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See detailMontage et résistance du réel chez S. Kracauer: Photographie, cinéma, texte.
Hagelstein, Maud ULg; Hamers, Jérémy ULg

in Bulletin d'Analyse Phénoménologique (in press)

Partant de quelques textes dans lesquels S. Kracauer traite du rapport entre montage et réel, cet article tente de préciser et de problématiser l’ambivalence de Kracauer à l’égard de l’outil « montage » ... [more ▼]

Partant de quelques textes dans lesquels S. Kracauer traite du rapport entre montage et réel, cet article tente de préciser et de problématiser l’ambivalence de Kracauer à l’égard de l’outil « montage », notamment dans le champ cinématographique, en ouvrant la réflexion par cette double question : comment définir un « mauvais usage » du montage et, à l’opposé, comment peuvent se mettre en place les conditions d’un « bon usage » du montage selon Kracauer ? Pour y répondre, les auteurs identifient d'abord, dans l’œuvre de Kracauer, les éléments explicites et implicites (montage textuel) qui permettent de saisir au plus près ce que serait, selon le philosophe et sociologue, le principe de réalité. Ensuite, une œuvre photographique, contemporaine des quelques textes évoqués, Menschen des 20. Jahrhunderts d’August Sander, permet de mieux circonscrire les possibles concrétisations de cette pensée en la mettant à l’épreuve d’une réalisation en images et en montage. [less ▲]

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See detailLes tensions entre langue et politique en Belgique: linguistiques ou communautaires?
Dassargues, Alix ULg; Perrez, Julien ULg; Reuchamps, Min ULg

in Revue Internationale de Politique Comparée (in press)

Since its creation in 1830, Belgium has experienced tensions between language and politics. The question of the linguistic or community-related nature of these tensions should be raised since they have ... [more ▼]

Since its creation in 1830, Belgium has experienced tensions between language and politics. The question of the linguistic or community-related nature of these tensions should be raised since they have regularly been referred to as linguistic by some researchers and as community-related by others. But the choice of these adjectives is not unimportant considering they frame the representations of the political issues at hand. The aim of this article is to tackle this question from the combined perspective of linguistics and political science. In the first, the article explores the genealogy of the adjectives ‘linguistic’ and ‘community-related’ as well as the multiplicity of their uses in the scientific literature. In the second part, it focuses on the ways citizens see and talk about Belgian federalism through the respective analyses of their mental representations and their conceptual metaphors. Such interdisciplinary endeavour, bringing together theoretical and empirical insights, seeks to yield a renewed understanding of the political relations in Belgium and to contribute to the debate about plurilingual societies. [less ▲]

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See detailL'atlas à l'épreuve de l'image en mouvement (Warburg, Farocki, Didi-Huberman)
Hagelstein, Maud ULg; Hamers, Jérémy ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes ... [more ▼]

Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes pour grandes personnes (G. Didi-Huberman, A. Gisinger, 2012), composée pour partie d’images en mouvement, à la pensée de la table warburgienne comme lieu d’une perpétuelle reconfiguration et d’une nouvelle lisibilité du monde. Se pourrait-il en effet qu’une image en mouvement, prise d’ordinaire dans un continuum clos, se dote, à travers le montage, des mêmes potentialités critiques – c’est-à-dire d’un même pouvoir inquiétant – que l’image fixe offerte au déambulateur de l’atlas ? [less ▲]

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See detailCritique du capitalisme néolibéral et travail rhétorique chez Frédéric Lordon : un discours d’affectation.
Provenzano, François ULg; Janvier, Antoine ULg

in Dissensus (in press)

Les ouvrages de Frédéric Lordon ont offert ces dernières années un éclairage nouveau des mécanismes de la finance et du capitalisme en régime néolibéral, en vertu de la place centrale qu’ils accordent aux ... [more ▼]

Les ouvrages de Frédéric Lordon ont offert ces dernières années un éclairage nouveau des mécanismes de la finance et du capitalisme en régime néolibéral, en vertu de la place centrale qu’ils accordent aux affects. Il est frappant que cette entreprise – qui est triple: analyse de la finance, analyse du capitalisme, analyse de la domination – soit doublée d’une attention portée au discours même qui la développe. On peut repérer une telle attention dans la pluralité des genres de discours qu’investit Frédéric Lordon : ouvrages « savants » ou « universitaires », mais aussi courts essais engagés aux éditions Raisons d’agir, articles de presse dans Le Monde Diplomatique notamment, tenue du blog « La pompe à phynance » sur le site du même journal, et même pièce de théâtre récemment adaptée au cinéma, D’un retournement l’autre. Comédie sérieuse sur la crise financière. En quatre actes, et en alexandrins . Diversité de genre entre les différents types de textes, donc. Diversité interne à chacun de ces textes, aussi : le lecteur de Frédéric Lordon se trouve toujours à cheval sur plusieurs codes rhétoriques dont joue l’auteur dans un même ouvrage. On pourrait bien sûr tenir cette double diversité pour la simple conséquence du talent d’écriture de Lordon, ou d’un plaisir pris par l’auteur à jouer du langage et des ethos qu’il construit. Le présent article propose au contraire de considérer cette diversité comme le résultat d’un véritable travail sur les modalités rhétoriques du discours critique sur le capitalisme financiarisé, qu’il faut articuler aux principaux postulats de sa théorie sociale. L’hypothèse défendue sera, précisément, de considérer qu’il y a une construction rhétorique qui participe de l’entreprise critique et, du même coup, qui s’inscrit comme un geste politique dans une « société des affects ». [less ▲]

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See detailOut of Himalaya: the impact of past Asian environmental changes on the evolutionary and biogeographical history of Dipodoidea (Rodentia)
Pisano, Julie ULg; Condamine, Fabien L.; Lebedev, Vladimir et al

in Journal of Biogeography (in press)

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See detailCompte rendu de D. van Mal-Maeder, A. Burnier, L. Núñez (éds.): Jeux de voix. Énonciation, intertextualité et intentionnalité dans la littérature antique
Macedo, Gabriel ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (in press)

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See detailCompte-rendu de l'ouvrage de Boyd Taylor COOLMAN et Dale M. COULTER : Trinity and creation
Close, Florence ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailDefining multiplication in some additive expansions of polynomial rings
Point, Françoise; Rigo, Michel ULg; Waxweiler, Laurent

in Communications in Algebra (in press)

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this ... [more ▼]

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this applies to polynomial rings over a finite field. [less ▲]

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See detailL'espace transitionnel winnicotien et l'_Urraum_ kantien
Seba, Jean-Renaud ULg

in Revista Natureza Humana (in press)

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See detailNegentiende-eeuwse anglofilie in Nederland
Steyaert, Kris ULg

in Spiegel der Letteren (in press), 57(3),

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See detailMolecular patterns of rhizobacteria involved in plant immunity elicitation.
Mariutto, Martin ULg; Ongena, Marc ULg

in Advances in Botanical Research (in press)

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See detailA European survey on attitudes towards pain and end-of-life issues in locked-in syndrome
Demertzi, Athina ULg; Jox, Ralf J; Racine, Eric et al

in Brain Injury (in press)

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in ... [more ▼]

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in syndrome. Methods: Close-ended survey among conference attendees from 33 European countries. Analysis included chi-square tests and logistic regressions. Results: From the 3332 respondents (33% physicians, 18% other clinicians, 49% other professions; 47% religious), 90% agreed that patients with locked-in syndrome can feel pain. The majority (75%) disagreed with treatment withdrawal, but 56% did not wish to be kept alive if they imagined themselves in this condition (p50.001). Religious and southern Europeans opposed to treatment withdrawal more often than non-religious (p50.001) and participants from the North (p¼0.001). When the locked-in syndrome was compared to disorders of consciousness, more respondents endorsed that being in a chronic locked-in syndrome was worse than being in a vegetative state or minimally conscious state for patients (59%) than they thought for families (40%, p50.001). Conclusions: Personal characteristics mediate opinions about locked-in syndrome. The dissociation between personal preferences and general opinions underlie the difference in perspective in disability. Ethical responses to dilemmas involving patients with locked-in syndrome should consider the diverging ethical attitudes of stakeholders. [less ▲]

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See detailKDIGO Guidelines and Kidney Transplantation: Is the cystatin-C Based Recommendation relevant?
Masson, I; Maillard, N; CAVALIER, Etienne ULg et al

in American Journal of Transplantation (in press)

The KDIGO guidelines propose a new approach to diagnose chronic kidney disease (CKD) based on estimated glomerular ®ltration rate (GFR). In patients with a GFR value comprised between 45 and 59 mL/ min/1 ... [more ▼]

The KDIGO guidelines propose a new approach to diagnose chronic kidney disease (CKD) based on estimated glomerular ®ltration rate (GFR). In patients with a GFR value comprised between 45 and 59 mL/ min/1.73m2 as estimated by the CKD-EPI creatinine equation (eGFRcreat), it is suggested to con®rm the diagnosis with a second estimation using the CKD-EPI cystatin C-based equations (eGFRcys/eGFRcreat-cys). We sought to determine whether this new diagnostic strategy might extend to kidney transplant recipients (KTR) and help to identify those with decreased GFR. In 670 KTR for whom a measured GFR was available, we simulated the detection of CKD using the two-steps approach recommended by the guidelines in comparison to the conventional approach relying on creatinine equation. One hundred forty-®ve patients with no albuminuria had eGFRcreat between 45 and 59 mL/ min/1.73m2. Among them, 23% had inulin clearance over 60 mL/min/1.73m2 and were thus incorrectly classi®ed as CKD patients. When applying the Kidney Disease: Improving Global Outcomes (KDIGO) strategy, 138 patients were con®rmed as having a GFR below 60 mL/min with eGFRcreat-cys. However, 21% of them were misclassi®ed in reference to measured GFR. Our data do no not support the use of cystatin C as a con®rmatory test of stage 3A CKD in KTR. [less ▲]

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See detailNewt life after fish introduction: extirpation of paedomorphosis in a mountain fish lake and newt use of satellite pools
Denoël, Mathieu ULg; Scime, Patrick; Zambelli, Nicola

in Current Zoology (in press), 62

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context ... [more ▼]

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context, we determined whether small wetlands, such as pools surrounding fished and fishless lakes, could sustain paedomorphic and metamorphic newts. To this end, we surveyed lakes known historically to sustain Alpine newts (Ichthyosaura alpestris) as well as 35 nearby pools. On the basis of the published records, the only known population exhibiting paedomorphosis in the Swiss Alps was found to be extirpated by salmonid introductions. However, the metamorphs persisted in peripheral pools, paedomorphosis was discovered at a new locality, and overwintering larvae were still present in one of the lakes. These results show the importance of conserving varied aquatic habitats such as pools in mountainous environments where the main resources can become unsuitable for amphibians because of fish introductions. Pools may also function as reservoirs in maintaining newt populations until programs to remove fish from lakes can be carried out. It is not known if paedomorphs could reappear after fish removal. However, the combined resilience of amphibians after fish removal and the genetic basis for paedomorphosis highlighted in other taxa by previous studies suggest that there is the potential to maintain this intraspecific case of diversity even after its disappearance. [less ▲]

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See detailEfficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Fafin, Coraline et al

in Journal of Nephrology (in press)

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies ... [more ▼]

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. Methods In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Results Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m2 and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14–36), 23 (17–31), 31 (22–38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28–44), 35 (29–41), 39 (32–47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/ mL. Conclusions In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D. [less ▲]

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See detailCharacterization of Cichopeptins, New Phytotoxic Cyclic Lipodepsipeptides Produced by Pseudomonas cichorii SF1-54, and Their Role in Bacterial Midrib Rot Disease of Lettuce
Huang, CJ; Pauwelyn, E.; Ongena, Marc ULg et al

in Molecular Plant-Microbe Interactions [=MPMI] (in press)

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See detailCompte-rendu de l'ouvrage de IKENBERRY (G. John) : Power, Order, and Change in World Politics
Wintgens, Sophie ULg

in Revue Française de Science Politique (in press), 65(3), 494-495

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See detailTien Shan geohazards database: Earthquakes and landslides
Havenith, Hans-Balder ULg; Strom, Alexander; Torgoev, Isakbek et al

in Geomorphology (in press)

In this paper we present new and review already existing landslide and earthquake data for a large part of the Tien Shan, Central Asia. For the same area, only partial databases for sub-regions have been ... [more ▼]

In this paper we present new and review already existing landslide and earthquake data for a large part of the Tien Shan, Central Asia. For the same area, only partial databases for sub-regions have been presented previously. They were compiled and new data were added to fill the gaps between the databases. Major new inputs are products of the Central Asia Seismic Risk Initiative (CASRI): a tentative digital map of active faults (even with indication of characteristic or possible maximum magnitude) and the earthquake catalogue of Central Asia until 2009 that was now updated with USGS data (to May 2014). The new compiled landslide inventory contains existing records of 1600 previously mapped mass movements and more than 1800 new landslide data. Considering presently available seismo-tectonic and landslide data, a target region of 1200 km (E–W) by 600 km (N–S) was defined for the production of more or less continuous geohazards information. This target region includes the entire Kyrgyz Tien Shan, the South-Western Tien Shan in Tajikistan, the Fergana Basin (Kyrgyzstan, Tajikistan and Uzbekistan) as well as the Western part in Uzbekistan, the North-Easternmost part in Kazakhstan and a small part of the Eastern Chinese Tien Shan (for the zones outside Kyrgyzstan and Tajikistan, only limited information was available and compiled)... [less ▲]

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See detailCongenital jaundice in bovine aborted fetuses: an emerging syndrome in Southern Belgium
Delooz; Mori, M; Petitjean, T et al

in Transboundary and Emerging Diseases (in press)

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See detailDiversity of germination strategies and dormancy of graminoid and forb species of campo rupestre grasslands
Le Stradic, Soizig ULg; Silveira, Fernando A. O.; Buisson, Elise et al

in Austral Ecology (in press)

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See detailUn type picard par-delà les frontières : le <nom jeté>
Baiwir, Esther ULg

in Dialectes de Wallonie (in press), 36

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See detailActive Management of Low-Voltage Networks for Mitigating Overvoltages due to Photovoltaic Units
Olivier, Frédéric ULg; Aristidou, Petros ULg; Ernst, Damien ULg et al

in IEEE Transactions on Smart Grid (in press)

In this paper, the overvoltage problems that might arise from the integration of photovoltaic panels into low-voltage distribution networks is addressed. A distributed scheme is proposed that adjusts the ... [more ▼]

In this paper, the overvoltage problems that might arise from the integration of photovoltaic panels into low-voltage distribution networks is addressed. A distributed scheme is proposed that adjusts the reactive and active power output of inverters to prevent or alleviate such problems. The proposed scheme is model-free and makes use of limited communication between the controllers, in the form of a distress signal, only during emergency conditions. It prioritizes the use of reactive power, while active power curtailment is performed only as a last resort. The behavior of the scheme is studied using dynamic simulations on a single low-voltage feeder and on a larger network composed of 14 low-voltage feeders. Its performance is compared to a centralized scheme based on the solution of an Optimal Power Flow problem, whose objective function is to minimize the active power curtailment. The proposed scheme successfully mitigates overvoltage situations due to high photovoltaic penetration and performs almost as well as the Optimal Power Flow based solution with significantly less information and communication requirements. [less ▲]

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See detailDrivers of the winter–spring phytoplankton bloom in a pristine NW Mediterranean site, the Bay of Calvi (Corsica): A long-term study (1979–2011)
Goffart, Anne ULg; Hecq, Jean-Henri ULg; Legendre, Louis

in Progress in Oceanography (in press)

This work is based on a long time series of data collected in the well-preserved Bay of Calvi (Corsica island, Ligurian Sea, NW Mediterranean) between 1979 and 2011, which include physical characteristics ... [more ▼]

This work is based on a long time series of data collected in the well-preserved Bay of Calvi (Corsica island, Ligurian Sea, NW Mediterranean) between 1979 and 2011, which include physical characteristics (31 years), chlorophyll a (chl a, 15 years), and inorganic nutrients (13 years). Because samples were collected at relatively high frequencies, which ranged from daily to biweekly during the winter-spring period, it was possible to (1) evidence the key role of two interacting physical variables, i.e. water temperature and wind intensity, on nutrient replenishment and phytoplankton dynamics during the winter-spring period, (2) determine critical values of physical factors that explained interannual variability in the replenishment of surface nutrients and the winter-spring phytoplankton bloom, and (3) identify previously unrecognized characteristics of the planktonic ecosystem. Over the >30 year observation period, the main driver of nutrient replenishment and phytoplankton (chl a) development was the number of wind events (mean daily wind speed >5 m s-1) during the cold-water period (subsurface water ≤13.5°C). According to winter intensity, there were strong differences in both the duration and intensity of nutrient fertilization and phytoplankton blooms (chl a). The trophic character of the Bay of Calvi changed according to years, and ranged from very oligotrophic (i.e. subtropical regime, characterized by low seasonal variability) to mesotrophic (i.e. temperate regime, with a well-marked increase in nutrient concentrations and chl a during the winter-spring period) during mild and moderate winters, respectively. A third regime occurred during severe winters characterized by specific wind conditions (i.e. high frequency of northeasterly winds), when Mediterranean “high nutrient - low chlorophyll” conditions occurred as a result of enhanced cross-shore exchanges and associated offshore export of the nutrient-rich water. There was no long-term trend (e.g. climatic) in either nutrient replenishment or the winter-spring phytoplankton bloom between 1979 and 2011, but both nutrients and chl a reflected interannual and decadal changes in winter intensity. [less ▲]

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See detailReduced Order Analysis of Aeroelastic Systems with Freeplay using an Augmented Modal Basis
Silva, Gustavo H. C.; Dal Ben Rossetto, Gustavo; Dimitriadis, Grigorios ULg

in Journal of Aircraft (in press)

Freeplay in aircraft control surface actuators is a common source of nonlinearity that can cause undesirable aeroelastic phenomena and, as a consequence, certification authorities place strict limits on ... [more ▼]

Freeplay in aircraft control surface actuators is a common source of nonlinearity that can cause undesirable aeroelastic phenomena and, as a consequence, certification authorities place strict limits on the size of the deadband gaps of actuators. In recent years many authors have worked on determining the effects of freeplay on the dynamic behavior of aeroelastic systems; these efforts have yielded significant improvements in the understanding of the phenomena, but have concentrated on simple models. Investigations of industry-relevant aeroelastic models of complete aircraft with freeplay in the actuators have been much rarer, the main difficulty being the selection of an appropriate modal basis that can represent the full range of possible dynamic phenomena. This work presents a novel implementation of the residual vectors approach to create consistent and numerically stable reduced order models suitable for industrial-standard aeroelastic models of aircraft. The methodology relies on the piecewise linear nature of freeplay to create a single reduction basis that represents the dynamics of the system both inside and outside the freeplay deadband gap. The method is demonstrated on an Embraer generic test bench aircraft, showing that the resulting reduced order model is efficient and effective. Nonlinear analysis is carried out using equivalent linearization as well as time integrations of the full nonlinear system. It is shown that, while equivalent linearization is an indispensable tool for a preliminary mapping of the main aeroelastic instabilities, the time integration-based nonlinear analysis is an essential complementary tool to confirm the characteristics of the system behavior. [less ▲]

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See detailState Created Barriers to Exit - The Example of the Acquisition of Alstom by General Electric
Petit, Nicolas ULg

in Competition Policy International (in press)

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See detailAn analysis of potential resistance of the phytophagous mite, Tetranychus urticae (Tetranychidae) to four botanical pesticides
Attia, Sabrine; Lebdi, KL; Heuskin, Stéphanie ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

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See detailImmune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation following Flu-TBI versus TLI-ATG Conditioning
HANNON, Muriel ULg; BEGUIN, Yves ULg; Ehx, Grégory ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (in press)

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft ... [more ▼]

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft-versus-tumor effects without graft-versus-host disease (GVHD). Experimental Design: We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n=28) or 8 Gy TLI plus anti-thymocyte globulin (TLI arm, n=25). Results: In comparison to TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P=0.02), a higher incidence of CMV reactivation (P<0.001), and a higher incidence of relapse (P=0.01). While recovery of total CD8+ T cells was similar in the two groups, with median CD8+ T cell counts reaching the normal values 40-60 days after allo-HCT, TLI patients had lower percentages of naïve CD8 T cells. Median CD4+ T cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Further, CD4+ T cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, while median absolute regulatory T cell (Treg) counts were comparable in TBI and TLI patients, Treg/naïve CD4+ T cell ratios were significantly higher in TLI than in TBI patients the 2 first years after transplantation. Conclusions: Immune recovery differs substantially between these two conditioning regimens possibly explaining the different clinical outcomes observed (NCT00603954). [less ▲]

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See detailL'école liégeoise de physiologie aux 19e et 20e siècles
Geenen, Vincent ULg

in Histoire des Sciences Médicales (in press)

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See detailAnalytical Procedure Validation and the Quality by Design Paradigm
Rozet, Eric ULg; Rozet, Eric

in Journal of Biopharmaceutical Statistics (in press)

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedure that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modelling and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure Design Space and from it, control strategy can be set. [less ▲]

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See detailLaser cladding as repair technology for Ti6Al4V alloy: Influence of building strategy on microstructure and hardness
Paydas, Hakan ULg; Mertens, Anne ULg; Carrus, Raoul et al

in Materials & Design (in press)

Laser cladding is a metal deposition technique used to fabricate or repair components made from high value metallic alloys. In the present work Ti-6Al-4V deposits with variable thickness are made to ... [more ▼]

Laser cladding is a metal deposition technique used to fabricate or repair components made from high value metallic alloys. In the present work Ti-6Al-4V deposits with variable thickness are made to assess the use of laser cladding as a repair technology. Both the effect of the building strategy (BS) and the incident energy (IE) on the metallurgical characteristics of the deposits in relation to their complex thermal history have been studying. It is shown that for the configuration consisting in a decreasing track length (DTL) under high IE, a gradient of cooling rate exists that leads to the presence of different phases within the microstructure. Conversely homogeneous microstructures are present either for the configuration with a constant track length (CTL) under high IE, and for the strategy obtained from a DTL under low IE. Depending on the possible heat accumulation the nature of the phases are determined together with hardness maps within the deposits. Some qualification criteria are set prior to tensile tests to selected the adequate candidate-deposit that does not weaken the cladded material when it is stressed. A thermo-metallurgical scheme is proposed that helps understanding the effect of both the BS and the IE on the microstructure. [less ▲]

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See detailA new understanding of psychopathy: The contribution of phenomenological psychopathology
Englebert, Jérôme ULg

in Psychopathology (in press)

The objective of this study is to present a theoretical paper about a clinical issue. Our aim is to propose some clinical and semiological considerations for a psychopathological conception of psychopathy ... [more ▼]

The objective of this study is to present a theoretical paper about a clinical issue. Our aim is to propose some clinical and semiological considerations for a psychopathological conception of psychopathy. We will discuss several major theoretical works dedicated to this nosographic entity (mainly those of Schneider, Cleckley and Hare). We will also examine a significant issue raised by Cooke et al., namely whether psychopathic functioning is consistently related to antisocial behavior. This theoretical essay is informed by clinical situations (involving psychopaths who were interviewed in prison or in forensic centers). The method applied a phenomenological psychopathology analysis to the clinical material. We first compare Binswanger’s conception of mania with psychopathic functioning. Patients’ behavior is similar but there is a difference related to the dialectic between the ego and the alter ego. A patient with mania has a fundamental crisis of the ego, which a psychopath does not have. A second finding of our investigations concerns emotions and the adaptive dimension of the psychopathic disorder. An epistemological discussion of the concept of emotions reveals that psychopaths are competent in the management of emotional stimuli, which confers a psychological advantage upon them. [less ▲]

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See detailDesign of hybrid nanovehicles for remotely triggered drug release: an overview
Liu, Ji; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Materials Chemistry B (in press)

n the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote ... [more ▼]

n the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote stimuli, e.g. alternating magnetic field, near infrared or ultrasound radiations, the release of guest molecules can be triggered in a quite controlled manner. Herein, we review different hybrid nanostructures which have already been reported for the remotely triggered release, such as those based on (1) host–guest conjugates, (2) core–corona nanoparticles, (3) polymer nanogels, (4) polymer micelles, (5) liposomes, (6) mesoporous silica particles and (7) hollow nanoparticles. Moreover, we also summarize six underlying mechanisms that govern such a kind of remotely triggered release behaviours: (1) enhanced diffusion and/or permeation, (2) thermo- or photo-labile bond cleavage, (3) fusion of phase-changed materials, (4) photo-induced isomerisation, (5) thermo-induced swelling/de-swelling of thermo-responsive polymers, and (6) destruction of the nanostructures. The ways in which different components are incorporated into an integrated hybrid nanostructure and how they contribute to the remotely triggered release behaviours are detailed. [less ▲]

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See detailNGOs and female circumcision in Egypt. An anthropological enquiry.
Mescoli, Elsa ULg

in Journal of the Anthropology of the Contemporary Middle East and Central Eurasia (in press)

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the ... [more ▼]

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the circumcision of a ten-year-old child living in this very same city. Discourses around female circumcision were not new in Egypt and in the international community, but what was considered as a new episode of a recurrent scandal (not the last one indeed) led to enhance the "war against bad government"[1]. A war fought by means of ideological weapons produced by expert knowledges among which the medical and the feminist ones. The assignment of a value to the state of integrity of the female body and to the women freedom of choice, both designed according to Western canons, led to different actions to “save” Egyptian women. In this context, development agencies fosters a widespread representation of the victim, constituted by the woman mutilated body. Such representation is functional to put in place programs which do not guarantee a freedom of choice, but rather require adherence to another female model, one that defines the "modern" woman. My article, based on ethnographic experience, aims at highlighting the complexity of such dynamics and the role played by humanitarianism within them. Female body becomes the arena where local and international economic powers operate, disregarding a real understanding of the practice, its meanings and its eventual change. ________________________________________ [1] Foucault, Michel. La nascita della clinica. Il ruolo della medicina nella costituzione delle scienze umane, Einaudi, Torino 1969: 48. [less ▲]

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See detailLes recettes de l’Autre. De la transmission des savoirs (et savoir-faire) féminins en contexte migratoire.
Mescoli, Elsa ULg

in Hommes & Migrations (in press)

La plupart des études sur la connexion entre alimentation et migration sont assez récentes. Elles mettent tout d’abord en évidence le fait que, lors d’un déplacement, les individus ou les groupes sont ... [more ▼]

La plupart des études sur la connexion entre alimentation et migration sont assez récentes. Elles mettent tout d’abord en évidence le fait que, lors d’un déplacement, les individus ou les groupes sont confrontés à des styles alimentaires différents. Ces recherches s’engagent alors à vérifier dans quelle mesure cette rencontre défie l’identité individuelle (Cardona, 2004; Crenn, 2004; Spiro, 1955) et quelles pratiques elle engage afin de la préserver (Hage, 1997; Beyers, 2008; Diner and Diner, 2009). L’attention est ainsi portée au contexte domestique dans lequel les familles issues de la migration préparent leurs repas et, potentiellement, définissent leur appartenance culturelle. Une deuxième direction entreprise par ces études, concerne par contre l’espace public : par exemple, les ainsi dits « restaurants ethniques » font l’objet de nombreuses recherches qui visent cette fois à analyser la consommation de l’ « exotique » de la part des membres de la population majoritaire (Hassoun & Raulin, 1995; Régnier, 2005). Ces deux dimensions principales sont rarement abordées dans leur superposition, fait qui laisse dans l’ombre des dynamiques pareillement pertinentes. Notamment, nous pourrions relever les enjeux liés à la préparation de nourriture conçue comme pratique du quotidien destinée à être exportée en contexte non-domestique et offerte à des individus qui, non seulement ne font pas partie de la famille de ceux qui cuisinent, mais sont aussi associés à une appartenance culturelle différente. L’étude de ces enjeux amène à constater que la définition active de soi au travers de la pratique culinaire s’entremêle à la volonté d’en transmettre une image aux autres. En particulier, lorsqu’on adopte une perspective de genre et que l’on focalise l’attention sur les femmes migrantes, nous sommes amenés à noter comment un de ces savoir-faire qui constituent des potentiels dispositifs de domestication (Rogers, 1981) se transforme en instrument de visibilité, et ainsi de participation, dans l’espace public. Dans cet article, afin de mettre en évidence la complexité de ces dynamiques, je présenterai en clef comparative des exemples collectés dans le cadre de mes recherches autour du lien entre alimentation et migration. J’analyserai les pratiques culinaires exercées en contexte public d’un côté par un groupe de femmes marocaines résidentes en Italie, de l’autre par certaines femmes italiennes résidentes en Belgique. La comparaison des choix des femmes, faits en fonction des destinataires mais aussi en réponse aux différents contextes sociopolitiques dans lesquels certaines manifestations culinaires prennent la forme de « rencontres interculturelles », permettra de donner un aperçu sur la façon dont les femmes considérées s’assurent une place active dans l’espace vécu. Le texte sera illustré par des images collectées durant l’ethnographie. [less ▲]

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See detailWorking memory deficits in developmental dyscalculia: the importance of serial order.
Attout, Lucie ULg; Majerus, Steve ULg

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (in press)

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (in press)

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailMinor compounds and oxidative stability of mono-varietal virgin olive oils produced in eastern of Morocco
Mansouri, Farid; Benmoumen, Abdessamad; Richard, Gaetan ULg et al

in Food Chemistry (in press)

The aim of this study is to characterize monovarietal virgin olive oils (VOOs) of new high-density plantings system of three cultivars (Arbequina, Arbosana and Koroneiki) which have been recently ... [more ▼]

The aim of this study is to characterize monovarietal virgin olive oils (VOOs) of new high-density plantings system of three cultivars (Arbequina, Arbosana and Koroneiki) which have been recently introduced in the eastern mediterranean region of Morocco. In this study, we have also conducted comparison between those monovarietal VOOs and olive oil of the local olive cultivar Picholine marocaine. Monovarietal VOOs characterization has been carried out by analysing several parameters, including quality index and olive oil stability to oxidation. Significant differences between the analysed olive oils were highlighted. They depend on cultivars and technological conditions of processing. We have noticed that Koroneiki olive oil have higher content of phenols (459.48 mg kg-1) and have the best value of oxidative stability (93.16 h). On the other hand Arbrosana’s VOO has low content of total phenols (260.85 mg kg-1) but it was distinguished by its higher content of alpha-tocopherol (460.07 mg kg-1). In addition, ten phenolic compounds present in virgin olive oils, were identified and quantitatively assessed by HPLC. Hydroxytyrosol, tyrosol, luteoline, pinoresinol and apigenin were the main phenolic compounds in those analyzed monovarietal VOOS. [less ▲]

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See detailComique et didactique : le rire en classe de langue ?
Defays, Jean-Marc ULg

in Vivre le Français : Revue de l'Association Belge des Professeurs de Français (in press), 245

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See detailGlycine receptors control the generation of projection neurons in the developing cerebral cortex
Avila, Ariel; Vidal, P.M.; Tielens, Sylvia ULg et al

in Cell Death & Differentiation (in press)

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See detailLa question du diagnostic en psychiatrie infanto-juvénile
de Becker, Emmanuel; François, Anne; Kinoo, Philippe et al

in Psychiatrie de l'Enfant (La) (in press)

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi ... [more ▼]

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi que les multiples échanges entre professionnels concernés. Le diagnostic pédopsychiatrique est un processus dynamique, modifiable et momentané, les organisations pathologiques étant pour la plupart en transformation permanente. De manière spécifique et en fonction du processus développemental, la thématique du diagnostic en pédopsychiatrie renvoie plus à la question du risque évolutif qu’à la question d’un état pathologique en soi. Les aspects de la continuité des troubles mentaux de l’enfance à l’âge adulte représentent en effet un véritable enjeu développemental. Deux points de vue s’opposent dans la littérature. Le premier, en lien avec un prédéterminisme, estime que les trajectoires sont toutes tracées, l’incertitude reposant dans le diagnostic ; concrètement, il s’agit de repérer de manière précoce des individus à risque parce qu’ils sont porteurs d’un trouble qu’il faut traiter. Le second point de vue considère que les trajectoires ne sont pas déterminées mais sont en réécriture permanente ; ici, le risque ne se situe plus au niveau du diagnostic mais du pronostic, dans un souci de prévention et non de prédiction. L’article propose les réflexions de quatre cliniciens psychiatres infanto-juvéniles sur cette thématique, à la lumière de leur pratique et de leurs échanges. [less ▲]

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See detailShort communication: Evaluation of the microbiota of kefir samples using metagenetic analysis targeting the 16S and 26S ribosomal DNA fragments
Korsak Koulagenko, Nicolas ULg; Taminiau, Bernard ULg; Leclercq, Mathilde et al

in Journal of Dairy Science (in press)

Milk kefir is produced by fermenting milk in the presence of kefir grains. This beverage has several benefits for human health. The aim of this experiment was to analyze 5 kefir grains (and their products ... [more ▼]

Milk kefir is produced by fermenting milk in the presence of kefir grains. This beverage has several benefits for human health. The aim of this experiment was to analyze 5 kefir grains (and their products) using a targeted metagenetic approach. Of the 5 kefir grains analyzed, 1 was purchased in a supermarket, 2 were provided by the Ministry of Agriculture (Namur, Belgium), and 2 were provided by individuals. The metagenetic approach targeted the V1-V3 fragment of the 16S ribosomal (r)DNA for the grains and the resulting beverages at 2 levels of grain incorporation (5 and 10%) to identify the bacterial species population. In contrast, the 26S rDNA pyrosequencing was performed only on kefir grains with the aim of assessing the yeast populations. In parallel, pH measurements were performed on the kefir obtained from the kefir grains using 2 incorporation rates. Regarding the bacterial population, 16S pyrosequencing revealed the presence of 20 main bacterial species, with a dominance of the following: Lactobacillus kefiranofaciens, Lactococcus lactis ssp. cremoris, Gluconobacter frateurii, Lactobacillus kefiri, Acetobacter orientalis, and Acetobacter lovaniensis. An important difference was noticed between the kefir samples: kefir grain purchased from a supermarket (sample E) harbored a much higher proportion of several operational taxonomic units of Lactococcus lactis and Leuconostoc mesenteroides. This sample of grain was macroscopically different from the others in terms of size, apparent cohesion of the grains, structure, and texture, probably associated with a lower level of Lactobacillus kefiranofaciens. The kefir (at an incorporation rate of 5%) produced from this sample of grain was characterized by a lower pH value (4.5) than the others. The other 4 samples of kefir (5%) had pH values above 5. Comparing the kefir grain and the kefir, an increase in the population of Gluconobacter in grain sample B was observed. This was also the case for Acetobacter orientalis in sample D. In relation to 26S pyrosequencing, our study revealed the presence of 3 main yeast species: Naumovozymaspp., Kluyveromyces marxianus, and Kazachastania khefir. For Naumovozyma, further studies are needed to assess the isolation of new species. In conclusion, this study has proved that it is possible to establish the patterns of bacterial and yeast composition of kefir and kefir grain. This was only achieved with the use of high-throughput sequencing techniques. [less ▲]

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See detailFinancement de la santé et recouvrement des coûts : le lourd fardeau des ménages congolais. Résultats des comptes nationaux de la santé.
Manzambi Kuwekita, Joseph ULg; Eloko Eya Matangelo, Gérard; Bruyère, Olivier ULg et al

in Journal d’Épidémiologie et de Santé Publique (in press)

This study examines the share and allocation of household expenditure in health financing, as presented by the National Health Account figures. These figures are based on a national survey carried out in ... [more ▼]

This study examines the share and allocation of household expenditure in health financing, as presented by the National Health Account figures. These figures are based on a national survey carried out in 2010 among 11,000 households, 2,200 people living with HIV/AIDS, 183 institutions, 42 mutual funds, 18 companies and using the balance sheets of 1,300 companies. Total household health expenditure per capita per year amounted to U.S. $ 4.50. Routine health expenditure is covered by the households (40%) and international cooperation (45%) through direct payment without cost sharing (93.7%). A hospital stay is warranted in case of nutritional deficiencies (34%), malaria (12%) and mental disorders (10%). 82% of outpatient care is related to malaria (71%) and mental disorders (12.5 %). In conclusion, the observation that 71.58% of hospitals expenditure, 96.49% of ambulatory care centres expenditure, 98.48% of medical and diagnosis laboratories expenditure, 72.42% of pharmacies expenditures come from households’ out of pocket expenses calls for the establishment of solidarity mechanisms in the health sector. Outpatient malaria care consumes as much as 71% of household expenditure, and we therefore need to strengthen prevention, treatment and focus on monitoring progress. The fact that nutritional deficiencies are the leading cause of people seeking hospital care suggests that efforts are needed to improve their living conditions of households. Mental disorders are the third leading cause of hospital recourse and this pathology should therefore be included in the minimum and supplementary package of activities. [less ▲]

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See detailThe “Belgian Tetris”: Assessing the political impact of metaphors on citizens’ representations of Belgian federalism
Perrez, Julien ULg; Reuchamps, Min

in Metaphor and the Social World (in press)

Based on the idea that metaphors do not only reflect the perceived reality, but also function as cues through which citizens come to understand complex political processes, the aim of this study is to ... [more ▼]

Based on the idea that metaphors do not only reflect the perceived reality, but also function as cues through which citizens come to understand complex political processes, the aim of this study is to look at how specific metaphors might impact on the citizens' framing of Belgian federalism. To measure the impact of metaphors on the citizens' political representations, we conducted an experiment among 493 citizens based on an article published in the newspaper Le Soir in which Belgian federalism was compared to a Tetris game in both a text and an image. The participants were distributed into four experimental conditions according to the type of input they had been exposed to (text and image, text only, image only, no input) and were asked to perform a free description task. The productions of the participants were analyzed using keyword analyses and content analyses. The results suggest that the participants who had been exposed to the experimental text tend to differently frame their perception of Belgian federalism. These results show that reading the text, more than looking at the image, has an impact on the representations of the citizens but that this impact is short-lived. [less ▲]

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See detailDe Rome à Wilderen : Alexandre Ier et Raoul de Saint-Trond
Schmidt, Kevin ULg

in Revue Belge de Philologie et d'Histoire (in press)

While Rudolf, the abbot of Sint-Truiden (1108-1138) was forced to abandon his monastery in 1121 after having opposed the claim to power of the future prince-bishop of Liège, Alexandre I (1128-1135), both ... [more ▼]

While Rudolf, the abbot of Sint-Truiden (1108-1138) was forced to abandon his monastery in 1121 after having opposed the claim to power of the future prince-bishop of Liège, Alexandre I (1128-1135), both men hastily set out for Rome on the eve of 1129, in order to meet Pope Honorius the Second. The Gesta abbatum Trudonensium have preserved this colorful account of the perilous circumstances under which they crossed the Great St. Bernard Pass together in full winter. Starting from this particular anecdote, the document, which recounts the evolving personal relationship between the bishop of Liège, Alexandre I and abbot Rudolf of Sint-Truiden, returns to the circumstances surrounding this surprising rapprochement, which came to pass against all expectations. It seeks to demonstrate that Rudolf of Sint-Truiden’s motivations to accompany his former enemy to Italy were political rather than spiritual. [less ▲]

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See detailInhibitory deterioration may contribute to hallucinations in Alzheimer’s disease
El Haj, Mohamad; Laroi, Frank ULg; Gély-Nargeot, Marie-Christine et al

in Cognitive Neuropsychiatry (in press)

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See detailDélinquance des adolescents et maturation pubertaire analysées au travers du timing pubertaire perçu
Glowacz, Fabienne ULg; Bourguignon, Jean-Pierre ULg

in Annales Médico-Psychologiques (in press)

The impact of pubertal development on the psychological and social functioning of the teenager arouses a particular interest; the most recent research shows the existence of complex relationships between ... [more ▼]

The impact of pubertal development on the psychological and social functioning of the teenager arouses a particular interest; the most recent research shows the existence of complex relationships between pubertal development and the manifestation of internalized and externalized disorders. Two predominant hypothesis are used for explain influence of pubertal timing on problem behaviors : the maturational deviance theory and the stage termination (early timing) theory. The deviance theory claims that the borderline or abnormal pubertal timing, whether early or late, causes difficulties for adolescent adaptation. The early timing theory suggests that early pubertal timing and the consequent early physical maturation put adolescents at greater risk of adjustment problems because early pubertal maturation interferes with normal progression through the developmental tasks of adolescence. Our study is interested specifically in the links between delinquency during adolescence and pubertal maturation in a population of 141 boys aged between 12 and 18. We measured the pubertal variable starting from the perceived pubertal timing (PPT), which evaluates the teenagers' perception of their pubertal maturation, compared with that of their peers, to understand its impact on various dimensions of the functioning of teenagers: the self-perception (scale of Harter), aggressiveness (scale of Buss and Perry), association with peers and self-reported delinquency (attacks on property and individuals). We began with univariate analyses in order to determine the variables associated with early or late pubertal timing through comparison of scores obtained in those subjects with reference to average maturers. Subsequently, multivariate analyses were used in an attempt to sort out which among the studied factors could be predictor or a determinant of delinquency in relation to pubertal timing. Therefore, stepwise multiple regression analysis was performed. Statistical analyses were run with the SAS software, version 9.1.Our results support the thesis of precocity, the teenagers with an advanced PPT present scores of delinquency and aggressiveness significantly higher than teenagers with a standard PPT. However, the sub-group of teenagers with delayed PPT present raw scores of self-revealed delinquency which are higher than those of teenagers with a standard PPT. These teenagers can be characterized by a significantly higher hostility than the teenagers with a standard PPT. This cognitive dimension of aggressiveness, as evaluated by Buss and Perry, characterizes the functioning of the teenagers with the delayed PPT, who also present poorer self-esteem and dissatisfaction with their physical appearance. On the basis of this assessment, an analysis of multiple regression within each type of PPT aimed at identifying the variables likely to explain the delinquency of teenagers according to their PPT. The results show that the physical factor of aggressiveness is common to the three types of PPT. It is associated with the affiliation with delinquent peers for those teenagers with advanced and normal PPT, whereas for those teenagers with delayed PPT, it interacts with the factor of hostility, which is specific to them. Association with delinquent peers recognized as a major risk factor and predictive for the self-revealed delinquency of teenagers in general does not intervene for these boys who perceive their pubertal development late, compared to the others. The delinquency of teenagers with a delayed PPT cannot be explained by the factors that are considered in the general population, their social functioning and the socialization of these teenagers with delayed puberty is different from that of the other teenagers, as is their implication in delinquency, which is not explained by a kind of socialization with delinquent peers. These results confirm the importance of integrating the puberty variable into research on delinquency, but also at the level of intervention. [less ▲]

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See detailClinical pharmacology of antifungal agents to overcome drug resistance in pediatric patients
STERGIOPOULOU, Theodouli ULg; Walsh, Thomas J.

in Expert opinion on pharmacotherapy (in press), 16(2), 213-26

INTRODUCTION: Antifungal resistance is an emerging problem that increases morbidity and mortality in immunosuppressed pediatric patients, who suffer from invasive fungal diseases. Optimal pharmacological ... [more ▼]

INTRODUCTION: Antifungal resistance is an emerging problem that increases morbidity and mortality in immunosuppressed pediatric patients, who suffer from invasive fungal diseases. Optimal pharmacological management is critical for the successful treatment of invasive fungal infections by resistant strains. AREAS COVERED: This paper reviews the mechanisms of resistance of different classes of antifungal agents and the current understanding of pediatric antifungal pharmacology for overcoming antifungal resistance in children based on laboratory and clinical studies in the English literature. The therapeutic choices against fungal pathogens with intrinsic or acquired resistance are further reviewed. EXPERT OPINION: There is a paucity of data in the pediatric population regarding the epidemiology of the resistant organisms to different antifungal agents. It is also unknown if there are more prevalent molecular mechanisms that promote antifungal resistance. Selection and dosages of the most effective antifungal agent for overcoming the antifungal resistance is crucial. However, there are limited studies guiding the optimal dosage and duration of treatment for management of emergent antifungal resistance. Further studies are warranted to elucidate the optimal pharmacology of the current antifungal agents against resistant organisms and to advance the development of new antifungal agents. [less ▲]

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See detailWhy is later age at retirement beneficial for cognition? Results from a French population-based study
Grotz, Catherine ULg; Meillon, Céline; Amieva, Hélène et al

in Journal of Nutrition, Health & Aging (in press)

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See detailExploratory Single Grain OSL data analysis of quartz from archeological mortars: on the use of an exponential distribution of light exposure of grains and consequences for dating
Guibert, Pierre; Urbanova, Petra; Blain, Sophie ULg et al

in Radiation Measurements (in press)

Dating archaeological mortar by OSL is one of the challenging objectives leading to the chronology of ancient constructions. Single grain OSL analysis is a very convenient tool to examine the bleaching ... [more ▼]

Dating archaeological mortar by OSL is one of the challenging objectives leading to the chronology of ancient constructions. Single grain OSL analysis is a very convenient tool to examine the bleaching state of the series of quartz grains extracted from a mortar sample. Indeed, during the making process, sand is extracted from a sedimentary source, transported, stored then mixed with lime and set into the walls being constructed. Experience shows that incomplete bleaching is frequent for these materials. The aim of this study is to model the distribution of single grain equivalent doses of mortars following the assumption that a population of grains corresponds to a unique distribution of heterogeneously bleached grains rather than to a mixture of well bleached quartz grains with poorly bleached ones. An exponential distribution of light exposure of grains is examined. By comparing experimental distributions of doses with simulated ones, we investigate the appropriateness of this distribution function and then we calculate the average residual dose integrated into the process of the ED determination and finally the OSL age. Limits and potentials of this approach are discussed using various case-studies of structures and buildings of known age (from the roman to the post-medieval period). Even in case of very poorly bleached samples we observed that the simulated ED distribution fits satisfactorily with the experimental one, which offers new encouraging perspectives in single grain dating of mortars. [less ▲]

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See detailVanadium fine-structure K-shell electron impact ionization cross sections for fast-electron diagnostic in laser-solid experiments
Palmeri, P; Quinet, Pascal ULg; Batani, D

in Atomic Data & Nuclear Data Tables (in press)

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See detailPractical management of Chronic Myeloid Leukemia in Belgium
Benghiat, FS.; Beguin, Yves ULg; Dessars, B. et al

in Belgian Journal of Hematology (in press)

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation ... [more ▼]

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation tyrosine kinase inhibitors (TKIs) and the possibility of treatment discontinuation made the management of these patients more challenging. In this review, practical management guidelines of CML are presented, adapted to the Belgian situation in 2014. In first line chronic phase patients, imatinib, nilotinib and dasatinib can be prescribed. While second generation TKIs give faster and deeper responses, their impact on long-term survival remain to be determined. The choice of the TKI depends on CML risk score, priority for a deep response to allow a treatment-free remission protocol, age, presence of comorbid conditions, side effect profile, drug interactions, compliance concerns and price. Monitoring the response has to be made according the 2013 ELN criteria, and is based on the bone-marrow cytogenetic response during the first months and on the blood molecular response. Molecular follow-up is sufficient in patients with a complete cytogenetic response. For patients who fail frontline therapy, nilotinib, dasatinib, bosutinib and ponatinib are an option depending of the type of intolerance or resistance. T315I patients are only sensitive to ponatinib, which has to be carefully handled due to cardiovascular toxicity. Advanced phase diseases are more difficult to handle, with treatments including allogeneic stem cell transplantation, which is also an option for patients failing at least two TKIs. The possibility of treatment-free remission and pregnancy are also discussed. [less ▲]

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See detailImbalance between oxygen photoreduction and antioxidant capacities in Symbiodinium cells exposed to combined heat and high light stress
Roberty, Stéphane ULg; Fransolet, David; Cardol, Pierre ULg et al

in Coral Reefs (in press)

During last decades coral reefs have been affected by several large-scale bleaching events and such phenomenon is expected to increase in frequency and severity in the future thus compromising their ... [more ▼]

During last decades coral reefs have been affected by several large-scale bleaching events and such phenomenon is expected to increase in frequency and severity in the future thus compromising their survival. High sea surface temperature accompanied by high levels of solar irradiance has been found to be responsible for the induction of an oxidative stress ultimately ending with the disruption of the symbiosis between cnidarians and Symbiodinium. Since two decades many studies have pointed out the water-water cycle as being one of the primary mediators of this phenomenon, but the impacts of environmental stress on the O2 reduction by PSI and the associated ROS-detoxifying enzymes remain to be determined. In this study, we analyzed the impacts of an acute thermal and light stress on the WWC in the model Symbiodinium strain A1. We observed that high light treatment at 26°C resulted in the up-regulation of superoxide dismutase (SOD), ascorbate peroxidase (APX) and glutathione reductase (GR) activities and an increased production of Reactive Oxygen Species (ROS) with no significant change in O2-dependent electron transport. Under high light and at 33°C, O2-dependent electron transport was significantly increased relative to total electron transport. This increase was concomitant with a two-fold increase in ROS generation compared to the treatment at 26°C, while enzymes involved in the WWC were largely inactivated. These data show for the first time that combined heat and light stress inactivate antioxidant capacities of the WWC, and suggests that its photoprotective functions are overwhelmed under these conditions. This study also indicates that cnidarians may be more prone to bleach if they harbor Symbiodinium cells having a highly active Mehler-type electron transport, unless they are able to quickly up-regulate their antioxidant capacities. [less ▲]

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See detailcompte rendu de : James Noel ADAMS, Social Variation and the Latin Language
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (in press)

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See detailPhysiological and bio-functional properties of gum arabic: a notable interest for certain human diseases
Eloundou Mballa, Pierre; Goffin, Dorothée ULg; Destain, Jacqueline ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

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See detailRaman characterization of the UV-protective pigment gloeocapsin and its role in the survival of cyanobacteria
Storme, Jean-Yves ULg; Golubic, Stjepko; Wilmotte, Annick ULg et al

in Astrobiology (in press)

Extracellular UV-screening pigments gloeocapsin and scytonemin present in the EPS envelopes of extremophile cyanobacteria of freshwater and marine environments were studied by Raman spectroscopy and ... [more ▼]

Extracellular UV-screening pigments gloeocapsin and scytonemin present in the EPS envelopes of extremophile cyanobacteria of freshwater and marine environments were studied by Raman spectroscopy and compared to their intracellular photosynthetic pigments. This Raman spectral analysis of the extracellular pigment gloeocapsin showed that it shared Raman spectral signatures with parietin, a radiation-protective pigment known in lichens. The UV-light spectra also showed similarities. Gloeocapsin occurs in some cyanobacterial species, mostly with exclusion of scytonemin, indicating that these pigments have evolved in cyanobacteria as separate protective strategies. Both gloeocapsin and scytonemin are widely and species-specifically distributed in different cyanobacterial genera and families. The widespread occurrence of these pigments may suggest an early origin, while their detection by Raman Spectroscopy makes them potential biosignatures for cyanobacteria in the fossil record and demonstrates the usefulness of non-destructive Raman spectroscopy analyses for the search of complex organics, including possible photosynthetic pigments, if preservable in early Earth and extraterrestrial samples. [less ▲]

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See detailCompte rendu de l'ouvrage de Frédéric MARCHESANI, Sur les traces des anciens "pays" de Wallonie
George, Philippe ULg

in Trésor de Liège. Bulletin trimestriel (in press)

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See detailL'éveil de la matrix-gla-protéine sonnera le glas des calcifications vasculaires
DELANAYE, Pierre ULg; Liabeuf, Sophie; BOUQUEGNEAU, Antoine ULg et al

in Néphrologie & Thérapeutique (in press)

La matrix-gla-protéine (MGP) est principalement sécrétée par les chondrocytes et les cellules musculaires lisses des parois vasculaires. Son rôle est d’inhiber localement le développement des ... [more ▼]

La matrix-gla-protéine (MGP) est principalement sécrétée par les chondrocytes et les cellules musculaires lisses des parois vasculaires. Son rôle est d’inhiber localement le développement des calcifications vasculaires. MGP doit bénéficier de deux processus post-transcriptionnels avant d’être pleinement active : une phosphorylation de résidus sérine et une carboxylation de résidus glutamate. Cette carboxylation ne peut se faire qu’en présence de quantité suffisante de vitamine K. Plusieurs formes de MGP circulent donc dans le plasma, certaines étant totalement inactives (la MGP déphosphorylée et décarboxylée), d’autres possédant une activité biologique variable en fonction du nombre de sites carboxylés ou phosphorylés. Il existe un lien théorique étroit entre MGP, vitamine K, calcifications vasculaires et maladies cardiovasculaires et ce, particulièrement chez les patients souffrant d’insuffisance rénale chronique, a fortiori s’ils sont dialysés. Si l’existence de ce lien a été démontrée via de nombreuses et solides données fondamentales, les données cliniques restent, à ce jour, observationnelles et doivent donc être interprétées avec prudence. Mesurer une fraction de MGP dans le plasma pour estimer le degré de calcification d’un patient donné n’est pas encore d’actualité . La forme inactive pourrait être utile pour juger des réserves en vitamine K au niveau vasculaire. Dans cet article de revue, nous reviendrons sur les bases théoriques du rôle de MGP dans le processus de calcification vasculaire, sur le défi analytique que représente sa détermination dans le plasma, ainsi que sur les liens entre MGP, vitamine K et calcifications vasculaires en population géne´ rale et chez les patients insuffisants rénaux. [less ▲]

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See detailL’utilisation du facteur de Bayes pour identifier les étudiants qui répondent au hasard
Béland, Sébastien; Raîche, Gilles; Magis, David ULg

in Revue des Sciences de l'Education (in press)

Les méthodes permettant de détecter les réponses au hasard dans l’évaluation des apprentissages présentent quelques limites. Par exemple, les indices de détection de patrons de réponses inappropriés ... [more ▼]

Les méthodes permettant de détecter les réponses au hasard dans l’évaluation des apprentissages présentent quelques limites. Par exemple, les indices de détection de patrons de réponses inappropriés (person-fit indexes) nécessitent généralement de grandes bases de données et permettent seulement de dire si un étudiant répond en accord ou non avec un modèle de mesure (par exemple, le modèle de Rasch). Dans le cadre de cet article, nous présentons une nouvelle approche permettant d’identifier les étudiants qui répondent au hasard lors d'épreuves d'évaluation des apprentissages. Après avoir discuté des limites des principales approches existantes, nous exposons les détails techniques de l'utilisation du facteur de Bayes pour évaluer un nombre fini d'hypothèses informatives. Ensuite, nous appliquons le facteur de Bayes à des données simulées et des données réelles obtenues à des fins d’illustration. Les résultats permettent de voir que le facteur de Bayes est une méthode prometteuse pour détecter le comportement de réponse au hasard. [less ▲]

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See detailPhenotypic variability in bioprocessing conditions can be tracked on the basis of on-line flow cytometry and fits to a scaling law
Baert, Jonathan ULg; Kinet, Romain ULg; Brognaux, Alison ULg et al

in Biotechnology Journal (in press)

Noise in gene and protein expression is a major cause for bioprocess deviation. However, this phenomenon has been only scarcely considered in real bioprocessing conditions. In this work, a scaling-law ... [more ▼]

Noise in gene and protein expression is a major cause for bioprocess deviation. However, this phenomenon has been only scarcely considered in real bioprocessing conditions. In this work, a scaling-law derived from a genome-scale studies based on GFP reporter systems has been calibrated to an on-line flow cytometry device, allowing thus to get an insight at the level of promoter activity and associated noise during a whole microbial culture carried out in bioreactor. We show that most of the GFP reporter systems investigated and thus corresponding genes could be included inside the area covered by the scaling-law. The experimental results suggest that this scaling-law could be used to predict the dynamics of promoter activity, as well as the associated noise, in bioprocessing conditions. The knowledge acquired throughout this work could be used for the design of more robust expression systems. [less ▲]

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See detailRecurrent pulsations in Saturn’s high latitude magnetosphere
Mitchell, D.G.; Carbary, J.F.; Bunce, E.J. et al

in Icarus (in press)

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See detailLa flexicurité revisitée : analyse qualitative interdisciplinaire du discours de travailleurs à l'aide d'un logiciel collaboratif »
Beuker, Laura ULg; DE CIA, Julie ULg; Dervaux, Amélie ULg et al

in Recherches Qualitatives (in press)

L’ambition de cet article est double : explorer les vertus de l’utilisation d’un logiciel d’analyse qualitative dans le cadre d’un travail interdisciplinaire sur la flexicurité, et réaliser une revue de ... [more ▼]

L’ambition de cet article est double : explorer les vertus de l’utilisation d’un logiciel d’analyse qualitative dans le cadre d’un travail interdisciplinaire sur la flexicurité, et réaliser une revue de littérature transversale à partir des problématiques concrètes que ce concept cristallise dans le vécu des travailleurs. La flexicurité constitue un oxymore qui prône la recherche d’un équilibre entre besoins de flexibilité et de sécurité sur le marché du travail. Cet équilibre est avant tout un objectif politique, mais il reste fragile aux yeux des acteurs concernés. En cherchant à croiser le regard analytique de trois disciplines – psychologie, gestion et sociologie –, nous avons recouru au logiciel Cassandre (Lejeune, 2008) pour dégager des tensions discursives autour des notions de flexibilité et de sécurité dans un corpus de vingt entretiens qualitatifs. L’article permet ainsi de concrétiser l’intérêt et les limites de l’utilisation d’un logiciel d’analyse qualitative dans le cadre d’un travail interdisciplinaire. [less ▲]

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See detailCombined use of Ion Mobility and Collision-Induced Dissociation to investigate the opening of disulfide bridges by Electron-Transfer Dissociation in peptides bearing two disulfide bonds
Massonnet, Philippe ULg; Upert, Gregory; Smargiasso, Nicolas ULg et al

in Analytical Chemistry (in press)

Disulfide bonds are post-translational modifications (PTMs) often found in peptides and proteins. They increase their stability towards enzymatic degradations, and provide the structure and (consequently ... [more ▼]

Disulfide bonds are post-translational modifications (PTMs) often found in peptides and proteins. They increase their stability towards enzymatic degradations, and provide the structure and (consequently) the activity of such folded proteins. The characterization of disulfide patterns, i.e the cysteine connectivity, is crucial to achieve a global picture of the active conformation of the protein of interest. Electron Transfer Dissociation (ETD) constitutes a valuable tool to cleave the disulfide bonds in the gas phase, avoiding chemical reduction/alkylation in solution. To characterize the cysteine pairing, the present work proposes (i) to reduce by ETD one of the two disulfide bridges of model peptides , resulting in the opening of the cyclic structures, (ii) to separate the generated species by ion-mobility and, (iii) to characterize the species using CID. Results of this strategy applied to several peptides show different behaviors depending on the connectivity. The loss of SH• radical species, observed for all the peptides, confirms the cleavage of the disulfides during the ETD process. [less ▲]

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See detailHigh concentrations of Myeloperoxidase in the equine uterus as an indicator of endometritis
Parrilla Hernandez, Sonia ULg; Ponthier, Jérôme ULg; Franck, Thierry ULg et al

in Theriogenology (in press)

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears ... [more ▼]

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears. Studies show a relation between neutrophils and myeloperoxidase (MPO), an enzyme contained in and released by neutrophils during degranulation or after cell lysis. This enzyme has been found in many fluids and tissues and associated with different inflammatory pathologies in the horse. The aims of this study were to assess the presence and concentration of MPO in the equine uterus, and to investigate its relation with neutrophils, and other clinical signs of endometritis. Mares (n=51) were evaluated for presence of intra-luminal fluid and excessive endometrial edema before breeding, and a small volume lavage and cytology samples were obtained. From 69 cycles, supernatant of the uterine flushes was analysed with a specific equine MPO ELISA assay to measure MPO concentration. Cytology samples were used for the diagnosis of endometritis. MPO was present in the uterus of all estrus mares in highly variable concentrations. MPO concentrations were significantly (p<0.05) higher in samples with positive cytologies and in presence of intra-luminal fluid. Occasionally, some samples with negative cytologies showed high MPO concentration, but the opposite was never observed. Cycles presenting hyper-edema weren’t associated to high concentration of MPO, intra-luminal fluid or positive cytology making it a poor diagnostic tool of endometritis. [less ▲]

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See detailLes défis colossaux auxquels la santé publique va devoir faire face !
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (in press)

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See detailHuman Papillomavirus-related tumours of the oropharynx display a lower tumour hypoxia signature
Hanns, Elodie; Job, Sylvie; Coliat, Pierre et al

in Oral Oncology (in press)

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See detailLa pollution lumineuse, entre écologie et santé
JEDIDI, Haroun ULg; DEPIERREUX, Frédérique ULg; JEDIDI, Zayd ULg et al

in Revue Médicale de Liège (in press)

Light pollution is defined as the abnormal and disturbing presence of light and its adverse consequences on flora, faunae, ecosystems and its suspected or proven effects on human health. Light pollution ... [more ▼]

Light pollution is defined as the abnormal and disturbing presence of light and its adverse consequences on flora, faunae, ecosystems and its suspected or proven effects on human health. Light pollution is a quite recent and increasing phenomenon within our society and it leads to a major environmental damage, obviously near wildlife, but also on human health (cancers, obesity, fatigue, depression...). The solutions to this problem are however simple, efficient and de facto inexpensive and involving a substantial energy saving. [less ▲]

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See detailImaginer-lire le Capital
Pieron, Julien ULg

in Cahiers d'Etudes Germaniques (in press)

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See detailSiting Controversies Analysis: Framework and Method for Questioning the Procedure
Rossignol, Nicolas ULg; Parotte, Céline ULg; Joris, Geoffrey ULg et al

in Journal of Risk Research (in press)

Siting controversies are commonplace, as well against the construction of roads, railways, nuclear waste disposals, as against windfarms. Local citizens resist against siting decisions taken by the ... [more ▼]

Siting controversies are commonplace, as well against the construction of roads, railways, nuclear waste disposals, as against windfarms. Local citizens resist against siting decisions taken by the authorities, following a dynamics often quoted as ‘Not In My Back Yard’. Yet contested for its lack of analytical value, NIMBY is still used strategically by actors to qualify citizens as irrational and egoistic. Beyond this labelling, many factors are investigated to understand the dynamics behind siting controversies. In this paper, we focus on the impact of the legal procedure structuring the implantation of windfarms in the Walloon Region (Belgium), and its translations within different decision making processes in specific case studies. To that regard, we consider the legal procedure as a ‘public policy instrument’. It is neither neutral nor natural, and carry values and interests. It organizes inter-personal relations between actors, and is potentially catalyzer of frustrations. In addition, this legal procedure is the object of translations within different contexts, including different actors participating to specific decision making processes. The empirical approach of this paper is based on case studies data and on the use of an innovative methodology called ‘Open Process Workshop’. This methodology consists in a structured workshop with key stakeholders, during which the legal procedure is questioned. Overall, we demonstrate that the focus on the legal procedure - and its translations within different decision making processes - allows systemic analysis providing deep understandings of controversies and reaffirming the interlinks between ‘the social’ and ‘the technical’ in such controversies. In addition, we argue that the methodology used fosters the production of innovative knowledge, mutual understanding and collective learning between the participants. [less ▲]

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See detailUncertainty in training image-based inversion of hydraulic head data constrained to ERT data: workflow and case study
Hermans, Thomas ULg; Nguyen, Frédéric ULg; Caers, Jef

in Water Resources Research (in press)

In inverse problems, investigating uncertainty in the posterior distribution of model parameters is as important as matching data. In recent years, most efforts have focused on techniques to sample the ... [more ▼]

In inverse problems, investigating uncertainty in the posterior distribution of model parameters is as important as matching data. In recent years, most efforts have focused on techniques to sample the posterior distribution with reasonable computational costs. Within a Bayesian context, this posterior depends on the prior distribution. However, most of the studies ignore modeling the prior with realistic geological uncertainty. In this paper, we propose a workflow inspired by a Popper-Bayes philosophy, that data should first be used to falsify models, then only be considered for matching. We propose a workflow consisting of three steps: (1) in defining the prior, we interpret multiple alternative geological scenarios from literature (architecture of facies) and site specific data (proportions of facies). Prior spatial uncertainty is modeled using multiple-point geostatistics, where each scenario is defined using a training image. (2) We validate these prior geological scenarios by simulating electrical resistivity tomography (ERT) data on realizations of each scenario and comparing them to field ERT in a lower dimensional space. In this second step, the idea is to probabilistically falsify scenarios with ERT, meaning that scenarios which are incompatible receive an updated probability of zero while compatible scenarios receive a non-zero updated belief. (3) We constrain the hydrogeological model with hydraulic head and ERT using a stochastic search method. The workflow is applied to a synthetic and a field case studies in an alluvial aquifer. This study highlights the importance of considering and estimate prior uncertainty (without data) through a process of probabilistic falsification. [less ▲]

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See detailLeidenfrost drops: effect of gravity
Maquet, Laurent ULg; Brandenbourger, Martin ULg; Sobac, Benjamin et al

in Europhysics Letters [=EPL] (in press)

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See detailDevelopment by the sol–gel process of highly dispersed Ni–Cu/SiO2 xerogel catalysts for selective 1,2-dichloroethane hydrodechlorination into ethylene
Pirard, Sophie ULg; Mahy, Julien ULg; Pirard, Jean-Paul ULg et al

in Microporous and Mesoporous Materials (in press)

Ni–Cu/SiO2 xerogel catalysts have been synthesized by cogelation of industrial tetraethoxysilane (Dynasil) and chelates of Ni and Cu with industrial 3-(2-aminoethylamino)propyltrimethoxysilane (Dynasylan ... [more ▼]

Ni–Cu/SiO2 xerogel catalysts have been synthesized by cogelation of industrial tetraethoxysilane (Dynasil) and chelates of Ni and Cu with industrial 3-(2-aminoethylamino)propyltrimethoxysilane (Dynasylan DAMO) in industrial ethanol denatured with diethyl phthalate. Despite the use of industrial grade reagents, highly dispersed bimetallic Ni–Cu/SiO2 xerogel catalysts were obtained. These samples are composed of completely accessible Ni–Cu alloy crystallites with sizes of 1.6–3.4 nm located inside silica particles exhibiting a monodisperse microporous distribution. It appears that the bimetallic complex acts as a nucleation agent in the formation of silica particles. The combination of results obtained from the calculation of the metal ratio in catalysts, H2 chemisorption and transmission electron microscopy allowed calculating the surface composition of the nickel–copper particles in Ni–Cu/SiO2 cogelled xerogel catalysts. Values obtained indicate a very pronounced surface enrichment with copper. While 1,2-dichloroethane hydrodechlorination over pure nickel mainly produces ethane, increasing copper content in bimetallic catalysts results in an increase in ethylene selectivity. The specific consumption rate of 1,2-dichloroethane decreases when copper loading increases. The turnover frequency, that is, the number of catalytic cycle per active site (nickel atom and its surrounding copper atoms) and per second, seems to be independent of surface composition of alloy particles. [less ▲]

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See detailEvidence of contrasting patterns for suppression and reappraisal emotional regulation strategies in alexithymia.
Laloyaux, Julien ULg; Fantini, Carole; Lemaire, Morgan ULg et al

in Journal of Nervous & Mental Disease (in press)

Alexithymia generally refers to difficulties in identifying and describing emotions. In this paper, two studies explored whether the emotional deficits observed in alexithymia may be related to the use of ... [more ▼]

Alexithymia generally refers to difficulties in identifying and describing emotions. In this paper, two studies explored whether the emotional deficits observed in alexithymia may be related to the use of emotional regulation strategies. Relations with various socio-demographic variables were also explored. In the first study, 255 students completed the Emotion Regulation Questionnaire (ERQ) and the Toronto Alexithymia Scale-20. For the second study, 1107 participants from the general population completed the ERQ and the Bermond-Vorst Alexithymia Questionnaire. Results demonstrated that alexithymia was related to the use of a suppression strategy and in particular to difficulties verbalizing emotions, suggesting that the capacity to communicate and name one’s emotion is a central aspect in alexithymia. Concerning socio-demographic variables, alexithymia and the use of a suppression strategy were found to be related to age and to be higher in males. The results of these studies and their clinical implications for treatment are discussed. [less ▲]

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailThe importance of the tumor microenvironment in the therapeutic management of cancer
Pottier, Charles ULg; Wheatherspoon, Alodie; RONCARATI, Patrick ULg et al

in Expert Review of Anticancer Therapy (in press)

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See detailSociologie de la communication politique
Devresse, Jenifer ULg

in Communication (in press)

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See detailGenotype contribution to the chemical composition of banana rachis and implications for thermo/biochemical conversion
Tiappi Deumaga, Mathias Florian; Happi Emaga, Thomas; Tchokouassom, Raphael et al

in Biomass Conversion and Biorefinery (in press)

Chemical composition of banana rachis from three varieties (Grande naine, Pelipita, and CRBP969) was ana- lyzed, and the genotype contribution to composition variabil- ity was investigated. Wet chemistry ... [more ▼]

Chemical composition of banana rachis from three varieties (Grande naine, Pelipita, and CRBP969) was ana- lyzed, and the genotype contribution to composition variabil- ity was investigated. Wet chemistry and instrumental analysis procedures (X-ray diffraction, 31P NMR spectroscopy, and thermogravimetry) were used. Some significant differences were found among the three genotypes: GN-AAA genotype was found to be significantly the highest in ash fraction (30.16 %) and the lowest in acid insoluble lignin (6.58 %) at 95 % confidence level. It showed also the highest content in potassium (43.5 % in ash). Implication of compositional dif- ferences on valorization efficiency by biochemical or thermo- chemical pathways was investigated. For this purpose, corre- lation coefficients between compositional characteristics and yields in volatile compounds from pyrolysis and glucose yields from enzymatic saccharification were analyzed. Ash content was revealed to be the main drawback parameter for volatile yields from pyrolysis (r = −0.93), while for glucose yields during saccharification were limited mainly by the con- tent in guaiacyl units of the lignin fraction (r = −0.98). How- ever, a strong and positive correlation was established be- tween the volatiles yield and the acid insoluble lignin content (r = 0.98) Thus, according to these observations and based on their compositional significant differences, GN-AAA was the better candidate for bioconversion pathway while PPT-ABB and CRBP969-AAAB samples were shown to be better can- didates for thermochemical conversion pathway. This work gives important preliminary information for considering ba- nana rachis as an interesting feedstock candidate for biorefinery. [less ▲]

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See detailBiochemical characterization of the oil of durum wheat germ (Tunisian variety)
Kammoun, Maroua; Rassâa, Neila; Mejri-Gaïda, Myriam et al

in Journal of New Sciences (in press)

The wheat germ oil may constitute an alternative to the misuse of this cereal grain resource. The Tunisian exploitation is limited, at present, in the human and animal feed in the grain form, straw or ... [more ▼]

The wheat germ oil may constitute an alternative to the misuse of this cereal grain resource. The Tunisian exploitation is limited, at present, in the human and animal feed in the grain form, straw or some transformed products. For the purpose of characterization, the wheat germ oil has been extracted by Soxhlet apparatus from a Tunisian variety of durum wheat (Maali) based on the hexane as a solvent. An analysis by gas chromatography (GC) was then performed to identify and quantify the fatty acids of the oil. Then, the oil has submitted to a second chromatography analysis in liquid phase (HPLC) to quantify the tocopherols. The most important fatty acids constituting have been the two polyunsaturated acids linoleic acid C18:2 (OMEGA 6) and the gamma acid- linoleic C18:3 : 58.24 % and 4.19 % respectively; and the acid monounsaturated oleic acid C18:1 ( 24.49 %) but also some saturated acid: palmitic acid C16:0 with ( 19.50 % ), and the stearic acid C18:0 (1.29%). For this variety of Tunisian durum wheat, the wheat germ oil contains, in addition, 80.27 mg / 100g of α- tocopherols (vitamin E). The wheat germ oil extracted from the Tunisian variety 'Maali' has proved rich in vitamin E and omega-6 ; a better valorisation on the nutritional or pharmaceutical plan is to this title recommended. [less ▲]

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See detailClinical sentinel surveillance of equine West Nile fever, Spain
Saegerman, Claude ULg; Alba-Casals, A; Garcia-Bocanegra, I et al

in Transboundary and Emerging Diseases (in press)

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See detailModulation of ciliary phosphoinositide content regulates trafficking and Sonic hedgehog signaling output
Chavez, M; Van Sande, J; de Kerchove d'Exaerde, A et al

in Developmental Cell (in press)

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See detailHigh Resolution postontrast time of flight MR angiography of intracranial perforators at 7.0 Tesla
Harteveld, A; de Cocker, L; Dieleman, N et al

in American Journal of Neuroradiology (in press)

Detailed reference viewed: 9 (0 ULg)