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See detailDROIT ET GÉOGRAPHIE LA QUESTION DE L’(INTER)DÉPENDANCE ÉPISTÉMOLOGIQUE
Paksy, Máté ULg

in Géographie et Cultures (2017), 100

Dans la présente étude, le lecteur va trouver une tentative d’exposer quelques aspects croisés de l’épistémologie juridique et géographique en se focalisant sur deux concepts turbulents du point de vue de ... [more ▼]

Dans la présente étude, le lecteur va trouver une tentative d’exposer quelques aspects croisés de l’épistémologie juridique et géographique en se focalisant sur deux concepts turbulents du point de vue de l’interprétation : celui des territoires prétendument inhabités (terra nullius) et son contraire, celui du processus de déterritorialisation. Selon la conclusion, en dernier ressort, c’est la politique qui doit lier ces deux épistémologies proposant un aspect critique pour la recherche. Les deux concepts – même regardés sous l’angle des épistémologies juridique et géographique – restent incontestablement politiques. D’une part, car la terra nullius met en question la transférabilité de l’idéologie libérale occidentale aux autres cultures. D’autre part, parce que la déterritorialisation n’est pas simplement une technique juridique élaborée contre les revendications des minorités ethniques nationales pour avoir un territoire propre pour leur autonomie territoriale, mais un mouvement plus profond, ciblant les catégories élémentaires épistémiques bien segmentées, pour utiliser la terminologie de Deleuze et Guattari. [less ▲]

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See detailMars Topography Investigated Through the Wavelet Leaders Method: a Multidimensional Study of its Fractal Structure
Deliège, Adrien ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

in Planetary and Space Science (2017), 136C

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based ... [more ▼]

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based on Mars Orbiter Laser Altimeter (MOLA) data using the multifractal formalism called Wavelet Leaders Method (WLM). This approach shows that a scale break occurs at approximately 15 km, giving two scaling regimes in both 1D and 2D cases. At small scales, these topographic profiles mostly display a monofractal behavior while a switch to multifractality is observed in several areas at larger scales. The scaling exponents extracted from this framework tend to be greater at small scales. In the 1D context, these observations are in agreement with previous works and thus suggest that the WLM is well-suited for examining scaling properties of topographic fields. Moreover, the 2D analysis is the first such complete study to our knowledge. It gives both a local and global insight on the scaling regimes of the surface of Mars and allows to exhibit the link between the scaling exponents and several famous features of the Martian topography. These results may be used as a solid basis for further investigations of the scaling laws of the Red planet and show that the WLM could be used to perform systematic analyses of the surface roughness of other celestial bodies. [less ▲]

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See detailThe lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating ERM proteins activation
Sayyed, Sufyan Ali ULg; JOURET, François ULg; Vermeersch, Marjorie et al

in Kidney International (2017)

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body ... [more ▼]

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body homeostasis. Here, using the lipid 5-phosphatase Ship2 global knock-out mice, proximal tubule-specific Ship2 knock-out mice and a proximal tubule cell model where SHIP2 is inactivated, we show that SHIP2 is a negative regulator of microvilli formation, thereby controlling solute reabsorption by the proximal tubule. We found increased PtdIns(4,5)P2 substrate and decreased PtdIns4P product when SHIP2 was inactivated, associated with hyperactivated Ezrin/Radixin/Moesin proteins and increased Rho-GTP. Thus, inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule. This may represent an innovative therapeutic target for renal Fanconi syndromes characterized by decreased reabsorption of solutes by this nephron segment. [less ▲]

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See detailWhat do people ‘learn by looking’ at direct feedback on their energy consumption? Results of a field study in Southern France
Kendel, Adnane; Lazaric, Nathalie; Maréchal, Kevin ULg

in Energy Policy (2017), 108(September 2017), 593605

The abundant literature on consumer feedback shows that it is an efficient instrument for reducing household energy consumption. However, the reported reductions are strongly dependent on contextual ... [more ▼]

The abundant literature on consumer feedback shows that it is an efficient instrument for reducing household energy consumption. However, the reported reductions are strongly dependent on contextual factors and on the type of feedback provided. Given the importance of learning to this respect, this dimension constitutes the core focus of the present study which reports the findings of the TICELEC (i.e. French acronym for information technologies for responsible electricity consumption) project in France. The experiment included a control group (G1: the self-monitoring group) and one equipped group (G2). All participants reduced their consumption and learnt either directly from feedback or indirectly through self-monitoring. The amount of energy savings, which is larger than in similar experiments, can be explained by two factors. First, the specificity of our sample (i.e. high income, high consumption) which allows for potentially large energy savings. Second, high involvement of participants and the building of trust. The quantitative and qualitative dimensions of learning are then discussed. Additionally, we focus on peak-load shifting in G2 with 2 subgroups (G21 and G22). The higher proportion of shifters in G22 and the higher ‘quality’ of their shifting suggest a higher level of learning enabled by the more sophisticated feedback. Although this translated into only a moderately higher rate of energy savings, the higher degree of absorbed knowledge (i.e. through ‘learning by looking through connecting’) might lead to a qualitatively distinctive type of energy saving. [less ▲]

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See detailPhotosynthetic productivity and its efficiencies in ISIMIP2a biome models: benchmarking for impact assessment studies
Ito, Akihiko; Nishina, Kazuya; Reyer, Christopher P. O. et al

in Environmental Research Letters (2017), 12(8), 085001

Simulating vegetation photosynthetic productivity (or gross primary production, GPP) is a critical feature of the biome models used for impact assessments of climate change. We conducted a benchmarking of ... [more ▼]

Simulating vegetation photosynthetic productivity (or gross primary production, GPP) is a critical feature of the biome models used for impact assessments of climate change. We conducted a benchmarking of global GPP simulated by eight biome models participating in the second phase of the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP2a) with four meteorological forcing datasets (30 simulations), using independent GPP estimates and recent satellite data of solar-induced chlorophyll fluorescence as a proxy of GPP. The simulated global terrestrial GPP ranged from 98 to 141 Pg C yr −1 (1981–2000 mean); considerable inter-model and inter-data differences were found. Major features of spatial distribution and seasonal change of GPP were captured by each model, showing good agreement with the benchmarking data. All simulations showed incremental trends of annual GPP, seasonal-cycle amplitude, radiation-use efficiency, and water-use efficiency, mainly caused by the CO 2 fertilization effect. The incremental slopes were higher than those obtained by remote sensing studies, but comparable with those by recent atmospheric observation. Apparent differences were found in the relationship between GPP and incoming solar radiation, for which forcing data differed considerably. The simulated GPP trends co-varied with a vegetation structural parameter, leaf area index, at model-dependent strengths, implying the importance of constraining canopy properties. In terms of extreme events, GPP anomalies associated with a historical El Niño event and large volcanic eruption were not consistently simulated in the model experiments due to deficiencies in both forcing data and parameterized environmental responsiveness. Although the benchmarking demonstrated the overall advancement of contemporary biome models, further refinements are required, for example, for solar radiation data and vegetation canopy schemes. [less ▲]

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See detailDie langen Schatten der Nachkriegszeit. Zur Eupener Bürgermeisterfrage 1964-65
Brüll, Christoph ULg

in GeschichtlichesEupen (2017), LI

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See detailThe global burden of chronic kidney disease: estimates, variability and pitfalls.
Glassock, RJ; Warnock, DG; DELANAYE, Pierre ULg

in Nature Reviews Nephrology (2017), 13(2), 104-114

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See detailThermal comfort and comparison of some parameters coming from hospitals and shopping centers under natural ventilation : The case of Madagascar Island
Nematchoua, Modeste Kameni; Ricciardi, Paola; Reiter, Sigrid ULg et al

in Journal of Building Engineering (2017), 13

Nowadays, in several countries in the tropical islands of the Indian Ocean, including Madagascar island, Comores island, Seychelles island and Mayotte, no adopted and regulated building standards exist ... [more ▼]

Nowadays, in several countries in the tropical islands of the Indian Ocean, including Madagascar island, Comores island, Seychelles island and Mayotte, no adopted and regulated building standards exist. Human health essentially depends on the quality of indoor air, and so several actions should be taken to solve this problem. The purpose of this study is to develop a database of thermal comfort in naturally ventilated buildings inordertoimproveindoorairquality,mainlyinhospitals andshoppingcentersinthelargestislandoftheIndian Ocean.Toachievethisobjective,andduetoalackofdataregardingcomfortinbuiltenvironmentsinthisregion, experimental and subjective studies were carried out in 5 big hospitals and 50 small and large shopping centers, distributed in 25 districts of urban areas in Northern Madagascar. The adaptive approach was used for this purpose. A specific questionnaire based on the ISO7730 and 10551 was designed to collect these data. A total of 400 people participated in this study, and the survey was conducted during rainy and dry seasons. This study discusses the influence of gender, clothing, activities, voters’ mind state and occupants’ control strategies on adaptive comfort assessment. In addition, various comfort parameters were calculated for these buildings. Results show that, in both studied places, the lower and upper acceptable temperatures for 80% of the voters were 23.2 °C and 26.8 °C, while 90% of the customers and patients reported a comfortable temperature range of 24.5–26.2°C. This will help to define proper guidelines to build more comfortable buildings in Madagascar and other countries of the Indian Ocean. [less ▲]

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See detailFamilial history of migraine influences habituation of visual evoked potentials
Lisicki Martinez, Marco ULg; Ruiz-Romagnoli, Emiliano; D'Ostilio, Kevin ULg et al

in Cephalalgia : An International Journal of Headache (2017)

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation ... [more ▼]

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation pattern associated with migraine. The aim of this study was to evaluate the influence of a positive familial history of migraine on VEP amplitude and habituation. Methods: We recorded six blocks of 100 VEP during continuous pattern-reversal stimulation in 30 patients with migraine between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree relative suffering from migraine (HVm) and 15 had not (HV). Results: Both MO and HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 first block amplitudes, compared to HV (habituation slope: MO ¼ 0.033, HVm ¼ 0.021, HV ¼ 0.025, HV vs. MO p ¼ 0.002, HV vs. HVm p ¼ 0.036; mean N1-P1 amplitude in the first block: MO ¼ 9.08 mV, HVm ¼ 9.29 mV, HV ¼ 12.19 mV. HV vs. MO p ¼ 0.041, HV vs. HVm p ¼ 0.076). The first block N1-P1 amplitude was negatively correlated with the habituation slope for both MO (r ¼ .44, p ¼ 0.015) and HVm (r ¼ .56, p ¼ 0.031) while no significant correlation was found in HV (r ¼ .17, p ¼ 0.53). There were no differences in VEP latencies between the groups. Conclusions: Our study suggests that lack of habituation of visual evoked potentials is probably a genetically determined endophenotypic trait that is associated with both migraine and migraine susceptibility. We hypothesize that genetic diversity of populations could account for some of the discrepancies between electrophysiological studies performed in migraine and for interindividual variations among the subgroups. [less ▲]

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See detailDo sex differences in CEOAEs and 2D:4D ratios reflect androgen exposure? A study in women with complete androgen insensitivity syndrome.
van Hemmen, Judy; Cohen-Kettenis, Peggy T.; Steensma, Thomas D. et al

in Biology of sex differences (2017), 8

BACKGROUND: Studies investigating the influence of perinatal hormone exposure on sexually differentiated traits would greatly benefit from biomarkers of these early hormone actions. Click-evoked ... [more ▼]

BACKGROUND: Studies investigating the influence of perinatal hormone exposure on sexually differentiated traits would greatly benefit from biomarkers of these early hormone actions. Click-evoked otoacoustic emissions show sex differences that are thought to reflect differences in early androgen exposure. Women with complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of XY-chromosomes, enabled us to study the effect of complete androgen inaction. The main goal was to investigate a possible link between click-evoked otoacoustic emissions and effective androgen exposure and, thus, whether this can be used as a biomarker. In addition, we aimed to replicate the only previous 2nd vs 4th digit-ratio study in women with CAIS, because despite the widely expressed criticisms of the validity of this measure as a biomarker for prenatal androgen exposure, it still is used for this purpose. METHODS: Click-evoked otoacoustic emissions and digit ratios from women with CAIS were compared to those from control men and women. RESULTS: The typical sex differences in click-evoked otoacoustic emissions and digit ratios were replicated in the control groups. Women with CAIS showed a tendency towards feminine, i.e., larger, click-evoked otoacoustic emission amplitudes in the right ear, and a significant female-typical, i.e., larger, digit ratio in the right hand. Although these results are consistent with androgen-dependent development of male-typical click-evoked otoacoustic emission amplitude and 2nd to 4th digit ratios, the within-group variability of these two measures was not reduced in women with CAIS compared with control women. CONCLUSIONS: In line with previous studies, our findings in CAIS women suggest that additional, non-androgenic, factors mediate male-typical sexual differentiation of digit ratios and click-evoked otoacoustic emissions. Consequently, use of these measures in adults as retrospective markers of early androgen exposure is not recommended. [less ▲]

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See detailComputation of GPS P1–P2 Differential Code Biases with JASON-2
Wautelet, Gilles ULg; Loyer, Sylvain; Mercier, Flavien et al

in GPS Solutions (2017)

GPS Differential Code Biases (DCBs) computation is usually based on ground networks of permanent stations. The drawback of the classical methods is the need for the ionospheric delay so that any error in ... [more ▼]

GPS Differential Code Biases (DCBs) computation is usually based on ground networks of permanent stations. The drawback of the classical methods is the need for the ionospheric delay so that any error in this quantity will map into the solution. Nowadays, many low-orbiting satellites are equipped with GPS receivers which are initially used for precise orbitography. Considering spacecrafts at an altitude above the ionosphere, the ionized contribution comes from the plasmasphere, which is less variable in time and space. Based on GPS data collected onboard JASON-2 spacecraft, we present a methodology which computes in the same adjustment the satellite and receiver DCBs in addition to the plasmaspheric vertical total electron content (VTEC) above the satellite, the average satellite bias being set to zero. Results show that GPS satellite DCB solutions are very close to those of the IGS analysis centers using ground measurements. However, the receiver DCB and VTEC are closely correlated, and their value remains sensitive to the choice of the plasmaspheric parametrization. [less ▲]

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See detailSoil erosion in relation to land use changes in the Amik Lake sediments near the Antioch antique city during the last 4kyr
El Ouahabi, Meriam ULg; Hubert, Aurelia ULg; Lebeau, Héléne et al

in The Holocene (2017)

The Amik Basin in the Eastern Mediterranean region occupied since 6000-7000 BC has sustained a highly variable anthropic pressure culminating during the Late Roman Period when the Antioch city reached its ... [more ▼]

The Amik Basin in the Eastern Mediterranean region occupied since 6000-7000 BC has sustained a highly variable anthropic pressure culminating during the Late Roman Period when the Antioch city reached its golden age. The present 6m long sedimentary record of the Amik Lake occupying the central part of the Basin constrains major paleo-environmental changes over the last 4000 years using a multi-proxy analyses (grain-size, magnetic susceptibility and XRF geochemistry). An age model is provided by combining short-lived radionuclides with radiocarbon dating. A lake/marsh prevailed during the last 4kyrs with a level increase at the beginning of the Roman Period possibly related to optimum climatic condition and water channelling. The Bronze/Iron Ages are characterized by a strong terrigenous input linked to deforestation, exploitation of mineral resources and the beginning of upland cultivation. The Bronze/Iron Age transition marked by the collapse of the Hittite Empire is clearly documented. Erosion continues during the Roman Period and nearly stopped during the Early Islamic Period in conjunction with a decreasing population and soil depletion on the calcareous highland. The soil-stripped limestone outcrops triggered an increase in CaO in the lake water, and a general decrease in ZrO2 released in the landscape that lasts until the present day. During the Islamic Period, pastoralism on the highland sustained continued soil erosion of the ophiolitic Amanus Mountains. The modern Period is characterized by a higher pressure particularly on the Amanus Mountains linked to deforestation, road construction, ore exploitation and the drying of the lake for agriculture practices. [less ▲]

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See detailDetection of a persistent meteoric metal layer in the Martian atmosphere
Crismani, M. M. J.; Schneider, N. M.; Plane, J. M. C. et al

in Nature Geoscience (2017), 10(6), 401-404

Interplanetary dust particles sporadically enter planetary atmospheres at orbital velocities and ablate as collisions occur with ambient gases to produce a persistent layer of metallic atoms (for example ... [more ▼]

Interplanetary dust particles sporadically enter planetary atmospheres at orbital velocities and ablate as collisions occur with ambient gases to produce a persistent layer of metallic atoms (for example, Fe, Mg, Na) in their upper atmospheres. Such layers are well studied at Earth, but have not been directly detected elsewhere in the Solar System. Here we report the detection of a meteoric layer consisting of Mg+ ions near an altitude of 90 km in the Martian atmosphere from ultraviolet remote sensing observations by NASA's MAVEN spacecraft. We observe temporal variability in the Mg+ layer over the course of a Martian year, moving up and down in altitude seasonally and in response to dust storms, and displaying diurnal fluctuations in density. We also find that most meteor showers do not significantly perturb this layer, which constrains the fluence of eleven observed Martian meteor showers to less than our estimated global dust flux. The persistence and variability of the Mg+ layer are difficult to explain with existing models and reconcile with other transient layers of ions observed in the Martian ionosphere. We suggest that the transient layers are not sourced from the persistent Mg+ layer and thus not derived from meteoric material, but are ambient ions produced by some unknown mechanism. © 2017 Macmillan Publishers Limited, part of Springer Nature. [less ▲]

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See detailThe genus Psiadia: Review of traditional uses, phytochemistry and pharmacology.
Mahadeo, Keshika; Grondin, Isabelle; Kodja, Hippolyte et al

in Journal of Ethnopharmacology (2017), 210

ETHNOPHARMACOLOGICAL RELEVANCE: The genus Psiadia Jacq. ex. Willd. belongs to the Asteraceae family and includes more than 60 species. This genus grows in tropical and subtropical regions, being ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: The genus Psiadia Jacq. ex. Willd. belongs to the Asteraceae family and includes more than 60 species. This genus grows in tropical and subtropical regions, being especially well represented in Madagascar and the Mascarene Islands (La Reunion, Mauritius and Rodrigues). Several Psiadia species have been used traditionally for their medicinal properties in Africa and the Mascarene Islands. Based on traditional knowledge, various phytochemical and pharmacological studies have been conducted. However there are no recent papers that provide an overview of the medicinal potential of Psiadia species. Therefore, the aim of this review is to provide a comprehensive summary of the botany, phytochemistry and pharmacology of Psiadia and to highlight the gaps in our knowledge for future research opportunities. MATERIALS AND METHODS: The available information on traditional uses, phytochemistry and biological activities of the genus Psiadia was collected from scientific databases through a search using the keyword 'Psiadia' in 'Google Scholar', 'Pubmed', 'Sciencedirect', 'SpringerLink', 'Web of Science', 'Wiley' and 'Scifinder'. Additionally, published books and unpublished Ph.D. and MSc. dissertations were consulted for botanical information and chemical composition. RESULTS: Historically, species of the genus Psiadia have been used to treat a wide range of ailments including abdominal pains, colds, fevers, bronchitis, asthma, rheumatoid arthritis, skin infections and liver disorders among others. Phytochemical works led to the isolation of flavonoids, phenylpropanoids, coumarins and terpenoids. Furthermore, phytochemical compositions of the essential oils of some species have been evaluated. Crude extracts, essential oils and isolated molecules showed in vitro pharmacological activities, such as antimicrobial, anti-viral, anti-inflammatory, antiplasmodial and antileishmanial activities. Crude extracts of Psiadia dentata and Psiadia arguta have specifically been found to be potentially useful for inhibition of growth of Plasmodium falciparum. However, pharmacological data on this particular genus is quite limited. Further research is necessary to determine the active compounds and the underlying mechanisms. [less ▲]

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See detailDevelopment and performance assessment of a luminex xMAP(R) direct hybridization assay for the detection and identification of indoor air fungal contamination.
Libert, Xavier; Packeu, Ann; Bureau, Fabrice ULg et al

in PLoS ONE (2017), 12(3), 0173390

Considered as a public health problem, indoor fungal contamination is generally monitored using classical protocols based on culturing. However, this culture dependency could influence the ... [more ▼]

Considered as a public health problem, indoor fungal contamination is generally monitored using classical protocols based on culturing. However, this culture dependency could influence the representativeness of the fungal population detected in an analyzed sample as this includes the dead and uncultivable fraction. Moreover, culture-based protocols are often time-consuming. In this context, molecular tools are a powerful alternative, especially those allowing multiplexing. In this study a Luminex xMAP(R) assay was developed for the simultaneous detection of 10 fungal species which are most frequently in indoor air and that may cause health problems. This xMAP(R) assay was found to be sensitive, i.e. its limit of detection is ranging between 0.05 and 0.01 ng of gDNA. The assay was subsequently tested with environmental air samples which were also analyzed with a classical protocol. All the species identified with the classical method were also detected with the xMAP(R) assay, however in a shorter time frame. These results demonstrate that the Luminex xMAP(R) fungal assay developed in this study could contribute to the improvement of public health and specifically to the indoor fungal contamination treatment. [less ▲]

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See detailSartre in Venedig: der Mann, der in die Kälte ging
Cormann, Grégory ULg; Viehöver, Vera ULg

in Bulletin d'Analyse Phénoménologique (2017), 11

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See detailQuand la rue kinoise envahit le politique...
Polet, François ULg

in Cahiers Africains (2017), 94

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See detailLe medicament du mois BIPRESSIL(R) : Premiere association fixe bisoprolol et perindopril arginine.
GACH, Olivier ULg; FALQUE, Bertrand ULg; CANIVET, Antoine ULg et al

in Revue Médicale de Liège (2017), 72(5), 260-265

In patients suffering from systemic arterial hypertension, coronary artery disease, or heart failure, beta-blockers and angiotensin-convertase enzyme inhibitors play a major therapeutic and preventive ... [more ▼]

In patients suffering from systemic arterial hypertension, coronary artery disease, or heart failure, beta-blockers and angiotensin-convertase enzyme inhibitors play a major therapeutic and preventive role. Coronary artery disease remains the leading cause of mortality in industrialized countries. Unless adapted preventive strategy, notably pharmacological interventions, cardiovascular events in these patients remain high. One reason for this relative failure is represented by non-adherence to treatment. A treatment consisting in an association in one pill of several different molecules should confer a higher treatment compliance and thus efficacy. This article describes the characteristics of the first available dual association between a cardioselective beta-blocker agent, bisoprolol, and an angiotensin-convertase enzyme inhibitor, perindopril arginine. [less ▲]

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See detailA scoping review of the public health impact of vitamin D - fortified dairy products for fracture prevention.
Hiligsmann, M; Neuprez, Audrey ULg; Buckinx, Fanny ULg et al

in Archives of Osteoporosis (2017), 12

Purpose : Dairy products are rich in nutrients that positively influence bone health and hence fracture risk, and have therefore been recommended and used for fracture prevention. To help decision makers ... [more ▼]

Purpose : Dairy products are rich in nutrients that positively influence bone health and hence fracture risk, and have therefore been recommended and used for fracture prevention. To help decision makers to efficiently allocate scare resources, it is further important to assess the public health and economic impact of any health intervention. In recent years, several studies have been conducted to estimate the public health and/or economic impact of dairy products but no overview is currently available. This article aims therefore to summarize evidence and review articles that estimated the public health and/or economic impact of vitamin D-fortified dairy products for fracture prevention. Methods: A literature review was conducted using PubMed to identify original studies that assessed the public health and/or economic impact of dairy products (or of calcium/vitamin D supplementation) for fracture prevention up to January 15, 2017. Results: Seven articles were identified. Different stratégies were used by the authors to model the economic/public health impact of dairy products. The four studies assessing the public health impact of dairy products revealed a substantial benefit in terms of fracture prevented, life years, disability-adjusted life years and/or quality-adjusted life years gained. Studies assessing the cost-effectiveness revealed that the use of dairy products is generally cost-effective in the general population aged above 70 years, and from the age of 60 years in populations at high risk of fractures. Conclusion: This systematic review suggests that the use of dairy products could substantially reduce the burden of osteoporotic fractures and seem to be an economically beneficial strategy [less ▲]

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See detailPeur de l'intimité dans la relation amoureuse adolescente : L'implication de l'attachement parental et de l'attachement romantique
Courtain, Audrey ULg; Glowacz, Fabienne ULg

in Annales Médico-Psychologiques (2017), 175(4),

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment ... [more ▼]

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment and the internal working models related to it, while being colored by the emerging romantic attachment and its brand new internal working models. Attachments are deeply shaped by a dynamic interaction whereby the self tries to figure out how to reach security and autonomy still taking the other into account. This considered, intimacy also implies a dynamic feature: on the one hand, closeness and sharing of feelings and/or experiences, and on the other hand, individuality and maintaining of one’s ego. However, just like attachments may be insecure, a fear of intimacy cannot be underestimated during dating. Eventually, bearing in mind the societal and cultural components of attachment and intimacy, gendered explanations cannot be ignored, especially during adolescence. Objectives: Three hypotheses are being tested. First, the continuity from parental to romantic attachment is postulated, meaning that a secure, preoccupied or dismissing attachment to parents might lead to a subsequent secure, preoccupied or dismissing attachment to romantic partners. Second, the influence of parental attachment on the fear of intimacy during teen dating is questioned. The difficult dynamic of closeness/individuality might be explained by the parental attachment’s patterns. Third, the impact of romantic attachment on the fear of intimacy during teen dating is assessed. Also, dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship are studied and put in perspective with the romantic attachment. Materials and methods: The initial sample is made of 283 Belgian students (61% girls) from different teaching systems, aged of 16-22 years old (mean age : 17.43), and 232 of them had already had a dating experience by this time. They were questioned about dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship. Two questionnaires were also self-administered: the Behavioral Systems Questionnaire (assessing attachment) and the Fear of Intimacy Scale. Statistical analyses such as Pearson Chi², Anova and Post-Hoc LSD were carried out. Results: First, we cannot see any continuity between parental and romantic attachment. Second, dismissing attachment to parents fosters the fear on intimacy, compared to secure profiles; this is especially true for dismissing girls. Third, dismissing and preoccupied attachments to romantic partners foster the fear of intimacy, compared to secure profiles; this is especially true for dismissing and even more for preoccupied boys. Also, preoccupied attachment to romantic partners fosters the multiplication of datings, compared to secure; this is especially true for preoccupied and even more for dismissing girls. Finally, there is no effect of romantic attachment on the age of the first dating experience or on the longest lasting relationship. Conclusion: Parental and romantic attachments are involved in the fear of intimacy experienced by adolescents during dating. Still, attachment styles’ influence seems different for girls and boys, and highlights the need to distinguish girls’ from boys’ teen dating experiences. [less ▲]

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See detailMeeting the Needs of Mothers During the Postpartum Period: Using Co-Creation Workshops to Find Technological Solutions.
Slomian, Justine ULg; Emonts, Patrick ULg; Vigneron, Lara ULg et al

in JMIR Research Protocols (2017), 6(5), 76

BACKGROUND: The postnatal period is associated with many new needs for mothers. OBJECTIVE: The aim of this study was to find technological solutions that meet the needs of mothers during the year ... [more ▼]

BACKGROUND: The postnatal period is associated with many new needs for mothers. OBJECTIVE: The aim of this study was to find technological solutions that meet the needs of mothers during the year following childbirth. METHODS: Two co-creation workshops were undertaken with parents and professionals. The aim of the first workshop was to create a list of all the criteria the proposed solution would have to address to meet the needs of mothers after childbirth. The aim of the second workshop was to create solutions in response to the criteria selected during the first workshop. RESULTS: Parents and health professionals want solutions that include empathy (ie, to help fight against the feelings of abnormality and loneliness), that help mothers in daily life, that are personalized and adapted to different situations, that are educational, and that assures some continuity in their contact with health professionals. In practice, we found that parents and professionals think the solution should be accessible to everyone and available at all times. To address these criteria, technology experts proposed different solutions, such as a forum dedicated to the postpartum period that is supervised by professionals, a centralized website, a system of videoconferencing, an online exchange group, a "gift voucher" system, a virtual reality app, or a companion robot. CONCLUSIONS: The human component seems to be very important during the postnatal period. Nevertheless, technology could be a great ally in helping mothers during the postpartum period. Technology can help reliably inform parents and may also give them the right tools to find supportive people. However, these technologies should be tested in clinical trials. [less ▲]

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See detailRIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.
Fettweis, Grégory ULg; Di Valentin, Emmanuel ULg; L'homme, Laurent et al

in Biochimica et Biophysica Acta (2017)

Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and ... [more ▼]

Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and radio-therapy. Photodynamic therapy (PDT) is a treatment well known to induce mainly necrotic and apoptotic cell death in solid tumors. 5-Aminolevulinic acid (5-ALA)-based PDT was recently shown to sensitize human glioblastoma cells (LN-18) to a RIP3 (Receptor Interacting Protein 3)-dependent cell death which is counter-acted by activation of autophagy. These promising results led us to investigate the pathways involved in cell death and survival mechanisms occurring in glioblastoma following PDT. In the present study, we describe a new TSC2 (Tuberous Sclerosis 2)-dependent survival pathway implicating MK2 (MAPKAPK2) kinase and 14-3-3 proteins which conducts to the activation of a pro-survival autophagy. Moreover, we characterized a new RIP3/TSC2 complex where RIP3 is suggested to promote cell death by targeting TSC2-dependent survival pathway. These results highlight (i) a new role of TSC2 to protect glioblastoma against PDT-induced cell death and (ii) TSC2 and 14-3-3 as new RIP3 partners. [less ▲]

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See detailLand use change affects biogenic silica pool distribution in a subtropical soil toposequence
Unzue-Belmonte, Dacil; Ameijeiras-Marino, Yolanda; Opfergelt, Sophie et al

in Solid Earth (2017)

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See detailMolecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525.
Bell, Erica Hlavin; Pugh, Stephanie L.; McElroy, Joseph P. et al

in JAMA Oncology (2017)

Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive ... [more ▼]

Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables. Design, Setting, and Participants: NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiquantitative immunohistochemical validation. Prognostic significance of each protein was examined by single-marker and multimarker Cox regression analyses. To reclassify the prognostic risk groups, significant protein biomarkers on single-marker analysis were incorporated into an RPA model consisting of the same clinical variables (age, Karnofsky Performance Status, extent of resection, and neurologic function) as the existing RTOG RPA. The new RPA model (NRG-GBM-RPA) was confirmed using traditional immunohistochemistry in an independent data set (n = 176). Main Outcomes and Measures: Overall survival (OS). Results: In 452 specimens, MGMT (hazard ratio [HR], 1.81; 95% CI, 1.37-2.39; P < .001), survivin (HR, 1.36; 95% CI, 1.04-1.76; P = .02), c-Met (HR, 1.53; 95% CI, 1.06-2.23; P = .02), pmTOR (HR, 0.76; 95% CI, 0.60-0.97; P = .03), and Ki-67 (HR, 1.40; 95% CI, 1.10-1.78; P = .007) protein levels were found to be significant on single-marker multivariate analysis of OS. To refine the existing RPA, significant protein biomarkers together with clinical variables (age, Karnofsky Performance Status, extent of resection, and neurological function) were incorporated into a new model. Of 166 patients used for the new NRG-GBM-RPA model, 97 (58.4%) were male (mean [SD] age, 55.7 [12.0] years). Higher MGMT protein level was significantly associated with decreased MGMT promoter methylation and vice versa (1425.1 for methylated vs 1828.0 for unmethylated; P < .001). Furthermore, MGMT protein expression (HR, 1.84; 95% CI, 1.38-2.43; P < .001) had greater prognostic value for OS compared with MGMT promoter methylation (HR, 1.77; 95% CI, 1.28-2.44; P < .001). The refined NRG-GBM-RPA consisting of MGMT protein, c-Met protein, and age revealed greater separation of OS prognostic classes compared with the existing clinically based RPA model and MGMT promoter methylation in NRG Oncology RTOG 0525. The prognostic significance of the NRG-GBM-RPA was subsequently confirmed in an independent data set (n = 176). Conclusions and Relevance: This new NRG-GBM-RPA model improves outcome stratification over both the current RTOG RPA model and MGMT promoter methylation, respectively, for patients with GBM treated with radiation and temozolomide and was biologically validated in an independent data set. The revised RPA has the potential to contribute to improving the accurate assessment of prognostic groups in patients with GBM treated with radiation and temozolomide and to influence clinical decision making. Trial Registration: clinicaltrials.gov Identifier: NCT00304031. [less ▲]

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See detailOptical activity of the super-atom molecular orbital (SAMO) states in Li@C60+ conformers
Mignolet, Benoît ULg; Campbell, Eleanor; Remacle, Françoise ULg

in AIP Conference Proceedings (2017), in press

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See detailEffects of parasite and historic driven selection on the diversity and structure of a MHC-II gene in a small mammal species (Peromyscus leucopus) undergoing range expansion
andré, adrien; millien, Virginie; Galan, Maxime et al

in Evolutionary Ecology (2017), DOI 10.1007/s10682-017-9898-z

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See detailMiddle Miocene climate and vegetation models and their validation with proxy data
Henrot, Alexandra-Jane ULg; Utescher, Torsten; Erdei, Boglarka et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

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See detailWhat should a website dedicated to the postnatal period contain? A Delphi survey among parents and professionals
Slomian, Justine ULg; EMONTS, Patrick ULg; Erpicum, Martin ULg et al

in Midwifery (2017), 53

Abstract OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated ... [more ▼]

Abstract OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated that they often or always found that the information that they found on the Internet was incomplete or wrong. Many women therefore believe that health professionals should suggest reliable Internet websites for new mothers. The aim of this study was therefore to find a consensus on the content of a reliable and centralized website dedicated to mothers from the end of pregnancy to 1 year after childbirth. DESIGN: Two rounds of an online Delphi survey were used in this study. SETTING AND PARTICIPANTS: The panel of participants involved in the survey included parents (both mothers and fathers) and professionals (health professionals and professionals of early childhood for mothers of children aged 0 to 2 years). FINDINGS: Ninety-six parents and professionals participated in the first round (37.7 ± 9.76 years; 84.4% of women) and 78 in the second round. The majority of participants (94.6%) thought that a centralized website could help mothers from pregnancy to one year after childbirth. The content that the experts would like to find on a website were themed into five categories: "infants' information", "parents' information", "administrative information", "professionals' information" and "type of resources". In each category, experts highlighted the key words that they found important and should be reported on the website. The most important items highlighted by participants were baby's feeding/breastfeeding (92.8%), babies' needs (84.1%), baby blues (77.9%), postpartum depression (72.1%), management of the couple's relationship (72.1%), women's right to postnatal care (83.6%), links to reliable documents (63.9%) and a list of useful contacts (52.5%). CONCLUSIONS: This study helped to understand the questions that mothers ask themselves during the postpartum period and provided priorities to respond to their questions in the process of developing a website. [less ▲]

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See detailGuided Dive for the Spatial Branch-and-Bound
Gerard, Damien ULg; Koeppe, Matthias; Louveaux, Quentin ULg

in Journal of Global Optimization (2017)

We study the spatial Brand-and-Bound algorithm for the global opti- mization of nonlinear problems. In particular we are interested in a method to find quickly good feasible solutions. Most spatial Branch ... [more ▼]

We study the spatial Brand-and-Bound algorithm for the global opti- mization of nonlinear problems. In particular we are interested in a method to find quickly good feasible solutions. Most spatial Branch-and-Bound-based solvers use a non-global solver at a few nodes to try to find better incumbents. We show that it is possible to improve the branching rules and the node priority by exploiting the solutions from the non-global solver. We also propose several smart adaptive strategies to choose when to run the non-global solver. We show that despite the time spent in solving more NLP problems in the nodes, the new strategies enable the algorithm to find the first good incumbents faster and to prove the global opti- mality faster. Numerous easy, medium size as well as hard NLP instances from the Coconut library are benchmarked. All experiments are run using the open source solver Couenne. [less ▲]

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See detailDiscrimination of three genetically close Aspergillus species by using high resolution melting analysis applied to indoor air as case study.
Libert, Xavier; Packeu, Ann; Bureau, Fabrice ULg et al

in BMC Microbiology (2017), 17(1), 84

BACKGROUND: Indoor air pollution caused by fungal contamination is suspected to have a public health impact. Monitoring of the composition of the indoor airborne fungal contaminants is therefore important ... [more ▼]

BACKGROUND: Indoor air pollution caused by fungal contamination is suspected to have a public health impact. Monitoring of the composition of the indoor airborne fungal contaminants is therefore important. To avoid problems linked to culture-dependent protocols, molecular methods are increasingly being proposed as an alternative. Among these molecular methods, the polymerase chain reaction (PCR) and the real-time PCR are the most frequently used tools for indoor fungal detection. However, even if these tools have demonstrated their appropriate performance, some of them are not able to discriminate between species which are genetically close. A solution to this could be the use of a post-qPCR high resolution melting (HRM) analysis, which would allow the discrimination of these species based on the highly accurate determination of the difference in melting temperature of the obtained amplicon. In this study, we provide a proof-of-concept for this approach, using a dye adapted version of our previously developed qPCR SYBR(R)Green method to detect Aspergillus versicolor in indoor air, an important airborne fungus in terms of occurrence and cause of health problems. Despite the good performance observed for that qPCR method, no discrimination could previously be made between A. versicolor, Aspergillus creber and Aspergillus sydowii. METHODS: In this study, we developed and evaluated an HRM assay for the discrimination between A. versicolor, Aspergillus creber and Aspergillus sydowii. RESULTS: Using HRM analysis, the discrimination of the 3 Aspergillus species could be made. No false positive, nor false negatives were observed during the performance assessment including 20 strains of Aspergillus. The limit of detection was determined for each species i.e., 0.5 pg of gDNA for A. creber and A. sydowii, and 0.1 pg of gDNA for A. versicolor. The HRM analysis was also successfully tested on environmental samples. CONCLUSION: We reported the development of HRM tools for the discrimination of A. versicolor, A. creber and A. sydowii. However, this study could be considered as a study case demonstrating that HRM based on existing qPCR assays, allows a more accurate identification of indoor air contaminants. This contributes to an improved insight in the diversity of indoor airborne fungi and hence, eventually in the causal link with health problems. [less ▲]

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See detailThe closure of arteriovenous fistula in kidney transplant recipients is associated with an acceleration of kidney function decline
WEEKERS, Laurent ULg; VANDERWECKENE, Pauline ULg; pottel, hans et al

in Nephrology Dialysis Transplantation (2017)

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney ... [more ▼]

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney transplant recipients (KTRs) remains unknown. Methods. From 2007 to 2013, we retrospectively categorized 285 KTRs into three groups: no AVF (Group 0, n = 90), closed AVF (Group 1, n = 114) and left-open AVF (Group 2, n = 81). AVF closure occurred at 653 ± 441 days after kidney transplantation (KTx), with a thrombosis:ligation ratio of 19:95. Estimated glomerular filtration rate (eGFR) was determined using the Modification of Diet in Renal Disease equation. Linear mixed models calculated the slope and intercept of eGFR decline versus time, starting at 3 months post-KTx, with a median follow-up of 1807 days (95% confidence interval 1665–2028). Results. The eGFR slope was less in Group 1 (−0.081 mL/min/ month) compared with Group 0 (−0.183 mL/min/month; P = 0.03) or Group 2 (−0.164 mL/min/month; P = 0.09). Still, the eGFR slope significantly deteriorated after (−0.159 mL/min/month) versus before (0.038 mL/min/month) AVF closure (P= 0.03). Study periods before versus after AVF closure were balanced to a mean of 13.5 and 12.5 months, respectively, with at least 10 observations per patient (n = 99). Conclusions. In conclusion, a significant acceleration of eGFR decline is observed over the 12 months following the closure of a functioning AVF in KTRs. [less ▲]

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See detailA novel SMAD3 mutation caused multiple aneurysms in a patient without osteoarthritis symptoms
Courtois, Audrey ULg; Coppieters, Wouter ULg; BOURS, Vincent ULg et al

in European Journal of Medical Genetics (2017)

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See detailCrystallization and Gelation Behavior of Low- and High Melting Waxes in Rice Bran Oil: a Case-Study on Berry Wax and Sunflower Wax
Doan, Chi Diem; Tavernier, Iris; Bin Sintang, Mohd Dona et al

in Food Biophysics (2017), 12

Low-melting berry wax (BEW) has proven to be a good oil gelator with a positive contribution to the consistency and flexibility of the structured oil. Nevertheless, the properties of BEWand the ... [more ▼]

Low-melting berry wax (BEW) has proven to be a good oil gelator with a positive contribution to the consistency and flexibility of the structured oil. Nevertheless, the properties of BEWand the corresponding oleogel have not yet been investigated in-depth. In this research, the difference in crystallization and gelling behavior between sunflower wax (SW), a high melting wax, and BEW, a low-melting wax, in rice bran oil (RBO) was investigated. The difference in melting and crystallization temperatures can be explained by the different chemical composition (long-chain wax esters in SWand shortchain fatty acids in BEW). The heterogeneity in crystal habits (unidirectional platelets versus microcrystalline particles) and polymorphism (orthorhombic versus hexagonal) are responsible for the varying gel strength and hardness of the respective SWand BEW-oleogels. The microcrystalline BEW particles aligned and reorganized during 1-month storage at 5 °C, which leaded to an increase in the gel strength and hardness of BEW-oleogel. The gelling property of SW-oleogel however did not significantly differ after 4 weeks at 5 °C, despite of the appearance of spherulitic crystalline clusters. The changes in the physical properties of wax-based oleogels during storage time were further explored using differential scanning calorimetry, polarized light microscope, powder X-ray diffraction and rheology. [less ▲]

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See detailEvidence of the impact of visuo-spatial processing on magnitude representation in 22q11.2 microdeletion syndrome.
Attout, Lucie ULg; Noël, Marie-Pascale; Vossius, Line ULg et al

in Neuropsychologia (2017), 99

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See detailGuest Editorial : New European Union plant health regime: A more stringent regulation that could impact trade from developing countries in the near future
Schiffers, Bruno ULg

in Tunisian Journal of Plant Protection (2017), 12(1), 3

The new "Plant Health Law" provides more comprehensive and clearer rules for the prevention of entry into, and spread within, the EU territory of pests injurious to plant health but this regulation also ... [more ▼]

The new "Plant Health Law" provides more comprehensive and clearer rules for the prevention of entry into, and spread within, the EU territory of pests injurious to plant health but this regulation also includes regulating pests on the basis of pre-established criteria for risk assesment and prioritising of pests with the most serious consequences. [less ▲]

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See detailLoss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.
Laguesse, Sophie; Close, Pierre ULg; Van Hees, Laura ULg et al

in Frontiers in Cellular Neuroscience (2017), 11

The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective ... [more ▼]

The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective alpha-tubulin acetylation. However, this complex is already expressed by cortical progenitors where it may regulate the early steps of migration by targeting additional proteins. Here we report that connexin-43 (Cx43), which is strongly expressed by cortical progenitors and whose depletion impairs projection neuron migration, requires Elongator expression for its proper acetylation. Indeed, we show that Cx43 acetylation is reduced in the cortex of Elp3cKO embryos, as well as in a neuroblastoma cell line depleted of Elp1 expression, suggesting that Cx43 acetylation requires Elongator in different cellular contexts. Moreover, we show that histones deacetylase 6 (HDAC6) is a deacetylase of Cx43. Finally, we report that acetylation of Cx43 regulates its membrane distribution in apical progenitors of the cerebral cortex. [less ▲]

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See detailAdsorption of terpenic compounds onto organo-palygorskite
Ghrab Sana; Eloussaief, Mabrouk; Lambert, Stéphanie ULg et al

in Environmental Science and Pollution Research (2017)

Essential oils of aromatic plants are currently mentioned as suitable tools for excellent protection of stored grains from insect pest attacks. The present work aimed to study the processes of the ... [more ▼]

Essential oils of aromatic plants are currently mentioned as suitable tools for excellent protection of stored grains from insect pest attacks. The present work aimed to study the processes of the synthesis insecticidal formulation. The active terpenic compounds of essential oil of eucalyptus globulus were fixed in the palygorskite by adsorption process. Two samples types of palygorskites were used; raw and organo-palygorskite. The palygorskite clays were characterized by different physicochemical techniques including X-RAY Diffraction (XRD), Fourier Transformed Infra Red (FTIR) analyses, Thermogravimetric analysis (TG) and differential thermal analysis (DTA), (BET) and Scanning Electron Microscope (SEM). Results reveal that the raw clay has a fibrous structure with impurities essential calcite. These structures and physicochemical properties of raw palygorskite and organo-palygorskite give it the potential of material adsorbent. Results show that the adsorption capacity strongly depends on affinity between terpenic compounds and organic cations rather than on interlayer distance of organo-palygorskite. The highest adsorption capacity of terpenic compounds is acquired with palygorskite interlaced by DDDMA. These results validated the potential utility of the Paly-DDDMA as adsorbents fibrous clay for the retention of terpenic compounds in application of environmental preservation. [less ▲]

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See detailCombination of Partial Least Squares regression and Design of Experiments to model the retention of pharmaceuticals in Supercritical Fluid Chromatography
Andri, Bertyl ULg; Dispas, Amandine ULg; Marini Djang'Eing'A, Roland ULg et al

in Journal of Chromatography. A (2017)

This work presents a first attempt to establish a model of the retention behaviour for pharmaceutical compounds in gradient mode SFC. For this purpose, multivariate statistics were applied on the basis of ... [more ▼]

This work presents a first attempt to establish a model of the retention behaviour for pharmaceutical compounds in gradient mode SFC. For this purpose, multivariate statistics were applied on the basis of data gathered with the Design of Experiment (DoE) methodology. It permitted to build optimally the experiments needed, and served as a basis for providing relevant physicochemical interpretation of the effects observed. Data gathered over a broad experimental domain enabled the establishment of well-fit linear models of the retention of the individual compounds in presence of methanol as co-solvent. These models also allowed the appreciation of the impact of each experimental parameter and their factorial combinations. This approach was carried out with two organic modifiers (i.e. methanol and ethanol) and provided comparable results. Therefore, it demonstrates the feasibility to model retention in gradient mode SFC for individual compounds as a function of the experimental conditions. This approach also permitted to highlight the predominant effect of some parameters (e.g. gradient slope and pressure) on the retention of compounds. Because building of individual models of retention was possible, the next step considered the estab- lishment of a global model of the retention to predict the behaviour of given compounds on the basis of, on the one side, the physicochemical descriptors of the compounds (e.g. Linear Solvation Energy Relationship (LSER) descriptors) and, on the other side, of the experimental conditions. This global model was established by means of partial least squares regression for the selected compounds, in an experimental domain defined by the Design of Experiment (DoE) methodology. Assessment of the model’s predic- tive capabilities revealed satisfactory agreement between predicted and actual retention (i.e. R2 = 0.942, slope = 1.004) of the assessed compounds, which is unprecedented in the field. [less ▲]

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See detailCanagliflozin: A Review in Type 2 Diabetes.
Deeks, Emma D.; Scheen, André ULg

in Drugs (2017)

Canagliflozin (Invokana(R)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D). Canagliflozin lowers ... [more ▼]

Canagliflozin (Invokana(R)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D). Canagliflozin lowers blood glucose levels independently of insulin, with the inhibition of SGLT2 reducing renal reabsorption of glucose and increasing excretion of glucose in the urine. In well-designed clinical trials, canagliflozin (as first-line monotherapy or add-on therapy to other antihyperglycaemic agents) improved glycaemic control in adults with T2D, including those of older age and/or at high cardiovascular (CV) risk, and also had beneficial effects on their bodyweight and blood pressure (BP). CV risk reduction, as well as possible renal benefits, were also seen with canagliflozin in T2D patients at high CV risk in the CANVAS Program, an integrated analysis of two large CV outcomes studies. Canagliflozin was generally well tolerated, had a low risk of hypoglycaemia and was most commonly associated with adverse events such as genital and urinary tract infections and increased urination, consistent with its mechanism of action. Although the amputation and fracture risk observed among recipients of the drug require further investigation, canagliflozin is an important option for T2D management in adults. [less ▲]

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See detailDistributed Training Enhances Implicit Sequence Acquisition in Children With Specific Language Impairment
Desmottes, Lise ULg; Meulemans, Thierry ULg; Patinec, Marie-Aude et al

in Journal of Speech, Language, and Hearing research (2017)

Purpose This study explored the effects of 2 different training structures on the implicit acquisition of a sequence in a serial reaction time (SRT) task in children with and without specific language ... [more ▼]

Purpose This study explored the effects of 2 different training structures on the implicit acquisition of a sequence in a serial reaction time (SRT) task in children with and without specific language impairment (SLI). Method All of the children underwent 3 training sessions, followed by a retention session 2 weeks after the last session. In the massed-training condition, the 3 training sessions were in immediate succession on 1 day, whereas in the distributed-training condition, the 3 training sessions were spread over a 1-week period in an expanding schedule format. Results Statistical analyses showed that the children with normal language were unaffected by the training conditions, performing the SRT task similarly in both training conditions. The children with SLI, however, were affected by the training structure, performing the SRT task better when the training sessions were spaced over time rather than clustered on 1 day. Conclusion This study demonstrated that although intensive training does not increase learning in children with SLI, distributing training sessions over time does increase learning. The implications of these results on the learning abilities of children with SLI are discussed, as are the mechanisms involved in massed versus distributed learning. [less ▲]

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See detailRelationship between low bone mineral density and fractures with incident cardiovascular disease: a systematic review and meta-analysis.
VERONESE, B.; STUBBS, B.; CREPALDI, G. et al

in Journal of Bone and Mineral Research (2017), 32

An increasing evidence base suggests that low bone mineral density (BMD) and fractures are associated with cardiovascular disease (CVD). We conducted a systematic review and meta-analysis summarizing the ... [more ▼]

An increasing evidence base suggests that low bone mineral density (BMD) and fractures are associated with cardiovascular disease (CVD). We conducted a systematic review and meta-analysis summarizing the evidence of low BMD and fractures as risk factors for future CVD. Two independent authors searched major databases from inception to August 1, 2016, for longitudinal studies reporting data on CVD incidence (overall and specific CVD) and BMD status and fractures. The association between low BMD, fractures, and CVD across longitudinal studies was explored by calculating pooled adjusted hazard ratios (HRs) 95% confidence intervals (CIs) with a random-effects meta-analysis. Twenty-eight studies (18 regarding BMD and 10 fractures) followed a total of 1,107,885 participants for a median of 5 years. Taking those with higher BMD as the reference, people with low BMD were at increased risk of developing CVD during follow-up (11 studies; HR¼1.33; 95%CI, 1.27 to 1.38; I2¼53%), after adjusting for a median of eight confounders. This finding was confirmed using a decrease in one standard deviation of baseline BMD (9 studies; HR¼1.16; 95% CI, 1.09 to 1.24; I2¼69%). The presence of fractures at baseline was associated with an increased risk of developing CVD (HR¼1.20; 95% CI, 1.06 to 1.37; I2¼91%). Regarding specific CVDs, low BMD was associated with an increased risk of developing coronary artery disease, cerebrovascular conditions, and CVD-associated death. Fractures at baseline was associated with an increased risk of cerebrovascular conditions and death due to CVD. In conclusion, low BMD and fractures are associated with a small, but significant increased risk of CVD risk and possibly death. © 2017 American Society for Bone and Mineral Research. [less ▲]

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See detailFactors associated with reaching or not reaching target HbA1c after initiation of basal or premixed insulin in patients with type 2 diabetes.
Scheen, André ULg; Schmitt, H.; Jiang, H. H. et al

in Diabètes & Métabolism (2017), 43(69-78),

AIMS: To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as ... [more ▼]

AIMS: To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insulin regimen in patients with type 2 diabetes. METHODS: This post-hoc analysis of insulin-naive patients in the DURABLE study randomised to receive either insulin glargine or insulin lispro mix 25 evaluated the percentages of patients achieving a target HbA1c of <7.0% (<53mmol/mol) per baseline HbA1c quartiles, and the effect of each insulin regimen on the relative contributions of PHG and FHG to overall hyperglycaemia. RESULTS: Patients had comparable demographic characteristics and similar HbA1c and FHG values at baseline in each HbA1c quartile regardless of whether they reached the target HbA1c. The higher the HbA1c quartile, the greater was the decrease in HbA1c, but also the smaller the percentage of patients achieving the target HbA1c. HbA1c and FHG decreased more in patients reaching the target, resulting in significantly lower values at endpoint in all baseline HbA1c quartiles with either insulin treatment. Patients not achieving the target HbA1c had slightly higher insulin doses, but lower total hypoglycaemia rates. CONCLUSION: Smaller decreases in FHG were associated with not reaching the target HbA1c, suggesting a need to increase basal or premixed insulin doses to achieve targeted fasting plasma glucose and improve patient response before introducing more intensive prandial insulin regimens. [less ▲]

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See detailCarbon, Nitrogen and Sulphur isotopic fractionation in captive juvenile hooded seal (Cystophora cristata): application for diet analysis
Pinzone, Marianna ULg; Acquarone, Mario; Huyghebaert, Loreen ULg et al

in Rapid Communications in Mass Spectrometry (2017)

Rationale: Intrinsic biogeochemical markers, such as stable isotope ratios of carbon, nitrogen and sulphur are increasingly used to trace the trophic ecology of marine top predators. However, insufficient ... [more ▼]

Rationale: Intrinsic biogeochemical markers, such as stable isotope ratios of carbon, nitrogen and sulphur are increasingly used to trace the trophic ecology of marine top predators. However, insufficient knowledge of fractionation processes in tissues continues to hamper the use of these markers.Methods: We performed a controlled feeding experiment with eight juvenile hooded seals (Cystophora cristata) that were held on a herring-based diet (Clupea harengus) for two years. Stable isotope ratios were measured via isotope ratio mass spectrometry in three of their tissues and related to values of these markers in their diet. Results: Diet-tissue isotope enrichment (trophic enrichment factor, TEF) values between dietary herring and seal tissues for carbon (Δ13C) were + 0.7 ‰ for red blood cells, + 1.9 ‰ for hair and + 1.1 ‰ for muscle. The TEFs for nitrogen trophic (Δ15N) were + 3.3 ‰ for red blood cells, + 3.6 ‰ for hair and + 4.3 ‰ for muscle. For sulphur, the Δ34S values were +1.1 ‰ for red blood cells, + 1.0 ‰ for hair and + 0.9 ‰ for muscle.Conclusions: These enrichment values were greater than those previously measured in adult seals. This increase may be related to the higher rate of protein synthesis and catabolism in growing animals. This study is the first report on sulphur isotope enrichment values for a marine mammal species. [less ▲]

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See detailLa géographie linguistique au nord du domaine d'oïl
Baiwir, Esther ULg

in Bien Dire et Bien Aprandre : Bulletin du Centre d'Etudes Médiévales et Dialectales de l'Université de Lille III (2017), 32

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See detailJupiter's magnetosphere and aurorae observed by the Juno spacecraft during its first polar orbits
Connerney, J. E. P.; Adriani, A.; Allegrini, F. et al

in Science (2017), 356(6340), 826--832

Jupiter is the largest and most massive planet in our solar system. NASA\textquoterights Juno spacecraft arrived at Jupiter on 4 July 2016 and made its first close pass on 27 August 2016. Bolton et al ... [more ▼]

Jupiter is the largest and most massive planet in our solar system. NASA\textquoterights Juno spacecraft arrived at Jupiter on 4 July 2016 and made its first close pass on 27 August 2016. Bolton et al. present results from Juno\textquoterights flight just above the cloud tops, including images of weather in the polar regions and measurements of the magnetic and gravitational fields. Juno also used microwaves to peer below the visible surface, spotting gas welling up from the deep interior. Connerney et al. measured Jupiter\textquoterights aurorae and plasma environment, both as Juno approached the planet and during its first close orbit.Science, this issue p. 821, p. 826The Juno spacecraft acquired direct observations of the jovian magnetosphere and auroral emissions from a vantage point above the poles. Juno\textquoterights capture orbit spanned the jovian magnetosphere from bow shock to the planet, providing magnetic field, charged particle, and wave phenomena context for Juno\textquoterights passage over the poles and traverse of Jupiter\textquoterights hazardous inner radiation belts. Juno\textquoterights energetic particle and plasma detectors measured electrons precipitating in the polar regions, exciting intense aurorae, observed simultaneously by the ultraviolet and infrared imaging spectrographs. Juno transited beneath the most intense parts of the radiation belts, passed about 4000 kilometers above the cloud tops at closest approach, well inside the jovian rings, and recorded the electrical signatures of high-velocity impacts with small particles as it traversed the equator. [less ▲]

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See detailReconstitution of adaptive immunity after umbilical cord blood transplantation and clinical implication regarding risk of infections
SERVAIS, Sophie ULg; Hannon, Muriel ULg; Peffault de Latour, R. et al

in Stem Cell Invest. (2017), 4

In comparison with allogeneic stem cell transplantation (alloHSCT) with other stem cell sources, umbilical cord blood transplantation (UCBT) was traditionally associated with increased risk of infections ... [more ▼]

In comparison with allogeneic stem cell transplantation (alloHSCT) with other stem cell sources, umbilical cord blood transplantation (UCBT) was traditionally associated with increased risk of infections, particularly during the first 3 months after transplantation. Longitudinal studies of immune monitoring reported peculiar patterns of T- and B-cell recovery in the peripheral blood of UCB recipients during the first months post-transplantation. Overall, current data suggest delayed reconstitution of naive and memory CD4+ and CD8+ T-cell pools after UCBT. This is particularly true for adult recipients and for patients who received in vivo T-cell depleting approaches before the transplantation. Such delayed T-cell recovery may increase susceptibility of UCB recipients for developing opportunistic infections and viral reactivations. Regarding B-cell recovery, UCBT was associated with accelerated B-lymphopoiesis. Recent studies also reported evidence for faster functional memory B-cell recovery in UCB recipients. In this article, we briefly review T- and B-cell reconstitution after alloHSCT, with emphasis on peculiarities observed after UCBT. We further put these data in lines with risks of infections after UCBT. [less ▲]

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See detailComparison of Indium Tin Oxide and Indium Tungsten Oxide as Transparent Conductive Substrates for WO3-Based Electrochromic Devices
Maho, Anthony ULg; Nicolay, Sylvain; Manceriu, Laura ULg et al

in Journal of the Electrochemical Society (2017), 164(2), 25-31

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See detailNew inducible promoter for gene expression and synthetic biology in Yarrowia lipolytica
Trassaert, Marion; Vandermies, Marie ULg; Carly, Frédéric et al

in Microbial Cell Factories (2017), 16(141),

Background The oleaginous yeast Yarrowia lipolytica is increasingly used as alternative cell factory for the production of recombinant proteins. At present, several promoters with different strengths have ... [more ▼]

Background The oleaginous yeast Yarrowia lipolytica is increasingly used as alternative cell factory for the production of recombinant proteins. At present, several promoters with different strengths have been developed based either on the constitutive pTEF promoter or on oleic acid inducible promoters such as pPOX2 and pLIP2. Although these promoters are highly efficient, there is still a lack of versatile inducible promoters for gene expression in Y. lipolytica. Results We have isolated and characterized the promoter of the EYK1 gene coding for an erythrulose kinase. pEYK1 induction was found to be impaired in media supplemented with glucose and glycerol, while the presence of erythritol and erythrulose strongly increased the promoter induction level. Promoter characterization and mutagenesis allowed the identification of the upstream activating sequence UAS1EYK1. New hybrid promoters containing tandem repeats of either UAS1XPR2 or UAS1EYK1 were developed showing higher expression levels than the native pEYK1 promoter. Furthermore, promoter strength was improved in a strain carrying a deletion in the EYK1 gene, allowing thus the utilization of erythritol and erythrulose as free inducer. Conclusions Novel tunable and regulated promoters with applications in the field of heterologous protein production, metabolic engineering, and synthetic biology have been developed, thus filling the gap of the absence of versatile inducible promoter in the yeast Y. lipolytica. [less ▲]

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See detailChanges in The Martian atmosphere induced by auroral precipitation
Shematovich, V.; Bisikalo, D.; Gérard, Jean-Claude ULg et al

in Solar System Research (2017)

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See detailEditorial: Sustainability of rural systems: balancing heritage and innovation
Schmitz, Serge ULg; Dubois, Charline ULg

in Belgeo (2017), 2016(4),

This editorial relates the 24th colloquium of the Commission on the Sustainability of Rural Systems held in Liege and presents the main goals of the Commission. It introduces and discusses briefly the ten ... [more ▼]

This editorial relates the 24th colloquium of the Commission on the Sustainability of Rural Systems held in Liege and presents the main goals of the Commission. It introduces and discusses briefly the ten papers selected for this special issue of Belgeo. [less ▲]

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See detailAb initio study of hydrogenic effective mass impurities in Si nanowires
Peelaers, Hartwin; Durgun, Engin; Partoens, Bart et al

in Journal of Physics : Condensed Matter (2017), 29

The effect of B and P dopants on the band structure of Si nanowires is studied using electronic structure calculations based on density functional theory. At low concentrations a dispersionless band is ... [more ▼]

The effect of B and P dopants on the band structure of Si nanowires is studied using electronic structure calculations based on density functional theory. At low concentrations a dispersionless band is formed, clearly distinguishable from the valence and conduction bands. Although this band is evidently induced by the dopant impurity, it turns out to have purely Si character. These results can be rigorously analyzed in the framework of effective mass theory. In the process we resolve some common misconceptions about the physics of hydrogenic shallow impurities, which can be more clearly elucidated in the case of nanowires than would be possible for bulk Si. We also show the importance of correctly describing the effect of dielectric confinement, which is not included in traditional electronic structure calculations, by comparing the obtained results with those of G0W0 calculations. [less ▲]

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See detailEditorial - De la notion de <<bonne sante>> a des cas pathologiques exemplatifs.
Scheen, André ULg

in Revue Médicale de Liège (2017), 72(7-8), 325-326

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See detailOptimization and validation of a fast Supercritical Fluid Chromatography method for the quantitative determination of vitamin D3 and its related impurities.
Andri, Bertyl ULg; Lebrun, Pierre ULg; Dispas, Amandine ULg et al

in Journal of Chromatography. A (2017)

In the uprising context of green analytical chemistry, Supercritical Fluid Chromatography (SFC) is often suggested as an alternative to Normal Phase Liquid Chromatography. Indeed, SFC provides fast ... [more ▼]

In the uprising context of green analytical chemistry, Supercritical Fluid Chromatography (SFC) is often suggested as an alternative to Normal Phase Liquid Chromatography. Indeed, SFC provides fast, efficient and green separations. In this report, the quantitative performances of SFC were challenged on a real-life case study: the Quality Control (QC) of vitamin D3. A rapid and green SFC method was optimized thanks to the Design of Experiments–Design Space (DoE–DS) methodology. It provided robust and high quality separation of the compounds within a 2 min timeframe, using a gradient of ethanol as co-solvent of the carbon dioxide. The analytical method was fully validated according to the total error approach, demon- strating the compliance of the method to the specifications of U.S. Pharmacopeia (USP: 97.0–103.0%) and European Pharmacopeia (EP: 97.0–102.0%) for an interval of [50–150%] of the target concentration. In order to allow quantification of impurities using vitamin D3 as an external standard in SFC-UV, correction factors were determined and verified during method validation. Thus, accurate quantification of impu- rities was demonstrated at the specified levels (0.1 and 1.0% of the main compound) for a 70.0–130.0% dosing range. This work demonstrates the validity of an SFC method for the QC of vitamin D3 raw material and its application to real samples. Therefore, it supports the switch to a greener and faster separative technique as an alternative to NPLC in the pharmaceutical industry. [less ▲]

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See detailImplementation of multivariable logic functions in parallel by electrical addressing a molecule of three dopants in Silicon
Fresch, B.; Bocquel, J.; Rogge, S. et al

in Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry (2017), 18

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See detailPlasticity and convergence in the evolution of short-necked plesiosaurs
Fischer, Valentin ULg; Benson, Roger B. J.; Zverkov, Nikolai G. et al

in Current Biology (2017), 27

Plesiosaurs were the longest-surviving group of secondarily marine tetrapods, comparable in diversity to today’s cetaceans. During their long evolutionary history, which spanned the Jurassic and the ... [more ▼]

Plesiosaurs were the longest-surviving group of secondarily marine tetrapods, comparable in diversity to today’s cetaceans. During their long evolutionary history, which spanned the Jurassic and the Cretaceous (201 to 66 Ma), plesiosaurs repeatedly evolved long- and short-necked body plans [1,2]. Despite this postcranial plasticity, short-necked plesiosaur clades have traditionally been regarded as being highly constrained to persistent and clearly distinct ecological niches: advanced members of Pliosauridae (ranging from the Middle Jurassic to the early Late Cretaceous) have been characterised as apex predators [2–5], whereas members of the distantly related clade Polycotylidae (middle–Late Cretaceous) were thought to have been fast-swimming piscivores [1,5–7]. We report a new, highly unusual pliosaurid from the Early Cretaceous of Russia that shows close convergence with the cranial structure of polycotylids: Luskhan itilensis gen. et sp. nov. Using novel cladistic and ecomorphological data, we show that pliosaurids iteratively evolved polycotylid-like cranial morphologies from the Early Jurassic until the Early Cretaceous. This underscores the ecological diversity of derived pliosaurids and reveals a more complex evolutionary history than their iconic representation as gigantic apex predators of Mesozoic marine ecosystems suggests. Collectively, these data demonstrate an even higher degree of morphological plasticity and convergence in the evolution of plesiosaurs than previously thought, and suggest the existence of an optimal ecomorphology for short-necked piscivorous plesiosaurs through time and across phylogeny. [less ▲]

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See detailMaternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years.
Robles, M; Gauthier, C; Mendoza García, Luis ULg et al

in PLoS ONE (2017), 12(e0169295),

INTRODUCTION: Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of concentrates is linked to ... [more ▼]

INTRODUCTION: Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of concentrates is linked to alterations of metabolism and the development of osteochondrosis in foals. The aim of this study was to determine if broodmare diet during gestation affects metabolism, osteoarticular status and growth of yearlings overfed from 20 to 24 months of age and/or sexual maturity in prepubertal colts. MATERIAL AND METHODS: Twenty-four saddlebred mares were fed forage only (n = 12, group F) or cracked barley and forage (n = 12, group B) from mid-gestation until foaling. Colts were gelded at 12 months of age. Between 20 and 24 months of age, all yearlings were overfed (+140% of requirements) using an automatic concentrate feeder. Offspring were monitored for growth between 6 and 24 months of age, glucose homeostasis was evaluated via modified frequently sampled intra veinous glucose tolerance test (FSIGT) at 19 and 24 months of age and osteoarticular status was investigated using radiographic examinations at 24 months of age. The structure and function of testicles from prepubertal colts were analyzed using stereology and RT-qPCR. RESULTS: Post-weaning weight growth was not different between groups. Testicular maturation was delayed in F colts compared to B colts at 12 months of age. From 19 months of age, the cannon bone was wider in B vs F yearlings. F yearlings were more insulin resistant at 19 months compared to B yearlings but B yearlings were affected more severely by overnutrition with reduced insulin sensitivity. The osteoarticular status at 24 months of age was not different between groups. CONCLUSION: In conclusion, nutritional management of the pregnant broodmare and the growing foal may affect sexual maturity of colts and the metabolism of foals until 24 months of age. These effects may be deleterious for reproductive and sportive performances in older horses. [less ▲]

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See detailRigid catheters reduced duration of less invasive surfactant therapy procedures in manikins.
RIGO, Vincent ULg; Debauche, Christian; Maton, Pierre et al

in Acta Paediatrica (2017)

Aim: Different catheters can be used for less invasive surfactant therapy (LIST): feeding tubes inserted with or without Magill forceps, different angiocatheters and centre specific devices, such as ... [more ▼]

Aim: Different catheters can be used for less invasive surfactant therapy (LIST): feeding tubes inserted with or without Magill forceps, different angiocatheters and centre specific devices, such as umbilical catheters affixed to a stylet. This study compared the effectiveness of LIST devices and endotracheal tubes (ETT). Methods: Video recordings of 20 neonatologists simulating different LIST techniques on two manikin heads were analysed. Procedural effectiveness was evaluated by the duration of procedures and failure rates. Ease of use was scored. Results: The median procedure time for the Neonatal Intubation Trainer was significantly longer with feeding tubes without Maggil forceps. For the more difficult ALS Baby Trainer, successful procedures lasted a median of 24 (17-32) seconds with ETT, 24 (15-36) seconds with stylet-guided catheters and 34 (27-46) seconds and 37 (29-42) seconds with 13cm and 30cm angiocatheters, respectively. Both methods using feeding tubes were statistically slower than ETT intubation, lasting 32 (25-44) seconds and 39 (27-95) seconds with or without Maggil forceps. Failure rates (7-20%) were no different between the LIST methods. Techniques using feeding tubes were rated as more difficult. Conclusion: Only rigid or stylet-guided catheters required tracheal catheterisation times similar to those of endotracheal intubation and neonatologists found them easier.  KEY NOTES • This manikin study used video recordings of 20 neonatologists to compare the effectiveness of devices for less invasive surfactant therapy (LIST) and endotracheal tubes. • The durations of tracheal catheterisation for LIST using rigid or stylet-guided catheters were no different from those obtained with endotracheal tubes, but feeding tubes with or without Maggil forceps required longer procedures. • Neonatologists found rigid or stylet-guided catheters easier to use. [less ▲]

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See detailIdentification and characterization of EYK1, a key gene for erythritol catabolism in Yarrowia lipolytica
Carly, Frédéric; Gamboa-Melendez, Heber; Vandermies, Marie ULg et al

in Applied Microbiology and Biotechnology (2017), 101

Erythritol is a four-carbon sugar alcohol synthesized by osmophilic yeasts, such as Yarrowia lipolytica, in response to osmotic stress. This metabolite has application as food additive due to its ... [more ▼]

Erythritol is a four-carbon sugar alcohol synthesized by osmophilic yeasts, such as Yarrowia lipolytica, in response to osmotic stress. This metabolite has application as food additive due to its sweetening properties. Although Y. lipolytica can produce erythritol at a high level from glycerol, it is also able to consume it as carbon source. This ability negatively affects erythritol productivity and represents a serious drawback for the development of an efficient erythritol production process. In this study, we have isolated by insertion mutagenesis a Y. lipolytica mutant unable to grow on erythritol. Genomic characterization of the latter highlighted that the mutant phenotype is directly related to the disruption of the YALI0F01606g gene. Several experimental evidences suggested that the identified gene, renamed EYK1, encodes an erythrulose kinase. The mutant strain showed an enhanced capacity to produce erythritol as compared to the wild-type strain. Moreover, in specific experimental conditions, it is also able to convert erythritol to erythrulose, another compound of biotechnological interest. [less ▲]

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See detailModeling pre-metastatic lymphvascular niche in the mouse ear sponge assay.
Garcia-Caballero, Melissa; Van De Velde, Maureen ULg; Blacher, Silvia ULg et al

in Scientific Reports (2017), 7

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental ... [more ▼]

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental for investigating alterations occurring in lymph nodes before tumor cell arrival. In this study, we demonstrate that B16F10 melanoma cell encapsulation in a biomaterial, and implantation in the mouse ear, prevents their rapid lymphatic spread observed when cells are directly injected in the ear. Vascular remodeling in lymph nodes was detected two weeks after sponge implantation, while their colonization by tumor cells occurred two weeks later. In this model, a huge lymphangiogenic response was induced in primary tumors and in pre-metastatic and metastatic lymph nodes. In control lymph nodes, lymphatic vessels were confined to the cortex. In contrast, an enlargement and expansion of lymphatic vessels towards paracortical and medullar areas occurred in pre-metastatic lymph nodes. We designed an original computerized-assisted quantification method to examine the lymphatic vessel structure and the spatial distribution. This new reliable and accurate model is suitable for in vivo studies of lymphangiogenesis, holds promise for unraveling the mechanisms underlying lymphatic metastases and pre-metastatic niche formation in lymph nodes, and will provide new tools for drug testing. [less ▲]

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See detailOf Pins and Beads: Note on a Feminine Costume in Mari
Couturaud, Barbara ULg

in Ash Sharq. Bulletin of the Ancient Near East: Archaeological, Historical And Societal Studies (2017), 1

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See detailCorn stover as feedstock for the production of ethanol: chemical composition of different anatomical fractions and varieties
Berchem, Thomas ULg; Roiseux, Olivier; Vanderghem, Caroline et al

in Biofuels, Bioproducts and Biorefining (2017)

The available grain corn stover produced in Belgium is estimated at 290 000 dry tons, a suffi cient amount to supply a biorefi nery. Differences regarding size, prematurity, and drying speed have been ... [more ▼]

The available grain corn stover produced in Belgium is estimated at 290 000 dry tons, a suffi cient amount to supply a biorefi nery. Differences regarding size, prematurity, and drying speed have been observed among the cultivated grain corn varieties in Wallonia (Belgium). This study aims to evaluate the variation in composition of different anatomical fractions (stalks, leaves, cobs, and husks) of three Walloon varieties of grain corn stover (SyMultitop, Padrino, and Alduna) with significant production volumes. In addition, the Padrino variety was assessed for variation in chemical composition at three harvesting times. Walloon grain corn stover contains large amounts of polysaccharides (33.4% to 41.3% of glucans and 13.9% to 28.2% of xylans) and lignin (10.4% to 15.3%). Some différences were noted between varieties and anatomical fractions. Depending on how the feedstock is harvested, it is possible to produce between 79 and 81 M liters of ethanol per year without adversely affecting soil sustainability. [less ▲]

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See detailNon-renewable and intermittent renewable energy sources: friends and foes?
Jacqmin, Julien ULg; Barranes, Edmond; Poudou, Jean-christophe

in Energy Policy (2017)

This paper studies the links between non-renewable and intermittent renewable energy sources in the production of electricity. Using U.S. state-level data from 1998 to 2015, we find that the relationship ... [more ▼]

This paper studies the links between non-renewable and intermittent renewable energy sources in the production of electricity. Using U.S. state-level data from 1998 to 2015, we find that the relationship between the price of natural gas and investments in solar and wind capacity is non-linear and can be represented by an inverted U-shape. Hence, for relatively low natural gas prices, the two modes of production are substitutes. After a price threshold is reached, the two are complementary. A theoretical explanation argues that this stylized fact is the result of a trade-off between two characteristics of these modes of production: the high degree of flexibility of electricity production using natural gas as an input and the low marginal cost of renewable energy sources. [less ▲]

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See detailANTICANCER, ANTIPLASMODIAL AND ANTITRYPANOSOMAL ACTIVITIES OF CRUDE EXTRACTS OF PLATANUS ORIENTALIS
Ebralidze, L.; Mskhiladze, Lasha; Ledoux, Allison ULg et al

in World Journal of Pharmaceutical Research (2017), 6(3), 170-175

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See detailNew Minerals, Nomenclature and Classification (CNMNC), Newsletter 36. New minerals and nomenclature modifications approved in 2016 and 2017
Halenius, U; Hatert, Frédéric ULg; Pasero, M et al

in European Journal of Mineralogy (2017), 29

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See detailEmbedded solids of any dimension in the X-FEM. Part II - Imposing Dirichlet boundary conditions
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series ... [more ▼]

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. While the first paper is devoted to the design of a dedicated P1 function space to solve elliptic equations defined on manifolds of codimension one or two (curves in 2D and surfaces in 3D, or curves in 3D), the general treatment of Dirichlet boundary conditions, in such a setting, remains to be addressed. This is the aim of this second paper. A new algorithm is introduced to build a stable Lagrange multiplier space from the traces of the shape functions defined on the background mesh. It is general enough to cover: (i) boundary value problems investigated in the first paper (with, for instance, Dirichlet boundary conditions defined along a line in a 3D mismatching mesh); but also (ii) those posed on manifolds of codimension zero (a domain embedded in a mesh of the same dimension) and already considered in Béchet et al. 2009. In both cases, the compatibility between the Lagrange multiplier space and that of the bulk approximation (the dedicated P1 function space used in (i), or classical shape functions used in (ii)) — resulting in the inf–sup condition — is investigate through the numerical Chapelle-Bath test. Numerical validations are performed against analytical and finite element solutions on problems involving 1D or 2D boundaries embedded in a 2D or 3D background mesh. Comparisons with Nitsche’s method and the stable Lagrange multiplier space proposed in Hautefeuille et al. 2012, when they are feasible, highlight good performance of the approach. [less ▲]

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See detailSampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study
Thiry, Justine ULg; Evrard, Brigitte ULg; Nys, Gwenaël ULg et al

in Journal of Chromatography. A (2017), 1479

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to ... [more ▼]

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to collect small quantities (10 or 20 µL) of whole blood, thereby limiting the amount of animals needed. In this study, a quantitative method was developed and subsequently validated for the poorly soluble drug itraconazole (ITZ) using VAMS and ultra-high performance liquid chromatography (UHPLC) coupled to tandem mass spectrometry (MS). A proof of concept study showed that the optimized method is applicable to test the bioavailability of drug formulations containing ITZ. Using VAMS, smaller blood volumes can be taken per sampling point (10-20 µL instead of the conventional 0.2-0.5 mL) avoiding the sacrifice of animals. Moreover, the same rats can be used to compare different drug formulations which strengthens the validity of the results. In long-term bioavailability studies, it is necessary to guarantee the stability of the tested drugs supported on VAMS devices. In this study, we show that ITZ was only stable for 24 hours after collection with VAMS, but for at least two weeks by the storage of extracted samples at -80°C. [less ▲]

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See detailIsotopic niches of Fin Whales from the Mediterranean Sea and the Celtic sea (North Atlantic)
Das, Krishna ULg; Holleville, Ophélie; Ryan, Conor et al

in Marine Environmental Research (2017), 127

The fin whale (Balaenoptera physalus) is the most abundant and widespread mysticete species in the Mediterranean Sea, found mostly over deep, offshore waters of the western and central portion of the ... [more ▼]

The fin whale (Balaenoptera physalus) is the most abundant and widespread mysticete species in the Mediterranean Sea, found mostly over deep, offshore waters of the western and central portion of the region. In the Mediterranean, this species is known to feed mainly on krill, in contrast to its Atlantic counterpart, which displays a more diversified diet. The International Whaling Commission recognizes several managements units in the Atlantic and the Mediterranean Sea and the connectivity between these populations is still being debated. Questions remain about inter-individual feeding strategies and trophic ecology. The goal of this study was to compare isotopic niches of fin whales from the Mediterranean Sea and the Celtic Sea (North Atlantic). δ13C and δ15N values were analysed in 136 skin biopsies from free-ranging Mediterranean fin whales sampled in 2010 and 2011 during campaigns at sea. δ13C and δ15N values ranged from -20.4 to -17.1 ‰ and from 5.9 to 8.9 ‰, respectively. These values are in good agreement with those estimated previously from baleen plates from Mediterranean and North Atlantic fin whales. The narrow isotopic niche width of the Mediterranean fin whale (Standard Ellipses area SEAc) compared to the North Atlantic fin whale raises many concerns in the context of global changes and long-term consequences. One could indeed expect that species displaying narrow niches would be more susceptible to ecosystem fragmentation and other anthropogenic impacts. [less ▲]

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See detailUnraveling microbial ecology of industrial-scale Kombucha fermentations by metabarcoding and culture-based methods.
Coton, Monika; Pawtowski, Audrey; Taminiau, Bernard ULg et al

in FEMS Microbiology Ecology (2017), 93(5),

Kombucha, historically an Asian tea-based fermented drink, has recently become trendy in Western countries. Producers claim it bears health-enhancing properties that may come from the tea or metabolites ... [more ▼]

Kombucha, historically an Asian tea-based fermented drink, has recently become trendy in Western countries. Producers claim it bears health-enhancing properties that may come from the tea or metabolites produced by its microbiome. Despite its long history of production, microbial richness and dynamics have not been fully unraveled, especially at an industrial scale. Moreover, the impact of tea type (green or black) on microbial ecology was not studied. Here, we compared microbial communities from industrial-scale black and green tea fermentations, still traditionally carried out by a microbial biofilm, using culture-dependent and metabarcoding approaches. Dominant bacterial species belonged to Acetobacteraceae and to a lesser extent Lactobacteriaceae, while the main identified yeasts corresponded to Dekkera, Hanseniaspora and Zygosaccharomyces during all fermentations. Species richness decreased over the 8-day fermentation. Among acetic acid bacteria, Gluconacetobacter europaeus, Gluconobacter oxydans, G. saccharivorans and Acetobacter peroxydans emerged as dominant species. The main lactic acid bacteria, Oenococcus oeni, was strongly associated with green tea fermentations. Tea type did not influence yeast community, with Dekkera bruxellensis, D. anomala, Zygosaccharomyces bailii and Hanseniaspora valbyensis as most dominant. This study unraveled a distinctive core microbial community which is essential for fermentation control and could lead to Kombucha quality standardization. [less ▲]

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See detailAn Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters
Delcourt, Cécile ULg; Gremler, Dwayne; De Zanet, Fabrice ULg et al

in Journal of Service Management (2017), 28(1), 85-106

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them ... [more ▼]

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the criticality of the encounter. Drawing on cognitive appraisal theory, this study proposes that two key competencies—employee emotional competence (EEC) and employee technical competence (ETC)—affect negative customer emotions and customer satisfaction with employee response in ECSEs. Design/methodology—This study relies on a video-based experiment that depicts a customer involved in an ECSE as a service provider delivers bad news to him. The hypothesis tests use a two-way independent analysis of covariance. Results—Both emotional and technical competencies must be displayed to improve the customer experience in an ECSE. When EEC is low, ETC does not decrease negative customer emotions or increase customer satisfaction with employee response. When EEC is high, ETC instead has a significant impact on both customer outcomes. Practical implications—Managers must train employees to develop both technical and emotional competencies. Employees who demonstrate only one type cannot temper customers’ emotions or enhance their perceptions of the employees’ response as well as can those strong in both competencies. Originality/value—Using a video-based experiment, this study examines the moderating role of EEC in the relationship between ETC and two key aspects of the customer experience in an ECSE (negative customer emotions and customer satisfaction with employee responses) following the delivery of bad news. [less ▲]

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Cartilage (2017)

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no ... [more ▼]

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA. [less ▲]

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See detailLEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Elayyan, Jinan; Lee, Eun-Jin; Gabay, Odile et al

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017)

Reduced SIRT1 activity and levels during osteoarthritis (OA), promotes gradual loss of cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase (MMP) 13, partially ... [more ▼]

Reduced SIRT1 activity and levels during osteoarthritis (OA), promotes gradual loss of cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase (MMP) 13, partially because of enhanced LEF1 transcriptional activity. In this study, we assessed the role of SIRT1 in LEF1-mediated MMP13 gene expression in human OA chondrocytes. Results showed that MMP13 protein levels and enzymatic activity decreased significantly during SIRT1 overexpression or activation by resveratrol. Conversely, MMP13 gene expression was reduced in chondrocytes transfected with SIRT1 siRNA or treated with nicotinamide (NAM), a sirtuin inhibitor. Chondrocytes challenged with IL-1beta, a cytokine involved in OA pathogenesis, enhanced LEF1 protein levels, and gene expression, resulting in increased MMP13 gene expression; however, overexpression of SIRT1 during IL-1beta challenge impeded LEF1 levels and MMP13 gene expression. Previous reports showed that LEF1 binds to the MMP13 promoter and transactivates its expression, but we observed that SIRT1 repressed LEF1 protein and mRNA expression, ultimately reducing LEF1 transcriptional activity, as judged by luciferase assay. Finally, mouse articular cartilage from Sirt1-/- presented increased LEF1 and MMP13 protein levels, similar to human OA cartilage. Thus, demonstrating for the first time that SIRT1 represses MMP13 in human OA chondrocytes, which appears to be mediated, at least in part, through repression of the transcription factor LEF1, a known modulator of MMP13 gene expression.-Elayyan, J. Lee, E.-J., Gabay, O., Smith, C. A., Qiq, O., Reich, E., Mobasheri, A., Henrotin, Y., Kimber, S. J., Dvir-Ginzberg, M. LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. [less ▲]

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See detailABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.
Canaani, Jonathan; Savani, Bipin N.; Labopin, Myriam et al

in American Journal of Hematology (2017)

ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an ... [more ▼]

ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibility affects outcome in MMURD transplantation for acute myeloid leukemia (AML) patients is unknown. We evaluated 1,013 AML patients who underwent MMURD transplantation between 2005 and 2014. Engraftment rates were comparable between ABO matched and mismatched patients, as were relapse incidence [34%; 95% confidence interval (CI), 28-39; for ABO matched vs. 36%; 95% CI, 32-40; for ABO mismatched; P = .32], and nonrelapse mortality (28%; 95% CI, 23-33; for ABO matched vs. 25%; 95% CI, 21-29; for ABO mismatched; P = .2). Three year survival was 40% for ABO matched and 43% for ABO mismatched patients (P = .35), Leukemia free survival rates were also comparable between groups (37%; 95% CI, 32-43; for ABO matched vs. 38%; 95% CI, 33-42; for ABO mismatched; P = .87). Incidence of grade II-IV acute graft versus host disease was marginally lower in patients with major ABO mismatching (Hazard ratio of 0.7, 95% CI, 0.5-1; P = .049]. ABO incompatibility probably has no significant clinical implications in MMURD transplantation. [less ▲]

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See detailFrom tracks to fine-scale movement modes:a straightforward approach for identifying multiple spatial movement patterns
Morelle, Kévin; Bunnefeld, Nils; Lejeune, Philippe ULg et al

in Methods in Ecology and Evolution (2017)

1. Thanks to developments in animal tracking technology, detailed data on the movement tracks of individual animals are now attainable for many species. However, straightforward methods to decompose ... [more ▼]

1. Thanks to developments in animal tracking technology, detailed data on the movement tracks of individual animals are now attainable for many species. However, straightforward methods to decompose individual tracks into high-resolution, spatial modes are lacking but are essential to understand what an animal is doing. 2. We developed an analytical approach that combines separately validated methods into a straightforward tool for converting animal GPS tracks into short-range movement modes. Our three-step analytical process comprises: (i) decomposing data into separate movement segments using behavioural change point analysis; (ii) defining candidate movement modes and translating them into nonlinear or linear equations between net squared displacement (NSD) and time and (iii) fitting each candidate equation to NSD segments and determining the best-fitting modes using Concordance Criteria, Akaike's Information Criteria and other fine-scale segment characteristics. We illustrate our approach for three sub-adults, male wild boar Sus scrofa tracked at 15-min intervals over 4 months using GPS collars. We defined five candidate movement modes based on previously published studies of short-term movements: encamped, ranging, round trips (complete and partial) and wandering. 3. Our approach successfully classified over 80% of the tracks into these movement modes lasting between 5 and 54 h and covering between 300 m to 20 km. Repeated analyses of GPS data resampled at different rates indicated that one positional fix every 3–4 h was sufficient for >70% classification success. Classified modes were consistent with published observations of wild boar movement, further validating our method. 4. The proposed approach advances the status quo by permitting classification into multiple movement modes (where these are adequately discernable from spatial fixes) facilitating analyses at high temporal and spatial resolutions, and is straightforward, largely objective, and without restrictive assumptions, necessary parameterizations or visual interpretation. Thus, it should capture the complexity and variability of tracked animal movement mode for a variety of taxa across a wide range of spatial and temporal scales. [less ▲]

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See detailEmployee perspectives on safety citizenship behaviors and safety violations
Chmiel, Nik; Laurent, Julie ULg; Hansez, Isabelle ULg

in Safety Science (2017), 93

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two ... [more ▼]

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two types of safety violation: routine violations conceptualized as related to an individual’s available cognitive energy or ‘effort’; and situational violations, which are those provoked by the organization (Reason, 1990). Study 1 showed SCRDs predicted situational violations only, and partially mediated the relationships between Perceived Management Commitment to Safety (PMCS) and work engagement with situational violations. These findings add to those by Hansez and Chmiel (2010), showing that routine and situational violations have predictors that differ. Study 1 findings also extend research reported by Turner et al. (2005), by showing that the effect of Job Control on SCRDs was mediated by both PMCS and work engagement. In study 2, participation in discretionary safety activities (safety participation) mediated the relationship between SCRDs and situational violations. Similar to study 1 The link between SCRDs and routine violations was non-significant and, strikingly, so was the link between safety participation and routine violations. These results support the view that processes involving SCRDs and safety participation are not cognitive-energetical in nature. In addition, study 2 findings extend previous work by Neal and Griffin (2006) by showing that SCRDs and safety knowledge partially mediated relationships between safety motivation and safety participation, whereas the direct effect of safety motivation on safety participation was non-significant. The results from both studies support the view that SCRDs are important in predicting situational violations. In study 2 SCRDs were shown to partially mediate the relationship between safety motivation and selfreported participation in discretionary safety activities (Safety Participation) which, in turn, related to situational violations. Interestingly there was no significant direct link between SCRDs and situational violations. These findings support the view that the effect of SCRDs on situational violations is fully mediated by participation in discretionary safety activities. [less ▲]

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See detailCaryl Phillips’s The Lost Child: A Story of Loss and Connection
Ledent, Bénédicte ULg; O'Callaghan, Evelyn

in Ariel : A Review of International English Literature (2017), 48(3&4), 229-247

Through a reading of Caryl Phillips’ most recent novel, The Lost Child (2015), this article examines a paradox at the heart of Phillips’ work: the tension between the ruptures and continuities brought ... [more ▼]

Through a reading of Caryl Phillips’ most recent novel, The Lost Child (2015), this article examines a paradox at the heart of Phillips’ work: the tension between the ruptures and continuities brought about by the historical encounter of north and south (specifically, eighteenth-century northern Britain and the Caribbean). The novel focuses on the lot of the lost children who were born in the wake of such a fateful meeting and whose narratives are often missing from the literary and historical records even as their ghostly traces haunt today’s British society and indeed the British literary canon. Yet, as this essay demonstrates, the family disruptions and sense of loss, a legacy of slavery that mars the lives of the characters, are compensated at the fictional level by a form of literary parenthood. The novel relies on a fruitful intertextual conversation with other novels that, like The Lost Child, invest in the narrative reclamation of absent stories, the unvoiced accounts of orphans and lost, stolen, or denied children of the Empire. These texts include Emily Brontë’s Wuthering Heights (1847) as well as Jean Rhys’ Wide Sargasso Sea (1966) and some of Phillips’ earlier works, notably Cambridge (1991). [less ▲]

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See detailVolumetric absorptive microsampling: Current advances and applications.
Kok, Miranda ULg; Fillet, Marianne ULg

in Journal of Pharmaceutical & Biomedical Analysis (2017)

Recently, volumetric absorptive microsampling (VAMS) has been introduced for the sampling of biological fluids, and more particularly whole blood, on a porous hydrophilic tip. VAMS enables the collection ... [more ▼]

Recently, volumetric absorptive microsampling (VAMS) has been introduced for the sampling of biological fluids, and more particularly whole blood, on a porous hydrophilic tip. VAMS enables the collection of small, accurate and precise blood volumes (10 or 20muL) regardless of the hematocrit. After drying, the samples can be stored or directly analyzed. The stability of various compounds in dried samples supported on VAMS tips varies from one day to a few months at room temperature, and increases at lower temperatures. The complete tip is used during a simple and straightforward sample preparation. Compounds can be extracted with a variety of solvents, and thereafter directly analyzed. A design of experiments is recommended to determine the optimal extraction conditions for a reproducible recovery. The recovery of compounds might be influenced by the hematocrit. In the last two years, various pharmacokinetic and therapeutic drug monitoring studies have been conducted with VAMS. This review covers the general aspects related with the use of VAMS and its applicability is demonstrated through examples. [less ▲]

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See detailA Quantitative Doignon-Bell-Scarf theorem
Aliev, Iskander; Bassett, Robert; De Loera, Jesus et al

in Combinatorica (2017)

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative ... [more ▼]

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative generalization: Given an integer k, we prove that there exists a constant c(n,k), depending only on the dimension n and on the number k, such that if a bounded polyhedron {x in R^n : Ax <= b} contains exactly k integer points, then there exists a subset of the rows, of cardinality no more than c(n,k), defining a polyhedron that contains exactly the same k integer points. In this case c(n,0)=2^n as in the original case of Doignon-Bell-Scarf for infeasible systems of inequalities. We work on both upper and lower bounds for the constant c(n,k) and discuss some consequences, including a Clarkson-style algorithm to find the l-th best solution of an integer program with respect to the ordering induced by the objective function. [less ▲]

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See detailComparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species
Kapepula, Paulin Mutwale; Kabamba Ngombe, Nadege; Tshisekedi Tshibangu, Pascal et al

in Natural Product Research (2017), 6419(March), 1--8

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See detailMolecular dynamics study of micelle proeprties according to their size
Lebecque, Simon ULg; Crowet, Jean-Marc ULg; Nasir, Mehmet Nail ULg et al

in Journal of Molecular Graphics and Modelling (2017), 72

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have ... [more ▼]

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have notably several applications in many domains, such as drug delivery or membrane protein solubilization. In this context, the study of micelle formation in relation with the structural and physico-chemical properties of surfactants is of great interest to better control their use in the different application fields. In this work, we use the MD approach developed by Yoshii et al. and extend it to surfactants with different structures. We aim to systematically investigate different micellar properties as a function of the aggregates size by a molecular dynamics approach, to get an insight into the micellar organization and to collect some relevant descriptors about micelle formation. For this, we perform short MD simulations of preformed micelles of various sizes and analyze three parameters for each micelle size, namely the eccentricity of the micelles, the hydrophobic/hydrophilic surface ratio and the hydrophobic tails hydration. If these parameters are known descriptors of micelles, they were not yet studied in this way by MD. We show that eccentricity, used as “validator” parameter, exhibits minimal values when the aggregate size is close to the experimental aggregation number for surfactants that are known to form spherical micelles. This hence indicates that our methodology gives consistent results. The evolution of the two descriptors follows another scheme, with a sharp increase and decrease, respectively, followed by a leveling-off. The aggregate sizes at which this stabilization starts to occur are close to the respective aggregation number of each surfactant. In our approach, we validate the use of these descriptors to follow micelle formation by MD, from “simple” surfactants to more complex structures, like lipopeptides. Our calculations also suggest that some peculiar behavior, like that of TPC, can be highlighted by our approach. In the context of peptidic surfactants, our methodology could further help to improve computer simulations combined to molecular thermodynamic models to predict micellar properties of those more complex amphiphilic molecules. [less ▲]

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See detailPercevoir et reconnaître des symboles : La théorie de la représentation iconique de Dominic Lopes
Hagelstein, Maud ULg

in Bulletin d'Analyse Phénoménologique (2017)

In his works on the epistemological value of images (Understanding Pictures — 1996), Dominic Lopes (Department of Philosophy — University of British Columbia) develops an analytical aesthetics primarily ... [more ▼]

In his works on the epistemological value of images (Understanding Pictures — 1996), Dominic Lopes (Department of Philosophy — University of British Columbia) develops an analytical aesthetics primarily concerned with iconic representation. His analysis distinguishes two models of iconic representation comprehension. In the first model, inspired by perceptual approaches like that of Richard Wollheim, the process of image recognition is rooted in perception (to sum it up: perceptualism embraces the idea of « likeness » between the image and what it represents). One of this model’s shortcomings, however, is that it too readily assumes that perception can be a natural, straightforward process. Indeed, iconic representation can not be understood through perception alone, as vision is of course influenced by cultural and, most of all, cognitive processes. A representative model thus needs to account for the ways in which iconic recognition differs from ordinary visual recognition. In the second model, which build off of symbolic approaches like that of Nelson Goodman, iconic representation works the same way as other types of symbols, particularly linguistic ones. Thus, this approach considers the similarities between images and language (representations which are both affected by processes of denotation and predication). However, we all know how strongly image theoreticians have been resisting the linguistic paradigm (iconic turn topic): some worry about overlooking the image’s semantic density in favor of its « simple » descriptive quality. Lopes finds a path between these two models by developing a « theory of aspect recognition », which incorporates perceptive elements into a symbolic structure. According to Lopes, if we agree that images belong to symbolic systems of denotation, then « they might be symbols for which the reference is dependent on the carrying out of perceptive aptitudes », a claim which my talk will explore. I will also discuss how Lopes’ theory accounts for skills acquisition (the capacity to recognize) through images, and shows how images help these skills progressively develop. [less ▲]

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See detailImplementation of probabilistic algorithms by multi-chromophoric molecular networks with application to multiple travelling pathways
Fresch, B.; Remacle, Françoise ULg; Levine, R. D.

in Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry (2017), 18

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See detailIntegration of Gene Expression and Methylation to unravel Biological Networks in Glioblastoma Patients
Bessonov, Kyrylo ULg; Gadaleta, Francesco; Van Steen, Kristel ULg

in Genetic Epidemiology (2017)

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information ... [more ▼]

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information. In this work we describe Regression2Net, a computational approach that is able to integrate gene expression and genomic or methylome data in two steps. First, penalized regressions are used to build Expression-Expression (EEnet) and Expression-Genome or –Methylome (EMnet) networks. Second, network theory is used to highlight important communities of genes. When applying our approach Regression2Net to gene expression and methylation profiles for individuals with glioblastoma multiforme, we identified respectively 284 and 447 potentially interesting genes in relation to glioblastoma pathology. These genes showed at least one connection in the integrated networks ANDnet and XORnet derived from aforementioned EEnet and EMnet networks. Whereas the edges in ANDnet occur in both EEnet and EMnet, the edges in XORnet occur in EMnet but not in EEnet. In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response and several cancer types. Importantly, we observed significant over-representation of cancer related pathways including glioma, especially in the XORnet network, suggesting a non-ignorable role of methylation in glioblastoma multiforma. In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. [less ▲]

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See detailSpecies delimitation in the recalcitrant moss genus Rhynchostegiella (Brachytheciaceae)
Patiño, J.; Hedenäs, L.; Dirkse, G. et al

in Taxon (2017), 66

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See detailThe right dorsal premotor mosaic: organization, functions, and connectivity
Genon, Sarah ULg; Li, Hai; Fan, Lingzhong et al

in Cerebral Cortex (2017), 27(3), 2095-2110

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a ... [more ▼]

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our CBP results to parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography,. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into five distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found (i) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory (ii) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and (iii) a caudal subregion closely integrated with the motor system. Additionally, we found (iv) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and (v) a ventral subregion, whose functional profile fits the concept of an eye-movement related field. In conclusion, right PMd may be considered as a functional mosaic formed by five subregions. [less ▲]

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See detail"Sarebbe riuscita insieme un’opera molto onorata" : per Perino del Vaga a Pisa.
Geremicca, Antonio ULg

in Studi di Storia dell'arte (2017)

There are still many questions concerning Perino del Vaga’s career in the early 1530s, especially in regard of his crucial decision to leave Genoa for a new destination. Before going back to Rome and ... [more ▼]

There are still many questions concerning Perino del Vaga’s career in the early 1530s, especially in regard of his crucial decision to leave Genoa for a new destination. Before going back to Rome and becoming the Farnese court's main painter (1537-1538), Perino evaluated the opportunity to live in Tuscany, where he also bought a house (1534). The aim of this article is to rebuild the activity of the artist in Pisa that apparently has been more intense than previously thought by studies. Perino stayed in the city at least in three different occasions, between 1531 and 1537, to participate at the new decoration of the Cathedral, that unfortunately was left incomplete and almost nothing remained nowadays. In addition to this, Vasari wrote a contradictory description of it in the Lives (1568). The article will focus on Perino’s graphic production during that period that might suggest how he was preparing his projects for the Cathedral. [less ▲]

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See detailCounting the number of non-zero coefficients in rows of generalized Pascal triangles
Leroy, Julien ULg; Rigo, Michel ULg; Stipulanti, Manon ULg

in Discrete Mathematics (2017), 340

This paper is about counting the number of distinct (scattered) subwords occurring in a given word. More precisely, we consider the generalization of the Pascal triangle to binomial coefficients of words ... [more ▼]

This paper is about counting the number of distinct (scattered) subwords occurring in a given word. More precisely, we consider the generalization of the Pascal triangle to binomial coefficients of words and the sequence (S(n))n≥0 counting the number of positive entries on each row. By introducing a convenient tree structure, we provide a recurrence relation for (S(n))n≥0. This leads to a connection with the 2-regular Stern–Brocot sequence and the sequence of denominators occurring in the Farey tree. Then we extend our construction to the Zeckendorf numeration system based on the Fibonacci sequence. Again our tree structure permits us to obtain recurrence relations for and the F-regularity of the corresponding sequence. [less ▲]

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See detailAppropriateness criteria for the use of cardiovascular imaging in heart valve disease in adults: a European Association of Cardiovascular Imaging report of literature review and current practice
Chambers, JB; Garbi, M; Nieman, K et al

in European Heart Journal - Cardiovascular Imaging (2017)

Heart valve disease is common and a major indication for imaging. Echocardiography is the first-line imaging technique for diagnosis, assessment, and serial surveillance. However, other modalities ... [more ▼]

Heart valve disease is common and a major indication for imaging. Echocardiography is the first-line imaging technique for diagnosis, assessment, and serial surveillance. However, other modalities, notably cardiac magnetic resonance imaging and computerized tomography, are used if echocardiographic imaging is suboptimal or to obtain complementary information, particularly to aid risk assessment in individual patients. This review is a summary of current evidence for state-of-the-art clinical practice to inform appropriateness criteria for heart valve disease. It is divided according to common clinical scenarios: detection of valve disease, assessment of the valve and other cardiac structures, risk assessment, screening, and intervention. [less ▲]

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See detailChemical Strain Engineering of Magnetism in Oxide Thin Films
Copie, Olivier; Varignon, Julien ULg; Rotella, Hélène et al

in Advanced Materials (2017)

Transition metal oxides having a perovskite structure form a wide and technologically important class of compounds. In these systems, ferroelectric, ferromagnetic, ferroelastic, or even orbital and charge ... [more ▼]

Transition metal oxides having a perovskite structure form a wide and technologically important class of compounds. In these systems, ferroelectric, ferromagnetic, ferroelastic, or even orbital and charge orderings can develop and eventually coexist. These orderings can be tuned by external electric, magnetic, or stress field, and the cross-couplings between them enable important multifunctional properties, such as piezoelectricity, magneto-electricity, or magneto-elasticity. Recently, it has been proposed that additional to typical fields, the chemical potential that controls the concentration of ion vacancies in these systems may reveal an efficient alternative parameter to further tune their properties and achieve new functionalities. In this study, concretizing this proposal, the authors show that the control of the content of oxygen vacancies in perovskite thin films can indeed be used to tune their magnetic properties. Growing PrVO3 thin films epitaxially on an SrTiO3 substrate, the authors reveal a concrete pathway to achieve this effect. The authors demonstrate that monitoring the concentration of oxygen vacancies through the oxygen partial pressure or the growth temperature can produce a substantial macroscopic tensile strain of a few percent. In turn, this strain affects the exchange interactions, producing a nontrivial evolution of Néel temperature in a range of 30 K. [less ▲]

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