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See detailGenetic diversity, Population structure, parentage analysis, and construction of core collections in the French apple germplasm based on SSR markers
Lassois, Ludivine ULg; Denancé, Caroline; Ravon, Elisa et al

in Plant Molecular Biology Reporter (2016), 34(4), 827-844

In-depth characterization of apple genetic resources is a prerequisite for genetic improvement and for germplasm management. In this study, we fingerprinted a very large French collection of 2163 ... [more ▼]

In-depth characterization of apple genetic resources is a prerequisite for genetic improvement and for germplasm management. In this study, we fingerprinted a very large French collection of 2163 accessions with 24 SSR markers in order to evaluate its genetic diversity, population structure and genetic relationships, to link these features with cultivar selection date or usage (old or modern, dessert or cider cultivars), and to construct core collections. Most markers were highly discriminating and powerful for varietal identification, with a probability of identity P(ID) over the 21 retained SSR loci close to 10-28. Pairwise comparisons revealed 34% redundancy and 18.5% putative triploids. The results showed that the germplasm is highly diverse with an expected heterozygosity He of 0.82 and observed heterozygosity Ho of 0.83. A Bayesian model-based clustering approach revealed a weak but significant structure in three subgroups (FST = 0.014-0.048) corresponding, albeit approximately, to the three subpopulations defined beforehand (Old Dessert, Old Cider and Moderncultivars). Parentage analyses established already known and yet unknown relationships, notably between old cultivars, with the frequent occurrence of cultivars such as ‘King of Pippin’ and ‘Calville Rouge d’Hiver’ as founders. Finally, core collections based on allelic diversity were constructed. A large dessert core collection of 278 cultivars contained 90% of the total dessert allelic diversity, whereas a dessert sub-core collection of 48 cultivars contained 71% of diversity. For cider apples, a 48-cultivars core collection contained 83% of the total cider allelic diversity. [less ▲]

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See detailToward “Concessions 2.0”: articulating inclusive and exclusive management in production forests in Central Africa
Karsenty, Alain; Vermeulen, Cédric ULg

in International Forestry Review (2016), 18(S1), 13

Industrial forest concessions cover about 45 million hectares in Central Africa. This paper discusses the weaknesses of the current concession model and initiatives for helping it evolve; it then proposes ... [more ▼]

Industrial forest concessions cover about 45 million hectares in Central Africa. This paper discusses the weaknesses of the current concession model and initiatives for helping it evolve; it then proposes a new type of concession, entitled ‘Concessions 2.0’, adapted to the future challenges presented by the overlapping among the rights and modes of the harvesting of multiple resources. This proposed model is based on four features: (i) mapping and recognition of the customary territories within and around the industrial concession, (ii) timber revenue sharing indexed on the extension of the customary territories and contractual management agreements within the communities, (iii) allowance of commercial exploitation of non-timber resources by entitled claimers under the supervision and/or in association with the concessionaire, and (iv) inclusive governance for the management of overlapping rights over the concession area. [less ▲]

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See detailLinseed oil presents different patterns of oxidation in real-time and accelerated aging assays
Douny, Caroline ULg; Razanakolona, Rina; Ribonnet, Laurence et al

in Food Chemistry (2016), 208

This study aimed at verifying if the hypothesis that one day at 60 °C is equivalent to one month at 20 °C could be confirmed during linseed oil aging for 6 months at 20 °C and 6 days at 60 °C using the ... [more ▼]

This study aimed at verifying if the hypothesis that one day at 60 °C is equivalent to one month at 20 °C could be confirmed during linseed oil aging for 6 months at 20 °C and 6 days at 60 °C using the “Schaal oven stability test”. Tests were conducted with linseed oil supplemented or not with myricetin or butyl-hydroxytoluene as antioxidants. Oxidation was evaluated with the peroxide and p-anisidine values, as well as the content in conjugated dienes and aldehydes. All four indicators of oxidation showed very different kinetic behaviors at 20 and 60 °C. The hypothesis is thus not verified for linseed oil, supplemented or not with antioxidant. In the control oil, the conjugated dienes and the peroxide value observed were respectively of 41.8 ± 0.8 Absorbance Unit (AU)/g oil and 254.3 ± 5.8 meq. O2/kg oil after 6 months at 20 °C. These values were of 18.2 ± 1.3 AU/g oil and 65.2 ± 20.3 meq. O2/kg after 6 days at 60 °C. [less ▲]

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See detailThe spatiality of local governments in European intermediate urban regions: a methodological approach
Breuer, Christophe ULg; Halleux, Jean-Marie ULg

in Quaestiones Geographicae (2016)

Local authorities are central actors in the governance of European intermediate urban regions. In this paper, we propose a methodology to analyse the fragmentation of local authorities within 119 urban ... [more ▼]

Local authorities are central actors in the governance of European intermediate urban regions. In this paper, we propose a methodology to analyse the fragmentation of local authorities within 119 urban regions. We tested several European databases to create indicators of fragmentation and to develop a typology of fragmentation within cities. Our results show that the Eurostat Cities programme gives a consistent spatial definition of urban regions and that their fragmentation is mainly influenced by national contexts. The developed methodology is a contribution to the debate on territorial reforms and urban governance transformations. [less ▲]

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See detailAirewater interfacial properties of enzymatic wheat gluten hydrolyzates determine their foaming behavior
Wouters, Arno G.B.; Rombouts, Ine; Legein, Marie et al

in Food Hydrocolloids (2016), 55

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different ... [more ▼]

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different peptic and tryptic wheat gluten hydrolyzates were related to the kinetics of their adsorption at an airewater interface as well as to the properties of a compressed protein film at this interface. Foams from degree of hydrolysis (DH, i.e. the percentage of cleaved peptide bonds) 2 hydrolyzates were more stable than those from their DH 6 counterparts, and this at all protein concentrations tested. However, at protein concentrations from 0.010% to 0.050% (wprot/v), peptic DH 2 and 6 hydrolyzates had better foaming stability than their tryptic counterparts of the same DH. The opposite was observed when protein concentrations ranged from 0.050% to 0.150% (wprot/v). These observations can in part be explained by the molecular mass composition of the samples and, more importantly, by high levels of hydrophobic peptides in the DH 2 samples. The calculation of an average elasticity (up to 20e25 mN/m) from the variation in surface pressure for a variation in surface area in Langmuir isotherms showed that DH 2 samples had higher elasticity than DH 6 samples, which was in agreement with their foaming stabilities at various protein concentrations. Additionally, although not usually considered in literature, it seemed there was a correspondence between surface pressure at different protein surface concentrations and foaming stability at different protein concentrations. [less ▲]

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See detailChemical constituents from Erythrina droogmansiana (Fabaceae), radical scavenging and antibacterial potential of some extracts and compounds
Talla, Emmanuel; Yaya Gbaweng, Joël; Mokale, Laurel et al

in Natural Products : An Indian Journal (2016), 12(1), 12-20

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2 ... [more ▼]

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2), erythrinasinate A (3), erythrinasinate B (4), abyssinone-IV-4'-methylether (5), erythrabyssin (6), phaseollidin (7), 4’-methoxylicoflavanone (8) and abyssinone-V-4'-methylether (9) respectively from methanolic extract of roots wood and EtOAc extract of roots bark of the same plant. Their structures were elucidated using spectroscopic methods (MS, NMR and IR) and by comparison with some data found in literature. Free radical scavenging (DPPH) and antibacterial potentials of extracts and compounds were also evaluated in this work. For radical scavenging, results showed that it is phaseollidin (7) which is responsible of radical scavenging potential in the ethyl acetate extract of roots barks with value of 1.31 mg/ml; for antibacterial, one of the tested compounds abyssinone-IV-4'-methylether (5) exhibited antibacterial activities against two strains: Providencia stuartiiATCC 29916 and Enterobacter aerogenes ATCC 13048 with MIC values of 25μg/ml. [less ▲]

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See detailNa2FePO4F/multi-walled carbon nanotubes for lithium-ion batteries: Operando Mössbauer study of spray-dried composites
Brisbois, Magali; Caes, Sébastien ULg; Sougrati, M.T. et al

in Solar Energy Materials & Solar Cells (2016), 148

In order to favor electronic conductivity in sodium iron fluorophosphate electrodes for lithium- or sodium-ion batteries, composites of Na2FePO4F with multi-walled carbon nanotubes (CNTs) were prepared by ... [more ▼]

In order to favor electronic conductivity in sodium iron fluorophosphate electrodes for lithium- or sodium-ion batteries, composites of Na2FePO4F with multi-walled carbon nanotubes (CNTs) were prepared by pilot-scale spray drying. Addition of multi-walled CNTs in the solution results in an excellent dispersion of the CNTs within the volume of Na2FePO4F and not only at the surface of the particles. Following a heat treatment at 600°C in argon in order to reach crystallization, X-ray diffraction and ex situ Mössbauer spectroscopy revealed the presence of significant amounts of Fe(III) and maghemite (γ-Fe2O3) in the powder. However, Na2FePO4F/CNTs composites exhibit good electrochemical performance when cycling against lithium, with a discharge capacity of 104mAhg-1 at C/10 rate and 90mAhg-1 at 1C rate. Therefore, operando 57Fe transmission Mössbauer spectroscopy analyses were carried out in order to investigate the evolution of the iron oxidation state during cycling. During the first discharge, all the Fe(III) is reduced to Fe(II), explaining the good electrochemical performance. [less ▲]

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See detailA pilot double-blind, randomized, placebo-controlled trial of the efficacy of trace elements in the treatment of endometriosis-related pain: study design and methodology
OBERWEIS, Didier; MANDELENAT, Patrick; Nisolle, Michelle ULg

in Nutrition and Dietary Supplements (2016), 8

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various ... [more ▼]

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various distressing symptoms, particularly pelvic pain, which adversely affect patients’ quality of life. It is an estrogen-dependent disease. There is evidence both in animals and in humans that metal ions can activate the estrogen receptors. They are defined as a variety of xenoestrogens, called metalloestrogens, which could act as endocrine disruptors. Therefore, it could be considered to act on this gynecological disorder using food supplements containing trace elements (ie, nutripuncture). The assumption is that they could modulate estrogen receptors and thus influence the tropism and the survival of cells involved in endometriosis. By a modulation of the antioxidant system, they might also interact with various parameters influencing tissue biochemistry. The objective of this article is to describe and discuss the design and methodology of an ongoing double-blind, randomized, placebo-controlled study aiming to evaluate the efficacy of metal trace elements on the reduction of pain and improvement of quality of life, in patients with a revised American Fertility Society Score Stages II–IV endometriosis, combined or not with adenomyosis, during a treatment period of 4 months. Trace elements or placebo is proposed in the absence of any other treatment or as an add-on to current therapies, such as sexual hormones, nonsteroidal anti-inflammatory drugs, and surgery. A placebo run-in period of one menstrual cycle or 30 days for women in amenorrhea has been scheduled to eliminate the patients who are responding too much to the placebo. After a 1:1 ratio randomization on Day 0, the treatment with trace elements or placebo will last for 4 monts (120 days). [less ▲]

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See detailThe combined mechanism of bone morphogenetic protein- and calcium phosphate-induced skeletal tissue formation by human periosteum derived cells.
Bolander, J.; Ji, W.; Geris, Liesbet ULg et al

in European Cells and Materials (2016), 31

When combining osteogenic progenitor cells such as human periosteum derived cells (hPDCs) with osteoconductive biomaterials like calcium phosphate (CaP)-scaffolds, in vivo bone formation can be achieved ... [more ▼]

When combining osteogenic progenitor cells such as human periosteum derived cells (hPDCs) with osteoconductive biomaterials like calcium phosphate (CaP)-scaffolds, in vivo bone formation can be achieved. This process is dependent on the early activation of Bone morphogenetic protein (BMP)-signalling. However, the bone forming process is slow and routinely only a limited amount of bone and bone marrow is formed. Therefore, we hypothesised that a robust clinically relevant outcome could be achieved by adding more physiological levels of potent BMP-ligands to these cell- and CaP-based constructs. For this, hPDCs were characterised for their responsiveness to BMP-ligands upon in vitro 2D stimulation. BMP-2, -4, -6 and -9 robustly induced osteochondrogenic differentiation. Subsequently, these ligands were coated onto clinically approved CaP-scaffolds, BioOss(R) and CopiOs(R), followed by hPDC-seeding. Protein lysates and conditioned media were investigated for activation of BMP signalling pathways. Upon in vivo implantation, the most abundant bone formation was found in BMP-2 and BMP-6-coated scaffolds. Implanted cells actively contributed to the newly formed bone. Remnants of cartilage could be observed in BMP-coated CopiOs(R)-constructs. Computational analysis displayed that the type of BMP-ligand as well as the CaP-scaffold affects skeletal tissue formation, observed in a qualitative as well as quantitative manner. Furthermore, the in vitro mechanism appears to predict the in vivo outcome. This study presents further evidence for the potential of BMP-technology in the development of clinically relevant cell-based constructs for bone regenerative strategies. [less ▲]

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See detailOrigin of dc voltage in type II superconducting flux pumps: field, field rate of change, and current density dependence of resistivity
Geng, J.; Matsuda, K.; Fu, L. et al

in Journal of Physics : D Applied Physics (2016), 49(11), 1101

Superconducting flux pumps are the kind of devices which can generate direct current into superconducting circuit using external magnetic field. The key point is how to induce a dc voltage across the ... [more ▼]

Superconducting flux pumps are the kind of devices which can generate direct current into superconducting circuit using external magnetic field. The key point is how to induce a dc voltage across the superconducting load by ac fields. Giaever (1966 IEEE Spectr . 3 [http://dx.doi.org/10.1109/MSPEC.1966.5217702] 117 ) pointed out flux motion in superconductors will induce a dc voltage, and demonstrated a rectifier model which depended on breaking superconductivity. van de Klundert et al (1981 Cryogenics 21 [http://dx.doi.org/10.1016/0011-2275(81)90195-8] 195, 267 ) in their review(s) described various configurations for flux pumps all of which relied on inducing the normal state in at least part of the superconductor. In this letter, following their work, we reveal that a variation in the resistivity of type II superconductors is sufficient to induce a dc voltage in flux pumps and it is not necessary to break superconductivity. This variation in resistivity is due to the fact that flux flow is influenced by current density, field intensity, and field rate of change. We propose a general circuit analogy for travelling wave flux pumps, and provide a mathematical analysis to explain the dc voltage. Several existing superconducting flux pumps which rely on the use of a travelling magnetic wave can be explained using the analysis enclosed. This work can also throw light on the design and optimization of flux pumps. [less ▲]

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See detailDSIMA: A testbed for the quantitative analysis of interaction models within distribution networks
Mathieu, Sébastien ULg; Louveaux, Quentin ULg; Ernst, Damien ULg et al

in Sustainable Energy, Grids and Networks (2016), 5

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in ... [more ▼]

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in which the distribution system operator, the transmission system operator, producers and retailers make their decisions based on mixed-integer linear programs. This testbed helps to highlight the characteristics of an interaction model, the benefits for the agents and eases the detection of unwanted or abusive behaviors which decreases the welfare. The testbed is implemented in Python and the optimization problems are encoded in the modeling language ZIMPL. A web interface is coupled with an instance generator using macroscopic parameters of the system such as the total power production. This testbed is, therefore, well suited to test the implemented interaction models on various scenarios and to extend the implementation to other models. Five interaction models developed with industrial partners are simulated over a year on a 75-bus test system. Simulations show that interaction models relying on active network management, as they have been developed, lead to substantial welfare even though they suffer from a lack of coordination between the DSO and the TSO. A conservative interaction model restricting grid users to an access range that is computed ahead of time to prevent any congestion, avoids shedding distributed generation but considerably restrains the amount of distributed production. [less ▲]

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See detailPositive Operations on Wastewater Sludge Drying: Comparison of Back-Mixing and Sawdust Addition
Li, Jie; Plougonven, Erwan ULg; Fraikin, Laurent ULg et al

in Energy & Fuels (2016), 30(4), 3014-3019

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See detailPhysical, functional and structural characterization of the cell wall fractions from baker's yeast Saccharomyces cerevisiae
Borchani, C.; Fonteyn, F.; Jamin, G. et al

in Food Chemistry (2016), 194

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast ... [more ▼]

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast cell wall fractionation process involving enzymatic treatments (savinase and lipolase enzymes) affected most of the physical and functional characteristics of extracted fractions. Thus, the fractionation process showed that β-D-glucan fraction F4 had significantly higher swelling power and fat binding capacity compared to other fractions (F1, F2 and F3). It also exhibited a viscosity of 652.12 mPa s and a high degree of brightness of extracted β-D-glucan fraction. Moreover, the fractionation process seemed to have an effect on structural and thermal properties of extracted fractions. Overall, results showed that yeast β-D-glucan had good potential for use as a prebiotic ingredient in food, as well as medicinal and pharmaceutical products. © 2015, Elsevier Ltd. All rights reserved. [less ▲]

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See detailThe effect of pre-industrial charcoal kilns on chemical properties of forest soil of Wallonia, Belgium
Hardy, Brieuc; Cornelis, Jean-Thomas ULg; Houben, David et al

in European Journal of Soil Science (2016)

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See detailPas d'obstacle constitutionnel pour les sanctions administratives communales
Michiels, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), (2016/1), 79-99

Le législateur, lors de l’instauration du système des sanctions administratives communales, a entendu combattre les incivilités. Cette notiond’«incivilité» vise des comportements dans l’espace public qui ... [more ▼]

Le législateur, lors de l’instauration du système des sanctions administratives communales, a entendu combattre les incivilités. Cette notiond’«incivilité» vise des comportements dans l’espace public qui s’écartent de ce qui est convenable dans la vie en société. En veillant à définir les «incivilités» comme les formes les plus légères de trouble de l’ordre public, de la sécurité, de la santé et de la propreté, qui sont dégradants ou incommodants et qui dépassent les contraintes normales de la vie sociale, le législateur a satisfait aux exigences du principe de légalité.Le droit à une bonne administration de la justice tel qu’il est garanti par l’article 6 de la Convention européenne des droits de l’homme, n’exclut pas qu’une sanction administrative soit infligée par un fonctionnaire, à condition qu’un juge indépendant et impartial puisse exercer un contrôle de pleine juridic-tion sur cette décision administrative. [less ▲]

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See detailImprovement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Hamaïdia, Malik ULg; Staumont, Bernard ULg; DUYSINX, Bernard ULg et al

in Current Topics in Medicinal Chemistry (2016), 16

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor ... [more ▼]

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators. [less ▲]

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See detailNewt life after fish introduction: extirpation of paedomorphosis in a mountain fish lake and newt use of satellite pools
Denoël, Mathieu ULg; Scime, Patrick; Zambelli, Nicola

in Current Zoology (2016), 62(1), 61-69

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context ... [more ▼]

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context, we determined whether small wetlands, such as pools surrounding fished and fishless lakes, could sustain paedomorphic and metamorphic newts. To this end, we surveyed lakes known historically to sustain Alpine newts (Ichthyosaura alpestris) as well as 35 nearby pools. On the basis of the published records, the only known population exhibiting paedomorphosis in the Swiss Alps was found to be extirpated by salmonid introductions. However, the metamorphs persisted in peripheral pools, paedomorphosis was discovered at a new locality, and overwintering larvae were still present in one of the lakes. These results show the importance of conserving varied aquatic habitats such as pools in mountainous environments where the main resources can become unsuitable for amphibians because of fish introductions. Pools may also function as reservoirs in maintaining newt populations until programs to remove fish from lakes can be carried out. It is not known if paedomorphs could reappear after fish removal. However, the combined resilience of amphibians after fish removal and the genetic basis for paedomorphosis highlighted in other taxa by previous studies suggest that there is the potential to maintain this intraspecific case of diversity even after its disappearance. [less ▲]

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See detailEfficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Bruyère, Olivier ULg; Altman, R.D.; Reginster, Jean-Yves ULg

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 12-17

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) including glucosamine sulfate (GS) and chondroitin sulfate (CS) as first-line therapy for knee osteoarthritis (OA). Numerous studies are published on the use of SYSADOAs in OA; however, the efficacy of this class is still called into question largely due to the regulatory status, labeling and availability of these medications which differ substantially across the world. Examination of the evidence for the prescription patented crystalline GS (pCGS) formulation at a dose of 1500 mg once-daily demonstrates superiority overother GS and glucosamine hydrochloride (GH) formulations and dosage regimens. Thus, the ESCEO task force advocates differentiation of prescription pCGS over other glucosamine preparations. Long-term clinical trials andreal-life studies show that pCGS may delay joint structural changes, suggesting potential benefit beyond symptom control when used early in the management of knee OA. Real-life pharmacoeconomic studies demonstrate a long-term reduction in the need for additional pain analgesia and non-steroidal anti-inflammatory drugs (NSAIDs) with pCGS, with a significant reduction of over 50% in costs associated with medications, healthcare consultations and examinations over 12 months. Furthermore, treatment with pCGS for at least 12 months leads to a reduction in the need for total joint replacement for at least 5 years following treatment cessation. Thus, pCGS(1500 mg od) is a logical choice to maximize clinical benefit in OA patients, with demonstrated medium-term control of pain and lasting impact on disease progression. [less ▲]

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See detailFluorodeoxyglucose F Positron Emission Tomography Coupled With Computed Tomography in Suspected Acute Renal Allograft Rejection.
Lovinfosse, P.; Weekers, L.; Bonvoisin, C. et al

in American Journal of Transplantation (2016)

Management of kidney transplant recipients (KTRs) with suspected acute rejection (AR) ultimately relies on kidney biopsy; however, noninvasive tests predicting nonrejection would help avoid unnecessary ... [more ▼]

Management of kidney transplant recipients (KTRs) with suspected acute rejection (AR) ultimately relies on kidney biopsy; however, noninvasive tests predicting nonrejection would help avoid unnecessary biopsy. AR involves recruitment of leukocytes avid for fluorodeoxyglucose F18 (18 F-FDG), thus 18 F-FDG positron emission tomography (PET) coupled with computed tomography (CT) may noninvasively distinguish nonrejection from AR. From January 2013 to February 2015, we prospectively performed 32 18 F-FDG PET/CT scans in 31 adult KTRs with suspected AR who underwent transplant biopsy. Biopsies were categorized into four groups: normal (n = 8), borderline (n = 10), AR (n = 8), or other (n = 6, including 3 with polyoma BK nephropathy). Estimated GFR was comparable in all groups. PET/CT was performed 201 +/- 18 minutes after administration of 3.2 +/- 0.2 MBq/kg of 18 F-FDG, before any immunosuppression change. Mean standard uptake values (SUVs) of both upper and lower renal poles were measured. Mean SUVs reached 1.5 +/- 0.2, 1.6 +/- 0.3, 2.9 +/- 0.8, and 2.2 +/- 1.2 for the normal, borderline, AR, and other groups, respectively. One-way analysis of variance demonstrated a significant difference of mean SUVs among groups. A positive correlation between mean SUV and acute composite Banff score was found, with r2 = 0.49. The area under the receiver operating characteristic curve was 0.93, with 100% sensitivity and 50% specificity using a mean SUV threshold of 1.6. In conclusion, 18 F-FDG PET/CT may help noninvasively prevent avoidable transplant biopsies in KTRs with suspected AR. [less ▲]

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See detailExperimental Comparative Study on Lithium Chloride and Calcium Chloride Desiccants
Bouzenada, Saliha ULg; Kaabi, A. N.; Fraikin, Laurent ULg et al

in Procedia Computer Science (2016), 83(718-725),

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See detailConstraints on the structure of 16 Cygni A and 16 Cygni B using inversion techniques
Buldgen, Gaël ULg; Reese, Daniel; Dupret, Marc-Antoine ULg

in Astronomy and Astrophysics (2016)

Abstract Constraining mixing processes and chemical composition is a central problem in stellar physics as their impact on stellar age determinations leads to biases in our studies of stellar evolution ... [more ▼]

Abstract Constraining mixing processes and chemical composition is a central problem in stellar physics as their impact on stellar age determinations leads to biases in our studies of stellar evolution, galactic history and exoplanetary systems. In two previous papers, we showed how seismic inversion techniques could offer strong constraints on such processes by pointing out weaknesses in theoretical models. We now apply our technique to the solar analogues 16CygA and 16CygB, being amongst the best targets in the Kepler field to test the diagnostic potential of seismic inversions. The combination of various seismic indicators helps to provide more constrained and accurate fundamendal parameters for these stars. We use the latest seismic, spectroscopic and interferometric observational constraints in the litterature for this system to determine reference models independently for both stars. We carry out seismic inversions of the acoustic radius, the mean density and a core conditions indicator. We note that a degeneracy exists for the reference models. Namely, changing the diffusion coefficient or the chemical composition within the observational values leads to 5% changes in mass, 3% changes in radius and up to 8% changes in age. We use acoustic radius and mean density inversions to improve our reference models then carry out inversions for a core conditions indicator. Thanks to its sensitivity to microscopic diffusion and chemical composition mismatches, we are able to reduce the mass dispersion to 2%, namely [0.96, 1.0] M_sun, the radius dispersion to 1%, namely [1.188, 1.200] R_sun and the age dispersion to 3%, namely [7.0, 7.4] Gy, for 16CygA. For 16CygB, we can check the consistency of the models but not reduce independently the age dispersion. Nonetheless, assuming consistency with the age of 16CygA helps to further constrain its mass and radius. [less ▲]

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See detailMiddle Miocene climate and vegetation models and their validation with proxy data
Henrot, Alexandra-Jane ULg; Utescher, T.; Erdei, B. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2016)

The Miocene is a relatively recent epoch of the Earth's history with warmer climate than today, particularly during the middle Miocene Climatic Optimum (MMCO, approximately 17-15Ma). Although the cause of ... [more ▼]

The Miocene is a relatively recent epoch of the Earth's history with warmer climate than today, particularly during the middle Miocene Climatic Optimum (MMCO, approximately 17-15Ma). Although the cause of the warming is probably not only attributable to CO2, but also to changes in orography and configuration of ocean gateways, this time interval represents an ideal case study to test the ability of climate models to simulate warm climates comparable to those that the Earth may experience in the near future. However, even with higher than present-day CO2 concentrations, the MMCO warming inferred from terrestrial proxy data has been difficult to reproduce in climate models.Since fossil flora do not provide direct information on climate, but on flora and vegetation, climate model results are generally compared to climate reconstructions obtained from the fossil flora. In this study, we apply an alternative method by simulating palaeovegetation from the outputs of the climate model, using a dynamic vegetation model. Model vegetation reconstruction can then be compared to the vegetation cover indicated by the fossil flora record at the various localities, provided that a common classification of plant functional types (PFTs) is used for the data and the model. Here, we reconstruct the vegetation of the middle Miocene with the global dynamic vegetation model CARAIB, using the climatologies derived from five atmospheric general circulation models. The reliability of the simulations is examined on a presence/absence basis of PFTs by comparison of vegetation reconstructions to palaeoflora data recorded in the Northern Hemisphere and the Tropics.This comparison provides an overall agreement around 60% between model and data, when all sites and tree types are considered. Three model simulations out of five show to be better at predicting the absence than the presence. The presence of warm-temperate mixed forests in the middle latitudes, dominated by broadleaved deciduous warm temperate and subtropical trees is generally well reproduced in CARAIB simulations. However, poor agreement is obtained for the presence of tropical PFTs out of the Tropics and for warm PFTs at latitudes northward of 50°N, where climate models remain too cold to produce assemblages of trees consistent with the data. Nevertheless, the model-data comparison performed here highlights several mismatches that could result not only from missing feedbacks in the climate simulations, but also from the data. The results of the likelihood analysis on presence/absence of PFTs illustrate the uncertainties in the PFT classification of the Neogene floral records. The coexistence of some PFTs in the palaeovegetation data is impossible to reproduce in the vegetation model simulations because of the climatic definition of the modern PFTs. This result indicates either a bias in the identification of modern analogues for fossil plant taxa, or a possible evolution of environmental requirements of certain plants. © 2016 Elsevier B.V. [less ▲]

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See detailTransient performance evaluation of waste heat recovery Rankine cycle based system for heavy duty trucks
Grelet, Vincent; Reiche, Thomas; Lemort, Vincent ULg et al

in Applied Energy (2016)

The study presented in this paper aims to evaluate the transient performance of a waste heat recovery Rankine cycle based system for a heavy duty truck and compare it to steady state evaluation. Assuming ... [more ▼]

The study presented in this paper aims to evaluate the transient performance of a waste heat recovery Rankine cycle based system for a heavy duty truck and compare it to steady state evaluation. Assuming some conditions to hold, simple thermodynamic simulations are carried out for the comparison of several fluids. Then a detailed rst principle based model is also presented. Last part is focused on the Rankine cycle arrangement choice by means of model based evaluation of fuel economy for each concept where the fuels savings are computed using two methodologies. Fluid choice and concept optimization are conducted taking into account integration constraints (heat rejection, packaging . . . ). This paper shows the importance of the modeling phase when designing WHRS and yields a better understanding when it comes to a vehicle integration of a Rankine cycle in a truck. [less ▲]

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See detailOptimizing the management of osteoarthritis-Transitioning evidence-based guidelines into practical guidance for real-world clinical practice
Reginster, Jean-Yves ULg; Cooper, C.

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 1-2

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See detailMechanically-coupled ring-resonator filter and array (analytical and finite element model).
Pachkawade, Vinayak ULg; Junghare, R; Patrikar, R et al

in IET Computers & Digital Techniques (2016)

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band ... [more ▼]

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band-pass filter with centre frequency of 4.4 MHz and a small bandwidth of only 36 kHz. Flexural-mode ring resonators have been mechanically coupled using soft mechanical spring for realising the filtering action. Owing to inherent symmetry in the ring structure, simple approach is used to access a low-velocity coupling locations to set a smallest possible bandwidth. The authors also show a reduction in the amplitude of spurious mode by accentuating the filter structure in its fully differential mode inherently present in the structure. Moreover, the effect of the number of the support beams and structural damping on the frequency response of a filter has been analysed. A second device is mechanically coupled ring-resonator arrays with varying number of rings coupled. The mechanical links using short stubs connect each constituent resonator of an array to its adjacent ones at the high-velocity vibrating locations to accentuate the desired mode and reject all other spurious modes. Both analytical and finite-element based simulation results for parameters of the designed structure are found in good agreement. [less ▲]

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See detailCore cross-linked micelles of polyphosphoester containing amphiphilic block copolymers as drug nanocarriers
Ergül, Zeynep ULg; Vanslambrouck, Stéphanie; Cajot, Sébastien et al

in RSC Advances (2016), 6(48), 42081-42088

Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the ... [more ▼]

Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the stability of the micelles at high dilution by crosslinking the hydrophobic polyphosphoester micellar core. Typically, an unsaturated alkene side-chain was introduced on the cyclic phosphate monomer according to a one-step reaction followed by its organocatalyzed polymerization initiated by a poly(ethylene oxide) macroinitiator. This strategy avoids the use of any organometallic compounds in order to facilitate the purification and meet the stringent requirements of biomedical applications. After self-assembly into water, the micelles were cross-linked by simple UV irradiation. These cross-linked micelles have then been loaded by doxorubicin to evaluate their potential as drug nanocarriers and monitor the impact of crosslinking on the release profile. [less ▲]

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See detailIL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis.
Humblet-Baron, Stephanie; Franckaert, Dean; Dooley, James et al

in Journal of Allergy and Clinical Immunology (The) (2016), 138(1), 200-2098

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic ... [more ▼]

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic lymphohistiocytosis (FHL) forms. In both conditions, a sterile or infectious trigger is required for disease initiation, which then becomes self-sustaining and life-threatening. Recent studies have attributed the key distal event to excessive IFN-gamma production; however, the proximal events driving immune dysregulation have remained undefined. OBJECTIVE: We sought to investigate the role of regulatory T (Treg) cells in the pathophysiology of experimental FHL. METHODS: Because mutation in perforin is a common cause of FHL, we used an experimental FHL mouse model in which disease in perforin-deficient mice is triggered by lymphocytic choriomeningitis virus (LCMV). We assessed Treg and CD8(+) T-cell homeostasis and activation during the changing systemic conditions in the mice. In addition, human blood samples were collected and analyzed during the HLH episode. RESULTS: We found no primary Treg cell defects in perforin-deficient mice. However, Treg cell numbers collapsed after LCMV inoculation. The collapse of Treg cell numbers in LCMV-triggered perforin-deficient, but not wild-type, mice was accompanied by the combination of lower IL-2 secretion by conventional CD4(+) T cells, increased IL-2 consumption by activated CD8(+) T cells, and secretion of competitive soluble CD25. Moreover low Treg cell numbers were observed in untreated patients experiencing HLH flares. CONCLUSION: These results demonstrate that excessive CD8(+) T-cell activation rewires the IL-2 homeostatic network away from Treg cell maintenance and toward feed-forward inflammation. These results also provide a potential mechanistic pathway for the progression of infectious inflammation to persistent inflammation in patients with HLH. [less ▲]

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See detailIdentifying mismatch between urban travel demand and transport network services using GPS data: A case study in the fast growing Chinese city of Harbin
Cui, JianXun; Liu, Feng; Hu, Jia et al

in Neurocomputing (2016), 181

The world's urban population growth and economic development have led to the reshaping of metropolitan space layouts among residential, employment and shopping locations, generating growing mismatch ... [more ▼]

The world's urban population growth and economic development have led to the reshaping of metropolitan space layouts among residential, employment and shopping locations, generating growing mismatch between travel demand and transport services. A reliable method to accurately analyze mobility demand and underlying transport network systems and to identify areas with serious mismatch problems is important for the design of effective policy measures. In this paper, we make use of the wide deployment of GPS devices in vehicles in many cities today, to develop such a method. This approach is developed using GPS data collected from all taxis operating in the Chinese city of Harbin between July and September in 2013. It consists of four major steps. First, city-wide mobility patterns are modeled based on GPS trajectories. This model captures a set of key traffic characteristics for each pair of regions in the entire urban network, including travel demand, travel speed and route directness of travel paths. From this model, a set of indicators is then built to measure the road transport performance between the regions, and the areas with serious mismatch problems are subsequently pinpointed. Finally, the identified problematic regions are further examined and specific transport problems are analyzed. By applying the proposed method to the city of Harbin, the potential and effectiveness of this method are demonstrated. Moreover, with more and more urban vehicles being equipped with GPS devices, the designed method can be easily transferred to other cities, thus paving a way for the adoption of the presented approach for an up-to-date and spatial-temporal sensitive road network analysis approach that supports the establishment of a more sustainable urban transport system. [less ▲]

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See detailLe couplage « Micro-crédit, Micro-assurance santé et Offre des soins » peut améliorer l’accessibilité aux soins de santé de qualité en milieu urbain africain : Résultats d’une expérience menée dans la zone de santé de Bandalungwa à Kinshasa, Congo.
Manzambi Kuwekita, Joseph ULg; Gosset, Christiane ULg; Guillaume, Michèle ULg et al

in Médecine et Santé Tropicales (2015), 25

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in ... [more ▼]

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in Kinshasa. The bivariate analysis shows a significant association between the increase in purchasing power and realization of benefit (p = 0, 001), achievement of benefit and savings (p = 0, 000) savings and insurance health and improved access to health care: according to the main results, 68.8 %t of borrowers reported an increase in their purchasing power which 81.8% making benefit. Those with savings were 24.7 times more likely to contribute to a health insurance scheme than those without; 71.9% of those who have regularly contributed to health insurance have improved their access to care. Coupling microcredit, health microinsurance and health care can improve access to quality health care at lower cost. This suggests the integration of health insurance in the primary health care system. [less ▲]

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See detailLe droit constitutionnel de la Principauté de Liège au 18e siècle
Behrendt, Christian ULg; Vandenbosch, Sofia ULg

in Revue Belge de Droit Constitutionnel [= RBDC] (2015), 2015

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See detailUn moment machiavélien dans la théorie. Sur Althusser
Oulc'hen, Hervé ULg

in Cahiers du GRM (2015), 8

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See detailFurther insights into the metamorphosis process in a carapid fish
Parmentier, Eric ULg

in Journal of Zoology (2015)

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See detailCirculating microRNA-based screening tool for breast cancer
Freres, Pierre ULg; Wenric, Stéphane ULg; Boukerroucha, Meriem et al

in Oncotarget (2015)

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative ... [more ▼]

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis. A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women. A diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors. A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81. The accuracy of the diagnostic tool remained unchanged considering age and tumor stage. The miRNA signature correctly identified patients with metastatic breast cancer. The use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group. Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer. [less ▲]

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See detailReconstruction of the envelope of non-Gaussian structural responses with principal static wind loads
Blaise, Nicolas ULg; Canor, Thomas; Denoël, Vincent ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2015), 149

In current practice, structural engineers commonly focus on the wind-resistant design by means of static wind loads. In case of non-Gaussianities, there is room for improvement to properly derive these ... [more ▼]

In current practice, structural engineers commonly focus on the wind-resistant design by means of static wind loads. In case of non-Gaussianities, there is room for improvement to properly derive these static loads. First, this paper extends in a non-Gaussian context the concept of the load-response correlation (LRC) method establishing equivalent static wind loads (ESWLs). This is done by a proper recourse to the new concept of conditional expected static wind load and a proposed bicubic model for the joint and conditional distribution functions. Second, this paper investigates the envelope reconstruction problem targeting the efficient reconstruction of the envelope values of a set of non-Gaussian structural responses by means of principal static wind loads (PSWLs). They have been introduced in a Gaussian context and are obtained by a singular value decomposition of ESWLs. This paper addresses the extension of PSWLs to non-Gaussian structural responses, as well. The developments apply to structures with a linear behavior and subjected to an aerodynamic pressure field exhibiting mildly to strongly non-Gaussian features. In this context, the well-known load-response correlation and conditional sampling methods are used for comparisons. This study is undertaken for quasi-static analysis of structures and is illustrated on a low-rise building. [less ▲]

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See detailAnticoherence of spin states with point-group symmetries
Baguette, Dorian ULg; Damanet, François ULg; Giraud, Olivier et al

in Physical Review A (2015), 92

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana ... [more ▼]

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana representation of spin states in terms of points on the unit sphere, we analyze the consequences of a point-group symmetry in their arrangement on the quantum properties of the corresponding state. We focus on the identification of anticoherent states (for which all reduced density matrices in the symmetric subspace are maximally mixed) associated with point-group-symmetric sets of points. We provide three different characterizations of anticoherence and establish a link between point symmetries, anticoherence, and classes of states equivalent through stochastic local operations with classical communication. We then investigate in detail the case of small numbers of qubits and construct infinite families of anticoherent states with point-group symmetry of their Majorana points, showing that anticoherent states do exist to arbitrary order. [less ▲]

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See detailUne première histoire des réfugiés juifs de Belgique (1945-1948)
Grandjean, Geoffrey ULg

in Cahiers Mémoire et Politique (2015), 3

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See detailCahiers Mémoire et Politique
Grandjean, Geoffrey ULg

in Cahiers Mémoire et Politique (2015), 3

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See detailSkin ultrastructural similarities between fibromyalgia and Ehlers-Danlos syndrome hypermobility type
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg

in Journal of osteoarthritis (2015), 1(1),

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established ... [more ▼]

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established. The physical changes observed in the mechanical properties of skin and joints do not distinctly distinguish these disorders. In addition, similar ultrastructural dermal changes are observed in both EDSH and some FM cases. The molecular alterations remain largely undisclosed in both diseases. As a result, EDSH remains undiagnosed in some FM patients. This condition deteriorates quality of life and possibly leads to prominent health problems. [less ▲]

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See detailDendroécologie du hêtre en forêt de Soignes : Les cernes des arbres nous renseignent sur les changements récents et futurs
Latte, Nicolas ULg; Kint, Vincent; Drouet, Thomas et al

in FORÊT.NATURE (2015), 137(Octobre-Novembre-Décembre), 24-37

La dendroécologie combine la dendrochronologie et l’écologie forestière. Elle a permis d’analyser les cernes des hêtres de la forêt de Soignes et de comparer les tendances dans le contexte plus large des ... [more ▼]

La dendroécologie combine la dendrochronologie et l’écologie forestière. Elle a permis d’analyser les cernes des hêtres de la forêt de Soignes et de comparer les tendances dans le contexte plus large des hêtraies de Belgique. Depuis la fin des années ‘70, le hêtre devient de plus en plus sensible au climat, surtout en Soignes. L’augmentation de la fréquence et de l’intensité des sécheresses printanières et des canicules ont affecté négativement la croissance annuelle des hêtres. Les prévisions climatiques pour le 21e siècle présage une rapide aggravation. Les risques encourus par l’essence aboutissent à de nouvelles réflexions sur la gestion de la hêtraie de Soignes. Pour les peuplements existants : une sylviculture dynamique avec des éclaircies fortes et fréquentes afin de limiter la concurrence pour les ressources et favoriser la croissance individuelle des arbres. Pour la régénération des vieilles hêtraies : les remplacer par d’autres essences plus tolérantes ou favoriser le mélange et confiner le hêtre aux surfaces limitées des stations les plus fraîches. Un risque mesuré pourrait être pris en regard du rôle patrimonial des hêtraies cathédrales en Soignes. Toutefois, ce faciès peut être obtenu avec d’autres essences. [less ▲]

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See detailReal-time measurement of temperature variation during nanosecond pulsed laser induced contamination deposition
Kokkinos, Dimitrios ULg; Gailly, Patrick ULg; Georges, Marc ULg et al

in Applied Optics (2015), 54(36), 10579

In this paper a study of the heat generation during UV Laser Induced Contamination (LIC) and potentially resulting subsequent thermal damage is presented. This becomes increasingly interesting when optics ... [more ▼]

In this paper a study of the heat generation during UV Laser Induced Contamination (LIC) and potentially resulting subsequent thermal damage is presented. This becomes increasingly interesting when optics with delicate coatings are involved. During LIC radiation can interact with outgassing molecules both in the gas phase and at the surface, triggering chemical and photo-fixation reactions. This is a major hazard, in particular for laser units operating under vacuum conditions such as for space applications. The intense photon flux not only affects the contaminant deposition rate but also alters their chemical structure that can increase their absorption coefficient. Over cumulative irradiation shots these molecules formed deposits that increasingly absorb photons and produce heat as a by-product of de-excitation eventually leading to thermal damage. One could better asses the risk of the latter with the knowledge of temperature during the contamination process. For this purpose thermoreflectance technique is used here to estimate the temperature variation from pulse to pulse during contamination deposition through the analysis of a temperature-dependent surface reflectance signal. [less ▲]

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See detailPrediction of the post-dilution hematocrit during cardiopulmonary bypass. Are new formulas needed?
ERPICUM, Marie ULg; Dardenne, Nadia ULg; HANS, Grégory ULg et al

in Perfusion (2015)

Objectives: Predicting the post-dilution hematocrit is an important tool to avoid preventable anemia or unnecessary transfusion. Simplified empirical formulas currently used for such a prediction may lead ... [more ▼]

Objectives: Predicting the post-dilution hematocrit is an important tool to avoid preventable anemia or unnecessary transfusion. Simplified empirical formulas currently used for such a prediction may lead to large errors. We aimed to improve the accuracy of these formulas by a better estimation of the dilution volume and the patient circulatory blood volume. Methods: We compared the estimation accuracy of two formulas, using fixed (formula A) versus estimated (formula D) dilution volume and patient circulatory blood volume for 100 cardiac interventions. The difference between predicted and measured HctT1 was considered as “good” if less than 0.5%, “moderate” between 0.5 and 2% and “poor” if higher than 2%. The influence of the body mass index (BMI) on patient blood volume estimation was explored by categorized groups’ comparison. Results: The mean difference between predicted and measured HctT1 differed significantly between formulas A and D. Formula A didn’t differ from HctT1 (p=0.19, IC95% [-0.89-0.18]), but a significant and higher underestimation was observed in the BMI⩽25 group compared to the other BMI groups (p<0.001). Formula D overestimated HctT1 (p<0.001, IC95% [1.01-1.93]) without a difference between the BMI groups. No difference was observed in their overall proportions of good (11 vs 10%), moderate (44 vs 46%) and poor predictions (47 vs 44%) (p=0.117). Conclusions: Formulas used for post-dilution hematocrit prediction lead to major estimation errors and a risk of inadequate transfusion practices. Estimations performed by experienced clinicians could not minimize these biases in all clinical cases as significant errors remain, with potential clinical impact. No estimation formula should be used as a hard tool for transfusing patients, but rather as a guide to predicting the probability of transfusion requirement. [less ▲]

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See detailMannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study.
Mandal, Jyotshna; Malla, Bijaya; Steffensen, Rudi et al

in Respiratory research (2015), 16

BACKGROUND: Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and ... [more ▼]

BACKGROUND: Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and circulating MBL protein levels are associated with clinically relevant outcomes in the Predicting Outcome using systemic Markers In Severe Exacerbations of COPD PROMISE-COPD cohort. METHODS: We followed 277 patients with stable COPD GOLD stage II-IV COPD over a median period of 733 days (IQR 641-767) taking survival as the primary outcome parameter. Patients were dichotomized as frequent (>/= 2 AECOPD/year) or infrequent exacerbators. Serum MBL levels and single nucleotide polymorphisms of the MBL2 gene were assessed at baseline. RESULTS: The MBL2-HYPD haplotype was significantly more prevalent in frequent exacerbators (OR: 3.33; 95% CI, 1.24-7.14, p = 0.01). The median serum MBL concentration was similar in frequent (607 ng/ml, [IQR; 363.0-896.0 ng/ml]) and infrequent exacerbators (615 ng/ml, [IQR; 371.0-942.0 ng/ml]). Serum MBL was not associated with lung function characteristics or bacterial colonization in sputum. However, high serum MBL at stable state was associated with better survival compared to low MBL (p = 0.046, log rank test). CONCLUSIONS: In COPD, the HYPD haplotype of MBL2 gene is associated with frequent exacerbations and high serum MBL is linked to increased survival. The PROMISE-COPD study was registered at www.controlled-trials.com under the identifier ISRCTN99586989. [less ▲]

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See detailWater-Energy Nexus in Shared River Basins: How Hydropower Shapes Cooperation and Coordination
Kouangpalath, Phimthong ULg; Meijer, Karen

in Change and Adaptation in Socio-Ecological Systems (2015), 2(1), 85-87

The construction of hydropower plants on transboundary rivers is seldom done with equal benefits to all riparians, and therefore presents coordination and cooperation challenges. Without a supra-national ... [more ▼]

The construction of hydropower plants on transboundary rivers is seldom done with equal benefits to all riparians, and therefore presents coordination and cooperation challenges. Without a supra-national authority in charge of transboundary river basins, coordination between sectors (water, energy and environment) and cooperation between countries largely depends on willingness of the individual nation states and the power relations between these countries. This paper discusses how the interests and relative power positions of actors in transboundary water management shape the outcomes, and what roles are played by River Basin Organisations and foreign investors (especially in hydropower development). These issues are illustrated with examples from the Mekong river in Southeast Asia (Laos, Thailand, Cambodia and Vietnam), the Euphrates-Tigris (Turkey, Syria, Iraq, Iran and Kuwait) and the Çoruh in Turkey and Georgia. [less ▲]

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See detailChirurgie fine
Dawance, Sophie ULg

in A+: revue d'architecture (2015), 257

Le Complexe sportif de l’Université de Liège au Sart Tilman se déploie sur le coteau du ruisseau du Blanc Gravier. La rénovation des deux ensembles bâtis qui le composent – le Centre sportif construit par ... [more ▼]

Le Complexe sportif de l’Université de Liège au Sart Tilman se déploie sur le coteau du ruisseau du Blanc Gravier. La rénovation des deux ensembles bâtis qui le composent – le Centre sportif construit par Charles Vandenhove entre 1961 et 1971 et le Blanc Gravier, œuvre de Bruno Albert édifié entre 1978 et 1981 – est à l’ordre du jour. [less ▲]

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See detailL'Italia e i processi di decolonizzazione : il caso del Congo belga (1957-1960)
Genin, Vincent ULg

in Ventunesimo Secolo (2015), 36(Anno XIV (Giugno 2015)), 105-138

This article, based on unpusblished archives, is devoted to the question : what was the impact of the decolonization of the Belgian Congo on Italian foreign Policy ((1957-1960) ? Facing a shared reality ... [more ▼]

This article, based on unpusblished archives, is devoted to the question : what was the impact of the decolonization of the Belgian Congo on Italian foreign Policy ((1957-1960) ? Facing a shared reality with Belgium, the aim of this research is to study the attitude of Italian foreign policy, forced to maintain a balance between its position in the UN ; its relation with Belgium ; and the need to maintain influence, mainly through Financial penetration, in the newly independent Congo [less ▲]

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See detailPublic health impact and cost-effectiveness of dairy products supplemented with vitamin D in prevention of osteoporotic fractures
Ethgen, Olivier ULg; Hiligsmann, Mickaël; Burlet, Nansa et al

in Archives of Public Health (2015)

Background: Dietary sources of calcium and vitamin D are recommended as a first-line strategy in prevention of osteoporosis-related fractures but their public health and economic impact has never been ... [more ▼]

Background: Dietary sources of calcium and vitamin D are recommended as a first-line strategy in prevention of osteoporosis-related fractures but their public health and economic impact has never been studied. Methods: We designed a population-based model to forecast the potential health outcomes and medical effectiveness of the daily administration of dairy supplements containing 800 IU of vitamin D and 1 g of calcium in cohorts of subjects, from both genders, aged 50, 60, 70 and 80 years. Annual costs of dairy products were tested at €150, €250 and €350. Results: In total, the daily intake of vitamin-D rich dairy products reduces by 30,376 and 16,105 events the number of osteoporotic fractures in women and men respectively and permits to gain 6605 and 6144 life-years, in women and men respectively. This intervention is cost-effective from 70 years on in the general population and from 60 years on in patients at increased risk of osteoporotic fractures. Conclusion: The recommendation to use dairy products as the preferred source of calcium and vitamin D in aging males and females is supported by public health and health economic analyses. [less ▲]

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See detailLe droit de rétrocession, une garantie constitutionnelle pour l'exproprié?
Vrancken, Martin ULg; Pâques, Michel ULg

in Administration Publique: Revue du Droit Public et des Sciences Administratives (2015)

Revue de droit public et des sciences administratives

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See detailIntegration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer
Pineda San Juan, Silvia ULg; Real, Francisco X; Kogevinas, Manolis et al

in PLoS Genetics (2015)

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See detailImpact of cyclonic and anticyclonic activity on Greenland ice sheet surface mass balance variation during 1980–2013
Chen, L.; Fettweis, Xavier ULg; Knudsen, E. et al

in International Journal of Climatology (2015)

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective ... [more ▼]

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective, extratropical cyclones and anticyclones are the major systems influencing Greenland weather conditions. Seasonal cyclonic and anticyclonic activities have been quantified for the area of 50°–90°N, 80°W–10°E during 1980–2013. Based on a singular value decomposition (SVD) analysis, we investigated the role of synoptic scale cyclonic and anticyclonic activities in determining snow accumulation (SA) and surface air temperature (SAT). Thus, the SA-driven and melt-driven SMB variability has been determined. SA-related synoptic patterns identified from the leading and the second SVD modes explain up to 80% of the inter-annual SMB variance, especially in southern and northwestern Greenland, where we found the largest and second largest amount of annual SA. SAT-related patterns account for up to 80% of the inter-annual SMB variation along the west and northwest coast of Greenland, where significant surface mass loss has been observed over the last decades. It should be noted that the negative phase of the SA-related pattern derived from the first SVD mode in June-July-August and the positive phase of the SAT-related (anti)cyclonic patterns have occurred more frequently since 2005, meaning that the phase change of these patterns has made a major contribution to the accelerated GrIS surface ice loss during recent years. [less ▲]

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See detailSerum calcitriol concentrations measured with a new direct automated assay in a large population of adult healthy subjects and in various clinical situations
Souberbielle, JC; CAVALIER, Etienne ULg; DELANAYE, Pierre ULg et al

in Clinica Chimica Acta (2015), 451 (Pt B)

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol ... [more ▼]

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol with a new automated direct assay on the Liaison XL platform in 888 healthy French Caucasian subjects aged 18–89 years, 32 patients with a surgically-proven PHPT, 32 pregnant women at the end of the first and at the end of the third trimester, and 24 dialysis patients before and after one year of supplementationwith vitamin D3 or placebo. The mean calcitriol concentration (±SD) in the healthy population was 52.9 ± 14.5 ng/L with a 95% CI interval of 29–83.6 ng/L. In PHPT patients, calcitriol concentration was 81.6±29.0 ng/L, 15 of them (46.9%) having a concentration N83.6 ng/L. In pregnant women, calcitriol was 80.4 ± 26.4 ng/L at the end of the first trimester, and 113.1±33.0 ng/L at the end of the third trimester, 12 (37.5%) and 26 (81.3%) of them having a calcitriol concentration N83.6 ng/L at the first and third trimesters respectively. In 14 dialysis patients, calcitriol was 9.5±7.7 ng/L and rose to 19.3 ng/L after one year of supplementation with 50,000 IU vitamin D3/month. In 10 other dialysis patients, calcitriol was 9.9±2.9 ng/L and remained stable (12.4±3.7 ng/L) after one year of placebo. In conclusion, this new automated calcitriol assay, in addition to presenting excellent analytical performances, gives the expected variations in patients compared to “normal” values obtained in an extensive reference population [less ▲]

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See detailFraming the Concept of Citizenship in a Contested Nation-State: Reflections on Kosovo
Mazur Kumric, Nives ULg

in Pécs Journal of International and European Law (2015), (II), 70-88

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty ... [more ▼]

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty, perplexed inter-ethnic relations, profound international interference and parallel jurisdictions with the Republic of Serbia. The efforts put forth to conceptualise the meaning and scope of Kosovo citizenship in such a sensitive socio-political environment have proved particularly challenging. This paper aims to provide an analytical framework for determining essential elements of Kosovo citizenship, with particular emphasis on its practical and ideological implications for the multicultural, yet ethnically divided society. This is done through an assessment of the key nation-constituting legal norms as well as the deep-rooted ethnic tensions sparked by conflicting perceptions of Kosovo's statehood by the majority (Kosovo Albanian) and minority (Kosovo Serbian) population. By formal definition, Kosovo is an indivisible state of all citizens, however, polarised majority-minority interests have impinged the constitutionally guaranteed civic spirit of the entity, thereby threatening not only national, but also wider international security and integrity. With the purpose of determining and delineating labyrinthine intersections of a contested nation-state, citizenship, 'communities' and security, the paper offers a comprehensive theoretical analysis of the respective quadrilateral nexus. [less ▲]

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See detailInfluence of process operating conditions on solvent thermal and oxidative degradation in post-combustion CO2 capture
Léonard, Grégoire ULg; Crosset, Cyril; Toye, Dominique ULg et al

in Computers & Chemical Engineering (2015), 83

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data ... [more ▼]

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data, monoethanolamine degradation is included into a CO2 capture process model. The influence of operating conditions on solvent loss is validated with pilot plant data from literature. Predicted solvent consumption rates are in better agreement with plant data than any previous work, and pathways are discussed to further refine the model. Oxidative degradation in the absorber is the largest cause of solvent loss while thermal degradation does not appear as a major concern. Using a single model, the process exergy requirement decreases by 10.8% and the solvent loss by 11.1% compared to our base case. As a result, this model provides a practical tool to simultaneously minimize the process energy requirement and the solvent consumption in post-combustion CO2 capture plants with amine solvents. [less ▲]

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See detailAssessing the O2 budget under sea ice: An experimental and modelling approach
Moreau, S.; Kaartokallio, H.; Vancoppenolle, M. et al

in Elementa: Science of the Anthropocene (2015), 3(000080),

The objective of this study was to assess the O2 budget in the water under sea ice combining observations and modelling. Modelling was used to discriminate between physical processes, gas-specific ... [more ▼]

The objective of this study was to assess the O2 budget in the water under sea ice combining observations and modelling. Modelling was used to discriminate between physical processes, gas-specific transport (i.e., ice-atmosphere gas fluxes and gas bubble buoyancy) and bacterial respiration (BR) and to constrain bacterial growth efficiency (BGE). A module describing the changes of the under-ice water properties, due to brine rejection and temperature-dependent BR, was implemented in the one-dimensional halo-thermodynamic sea ice model LIM1D. Our results show that BR was the dominant biogeochemical driver of O2 concentration in the water under ice (in a system without primary producers), followed by gas specific transport. The model suggests that the actual contribution of BR and gas specific transport to the change in seawater O2 concentration was 37% during ice growth and 48% during melt. BGE in the water under sea ice, as retrieved from the simulated O2 budget, was found to be between 0.4 and 0.5, which is in line with published BGE values for cold marine waters. Given the importance of BR to seawater O2 in the present study, it can be assumed that bacteria contribute substantially to organic matter consumption and gas fluxes in ice-covered polar oceans. In addition, we propose a parameterization of polar marine bacterial respiration, based on the strong temperature dependence of bacterial respiration and the high growth efficiency observed here, for further biogeochemical ocean modelling applications, such as regional or large-scale Earth System models [less ▲]

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See detailAutosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8.
Boycott, Kym M.; Beaulieu, Chandree L.; Kernohan, Kristin D. et al

in American journal of human genetics (2015), 97(6), 886-93

Manganese (Mn) and zinc (Zn) are essential divalent cations used by cells as protein cofactors; various human studies and animal models have demonstrated the importance of Mn and Zn for development. Here ... [more ▼]

Manganese (Mn) and zinc (Zn) are essential divalent cations used by cells as protein cofactors; various human studies and animal models have demonstrated the importance of Mn and Zn for development. Here we describe an autosomal-recessive disorder in six individuals from the Hutterite community and in an unrelated Egyptian sibpair; the disorder is characterized by intellectual disability, developmental delay, hypotonia, strabismus, cerebellar atrophy, and variable short stature. Exome sequencing in one affected Hutterite individual and the Egyptian family identified the same homozygous variant, c.112G>C (p.Gly38Arg), affecting a conserved residue of SLC39A8. The affected Hutterite and Egyptian individuals did not share an extended common haplotype, suggesting that the mutation arose independently. SLC39A8 is a member of the solute carrier gene family known to import Mn, Zn, and other divalent cations across the plasma membrane. Evaluation of these two metal ions in the affected individuals revealed variably low levels of Mn and Zn in blood and elevated levels in urine, indicating renal wasting. Our findings identify a human Mn and Zn transporter deficiency syndrome linked to SLC39A8, providing insight into the roles of Mn and Zn homeostasis in human health and development. [less ▲]

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See detailThe return of Turkey to the Western Balkans: a challenge or an opportunity for the European Union?
Lika, Liridon ULg

in Politikon: IAPSS Journal of Political Science (2015)

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See detailEvolution of the Northern Rockweed, Fucus distichus, in a Regime of Glacial Cycling: Implications for Benthic Algal Phylogenetics
Laughinghouse, Haywood, Dail; Müller, Kirsten; Adey, Walter et al

in PLoS ONE (2015), 10(12), 0143795

Northern hemisphere rockweeds (Fucus) are thought to have evolved in the North Pacific and then spread to the North Atlantic following the opening of the Bering Strait. They have dispersed and widely ... [more ▼]

Northern hemisphere rockweeds (Fucus) are thought to have evolved in the North Pacific and then spread to the North Atlantic following the opening of the Bering Strait. They have dispersed and widely speciated in the North Atlantic and its tributary seas. Fucus distichus is likely near the ancestral member of this genus, and studies have shown that there are several species/subspecies in this complex (i.e. F. evanescens and F. gardneri). We used phylogenetic and haplotype analyses to test the phylogenetic relationships and biogeogra- phy of F. distichus. Our data and subsequent analyses demonstrate that, unlike previous studies that lacked samples from an extensive geographical area of the Arctic and Subarc- tic, there is a distinct Arctic haplotype that is the source of subspecies in both the North Pacific and North Atlantic. Fucus distichus occupies a low tide zone habitat, and in Arctic/ Subarctic regions it is adapted to the severe stress of sea ice coverage and disturbance dur- ing many months per year. We hypothesize that the very large geographic area of Arctic and Subarctic rocky shores available to this species during interglacials, supported by large Arctic/Subarctic fringe areas as well as unglaciated refugia during glacial cycles, provided a robust population and gene pool (described by the Thermogeographic Model). This gene pool dilutes that of the more fragmented and area-limited Temperate/Boreal area popula- tions when they are brought together during glacial cycles. We suggest that similar subspe- cies complexes for a variety of Arctic/Subarctic shore biota should be examined further in this context, rather than arbitrarily being split up into numerous species. [less ▲]

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See detailAnalytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines
Habyalimana, Védaste ULg; Mbinze Kindenge, Jérémie; Kalenda Tshilombo, Nicodème ULg et al

in American Journal of Analytical Chemistry (2015), 6

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in ... [more ▼]

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and analytical tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several analytical techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chemical characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex analytical techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various analytical tools that can be used in detecting and identifying unknown component in poor quality medicines. [less ▲]

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See detailKroniek van het Nederlandse nationaliteitsrecht 2014-2015
Vonk, Olivier ULg

in Asiel- en Migrantenrecht (2015)

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See detailTRAPPIST photometry and imaging monitoring of comet C/2013 R1 (Lovejoy): Implications for the origin of daughter species
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2015), 584

We report the results of the narrow-band photometry and imaging monitoring of comet C/2013 R1 (Lovejoy) with the robotic telescope TRAPPIST (La Silla observatory). We gathered around 400 images over 8 ... [more ▼]

We report the results of the narrow-band photometry and imaging monitoring of comet C/2013 R1 (Lovejoy) with the robotic telescope TRAPPIST (La Silla observatory). We gathered around 400 images over 8 months pre- and post-perihelion between September 12, 2013 and July 6, 2014. We followed the evolution of the OH, NH, CN, C[SUB]3[/SUB], and C[SUB]2[/SUB] production rates computed with the Haser model, as well as the evolution of the dust production. All five gas species display an asymmetry about perihelion, since the rate of brightening is steeper than the rate of fading. The study of the coma morphology reveals gas and dust jets that indicate one or several active zone(s) on the nucleus. The dust, C[SUB]2[/SUB], and C[SUB]3[/SUB] morphologies present some similarities, while the CN morphology is different. OH and NH are enhanced in the tail direction. The study of the evolution of the comet activity shows that the OH, NH, and C[SUB]2[/SUB] production rate evolution with the heliocentric distance is correlated to the dust evolution. The CN and, to a lesser extent, the C[SUB]3[/SUB] do not display such a correlation with the dust. This evidence and the comparison with parent species production rates indicate that C[SUB]2[/SUB] and C[SUB]3[/SUB], on one hand, and OH and NH, on the other, could be - at least partially - released from organic - rich grains and icy grains. On the contrary, all evidences point to HCN being the main parent of CN in this comet. [less ▲]

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See detailInteraction Between Convection and Pulsation
Houdek, Günter; Dupret, Marc-Antoine ULg

in Living Reviews in Solar Physics (2015), 12

This article reviews our current understanding of modelling convection dynamics in stars. Several semi-analytical time-dependent convection models have been proposed for pulsating one-dimensional stellar ... [more ▼]

This article reviews our current understanding of modelling convection dynamics in stars. Several semi-analytical time-dependent convection models have been proposed for pulsating one-dimensional stellar structures with different formulations for how the convective turbulent velocity field couples with the global stellar oscillations. In this review we put emphasis on two, widely used, time-dependent convection formulations for estimating pulsation properties in one-dimensional stellar models. Applications to pulsating stars are presented with results for oscillation properties, such as the effects of convection dynamics on the oscillation frequencies, or the stability of pulsation modes, in classical pulsators and in stars supporting solar-type oscillations. [less ▲]

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See detailLarger and faster: revised properties and a shorter orbital period for the WASP-57 planetary system from a pro-am collaboration
Southworth, John; Mancini, L.; Tregloan-Reed, J. et al

in Monthly Notices of the Royal Astronomical Society (2015), 454

Transits in the WASP-57 planetary system have been found to occur half an hour earlier than expected. We present 10 transit light curves from amateur telescopes, on which this discovery was based, 13 ... [more ▼]

Transits in the WASP-57 planetary system have been found to occur half an hour earlier than expected. We present 10 transit light curves from amateur telescopes, on which this discovery was based, 13 transit light curves from professional facilities which confirm and refine this finding, and high-resolution imaging which show no evidence for nearby companions. We use these data to determine a new and precise orbital ephemeris, and measure the physical properties of the system. Our revised orbital period is 4.5 s shorter than found from the discovery data alone, which explains the early occurrence of the transits. We also find both the star and planet to be larger and less massive than previously thought. The measured mass and radius of the planet are now consistent with theoretical models of gas giants containing no heavy-element core, as expected for the subsolar metallicity of the host star. Two transits were observed simultaneously in four passbands. We use the resulting light curves to measure the planet's radius as a function of wavelength, finding that our data are sufficient in principle but not in practise to constrain its atmospheric properties. We conclude with a discussion of the current and future status of transmission photometry studies for probing the atmospheres of gas-giant transiting planets. [less ▲]

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See detailLes lieux d’habitation des écrivains belges francophones à Bruxelles (1930-1960). Premiers jalons pour une histoire sociogéographique
Debroux, Tatiana; Vanderpelen-Diagre, Cécile; Dozo, Björn-Olav ULg

in Textyles : Revue des Lettres Belges de Langue Française (2015), 47

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See detailThe HARPS-N Rocky Planet Search. I. HD 219134 b: A transiting rocky planet in a multi-planet system at 6.5 pc from the Sun
Motalebi, F.; Udry, S.; Gillon, Michaël ULg et al

in Astronomy and Astrophysics (2015), 584

We know now from radial velocity surveys and transit space missions that planets only a few times more massive than our Earth are frequent around solar-type stars. Fundamental questions about their ... [more ▼]

We know now from radial velocity surveys and transit space missions that planets only a few times more massive than our Earth are frequent around solar-type stars. Fundamental questions about their formation history, physical properties, internal structure, and atmosphere composition are, however, still to be solved. We present here the detection of a system of four low-mass planets around the bright (V = 5.5) and close-by (6.5 pc) star HD 219134. This is the first result of the Rocky Planet Search programme with HARPS-N on the Telescopio Nazionale Galileo in La Palma. The inner planet orbits the star in 3.0935 ± 0.0003 days, on a quasi-circular orbit with a semi-major axis of 0.0382 ± 0.0003 AU. Spitzer observations allowed us to detect the transit of the planet in front of the star making HD 219134 b the nearest known transiting planet to date. From the amplitude of the radial velocity variation (2.25 ± 0.22 ms[SUP]-1[/SUP]) and observed depth of the transit (359 ± 38 ppm), the planet mass and radius are estimated to be 4.36 ± 0.44 M[SUB]⊕[/SUB] and 1.606 ± 0.086 R[SUB]⊕[/SUB], leading to a mean density of 5.76 ± 1.09 g cm[SUP]-3[/SUP], suggesting a rocky composition. One additional planet with minimum-mass of 2.78 ± 0.65 M[SUB]⊕[/SUB] moves on a close-in, quasi-circular orbit with a period of 6.767 ± 0.004 days. The third planet in the system has a period of 46.66 ± 0.08 days and a minimum-mass of 8.94 ± 1.13 M[SUB]⊕[/SUB], at 0.233 ± 0.002 AU from the star. Its eccentricity is 0.46 ± 0.11. The period of this planet is close to the rotational period of the star estimated from variations of activity indicators (42.3 ± 0.1 days). The planetary origin of the signal is, however, thepreferred solution as no indication of variation at the corresponding frequency is observed for activity-sensitive parameters. Finally, a fourth additional longer-period planet of mass of 71 M[SUB]⊕[/SUB] orbits the star in 1842 days, on an eccentric orbit (e = 0.34 ± 0.17) at a distance of 2.56 AU. The photometric time series and radial velocities used in this work are available in electronic form at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/584/A72">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/584/A72</A> [less ▲]

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See detailPolarization microlensing in the quadruply imaged broad absorption line quasar H1413+117
Hutsemekers, Damien ULg; Sluse, Dominique ULg; Braibant, Lorraine ULg et al

in Astronomy and Astrophysics (2015), 584

We have obtained spectropolarimetric observations of the four images of the gravitationally lensed broad absorption line quasar H1413+117. The polarization of the microlensed image D is significantly ... [more ▼]

We have obtained spectropolarimetric observations of the four images of the gravitationally lensed broad absorption line quasar H1413+117. The polarization of the microlensed image D is significantly different, both in the continuum and in the broad lines, from the polarization of image A, which is essentially unaffected by microlensing. The observations suggest that the continuum is scattered off two regions, spatially separated, and producing roughly perpendicular polarizations. These results are compatible with a model in which the microlensed polarized continuum comes from a compact region located in the equatorial plane close to the accretion disk and the non-microlensed continuum from an extended region located along the polar axis. Based on observations made with ESO Telescopes at the Paranal Observatory (Chile). ESO program ID: 386.B-0337. [less ▲]

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See detailDrug-polymer electrostatic complexes as new structuring agents for the formation of drug-loaded ordered mesoporous silica
Molina, Emilie; Warnant, Jérôme; Mathonnat, Mélody et al

in Langmuir (2015), 31(47), 12839-12844

Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases ... [more ▼]

Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behaviour was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors and, this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multi-step processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials. [less ▲]

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See detailA cross-sectional study to evaluate factors related to condom use with commercial sexual partners in workers from Ecuadorian companies
Cabezas, Maria C.; Fornasini, Marco; Dardenne, Nadia ULg et al

in BMC Public Health (2015), 15(1),

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See detailVan botscan tot bodysuit. Naar een maatschappelijk debat over sportinnovatie
Van Oudheusden, Michiel ULg; Van Hoyweghen, Ine

in Karakter. Tijdschrift van wetenschap (2015), 52

Many scientists, athletes, sports bodies, and governments applaud the increasing integration of science and technology into sports. However, the scientization of sports raises ethical, legal, and social ... [more ▼]

Many scientists, athletes, sports bodies, and governments applaud the increasing integration of science and technology into sports. However, the scientization of sports raises ethical, legal, and social issues (ELSI), e.g. about the changing relationship between medical support and human enhancement, and the implications of scientific talent screening in sports for sports participation. A public debate is needed that identifies the ELSI in sports innovation and urges technology innovators, regulators, and decision makers to take into account such issues before sports innovations are irrevocably locked into sports and society. [less ▲]

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See detailServing the general interest with public enterprises. New forms of governance and trends in ownership
Fecher-Bourgeois, Fabienne ULg; Bance, Philippe; Obermann, Gabriel

in Annals of Public and Cooperative Economics (2015), 86(4), 529-718

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See detailIs the O2(a1Δg) Venus nightglow emission controlled by solar activity ?
Soret, Lauriane ULg; Gérard, Jean-Claude ULg

in Icarus (2015), 262

Several past studies showed that the O2(a1Δg) Venus nightglow emission at 1.27 μm is highly variable on a timescale of hours. We examine whether the intensity of this emission shows a more global trend ... [more ▼]

Several past studies showed that the O2(a1Δg) Venus nightglow emission at 1.27 μm is highly variable on a timescale of hours. We examine whether the intensity of this emission shows a more global trend linked to solar activity. [less ▲]

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See detailContraception et risque carcinologique
BELIARD, Aude ULg

in Réalités en Gynécologie-Obstétrique (2015), 179

Hormonal contraception is used by millions of women worldwide for many years. Is there any impact on cancer risks (breast, ovarian, endometrial, cervical, liver, and colon cancer)? On the other hand, as a ... [more ▼]

Hormonal contraception is used by millions of women worldwide for many years. Is there any impact on cancer risks (breast, ovarian, endometrial, cervical, liver, and colon cancer)? On the other hand, as a result of advances in cancer therapy, women within the reproductive-aged group are more likely to survive cancer and be interested to procreate or to delay pregnancy. Which method of contraception can be proposed to this special population of cancer patients? [less ▲]

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See detailLa vie littéraire au kaléidoscope des Physiologies
Stienon, Valérie ULg

in Site de la Société des Études romantiques et dix-neuviémistes (SERD) (2015)

En mots et en vignettes, la Physiologie littéraire de la monarchie de Juillet élabore ses propres modalités de mise en fiction de la société. Selon un point de vue à la fois avisé et distancié, induit par ... [more ▼]

En mots et en vignettes, la Physiologie littéraire de la monarchie de Juillet élabore ses propres modalités de mise en fiction de la société. Selon un point de vue à la fois avisé et distancié, induit par l’association d’une centralité culturelle parisienne et d’une faible légitimité à l’ombre de la grande littérature, ces petites monographies réorganisent le système des valeurs à travers lesquelles est perçu le fait littéraire à leur époque. C’est l’occasion d’investiguer sur les à-côtés de la littérature, en interrogeant les manières de circonscrire le territoire des lettres et de le faire interagir avec d’autres domaines d’activités. Deux questions font plus particulièrement l’objet de cet article. D'une part, ces textes livrent-ils un traitement englobant et univoque du profil de l’homme de lettres ou s’attachent-ils au contraire à en souligner les nuances et les singularités en multipliant ses variétés, autour de la dichotomie bien connue des figures archétypales du poète et du journaliste ? D'autre part, dans quelle mesure ces textes reconduisent-ils le mythe du génie créateur et les valeurs romantiques du talent et de l’inspiration, compte tenu du fait que celles-ci sont difficilement compatibles avec les stratégies du parvenu et les expédients du jeune auteur pressé d’arriver, ruses que les Physiologies s’appliquent à débusquer, dans la foulée d’une abondante thématisation du macairisme et des fourberies du floueur ? [less ▲]

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See detailVers une démarche entrepreneuriale de l’aide canadienne au développement
WCusson, Gabrielle ULg

in Revue de la Faculté de Droit de l'Université de Liège (2015), 3

Depuis l’arrivée au pouvoir du gouvernement conservateur de Stephen Harper en 2007, l’aide canadienne au développement a subi plusieurs changements, tant aux niveaux de la nature des interventions, du ... [more ▼]

Depuis l’arrivée au pouvoir du gouvernement conservateur de Stephen Harper en 2007, l’aide canadienne au développement a subi plusieurs changements, tant aux niveaux de la nature des interventions, du financement des projets, des relations avec les différents partenaires du développement, de l’orientation ainsi que des modes de gestion de l’aide. En 2013, Ottawa a annoncé la fusion de l’Agence canadienne au développement international (ACDI) au ministère des Affaires étrangères et du Commerce international (MAECI) au nom d’une plus grande cohérence des politiques et d’une plus grande efficacité des résultats. Alors que certains y perçoivent une réelle opportunité de réformer l’ensemble de la politique canadienne pour le développement, plusieurs reconnaissent une stratégie pour aligner l’aide sur les intérêts commerciaux et diplomatiques du Canada. L’aide canadienne au développement subit indéniablement une réorientation et une remise en question profonde de ses buts, de ses objectifs et de ses principes fondamentaux. Dans cette optique, cet article présente une analyse susceptible de vérifier si la réorientation de l’aide canadienne au développement depuis l’arrivée du gouvernement Harper [less ▲]

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See detailAn overview of the plastic‑hinge analysis of 3D steel frames
Hoang, Van Long ULg; Nguyen, Dang-Hung; Jaspart, Jean-Pierre ULg et al

in Asia Pacific Journal on Computational Engineering (2015), 2:4

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See detailRegards croisés entre le Portugal et la Wallonie
Belche, Jean ULg; Sousa, Alexandra

in Santé Conjuguée (2015), 73

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See detailEmerging ecosystem services governance issues in the Belgium ecosystem services community of practice
Keune, Hans; Dendoncker, Nicolas; Popa, Florin et al

in Ecosystem Services (2015), 16

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See detailQu’attendent les orthophonistes des applications numériques à destination des personnes avec trouble du spectre autistique ?
Maillart, Christelle ULg; dor, Orianne ULg; Grevesse, Pascale ULg et al

in Rééducation Orthophonique (2015), 264

Numerous technogical applications dedicated to patients affected by the Autistic Spectrum Disorder (ASD) have recently emerged. Research has begun to prove the efficiency of technologies as support tools ... [more ▼]

Numerous technogical applications dedicated to patients affected by the Autistic Spectrum Disorder (ASD) have recently emerged. Research has begun to prove the efficiency of technologies as support tools for therapy for ASD sufferers. However, as far as we know, none study was focused on Speech-Language Therapist’s (SLT) needs. In order to fill this gap, three nominal groups were realized with 19 SLT working with patients with TSA. Identified needs have been ranked in importance. Results stress the importance of open-systems with fully customizable applications allowing the elaboration of individual progress based on specific therapeutic outcomes. [less ▲]

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See detailDosage de la lumière pour maintenir la coexistence d’espèces d’ombre et de demi-ombre dans la régénération de la futaie irrégulière
Ligot, Gauthier ULg; Balandier, Philippe; Courbaud, Benoît et al

in Revue Forestière Française (2015), 3

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See detailSarcopenia as a public health problem
Bruyère, Olivier ULg; Beaudart, Charlotte ULg; Locquet, Médéa ULg et al

in European Geriatric Medicine (2015)

The importance of a health problem is based on its current and expected prevalence, its clinical and economic consequences, the social status of people affected by the problem and the availability of an ... [more ▼]

The importance of a health problem is based on its current and expected prevalence, its clinical and economic consequences, the social status of people affected by the problem and the availability of an effective treatment. In this paper, we review the main current literature on sarcopenia in order to assess whether this geriatric syndrome could be considered as a major public health problem. Our review highlights that based on its prevalence, its clinical consequences, the limitations of the current available treatments as well as on the fact that many frail patients are affected by this geriatric syndrome, sarcopenia should be considered as a health priority by all interested parties in order to reduce its burden. [less ▲]

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See detailLe mystère des loutres d'Arcy-sur-Cure
Rosoux, René; de Bellefroid, Marie des Neiges; Libois, Roland ULg

in Revue scientifique Bourgogne-Nature (2015), 21/22

The discovery of ancient footprints and spraints (faeces) of European Otter in the caves of Arcy-sur-Cure (Yonne), renowned for their great archaeological interest, has led the scientific team of the ... [more ▼]

The discovery of ancient footprints and spraints (faeces) of European Otter in the caves of Arcy-sur-Cure (Yonne), renowned for their great archaeological interest, has led the scientific team of the Museum of Natural Sciences of Orleans to launch an original archaeozoological study. The analyzes allowed, on the one hand, to date the deposits of spraints and, on the other hand, to know the main preys of these “cave otters” after the remains of prey contained in the spraints... This extensive study is among the first of its kind in France, regarding otters who frequently used an underground river a thousand years ago ! [less ▲]

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See detailDominant amphipods of Posidonia oceanica seagrass meadows display considerable trophic diversity
Michel, Loïc ULg; Dauby, Patrick ULg; Gobert, Sylvie ULg et al

in Marine Ecology (2015), 36(4), 969-981

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica ... [more ▼]

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica seagrass meadows and to highlight trophic diversity among this community. Our results indicate that, although all dominant species heavily relied on macroalgal epiphytes, considerable interspecific dietary differences existed. Carbon stable isotope ratios notably showed that some of the amphipod species favored grazing on epiphytes from leaves or litter fragments (Apherusa chiereghinii, Aora spinicornis, Gammarus aequicauda), while others like Dexamine spiniventris preferred epiphytes from rhizomes. The remaining amphipods (Caprella acanthifera, Ampithoe helleri and Gammarella fucicola) readily consumed both groups. In addition, SIAR modeling suggested that most species had a mixed diet, and relied on several food items. Fatty acid analysis and gut contents revealed that contribution of microepiphytic diatoms and of benthic and suspended particulate organic matter to the diet of amphipods were anecdotal. None of the examined species seemed to graze on their seagrass host (low 18:2(n-6) and 18:3(n-3) fatty acids contents), but G. aequicauda partly relied on seagrass leaf detritus, as demonstrated by the lesser 13C-depletion of their tissues. Overall, our findings suggest that amphipods, because of their importance in transfers of organic matter from primary producers and detritus to higher rank consumers, are key-items in P. oceanica associated food webs. [less ▲]

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See detailÉvaluation des compétences informationnelles des étudiants. Brève comparaison des enquêtes EduDOC et FADBEN
Pochet, Bernard ULg; Thirion, Paul ULg

in Mediadoc (2015), (15), 2-8

This article follows the report of a survey assessing information skills of secondary school students in France. It compares the results of this survey with those obtained in Belgium in 2007, with a ... [more ▼]

This article follows the report of a survey assessing information skills of secondary school students in France. It compares the results of this survey with those obtained in Belgium in 2007, with a survey of students in higher education. [less ▲]

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See detail50 ans d'étude de l'industrie : essai de bilan
Merenne-Schoumaker, Bernadette ULg

in Géographies. Bulletin de l'Association de Géographes Français (2015), Décembre 2015

L’objectif de cet article est de tenter de dresser un bilan à travers les travaux que j’ai pu mener sur 50 ans de mutations industrielles en l’articulant, comme dans l’ouvrage de synthèse publié en 2011 ... [more ▼]

L’objectif de cet article est de tenter de dresser un bilan à travers les travaux que j’ai pu mener sur 50 ans de mutations industrielles en l’articulant, comme dans l’ouvrage de synthèse publié en 2011 [« La localisation des industries. Enjeux et dynamiques »], autour de quatre thèmes : le contexte, les activités elles-mêmes, les opérateurs et les localisations. [less ▲]

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See detailA semiótica visual entre princípios gerais e especificidades: a partir do Groupe μ
Dondero, Maria Giulia ULg

in Estudos Semióticos (2015), 11(3), 53-62

Este texto visa a destacar os avanços mais importantes da semiótica visual do Groupe μ,relacionando- os com pesquisas atuais em semiótica pós-greimasiana, sobretudo com a semiótica de Jacques Fontanille ... [more ▼]

Este texto visa a destacar os avanços mais importantes da semiótica visual do Groupe μ,relacionando- os com pesquisas atuais em semiótica pós-greimasiana, sobretudo com a semiótica de Jacques Fontanille sobre a corporeidade (Corps et sens, 2011) e sobre as práticas (Pratiques sémiotiques, 2008). Abordando, por um lado, as tensões entre o caráter geral e transferível dos conceitos de uma linguagem a outra – objetivo de uma retórica geral, para o Groupe μ –, e, por outro, a consideração das especificidades de cada linguagem, exigência que a análise do plano da expressão da imagem torna pertinente em semiótica contemporânea, a pouco lembrada questão da substância da expressão, principalmente em seus desdobramentos texturais, ocupará o centro deste artigo. [less ▲]

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See detailLe raisonnement analogique en pathologie du langage
Krzemien, Magali ULg

in Cahiers de l'ASELF (2015), 12(4), 4-11

Le raisonnement analogique est une habileté humaine qui permet de dresser une correspondance entre deux situations à partir d’une structure relationnelle commune. Il est étroitement lié au langage puisque ... [more ▼]

Le raisonnement analogique est une habileté humaine qui permet de dresser une correspondance entre deux situations à partir d’une structure relationnelle commune. Il est étroitement lié au langage puisque ces deux habiletés s’influencent mutuellement. Ce lien a poussé plusieurs auteurs à s’intéresser aux capacités de raisonnement analogique d’enfants présentant des troubles du langage. Bien que ces enfants aient un niveau intellectuel dans la norme, différentes études montrent qu’ils auraient des difficultés par rapport à leurs pairs de même âge à réaliser des tâches analogiques variées, qu’elles soient verbales ou non. Ces difficultés semblent néanmoins s’estomper lorsque certaines compétences, comme le langage, sont contrôlées. De plus, les enfants dysphasiques semblent davantage dépendants à la similarité perceptuelle présente entre les stimuli, ce qui représente d’importantes implications pour l’acquisition du langage. [less ▲]

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See detailAn overview of potamodromous fish upstream movements in medium-sized rivers, by means of fish passes monitoring
Benitez, Jean-Philippe ULg; Nzau Matondo, Billy ULg; Dierckx, Arnaud ULg et al

in Aquatic Ecology (2015), 49(4), 481-497

This study aims to investigate the upstream movement patterns of potamodromous fish species using multi-annual monitoring of modern multi-species fish passes in two medium-sized Belgian rivers: the ... [more ▼]

This study aims to investigate the upstream movement patterns of potamodromous fish species using multi-annual monitoring of modern multi-species fish passes in two medium-sized Belgian rivers: the Berwinne and the Amble`ve. During a 6-year monitoring period including a frequency of 1–5 times per week, the captured individuals were identified, measured and weighed to determine species abundance, and the periodicity of their seasonal movement patterns was investigated in relation to environmental factors. In the Amble`ve, 22 different fish species were monitored (n = 1513 individuals; biomass of 154 kg) and 14 species in the Berwinne (n = 3720; 408 kg). In both fish passes, inter-annual differences were observed, but the first year of monitoring was the best in terms of biomass, indicating the existence of an opening effect just after the fish passes opening, which allowed new migration routes. Salmonids and rheophilic cyprinids were predominant in terms of biomass, while minnow and spirlin were predominant in terms of number of fishes. The diversity in sizeranged from 46 to 760 mm demonstrating the importance of movements in various life stages. The capture periodicity showed different mobility patterns between the adult and juvenile stages in most species. Movements occurred frequently during the circus reproduction period for some species, but many species moved also apart from spawning period. This study highlights the omnipresence of patrimonial holobiotic potamodromous fish at different life stages that reflect their biological needs to move throughout the annual cycle. They must be considered as target species in river continuity restoration programmes and fish-pass design. [less ▲]

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See detailMethodology manual for European Association for Cardio-Thoracic Surgery (EACTS) clinical guidelines.
Sousa-Uva, Miguel; Head, Stuart J.; Thielmann, Matthias et al

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2015), 48(6), 809-16

The goal of all clinical guidelines is to assist patients and practitioners in making healthcare decisions. However, clinical guidelines have been questioned about their quality, transparency and ... [more ▼]

The goal of all clinical guidelines is to assist patients and practitioners in making healthcare decisions. However, clinical guidelines have been questioned about their quality, transparency and independence. Based on the revision of manuals by other scientific cardiothoracic organizations, this document provides instructions for the development of European Association for Cardio-Thoracic Surgery (EACTS) clinical guidelines and other types of evidence-based documents. Four key areas have been addressed: (i) selection of taskforce members and transparency of relations with the industry, (ii) methods for critical appraisal of medical evidence, (iii) rules for writing recommendations and (iv) review process. It is hoped that, by adopting this methodology, clinical guidelines produced by the EACTS will be well balanced, objective and, importantly, trusted by physicians and patients who benefit from their implementation. [less ▲]

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See detailAssessment of muscle mass, muscle strength and physical performance in clinical practice: An international survey
Bruyère, Olivier ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in European Geriatric Medicine (2015)

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in ... [more ▼]

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in clinical practice. Methods: This study aimed to assess their usage by means of a large online international survey. Since sarcopenia is a specific condition where the assessment of muscle mass, muscle strength and physical performance is important, the survey also assessed the tools used for the diagnosis of this geriatric syndrome. Results: The survey was completed by 255 clinicians from 55 countries across 5 continents. Among these clinicians with geriatrics, rheumatology and endocrinology as major fields of interest, 53.3% assess muscle mass in daily practice, 54.5% muscle strength and 71.4% physical performance. However, the tools used are very different and no single tool is used by all clinicians. The tools and the cut-off values used by clinicians to diagnose sarcopenia are also heterogeneous. Conclusion: Because some tools used for the assessment of muscle mass, muscle strength or physical performance in daily practice are less validated than others, a greater awareness from the clinicians of the importance of using appropriate tools is needed [less ▲]

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See detailSemantic Web and the Future of Health Care Data in Family Practice
Jamoulle, Marc ULg; Vander Stichele, Robert H; Cardillo, Elena et al

in Merit Research Journal of Medicine and Medical Sciences (2015), 3(12), 586-594

Abstract New tools in data management have emerged in the last decade, which are going to revolutionize electronic health records and health information systems. Family practitioners are the first, main ... [more ▼]

Abstract New tools in data management have emerged in the last decade, which are going to revolutionize electronic health records and health information systems. Family practitioners are the first, main and continuous contact with the patient. They are the source and endpoint of the circle of information, generated by judicious medical documentation and smart secondary use of medical data. This article is an introduction to health terminologies, ontologies, semantic data, and linked open data, all expressions used by computer scientists, preparing themselves for the next step: semantic web for health care data [less ▲]

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See detailA probabilistic model for predicting the uncertainties of the humid stiction phenomenon on hard materials
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Journal of Computational & Applied Mathematics (2015), 289

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the ... [more ▼]

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the surfaces roughness and the adhesive force range, the real contact areas are usually smaller than the apparent one, resulting in a scatter in the adhesive forces. Consequently, the stiction is an uncertain phenomenon. In this work, we develop a probabilistic model to predict the uncertainties of stiction due to the capillary forces acting on stiff materials. This model contains two levels: at the deterministic level, the model can predict the pull-out adhesive contact forces for a given surface topology; at the probabilistic level, the model generates independent identically distributed surfaces on which the deterministic solution can be applied to evaluate the uncertainties related to the stiction phenomenon. [less ▲]

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See detailBone marrow processing for hematopoietic stem cell transplantation: recommendations of the SFGM-TC
Rouard, Hélène; Boulanger, Florence; BAUDOUX, Etienne ULg et al

in Hématologie (2015), 21(Supp 3), 42-46

Le prélèvement de moelle osseuse fait l’objet d’un ou de plusieurs traitements préalablement à son injection au receveur. Ces transformations sont basées sur l’évaluation de la compatibilité ... [more ▼]

Le prélèvement de moelle osseuse fait l’objet d’un ou de plusieurs traitements préalablement à son injection au receveur. Ces transformations sont basées sur l’évaluation de la compatibilité érythrocytaire entre le donneur et le receveur, et sur le volume maximal acceptable du greffon. Elles doivent préserver la quantité de cellules mononucléées et de cellules CD34+ injectées ainsi que leur qualité. Une enquête au sein de centres de thérapie cellulaire francophones a révélé une hétérogénéité, d’une part, des pratiques d’ingénierie cellulaire, en partie liée au marché des automates et, d’autre part, des techniques de titrage des anticorps anti-érythrocytaires et de leur absence de normalisation. Dans une démarche qui vise à uniformiser les pratiques d’allogreffe de cellules souches hématopoïétiques (CSH), la Société franc¸aise de greffe de moelle et de thérapie cellulaire (SFGM-TC) a organisé les cinquièmes ateliers d’harmonisation des pratiques en septembre 2014 à Lille. Nous proposons des recommandations concernant la transformation des greffons de moelle osseuse et les critères de libération [less ▲]

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See detailValorisation des produits laitiers dans les ménages peuls du Nord-Est du Bénin
Chabi Toko, Roukayath ULg; Adégbidi, Anselme; Lebailly, Philippe ULg

in International Journal of Biological and Chemical Sciences (2015), 9(6), 2716-2726

La population pastorale et agro-pastorale du Bénin détient presque la totalité du cheptel bovin national. Le lait constitue le produit le plus fréquent issu de l'élevage bovin. Une enquête a été menée ... [more ▼]

La population pastorale et agro-pastorale du Bénin détient presque la totalité du cheptel bovin national. Le lait constitue le produit le plus fréquent issu de l'élevage bovin. Une enquête a été menée dans la commune de Kalalé au sein de 16 ménages peuls afin de comprendre l'organisation de ces ménages dans la gestion du lait. Il ressort que l'organisation autour du capital lait est genre sensible: l'homme aussi bien que la femme, dans leurs rôles respectifs, contribuent à assurer la pérennité du capital bétail. Le lait est géré de façon à privilégier la consommation du ménage et à assurer la reproduction du troupeau. La rémunération du travail fournit ainsi que l'équité dans la distribution des richesses au sein du ménage peul octroi aux femmes qui sont dans le troupeau plus de bénéfices issues du lait provenant du troupeau familial. La disponibilité des produits laitiers dépend de la saison et du milieu. Le lait prévu pour la consommation humaine est gérée de sorte à avoir, une utilisation optimale du lait et de la viande, afin de combler les besoins actuels des membres du ménage, d'assurer la reproduction des biens du ménage ; avant d'alimenter le marché de produits laitiers. [less ▲]

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See detailPRISE EN CHARGE DES TUMEURS EPITHELIALES THYMIQUES
PAULUS, Astrid ULg; SIBILLE, Anne ULg; BOURHABA, Maryam ULg et al

in Revue Médicale de Liège (2015), 70(12), 623-8

Thymic epithelial tumors (TET) are rare. Their optimal care is still poorly defined because of their rarity and of the resulting difficulty to conceive large clinical trials. This review of the literature ... [more ▼]

Thymic epithelial tumors (TET) are rare. Their optimal care is still poorly defined because of their rarity and of the resulting difficulty to conceive large clinical trials. This review of the literature presents the current clinical and therapeutic data on this form of tumors and underlines the need for a multidisciplinary approach to advanced stage TET. Three clinical situations can be encountered: encapsuled tumors lead to radical surgery; tumors associated with capsular invasion justify a postoperative radiotherapy; advanced stages require a multimodal treatment by chemotherapy, possibly completed by surgery and adjuvant radiotherapy. Besides systemic chemotherapies, the place of new therapeutic strategies, such as somatostatin analogues and targeted treatments, requires to be defined. Treatment of late stage TET is based upon a multidisciplinary dialogue, ideally by a reference team. [less ▲]

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See detailDiriger un service d'EAJE : une question centrale pour le développement de sa qualité
Pirard, Florence ULg

in Le Furet - La revue des professionnels de la PETITE ENFANCE (2015), 79

Le rôle central des responsables des services d’éducation et d’accueil des jeunes enfants (EAJE) pour le développement d’une qualité de services est souligné dans de nombreux rapports internationaux ... [more ▼]

Le rôle central des responsables des services d’éducation et d’accueil des jeunes enfants (EAJE) pour le développement d’une qualité de services est souligné dans de nombreux rapports internationaux. Citons notamment les travaux de l’OCDE . Pourtant, selon les contextes, les contours de ce rôle ne sont pas toujours clairement établis ; ils peuvent être source de confusion et d’ambiguïté. La difficulté de gérer les services en conciliant des fonctions sociales, éducatives et économiques est clairement posée. La difficulté également de gérer une équipe dont les membres ont des statuts parfois précaires, des niveaux de formation disparates dans un cadre budgétaire restreint. Dans ce contexte comment relever le défi d’élaborer et de développer une dynamique de projet éducatif concerté dans tous les services qu’ils soient en collectivité ou à domicile, en milieu urbain ou rural ? Ce problème est clairement posé en Belgique francophone où aucune formation spécifique à l’enfance de niveau supérieur n’est organisée, où aucune expérience utile aux fonctions de direction n’est exigée à ce jour. Une recherche en voie de finalisation (juin 2015) visant à mieux définir les compétences nécessaires aux fonctions d’accueil et d’encadrement des services à l’enfance a permis d’associer une série d’acteurs de l’enfance, de l’enseignement, de la formation et de responsables politico-administratifs. Dans une démarche de recherche-action, il s’est agi de se décentrer des réalités de la Belgique francophone pour comprendre comment les questions se posent aussi dans d’autres contextes européens (France, Flandre, Angleterre, Suède) et ensuite, de prendre des décisions relatives à la redéfinition des référentiels métiers et de formation, à la révision des textes réglementaires pour les services. Tout en évitant de donner des directives universelles qui nieraient les spécificités de contexte, l'étude propose de relever une série de questions clés relatives aux fonctions de direction, de points de vigilances à relever ainsi que des idées retenues comme essentielles pour l’avenir. [less ▲]

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See detailTransformed mineral phases during clay ceramic firing
El Ouahabi, Meriam ULg; Daoudi, Lachen; Hatert, Frédéric ULg et al

in Clays and Clay Minerals (2015), 62(6), 470478

Ceramic clays are one of the most complicated ceramic systems because of the very complex relationship between the behavior of minerals during the ceramic processing and the transformations during heating ... [more ▼]

Ceramic clays are one of the most complicated ceramic systems because of the very complex relationship between the behavior of minerals during the ceramic processing and the transformations during heating. A major challenge is to predict the phase transformations in clay ceramics. The aims are to establish reference data of ceramics products that can be formed based on the mineralogical composition of the local raw materials. These data, in turn, can be compared with the archaeological ceramics in order to study their origins. The mineralogical compositions and transformations during the firing (550 to 1100ºC under oxidizing conditions) of seven clayey materials sampled from the main clay deposits of Northern Morocco were evaluated by X-ray powder diffraction. Two groups of clays were evidenced according to the type of neoformed high-temperature minerals: non-calcareous clays and calcareous clays. For the non-calcareous raw materials, spinel is produced at 950°C. Cristobalite and mullite were formed above 1000ºC from clays that contain illite, kaolinite and chlorite. In clays containing vermiculite and high amount of chlorite, hematite was formed from 950°C. Firing of calcareous clays at temperatures > 950ºC yielded Ca-silicates (diopside, gehlenite and wollastonite), spinel, cristobalite, hematite and feldspars. Mullite may also form in the calcareous clay products, when the carbonates content exceeds 10%. [less ▲]

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See detailCe que les émotions font faire aux professionnels du droit: Jalons pour une approche praxéologique des expressions émotionnelles dans la sphère judiciaire
Colemans, Julie ULg

in Social Science Information (2015), 54(4),

L’article propose des pistes de réflexion pour pouvoir saisir la dimension émotionnelle de l’action judiciaire. A partir des acquis de l’ethnométhodologie, il propose d’appréhender les émotions ... [more ▼]

L’article propose des pistes de réflexion pour pouvoir saisir la dimension émotionnelle de l’action judiciaire. A partir des acquis de l’ethnométhodologie, il propose d’appréhender les émotions praxéologiquement, c’est-à-dire comme des accomplissements pratiques afin de décrire la manière dont les expressions émotionnelles sont perçues et interprétées publiquement et en situation. Les émotions apparaissent alors comme des appuis pratiques à la coordination et à la compréhension. [less ▲]

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See detail“Public-based-Learning”: The Place of Publics in Exploring Environmental Controversies for Pedagogical Purposes
Melard, François ULg; Denayer, Dorothée ULg; Semal, Nathalie ULg

in International Journal of Environmental and Science Education (2015), 10(6), 905-920

This article examines a 15 year-old master level seminar dedicated to the exploration of local and complex environmental issues marked by scientific or technological uncertainties. Following a pragmatic ... [more ▼]

This article examines a 15 year-old master level seminar dedicated to the exploration of local and complex environmental issues marked by scientific or technological uncertainties. Following a pragmatic learning approach, we focus our discussion on a triadic relationship between supervisors, students and various concerned publics. A local flood management controversy in Belgium will help to illustrate our approach and point to some learning outcomes. On the basis of this pedagogical experience, we propose to shift from Problem-based-learning towards Public-based-learning that rests on the comparison of the various ways a problem is defined by publics. This comparative approach allows us to deduce a plurality of modes of involvement mobilized in the management of the environmental problems. [less ▲]

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See detailComment établir le pronostic des neuropathies périphériques tronculaires focales ?
WANG, François-Charles ULg

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2015), XIX(10), 334

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