. The variability of the X-ray flux from HD168112 is interpreted in terms of varying separation expected to follow the 1/D rule for adiabatic shocked winds. For HD167971, marginal decrease of the X-ray flux in September 2002 could tentatively be explained by a partial wind eclipse in the close pair. No long-term variability could be demonstrated despite the significant difference of separation between 2002 and 2014. This suggests the colliding-wind region in the wide orbit does not contribute a lot to the total X-ray emission, with a main contribution coming from the radiative shocked winds in the eclipsing pair. The later result provides evidence that shocks in a colliding-wind region may be efficient particle accelerators even in the absence of bright X-ray emission, suggesting particle acceleration may operate in a wide range of conditions. Finally, in hierarchical triple O-type systems, thermal X-rays do not necessarily constitute an efficient tracer to detect the wind-wind interaction in the long period orbit. [less ▲]

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See detailSemiótica de la acción: textualización y notación
Dondero, Maria Giulia ULg

in Tópicos del seminario (2015), 33

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining ... [more ▼]

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining the forms of enunciative praxis through different levels of pertinence analysis. Secondly, we propose the concept of ‘textualization’ as a mediation between text and action: textualizations (photographs, videos, notes) organize and represent practices which are in themselves ephemeral and elusive. Finally, we will consider the textual diagrammatization that we call ‘notation’: this analytical form of mediation between text and practice does not have the same status of in-vivo textualisations, but it works like an ex-post reconstruction which highlights the main gestures and exchanges while performing their grammaticalization. A more general aim of this essay is an enquiry into the legitimate objects of textual semiotics: what are the objects that it can analyze without betraying its principle of immanence, but also without being confined to it and, as a consequence, being unable to analyze practices and respond to topical questions on social issues and on the research in the human sciences? [less ▲]

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See detailCould alternative solanaceous hosts act as refuges for the tomato leafminer, Tuta absoluta?
Bawin, Thomas ULg; Dujeu, David ULg; De Backer, Lara ULg et al

in Arthropod-Plant Interactions (2015)

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous plants. The characterization of its effective ... [more ▼]

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous plants. The characterization of its effective host range could help to understand and prevent the dispersion behavior of the insect in the environment. In this study, the ability of T. absoluta to locate and develop on wild (Solanum nigrum, Atropa belladonna, Datura stramonium) and cultivated (Solanum tuberosum) solanaceous plant species under laboratory conditions was assessed. Dual-choice behavioral assays performed in flying tunnels (S. tuberosum versus another plant) revealed that adult distribution and female oviposition did not differ between Solanum species, which were preferred to the other tested plants. The volatile molecules released by each tested plant species provide some explanations in the observed behavioral discrimination: S. nigrum and S. tuberosum volatile profiles were similar, and were presenting quantitative and qualitative differences with the other tested Solanaceous plants. To determine whether the host plant choice was adaptive or not, we have finally conducted fitness assays, by rearing T. absoluta larvae on each plant species and have shown that Solanum species allowed higher larval survivability and lower development time (from egg to adult emergency) compared to the other plants. We conclude that Solanum species are suitable host plants for T. absoluta, but other Solanaceous plant species could be opportunistically colonized with fewer incidences. [less ▲]

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See detailMetal bioavailability and bioaccumulation in the polychaete Nereis virens (Sars): the effects of site-specific sediment characteristics
Pini, Jennifer; Richir, Jonathan ULg; Watson, Gordon

in Marine Pollution Bulletin (2015), 95(2), 565575

The present study investigates the relationships between copper (Cu) and zinc (Zn) concentrations in sediment, pore water and their bioaccumulation in the polychaete Nereis (Alitta) virens, as well as the ... [more ▼]

The present study investigates the relationships between copper (Cu) and zinc (Zn) concentrations in sediment, pore water and their bioaccumulation in the polychaete Nereis (Alitta) virens, as well as the importance of site-specific sediment characteristics in that process. Sediment, pore water and N. virens were sampled from seven sites with different pollution histories along the English Channel coast. Results showed that site-specific metal levels and sediment characteristics were important in determining the bioavailability of metals to worms. Significant correlations were found between Cu in the sediment and in the pore water and between Zn in the pore water and in N. virens. Zn from the pore water was thus more readily available from a dissolved source to N. virens than Cu. Data also showed that metal concentrations in N. virens were lower than those found in other closely related polychaetes, indicating that it may regulate tissue concentrations of Cu and Zn. [less ▲]

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See detailMultiscale structure characterization of sawdust-waste water sludge extrudates dried in a pilot-scale fixed bed
Li, Jie ULg; Plougonven, Erwan ULg; Fraikin, Laurent ULg et al

in Biomass and Bioenergy (2015), 81(0), 98-107

Abstract Convective drying of waste water sludge and sawdust-sludge mixtures in a pilot-scale fixed bed was studied. Drying was performed in a cross-flow convective dryer using 500 g of wet material ... [more ▼]

Abstract Convective drying of waste water sludge and sawdust-sludge mixtures in a pilot-scale fixed bed was studied. Drying was performed in a cross-flow convective dryer using 500 g of wet material extruded through a disk with circular dies 12 mm in diameter. The structure of the bed mainly shows volume shrinkage and crack formation during drying. Several characterization techniques were used over a wide range of scales from nm up to mm. The overall bed structure was imaged with X-ray macrotomography, at a resolution of 0.36 mm per pixel. Single extrudates were scanned with X-ray microtomography, at a resolution of 41 μm per pixel. Pore structure of the dried samples were characterized by mercury porosimetry (7.5 nm < dp < 150 μm). Results show significant structural changes on all scales with increasing amounts of sawdust: shrinkage decreases, crack formation increases, and the pores become larger. This confirms the benefits of sawdust addition for sludge drying applications. [less ▲]

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See detailAging mechanisms in amorphous phase-change materials
Raty, Jean-Yves ULg; Zhang, wei; Luckas, Jennifer et al

in Nature Communications (2015), 6(7467), 1-8

Aging is a ubiquitous phenomenon in glasses. In the case of phase-change materials, it leads to a drift in the electrical resistance, which hinders the development of ultrahigh density storage devices ... [more ▼]

Aging is a ubiquitous phenomenon in glasses. In the case of phase-change materials, it leads to a drift in the electrical resistance, which hinders the development of ultrahigh density storage devices. Here we elucidate the aging process in amorphous GeTe, a prototypical phase-change material, by advanced numerical simulations, photothermal deflection spectroscopy and impedance spectroscopy experiments. We show that aging is accompanied by a progressive change of the local chemical order towards the crystalline one. Yet, the glass evolves towards a covalent amorphous network with increasing Peierls distortion, whose structural and electronic properties drift away from those of the resonantly bonded crystal. This behaviour sets phase-change materials apart from conventional glass-forming systems, which display the same local structure and bonding in both phases [less ▲]

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See detailGalectin-3 and suppression of tumorignenicity 2 measurment in participat at the "Tor des Géants"
LE GOFF, Caroline ULg

in Final programme European College of sport Science (2015)

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See detailSuperstudio’s Dystopian Tales: Textual and Graphic Practice as Operational Method
Prina, Daniela ULg

in Writing Visual Culture (2015), 6

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See detailHigh-dose oral intake of serotonin induces valvular heart disease in rabbits.
Lancellotti, Patrizio ULg; NCHIMI LONGANG, Alain ULg; Hego, Alexandre ULg et al

in International Journal of Cardiology (2015), 197

Carcinoid tumors are rare neuroendocrine malignancies, often originating from enterochromaffin cells in the gastrointestinal tract. They can secrete serotonin (5-hydroxytryptamine, 5-HT), which is largely ... [more ▼]

Carcinoid tumors are rare neuroendocrine malignancies, often originating from enterochromaffin cells in the gastrointestinal tract. They can secrete serotonin (5-hydroxytryptamine, 5-HT), which is largely inactivated by the liver. Carcinoid heart disease occurs when tumor cells metastasize to the liver, as the vasoactive substances produced are able to reach the systemic circulation via the hepatic vein, causing deposition of fibrous tissue on the endocardial surfaces of the heart. It is predominantly manifested by right-sided valvular heart disease (VHD). Scavenging enzymes in the pulmonary endothelium may explain why left-sided cardiac involvement is unusual. The severity of cardiac damage is correlated with the plasmatic levels of serotonin, but the lowspecificity of serotonin for cardiac damage suggests that serotonin may be necessary but not sufficient to induce cardiac lesions. Therefore, other factors combined with serotonin might be required to induce VHD. However, recent animal studies confirmed the development of carcinoid-like valvular deposits in rats after 3 months of daily subcutaneous/intraperitoneal serotonin injections to avoid the liver first-pass clearance.Whether oral administration of serotonin can also induce VHD is unknown. We hypothesized that long-term oral serotonin overload in rabbits can lead to VHD, mimicking serotonin-induced lesions of carcinoid heart disease. We demonstrate, for the first time that high dose long-term oral administration of serotonin can lead to VHD in rabbits. [less ▲]

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See detailUncertainty of climate change impact on groundwater reserves – Application to a chalk aquifer
Goderniaux, Pascal; Brouyère, Serge ULg; Wildemeersch, Samuel et al

in Journal of Hydrology (2015), 528

Recent studies have evaluated the impact of climate change on groundwater resources for different geographical and climatic contexts. However, most studies have either not estimated the uncertainty around ... [more ▼]

Recent studies have evaluated the impact of climate change on groundwater resources for different geographical and climatic contexts. However, most studies have either not estimated the uncertainty around projected impacts or have limited the analysis to the uncertainty related to climate models. In this study, the uncertainties around impact projections from several sources (climate models, natural variability of the weather, hydrological model calibration) are calculated and compared for the Geer catchment (465 km2) in Belgium. We use a surface–subsurface integrated model implemented using the finite element code HydroGeoSphere, coupled with climate change scenarios (2010–2085) and the UCODE_2005 inverse model, to assess the uncertainty related to the calibration of the hydrological model. This integrated model provides a more realistic representation of the water exchanges between surface and subsurface domains and constrains more the calibration with the use of both surface and subsurface observed data. Sensitivity and uncertainty analyses were performed on predictions. The linear uncertainty analysis is approximate for this nonlinear system, but it provides some measure of uncertainty for computationally demanding models. Results show that, for the Geer catchment, the most important uncertainty is related to calibration of the hydrological model. The total uncertainty associated with the prediction of groundwater levels remains large. By the end of the century, however, the uncertainty becomes smaller than the predicted decline in groundwater levels. [less ▲]

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See detailLandscape Control on the Spatial and Temporal Variability of Chromophoric Dissolved Organic Matter and Dissolved Organic Carbon in Large African Rivers
Lambert, Thibault ULg; Darchambeau, François ULg; Bouillon, Steven et al

in Ecosystems (2015)

The characteristics of colored dissolved organic matter (CDOM) as well as the concentrations and stable isotope composition (d 13 C) of dissolved organic carbon (DOC) were characterized in several large ... [more ▼]

The characteristics of colored dissolved organic matter (CDOM) as well as the concentrations and stable isotope composition (d 13 C) of dissolved organic carbon (DOC) were characterized in several large rivers of Africa including the Congo, Niger, Zambezi, and Ogooué basins. We compared the spatial and temporal patterns of dissolved organic matter (DOM) quantity and quality along with various environmental gradients, including hydrology, river size, catchment vegetation, and connectivity to land. The optical proxies used include the absorption coefficient at 350 nm, the specific ultraviolet absorbance, and the spectral slope ratio (S R = 275–295-nm slope divided by 350–400-nm slope). Our results show that land cover plays a primary role in controlling both DOC concentration and optical properties of DOM in tropical freshwaters. A higher cover of dense forest in the catchment leads to a higher quantity of highly aromatic DOM in the river network, whereas an increasing savannah cover results in lower DOC concentrations and less absorptive DOM. In addition to land cover, the watershed morphology (expressed by the average slope) exerts a strong control on DOC and CDOM in tropical rivers. Our results also show that the percentage of C3 and C4 vegetation cover is not an accurate predictor for DOM and CDOM quality in rivers due to the importance of the spatial distribution of land cover within the drainage network. The comparison of our results with previously published CDOM data in temperate and high-latitude rivers highlights that DOM in tropical freshwa-ters is generally more aromatic, and shows a higher capacity for absorbing sunlight irradiance. [less ▲]

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See detailLa limitation du cumul de mandats par les députés wallons
Grandjean, Geoffrey ULg

in Courrier Hebdomadaire du CRISP (2015), 2255-2256

En moyenne, les représentants politiques belges cumulent entre cinq et huit mandats (dont la moitié sont rémunérés). Cette pratique contribue au développement des sentiments de méfiance que nourrit une ... [more ▼]

En moyenne, les représentants politiques belges cumulent entre cinq et huit mandats (dont la moitié sont rémunérés). Cette pratique contribue au développement des sentiments de méfiance que nourrit une partie de la population à l’égard des élus et des institutions. Dans un souci de bonne gouvernance, de nombreux citoyens et acteurs politiques appellent dès lors à une limitation des possibilités légales de cumul de mandats. La traduction récente la plus emblématique de cette préoccupation éthique est le décret décumul adopté en Région wallonne en 2010. Désormais, un député wallon n’a plus le droit de cumuler son mandat avec une fonction de bourgmestre, d’échevin ou de président d’un conseil de l’action sociale. Un quart des membres de chaque groupe politique représenté au Parlement wallon est cependant autorisé à cumuler. Les députés qui bénéficient de cette exception sont désignés sur la base de leur taux de pénétration électorale. Ce mécanisme est le fruit d’un accord politique conclu entre les partenaires du gouvernement régional (PS, Écolo, CDH). Son adoption a fait l’objet de débats nombreux et souvent tendus entre les partis politiques, en ce compris au sein de la majorité. Ce Courrier hebdomadaire retrace l’ensemble du processus législatif à la base du décret décumul. Il replace l’initiative dans son contexte et analyse le jeu des différents acteurs, en réservant une attention particulière aux divers arguments politiques, techniques et surtout juridiques qui ont été mobilisés. G. Grandjean se penche également sur les effets que le décret a eus pour les députés élus lors du scrutin régional wallon du 25 mai 2014. Enfin, il s’interroge sur l’avenir du décret décumul, que certains voudraient réformer, voire supprimer. [less ▲]

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See detailMAVEN IUVS observations of the aftermath of the Comet Siding Spring meteor shower on Mars
Schneider, Nick; Deighan, Justin; Stewart, Ian et al

in Geophysical Research Letters (2015)

We report the detection of intense emission from magnesium and iron in Mars' atmosphere caused by a meteor shower following Comet Siding Spring's close encounter with Mars. The observations were made with ... [more ▼]

We report the detection of intense emission from magnesium and iron in Mars' atmosphere caused by a meteor shower following Comet Siding Spring's close encounter with Mars. The observations were made with the Imaging Ultraviolet Spectrograph, a remote sensing instrument on the Mars Atmosphere and Volatile EvolutioN spacecraft orbiting Mars. Ionized magnesium caused the brightest emission from the planet's atmosphere for many hours, resulting from resonant scattering of solar ultraviolet light. Modeling suggests a substantial fluence of low-density dust particles 1–100 µm in size, with the large amount and small size contrary to predictions. The event created a temporary planet-wide ionospheric layer below Mars' main dayside ionosphere. The dramatic meteor shower response at Mars is starkly different from the case at Earth, where a steady state metal layer is always observable but perturbations caused by even the strongest meteor showers are challenging to detect. [less ▲]

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See detailImpact of Different Thermal Comfort Models on Zero Energy Residential Buildings in Hot Climate
Attia, Shady ULg; Carlucci, Salvatore

in Energy & Buildings (2015)

The selection of a thermal comfort model for establishing indoor optimal hygrothermal conditions during the hot period has a major impact on energy consumption of Net Zero Energy Buildings in hot climates ... [more ▼]

The selection of a thermal comfort model for establishing indoor optimal hygrothermal conditions during the hot period has a major impact on energy consumption of Net Zero Energy Buildings in hot climates. The objective of this paper is to compare the influence of using different thermal comfort models for zero energy buildings in hot climates. The paper compares the impact of applying Fanger’s model, Givoni’s model, the ASHRAE 55 adaptive comfort model and the EN 15251 adaptive comfort model on energy consumption and comfort performance. Using both the building performance simulation tools ZEBO and EnergyPlus for energy simulation, an existing prototype of a residential apartment module is used to evaluate energy performance and thermal comfort in two parametric series. The first one is the result of coupling natural ventilation and mechanical cooling and the second one is guided coupling natural ventilation, mechanical cooling and ceiling fans. This study shows that the percentage of energy consumption difference meeting the comfort criteria according to ISO 7730 in comparison to EN 15251, ASHRAE 55 or Givoni’s model varied up to 16%, 21% and 24.7% respectively for the presented case study. More energy savings can be expected for buildings in hot climates with greater cooling demands. [less ▲]

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See detailCharacterizing the morphology of suburban settlements: a method based on a semi-automatic classification of building clusters
de Smet, Fabian; Teller, Jacques ULg

in Landscape Research (2015)

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of ... [more ▼]

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of much debate amongst scientists. The present article takes the view that, beyond measuring and delineating suburban areas, more efforts should be directed to qualifying the morphology of built settlements within these areas. Therefore it proposes a method based on a semi-automatic classification system of building clusters, designed to describe and interpret the phenomenon from a morphological perspective. This method is based on a combination of field surveys with numerical analyses of digital land cadastre maps. The application of this classification system to the suburban area around Liege reveals that, far from developing in a complete indifference of local conditions, contemporary suburban settlements are influenced by landscape structures inherited from the past. [less ▲]

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See detailA semiquantitative framework for gene regulatory networks: increasing the time and quantitative resolution of Boolean networks
Kerkhofs, Johan ULg; Geris, Liesbet ULg

in PLoS ONE (2015), 10(6), 0130033

Boolean models have been instrumental in predicting general features of gene networks and more recently also as explorative tools in specific biological applications. In this study we introduce a basic ... [more ▼]

Boolean models have been instrumental in predicting general features of gene networks and more recently also as explorative tools in specific biological applications. In this study we introduce a basic quantitative and a limited time resolution to a discrete (Boolean) framework. Quantitative resolution is improved through the employ of normalized variables in unison with an additive approach. Increased time resolution stems from the introduction of two distinct priority classes. Through the implementation of a previously published chondrocyte network and T helper cell network, we show that this addition of quantitative and time resolution broadens the scope of biological behaviour that can be captured by the models. Specifically, the quantitative resolution readily allows models to discern qualitative differences in dosage response to growth factors. The limited time resolution, in turn, can influence the reachability of attractors, delineating the likely long term system behaviour. Importantly, the information required for implementation of these features, such as the nature of an interaction, is typically obtainable from the literature. Nonetheless, a trade-off is always present between additional computational cost of this approach and the likelihood of extending the model’s scope. Indeed, in some cases the inclusion of these features does not yield additional insight. This framework, incorporating increased and readily available time and semi-quantitative resolution, can help in substantiating the litmus test of dynamics for gene networks, firstly by excluding unlikely dynamics and secondly by refining falsifiable predictions on qualitative behaviour. [less ▲]

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See detailFluorinated alcohols as activators for the solvent-free chemical fixation of carbon dioxide onto epoxides
Gennen, Sandro ULg; Alves, Margot ULg; Méreau, Raphaël et al

in ChemSusChem (2015), 8(11), 1845-1849

The addition of fluorinated alcohols to onium salts provides highly efficient organocatalysts for the chemical fixation of CO2 onto epoxides under mild experimental conditions. The combination of online ... [more ▼]

The addition of fluorinated alcohols to onium salts provides highly efficient organocatalysts for the chemical fixation of CO2 onto epoxides under mild experimental conditions. The combination of online kinetic studies, NMR titrations and DFT calculations allows understanding this synergistic effect that provides an active organocatalyst for CO2/epoxides coupling. [less ▲]

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See detailA new design of organic radical batteries (ORBs): carbon nanotube buckypaper electrode functionalized by electrografting
Aqil, Abdelhafid ULg; Vlad, Alexandru; Piedboeuf, Marie-Laure ULg et al

in Chemical Communications (2015), 51(45), 9301-9304

A novel hybridmaterial displaying a fast and reversible charge storage capability is prepared by electrografting of an alkoxyamine-bearing acrylate onto a carbon nanotube buckypaper, followed by the quan ... [more ▼]

A novel hybridmaterial displaying a fast and reversible charge storage capability is prepared by electrografting of an alkoxyamine-bearing acrylate onto a carbon nanotube buckypaper, followed by the quan- titative generation of an electroactive polynitroxide. [less ▲]

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See detailGlobal parasite and Rattus rodent invasions: The consequences for rodent-borne diseases
Morand, Serge; Bordes, Frédéric; Chen, Hsuan-Wien et al

in Integrative Zoology (2015)

We summarize the current knowledge on parasitism-related invasion processes of the globally invasive Rattus lineages, originating from Asia, and how these invasions have impacted the local epidemiology of ... [more ▼]

We summarize the current knowledge on parasitism-related invasion processes of the globally invasive Rattus lineages, originating from Asia, and how these invasions have impacted the local epidemiology of rodent-borne diseases. Parasites play an important role in the invasion processes and successes of their hosts through multiple biological mechanisms such as "parasite release", "immunocompetence advantage", “biotic resistance” and "novel weapon". Parasites may also greatly increase the impact of invasions by spillover of parasites and other pathogens, introduced with invasive hosts, into new hosts potentially leading to novel emerging diseases. Another potential impact is the ability of the invader to amplify local parasites by spill-back. In both cases, local fauna and humans may be exposed to new health risks, which may decrease biodiversity and may potentially cause increases in human morbidity and mortality. Here we review the current knowledge on these processes and propose some research priorities. [less ▲]

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See detailThe physics of badminton
Cohen, Caroline; Darbois-Texier, Baptiste ULg; Quéré, David et al

in New Journal of Physics (2015), 17

The conical shape of a shuttlecock allows it to flip on impact. As a light and extended particle, it flies with a pure drag trajectory.We first study the flip phenomenon and the dynamics of the flight and ... [more ▼]

The conical shape of a shuttlecock allows it to flip on impact. As a light and extended particle, it flies with a pure drag trajectory.We first study the flip phenomenon and the dynamics of the flight and then discuss the implications on the game. Lastly, a possible classification of different shots is proposed. [less ▲]

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See detailEffects of Holothuroid Ichtyotoxic Saponins on the Gills of Free-Living Fishes and Symbiotic Pearlfishes
Eeckhaut, Igor; Caulier, Guillaume; Brasseur, Lola et al

in The Biological Bulletin (2015), 228(3), 253-265

Several carapid fishes, known as pearlfishes, are endosymbiotic in holothuroids and asteroids. These echinoderms contain a strong concentration of saponins that are efficient membranolytic repellents to ... [more ▼]

Several carapid fishes, known as pearlfishes, are endosymbiotic in holothuroids and asteroids. These echinoderms contain a strong concentration of saponins that are efficient membranolytic repellents to predators. We compared the effects of exposure to saponins from the sea cucumber body wall and from the Cuvierian tubules on the behavior and gill ultrastructure of pearlfishes and free-living fishes. Saponins were extracted from the body wall of two holothuroids, the Mediterranean Holothuria forskali and the tropical Bohadschia atra, and from the water surrounding the Cuvierian tubules of B. atra. Five species of carapids that live in symbiosis with holothuroids and seven species of free-living fishes were exposed to these extracts. The free-living fishes exhibited a stress response and died about 45 times faster than pearlfishes when exposed to the same quantity of saponins. Cuvierian tubules and saponins extracted from the body wall were lethal to the free-living fishes, whereas the carapids were much less sensitive. The carapids did not exhibit a stress response. The high toxicity shown by Cuvierian tubules was not explained by the nature of the saponins that were identified by mass spectrometry, but it is likely due to the higher concentration of saponins in the tubules. Histology and scanning and transmission electron microscopy of the gills of the free-living fishes and pearlfishes showed that saponins act at the level of the secondary lamellae where they induce the detachment of the epithelia, create edema at the level of the epithelia, and induce pores in the epithelial cells that lead to their destruction and the invasion of inner cells (pillar cells and red blood cells). This sequence of events happens 5 min after saponin exposure in free-living fishes and after 1 h in carapids. [less ▲]

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See detailThe nonlinear piezoelectric tuned vibration absorber
Soltani, Payam ULg; Kerschen, Gaëtan ULg

in Smart Materials and Structures (2015), 24(07), 075015

This paper proposes a piezoelectric vibration absorber, termed the nonlinear piezoelectric tuned vibration absorber (NPTVA), for the mitigation of nonlinear resonances of mechanical systems. The new ... [more ▼]

This paper proposes a piezoelectric vibration absorber, termed the nonlinear piezoelectric tuned vibration absorber (NPTVA), for the mitigation of nonlinear resonances of mechanical systems. The new feature of the NPTVA is that its nonlinear restoring force is designed according to a principle of similarity, i.e., the NPTVA should be an electrical analog of the nonlinear host system. Analytical formulas for the NPTVA parameters are derived using the homotopy perturbation method. Doing so, a nonlinear generalization of Den Hartog’s equal-peak tuning rule is developed for piezoelectric vibration absorbers. [less ▲]

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See detailNovel nanosized water soluble fluorescent micelles with embedded perylene diimide fluorophores for potential biomedical applications: Cell permeability, localization and cytotoxicity
Bryaskova, Rayna; Georgiev, Nikolai I.; Dimov, Stefan M. et al

in Materials Science & Engineering : C (2015), 51

Novel biocompatiblewater-soluble fluorescent micelleswithembedded perylene diimides (PDI) for intracellular applications have been prepared by self assembling of amphiphilic poly(vinyl alcohol)-b-poly ... [more ▼]

Novel biocompatiblewater-soluble fluorescent micelleswithembedded perylene diimides (PDI) for intracellular applications have been prepared by self assembling of amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVA-b-PAN) copolymers in the presence of synthesized fluorophores. Amphiphilic PVA-b-PAN copolymers were obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) (PVAc-b-PAN) copolymer. The preparation of the novel fluorescence micelles consisting of PVA hydrophilic shell and PAN hy- drophobic core with incorporated PDI fluorophores has been confirmed by DLS and TEManalysis. The cytotoxic- ity of the water-soluble fluorophores and their internalization into living cells depending on the micellar concentration have been tested. Itwas shown that they could successfully enter in living cellswithout destroying their morphology. The results obtained indicate that the novel water-soluble fluorescent micelles with embed- ded PDI fluorophores would be suitable for potential intracellular biomedical applications. [less ▲]

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See detailLe dosage du cobalt dans le sang par ICP-MS : application aux patients porteurs de prothèses de hanche en métal
MISTRETTA, Virginie ULg; Charlier, Corinne ULg

in Toxicologie Analytique & Clinique (2015), 27(2), 91-98

Objectif Les patients porteurs de prothèse de hanche à couple métal-métal (PHM) présentent un taux de cobalt circulant supérieur à celui de la population générale. Chez ces patients, le dosage du cobalt ... [more ▼]

Objectif Les patients porteurs de prothèse de hanche à couple métal-métal (PHM) présentent un taux de cobalt circulant supérieur à celui de la population générale. Chez ces patients, le dosage du cobalt permet d’apprécier le risque toxique éventuel de l’implant et peut servir d’indicateur de révision ou de remplacement de cette prothèse. A cette fin, une méthode de dosage a été validée et appliquée à des patients porteurs de PHM. Méthode Le dosage du cobalt est réalisé sur 500 μL de sang total, après dilution dix fois dans une solution aqueuse acide et après ajout de 100 μL d’une solution de standard interne titrée à 500 μg/L de germanium. L’échantillon est ensuite analysé par un spectromètre de masse avec source d’ionisation par plasma induit haute fréquence (ICP-MS). La méthode décrite a été validée par l’approche de l’erreur totale au moyen du logiciel e•noval (Arlenda®). Résultats La méthode de dosage a été validée avec succès. Elle est linéaire de 0,5 à 50 μg/L. L’inexactitude et l’imprécision intra- et inter-essais sont inférieures à 5 % et 8 %, respectivement. L’incertitude de mesure est inférieure à 17 %. La concentration sanguine moyenne de cobalt estimée sur une période de 1 an à partir de 107 prélèvements de patients porteurs de PHM est de 2,61 μg/L (nombre de patients : 98 ; âge moyen : 60 ans ; ratio hommes/femmes : 38/60). Ce résultat est inférieur au seuil recommandé dans ces populations, fixé à 7 μg/L de cobalt sanguin. Conclusion La méthode analytique présentée permet de doser le cobalt sanguin, notamment chez les patients porteurs de PHM. Ce dosage est recommandé pour le suivi de ces patients, en association avec un examen clinique et radiologique. [less ▲]

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See detailTriiodothyronine-predominant Graves’ disease in childhood: detection and therapeutic implications
HARVENGT, Julie ULg; boizeau, priscilla; chevenne, didier et al

in European Journal of Endocrinology (2015), 172(6), 715-723

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See detailThe Authority of Strasbourg Jurisprudence from the Perspective of the International Criminal Court
Deprez, Christophe ULg

in Journal Européen des Droits de l'Homme = European Journal of Human Rights (2015), 3

Although the case law of the European Court of Human Rights (Eur. Ct. H.R.) exerts a critical influence on the development of the practice of the International Criminal Court (ICC), it remains unclear ... [more ▼]

Although the case law of the European Court of Human Rights (Eur. Ct. H.R.) exerts a critical influence on the development of the practice of the International Criminal Court (ICC), it remains unclear what the exact authority of such external jurisprudence is vis-à-vis the international criminal judge. This article addresses the question whether ICC judges have used Strasbourg jurisprudence in a consistent manner, in particular as regards the authority which they decided to vest the latter with. It demonstrates that the Court’s chambers have relied on European human rights practice, alternatively, as a mere source of inspiration, as binding interpretation, as a corpus having ambivalent authority, or as a source whose value it simply left unspecified. It therefore concludes that the ICC has been mostly inconsistent regarding the authority of the case law of the Eur. Ct. H.R. in the context of international criminal proceedings. Such inconsistency, it is argued, amounts to a discretionary use of Strasbourg jurisprudence that further reinforces the ICC’s paradoxical position as the ultimate authority for defining the boundaries of its own human rights constraint. [less ▲]

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See detailPrevenção quaternária: primeiro não causar dano - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-3

A prevenção clínica, sob a influência da saúde pública, foi organizada de forma cronológica, desde meados do século XX. No entanto, uma mudança de paradigma de uma ordem cronológica para um padrão ... [more ▼]

A prevenção clínica, sob a influência da saúde pública, foi organizada de forma cronológica, desde meados do século XX. No entanto, uma mudança de paradigma de uma ordem cronológica para um padrão construtivista fundamentado em uma relação preventiva de atendimento, oferece novas,reflexões à prática dos médicos. Essa mudança de paradigma traz à tona o conceito de prevenção quaternária, um olhar crítico sobre as atividades médicas, com ênfase na necessidade de não causar danos. A prevenção quaternária aborda a questão principal do que se constitui como ‘muita’ ou ‘pouca’ medicina. Ela é a quarta forma de prevenção de doenças, e também a quarta etapa de ação dos médicos de família [less ▲]

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See detailLa remise en question du droit international public. La charge critique du juriste Albéric Rolin (1918-1920)
Genin, Vincent ULg

in Bulletin d'Information du Centre Liégeois d'Histoire et d'Archéologie Militaires (2015), 138

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See detailDe la périménopause à la ménopause, quel intérêt d'un examen biologique
BELIARD, Aude ULg

in Revue de Médecine Générale (2015), 324

Do hormonal blood tests provide support to the management of perimenopause? Should there be a systematic biological assessment before initiating hormonal therapy and to help monitoring it?

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See detailFrom the Guiding Principles on Internal Displacement to the Nansen Initiative: What the Governance of Environmental Migration Can Learn from the Governance of Internal Displacement
Gemenne, François ULg; Brücker, Pauline

in International Journal of Refugee Law (2015), 27(2), 245-263

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the ... [more ▼]

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the protection of these migrants is not adequately addressed in the international normative frameworks on migration. As a result, a growing number of scholars and advocacy groups have sought to create a special convention and/or an ad hoc status for these migrants, while others have contended that such a legal status is not the answer. As a result, the protection of environmental migrants is currently the subject of vigorous debates amongst scholars and policy-makers, and no clear solution is yet in sight. Research however has little considered the debates that surrounded the protection of those displaced within their countries (IDPs) in the 1990s. Both phenomena have sometimes overlapped, especially as environmental displacement is often internal. Yet, the debate on IDPs has had some significant success, in particular, the adoption of the Guiding Principles on Internal Displacement in 1998, and the signature of the Organization for African Unity’s Kampala Convention in 2009. This article argues that important lessons can be drawn from the protection of IDPs in order to inform the current debates on the protection of environmental migrants, as the political contexts and policy challenges associated with both crises of the migration regime are often similar. The article identifies such lessons and assesses the opportunities and caveats of applying a similar approach of soft law to environmental migration – and what would be needed to achieve it. [less ▲]

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See detailThe Herschel view of the nebula around the luminous blue variable star AG Carinae
Vamvatira-Nakou, Chloi ULg; Hutsemekers, Damien ULg; Royer, P. et al

in Astronomy and Astrophysics (2015), 578

Far-infrared Herschel PACS imaging and spectroscopic observations of the nebula around the luminous blue variable (LBV) star AG Car have been obtained along with optical imaging in the Halpha+[NII] filter ... [more ▼]

Far-infrared Herschel PACS imaging and spectroscopic observations of the nebula around the luminous blue variable (LBV) star AG Car have been obtained along with optical imaging in the Halpha+[NII] filter. In the infrared light, the nebula appears as a clumpy ring shell that extends up to 1.2 pc with an inner radius of 0.4 pc. It coincides with the Halpha nebula, but extends further out. Dust modeling of the nebula was performed and indicates the presence of large grains. The dust mass is estimated to be ~ 0.2 Msun. The infrared spectrum of the nebula consists of forbidden emission lines over a dust continuum. Apart from ionized gas, these lines also indicate the existence of neutral gas in a photodissociation region that surrounds the ionized region. The abundance ratios point towards enrichment by processed material. The total mass of the nebula ejected from the central star amounts to ~ 15 Msun, assuming a dust-to-gas ratio typical of LBVs. The abundances and the mass-loss rate were used to constrain the evolutionary path of the central star and the epoch at which the nebula was ejected, with the help of available evolutionary models. This suggests an ejection during a cool LBV phase for a star of ~ 55 Msun with little rotation. [less ▲]

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See detailDefensins: « simple » antimicrobial peptides or broad-spectrum molecules ?
Suarez-Carmona, Meggy ULg; Hubert, Pascale ULg; Delvenne, Philippe ULg et al

in Cytokine & Growth Factor Reviews (2015), 26

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See detailExtended end-plate to concrete- filled rectangular column joint using long bolts
Hoang, Van Long ULg; Jaspart, Jean-Pierre ULg; Demonceau, Jean-François ULg

in Journal of Constructional Steel Research (2015), 113

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See detailFor a Critical Iconology : the Meaning, Dynamics and Effectiveness of Images
Hagelstein, Maud ULg

in Critique d'Art : Actualité Francophone et Internationale de la Littérature Critique sur l'Art Contemporain = The International Review of Contemporary Art Criticism (2015)

The present-day theory of image comes in the wake of iconology, by virtue of the explicit re-use of several problematic themes which are central to this method, and permit its critical redevelopment : 1 ... [more ▼]

The present-day theory of image comes in the wake of iconology, by virtue of the explicit re-use of several problematic themes which are central to this method, and permit its critical redevelopment : 1. Reflection about iconic representation, about its relation to language and its specific logic; 2. The investigation into the dynamics of the image (circulation, persistence and development); 3. The study of the effectiveness of images and the production of many different kinds ok knowledge under the effect of editing operations. [less ▲]

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See detailPanorama des incitants fiscaux destinés à stimuler l’investissement privé dans le secteur cinématographique
Vandenbulke, Antoine ULg

in Agefi Luxembourg (2015)

The film industry in Europe is largely funded through States support mechanisms. Among the many instruments set up by the various national laws, particular attention should be given to tax incentives ... [more ▼]

The film industry in Europe is largely funded through States support mechanisms. Among the many instruments set up by the various national laws, particular attention should be given to tax incentives aimed to stimulate private capital investments in this sector particularly risky. This short paper aims to outline the main features of tax breaks for the private financing of an audiovisual work in three States in particular: France, Belgium and Luxembourg. [less ▲]

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See detailLa Belgique, un pays ‘neutre’ ou un ‘petit pays’ ? La controverse autour du maintien de la neutralité imposée de la Belgique (1914-1919)
Genin, Vincent ULg

in Bulletin d'Information du Centre Liégeois d'Histoire et d'Archéologie Militaires (2015), 138

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See detailThe International Journal of Learning in Higher Education
Noiroux, Kevin ULg

in International Journal of Learning in Higher Education (2015), 22

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See detailL’indication comme concept. La logique des « groupes althussériens » (1965-1968)
Mancuso, Eva ULg

in Cahiers du GRM (2015), VII

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See detailPharmacokinetics and clinical evaluation of the alogliptin plus pioglitazone combination for type 2 diabetes.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2015), 11(6), 1005-20

INTRODUCTION: Type 2 diabetes is a complex disease with multiple defects, which generally requires a combination of several pharmacological approaches to reach glucose control targets. A unique fixed-dose ... [more ▼]

INTRODUCTION: Type 2 diabetes is a complex disease with multiple defects, which generally requires a combination of several pharmacological approaches to reach glucose control targets. A unique fixed-dose combination combines a thiazolidinedione (pioglitazone) and a dipeptidyl peptidase-4 inhibitor (alogliptin). Area covered: An extensive literature search was performed to analyze the pharmacokinetics of pioglitazone and alogliptin when used separately and in combination as well as to summarize clinical and toxicological considerations about the combined therapy. Expert opinion: Pioglitazone, a potent insulin sensitizer, and alogliptin, an incretin-based agent that potentiates post-meal insulin secretion and reduces glucagon secretion, have complementary mechanisms of action. The clinical efficacy of a combined therapy is superior to any single therapy in patients treated with diet or with metformin (with or without sulphonylurea). These two drugs can be administered once daily, with or without a meal. No clinically relevant pharmacokinetic interactions between the two agents have been described and the fixed-dose combination has shown bioequivalence with alogliptin and pioglitazone given separately. Combining alogliptin with pioglitazone does not alter the safety profile of each compound. Weight gain observed with pioglitazone may be limited with the addition of alogliptin. The concern of an increased risk of heart failure remains to be better investigated. [less ▲]

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See detailInvestigation of Demagnetization in HTS Stacked Tapes Implemented in Electric Machines as a Result of Crossed Magnetic Field
Baghdadi, M.; Ruiz, H. S.; Fagnard, Jean-François ULg et al

in IEEE Transactions on Applied Superconductivity (2015), 25(3), 6602404

This paper investigates the practical effectiveness of employing superconducting stacked tapes to superconducting electric machinery. The use of superconducting bulks in various practical applications has ... [more ▼]

This paper investigates the practical effectiveness of employing superconducting stacked tapes to superconducting electric machinery. The use of superconducting bulks in various practical applications has been addressed extensively in the literature. However, in practice, dramatic decrease in magnetization would occur on superconducting bulks due to the crossed field effect. In our study, we employed the superconducting stacked tapes in a synchronous superconducting motor, which was designed and fabricated in our laboratory, aiming to lessen demagnetization due to crossed field effect in comparison with superconducting bulks. Applying the transverse AC field, the effects of frequency, amplitude, and number of cycles of the transverse magnetic field are discussed. Furthermore, a stack of 16 layers of superconducting tapes is modelled and the consequences of applying the crossed magnetic field on the sample are evaluated. The confrontation between experiments and simulation allows us to thoroughly understand the crossed field effects on stacked tapes. At the end, a preventive treatment, based on the shielding characteristic of superconductor and materials with high permeability, i.e. $mu$-metal and metalic glass, is suggested. On the other hand, the shielding feature of aforementioned materials will hinder the penetration of magnetic field and, consequently, reduction of the demagnetization will be attained. [less ▲]

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