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See detailArrêts sur images – usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un ... [more ▼]

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un défilement réglé (24 photogrammes/seconde) par le dispositif technique du cinéma. Image paradoxale en ce qu’elle reste invisible au spectateur malgré sa force iconique, le photogramme trouve cependant, dans le flux qui le conduit insensiblement à la disparition, certaines zones de visibilité qui en révèlent le caractère à la fois fragile et intensif. Nous allons donc envisager certaines pratiques ou certains usages du photogramme cinématographique, tout en essayant de dégager, au départ de ces pratiques, les éléments d’une théorie du photogramme, que Roland Barthes et Sylvie Pierre appelaient déjà de leurs vœux. Des protos-photogrammes et de leur usage scientifique chez Muybridge et Marey, aux usages artistiques contemporains, en passant par des pratiques publicitaires, promotionnelles ou analytiques, nous allons voir que le photogramme reste un objet singulier. [less ▲]

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See detailCoordinated Supervisory Control of Multi-Terminal HVDC Grids: a Model Predictive Control Approach
Papangelis, Lampros ULg; Debry, Marie-Sophie; Panciatici, Patrick et al

in IEEE Transactions on Power Systems (in press)

A coordinated supervisory control scheme for future multi-terminal High-Voltage Direct-Current (HVDC) grids is proposed. The purpose is to supervise the grid and take appropriate actions to ensure power ... [more ▼]

A coordinated supervisory control scheme for future multi-terminal High-Voltage Direct-Current (HVDC) grids is proposed. The purpose is to supervise the grid and take appropriate actions to ensure power balance and prevent or remove voltage or current limit violations. First, using DC current and voltage measurements, the power references of the various Voltage Sources Converters (VSC) are updated according to participation factors. Next, the setpoints of the converters are smoothly adjusted to track those power references, while avoiding or correcting limit violations. The latter function resorts to Model Predictive Control and a sensitivity model of the system. The efficiency of the proposed scheme has been tested through dynamic simulations of a five-terminal HVDC grid interconnecting two asynchronous AC areas and a wind farm. [less ▲]

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See detailLevallois et Gravettien
Otte, Marcel ULg; Noiret, Pierre ULg

in Praehistoria (in press)

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein ... [more ▼]

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein du Gravettien touchent autant les processus de symbolisation dans l’art et les sépultures. Elles affectent différents substrats eurasiatiques, plutôt septentrionaux, comme mis en réserve dès les Néandertaliens. [less ▲]

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See detailCompte-rendu de l'ouvrage de Boyd Taylor COOLMAN et Dale M. COULTER : Trinity and creation
Close, Florence ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailOutcome after failure of allogeneic hematopoietic stem cell transplantation in children with acute leukemia: a study by the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Rorhlich; Roux, C; Tifratene, K et al

in Bone Marrow Transplantation (in press)

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation relapse. We aimed to compare treatment strategies in 334 consecutive children with acute leukemia relapse or progression after SCT in a recent ten-year period. Data could be analyzed in 288 patients (157 ALL, 123 AML and 8 biphenotypic AL) with a median age of 8.16 years at transplantation. The median delay from first SCT to relapse or progression was 182 days. The treatment consisted in chemotherapy alone (n=108), chemotherapy followed by second SCT (n=70), supportive/palliative care (n=67), combination of chemotherapy and DLI (n=30), or isolated reinfusion of donor lymphocytes (DLI) (n=13). The median OS duration after relapse was 164 days and differed according to therapy: DLI after chemotherapy = 385 d, second allograft = 391d, chemotherapy = 174d, DLI alone = 140d, palliative care = 43d. A second SCT or a combination of chemotherapy and donor lymphocytes infusion yielded similar outcome (HR=0.85, p=0.53) unlike chemotherapy alone (HR 1.43 p=0.04), palliative care (HR=4.24, p<0.0001) or isolated DLI (HR=1,94, p<0.04). Despite limitations in this retrospective setting, strategies including immunointervention appear superior to other approaches, mostly in AML. [less ▲]

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See detailEpistémologie de la théorie du complot
Jamin, Jérôme ULg

in Cahiers de l'Éducation Permanente (Les) (in press)

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See detailComparative assessment of 6-[18F]fluoro-L-m-tyrosine and 6-[18F]fluoro-L-dopa to evaluate dopaminergic presynaptic integrity in a Parkinson’s disease rat model.
Becker, Guillaume ULg; Bahri, Mohamed Ali ULg; Michel, Anne et al

in Journal of Neurochemistry (in press)

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical ... [more ▼]

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the pre-clinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [18F]fluoro-3,4-dihydroxyphenyl-L-alanine ([18F]FDOPA) and 6-[18F]fluoro-L-m-tyrosine ([18F]FMT). Because the imaging signal is theoretically less contaminated by metabolites, we hypothesized that the latter would show stronger relationship with behavioural and post-mortem measures of striatal dopaminergic deficiency. We used a within-subject design to measure striatal [18F]FMT and [18F]FDOPA uptake in eight partially lesioned, eight fully lesioned and ten sham-treated rats. Animals were pretreated with an L-aromatic amino acid decarboxylase (AADC) inhibitor. A catechol-O-methyl transferase inhibitor was also given before [18F]FDOPA PET. Quantitative estimates of striatal uptake were computed using conventional graphical Patlak method. Striatal dopaminergic deficiencies were measured with apomorphine-induced rotations and post-mortem striatal DA content. We observed a strong relationship between [18F]FMT and [18F]FDOPA estimates of decreased uptake in the denervated striatum using the tissue-derived uptake rate constant Kc. However, only [18F]FMT Kc succeeded to discriminate between the partial and the full 6-OHDA lesion and correlated well with the post-mortem striatal DA content. This study indicates that the [18F]FMT could be more sensitive, with respect of [18F]FDOPA, to investigate DA terminals loss in 6-OHDA rats, and open the way to in vivo AADC activity targeting in future investigations on progressive PD models. [less ▲]

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See detailThe right dorsal premotor mosaic: organization, functions, and connectivity
Genon, Sarah ULg; Li, Hai; Fan, Lingzhong et al

in Cerebral Cortex (in press)

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a ... [more ▼]

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our CBP results to parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography,. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into five distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found (i) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory (ii) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and (iii) a caudal subregion closely integrated with the motor system. Additionally, we found (iv) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and (v) a ventral subregion, whose functional profile fits the concept of an eye-movement related field. In conclusion, right PMd may be considered as a functional mosaic formed by five subregions. [less ▲]

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See detailNote a Jacopino del Conte e approfondimenti sulla sua attività giovanile
Geremicca, Antonio ULg

in Proporzioni. Annali della Fondazione Roberto Longhi (in press)

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See detailTechnological behaviour of Cretaceous and Pliocene clays of northern Morocco used in fired brick manufacturing
El Ouahabi, Meriam ULg; Daoudi, Lahcen; Fagel, Nathalie ULg

in Journal of Materials and Environmental Science (in press)

Northern Morocco has an important local ceramic industry. Twenty-three Craterous and Pliocene clays from Tangier area (Northern Morocco) were studied to test their suitability as raw material for fired ... [more ▼]

Northern Morocco has an important local ceramic industry. Twenty-three Craterous and Pliocene clays from Tangier area (Northern Morocco) were studied to test their suitability as raw material for fired brick production. To assess their behaviour, the chemical composition, specific surface area (SSA), cation exchange capacity (CEC), and apparent density of clays were determined. The chemical composition consisted mainly of SiO2 (32 – 60%), Al2O3 (7 – 30%), and CaO (0.5 – 32%). SSA and CEC values of all the samples were low. The apparent density, pore volume, and micropore values were almost similar. Clay bricks were prepared by forming and shaping, and then fired in the range of 800 – 1100°C. Firing shrinkage, loss on mass and water absorption capacity were done in order to characterize clays after firing. Most of the clay samples have the necessary properties for the manufacturing of brick products. However, some clay samples were above the norm of loss on weight, due mainly to their high amount of carbonates. Furthermore, some kaolinitic samples from Pliocene blue marls and Cretaceous marls are inappropriate for building-related brick fabrication, because of the development of portlandite in brick, when in contact with moisture of the air. However, it will be necessary to mix them with other clays with little or no carbonate to dilute their carbonates content and then enhance their workability. [less ▲]

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See detailResurgence of Schmallenberg virus in Belgium after 3 years of epidemiological silence
Delooz, L; Saegerman, Claude ULg; Quinet, C et al

in Transboundary and Emerging Diseases (in press)

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See detailTestosterone-induced neuroendocrine changes in the medial preoptic area precede song activation and plasticity in song control nuclei of female canaries
Shevchouk, Olesya ULg; Ghorbanpoor, Samar; Ball, Gregory F et al

in European Journal of Neuroscience (in press)

Testosterone plays a key role in the control of seasonal changes in singing behavior and its underlying neural circuitry. After administration of exogenous testosterone, song quality and song control ... [more ▼]

Testosterone plays a key role in the control of seasonal changes in singing behavior and its underlying neural circuitry. After administration of exogenous testosterone, song quality and song control nuclei volumes change over the course of weeks, but song rate increases within days. The medial preoptic nucleus (POM) controls sexual motivation and testosterone action in POM increases sexually motivated singing. Here, we investigated the time course of testosterone action in the song control nuclei and POM, at the gross anatomical and cellular level. Photosensitive female canaries were injected with BrdU to label newborn neurons. One day later they were transferred to a long day photoperiod and implanted with testosterone-filled or empty implants. Brains and blood were collected 1, 2, 9 or 21 days later. Testosterone increased POM volume within one day, whereas the volume of song control nuclei increased significantly only on day 21 even if a trend was already observed for HVC on day 9. The density of newborn neurons in HVC, labeled by Bromodeoxyuridine (BrdU) and doublecortin, was increased by testosterone on days 9 and 21 although a trend was already detectable on day 2. In POM testosterone increased the number and size of aromatase-immunoreactive neurons already after one day. This rapid action of testosterone in POM supports its proposed role in controlling singing motivation. Although testosterone increased the number of newborn neurons in HVC rapidly (9, possibly 2 days), it is unlikely that these new neurons affect singing behavior before they mature and integrate into functional circuits. [less ▲]

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See detailUne vision moderne de la dépression et de son hétérogénéité
Wagener, Aurélie ULg; Blairy, Sylvie ULg

in Revue Francophone de Clinique Comportementale et Cognitive (in press)

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See detailEvolution and diversity of ram-suction feeding in damselfishes (Pomacentridae)
Olivier, Damien ULg; Gajdzik, Laura ULg; Parmentier, Eric ULg et al

in Organisms Diversity & Evolution (in press)

The cerato-mandibular (c-md) ligament is a synapomorphy within Pomacentridae that creates a tight link between the lower jaws and the hyoid bars. However, this morphological trait has been secondarily ... [more ▼]

The cerato-mandibular (c-md) ligament is a synapomorphy within Pomacentridae that creates a tight link between the lower jaws and the hyoid bars. However, this morphological trait has been secondarily lost in multiple lineages during evolution. A previous study revealed that the loss of this trait acted as a release of evolutionary constraints, leading to a cascade of morphological changes such elongated buccal jaws and a slender body. Ecomorphological interpretations suggested the loss of the c-md ligament has ultimately led to a new adaptive peak in zooplanktivory through an optimization of the ram feeding mode associated with a specialization in pelagic feeding. Here, we tested these hypotheses by comparing functional and diet diversity between damselfish species with and without the c-md ligament. Although species lacking the c-md ligament presented a conserved kinematic pattern resulting from high ram and low suction performances, our results did not support an optimization of the ram feeding mode. Indeed, some species with the c-md ligament showed the same or exceeded the ram performance of species without the c-md ligament. The species with the c-md ligament had a more diverse kinematic pattern exploring the entire ram-suction functional range in damselfishes. Finally, our results did not show any diet variations associated with the loss of the c-md ligament. Our study furthers the understanding of how a morphological trait has shaped, by its presence or absence, the ecomorpho-functional diversification of Pomacentridae. [less ▲]

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See detail"'Vive la rose' in Newfoundland: from Alien to Emblem'
Peere, Isabelle ULg

in B.A.S.I.S International Ballad Studies (in press)

This paper traces the song in European tradition through to its ‘revival’ in the 1960s. It analyses Emile’ Benoît's textual and musical recreation of it in the light of my own and other fieldworkers’ ... [more ▼]

This paper traces the song in European tradition through to its ‘revival’ in the 1960s. It analyses Emile’ Benoît's textual and musical recreation of it in the light of my own and other fieldworkers’ accounts of his personality, ethos and creative talent in tradition. The study traces the song's course and progress in Newfoundland, following in the steps of French-Canadian ethno-historian Ronald Labelle’s suggestion that ‘Vive la Rose’ has come to function as identity emblem for Newfoundland’s francophone minority – and even as its representative throughout French-Canada and especially Acadia. [less ▲]

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See detailA component method for cold-formed steel beam-to-column bolted gusset plate joints
Bucmys, Zilvinas; Daniunas, Alfonsas; Jaspart, Jean-Pierre ULg et al

in Thin-Walled Structures (in press)

Cold-formed steel elements are being used more frequently on construction sites because of the good strength-to-cost ratio. However, insufficient studies are published examining the properties of these ... [more ▼]

Cold-formed steel elements are being used more frequently on construction sites because of the good strength-to-cost ratio. However, insufficient studies are published examining the properties of these constructions. This paper presents a study of cold formed steel bolted gusset plate connections. A “three springs” mechanical model to calculate joint stiffness is presented. Then the results predicted through the proposed model are validated through comparisons to experimental and finite element results. [less ▲]

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See detailSpecies delimitation in the recalcitrant moss genus Rhynchostegiella (Brachytheciaceae)
Patiño, J.; Hedenäs, L.; Dirkse, G. et al

in Taxon (in press)

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See detailGoat breeding in the rural district of Chemini (Algeria)
Moula, Nassim ULg; Ait Kaki, Asma; Touazi, Leghel et al

in Nature & Technology (in press)

The Kabyle goat breed represents 10.52% of the total Algerian market (3.8 million heads). A survey of 69 farmers has been carried out in order to characterize it and its breeding in the District of ... [more ▼]

The Kabyle goat breed represents 10.52% of the total Algerian market (3.8 million heads). A survey of 69 farmers has been carried out in order to characterize it and its breeding in the District of Chemini. The questions focused on household agricultural activities, including breeding of goats, cattle, sheep, rabbits, chicken, turkeys, honeybees and the production of olive oil and figs. The goat morpho-biometric characterization was based on 18 corporal measurements. The Hierarchical Cluster Analysis (HCA) of the farm structures defined four groups of farms, variance between groups accounting for 55.7% of total variability. The average number of goats in groups 1 to 4 was 7.2±2.8, 11.1±3.5, 22.3±1.4 and 3.4±1.0, respectively. Group 3 (n=6), showed the greatest number; it consists of older farmers (67 years old or over) not practicing arboriculture. They also have the largest numbers of sheep (48.67), rabbits (50.83), chicken (48.33) and turkeys (42). Group 4 (n=9), with the lowest number of goats, was the group of young farmers (39 years old or less), more dedicated to cattle breeding (~52 heads) and the production of olive oil (~207 trees) and figs (~47 trees). The 18 morpho-biometric variables were significantly higher in males than in females (p<0.05). The Kabyle goat is small (Height at withers: male: 68.23±0.97cm and female: 65.41±0.55cm) with long hair (male: 12.24±0.51cm, and female: 9.51±0.29cm). Its ears are drooping, its convex profile has a slightly pronounced nasal split and its dress color ranges from dark brown to black. This adapted genetic resource should be key in the development of a local production, based on a strong commitment of farmers inside a breed association, for the production of specimens corresponding to a standard, to be determined collectively. [less ▲]

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See detailDistances between nested densities and a measure of the impact of the prior in Bayesian statistics
Ley, Christophe; Reinert, Gesine; Swan, Yvik ULg

in Annals of Applied Probability (in press)

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See detailGardez votre carte d'identité en poche
Bouhon, Frédéric ULg

in Revue de la Faculté de Droit de l'Université de Liège (in press), 2017/1

Dans cette brève contribution, nous abordons la question de l'utilisation de la carte d'identité en Begique et les problèmes que cela soulève en matière de gestion des données à caractère personnel. À ... [more ▼]

Dans cette brève contribution, nous abordons la question de l'utilisation de la carte d'identité en Begique et les problèmes que cela soulève en matière de gestion des données à caractère personnel. À cette fin, nous revenons d’abord sur l’obligation de porter une carte d’identité et sur les raisons d’être de ce document. Nous essayons ensuite de mesurer l’ampleur des risques qu’implique le traitement des données liées à la carte, avant de nous focaliser sur certains usages particuliers de cette dernière. [less ▲]

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See detailBeyond survival and uncertainty. The livelihood practices of former Gécamines workers (D.R.Congo)
Rubbers, Benjamin ULg

in Review of African Political Economy (in press)

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See detailPolyurethane coatings in 20th century outdoor painted sculptures. Part II: Comparative study of four systems by means of Py-GC/MS
Defeyt, Catherine ULg; Schilling, Michael; Langenbacher, Julia et al

in Heritage Science (in press)

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to ... [more ▼]

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to coat sculptures intended for an outdoor setting. However, the PU class includes various systems, such as two package solvent-borne, two package water-borne, one package water-borne and fluoropolymer polyurethanes, which possess very different properties. 115 reference samples of PU coatings were investigated by means of Py-GC/MS, in order to outline the differences and the similarities existing, in terms of composition, between the major PU systems used for creating as well as for conserving modern painted outdoor sculptures. The Py- GC/MS study of an extended number of reference samples showed that the composition of equivalent PU systems strongly varies depending on the product line and the manufacturer. Furthermore the comparison of all the produced pyrograms allowed defining characteristic marker compounds helpful to discriminate specific PU paint systems. [less ▲]

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See detailHigh-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication
Mauroy, Axel ULg; Taminiau, Bernard ULg; Nezer, Carine et al

in Archives of Virology (in press)

In this study, we report the genetic diversity and nucleotide mutation rates of five representative regions of the murine norovirus genome during in vitro passages. The mutation rates were similar in ... [more ▼]

In this study, we report the genetic diversity and nucleotide mutation rates of five representative regions of the murine norovirus genome during in vitro passages. The mutation rates were similar in genomic regions encompassing partial coding sequences for non-structural (NS) 1-2, NS5, NS6, NS7 proteins within open reading frame (ORF) 1. In a region encoding a portion of the major capsid protein (VP1) within ORF2 (also including the ORF4 region) and a portion of the minor structural protein (VP2), the mutation rates were estimated to be at least one order of magnitude higher. The VP2 coding region was found to have the highest mutation rate. [less ▲]

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See detailLa légation des Pays-Bas et de la Franche-Comté en cour de Rome sous Philippe II (1573-1598). Entre limites institutionnelles et efficacité pragmatique
Regibeau, Julien ULg

in Forum Romanum Belgicum (in press)

Dans le dernier quart du XVIe siècle, Philippe II d’Espagne est à la tête de l’ensemble territorial le plus puissant d’Europe. Fils préféré de l’Église romaine et souverain reconnu d’une grande partie de ... [more ▼]

Dans le dernier quart du XVIe siècle, Philippe II d’Espagne est à la tête de l’ensemble territorial le plus puissant d’Europe. Fils préféré de l’Église romaine et souverain reconnu d’une grande partie de l’Italie, il exerce une influence considérable sur la papauté à travers l’action de son ambassadeur espagnol résidant près le Saint-Siège. Ce dernier a pour tâche d’étendre le réseau des alliés au sein de la Curie. Il chapeaute aussi les différents services diplomatiques et ecclésiastiques des États de la monarchie présents dans la cité des papes . Si elle conserve une certaine autonomie, la légation des Pays-Bas et de la Franche-Comté près le Saint-Siège – conduite par l’agent Laurent du Blioul de 1573 à 1598 – est également soumise à la volonté de cet envoyé. Ce n’est d’ailleurs pas un hasard si l’étude de la légation à l’époque du règne de Philippe II a peu passionné les historiens . Effacée derrière la puissance de l’ambassadeur espagnol, celle-ci semble être un piètre avatar des services ecclésiastiques et diplomatiques dépêchés à Rome par les ducs de Bourgogne , Philippe le Beau ou les archiducs Albert et Isabelle . Or, si, aux temps de Laurent du Blioul, la légation, considérée en tant qu’actrice isolée dans le paysage romain, joue un rôle modeste qui se cantonne au suivi des affaires ecclésiastiques provenant des Pays-Bas et de la Franche-Comté, il faut envisager qu’elle fait partie intégrante d’une toile religieuse, diplomatique, sociale et politique plus vaste tissée à Rome par le roi Philippe II et ses agents. Dépassant les seuls intérêts des Pays-Bas, l’étude de cette institution conduit à appréhender tout un pan de la stratégie politique habsbourgeoise. L’imbrication de la légation dans le théâtre diplomatique espagnol à Rome a deux facettes : si, d’une part, elle limite les prérogatives institutionnelles de l’agent du Blioul, d’autre part, elle favorise régulièrement l’efficacité de son action. [less ▲]

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See detailChondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Sanchez, Christelle ULg; Bay-Jensen, Anne-Christine; Pap, Thomas et al

in Osteoarthritis and Cartilage (in press)

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See detailIngéniérie entre recherche et formation
Job, Pierre; Schneider-Gilot, Marguerite ULg

in Education et Didactique (in press)

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See detailAnalytical and clinical validation of the new Abbot Architect 25(OH)D assay: fit for purpose?
Cavalier, Etienne ULg; LUKAS, Pierre ULg; BEKAERT, Anne-Catherine ULg et al

in Clinical Chemistry & Laboratory Medicine (in press)

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated ... [more ▼]

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated immunoassays and against a VDSP-traceable liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in six different populations. We also supplemented 40 healthy volunteers with either 600,000 IU of vitamin D2 or 100,000 of vitamin D3 to evaluate the performance of the immunoassays vs. the LC-MS/MS. METHODS: Precision and limit of quantification were assessed, 25(OH)D2 and C3-epimer recovery were calculated. Two hundred and forty samples obtained in healthy Caucasians and Africans, osteoporotic, hemodialyzed and intensive care patients and 3rd trimester pregnant women were analyzed by all methods. Correlation was studied using Passing-Bablok and Bland-Altman analysis. Concordance correlation coefficient (CCC) was calculated to evaluate agreement between immunoassays and LC-MS/MS. We verified if patients were homogeneously classified with the immunoassays when they took vitamin D2 or vitamin D3 after 1, 7 and 28 days. RESULTS: We observed excellent analytical features and showed a very good correlation to the LC-MS/MS results in the overall population. Compared to the other immunoassays, concordance of the new Abbott assay with the LC-MS/MS was at least similar, and often better in diseased populations. Althought the cross-reactivity with 25(OH)D2 was not of 100%, there was no significant difference in the classifications of the patients, either supplemented with D2 or D3 or after 7 or 28 days. CONCLUSIONS: This modified version of the Abbott Architect assay is clearly improved compared to the previous one and presents a better agreement with the LC-MS/MS. [less ▲]

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See detailP.Tebt. 526v: A Land Registry from Tebtunis
Nocchi Macedo, Gabriel ULg; Gilbert, Nathan

in Bulletin of the American Society of Papyrologists (in press)

Edition of a Greek land registry from Tebtunis

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See detailMultiple markers of HVC neurogenesis in the canary
Shevchouk, Olesya ULg; Ball, G.F.; Cornil, Charlotte ULg et al

in PLoS ONE (in press)

In songbirds, neurogenesis in the song control nucleus HVC is sensitive to the hormonal and social environment but the dynamics of this process is difficult to assess with a single exogenous marker of new ... [more ▼]

In songbirds, neurogenesis in the song control nucleus HVC is sensitive to the hormonal and social environment but the dynamics of this process is difficult to assess with a single exogenous marker of new neurons. We simultaneously used three independent markers to investigate HVC neurogenesis in male and female canaries. Males were castrated, implanted with testosterone and housed either alone (M), with a female (M-F) or with another male (M-M) while females were implanted with 17β- estradiol and housed with a male (F-M). All subjects received injections of the two thymidine analogues, BrdU and of EdU, respectively 21 and 10 days before brain collection. Cells containing BrdU or EdU or expressing doublecortin (DCX), which labels newborn neurons, were quantified. Social context and sex differentially affected total BrdU+, EdU+, BrdU+EdU- and DCX+ populations. M-M males had a higher density of BrdU+ cells in the ventricular zone adjacent to HVC and of EdU+ in HVC than M-F males. M birds had a higher ratio of BrdU+EdU- to EdU+ cells than M-F subjects suggesting higher survival of newer neurons in the former group. Total number of HVC DCX+ cells was lower in M-F than in M-M males. Sex differences were also dependent of the type of marker used. Several technical limitations associated with the use of these multiple markers were also identified. These results indicate that proliferation, recruitment and survival of new neurons can be independently affected by environmental conditions and effects can only be fully discerned through the use of multiple neurogenesis markers. [less ▲]

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See detailBetween Atlantic and Mediterranean: Changes in technology during the Late Glacial in Western Europe and the climate hypothesis
Naudinot, Nicolas; Tomasso, Antonin ULg; Messager, Erwann et al

in Quaternary International (in press)

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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULg; Simon, Jessica ULg; Bahri, Mohamed Ali ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (in press)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailIncreasing the salience of fluency cues does not reduce the recognition memory impairment in Alzheimer’s disease!
Simon, Jessica ULg; Bastin, Christine ULg; SALMON, Eric ULg et al

in Journal of Neuropsychology (in press)

In Alzheimer’s disease (AD), it is now well established that recollection is impaired from the beginning of the disease, whereas findings are less clear concerning familiarity. One of the most important ... [more ▼]

In Alzheimer’s disease (AD), it is now well established that recollection is impaired from the beginning of the disease, whereas findings are less clear concerning familiarity. One of the most important mechanisms underlying familiarity is the sense of familiarity driven by processing fluency. In this study, we attempted to attenuate recognition memory deficits in AD by maximizing the salience of fluency cues in two conditions of a recognition memory task. In one condition, targets and foils have been created from the same pool of letters (Overlap condition). In a second condition, targets and foils have been derived from two separate pools of letters (No-Overlap condition), promoting the use of letter-driven visual and phonetic fluency. Targets and foils were low-frequency words. The memory tasks were performed by 15 patients with AD and 16 healthy controls. Both groups improved their memory performance in the No-Overlap condition compared to the Overlap condition. Patients with AD were able to use fluency cues during recognition memory as older adults did, but this did not allow to compensate for dysfunction of recognition memory processes. [less ▲]

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See detailTraduction de "Sense and Its Place in Meaning" de W.V.O. Quine
Moreau, Timothée ULg

in Philosophie (in press)

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See detailModeling structures in fire with SAFIR®: Theoretical background and capabilities
Franssen, Jean-Marc ULg; Gernay, Thomas ULg

in Journal of Structural Fire Engineering (in press)

Purpose: This paper describes the theoretical background and main hypotheses at the basis of SAFIR®, a nonlinear finite element software for modeling structures in fire. The paper also explains how to use ... [more ▼]

Purpose: This paper describes the theoretical background and main hypotheses at the basis of SAFIR®, a nonlinear finite element software for modeling structures in fire. The paper also explains how to use the software at its full extent. The discussed numerical modeling principles can be applied with other similar software. Approach: Following a general overview of the organization of the software, the thermal analysis part is explained, with the basic equations and the different possibilities to apply thermal boundary conditions (compartment fire, localized fire, etc.). Next, the mechanical analysis part is detailed, including the time integration procedures and the different types of finite elements: beam, truss, shell, spring and solid. Finally, the material laws are described. The software capabilities and limitations are discussed throughout the paper. Findings: By accommodating multiple types of finite elements and materials, by allowing the user to consider virtually any section type and to input the fire attack in multiple forms, the software SAFIR® is a comprehensive tool for investigating the behavior of structures in the fire situation. Meanwhile, being developed exclusively for its well-defined field of application, it remains relatively easy to use. Value: The paper will improve the knowledge of readers (researchers, designers and authorities) about numerical modeling used in structural fire engineering in general and the capabilities of a particular software largely used in the fire engineering community. [less ▲]

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See detailActivation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment
Dupuis, Nadine ULg; Laschet, Céline ULg; Franssen, Delphine ULg et al

in Molecular Pharmacology (in press)

G protein-coupled receptors are the most important drug targets for human diseases. An important number of them remain devoid of confirmed ligands. GPR27 is one of these orphan receptors, characterized by ... [more ▼]

G protein-coupled receptors are the most important drug targets for human diseases. An important number of them remain devoid of confirmed ligands. GPR27 is one of these orphan receptors, characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. In addition, it has recently been linked to insulin secretion. However, the absence of endogenous or surrogate ligands for GPR27 complicates the examination of its biological function. Our aim was to validate GPR27 signaling pathways and therefore we sought to screen a diversity oriented synthesis library to identify GPR27-specific surrogate agonists. In order to select an optimal screening assay, we investigated GPR27 ligand-independent activity. Both in G protein-mediated pathways and in β-arrestin 2 recruitment, no ligand-independent activity could be measured. However, we observed a recruitment of β-arrestin 2 to a GPR27V2 chimera in the presence of membrane-anchored β-adrenergic receptor kinase 1 (GRK2). Therefore, we optimized a firefly luciferase complementation assay to screen against this chimeric receptor. We identified two compounds (N-[4-(anilinocarbonyl)phenyl]-2,4-dichlorobenzamide (ChemBridge ID5128535) and 2,4-dichloro-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}benzamide (ChemBridge ID5217941)) sharing a N-phenyl-2,4-dichlorobenzamide scaffold, which were selective for GPR27 over its closely related family members GPR85 and GPR173. The specificity of the activity was confirmed with a NanoBiT® β-arrestin 2 assay, imaging of GFP-tagged β-arrestin 2 and PathHunter® β-arrestin 2 Assay. Interestingly, no G protein activation was detected upon activation of GPR27 by these compounds. Our study provides the first selective surrogate agonists for the orphan GPR27. [less ▲]

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See detailVocal change patterns during a teaching day: Inter- and intra-subject variability
Remacle, Angélique ULg; Garnier, Maëva; Gerber, Silvain et al

in Journal of Voice (in press)

Objectives: To describe the mean voice changes of 22 female teachers during a typical workday, examine the inter- and intra-subject variability, and establish a typology of different voice patterns during ... [more ▼]

Objectives: To describe the mean voice changes of 22 female teachers during a typical workday, examine the inter- and intra-subject variability, and establish a typology of different voice patterns during the workday. Methods: For each participant, fundamental frequency (F0), harmonics-to-noise ratio (HNR), jitter, and shimmer were measured on sustained vowels at the beginning and at the end of the workday, at three different times during the school year. Results: The group mean pattern showed significant increases in F0 and HNR during the workday and significant decreases in jitter and shimmer. However, considerable inter- and intra-subject variability was observed. Based on the variation in the acoustic parameters during the workday, three different voice patterns were identified. The first is characterized by a greater F0 increase during the day, interpreted as a common, appropriate adaptation to vocal load. The second is characterized by a greater increase in HNR during the day and greater decreases in jitter and shimmer, interpreted as hyperfunctional voice production. The third is characterized by greater decreases in F0 and HNR and greater increases in jitter and shimmer, suggesting acute inflammation or muscle fatigue following the workday. Conclusions: The observed variety of vocal patterns during the workday emphasizes the need to study this phenomenon individually and target different types of behaviors in order to develop tailored prevention and treatment methods. [less ▲]

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See detailAdvances in diagnosis and management of familial pituitary adenomas
JEDIDI, Haroun ULg; ROSTOMYAN, Lilith; POTORAC, Iulia et al

in International Journal of Endocrine Oncology (in press)

Familial pituitary adenomas accounts for approximately 5-8 % of all pituitary adenomas. Besides the adenomas occurring as part of syndromic entities that bring together several endocrine or other systems ... [more ▼]

Familial pituitary adenomas accounts for approximately 5-8 % of all pituitary adenomas. Besides the adenomas occurring as part of syndromic entities that bring together several endocrine or other systems disorders, 2-3% of the familial pituitary adenomas fit into the familial isolated pituitary adenomas (FIPA) syndrome. 20% of FIPA syndromes have shown mutations in the AIP gene and have distinct clinical characteristics. Recent findings have isolated a new non-AIP FIPA syndrome called X-LAG, resulting from duplication in GPR-101 gene. These new advances in the field of pituitary disease are opening up a new challenging domain to both clinician and researcher. This review will focus on these last findings and their contribution to the diagnosis and the management of familial pituitary adenomas. [less ▲]

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See detailOrganocatalytic coupling of CO2 with a propargylic alcohol: a comprehensive study of the reaction mechanism combining in- situ ATR-IR spectroscopy and DFT calculations
Boyaval, Amélie ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

in ChemSusChem (in press)

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR ... [more ▼]

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR spectroscopy and DFT calculations. Bicyclic guanidines, namely TBD and MTBD, are effective catalysts for the conversion of 2-methyl-3-butyn-2-ol to α-methylene cyclic carbonate and oxoalkyl acyclic carbonate under mild reaction conditions. The lower selectivity of TBD in comparison with MTBD towards the formation of α-methylene cyclic carbonate was elucidated from DFT calculations and is related to the bifunctional activity (base/H-bond donor) of TBD decreasing the Gibbs free energy of the reaction path for the formation of the acyclic carbonate. Introduction [less ▲]

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See detailRobbe-Grillet va plus loin avec l'Express... Le romancier face à l'entretien journalistique
Lorent, Fanny ULg

in Interférences Littéraires = Literaire Interferenties (in press)

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See detailNew insight on Carboniferous (Viséan) brachiopods from eastern Tafilalt (Morocco)
Mottequin, Bernard; Denayer, Julien ULg; Herbig, Hans-Georg et al

in Geological Journal (in press)

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See detailInvestigation on Water Productivity of Winter Wheat Based on MODIS and SEBAL in the Huang-Huai-Hai Plain, China
Yang, Jian-ying; HUO, Zhi-guo; Wu, Ding-rong et al

in Chinese Journal of Agrometeorology (in press)

Understanding how the productivity of water can be increased is widely accepted to be a high priority where water resources are currently scarce and/or over-exploited in China. As the primary data source ... [more ▼]

Understanding how the productivity of water can be increased is widely accepted to be a high priority where water resources are currently scarce and/or over-exploited in China. As the primary data source, MODIS remote sensing, statistics, meteorological data, crop growth period data and ground truth-data from Jan. 2011 to Dec. 2012 were used in actual evapotranspiration estimation, yields rasterizing, and water productivity calculation for winter wheat in the Huang-Huai-Hai Plain (3H Plain). The statistical data were synthesized to calculate district-state-level land productivity, which is then further extrapolated to pixel-level values using a MODIS NDVI image, based on a crop dominance map. Spatial variation of crop water productivity was investigated in order to reveal the key factors of crop water productivity. In addition, the relationship between water productivity and actual evapotranspiration and in subsequence yield for winter wheat was discussed in 3H Plain. The main results indicated that the SEBAL is suitable for estimating evapotranspiration in winter wheat based on the comparation between evapotranspiration measured by Yucheng (in Shandong province). The regional average value of water productivity for winter wheat was detected to be 1.21kg·m-3, with the higher value in Beijing, Tianjin, north part of Shandong province and south part of Hebei province. The pronounced relationship of spatial correlation of the yield and water productivity for winter wheat indicated that the increasing yield governed the increment of water productivity for winter wheat in the coastal land-farming-fishing area (zone1), low plain-hydropenia irrigable land and dry land zone (zone2) and basin- irrigable land and dry land (zone5). The increasing water productivity for winter wheat was recognized to be controlled by rather the increment of yield than the reduction of actual evapotranspiration for winter wheat in the piedmont plain-irrigable land (zone2). Whereas, the pronounced relationship of negative correlation of water productivity and actual evapotranspiration for winter wheat described that only the reduction of actual evapotranspiration was responsible for the increment of water productivity for winter wheat in hill-wet hot paddy-paddy field (zone6). The results is expected to provide a basis information for agricultural water management, improvement of crop water productivity and choice of adaptive mechanism under climate change in Huang-Huai-Hai plain. [less ▲]

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See detailFrom Ontology to Psychoanalysis. Benussi and Musatti on the Concept of Mental Reality
Boccaccini, Federico ULg

in Meinong Studies / Meinong Studien (2018), 9

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See detailScience-fiction et jeu vidéo
Delbouille, Julie ULg; Dozo, Björn-Olav ULg; Jousten, Lison ULg

in ReS Futurae : Revue d'Etudes sur la Science-Fiction (2018), 12

Lorsque Spacewar!, considéré comme un des premiers jeux vidéo, voit le jour en 1962 dans les salles du Massachussets Institute of Technology, il marque le début d’une longue relation entre ce médium et la ... [more ▼]

Lorsque Spacewar!, considéré comme un des premiers jeux vidéo, voit le jour en 1962 dans les salles du Massachussets Institute of Technology, il marque le début d’une longue relation entre ce médium et la science-fiction. À l’heure où l’informatique est encore fort peu micro, la thématique spatiale que ce précurseur exploite présente en effet un avantage certain : celui de déployer à l’écran un « espace dont la principale caractéristique est le vide [...] un lieu qui exige moins de puissance de calcul » (Triclot, 2011). De l’émergence de cette culture hacker dans les années 1960 à la production actuelle, le jeu vidéo a constamment puisé dans les ressorts propres à la science-fiction – que ce soit les accents cyberpunk d’un Deus Ex : Human Revolution (Square Enix, 2011), l’uchronie d’un Wolfenstein : The New Order (Bethesda Softworks, 2014) ou encore la dystopie constitutive d’un Bioshock (2K Games, 2007). Cette richesse spécifique a pourtant été peu interrogée. [less ▲]

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See detailImpact of spatio-temporal shade dynamics on wheat growth and yield, perspectives for temperate agroforestry
Artru, Sidonie ULg; Garré, Sarah ULg; Dupraz, Christian et al

in European Journal of Agronomy (2017)

A stumbling block to the adoption of silvoarable agroforestry systems is the lack of quantitative knowledge on the performance of different crops when competing for resources with trees. In North-Western ... [more ▼]

A stumbling block to the adoption of silvoarable agroforestry systems is the lack of quantitative knowledge on the performance of different crops when competing for resources with trees. In North-Western Europe, light is likely to be the principal limiting resource for understorey crops, and most agronomic studies show a systematic reduction of final yield as shade increases. However the intensity of the crop response depends on both the environmental conditions and the shade characteristics. This study addressed the issue by monitoring winter wheat (Triticum aestivum L.) growth, productivity and quality under artificial shade provided by military camouflage shade-netting, and using the Hi-sAFe model to relate the artificial shade conditions to those applying in agroforestry systems. The field experiment was carried out over two consecutive years (2013–14 and 2014–15) on the experimental farm of Gembloux Agro-Bio Tech, Belgium. The shade structures recreated two shade conditions: periodic shade (PS) and continuous shade (CS), with the former using overlapping military camouflage netting to provide discontinuous light through the day, and the latter using conventional shade cloth. The experiment simulated shading from a canopy of late-flushing hybrid walnut leaves above winter wheat. Shading was imposed 16 (2013–14) and 10 (2014–15) days before flowering and retained until harvest. The crop experienced full light conditions until the maximum leaf area index stage (LAImax) had been reached. In both years, LAI followed the same dynamics between the different treatments, but in 2013–2014 an attack of the take-all disease (Gaeumannomyces graminis var. tritici) reduced yields overall and prevented significant treatment effects. In season 2014–15 the decrease in global radiation reaching the crop during a period of 66 days (CS: – 61% and PS: – 43%) significantly affected final yield (CS: – 45% and PS: – 25%), mainly through a reduction of the average grain weight and the number of grain per m2. Grain protein content increased by up to 45% under the CS treatment in 2015. Nevertheless, at the plot scale, protein yield (t/ha) did not compensate for the final grain yield decrease. The Hi-sAFe model was used to simulate an agroforestry plot with two lines of walnut trees running either north-south or east-west. The levels of artificial shade levels applied in this experiment were compared to those predicted beneath trees growing with similar climatic conditions in Belgium. The levels used in the CS treatment are only likely to occur real agroforestry conditions on 10% of the cropped area until the trees are 30 years old and only with east-west tree row orientation. [less ▲]

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See detailCompte-rendu de l'ouvrage de Gilbert Gagné : The Trade and Culture Debate Evidence from US Trade Agreements
Vlassis, Antonios ULg

in Revue Québecoise de Droit International (2017)

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See detailA computational stochastic multiscale methodology for MEMS structures involving adhesive contact
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Tribology International (2017), 110

This work aims at developing a computational stochastic multiscale methodology to quantify the uncertainties of the adhesive contact problems due to capillary effects and van der Waals forces in MEMS ... [more ▼]

This work aims at developing a computational stochastic multiscale methodology to quantify the uncertainties of the adhesive contact problems due to capillary effects and van der Waals forces in MEMS. Because the magnitudes of the adhesive forces strongly depend on the surface interaction distances, which in turn evolve with the roughness of the contacting surfaces, the involved structural behaviors suffer from a scatter. To numerically predict the probabilistic behaviors of structures involving adhesion, the proposed method introduces stochastic meso-scale random apparent contact forces which can be integrated into a stochastic finite element model. Because the evaluation of their realizations is expensive, a generator for the random apparent contact force using the polynomial chaos expansion is constructed in an efficient way. [less ▲]

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See detailNumerical modelling of micro-plasto-hydrodynamic lubrication in plane strip drawing
Carretta, Yves ULg; Bech, Jakob; Legrand, Nicolas et al

in Tribology International (2017), 110

This paper presents a new finite element model capable of predicting the onset of micro-plasto-hydrodynamic (MPH) lubrication and the amount of lubricant escaping from surface pockets in metal forming ... [more ▼]

This paper presents a new finite element model capable of predicting the onset of micro-plasto-hydrodynamic (MPH) lubrication and the amount of lubricant escaping from surface pockets in metal forming. The present approach is divided in two steps. First, a simulation at the macroscopic level is conducted. Then, a second simulation highlighting microscopic liquid lubrication mechanisms is achieved using boundary conditions provided by the first model. These fluid-structure interaction computations are made possible through the use of the Arbitrary Lagrangian Eulerian (ALE) formalism. The developed methodology is validated by comparison to experimental measurements conducted in plane strip drawing. The effect of physical parameters like the drawing speed, the die angle and the strip thickness reduction is investigated. The numerical results show good agreement with experiments. [less ▲]

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See detailInsect fatty acids: A comparison of lipids from three Orthopterans and Tenebrio molitor L. larvae
Paul, Aman ULg; Frederich, Michel ULg; Caparros Megido, Rudy ULg et al

in Journal of Asia-Pacific Entomology (2017), 20(2), 337-340

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and ... [more ▼]

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and compared with those of Tenebrio molitor larvae. A. domesticus, Co. discolor, Ch. parallelus and T. molitor larvae were found to contain approximately 15%, 13%, 10% and 32% lipids on dry weight, respectively. The lipids from three Orthopterans contain much higher amounts of essential fatty acids than those of T. molitor larvae. The two Orthopterans of the suborder Ensifera i.e., A. domesticus and Co. discolor contain linoleic acid in major quantities, while Ch. parallelus of the suborder Caelifera, contain α-linolenic acid in major quantities. The consumption of linoleic and α-linolenic fatty acid is linked with numerous health promoting effects. The factors that contribute to differences in fatty acid profiles of these insects are being discussed. At last the nutritional parameters including polyunsaturated to saturated and omega 6 to omega 3 fatty acid ratios of these insect lipids are also being discussed to understand the potential role of these lipids in human nutrition. [less ▲]

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See detailA decision support tool for transient stability preventive control
Pertl, Michael; Weckesser, Johannes ULg; Rezkalla, Michel et al

in Electric Power Systems Research (2017), 147

The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the ... [more ▼]

The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the state of the power system in terms of transient stability. A time-domain approach is used to assess the transient stability for potentially critical faults. Potential critical fault locations are identified by a critical bus screening through analysis of pre-disturbance steady-state conditions. The identified buses are subject to a fast critical contingency screening determining the actual critical contingencies/buses. These two screenings aim at reducing the computational burden of the assessment, since only contingencies considered as critical are taken into account. The critical clearing times for the critical contingencies are determined. A preventive re-dispatch of generators to ensure a predefined minimum critical clearing time for faults at all buses is proposed, while costs are minimized. The results of the assessment are presented to the control room operator, who decides to accept the suggested dispatch or to repeat the assessment considering additional user-specific constraints. The effectiveness of the proposed method is demonstrated on a standard nine-bus and the New England test system. [less ▲]

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See detailMagnetic Shielding Above 1 T at 20 K With Bulk, Large Grain YBCO Tubes Made by Buffer-aided Top Seeded Melt Growth
Wera, Laurent ULg; Fagnard, Jean-François ULg; Kumar, Numbury Devendra et al

in IEEE Transactions on Applied Superconductivity (2017), 27(4),

YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and ... [more ▼]

YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and are observed to reduce axial flux densities of 1.5 T by a factor of 100 at 20 K. Such performances are comparable in magnitude to the record threshold inductions reported for bulk MgB2 and Bi-2212 materials at lower temperatures. Magnetic shielding measurements for open and closed tubes at 77 K also show that the presence of the cap improves substantially the shielding performance at the closed extremity since it reduces the penetration through the open end. This fabrication technique is extremely promising for shielding “dc” stray fields generated by HTS magnets operated in a temperature range obtained by cryocoolers, liquid hydrogen (20 K) or liquid neon (27 K). [less ▲]

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See detailSartre, héritier de Heidegger ? Quelques remarques à propos du circuit de l'ipséité dans "L'Être et le Néant".
Recchia, Fabio ULg

in Revista Ética e Filosofia Política (2017), 1

Dans le champ de la philosophie française contemporaine, la filiation philosophique entre Heidegger et Sartre continue de poser question à leurs successeurs. Faut-il concevoir le second comme le simple ... [more ▼]

Dans le champ de la philosophie française contemporaine, la filiation philosophique entre Heidegger et Sartre continue de poser question à leurs successeurs. Faut-il concevoir le second comme le simple promulgateur des doctrines phénoménologiques du premier ? dans quelle mesure, en effet, Sartre est-il l'héritier de la pensée heideggérienne ? Telle est la question que nous réexaminons dans notre texte en mobilisant un développement précis de L'Être et le Néant : la théorie du circuit de l'ipséité. Sur cette base nous mettons en évidence la manière dont l'ontologie phénoménologique nuance la pensée heideggérienne à partir de la philosophie de Bergson et l'anthropologie de Mauss - ouvrant ainsi la voie au projet des psychanalyses existentielles qui articule un dialogue entre la phénoménologie et les sciences sociales françaises autour du problème de la constitution de l'identité personnelle. [less ▲]

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See detailPeriod–luminosity relations of fast-rotating B-type stars in the young open cluster NGC 3766
Saio, H.; Ekström, S.; Mowlavi, N. et al

in Monthly Notices of the Royal Astronomical Society (2017), 467(4), 3864-3873

We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We ... [more ▼]

We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We compare the properties of prograde sectoral g and retrograde r modes excited by the κ mechanism at the Fe opacity peak with the newly discovered period–luminosity relation that is obeyed by a group of fast-rotating B-type stars in the young open cluster NGC 3766. The observed relation consists of two sequences in the period versus magnitude diagram, at periods shorter than 0.5 d. We find that this property is consistent with similar period–luminosity relations predicted for excited sectoral prograde g modes of azimuthal orders m = −1 and −2 in fast-rotating stars along an isochrone. We further show that some of the rapidly rotating stars that have photometric variability with periods longer than a day may be caused by r-mode pulsation predicted to be excited in these stars. One fast-rotating star, in particular, shows both short and long periods that can be explained by the simultaneous excitation of g- and r-mode pulsations in models of fast-rotating stars. [less ▲]

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See detailIdentification of non-stationary dynamical systems using multivariate ARMA models
Bertha, Mathieu ULg; Golinval, Jean-Claude ULg

in Mechanical Systems and Signal Processing (2017), 88

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal ... [more ▼]

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal identification of linear time invariant systems, and time-varying autoregressive moving average models (TV-ARMA) for the identification of nonstationary systems, a time-varying ARMAV (TV-ARMAV) model is presented for the multivariate identification of time-varying systems. It results in the identification of not only the time-varying poles of the system but also of its respective time-varying mode shapes. The method is applied on a time-varying structure composed of a beam on which a mass is moving. [less ▲]

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See detailIn vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review
Pestieau, Aude ULg; Evrard, Brigitte ULg

in European Journal of Pharmaceutical Sciences (2017), 102

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]

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See detailFinite element model reduction for space thermal analysis
Jacques, Lionel ULg; Béchet, Eric ULg; Kerschen, Gaëtan ULg

in Finite Elements in Analysis and Design (2017), 127

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]

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See detailCo-creating service recovery after service failure: The role of brand equity
Hazee, Simon ULg; Van Vaerenbergh, Yves; Armirotto, Vincent

in Journal of Business Research (2017), 74

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See detailDiscovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry
Echterbille, Julien; Gilles, Nicolas; Araoz, Romulo et al

in Toxicon (2017), 130

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]

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See detailDiversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics
Degueldre, Michel; Verdenaud, Marion; Garikoitz, Legarda et al

in Toxicon (2017), 130

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top ... [more ▼]

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from Conus venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species. [less ▲]

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See detailModeling the strain localization around an underground gallery with a hydro-mechanical double scale model; effect of anisotropy
van den Eijnden, AP; Bésuelle, Pierre; Collin, Frédéric ULg et al

in Computers and Geotechnics (2017), 85

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See detailIsotopic half-life and enrichment factor in two species of European freshwater fish larvae: an experimental approach
Latli, Adrien; Sturaro, Nicolas ULg; Dujardin, Nelson et al

in Rapid Communications in Mass Spectrometry (2017), 31(8), 685-692

RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue ... [more ▼]

RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue enrichment factor (TEF) and half-life (HL). We experimentally compared TEF and HL in two freshwater fish larvae. We hypothesised that chub had a better growth/tissue replacement ratio than roach, due to the use of a food closer to their natural diet. METHODS: We determined the isotopic HL, the TEF and the contribution of growth or metabolic tissue replacement to dynamic isotopic incorporation. After yolk sac resorption, larvae were fed for 5 weeks with prey similar to their natural diet (Artemia nauplii) up to the isotopic equilibrium followed by Chironomid larvae. Stable isotope measurements were carried out using a continuous flow isotope ratio mass spectrometer coupled to an elemental analyser. RESULTS: Changes in isotopic composition strongly followed the predictions of exponential growth and time-dependent models. The isotopic HL varied between 8.2 and 12.6 days and the TEF of nitrogen and carbon ranged from 1.7 to 2.1‰ and from –0.9 to 1.2 ‰, respectively. The incorporation of dietary 13C was due more to the production of new tissue (between 56 and 79%) than to the metabolic process. Chub allocated more energy to growth than roach and the Chironomidae diet contributed more to the consumers’ growth than the Artemia diet. CONCLUSIONS: Metabolic rates seemed lower for chub than for roach, especially when they were fed with Chironomidae. A Chironomidae-based diet would be more profitable to chub, and the high associated growth rate could increase the development of the fish larvae. The HL and TEF were in the range of those reported in the literature. These results will be helpful for field-based studies, because they can help to increase the accuracy of models. [less ▲]

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See detailBaelo dans l'Antiquité tardive. L'occupation du secteur sud-est du forum entre les IIIe et VIe s.
Brassous, Laurent; Deru, Xavier ULg; Rodriguez, Oliva et al

in Melanges de la Casa de Velazquez (2017), 47(1),

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon ... [more ▼]

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon et de réoccupation entre les IIIe et VIe s. Les structures découvertes ainsi que le nombreux mobilier qui leur était associé (monnaies, céramique, verre, métal, faune, etc.) fournissent un éclairage nouveau sur l’histoire et la nature de l’agglomération dans l’antiquité tardive, qui entre la fin du IVe s. et son abandon définitif au VIe s. ressemble moins à une ville qu’à un gros village. [less ▲]

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See detailUsefulness of multi-breed models in genetic evaluation of direct and maternal calving ease in Holstein and Belgian Blue Walloon purebreds and crossbreds
Vanderick, Sylvie ULg; Gillon, Alain; Glorieux, Géry et al

in Livestock Science (2017), 198

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and ... [more ▼]

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and crossbred animals. Variance components and derived genetic parameters for purebred BBB and HOL animals were estimated by using single-breed linear animal models. This analysis showed clear genetic differences between breeds. Estimates of direct and maternal heritabilities (± standard error) were 0.34 (±0.02) and 0.09 (±0.01) for BBB, respectively, but only 0.09 (±0.01) and 0.04 (±0.01) for HOL, respectively. Moreover, a significant negative genetic correlation between direct and maternal effects was obtained in both breeds: −0.46 (±0.04) for BBB and −0.29 (±0.11) for HOL. Variance components and derived genetic parameters for purebred BBB and HOL and crossbred BBB ×× HOL cattle were then estimated by using two multi-breed linear animal models: a multi-breed model based on a random regression test-day model (Model MBV), and a multi-breed model based on the random regression multi-breed model (Model MBSM). Both multi-breed models use different functions of breed proportions as random regressions, thereby enabling modelling different additive effects according to animal's breed composition. The main difference between these models is the way in which relationships between breeds are accounted for in the genetic (co)variance structure. Genetic parameters differed between single-breed and multi-breed analysis, but are similar to the literature. For BBB, estimates of direct and maternal heritabilities (±SE) were 0.45 (±0.07) and 0.08 (±0.01) by using Model MBV, and 0.45 (±0.08) and 0.09 (±0.02) for Model MBSM, respectively. For HOL, these estimates were 0.18 (±0.04) and 0.05 (±0.01) using Model MBV, and 0.16 (±0.04) and 0.05 (±0.01) for Model MBSM, respectively. Reliability gains (up to 25%) indicated that the use of crossbred data in the multi-breed models had a positive influence on the estimation of genetic merit of purebred animals. A slight re-ranking of purebred sires and maternal grandsires was observed between single-breed and multi-breed models. Moreover, both multi-breed models can be considered as quasi-equivalent models because they performed almost equally well with respect to MSE and correlations, for purebred and crossbred animals. [less ▲]

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See detailThe Semiotics of Design in Media Visualization: Mereology and Observation Strategies
Dondero, Maria Giulia ULg

in Information Design Journal (2017)

The purpose of this paper is to discern in what ways the semiotic methods of the Post- Greimasian French structuralist and the American Peircian traditions can enrich the study of contemporary methods of ... [more ▼]

The purpose of this paper is to discern in what ways the semiotic methods of the Post- Greimasian French structuralist and the American Peircian traditions can enrich the study of contemporary methods of computational analysis of culture, particularly in the field of Cultural Analytics as implemented by the Russian Art Historian and Computer Scientist Lev Manovich. These semiotic approaches will be helpful in understanding what kinds of visualizations are being generated for use in Cultural Analytics, and what kinds of operations the observer must perform in order to experiment with scientific visualizations of this information. [less ▲]

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See detailImpact of tillage on greenhouse gas emissions by an agricultural crop and dynamics of N2O fluxes: Insights from automated closed chamber measurements
Lognoul, Margaux ULg; Theodorakopoulos, Nicolas ULg; Hiel, Marie-Pierre ULg et al

in Soil & Tillage Research (2017), 167

Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O ... [more ▼]

Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O fluxes. Gas measurements were performed from June to October 2015 in a Belgian maize crop, with homemade automated closed chambers, allowing continuous measurement at a high temporal resolution. After 7 years of treatment, CO2 and N2O average emissions were significantly larger in the RT parcel than in the CT parcel. This observation was attributed to the effect of tillage on the distribution of crop residues within the soil profile, leading to higher soil organic C and total N contents and a greater microbial biomass in the upper layer in RT. A single N2O emission peak triggered by a sudden increase of water- filled pore space (WFPS) was observed in the beginning of the measuring campaign. The absence of large emission afterwards was most likely due to a decreasing availability of N as crop grew. N2O background fluxes showed to be significantly correlated to CO2 fluxes but not to WFPS, while the influence of soil temperature remained unclear. Our results question the suitability of reduced tillage as a “climate-smart” practice and suggest that more experiments be conducted on conservation practices and their potent negative effect on environment. [less ▲]

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See detailMicrofossils from the late Mesoproterozoic – early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern Africa
Beghin, Jérémie ULg; Storme, Jean-Yves; Blanpied, Christian et al

in Precambrian Research (2017), 291

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

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See detailTranscriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.
tarifeno-Saldiva, estefania; Lavergne, Arnaud ULg; Bernard, Alice et al

in BMC Biology (2017), 15

Background Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the ... [more ▼]

Background Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the function of the different pancreatic cell types has been maintained during vertebrate evolution, the comparison of their transcriptomes across distant vertebrate species is a mean to pinpoint genes under strong evolutionary constrains due to their crucial function and which have preserved their selective expression in these pancreatic cell types. Results In this study, RNA-sequencing was performed on pancreatic alpha-, beta- and delta endocrine cells as well as the acinar and ductal exocrine cells isolated from adult zebrafish transgenic lines. Comparison of these transcriptomes identified many novel markers including transcription factors and signaling pathways components specific for each cell type. By performing interspecies comparisons, we identified hundreds of genes with conserved enriched expression in endocrine and exocrine cells among human, mouse and zebrafish. This list includes many genes known as crucial for pancreatic cell formation or function, but also pinpoints many factors whose pancreatic function is still unknown. A large set of endocrine-enriched genes can already be detected at early developmental stages as revealed by the transcriptomic profiling of embryonic endocrine cells, indicating a potential role in cell differentiation. The actual involvement of conserved endocrine genes in pancreatic cell differentiation was demonstrated in zebrafish for myt1b, whose invalidation leads to a reduction of alpha-cells, and for cdx4, selectively expressed in endocrine delta-cells and crucial for their specification. Intriguingly, comparison of the endocrine alpha- and beta-cell subtypes from human, mouse and zebrafish reveals a much lower conservation of the transcriptomic signatures for these two endocrine cell subtypes compared to the signatures of pan-endocrine and exocrine cells. These data suggest that the identity of the alpha- and beta-cells relies on a few key factors, corroborating numerous examples of inter-conversion between these two endocrine cell subtypes. Conclusion. This study highlights both evolutionary conserved and species-specific features that will help to unveil universal and fundamental regulatory pathways as well as pathways specific to human and laboratory animal models such as mouse and zebrafish. [less ▲]

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See detailSimultaneous synthesis and chemical functionalization of emulsion-templated porous polymers using nitroxide-terminated macromolecular surfactants
Mathieu, Kevin ULg; De Winter, Julien; Jérôme, Christine ULg et al

in Polymer Chemistry (2017), 8(11), 1850-1861

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in ... [more ▼]

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in tedious multi-steps processes. This work describes a straightforward macromolecular surfactant-assisted method for producing chemically functionalized macroporous polyHIPEs with interconnected structures. Accordingly, high internal phase emulsion-templated polymerizations were implemented in the presence of SG1-terminated amphiphilic copolymers prepared by nitroxide- mediated radical polymerization (NMP). The latter served as both stabilizers and functionalizing agents upon thermal activation of its terminal alkoxyamine and covalent anchoring of the released radical copolymer onto the walls of the scaffold. The effect of the polymerization temperature on the functionalization and openness of the final porous materials was explored. As a result, a range of open-cell styrene and acrylate-based polyHIPEs chemically grafted with PEO were obtained. Moreover, polyHIPEs were also decorated with alkyne-bearing PEO and subsequently modified via CuAAc click chemistry in order to demonstrate the potential of this macromolecular surfactants-assisted functionalization method. [less ▲]

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See detailInfluence of granular fraction and origin of recycled concrete aggregates on their properties
Zhao, Zengfeng ULg; Courard, Luc ULg; Michel, Frédéric ULg et al

in European Journal of Environmental and Civil Engineering (2017)

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of ... [more ▼]

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of the granular fraction and the origin of RCA on their properties. In this study, RCA from industrial produced blocks (RCA_Blocks) and slabs (RCA_Slabs) were crushed and then separated into four granular fractions (0/2, 2/6.3, 6.3/14, 14/20 mm). Each granular fraction of RCA was physically characterised. Real RCA from recycling plant were also used for comparison. The results showed that recycled sands offered significantly higher cement paste content (higher bound water content) than coarse recycled aggregates. The fine RCA had therefore a higher water absorption coefficient compared to coarser fractions of RCA. The water absorption of finer fraction of RCA could be extrapolated precisely from the relationship between water absorption and cement paste content (or bound water content) of three coarse fractions of RCA. The values of hardened cement paste content obtained for the RCA_Blocks were lower than those measured on the RCA_Slabs, which was due to a smaller amount of initial cement paste content in blocks. The results showed that RCA_Slabs were more angular than RCA_Blocks. [less ▲]

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See detailStatistics of localized phase slips in tunable width planar point contacts
Baumans, Xavier ULg

in Scientific Reports (2017), 7

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In ... [more ▼]

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In the present work we investigate highly confined phase slips at the contact point of two superconducting leads. Profiting from the high current crowding at this spot, we are able to shrink in-situ the nanoconstriction. This procedure allows us to investigate, in the very same sample, thermally activated phase slips and the probability density function of the switching current I sw needed to trigger an avalanche of events. Furthermore, for an applied current larger than I sw , we unveil the existence of two distinct thermal regimes. One corresponding to efficient heat removal where the constriction and bath temperatures remain close to each other, and another one in which the constriction temperature can be substantially larger than the bath temperature leading to the formation of a hot spot. Considering that the switching current distribution depends on the exact thermal properties of the sample, the identification of different thermal regimes is of utmost importance for properly interpreting the dissipation mechanisms in narrow point contacts. [less ▲]

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See detailModelling of organic Rankine cycle power systems in off-design conditions: an experimentally-validated comparative study
Dickes, Rémi ULg; Dumont, Olivier ULg; Daccord, Rémi et al

in Energy (2017), 123

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development ... [more ▼]

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development, power generation from low-grade heat sources is gaining interest and the organic Rankine cycle (ORC) is seen as one of the most promising technologies for such applications. In this paper, it is proposed to perform an experimentally-validated comparison of different modelling methods for the off-design simulation of ORC-based power systems. To this end, three types of modelling paradigms (namely a constant-efficiency method, a polynomial-based method and a semi-empirical method) are compared both in terms of their fitting and extrapolation capabilities. Post-processed measurements gathered on two experimental ORC facilities are used as reference for the models calibration and evaluation. The study is first applied at a component level (i.e. each component is analysed individually) and then extended to the characterization of the entire organic Rankine cycle power systems. Benefits and limi- tations of each modelling method are discussed. The results show that semi-empirical models are the most reliable for simulating the off-design working conditions of ORC systems, while constant-efficiency and polynomial-based models are both demonstrating lack of accuracy and/or robustness. [less ▲]

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See detailMacroH2A histone variants maintain nuclear organization and heterochromatin architecture.
Douet, Julien; Corujo, David; Malinverni, Roberto et al

in Journal of Cell Science (2017)

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated ... [more ▼]

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated state by a yet unknown mechanism. Here, we present results demonstrating that macroH2A variants have a major function in maintaining nuclear organization and heterochromatin architecture. Specifically, we find that a substantial amount of macroH2A is associated with heterochromatic repeat sequences. We further identify macroH2A on sites of interstitial heterochromatin decorated by H3K9me3. Loss of macroH2A leads to major defects in nuclear organization including reduced nuclear circularity, disruption of nucleoli and a global loss of dense heterochromatin. Domains formed by repeat sequences when depleted of macroH2A are disorganized, expanded and fragmented and mildly re-expressed. On the molecular level we find that macroH2A is required for the interaction of repeat sequences with the nucleostructural protein Lamin B1. Taken together our results argue that a major function of macroH2A histone variants is to link nucleosome composition to higher order chromatin architecture. [less ▲]

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See detailBehavior of digital sequences through exotic numeration systems
Leroy, Julien ULg; Rigo, Michel ULg; Stipulanti, Manon ULg

in Electronic Journal of Combinatorics (2017), 24(1), 14436

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied ... [more ▼]

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied using techniques from analytic number theory or linear algebra. In this paper we develop a method based on exotic numeration systems and we apply it on two examples motivated by the study of generalized Pascal triangles and binomial coefficients of words. [less ▲]

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See detailPhotosynthetic trichomes contain a specific Rubisco with a modified pH9 dependent activity
Laterre, Raphaëlle; Pottier, Mathieu; Remacle, Claire ULg et al

in Plant Physiology (2017)

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See detailBioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule
Thiry, Justine ULg; Kok, Miranda ULg; Collard, Laurence ULg et al

in European Journal of Pharmaceutical Sciences (2017), 99

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt ... [more ▼]

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1 ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three formulations consisted of a simple SOL/ITZ amorphous solid dispersion (ASD), an optimized SOL/ITZ/AcDiSol® (super-disintegrant) ASD and an equimolar inclusion complex of ITZ in hydroxypropyl-β-cyclodextrin (substitution degree = 0.63, CD) with SOL. The three formulations were compared in vitro and in vivo to the marketed product Sporanox®. The in vitro enhancement of dissolution rate was evaluated using a biphasic dissolution test. In vitro dissolution results showed that all three formulations had a higher percentage of ITZ released than Sporanox® with the following ranking: SOL/ITZ/CD > SOL/ITZ/AcDiSol® > SOL/ITZ > Sporanox®. The bioavailability of these four formulations was evaluated in rats. The bioanalytical method was optimized so that only 10 μL of blood was withdrawn from the rats using specific volumetric absorptive microsampling devices. This enabled to keep the same rats during the whole study, which was in accordance with the Three Rs rules (reduction, refinement and replacement). Furthermore, this technique allowed the suppression of inter-individual variability. Higher Cmax and AUC were obtained after the administration of all three formulations compared to the levels after the use of Sporanox® as follows: SOL/ITZ/AcDiSol® > SOL/ITZ/CD > SOL/ITZ > Sporanox®. The inversion in the ranking between SOL/ITZ/CD and SOL/ITZ/AcDiSol® made impossible the establishment of an in vitro–vivo correlation. Indeed, very different release rates were obtained in vitro and in vivo for the two optimized formulations. These results suggest that ITZ would be protected inside the core of the SOL micelles even during the absorption step at the intestine, while some agents present in the intestinal fluids could displace ITZ from the hydrophobic cavity of CD by competition. [less ▲]

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See detailLacustrine clay mineral assemblages as a proxy for land-use and climate changes over the last 4 kyr: The Amik Lake case study, Southern Turkey
El Ouahabi, Meriam ULg; Hubert, Aurelia ULg; Fagel, Nathalie ULg

in Quaternary International (2017), 1/15

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital ... [more ▼]

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital fraction, the lacustrine sediments record the history of soil erosion within its catchment via the inputs of clays and others detrital products. Within a Mediterranean context, the study investigates the upper sediments infilling the central part of the Amik basin in southern Turkey. This tectonic basin was occupied and exploited by modern human at least since 6000-7000 BC. We focus on the clay mineralogy (x-ray diffraction on oriented aggregates) and magnetic susceptibility measurements (Bartington) of the sedimentary record in the area over the last 4000 years, to assess environmental changes in relation with the different land uses and/or weathering during the successive Bronze, Iron, Roman, Islamic/Ottoman and Modern civilizations. The clay fraction of Amik Lake sediments comprises smectite, kaolinite, illite, chlorite and chlorite/smectite mixed layers that are the inherited clay phases. A relative change in abundance and crystallinity and chemistry of illite attests that environmental conditions evolved in the Amik Plain from the Bronze to Modern Age in relation with climates and/or land-use changes. The history of the Amik Lake reveals different soil erosion episode. The most intense erosion phase occurred during the Bronze/Iron Ages as indicated by the clay and magnetic susceptibility proxies. The Roman period was an exceptional period with soil erosion products arriving from the watershed, probably due the water channelization. A reduction of soil erosion occurred during the post Roman period until nowadays. Significant pedogenesis transformations are evidenced, especially during the Islamic/Ottoman periods suggesting intense chemical weathering conditions related to climate change. [less ▲]

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See detailTwo massive rocky planets transiting a K-dwarf 6.5 parsecs away
Gillon, Michaël ULg; Demory, Brice-Olivier; Van Grootel, Valérie ULg et al

in Nature Astronomy (2017), 1

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of ... [more ▼]

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of these planets, HD 219134 b, whose mass and radius (4.5 M[SUB]⊕[/SUB] and 1.6 R[SUB]⊕[/SUB] respectively) are consistent with a rocky composition[SUP]1[/SUP]. Here, we report new high-precision time-series photometry of the star acquired with Spitzer revealing that the second innermost planet of the system, HD 219134c, is also transiting. A global analysis of the Spitzer transit light curves and the most up-to-date HARPS-N velocity data set yields mass and radius estimations of 4.74 ± 0.19 M[SUB]⊕[/SUB] and 1.602 ± 0.055 R[SUB]⊕[/SUB] for HD 219134 b, and of 4.36 ± 0.22 M[SUB]⊕[/SUB] and 1.511 ± 0.047 R[SUB]⊕[/SUB] for HD 219134 c. These values suggest rocky compositions for both planets. Thanks to the proximity and the small size of their host star (0.778 ± 0.005 R[SUB]⊙[/SUB])[SUP]3[/SUP], these two transiting exoplanets — the nearest to the Earth yet found — are well suited for a detailed characterization (for example, precision of a few per cent on mass and radius, and constraints on the atmospheric properties) that could give important constraints on the nature and formation mechanism of the ubiquitous short-period planets of a few Earth masses. [less ▲]

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See detailH0LiCOW - V. New COSMOGRAIL time delays of HE 0435-1223: H0 to 3.8 per cent precision from strong lensing in a flat ΛCDM model
Bonvin, V.; Courbin, F.; Suyu, S. H. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We present a new measurement of the Hubble Constant H[SUB]0[/SUB] and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time ... [more ▼]

We present a new measurement of the Hubble Constant H[SUB]0[/SUB] and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time delays. First, we measure the time delay of HE 0435-1223 from 13-yr light curves obtained as part of the COSMOGRAIL project. Companion papers detail the modelling of the main deflectors and line-of-sight effects, and how these data are combined to determine the time-delay distance of HE 0435-1223. Crucially, the measurements are carried out blindly with respect to cosmological parameters in order to avoid confirmation bias. We then combine the time-delay distance of HE 0435-1223 with previous measurements from systems B1608+656 and RXJ1131-1231 to create a Time Delay Strong Lensing probe (TDSL). In flat Λ cold dark matter (ΛCDM) with free matter and energy density, we find H[SUB]0[/SUB] =71.9^{+2.4}_{-3.0} {km s^{-1} Mpc^{-1}} and Ω _{Λ }=0.62^{+0.24}_{-0.35}. This measurement is completely independent of, and in agreement with, the local distance ladder measurements of H[SUB]0[/SUB]. We explore more general cosmological models combining TDSL with other probes, illustrating its power to break degeneracies inherent to other methods. The joint constraints from TDSL and Planck are H[SUB]0[/SUB] = 69.2_{-2.2}^{+1.4} {km s^{-1} Mpc^{-1}}, Ω _{Λ }=0.70_{-0.01}^{+0.01} and Ω _k=0.003_{-0.006}^{+0.004} in open ΛCDM and H[SUB]0[/SUB] =79.0_{-4.2}^{+4.4} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.02} and w=-1.38_{-0.16}^{+0.14} in flat wCDM. In combination with Planck and baryon acoustic oscillation data, when relaxing the constraints on the numbers of relativistic species we find N[SUB]eff[/SUB] = 3.34_{-0.21}^{+0.21} in N[SUB]eff[/SUB]ΛCDM and when relaxing the total mass of neutrinos we find Σm[SUB]ν[/SUB] ≤ 0.182 eV in m[SUB]ν[/SUB]ΛCDM. Finally, in an open wCDM in combination with Planck and cosmic microwave background lensing, we find H[SUB]0[/SUB] =77.9_{-4.2}^{+5.0} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.03}, Ω _k=-0.003_{-0.004}^{+0.004} and w=-1.37_{-0.23}^{+0.18}. [less ▲]

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See detailH0LiCOW. VI. Testing the fidelity of lensed quasar host galaxy reconstruction
Ding, Xuheng; Liao, Kai; Treu, Tommaso et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

The empirical correlation between the mass of a supermassive black hole (M_BH) and its host galaxy properties is widely considered to be an evidence of their co-evolution. A powerful way to test the co ... [more ▼]

The empirical correlation between the mass of a supermassive black hole (M_BH) and its host galaxy properties is widely considered to be an evidence of their co-evolution. A powerful way to test the co-evolution scenario and learn about the feedback processes linking galaxies and nuclear activity is to measure these correlations as a function of redshift. Unfortunately, currently M_BH can only be estimated in active galaxies at cosmological distances. At these distances, bright active galactic nuclei (AGNs) can outshine the host galaxy, making it extremely difficult to measure the host's luminosity. Strongly lensed AGNs provide in principle a great opportunity to improve the sensitivity and accuracy of the host galaxy luminosity measurements as the host galaxy is magnified and more easily separated from the point source, provided the lens model is sufficiently accurate. In order to measure the M_BH-L correlation with strong lensing, it is necessary to ensure that the lens modelling is accurate, and that the host galaxy luminosity can be recovered to at least a precision and accuracy better than that of the typical M_BH measurement. We carry out extensive and realistic simulations of deep Hubble Space Telescope observations of lensed AGNs obtained by our collaboration. We show that the host galaxy luminosity can be recovered with better accuracy and precision than the typical uncertainty in M_BH(˜0.5 dex) for hosts as faint as 2-4 mag dimmer than the AGN itself. Our simulations will be used to estimate bias and uncertainties in the actual measurements to be presented in a future paper. [less ▲]

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See detailLinking Forest Cover to Water Quality: A Multivariate Analysis of Large Monitoring Datasets
Brogna, Delphine; Michez, Adrien ULg; Jacobs, Sander et al

in Water (2017), 9(3), 176

Forested catchments are generally assumed to provide higher quality water. However, this hypothesis must be validated in various contexts as interactions between multiple land use and land cover (LULC ... [more ▼]

Forested catchments are generally assumed to provide higher quality water. However, this hypothesis must be validated in various contexts as interactions between multiple land use and land cover (LULC) types, ecological variables and water quality variables render this relationship highly complex. This paper applies a straightforward multivariate approach on a typical large monitoring dataset of a highly managed and densely populated area (Wallonia, Belgium; 10-year dataset), quantifying forest cover effects on nine physico-chemical water quality variables. Results show that forest cover explains about one third of the variability of water quality and is positively correlated with higher quality water. When controlling for spatial autocorrelation, forest cover still explains 9% of water quality. Unlike needle-leaved forest cover, broad-leaved forest cover presents an independent effect from ecological variables and explains independently 4.8% of water quality variability while it shares 5.8% with cropland cover. This study demonstrates clear independent effects of forest cover on water quality, and presents a method to tease out independent LULC effects from typical large multivariate monitoring datasets. Further research on explanatory variables, spatial distribution effects and water quality datasets could lead to effective strategies to mitigate pollution and reach legal targets. [less ▲]

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See detailBioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells
Gulfam, Muhammad ULg; Matini, Teresa; Monteiro, Patrícia F et al

in Biomaterials Science (2017), 5(3), 532-550

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we ... [more ▼]

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and cytocompatible block copolymer based on methoxypoly (ethyleneglycol)-b-poly(ε-caprolactone-co-α-azido-ε-caprolactone) (mPEG-b-poly(εCL-co-αN3εCL)) as a precursor of reduction sensitive core-crosslinked micelles. The synthesized polymer was formulated as micelles using a dialysis method and loaded with the anti-inflammatory and anti-cancer drug metho- trexate (MTX). The micellar cores were subsequently crosslinked at their pendent azides by a redox- responsive bis(alkyne). The size distributions and morphology of the polymer micelles were assessed using dynamic light scattering (DLS) and transmission electron microscopy, and drug release assays were performed under simplified (serum free) physiological and reductive conditions. Cellular uptake studies in human breast cancer cells were performed using Oregon-green loaded core-crosslinked micelles. The MTX-loaded core-crosslinked micelles were assessed for their effects on metabolic activity in human breast cancer (MCF-7) cells by evaluating the reduction of the dye MTT 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide. The apoptosis inducing potential of MTX-loaded core-crosslinked micelles was analysed using Hoechst/propidium iodide (PI) and annexin-V/PI assays. The data from these experi- ments indicated that drug release from these cross-linked micelles can be controlled and that the redox- responsive micelles are more effective carriers for MTX than non-crosslinked analogues and the free drug in the cell-lines tested. [less ▲]

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See detailWASP-South transiting exoplanets: WASP-130b, WASP-131b, WASP-132b, WASP-139b, WASP-140b, WASP-141b & WASP-142b
Hellier, Coel; Anderson, D. R.; Collier Cameron, A. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with ... [more ▼]

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with [Fe/H] = +0.26. Warm Jupiters tend to have smaller radii than hot Jupiters, and WASP-130b is in line with this trend (1.23 Mjup; 0.89 Rjup). WASP-131b is a bloated Saturn-mass planet (0.27 Mjup; 1.22 Rjup). Its large scale height coupled with the V = 10.1 brightness of its host star make the planet a good target for atmospheric characterisation. WASP-132b is among the least irradiated and coolest of WASP planets, being in a 7.1-d orbit around a K4 star. It has a low mass and a modest radius (0.41 Mjup; 0.87 Rjup). The V = 12.4, [Fe/H] = +0.22 star shows a possible rotational modulation at 33 d. WASP-139b is the lowest-mass planet yet found by WASP, at 0.12 Mjup and 0.80 Rjup. It is a "super-Neptune" akin to HATS-7b and HATS-8b. It orbits a V = 12.4, [Fe/H] = +0.20, K0 star. The star appears to be anomalously dense, akin to HAT-P-11. WASP-140b is a 2.4-Mjup planet in a 2.2-d orbit that is both eccentric (e = 0.047) and with a grazing transit (b = 0.93) The timescale for tidal circularisation is likely to be the lowest of all known eccentric hot Jupiters. The planet's radius is large (1.4 Rjup), but uncertain owing to the grazing transit. The host star is a V = 11.1, [Fe/H] = +0.12, K0 dwarf showing a prominent 10.4-d rotational modulation. The dynamics of this system are worthy of further investigation. WASP-141b is a typical hot Jupiter, being a 2.7 Mjup, 1.2 Rjup planet in a 3.3-d orbit around a V = 12.4, [Fe/H] = +0.29, F9 star. WASP-142b is a typical bloated hot Jupiter (0.84 Mjup, 1.53 Rjup) in a 2.1-d orbit around a V = 12.3, [Fe/H] = +0.26, F8 star. [less ▲]

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