References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailPhosphine- and ammonium-functionalized ordered mesoporous carbons as supports for cluster-derived metal nanoparticles
Vidick, Deborah; Léonard, Alexandre ULg; Poleunis, Claude et al

in Catalysis Today (2014), 235

An ordered mesoporous carbon (OMC) was functionalized with ammonium or chelating phosphine ligands. In both cases, the functionalization procedure started by oxidation by nitric acid treatment, followed ... [more ▼]

An ordered mesoporous carbon (OMC) was functionalized with ammonium or chelating phosphine ligands. In both cases, the functionalization procedure started by oxidation by nitric acid treatment, followed by activation of surface carboxylic acid groups with thionyl chloride, then formation of amide bonds with diamines. The pendant amine groups were then either quaternized or further reacted with phosphine. The introduced functions were used as anchors for molecular mixed-metal clusters. These organometallic grafted species could then be thermally transformed into hetero-metallic nanoparticles (NP) embedded within the mesoporous framework. The NP/OMC nanocomposites could find application in hydrogenation, heterogeneous catalysis or as electrodes in fuel cells. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailNutritive value of tropical forage plants fed to pigs in the Western provinces of the Democratic Republic of the Congo
Kambashi Mutiaka, Bienvenu ULg; Picron, Pascale ULg; Boudry, Christelle ULg et al

in Animal Feed Science & Technology (2014), 191

The nutritive value of 20 forage plants commonly used for feeding pigs in the Democratic Republic of the Congo was studied to determine chemical composition, protein amino acid profiles, mineral content ... [more ▼]

The nutritive value of 20 forage plants commonly used for feeding pigs in the Democratic Republic of the Congo was studied to determine chemical composition, protein amino acid profiles, mineral content, and in vitro digestibility using a two-step method combining an enzymatic pepsin and pancreatin hydrolysis followed by a 72 h gas-test fermentation. The highest protein contents (270–320 g/kg DM) were obtained for Vigna unguiculata, Psophocarpus scandens, Leucaena leucocephala, Manihot esculenta, and Moringa oleifera. Grasses, Acacia mangium, and Eichhornia crassipes, showed the lowest crude protein (CP) and highest NDF contents. Cajanus cajan and Trypsacum andersonii had the most balanced amino acid profile, being deficient in lysine and slightly deficient in histidine, while Megathyrsus maximus displayed the highest number of essential amino acids deficiencies. High mineral contents were obtained from, in ascending order, with M. oleifera, V. unguiculata, E. crassipes, Ipomea batatas and Amaranthus hybridus. In vitro dry matter digestibility ranged from 0.25 to 0.52, in vitro CP digestibility from 0.23 to 0.80, in vitro energy digestibility from 0.23 to 0.52. M. esculenta, M. oleifera, I. batatas, Mucuna pruriens, V. unguiculata, P. scandens and A. hybridus showed high digestibilities for all nutrients. Gas production during fermentation of the pepsin and pancreatin-indigestible fraction of the plants varied from 42 ml/g DM for A. mangium to 202 ml/g DM for I. batatas (P<0.001). Short-chain fatty acid production during fermentation varied from 157 to 405 mg/g of the pepsin and pancreatin indigestible fraction. It is concluded that some of these species are interesting sources of proteins and minerals with a good digestibility that might be used more economically than concentrate, especially in smallholder production systems, to improve pig feeding, mineral intake and intestinal health in pigs reared in the tropics. [less ▲]

Detailed reference viewed: 24 (7 ULg)
Full Text
Peer Reviewed
See detailConcomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects
Vignisse, Julie ULg; Steinbusch, Harry W.M.; Grigoriev, Vladimir et al

in European Neuropsychopharmacology (2014), 24

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA ... [more ▼]

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA receptors or the potentiation of AMPA receptors is well documented to result in memory enhancement. Here, we compared the efficacy of the low-affinity NMDA receptor blocker memantine or the positive modulator of AMPA receptor QXX (in C57BL/6J at 1 or 5 mg/kg, ip) with new derivatives of isothiourea (0.5-1 mg/kg, ip) that have bifunctional efficacy. Low-affinity NMDA blockade by these derivatives was achieved by introducing greater flexibility into the molecule, and AMPA receptor stimulation was produced by a sulfamide-containing derivative of isothiourea. Contextual learning was examined in a step-down avoidance task and extinction of contextual memory was studied in a fear-conditioning paradigm. Memantine enhanced contextual learning while QXX facilitated memory extinction; both drugs were effective at 5 mg/kg. The new derivative IPAC-5 elevated memory scores in both tasks at the dose 0.5 mg/Kg and exhibited the lowest IC50 values of NMDA receptor blockade and highest potency of AMPA receptor stimulation. Thus, among the new drugs tested, IPAC-5 plicated the properties of memantine and QXX in one administration with increased potency. Our data suggest that a concomitant manipulation of NMDA- and AMPA-receptors results in pro-cognitive effects and supports the concept bifunctional drug therapy as a promising strategy to replace monofunctional therapies with greater efficacy and improved compliance. [less ▲]

Detailed reference viewed: 6 (2 ULg)
Full Text
See detailCR de Anna Drzewicka, "Volez oïr…". Études sur la littérature française du Moyen Âge, Articles des années 1974-2008
Henrard, Nadine ULg

in Bulletin Bibliographique de la Société Rencesvals (2014), 2013-2014(45), 208-212

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailLarge-Scale Clinical Expansion of Mesenchymal Stem Cells in the GMP-Compliant, Closed Automated Quantum® Cell Expansion System: Comparison with Expansion in Traditional T-Flasks
LECHANTEUR, Chantal ULg; Baila, Stefano; Janssen, Michel Etienne et al

in Journal of Stem Cell Research & Therapy (2014), 4(8),

Objectives: Significant advances have been achieved regarding the knowledge of the immunoregulatory properties of mesenchymal stem cells (MSC). We are currently involved in several clinical protocols ... [more ▼]

Objectives: Significant advances have been achieved regarding the knowledge of the immunoregulatory properties of mesenchymal stem cells (MSC). We are currently involved in several clinical protocols evaluating these properties in different settings including hematopoietic cells or solid organ transplantation, and severe or refractory autoimmune disorders. Considering the large number of ex-vivo expanded cells required for these clinical protocols (MSC dose varies from 1 to 4x10-6 MSC/kg patient per infusion), we evaluated the Quantum® device, a GMPcompliant, functionally closed, automated hollow fiber bioreactor system and compared it with our traditional clinical culture system in flasks. Methods: Primary and pre-enriched MSC expansions were simultaneously conducted in both culture systems and evaluated in terms of expansion rates and compliance with quality specifications and ISCT-release criteria. Due to practical considerations, most of the experiments conducted in the bioreactor (P1 and P2 expansions) used thawed MSC. These were compared with both fresh and thawed MSC expansions in flasks. Results: The Quantum® device reproducibly produced therapeutic MSC doses that fulfill ISCT-release criteria, are sterile, devoid of mycoplasma and endotoxin, have normal karyotypes and demonstrate immunosuppressive and differentiation capacities in vitro. Cells also grew faster in the bioreactor than in flasks during passage P1 (doubling time 40 compared to 56 hours in flasks) and P2 expansions but not during the primary expansion phase (P0). Seeding 20x10-6 thawed P2-preselected cells on the device allowed us to harvest 110-276x10-6 MSC after a 7 day expansion; seeding 50x10-6 cells resulted in 291-334x10-6 MSC harvested. Conclusion: In conclusion, the Quantum® device is an excellent system to produce a clinical dose of MSC but cost-effectiveness varies as a function of the manufacturing strategy in place. For our particular situation, the use of the Quantum device didn't result in a cost saving solution. [less ▲]

Detailed reference viewed: 34 (30 ULg)
Full Text
Peer Reviewed
See detailFaire cohabiter les objets sans domicile fixe. Chisholm et les logiques meinongiennes
Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(6), 85-111

Detailed reference viewed: 22 (0 ULg)
Full Text
Peer Reviewed
See detailSimulation-based study comparing multiple imputation methods for non-monotone missing ordinal data in longitudinal settings
Donneau, Anne-Françoise ULg; Mauer, Murielle; Lambert, Philippe ULg et al

in Journal of Biopharmaceutical Statistics (2014)

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the ... [more ▼]

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the joint modeling and the fully conditional specification approaches. Their relative performance for the longitudinal ordinal data setting under the missing at random (MAR) assumption is not well documented. This paper intends to fill this gap by conducting a large simulation study on the estimation of the parameters of a longitudinal proportional odds model. The two MI methods are also illustrated in quality of life data from a cancer clinical trial. [less ▲]

Detailed reference viewed: 56 (15 ULg)
Full Text
Peer Reviewed
See detailThinking out of the box - New approaches to controlling GVHD
Baron, Frédéric ULg; Humblet-Baron, Stéphanie; Ehx, Grégory ULg et al

in Current Hematologic Malignancy Reports (2014), 9

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD ... [more ▼]

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to bebased on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatmentsstill relies on high-dose corticosteroids. Further, no second line treatment has emerged thus far in acute or chronic GVHD patients who failed on corticosteroids. After briefly reviewing current standards of GVHD prevention and treatment, this article will discuss recent approaches that might change GVHD prophylaxis / treatment in the next decades, with a special focus on recently developed immunoregulatory strategies based on infusion of mesenchymal stromal or regulatory T-cells, or on injection of lowdose interleukin-2. [less ▲]

Detailed reference viewed: 34 (11 ULg)
Full Text
Peer Reviewed
See detaildeltaPlotR: An R package for differential item functioning analysis with Angoff's Delta Plot
Magis, David ULg; Facon, Bruno

in Journal of Statistical Software (2014), 59(1), 1-19

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by ... [more ▼]

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by proposing an optimal threshold selection and by considering several item purification processes. Moreover, to support practical DIF analyses with the delta plot and these improvements, the R package deltaPlotR was also developed. The purpose of this paper is twofold: to outline the delta plot by describing the original method and its recent improvements in a user-oriented way, and to illustrate the structure and performances of the deltaPlotR package. A real data set about language skill assessment is being analyzed as an illustrative example. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailExternal nasal valve collapse: validation of novel outcome measurement tool.
POIRRIER, Anne-Lise ULg; Ahluwalia, S.; Kwame, I. et al

in Rhinology (2014), 52(2), 127-32

BACKGROUND: We aim to validate a clinical scoring system of external nasal valve collapse. External nasal valve collapse is a rare and challenging condition. We attempted to simplify the examination of ... [more ▼]

BACKGROUND: We aim to validate a clinical scoring system of external nasal valve collapse. External nasal valve collapse is a rare and challenging condition. We attempted to simplify the examination of the external valve, the surgical planning and the outcome measure. To validate our external valve score, we first assessed its reliability (inter-rater agreement and test-retest repeatability). We secondly considered the clinical relevance by using our scoring system in patients undergoing septorhinoplasty for external valve collapse. METHODOLOGY: For validation, 16 Rhinologists scored patients separately on two occasions. For the clinical relevance, 26 patients with external valve collapse were scored pre- and post-operatively (responsiveness). The external valve score was correlated to peak nasal inspiratory flow. RESULTS: The devised scoring system was reliable (substantial agreement between 16 surgeons with reproducibility over time). All patients in our prospective series showed significant improvement in their external valve score. The quality of life measured by the SNOT-22 tool showed significant improvement after surgery. CONCLUSION: External nasal valve collapse can be diagnosed and graded using this simple scoring system in the outpatient clinic. This paper reinforces the pivotal role of septorhinoplasty surgery in nasal airway reconstruction and the ongoing need to quantify success. [less ▲]

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailPleuresies d'etiologie inattendue: le corps etranger au sein de la cavite pleurale.
Ribera-Jorba, Thaïs; HEINEN, Vincent ULg; Corhay, Jean-Louis ULg et al

in Revue medicale de Liege (2014), 69(1), 38-45

Following three brief clinical reports, we review the literature concerning a rare cause of exudative pleural effusion: the presence of a foreign body in the pleural cavity. Frequently iatrogenical, this ... [more ▼]

Following three brief clinical reports, we review the literature concerning a rare cause of exudative pleural effusion: the presence of a foreign body in the pleural cavity. Frequently iatrogenical, this rare etiology of pleural effusion must be envisaged when this complication develops after any invasive peri-thoracic surgery and must be included in the differential diagnosis of recurrent pleural effusions. These effusions have a favorable prognosis after withdrawal of the foreign body. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detailLa Narcolepsie-Cataplexie aujourd'hui
DEPIERREUX, Frédérique ULg

in Revue Médicale de Liège (2014)

Diagnostic criteria and pathophysiology of narcolepsy- cataplexy have evolved considerably over the last 10 years. The main cause, already mentioned in a previous paper, in the Revue Médicale de Liège, in ... [more ▼]

Diagnostic criteria and pathophysiology of narcolepsy- cataplexy have evolved considerably over the last 10 years. The main cause, already mentioned in a previous paper, in the Revue Médicale de Liège, in 2002, is based, in human beings, on a destruction of specific cells located in the lateral and posterior part of the hypothalamus (the perifornical nuclei, containing some 70,000 neurons), producing peptides which stimulate the central nervous system; they are called hypocretins or orexins. The role of autoimmunity in their disappearance becomes more evident. The treatment is simplified but remains symptomatic. It is mainly based on Sodium Oxybate or Gamma-Hydroxybutyrate, syrup, prescribed for the night. The authors report on their own experience in this regard and on future therapeutics more targeted towards the cause of the disease. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailLA RADIOTHÉRAPIE DANS LE CANCER DU RECTUM CHEZ LA PERSONNE ÂGÉE: Quel bénéfice pour le traitement ?
MARTINIVE, Philippe ULg; ALLEPAERTS, Sophie ULg; VAN DAELE, Daniel ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 47-52

Dans les années à venir, nous serons de plus en plus amenés à prendre en charge des patients âgés en oncologie. Dans ce contexte, quelles sont les évidences scientifiques à notre disposition qui nous ... [more ▼]

Dans les années à venir, nous serons de plus en plus amenés à prendre en charge des patients âgés en oncologie. Dans ce contexte, quelles sont les évidences scientifiques à notre disposition qui nous permettent de prendre en charge de façon correcte cette population oncologique âgée ? Les patients âgés présentent souvent de multiples co-morbidités pouvant interférer avec le traitement oncologique rendant d’autant plus complexe leur prise en charge. Le pic d’inci - dence du cancer du rectum se situe autour des 80 ans, loin au-dessus de l’âge moyen des patients inclus dans les études cliniques. La survie globale des patients traités pour un cancer du rectum s’est améliorée au cours de la dernière décennie, essentiellement pour des patients de moins de 75 ans. Le trai - tement du cancer du rectum nécessite une approche multidis - ciplinaire. L’évaluation gériatrique en fait partie intégrante. Elle permet de définir au mieux la stratégie thérapeutique en fonction de l’état général du patient, de son contexte neuro- psychologique, fonctionnel et social. La radiothérapie joue un rôle majeur dans le traitement du rectum. Quelle est sa place chez les personnes âgées ? Bénéficient-elles également de la radiothérapie, comme la population jeune sélectionnée dans les études contrôlées ? Quel est l’impact de ce traitement sur la qualité de vie ? Voilà des questions essentielles auxquelles nous allons tenter d’apporter une réponse [less ▲]

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailThe premature ejaculation ‘disorder ’: Questioning the criterion of one minute of penetration
Kempeneers, Philippe ULg; Desseilles, Martin ULg

in Sexologies : Revue Européenne de Santé Sexuelle = European Journal of Sexual Health (2014), 23

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio ... [more ▼]

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio-constitutional, and that long-term pharmacological treatment is the only viable option. However, the literature contains little scientific evidence to support this argument. In fact, a good number of individuals who suffer from overly rapid ejaculation present with penetration duration exceeding one minute, and even severe forms of PE have responded favourably to psycho-sexological treatment. Moreover, although certain biological variables are known to influence ejaculation latency time, nothing indicates that they play an exclusive role of psychosocial etiological factors in severe PE. Therefore, it would be ‘premature’ to base a PE diagnosis on a maximum penetration duration of one minute, which should instead be considered a severity gradient. Given that desired criteria for penetration duration often exceed biological norms, it would be inappropriate to propose that only the most severe forms of PE have constitutional origins. In any case, the constitution is relatively flexible, and can respond to adaptive learning. An adaptive learning approach would undoubtedly be more difficult to apply in severe cases, but not impossible. The issue of whether to use pharmacological versus psycho-sexological treatment could be side-stepped by moving beyond the single criterion of ejaculation latency. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detailRegenerative orthopaedics: in vitro, in vivo ... in silico.
Geris, Liesbet ULg

in International orthopaedics (2014), 38(9), 1771-8

In silico, defined in analogy to in vitro and in vivo as those studies that are performed on a computer, is an essential step in problem-solving and product development in classical engineering fields ... [more ▼]

In silico, defined in analogy to in vitro and in vivo as those studies that are performed on a computer, is an essential step in problem-solving and product development in classical engineering fields. The use of in silico models is now slowly easing its way into medicine. In silico models are already used in orthopaedics for the planning of complicated surgeries, personalised implant design and the analysis of gait measurements. However, these in silico models often lack the simulation of the response of the biological system over time. In silico models focusing on the response of the biological systems are in full development. This review starts with an introduction into in silico models of orthopaedic processes. Special attention is paid to the classification of models according to their spatiotemporal scale (gene/protein to population) and the information they were built on (data vs hypotheses). Subsequently, the review focuses on the in silico models used in regenerative orthopaedics research. Contributions of in silico models to an enhanced understanding and optimisation of four key elements-cells, carriers, culture and clinics-are illustrated. Finally, a number of challenges are identified, related to the computational aspects but also to the integration of in silico tools into clinical practice. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailLa conscience et la mort. Le premier Sartre, Bergson, Freud et Ferenczi
Cormann, Grégory ULg

in Etudes Sartriennes (2014), 17

Detailed reference viewed: 28 (7 ULg)
Full Text
Peer Reviewed
See detailFhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.
Joannes, Audrey; Grelet, Simon; Duca, Laurent et al

in Molecular Cancer Research (2014), 12(5), 775-83

In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently decreased or lost. Fhit status has recently been shown to be associated with elevated in vitro and in vivo ... [more ▼]

In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently decreased or lost. Fhit status has recently been shown to be associated with elevated in vitro and in vivo invasiveness in lung cancer. Tumor cell invasion is facilitated by epithelial-mesenchymal transition (EMT), a process by which tumor cells lose their epithelial features to acquire a mesenchymal cell-like phenotype. In this study, the mechanism underlying Fhit-regulated EMT was deciphered. Using Slug knockdown, pharmacologic inhibitors PD98059, PP1, and gefitinib as well as an anti-EGFR antibody, it was demonstrated that Fhit silencing in bronchial cells induced overexpression of two primary EMT-associated targets, MMP-9 and vimentin, to regulate cell invasion dependent on an EGFR/Src/ERK/Slug signaling pathway. Moreover, ectopic expression of Fhit in Fhit-deficient lung cancer cells downregulated this pathway. Finally, an inverse correlation was observed between Fhit and phospho-EGFR levels in a cohort of human squamous cell lung carcinoma specimens. These results demonstrate a Fhit-dependent mechanism in the control of EMT-regulated EGFR signaling. IMPLICATIONS: This study adds new insight into the regulatory mechanism of EMT, a process known to increase resistance to conventional and targeted therapies in lung cancer. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailThe Structure and Thermal Stability of Amylose−Lipid Complexes: A Case Study on Amylose−Glycerol Monostearate
Goderis, Bart; Putseys, Joke; Gommes, Cédric ULg et al

in Journal of Crystal Growth (2014)

Three different crystalline amylose−glycerol monostearate (GMS) complexes with increasing thermal stability can be distinguished: type I, type IIa, and type IIb. All complexes consist of GMS-loaded ... [more ▼]

Three different crystalline amylose−glycerol monostearate (GMS) complexes with increasing thermal stability can be distinguished: type I, type IIa, and type IIb. All complexes consist of GMS-loaded amylose helices that pack hexagonally into lamellar habits. The complex melting points are proportional to the thickness of the lamellae and depend on the amount of water in the system. For type I complexes, SAXS experiments reveal folded amylose chains and a lamellar thickness governed by the presence of two stretched lipid molecules per amylose helix. In the conversion from type I to type IIa complexes, the short amylose chains unfold and assume a stretched conformation, which increases the number of aligned lipid molecules within the helices to four. In type IIb complexes, another pair of lipid molecules is added. The derived quantitative relation between crystal layer thickness, water content and melting point for amylose−GMS complexes also predicts the melting points of other amylose−monoacyl glycerol complexes. [less ▲]

Detailed reference viewed: 82 (6 ULg)
Full Text
Peer Reviewed
See detailEffets d’amendements carbonatés et organiques sur la culture de deux légumes sur sol contaminé à Lubumbashi (RD Congo)
Mpundu Mubemba, Michel; Useni, Yannick; Nyembo, Lucien et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(3), 367-375

Given the risks of contamination of the vegetables grown in gardens in the city of Lubumbashi due to soil pollution, agronomic solutions to reduce these risks have been experimented. The choice of ... [more ▼]

Given the risks of contamination of the vegetables grown in gardens in the city of Lubumbashi due to soil pollution, agronomic solutions to reduce these risks have been experimented. The choice of appropriate amendments (type and quantity) and the selection of plant varieties able to restrict transfers of trace metals (TM) from the soil to plant edible organs are part of the most conventional remediation techniques. Amaranth and spinach beet have been cultivated in pot trials according to randomized complete blocks with four replications on a contaminated soil that received different doses of liming and/or organic products and slightly contaminated soil. Along with an effect on soil chemistry, the amendments have been effective in reducing the transfer of trace metals from soil to plant. The lime-based treatments were more effective than compost. TM levels in plants however remained high whatever the application of amendments and the question of food chain contamination remains posed. [less ▲]

Detailed reference viewed: 27 (5 ULg)
Full Text
Peer Reviewed
See detailCan new information and communication technologies help in the management of osteoporosis ?
Slomian, Justine ULg; Appelboom, G; Ethgen, Olivier ULg et al

in Women's Health (2014), 10(3), 229-232

Detailed reference viewed: 20 (4 ULg)
Full Text
See detailCompte-rendu de l'ouvrage de Eilene Powell et al.: La novela sugestiva
Ceballos Viro, Alvaro ULg

in Iberoamericana America Latina-Espana-Portugal (2014), (53), 218-220

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailLE MÉDICAMENT DU MOIS L’acétate d’ulipristal (Esmya®) : un modulateur sélectif des récepteurs à la progestérone, nouveau traitement de la fibromatose utérine
Nisolle, Michelle ULg; CLOSON, François ULg; FIRQUET, Anne ULg et al

in Revue Médicale de Liège (2014), 69(4), 220-225

Ulipristal acetate (Esmya®) : a selective modulator of progesterone receptors, new treatment of uterine fibromatosis Summary : Uterine fibromatosis is a frequent benign gynaecological disease causing ... [more ▼]

Ulipristal acetate (Esmya®) : a selective modulator of progesterone receptors, new treatment of uterine fibromatosis Summary : Uterine fibromatosis is a frequent benign gynaecological disease causing heavy menstrual bleeding and in some cases anaemia. Until now, medical treatment aimed to obtain amenorrhea by administration of progestins or Gn-RH agonists. By inducing hypo-oestrogenism, a reduction of myoma size is observed with Gn-RH agonists but after cessation of the treatment, initial myoma size is noted. The impact of progesterone in myoma growth is nowadays demonstrated and use of selective modulators of progesterone receptors represents a new medical approach of this disease. [less ▲]

Detailed reference viewed: 80 (18 ULg)
Full Text
Peer Reviewed
See detailWomen's skin throughout lifetime.
PIERARD, Gérald ULg; CHARLIER, Corinne ULg; Delvenne, Philippe ULg et al

in BioMed Research International (2014), 2014

Detailed reference viewed: 20 (6 ULg)
Full Text
Peer Reviewed
See detailNotes on Early Land Plants Today. Transfer of Iwatsukia to Odontoschisma (Cephaloziaceae, Marchantiophyta)
Gradstein, S.R.; Aranda; Vanderpoorten, Alain ULg

in Phytotaxa (2014), 162

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailDisease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer.
Andre, Fabrice; Neven, Patrick; Marinsek, Nina et al

in Current medical research and opinion (2014)

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of ... [more ▼]

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of hormonal therapy (HT), and only recommend chemotherapy for patients with extensive visceral involvement or rapidly progressive disease. This study evaluated actual physician-reported treatments for advanced BC in Europe. Methods: We conducted a retrospective chart review of 355 postmenopausal women with HR+, HER2- advanced BC who progressed on >/=1 line of HT (adjuvant or advanced) and completed >/=1 line of chemotherapy (advanced). Treatment choice was evaluated for each line of therapy. Results: Of 355 patients, 111 (31%) received first-line chemotherapy, whereas 218 (61%) and 26 (7%) switched from HT to chemotherapy in second and third line, respectively. More patients receiving first-line HT had bone metastases (73% vs 27% chemotherapy). Patients treated with first-line chemotherapy had more brain (12% vs 3% HT) or extensive liver (13% vs 6% HT) metastases. Subgroup analysis of 188 patients who received first-line HT and had de novo advanced BC or relapsed/recurrent disease more than 1 year after adjuvant therapy found that the majority (89%; n = 167) of these patients switched to chemotherapy in second line. However, among these 167 patients, 27% had no significant changes in metastases between first and second line. Among the 73% of patients who had significant changes in metastases, 20% had no brain metastases or extensive visceral disease. Conclusions: Our study suggests that the guideline-recommended use of multiple HT lines is open to interpretation and that optimal treatment for European postmenopausal women with HR+, HER2- advanced BC who responded to HT may not be achieved. [less ▲]

Detailed reference viewed: 17 (4 ULg)
Full Text
Peer Reviewed
See detailAtrial Natriuretic Peptide as an indicator of the severity of valvular regurgitation and heart failure in horses
Leroux, Aurélia ULg; Al Haidar, Ali; Remy, Benoît ULg et al

in Journal of Equine Veterinary Science (2014), in press

Natriuretic peptides are cardiac biomarkers, routinely used for diagnosis, prognosis, and guidance for treatment in human and small animal cardiology. However, their diagnostic and prognostic value in ... [more ▼]

Natriuretic peptides are cardiac biomarkers, routinely used for diagnosis, prognosis, and guidance for treatment in human and small animal cardiology. However, their diagnostic and prognostic value in horses has received little study. The aim of this study was to investigate the plasma atrial natriuretic concentration (ANPPl) in a large group of horses with various degrees of valvular regurgitation (VR) and congestive heart failure (CHF). Clinical examination and two-dimensional, time-motion mode and Doppler echocardiography were performed on 91 horses admitted to the Equine Teaching Hospital of Liege University, with either no, mild, moderate or severe VR and presenting various stages of CHF. ANPPl was measured using a commercially available human RIA test. Mean values of body weight, age, ANPPl and echocardiographic parameters were compared between horses with no, mild, moderate and severe VR and between horses in different CHF stages. Correlation and linear regression of ANPPl with each echocardiographic parameter and with the percentage of dilation of each of cardiac chambers were assessed. Horses with severe or moderate VR had significantly higher ANPPl than horses with mild or no VR. ANPPl was significantly higher in horses presenting CHF than in horses without CHF. ANPPl was significantly correlated with the left atrial diameter and its percentage of dilation. These results suggest a diagnostic value of ANPPl in horses with VR, especially with tricuspid or mitral insufficiency with dilation of the atria. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailDioxins and polychlorinated biphenyls contamination in poultry liver related to food safety - A review
Ghimpeteanu, Oana-Margarita; Militaru, Manuella; Scippo, Marie-Louise ULg

in Food Control (2014), 38

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated ... [more ▼]

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants with high chemical stability; they are lipophilic compounds and they are not destroyed by microbial, photochemical, chemical or thermal degradation. Dioxins and PCBs are ubiquitous environmental contaminants, which are present in all marine plant and animals, birds, mammals and humans and bioaccumulate through the food chain. In the last years, there has been concern regarding food contamination with different chemical substances and their effect on food safety. More particularly, at the end of the 20th and the beginning of the 21st century, there were a series of incidents related to dioxin and PCBs, which directly affected human or contaminated the soil and accumulated in feed and then in food products, such as poultry liver. It was shown in case of dioxin incident that tetra and penta-chlorinated congeners (the most toxic ones) accumulates selectively in poultry livers. Maximal concentrations have been fixed in the European legislation for dioxins and PCBs in food from animal origin, in order to protect the consumer. Data about background poultry liver contamination are scarce and the few available show levels below the legal limit for dioxins, but data are still lacking for DL-PCBs. [less ▲]

Detailed reference viewed: 34 (5 ULg)
Full Text
Peer Reviewed
See detailPractice of enteral nutrition in very low birth weight and extremely low birth weight infants
SENTERRE, Thibault ULg

in World Review of Nutrition and Dietetics (2014), 110

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailDrug-Drug Interactions with Sodium-Glucose Cotransporters Type 2 (SGLT2) Inhibitors, New Oral Glucose-Lowering Agents for the Management of Type 2 Diabetes Mellitus.
Scheen, André ULg

in Clinical pharmacokinetics (2014)

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. They are proposed as a novel ... [more ▼]

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. They are proposed as a novel approach for the management of type 2 diabetes mellitus. They have proven their efficacy in reducing glycated haemoglobin, without inducing hypoglycaemia, as monotherapy or in combination with various other glucose-lowering agents, with the add-on value of promoting some weight loss and lowering arterial blood pressure. As they may be used concomitantly with many other drugs, we review the potential drug-drug interactions (DDIs) regarding the three leaders in the class (dapagliglozin, canagliflozin and empagliflozin). Most of the available studies were performed in healthy volunteers and have assessed the pharmacokinetic interferences with a single administration of the SGLT2 inhibitor. The exposure [assessed by peak plasma concentrations (C max) and area under the concentration-time curve (AUC)] to each SGLT2 inhibitor tested was not significantly influenced by the concomitant administration of other glucose-lowering agents or cardiovascular agents commonly used in patients with type 2 diabetes. Reciprocally, these medications did not influence the pharmacokinetic parameters of dapagliflozin, canagliflozin or empagliflozin. Some modest changes were not considered as clinically relevant. However, drugs that could specifically interfere with the metabolic pathways of SGLT2 inhibitors [rifampicin, inhibitors or inducers of uridine diphosphate-glucuronosyltransferase (UGT)] may result in significant changes in the exposure of SGLT2 inhibitors, as shown for dapagliflozin and canagliflozin. Potential DDIs in patients with type 2 diabetes receiving chronic treatment with an SGLT2 inhibitor deserve further attention, especially in individuals treated with several medications or in more fragile patients with hepatic and/or renal impairment. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailOleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig.
Horcajada, M.-N.; Sanchez, Christelle ULg; Membrez Scalfo et al

in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society (2014)

OBJECTIVE: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, on joint ageing and osteoarthritis (OA) development. DESIGN: Sixty 4-week-old Dunkin-Hartley ... [more ▼]

OBJECTIVE: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, on joint ageing and osteoarthritis (OA) development. DESIGN: Sixty 4-week-old Dunkin-Hartley guinea pigs were randomized into four groups and received daily during 31 weeks either standard guinea pig diet (control group) or a standard guinea pig diet enriched with oleuropein (0.025%), rutin (0.5%) or rutin/curcumin (0.5%/0.25%) association. Biomarkers of OA (Coll2-1, Coll2-1NO2, Fib3-1, Fib3-2, ARGS), as well as inflammation (PGE2) were quantified in the serum. Histological assessments of knee cartilage and synovial membrane were performed at week 4 (five young reference guinea pigs) and week 35. RESULTS: At week 35, guinea pigs in the control group spontaneously developed significant cartilage lesions with mild synovial inflammation. The histological scores of cartilage lesions and synovitis were well correlated with the increased level of serum biomarkers. Histologically, all treatments significantly reduced the cartilage degradation score (P < 0.01), but only oleuropein significantly decreased the synovial histological score (P < 0.05) and serum PGE2 levels (P < 0.01) compared to the control group. Coll2-1 was decreased by rutin and the combination of rutin/curcumin, Fib3-1 and Fib3-2 were only decreased by the rutin/curcumin mixture, while Coll2-1NO2 was significantly decreased by all treatments (P < 0.05). CONCLUSION: Oleuropein and rutin +/- curcumin significantly slowed down the progression of spontaneous OA lesions in guinea pigs. While no additive effect was seen in the curcumin + rutin group, the differential effects of oleuropein and rutin on inflammatory and cartilage catabolic markers suggest an interesting combination for future studies in OA protection. [less ▲]

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailRecension: "Invloed van het Europese recht op het Belgisch privaatrecht"
Kohl, Benoît ULg

in Droit de la Consommation = Consumentenrecht [= DCCR] (2014), (102), 139-142

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailEmbryonic Protein Undernutrition by Albumen Removal Programs the Hepatic Amino Acid and Glucose Metabolism during the Perinatal Period in an Avian Model.
Willems, Els; Hu, Tjing-Tjing; Soler Vasco, Laura et al

in PloS one (2014), 9(4), 94902

Different animal models have been used to study the effects of prenatal protein undernutrition and the mechanisms by which these occur. In mammals, the maternal diet is manipulated, exerting both direct ... [more ▼]

Different animal models have been used to study the effects of prenatal protein undernutrition and the mechanisms by which these occur. In mammals, the maternal diet is manipulated, exerting both direct nutritional and indirect hormonal effects. Chicken embryos develop independent from the hen in the egg. Therefore, in the chicken, the direct effects of protein deficiency by albumen removal early during incubation can be examined. Prenatal protein undernutrition was established in layer-type eggs by the partial replacement of albumen by saline at embryonic day 1 (albumen-deprived group), compared to a mock-treated sham and a non-treated control group. At hatch, survival of the albumen-deprived group was lower compared to the control and sham group due to increased early mortality by the manipulation. No treatment differences in yolk-free body weight or yolk weight could be detected. The water content of the yolk was reduced, whereas the water content of the carcass was increased in the albumen-deprived group, compared to the control group, indicating less uptake of nutrients from the yolk. At embryonic day 16, 20 and at hatch, plasma triiodothyronine (T3), corticosterone, lactate or glucose concentrations and hepatic glycogen content were not affected by treatment. At embryonic day 20, the plasma thyroxine (T4) concentrations of the albumen-deprived embryos was reduced compared to the control group, indicating a decreased metabolic rate. Screening for differential protein expression in the liver at hatch using two-dimensional difference gel electrophoresis revealed not only changed abundance of proteins important for amino acid metabolism, but also of enzymes related to energy and glucose metabolism. Interestingly, GLUT1, a glucose transporter, and PCK2 and FBP1, two out of three regulatory enzymes of the gluconeogenesis were dysregulated. No parallel differences in gene expressions causing the differences in protein abundance could be detected pointing to post-transcriptional or post-translational regulation of the observed differences. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailUpdated standards and processes for accreditation of echocardiographic laboratories from The European Association of Cardiovascular Imaging.
Popescu, Bogdan A.; Stefanidis, Alexandros; Nihoyannopoulos, Petros et al

in European heart journal cardiovascular Imaging (2014)

Standards for echocardiographic laboratories were proposed by the European Association of Echocardiography (now the European Association of Cardiovascular Imaging) 7 years ago in order to raise standards ... [more ▼]

Standards for echocardiographic laboratories were proposed by the European Association of Echocardiography (now the European Association of Cardiovascular Imaging) 7 years ago in order to raise standards of practice and improve the quality of care. Criteria and requirements were published at that time for transthoracic, transoesophageal, and stress echocardiography. This paper reassesses and updates the quality standards to take account of experience and the technical developments of modern echocardiographic practice. It also discusses quality control, the incentives for laboratories to apply for accreditation, the reaccreditation criteria, and the current status and future prospects of the laboratory accreditation process. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailKinetic study of 4-nitrophenol photocatalytic degradation over a Zn2+ doped TiO2 catalyst prepared through an environmentally friendly aqueous sol–gel process
Malengreaux, Charline ULg; Pirard, Sophie ULg; Bartlett, John et al

in Chemical Engineering Journal (2014), 245

A kinetic study of the photocatalytic degradation of 4-nitrophenol (4-NP) under UV–visible light (330 nm < k < 800 nm) has been performed via a rigorous chemical engineering approach over a Zn2+ doped ... [more ▼]

A kinetic study of the photocatalytic degradation of 4-nitrophenol (4-NP) under UV–visible light (330 nm < k < 800 nm) has been performed via a rigorous chemical engineering approach over a Zn2+ doped TiO2 catalyst prepared through an environmentally friendly aqueous sol–gel process. The experiments have been performed at three temperatures to enable the global activation energy to be estimated. The influence of the illumination intensity has also been considered. The possibility of internal and external diffusion limitations has been studied and the results obtained demonstrated that there is no diffusional limitation during the photocatalytic degradation of the 4-NP using the selected catalyst. Therefore, the apparent specific reaction rate measured corresponds to the actual reaction rate of the chemical reaction. Parameter adjustments show that the kinetic model that provides the best fit to the experimental data corresponds to a first order reaction. A sequence of elementary steps has been considered and a pseudo-steady state approach based upon the stationary state hypothesis for reaction intermediates has been applied to obtain a kinetic rate expression in agreement with the experimental data. The mean values of the reaction rate constant found at 283 K, 288 K and 293 K are respectively equal to k1 = 0.094 ± 0.003 m3 h- 1 kgcatalyst- 1; k2 = 0.119 ± 0.004 m3 h- 1 kgcatalyst- 1 and k3 = 0.150 ± 0.023 m3 h- 1 kg catalyst-1 and the global activation energy of the degradation reaction was evaluated as 40 kJ mol-1. A phenomenological kinetic mechanism is proposed to describe the reaction at a molecular scale. Finally, statistical validations and residuals analysis have been performed to confirm that the first order model is suitable to represent the 4-NP photocatalytic degradation over time. Such studies are essential to design a reactor for water pollutant degradation on an industrial scale. [less ▲]

Detailed reference viewed: 31 (12 ULg)
Full Text
Peer Reviewed
See detailCardiovascular imaging.
Lancellotti, Patrizio ULg; Habib, Gilbert; Negila, Danilo et al

in European heart journal (2014), 35(18), 1161-2

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailIndirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women.
Ellis, Alexandra G.; Reginster, Jean-Yves ULg; Luo, Xuemei et al

in Current medical research and opinion (2014), 30(8), 1617-1626

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on ... [more ▼]

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on evidence from randomized controlled trials (RCTs). Methods: Eight RCTs assessing vertebral fracture risk reduction with oral bisphosphonates (n = 7) or bazedoxifene (n = 1) were identified by a systematic literature review. Individual study results were pooled in a network meta-analysis (NMA) to indirectly compare treatment effects for overall PMO women and a higher-risk subgroup (FRAX >/= 20%). Three sets of NMA analyses were conducted: aggregate data (AD) from the bisphosphonate RCTs and bazedoxifene RCT for the full population or the FRAX >/=20% subgroup (NMA AD); bisphosphonate AD and bazedoxifene AD from each FRAX subgroup adjusted for baseline risk (NMA AD meta-regression); and bisphosphonate AD and bazedoxifene individual patient data (IPD) adjusted for baseline risk/FRAX (NMA AD/IPD meta-regression). Results: For the overall population, bisphosphonates had lower fracture risks versus bazedoxifene although there is considerable uncertainty in supporting one intervention over another. The relative risk reduction (RRR) for bazedoxifene was -0.23 (95% CrI: -1.11, 0.27) versus ibandronate, -0.17 (-0.76, 0.22) versus alendronate, and -0.06 (-0.62, 0.30) versus risedronate. Results from the meta-regression analyses were similar. For the FRAX >/=20% population, estimated fracture rates with bazedoxifene were lower than with bisphosphonates, but again the uncertainty limits strong interpretation. The RRR for bazedoxifene was 0.51 (-0.31, 0.83) versus ibandronate, 0.53 (-0.18, 0.83) versus alendronate, and 0.57 (-0.07, 0.85) versus risedronate. The meta-regression analyses showed comparable findings. Conclusion: The analyses only considered vertebral fractures for oral bisphosphonates versus bazedoxifene, and IPD was available only for bazedoxifene. In light of this, bazedoxifene is comparable to bisphosphonates in the overall PMO population and at least as effective as bisphosphonates for preventing vertebral fractures among higher-risk PMO patients. The findings suggest bazedoxifene performs better in higher-risk PMO than in the overall PMO. [less ▲]

Detailed reference viewed: 15 (7 ULg)
Full Text
Peer Reviewed
See detailBrentano's "Descriptive" Realism
Seron, Denis ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(4), 1-14

Brentano’s metaphysical position in Psychology from an Empirical Standpoint is usually assumed to be metaphysical realism. I propose an alternative interpretation, according to which Brentano was at that ... [more ▼]

Brentano’s metaphysical position in Psychology from an Empirical Standpoint is usually assumed to be metaphysical realism. I propose an alternative interpretation, according to which Brentano was at that time, as well as later, a full-fledged phenomenalist. However, his phenomenalism is markedly different from standard phenomenalism in that it does not deny that the physicist’s judgments are really about the objective world. The aim of the theory of intentionality, I argue, is to allow for extra-phenomenal aboutness within a phenomenalist framework. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailGalectin Expression Profiling Identifies Galectin-1 and Galectin-9Δ5 as Prognostic Factors in Stage I/II Non-Small Cell Lung Cancer
Schulkens, Iris; Heusschen, Roy ULg; Van den boogaart, Vivianne et al

in PLoS ONE (2014)

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailThe quantified patient: a patient participatory culture.
Appelboom, Geoff; LoPresti, Melissa; Reginster, Jean-Yves ULg et al

in Current medical research and opinion (2014)

Abstract The Quantified Self Movement, which aims to improve various aspects of life and health through recording and reviewing daily activities and biometrics, is a new and upcoming practice of self ... [more ▼]

Abstract The Quantified Self Movement, which aims to improve various aspects of life and health through recording and reviewing daily activities and biometrics, is a new and upcoming practice of self monitoring that holds much promise. Now, the most underutilized resource in ambulatory health care, the patient, can participate like never before, and the patient's Quantified Self can be directly monitored and remotely accessed by health care professionals. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailEverolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial.
Andre, Fabrice; O'Regan, Ruth; Ozguroglu, Mustafa et al

in The lancet oncology (2014)

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to ... [more ▼]

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited women with HER2-positive, trastuzumab-resistant, advanced breast carcinoma who had previously received taxane therapy. Eligible patients were randomly assigned (1:1) using a central patient screening and randomisation system to daily everolimus (5 mg/day) plus weekly trastuzumab (2 mg/kg) and vinorelbine (25 mg/m2) or to placebo plus trastuzumab plus vinorelbine, in 3-week cycles, stratified by previous lapatinib use. The primary endpoint was progression-free survival (PFS) by local assessment in the intention-to-treat population. We report the final analysis for PFS; overall survival follow-up is still in progress. This trial is registered with ClinicalTrials.gov, number NCT01007942. FINDINGS: Between Oct 26, 2009, and May 23, 2012, 569 patients were randomly assigned to everolimus (n=284) or placebo (n=285). Median follow-up at the time of analysis was 20.2 months (IQR 15.0-27.1). Median PFS was 7.00 months (95% CI 6.74-8.18) with everolimus and 5.78 months (5.49-6.90) with placebo (hazard ratio 0.78 [95% CI 0.65-0.95]; p=0.0067). The most common grade 3-4 adverse events were neutropenia (204 [73%] of 280 patients in the everolimus group vs 175 [62%] of 282 patients in the placebo group), leucopenia (106 [38%] vs 82 [29%]), anaemia (53 [19%] vs 17 [6%]), febrile neutropenia (44 [16%] vs ten [4%]), stomatitis (37 [13%] vs four [1%]), and fatigue (34 [12%] vs 11 [4%]). Serious adverse events were reported in 117 (42%) patients in the everolimus group and 55 (20%) in the placebo group; two on-treatment deaths due to adverse events occurred in each group. INTERPRETATION: The addition of everolimus to trastuzumab plus vinorelbine significantly prolongs PFS in patients with trastuzumab-resistant and taxane-pretreated, HER2-positive, advanced breast cancer. The clinical benefit should be considered in the context of the adverse event profile in this population. FUNDING: Novartis Pharmaceuticals Corporation. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailComparison of two FFPE preparation methods using label-free shotgun proteomics: Application to tissues of diverticulitis patients.
Quesada-Calvo, Florence; Bertrand, Virginie ULg; Longuespée, Rémi ULg et al

in Journal of proteomics (2014), 112C

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic ... [more ▼]

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic biomarkers. However, the critical step in this field is the ability to obtain an efficient and repeatable extraction using the limited quantities of material available for research in hospital biobanks. This work describes the evaluation of the peptide/protein extraction using FFPE sections treated by the following two methods before shotgun proteomic analysis: a commercial solution (FFPE-FASP) (filter aided sample preparation) and an antigen retrieval-derived protocol (On Slice AR). Their efficiencies and repeatabilities are compared using data-independent differential quantitative label-free analysis. FFPE-FASP was shown to be globally better both qualitatively and quantitatively than On Slice AR. FFPE-FASP was tested on several samples, and differential analysis was used to compare the tissues of diverticulitis patients (healthy and inflammatory tissues). In this differential proteomic analysis using retrospective clinical FFPE material, FFPE-FASP was reproducible and provided a high number of confident protein identifications, highlighting potential protein biomarkers. BIOLOGICAL SIGNIFICANCE: In clinical proteomics, FFPE is an important resource for retrospective analysis and for the discovery of biomarkers. The challenge for FFPE shotgun proteomic analysis is preparation by an efficient and reproducible protocol, which includes protein extraction and digestion. In this study, we analyzed two different methods and evaluated their repeatabilities and efficiencies. We illustrated the reproducibility of the most efficient method, FFPE-FASP, by a pilot study on diverticulitis tissue and on FFPE samples amount accessible in hospital biobanks. These data showed that FFPE is suitable for use in clinical proteomics, especially when the FFPE-FASP method is combined with label-free shotgun proteomics as described in the workflow presented in this work. [less ▲]

Detailed reference viewed: 14 (5 ULg)
Full Text
Peer Reviewed
See detailMesophilic biohydrogen production by Clostridium butyricum CWBI1009 in trickling biofilter reactor
Puhulwella, Rathnasiri G.; Beckers, Laurent; Delvigne, Frank ULg et al

in International Journal of Hydrogen Energy (2014), (0),

Detailed reference viewed: 10 (3 ULg)
Full Text
See detailGynecologic and obstetric impact of the Ehlers-Danlos syndrome: clues from scrutinizing dermal ultrastructural alterations.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Gynecology (2014), 2(1),

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective ... [more ▼]

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissue fragility. Each EDS type corresponds to a multisystemic disorder with widespread implications. Physicians evoke the EDS diagnosis in presence of some typical cutaneous signs, such as atrophic scars and frequent hematomas. Methods: To revisit the transmission electron microscopy support from skin biopsies when screening EDS in gynecology-obstetrics. Results: EDS women commonly suffer from a series of gynecologic and obstetric disorders. Dermal ultrastructural changes are keynote features suggesting some EDS types. Conclusion: Gene mutations are mostly identified in the classic and vascular EDS types, but only in sporadic cases of the hypermobile EDS type which apparently represents the most frequent type. Dermal ultrastructural changes represent relevant diagnostic clues for the practitioner. Preconception counseling about possible complications is welcome. Management requires precise diagnosis of the EDS type. [less ▲]

Detailed reference viewed: 27 (1 ULg)
Full Text
Peer Reviewed
See detailThe anagenetic world of spore-producing land plants.
Patino Llorente, Jairo; Carine, M.A.; Fernández-Palacios, J.M. et al

in New Phytologist (2014), 201

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailAnalysis of collagen preservation in bones recovered in archaeological contexts using NIR Hyperspectral Imaging
Vincke, Damien; Miller, Rebecca ULg; Stassart, Edith ULg et al

in Talanta (2014), 125

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen ... [more ▼]

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen preservation in bones recovered from archaeological contexts. This preliminary study has allowed the evaluation of the potential of the method using bone samples from the Early Upper Palaeolithic, Mesolithic and Neolithic periods at the site of Trou Al'Wesse in Belgium. NIR-HCI, combined with chemometric tools, has identified specific spectral bands characteristic of collagen. A chemometric model has been built using Partial Least Squares Discriminant Analysis (PLS-DA) to identify bones with and without collagen. This enables the evaluation of the degree of collagen preservation and homogeneity in bones within and between different strata, which has direct implications for archaeological applications (e.g., taphonomic analyses, assemblage integrity) and sample selection for sub- sequent analyses requiring collagen. Two archaeological applications are presented: comparison between sub-layers in an Early Upper Palaeolithic unit, and evaluation of the range of variability in collagen preservation within a single Holocene stratum. [less ▲]

Detailed reference viewed: 28 (6 ULg)
Full Text
Peer Reviewed
See detailNew role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline ULg; Renert, Anne-Françoise; Merville, Marie-Paule ULg et al

in Autophagy (2014)

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]

Detailed reference viewed: 100 (18 ULg)
Full Text
Peer Reviewed
See detailScreening for malnutrition in lung cancer patients undergoing therapy
BARTHELEMY, Nicole ULg; Streel, Sylvie ULg; Donneau, Anne-Françoise ULg et al

in Supportive Care in Cancer (2014), 22(6), 15311536

Detailed reference viewed: 22 (12 ULg)
Full Text
See detailInfluence du changement climatique sur l'accroissement du hêtre en Wallonie
Latte, Nicolas ULg; Claessens, Hugues ULg

in Forêt Wallonne (2014), (129), 46-47

Detailed reference viewed: 19 (5 ULg)
Full Text
Peer Reviewed
See detailAmphetamine reward in food restricted mice lacking the melanin-concentrating hormone receptor-1
Geuzaine, A; Tyhon, A; Grisar, Thierry ULg et al

in Behavioural Brain Research (2014), 262

Detailed reference viewed: 34 (6 ULg)
Peer Reviewed
See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging: Part II.
Plein, Sven; Edvardsen, Thor; Pierard, Luc ULg et al

in European heart journal cardiovascular Imaging (2014)

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in ... [more ▼]

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in two articles. Part I of the review has summarized studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging. Part II is focussed on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailStrategies to combine novel traits across countries: example of heat stress
Hammami, Hedi ULg; Vandenplas, Jérémie ULg; Carabaño, Maria Jesus et al

in Interbull Bulletin (2014), 48

Nowadays, novel traits are of great interest. However, phenotypes are siloed and mainly not shared. Heat stress is becoming problematic affecting animals’ performances and their well-being. Heat stress ... [more ▼]

Nowadays, novel traits are of great interest. However, phenotypes are siloed and mainly not shared. Heat stress is becoming problematic affecting animals’ performances and their well-being. Heat stress tolerance as a novel trait is only addressed by isolated within-country research studies. Integration and combination of local and foreign information sources is needed for better accuracy genetic evaluations. Therefore, this study was aimed to test the potential combination of sources of external information towards the evaluation of heat stress tolerance of dairy cattle. Long-term cow performances linked to environmental descriptors (weather parameters as proxy to climate change) collected over 10 years under the temperate conditions of the Walloon Region of Belgium and the hotter and warm Mediterranean conditions of Andalusia and Castile-La-Mancha Spanish regions were available. A total of 1,604,775 milk, fat, and protein test-day (TD) records linked to average daily temperature humidity (THI) values for 3-day lag before each TD were considered. Under a first strategy considering free-access to raw-data (phenotype and pedigree), a joint evaluation was firstly run using reaction norm models where production traits were considered as function of THI. A Belgian and a Spanish evaluation were also run using the same model. An alternative strategy considering only access to external information (i.e. regression coefficients for additive genetic effects (â and their associated REL)) was tested. In this case, foreign â and their REL resulting from the Spanish evaluation were first converted to the Belgian trait and thereafter integrated in the Belgian evaluation using a Bayesian approach. Rank correlations between regression coefficients, â (of the 1,104 bulls having daughters only in Spain) estimated by Belgian evaluation and â estimated by the joint evaluation were moderate (<=0.70). Corresponding rank correlations between â estimated by joint and Bayesian evaluations were significantly higher (ranging from 0.967 to 0.998), indicating that the Bayesian evaluation integrating external information was in good concordance with the joint evaluation. Results from this study indicated that the integration of external information via the Bayesian approach has a good potential to improve the genetic evaluation of sparse and siloed novel traits. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailLe « trouble » de l’éjaculation précoce : Le critère d’une minute maximum de pénétration en question
Kempeneers, Philippe ULg; Desseilles, Martin ULg

in Sexologies : Revue Européenne de Santé Sexuelle = European Journal of Sexual Health (2014), 23

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio ... [more ▼]

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio-constitutional, and that long-term pharmacological treatment is the only viable option. However, the literature contains little scientific evidence to support this argument. In fact, a good number of individuals who suffer from overly rapid ejaculation present with penetration duration exceeding one minute, and even severe forms of PE have responded favourably to psycho-sexological treatment. Moreover, although certain biological variables are known to influence ejaculation latency time, nothing indicates that they play an exclusive role of psychosocial etiological factors in severe PE. Therefore, it would be ‘premature’ to base a PE diagnosis on a maximum penetration duration of one minute, which should instead be considered a severity gradient. Given that desired criteria for penetration duration often exceed biological norms, it would be inappropriate to propose that only the most severe forms of PE have constitutional origins. In any case, the constitution is relatively flexible, and can respond to adaptive learning. An adaptive learning approach would undoubtedly be more difficult to apply in severe cases, but not impossible. The issue of whether to use pharmacological versus psycho-sexological treatment could be side-stepped by moving beyond the single criterion of ejaculation latency. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailHorizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits.
Megens, Sarah; Vaira, Dolores; De Baets, Greet et al

in Virology (2014), 456-457

We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI ... [more ▼]

We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I). Concurrently, the NRTI mutations T69I and V118I and the NNRTI mutations K103N and Y181C were detected for the first time. High-level drug resistance (fold-changes>/=50) and a good replication capacity (87% of wild-type) were observed, significantly higher than for the previous virus without insertion. The insertion was very similar to a region within human chromosome 17 (31/34 nucleotide identity), and had already been detected independently in a Japanese HIV-1 isolate. These results suggest that a particular sequence within human chromosome 17 is prone to horizontal gene transfer into the HIV-1 RT finger subdomain. This insertion confers selective advantage to HIV-1 by its contribution to multi-drug resistance and restoration of impaired replication capacity. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailHéra et Zeus à Lesbos : entre poésie lyrique et décret civique
Pirenne-Delforge, Vinciane ULg; Pironti, Gabriella

in Zeitschrift für Papyrologie und Epigraphik (2014), 191

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailComparative study of alkaline extraction process of hemicelluloses from pear pomace
Rabetafika, Holy-Nadia ULg; Bchir, Brahim ULg; Blecker, Christophe ULg et al

in Biomass & Bioenergy (2014), 61

Hemicelluloses were produced from pear pomace using direct alkaline extraction (sodium hydroxide and hydrogen peroxide) and two-step extraction with delignification pre-treatment (acidified sodium ... [more ▼]

Hemicelluloses were produced from pear pomace using direct alkaline extraction (sodium hydroxide and hydrogen peroxide) and two-step extraction with delignification pre-treatment (acidified sodium chlorite/sodium hydroxide). The aim of the study was to compare the extraction yield, composition and physicochemical characteristics of isolated hemicelluloses by size exclusion chromatography, FTIR and thermogravimetric analyses. Solid residues were analysed in order to evaluate the effect of processes on co-products (lignins and cellulose). Delignification of material (up to 995.4 g kg−1 of original lignins) during the direct alkaline hydrogen peroxide and two-step acidified sodium chlorite/sodium hydroxide processes improved the hemicellulose extraction yield attaining up to 945.3 g kg−1. Hemicelluloses were mainly composed of xylans (xylose/glucose ratio of 4.6–16.2) and had low lignin content (53.5–61.0 g kg−1 dry matter). Those from direct sodium hydroxide extraction were composed of xylans and glucans (xylose/glucose ratio of 1.5) with high content of lignins (149.3 g kg−1 dry matter). All isolated fractions were a mixture of polymers and oligomers with a molecular mass ranging from 1710 g mol−1 to 8 870 000 g mol−1. The two-step process gave the most pure cellulose residue (799.2 g kg−1 dry matter). According to results, the direct alkaline extraction with hydrogen peroxide was a promising process for the production of pure xylose-rich hemicelluloses from pear pomace solubilizing 802.2 g kg−1 of the original hemicelluloses but induced fragmentation of hemicelluloses. [less ▲]

Detailed reference viewed: 19 (8 ULg)
Full Text
Peer Reviewed
See detailTo settle or to move? The interplay between two classes of cyclic lipopeptides in the biocontrol strain Pseudomonas CMR12a
D’aes, J.; Phuong Kieu, N.; Leclère, V. et al

in Environmental Microbiology (2014), In press

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailInflorescence development in tomato: gene functions within a zigzag model.
Périlleux, Claire ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg

in Frontiers in Plant Science (2014), 5

Tomato is a major crop plant and several mutants have been selected for breeding but also for isolating important genes that regulate flowering and sympodial growth. Besides, current research in ... [more ▼]

Tomato is a major crop plant and several mutants have been selected for breeding but also for isolating important genes that regulate flowering and sympodial growth. Besides, current research in developmental biology aims at revealing mechanisms that account for diversity in inflorescence architectures. We therefore found timely to review the current knowledge of the genetic control of flowering in tomato and to integrate the emerging network into modeling attempts. We developped a kinetic model of the tomato inflorescence development where each meristem was represented by its ‘vegetativeness’ (V), reflecting its maturation state towards flower initiation. The model followed simple rules: maturation proceeded continuously at the same rate in every meristem (dV); floral transition and floral commitment occurred at threshold levels of V; lateral meristems were initiated with a gain of V (ΔV) relative to the V level of the meristem from which they derived. This last rule created a link between successive meristems and gave to the model its zigzag shape. We next exploited the model to explore the diversity of morphotypes that could be generated by varying dV and ΔV and matched them with existing mutant phenotypes. This approach, focused on the development of the primary inflorescence, allowed us to elaborate on the genetic regulation of the kinetic model of inflorescence development. We propose that the lateral inflorescence meristem fate in tomato is closer to an immature flower meristem than to the inflorescence meristem of Arabidopsis. In the last part of our paper, we extend our thought to spatial regulators that should be integrated in a next step for unraveling the relationships between the different meristems that participate to sympodial growth. [less ▲]

Detailed reference viewed: 43 (10 ULg)
Full Text
Peer Reviewed
See detailDetection of Usutu virus in a bullfinch (Pyrrhula pyrrhula) and a great spotted woodpecker (Dendrocopos major) in north-west Europe
Garigliany, Mutien-Marie ULg; Marlier, Didier ULg; Tenner-Racz, Klara et al

in Veterinary Journal (2014), 199

In October 2012, a 3-year-old bullfinch (Pyrrhula pyrrhula) held in captivity for its entire lifespan and a wild adult great spotted woodpecker (Dendrocopos major), both with neurological signs, were ... [more ▼]

In October 2012, a 3-year-old bullfinch (Pyrrhula pyrrhula) held in captivity for its entire lifespan and a wild adult great spotted woodpecker (Dendrocopos major), both with neurological signs, were found 4 km from each other and 5 days apart in the Meuse Valley, Belgium. Non-suppurative encephalitis and mild degeneration and necrosis were identified in the brain and cerebellum, and Usutu virus antigen and RNA were detected by immunohistochemistry and real-time reverse transcriptase PCR, respectively. The two cases reported here represent the most western distribution of clinical disease in birds due to Usutu virus. [less ▲]

Detailed reference viewed: 67 (35 ULg)
Full Text
Peer Reviewed
See detailDeterminants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.
Voilliot, Damien; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014)

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the ... [more ▼]

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. METHODS AND RESULTS: We prospectively enrolled 63 patients with SSc (age 54+/-3years, 76% female) followed in CHU Sart-Tilman in Liege. All patients underwent graded semi-supine exercise echocardiography. Systolic pulmonary arterial pressure (sPAP) was derived from the peak velocity of the tricuspid regurgitation jet and adding the estimation of right atrial pressure, both at rest and during exercise. Resting pulmonary arterial hypertension (PH) was defined as sPAP >35mmHg and EIPH as sPAP >50mmHg during exercise. The following formulas were used: mean PAP (mPAP)=0.61xsPAP+2, left atrial pressure (LAP)=1.9+1.24xleft ventricular (LV) E/e' and pulmonary vascular resistance (PVR)=(mPAP-LAP)/LV cardiac output (CO) and slope of mPAP-LVCO relationship=changes in mPAP/changes in LVCO. Resting PH was present in 3 patients (7%) and 21 patients developed EIPH (47%). Patients with EIPH had higher resting LAP (10.3+/-2.2 versus 8.8+/-2.3mmHg; p=0.03), resting PVR (2.6+/-0.8 vs. 1.4+/-1.1Woods units; p=0.004), exercise LAP (13.3+/-2.3 vs. 9+/-1.7mmHg; p<0.0001), exercise PVR (3.6+/-0.7 vs. 2.1+/-0.9 Woods units; p=0.02) and slope of mPAP-LVCO (5.8+/-2.4 vs. 2.9+/-2.1mmHg/L/min; p<0.0001). After adjustment for age and gender, exercise LAP (beta=3.1+/-0.8; p=0.001) and exercise PVR (beta=7.9+/-1.7; p=0.0001) were independent determinants of exercise sPAP. CONCLUSION: EIPH is frequent in SSc patients and is mainly related to both increased exercise LV filling pressure and exercise PVR. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailIsolation and identification of dominant osmophilic Leuconostoc strains from traditional date product “Btana”
Abekhti, Abdelkader; Daube, Georges ULg; Kihal, M.

in International Food Research Journal [=IFRJ] (2014), 21(4), 1261-1268

The current study aimed to isolate and identify dominant osmophilic bacteria associated with a traditional date product named “Btana”, produced in south region of Maghreb countries. Samples were randomly ... [more ▼]

The current study aimed to isolate and identify dominant osmophilic bacteria associated with a traditional date product named “Btana”, produced in south region of Maghreb countries. Samples were randomly collected after two month of storage from tow villages (Mtarfat and Abani) in the Algerian southern department “Adrar”. A high osmotic pressure medium (MSE) was used for isolation of osmophilic bacteria, which were purified and examined for macroscopic and microscopic shape, Gram stain, catatalse, oxydase, acetoine and ADH production, reduction of nitrate, and motility. Isolates were then subculture on MRS medium for production of dextran, gas from glucose, growth in the presence of NaCl (3, 6.5 %) and sucrose (10, 20, 30, 40, and 50 %), pH tolerance (4.8, 6.5), growth temperature (10, 37, and 45°C) and thermo resistance (55°C for 15 min), enzymatic activity (proteolytic, lipolytic, hemolysis). Isolates were identified to specie’s level by sugar fermentation. Their growth and acidification kinetic were also studied. Results identified two species of Leuconostoc; Leuconostoc mesenteroides subsp. mesenteroides and Leuconostoc mesenteroides subsp. dextranicum. They show a high antibacterial activity against four indicator bacteria; Pseudomonas aeruginosa ATCC 27853, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. [less ▲]

Detailed reference viewed: 44 (0 ULg)
Full Text
Peer Reviewed
See detailComparative study of volatile secondary metabolite of Cistus libanotis during different process
Zidane, H.; Fauconnier, Marie-Laure ULg; Sindic, Marianne ULg et al

in Journal of Chemical and Pharmaceutical Research (2014), 6(8), 281-287

Chemical composition of the essential oils of Cistus libanotis from eastern Morocco (Tafoughalt and Jerrada) extracted from different season was analyzed by GC-MS and GC-FID. The hydro-distilled essential ... [more ▼]

Chemical composition of the essential oils of Cistus libanotis from eastern Morocco (Tafoughalt and Jerrada) extracted from different season was analyzed by GC-MS and GC-FID. The hydro-distilled essential oil content ranged from 0, 27 % to 0, 46%, the maximum amounts were observed in summer while minimum in winter for Tafoughalt, whereas the oil obtained from Jerrada had the highest yield (0, 61 %). The essential oils consisted of terpineol-4 as the most abundant component (18, 70 % - 24, 91 %), followed by γ-terpinene (9, 82 % - 12, 25 %), camphene (5, 86 % - 13, 58 %), sabinene (7, 86 % - 9, 89 %) and α-thujene (6, 92 % - 10, 12 %). Samples collected in all seasons were found to be richer in monoterpenes hydrocarbons (52, 68 % - 57, 59 %). None sesquiterpene hydrocarbons found in the oils from summer and autumn. Drying period of leaves at normal air laboratory and distillation time also affect the oil content and composition. There was variation in terpineol-4 content from 22, 23 % (4th day of drying) to 19, 27 % (29th day of drying), and from 35, 60 % (1 hour of distillation) to 24, 17 % (4 hours of distillation). It can be concluded that the harvesting season, period of drying and the time of distillation had an effect on the yield of essential oil and chemical composition of various compounds. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailSkin viscoelasticity in incipient gravitational syndrome.
Pierard, Gérald ULg; Paquet, Philippe; Pierard-Franchimont, Claudine ULg

in Journal of cosmetic dermatology (2014), 13(1), 52-5

BACKGROUND: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are ... [more ▼]

BACKGROUND: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are altered. AIMS: To assess incipient gravitational edema due to chronic venous insufficiency using measurements of the skin tensile strength. METHOD: A total of 21 women aged 28-37 years were enrolled in the study. Evaluations were made twice in each subject following an alternate use and avoidance of daytime elastic contention. Skin viscoelasticity was measured on the mid portion of the calves using a computerized suction device. RESULTS: The discretely increased consistency of skin showing abnormal rheological characteristics at the site of incipient gravitational edema was significantly improved by contention therapy. Under progressive suction measurements, both skin distensibility, biologic elasticity and hysteresis were increased after wearing tight stockings. The biologic elasticity appears to be the most sensitive parameter pointing to the diagnosis of gravitational syndrome. CONCLUSION: Noninvasive measurements of the skin viscoelasticity, particularly the biologic elasticity, represent an objective assessment of both early gravitational edema and its control by contention therapy. [less ▲]

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailComparison of a Fluid and a Solid Approach for the Numerical Simulation of Friction Stir Welding with a Non‐Cylindrical Pin
Bussetta, Philippe ULg; Dialami, Narges; Boman, Romain ULg et al

in Steel Research International (2014), 85(6), 968-979

Friction stir welding (FSW) process is a solid‐state joining process during which materials to be joined are not melted. As a consequence, the heat‐affected zone is smaller and the quality of the weld is ... [more ▼]

Friction stir welding (FSW) process is a solid‐state joining process during which materials to be joined are not melted. As a consequence, the heat‐affected zone is smaller and the quality of the weld is better with respect to more classical welding processes. Because of extremely high strains in the neighborhood of the tool, classical numerical simulation techniques have to be extended in order to track the correct material deformations. The Arbitrary Lagrangian–Eulerian (ALE) formulation is used to preserve a good mesh quality throughout the computation. With this formulation, the mesh displacement is independent from the material displacement. Moreover, some advanced numerical techniques such as remeshing or a special computation of transition interface is needed to take into account non‐cylindrical tools. During the FSW process, the behavior of the material in the neighborhood of the tool is at the interface between solid mechanics and fluid mechanics. Consequently, a numerical model of the FSW process based on a solid formulation is compared to another one based on a fluid formulation. It is shown that these two formulations essentially deliver the same results in terms of pressures and temperatures. [less ▲]

Detailed reference viewed: 24 (6 ULg)
Full Text
Peer Reviewed
See detailRelationship between glucose and pancreatic hormones during the embryonic and postnatal phase in chickens
Franssens, L.; Buyse, J.; Decuypere, E. et al

in Avian Biology Research (2014), 7

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailVisible-light photo-activity of alkali metal doped ZnO
Benhebal, Hadj; Chaib, Messaoud; Malengreaux, Charline ULg et al

in Journal of the Taiwan Institute of Chemical Engineers (2014), 45(1), 249-253

In order to utilize visible light more efficiently in the field of photocatalysis, Li, Na and K-doped ZnO nanoparticles were prepared using a sol–gel method. The obtained samples were characterized by BET ... [more ▼]

In order to utilize visible light more efficiently in the field of photocatalysis, Li, Na and K-doped ZnO nanoparticles were prepared using a sol–gel method. The obtained samples were characterized by BET surface area measurements, X-ray diffraction, scanning electron microscopy and UV–vis analysis. The photocatalytic activity of the photocatalysts was evaluated for the degradation of p-nitrophenol (p-NP) under visible light irradiation. It has been observed that these photocatalysts could be a promising photocatalyst for degradation of organic molecules as compared to transition metal doped ZnO under visible light. Li-doped ZnO is the most active photocatalyst and shows high photocatalytic activity for the degradation of p-nitrophenol (p-NP). The enhanced photocatalytic activity of Li-doped ZnO is mainly due to the electron trapping by lithium metal ions, small particle size, large surface area, and high surface roughness of the photocatalysts. [less ▲]

Detailed reference viewed: 70 (12 ULg)
Full Text
Peer Reviewed
See detailMarcos, la botarga. ¿Avatar o despedida del Subcomandante?
Vanden Berghe, Kristine ULg

in Asociación para el Fomento de los Estudios Históricos en Centroamérica (2014), 60

Se evalúa hasta qué punto la despedida del Sucomandante Marcos en mayo de 2014 se inscribe en la continuación de un discurso anterior o se desvía de él.

Detailed reference viewed: 13 (5 ULg)
Full Text
Peer Reviewed
See detailPopular Economy in Santiago de Chile: State of Affairs and Challenges
Bauwens, Thomas ULg; Lemaître, Andreia

in World Development : The Multi-Disciplinary International Journal Devoted to the Study and Promotion of World Development (2014), 64

Do informal initiatives share a capitalist spirit of entrepreneurship? This article attempts to answer this question, using a “popular economy” analytical framework and focusing on the case of Chile ... [more ▼]

Do informal initiatives share a capitalist spirit of entrepreneurship? This article attempts to answer this question, using a “popular economy” analytical framework and focusing on the case of Chile. First, we present the context of the research, namely the economic and political evolutions in Chile since the 1970s and their effects on the popular economy. Then, we seek to answer the original question, relying on in-depth case studies of so-called “popular economy organizations”. Our research shows that their socio-economic logics significantly differ from those of the traditional capitalist firm. Our observations also suggest important differences between current and older initiatives. [less ▲]

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailFunctional adaptations of the bacterial chaperone trigger factor to extreme environmental temperatures
Godin-Roulling, Amandine ULg; Schmidpeter, P.A.M.; Schmid, F.X. et al

in Environmental Microbiology (2014)

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailLes modifications du fonctionnement exécutif dans le vieillissement normal
Collette, Fabienne ULg; Salmon, Eric ULg

in Psychologie Française (2014), 59(1), 41-58

Il est maintenu bien reconnu que le vieillissement cognitif est associé à une diminution des capacités exécutives. Toutefois, si des déficits sont effectivement observés au sein des différentes fonctions ... [more ▼]

Il est maintenu bien reconnu que le vieillissement cognitif est associé à une diminution des capacités exécutives. Toutefois, si des déficits sont effectivement observés au sein des différentes fonctions, des dissociations entre performances préservées/altérées ont également été observées au sein de chacune. Dans cette revue de question, nous détaillerons les effets du vieillissement dans les fonctions de mise à jour, flexibilité, inhibition et coordination de tâches doubles, ainsi que les modifications au sein des réseaux cérébraux associés à ces processus. Nous discuterons également l'influence des capacités attentionnelles, des ressources en mémoire de travail et de certaines caractéristiques génétiques sur ces modifications. [less ▲]

Detailed reference viewed: 159 (20 ULg)
Full Text
Peer Reviewed
See detailComment definir une circulation extracorporelle de qualite ?
Blaffart, F.; Defraigne, Jean-Olivier ULg

in Annales francaises d'anesthesie et de reanimation (2014)

Extracorporeal circulation (ECC) has to ensure homeostasis of the patient and to minimize pathophysiological disorders inherent in the technique. However, we cannot dissociate it from the surgery and ... [more ▼]

Extracorporeal circulation (ECC) has to ensure homeostasis of the patient and to minimize pathophysiological disorders inherent in the technique. However, we cannot dissociate it from the surgery and anesthesia knowing that the discipline involves a close partnership with these stakeholders. The purpose of this publication is to review the essential elements that at present can contribute to the quality of the CEC and suggest improvements and developments to be implemented in this area. [less ▲]

Detailed reference viewed: 47 (0 ULg)
Full Text
Peer Reviewed
See detailInmanencia y empirismo. Examen epistemológico de la teoría del lenguaje de Louis Hjelmslev
Badir, Sémir ULg

in Topicos del Seminario (2014), 31

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailObituary Ivan Impens (1935-2014). Poor is the disciple who does not surpass his master
Bogaert, Jan ULg; Nijs, I; Ceulemans, R

in Tropicultura (2014), 32(1), 110-111

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailReview of Postcolonial Ecologies: Literatures of the Environment edited by Elizabeth DeLoughrey and George B. Handley
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2014), 88(1-2), 182-184

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailLow temperature crystallization of yttrium orthoferrite by organic acid-assisted sol-gel synthesis
Stevens, Frédéric ULg; Cloots, Rudi ULg; Poelman, D. et al

in Materials Letters (2014), 114

Yttrium orthoferrite (YFeO3) is a promising material for visible light photocatalytic applications due to its band gap of 2.2-2.6 eV. However, during the synthesis of YFeO3, unwanted composition can be ... [more ▼]

Yttrium orthoferrite (YFeO3) is a promising material for visible light photocatalytic applications due to its band gap of 2.2-2.6 eV. However, during the synthesis of YFeO3, unwanted composition can be obtained and the crystallization requires temperatures as high as 850 C. Powders of YFeO3 were prepared using a sol-gel method with and without organic acids (citric acid, tartaric acid, malonic acid and oxalic acid) used as organic modifiers. The band gap of these powders was measured by diffuse reflection spectroscopy, and the crystallinity and crystalline phase content were characterized by X-ray diffraction. Organic acids allow a higher purity and facilitate crystallization. This work aims to produce YFeO3 powders at the lowest possible temperature. Citric acid was found to be the best additive: it reduces the crystallization temperature below 450 C. This opens new perspectives such as the deposition of crystalline YFeO3 thin films onto conductive glass for water-splitting applications. © 2013 Elsevier B.V. [less ▲]

Detailed reference viewed: 44 (10 ULg)
Full Text
Peer Reviewed
See detailSex Differences in Abdominal Aortic Aneurysm: the Role of Sex Hormones.
Makrygiannis, Georgios ULg; Courtois, Audrey ULg; Drion, Pierre ULg et al

in Annals of vascular surgery (2014)

Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in males, whereas women have a greater risk of rupture and more frequently ... [more ▼]

Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in males, whereas women have a greater risk of rupture and more frequently have concomitant thoracic aortic aneurysms. Moreover, women are diagnosed with AAA about 10 years later and seem to be protected by female sex hormones. In this MEDLINE-based review of literature we examined human and animal, in vivo and in vitro studies, to further deepen our understanding of the sexual dimorphism of AAA. We focus on the role of sex hormones during the formation and growth of AAA. Endogenous estrogens and exogenous 17beta-estradiol were found to exert favorable actions protecting from AAA in animal models, whereas exogenous hormone replacement therapy in humans had inconclusive results. Androgens, known to have detrimental effects in the vasculature, in sufficient levels maintain the integrity of the aortic wall through their anabolic actions and act differentially in males and females, whereas lower levels of testosterone have been associated with AAA in humans. In conclusion, sex differences remain an important area of AAA research, but further studies especially in humans are needed. Furthermore, differential molecular mechanisms of sex hormones constitute a potential therapeutic target for AAA. [less ▲]

Detailed reference viewed: 37 (27 ULg)
Full Text
Peer Reviewed
See detailImportance of LUC and ILUC on the carbon footprint of bioproduct: case of bio-HDPE
Belboom, Sandra ULg; Léonard, Angélique ULg

in Matériaux et Techniques (2014), 102(2),

Suite à la diminution des ressources fossiles et à l’augmentation des émissions des gaz à effet de serre, des solutions sont nécessaires pour remplacer les produits issus du pétrole. Cela a pour ... [more ▼]

Suite à la diminution des ressources fossiles et à l’augmentation des émissions des gaz à effet de serre, des solutions sont nécessaires pour remplacer les produits issus du pétrole. Cela a pour conséquence une constante augmentation du nombre de produits biobasés développés à partir de ressources agricoles. Cette étude évalue l’empreinte carbone du polyéthylène haute densité (PEHD) produit à partir de canne à sucre brésilienne ou de betterave belge. Le but de cette étude est de comparer l’empreinte carbone du bio-PEHD avec le PEHD fossile en considérant l’effet du changement d’affectation des sols. Les frontières communes des systèmes agricoles regroupent l’étape de culture de la canne à sucre et de la betterave, avec toutes les consommations associées d’énergie et d’engrais, le transport depuis le champ jusqu’à l’unité industrielle, la transformation des plantes sucrières en bioéthanol hydraté, la valorisation des sous-produits, la polymérisation et l’incinération du PEHD. Le scénario fossile comprend la production d’éthylène, sa polymérisation et l’incinération du PEHD. La comparaison du cycle de vie entier des PEHD biobasé et fossile montre des émissions de GES plus faibles avec le produit biobasé, ce qui est l’effet voulu. Ce résultat est uniquement valide s’il n’y pas de changement direct ou indirect d’affectation des sols. Pour évaluer l’impact environnemental de la déforestation ou de la transformation d’un pâturage en champ, les lignes directrices de l’Union Européenne ont été suivies afin de calculer les émissions de CO2 en fonction de divers paramètres. Pour la canne à sucre, le changement direct d’affectation des sols (LUC) est défini par la transformation de pâturages en champs dans la région de Sao Paulo au Brésil. Trois scénarios ont été développés, basés sur différentes pratiques agricoles pour les pâturages et les champs (labour et engrais) : le meilleur, le pire et le moyen. Le meilleur cas engendre un gain environnemental supplémentaire pour le produit biobasé. Le pire et le moyen amènent des émissions complémentaires. Un temps de retour, considérant le temps nécessaire pour récupérer à nouveau un gain environnemental comparativement au produit fossile, a été calculé pour le scenario moyen et s’élève à 12 ans. Le changement indirect d’affectation des sols pour la canne à sucre est modélisé comme étant la transformation d’une forêt en champ induite par les effets du changement direct décrit ci-avant. Le taux de déforestation peut varier entre 16 et 100%, dépendant des statistiques utilisées et entrainant un temps de retour de respectivement 26 et 101 ans. Pour la betterave, aucun changement direct n’est considéré. En effet, aucune expansion des terres agricoles ne peut être envisagée en Belgique au vu des faibles surfaces disponibles. Si une augmentation en termes de production de bioplastiques a lieu, la Belgique devra importer de la betterave provenant des pays voisins, ce qui peut induire un changement indirect d’affectation des sols. Dans cette étude, la betterave est supposée provenir des Pays-Bas. Celle-ci est cultivée sur des pâturages préalablement transformés en champs. Ce scénario moyen induit un temps de retour de 8 ans. Cette étude a mis en évidence l’importance du changement direct et indirect d’affectation des sols, spécialement pour les cultures énergétiques dédiées au remplacement des produits fossiles. Cet effet peut renverser les résultats attendus et engendrer de longs temps de retour. [less ▲]

Detailed reference viewed: 26 (5 ULg)
Full Text
Peer Reviewed
See detailGeometric ferroelectricity in fluoroperovskites
Garcia-Castro, A. C.; Spaldin, Nicola A.; Romero, A. H. et al

in Physical Review B (2014), 89

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are ... [more ▼]

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are paraelectric (Pnma phase), we find that many fluoroperovskites have a ferroelectric instability in their high-symmetry cubic structure that is of similar amplitude to that commonly found in oxide perovskites. In contrast to the oxides, however, the fluorides have nominal Born effective charges, indicating a different mechanism for the instability.We show that the instability originates from ionic size effects, and is therefore in most cases largely insensitive to pressure and strain, again in contrast to the oxide perovskites. An exception is NaMnF3, where coherent epitaxial strain matching to a substrate with equal in-plane lattice constants destabilizes the bulk Pnma structure, leading to a ferroelectric, and indeed multiferroic, ground state with an unusual polarization/strain response. [less ▲]

Detailed reference viewed: 42 (13 ULg)
Full Text
Peer Reviewed
See detailA Novel Strategy to Translate the Biomechanical Rupture Risk of Abdominal Aortic Aneurysms to their Equivalent Diameter Risk: Method and Retrospective Validation.
Gasser, T. C.; Nchimi, A.; Swedenborg, J. et al

in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2014)

OBJECTIVE: To translate the individual abdominal aortic aneurysm (AAA) patient's biomechanical rupture risk profile to risk-equivalent diameters, and to retrospectively test their predictability in ... [more ▼]

OBJECTIVE: To translate the individual abdominal aortic aneurysm (AAA) patient's biomechanical rupture risk profile to risk-equivalent diameters, and to retrospectively test their predictability in ruptured and non-ruptured aneurysms. METHODS: Biomechanical parameters of ruptured and non-ruptured AAAs were retrospectively evaluated in a multicenter study. General patient data and high resolution computer tomography angiography (CTA) images from 203 non-ruptured and 40 ruptured aneurysmal infrarenal aortas. Three-dimensional AAA geometries were semi-automatically derived from CTA images. Finite element (FE) models were used to predict peak wall stress (PWS) and peak wall rupture index (PWRI) according to the individual anatomy, gender, blood pressure, intra-luminal thrombus (ILT) morphology, and relative aneurysm expansion. Average PWS diameter and PWRI diameter responses were evaluated, which allowed for the PWS equivalent and PWRI equivalent diameters for any individual aneurysm to be defined. RESULTS: PWS increased linearly and PWRI exponentially with respect to maximum AAA diameter. A size-adjusted analysis showed that PWS equivalent and PWRI equivalent diameters were increased by 7.5 mm (p = .013) and 14.0 mm (p < .001) in ruptured cases when compared to non-ruptured controls, respectively. In non-ruptured cases the PWRI equivalent diameters were increased by 13.2 mm (p < .001) in females when compared with males. CONCLUSIONS: Biomechanical parameters like PWS and PWRI allow for a highly individualized analysis by integrating factors that influence the risk of AAA rupture like geometry (degree of asymmetry, ILT morphology, etc.) and patient characteristics (gender, family history, blood pressure, etc.). PWRI and the reported annual risk of rupture increase similarly with the diameter. PWRI equivalent diameter expresses the PWRI through the diameter of the average AAA that has the same PWRI, i.e. is at the same biomechanical risk of rupture. Consequently, PWRI equivalent diameter facilitates a straightforward interpretation of biomechanical analysis and connects to diameter-based guidelines for AAA repair indication. PWRI equivalent diameter reflects an additional diagnostic parameter that may provide more accurate clinical data for AAA repair indication. [less ▲]

Detailed reference viewed: 18 (8 ULg)
Full Text
Peer Reviewed
See detailExternal constraints on optical control strategies in molecular orientation and photofragmentation: role of zero-area fields
Sugny, Dominique; Vranckx, Stéphane; Ndong, Mamadou et al

in Journal of Modern Optics (2014), 61

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailIn Vitro and In Vivo Antiplasmodial Activity of Three Rwandan Medicinal Plants and Identification of Their Active Compounds
Muganga, Raymond; Angenot, Luc ULg; Tits, Monique ULg et al

in Planta Medica (2014), 80(6), 482-489

In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwandan plant extracts. This gave rise to the need for these extracts to also be evaluated in vivo and to ... [more ▼]

In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwandan plant extracts. This gave rise to the need for these extracts to also be evaluated in vivo and to identify the compounds responsible for their antiplasmodial activity. The aim of our study was, on the one hand, to evaluate the antiplasmodial activity in vivo and the safety of the selected Rwandan medicinal plants used in the treatment of malaria, with the objective of promoting the development of improved traditional medicines and, on the other hand, to identify the active ingredients in the plants. Plant extracts were selected according to their selectivity index. The in vivo antiplasmodial activity of aqueous, methanolic, and dichloromethane extracts was then evaluated using the classical 4-day suppressive test on Plasmodium berghei infected mice. The activity of the plant extracts was estimated by measuring the percentage of parasitemia reduction, and the survival of the experimental animals was recorded. A bioguided fractionation was performed for the most promising plants, in terms of antiplasmodial activity, in order to isolate active compounds identified by means of spectroscopic and spectrometric methods. The highest level of antiplasmodial activity was observed with the methanolic extract of Fuerstia africana (> 70 %) on days 4 and 7 post-treatment after intraperitoneal injection and on day 7 using oral administration. After oral administration, the level of parasitemia reduction observed on day 4 post-infection was 44 % and 37 % with the aqueous extract of Terminalia mollis and Zanthoxylum chalybeum, respectively. However, the Z. chalybeum extract presented a high level of toxicity after intraperitoneal injection, with no animals surviving on day 1 post-treatment. F. africana, on the other hand, was safer with 40 % mouse survival on day 20 post-treatment. Ferruginol is already known as the active ingredient in F. Africana, and ellagic acid (IC50 = 175 ng/mL) and nitidine (IC50 = 77.5 ng/mL) were identified as the main active constituents of T. mollis and Z. chalybeum, respectively. F. africana presented very promising antiplasmodial activity in vivo. Although most of the plants tested showed some level of antiplasmodial activity, some of these plants may be toxic. This study revealed for the first time the role of ellagic acid and nitidine as the main antimalarial compounds in T. mollis and Z. chalybeum, respectively. [less ▲]

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailEXPLORATION ET TRAITEMENT D’UN CARCINOME EPIDERMOIDE GANGLIONNAIRE CERVICAL SANS PRIMITIF DECELE
WERENNE, Xavier ULg; SAUTOIS, Brieuc ULg; DEMEZ, Pierre ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 58-62

A l’heure actuelle, le bilan à réaliser après décou - verte d’une adénopathie cervicale est bien codifié. Le PET- scan, dans un premier temps controversé, s’affirme étude après étude comme un élément ... [more ▼]

A l’heure actuelle, le bilan à réaliser après décou - verte d’une adénopathie cervicale est bien codifié. Le PET- scan, dans un premier temps controversé, s’affirme étude après étude comme un élément essentiel. La stratégie de traitement pratiquée dans la plupart des centres consiste en un évidemment cervical suivi de radiothérapie portant sur les muqueuses pharyngées ainsi que sur les relais ganglion - naires cervicaux bilatéraux avec éventuelle association à une chimiothérapie. Celle-ci est ajoutée en fonction de facteurs anatomo-pathologiques de mauvais pronostic, mais elle n’a pas fait la preuve de sa supériorité. De multiples études de phase II aboutissent d’ailleurs à des conclusions opposées. En dehors de données issues d’études randomisées, le traitement aujourd’hui se décide par analogie à ceux qui sont appliqués lorsque le site primitif tumoral est identifié dans la sphère ORL. [less ▲]

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailReview of: D. Zahavi (ed.), The Oxford Handbook of Contemporary Phenomenology (Oxford, 2012)
Seron, Denis ULg

in Husserl Studies (2014), 30(2), 277-281

Detailed reference viewed: 31 (8 ULg)
Full Text
Peer Reviewed
See detailA note on abelian returns in rotation words
Rampersad, Narad; Rigo, Michel ULg; Salimov, Pavel ULg

in Theoretical Computer Science (2014), 528

Pursuing the study started by Rigo, Salimov and Vandomme, we use elementary number-theoretic techniques to characterize rotation words having a finite set of abelian returns to all prefixes. We also make ... [more ▼]

Pursuing the study started by Rigo, Salimov and Vandomme, we use elementary number-theoretic techniques to characterize rotation words having a finite set of abelian returns to all prefixes. We also make the connection between the three gap theorem and the number of semi-abelian returns for Sturmian words, simplifying some arguments developed by Puzynina and Zamboni. [less ▲]

Detailed reference viewed: 76 (11 ULg)
Full Text
Peer Reviewed
See detailJupiter's Magnetotail
Krupp, Norbert; Kronberg, Elena; Radioti, Aikaterini ULg

in AGU Monograph (2014)

Detailed reference viewed: 13 (4 ULg)
Full Text
Peer Reviewed
See detailMyeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis.
Nzeusseu Toukap, A.; Delporte, C.; Noyon, C. et al

in Free radical research (2014), 48(4), 461-5

Abstract Objective. Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is ... [more ▼]

Abstract Objective. Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is a link between oxidative stress and cytokines. The present study aims at investigating the link between synovial MPO (and its products), interleukin (IL)-18, which is involved in the degradation of articular cartilage in RA, and IL-8, which is involved in recruitment and activation of neutrophils during inflammation. Effects of the treatment of RA on the biological parameters were also investigated. Methods. Patients (n = 105) were studied including 39 patients with OA, 33 with RA and 33 with RA receiving a specific treatment. Disease activity score (DAS-28) was calculated whereas MPO antigen/activity, neutrophils, chloro-tyrosine (Cl-Tyr), homocitrulline (Hcit), IL-8, and IL-18 were measured in synovial fluid (SF) and CRP was measured in serum. Results. DAS-28 and CRP levels were not significantly different between groups. MPO activity, and MPO, Cl-Tyr, and Hcit levels were significantly higher in SF of RA patients than OA patients. MPO specific activity (MPO activity/antigen ratio) was significantly lower in treated than in untreated RA patients as was IL-8. MPO activity and concentration were correlated with IL-8 and IL-18 in untreated but not in treated RA patients. Conclusions. MPO level is related to IL-8 and IL-18 levels in untreated RA patients. A link has been shown between treatment and decrease of IL-8, MPO specific activity and Hcit in SF. The causal role of MPO in SF inflammation and how treatment can affect MPO specific activity need further investigations. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailThe peasants in turmoil: Khmer Rouge, state formation and the control of land in northwest Cambodia
Diepart, Jean-Christophe ULg; Dupuis, David

in The Journal of Peasant Studies (2014), 41(4), 445468

Over the past 15 years, northwest Cambodia has seen dramatic agrarian expansion away from the central rice plain into the peripheral uplands fuelled by peasant in-migration. Against this background, we ... [more ▼]

Over the past 15 years, northwest Cambodia has seen dramatic agrarian expansion away from the central rice plain into the peripheral uplands fuelled by peasant in-migration. Against this background, we examine the nature of relations between the peasantry and the state. We first show the historical continuities of land control processes and how the use of violence in a post-conflict neoliberal context has legitimised ex-Khmer Rouge in controlling land distribution. Three case studies show the heterogeneity of local level sovereignties, which engage the peasants in different relations with authority. We examine how these processes result in the construction of different rural territories along the agricultural frontier and argue that, in this region of Cambodia, the struggles between Khmer Rouge and neoliberal modes of land control are central to state formation processes. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailIdentification of pregnancy-associated glycoproteins and alpha-fetoprotein in fallow deer (Dama dama) placenta
Bériot, Mathilde ULg; Tchimbou Njanjo, Aline Flora ULg; Barbato, Olimpia et al

in Acta Veterinaria Scandinavica (2014), 56(4), 1-11

Background: This paper describes the isolation and characterization of pregnancy-associated glycoproteins (PAG) from fetal cotyledonary tissue (FCT) and maternal caruncular tissue (MCT) collected from ... [more ▼]

Background: This paper describes the isolation and characterization of pregnancy-associated glycoproteins (PAG) from fetal cotyledonary tissue (FCT) and maternal caruncular tissue (MCT) collected from fallow deer (Dama dama) pregnant females. Proteins issued from FCT and MCT were submitted to affinity chromatographies by using Vicia villosa agarose (VVA) or anti-bovine PAG-2 (R#438) coupled to Sepharose 4B gel. Finally, they were characterized by SDSPAGE and N-terminal microsequencing. Results: Four distinct fallow deer PAG (fdPAG) sequences were identified and submitted to Swiss-Prot database. Comparison of fdPAG with PAG sequences identified in other ruminant species exhibited 64 to 83% identity. Additionally, alpha-fetoprotein was identified in fetal and maternal tissues. Conclusion: Our results demonstrate the efficacy of VVA and bovine PAG-2 affinity chromatographies for the isolation of PAG molecules expressed in deer placenta. This is the first report giving four specific amino acid sequences of PAG isolated from feto-maternal junction (FCT and MCT) in the Cervidae family. [less ▲]

Detailed reference viewed: 24 (3 ULg)
Full Text
Peer Reviewed
See detailEffect of land use on pollution status and risk of fish endocrine disruption in small farmland ponds
Mandiki; Gillardin; Martens et al

in Hydrobiologia (2014), 723

Detailed reference viewed: 22 (4 ULg)
Full Text
See detailVie, langage, matérialité: les stratégies de civilité du cinéma de Kechiche
Janvier, Antoine ULg

in Cahiers du GRM (2014), 5

Partant d'une analyse des quatre premiers films de Kechiche, en particulier de "La faute à Voltaire", "L’esquive" et "La graine et le mulet", ce texte s'efforce de penser les modalités et les conséquences ... [more ▼]

Partant d'une analyse des quatre premiers films de Kechiche, en particulier de "La faute à Voltaire", "L’esquive" et "La graine et le mulet", ce texte s'efforce de penser les modalités et les conséquences du traitement cinématographique proposé par Abdellatif Kechiche de la vie ou de l’existence humaine depuis le problème que pose leur limite. On verra qu’il y va d’une certaine conception et perception de la violence, et d’une exploration soutenue et attentive de l’épaisseur affective, proto- ou para-politique, de nos formations sociales. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailcomment j'explore les infections nosocomiales en néonatologie
Dachy, Angélique ULg; Battisti, Oreste ULg

in Revue Médicale de Liège (2014)

Detailed reference viewed: 32 (1 ULg)