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See detailNarrowing the science/policy gap for environmental management
Hughes, Kevin A; Liggett, Daniela; Roldan, Gabriela et al

in Antarctic Science (2016), 28(5), 325

Antarctic terrestrial and marine environments are under increasing pressure from national operator activities, tourism and climate change. The Protocol on Environmental Protection to the Antarctic Treaty ... [more ▼]

Antarctic terrestrial and marine environments are under increasing pressure from national operator activities, tourism and climate change. The Protocol on Environmental Protection to the Antarctic Treaty provides overarching legislation concerning the environmental management of the Treaty area, with 2016 marking the Protocol’s 25th anniversary. The Protocol also established the Committee for Environmental Protection (CEP) to provide advice to the Antarctic Treaty Consultative Meeting (ATCM) on environmental matters. Today, the CEP’s Five-Year Work Plan and Climate Change Response Work Programme lists and prioritises issues that need to be addressed to ensure impacts in Antarctica by human activities are both recognized andminimised.Despite all of this, recent evaluations have suggested that a slow pace of environmental policy development presents a significant threat to effective Antarctic conservation. Progress on many environmental issues, including wildlife disturbance, the conservation status of Antarctic species, area protection and pollution management, is glacial or has stalled completely. Whilst in some cases capacity issues concerning those responsible for Antarctic environmental policy work may be a contributing factor, the level of interaction between researchers and those responsible for environmental management and decision-making is also of importance. Without quality science - and effective interpretation of research results - policymakers have little evidence on which to base their decisions. But researchers need to know policymakers’ needs. Two-way communication is essential: policymakers could ask the research community to answer specific environmental questions, and, in turn, researchers could present evidence-based recommendations and highlight emerging threats. But how is this to be funded? Ultimately, effective communication is needed between national government departments responsible for funding Antarctic research and those dealing with Antarctic environmental protection. Hopefully, this will ensure essential research informing environmental policy decisions is adequately resourced. In reality, the cost is likely to be trivial compared with the resources spent by Parties on Antarctic logistics. [less ▲]

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See detailCollaborative Care regarding major depressed patients: A review of guidelines and current practices
Van den Broeck, Kris; Remmen, Roy; Vanmeerbeek, Marc ULg et al

in Journal of Affective Disorders (2016), 200

Major Depressive Disorder (MDD) is a severe and common mental disorder. A growing body of evidence suggests that stepped and/or collaborative care treatment models have several advantages for severely ... [more ▼]

Major Depressive Disorder (MDD) is a severe and common mental disorder. A growing body of evidence suggests that stepped and/or collaborative care treatment models have several advantages for severely depressed patients and caretakers. However, despite the availability of these treatment strategies and guidance initiatives, many depressive patients are solely treated by the general practitioner (GP), and collaborative care is not common. In this paper, we review a selected set of international guidelines to inventory the best strategies for GPs and secondary mental health care providers to collaborate when treating depressed patients. Additionally, we systematically searched the literature, listing potential ways of cooperation, and potentially supporting tools. We conclude that the prevailing guidelines only include few and rather vague directions regarding the cooperation between GPs and specialised mental health practitioners. Inspiring recent studies, however, suggest that relatively little efforts may result in effective collaborative care and a broader implementation of the guidelines in general. [less ▲]

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See detailRelationship between frailty, physical performance and quality of life among nursing home residents: the SENIOR cohort
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Petermans, Jean ULg et al

in Aging Clinical and Experimental Research (2016), Epub ahead of print

Background The aim of this study was to assess the relationship between frailty and a large number of indicators related to physical and muscular performance as well as quality of life. Methods This is an ... [more ▼]

Background The aim of this study was to assess the relationship between frailty and a large number of indicators related to physical and muscular performance as well as quality of life. Methods This is an analysis of data collected at baseline in the Sample of Elderly Nursing home Individuals: an Observational Research (SENIOR) cohort including nursing home residents. Subjects are volunteer, oriented and able to walk (walking assistance allowed) nursing home residents in Belgium. A large number of demographic and clinical characteristics, including physical and muscular performance, were collected from each patient. The prevalence of frailty in this population was assessed using Fried’s definition. Results In total, 662 subjects are included in this analysis. The mean age of the sample is 83.2 ± 8.99 years, and 484 (73.1 %) are women. In this population of nursing home residents, the prevalence of frailty is 25.1 %, pre-frailty, 59.8 % and robustness, 15.1 %. Compared to non-frail subjects, frail subjects have lower physical and muscular performances and a lower quality of life. Conclusion Frailty, according to Fried’s definition, seems to be associated with several clinical indicators suggesting a higher level of disability and an increased propensity to develop major clinical consequences. Follow-up data of the SENIOR cohort will be helpful in confirming these findings, establishing cause–effect relationships and identifying the most predictive components of physical frailty for adverse outcomes in nursing homes. [less ▲]

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See detailForecasting travel behavior using Markov Chains-based approaches
Saadi, Ismaïl ULg; El Saeid Mustafa, Ahmed Mohamed ULg; Teller, Jacques ULg et al

in Transportation Research. Part C : Emerging Technologies (2016), 69

Recent advances in agent-based micro-simulation modeling have further highlighted the importance of a thorough full synthetic population procedure for guaranteeing the correct characterization of real ... [more ▼]

Recent advances in agent-based micro-simulation modeling have further highlighted the importance of a thorough full synthetic population procedure for guaranteeing the correct characterization of real-world populations and underlying travel demands. In this regard, we propose an integrated approach including Markov Chain Monte Carlo (MCMC) simulation and profiling-based methods to capture the behavioral complexity and the great heterogeneity of agents of the true population through representative micro-samples. The population synthesis method is capable of building the joint distribution of a given population with its corresponding marginal distributions using either full or partial conditional probabilities or both of them simultaneously. In particular, the estimation of socio-demographic or transport-related variables and the characterization of daily activity-travel patterns are included within the framework. The fully probabilistic structure based on Markov Chains characterizing this framework makes it innovative compared to standard activity-based models. Moreover, data stemming from the 2010 Belgian Household Daily Travel Survey (BELDAM) are used to calibrate the modeling framework. We illustrate that this framework effectively captures the behavioral heterogeneity of travelers. Furthermore, we demonstrate that the proposed framework is adequately adapted to meeting the demand for large-scale micro-simulation scenarios of transportation and urban systems. [less ▲]

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See detailThe future impacts on downstream communities: A case study of the multipurpose Nam Mang 3 hydropower Project in Lao PDR
Kouangpalath, Phimthong ULg; Lebailly, Philippe ULg; Ducourtieux, Olivier

in Sky Journal of Agricultural Research (2016), 5(6), 105-128

Considering future projects, this paper examines the effects of hydropower dam projects on downstream communities. This study was conducted in the multi-purpose hydropower and irrigated areas of the Nam ... [more ▼]

Considering future projects, this paper examines the effects of hydropower dam projects on downstream communities. This study was conducted in the multi-purpose hydropower and irrigated areas of the Nam Mang 3 hydropower. Using a survey study with various stakeholders, household survey, several interviews were held with key informants in addition to field work observation. It was determined that this project has caused a number of negative impacts on farmers, especially those in downstream areas, directly concerned water releases from dam and affecting the benefits from irrigation. The main findings show that farmers are able to grow a second season of rice crops, but the electricity generated in the rainy season from the dam leads to the rice fields flooding along the downstream areas. [less ▲]

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See detailPostmortem Internal Gas Reservoir Monitoring Using GCxGC-HRTOFMS
Stefanuto, Pierre-Hugues ULg; Perrault, Katelynn ULg; Grabher, Silke et al

in separations (2016), 3(24),

Forensic investigations often require postmortem examination of a body. However, the collection of evidence during autopsy is often destructive, meaning that the body can no longer be examined in its ... [more ▼]

Forensic investigations often require postmortem examination of a body. However, the collection of evidence during autopsy is often destructive, meaning that the body can no longer be examined in its original state. In order to obtain an internal image of the body, whole body postmortem computed tomography (PMCT) has proven to be a valuable non-destructive tool and is currently used in medicolegal centers. PMCT can also be used to visually locate gas reservoirs inside a cadaver, which upon analysis can provide useful information regarding very volatile compounds that are produced after death. However, the non-targeted profiling of all potential volatile organic compounds (VOCs) present in these reservoirs has never been attempted. The aim of this study was to investigate the VOC profile of these reservoirs and to evaluate potential uses of such information to document circumstances surrounding death, cause of death and body taphonomy. Comprehensive two-dimensional gas chromatography coupled to time-of-flight high-resolution mass spectrometry (GC GC-HRTOF-MS) was used for VOC measurements. This study demonstrated that the chemical composition of VOCs within the gas reservoirs differed between locations within a single body but also between individuals. In the future, this work could be expanded to investigate a novel, non-destructive cadaver screening approach prior to full autopsy procedures. [less ▲]

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See detailStatistically Bundled Shewhart Control Charts for Monitoring Delivery Chains Systems
Foster, Earnest; Faraz, Alireza ULg; Heuchenne, Cédric ULg

in European Journal of Industrial Engineering (2016)

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the ... [more ▼]

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the proposed method is to provide supply chain decision makers with an easy to be managed tool monitoring the current functioning state of the delivery chain. The implementation of SPC control charts makes it possible to limit over-corrections to false alarm conditions and to maintain at an acceptable level the safety stock, with a consequent reduction of the overall management costs of the delivery chain. An illustrative example shows the proposed control chart implementation in a real delivery chain. [less ▲]

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See detailAnalysing hypoglycin A, methylenecyclopropylacetic acid conjugates and acylcarnitines in blood to confirm the diagnosis and improve our understanding of atypical myopathy
Votion, Dominique ULg

in Equine Veterinary Education (2016), doi: 10.1111/eve.12617

Owing to recent methodological validation studies, we have now the opportunity to determine hypoglycin A, methylenecyclopropylacetic acid–carnitine and acylcarnitines concentrations in equine serum. These ... [more ▼]

Owing to recent methodological validation studies, we have now the opportunity to determine hypoglycin A, methylenecyclopropylacetic acid–carnitine and acylcarnitines concentrations in equine serum. These analytes are essential to confirm the diagnosis of atypical myopathy but also to improve our understanding of the pathophysiology of the disease. In particular, they might help elucidate why some horses seem more resistant to hypoglycin A poisoning. [less ▲]

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See detailLongterm results of liver transplantation from donation after circulatory death.
Blok, Joris J.; DETRY, Olivier ULg; Putter, Hein et al

in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2016), 22(8), 1107-14

Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic-type ... [more ▼]

Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic-type biliary lesions. However, similar survival rates for DCD and donation after brain death (DBD) LT have been reported. The objective of this study is to determine the longterm outcome of DCD LT in the Eurotransplant region corrected for the Eurotransplant donor risk index (ET-DRI). Transplants performed in Belgium and the Netherlands (January 1, 2003 to December 31, 2007) in adult recipients were included. Graft failure was defined as either the date of recipient death or retransplantation whichever occurred first (death-uncensored graft survival). Mean follow-up was 7.2 years. In total, 126 DCD and 1264 DBD LTs were performed. Kaplan-Meier survival analyses showed different graft survival for DBD and DCD at 1 year (77.7% versus 74.8%, respectively; P = 0.71), 5 years (65.6% versus 54.4%, respectively; P = 0.02), and 10 years (47.3% versus 44.2%, respectively; P = 0.55; log-rank P = 0.038). Although there was an overall significant difference, the survival curves almost reach each other after 10 years, which is most likely caused by other risk factors being less in DCD livers. Patient survival was not significantly different (P = 0.59). Multivariate Cox regression analysis showed a hazard ratio of 1.7 (P < 0.001) for DCD (corrected for ET-DRI and recipient factors). First warm ischemia time (WIT), which is the time from the end of circulation until aortic cold perfusion, over 25 minutes was associated with a lower graft survival in univariate analysis of all DCD transplants (P = 0.002). In conclusion, DCD LT has an increased risk for diminished graft survival compared to DBD. There was no significant difference in patient survival. DCD allografts with a first WIT > 25 minutes have an increased risk for a decrease in graft survival. Liver Transplantation 22 1107-1114 2016 AASLD. [less ▲]

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See detailLoss of oocytes due to conditional ablation of Murine double minute 2 (Mdm2) gene is p53-dependent and results in female sterility.
Livera, Gabriel; Uzbekov, Rustem; Jarrier, Peggy et al

in FEBS Letters (2016), 590(16), 2566-74

Murine double minute 2 and 4 (Mdm2, Mdm4) are major p53-negative regulators, preventing thus uncontrolled apoptosis induction in numerous cell types, although their function in the female germ line has ... [more ▼]

Murine double minute 2 and 4 (Mdm2, Mdm4) are major p53-negative regulators, preventing thus uncontrolled apoptosis induction in numerous cell types, although their function in the female germ line has received little attention. In the present work, we have generated mice with specific invalidation of Mdm2 and Mdm4 genes in the mouse oocyte (Mdm2(Ocko) and Mdm4(Ocko) mice), to test their implication in survival of these germ cells. Most of the Mdm2(Ocko) but not Mdm4(Ocko) mice were sterile, with a dramatic reduction of the weight of ovaries and genital tract, a strong increase in follicle-stimulating hormone and luteinizing hormone serum levels, and a reduction of anti-mullerian hormone serum levels. Histological analyses revealed an obvious decrease of the number of growing follicles beyond the primary stage in Mdm2(Ocko) ovaries in comparison to controls, with a pronounced increase in the apparition of primary atretic follicles, most being devoid of oocyte. Similar phenotypes were observed with Mdm2(Ocko) Mdm4(Ocko) ovaries, with no worsening of the phenotype. However, we failed to detect any increase in p53 level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4, has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype. [less ▲]

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See detailInterfascial spread of injectate after adductor canal injection in fresh human cadavers
GOFFIN, Pierre ULg; LECOQ, Jean-Pierre ULg; NINANE, Vincent ULg et al

in Anesthesia and Analgesia (2016), 123(2), 501-503

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See detailCFE Forum 2016: Rebuilding International Taxation – How To Square the Circle?
Richelle, Isabelle ULg; Gerzova, Larisa; Popa, Oana et al

in European Taxation (2016)

In this note, the authors provide a summary of the presentations made at the CFE Forum 2016 held in Brussels on 21 April 2016.

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See detailBovine leukemia virus becomes established in dairy herds before the first lactation
Merlini, Ramiro; Gutiérrez, Geronimo; Alvarez, Irene et al

in Archives of Virology (2016), 161

In this work, we studied seven groups of pregnant heifers from a consortium of dairy farms heavily infected with bovine leukemia virus (BLV). ELISA testing showed that the seroprevalence ranges of BLV in ... [more ▼]

In this work, we studied seven groups of pregnant heifers from a consortium of dairy farms heavily infected with bovine leukemia virus (BLV). ELISA testing showed that the seroprevalence ranges of BLV in heifers between 36.1 and 66.5 %. No significant differences in proviral load were found when comparing heifers with adult cattle. Before their first delivery, more than 9.8 % of heifers show a high proviral load. Because BLV infection can occur during the first two years of life, the rationale of any strategy should be to take action as early as possible after birth. [less ▲]

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See detailScaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).
Bousquet, J.; Farrell, J.; Crooks, G. et al

in Clinical and translational allergy (2016), 6

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic ... [more ▼]

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing. [less ▲]

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See detailFruit biomass availability along a forest cover gradiant
Pessoa; Rocca, Larissa; Talora, Daniela et al

in Biotropica (2016), doi:10.1111/btp.12359

Habitat loss is the main driver of the current high rate of species extinction, particularly in tropical forests. Understanding the factors associated with biodiversity loss, such as the extinction of ... [more ▼]

Habitat loss is the main driver of the current high rate of species extinction, particularly in tropical forests. Understanding the factors associated with biodiversity loss, such as the extinction of species interactions and ecological functions, is an urgent priority. Here, our aim was to evaluate how landscape-scale forest cover influences fruit biomass comparing different tree functional groups. We sampled 20 forest fragments located within landscapes with forest cover ranging from 2 to 93 percent in the Atlantic Forest of southern Bahia, Brazil. In each fragment, we established five plots of 25 × 4 m and carried out phenological observations on fleshy fruit throughout one year on all trees ≥ 5 cm dbh. We estimated fruit availability by direct counting all fruits and derived fruit biomass from this count. We used spatial mixed linear models to evaluate the effects of forest cover on species richness, abundance, and fruit biomass. Our results indicated that forest cover was the main explanatory variable and negatively influenced the total richness and abundance of zoochoric and shade-tolerant but not shade-intolerant species. A linear model best explained variations in richness and abundance of total and shade-tolerant species. We also found that forest cover was positively correlated with the fruit biomass produced by all species and by the shade-tolerant assemblages, with linear models best explaining both relationships. The loss of shade-tolerant species and the lower fruit production in fragments with lower landscape-scale forest cover may have implications for the maintenance of frugivore, seed dispersal service, and plant recruitment. [less ▲]

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See detailDEM modeling of ball mills with experimental validation: influence of contact parameters on charge motion and power draw
Boemer, Dominik ULg; Ponthot, Jean-Philippe ULg

in Computational Particle Mechanics (2016), 4(1), 53-67

Discrete element method simulations of a 1:5-scale laboratory ball mill are presented in this paper to study the influence of the contact parameters on the charge motion and the power draw. The position ... [more ▼]

Discrete element method simulations of a 1:5-scale laboratory ball mill are presented in this paper to study the influence of the contact parameters on the charge motion and the power draw. The position density limit is introduced as an efficient mathematical tool to describe and to compare the macroscopic charge motion in different scenarios, i.a. with different values of the contact parameters. While the charge motion and the power draw are relatively insensitive to the stiffness and the damping coefficient of the linear spring-slider-damper contact law, the coefficient of friction has a strong influence since it controls the sliding propensity of the charge. Based on the experimental calibration and validation by charge motion photographs and power draw measurements, the descriptive and predictive capabilities of the position density limit and the discrete element method are demonstrated, i.e. the real position of the charge is precisely delimited by the respective position density limit and the power draw can be predicted with an accuracy of about 5 %. [less ▲]

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See detailApports phénoménologiques à l’étude de la relation au corps dans le jeu vidéo
Delbouille, Julie ULg

in Implications philosophiques (2016)

J’évite un obstacle. Je cours. Je saute. Alors que quelques notes de musique m’avertissent de l’échec de ce dernier mouvement, je vois mon corps chuter, happé par le vide au-delà de l’écran. Cette scène ... [more ▼]

J’évite un obstacle. Je cours. Je saute. Alors que quelques notes de musique m’avertissent de l’échec de ce dernier mouvement, je vois mon corps chuter, happé par le vide au-delà de l’écran. Cette scène, qui tout comme ses multiples variations s’inscrit en filigrane au cœur de nombreuses expériences vidéoludiques, soulève la question du rapport au corps dans le jeu vidéo. Dans le champ des Game et des Play Studies, nombreux sont les chercheurs qui se sont déjà emparés de l’interactivité comme objet d’étude, et d’une de ses modalités dans le jeu vidéo : l’avatar. Interface récurrente entre le joueur et l’univers vidéoludique, nous postulons que cette « enveloppe pilotable » constitue une porte d’entrée pour envisager la problématique corporelle dans le jeu vidéo. En effet, la fonction d’incarnation permise par l’avatar ajoute à la relation entre le corps et l’esprit du joueur une dimension nouvelle : celle du corps virtuel. Ce corps « autre », dont le joueur prend possession, constitue une des conditions de son « insertion » dans le monde du jeu. [less ▲]

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See detailGd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting.
Plissonneau; Pansieri, Jonathan; Heinrich-Balard, L et al

in Journal of Nanobiotechnology (2016), 14(1), 10118612951-016-0212-

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See detailHCOOH distributions from IASI for 2008-2014: comparison with ground-based FTIR measurements and a global chemistry-transport model
Pommier, M.; Clerbaux, C.; Coheur, P.-F. et al

in Atmospheric Chemistry and Physics (2016), 16

Formic acid (HCOOH) is one of the most abundant volatile organic compounds in the atmosphere. It is a major contributor to rain acidity in remote areas. There are, however, large uncertainties on the ... [more ▼]

Formic acid (HCOOH) is one of the most abundant volatile organic compounds in the atmosphere. It is a major contributor to rain acidity in remote areas. There are, however, large uncertainties on the sources and sinks of HCOOH and therefore HCOOH is misrepresented by global chemistry-transport models. This work presents global distributions from 2008 to 2014 as derived from the measurements of the Infrared Atmospheric Sounding Interferometer (IASI), based on conversion factors between brightness temperature differences and representative retrieved total columns over seven regions: Northern Africa, southern Africa, Amazonia, Atlantic, Australia, Pacific, and Russia. The dependence of the measured HCOOH signal on the thermal contrast is taken into account in the conversion method. This conversion presents errors lower than 20 % for total columns ranging between 0.5 and 1 × 1016 molec/cm2 but reaches higher values, up to 78 %, for columns that are lower than 0.3 × 1016 molec/cm2. Signatures from biomass burning events are highlighted, such as in the Southern Hemisphere and in Russia, as well as biogenic emission sources, e.g., over the eastern USA. A comparison between 2008 and 2014 with ground-based Fourier transform infrared spectroscopy (FTIR) measurements obtained at four locations (Maido and Saint-Denis at La Réunion, Jungfraujoch, and Wollongong) is shown. Although IASI columns are found to correlate well with FTIR data, a large bias (> 100 %) is found over the two sites at La Réunion. A better agreement is found at Wollongong with a negligible bias. The comparison also highlights the difficulty of retrieving total columns from IASI measurements over mountainous regions such as Jungfraujoch. A comparison of the retrieved columns with the global chemistry-transport model IMAGESv2 is also presented, showing good representation of the seasonal and interannual cycles over America, Australia, Asia, and Siberia. A global model underestimation of the distribution and a misrepresentation of the seasonal cycle over India are also found. A small positive trend in the IASI columns is observed over Australia, Amazonia, and India over the 2008–2014 period (from 0.7 to 1.5 %/year), while a decrease of ∼ 0.8 %/year is measured over Siberia. [less ▲]

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See detailEpiphytic bryozoans on Neptune grass – a sample-based data set
Lepoint, Gilles ULg; Heughebaert, André; Michel, Loïc ULg

in ZooKeys (2016), 606

Background The seagrass Posidonia oceanica L. Delile, commonly known as Neptune grass, is an endemic species of the Mediterranean Sea. It hosts a distinctive and diverse epiphytic community, dominated by ... [more ▼]

Background The seagrass Posidonia oceanica L. Delile, commonly known as Neptune grass, is an endemic species of the Mediterranean Sea. It hosts a distinctive and diverse epiphytic community, dominated by various macroalgal and animal organisms. Mediterranean bryozoans have been extensively studied but quantitative data assessing temporal and spatial variability have rarely been documented. In Lepoint et al. (2014a, b) occurrence and abundance data of epiphytic bryozoan communities on leaves of P. oceanica inhabiting the Revellata Bay (Corsica, Mediterranean Sea) were reported and trophic ecology of Electra posidoniae Gautier assessed. New information Here, we provide metadata information on data set discussed in Lepoint et al. 2014a and published on the GBIF portal as a sampling-event data set: http://ipt.biodiversity.be/resource?r=ulg_bryozoa&v=1.0). The data set, compared to Lepoint et al. 2014a, is enriched by data concerning species settled on Posidonia scales (dead petiole of Posidonia leaves, remaining after limb abscission). [less ▲]

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See detailMomentum- and Heat-Flux Parameterization at Dome C, Antarctica: A Sensitivity Study
Vignon, Etienne; Genthon, Christophe; Barral, Hélène et al

in Boundary-Layer Meteorology (2016)

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See detailPolarization Measurements of Hot Dust Stars and the Local Interstellar Medium
Marshall, J. P.; Cotton, D. V.; Bott, K. et al

in Astrophysical Journal (2016), 825

Debris discs are typically revealed through the presence of excess emission at infrared wavelengths. Most discs exhibit excess at mid- and far-infrared wavelengths, analogous to the solar system’s ... [more ▼]

Debris discs are typically revealed through the presence of excess emission at infrared wavelengths. Most discs exhibit excess at mid- and far-infrared wavelengths, analogous to the solar system’s Asteroid and Edgeworth-Kuiper belts. Recently, stars with strong (˜1%) excess at near-infrared wavelengths were identified through interferometric measurements. Using the HIgh Precision Polarimetric Instrument, we examined a sub-sample of these hot dust stars (and appropriate controls) at parts-per-million sensitivity in SDSS g‧ (green) and r‧ (red) filters for evidence of scattered light. No detection of strongly polarized emission from the hot dust stars is seen. We, therefore, rule out scattered light from a normal debris disk as the origin of this emission. A wavelength-dependent contribution from multiple dust components for hot dust stars is inferred from the dispersion (the difference in polarization angle in red and green) of southern stars. Contributions of 17 ppm (green) and 30 ppm (red) are calculated, with strict 3-σ upper limits of 76 and 68 ppm, respectively. This suggests weak hot dust excesses consistent with thermal emission, although we cannot rule out contrived scenarios, e.g., dust in a spherical shell or face-on discs. We also report on the nature of the local interstellar medium (ISM), obtained as a byproduct of the control measurements. Highlights include the first measurements of the polarimetric color of the local ISM and the discovery of a southern sky region with a polarization per distance thrice the previous maximum. The data suggest that λ [SUB]max[/SUB], the wavelength of maximum polarization, is bluer than typical. [less ▲]

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Cartilage (2016)

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no ... [more ▼]

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA. [less ▲]

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See detailLa biodiversité entomologique comme source d’aliments à Kinshasa (République démocratique du Congo)
Nsevolo, Papy; Alabi, Taofic ULg; Caparros Megido, Rudy ULg et al

in Annales de la Société Entomologique de France (2016)

L’exploitation des produits forestiers non ligneux dont notamment les insectes comestibles jouent un rôle important dans les habitudes alimentaires et économies locales des populations autochtones du ... [more ▼]

L’exploitation des produits forestiers non ligneux dont notamment les insectes comestibles jouent un rôle important dans les habitudes alimentaires et économies locales des populations autochtones du bassin du Congo. Bien que la consommation d’insectes en République Démocratique du Congo soit une pratique ancienne, l’inventaire et l’identification taxonomique des espèces consommées ainsi que la caractérisation de la filière « entomophagie » sont encore mal maitrisés. Toutefois, nos études axées sur la ville de Kinshasa ont permis d’inventorier 14 espèces comestibles régulièrement consommées. Elles appartiennent à l’ordre des Lépidoptères (46,7%), des Isoptères (18,6%), des Orthoptères (17,6%), des Coléoptères (9,7%) et des Hyménoptères (3,7%). De façon générale, 80% de la population de Kinshasa consomment au minimum une espèce d’insecte 5 jours par mois avec des quantités variant de 66,4 à 154 g d’insectes par personne par jour en fonction des différents ordres. Les acteurs de la filière sont majoritairement des femmes. Les revenus générés par l’activité concourent au bien-être des ménages, à la réduction de la pauvreté et de l’insécurité alimentaire dans de la capitale Kinshasa. [less ▲]

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See detailHabenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade
Halluin, Caroline; Madelaine, Romain; Naye, Francois et al

in PLoS ONE (2016), 11(7), 0158210

The habenulae are highly conserved nuclei in the dorsal diencephalon that connect the forebrain to the midbrain and hindbrain. These nuclei have been implicated in a broad variety of behaviours in humans ... [more ▼]

The habenulae are highly conserved nuclei in the dorsal diencephalon that connect the forebrain to the midbrain and hindbrain. These nuclei have been implicated in a broad variety of behaviours in humans, primates, rodents and zebrafish. Despite this, the molecular mechanisms that control the genesis and differentiation of neural progenitors in the habenulae remain relatively unknown. We have previously shown that, in zebrafish, the timing of habenular neurogenesis is left-right asymmetric and that in the absence of Nodal signalling this asymmetry is lost. Here, we show that habenular neurogenesis requires the homeobox transcription factor Pax6a and the redundant action of two proneural bHLH factors, Neurog1 and Neurod4. We present evidence that Hedgehog signalling is required for the expression of pax6a, which is in turn necessary for the expression of neurog1 and neurod4. Finally, we demonstrate by pharmacological inhibition that Hedgehog signalling is required continuously during habenular neurogenesis and by cell transplantation experiments that pathway activation is required cell autonomously. Our data sheds light on the mechanism underlying habenular development that may provide insights into how Nodal signalling imposes asymmetry on the timing of habenular neurogenesis. [less ▲]

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See detailAzacytidine mitigates experimental sclerodermic chronic graft-versus-host disease
Fransolet, Gilles ULg; Ehx, Grégory ULg; SOMJA, Joan ULg et al

in Journal of Hematology & Oncology (2016), 9

Background <br />Previous studies have demonstrated that regulatory T cells (Tregs) play a protective role in the pathogenesis of chronic graft-versus-host disease (cGVHD). Tregs constitutively express ... [more ▼]

Background <br />Previous studies have demonstrated that regulatory T cells (Tregs) play a protective role in the pathogenesis of chronic graft-versus-host disease (cGVHD). Tregs constitutively express the gene of the transcription factor Foxp3 whose CNS2 region is heavily methylated in conventional CD4+ T cells (CD4+Tconvs) but demethylated in Tregs. <br />Methods <br />Here, we assessed the impact of azacytidine (AZA) on cGVHD in a well-established murine model of sclerodermic cGVHD (B10.D2 (H-2d) → BALB/cJ (H-2d)). <br />Results <br />The administration of AZA every 48 h from day +10 to day +30 at the dose of 0.5 mg/kg or 2 mg/kg mitigated chronic GVHD. Further, AZA-treated mice exhibited higher blood and thymic Treg frequencies on day +35, as well as higher demethylation levels of the Foxp3 enhancer and the IL-2 promoter in splenocytes at day +52. Interestingly, Tregs from AZA-treated mice expressed more frequently the activation marker CD103 on day +52. AZA-treated mice had also lower counts of CD4+Tconvs and CD8+ T cells from day +21 to day +35 after transplantation, as well as a lower proportion of CD4+Tconvs expressing the Ki67 antigen on day +21 demonstrating an anti-proliferating effect of the drug on T cells. <br />Conclusions <br />Our results indicate that AZA prevented sclerodermic cGVHD in a well-established murine model of cGVHD. These data might serve as the basis for a pilot study of AZA administration for cGVHD prevention in patients at high risk for cGVHD. [less ▲]

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See detailDémographie et performances zootechniques des élevages bovins traditionnels au Nord Bénin
Chabi Toko, Roukayath ULg; Adégbidi, Anselme; Lebailly, Philippe ULg

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (2016), 69(1), 33-39

The study was conducted with 150 Fulani herders in the departments of Borgu and Alibori in Benin. It aimed to determine the zootechnical parameters of traditional cattle farms. The survey collected ... [more ▼]

The study was conducted with 150 Fulani herders in the departments of Borgu and Alibori in Benin. It aimed to determine the zootechnical parameters of traditional cattle farms. The survey collected information on the characteristics of cattle herds. The results showed a high proportion of females (76%), an average herd size (66 animals) and the prevalence of the Borgu breed (86%). The herds also showed a low breeding performance, characterized by a high calf mortality rate (10%), and low reproductive parameters (64% calving and fertility rates). In a year, 0.57 calf was weaned on average by its dam. The low performance of cattle farms in coastal countries such as Benin is consistent with that of pastoral areas, which is complementary in terms of meat supply to West African markets. [less ▲]

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See detailAsymptotic properties of free monoid morphisms
Charlier, Emilie ULg; Leroy, Julien ULg; Rigo, Michel ULg

in Linear Algebra & its Applications (2016), 500

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See detailProbing TRAPPIST-1-like Systems with K2
Demory, Brice-Olivier; Queloz, Didier; Alibert, Yann et al

in Astrophysical Journal Letters (2016), 825

The search for small planets orbiting late M dwarfs holds the promise of detecting Earth-size planets for which their atmospheres could be characterized within the next decade. The recent discovery of ... [more ▼]

The search for small planets orbiting late M dwarfs holds the promise of detecting Earth-size planets for which their atmospheres could be characterized within the next decade. The recent discovery of TRAPPIST-1 entertains hope that these systems are common around hosts located at the bottom of the main sequence. In this Letter, we investigate the ability of the repurposed Kepler mission (K2) to probe planetary systems similar to TRAPPIST-1. We perform a consistent data analysis of 189 spectroscopically confirmed M5.5 to M9 late M dwarfs from Campaigns 1-6 to search for planet candidates and inject transit signals with properties matching TRAPPIST-1b and c. We find no transiting planet candidates across our K2 sample. Our injection tests show that K2 is able to recover both TRAPPIST-1 planets for 10% of the sample only, mainly because of the inefficient throughput at red wavelengths resulting in Poisson-limited performance for these targets. Increasing injected planetary radii to match GJ 1214b’s size yields a recovery rate of 70%. The strength of K2 is its ability to probe a large number of cool hosts across the different campaigns, out of which the recovery rate of 10% may turn into bona fide detections of TRAPPIST-1-like systems within the next two years. [less ▲]

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See detailIgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship with inflammatory phenotypes and disease severity.
Manise, Maïté ULg; Bakayoko, B.; SCHLEICH, FLorence ULg et al

in International Journal of Clinical Practice (2016), 70(7), 596-605

BACKGROUND: Atopy is known to play an important role in the asthmatic disease. The main objective of this study was to evaluate the frequency of sensitisation to common aeroallergens in a cohort of ... [more ▼]

BACKGROUND: Atopy is known to play an important role in the asthmatic disease. The main objective of this study was to evaluate the frequency of sensitisation to common aeroallergens in a cohort of asthmatics with different inflammatory phenotypes and disease severity. METHODS: We have conducted a retrospective cross-sectional study including 772 asthmatics recruited between 2003 and 2014 in our Asthma Clinic. The patients were defined as asthmatics on the basis of respiratory symptoms together with a positive methacholine test (PC20M) < 16 mg/ml and/or a reversibility to short-acting beta2-agonists (salbutamol) >/= 12% and 200 ml. Sensitisation to house dust mites, grass and birch pollens, cats, dogs and moulds was assessed by RAST and a specific immunoglobulin E (IgE) > 0.35 kU/l was considered as significant. Inflammatory phenotypes were subdivided between pauci-granulocytic (n = 309) (40%), eosinophilic (n = 311) (40%), neutrophilic (N = 134) (17%) and mixed-granulocytic (N = 18) (3%) asthmatics. Severe asthmatics (n = 118) were defined according to the American Thoracic Society (ATS 2000) criteria and compared with mild-to-moderate asthmatics (N = 654). RESULTS: The eosinophilic phenotype was associated with higher levels of total serum IgE compared with neutrophilic and pauci-granulocytic asthma (p < 0.001 for both). Sensitisation rate to dogs and cats was higher in eosinophilic asthmatics (31% and 37%, respectively, p < 0.01 both) compared with neutrophilic (18% and 23% respectively) and pauci-granulocytic asthmatics (20% and 24%, respectively), while sensitisation rate to house dust mites and moulds were rather similar between the groups (ranging from 33% to 40% and from 10% to 16%, respectively). Severe asthmatics had slightly increased total serum IgE compared with mild-to-moderate asthmatics (p < 0.05) without any difference in the sensitisation rate to common aeroallergens. CONCLUSION: Eosinophilic asthma exhibits higher total serum IgE and sensitisation rate towards animal dander while clinical severity, though also associated with higher total IgE, did not preferentially relate to any type of common aeroallergens. [less ▲]

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See detailTherapy with proton-pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD.
Baumeler, Luzia; Papakonstantinou, Eleni; Milenkovic, Branislava et al

in Respirology (Carlton, Vic.) (2016), 21(5), 883-90

BACKGROUND AND OBJECTIVE: Gastroesophageal reflux disease (GERD) symptoms are associated with a higher risk of chronic obstructive pulmonary disease (COPD) exacerbation. We hypothesize that treatment with ... [more ▼]

BACKGROUND AND OBJECTIVE: Gastroesophageal reflux disease (GERD) symptoms are associated with a higher risk of chronic obstructive pulmonary disease (COPD) exacerbation. We hypothesize that treatment with proton pump inhibitors reduces the risk of exacerbation in patients with stable COPD. METHODS: A total of 638 patients with stable COPD for >/=6 weeks, >/=10 pack-years of smoking and Global Initiative for Chronic Obstructive Lung Disease II-IV seeking care in tertiary hospitals in eight European countries in the Predicting Outcome using Systemic Markers in Severe Exacerbations-COPD cohort was prospectively evaluated by us. Comorbidities including associated medical treatment were assessed at baseline, at exacerbation and at biannual visits. Median observation time was 24 months. The primary study outcomes were exacerbation and/or death. RESULTS: A total of 85 (13.3%) of COPD patients were on anti-GERD therapy. These patients had higher annual and higher severe exacerbation rates (P = 0.009 and P = 0.002), decreased quality of life (SF-36: activity score P = 0.004, St. George's Respiratory Questionnaire: physical functioning P = 0.013 and social functioning P = 0.007), higher body mass airflow obstruction, dyspnea and exercise capacity index (P = 0.033) and Modified Medical Research Council scores (P = 0.002), shorter 6-min walking distance (P = 0.0004) and a higher adjusted Charlson score (P < 0.0001). Anti-GERD therapy was associated with a shorter time to severe exacerbation (HR 2.05 95% CI 1.37-3.08). Using three multivariable Cox-regression models, this association was independent of the following: (i) adjusted Charlson score and FEV1% predicted (HR 1.91 95% CI 1.26-2.90); (ii) adjusted Charlson score, body mass, airflow obstruction, dyspnea and exercise capacity index and Modified Medical Research Council (HR 1.62 95% CI 1.04-2.54); and (iii) adjusted Charlson score, FEV1% predicted and nine classes of medication for comorbidities (HR 1.63 95% CI 1.04-2.53). CONCLUSION: These findings suggest that patients with stable COPD receiving acid-suppressive therapy with proton pump inhibitors remain at high risk of frequent and severe exacerbations. [less ▲]

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See detailThe different origins of high- and low-ionization broad emission lines revealed by gravitational microlensing in the Einstein cross
Braibant, Lorraine ULg; Hutsemekers, Damien ULg; Sluse, Dominique ULg et al

in Astronomy and Astrophysics (2016), 592

We investigate the kinematics and ionization structure of the broad emission line region of the gravitationally lensed quasar QSO2237+0305 (the Einstein cross) using differential microlensing in the high ... [more ▼]

We investigate the kinematics and ionization structure of the broad emission line region of the gravitationally lensed quasar QSO2237+0305 (the Einstein cross) using differential microlensing in the high- and low-ionization broad emission lines. We combine visible and near-infrared spectra of the four images of the lensed quasar and detect a large-amplitude microlensing effect distorting the high-ionization CIV and low-ionization Hα line profiles in image A. While microlensing only magnifies the red wing of the Balmer line, it symmetrically magnifies the wings of the CIV emission line. Given that the same microlensing pattern magnifies both the high- and low-ionization broad emission line regions, these dissimilar distortions of the line profiles suggest that the high- and low-ionization regions are governed by different kinematics. Since this quasar is likely viewed at intermediate inclination, we argue that the differential magnification of the blue and red wings of Hα favors a flattened, virialized, low-ionization region whereas the symmetric microlensing effect measured in CIV can be reproduced by an emission line formed in a polar wind, without the need of fine-tuned caustic configurations. [less ▲]

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See detailMagnesium-doped cuprous oxide (Mg:Cu2O) thin films as a transparent p-type semiconductor
Avelas Resende, João ULg; Jimenez, Carmen; Nguyen, Ngoc Duy ULg et al

in Physica Status Solidi A. Applications and Materials Science (2016), 213(9), 22962302

The lack of a successful p-type transparent semiconductor delays the future implementation of transparent electron- ics. In the group semiconducting compounds, cuprous oxide (Cu2O) presents promising ... [more ▼]

The lack of a successful p-type transparent semiconductor delays the future implementation of transparent electron- ics. In the group semiconducting compounds, cuprous oxide (Cu2O) presents promising electrical and manufacturing features that establish it as a suitable candidate for p-type transparent semiconductors. However, high absorbance in the visible range reduces its application practical devices. In this work, we achieved the incorporation of magnesium in cuprous oxide grown by aerosol-assisted metal-organic chemical vapour deposition. The fabricated doped thin films reached up to 17% of magnesium, resulting in morphology changes. Electrical resistivity was reduced down to values as low as 6.6 Vcm, due to the increase of charge-carrier density. The optical transparency was enhanced compared to intrinsic cuprous oxide. [less ▲]

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See detailInsight into biting diversity to capture benthic prey in damselfishes (Pomacentridae)
Olivier, Damien ULg; Parmentier, Eric ULg; Frederich, Bruno ULg

in Zoologischer Anzeiger (2016), 264

The cerato-mandibular (c-md) ligament, joining the hyoid bar to the coronoid process of the angular, allows Pomacentridae to slam their mouth shut in a few milliseconds. Previous works have revealed that ... [more ▼]

The cerato-mandibular (c-md) ligament, joining the hyoid bar to the coronoid process of the angular, allows Pomacentridae to slam their mouth shut in a few milliseconds. Previous works have revealed that such a mechanism is used to feed, but some variability in biting patterns has been observed between two damselfish species. The pelagic feeder Amphiprion clarkii performs two different kinematic patterns to bite fixed prey, one that does not depend on the c-md ligament (biting-1) and one that does (biting-2). The benthic feeder Stegastes rectifraenum only performs biting-2. The present study aims to shed light on the occurrence of biting-2 in the feeding behaviour of Pomacentridae. To test our hypothesis that biting-2 would be the only biting pattern for benthic feeders, we compared biting behaviours among four species: one pelagic feeder, A. clarkii, and three benthic feeders, Neoglyphidodon nigroris, Stegastes leucostictus and S. rectifraenum. Our results showed that the four species were able to perform biting-2, but they do not support that the use of this pattern is related to trophic habits. Contrary to S. rectifraenum, the two other benthic feeders randomly used biting-1 and biting-2 patterns, similar to A. clarkii. Two hypotheses are discussed for explaining this variability within Pomacentridae. Finally, it has been recently shown that some damselfishes do not possess the c-md ligament. We therefore included two species lacking the c-md ligament (Chromis chromis and Abudefduf troschelii) in our study and we demonstrate our expectation that they are unable to perform biting-2. [less ▲]

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See detailLes puissances émergentes dans la bataille mondiale de l'attraction: Bollywood, vecteur du soft power de l'Inde?
Vlassis, Antonios ULg

in Interventions Economiques = Papers in Political Economy (2016), 55(July),

This article deals with the importance of the Indian film industry for the strengthening of India’s soft power and with the capability of the country to build an international status of active cultural ... [more ▼]

This article deals with the importance of the Indian film industry for the strengthening of India’s soft power and with the capability of the country to build an international status of active cultural power. As such, on the one hand, I seek to analyze the institutional features of the Indian movie system and to focus on the role of India within the international regime for audiovisual sector, and on the other hand, I aim to emphasize the worldwide cultural competition that India faces. The findings will show that the domestic structures are a major factor in order to understand the influence of India and its status within the world audiovisual economy, within which Hollywood has highly financing abilities and global distribution strategies. [less ▲]

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (2016), 6

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See detailA simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a Hot-Melt Extrusion process
Netchacovitch, Lauranne ULg; Thiry, Justine ULg; De Bleye, Charlotte ULg et al

in Talanta (2016), 154

When developing a new formulation, the development, calibration and validation steps of analytical methods based on vibrational spectroscopy are time-consuming. For each new formulation, real samples must ... [more ▼]

When developing a new formulation, the development, calibration and validation steps of analytical methods based on vibrational spectroscopy are time-consuming. For each new formulation, real samples must be produced and a “reference method” must be used in order to determine the Active Pharmaceutical Ingredient (API) content of each sample. To circumvent this issue, the paper presents a simple approach based on the film-casting technique used as a calibration tool in the framework of hot-melt extrusion process. Confocal Raman microscopic method was successfully validated for the determination of itraconazole content in film-casting samples. Then, hot-melt extrusion was carried out to produce real samples in order to confront the results obtained with confocal Raman microscopy and Ultra High Performance Liquid Chromatography (UHPLC). The agreement between both methods was demonstrated using a comparison study based on the Bland and Altman’s plot. [less ▲]

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See detailRadiative accidental matter
Da Silva Simoes, Catarina ULg; Aristizabal Sierra, Diego ULg; Wegman Ostrosky, Daniel ULg

in Journal of High Energy Physics [=JHEP] (2016)

Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number ... [more ▼]

Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, bigbang nucleosynthesis and electroweak perturbativity, fi nding that the latter places the most stringent constraints on the mass spectra. These results allow the identi fication of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that mu -> e gamma has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below 5 105 GeV, a value (naturally) assured by the radiative suppression mechanism. Sizeable tau -> mu gamma branching fractions within SuperKEKB sensitivity are possible for lower lepton-number breaking scales. We thus point out that these scenarios can be tested not only in direct searches but also in lepton flavor-violating experiments. [less ▲]

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See detailInterpreting the Infinitesimal Mathematics of Leibniz and Euler
Bair, Jacques ULg; Blaszczyk, Piotr; Ely, Robert et al

in Journal for General Philosophy of Science (2016)

We apply Benacerraf’s distinction between mathematical ontology and mathematical practice (or the structures mathematicians use in practice) to examine contrasting interpretations of infinitesimal ... [more ▼]

We apply Benacerraf’s distinction between mathematical ontology and mathematical practice (or the structures mathematicians use in practice) to examine contrasting interpretations of infinitesimal mathematics of the seventeenth and eighteenth century, in the work of Bos, Ferraro, Laugwitz, and others. We detect Weierstrass’s ghost behind some of the received historiography on Euler’s infinitesimal mathematics, as when Ferraro proposes to understand Euler in terms of a Weierstrassian notion of limit and Fraser declares classical analysis to be a “primary point of reference for understanding the eighteenth-century theories.” Meanwhile, scholars like Bos and Laugwitz seek to explore Eulerian methodology, practice, and procedures in a way more faithful to Euler’s own. Euler’s use of infinite integers and the associated infinite products are analyzed in the context of his infinite product decomposition for the sine function. Euler’s principle of cancellation is compared to the Leibnizian transcendental law of homogeneity. The Leibnizian law of continuity similarly finds echoes in Euler. We argue that Ferraro’s assumption that Euler worked with a classical notion of quantity is symptomatic of a post-Weierstrassian placement of Euler in the Archimedean track for the development of analysis, as well as a blurring of the distinction between the dual tracks noted by Bos. Interpreting Euler in an Archimedean conceptual framework obscures important aspects of Euler’s work. Such a framework is profitably replaced by a syntactically more versatile modern infinitesimal framework that provides better proxies for his inferential moves. [less ▲]

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See detailMotiver sans contraindre, séduire sans manipuler
Defays, Jean-Marc ULg

in Le Langage et l'Homme (2016), 2016-1

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See detailSafe, flexible and efficient sheet metal forming: formability - fracture, incremental sheet forming & rolling
Banabic, Dorel; Habraken, Anne ULg; Yoon, Jeong Whan

in International Journal of Material Forming (2016), 9(3),

Editorial of the thematic issue

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See detailTrophic interactions between two neustonic organisms: insights from Bayesian stable isotope data analysis tools
Lepoint, Gilles ULg; Laurent, Bernard; Gobert, Sylvie ULg et al

in Belgian Journal of Zoology (2016), 146(2), 123-133

The by-the-wind sailor Velella velella (Linnaeus, 1758) and its predator, the violet snail Janthina globosa (Swainson, 1822) are both floating neustonic organisms. Despite their global oceanic ... [more ▼]

The by-the-wind sailor Velella velella (Linnaeus, 1758) and its predator, the violet snail Janthina globosa (Swainson, 1822) are both floating neustonic organisms. Despite their global oceanic distribution and widespread blooms of V. velella in recent years, many gaps remain in our understanding about prey/predator interactions between these two taxa. Using stable isotope ratios of carbon and nitrogen, we aimed to study the trophic relationship between V. velella and J. globosa and investigate diet variation of V. velella and J. globosa in relation to individuals’ size. Bayesian approaches were used to calculate isotopic niche metrics and the contribution of V. velella to the J. globosa diet. Our data showed that the isotopic niche of V. velella differed markedly from that of J. globosa. It was larger and did not overlap that of the J. globosa, indicating a more variable diet but at a lower trophic level than J. globosa. The isotopic niche of V. velella also varied according to the size class of the individual. Small individuals showed a larger isotopic niche than larger animals and low overlap with those of the larger individuals. J. globosa displayed very low isotopic variability and very small isotopic niches. In contrast, there were no isotopic composition nor isotopic niche differences between J. globosa of any size. This very low isotopic variability suggested that J. globosa is a specialist predator, feeding, at least in this aggregation, principally on V. velella. Moreover, outputs of a stable isotope mixing model revealed preferential feeding on medium to large (> 500 mm2) V. velella colonies. While our isotopic data showed the trophic relationship between V. velella and J. globosa, many questions remain about the ecology of these two organisms, demonstrating the need for more fundamental studies about neustonic ecosystems. [less ▲]

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See detailReprésentations du français et motivations des allophones à l'apprendre et à l'enseigner
Defays, Jean-Marc ULg; Geron, Geneviève

in Le Langage et l'Homme (2016)

Dans les circonstances actuelles de la mondialisation et de ses implications en matière de pratique et d’enseignement des langues, comme en matière de relations et d’interactions multiculturelles, le ... [more ▼]

Dans les circonstances actuelles de la mondialisation et de ses implications en matière de pratique et d’enseignement des langues, comme en matière de relations et d’interactions multiculturelles, le français – concurrencé dans sa diffusion et dans ses usages – doit revoir et renforcer sa position sur le marché des langues comme dans les imaginaires des personnes susceptibles de l’apprendre ou de l’enseigner. On peut compter de multiples raisons, des plus passionnelles au plus rationnelles, pour apprendre/ enseigner telle ou telle langue…ou au contraire pour en choisir une autre. Les représentations associées à la langue et à la culture françaises ont été très diverses, voire paradoxales, au cours de l’histoire : certaines les ont beaucoup servies, d’autres les handicapent toujours, de nouvelles émergent. La question de savoir « pourquoi » un étranger décide d’apprendre ou d’enseigner le français renvoie évidemment à celle de savoir « pour quoi », en deux mots : le but qu’il vise et la motivation qui l’anime au début et au cours de son projet. À l’aide de témoignages relatifs à différents contextes et publics d’enseignement, nous souhaiterions dresser un état des lieux des représentations et des motivations que les apprenants, les enseignants, les autorités éducatives étrangers invoquent actuellement en faveur ou défaveur du français. Et de nous demander comment il est possible – au sein de ces différents contextes – de les analyser, de les améliorer, de les didactiser dans le cadre d’un enseignement plurilingue et interculturel, et quels rôles les enseignants peuvent jouer, quels outils ils ont à leur disposition, quelle préparation ils devraient recevoir à ce propos. [less ▲]

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See detailBoosting shape classifiers accuracy by considering the inverse shape
Pierard, Sébastien ULg; Lejeune, Antoine ULg; Van Droogenbroeck, Marc ULg

in Journal of Pattern Recognition Research (2016), 11(1), 41-54

Many techniques exist for describing shapes. These techniques almost exclusively consider the contour or the inside of the shape; the major problem for describing the outside of a shape, or inverse shape ... [more ▼]

Many techniques exist for describing shapes. These techniques almost exclusively consider the contour or the inside of the shape; the major problem for describing the outside of a shape, or inverse shape, being that it has an infinite extension. In this paper, we show how to adapt two shape descriptors, one region based, the Cover By Rectangles, and one transform based, the Zernike moments, to be applicable to the inverse shape. We analyze their properties, and show how to deal with the infinite extension of the inverse shape. Then, we apply these descriptors to shape classification and compare representations that use the shape, its inverse, or both. Our experiments establish that, for shape classification, a representation integrating the inverse shape often outperforms a representation restricted to the shape. This opens the path for better techniques that could use, as a rule of thumb, both the representations of a shape and its inverse for the purpose of classification. [less ▲]

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See detailTemporal habitat shift of a polymorphic newt species under predation risk
Winandy, Laurane ULg; Colin, Mélanie; Denoël, Mathieu ULg

in Behavioral Ecology (2016), 27(4), 1025-1032

The temporal partitioning hypothesis suggests that the evolution of different diel activity rhythms in animals might facilitate the coexistence between prey and predators. However, the temporal shift of ... [more ▼]

The temporal partitioning hypothesis suggests that the evolution of different diel activity rhythms in animals might facilitate the coexistence between prey and predators. However, the temporal shift of habitat use induced by predation has rarely been observed. The study of such a mechanism is particularly relevant for introduced species because it might explain how native species can persist or decline in response to the presence of alien species. The introduction of fish into ponds inhabited by amphibians has severe consequences for their occurrence and abundance. Fish particularly affect an alternative newt phenotype, the paedomorph, which does not undergo metamorphosis and maintains larval traits such as gills at the adult stage. In a laboratory design, we assessed the diel patterns of habitat use in the 2 distinct morphological phenotypes of palmate newt (Lissotriton helveticus) in the presence or absence of goldfish (Carassius auratus). Both newt phenotypes avoided a risky habitat more in the presence than in the absence of fish. This habitat shift was more pronounced during the daytime (i.e., when the risk could be considered higher for the newts) than during nighttime. However, in contrast to metamorphs, paedomorphs showed less adaptive changes according to temporal risk and remained in their shelter for most of the time. Temporal and habitat partitioning at the diel scale between native and alien species might promote their coexistence, but diel change can also imply a cost in the overall reduction of the time allocated to essential activities, showing that species interactions remain complex. [less ▲]

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See detailPlant mitochondrial complex I composition and assembly: a review
Subrahmanian, Nitya; Remacle, Claire ULg; Hamel, Patrice

in Biochimica et Biophysica Acta-Bioenergetics (2016), 1857(7), 1001-1014

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See detailPerformance et Innovation en PME: une relation à questionner
Ajzen, Michel; Rondeaux, Giseline ULg; Pichault, François ULg et al

in Revue Internationale P.M.E. (2016), 29(2), 65-94

Noting that in management science, management policies would have all, the ultimate ambition of contributing to company performance and the innovative capacity of a company would be a sine qua non of this ... [more ▼]

Noting that in management science, management policies would have all, the ultimate ambition of contributing to company performance and the innovative capacity of a company would be a sine qua non of this performance, this article shows that (if) these two concepts refer to disparate content; (ii) the performance is primarily measured by distanced indicators (financial); (iii) the nature of the interdependence between innovation and performance is not unequivocal. Considering the weight of contextual variables, we show the interest to adopt a broader vision of concepts of innovation and performance in SMEs, capitalizing on the diversity of performance and innovation characterizations, and adopting an agnostic approach establishing no a priori link between them. This article proposes to broaden the concepts of innovation and performance by mobilizing indicators specific to SMEs and outlines a methodology to measure and weigh them as well as to provide researchers with tools to better understand the interactions between these variables. In doing so, we contribute to a critical approach of de-naturalization to emancipate SMEs and, more broadly, public and regulatory authorities, from narrow performative standards. [less ▲]

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See detailCognitive processes across anxiety disorders related to intolerance of uncertainty: Clinical Review
Vander Haegen, Marie ULg; Etienne, Anne-Marie ULg

in Cogent Psychology (2016), 3

Abstract: Objective: Being a relatively recent concept, the intolerance of uncertainty (IU) suffers from inconsistent definitions and conceptual overlap. The core objective of the study is to clarify its ... [more ▼]

Abstract: Objective: Being a relatively recent concept, the intolerance of uncertainty (IU) suffers from inconsistent definitions and conceptual overlap. The core objective of the study is to clarify its clinical manifestations and its involved cognitive processes. Method: The procedure is based on algorithms (equations of keywords) encoded simultaneously in databases (Scopus, PubMed, and PsycArticles). Results are filtered by the year (range of 10 years [2005–2015] because it is a recent concept) and the relevance of abstracts. Once the studies are appraised, results are categorized in two groups: studies which examine the IU in a clinical perspective (relations with one or several anxiety disorders) (cluster A) and those which measure the IU through a cognitive perspective (cognition, metacognition) (cluster B). Results: 66 results are retrieved: 50 results concern the cluster A and 16 examine the cluster B. The state of the IU varies between studies (e.g. predictor and mediator), which make comparisons difficult. Notwithstanding, the IU construct seems to be a broad transdiagnostic maintaining risk factor involved in a range of psychological disorders. Conclusion: This clustering supported that researchers and clinicians may benefit from incorporating IU within cognitive and computational research design and as a specific treatment target. [less ▲]

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See detailTopology optimization for minimum weight with compliance and simpli ed nominal stress constraints for fatigue resistance
Collet, Maxime ULg; Bruggi, Matteo; Duysinx, Pierre ULg

in Structural and Multidisciplinary Optimization (2016)

This work investigates a simpli ed approach to cope with the optimization of preliminary design of structures under local fatigue constraints along with a global enforcement on the overall compliance. The ... [more ▼]

This work investigates a simpli ed approach to cope with the optimization of preliminary design of structures under local fatigue constraints along with a global enforcement on the overall compliance. The problem aims at the minimization of the weight of linear elastic structures under given loads and boundary conditions. The expected sti ness of the optimal structure is provided by the global constraint, whereas a set of local stress-based constraints ask for a structure to be fatigue resistant. A modi ed Goodman fatigue strength comparison is implemented through the same formalism to address pressure-dépendent failure in materials as in Drucker-Prager strength criterion. As a simplification, the Sines approach is used to de ne the equivalent mean and alternating stresses to address the fatigue resistance for an infinite life time. Sines computation is based on the equivalent mean and alternate stress depending on the invariants of the stress tensor and itsdeviatoric part, respectively. The so-called singularity phenomenon is overcome by the implementation of a suitable qp-relaxation of the equivalent stress measures. Numerical examples are presented to illustrate the features of the achieved optimal layouts and of the proposed algorithm. [less ▲]

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See detailCapillary electrophoresis method to determine siRNA complexation with cationic liposomes
Furst, Tania ULg; Bettonville, Virginie ULg; Farcas, Elena ULg et al

in Electrophoresis (2016)

Small interfering RNA (siRNA) inducing gene silencing has great potential to treat many human diseases. To ensure effective siRNA delivery, it must be complexed with an appropriate vector, generally ... [more ▼]

Small interfering RNA (siRNA) inducing gene silencing has great potential to treat many human diseases. To ensure effective siRNA delivery, it must be complexed with an appropriate vector, generally nanoparticles. The nanoparticulate complex requires an optimal physiochemical characterization and the complexation efficiency has to be precisely determined. The methods usually used to measure complexation are gel electrophoresis and RiboGreen® fluorescence-based assay. However, those approaches are not automated and present some drawbacks such as the low throughput and the use of carcinogenic reagents. The aim of this work is to develop a new simple and fast method to accurately quantify the complexation efficiency. In this research, capillary electrophoresis (CE) was used to determine the siRNA complexation with cationic liposomes. The short-end injection mode applied enabled siRNA detection in less than 5 min. Moreover, the CE technique offers many advantages compared to the other classical methods. It is automated, does not require sample preparation and expensive reagents. Moreover, no mutagenic risk is associated to CE approach since no carcinogenic product is used. Finally, this methodology can also be extended to the characterization of other types of nanoparticles encapsulating siRNA, such as cationic polymeric nanoparticles. [less ▲]

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See detailSoyons optimistes
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59(4), 3

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See detailEntretien avec Michel Dumoulin. Regards sur les mondes de la recherche et de l'histoire.
Genin, Vincent ULg

in Contemporanea (2016), XXXVIII(2),

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See detailQuand Caïn scrute Abel. Reflets mutuels des neutralités belge et suisse autour de la Première Guerre mondiale
Genin, Vincent ULg

in Revue Générale (2016), 2016/4(juillet-août),

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See detailLe sexe ratio chez les bovins : mécanismes potentiels.
Hanzen, Christian ULg; Chastant-Maillard, Sylvie; Rao, Anne-Sophie ULg et al

in Point Vétérinaire (2016), 367

Le sexe ratio (proportion de veaux mâles nés) peut varier sous l’effet de nombreux facteurs (voir l’article dans un numéro précédent). Les mécanismes d’action biologiques expliquant ces variations sont ... [more ▼]

Le sexe ratio (proportion de veaux mâles nés) peut varier sous l’effet de nombreux facteurs (voir l’article dans un numéro précédent). Les mécanismes d’action biologiques expliquant ces variations sont potentiellement nombreux. Tout d’abord l’origine des ovocytes (le sexe ratio varie entre l’ovaire droit et l’ovaire gauche), alors que l’influence de la corne qui héberge le fœtus ne semble pas avoir d’influence. Les spermatozoïdes porteurs du chromosome Y seraient plus rapides mais moins résistants que les spermatozoïdes porteurs du X, expliquant l’influence du moment de l’insémination par rapport à l’ovulation (influence néanmoins non systématiquement observée). La glycémie de la mère orienterait le sexe ratio par un impact sur la maturation ovocytaire et sur le début du développement embryonnaire, les embryons montrant des différences dans leur métabolisme et dans leur résistance au stress. Néanmoins, ces mécanismes restent hypothétiques et mal élucidés. [less ▲]

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See detailMulti-species measurements of nitrogen isotopic composition reveal the spatial constraints and biological drivers of ammonium attenuation across a highly contaminated groundwater system
Wells, Naomi S.; Hakoun, Vivien ULg; Brouyère, Serge ULg et al

in Water Research (2016), 98

Groundwater under industrial sites is characterised by heterogeneous chemical mixtures, making it difficult to assess the fate and transport of individual contaminants. Quantifying the in-situ biological ... [more ▼]

Groundwater under industrial sites is characterised by heterogeneous chemical mixtures, making it difficult to assess the fate and transport of individual contaminants. Quantifying the in-situ biological removal (attenuation) of nitrogen (N) is particularly difficult due to its reactivity and ubiquity. Here a multi-isotope approach is developed to distinguish N sources and sinks within groundwater affected by complex industrial pollution. Samples were collected from 70 wells across the two aquifers underlying a historic industrial area in Belgium. Below the industrial site the groundwater contained up to 1000 mg Nl-1 ammonium (NH4 +) and 300 mg N l-1 nitrate (NO3-), while downgradient concentrations decreased to ~1 mg l-1 DIN ([DIN] = [NH4+-N] + [NO3--N] + [NO2--N]). Mean δ1534 N-DIN increased from ~2‰ to +20‰ over this flow path, broadly confirming that biological N attenuation drove the measured concentration decrease. Multi-variate analysis of water chemistry identified two distinct NH4+ sources (δ15N-NH4+ from -14‰ and +5‰) within the contaminated zone of both aquifers. Nitrate dual isotopes co-varied (δ15 N: -3‰ - +60‰; δ18O: 0‰ - +50‰) within the range expected for coupled nitrification and denitrification of the identified sources. The fact that δ15N-NO2- values were 50‰ to 20‰ less than δ15N-NH4+ values in 40 the majority of wells confirmed that nitrification controlled N turnover across the site. However, the fact that δ15N-NO2- was greater than δ15N-NH4+ in wells with the highest [NH4+] shows that an autotrophic NO2- reduction pathway (anaerobic NH4+ oxidation or nitrifier-denitrification) drove N attenuation closest to the contaminant plume. This direct empirical evidence that both autotrophic and heterotrophic biogeochemical processes drive N attenuation in contaminated aquifers demonstrates the power of multiple N isotopes to untangle N cycling in highly complex systems. [less ▲]

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See detailEuropean Commission, trade agreements, and diversity of cultural expressions: between autonomy and influence
Vlassis, Antonios ULg

in European Journal of Communication (2016), 31(4)

The Convention on diversity of cultural expressions – adopted by United Nations Educational, Scientific and Cultural Organization in 2005 – is a main international instrument within the global governance ... [more ▼]

The Convention on diversity of cultural expressions – adopted by United Nations Educational, Scientific and Cultural Organization in 2005 – is a main international instrument within the global governance of cultural and audiovisual industries. For its part, the European Commission played a critical role in the negotiation, leading to the Convention on Diversity of Cultural Expressions’ adoption. In this respect, the article aims to explore why and how the Commission uses the Convention on Diversity of Cultural Expressions throughout the recent European Union trade negotiations, for which purposes and how the Convention on Diversity of Cultural Expressions influences the European Union foreign policy and its objectives. The article is more concerned with analysing the policy process through which the Commission’s strategy is formulated in light of the Convention on Diversity of Cultural Expressions and of the place of cultural and audiovisual industries within the European Union trade agreements and also concerned with understanding whether the Commission’s autonomy is transformed into influence within the policy process. [less ▲]

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See detailPassive linearization of nonlinear resonances
Habib, Giuseppe ULg; Grappasonni, Chiara ULg; Kerschen, Gaëtan ULg

in Journal of Applied Physics (2016), 120

The objective of this paper is to demonstrate that the addition of properly-tuned nonlinearities to a nonlinear system can increase the range over which a speci c resonance responds linearly. Speci cally ... [more ▼]

The objective of this paper is to demonstrate that the addition of properly-tuned nonlinearities to a nonlinear system can increase the range over which a speci c resonance responds linearly. Speci cally, we seek to enforce two important properties of linear systems, namely the force-displacement proportionality and the invariance of resonance frequencies. Numerical simulations and experiments are used to validate the theoretical ndings. [less ▲]

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See detailThe role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club.
Cavalier, Etienne ULg; Bergmann, P.; Bruyère, Olivier ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2016), 27

The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state ... [more ▼]

The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state of the art on the use of these biomarkers in different clinical or physiological situations like in postmenopausal women, osteoporosis in men, in elderly patients, in patients suffering from bone metastasis, in patients with chronic renal failure, in pregnant or lactating women, in intensive care patients, and in diabetics. We also gave our considerations on the analytical issues linked to the use of these biomarkers, on potential new emerging biomarkers, and on the use of bone turnover biomarkers in the follow-up of patients treated with new drugs for osteoporosis. [less ▲]

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See detailLa radicalité feutrée de la droite espagnole
Molina Marmol, Maïté ULg; Muñoz, Ángeles

in Aide Mémoire (2016), 77

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See detailEntreprise sociale et économie sociale en Asie (Partie I)
Bidet, Eric; Defourny, Jacques ULg; Nyssens, Marthe (eds)

in Revue Internationale de l'Economie Sociale : Recma, Revue des Etudes Coopératives, Mutualistes et Associatives (2016), (n° 341), 21-86

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See detailLe sexe ratio chez les bovins : facteurs de variation
Hanzen, Christian ULg; Chastant-Maillard, Sylvie; Rao, Anne-Sophie ULg et al

in Point Vétérinaire (Le) : Expert Rural (2016), 367

Le sexe ratio secondaire, défini comme la proportion de mâles à la naissance, est de 52% chez les bovins, avec des variations selon les populations étudiées de 46 à 57%. Il est plus élevé lors des ... [more ▼]

Le sexe ratio secondaire, défini comme la proportion de mâles à la naissance, est de 52% chez les bovins, avec des variations selon les populations étudiées de 46 à 57%. Il est plus élevé lors des premières étapes du développement embryonnaire, et les conceptus mâles meurent proportionnellement plus au cours de la gestation que les conceptus femelles. Les facteurs de variation potentiels sont nombreux, mais peu d’effets sont unanimement observés. L’effet de la parité ou du statut social de la vache ne sont pas clairement démontrés. Les ovulations sur l’ovaire droit donneraient naissance à une plus forte proportion de mâles ; le rôle du taureau est probablement limité et la répétabilité du sexe du veau d’une gestation à l’autre est faible. Le moment de l’insémination par rapport à l’ovulation ne semble pas avoir d’influence alors qu’il aurait pu constituer un moyen de maîtrise assez simple à mettre en œuvre. [less ▲]

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See detailThe basis for folinic acid treatment in neuro-psychiatric disorders.
RAMAEKERS, Vincent ULg; Sequeira, J. M.; Quadros, E. V.

in Biochimie (2016), 126

Multiple factors such as genetic and extraneous causes (drugs, toxins, adverse psychological events) contribute to neuro-psychiatric conditions. In a subgroup of these disorders, systemic folate ... [more ▼]

Multiple factors such as genetic and extraneous causes (drugs, toxins, adverse psychological events) contribute to neuro-psychiatric conditions. In a subgroup of these disorders, systemic folate deficiency has been associated with macrocytic anemia and neuropsychiatric phenotypes. In some of these, despite normal systemic levels, folate transport to the brain is impaired in the so-called cerebral folate deficiency (CFD) syndromes presenting as developmental and psychiatric disorders. These include infantile-onset CFD syndrome, infantile autism with or without neurologic deficits, a spastic-ataxic syndrome and intractable epilepsy in young children expanding to refractory schizophrenia in adolescents, and finally treatment-resistant major depression in adults. Folate receptor alpha (FRalpha) autoimmunity with low CSF N(5)-methyl-tetrahydrofolate (MTHF) underlies most CFD syndromes, whereas FRalpha gene abnormalities and mitochondrial gene defects are rarely found. The age at which FRalpha antibodies of the blocking type emerge, determines the clinical phenotype. Infantile CFD syndrome and autism with neurological deficits tend to be characterized by elevated FRalpha antibody titers and low CSF MTHF. In contrast, in infantile autism and intractable schizophrenia, abnormal behavioral signs and symptoms may wax and wane with fluctuating FRalpha antibody titers over time accompanied by cycling changes in CSF folate, tetrahydrobiopterin (BH4) and neurotransmitter metabolites ranging between low and normal levels. We propose a hypothetical model explaining the pathogenesis of schizophrenia. Based on findings from clinical, genetic, spinal fluid and MRI spectroscopic studies, we discuss the neurochemical changes associated with these disorders, metabolic and regulatory pathways, synthesis and catabolism of neurotransmitters, and the impact of oxidative stress on the pathogenesis of these conditions. A diagnostic algorithm and therapeutic regimens using high dose folinic acid, corticosteroids and milk-free diet is presented which has proven to be beneficial in providing adequate folate to the brain and decreasing the FRalpha autoantibody titer in those positive for the antibody. [less ▲]

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See detailExposure to endocrine disrupting chemicals and neurodevelopmental alterations.
Pinson, Anneline ULg; Bourguignon, Jean-Pierre ULg; Parent, Anne-Simone ULg

in Andrology (2016), 4(4), 706-22

The developing brain is remarkably malleable as neural circuits are formed and these circuits are strongly dependent on hormones for their development. For those reasons, the brain is very vulnerable to ... [more ▼]

The developing brain is remarkably malleable as neural circuits are formed and these circuits are strongly dependent on hormones for their development. For those reasons, the brain is very vulnerable to the effects of endocrine-disrupting chemicals (EDCs) during critical periods of development. This review focuses on three ubiquitous endocrine disruptors that are known to disrupt the thyroid function and are associated with neurobehavioral deficits: polychlorinated biphenyls, polybrominated diphenyl ethers, and bisphenol A. The human and rodent data suggesting effects of those EDCs on memory, cognition, and social behavior are discussed. Their mechanisms of action go beyond relative hypothyroidism with effects on neurotransmitter release and calcium signaling. [less ▲]

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See detailSimulation of a two-slope pyramid made by SPIF using an adaptive remeshing method with solid-shell finite element
Velosa De Sena, José ULg; Guzmán Inostroza, Carlos Felipe ULg; Duchene, Laurent ULg et al

in International Journal of Material Forming (2016), 9(3), 259-434

Single point incremental forming (SPIF) is an emerging application in sheet metal prototyping and small batch production, which enables dieless production of sheet metal parts. This research area has ... [more ▼]

Single point incremental forming (SPIF) is an emerging application in sheet metal prototyping and small batch production, which enables dieless production of sheet metal parts. This research area has grown in the last years, both experimentally and numerically. However, numerical investigations into SPIF process need further improvement to predict the formed shape correctly and faster than current approaches. The current work aims the use of an adaptive remeshing technique, originally developed for shell and later extended to 3D “brick” elements, leading to a Reduced Enhanced Solid-Shell formulation. The CPU time reduction is a demanded request to perform the numerical simulations. A two-slope pyramid shape is used to carry out the numerical simulation and modelling. Its geometric difficulty on the numerical shape prediction and the through thickness stress behaviour are the main analysis targets in the present work. This work confirmed a significant CPU time reduction and an acceptable shape prediction accuracy using an adaptive remeshing method combined with the selected solid-shell element. The stress distribution in thickness direction revealed the occurrence of bending/unbending plus stretching and plastic deformation in regions far from the local deformation in the tool vicinity. [less ▲]

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See detailLes mustères de la "Viege noire" ou comment se passe la demande d'allocation de handicap
Marquet, Françoise; RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59(4), 9-13

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See detailIsolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum
Mskhiladze, Lasha; Chincharadze, David; St-Gelais, Alexis et al

in International Journal of Pharmaceutical Sciences and Drug Research (2016), 8(4), 240-243

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers ... [more ▼]

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers of Allium gramineumthat growsin Georgia.The structures of isolated compounds havebeen determined by 1H and 13C nuclear magnetic resonance (NMR) Isolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum. Available from: https://www.researchgate.net/publication/305851744_Isolation_and_Identification_of_Steroid_and_Flavonoid_Glycosides_from_the_Flowers_of_Allium_gramineum [accessed Aug 5, 2016]. [less ▲]

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See detailDynamics of a thin radial liquid flow
De Cock, Nicolas ULg; Massinon, Mathieu ULg; Ouled Taleb Salah, Sofiene ULg et al

in Fire Safety Journal (2016), 83

The present work proposes an extension of the existing analytical development on the radial spread of a liquid jet over a horizontal surface to the case of a thin radial flow. When the gap, H, between the ... [more ▼]

The present work proposes an extension of the existing analytical development on the radial spread of a liquid jet over a horizontal surface to the case of a thin radial flow. When the gap, H, between the jet nozzle and the plate is reduced the discharging area may be smaller than the inlet area leading to an increase of the main flow velocity downstream of the thin cylindrical opening. This increase of velocity, de fined here as 1/alpha , can be related to the relative gap of the nozzle H/R with R the nozzle pipe radius. Numerical computations with a volume of fluid method were realised with for H/R ranging from 0.2 to 3 and with flow rates Q of 3 and 6 l/min1. The results of these computations allowed to express alpha in respect of H/R. Taking in account the flow acceleration allowed to extend the set of equation from the jet impacting flow to the thin cylindrical opening flow. The liquid layer thickness and the surface velocity diff er with a maximum error of 4% between the flow predicted by the model and computations. Main discrepancies appear in the region close to the nozzle where the analytical model assumption of a constant velocity outside the boundary layer is not valid. However, further downstream the model and the computations are in good agreement. [less ▲]

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See detailCyclin-dependent protein kinase inhibitors in breast cancer treatment
FRERES, Pierre ULg; LOUSBERG, Laurence ULg; JERUSALEM, Guy ULg

in Belgian Journal of Medical Oncology [=BJMO] (2016), 10(4), 132-138

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See detailAnalysis of SMOS sea surface salinity data using DINEOF
Alvera Azcarate, Aïda ULg; Barth, Alexander ULg; Parard, Gaëlle ULg et al

in Remote Sensing of Environment (2016), 180

n analysis of daily Sea Surface Salinity (SSS) at 0.15 ° × 0.15° spatial resolution from the Soil Moisture and Ocean Salinity (SMOS) satellite mission using DINEOF (Data Interpolating Empirical Orthogonal ... [more ▼]

n analysis of daily Sea Surface Salinity (SSS) at 0.15 ° × 0.15° spatial resolution from the Soil Moisture and Ocean Salinity (SMOS) satellite mission using DINEOF (Data Interpolating Empirical Orthogonal Functions) is presented. DINEOF allows reconstructing missing data using a truncated EOF basis, while reducing the amount of noise and errors in geophysical datasets. This work represents a first application of DINEOF to SMOS SSS. Results show that a reduction of the error and the amount of noise is obtained in the DINEOF SSS data compared to the initial SMOS SSS data. Errors associated to the edge of the swath are detected in 2 EOFs and effectively removed from the final data, avoiding removing the data at the edges of the swath in the initial dataset. The final dataset presents a centered root mean square error of 0.2 in open waters when comparing with thermosalinograph data at their original spatial and temporal resolution. Constant biases present near land masses, large scale biases and latitudinal biases cannot be corrected with DINEOF because persistent signals are retained in high order EOFs, and therefore these need to be corrected separately. The signature of the Douro and Gironde rivers is detected in the DINEOF SSS. The minimum SSS observed in the Gironde plume corresponds to a flood event in June 2013, and the shape and size of the Douro river shows a good agreement with chlorophyll-a satellite data. These examples show the capacity of DINEOF to remove noise and provide a full SSS dataset at a high temporal and spatial resolution with reduced error, and the possibility to retrieve physical signals in zones with high initial errors. [less ▲]

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See detailThe Influence of Treatment Position (Prone vs. Supine) on Clip Displacement, Seroma, Tumor Bed and Partial Breast Target Volumes: Comparative Study
Lakosi, Ferenc; GULYBAN, Akos ULg; BEN MUSTAPHA, Selma ULg et al

in Pathology Oncology Research (2016), 22(3), 493-500

To analyse the displacement of surgical clips in prone (Pr) position and assess the consequences on target volumes and integral dose of partial breast irradiation (PBI). 30 post-lumpectomy breast cancer ... [more ▼]

To analyse the displacement of surgical clips in prone (Pr) position and assess the consequences on target volumes and integral dose of partial breast irradiation (PBI). 30 post-lumpectomy breast cancer patients underwent CT imaging in supine (Su) and Pr. Clip displacements were measured by the distances from the clips to a common fix bony reference point. On each dataset, the tumour bed (TB = clips ± seroma), clinical target volume (CTV = TB + 1.5 cm) and planning target volumes (PTV = CTV + 1 cm) for PBI were determined and the volume pairs were compared. Furthermore estimation of integral dose ratio (IDR) within the breast from tangential treatment was performed as the ratio of the irradiated breast volume and the volume encompassing all clips. Clips close to the chest wall (CW) in Su showed significantly less displacement in Pr. The mean volumes of seroma, CTV and PTV were significantly higher in Pr than in Su. The PTV volume difference (Pr-Su) was significantly higher in patients with presence of seroma, deep clips and TB location in the superior-internal-quadrant (SIQ) and at the junction of superior quadrants (jSQ). In a multivariate analysis two factors remained significant: seroma and TB localization in SIQ-jSQ. The IDR was significantly larger in Su than in Pr (7.6 vs. 4.1 p < 0.01). Clip displacements varied considerably with respect to their relative position to the CW. In selected patients Pr position potentially leads to a significant increase in target volumes of PBI. Tangential beam arrangement for PBI should be avoided, not only in Su but in Pr as well in case of clip-based target volume definition. [less ▲]

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See detailMathematical modelling of the degradation behaviour of biodegradable metals
Bajger, P; Ashbourn, JMA; Manhas, Varun ULg et al

in Biomechanics & Modeling in Mechanobiology (2016)

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See detailSur Capitalisme, désir et servitude. Lettre à Frédéric Lordon
Pieron, Julien ULg

in Dissensus (2016), 6

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See detailEstimating the out-of-sample predictive ability of trading rules: a robust bootstrap approach
Hambuckers, julien ULg; Heuchenne, Cédric ULg

in Journal of Forecasting (2016), 35(4), 347-372

In this paper, we provide a novel way to estimate the out-of-sample predictive ability of a trading rule. Usually, this ability is estimated using a sample splitting scheme, true out-of-sample data being ... [more ▼]

In this paper, we provide a novel way to estimate the out-of-sample predictive ability of a trading rule. Usually, this ability is estimated using a sample splitting scheme, true out-of-sample data being rarely available. We argue that this method makes a poor use of the available data and creates data mining possibilities. Instead, we introduce an alternative .632 bootstrap approach. This method enables to build in- sample and out-of-sample bootstrap datasets that do not overlap but exhibit the same time dependencies. We show in a simulation study that this technique drastically reduces the mean squared error of the estimated predictive ability. We illustrate our methodology on IBM, MSFT and DJIA stock prices, where we compare 11 trading rules speci cations. For the considered datasets, two different filter rule specifications have the highest out-of-sample mean excess returns. However, all tested rules cannot beat a simple buy-and-hold strategy when trading at a daily frequency. [less ▲]

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See detailAnionic flow polymerizations toward functional polyphosphoesters in microreactors: Polymerization and UV-modification
Baeten, Evelien; Vanslambrouck, Stéphanie; Jérôme, Christine ULg et al

in European Polymer Journal (2016), 80

The polymerization of cyclic phosphates to poly(phosphoester)s, PPEs, is optimized for chip- based microreactors under continuous flow conditions. The anionic ring-opening polymerization of 2-isobutyoxy-2 ... [more ▼]

The polymerization of cyclic phosphates to poly(phosphoester)s, PPEs, is optimized for chip- based microreactors under continuous flow conditions. The anionic ring-opening polymerization of 2-isobutyoxy-2-oxo-1,3,2-dioxaphospholane (iBP) via the use of two organocatalytic systems allowed to polymerize to nearly quantitative monomer conversion within 10 or 3 minutes, respectively at a reaction temperature of 40 °C. Further, the optimized polymerization protocol was applied to 2-butenoxy-2-oxo-1,3,2-dioxaphospholane (BP) which yields a polymer that carries an alkene functionality per monomer repeating unit. This material can be postmodified in an UV-induced radical thiol-ene reaction, which was also shown to proceed with very high efficiency under UV-flow conditions. Eventually, both reactions were coupled in a two-stage reactor setup, showing that the thermally-activated polymerization can be coupled with high efficiency to the UV-activated post-polymerization modification reaction. The introduced reactor setup can in the future be used to produce and screen a broad variety of functional PPE materials with various functionalities and physical properties. [less ▲]

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See detailPhilosophie et esthétique de la modernité: Approches phénoménologiques et sociologiques
Hagelstein, Maud ULg; Zincq, Aurélien ULg

in Bulletin d'Analyse Phénoménologique (2016), 12 (2016)(4),

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See detailSusceptibility of pigs to zoonotic hepatitis E virus genotype 3 isolated from a wild boar
Thiry, Damien ULg; Rose, Nicolas; Mauroy, Axel ULg et al

in Transboundary and Emerging Diseases (2016)

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See detailReduced sputum expression of interferon-stimulated genes in severe COPD.
Hilzendeger, Clarissa ULg; da Silva, Jane; HENKET, Monique ULg et al

in International Journal of Chronic Obstructive Pulmonary Disease (2016), 11

BACKGROUND: Exacerbations of COPD are frequent and commonly triggered by respiratory tract infections. The purpose of our study was to investigate innate immunity in stable COPD patients. METHODS: Induced ... [more ▼]

BACKGROUND: Exacerbations of COPD are frequent and commonly triggered by respiratory tract infections. The purpose of our study was to investigate innate immunity in stable COPD patients. METHODS: Induced sputum was collected from 51 stable consecutive COPD patients recruited from the COPD Clinic of CHU Liege and 35 healthy subjects. Expression of interferons beta (IFN-beta) and lambda1 (IL-29), IFN-stimulated genes (ISGs) MxA, OAS, and viperin were measured in total sputum cells by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The presence of Picornaviruses was assessed by RT-PCR, while potential pathogenic microorganisms (PPM) were identified by sputum bacteriology. RESULTS: Expression of IL-29 was found in 16 of 51 COPD patients (31%) and in nine of 35 healthy subjects (26%), while IFN-beta was detected in six of 51 COPD patients (12%) and in two of 35 healthy subjects (6%). ISGs were easily detectable in both groups. In the whole group of COPD patients, OAS expression was decreased (P<0.05), while that of viperin was increased (P<0.01) compared to healthy subjects. No difference was found with respect to MxA. COPD patients from group D of Global Initiative for Chronic Obstructive Lung Disease (GOLD) had reduced expression of all three ISGs (P<0.01 for MxA, P<0.05 for OAS, and P<0.01 for viperin) as compared to those of group B patients. Picornaviruses were detected in eight of 51 (16%) COPD patients vs four of 33 (12%) healthy subjects, while PPM were detected in seven of 39 (18%) COPD patients and associated with raised sputum neutrophil counts. IFN-beta expression was raised when either picornavirus or PPM were detected (P=0.06), but no difference was seen regarding IL-29 or ISGs. CONCLUSION: ISGs expression was reduced in severe COPD that may favor exacerbation and contribute to disease progress by altering response to infection. [less ▲]

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See detailSafety of Everolimus Plus Exemestane In Patients With Hormone-Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer Progressing on Prior Non-Steroidal Aromatase Inhibitors: Primary Results of a Phase 3b, Open-Label, Single-Arm, Expanded-Access Multicenter Trial (BALLET).
Jerusalem, Guy ULg; Mariani, G.; Ciruelos, E. M. et al

in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO (2016)

BACKGROUND: This European phase 3b, expanded-access multicenter trial evaluated the safety of EVE plus EXE in a patient population similar to BOLERO-2. PATIENTS AND METHODS: Postmenopausal women aged (3 ... [more ▼]

BACKGROUND: This European phase 3b, expanded-access multicenter trial evaluated the safety of EVE plus EXE in a patient population similar to BOLERO-2. PATIENTS AND METHODS: Postmenopausal women aged (3)18 years with hormone receptor-positive, human epidermal growth factor-receptor-2-negative advanced breast cancer (ABC) recurring/progressing during/after prior non-steroidal aromatase inhibitors (NSAIs) were enrolled. Primary objective was safety of EVE plus EXE based on frequency of adverse events (AEs), and serious AEs (SAEs). Secondary objective was to evaluate AEs of grade 3/4 severity. RESULTS: Median treatment duration was 5.1 months (95% CI, 4.8-5.6) for EVE and 5.3 months (95% CI, 4.8-5.6) for EXE. Overall, 2131 patients were included in the analysis; 81.8% of patients experienced EVE- or EXE-related or EVE/EXE-related AEs (investigator assessed); 27.2% were of grade 3/4 severity. The most frequently reported non-hematologic AEs were (overall %, % EVE-related) stomatitis (52.8%; 50.8%) and asthenia (22.8%; 14.6%). The most frequently reported hematologic AE were (overall %, % EVE-related) anemia (14.4%; 8.1%) and thrombocytopenia (5.9%; 4.6%). AE-related treatment discontinuations were higher in elderly ((3)70 years) versus non-elderly patients (23.8% vs. 13.0%). The incidence of EVE-related AEs in both elderly and non-elderly patients appeared to be lower in first-line ABC versus later lines. The incidence of AEs (including stomatitis/pneumonitis) was independent of BMI status (post-hoc analysis). Overall, 8.5% of patients experienced at least one EVE-related SAE. Of the 121 on-treatment deaths (5.7%), 66 (3.1%) deaths were due to disease progression and 46 (2.2%) due to AEs; 4 deaths were suspected to be EVE-related. CONCLUSIONS: This is the largest ever reported safety dataset on a general patient population presenting ABC treated with EVE plus EXE and included a sizeable elderly subset. Although the patients were more heavily pretreated, the safety profile of EVE plus EXE in BALLET was consistent with BOLERO-2. CLINICAL TRIAL REGISTRATION: EudraCT Number: 2012-000073-23. [less ▲]

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See detailLe rôle des pays émergents dans la gouvernance économique mondiale
Wintgens, Sophie ULg; Zacharie, Arnaud ULg

in Annuaire français de Relations internationales (2016), XVII(2016),

Since the 2000s, the rising power of emerging countries – China, East Asian countries and the BRICS in particular – changed the balance of power within the system of global economic governance. In an ... [more ▼]

Since the 2000s, the rising power of emerging countries – China, East Asian countries and the BRICS in particular – changed the balance of power within the system of global economic governance. In an increasingly multipolar world, external policies of the main emerging countries are aimed more at legitimizing their status of regional powers rather than at promoting a truly democratic multilateralism. By doing so, the global shift in wealth puts the multilateralism to the test. Although emerging countries have claimed more room in the international economic organizations, many of their demands have not been heard by the Western traditional powers, which prompted them to launch their own initiatives. This creates an increasing fragmentation of international financial and trade rules, which makes more complex the political conditions for effectively regulate the international system. Although emerging countries have contributed to challenge the legitimacy of the global economic governance architecture, they have so far failed to change its nature or to make it more consistent. [less ▲]

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See detailMaîtrise de la fermentation alcoolique sous stress éthanolique, thermique et osmotique de la souche Saccharomyces cerevisiae YSDN1 en vue de la préparation du vinaigre de fruits
Mounir, Majid ULg; Belgrire, Malika; Lahnaoui, Safaa et al

in Revue Marocaine des Sciences Agronomiques et Veterinaires (2016), 4(2), 86-95

La présente étude a pour but d’isoler, d’identifier et de caractériser de nouvelles souches de levures d’intérêt industriel. Un total de 54 levures ont été isolées et identifiées à partir de produits ... [more ▼]

La présente étude a pour but d’isoler, d’identifier et de caractériser de nouvelles souches de levures d’intérêt industriel. Un total de 54 levures ont été isolées et identifiées à partir de produits agricoles brutes et de sous-produits de l’industrie agro-alimentaire. Parmi ces isolats, quatre souches ont été retenues, purifiées et testées pour leur performance de fermentation sur un jus de dattes de variété Bouslikhène. D’après le séquençage du gène 18S de l’ADN ribosomal, les deux souches YS-DN1 et YS-M isolées respectivement à partir des dattes et de la mélasse ont été identifiées appartenant à l’espèce Saccharomyces cerevisiae. Par ailleurs, les deux autres souches YS-OPM et YS-G isolées des olives et des raisins appartiennent respectivement aux espèces Kluyveromyces marxianus, avec 78% d’homologie et Candida utilis à 89% d’homologie. D’autre part, la souche YS-DN1, s’est identifiée comme la plus performante dans la production d’éthanol en comparaison à deux autres souches industrielles de référence. La levure YS-DN1 était l’unique souche capable de croitre à une température entre 35 et 40°C en présence d’un taux alcoolique élevé et une pression osmotique agressive. Finalement, la production de la biomasse cellulaire de la souche YS -DN1 a été améliorée par optimisation des facteurs température, Brix et pH fixés respectivement à 29.75°C, 15.7% et 4.15. Ces valeurs ont permis d’obtenir un maximum de cellules de l’ordre de 8.4x108 UFC/ml. Il a été conclu que cette souche pourrait bien s’adapter à des usages industriels pour la production du vinaigre de fruits à grande échelle. [less ▲]

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See detailEulerian Formulation of Elastic Rods
Huynen, Alexandre ULg; Detournay, Emmanuel; Denoël, Vincent ULg

in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (2016), 472(2190),

In numerous biological, medical and engineering applications, elastic rods are constrained to deform inside or around tube-like surfaces. To solve efficiently this class of problems, the equations ... [more ▼]

In numerous biological, medical and engineering applications, elastic rods are constrained to deform inside or around tube-like surfaces. To solve efficiently this class of problems, the equations governing the deflection of elastic rods are reformulated within the Eulerian framework of this generic tubular constraint defined as a perfectly stiff canal surface. This reformulation hinges on describing the rod deformed configuration by means of its relative position with respect to a reference curve, defined as the axis or spine curve of the constraint, and on restating the rod local equilibrium in terms of the curvilinear coordinate parameterizing this curve. Associated with a segmentation strategy, which partitions the global problem into a sequence of rod segments either in continuous contact with the constraint or free of contact (except for their extremities), this approach not only trivializes the detection of new contacts but also suppresses the isoperimetric constraints resulting from the self-feeding feature of these elementary problems and the imposition of the rod position at the extremities of each rod segments. [less ▲]

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See detailIntegrating roots into a whole plant network of flowering time genes in Arabidopsis thaliana
Bouché, Frédéric ULg; D'Aloia, Maria; Tocquin, Pierre ULg et al

in Scientific Reports (2016), 6

Molecular data concerning the involvement of roots in the genetic pathways regulating floral transition are lacking. In this study, we performed global analyses of the root transcriptome in Arabidopsis in ... [more ▼]

Molecular data concerning the involvement of roots in the genetic pathways regulating floral transition are lacking. In this study, we performed global analyses of the root transcriptome in Arabidopsis in order to identify flowering time genes that are expressed in the roots and genes that are differentially expressed in the roots during the induction of flowering. Data mining of public microarray experiments uncovered that about 200 genes whose mutations are reported to alter flowering time are expressed in the roots (i.e. were detected in more than 50% of the microarrays). However, only a few flowering integrator genes passed the analysis cutoff. Comparison of root transcriptome in short days and during synchronized induction of flowering by a single 22-h long day revealed that 595 genes were differentially expressed. Enrichment analyses of differentially expressed genes in root tissues, gene ontology categories, and cis-regulatory elements converged towards sugar signaling. We concluded that roots are integrated in systemic signaling, whereby carbon supply coordinates growth at the whole plant level during the induction of flowering. This coordination could involve the root circadian clock and cytokinin biosynthesis as a feed forward loop towards the shoot. [less ▲]

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See detailControlled synthesis of poly(vinylamine)-based copolymers by organometallic-mediated radical polymerization
Dréan, Mathilde ULg; Guégan, Philippe; Detrembleur, Christophe ULg et al

in Macromolecules (2016), 49(13), 4817-4827

iving/controlled polymerization methods have enabled the synthesis of numerous (co)polymers with defined compositions and architectures. However, the precision design of poly(vinylamine)-based copolymers ... [more ▼]

iving/controlled polymerization methods have enabled the synthesis of numerous (co)polymers with defined compositions and architectures. However, the precision design of poly(vinylamine)-based copolymers remains challenging despite their extensive use in various fields of applications and the clear benefits to finely tune their properties. Here, we report on a two-step strategy for the synthesis of tailor-made poly(vinylamine) derivatives through the organometallic- mediated radical (co)polymerization (OMRP) of N-vinyl- acetamide and/or N-methylvinylacetamide followed by acid hydrolysis of the acetamide groups. A series of well-defined homopolymers as well as statistical and block copolymers with pendant primary and/or secondary amines having controlled molar masses, compositions, and low dispersities were produced accordingly. The reactivity ratios of the comonomers as well as the composition drift along the chain were determined in order to have a precise idea of the polymer structures. These advances represent a significant step toward an efficient platform for synthesis of this important class of amino group-containing (co)polymers. [less ▲]

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See detailTransparent superhydrophobic coatings from amphiphilic-fluorinated block copolymers synthesized by aqueous polymerization-induced self-assembly
Ouhib, Farid ULg; Dirani, Ali; Aqil, Abdelhafid ULg et al

in Polymer Chemistry (2016), 7(24), 3998-4003

Preparation of transparent and superhydrophobic coatings by co-deposition of an aqueous solution of an amphiphilic fluorinated block copolymer (FBC) with silica particles was developped. Spin- coating of ... [more ▼]

Preparation of transparent and superhydrophobic coatings by co-deposition of an aqueous solution of an amphiphilic fluorinated block copolymer (FBC) with silica particles was developped. Spin- coating of this aqueous solution onto glass followed by an appropriate thermal treatment promotes the self-assembly of the hybrid material with the formation of superhydrophobic, robust and transparent coatings. [less ▲]

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See detailInteractions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels.
de Vrind, V.; Scuvée-Moreau, Jacqueline ULg; Drion, Guillaume ULg et al

in European Journal of Pharmacology (2016)

Although small-conductance Ca2+-activated K+ (SK) channels and various types of voltage-gated Ca2+ (Cav) channels have been described in midbrain dopaminergic neurons, the nature of their interactions is ... [more ▼]

Although small-conductance Ca2+-activated K+ (SK) channels and various types of voltage-gated Ca2+ (Cav) channels have been described in midbrain dopaminergic neurons, the nature of their interactions is unclear. More particularly, the role of various Cav channel types in either promoting irregularity of firing (by generating an inward current during SK channel blockade) or promoting regularity of firing (by providing the source of Ca2+ for the activation of SK channels) has not been systematically explored. We addressed this question using intracellular and extracellular recordings from substantia nigra, pars compacta (SNc), dopaminergic neurons in rat midbrain slices. Neurons were pharmacologically isolated from their differences. When examining the ability of various Cav channel blockers to inhibit the SK-mediated afterhyperpolarization (AHP), we found that only the N-type Cav channel blocker ω-conotoxin-GVIA was able to reduce the apamin-sensitive AHP, but only partially (~40%). Specific blockers of L, P/Q, T or R channels had no effect on this AHP. Combining ω-conotoxin-GVIA and other specific blockers did not yield greater block and even the broad Cav blocker Cd2+ induced a submaximal (~75%) effect. Extracellular recordings examining firing regularity yielded congruent results: none of the specific blockers was able to increase firing irregularity to the extent that the specific SK blocker apamin did. The irregularity of firing observed with apamin could only be reversed by blocking L-type Ca2+ channels. Thus various sources of Ca2+ appear to be required for SK channel activation in SNc neurons (some of them still unidentified), ensuring robustness of pacemaking regularity. [less ▲]

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See detailOn the coarsening dynamics of a granular lattice gas
Opsomer, Eric ULg; Noirhomme, Martial ULg; Ludewig, François et al

in European Physical Journal E -- Soft Matter (2016)

We investigated experimentally and theoretically the dynamics of a driven granular gas on a square lattice and discovered two characteristic regimes: Initially, given the dissipative nature of the ... [more ▼]

We investigated experimentally and theoretically the dynamics of a driven granular gas on a square lattice and discovered two characteristic regimes: Initially, given the dissipative nature of the collisions, particles move erratically through the system and start to gather on selected sites called traps. Later on, the formation of those traps leads to a strong decrease of the grain mobility and slows down dramatically the dynamics of the entire system. We realize detailed measurements linking a trap’s stability to the global evolution of the system and propose a model reproducing the entire dynamics of the system. Our work emphasizes the complexity of coarsening dynamics of dilute granular systems. [less ▲]

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See detailLa joie qui vient après l'attente. Retour sur la parution de J.-M. Mouillie et J.-P. Narboux, Sartre. L'Être et le néant. Nouvelles lectures, Paris, Les Belles Lettres, 2015, 212 p.
Recchia, Fabio ULg

in Année Sartrienne (L') (2016), 30

Cette publication consiste en une recension des "Nouvelles lectures" de "L'Être et le Néant", publiées à l'occasion de la sélection de ce texte à l'agrégation externe de philosophie 2015. Il s'agit de ... [more ▼]

Cette publication consiste en une recension des "Nouvelles lectures" de "L'Être et le Néant", publiées à l'occasion de la sélection de ce texte à l'agrégation externe de philosophie 2015. Il s'agit de faire retour sur cet événement que constitue la parution d'un tel recueil proposant, selon nous, une "relecture franche" de l'Essai de 1943 - un texte longtemps tenu pour le parent pauvre de la philosophie de Sartre, dans la mesure où cet ouvrage compte peu de monographies spécialisées à son sujet. Identifiant par ailleurs que ces "Nouvelles lectures" renvoient à nouvelle génération de chercheurs, cette recension souligne de quelle manière ce recueil apporte un commentaire lumineux de l'appareillage ontologique de l'Essai de 1943, témoigne en outre d'une attention particulièrement vive à l'égard des thématiques de l'individuation ainsi que de l'intersubjectivité chez Sartre, et articule enfin un dialogue entre les champs des "Études sartriennes" et celui de la philosophie de l'esprit contemporaine. [less ▲]

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See detailEvolution and Distribution of Hydrolytic Enzyme Activities during Preharvest Sprouting of Wheat (Triticum aestivum) in the Field
Olaerts, Heleen; Roye, Chiara; Derde, Liesbeth et al

in Journal of Agricultural and Food Chemistry (2016), 64

To date, research on preharvest sprouted (PHS) wheat has mostly been conducted on kernels germinated under laboratory conditions, which differ widely from conditions in the field. To obtain detailed ... [more ▼]

To date, research on preharvest sprouted (PHS) wheat has mostly been conducted on kernels germinated under laboratory conditions, which differ widely from conditions in the field. To obtain detailed knowledge of the evolution of hydrolytic enzyme activities in PHS wheat Triticum aestivum), a broad collection of samples from three varieties was obtained by harvesting before, at, and after maturity. Delaying harvest time coupled with periods of heavy rainfall caused sprouting in the kernels, observed as a drop in Falling Number and an increase in α-amylase activity. The appearance of α- and β-amylase, peptidase, and endoxylanase activity during field sprouting was independent from each other. Consequently, Falling Number could not be used to predict activity of other hydrolytic enzymes. When differentiating endogenous from kernel-associated microbial enzymes, results showed that α- and β-amylase and peptidase activity of PHS kernels were predominantly of endogenous origin, whereas endoxylanase activity was largely from microbial origin. [less ▲]

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See detailVolumetric capnography: lessons from the past and current clinical applications
VERSCHEURE, Sara ULg; MASSION, Paul ULg; VERSCHUREN, F et al

in Critical Care (2016), 20(1),

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See detailDiaspore heteromorphism in the invasive Bromus tectorum L. (Poaceae): sterile fl orets increase dispersal propensity and distance
Monty, Arnaud ULg; Maebe, Laura ULg; Mahy, Grégory ULg et al

in Flora (2016)

Within a species, the distance travelled by a particular diaspore depends on its morphology. In Poaceae, the presence of terminal sterile florets can lead to diaspore heteromorphism, which may influence ... [more ▼]

Within a species, the distance travelled by a particular diaspore depends on its morphology. In Poaceae, the presence of terminal sterile florets can lead to diaspore heteromorphism, which may influence dispersal. We tested the hypothesis that the presence of sterile florets favored dispersal in Bromus tectorum L., an invasive grass in the Western US. We used field and controlled experiments to study the dispersal of caryopses with and without sterile florets attached (respectively complex and simple diaspores), as well as pieces of inflorescence that detached from the mother plants. We considered both primary and secondary dispersal, as well as abiotic and biotic dispersal agents. The distance travelled by the diaspores and their attachment to animal fur were related to the presence and number of sterile florets. Abiotic agents moved diaspores over relatively short distances, both in terms of primary and secondary dispersal. A significant proportion of diaspores attached to fur, suggesting a potential for dispersal over longdistances. Complex diaspores were better dispersers than simple ones (and pieces of inflorescence), and this pattern was consistent across the study. However, among complex diaspores, the number of sterile florets had little or no influence. Considering primary and secondary dispersal by abiotic and biotic agents provided a general picture of the dispersal ecology of B. tectorum. For all the dispersal steps and dispersal agents we studied, the presence of sterile florets favored dispersal. These results highlight the functional significance of diaspore heteromorphism induced by floret sterility in the dispersal of Poaceae. [less ▲]

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See detailForest Inventory with Terrestrial LiDAR: A Comparison of Static and Hand-Held Mobile Laser Scanning
Bauwens, Sébastien ULg; Bartholomeus, Harm; Calders, Kim et al

in Forests (2016), 7(6), 127

The application of static terrestrial laser scanning (TLS) in forest inventories is becoming more effective. Nevertheless, the occlusion effect is still limiting the processing efficiency to extract ... [more ▼]

The application of static terrestrial laser scanning (TLS) in forest inventories is becoming more effective. Nevertheless, the occlusion effect is still limiting the processing efficiency to extract forest attributes. The use of a mobile laser scanner (MLS) would reduce this occlusion. In this study, we assessed and compared a hand-held mobile laser scanner (HMLS) with two TLS approaches (single scan: SS, and multi scan: MS) for the estimation of several forest parameters in a wide range of forest types and structures. We found that SS is competitive to extract the ground surface of forest plots, while MS gives the best result to describe the upper part of the canopy. The whole cross-section at 1.3 m height is scanned for 91% of the trees (DBH > 10 cm) with the HMLS leading to the best results for DBH estimates (bias of 0.08 cm and RMSE of 1.11 cm), compared to no fully-scanned trees for SS and 42% fully-scanned trees for MS. Irregularities, such as bark roughness and non-circular cross-section may explain the negative bias encountered for all of the scanning approaches. The success of using MLS in forests will allow for 3D structure acquisition on a larger scale and in a time-efficient manner. [less ▲]

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See detailMolecular Alterations and Everolimus Efficacy in Human Epidermal Growth Factor Receptor 2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3.
Andre, Fabrice; Hurvitz, Sara; Fasolo, Angelica et al

in Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2016), 34(18), 2115-24

PURPOSE: Two recent phase III trials, BOLERO-1 and BOLERO-3 (Breast Cancer Trials of Oral Everolimus), evaluated the addition of everolimus to trastuzumab and chemotherapy in human epidermal growth factor ... [more ▼]

PURPOSE: Two recent phase III trials, BOLERO-1 and BOLERO-3 (Breast Cancer Trials of Oral Everolimus), evaluated the addition of everolimus to trastuzumab and chemotherapy in human epidermal growth factor receptor 2-overexpressing advanced breast cancer. The current analysis aimed to identify biomarkers to predict the clinical efficacy of everolimus treatment. METHODS: Archival tumor samples from patients in BOLERO-1 and BOLERO-3 were analyzed using next-generation sequencing, immunohistochemistry, and Sanger sequencing. RESULTS: Biomarker data were available for 549 patients. PIK3CA activating mutations and PTEN loss were reported in 30% and 16% of BOLERO-1 samples and in 32% and 12% of BOLERO-3 samples, respectively. PI3K pathway was hyperactive (PIK3CA mutations and/or PTEN loss and/or AKT1 mutation) in 47% of BOLERO-1 and 41% of BOLERO-3 samples. In both studies, differential progression-free survival (PFS) benefits of everolimus were consistently observed in patient subgroups defined by their PI3K pathway status. When analyzing combined data sets of both studies, everolimus was associated with a decreased hazard of progression in patients with PIK3CA mutations (hazard ratio [HR], 0.67; 95% CI, 0.45 to 1.00), PTEN loss (HR, 0.54; 95% CI, 0.31 to 0.96), or hyperactive PI3K pathway (HR, 0.67; 95% CI, 0.48 to 0.93). Patients with wild-type PIK3CA (HR, 1.10; 95% CI, 0.83 to 1.46), normal PTEN (HR, 1.00; 95% CI, 0.80 to 1.26), or normal PI3K pathway activity (HR, 1.19; 95% CI, 0.87 to 1.62) did not derive PFS benefit from everolimus. CONCLUSION: This analysis, although exploratory, suggests that patients with human epidermal growth factor receptor 2-positive advanced breast cancer having tumors with PIK3CA mutations, PTEN loss, or hyperactive PI3K pathway could derive PFS benefit from everolimus. [less ▲]

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See detailGreenland Ice Sheet seasonal and spatial mass variability from model simulations and GRACE (2003–2012)
Alexander, P.; Tedesco, M.; Schlegel, N-J et al

in Cryosphere (The) (2016), 10

Improving the ability of regional climate models (RCMs) and ice sheet models (ISMs) to simulate spatiotemporal variations in the mass of the Greenland Ice Sheet (GrIS) is crucial for prediction of future ... [more ▼]

Improving the ability of regional climate models (RCMs) and ice sheet models (ISMs) to simulate spatiotemporal variations in the mass of the Greenland Ice Sheet (GrIS) is crucial for prediction of future sea level rise. While several studies have examined recent trends in GrIS mass loss, studies focusing on mass variations at sub-annual and sub-basin-wide scales are still lacking. At these scales, processes responsible for mass change are less well understood and modeled, and could potentially play an important role in future GrIS mass change. Here, we examine spatiotemporal variations in mass over the GrIS derived from the Gravity Recovery and Climate Experiment (GRACE) satellites for the January 2003–December 2012 period using a "mascon" approach, with a nominal spatial resolution of 100 km, and a temporal resolution of 10 days. We compare GRACE-estimated mass variations against those simulated by the Modèle Atmosphérique Régionale (MAR) RCM and the Ice Sheet System Model (ISSM). In order to properly compare spatial and temporal variations in GrIS mass from GRACE with model outputs, we find it necessary to spatially and temporally filter model results to reproduce leakage of mass inherent in the GRACE solution. Both modeled and satellite-derived results point to a decline (of −178.9 ± 4.4 and −239.4 ± 7.7 Gt yr−1 respectively) in GrIS mass over the period examined, but the models appear to underestimate the rate of mass loss, especially in areas below 2000 m in elevation, where the majority of recent GrIS mass loss is occurring. On an ice-sheet-wide scale, the timing of the modeled seasonal cycle of cumulative mass (driven by summer mass loss) agrees with the GRACE-derived seasonal cycle, within limits of uncertainty from the GRACE solution. However, on sub-ice-sheet-wide scales, some areas exhibit significant differences in the timing of peaks in the annual cycle of mass change. At these scales, model biases, or processes not accounted for by models related to ice dynamics or hydrology, may lead to the observed differences. This highlights the need for further evaluation of modeled processes at regional and seasonal scales, and further study of ice sheet processes not accounted for, such as the role of subglacial hydrology in variations in glacial flow. [less ▲]

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See detailOccurrence, fate and risk assessment of personal care products in river-groundwater interface
Serra-Roig, Mª Pau; Jurado Elices, Anna ULg; Diaz-Cruz, M. Silvia et al

in Science of the Total Environment (2016), 568

This work presents the occurrence and fate of selected personal care products (PCPs) in the urban river-groundwater interface. To this end, urban groundwater and river samples were collected in Sant Adrià ... [more ▼]

This work presents the occurrence and fate of selected personal care products (PCPs) in the urban river-groundwater interface. To this end, urban groundwater and river samples were collected in Sant Adrià del Besòs (NE of Spain) and a total of 16 PCPs were analyzed including benzophenone derivatives, camphor derivatives, p-aminobenzoic acid derivatives, triazoles and parabens in three different campaigns (from May 2010 to July 2014). These compounds reach the aquifer through the recharge of River Besòs that receives large amounts of effluents from waste water treatment plants. Results shown that most of compounds were not or barely detected (maximum concentrations around 30 ng/L) in groundwater samples during the different sampling campaigns. Only two triazoles, named as benzotriazole (BZT) and methyl benzotriazol (MeBZT) were found at high concentrations in groundwater samples (maximum concentration around 2000 ng/L). The fate of PCPs in the aquifer was assessed using mixing analysis considering the temporal variability of the River Besòs. Overall, measured groundwater concentrations were significantly much lower than those estimated by the mixing of the river water. This observation suggested that most of the PCPs are naturally removed when river water infiltrates the aquifer. However, some compounds were more persistent in the aquifer. These compounds were in descending order: the triazoles MeBZT and BZT followed by the camphor derivative 4MBC. The measured concentrations allowed us to assess the environmental risk posed by the selected UV-Fs (e.g. benzophenone derivatives) in the river-groundwater samples. Hazard Quotients (HQs) for diferent aquatic species were calculated in order to characterise the ecotoxicity potential of the studied compounds in the river-groundwater interface. HQ values will be presented and discussed in the presentation. [less ▲]

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See detailRemotely-sensed detection of effects of extreme droughts on gross primary production.
Vicca, Sara; Balzarolo, Manuela; Filella, Iolanda et al

in Scientific Reports (2016), 6

Severe droughts strongly impact photosynthesis (GPP), and satellite imagery has yet to demonstrate its ability to detect drought effects. Especially changes in vegetation functioning when vegetation state ... [more ▼]

Severe droughts strongly impact photosynthesis (GPP), and satellite imagery has yet to demonstrate its ability to detect drought effects. Especially changes in vegetation functioning when vegetation state remains unaltered (no browning or defoliation) pose a challenge to satellite-derived indicators. We evaluated the performance of different satellite indicators to detect strong drought effects on GPP in a beech forest in France (Hesse), where vegetation state remained largely unaffected while GPP decreased substantially. We compared the results with three additional sites: a Mediterranean holm oak forest (Puéchabon), a temperate beech forest (Hainich), and a semi-arid grassland (Bugacpuszta). In Hesse, a three-year reduction in GPP following drought was detected only by the Enhanced Vegetation Index (EVI). The Photochemical Reflectance Index (PRI) also detected this drought effect, but only after normalization for absorbed light. In Puéchabon normalized PRI outperformed the other indicators, while the short-term drought effect in Hainich was not detected by any tested indicator. In contrast, most indicators, but not PRI, captured the drought effects in Bugacpuszta. Hence, PRI improved detection of drought effects on GPP in forests and we propose that PRI normalized for absorbed light is considered in future algorithms to estimate GPP from space. [less ▲]

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