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See detailLICHEN ET DERMATOSES LICHENOIDES - SPECTRE CLINIQUE ET BREF RAPPEL DE LA PRISE EN CHARGE
COLSON, Fany ULg; CAO, Sandrine ULg; MANSUY, Marion ULg et al

in SKIN (2016)

Bien connu dans sa forme typique, le lichen peut présenter des visages très variés dans ses formes atypiques (1-4). La reconnaissance de celles-ci est importante pour orienter le diagnostic et la prise en ... [more ▼]

Bien connu dans sa forme typique, le lichen peut présenter des visages très variés dans ses formes atypiques (1-4). La reconnaissance de celles-ci est importante pour orienter le diagnostic et la prise en charge. le mot lichen vient du Grec et signifie plante parasite. Le lichen a été décrit pour la première fois sous le nom de "lichen ruber" par Ferdinand Von Hebra en 1860. En effet, le réseau blanchâtre à la surface des lésions papuleuses ressemble au champignon lichen qui forme une symbiose avec un partenaire capable de photosynthèse (souvent une algue verte), généralement observée à la surface des rochers. L'appellation "lichen planus" a été proposée par Erasmus Wilson en 1866. Le lichen constitue le prototype de dermatoses lichénoïdes (Tableau 1). Ces maladies inflammatoires sont caractérisées, d'un point de vue clinique, par des lésions papuleuses et, d'un point de vue histologique, par un dense infiltrat lymphocytaire en bande dans le derme superficiel avec lésions des couches kératinocytaires inférieures de l'épiderme. [less ▲]

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See detailLes croyances délétères des patients lombalgiques : revue narrative de la littérature
Demoulin, Christophe ULg; Roussel, Nathalie; Marty, Marc et al

in Revue Médicale de Liège (2016), 71(1), 40-46

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See detailThe colonisation history of British water vole (Arvicola amphibius [L., 1758]): origins and development of the Celtic Fringe
Brace, Selina; Ruddy, Mark; Miller, Rebecca ULg et al

in Proceedings of the Royal Society B : Biological Sciences (2016)

The terminal Pleistocene and Early Holocene, a period from 15 000 to 18 000 Before Present (BP), was critical in establishing the current Holarctic fauna, with temperate-climate species largely replacing ... [more ▼]

The terminal Pleistocene and Early Holocene, a period from 15 000 to 18 000 Before Present (BP), was critical in establishing the current Holarctic fauna, with temperate-climate species largely replacing cold-adapted ones at midlatitudes. However, the timing and nature of this process remain unclear for many taxa, a point that impacts on current and future management strategies. Here, we use an ancient DNA dataset to test more directly postglacial histories of the water vole (Arvicola amphibius, formerly A. terrestris), a species that is both a conservation priority and a pest in different parts of its range. We specifically examine colonization of Britain, where a complex genetic structure can be observed today. Although we focus on population history at the limits of the species’ range, the inclusion of additional European samples allows insights into European postglacial colonization events and provides a molecular perspective on water vole taxonomy. [less ▲]

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See detailTemporal evolution of sand corridors in a Posidonia oceanica seascape: a 15-years study
Gobert, Sylvie ULg; Lepoint, Gilles ULg; Pelaprat, Corinne et al

in Mediterranean Marine Science (2016), 17(3), 777-784

The spatial dynamic of Posidonia oceanica meadows is a process extending over centuries. This paper shows evidence of the natural dynamics of P. oceanica “shifting intermattes” or “sand corridors” ... [more ▼]

The spatial dynamic of Posidonia oceanica meadows is a process extending over centuries. This paper shows evidence of the natural dynamics of P. oceanica “shifting intermattes” or “sand corridors” (hereafter SCs): unvegetated patches within a dense meadow. We studied features and temporal evolution (2001-2015) of 5 SCs in the Calvi Bay (Corsica) at 15 m depth and followed the characteristics the P. oceanica meadow lining the edge of patches. All SCs show a similar morphology. The eroded side is a vertical edge where roots, rhizomes and sediments are visible, when on the opposite colonized side, the sand is at the same level as the continuous meadow. The vertical edge reaches a maximum height of 160 cm and is eroded by orbital bottom currents with a maximum speed of 12 cm.s-1, the erosion speed ranging from 0.6 to 15 cm.y-1. SCs progress toward the coastline with a mean speed of 10 cm.y-1, the rate of colonization by P. oceanica shoots ranging from 1.5 to 21 cm.y-1. We calculated that the studied SCs would reach the coastline within 500 to 600 years. We finally discuss the implication of such dynamic in the framework of meadows’ colonization assessment and the seascape dynamic. [less ▲]

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See detailEffect of chondroitin sulfate on soluble biomarkers of osteoarthritis: a method to analyze and interpret the results from an open-label trial in unilateral knee osteoarthritis patients.
Moller, Ingrid; Gharbi, Myriam; Martinez Serrano, Helena et al

in BMC Musculoskeletal Disorders (2016), 17(1), 416

BACKGROUND: The aim of this study was to investigate the effects of chondroitin sulfate (CS) on the serum levels of Coll2-1 in patients with knee OA. METHODS: Seventy two patients with unilateral ... [more ▼]

BACKGROUND: The aim of this study was to investigate the effects of chondroitin sulfate (CS) on the serum levels of Coll2-1 in patients with knee OA. METHODS: Seventy two patients with unilateral symptomatic knee OA were involved in a post-authorization open-label study evaluating CS (800 mg/day). The primary outcome was the % relative change in serum Coll2-1 (sColl2-1). The secondary outcomes were the evaluation of pain (VAS) and function (Lequesne's Index). Responders and non-responders were classified according to OMERACT-OARSI recommendations. Finally, an original cut-off method was applied to categorize patients and interpret individual variations in serum levels of Coll2-1. RESULTS: Patients showed no difference in the sColl2-1 levels at baseline. When considering responders and non-responders from the ITT population, a significant difference was found for Coll2-1 at 3 months (p = 0.030) and 6 months (p = 0.038). A decrease in pain (VAS) and an improvement in function (LI) were recorded throughout the visits (p < 0.01). Considering an intra-batch cut-off of 21 %, CS decreased Coll2-1 serum levels between baseline and 1-month visit compared to the value of Coll2-1 before treatment (screening visit) which can be interpreted as a drastic reduction of the proportion of patients with an increase of Coll2-1 over 21 % (reduction from 13 to 3 %). It also consisted in a more important proportion of patients with a decrease in Coll2-1 (from 5 to 10 %). CONCLUSION: This study proposes a new approach for the analysis and the interpretation of the individual variation in biomarker levels and introduces the notion of metabolic responders. TRIAL REGISTRATION: ID ISRCTN63795830 . The trial was retrospectively registered on 2 October, 2015. [less ▲]

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See detailStructural Proteomics of Herpesviruses.
Leroy, Baptiste; Gillet, Laurent ULg; Vanderplasschen, Alain ULg et al

in Viruses (2016), 8(2),

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have ... [more ▼]

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have been unsuccessful because these viruses have developed numerous immune evasion mechanisms. Therefore, a better understanding of their complex lifecycle is needed. In particular, while the genome of numerous herpesviruses has been sequenced, the exact composition of virions remains unknown for most of them. Mass spectrometry has recently emerged as a central method and has permitted fundamental discoveries in virology. Here, we review mass spectrometry-based approaches that have recently allowed a better understanding of the composition of the herpesvirus virion. In particular, we describe strategies commonly used for proper sample preparation and fractionation to allow protein localization inside the particle but also to avoid contamination by nonstructural proteins. A collection of other important data regarding post-translational modifications or the relative abundance of structural proteins is also described. This review also discusses the poorly studied importance of host proteins in herpesvirus structural proteins and the necessity to develop a quantitative workflow to better understand the dynamics of the structural proteome. In the future, we hope that this collaborative effort will assist in the development of new strategies to fight these infections. [less ▲]

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See detailOptimal configurations of the Deep Underground Neutrino Experiment
Barger, Vernon; Bhattacharya, Atri ULg; Animesh, Chatterjee et al

in International Journal of Modern Physics A : Particles & Fields, Gravitation, Cosmology, Nuclear Physics (2016), A31(07), 1650020

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See detailPreliminary studies on Imbrasia oyemensis, a valuable non-wood forest productinCameroon
Tabi Eckebil, Paule Pamela; Verheggen, François ULg; Sonwa, Denis Jean et al

in Nature et Faune (2016), 30(2), 73-78

La consommation d’insectes occupe une grande place dans le domaine de la sécurité alimentaire des peuples d’Afrique, d’Asie et d’Amérique latine. Imbrasia oyemensis (Saturniidae) est une chenille ... [more ▼]

La consommation d’insectes occupe une grande place dans le domaine de la sécurité alimentaire des peuples d’Afrique, d’Asie et d’Amérique latine. Imbrasia oyemensis (Saturniidae) est une chenille comestible, classée comme Produit Forestier Non Ligneux (PFNL). Elle est inféodée à Entandrophragma cylindricum dénommé « Sapelli », classée parmi les principales essences de bois d’œuvre d’Afrique centrale destinée à l’export. L’exploitation de cette essence de bois d’œuvre pourrait donc être concurrentielle pour les populations locales, qui pourraient se trouver privées de cette ressource non ligneuse qu’est la chenille. Ce papier présente les résultats préliminaires d’une étude qui visait à déterminer les caractéristiques morphologiques des arbres impliquées dans la sélection du site de ponte des papillons. Les larves d’I.oyemensis se retrouvent principalement sur des individus co-dominant ou dominant ayant déjà atteint le diamètre de fructification régulière. Ces résultats fournissent des pistes utiles comme point de départ aux études sur l’écologie de la chenille en relation avec son arbre hôte. [less ▲]

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See detailA principle of similarity for nonlinear vibration absorbers
Habib, Giuseppe ULg; Kerschen, Gaëtan ULg

in Physica D: Nonlinear Phenomena (2016), 332

This paper develops a principle of similarity for the design of a nonlinear absorber, the nonlinear tuned vibration absorber (NLTVA), attached to a nonlinear primary system. Specifically, for effective ... [more ▼]

This paper develops a principle of similarity for the design of a nonlinear absorber, the nonlinear tuned vibration absorber (NLTVA), attached to a nonlinear primary system. Specifically, for effective vibration mitigation, we show that the NLTVA should feature a nonlinearity possessing the same mathematical form as that of the primary system. A compact analytical formula for the nonlinear coefficient of the absorber is then derived. The formula, valid for any polynomial nonlinearity in the primary system, is found to depend only on the mass ratio and on the nonlinear coefficient of the primary system. When the primary system comprises several polynomial nonlinearities, we demonstrate that the NLTVA obeys a principle of additivity, i.e., each nonlinear coefficient can be calculated independently of the other nonlinear coefficients using the proposed formula. [less ▲]

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See detailHuman norovirus infection in Latin America
da Silva Polo, Tatiane; Peiro, Juliana; Claudio Nogueira Mendes, Luiz et al

in Journal of Clinical Virology (2016), 78

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See detailSulfur solubility in reduced mafic silicate melts: Implications for the speciation and distribution of sulfur on Mercury
Namur, Olivier; Charlier, Bernard ULg; Holtz, Francois et al

in Earth and Planetary Science Letters (2016), 448

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See detailNeural correlates of event clusters in past and future thoughts: How the brain integrates specific episodes with autobiographical knowledge
Demblon, Julie ULg; Bahri, Mohamed Ali ULg; D'Argembeau, Arnaud ULg

in NeuroImage (2016), 127

When remembering the past or envisioning the future, events often come to mind in organized sequences or stories rather than in isolation from one another. The aim of the present fMRI study was to ... [more ▼]

When remembering the past or envisioning the future, events often come to mind in organized sequences or stories rather than in isolation from one another. The aim of the present fMRI study was to investigate the neural correlates of such event clusters. Participants were asked to consider pairs of specific past or future events: in one condition, the two events were part of the same event cluster (i.e., they were thematically and/or causally related to each other), whereas in another condition the two events only shared a surface feature (i.e., their location); a third condition was also included, in which the two events were unrelated to each other. The results showed that the processing of past and future events that were part of a same cluster was associated with higher activation in the medial prefrontal cortex (PFC), rostrolateral PFC, and left lateral temporal and parietal regions, compared to the two other conditions. Furthermore, functional connectivity analyses revealed an increased coupling between these cortical regions. These findings suggest that largely similar processes are involved in organizing events in clusters for the past and the future. The medial and rostrolateral PFC might play a pivotal role in mediating the integration of specific events with conceptual autobiographical knowledge ‘stored’ in more posterior regions. Through this integrative process, this set of brain regions might contribute to the attribution of an overarching meaning to representations of specific past and future events, by contextualizing them with respect to personal goals and general knowledge about one's life story. [less ▲]

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See detailLa empresa social en Bélgica: diversidad de fuentes, modelos y campos
Huybrechts, Benjamin ULg

in Revista de la Academia (2016), 21

Este artículo está estructurado como sigue: la primera sección introductoria revisa las principales raíces históricas que han conduci- do a la emergencia de una diversidad de modelos relacionados con la ... [more ▼]

Este artículo está estructurado como sigue: la primera sección introductoria revisa las principales raíces históricas que han conduci- do a la emergencia de una diversidad de modelos relacionados con la empresa social y a la economía social en Bélgica. Enseguida, la segunda sección esboza los principales aspectos de esos modelos en relación a sus formas legales, tipos de misión social a las que se orientan, dinámicas de gobierno y recursos. En la tercera sección, esos modelos son ilustrados in diferentes campos de actividad, tanto establecidos como emergentes. Finalmente, la cuarta sección propone un análisis transversal de los principales tendencias y desafíos que enfrenta el desarrollo y coexisten- cia de los diferentes modelos. [less ▲]

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See detailLumbopelvic motor control and low back pain in elite soccer players: a cross-sectional study
GROSDENT, Stéphanie ULg; Demoulin, Christophe ULg; Rodriguez de la Cruz, Carlos ULg et al

in Journal of Sports Sciences (2016)

This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1 ... [more ▼]

This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1.4 years) filled in questionnaires related to low back pain and attended a session to assess lumbopelvic motor control by means of five tests (the bent knee fall out test, the knee lift abdominal test, the sitting knee extension test, the waiter ’ s bow and the transversus abdominis test). A physiotherapist, blinded to the medical history of the participants, scored (0 = failed, 1 = correct) the performance of the players for each of the tests resulting in a lumbopelvic motor control score ranging from 0 to 5. Forty-seven per cent of the soccer players reported a disabling low back pain episode lasting at least two consecutive days in the previous year. These players scored worse lumbopelvic motor control than players without a history of low back pain (lumbopelvic motor control score of 1.8 vs. 3.3, P < 0.01). The between-groups difference was particularly marked for the bent knee fall out test, the knee lift abdominal test and the transversus abdominis test (P < 0.01). In conclusion, most soccer players with a history of low back pain had an altered lumbopelvic motor control. Further research should examine whether lumbopelvic motor control is etiologically involved in low back pain episodes in soccer players. [less ▲]

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See detailTRANSCUTANEOUS OCCIPITAL NERVE STIMULATION AND TRANSCRANIAL DIRECT CURRENT STIMULATION IN CHRONIC MIGRAINE: A PILOT COMPARISON OF THERAPEUTIC AND ELECTROPHYSIOLOGICAL EFFECTS
MAGIS, Delphine ULg; D'Ostilio, Kevin ULg; Baschi et al

in Cephalalgia : An International Journal of Headache (2016), 36(1S), 31

Background: Management of chronic migraine (CM) is often challenging. There is a need for more effective and better-tolerated preventive therapies. Among non-invasive neurostimulation procedures ... [more ▼]

Background: Management of chronic migraine (CM) is often challenging. There is a need for more effective and better-tolerated preventive therapies. Among non-invasive neurostimulation procedures, transcutaneous occipital nerve stimulation (tONS) would act via central pain modulation, while transcranial direct current stimulation (tDCS) would modify cortical excitability that is abnormal in CM. Objectives: In this pilot trial we compared the clinical effects of tDCS and tONS in refractory CM and their ability to modify nociception and cortical responsiveness. Methods: Forty-three CM patients (17 with history of drug overuse) applied either 2mA tDCS during 2 months (N¼20, cathode over visual cortex, anode over left DLPFC), or tONS during 3 months (N¼23, Cefaly Kit ArnoldTM), both in daily 20 min-sessions. Visual evoked potentials (VEP), nociceptive blink reflexes (nBR) and quantitative sensory testing were recorded before and after treatment. Results: During the last stimulation month, total headache days decreased in both groups ( 16.4% for tDCS, 17% for tONS, p<0.05). Migraine days were reduced by 21.4% (p¼0.06) and 22% (p<0.05) respectively, while 30% responder rates were 47% and 42%. Medication intake was significantly reduced after tONS ( 43%). There was no significant change of nBR in either group. VEP habituation reversed to an episodic migraine pattern, i.e. a deficit, after tONS but not after tDCS. Conclusion: tONS and inhibitory tDCS of the visual cortex are interesting non-invasive options for the treatment of CM, but these results have to be confirmed in a randomized controlled trial. tONS was able to induce recordable changes in visual cortex responsiveness [less ▲]

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See detailHeterogeneous bedrock investigation for a closed-loop geothermal system: A case study
Radioti, Georgia ULg; Delvoie, Simon ULg; Charlier, Robert ULg et al

in Geothermics (2016)

This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The ... [more ▼]

This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The investigated site consists of four boreholes equipped with geothermal pipes on the campus of University of Liege, Belgium. The first approach includes acoustic borehole imaging, gamma-ray logging and cuttings observation and results to a detailed fracture characterisation, rock identification and layer dip angle determination. The second approach consists of measuring the thermal conductivity of cuttings at the laboratory. Study of cuttings thermal conductivity measurements can contribute to bedrock heterogeneity knowledge concerning the transition of one formation to another and the layer dipping. The third approach is based on high-resolution temperature profiles, measured during the hardening of the grouting material and the recovery phase of a Distributed Thermal Response Test. Through this approach a correlation of the temperature profiles to the geological characteristics of the surrounding bedrock is identified. The analysis of this correlation can provide information on fractured zones, alternation of different rock types and layering dipping. This latter approach can be easily applied on closed-loop geothermal systems to characterise the bedrock and investigate its heterogeneity as well as contribute to the their long-term behaviour prediction and to the optimisation of their efficiency. [less ▲]

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See detailPhotocatalytic decolorization of Gentian Violet with Na-doped (SnO2 and ZnO)
Benhebal, Hadj; Chaib, Messaoud; Crine, Michel ULg et al

in Chiang Mai Journal of Sciences (2016), 42

Photocatalysis is a technique used for the purification and decolorization of water. In this work, the photocatalytic decolorization of aqueous solutions of Gentian Violet has been investigated. The ... [more ▼]

Photocatalysis is a technique used for the purification and decolorization of water. In this work, the photocatalytic decolorization of aqueous solutions of Gentian Violet has been investigated. The photocatalysts used for the study are tin dioxide (SnO2) and zinc oxide (ZnO) doped with sodium and prepared by sol-gel process. Photocatalysts were synthesised by sol-gel process and characterized by several techniques such as X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer, Emmett and Teller (BET) method and UV-vis Spectroscopy. The results of photocatalytic activity of gentian violet degradation under ultraviolet irradiation, indicated that the synthesised photocatalyst exhibit good photocatalytic performance. [less ▲]

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See detailCassini in situ observations of long duration magnetic reconnection in Saturn’s magnetotail
Arridge, C.S.; Eastwood, J.P.; Jackman, C.M. et al

in Nature (2016)

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See detailProbing the low-frequency vortex dynamics in a nanostructured superconducting strip
de Souza Silva, Clecio C.; Raes, Bart; Brisbois, Jérémy ULg et al

in Physical Review B (2016)

We investigate by scanning susceptibility microscopy the response of a thin Pb strip, with a square array of submicron antidots, to a low-frequency ac magnetic field applied perpendicularly to the film ... [more ▼]

We investigate by scanning susceptibility microscopy the response of a thin Pb strip, with a square array of submicron antidots, to a low-frequency ac magnetic field applied perpendicularly to the film plane. By mapping the local permeability of the sample within the field range where vortices trapped by the antidots and interstitial vortices coexist, we observed two distinct dynamical regimes occurring at different temperatures. At a temperature just below the superconducting transition, T/Tc = 0.96, the sample response is essentially dominated by the motion of highly mobile interstitial vortices. However, at a slightly lower temperature, T/Tc = 0.93, the interstitial vortices freeze up leading to a strong reduction of the ac screening length. We propose a simple model for the vortex response in this system which fits well to the experimental data. Our analysis suggests that the observed switching to the high mobility regime stems from a resonant effect, where the period of the ac excitation is just large enough to allow interstitial vortices to thermally hop through the weak pinning landscape produced by random material defects. This argument is further supported by the observation of a pronounced enhancement of the out-of-phase response at the crossover between both dynamical regimes. [less ▲]

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See detailTargeting the tricuspid valve: A new therapeutic challenge.
LANCELLOTTI, Patrizio ULg; Fattouch, Khalil; DULGHERU, Raluca Elena ULg

in Archives of cardiovascular diseases (2016)

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See detailExperimental Neospora caninum infection modifies trophoblast cell populations and plasma pregnancy-associated glycoprotein 1 and 2 dynamics in pregnant dairy heifers.
Mur-Novales, R.; Serrano-Perez, B.; Garcia-Ispierto, I. et al

in Veterinary parasitology (2016), 216

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast ... [more ▼]

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast cells, are used for pregnancy diagnosis and as a marker of foetal-placental well-being, while PAG-2, produced by both mono- and binucleate trophoblast cells, may serve as an indicator of abortion risk. In prior work, natural N. caninum infection was found to modify plasma PAG-1 and PAG-2 patterns. The present study examines PAG-1 and PAG-2 dynamics and trophoblast cell populations following experimental infection with N. caninum. The study population was comprised of 17 N. caninum seronegative Holstein-Friesian heifers. On day 110 of gestation, 6 heifers were inoculated intravenously with 10(7) taquyzoites of N. canimum. Plasma samples for PAG-1 and PAG-2 determinations were collected on days 0, 7, 14, 21 and 42 post infection. During the study course, pregnancy was normally expressed in all controls while three infected heifers lost their foetuses. All heifers were euthanised on day 42 post infection and placentome samples from the 14 non-aborting heifers were collected to examine trophoblast cell populations. Plasma PAG-1 and PAG-2 concentrations in non-infected heifers increased until the day of euthanasia while non-aborting infected heifers showed a temporary fall in PAG-1 (P<0.004) and PAG-2 (P<0.002) concentrations from 7 to 14 days post infection (dpi). The two dams aborting at 14 and 21 dpi and a third dam with a mummified foetus upon euthanasia showed dramatic PAG-1 and PAG-2 reductions from 14 dpi to undetectable levels upon euthanasia. A stereological study of placentomes revealed significantly higher relative proportions of mono- (P=0.035) and binucleate (P=0.029) trophoblast cells at 42 dpi in non-infected heifers than infected non-aborting heifers. According to our findings, following experimental N. caninum infection on day 110 of gestation, non-aborting heifers showed a brief reversible drop in plasma PAG-1 and 2 concentrations two weeks later and reduced proportions of bi- and mono-nucleate trophoblast cells 42 days after infection. In aborting dams, dramatically reduced PAG levels were related to severe placental damage and a non-viable pregnancy. [less ▲]

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See detailCopper tolerance of three Crotalaria species from southeastern D.R. Congo at the early development stage [Tolérance au cuivre de trois espèces de Crotalaria de l’Arc Cuprifère Katangais dans les premiers stades de croissance]
Boisson, Sylvain ULg; Le Stradic, Soizig ULg; Commans, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(2), 151-160

Description of the subject. Microevolutionary processes in metallophytes established on copper enriched soils can lead to a diversity of plant species showing distinct tolerance capacities among genus ... [more ▼]

Description of the subject. Microevolutionary processes in metallophytes established on copper enriched soils can lead to a diversity of plant species showing distinct tolerance capacities among genus. Researches about the relationship between these endangered plants and soil copper concentrations are critical in order to improve ex situ conservation methods in southeastern Democratic Republic of Congo (Katangan Copperbelt). Objectives. The aim of the study was to test the effect of copper on the germination and root elongation of three Crotalaria species naturally occurring along a natural copper gradient. The hypothesis is that copper concentrations have different effects on germination and root elongation according to the species of Crotalaria genus. Method. Three species were selected: Crotalaria cobalticola, Crotalaria peschiana and Crotalaria cornetii, occurring on soils with the highest to the lowest copper concentrations respectively. Germination and root elongation tests were performed in vitro (MS vitamin-enriched medium) in six copper mediums ranging from 0 to 125 μM Cu2+. Results. No significant differences in germination percentage were observed according to the copper concentrations. Crotalaria cornetii had the lowest germination percentage. Root elongation of C. peschiana did not differ with copper concentration, but root elongation of C. cobalticola was higher at the greatest copper concentration (125 μM Cu2+). Conclusions. Even if C. cobalticola presented better growth at highest Cu concentrations, it appeared that C. cobalticola and C. peschiana do not require copper for their early stages of development and could thus be conserved in non-contaminated substrate. Crotalaria cornetii seemed to present a physical seed dormancy. © 2016, FAC UNIV SCIENCES AGRONOMIQUES GEMBLOUX. All rights reserved. [less ▲]

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See detailTrophic ecology of the seagrass-inhabiting footballer demoiselle Chrysiptera annulata (Peters, 1855); comparison with three other reef-associated damselfishes
Lepoint, Gilles ULg; Michel, Loïc ULg; Parmentier, Eric ULg et al

in Belgian Journal of Zoology (2016), 146(1), 21-32

Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming ... [more ▼]

Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming behavior, from almost non territorial to monoculture farmers. In addition, few species inhabit seagrass meadows but, presently, none can be considered as seagrass-eating specialists. The footballer demoiselle, Chrysiptera annulata, is found in the seagrass meadows on the reef flat of the Great Reef of Toliara (Madagascar, Mozambique Channel). Regarding this unusual habitat for pomacentrid, this study aimed to answer 3 questions: 1) What is the diet of C. annulata? 2) Do the resources supporting this diet include seagrass? 3) Does its trophic niche overlap those of other sympatric damselfishes (Pomacentrus trilineatus, Chrysiptera unimaculata and Plectroglyphidodon lacrymatus) living in close association with macrophytes or eating algae? Stomach content examination and stable isotope analysis showed that the footballer demoiselle is not a seagrass consumer but is an omnivorous/herbivorous species heavily relying on algal resources and small invertebrates. SIAR, a stable isotope mixing model, indicated it assimilated large amount of turf algae and various benthic or planktonic invertebrates in lower proportions. SIBER metrics pointed out that isotopic niche of the footballer demoiselle partly overlaps the one of its congeneric C. unimaculata, but not those of P. trilineatus and P. lacrymatus. Trophic strategies of C. annulata differed both from farming species such as P. lacrymatus or from less territorial herbivores such as P. trilineatus. Its seagrass meadow habitat on the Great Reef of Toliara allow the conquest of an unusual habitat for damselfishes and could limit competition with C. unimaculata, a species displaying the same territorial behavior and the same isotopic niche but living on the reef itself. [less ▲]

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See detailA MACHINE-LEARNING CLASSIFIER FOR EPISODIC MIGRAINE BASED ON VISUAL EVOKED GAMMA BAND ACTIVITY
D'Ostilio, Kevin ULg; Lisicki Martinez, Marco ULg; SCHOENEN, Jean ULg et al

in Cephalalgia : An International Journal of Headache (2016), 36(1S), 56

Introduction: Objective and reliable biomarkers of migraine may be of interest for diagnosis and research purposes. Neuroimaging-based machine-learning classifiers are promising but hampered by ... [more ▼]

Introduction: Objective and reliable biomarkers of migraine may be of interest for diagnosis and research purposes. Neuroimaging-based machine-learning classifiers are promising but hampered by availability and cost issues. Conversely, evoked potential are of easy access and affordable. They have provided increasing evidence that sensory information processing is impaired in migraine. We have used gamma band oscillations (GBOs) of visual evoked potentials (VEPs) to compute a machine-learning neural network classifier in episodic migraine. Materials and methods: We analyzed GBOs from VEPs (6x100 responses). Recordings were performed in two matched samples: a training sample composed of 43 migraine patients (EM) and 20 healthy volunteers (HV) and a validating sample of 18 EM and 10 HV. A logistic regression model of the training sample was performed to evaluate the relevance of the predictor variables. Ten neural networks were automatically generated based on late component frequency, n3-p4 and p4-n4 slopes, 1st block n1-p2 amplitude and age. Results: The logistic regression model of the training sample reached a significant classification rate of 79% (EM: 88%; HV: 60%, p¼0.002). The best neural network was able to classify the groups with an accuracy of 73% in the training phase and 89% in the subsequent validation (success rate HV: 90%; EM: 88%). The mean global accuracy within the training and validating samples were 69% (63–78%) and 84% (82–89%). Conclusions: This machine-learning neural network classifier based on visual GBOs provides an accurate and costefficient tool for objective migraine diagnosis. Further training and validation studies with new cohorts are warranted [less ▲]

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See detailBrentano, la théorie des catégories et la définition de la substance
Boccaccini, Federico ULg

in Etudes Philosophiques (2016)

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See detailInvestigation on the use of foamed plastic waste as natural aggregates replacement in lightweight mortar
Coppola, Bartolomeo ULg; Courard, Luc ULg; Michel, Frédéric et al

in Composites : Part B, Engineering (2016), 99

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See detailConsumer acceptance of insect-based alternative meat products in Western countries
Caparros Megido, Rudy ULg; Gierts, Chloé; Blecker, Christophe ULg et al

in Food Quality & Preference (2016)

During the past few years, entomophagy has been increasing in significance. As insects are generally high in protein, they are principally considered as meat substitutes. Nevertheless, in Western ... [more ▼]

During the past few years, entomophagy has been increasing in significance. As insects are generally high in protein, they are principally considered as meat substitutes. Nevertheless, in Western countries, meat substitute consumption is actually very low, principally due to food neophobia and poor sensory qualities in comparison with meat. In insect particular case, food neophobia is clearly high. To reduce insect food neophobia, previous studies suggest to insert invisible insect in food preparation and/or to associate them with known flavors. In this study, a survey on entomophagy perception and hedonic tests were realized to assess the level of sensory-liking of hybrid insect-based burgers (beef, lentils, mealworms and beef, mealworms and lentils). Participants’ overall liking of the four burgers differed between genders and was influenced by burger appearance and taste. Women clearly preferred beef burger appearance, whereas men preferred the appearance of beef and insect-based burgers. Concerning insect-based burger taste, participants (men and women) rated it intermediately, between that of the beef and lentil burger, with a preference for the mealworm and beef burger. Results also showed that people with previous entomophagy experience was limited but that they gave globally higher ratings to all preparations. In conclusion, insect tasting sessions are important to decrease food neophobia, as they encourage people to “take the first step” and become acquainted with entomophagy. Nevertheless, insect integration into Western food culture will involve a transitional phase with minced or powdered insects incorporated into ready-to-eat preparations, as people are not ready to add insects to their diets in “whole form.” [less ▲]

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See detailShort term impact of selective logging on a western lowland gorilla population
Haurez, Barbara ULg; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Forest Ecology & Management (2016), 364

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services ... [more ▼]

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services through animal-mediated seed dispersal. However, there is no clear understanding of the impacts of logging on wildlife or of the extent to which seed dispersal is preserved in logged forests. Given its tendency for nesting in light gaps, the western lowland gorilla is likely to provide directed-dispersal services to a wide range of tree species. Production forests preserved from poaching have been reported to harbor high densities of gorillas, but the monitoring of gorilla populations subjected to logging is poorly documented. This study investigated gorilla density and nesting behavior after timber exploitation in a logging concession in southeast Gabon. Nest count censuses were performed on line transects, before and after the second felling cycle. Gorilla density dropped from 1.5 (116.7 nests km 2, 95% CI = 83.4–163.5) to 1.0 (64.9 nests km 2, % CI = 32.6–129.5) weaned gorilla km 2 4–6 months after logging, then rose to 2.6 (176.3 nests km 2, 95% CI = 113.5–274.1) gorillas km 2 9–11 months after logging. A consistent preference for nesting in open canopy terra firma forest was observed during all censuses. This study demonstrates the short-term resilience of the western lowland gorilla to selective timber harvesting, and argues that they offer a continued contribution to directed-dispersal services within months after logging. Although a long-term monitoring of gorillas in a logged forest should be undertaken, the role of this species in logged forest recovery is thought to be important. The preservation of gorilla should receive particular consideration by forest managers. [less ▲]

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See detailRevue de Fiscalité Régionale et Locale 2016-2
Bourgeois, Marc ULg

in Revue de Fiscalité Régionale et Locale (2016), 2

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See detailExtending abdominal aortic aneurysm detection to older age groups: preliminary results from the Liege screening programme.
MAKRYGIANNIS, Georgios ULg; Labalue, Philippe; Erpicum, Marie ULg et al

in Annals of Vascular Surgery (2016)

BACKGROUND: There is evident benefit in terms of reduced aneurysm related mortality from screening programmes of abdominal aortic aneurysm (AAA) in men aged 65 and more. Recent studies in UK and Sweden ... [more ▼]

BACKGROUND: There is evident benefit in terms of reduced aneurysm related mortality from screening programmes of abdominal aortic aneurysm (AAA) in men aged 65 and more. Recent studies in UK and Sweden have shown a decline of the prevalence of AAA in the general population. Current screening policies (e.g. men aged 65-74 years) however do not account for ageing and increased life expectancy of western populations. This study investigated AAA detection by extending the target population to older age groups (75-85 years). METHODS: AAA screening was conducted in the County of Chaudfontaine (Liege, Belgium) on the population of elderly (N=3,054). The participation rate was 36%. The 1,101 participants (722 men aged 65-85 and 379 women aged 74-85 years) were examined by ultrasound (US) scan. AAA was defined as an infrarenal aortic outer-outer diameter of at least 3 cm. Demographics, clinical parameters and risk factors were also recorded. AAA prevalence was estimated and patients with and without AAA were compared by logistic regression. RESULTS: The overall AAA prevalence was 3.6% (n=40). In female participants, AAA prevalence was low (1.3%). In men, it amounted 2.7% in the 65-74 age group but rose to 7.3% in the age-extended group (75-85 years). Further in addition to age, height, current smoking, history of coronary artery disease, hypercholesterolemia, peripheral artery disease of the lower limbs and varicose veins were significantly associated with the presence of AAA. CONCLUSION: These preliminary findings, based on a representative sample of the elderly population of the Liege region, support the idea that current AAA screening policies should be updated to cover an increasingly ageing population. The presence of varicose veins as a potential risk factor for AAA should also be considered during screening. [less ▲]

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See detailAbelian bordered factors and periodicity
Charlier, Emilie ULg; Harju, Tero; Puzynina, Svetlana et al

in European Journal of Combinatorics (2016), 51

A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only ... [more ▼]

A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only if it contains only finitely many unbordered factors. We are interested in abelian and weak abelian analogues of this result; namely, we investigate the following question(s): Let w be an infinite word such that all sufficiently long factors are (weakly) abelian bordered; is w (weakly) abelian periodic? In the process we answer a question of Avgustinovich et al. concerning the abelian critical factorization theorem. [less ▲]

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See detailThe transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.
Rambout, Xavier ULg; Detiffe, Cecile; Bruyr, Jonathan et al

in Nature Structural & Molecular Biology (2016)

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical ... [more ▼]

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical transcription factors whose previously described functions are confined to the control of mRNA synthesis. Here, we report that ERG also regulates gene expression by affecting mRNA stability and identify the molecular mechanisms underlying this function in human cells. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. Transcriptome-wide mRNA stability analysis revealed that ERG controls the degradation of a subset of mRNAs highly connected to Aurora signaling, whose decay during S phase is necessary for mitotic progression. Our data indicate that control of gene expression by mammalian transcription factors may follow a more complex scheme than previously anticipated, integrating mRNA synthesis and degradation. [less ▲]

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See detailEACVI appropriateness criteria for the use of cardiovascular imaging in heart failure derived from European National Imaging Societies voting.
Garbi, Madalina; Edvardsen, Thor; Bax, Jeroen et al

in European heart journal cardiovascular Imaging (2016)

This paper presents the first European appropriateness criteria for the use of cardiovascular imaging in heart failure, derived from voting of the European National Imaging Societies representatives. The ... [more ▼]

This paper presents the first European appropriateness criteria for the use of cardiovascular imaging in heart failure, derived from voting of the European National Imaging Societies representatives. The paper describes the development process and discusses the results. [less ▲]

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See detailA single amino acid substitution toggles chloride dependence of the alpha-amylase paralog Amyrel in Drosophila melanogaster and Drosophila virilis species
Claisse, G.; Feller, Georges ULg; Bonneau, M. et al

in Insect Biochemistry and Molecular Biology (2016), 75

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See detailTransversus abdominis plane block or intravenous lignocaine in open prostate surgery: a randomized controlled trial.
Maquoi, I.; Joris, J. L.; Dresse, C. et al

in Acta Anaesthesiologica Scandinavica (2016), 60(10), 1453-1460

BACKGROUND AND OBJECTIVES: Transversus abdominis plane block (TAP) and intravenous lignocaine are two analgesic techniques frequently used after abdominal surgery. We hypothesized that these two ... [more ▼]

BACKGROUND AND OBJECTIVES: Transversus abdominis plane block (TAP) and intravenous lignocaine are two analgesic techniques frequently used after abdominal surgery. We hypothesized that these two techniques improve post-operative analgesia after open prostate surgery and sought to compare their efficacy on immediate post-operative outcome after open prostate surgery. METHODS: After ethics committee approval, 101 patients were enrolled in this prospective study and randomly allocated to receive bilateral ultrasound-guided TAP (n = 34), intravenous lignocaine (n = 33) or placebo (n = 34). In addition, intravenous paracetamol was given every 6 h. The primary endpoint was the cumulative opioid consumption during the first 48 post-operative hours (median[IQR]). Secondary endpoints included pain scores at rest and upon coughing, need for rescue tramadol, incidence of post-operative nausea and vomiting (PONV), recovery of bowel function and incidence of bladder catheter-related discomfort. RESULTS: Cumulative piritramide consumption after 48 h was 28 [23] mg in the control group, 21 [29] mg in the TAP group and 21 [31] mg in the lignocaine group (P = 0.065). There was no significant difference in post-operative pain scores between groups. The proportions of patients requiring rescue tramadol, experiencing PONV or bladder catheter-related discomfort were similar in each group. Recovery of bowel function was also similar in the three groups. CONCLUSIONS: Our study suggests that TAP block and intravenous lignocaine do not improve the post-operative analgesia provided by systematic administration of paracetamol after open prostatectomy. [less ▲]

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See detailProcedural learning, consolidation, and transfer of a new skill in Developmental Coordination Disorder
Lejeune, Caroline ULg; Wansard, Murielle ULg; Geurten, Marie ULg et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016), 22(2), 143-154

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill ... [more ▼]

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill automatization (i.e., the stages of fast learning, consolidation, and slow learning). Transfer of the skill to a new situation was also assessed. We tested 34 children aged 6–12 years with and without DCD on a perceptuomotor adaptation task, a form of procedural learning that is thought to involve the cerebellum and the basal ganglia (regions whose impairment has been associated with DCD) but also other brain areas including frontal regions. The results showed similar rates of learning, consolidation, and transfer in DCD and control children. However, the DCD children's performance remained slower than that of controls throughout the procedural task and they reached a lower asymptotic performance level; the difficulties observed at the outset did not diminish with practice. [less ▲]

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See detailOp zoek naar de grenzen van het mechanisme van correctionalisering. Potpourri II en de spreekwoordelijke olifant
Franssen, Vanessa ULg

in Panopticon : Tijdschrift voor Strafrecht, Criminologie en Forensisch Welzijnswerk (2016)

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See detailIntertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces.
Urem, M; Świątek-Połatyńska, M; Rigali, Sébastien ULg et al

in Molecular Microbiology (2016)

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See detailComment j'explore le malaise du nourrisson
Zambelli, Laura ULg; Battisti, Oreste ULg

in Revue Médicale de Liège (2016), 71

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See detailReady for Change!
Nchimi Longang, Alain ULg

in Journal of the Belgian Society of Radiology (2016)

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See detailApparent changes of the Ordovician-Mississippian plant diversity
Cascales-Miñana, Borja ULg

in Review of Palaeobotany and Palynology (2016)

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See detailComparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratio.
Versluis, J.; In 't Hout, F. E. M.; Devillier, R. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2016)

Post-remission treatment (PRT) in patients with cytogenetically normal (CN) acute myeloid leukemia (AML) in first complete remission (CR1) is debated. We studied 521 patients with CN-AML in CR1, for whom ... [more ▼]

Post-remission treatment (PRT) in patients with cytogenetically normal (CN) acute myeloid leukemia (AML) in first complete remission (CR1) is debated. We studied 521 patients with CN-AML in CR1, for whom mutational status of NPM1 and FLT3-ITD was available, including the FLT3-ITD allelic ratio. PRT consisted of reduced intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (alloHSCT) (n=68), myeloablative conditioning (MAC) alloHSCT (n=137), autologous hematopoietic stem cell transplantation (autoHSCT) (n=168) or chemotherapy (n=148). Favorable overall survival (OS) was found for patients with mutated NPM1 without FLT3-ITD (71+/-4%). Outcome in patients with a high FLT3-ITD allelic ratio appeared to be very poor with OS and relapse-free survival (RFS) of 23+/-8% and 12+/-6%, respectively. Patients with wild-type NPM1 without FLT3-ITD or with a low allelic burden of FLT3-ITD were considered as intermediate-risk group because of similar OS and RFS at 5 years, in which PRT by RIC alloHSCT resulted in better OS and RFS as compared with chemotherapy (hazard ratio (HR) 0.56, P=0.022 and HR 0.50, P=0.004, respectively) or autoHSCT (HR 0.60, P=0.046 and HR 0.60, P=0.043, respectively). The lowest cumulative incidence of relapse (23+/-4%) was observed following MAC alloHSCT. These results suggest that alloHSCT may be preferred in patients with molecularly intermediate-risk CN-AML, while the choice of conditioning type may be personalized according to risk for non-relapse mortality.Leukemia advance online publication, 15 July 2016; doi:10.1038/leu.2016.183. [less ▲]

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See detailON THE USE OF HIGH-THROUGHPUT SEQUENCING FOR THE STUDY OF CYANOBACTERIAL DIVERSITY IN ANTARCTIC AQUATIC MATS 1
Stelmach Pessi, Igor ULg; De Carvalho Maalouf, Pedro; Laughinghouse, Haywood Dail et al

in Journal of Phycology (2016), 52

The study of Antarctic cyanobacterial diversity has been mostly limited to morphological identification and traditional molecular techniques. High-throughput sequencing (HTS) allows a much better ... [more ▼]

The study of Antarctic cyanobacterial diversity has been mostly limited to morphological identification and traditional molecular techniques. High-throughput sequencing (HTS) allows a much better understanding of microbial distribution in the environment, but its application is hampered by several methodological and analytical challenges. In this work we explored the use of HTS as a tool for the study of cyanobacterial diversity in Antarctic aquatic mats. Our results highlight the importance of using artificial communities to validate the parameters of the bioinformatics procedure used to analyse natural communities, since pipeline-dependent biases had a strong effect on the observed community structures. Analysis of microbial mats from five Antarctic lakes and an aquatic biofilm from the Sub-Antarctic showed that HTS is a valuable tool for the assessment of cyanobacterial diversity. The majority of the OTUs retrieved were related to filamentous taxa such as Leptolyngbya and Phormidium, which are common genera in Antarctic lacustrine microbial mats. However, other phylotypes related to different taxa such as Geitlerinema, Pseudanabaena, Synechococcus and Chamaesiphon, Calothrix and Coleodesmium were also found. Results revealed a much higher diversity than what had been reported using traditional methods and also highlighted remarkable differences between the cyanobacterial communities of the studied lakes. The aquatic biofilm from the Sub-Antarctic had a distinct cyanobacterial community in comparison to the studied Antarctic lakes, which, in turn, displayed a salinity-dependent community-structure at the phylotype level. [less ▲]

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See detailA Text Structure Indicator and two Topological Methods: New Ways for Studying Latin Historic Narratives
Longrée, Dominique ULg; Mellet, Sylvie

in DSH: Digital Scholarship in the Humanities (2016)

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See detailStakeholders’ perceptions, attitudes and practices towards risk prevention in the food chain
Lupo, C; Wilmart, O; Van Huffel, X et al

in Food Control (2016), 66

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See detailThe Changing Landscape of Smoldering Multiple Myeloma: A European Perspective
CAERS, Jo ULg; de Larrea, Carlos; Leleu, Xavier et al

in Oncologist (2016), 21

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating ... [more ▼]

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with highrisk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention, although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group asMM, and thus will require optimalMMtreatment, based on biomarkers that identify patients with a.80% risk of progression. The number of these redefined patients is small (∼10%), but important to unravel, because their risk of progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-highrisk SMM are now considered as MMand may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation needs to be undertaken. For the greater majority ofSMMpatients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. [less ▲]

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See detailPositron Emission Tomography: Basic Principles, New Applications, and Studies Under Anesthesia
KIRSCH, Murielle ULg; Wannez, Sarah ULg; Thibaut, Aurore ULg et al

in International Anesthesiology Clinics (2016)

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See detailMyoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer
Fahmy, Karim ULg; Gonzalez, Arnaud ULg; Arafa, Mohammad et al

in International Journal of Cancer = Journal International du Cancer (2016), 138

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas ... [more ▼]

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis. However, the function of myoferlin in pancreas adenocarcinoma has not been reported. In other cell types, myoferlin is involved in several key plasma membrane processes such as fusion, repair, endocytosis and tyrosine kinase receptor activity. In this study, we showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. In addition to be smaller, the tumors formed by the myoferlin-silenced cells showed a marked absence of functional blood vessels. We further demonstrated that this effect was due, at least in part, to an inhibition of VEGFA secretion by BxPC-3 myoferlin-silenced cells. Using immunofluorescence and electron microscopy, we linked the decreased VEGFA secretion to an impairment of VEGFA exocytosis. The clinical relevance of our results was further strengthened by a significant correlation between myoferlin expression in a series of human pancreatic malignant lesions and their angiogenic status evaluated by the determination of the blood vessel density. [less ▲]

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See detailUn empirisme de style husserlien
Seron, Denis ULg

in Revue Philosophique de Louvain (2016), 114(1), 49-71

L’objectif poursuivi dans cette étude est de mettre en avant un empirisme « de style husserlien » et d’en indiquer les avantages sur l’empirisme ordinaire. D’abord, partant d’une définition classique due ... [more ▼]

L’objectif poursuivi dans cette étude est de mettre en avant un empirisme « de style husserlien » et d’en indiquer les avantages sur l’empirisme ordinaire. D’abord, partant d’une définition classique due à Chisholm et Sellars, l’auteur énumère les principales thèses de l’empirisme au sens ordinaire et en discute quelques difficultés intrinsèques à la lumière des critiques de Chisholm, Sellars, Goodman et d’autres. Il tente ensuite de montrer que, par son « principe des principes », Husserl a proposé une forme originale d’empirisme, plausiblement moins problématique que ses variantes classiques. L’argument est que l’empirisme de style husserlien échappe aux difficultés énumérées par sa double dimension réflexive et normative. [less ▲]

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See detailLiver Transplantation for Hepatic Trauma: A Study From the European Liver Transplant Registry.
Krawczyk, Marek; Grat, Michal; Adam, Rene et al

in Transplantation (2016), 100(11), 2372-2381

BACKGROUND: Liver transplantation is the most extreme form of surgical management of patients with hepatic trauma, with very limited literature data supporting its use. The aim of this study was to assess ... [more ▼]

BACKGROUND: Liver transplantation is the most extreme form of surgical management of patients with hepatic trauma, with very limited literature data supporting its use. The aim of this study was to assess the results of liver transplantation for hepatic trauma. METHODS: This retrospective analysis based on European Liver Transplant Registry comprised data of 73 recipients of liver transplantation for hepatic trauma performed in 37 centers in the period between 1987 and 2013. Mortality and graft loss rates at 90 days were set as primary and secondary outcome measures, respectively. RESULTS: Mortality and graft loss rates at 90 days were 42.5% and 46.6%, respectively. Regarding general variables, cross-clamping without extracorporeal veno-venous bypass was the only independent risk factor for both mortality (P = 0.031) and graft loss (P = 0.034). Regarding more detailed factors, grade of liver trauma exceeding IV increased the risk of mortality (P = 0.005) and graft loss (P = 0.018). Moreover, a tendency above the level of significance was observed for the negative impact of injury severity score (ISS) on mortality (P = 0.071). The optimal cut-off for ISS was 33, with sensitivity of 60.0%, specificity of 80.0%, positive predictive value of 75.0%, and negative predictive value of 66.7%. CONCLUSIONS: Liver transplantation seems to be justified in selected patients with otherwise fatal severe liver injuries, particularly in whom cross-clamping without extracorporeal bypass can be omitted. The ISS cutoff less than 33 may be useful in the selection process. [less ▲]

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See detailA surgical approach in the treatment of preputial gland abscesses in mice
Bertrand, Henri ULg; Thomas, Aurélie ULg; Ellen, Yvette et al

in BMC Veterinary Research (2016), 12(16),

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See detailCovariance-constrained difference inversion of time-lapse electrical resistivity tomography data
Hermans, Thomas ULg; Kemna, Andreas; Nguyen, Frédéric ULg

in Geophysics (2016), 81(5), 311-322

Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active ... [more ▼]

Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active processes in shallow subsurface reservoirs. Time-lapse inversion schemes have been developed to refine inversion results, but they mostly still rely on a spatial regularization procedure based on the standard smoothness constraint. In this paper, we propose to apply a covariance-based regularization operator in the time-lapse ERT inverse problem. We first illustrate the method for surface and cross-hole ERT with two synthetic cases and compare the results with the smoothness-constrained inversion (SCI). The examples show that the covariance–constrained inversions (CCI) better image the anomaly both in terms of shape and amplitude. Although more important in low-sensitivity zones, improvements are observed everywhere in the tomograms. Those synthetic examples also show that an error made in the range or in the type of the variogram model has a limited impact on the resulting image, which still remains better than SCI. The method is then applied to cross-borehole ERT field data from a heat tracing experiment, where the comparison with direct measurements shows a strong improvement of the breakthrough curves retrieved from ERT. The proposed method could be extended to the time dimension which would allow the use of CCI in 4D inversion schemes. [less ▲]

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See detailThe place of viscoelastic testing in clinical practice.
Hans, Grégory ULg; Besser, Martin W.

in British Journal of Haematology (2016), 173(1), 37-48

Hellmut Hartert was the first person to exploit the viscoelastic properties of clotting blood to measure blood coagulation in 1948. Since then, the technology has improved, allowing these analyses to be ... [more ▼]

Hellmut Hartert was the first person to exploit the viscoelastic properties of clotting blood to measure blood coagulation in 1948. Since then, the technology has improved, allowing these analyses to be performed as point-of-care tests with immediately-available results. The addition of several activators and inhibitors to the original assay creates a panel of tests able to quantify the different aspects of blood clotting that can rival conventional laboratory assays. However, although much progress has been made, the standardization and validation of these tests still need improvement. Viscoelastic analyses of blood coagulation are mainly used to guide haemostatic therapy in bleeding patients and have proven superior to standard clotting tests in some circumstances. There is potential to extend their use to other areas, such as drug monitoring, and diagnosis and management of congenital bleeding disorders. The forthcoming cartridge-based assays are expected to improve the reliability and usability of viscoelastic assays of blood coagulation but high quality clinical trials remain urgently needed to determine their exact place, benefit and cost effectiveness. [less ▲]

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See detailAdding mucins to an in vitro batch fermentation model of the large intestine induces changes in microbial population isolated from porcine feces depending on the substrate
Tran, Thi Hanh Tham ULg; Boudry, Christelle ULg; Everaert, Nadia ULg et al

in FEMS Microbiology Ecology (2016), 92(2), 13

Adding mucus to in vitro fermentation models of the large intestine showed that some genera, namely lactobacilli, are dependent on host-microbiota interactions and that they rely on mucosa layers to ... [more ▼]

Adding mucus to in vitro fermentation models of the large intestine showed that some genera, namely lactobacilli, are dependent on host-microbiota interactions and that they rely on mucosa layers to increase their activity. This study investigates whether this dependence on mucus is substrate-dependent and to which extend other genera are impacted by the presence of mucus. Inulin and cellulose were fermented in vitro by a fecal inoculum from pig in the presence or not of mucin-beads in order to compare fermentation patterns and bacterial communities. Mucins increased final gas production with inulin and shifted short-chain fatty acids molar ratios (P<0.001). QPCR analyses revealed that Lactobacillus spp. and Bifidobacterium spp. decreased with mucins, but Bacteroides spp. increased when inulin was fermented. A more in-depth community analysis indicated that the mucins increased Proteobacteria (0.55 vs. 0.25 %, P=0.013), Verrucomicrobia (5.25 vs. 0.03 %, P=0.032), Ruminococcaceae, Bacteroidaceae, and Akkermansia spp.. Proteobacteria (5.67 vs. 0.55 %, P<0.001) and Lachnospiraceae (33 vs. 10.4 %) were promoted in the mucuscompared to the broth, while Ruminococcaceae decreased. The introduction of mucins affected many microbial genera and fermentation patterns, but from PCA results, the impact of mucus was independent from the fermentation substrate. [less ▲]

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See detailWoody plant cover estimation in drylands from Earth Observation based seasonal metrics
Brandt, Martin; Hiernaux, Pierre; Tagesson, Torbern et al

in Remote Sensing of Environment (2016), 172

From in situ measured woody cover we develop a phenology driven model to estimate the canopy cover of woody species in the Sahelian drylands at 1 km scale. The model estimates the total canopy cover of ... [more ▼]

From in situ measured woody cover we develop a phenology driven model to estimate the canopy cover of woody species in the Sahelian drylands at 1 km scale. The model estimates the total canopy cover of all woody phanerophytes and the concept is based on the significant difference in phenophases of dryland trees, shrubs and bushes as compared to that of the herbaceous plants. Whereas annual herbaceous plants are only green during the rainy season and senescence occurs shortly after flowering towards the last rains, most woody plants remain photosynthetically active over large parts of the year. We use Moderate Resolution Imaging Spectroradiometer (MODIS) and Satellite pour l'Observation de la Terre (SPOT) — VEGETATION (VGT) Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) time series and test 10 metrics representing the annual FAPAR dynamics for their ability to reproduce in situ woody cover at 43 sites (163 observations between 1993 and 2013) in the Sahel. Both multi-year field data and satellite metrics are averaged to produce a steady map. Multiple regression models using the integral of FAPAR from the onset of the dry season to the onset of the rainy season, the start date of the growing season and the rate of decrease of the FAPAR curve achieve a cross validated r2/RMSE (in % woody cover) of 0.73/3.0 (MODIS) and 0.70/3.2 (VGT). The extrapolation to Sahel scale shows agreement between VGT and MODIS at an almost nine times higher woody cover than in the global tree cover product MOD44B which only captures trees of a certain minimum size. The derived woody cover map of the Sahel is made publicly available and represents an improvement of existing products and a contribution for future studies of drylands quantifying carbon stocks, climate change assessment, as well as parametrization of vegetation dynamic models. [less ▲]

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See detailApoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy.
Vidlickova, Ivana; Dequiedt, Franck ULg; Jelenska, Lenka et al

in BMC Cancer (2016), 16(1), 239

BACKGROUND: Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion ... [more ▼]

BACKGROUND: Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer prognosis. We previously showed that the CA IX ECD release is mediated by disintegrin and metalloproteinase ADAM17. Here we investigated the CA IX ECD shedding in tumor cells undergoing apoptosis in response to cytotoxic drugs, including cycloheximide and doxorubicin. METHODS: Presence of cell surface CA IX was correlated to the extent of apoptosis by flow cytometry in cell lines with natural or ectopic CA IX expression. CA IX ECD level was assessed by ELISA using CA IX-specific monoclonal antibodies. Effect of recombinant CA IX ECD on the activation of molecular pathways was evaluated using the cell-based dual-luciferase reporter assay. RESULTS: We found a significantly lower occurrence of apoptosis in the CA IX-positive cell subpopulation than in the CA IX-negative one. We also demonstrated that the cell-surface CA IX level dropped during the death progress due to an increased ECD shedding, which required a functional ADAM17. Inhibitors of metalloproteinases reduced CA IX ECD shedding, but not apoptosis. The CA IX ECD release induced by cytotoxic drugs was connected to elevated expression of CA IX in the surviving fraction of cells. Moreover, an externally added recombinant CA IX ECD activated a pathway driven by the Nanog transcription factor implicated in epithelial-mesenchymal transition and stemness. CONCLUSIONS: These findings imply that the increased level of the circulating CA IX ECD might be useful as an indicator of an effective antitumor chemotherapy. Conversely, elevated CA IX ECD might generate unwanted effects through autocrine/paracrine signaling potentially contributing to resistance and tumor progression. [less ▲]

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See detailSocial Enterprise and Social Entrepreneurship Conceptions: What is at Stake beyond Discourses?
Defourny, Jacques ULg; Nyssens, Marthe

in BBE Newsletter für Engagement und Partizipation in Deutschland (2016), 2016(5), 1-7

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See detailCOMMENT JE TRAITE ... une colique néphrétique.
Lavergne, O.; Bonnet, Quentin; Thomas, Alexandre et al

in Revue Médicale de Liège (2016), 71(5), 220-6

Renal colic (RC) represents nearly 2% of emergency department admissions. RC is defined by the occurrence of back pain which may radiate towards the abdomen and external genitals. In adults, the ... [more ▼]

Renal colic (RC) represents nearly 2% of emergency department admissions. RC is defined by the occurrence of back pain which may radiate towards the abdomen and external genitals. In adults, the obstruction is caused by a urinary stone in 80% of cases. The 20 % of non-stone related RCs are due either to an intrinsic obstruction (pyeloureteral junction stenosis, ureteral tumor, ...) or an extrinsic compression (pelvic tumor, lymphadenopathy ...). In over 90% of cases, an RC does not require hospitalization and is treated with medication. In contrast, complicated renal colic (CRC) requires hospitalization with specialized care. Obstructive pyelonephritis (OPN) is a form of CRC and the diagnosis should be considered in a clinical presentation of "renal colic" with acute pyelonephritis. This is a true emergency requiring surgical drainage of the upper urinary tract upstream of the obstacle, as well as antibiotic therapy. It must be kept in mind that some clinical presentations may be atypical, especially in the elderly, which can delay the diagnosis and, thus, the management. The gold standard for diagnosis is CT urography. [less ▲]

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See detailLes soins de santé primaires, plus que des soins de première ligne
Crismer, André ULg; Belche, Jean ULg; van der Vennet, Jean

in Santé Publique : Revue Multidisciplinaire pour la Recherche et l'Action (2016)

Primary health care are often spoken about , but they are rarely defined. This article explores this concept and founds two different understandings of primary health care, both issued from Alma Ata ... [more ▼]

Primary health care are often spoken about , but they are rarely defined. This article explores this concept and founds two different understandings of primary health care, both issued from Alma Ata Declaration. As long as the expression « primary health care » may correspond to two types of contents, or a level of care, or a global approach of the health system, it will be useful to clarify it, when using it. [less ▲]

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See detailEffect of Traveler’s Nationality on Daily Travel Time Expenditure Using Zero-Inflated Negative Binomial Regression Models: Results from Belgian National Household Travel Survey
Eftekhar, Hamed ULg; Creemers, Lieve; Cools, Mario ULg

in Transportation Research Record: Journal of the Transportation Research Board (2016), 2565

In this study, data stemming from the 2010 Belgian National Household Travel Survey were used to assess the effect of a traveler’s nationality on daily travel time expenditure. Negative binomial (zero ... [more ▼]

In this study, data stemming from the 2010 Belgian National Household Travel Survey were used to assess the effect of a traveler’s nationality on daily travel time expenditure. Negative binomial (zero-inflated) models were estimated to isolate the effect of nationality after other contributing factors such as sociodemographics, residential characteristics, transport options, and temporal characteristics were controlled for. The results indicate that even if one controls for a series of other influencing factors, nationality plays a significant role in differences in travel time expenditure. This finding is especially relevant in the development of policy packages that are targeted at social inequalities. From a methodological perspective, methodological options—two weighting schemes and two bootstrap solutions—were presented to provide sufficient support for the conclusions. To generalize the results in further studies, an oversampling of travelers of different nationalities is strongly recommended. Future research should focus more on the underlying psychological constructs of why ethnic and cultural differences persist even if one accounts for other determinants. [less ▲]

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See detailRelationship between grey matter integrity and executive abilities in aging
Manard, Marine ULg; Bahri, Mohamed Ali ULg; Salmon, Eric ULg et al

in Brain Research (2016), 1642

This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young ... [more ▼]

This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18 to 30 years old) and 43 seniors (60 to 75 years old) were included. A general executive score was derived from a large battery of neuropsychological tests assessing three major aspects of executive functioning (inhibition, updating and shifting). Age-related grey matter changes were investigated by comparing young and older adults using voxel-based morphometry and voxel-based cortical thickness methods. A widespread difference in grey matter volume was found across many brain regions, whereas cortical thinning was mainly restricted to central areas. Multivariate analyses showed age-related changes in relatively similar brain regions to the respective univariate analyses but appeared more limited. Finally, in the older adult sample, a significant relationship between global executive performance and decreased grey matter volume in anterior (i.e. frontal, insular and cingulate cortex) but also some posterior brain areas (i.e. temporal and parietal cortices) as well as subcortical structures was observed. Results of this study highlight the distribution of age-related effects on grey matter volume and show that cortical atrophy does not appear primarily in “frontal” brain regions. From a cognitive viewpoint, age-related executive functioning seems to be related to grey matter volume but not to cortical thickness. Therefore, our results also highlight the influence of methodological aspects (from preprocessing to statistical analysis) on the pattern of results, which could explain the lack of consensus in literature. [less ▲]

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See detailZooarchaeological study of an Upper Palaeolithic site with mammoth remains, Pushkari Ieexcavation VII (Chernigov oblast, Ukraine)
Demay, Laëtitia ULg; Péan, Stéphane; Belyaeva, Valentina I. et al

in Quaternary International (2016)

The Pushkari archaeological complex is one of the few sites which shows human occupations related to the first part of the Upper Pleniglacial. Pushkari I furnished rich archaeological material. Study of ... [more ▼]

The Pushkari archaeological complex is one of the few sites which shows human occupations related to the first part of the Upper Pleniglacial. Pushkari I furnished rich archaeological material. Study of the lithic industry identified a facies of Gravettian with epigravettian features, called Pushkarian. In order to figure out acquisition and treatment modalities of large mammals, and to test the hypothesis of the use of woolly mammoth as a source of food and building material, we conducted a zooarchaeological study of the faunal remains from excavation VII of Pushkari I. The faunal spectrum is made of Mammuthus primigenius, the predominant species, Equus sp., R. tarandus, Canis lupus and Vulpes vulpes/Alopex lagopus. Taphonomic study suggests that some bone remains of mammoth lay in open-air for a long time before they were buried while bones of carnivores and other bones of mammoth were quickly buried. All the assemblage was affected by acid sandy deposits. Phenomena of freeze-thaw action were observed, but the archaeological layer was little disturbed. Mammoths came regularly on the promontory. The skeletal preservation shows that they died there. The mortality profile with a majority of adults combined with a palethnographic interpretation suggests that they were slaughtered and butchered by human groups. Tusks were stored. The spatial distribution indicates a campsite, which corresponds to recurrent short-termed occupations on the promontory by human groups. This site is a strategic place to collect flint to make weapons, to find dry mammoth bones, and to hunt and butcher mammoths. This study provides new data to understand the particular status of the woolly mammoth for the Upper Pleniglacial human groups in the Russo-Ukrainian plain. [less ▲]

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See detailThe radial artery for coronary artery bypass grafting: a second revival?
Sousa Uva, Miguel; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(1), 210-1

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See detailEvaluation of anode (electro)catalytic materials for the direct borohydride fuel cell: methods and benchmarks
Olu, Pierre-Yves ULg; Job, Nathalie ULg; Chatenet, Marian

in Journal of Power Sources (2016), 327

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See detailImpact of cyclonic and anticyclonic activity on Greenland ice sheet surface mass balance variation during 1980–2013
Chen, L.; Fettweis, Xavier ULg; Knudsen, E. et al

in International Journal of Climatology (2016)

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective ... [more ▼]

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective, extratropical cyclones and anticyclones are the major systems influencing Greenland weather conditions. Seasonal cyclonic and anticyclonic activities have been quantified for the area of 50°–90°N, 80°W–10°E during 1980–2013. Based on a singular value decomposition (SVD) analysis, we investigated the role of synoptic scale cyclonic and anticyclonic activities in determining snow accumulation (SA) and surface air temperature (SAT). Thus, the SA-driven and melt-driven SMB variability has been determined. SA-related synoptic patterns identified from the leading and the second SVD modes explain up to 80% of the inter-annual SMB variance, especially in southern and northwestern Greenland, where we found the largest and second largest amount of annual SA. SAT-related patterns account for up to 80% of the inter-annual SMB variation along the west and northwest coast of Greenland, where significant surface mass loss has been observed over the last decades. It should be noted that the negative phase of the SA-related pattern derived from the first SVD mode in June-July-August and the positive phase of the SAT-related (anti)cyclonic patterns have occurred more frequently since 2005, meaning that the phase change of these patterns has made a major contribution to the accelerated GrIS surface ice loss during recent years. [less ▲]

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See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (deuxième partie)
Léonard, Laura ULg; Caprasse, Olivier; Dieux, Xavier et al

in Revue Critique de Jurisprudence Belge [= RCJB] (2016), (2),

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See detailBacteria may contribute to distant species recognition in ant–aphid mutualistic relationships
Fischer, Christophe ULg; Detrain, Claire; Thonart, Philippe ULg et al

in Insect Science (2016)

Mutualistic interactions between ant and aphid species have been the subject of considerable historical and contemporary investigations, the primary benefits being cleaning and protection for the aphids ... [more ▼]

Mutualistic interactions between ant and aphid species have been the subject of considerable historical and contemporary investigations, the primary benefits being cleaning and protection for the aphids and carbohydrate-rich honeydew for the ants. Questions remained, however, as to the volatile semiochemical factor influencing this relationship. A recent study highlighted the role of bacterial honeydew volatile compounds in ant attraction. Here, ant’s ability to distantly discriminate two aphid species was investigated based on bacterial honeydew semiochemicals emissions using a two-way olfactometer. Both the mutualistic black bean aphid (Aphis fabae L.) and the non-myrmecophilous pea aphid (Acyrthosiphon pisum Harris) were found to be attractive for the black garden ant (Lasius niger L.). The level of attraction was similar in both assays (control versus one of the aphid species). However, when given a choice between these two aphid species, ants showed a significant preference for Aphis fabae. Honeydew volatiles, mostly from bacterial origins, are known to be a key element in ant attraction. Using the same olfactometry protocol, the relative attractiveness of volatiles emitted by honeydews collected from each aphid species and by bacteria isolated from each honeydew was in investigated. Again, ants significantly preferred volatiles released by Aphis fabae honeydew and bacteria. This information suggests that microbial honeydew volatiles enable ants to distantly discriminate aphid species. These results emphasize the importance of investigating the presence and potential effects of microbes in insect symbioses. [less ▲]

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See detailLiquid chromatography separation of the chiral prodrug eslicarbazepine acetate and its main metabolites in polar organic mode. Application to their analysis after in vitro metabolism.
Servais, Anne-Catherine ULg; Janicot, Bertrand; Takam, Arnold et al

in Journal of Chromatography. A (2016), 1467

A LC method using a chiral stationary phase (CSP) with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector in polar organic mode (POM) was developed for the separation of the ... [more ▼]

A LC method using a chiral stationary phase (CSP) with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector in polar organic mode (POM) was developed for the separation of the biopharmaceutic classification system (BCS) class II chiral prodrug eslicarbazepine acetate (ESL) and its main metabolites, namely eslicarbazepine, its optical antipode, (R)-licarbazepine, and the achiral oxcarbazepine (OXC). The percentage of methanol (MeOH) in the mobile phase containing acetonitrile (ACN) as the main solvent was found to significantly influence analyte retention and resolution. A reversal of elution order of OXC and (R)-licarbazepine was observed, depending on the MeOH percentage in the mobile phase. The optimized mobile phase consisted of ACN/MeOH/acetic acid/diethylamine (95/5/0.2/0.07; v/v/v/v). The potential of this chemo- and enantioselective LC method combined with solid-phase extraction (SPE) was then evaluated for in vitro metabolism studies using ESL as a model case. Only eslicarbazepine could be detected after incubation of ESL in human liver microsome systems. [less ▲]

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See detailCooperation-Competition Relationship between Small Traditional Handicraft Enterprises in the Proximity Context: Case Study in the Periphery of Hanoi – Vietnam
Nguyen, Thi Thu Hien ULg; Nguyen Thi Trang Nhung, ULg; Lebailly, Philippe ULg

in International Journal of Business and Social Science (2016), 7(8/August 2016), 121-127

Small traditional handicraft enterprises contribute a significantly to develop society, economics, and culture of the local through creating jobs for rural labors, increasing local budget, as well as ... [more ▼]

Small traditional handicraft enterprises contribute a significantly to develop society, economics, and culture of the local through creating jobs for rural labors, increasing local budget, as well as maintaining and developing the traditional cultural values. There are interactionsamong the firms due to near locations. The aim of this paper is to describe characteristics of the cooperation- competition among small traditional handicraft enterprises located adjacent to Hanoi capital city. Moreover, the paper also points out the relationship between cooperation- proximity, and competition-proximity. It finds that the cooperation-competition relationship always exists among the enterprises and in the proximity condition. This paper gives recommendations on the strengthening cooperation between firms and improving local industry based on the cooperation – competition relationships.The methodology of research applied isa qualitative analysis, an exploratory analysis in the grounded theory. [less ▲]

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See detailInvectif et logique conflictuelle dans le champ du rap français
Saint-Amand, Denis ULg

in Etudes de Lettres (2016), 3

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See detailNavigating towards decoupled aquaponic systems: A system dynamics design approach
Goddek, Simon; Espinal, Carlos; Delaide, Boris et al

in Water (2016), 8(303),

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See detailBox search for the data mining of the key parameters of an industrial process
Louveaux, Quentin ULg; Mathei, Axel; Mathieu, Sébastien ULg

in Intelligent Data Analysis (2016), 20(6),

To increase their competitiveness, many industrial companies monitor their production process, collecting large amount of measurements. This paper describes a technique using this data to improve the ... [more ▼]

To increase their competitiveness, many industrial companies monitor their production process, collecting large amount of measurements. This paper describes a technique using this data to improve the performance of a monitored process. In particular we wish to find a set of rules, i.e. intervals on a reduced number of parameters, for which an output value is maximized. The model-free optimization problem to solve is to find a box, restricted on a limited amount of dimensions, with the maximum mean value of the included points. This article compares a machine learning-based heuristic to the solution computed by a mixed-integer linear program on real-life databases from steel and glass manufacturing. Computational results show that the heuristic obtains comparable solutions to the mixed integer linear approach. However, the exact approach is computationally too expensive to tackle real life databases. Results show that the restriction of five process parameters, on these databases, may improve the quality of the process by 50%. [less ▲]

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See detailMicrofluidic chip with molecular beacons detects miRNAs in Human CSF to reliably characterize CNS-specific disorders
Zadran, S.; Remacle, Françoise ULg; Levine, R. D.

in RNA & Disease (2016), 3

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See detailAn age-calibrated definition of chronic kidney disease: Rationale and benefits.
DELANAYE, Pierre ULg; Glassock, Richard; Pottel, H et al

in Clinical Biochemist. Reviews (2016), 37(1),

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See detailBRYONIA ALBA L. AND ECBALLIUM ELATERIUM (L.) A. RICH. - TWO RELATED SPECIES OF THE CUCURBITACEAE FAMILY WITH IMPORTANT PHARMACEUTICAL POTENTIAL
Ielciu, Irina-Ioana ULg; Frederich, Michel ULg; Tits, Monique ULg et al

in Farmacia (2016), 64(3), 323-332

The importance of the Cucurbitaceae family consists not only in the species that are widely known for various economically important human uses, but also in the species that have proven an important and ... [more ▼]

The importance of the Cucurbitaceae family consists not only in the species that are widely known for various economically important human uses, but also in the species that have proven an important and promising potential concerning their biological activities. Bryonia alba L. and Ecballium elaterium (L.) A. Rich. are two species belonging to this family, that are known since ancient times for their homeopathic or traditional use in the treatment of numerous disorders. There is clear evidence that links between the two species are not only related to family morphological characters, but also to a certain degree to the sexual system and, most importantly, to the active principle content or to potential medicinal uses. All these elements helped to include both species in the same tribe and may result in important reasons for heading future studies towards the elucidation of their complete phytochemical composition and mechanisms of the biological activities. The present study aims to review the existing scientific literature on the two species and to offer sufficient evidence in order to justify a most detailed study of their pharmaceutical potential. [less ▲]

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See detailClassification of riparian forest species and health condition using multi-temporal and hyperspatial imagery from unmanned aerial system
Michez, Adrien ULg; Piégay, Hervé; Lisein, Jonathan ULg et al

in Environmental Monitoring and Assessment (2016), 188(3),

Riparian forests are critically endangered many anthropogenic pressures and natural hazards. The importance of riparian zones has been acknowledged by European Directives, involving multi-scale monitoring ... [more ▼]

Riparian forests are critically endangered many anthropogenic pressures and natural hazards. The importance of riparian zones has been acknowledged by European Directives, involving multi-scale monitoring. The use of this very high resolution and hyperspatial imagery in a multi-temporal approach is an emerging topic. The trend is reinforced by the recent and rapid growth of the use of the unmanned aerial system (UAS), which has prompted the development of innovative methodology. Our study proposes a methodological framework to explore how a set of multi-temporal images acquired during a vegetative period can differentiate some of the deciduous riparian forest species and their health conditions. More specifically, the developed approach intends to identify, through a process of variable selection, which variables derived from UAS imagery and which scale of image analysis are the most relevant to our objectives. The methodological framework is applied to two study sites to describe the riparian forest through two fundamental characteristics: the species composition and the health condition. These characteristics were selected not only because of their use as proxies for the riparian zone ecological integrity but also because of their use for river management. The comparison of various scales of image analysis identified the smallest OBIA objects (ca. 1 m²) as the most relevant scale. Variables derived from spectral information (bands ratio's) were identified as the most appropriate, followed by variables related to the vertical structure of the forest. Classification results show good overall accuracies for the species composition of the riparian forest (five classes, 79.5 and 84.1 % for Site 1 and Site 2). The classification scenario regarding the health condition of the black alders of the Site 1 performed the best (90.6 %). The quality of the classification models developed with a UAS-based, cost-effective, and semi-automatic approach competes successfully with those developed using more expensive imagery, such as multispectral and hyperspectral airborne imagery. The high overall accuracy results obtained by the classification of the diseased alders open the door to applications dedicated to monitoring of the health conditions of riparian forest. Our methodological framework will allow UAS users to manage large imagery metrics datasets derived from those dense time series. [less ▲]

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See detailBovine Staphylococcus aureus: Subtyping, evolution, and zoonotic transfer.
Boss, R.; Cosandey, A.; Luini, M. et al

in Journal of dairy science (2016), 99(1), 515-28

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that ... [more ▼]

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that Staph. aureus isolated from bovine intramammary infections are genetically heterogeneous, with Staph. aureus genotype B (GTB) and GTC being the most prominent genotypes. Furthermore, Staph. aureus GTB was found to be contagious, whereas Staph. aureus GTC and all the remaining genotypes were involved in individual cow disease. In addition to RS-PCR, other methods for subtyping Staph. aureus are known, including spa typing and multilocus sequence typing (MLST). They are based on sequencing the spa and various housekeeping genes, respectively. The aim of the present study was to compare the 3 analytic methods using 456 strains of Staph. aureus isolated from milk of bovine intramammary infections and bulk tanks obtained from 12 European countries. Furthermore, the phylogeny of animal Staph. aureus was inferred and the zoonotic transfer of Staph. aureus between cattle and humans was studied. The analyzed strains could be grouped into 6 genotypic clusters, with CLB, CLC, and CLR being the most prominent ones. Comparing the 3 subtyping methods, RS-PCR showed the highest resolution, followed by spa typing and MLST. We found associations among the methods but in many cases they were unsatisfactory except for CLB and CLC. Cluster CLB was positive for clonal complex (CC)8 in 99% of the cases and typically positive for t2953; it is the cattle-adapted form of CC8. Cluster CLC was always positive for tbl 2645 and typically positive for CC705. For CLR and the remaining subtypes, links among the 3 methods were generally poor. Bovine Staph. aureus is highly clonal and a few clones predominate. Animal Staph. aureus always evolve from human strains, such that every human strain may be the ancestor of a novel animal-adapted strain. The zoonotic transfer of IMI- and milk-associated strains of Staph. aureus between cattle and humans seems to be very limited and different hosts are not considered as a source for mutual, spontaneous infections. Spillover events, however, may happen. [less ▲]

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See detailFacteurs pronostiques du cancer pulmonaire non à petites cellules
GESTER, Fanny; PAULUS, Astrid ULg; SIBILLE, Anne ULg et al

in Revue Médicale de Liège (2016), 71(1), 34-39

Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of ... [more ▼]

Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of a surgical management with curative intent. This paper gives an overview of the main prognostic factors, the two most important of which remain the staging and tumor histology. These also determine the therapeutic strategy. Other factors of poor prognosis might also be useful for clinicians, particularly in their decision to refer patients for adjuvant therapies. Keywords : Non-small cell lung cancer – Prognostic factors – Pulmonary oncology – Surgery [less ▲]

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See detailNetworks of prospective thoughts: the organisational role of emotion and its impact on well-being
Demblon, Julie ULg; D'Argembeau, Arnaud ULg

in Cognition & Emotion (2016), 30

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully ... [more ▼]

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully understood. Here, we investigated the organisational role of emotion by using cues of different valence for eliciting event networks. We found that manipulating the emotional valence of cues influenced the characteristics of events within networks, and that members of a network were more similar to each other on affective components than they were to members of other networks. Furthermore, a substantial proportion of events within networks were part of thematic clusters and cluster membership significantly modulated the impact of represented events on current well-being, in part through an intensification of the emotion felt when thinking about these events. These findings demonstrate that emotion contributes to the organisation of future thoughts in networks that can affect people’s well-being. [less ▲]

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See detailThe terrestrialization process: A palaeobotanical and palynological perspective (2).
Meyer-Berthaud, Brigitte; Servais, Thomas; Vecoli, Marco et al

in Review of Palaeobotany and Palynology (2016)

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See detailQuand l’enfant révèle un abus sexuel : le vécu du couple, ses fonctions et conséquences.
Gallo, Alicia ULg; Wertz, Céline ULg; Blavier, Adelaïde ULg

in Neuropsychiatrie de l'Enfance et de l'Adolescence (2016), 64

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See detailIl n'est jamais trop tard pour apprendre à (bien) lire ... La revue systématique
Beaudart, Charlotte ULg; Rabenda, Véronique ULg; Bruyère, Olivier ULg

in Ortho-Rhumato (2016), 14(6), 37-40

La revue systématique est généralement utilisée pour synthétiser les résultats de plusieurs études traitant d’un même sujet. Son intérêt est donc grand, particulièrement depuis ces dernières années où le ... [more ▼]

La revue systématique est généralement utilisée pour synthétiser les résultats de plusieurs études traitant d’un même sujet. Son intérêt est donc grand, particulièrement depuis ces dernières années où le nombre d’articles scientifiques publiés dans la littérature explose! La revue systématique est considérée comme une étude de haut niveau de preuve scientifique. En effet, elle se retrouve au sommet de la pyramide de l’evidence-based medicine. Elle est donc, lorsqu’elle est de qualité, d’un niveau de preuve supérieur aux études randomisées contrôlées, aux études de cohortes, aux études cas-témoins… [less ▲]

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See detailUse of the potential probiotic strain Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers.
Saint-Cyr, Manuel Jimmy; Haddad, Nabila; Taminiau, Bernard ULg et al

in International Journal of Food Microbiology (2016)

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler ... [more ▼]

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler chicken will lower the risk to consumers. The aim of this project was to evaluate the ability of Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers and to investigate the mechanisms that could be involved. Thirty broilers artificially contaminated with C. jejuni were treated by oral gavage with MRS broth or a bacterial suspension (107CFU) of Lb. salivarius SMXD51 (SMXD51) in MRS broth. At 14 and 35days of age, Campylobacter and Lb. salivarius loads were assessed in cecal contents. The impact of the treatment on the avian gut microbiota at day 35 was also evaluated. At day 14, the comparison between the control and treated groups showed a significant reduction (P<0.05) of 0.82 log. After 35days, a significant reduction (P<0.001) of 2.81 log in Campylobacter loads was observed and 73% of chickens treated with the culture exhibited Campylobacter loads below 7log10CFU/g. Taxonomic analysis revealed that SMXD51 treatment induced significant changes (P<0.05) in a limited number of bacterial genera of the avian gut microbiota and partially limited the impact of Campylobacter on Anaerotruncus sp. decrease and Subdoligranulum sp. increase. Thus, SMXD51 exhibits an anti-Campylobacter activity in vivo and can partially prevent the impact of Campylobacter on the avian gut microbiota. [less ▲]

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See detailDeletion of Murid Herpesvirus 4 ORF63 Affects the Trafficking of Incoming Capsids toward the Nucleus.
Latif, Muhammad Bilal ULg; Machiels, Bénédicte ULg; Xiao, Xue ULg et al

in Journal of virology (2016), 90(5), 2455-72

Gammaherpesviruses are important human and animal pathogens. Despite the fact that they display the classical architecture of herpesviruses, the function of most of their structural proteins is still ... [more ▼]

Gammaherpesviruses are important human and animal pathogens. Despite the fact that they display the classical architecture of herpesviruses, the function of most of their structural proteins is still poorly defined. This is especially true for tegument proteins. Interestingly, a potential role in immune evasion has recently been proposed for the tegument protein encoded by Kaposi's sarcoma-associated herpesvirus open reading frame 63 (ORF63). To gain insight about the roles of ORF63 in the life cycle of a gammaherpesvirus, we generated null mutations in the ORF63 gene of murid herpesvirus 4 (MuHV-4). We showed that disruption of ORF63 was associated with a severe MuHV-4 growth deficit both in vitro and in vivo. The latter deficit was mainly associated with a defect of replication in the lung but did not affect the establishment of latency in the spleen. From a functional point of view, inhibition of caspase-1 or the inflammasome did not restore the growth of the ORF63-deficient mutant, suggesting that the observed deficit was not associated with the immune evasion mechanism identified previously. Moreover, this growth deficit was also not associated with a defect in virion egress from the infected cells. In contrast, it appeared that MuHV-4 ORF63-deficient mutants failed to address most of their capsids to the nucleus during entry into the host cell, suggesting that ORF63 plays a role in capsid movement. In the future, ORF63 could therefore be considered a target to block gammaherpesvirus infection at a very early stage of the infection. IMPORTANCE: The important diseases caused by gammaherpesviruses in human and animal populations justify a better understanding of their life cycle. In particular, the role of most of their tegument proteins is still largely unknown. In this study, we used murid herpesvirus 4, a gammaherpesvirus infecting mice, to decipher the role of the protein encoded by the viral ORF63 gene. We showed that the absence of this protein is associated with a severe growth deficit both in vitro and in vivo that was mainly due to impaired migration of viral capsids toward the nucleus during entry. Together, our results provide new insights about the life cycle of gammaherpesviruses and could allow the development of new antiviral strategies aimed at blocking gammaherpesvirus infection at the very early stages. [less ▲]

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See detailLocal ensemble assimilation scheme with global constraints and conservation
Barth, Alexander ULg; Yan, Yajing ULg; Alvera Azcarate, Aida ULg et al

in Ocean Dynamics (2016), 66

Ensemble assimilation schemes applied in their original, global formulation respect linear conservation properties if the ensemble perturbations are set up accordingly. For realistic ocean systems, only a ... [more ▼]

Ensemble assimilation schemes applied in their original, global formulation respect linear conservation properties if the ensemble perturbations are set up accordingly. For realistic ocean systems, only a relatively small number of ensemble members can be calculated. A localization of the ensemble increment is therefore necessary to filter out spurious long-range correlations. The conservation of the global properties will be lost if the assimilation is performed locally, since the conservation requires a coupling between all model grid points which is removed by the localization. The distribution of ocean observations is often highly inhomogeneous. Systematic errors of the observed parts of the ocean state can lead to spurious adjustment of the non-observed parts via data assimilation and thus to a spurious increase or decrease in long-term simulations of global properties which should be conserved. In this paper, we propose a local assimilation scheme (with different variants and assumptions) which can satisfy global conservation properties. The proposed scheme can also be used for non-local observation operators. Different variants of the proposed scheme are tested in an idealized model and compared to the traditional covariance localization with an ad-hoc step enforcing conservation. It is shown that the inclusion of the conservation property reduces the total RMS error and that the presented stochastic and deterministic schemes avoiding error space rotation provide better results than the traditional covariance localization. [less ▲]

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See detailOn the Habitability of Desert Varnish: a Combined Study by Micro-Raman Spectroscopy, X-Ray Diffraction and Methylated Pyrolysis-Gas Chromatography-Mass Spectrometry
Malherbe, Cédric ULg; Hutchinson, Ian; Ingley, Richard et al

in Astrobiology (2016)

In 2020, the ESA ExoMars and NASA Mars 2020 missions will be launched to Mars, searching for evidence of past and present life. In preparation for these missions, terrestrial analogue samples of rock ... [more ▼]

In 2020, the ESA ExoMars and NASA Mars 2020 missions will be launched to Mars, searching for evidence of past and present life. In preparation for these missions, terrestrial analogue samples of rock formations on Mars are studied in detail in order to optimize the scientific information that the analytical instrumentation will return. Desert varnishes are thin mineral coatings found on rocks in arid and semi-arid environments on Earth that are recognized as analogue samples. During the formation of desert varnishes (which takes many hundreds of years) organic matter is incorporated and microorganisms may also play an active role in the formation process. During this study, four complementary analytical techniques proposed for Mars missions (X-rays diffraction, Raman spectroscopy, elemental analysis and pyrolysis-gas chromatography-mass spectrometry) were used to interrogate samples of desert varnish and to describe their capacity to sustain life under extreme scenario. For the first time, both the geochemistry and the organic compounds associated with desert varnish are described using an identical set of samples. XRD and Raman spectroscopy measurements were used to non-destructively interrogate the mineralogy of the samples. In addition, the use of Raman spectroscopy instruments enabled the detection of β-carotene, a highly Raman active biomarker. The content and the nature of the organic material in the samples was further investigated using elemental analysis and methylated Py-GC-MS and a bacterial origin was determined to be likely. In the context of planetary exploration, we describe the habitable nature of desert varnish based on the bio-geochemical composition of the samples. Possible interference of the geological substrate on the detectability of pyrolysis products is also suggested. [less ▲]

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See detailA simple LC-MS method for the determination of iohexol and iothalamate in serum, using ioversol as an internal standard.
Nyssen, Laurent ULg; DELANAYE, Pierre ULg; Le Goff, Caroline ULg et al

in Clinica Chimica Acta (2016), 463

BACKGROUND: Chronic kidney disease (CKD) is diagnosed and explored through the determination of the glomerular filtration rate (GFR). Our goal was to develop a simple LC-MS method for the determination in ... [more ▼]

BACKGROUND: Chronic kidney disease (CKD) is diagnosed and explored through the determination of the glomerular filtration rate (GFR). Our goal was to develop a simple LC-MS method for the determination in serum of 2 popular GFR markers, contrast agents iohexol and iothalamate, for routine use and comparison studies between the two markers. A similar contrast agent, ioversol, was used as an internal standard and the method underwent a rigorous validation protocol based on beta-expectation tolerance intervals. METHODS: We adapted the HPLC-UV method from Cavalier et al. to our LC-MS system. Data treatment for the validation was performed using Multiquant 3.0 (Sciex, Framingham, MA, USA) and e.noval 3.0 software (Arlenda, Liege, Belgium). RESULTS: According to the validation results our method will give accurate and reliable results for concentrations ranging from 6.8 to 250mug/ml for iohexol and 6.15mug/ml to 250mug/ml for iothalamate. In our practice these intervals are sufficient to determine both compounds in most patient samples. Samples with higher detected concentrations can always be diluted into range. CONCLUSION: With its internal standard and extensive validation, our method is now ready for routine and clinical research use. [less ▲]

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See detailCan breeder reproductive status, performance and egg quality be enhanced by supplementation and transition of n-3 fatty acids?
Delezie, E.; Koppenol, A.; Buyse, J. et al

in Journal of Animal Physiology and Animal Nutrition (2016)

Summary: The aim of this experiment was to investigate the effect of n-3 fatty acid (FA) supplemented diets on breeder performance, productivity and egg quality. Breeders (n = 480) were fed the ... [more ▼]

Summary: The aim of this experiment was to investigate the effect of n-3 fatty acid (FA) supplemented diets on breeder performance, productivity and egg quality. Breeders (n = 480) were fed the supplemented diet from 18 weeks onwards; the inclusion level of n-3 FA was increased from 1.5% to 3.0% from 34 weeks of age onwards until 48 weeks of age. Ross-308 broiler breeders (n = 480) were fed one of four different diets: a basal diet rich in n-6 FA (control diet) or one of three diets rich in n-3 FA. For the n-3 FA diets, eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) were fed to the broiler breeders at different ratios formulated to obtain EPA/DHA ratios of 1/1, 1/2 or 2/1. Differences in performance, reproduction and egg quality parameters due to n-3 supplementation were noted more for the 1.5% followed by the 3.0% fed broilers than their 1.5% supplemented counterparts. Egg weight (p < 0.001) and egg mass (p = 0.003) were significantly lower and feed conversion (p = 0.008) significantly higher for the n-3 FA (at 3.0% inclusion level) fed broilers compared to the control group. For the EPA- and DHA-fed breeders, a higher proportional abdominal fat percentage (p = 0.025) and proportional albumen weight (%) (p = 0.041) were found respectively. Dietary treatments did not affect reproduction. It can be concluded that the results of the present experiment indicate no significant differences between treatments at 1.5% inclusion levels. However, increasing this level to 3.0% is not recommended due to the rather negative effects on the measured parameters. It should be further investigated whether these adverse effects were obtained due to (i) the higher supplementation level, (ii) combining a supplementation level of 1.5% with 3% or (iii) the duration of supplementation. © 2016 Blackwell Verlag GmbH. [less ▲]

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See detailEvolution of land use-change modeling: routes of different schools of knowledge
Azadi, Hossein; Barati, Ali Akbar; Rafiaani, Parisa et al

in Landscape and Ecological Engineering (2016), (12 (December 2016)), 1-14

Although much has been published on land use-change models (LUCMs), no study has comprehensively dealt with the evolution of land use models based on schools of knowledge. The primary objective of this ... [more ▼]

Although much has been published on land use-change models (LUCMs), no study has comprehensively dealt with the evolution of land use models based on schools of knowledge. The primary objective of this paper is an explanation of the progress and growth of LUCMs concerning their main ontological, epistemological, and methodological origins. Five main paradigms, i.e., positivism, post-positivism, constructivism, participatory, and pragmatism approaches, are discussed in order to assess the current orientations of LUCMs. Given the complexities of LUCM components, the study concludes that one paradigm cannot adequately address all methodological aspects. Accordingly, it is necessary to combine quantitative and qualitative paradigms to create mixed-method approaches within a systemic framework. Such systemic approaches could shape the most probable future generations of LUCMs, which would be able to cope with the complexity of various subsystems, including biophysical and socioeconomic ones. [less ▲]

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See detailÉvolution des séries silicoclastiques miocènes en Tunisie centrale : Cas de la coupe de Khechem El Artsouma
Belghithi, Hanen ULg; Boulvain, Frédéric ULg; Chokri, Yaich et al

in Carnets de Géologie = Notebooks on Geology (2016), 16(23), 557-568

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See detailProjecting the self into the future in individuals with schizophrenia: a preliminary cross-sectional study.
Raffard, Stephane; Bortolon, Catherine; D'Argembeau, Arnaud ULg et al

in Memory (2016), 24(6), 826-837

The ability to project oneself into the future contributes to development and maintenance of a coherent sense of identity. If recent research has revealed that schizophrenia is associated with ... [more ▼]

The ability to project oneself into the future contributes to development and maintenance of a coherent sense of identity. If recent research has revealed that schizophrenia is associated with difficulties envisioning the future, little is known about patients' future self-representations. In this study, 27 participants with schizophrenia and 26 healthy controls were asked to simulate mental representations of plausible and highly significant future events (self-defining future projections, SDFPs) that they anticipate to happen in their personal future. Main results showed that schizophrenia patients had difficulties in reflecting on the broader meaning and implications of imagined future events. In addition, and contrary to our hypothesis, a large majority of SDFPs in schizophrenia patients were positive events, including achievements, relationship, and leisure contents. Interestingly, patients and controls did not differ on the perceived probability that these events will occur in the future. Our results suggest that schizophrenia patients have an exaggerated positive perception of their future selves. Together, these findings lend support to the idea that past and future self-defining representations have both similar and distinct characteristics in schizophrenia. [less ▲]

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See detailIs non-host pollen suitable for generalist bumblebees?
Vanderplanck, Maryse ULg; Decleves, S.; Roger, N. et al

in Insect Science (2016)

Current evidence suggests that pollen is both chemically and structurally protected. Despite increasing interest in studying bee-flower networks, the constraints for bee development related to pollen ... [more ▼]

Current evidence suggests that pollen is both chemically and structurally protected. Despite increasing interest in studying bee-flower networks, the constraints for bee development related to pollen nutritional content, toxicity and digestibility as well as their role in the shaping of bee-flower interactions have been poorly studied. In this study we combined bioassays of the generalist bee Bombus terrestris on pollen of Cirsium, Trifolium, Salix, and Cistus genera with an assessment of nutritional content, toxicity, and digestibility of pollen. Microcolonies showed significant differences in their development, non-host pollen of Cirsium being the most unfavorable. This pollen was characterized by the presence of quite rare δ7-sterols and a low digestibility. Cirsium consumption seemed increase syrup collection, which is probably related to a detoxification mixing behavior. These results strongly suggest that pollen traits may act as drivers of plant selection by bees and partly explain why Asteraceae pollen is rare in bee generalist diet. © 2016 Institute of Zoology, Chinese Academy of Sciences. [less ▲]

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