References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailA Bayesian path analysis to estimate causal effects of bazedoxifene acetate on incidence of vertebral fractures, either directly or through non-linear changes in bone mass density
Detilleux, Johann ULg; Reginster, Jean-Yves ULg; Chines, A. et al

in Statistical Methods in Medical Research (2016), 25(1), 400-412

Background/Aims Bone mass density values have been related with risk of vertebral fractures in post-menopausal women. However, bone mass density is not perfectly accurate in predicting risk of fracture ... [more ▼]

Background/Aims Bone mass density values have been related with risk of vertebral fractures in post-menopausal women. However, bone mass density is not perfectly accurate in predicting risk of fracture, which decreases its usefulness as a surrogate in clinical trials. We propose a modeling framework with three interconnected parts to improve the evaluation of bone mass density accuracy in forecasting fractures after treatment. Methods The modeling framework includes: (1) a piecewise regression to describe non-linear temporal BMD changes more accurately than crude percent changes, (2) a structural equation model to analyze interdependencies among vertebral fractures and their potential risk factors in preference to regression techniques that consider only directional associations, and (3) a counterfactual causal interpretation of the direct and indirect relationships between treatment and occurrence of vertebral fractures. We apply the methods to BMD repeated measurements from a study of the effect of bazedoxifene acetate on incident vertebral fractures in three different geographical regions. Results We made four observations: (1) bone mass density changes varied largely across participants, (2) baseline age and body mass index influenced baseline bone mass density that, in turn, had an effect on prevalent fractures, (3) direct and/or indirect effects of bazedoxifene acetate on incident fractures were different across regions, and (4) estimates of indirect effects were sensible to the presence of post-treatment unmeasured confounders. In one region, around 40% of the bazedoxifene acetate effect on the occurrence of fracture is explained by its effect on bone mass density. Under the counterfactual approach, these 40% represent the average difference in the occurrence of fracture observed for untreated individuals when their bone mass density values are set at the value under bazedoxifene acetate versus under placebo. Conclusions Computational methods are available to evaluate and interpret the surrogacytic capability of a biomarker of a primary outcome. © SAGE Publications 2012. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailRoyseux: a palaeobiodiversity hotspot in the Late Viséan (Carboniferous) of Belgium
Denayer, Julien ULg; Aretz, Markus; Poty, Edouard et al

in Geologica Belgica (2016), 19(1-2), 7-20

Detailed reference viewed: 25 (2 ULg)
Full Text
Peer Reviewed
See detailCombining microCT-based characterization with empirical modelling as a robust screening approach for the design of optimized CaP-containing scaffolds for progenitor cell-mediated bone formation.
Kerckhofs, G.; Chai, Y. C.; Luyten, F. P. et al

in Acta Biomaterialia (2016), 35

Biomaterials are a key ingredient to the success of bone tissue engineering (TE), which focuses on the healing of bone defects by combining scaffolds with cells and/or growth factors. Due to the widely ... [more ▼]

Biomaterials are a key ingredient to the success of bone tissue engineering (TE), which focuses on the healing of bone defects by combining scaffolds with cells and/or growth factors. Due to the widely variable material characteristics and patient-specificities, however, current bone TE strategies still suffer from low repeatability and lack of robustness, which hamper clinical translation. Hence, optimal TE construct (i.e. cells and scaffold) characteristics are still under debate. This study aimed to reduce the material-specific variability for cell-based construct design, avoiding trial-and-error, by combining microCT characterization and empirical modelling as an innovative and robust screening approach. Via microCT characterization we have built a quantitative construct library of morphological and compositional properties of six CE approved CaP-based scaffolds (CopiOs(R), BioOss, Integra Mozaik, chronOS Vivify, MBCP and ReproBone), and of their bone forming capacity and in vivo scaffold degradation when combined with human periosteal derived cells (hPDCs). The empirical model, based on the construct library, allowed identification of the construct characteristics driving optimized bone formation, i.e. (a) the percentage of beta-TCP and dibasic calcium phosphate, (b) the concavity of the CaP structure, (c) the average CaP structure thickness and (d) the seeded cell amount (taking into account the seeding efficiency). Additionally, the model allowed to quantitatively predict the bone forming response of different hPDC-CaP scaffold combinations, thus providing input for a more robust design of optimized constructs and avoiding trial-and error. This could improve and facilitate clinical translation. STATEMENT OF SIGNIFICANCE: Biomaterials that support regenerative processes are a key ingredient for successful bone tissue engineering (TE). However, the optimal scaffold structure is still under debate. In this study, we have provided a useful innovative approach for robust screening of potential biomaterials or constructs (i.e. scaffolds seeded with cells and/or growth factors) by combining microCT characterization with empirical modelling. This novel approach leads to a better insight in the scaffold parameters influencing progenitor cell-mediated bone formation. Additionally, it serves as input for more controlled and robust design of optimized CaP-containing bone TE scaffolds. Hence, this novel approach could improve and facilitate clinical translation. [less ▲]

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailAggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome.
Naves, Luciana A.; Daly, Adrian Francis ULg; Dias, Luiz Augusto et al

in Endocrine (2016)

X-linked acro-gigantism (X-LAG) syndrome is a newly described disease caused by microduplications on chromosome Xq26.3 leading to copy number gain of GPR101. We describe the clinical progress of a ... [more ▼]

X-linked acro-gigantism (X-LAG) syndrome is a newly described disease caused by microduplications on chromosome Xq26.3 leading to copy number gain of GPR101. We describe the clinical progress of a sporadic male X-LAG syndrome patient with an Xq26.3 microduplication, highlighting the aggressive natural history of pituitary tumor growth in the absence of treatment. The patient first presented elsewhere aged 5 years 8 months with a history of excessive growth for >2 years. His height was 163 cm, his weight was 36 kg, and he had markedly elevated GH and IGF-1. MRI showed a non-invasive sellar mass measuring 32.5 x 23.9 x 29.1 mm. Treatment was declined and the family was lost to follow-up. At the age of 10 years and 7 months, he presented again with headaches, seizures, and visual disturbance. His height had increased to 197 cm. MRI showed an invasive mass measuring 56.2 x 58.1 x 45.0 mm, with compression of optic chiasma, bilateral cavernous sinus invasion, and hydrocephalus. His thyrotrope, corticotrope, and gonadotrope axes were deficient. Surgery, somatostatin analogs, and cabergoline did not control vertical growth and pegvisomant was added, although vertical growth continues (currently 207 cm at 11 years 7 months of age). X-LAG syndrome is a new genomic disorder in which early-onset pituitary tumorigenesis can lead to marked overgrowth and gigantism. This case illustrates the aggressive nature of tumor evolution and the challenging clinical management in X-LAG syndrome. [less ▲]

Detailed reference viewed: 32 (16 ULg)
Full Text
Peer Reviewed
See detailThe CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity
Jourdan, Samuel ULg; Francis, Isolde; Kim, Min et al

in Scientific Reports (2016)

Detailed reference viewed: 26 (13 ULg)
Full Text
Peer Reviewed
See detailÂgisme et surestimation des difficultés cognitives des personnes âgées: une revue de la question
Marquet, Manon ULg; Missotten, Pierre ULg; Adam, Stéphane ULg

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2016), 14(2), 177-186

Stigmatization related to age (i.e., ageism) is a widespread phenomenon in the modern industrial societies where older people are perceived as cognitively incompetent. Therefore negative stereotypes about ... [more ▼]

Stigmatization related to age (i.e., ageism) is a widespread phenomenon in the modern industrial societies where older people are perceived as cognitively incompetent. Therefore negative stereotypes about age-related cognitive decline may have a detrimental influence on older adults on their cognitive performance. The aim of the present review is to understand how stereotypes can influence the performance of the elderly on cognitive tests. We first describe the stereotype threat phenomenon by providing an overview of situations likely to produce stereotype threat, as well as contextual and personal characteristics that moderate its effects. Possible mechanisms underlying these influences on cognitive performance are also presented. Secondly, we address self-stereotyping, which explains long-term negative effects of stereotypes and their unconscious influence on older adults’ cognitive performance. However, some age stereotypes have also positive effects on aged people, as shown by some studies describing such beneficial effects of positive stereotypes on cognitive performance. Finally we try to understand why negative age stereotyping has a much stronger influence on important behavioral outcomes among older adults than does positive age stereotyping. Given all these results, we examine how negative age stereotypes may impact older adults’ cognitive performance in real-world settings such as during a cognitive assessment. [less ▲]

Detailed reference viewed: 55 (7 ULg)
Full Text
Peer Reviewed
See detailUse of the potential probiotic strain Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers.
Saint-Cyr, Manuel Jimmy; Haddad, Nabila; Taminiau, Bernard ULg et al

in International Journal of Food Microbiology (2016)

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler ... [more ▼]

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler chicken will lower the risk to consumers. The aim of this project was to evaluate the ability of Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers and to investigate the mechanisms that could be involved. Thirty broilers artificially contaminated with C. jejuni were treated by oral gavage with MRS broth or a bacterial suspension (107CFU) of Lb. salivarius SMXD51 (SMXD51) in MRS broth. At 14 and 35days of age, Campylobacter and Lb. salivarius loads were assessed in cecal contents. The impact of the treatment on the avian gut microbiota at day 35 was also evaluated. At day 14, the comparison between the control and treated groups showed a significant reduction (P<0.05) of 0.82 log. After 35days, a significant reduction (P<0.001) of 2.81 log in Campylobacter loads was observed and 73% of chickens treated with the culture exhibited Campylobacter loads below 7log10CFU/g. Taxonomic analysis revealed that SMXD51 treatment induced significant changes (P<0.05) in a limited number of bacterial genera of the avian gut microbiota and partially limited the impact of Campylobacter on Anaerotruncus sp. decrease and Subdoligranulum sp. increase. Thus, SMXD51 exhibits an anti-Campylobacter activity in vivo and can partially prevent the impact of Campylobacter on the avian gut microbiota. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailIdentification of nonlinear normal modes of engineering structures under broadband forcing
Noël, Jean-Philippe ULg; Renson, Ludovic ULg; Grappasonni, Chiara ULg et al

in Mechanical Systems & Signal Processing (2016)

The objective of the present paper is to develop a two-step methodology integrating system identification and numerical continuation for the experimental extraction of nonlinear normal modes (NNMs) under ... [more ▼]

The objective of the present paper is to develop a two-step methodology integrating system identification and numerical continuation for the experimental extraction of nonlinear normal modes (NNMs) under broadband forcing. The first step processes acquired input and output data to derive an experimental state-space model of the structure. The second step converts this state-space model into a model in modal space from which NNMs are computed using shooting and pseudo-arclength continuation. The method is demonstrated using noisy synthetic data simulated on a cantilever beam with a hardening-softening nonlinearity at its free end. [less ▲]

Detailed reference viewed: 24 (4 ULg)
Full Text
Peer Reviewed
See detailA roadmap to multifactor dimensionality reduction methods.
Gola, Damian; Mahachie John, Jestinah M.; Van Steen, Kristel ULg et al

in Briefings in Bioinformatics (2016), 17(2), 293-308

Complex diseases are defined to be determined by multiple genetic and environmental factors alone as well as in interactions. To analyze interactions in genetic data, many statistical methods have been ... [more ▼]

Complex diseases are defined to be determined by multiple genetic and environmental factors alone as well as in interactions. To analyze interactions in genetic data, many statistical methods have been suggested, with most of them relying on statistical regression models. Given the known limitations of classical methods, approaches from the machine-learning community have also become attractive. From this latter family, a fast-growing collection of methods emerged that are based on the Multifactor Dimensionality Reduction (MDR) approach. Since its first introduction, MDR has enjoyed great popularity in applications and has been extended and modified multiple times. Based on a literature search, we here provide a systematic and comprehensive overview of these suggested methods. The methods are described in detail, and the availability of implementations is listed. Most recent approaches offer to deal with large-scale data sets and rare variants, which is why we expect these methods to even gain in popularity. [less ▲]

Detailed reference viewed: 7 (2 ULg)
Full Text
Peer Reviewed
See detailNew insights into sound production in Carapus mourlani (Carapidae)
Parmentier, Eric ULg; Colleye, Orphal ULg; Lecchini, David

in Bulletin of Marine Science (2016), 92(3),

Detailed reference viewed: 23 (3 ULg)
Full Text
See detailPatterns of Loving: Erna Brodber, Nothing's Mat
Romdhani, Rebecca ULg

in SX Salon: A Small Axe Literary Platform (2016), 21

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailCompte-rendu de l'ouvrage Cluny. Les moines et la société au premier age féodal
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

Detailed reference viewed: 32 (1 ULg)
Full Text
Peer Reviewed
See detailStudying Self-Awareness in Children: Validation of the Questionnaire of Executive Functioning (QEF)
Geurten, Marie ULg; Catale, Corinne ULg; Geurten, Claire ULg et al

in Clinical Neuropsychologist (The) (2016)

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of ... [more ▼]

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of appropriate instruments, few studies have examined the development of this ability among children. Method: This study tested the measurement properties of the self-rating and other-rating forms of the Questionnaire of Executive Functioning (QEF), designed to tap children’s knowledge of their executive functioning. Specifically, the construct, convergent, and discriminant validities were investigated and a self-other discrepancy score was computed to assess children’s executive self-awareness. Participants were 317 children aged 7 to 14 years old. Results: Confirmatory factor analyses carried out on the QEF confirmed the eight-factor structure of both versions. There were significant correlations between the QEF and the parent versions of the Behavior Rating Inventory of Executive Function, the Dysexecutive Questionnaire for Children, and the Childhood Executive Functioning Inventory. Both forms of the QEF were able to distinguish between children who had sustained a traumatic brain injury (TBI) and control participants. A statistical difference was observed between the TBI and control groups on this score, suggesting that TBI may trigger self-awareness impairments in children. Conclusion: The good psychometric properties of the two forms of the QEF were established. Furthermore, results of the analyses carried out on the different discrepancy scores seem to indicate that the QEF could help clinicians to detect patients with self-awareness deficits. [less ▲]

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailComparative study of output metrics for A MEMS resonant sensor consisting of three weakly coupled resonators
Zhao, Chun; Wood, Graham; Xie, J.B. et al

in Journal of Microelectromechanical Systems (2016)

Abstract—This paper systematically investigates the characteristics of different output metrics for a weakly coupled three degree-of-freedom microelectromechanical systems resonant sensor. The key figures ... [more ▼]

Abstract—This paper systematically investigates the characteristics of different output metrics for a weakly coupled three degree-of-freedom microelectromechanical systems resonant sensor. The key figures-of-merit examined are sensitivity and linear range. The four main output metrics investigated are mode frequency shift, amplitude difference, amplitude ratio, and eigenstate shift. It is shown from theoretical considerations, equivalent RLC circuit model simulations and electrical measurements, that there is a strong tradeoff between sensitivity and linear range. For instance, the amplitude difference has the best sensitivity but the worst linear range, whereas frequency shift has the widest linear range but the lowest sensitivity. We also show that using the vibrational amplitude ratio as an output metric provides the best balance between sensitivity and linear range. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailĐánh giá tiềm năng sử dụng phụ phẩm ngành rượu cồn để sản xuất thức ăn chăn nuôi tại Việt Nam
Tu Viet, Phu; Pham Kim, Dang; Nguyen Cong, Oanh ULg et al

in Journal of Science and Development (2016), 14(1), 36-45

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high ... [more ▼]

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high feed price due to the dependence on imported raw materials (estimated at 65-70%). The total value of imported raw materials for animal feed production in 2013 was estimated at $ 4.1 billion. Worldwide, by-products from alcohol industry has been studied and processed into main raw materials (DDG and DDGS) for animal feed production. Meanwhile in our country, these by-products are used in its raw form in livestock feeding or used for other purposes with low economic benefit. The objective of this study was to evaluate the potential uses of the by-products from alcohol industry to produce animal feed and increase the added value for these products. The main methods used in this study were Value Chain Analysis (VCA) and SWOT analysis. Results of the study showed the different value chains of the alcohol industry as well as opportunities for the use of by-products for the production of animal feed. The results also indicate the difficulties and challenges of these application. [less ▲]

Detailed reference viewed: 42 (10 ULg)
Full Text
Peer Reviewed
See detailWhere do hybrids come from? Entrepreneurial team heterogeneity as an avenue for the emergence of hybrid organizations
Dufays, Frédéric ULg; Huybrechts, Benjamin ULg

in International Small Business Journal (2016), 34(6), 777-796

This conceptual paper aims to respond to the poorly addressed question of the emergence of hybrid organizations – i.e. organizations that embrace several institutional logics. It does so by developing a ... [more ▼]

This conceptual paper aims to respond to the poorly addressed question of the emergence of hybrid organizations – i.e. organizations that embrace several institutional logics. It does so by developing a model and a set of propositions focusing on the heterogeneity of the entrepreneurial team as a possible driver for hybridity throughout the entrepreneurial process and up to the emergence of a hybrid organization. As contributions to the literatures on (collective) entrepreneurship, imprinting and hybrid organizations, we advance several avenues and conditions under which the heterogeneity of the entrepreneurial team may imprint the entrepreneurial process and lead to the creation of hybrid organizations. Our propositions connect the individual, team and organizational levels and thus advance our understanding of how institutional logics can be combined across different levels of analysis and throughout the stages of an entrepreneurial process. [less ▲]

Detailed reference viewed: 175 (14 ULg)
Full Text
Peer Reviewed
See detailRecent Advances on the Oil-Free Scroll Compressor
Bin, Peng; Legros, Arnaud; Lemort, Vincent ULg et al

in Recent Patents on Mechanical Engineering (2016), 9

Traditionally, scroll compressors are mainly made of metallic parts and oil is used to lubricate the friction surfaces and reduce discharge temperature and leakage. But for the food processing, medical ... [more ▼]

Traditionally, scroll compressors are mainly made of metallic parts and oil is used to lubricate the friction surfaces and reduce discharge temperature and leakage. But for the food processing, medical systems, textile manufacturing, fuel cell system, and other super-clean fields, the oil-less operation is critical. The oil is strictly forbidden in the working chambers of the scroll compressor in order to get the oil-free compressed air. So it is very important to develop the oil-free scroll compressor (OFSC). In this paper, the working principle and structure characteristics of the OFSC are investigated. Some of research works and the recent patents in this area are described and analyzed in detail, especially the water injection and air cooling OFSC. The future development on an OFSC is also presented. The analysis results demonstrated that there is dramatic growth potential in OFSC field. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailUse of a multivariate moving window PCA for the untargeted detection of contaminants in agro-food products, as exemplified by the detection of melamine levels in milk using vibrational spectroscopy.
Fernandez Pierna, Juan A; Vincke, Damien; Baeten, Vincent et al

in Chemometrics and Intelligent Laboratory Systems (2016)

Detailed reference viewed: 19 (5 ULg)
Full Text
Peer Reviewed
See detailTemperature and moisture storage in crop-based materials: Modelling a straw bale wall subject to a thermal shock
Dubois, Samuel ULg; Evrard, Arnaud ULg; Blecker, Christophe ULg et al

in Jounal of Building Physics (2016)

Modelling the hygrothermal behaviour of crop-based insulation products is essential to assess their impact on the energy performance of the building, predict indoor climate conditions, and prevent any ... [more ▼]

Modelling the hygrothermal behaviour of crop-based insulation products is essential to assess their impact on the energy performance of the building, predict indoor climate conditions, and prevent any risk of unexpected degradation. Traditionally, transient numerical models that predict internal conditions of construction materials consider that the variation of moisture storage with temperature is negligible although the sorp- tion behaviour is known to be temperature dependent. This paper investigates this par- ticular effect for crop-based materials and uses a refinement of standard mathematical representations. For this purpose, the effects of a thermal shock on the evolution of hygrothermal conditions inside a straw-bale wall are studied with several versions of a flexible research model. The latter is capable of incorporating the temperature depen- dency of the sorption curve with both a physically-based and an empirical description. A large climate chamber is used to gather experimental data and is able to host a full- size straw bale prefabricated panel. Internal conditions of straw bales are obtained with proper sensors bars. Results show that when large temperature gradients occur in a crop-based material, a model that considers temperature effect on moisture storage enhances greatly the prediction of internal conditions. [less ▲]

Detailed reference viewed: 76 (10 ULg)
Full Text
Peer Reviewed
See detailGenetic diversity, Population structure, parentage analysis, and construction of core collections in the French apple germplasm based on SSR markers
Lassois, Ludivine ULg; Denancé, Caroline; Ravon, Elisa et al

in Plant Molecular Biology Reporter (2016), 34(4), 827-844

In-depth characterization of apple genetic resources is a prerequisite for genetic improvement and for germplasm management. In this study, we fingerprinted a very large French collection of 2163 ... [more ▼]

In-depth characterization of apple genetic resources is a prerequisite for genetic improvement and for germplasm management. In this study, we fingerprinted a very large French collection of 2163 accessions with 24 SSR markers in order to evaluate its genetic diversity, population structure and genetic relationships, to link these features with cultivar selection date or usage (old or modern, dessert or cider cultivars), and to construct core collections. Most markers were highly discriminating and powerful for varietal identification, with a probability of identity P(ID) over the 21 retained SSR loci close to 10-28. Pairwise comparisons revealed 34% redundancy and 18.5% putative triploids. The results showed that the germplasm is highly diverse with an expected heterozygosity He of 0.82 and observed heterozygosity Ho of 0.83. A Bayesian model-based clustering approach revealed a weak but significant structure in three subgroups (FST = 0.014-0.048) corresponding, albeit approximately, to the three subpopulations defined beforehand (Old Dessert, Old Cider and Moderncultivars). Parentage analyses established already known and yet unknown relationships, notably between old cultivars, with the frequent occurrence of cultivars such as ‘King of Pippin’ and ‘Calville Rouge d’Hiver’ as founders. Finally, core collections based on allelic diversity were constructed. A large dessert core collection of 278 cultivars contained 90% of the total dessert allelic diversity, whereas a dessert sub-core collection of 48 cultivars contained 71% of diversity. For cider apples, a 48-cultivars core collection contained 83% of the total cider allelic diversity. [less ▲]

Detailed reference viewed: 50 (8 ULg)
Full Text
Peer Reviewed
See detailThe network model of depression as a basis for new therapeutic strategies for treating major depressive disorder in Parkinson’s disease
D'Ostilio, Kevin ULg; Garraux, Gaëtan ULg

in Frontiers in Human Neuroscience (2016), 10(161),

The high prevalence of major depressive disorder in people with Parkinson's disease, its negative impact on health-related quality of life and the low response rate to conventional pharmacological ... [more ▼]

The high prevalence of major depressive disorder in people with Parkinson's disease, its negative impact on health-related quality of life and the low response rate to conventional pharmacological therapies call to seek innovative treatments. Here, we review the new approaches for treating major depressive disorder in patients with Parkinson's disease within the framework of the network model of depression. According to this model, major depressive disorder reflects maladaptive neuronal plasticity. Non-invasive brain stimulation using high frequency repetitive transcranial magnetic stimulation over the prefrontal cortex has been proposed as a feasible and effective strategy with minimal risk. The neurobiological basis of its therapeutic effect may involve neuroplastic modifications in limbic and cognitive networks. However, the way this networks reorganize might be strongly influenced by the environment. To address this issue, we propose a combined strategy that includes non-invasive brain stimulation together with cognitive and behavioral interventions. [less ▲]

Detailed reference viewed: 32 (4 ULg)
Full Text
Peer Reviewed
See detailThe unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
Figueroa Yévenes, Maximiliano ULg; Sleutel, Mike; Vandevenne, Marylène ULg et al

in Journal of structural biology (2016)

Despite impressive successes in protein design, designing a well-folded protein of more 100 amino acids de novo remains a formidable challenge. Exploiting the promising biophysical features of the ... [more ▼]

Despite impressive successes in protein design, designing a well-folded protein of more 100 amino acids de novo remains a formidable challenge. Exploiting the promising biophysical features of the artificial protein Octarellin V, we improved this protein by directed evolution, thus creating a more stable and soluble protein: Octarellin V.1. Next, we obtained crystals of Octarellin V.1 in complex with crystallization chaperons and determined the tertiary structure. The experimental structure of Octarellin V.1 differs from its in silico design: the (alphabetaalpha) sandwich architecture bears some resemblance to a Rossman-like fold instead of the intended TIM-barrel fold. This surprising result gave us a unique and attractive opportunity to test the state of the art in protein structure prediction, using this artificial protein free of any natural selection. We tested 13 automated webservers for protein structure prediction and found none of them to predict the actual structure. More than 50% of them predicted a TIM-barrel fold, i.e. the structure we set out to design more than 10years ago. In addition, local software runs that are human operated can sample a structure similar to the experimental one but fail in selecting it, suggesting that the scoring and ranking functions should be improved. We propose that artificial proteins could be used as tools to test the accuracy of protein structure prediction algorithms, because their lack of evolutionary pressure and unique sequences features. [less ▲]

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailN-Acetylcysteine: An Old Drug With Variable Anti-Influenza Properties
Casanova, Tomas; Garigliany, Mutien-Marie ULg

in Journal of Controversies in Biomedical Research (2016)

Detailed reference viewed: 23 (1 ULg)
Full Text
Peer Reviewed
See detailStaphylococcus aureus genotype B and other genotypes isolated from cow milk in European countries.
Cosandey, A.; Boss, R.; Luini, M. et al

in Journal of dairy science (2016), 99(1), 529-40

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies, however, have demonstrated in Swiss cows that Staph. aureus isolated from ... [more ▼]

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies, however, have demonstrated in Swiss cows that Staph. aureus isolated from bovine intramammary infection is genetically heterogeneous, with Staph. aureus genotype B (GTB) and GTC being the most prominent genotypes. In addition, Staph. aureus GTB was found to be contagious, whereas Staph. aureus GTC and all the remaining genotypes were involved in individual cow disease. The aim of this study was to subtype strains of Staph. aureus isolated from bovine mastitic milk and bulk tank milk to obtain a unified view of the presence of bovine staphylococcal subtypes in 12 European countries. A total of 456 strains of Staph. aureus were subjected to different typing methods: ribosomal spacer PCR, detection of enterotoxin genes, and detection of gene polymorphisms (lukE, coa). Major genotypes with their variants were combined into genotypic clusters (CL). This study revealed 5 major CL representing 76% of all strains and comprised CLB, CLC, CLF, CLI, and CLR. The clusters were characterized by the same genetic properties as the Swiss isolates, demonstrating high clonality of bovine Staph. aureus. Interestingly, CLB was situated in central Europe whereas the other CL were widely disseminated. The remaining 24% of the strains comprised 41 genotypes and variants, some of which (GTAM, GTBG) were restricted to certain countries; many others, however, were observed only once. [less ▲]

Detailed reference viewed: 20 (7 ULg)
Full Text
Peer Reviewed
See detailPolyphasic characterization of 10 selected ecologically relevant filamentous cyanobacterial strains from the South Shetland Islands, Maritime Antarctica
Jancusova, Miroslava; Kovacik, Lubomir; Pereira, Antonio Batista et al

in FEMS Microbiology Ecology (2016), 92(7), 100

The evolutionary relationships of 10 Antarctic cyanobacterial strains of the order Oscillatoriales isolated from King George and Deception Islands, South Shetland Islands were studied by a polyphasic ... [more ▼]

The evolutionary relationships of 10 Antarctic cyanobacterial strains of the order Oscillatoriales isolated from King George and Deception Islands, South Shetland Islands were studied by a polyphasic approach (morphology, 16S rRNA and internal transcribed spacer sequences). The studied taxa are characteristic of coastal Antarctic biotopes, where they form distinct populations and ecologically delimited communities. They were isolated from terrestrial habitats: microbial mats in seepages; crusts on soil, rocks, bones and mosses; mud, sometimes close to bird colonies; and from guano. Based on major phenotypic features, the strains were divided into four distinct morphotypes: Leptolyngbya borchgrevinkii (A), Leptolyngbya frigida (B), Microcoleus sp. (C) and Wilmottia murrayi (D). This morphological identification was in agreement with the phylogenetic relationships. For the first time, the 16S rRNA gene sequence of a strain corresponding to the L. borchgrevinkii morphotype was determined. Morphotype B is most related to sequences assigned to L. frigida isolated from microbial mats of coastal lakes in East Antarctica. Morphotype C belongs to a cluster including strains with morphotypes corresponding to Microcoleus attenuatus, Microcoleus favosus and Microcoleus sp., which are from Antarctica and other continents. Morphotype D is grouped with sequences assigned to W. murrayi mostly isolated from Antarctica. [less ▲]

Detailed reference viewed: 16 (4 ULg)
Full Text
Peer Reviewed
See detailEffects of planting methods and tuber weights on growth and yield of yam cultivars (Dioscorea rotundata Poir.) in Gabon
ONDO OVONO, Paul; Kevers, Claire ULg; Dommes, Jacques ULg

in International Research Journal of Agricultural Science and soil Science (2016), 6

A study was conducted to investigate the influence of planting methods and tuber weight on growth and yield of local yam cultivars obtained by the minisett technique from white yam (D. rotundata) in Gabon ... [more ▼]

A study was conducted to investigate the influence of planting methods and tuber weight on growth and yield of local yam cultivars obtained by the minisett technique from white yam (D. rotundata) in Gabon. Trials were carried out in 2014 and 2015 at the experimental ground of the Higher National Institute of Agronomy and Biotechnology, under natural conditions of lightness, temperature and relative humidity. Twenty- four weeks old mini tubers obtained from local cultivar MVA of D. rotundata were harvested, weighed and categorized ( 40-80 g; 100-150 g; 200-300 g), and three planting methods (horizontal, oblique and vertical), arranged in ridges constituted the main factors. The experiment was laid out in Randomized Completely Block Design with eighteen treatments and two replications. Data pertaining to sprouting were recorded for 30, 60, 90 and 180 DAP, for tuber length (cm), tuber weight (Kg) and number of tubers per plant 270 DAP. Significant differences among tuber weight in all variables tested were observed. The larger tubers had better sprouting ability than the rest of the tuber weight. The methods of planting had no effects on yield and its components but they affect the depth and spread of tubers. Vertical planting produced deeper but more compactly arranged tubers while horizontal planting produced tubers which were shallower but more widespread. Slanting was intermediate for both depth and spread. The number and weight of tubers obtained from mini tubers planted out according to slanting method were significantly different (P< 0.05) from other planting methods. The production of seedlings from mini tuber is an improvement of traditional production of seed yam. Mini tubers must have at least 100-300 g and they should be planted slanting or vertically. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailMechanically-coupled ring-resonator filter and array (analytical and finite element model).
Pachkawade, Vinayak ULg; Junghare, R; Patrikar, R et al

in IET Computers & Digital Techniques (2016)

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band ... [more ▼]

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band-pass filter with centre frequency of 4.4 MHz and a small bandwidth of only 36 kHz. Flexural-mode ring resonators have been mechanically coupled using soft mechanical spring for realising the filtering action. Owing to inherent symmetry in the ring structure, simple approach is used to access a low-velocity coupling locations to set a smallest possible bandwidth. The authors also show a reduction in the amplitude of spurious mode by accentuating the filter structure in its fully differential mode inherently present in the structure. Moreover, the effect of the number of the support beams and structural damping on the frequency response of a filter has been analysed. A second device is mechanically coupled ring-resonator arrays with varying number of rings coupled. The mechanical links using short stubs connect each constituent resonator of an array to its adjacent ones at the high-velocity vibrating locations to accentuate the desired mode and reject all other spurious modes. Both analytical and finite-element based simulation results for parameters of the designed structure are found in good agreement. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailProcedural learning, consolidation, and transfer of a new skill in Developmental Coordination Disorder
Lejeune, Caroline ULg; Wansard, Murielle ULg; Geurten, Marie ULg et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016), 22(2),

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill ... [more ▼]

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill automatization (i.e., the stages of fast learning, consolidation, and slow learning). Transfer of the skill to a new situation was also assessed. We tested 34 children aged 6–12 years with and without DCD on a perceptuomotor adaptation task, a form of procedural learning that is thought to involve the cerebellum and the basal ganglia (regions whose impairment has been associated with DCD) but also other brain areas including frontal regions. The results showed similar rates of learning, consolidation, and transfer in DCD and control children. However, the DCD children's performance remained slower than that of controls throughout the procedural task and they reached a lower asymptotic performance level; the difficulties observed at the outset did not diminish with practice. [less ▲]

Detailed reference viewed: 29 (10 ULg)
Full Text
Peer Reviewed
See detailReflectometry with an open-source Software GNSS Receiver. Use Cases with Carrier Phase Altimetry.
Lestarquit, Laurent; Peyrezabes, Mathieu; Darrozes, José et al

in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2016)

An open-source GNSS software receiver allows to have full access to the signal processing and to make add-ons to the source code in order to obtain the desired GNSS reflectometry processing. The direct ... [more ▼]

An open-source GNSS software receiver allows to have full access to the signal processing and to make add-ons to the source code in order to obtain the desired GNSS reflectometry processing. The direct signal is processed in the standard way, its tracking loops replica are tapped to have a robust processing of the reflected signal in a master-slave configuration, with the very same carrier replica used to correlate the reflected signal. Additionally, the data bit sign is wiped off, which allows to extend the coherent integration time (CIT) well beyond the usual 20 milliseconds limit on the reflected way. This allows having a straightforward and accurate measurement of the Amplitude Ratio and Differential Carrier Phase between the direct and reflected signal. The possible applications are precise carrier phase altimetry and any application requiring signal amplitude ratio, or reflected signal Delay Map, with single or dual polarization, this includes code altimetry, humidity, biomass, soil roughness, ocean surface wind and wave height, snow and ice characteristics retrieval. This software is intended to be used as a research tool. It has been tested for carrier phase altimetry on real data sets collected in rather calm water conditions: at the 60 meter Cordouan Lighthouse, and during a 600 meter high ATR42 flight over a lake. In both case, continuous carrier phase measurement with a centimeter level precision were obtained when extending the CIT up to 500 ms. Increasing the CIT beyond 20 ms is the key to improve carrier phase altimetry robustness. [less ▲]

Detailed reference viewed: 34 (0 ULg)
Full Text
Peer Reviewed
See detailJack-of-all-trades effects drive biodiversity-ecosystem multifunctionality relationships in European forests.
van der Plas, Fons; Manning, Peter; Allan, Eric et al

in Nature communications (2016), 7

There is considerable evidence that biodiversity promotes multiple ecosystem functions (multifunctionality), thus ensuring the delivery of ecosystem services important for human well-being. However, the ... [more ▼]

There is considerable evidence that biodiversity promotes multiple ecosystem functions (multifunctionality), thus ensuring the delivery of ecosystem services important for human well-being. However, the mechanisms underlying this relationship are poorly understood, especially in natural ecosystems. We develop a novel approach to partition biodiversity effects on multifunctionality into three mechanisms and apply this to European forest data. We show that throughout Europe, tree diversity is positively related with multifunctionality when moderate levels of functioning are required, but negatively when very high function levels are desired. For two well-known mechanisms, 'complementarity' and 'selection', we detect only minor effects on multifunctionality. Instead a third, so far overlooked mechanism, the 'jack-of-all-trades' effect, caused by the averaging of individual species effects on function, drives observed patterns. Simulations demonstrate that jack-of-all-trades effects occur whenever species effects on different functions are not perfectly correlated, meaning they may contribute to diversity-multifunctionality relationships in many of the world's ecosystems. [less ▲]

Detailed reference viewed: 23 (11 ULg)
Full Text
Peer Reviewed
See detailSmall-Angle Scattering Analysis of Empty or Loaded Hierarchical Porous Materials
Gommes, Cédric ULg; Prieto, Gonzalo; de Jongh, Petra

in Journal of Physical Chemistry C (2016), 120(3), 14881506

Small-angle scattering of x-rays (SAXS) or neutrons (SANS) is one of the few experimental methods that can in principle be used for the in situ study at the mesoscopic scale of physicochemical phenomena ... [more ▼]

Small-angle scattering of x-rays (SAXS) or neutrons (SANS) is one of the few experimental methods that can in principle be used for the in situ study at the mesoscopic scale of physicochemical phenomena occurring inside nanoporous solids. However, the potential of the method is often limited by the lack of suitable data analysis methods to convert scattering data into real-space structural information. This is notably the case for most porous materials of practical interest, which exhibit a hierarchical structure with micro, meso, and macropores, with often a secondary material confined in the pores, such as in supported catalysts, as well as fuel-cell and battery materials. In the present contribution, we propose a general analysis of x-ray scattering by this type of material. Assuming that each structural level is statistically independent from the others and has a distinct characteristic length scale, compact mathematical expressions are derived for the scattering of the entire hierarchical structure. The results are particularised to the SAXS analysis of SBA-15 ordered mesoporous silica loaded with copper nitrate as well as to supported catalysts obtained after heat treatment of that material. The SAXS data analysis shows that the nitrate fills both the micro and mesopores of the material, while the metallic copper obtained after heat treatment is found only in the mesopores. Moreover, the mesoscopic-scale spatial distribution of the metal depends on the heat treatment, in line with earlier electron tomography studies. The main ideas underlying the SAXS data analysis were presented in an recent Communication [Gommes et al., Angew. Chem. Intl. Ed. 54 (2015) 11804-11808]. Here we generalise the approach and we provide a comprehensive discussion of how any level in a hierarchical structure contributes to its overall scattering pattern. The results, as well as the general modelling methodology, will be of interest to anyone interested in the quantitative analysis of small-angle scattering data of empty or loaded porous solids, and more generally of any type of hierarchical material. [less ▲]

Detailed reference viewed: 147 (16 ULg)
Full Text
Peer Reviewed
See detailLa empresa social en Bélgica: diversidad de fuentes, modelos y campos
Huybrechts, Benjamin ULg

in Revista de la Academia (2016), 21

Este artículo está estructurado como sigue: la primera sección introductoria revisa las principales raíces históricas que han conduci- do a la emergencia de una diversidad de modelos relacionados con la ... [more ▼]

Este artículo está estructurado como sigue: la primera sección introductoria revisa las principales raíces históricas que han conduci- do a la emergencia de una diversidad de modelos relacionados con la empresa social y a la economía social en Bélgica. Enseguida, la segunda sección esboza los principales aspectos de esos modelos en relación a sus formas legales, tipos de misión social a las que se orientan, dinámicas de gobierno y recursos. En la tercera sección, esos modelos son ilustrados in diferentes campos de actividad, tanto establecidos como emergentes. Finalmente, la cuarta sección propone un análisis transversal de los principales tendencias y desafíos que enfrenta el desarrollo y coexisten- cia de los diferentes modelos. [less ▲]

Detailed reference viewed: 20 (0 ULg)
Full Text
Peer Reviewed
See detailPhysical, functional and structural characterization of the cell wall fractions from baker's yeast Saccharomyces cerevisiae
Borchani, C.; Fonteyn, F.; Jamin, G. et al

in Food Chemistry (2016), 194

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast ... [more ▼]

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast cell wall fractionation process involving enzymatic treatments (savinase and lipolase enzymes) affected most of the physical and functional characteristics of extracted fractions. Thus, the fractionation process showed that β-D-glucan fraction F4 had significantly higher swelling power and fat binding capacity compared to other fractions (F1, F2 and F3). It also exhibited a viscosity of 652.12 mPa s and a high degree of brightness of extracted β-D-glucan fraction. Moreover, the fractionation process seemed to have an effect on structural and thermal properties of extracted fractions. Overall, results showed that yeast β-D-glucan had good potential for use as a prebiotic ingredient in food, as well as medicinal and pharmaceutical products. © 2015, Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 111 (0 ULg)
Full Text
Peer Reviewed
See detailEvaluation of anode (electro)catalytic materials for the direct borohydride fuel cell: methods and benchmarks
Olu, Pierre-Yves ULg; Job, Nathalie ULg; Chatenet, Marian

in Journal of Power Sources (2016), 327

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailDifferential somatic Ca2+ channel profile in midbrain dopaminergic neurons
Philippart, Fabian ULg; Destreel, Geoffrey ULg; Merino-Sepulveda, Paulina et al

in Journal of Neuroscience (2016)

Dopaminergic (DA) neurons located in the ventral midbrain continuously generate a slow endogenous pacemaker activity, the mechanism of which is still debated. It has been suggested that, in the substantia ... [more ▼]

Dopaminergic (DA) neurons located in the ventral midbrain continuously generate a slow endogenous pacemaker activity, the mechanism of which is still debated. It has been suggested that, in the substantia nigra pars compacta (SNc), the pacemaking relies more on Ca2+ channels and that the density of L type Ca2+ channels is higher in these DA neurons than in those located in the ventral tegmental area (VTA). This might lead to a higher Ca2+ load in SNc DA neurons, and explain their higher susceptibility to degeneration. However, direct evidence for this hypothesis is lacking. We found that the L-type current and channel density is indeed higher in the somata of rat SNc DA neurons, and that this current undergoes less inactivation in this region. Non stationary fluctuation analysis (NSFA) measurements showed a much higher number of L-type channels in the soma of SNc DA neurons, as well as a smaller single channel conductance, pointing to a possible different molecular identity of L-type channels in DA neurons from the two areas. A major consequence of this is that pacemaking and even more so bursting are associated with a larger Ca2+ entry through L-type channels in SN DA neurons than in their VTA counterparts. Our results establish a molecular and functional difference between two populations of midbrain DA neurons that may contribute to their differential sensitivity to neurodegeneration. [less ▲]

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailForeign Language Teachers’ Assessment Practices in French-Speaking Belgium’s Upper Secondary Schools: A Case Study
Noiroux, Kevin ULg

in The International Journal of Pedagogy and Curriculum (2016), 23(2),

Foreign language classroom assessment practices are a mystery, at least in Belgium. The present case study aims at shedding light on Belgian foreign languages teachers’ assessment practices in secondary ... [more ▼]

Foreign language classroom assessment practices are a mystery, at least in Belgium. The present case study aims at shedding light on Belgian foreign languages teachers’ assessment practices in secondary education. I interviewed seven teachers to know what they assessed and how often they assessed it. I also analyzed the legal provisions that teachers have to respect when they assess. The results show that teachers assess four communicative skills—listening, reading, writing, and speaking—as legally required, but also reveal that they frequently assess vocabulary and grammar, sometimes in ways that are not permitted. Furthermore, they spend a considerable amount of time assessing those skills without even being aware of it. Since these assessments only aim at verifying that the students master the skills, it may be worth investigating whether some assessments are not redundant so as to devote that time to a more productive task. [less ▲]

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailThe effect of pre-industrial charcoal kilns on chemical properties of forest soil of Wallonia, Belgium
Hardy, Brieuc; Cornelis, Jean-Thomas ULg; Houben, David et al

in European Journal of Soil Science (2016)

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailVariable thickness scroll compressor performance analysis—Part II: Dynamic modeling and model validation
Bin, Peng; Lemort, Vincent ULg; Legros, Arnaud et al

in Proc IMechE Part E: J Process Mechanical Engineering (2016)

In order to investigate the performance of variable thickness scroll compressor, a detail mathematical modeling based on energy and mass balances is established in this two-part. In part II, dynamic ... [more ▼]

In order to investigate the performance of variable thickness scroll compressor, a detail mathematical modeling based on energy and mass balances is established in this two-part. In part II, dynamic modeling and model validation are developed. Temperature, pressure, mass flow of working chambers, friction loss power of moving parts, efficiency, and shaft power are investigated by solving the mathematical modeling. The experimental rig for variable thickness scroll compressor based on involute of circle, high order curve and arc is set up. From the comparison of the simulated and measured data, it can be seen that the compressor model predicts the mass flow, discharge temperature, and shaft power very well. So the proposed mathematical modeling can accurately describe all the suction, compression, and discharge processes for variable thickness scroll compressor. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailRadio-frequency magnetron sputtering: a versatile tool for CdSe quantum dots depositions with controlled properties
Dahi, Abdellatif; Colson, Pierre ULg; Jamin, Claire et al

in Journal of Material and Environmental Sciences (2016), 7(7), 2277-2287

CdSe nanoparticles are of great interest for many applications. However, their size, shape, and aggregation are still difficult to control by the conventional synthesis methods. Here, we report on the ... [more ▼]

CdSe nanoparticles are of great interest for many applications. However, their size, shape, and aggregation are still difficult to control by the conventional synthesis methods. Here, we report on the synthesis of CdSe quantum dots (QDs), with an average diameter less than 10 nm, using radio-frequency magnetron sputtering (RFMS) on glass and silicon substrates at 25 °C. First, results show that a target-substrate distance of 13.5 cm and a chamber pressure of 2.2 .10-1 mbar were required to deposit a CdSe QDs layer on the substrates. The morphology and optical properties of CdSe QDs were then studied as a function of RF power and deposition time. The size of CdSe QDs increases with increasing both the RF power and the deposition time. UV-visible spectroscopy shows that the CdSe QDs layer deposited on the glass-substrate by RFMS has almost the same optical properties as the one obtained from commercial CdSe QDs solutions. In both cases, a shift of the characteristic absorption band of CdSe QDs towards the higher wavenumbers is observed with the QDs size increase. AFM confirms the success of CdSe QDs layer deposition by RFMS: CdSe QDs with a mean diameter of 7.5 ± 2 nm were observed for a RF power of 14 W, a chamber pressure of 2.2 .10-1 mbar, a target-substrate distance of 13.5 cm and a deposition time of 7.5 min (optimal values). With these parameters, the coverage of the substrate by the nano-objects is estimated at 25-30 % of the overall surface. [less ▲]

Detailed reference viewed: 46 (8 ULg)
Full Text
See detailAménagements raisonnables et travailleurs en situation de handicap : pistes de recherche sociologiques
Lejeune, Aude ULg

in Actes du colloques "Situations de Handicap et Aménagements Raisonnables" (2016)

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailAn investigation of structural dimension variation in electrostatically-coupled MEMS resonator pairs using mode-localization
Wood, Graham; Chun, Zhao; Pu, Suan et al

in IEEE Sensors Journal (2016)

If a pair of MEMS resonators are electrostatically coupled together, the vibration amplitude ratios at the resonant frequencies of the resulting coupled system are sensitive to stiffness perturbation. An ... [more ▼]

If a pair of MEMS resonators are electrostatically coupled together, the vibration amplitude ratios at the resonant frequencies of the resulting coupled system are sensitive to stiffness perturbation. An imbalance between the two resonators causes the confinement of vibration energy when the system is resonating, an effect known as mode-localization. The degree of localization can be determined by extracting the amplitude ratio of the resonators through capacitive transduction. In this paper, we have fabricated MEMS devices, using a dicing-free silicon-on-insulator process, consisting of pairs of closely spaced microresonators. Each resonator consists of a clamped-clamped beam with a wider section in the middle, which is the location of the electrostatic coupling, instituted through the DC biasing of the resonators. Several devices have been fabricated, with the length of the anchor beams being varied, which influences the frequency of resonance. Stiffness imbalance between the resonators has been introduced through electrostatic spring softening, with the sensitivity of the amplitude ratio of the resonant mode shape being greater for the higher frequency, shorter anchor devices. The sensitivities of the devices in this study have been found to be 9 times greater than state-of-the-art two-degree-of-freedom mode-localized sensors. [less ▲]

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailComment je traite ....... Le delirium chez le patient âgé
CHRISTELBACH, Sophie ULg; ALLEPAERTS, Sophie ULg; PETERMANS, Jean ULg

in Revue Médicale de Liège (2016)

Detailed reference viewed: 27 (8 ULg)
Full Text
Peer Reviewed
See detailMetastable inhomogeneous vortex configuration with non-uniform filling fraction inside a blind hole array patterned in a BSCCO single crystal and concentrating magnetic flux inside it
Shaw, Gorky ULg; Banerjee, S. S.; Tamegai, T. et al

in Superconductor Science and Technology (2016), 29(6), 065021

Detailed reference viewed: 12 (6 ULg)
Full Text
Peer Reviewed
See detailVirtual Issue celebrating the 100th volume of the Journal of Animal Physiology and Animal Nutrition
Fascetti, A. J.; Everaert, Nadia ULg

in Journal of Animal Physiology and Animal Nutrition (2016), 100(1), 1-2

[No abstract available]

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailElectromechanical Sigma-Delta Modulators (EMSDM) force feedback interfaces for capacitive MEMS inertial sensors: a review
Chen, Fang; Li, Xinxin; Kraft, Michael ULg

in IEEE Sensors Journal (2016)

Analog-to-digital converters (ADC) based on sigma-delta modulators (SDM) are a popular choice for high resolution conversion from the analog to the digital domain. With relatively small modifications they ... [more ▼]

Analog-to-digital converters (ADC) based on sigma-delta modulators (SDM) are a popular choice for high resolution conversion from the analog to the digital domain. With relatively small modifications they also can be used as electromechanical SDM (EM-SDM) force feedback interfaces for capacitive micro-electromechanical systems (MEMS) inertial sensors. Such interfaces are able to combine the benefits of force feedback and analog to digital conversion at relatively modest circuit cost. This paper provides a comprehensive review of EM-SDM interfaces for capacitive MEMS inertial sensors. The principle and design methodology of EM-SDM interfaces are introduced. A classification of EM-SDMaccelerometers and gyroscopes is presented, and a detailed analysis of different EM-SDMarchitectures is given. The most representative EM-SDM inertial sensors systems are discussed and compared with regard to their performance characteristics. In particular, the properties of various discrete and continuous-time techniques and a system parameter optimization methodology are illustrated through specific examples. Finally, current challenges and future development trends of EM-SDM interfaces for inertial sensors have been identified. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailLes Alarmes de Mars de Jean d'Auton. Édition et commentaire
Dumont, Jonathan ULg

in Annuaire - Bulletin de la Société de l'Histoire de France (2016), 551

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailIL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis.
Humblet-Baron, Stephanie; Franckaert, Dean; Dooley, James et al

in Journal of Allergy and Clinical Immunology (The) (2016), 138(1), 200-2098

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic ... [more ▼]

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic lymphohistiocytosis (FHL) forms. In both conditions, a sterile or infectious trigger is required for disease initiation, which then becomes self-sustaining and life-threatening. Recent studies have attributed the key distal event to excessive IFN-gamma production; however, the proximal events driving immune dysregulation have remained undefined. OBJECTIVE: We sought to investigate the role of regulatory T (Treg) cells in the pathophysiology of experimental FHL. METHODS: Because mutation in perforin is a common cause of FHL, we used an experimental FHL mouse model in which disease in perforin-deficient mice is triggered by lymphocytic choriomeningitis virus (LCMV). We assessed Treg and CD8(+) T-cell homeostasis and activation during the changing systemic conditions in the mice. In addition, human blood samples were collected and analyzed during the HLH episode. RESULTS: We found no primary Treg cell defects in perforin-deficient mice. However, Treg cell numbers collapsed after LCMV inoculation. The collapse of Treg cell numbers in LCMV-triggered perforin-deficient, but not wild-type, mice was accompanied by the combination of lower IL-2 secretion by conventional CD4(+) T cells, increased IL-2 consumption by activated CD8(+) T cells, and secretion of competitive soluble CD25. Moreover low Treg cell numbers were observed in untreated patients experiencing HLH flares. CONCLUSION: These results demonstrate that excessive CD8(+) T-cell activation rewires the IL-2 homeostatic network away from Treg cell maintenance and toward feed-forward inflammation. These results also provide a potential mechanistic pathway for the progression of infectious inflammation to persistent inflammation in patients with HLH. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailFully automated electrophoretically mediated microanalysis for CYP1A1 activity monitoring optimized by multivariate approach
Farcas, Elena ULg; Servais, Anne-Catherine ULg; Lamalle, Caroline ULg et al

in Electrophoresis (2016), 37(2), 248-255

In this study, a fully automatized in-capillary system was developed to monitor the activity of CYP1A1 in physiological conditions. Ethoxycoumarin, the selected substrate, undergoes an in-line bioreaction ... [more ▼]

In this study, a fully automatized in-capillary system was developed to monitor the activity of CYP1A1 in physiological conditions. Ethoxycoumarin, the selected substrate, undergoes an in-line bioreaction in the presence of CYP1A1 supersomes and NADPH as co-factor, giving rise to hydroxycoumarin, the product that was assayed. The optimization of the experimental conditions was supported by the application of a design of experiment, providing a better understanding of electrophoretic mixing parameters that influence the metabolic reactions. The results obtained in optimal conditions were compared not only to those achieved after off-line metabolization but also with liver microsomes. Finally, inhibition studies were conducted showing an important decrease of hydroxycoumarin formation using apigenin as CYP1A1 potent inhibitor. This study demonstrates the usefulness of our in-line system for the fully automated in vitro metabolism studies and the screening of new CYP1A1 inhibitors. [less ▲]

Detailed reference viewed: 43 (25 ULg)
Full Text
Peer Reviewed
See detailDSIMA: A testbed for the quantitative analysis of interaction models within distribution networks
Mathieu, Sébastien ULg; Louveaux, Quentin ULg; Ernst, Damien ULg et al

in Sustainable Energy, Grids and Networks (2016), 5

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in ... [more ▼]

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in which the distribution system operator, the transmission system operator, producers and retailers make their decisions based on mixed-integer linear programs. This testbed helps to highlight the characteristics of an interaction model, the benefits for the agents and eases the detection of unwanted or abusive behaviors which decreases the welfare. The testbed is implemented in Python and the optimization problems are encoded in the modeling language ZIMPL. A web interface is coupled with an instance generator using macroscopic parameters of the system such as the total power production. This testbed is, therefore, well suited to test the implemented interaction models on various scenarios and to extend the implementation to other models. Five interaction models developed with industrial partners are simulated over a year on a 75-bus test system. Simulations show that interaction models relying on active network management, as they have been developed, lead to substantial welfare even though they suffer from a lack of coordination between the DSO and the TSO. A conservative interaction model restricting grid users to an access range that is computed ahead of time to prevent any congestion, avoids shedding distributed generation but considerably restrains the amount of distributed production. [less ▲]

Detailed reference viewed: 440 (45 ULg)
Full Text
Peer Reviewed
See detailProtoporphyrin IX Functionalised AgSiO2 Core-shell Nanoparticle: Plasmonic Enhancement of Fluorescence and Singlet Oxygen Production
Lismont, Marjorie ULg; Dreesen, Laurent ULg; Heinrichs, Benoît ULg et al

in Photochemistry & Photobiology (2016), 92

Metal-enhanced processes arising from the coupling of a dye with metallic nanoparticles (NPs) have been widely reported. However, few studies have simultaneously investigated these mechanisms from the ... [more ▼]

Metal-enhanced processes arising from the coupling of a dye with metallic nanoparticles (NPs) have been widely reported. However, few studies have simultaneously investigated these mechanisms from the viewpoint of dye fluorescence and photoactivity. Herein, protoporphyrin IX (PpIX) is grafted onto the surface of silver core silica shell NPs in order to investigate the effect of silver (Ag) localized surface plasmon resonance (LSPR) on PpIX fluorescence and PpIX singlet oxygen (1O2) production. Using two Ag core sizes, we report a systematic study of these photophysical processes as a function of silica (SiO2) spacer thickness, LSPR band position and excitation wavelength. The excitation of Ag NP LSPR, which overlaps the PpIX absorption band, leads to the concomitant enhancement of PpIX fluorescence and 1O2 production independently of the Ag core size, but in a more pronounced way for larger Ag cores. These enhancements result from the increase in the PpIX excitation rate through the LSPR excitation and decrease when the distance between PpIX and Ag NPs increases. A maximum fluorescence enhancement of up to 14-fold, together with an increase in photogenerated 1O2 production of up to five times are obtained using 100 nm Ag cores coated with a 5 nm thick silica coating. [less ▲]

Detailed reference viewed: 43 (7 ULg)
Full Text
Peer Reviewed
See detailExperimental and Theoretical Study of the Reactivity of Gold Nanoparticles Towards Benzimidazole-2-ylidene Ligands
Rodríguez-Castillo, María; Lugo-Preciado, Gustavo; Laurencin, Danielle et al

in Chem. Eur. J. (2016), 22

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (deuxième partie)
Léonard, Laura ULg; Caprasse, Olivier; Dieux, Xavier et al

in Revue Critique de Jurisprudence Belge [= RCJB] (2016), (2),

Detailed reference viewed: 20 (0 ULg)
Full Text
Peer Reviewed
See detailInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke et al

in Lancet (2016)

Detailed reference viewed: 898 (15 ULg)
Full Text
Peer Reviewed
See detailThe transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.
Rambout, Xavier ULg; Detiffe, Cecile; Bruyr, Jonathan et al

in Nature Structural & Molecular Biology (2016)

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical ... [more ▼]

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical transcription factors whose previously described functions are confined to the control of mRNA synthesis. Here, we report that ERG also regulates gene expression by affecting mRNA stability and identify the molecular mechanisms underlying this function in human cells. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. Transcriptome-wide mRNA stability analysis revealed that ERG controls the degradation of a subset of mRNAs highly connected to Aurora signaling, whose decay during S phase is necessary for mitotic progression. Our data indicate that control of gene expression by mammalian transcription factors may follow a more complex scheme than previously anticipated, integrating mRNA synthesis and degradation. [less ▲]

Detailed reference viewed: 30 (6 ULg)
Full Text
Peer Reviewed
See detailCan computer vision problems benefit from structured hierarchical classification?
Hoyoux, Thomas ULg; Rodríguez-Sánchez, Antonio J.; Piater, Justus H.

in Machine Vision & Applications (2016)

Detailed reference viewed: 29 (6 ULg)
Full Text
Peer Reviewed
See detailThe spatiality of local governments in European intermediate urban regions: a methodological approach
Breuer, Christophe ULg; Halleux, Jean-Marie ULg

in Quaestiones Geographicae (2016)

Local authorities are central actors in the governance of European intermediate urban regions. In this paper, we propose a methodology to analyse the fragmentation of local authorities within 119 urban ... [more ▼]

Local authorities are central actors in the governance of European intermediate urban regions. In this paper, we propose a methodology to analyse the fragmentation of local authorities within 119 urban regions. We tested several European databases to create indicators of fragmentation and to develop a typology of fragmentation within cities. Our results show that the Eurostat Cities programme gives a consistent spatial definition of urban regions and that their fragmentation is mainly influenced by national contexts. The developed methodology is a contribution to the debate on territorial reforms and urban governance transformations. [less ▲]

Detailed reference viewed: 31 (11 ULg)
Full Text
Peer Reviewed
See detailNitrous oxide and methane seasonal variability in the epilimnion of a large tropical meromictic lake (Lake Kivu, East-Africa)
Roland, Fleur ULg; Darchambeau, François ULg; Morana, Cédric et al

in Aquatic Sciences (2016)

We report a data-set of monthly vertical profiles obtained from January 2012 to October 2013, from the surface to 70 m depth of nitrous oxide (N2O) and dissolved methane (CH4) in Lake Kivu, a large and ... [more ▼]

We report a data-set of monthly vertical profiles obtained from January 2012 to October 2013, from the surface to 70 m depth of nitrous oxide (N2O) and dissolved methane (CH4) in Lake Kivu, a large and deep meromictic tropical lake (East Africa). Vertical variations of N2O were modest, with ranges of 6--9 and 0--16 nmol L−1 in surface and bottom waters, respectively, and occasionally peaks of N2O (up to 58 nmol L−1) were observed at the oxic-anoxic interface. On the contrary, steep vertical gradients of CH4 were observed with values changing several orders of magnitude from surface (19--103 nmol L−1) to 70 m (113,000--520,000 nmol L−1). Seasonal variations of CH4 were caused by annual cycles of mixing and stratification, during the dry and rainy seasons, respectively. This mixing allowed the establishment of a thick oxic layer (maximum 65 m deep), leading to decreased CH4 concentrations (minimum of 8 nmol L−1), presumably due to bacterial CH4 oxidation. During the stratification period, the oxic mixed layer was thinner (minimum 25 m deep), and an increase of CH4 concentrations in surface waters was observed (maximum of 103 nmol L−1), probably due to a lower integrated CH4 oxidation on the water column. Lake Kivu seasonally alternated between a source and a sink for atmospheric N2O, but on an annual scale was a small source of N2O to the atmosphere (on average 0.43 \textmumol m−2 day−1), while it was a small source of CH4 to the atmosphere throughout the year (on average 86 \textmumol m−2 day−1). Vertical and seasonal variations of N2O are discussed in terms of nitrification and denitrification, although from the present data-set it is not possible to unambiguously identify the main drivers of N2O production. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailExperimental Neospora caninum infection modifies trophoblast cell populations and plasma pregnancy-associated glycoprotein 1 and 2 dynamics in pregnant dairy heifers.
Mur-Novales, R.; Serrano-Perez, B.; Garcia-Ispierto, I. et al

in Veterinary parasitology (2016), 216

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast ... [more ▼]

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast cells, are used for pregnancy diagnosis and as a marker of foetal-placental well-being, while PAG-2, produced by both mono- and binucleate trophoblast cells, may serve as an indicator of abortion risk. In prior work, natural N. caninum infection was found to modify plasma PAG-1 and PAG-2 patterns. The present study examines PAG-1 and PAG-2 dynamics and trophoblast cell populations following experimental infection with N. caninum. The study population was comprised of 17 N. caninum seronegative Holstein-Friesian heifers. On day 110 of gestation, 6 heifers were inoculated intravenously with 10(7) taquyzoites of N. canimum. Plasma samples for PAG-1 and PAG-2 determinations were collected on days 0, 7, 14, 21 and 42 post infection. During the study course, pregnancy was normally expressed in all controls while three infected heifers lost their foetuses. All heifers were euthanised on day 42 post infection and placentome samples from the 14 non-aborting heifers were collected to examine trophoblast cell populations. Plasma PAG-1 and PAG-2 concentrations in non-infected heifers increased until the day of euthanasia while non-aborting infected heifers showed a temporary fall in PAG-1 (P<0.004) and PAG-2 (P<0.002) concentrations from 7 to 14 days post infection (dpi). The two dams aborting at 14 and 21 dpi and a third dam with a mummified foetus upon euthanasia showed dramatic PAG-1 and PAG-2 reductions from 14 dpi to undetectable levels upon euthanasia. A stereological study of placentomes revealed significantly higher relative proportions of mono- (P=0.035) and binucleate (P=0.029) trophoblast cells at 42 dpi in non-infected heifers than infected non-aborting heifers. According to our findings, following experimental N. caninum infection on day 110 of gestation, non-aborting heifers showed a brief reversible drop in plasma PAG-1 and 2 concentrations two weeks later and reduced proportions of bi- and mono-nucleate trophoblast cells 42 days after infection. In aborting dams, dramatically reduced PAG levels were related to severe placental damage and a non-viable pregnancy. [less ▲]

Detailed reference viewed: 27 (8 ULg)
Full Text
Peer Reviewed
See detailMolecular detection of six (endo-) symbiotic bacteria in Belgian mosquitoes: first step towards the selection of appropriate paratransgenesis candidates
Raharimalala, Fara Nantenaina; Boukraa, Slimane ULg; Bawin, Thomas ULg et al

in Parasitology Research (2016)

Actually, the use of symbiotic bacteria is one of alternative solution to avoid vector resistance to pesticides. In Belgium, among 31 identified mosquito species, 10 were considered as potential vectors ... [more ▼]

Actually, the use of symbiotic bacteria is one of alternative solution to avoid vector resistance to pesticides. In Belgium, among 31 identified mosquito species, 10 were considered as potential vectors. Given to introduction risks of arbovirosis, the purpose of this study was to investigate the presence of symbiosis bacteria in potential mosquito vectors. Eleven species caught from 12 sites in Belgium were used: Culex pipiens s.l., Culex torrentium, Culex hortensis, Anopheles claviger, Anopheles maculipennis s.l., Anopheles plumbeus, Culiseta annulata, Ochlerotatus geniculatus, Ochlerotatus dorsalis, Aedes albopictus, and Coquillettidia richiardii. Six genera of symbiotic bacteria were screened: Wolbachia sp., Comamonas sp, Delftia sp., Pseudomonas sp., Acinetobacter sp., and Asaia sp.Atotal of 173 mosquito individuals (144 larvae and 29 adults) were used for the polymerase chain reaction screening. Wolbachia was not found in any Anopheles species nor Cx. torrentium. A total absence of Comamonas and Delftia was observed in all species. Acinetobacter, Pseudomonas, and Asaia were found in most of species with a high prevalence for Pseudomonas. These results were discussed to develop potential strategy and exploit the variable occurrence of symbiotic bacteria to focus on them to propose biological ways of mosquito control. [less ▲]

Detailed reference viewed: 39 (9 ULg)
Full Text
Peer Reviewed
See detailToward “Concessions 2.0”: articulating inclusive and exclusive management in production forests in Central Africa
Karsenty, Alain; Vermeulen, Cédric ULg

in International Forestry Review (2016), 18(S1), 13

Industrial forest concessions cover about 45 million hectares in Central Africa. This paper discusses the weaknesses of the current concession model and initiatives for helping it evolve; it then proposes ... [more ▼]

Industrial forest concessions cover about 45 million hectares in Central Africa. This paper discusses the weaknesses of the current concession model and initiatives for helping it evolve; it then proposes a new type of concession, entitled ‘Concessions 2.0’, adapted to the future challenges presented by the overlapping among the rights and modes of the harvesting of multiple resources. This proposed model is based on four features: (i) mapping and recognition of the customary territories within and around the industrial concession, (ii) timber revenue sharing indexed on the extension of the customary territories and contractual management agreements within the communities, (iii) allowance of commercial exploitation of non-timber resources by entitled claimers under the supervision and/or in association with the concessionaire, and (iv) inclusive governance for the management of overlapping rights over the concession area. [less ▲]

Detailed reference viewed: 23 (6 ULg)
Full Text
Peer Reviewed
See detailCovariance-constrained difference inversion of time-lapse electrical resistivity tomography data
Hermans, Thomas ULg; Kemna, Andreas; Nguyen, Frédéric ULg

in Geophysics (2016), 81(5), 311-322

Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active ... [more ▼]

Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active processes in shallow subsurface reservoirs. Time-lapse inversion schemes have been developed to refine inversion results, but they mostly still rely on a spatial regularization procedure based on the standard smoothness constraint. In this paper, we propose to apply a covariance-based regularization operator in the time-lapse ERT inverse problem. We first illustrate the method for surface and cross-hole ERT with two synthetic cases and compare the results with the smoothness-constrained inversion (SCI). The examples show that the covariance–constrained inversions (CCI) better image the anomaly both in terms of shape and amplitude. Although more important in low-sensitivity zones, improvements are observed everywhere in the tomograms. Those synthetic examples also show that an error made in the range or in the type of the variogram model has a limited impact on the resulting image, which still remains better than SCI. The method is then applied to cross-borehole ERT field data from a heat tracing experiment, where the comparison with direct measurements shows a strong improvement of the breakthrough curves retrieved from ERT. The proposed method could be extended to the time dimension which would allow the use of CCI in 4D inversion schemes. [less ▲]

Detailed reference viewed: 57 (15 ULg)
Full Text
Peer Reviewed
See detailKisspeptin Expression in the Human Infundibular Nucleus in Relation to Sex, Gender Identity, and Sexual Orientation.
Taziaux, Mélanie ULg; Staphorsius, Annemieke S.; Ghatei, Mohammad A. et al

in Journal of Clinical Endocrinology and Metabolism (2016), 101(6), 2380-9

CONTEXT: Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex ... [more ▼]

CONTEXT: Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex differences in kisspeptin expression have been shown in humans in adulthood, the developmental origin of this sex difference is unknown. OBJECTIVES: Our objectives were to determine the following: 1) when during development the sex difference in kisspeptin expression in the infundibular nucleus would emerge and 2) whether this sex difference is related to sexual orientation or transsexuality. DESIGN AND SETTING: Postmortem hypothalamic tissues were collected by The Netherlands Brain Bank, and sections were stained for kisspeptin by immunohistochemistry. PATIENTS: Hypothalami of 43 control subjects were categorized into three periods: infant/prepubertal (six girls, seven boys), adult (11 women, seven men), and elderly (six aged women, six aged men). Eight male-to-female (MTF) transsexuals, three HIV(+) heterosexual men, and five HIV(+) homosexual men were also analyzed. MAIN OUTCOME MEASURE: We estimated the total number of kisspeptin-immunoreactive neurons within the infundibular nucleus. RESULTS: Quantitative analysis confirmed that the human infundibular kisspeptin system exhibits a female-dominant sex difference. The number of kisspeptin neurons is significantly greater in the infant/prepubertal and elderly periods compared with the adult period. Finally, in MTF transsexuals, but not homosexual men, a female-typical kisspeptin expression was observed. CONCLUSIONS: These findings suggest that infundibular kisspeptin neurons are sensitive to circulating sex steroid hormones throughout life and that the sex reversal observed in MTF transsexuals might reflect, at least partially, an atypical brain sexual differentiation. [less ▲]

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailCapitalizing in fine milk composition for breeding and management of dairy cows
Gengler, Nicolas ULg; Soyeurt, Hélène ULg; Dehareng, Fréderic et al

in Journal of Dairy Science (2016), 99

The challenge of managing and breeding dairy cows is permanently adapting to changing production circumstances under socio-economic constraints. If managing and breeding address different timeframes of ... [more ▼]

The challenge of managing and breeding dairy cows is permanently adapting to changing production circumstances under socio-economic constraints. If managing and breeding address different timeframes of action, both need relevant phenotypes that allow for precise monitoring of the status of the cows, and their health, behavior, and well-being as well as their environmental impact and the quality of their products (i.e., milk and subsequently dairy products). Milk composition has been identified as an important source of information because it could reflect, at least partially, all these elements. Major conventional milk components such as fat, protein, urea, and lactose contents are routinely predicted by mid-infrared (MIR) spectrometry and have been widely used for these purposes. But, milk composition is much more complex and other nonconventional milk components, potentially predicted by MIR, might be informative. Such new milk-based phenotypes should be considered given that they are cheap, rapidly obtained, usable on a large scale, robust, and reliable. In a first approach, new phenotypes can be predicted from MIR spectra using techniques based on classical prediction equations. This method was used successfully for many novel traits (e.g., fatty acids, lactoferrin, minerals, milk technological properties, citrate) that can be then useful for management and breeding purposes. An innovation was to consider the longitudinal nature of the relationship between the trait of interest and the MIR spectra (e.g., to predict methane from MIR). By avoiding intermediate steps, prediction errors can be minimized when traits of interest (e.g., methane, energy balance, ketosis) are predicted directly from MIR spectra. In a second approach, research is ongoing to detect and exploit patterns in an innovative manner, by comparing observed with expected MIR spectra directly (e.g., pregnancy). All of these traits can then be used to define best practices, adjust feeding and health management, improve animal welfare, improve milk quality, and mitigate environmental impact. Under the condition that MIR data are available on a large scale, phenotypes for these traits will allow genetic and genomic evaluations. Introduction of novel traits into the breeding objectives will need additional research to clarify socio-economic weights and genetic correlations with other traits of interest. [less ▲]

Detailed reference viewed: 39 (18 ULg)
Full Text
Peer Reviewed
See detailZooarchaeological study of an Upper Palaeolithic site with mammoth remains, Pushkari Ieexcavation VII (Chernigov oblast, Ukraine)
Demay, Laëtitia ULg; Péan, Stéphane; Belyaeva, Valentina I. et al

in Quaternary International (2016)

The Pushkari archaeological complex is one of the few sites which shows human occupations related to the first part of the Upper Pleniglacial. Pushkari I furnished rich archaeological material. Study of ... [more ▼]

The Pushkari archaeological complex is one of the few sites which shows human occupations related to the first part of the Upper Pleniglacial. Pushkari I furnished rich archaeological material. Study of the lithic industry identified a facies of Gravettian with epigravettian features, called Pushkarian. In order to figure out acquisition and treatment modalities of large mammals, and to test the hypothesis of the use of woolly mammoth as a source of food and building material, we conducted a zooarchaeological study of the faunal remains from excavation VII of Pushkari I. The faunal spectrum is made of Mammuthus primigenius, the predominant species, Equus sp., R. tarandus, Canis lupus and Vulpes vulpes/Alopex lagopus. Taphonomic study suggests that some bone remains of mammoth lay in open-air for a long time before they were buried while bones of carnivores and other bones of mammoth were quickly buried. All the assemblage was affected by acid sandy deposits. Phenomena of freeze-thaw action were observed, but the archaeological layer was little disturbed. Mammoths came regularly on the promontory. The skeletal preservation shows that they died there. The mortality profile with a majority of adults combined with a palethnographic interpretation suggests that they were slaughtered and butchered by human groups. Tusks were stored. The spatial distribution indicates a campsite, which corresponds to recurrent short-termed occupations on the promontory by human groups. This site is a strategic place to collect flint to make weapons, to find dry mammoth bones, and to hunt and butcher mammoths. This study provides new data to understand the particular status of the woolly mammoth for the Upper Pleniglacial human groups in the Russo-Ukrainian plain. [less ▲]

Detailed reference viewed: 33 (4 ULg)
Full Text
Peer Reviewed
See detailNa2FePO4F/multi-walled carbon nanotubes for lithium-ion batteries: Operando Mössbauer study of spray-dried composites
Brisbois, Magali; Caes, Sébastien ULg; Sougrati, M.T. et al

in Solar Energy Materials & Solar Cells (2016), 148

In order to favor electronic conductivity in sodium iron fluorophosphate electrodes for lithium- or sodium-ion batteries, composites of Na2FePO4F with multi-walled carbon nanotubes (CNTs) were prepared by ... [more ▼]

In order to favor electronic conductivity in sodium iron fluorophosphate electrodes for lithium- or sodium-ion batteries, composites of Na2FePO4F with multi-walled carbon nanotubes (CNTs) were prepared by pilot-scale spray drying. Addition of multi-walled CNTs in the solution results in an excellent dispersion of the CNTs within the volume of Na2FePO4F and not only at the surface of the particles. Following a heat treatment at 600°C in argon in order to reach crystallization, X-ray diffraction and ex situ Mössbauer spectroscopy revealed the presence of significant amounts of Fe(III) and maghemite (γ-Fe2O3) in the powder. However, Na2FePO4F/CNTs composites exhibit good electrochemical performance when cycling against lithium, with a discharge capacity of 104mAhg-1 at C/10 rate and 90mAhg-1 at 1C rate. Therefore, operando 57Fe transmission Mössbauer spectroscopy analyses were carried out in order to investigate the evolution of the iron oxidation state during cycling. During the first discharge, all the Fe(III) is reduced to Fe(II), explaining the good electrochemical performance. [less ▲]

Detailed reference viewed: 80 (18 ULg)
Full Text
Peer Reviewed
See detailTree light capture and spatial variability of understory light increase with species mixing and tree size heterogeneity
Ligot, Gauthier ULg; Ameztegui, Aitor; Courbaud, Benoît et al

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2016)

Mixed and multi-layered forest ecosystems are sometimes more productive than monospecific and single-layered ones. It has been suggested that trees of different species and sizes occupy complementary ... [more ▼]

Mixed and multi-layered forest ecosystems are sometimes more productive than monospecific and single-layered ones. It has been suggested that trees of different species and sizes occupy complementary positions in space which would act as a mechanism to increase canopy light interception and wood production. However, greater canopy light interception reduces the average amount and variability of transmitted radiation offering fewer opportunities for all species to regenerate and to maintain forest heterogeneity in the long-run. We investigated whether increasing overstory heterogeneity indeed results in greater canopy light interception and lower variability in transmittance. We modeled the three-dimensional structure of forest stands with 3 typical forest structures, 10 mixtures of four tree species, and 3 different basal areas. We used the forest light interception model SAMSARALIGHT and performed three-way analyses of covariance to analyze the effects of the three varied components of forest heterogeneity. We found no evidence that increasing heterogeneity increases canopy light interception. In contrast, homogeneous stands intercept more light than heterogeneous stands. Variability in transmittance increased in some cases with compositional heterogeneity and, to a lesser extent, with tree size inequalities. The advantage of heterogeneous forests is in opportunities for natural regeneration rather than in opportunities to enhance canopy light interception. [less ▲]

Detailed reference viewed: 122 (7 ULg)
Full Text
Peer Reviewed
See detailExperimental Comparative Study on Lithium Chloride and Calcium Chloride Desiccants
Bouzenada, Saliha ULg; Kaabi, A. N.; Fraikin, Laurent ULg et al

in Procedia Computer Science (2016), 83(718-725),

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailDes abeilles en fagnes, oui, mais pas de ruches
Fagot, Jean ULg

in Hautes Fagnes (2016), 82(2), 18-23

Bien souvent, la question se pose de savoir si l’abeille domestique (Apis mellifera L., 1758), notre mouche à miel, est de bonne compagnie et peut côtoyer sans inconvénients les autres abeilles de chez ... [more ▼]

Bien souvent, la question se pose de savoir si l’abeille domestique (Apis mellifera L., 1758), notre mouche à miel, est de bonne compagnie et peut côtoyer sans inconvénients les autres abeilles de chez nous que l’on regroupe sous le vocable d’« abeilles solitaires » ou d’« abeilles sauvages ». La question se précise lorsqu’un apiculteur demande à placer des ruches en réserve naturelle et notamment dans les fagnes, fagnes que nous arpentons sans trop prêter attention à ce peuple discret et tellement utile. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailOrigin of dc voltage in type II superconducting flux pumps: field, field rate of change, and current density dependence of resistivity
Geng, J.; Matsuda, K.; Fu, L. et al

in Journal of Physics : D Applied Physics (2016), 49(11), 1101

Superconducting flux pumps are the kind of devices which can generate direct current into superconducting circuit using external magnetic field. The key point is how to induce a dc voltage across the ... [more ▼]

Superconducting flux pumps are the kind of devices which can generate direct current into superconducting circuit using external magnetic field. The key point is how to induce a dc voltage across the superconducting load by ac fields. Giaever (1966 IEEE Spectr . 3 [http://dx.doi.org/10.1109/MSPEC.1966.5217702] 117 ) pointed out flux motion in superconductors will induce a dc voltage, and demonstrated a rectifier model which depended on breaking superconductivity. van de Klundert et al (1981 Cryogenics 21 [http://dx.doi.org/10.1016/0011-2275(81)90195-8] 195, 267 ) in their review(s) described various configurations for flux pumps all of which relied on inducing the normal state in at least part of the superconductor. In this letter, following their work, we reveal that a variation in the resistivity of type II superconductors is sufficient to induce a dc voltage in flux pumps and it is not necessary to break superconductivity. This variation in resistivity is due to the fact that flux flow is influenced by current density, field intensity, and field rate of change. We propose a general circuit analogy for travelling wave flux pumps, and provide a mathematical analysis to explain the dc voltage. Several existing superconducting flux pumps which rely on the use of a travelling magnetic wave can be explained using the analysis enclosed. This work can also throw light on the design and optimization of flux pumps. [less ▲]

Detailed reference viewed: 20 (6 ULg)
Full Text
Peer Reviewed
See detailDu meurtre commis pour faciliter le vol : considérations critiques
Jacques, Elodie ULg

in Revue de Droit Pénal et de Criminologie (2016)

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailEdaphic niches of metallophytes from southeastern Democratic Republic of Congo: implications for post-mining restoration
Boisson, Sylvain ULg; Monty, Arnaud ULg; Lebrun, Julie et al

in Journal for Nature Conservation (2016)

In southeastern D. R. Congo, about 550 metallophytes grow on soils with high copper and cobalt concentrations, 57 of which are endemics to these metalliferous environments. About 70% of those endemics are ... [more ▼]

In southeastern D. R. Congo, about 550 metallophytes grow on soils with high copper and cobalt concentrations, 57 of which are endemics to these metalliferous environments. About 70% of those endemics are considered threatened by destruction of habitats through mining activities. To provide guidelines for future restoration programs, the edaphic ecological niches of eight copper endemics were studied using a pragmatic sampling method adapted for urgent conservation needs. Niches were modelled using violin plot along Cu, Co and C:N gradients representing the two main independent edaphic gradients among nine edaphic variables (C, N, C:N, K, P, pH, Co, Cu, and Mn). Copper endemics presented distinct edaphic niches along the copper and cobalt gradients, but differentiation was lower along the C:N gradient. In addition, edaphic elements presented covariations among them and metalliferous soils had higher nutrient and element content compared to the non-metalliferous soils of the region dominated by the Miombo woodland. The complexity of the soil composition and the edaphic niches of copper endemics revealed an important challenge in the implementation of the species conservation and the habitat restoration strategies of post-mining sites. [less ▲]

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailUn volvulus du sigmoïde: le rôle du radiologue
DEQUIEDT, C; MILICEVIC, Mladen ULg

in Revue Médicale de Liège (2016), 71(5), 252-255

Le volvulus du sigmoïde est la troisième cause d'obstruction colique après le carcinome et la diverticulite (1) dans nos contrées et deviendra une cause encore plus importante dans le futur étant donné sa ... [more ▼]

Le volvulus du sigmoïde est la troisième cause d'obstruction colique après le carcinome et la diverticulite (1) dans nos contrées et deviendra une cause encore plus importante dans le futur étant donné sa prévalence chez les personnes âgées et/ou institutionnalisées. De plus, c’est la première cause d’obstruction intestinale chez la femme enceinte. Étant donné sa clinique peu spécifique, le clinicien doit faire appel aux examens complémentaires et surtout radiographiques pour le diagnostic (2). Le rôle du radiologue est donc primordial dans le diagnostic et pour certains cas dans la thérapeutique du volvulus du sigmoïde. Ceci n’est pas anodin étant donné la morbi/mortalité importante de cette pathologie. Nous vous rapportons ici le cas typique d’un patient de 60 ans se présentant aux urgences pour des vomissements et le ballonnement depuis quelques jours. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailScreening for GPR101 defects in pediatric pituitary corticotropinomas.
Trivellin, Giampaolo; Correa, Ricardo R.; Batsis, Maria et al

in Endocrine-related cancer (2016), 23(5), 357-365

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been ... [more ▼]

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage of cases are still unknown. We investigated the orphan G protein-coupled receptor GPR101, a gene known to be involved in somatotropinomas, for its possible involvement in corticotropinomas. We performed GPR101 sequencing, expression analyses by RT-qPCR and immunostaining, and functional studies (cell proliferation, pituitary hormones secretion, and cAMP measurement) in a series of patients with sporadic CD secondary to ACTH-secreting adenomas in whom we had peripheral and tumor DNA (N=36). No increased GPR101 expression was observed in tumors compared to normal pituitary (NP) tissues, nor did we find a correlation between GPR101 and ACTH expression levels. Sequence analysis revealed a very rare germline heterozygous GPR101 variant (p.G31S) in one patient with CD. Overexpression of the p.G31S variant did not lead to increased growth and proliferation, although modest effects on cAMP signaling were seen. GPR101 is not overexpressed in ACTH-secreting tumors compared to NPs. A rare germline GPR101 variant was found in one patient with CD but in vitro studies did not support a consistent pathogenic effect. GPR101 is unlikely to be involved in the pathogenesis of CD. [less ▲]

Detailed reference viewed: 19 (9 ULg)
Peer Reviewed
See detailConvective drying behavior of sawdust-sludge mixtures in a fixed bed
Li, Jie; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Drying Technology (2016), 34(4), 395-402

Detailed reference viewed: 32 (9 ULg)
Full Text
Peer Reviewed
See detailPhenolic profile, antibacterial and cytotoxic properties of second grade date extract from Tunisian cultivars (Phoenix dactylifera L.)
Kchaou, Wissal; Abbès, Fatma; Ben Mansour, Riadh et al

in Food Chemistry (2016), (194), 1048-1055

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic ... [more ▼]

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic content was analyzed by HPLC. Antimicrobial activity was evaluated by the agar disk diffusion method, and in vitro cytotoxic activity was examined by cell proliferation assay. The results revealed that second grade dates presented three benzoic acids, five cinnamic acids and two flavonoids, with the predominance of q-coumaric acid (1998.80 lg/100 g). The antimicrobial activities showed that the date extracts were active against Gram (+) and Gram (-) bacteria, showing marked activity against Escherichia coli with an inhibition zone of 25 mm. Cytotoxicity assays showed that the date extracts were able to inhibit the proliferation of HeLa cell lines. The results confirmed that the date extracts were rich in biologically active compounds that are highly valued in the functional food and nutraceutical industries. [less ▲]

Detailed reference viewed: 31 (6 ULg)
Full Text
Peer Reviewed
See detailSurfactant-assisted ultrasonic spray pyrolysis of hematite mesoporous thin films
Henrist, Catherine ULg; Toussaint, Caroline ULg; De Vroede, Jordan et al

in Microporous and Mesoporous Materials (2016), 221

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal ... [more ▼]

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal goethiteto-hematite phase transition. In a previous work, it has been reported that with very careful calcination steps, it is possible to prepare mesoporous hematite films with the spin-coating technique. However, with less conventional techniques such as surfactant-assisted ultrasonic spray pyrolysis, the deposition usually leads to non-porous oxide films or to films with interstitial porosity. In this work, we demonstrate for the first time the proof-of-concept of block-copolymer templating of hematite thin films by the ultrasonic spray pyrolysis technique. Despite the fast thermal decomposition during spray deposition, a regular, monodisperse packing of spherical pores is observed after deposition on pre-heated substrates (250 C) and after a careful post-annealing step at 470 C. Moreover, with the use of a silica scaffold, we successfully preserved porosity up to a temperature as high as 800 C. These films are highly crystalline and they are composed by randomly oriented nanocrystallites with sizes as small as 25 nm. Furthermore, we show that the crystallization evolution with temperature is influenced by the presence of the templating agent and also by the preparation technique. [less ▲]

Detailed reference viewed: 55 (15 ULg)
Full Text
Peer Reviewed
See detailCore cross-linked micelles of polyphosphoester containing amphiphilic block copolymers as drug nanocarriers
Ergül, Zeynep ULg; Vanslambrouck, Stéphanie; Cajot, Sébastien et al

in RSC Advances (2016), 6(48), 42081-42088

Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the ... [more ▼]

Poly(ethylene oxide)-b-polyphosphoester amphiphilic block copolymers are known to self-assemble into polymer micelles when dissolved into water. This work aims at reporting on the improvement of the stability of the micelles at high dilution by crosslinking the hydrophobic polyphosphoester micellar core. Typically, an unsaturated alkene side-chain was introduced on the cyclic phosphate monomer according to a one-step reaction followed by its organocatalyzed polymerization initiated by a poly(ethylene oxide) macroinitiator. This strategy avoids the use of any organometallic compounds in order to facilitate the purification and meet the stringent requirements of biomedical applications. After self-assembly into water, the micelles were cross-linked by simple UV irradiation. These cross-linked micelles have then been loaded by doxorubicin to evaluate their potential as drug nanocarriers and monitor the impact of crosslinking on the release profile. [less ▲]

Detailed reference viewed: 33 (12 ULg)
Full Text
Peer Reviewed
See detailMaximum entropy properties of discrete-time first-order stable spline kernel
Chen, Tianshi; Ardeshiri, Tohid; Carli, Francesca Paola ULg et al

in Automatica (2016), 66

Detailed reference viewed: 51 (2 ULg)
Full Text
Peer Reviewed
See detailMagneto-optical trapping of iron atoms
Crauwels, Justine ULg; Huet, Nicolas ULg; Krins, Stéphanie ULg et al

in Belgian Physical Society Magazine (2016), 1

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailImprovement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Hamaïdia, Malik ULg; Staumont, Bernard ULg; DUYSINX, Bernard ULg et al

in Current Topics in Medicinal Chemistry (2016), 16

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor ... [more ▼]

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators. [less ▲]

Detailed reference viewed: 80 (28 ULg)
Full Text
Peer Reviewed
See detailDulaglutide (LY-2189265) for the treatment of type 2 diabetes.
Scheen, André ULg

in Expert review of clinical pharmacology (2016), 9(3), 385-99

Dulaglutide is a new once-weekly glucagon-like peptide-1 receptor agonist for the management of hyperglycemia in adult patients with type 2 diabetes. It stimulates dose-dependent insulin secretion and ... [more ▼]

Dulaglutide is a new once-weekly glucagon-like peptide-1 receptor agonist for the management of hyperglycemia in adult patients with type 2 diabetes. It stimulates dose-dependent insulin secretion and reduces glucagon secretion, both in a glucose-dependent manner. Efficacy on blood glucose control and safety were demonstrated in the large AWARD program in type 2 diabetic patients treated with diet, metformin, dual oral therapy or insulin lispro with or without metformin, confirming findings of pilot studies in Caucasian patients and data in Japanese patients. Dulaglutide 1.5 mg once weekly was superior to metformin, sitagliptin, insulin glargine and exenatide twice daily, and non-inferior to liraglutide 1.8 mg once daily regarding the reduction in glycated hemoglobin. A modest but significant weight loss was consistently observed. Most frequent adverse events were transient and generally mild gastrointestinal disturbances. Clinical outcomes of dulaglutide will not be known until the large prospective cardiovascular outcome trial REWIND is complete. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailMiddle Miocene climate and vegetation models and their validation with proxy data
Henrot, Alexandra-Jane ULg; Utescher, T.; Erdei, B. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2016)

The Miocene is a relatively recent epoch of the Earth's history with warmer climate than today, particularly during the middle Miocene Climatic Optimum (MMCO, approximately 17-15Ma). Although the cause of ... [more ▼]

The Miocene is a relatively recent epoch of the Earth's history with warmer climate than today, particularly during the middle Miocene Climatic Optimum (MMCO, approximately 17-15Ma). Although the cause of the warming is probably not only attributable to CO2, but also to changes in orography and configuration of ocean gateways, this time interval represents an ideal case study to test the ability of climate models to simulate warm climates comparable to those that the Earth may experience in the near future. However, even with higher than present-day CO2 concentrations, the MMCO warming inferred from terrestrial proxy data has been difficult to reproduce in climate models.Since fossil flora do not provide direct information on climate, but on flora and vegetation, climate model results are generally compared to climate reconstructions obtained from the fossil flora. In this study, we apply an alternative method by simulating palaeovegetation from the outputs of the climate model, using a dynamic vegetation model. Model vegetation reconstruction can then be compared to the vegetation cover indicated by the fossil flora record at the various localities, provided that a common classification of plant functional types (PFTs) is used for the data and the model. Here, we reconstruct the vegetation of the middle Miocene with the global dynamic vegetation model CARAIB, using the climatologies derived from five atmospheric general circulation models. The reliability of the simulations is examined on a presence/absence basis of PFTs by comparison of vegetation reconstructions to palaeoflora data recorded in the Northern Hemisphere and the Tropics.This comparison provides an overall agreement around 60% between model and data, when all sites and tree types are considered. Three model simulations out of five show to be better at predicting the absence than the presence. The presence of warm-temperate mixed forests in the middle latitudes, dominated by broadleaved deciduous warm temperate and subtropical trees is generally well reproduced in CARAIB simulations. However, poor agreement is obtained for the presence of tropical PFTs out of the Tropics and for warm PFTs at latitudes northward of 50°N, where climate models remain too cold to produce assemblages of trees consistent with the data. Nevertheless, the model-data comparison performed here highlights several mismatches that could result not only from missing feedbacks in the climate simulations, but also from the data. The results of the likelihood analysis on presence/absence of PFTs illustrate the uncertainties in the PFT classification of the Neogene floral records. The coexistence of some PFTs in the palaeovegetation data is impossible to reproduce in the vegetation model simulations because of the climatic definition of the modern PFTs. This result indicates either a bias in the identification of modern analogues for fossil plant taxa, or a possible evolution of environmental requirements of certain plants. © 2016 Elsevier B.V. [less ▲]

Detailed reference viewed: 16 (7 ULg)
Full Text
Peer Reviewed
See detailInsecticidal activity of Lavandula angustifolia Mill. against the pea aphid Acyrtosiphum pisum
Attia, Sabrine; Lognay, Georges ULg; Heuskin, Stéphanie ULg et al

in Journal of Entomology and Zoology Studies (2016), 4(1), 118-122

The essential oil of Lavandula angustifolia was investigated for its biocide activity against Acyrtosiphum pisum by fumigation. The oil was characterised by GC-MS revealing that linalool was the most ... [more ▼]

The essential oil of Lavandula angustifolia was investigated for its biocide activity against Acyrtosiphum pisum by fumigation. The oil was characterised by GC-MS revealing that linalool was the most abundant component (38.57%), followed by linalyl acetate (29.95%), 1,8-cineole (13,66%), camphor (13,13%), -pinene (3,14%) and terpinene-4-ol (1,54%). The Mortality was measured upon treatment with oil concentrations ranging from 5 to 25 µl.l-1 of air. The mortality of aphids increased with oil concentration and LC50 values were determined to be 11.2 µl.l-1 of air. The full mixture was also prepared and toxicity was compared with individual constituents. The results showed that the presence of all constituents were necessary to equal the toxicity of the natural oils L. angustifolia oil can provide valuable pesticide activity with significantly lower LC50 values [less ▲]

Detailed reference viewed: 46 (8 ULg)
Full Text
Peer Reviewed
See detailRugose corals across the Devonian-Carboniferous boundary in NW Turkey
Denayer, Julien ULg

in Acta Palaeontologica Polonica (2016), 61(1), 51-70

Detailed reference viewed: 35 (7 ULg)
Full Text
Peer Reviewed
See detailIdentifying mismatch between urban travel demand and transport network services using GPS data: A case study in the fast growing Chinese city of Harbin
Cui, JianXun; Liu, Feng; Hu, Jia et al

in Neurocomputing (2016), 181

The world's urban population growth and economic development have led to the reshaping of metropolitan space layouts among residential, employment and shopping locations, generating growing mismatch ... [more ▼]

The world's urban population growth and economic development have led to the reshaping of metropolitan space layouts among residential, employment and shopping locations, generating growing mismatch between travel demand and transport services. A reliable method to accurately analyze mobility demand and underlying transport network systems and to identify areas with serious mismatch problems is important for the design of effective policy measures. In this paper, we make use of the wide deployment of GPS devices in vehicles in many cities today, to develop such a method. This approach is developed using GPS data collected from all taxis operating in the Chinese city of Harbin between July and September in 2013. It consists of four major steps. First, city-wide mobility patterns are modeled based on GPS trajectories. This model captures a set of key traffic characteristics for each pair of regions in the entire urban network, including travel demand, travel speed and route directness of travel paths. From this model, a set of indicators is then built to measure the road transport performance between the regions, and the areas with serious mismatch problems are subsequently pinpointed. Finally, the identified problematic regions are further examined and specific transport problems are analyzed. By applying the proposed method to the city of Harbin, the potential and effectiveness of this method are demonstrated. Moreover, with more and more urban vehicles being equipped with GPS devices, the designed method can be easily transferred to other cities, thus paving a way for the adoption of the presented approach for an up-to-date and spatial-temporal sensitive road network analysis approach that supports the establishment of a more sustainable urban transport system. [less ▲]

Detailed reference viewed: 29 (2 ULg)
Full Text
Peer Reviewed
See detail"Translating Multilayered Sensory Experience"
Bada, Valérie ULg; Pagnoulle, Christine ULg

in Palimpsestes (2016)

The powerful impact of the plays by African American playwright August Wilson largely relies on the way his words appeal to the senses, whether explicitly by calling upon the characters’ sensory ... [more ▼]

The powerful impact of the plays by African American playwright August Wilson largely relies on the way his words appeal to the senses, whether explicitly by calling upon the characters’ sensory experience or more indirectly through his use of syntactic rhythm, or indeed his specific modulation of AAVE. This article describes how the translators tried to create a French idiom that induces the same sensory impact on an audience and, at the same time, reflects the multilayered referentiality of the text. [less ▲]

Detailed reference viewed: 23 (10 ULg)
Full Text
Peer Reviewed
See detailEfficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Bruyère, Olivier ULg; Altman, R.D.; Reginster, Jean-Yves ULg

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 12-17

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) including glucosamine sulfate (GS) and chondroitin sulfate (CS) as first-line therapy for knee osteoarthritis (OA). Numerous studies are published on the use of SYSADOAs in OA; however, the efficacy of this class is still called into question largely due to the regulatory status, labeling and availability of these medications which differ substantially across the world. Examination of the evidence for the prescription patented crystalline GS (pCGS) formulation at a dose of 1500 mg once-daily demonstrates superiority overother GS and glucosamine hydrochloride (GH) formulations and dosage regimens. Thus, the ESCEO task force advocates differentiation of prescription pCGS over other glucosamine preparations. Long-term clinical trials andreal-life studies show that pCGS may delay joint structural changes, suggesting potential benefit beyond symptom control when used early in the management of knee OA. Real-life pharmacoeconomic studies demonstrate a long-term reduction in the need for additional pain analgesia and non-steroidal anti-inflammatory drugs (NSAIDs) with pCGS, with a significant reduction of over 50% in costs associated with medications, healthcare consultations and examinations over 12 months. Furthermore, treatment with pCGS for at least 12 months leads to a reduction in the need for total joint replacement for at least 5 years following treatment cessation. Thus, pCGS(1500 mg od) is a logical choice to maximize clinical benefit in OA patients, with demonstrated medium-term control of pain and lasting impact on disease progression. [less ▲]

Detailed reference viewed: 22 (7 ULg)
Full Text
Peer Reviewed
See detailMyoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer
Fahmy, Karim ULg; Gonzalez, Arnaud; Arafa, Mohammad et al

in International Journal of Cancer = Journal International du Cancer (2016), 138

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas ... [more ▼]

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis. However, the function of myoferlin in pancreas adenocarcinoma has not been reported. In other cell types, myoferlin is involved in several key plasma membrane processes such as fusion, repair, endocytosis and tyrosine kinase receptor activity. In this study, we showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. In addition to be smaller, the tumors formed by the myoferlin-silenced cells showed a marked absence of functional blood vessels. We further demonstrated that this effect was due, at least in part, to an inhibition of VEGFA secretion by BxPC-3 myoferlin-silenced cells. Using immunofluorescence and electron microscopy, we linked the decreased VEGFA secretion to an impairment of VEGFA exocytosis. The clinical relevance of our results was further strengthened by a significant correlation between myoferlin expression in a series of human pancreatic malignant lesions and their angiogenic status evaluated by the determination of the blood vessel density. [less ▲]

Detailed reference viewed: 101 (29 ULg)
Full Text
Peer Reviewed
See detailNewt life after fish introduction: extirpation of paedomorphosis in a mountain fish lake and newt use of satellite pools
Denoël, Mathieu ULg; Scime, Patrick; Zambelli, Nicola

in Current Zoology (2016), 62(1), 61-69

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context ... [more ▼]

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context, we determined whether small wetlands, such as pools surrounding fished and fishless lakes, could sustain paedomorphic and metamorphic newts. To this end, we surveyed lakes known historically to sustain Alpine newts (Ichthyosaura alpestris) as well as 35 nearby pools. On the basis of the published records, the only known population exhibiting paedomorphosis in the Swiss Alps was found to be extirpated by salmonid introductions. However, the metamorphs persisted in peripheral pools, paedomorphosis was discovered at a new locality, and overwintering larvae were still present in one of the lakes. These results show the importance of conserving varied aquatic habitats such as pools in mountainous environments where the main resources can become unsuitable for amphibians because of fish introductions. Pools may also function as reservoirs in maintaining newt populations until programs to remove fish from lakes can be carried out. It is not known if paedomorphs could reappear after fish removal. However, the combined resilience of amphibians after fish removal and the genetic basis for paedomorphosis highlighted in other taxa by previous studies suggest that there is the potential to maintain this intraspecific case of diversity even after its disappearance. [less ▲]

Detailed reference viewed: 213 (27 ULg)
Full Text
Peer Reviewed
See detailPrecision medicine: The future in diabetes care?
Scheen, André ULg

in Diabetes Research & Clinical Practice (2016), 117

Personalized medicine aims at better targeting therapeutic intervention to the individual to maximize benefit and minimize harm. Type 2 diabetes (T2D) is a heterogeneous disease from a genetic ... [more ▼]

Personalized medicine aims at better targeting therapeutic intervention to the individual to maximize benefit and minimize harm. Type 2 diabetes (T2D) is a heterogeneous disease from a genetic, pathophysiological and clinical point of view. Thus, the response to any antidiabetic medication may considerably vary between individuals. Numerous glucose-lowering agents, with different mechanisms of action, have been developed, a diversified armamentarium that offers the possibility of a patient-centred therapeutic approach. In the current clinical practice, a personalized approach is only based upon phenotype, taking into account patient and disease individual characteristics. If this approach may help increase both efficacy and safety outcomes, there remains considerable room for improvement. In recent years, many efforts were taken to identify genetic and genotype SNP's (Single Nucleotide Polymorphism's) variants that influence the pharmacokinetics, pharmacodynamics, and ultimately the therapeutic response of oral glucose-lowering drugs. This approach mainly concerns metformin, sulphonylureas, meglitinides and thiazolidinediones, with only scarce data concerning gliptins and gliflozins yet. However, the contribution of pharmacogenetics and pharmacogenomics to personalized therapy still needs to mature greatly before routine clinical implementation is possible. This review discusses both opportunities and challenges of precision medicine and how this new paradigm may lead to a better individualized treatment of T2D. [less ▲]

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailLes rhétoriques du peuple
Goin, Emilie ULg; Provenzano, François ULg

in Exercices de rhétorique (2016), 7

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailEdition critique et traduction de l'Abrégé d'art militaire de Végèce
Famerie, Etienne ULg

in Revue Internationale des Droits de l'Antiquité (2016), 62

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailGlucose Control in the ICU: A Continuing Story.
Preiser, Jean-Charles; Chase, J. Geoffrey; Hovorka, Roman et al

in Journal of diabetes science and technology (2016)

In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing ... [more ▼]

In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing authorities and to enable comparisons across studies and devices. Adequately powered, good quality, randomized, controlled studies are needed to assess the impact of different CGM devices on the quality of glucose control, workload, and costs. The additional effects of continuing glucose control on the general floor after the ICU stay also need to be investigated. Current algorithms need to be adapted and validated for CGM, including effects on glucose variability and workload. Improved collaboration within the industry needs to be encouraged because no single company produces all the necessary components for an automated closed-loop system. Combining glucose measurement with measurement of other variables in 1 sensor may help make this approach more financially viable. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detailA pilot double-blind, randomized, placebo-controlled trial of the efficacy of trace elements in the treatment of endometriosis-related pain: study design and methodology
OBERWEIS, Didier; MANDELENAT, Patrick; Nisolle, Michelle ULg

in Nutrition and Dietary Supplements (2016), 8

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various ... [more ▼]

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various distressing symptoms, particularly pelvic pain, which adversely affect patients’ quality of life. It is an estrogen-dependent disease. There is evidence both in animals and in humans that metal ions can activate the estrogen receptors. They are defined as a variety of xenoestrogens, called metalloestrogens, which could act as endocrine disruptors. Therefore, it could be considered to act on this gynecological disorder using food supplements containing trace elements (ie, nutripuncture). The assumption is that they could modulate estrogen receptors and thus influence the tropism and the survival of cells involved in endometriosis. By a modulation of the antioxidant system, they might also interact with various parameters influencing tissue biochemistry. The objective of this article is to describe and discuss the design and methodology of an ongoing double-blind, randomized, placebo-controlled study aiming to evaluate the efficacy of metal trace elements on the reduction of pain and improvement of quality of life, in patients with a revised American Fertility Society Score Stages II–IV endometriosis, combined or not with adenomyosis, during a treatment period of 4 months. Trace elements or placebo is proposed in the absence of any other treatment or as an add-on to current therapies, such as sexual hormones, nonsteroidal anti-inflammatory drugs, and surgery. A placebo run-in period of one menstrual cycle or 30 days for women in amenorrhea has been scheduled to eliminate the patients who are responding too much to the placebo. After a 1:1 ratio randomization on Day 0, the treatment with trace elements or placebo will last for 4 monts (120 days). [less ▲]

Detailed reference viewed: 127 (3 ULg)
Full Text
Peer Reviewed
See detailDementia-specific quality of life instruments: a conceptual analysis
Missotten, Pierre ULg; Dupuis, Gilles; Adam, Stéphane ULg

in International Psychogeriatrics (2016), 28(8), 1245-1262

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the ... [more ▼]

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the conceptual frameworks of the dementia-specific QoL instruments, to identify their evolution over time and to provide elements of reflection on the QoL concept in dementia and its evaluation. Method: An electronic search was conducted on PsycINFO and MEDLINE databases, from January 1985 to June 2015 using a combination of key words that include quality of life, dementia and review. Result: The analysis of the conceptual frameworks of the eighteen selected dementia-specific QoL tools shows a great diversity in: (1) the QoL definitions (e.g. health-related QoL definitions, QoL definitions based on Lawton’s work or similar to this latter); (2) the theoretical QoL models (e.g. Lawton’ work and modified Lawton, adaptation, personhood); (3) the domains and dimensions; (4) the way to construct the instrument (e.g. development based on literature, opinion of the experts) and (5) the items’ formulation (e.g. use of criterion of intensity or frequency). Conclusion: There are different conceptual frameworks in the dementia-specific QoL measures with improvements over time (e.g. inclusion of interesting concepts such as adaptation, taking into account the views of patients themselves). Each of the conceptual parameters (definitions, models, domains and dimensions) is discussed to identify the scales that are conceptually the strongest. Through their review, recommendations for future instrument refinement and development are discussed and a new QoL definition is proposed. [less ▲]

Detailed reference viewed: 35 (8 ULg)
Full Text
Peer Reviewed
See detailFrom "an enzyme able to destroy penicillin" to Carbapenemases: 70 Years of Beta-lactamase Misbehaviour
Frère, Jean-Marie ULg; Sauvage, Eric ULg; Kerff, Frederic ULg

in Current drug targets (2016)

As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They ... [more ▼]

As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the beta-lactam ring. Later, an enzyme mediated by an R-factor was isolated from Enterobacteriaceae. Methicillin and cephalosporins, both very poor substrates of the S. aureus enzyme, were found to be sensitive to this new enzyme. Third generation cephalosporins appeared to solve the problem, but further enzymes were selected that exhibited extended spectra and could for instance hydrolyze cefotaxime and/or ceftazidime. The discovery of carbapenems constituted a major advance for our antimicrobial arsenal: they inactivated most of the essential penicillin binding proteins effectively and escaped the activity of nearly all known beta-lactamases. However, the metallo-beta-lactamases, which had not been recognised as a major danger before 1990, were found to act as effective carbapenemases and started to spread in a worrying way. Moreover, carbapenem-hydrolyzing enzymes were found in each of the 3 classes of active-site serine beta-lactamases. [less ▲]

Detailed reference viewed: 34 (15 ULg)
Full Text
Peer Reviewed
See detailIndicators of phosphorus status in soils: Significance and relevance for crop soils in Southern Belgium. A review
Renneson, Malorie ULg; Barbieux, Sophie ULg; Colinet, Gilles ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(S1), 257-272

Detailed reference viewed: 11 (2 ULg)