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See detailCOMMENT EXPLORER LES SYMPTOMES NEGATIFS DE LA PSYCHOSE CHEZ L'ENFANT: UNE SEMIOLOGIE DIMENSIONNELLE
SCHOLL, Jean-Marc ULg

in Acta Psychiatrica Belgica (2015), 116(3), 15-21

Despite its high frequency, psychotic syndrome in childhood is little understood and is often diagnosed only after several years of development, and this during a time when the child’s psychosocial future ... [more ▼]

Despite its high frequency, psychotic syndrome in childhood is little understood and is often diagnosed only after several years of development, and this during a time when the child’s psychosocial future is at stake. Negative symptoms are systematically present at the prodromal phase and are the most stable thereafter. It is therefore essential to furnish clinicians with precise semiological markers to recognize it. This paper presents a dimensional semiology of the negative symptoms for use in anamnesis and in clinical observation of the child. Is also gives a guide to the interviewing process. [less ▲]

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See detailNumerical modelling of transient cyclic vertical loading of suction caissons in sand
Cerfontaine, Benjamin ULg; Collin, Frédéric ULg; Charlier, Robert ULg

in Geotechnique (2015), 65(12),

This paper presents numerical investigations of the monotonic and cyclic behaviours of suction caissons upon vertical transient loading. Both drained and partially drained conditions are investigated ... [more ▼]

This paper presents numerical investigations of the monotonic and cyclic behaviours of suction caissons upon vertical transient loading. Both drained and partially drained conditions are investigated. Monotonic compression and traction simulations are carried out to qualitatively compare results with the literature and validate the model. They highlight the different modes of reaction of the caisson to both compression and traction loading. A sensitivity analysis points out the strong influence of some parameters on the resistance of the caisson but also on the failure mechanism. The transient behaviour of the caisson upon different kinds of cyclic load signals is analysed. Results reproduce the settlement and pore water pressure accumulations observed during experiments. The influence of the key design parameters on the settlement accumulation is also assessed. Finally a cyclic diagram is proposed to describe the evolution of the final settlement upon different magnitudes of loading. [less ▲]

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See detailSéance de renforcement musculaire utilisant des objets du quotidien
Dubru, Gilles ULg; Cloes, Marc ULg

in Revue de l'Education Physique (2015), 55(1), 43-56

Les professeurs d’éducation physique proposent régulièrement des leçons portant sur le renforcement musculaire faisant partie des compétences à acquérir par les élèves (domaine de la condition physique ... [more ▼]

Les professeurs d’éducation physique proposent régulièrement des leçons portant sur le renforcement musculaire faisant partie des compétences à acquérir par les élèves (domaine de la condition physique). En revanche, il n'est pas nécessairement fréquent que ces séances visent à expliquer aux élèves comment ils peuvent exploiter ce qu'ils apprennent à l'école lorsqu'ils sont chez eux. Cet article illustre une approche susceptible de combler ce manque. [less ▲]

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See detailAdult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury
Neirinckx, Virginie ULg; Agirman, Gulistan ULg; Coste, Cécile ULg et al

in Stem Cell Research and Therapy (2015), 6(211),

Introduction: Stem cells from adult tissues were considered for a long time as promising tools for regenerative therapy of neurological diseases, including spinal cord injuries (SCI). Indeed, mesenchymal ... [more ▼]

Introduction: Stem cells from adult tissues were considered for a long time as promising tools for regenerative therapy of neurological diseases, including spinal cord injuries (SCI). Indeed, mesenchymal (MSCs) and neural crest stem cells (NCSCs) together constitute the bone marrow stromal stem cells (BMSCs) that were used as therapeutic options in various models of experimental SCI. However, as clinical approaches remained disappointing, we thought that reducing BMSC heterogeneity should be a potential way to improve treatment efficiency and reproducibility. Methods: We investigated the impact of pure populations of MSCs and NCSCs isolated from adult bone marrow in a mouse model of spinal cord injury. We then analyzed the secretome of both MSCs and NCSCs, and its effect on macrophage migration in vitro. Results: We first observed that both cell types induced motor recovery in mice, and modified the inflammatory reaction in the lesion site. We also demonstrated that NCSCs but especially MSCs were able to secrete chemokines and attract macrophages in vitro. Finally, it appears that MSC injection in the spinal cord enhance early inflammatory events in the blood and spinal cord of SCI mice. Conclusions: Altogether, our results suggest that both cell types have beneficial effects in experimental SCI, and that further investigation should be dedicated to the regulation of the inflammatory reaction following SCI, in the context of stem cell-based therapy but also in the early-phase clinical management of SCI patients. [less ▲]

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See detailIncapacité de travail prolongée. Revue des facteurs de risque professionnels et des stratégies d'intervention
Somville, Pierre ULg; Mairiaux, Philippe ULg

in Archives des Maladies Professionnelles et de l'Environnement (2015), 76(5), 458-467

Purpose of the study In the context of the general population aging and the increasing cost of work disability, public authorities pay special attention to the employability of workers with health ... [more ▼]

Purpose of the study In the context of the general population aging and the increasing cost of work disability, public authorities pay special attention to the employability of workers with health problems. In order to consider strategies for reducing the duration of disability and promoting the return-to-work, the Belgian Federal Public Service Work and Employment wished to have an update of the available scientific evidence on this topic. Methods This literature review is based on articles published in English between 2001 and 2011 and extracted from the MEDLINE database. The review first part deals with long term incapacity risk factors while the second one describes evidence as regards prevention measures and intervention strategies. Results Some risk factors significantly associated with long term disability have been identified: being employed in heavy jobs, fear-avoidance reactions and psychosocial occupational factors such as job dissatisfaction, lack of work control, insufficient support, poor relationships with colleagues, but also the worker own perception of his ability to return to work. Early detection of these perceived barriers to return to work is needed. With regard to intervention strategies, the review, limited to low back pain associated work absences, supports the interest of ergonomic changes in the working environment and the importance of participative interventions. The communication between the return to work actors (i.e. clinical physicians, occupational physicians, employers, insurers and the worker himself) is a key factor in the success of the intervention. Finally, in heavier workload occupations, promoting a systematic access to a transitory light duty position appears to be an interesting guideline. [less ▲]

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See detailAmphibians forgo aquatic life in response to alien fish introduction
Winandy, Laurane ULg; Darnet, Elodie; Denoël, Mathieu ULg

in Animal Behaviour (2015), 109

Species with complex life cycles are good models to understand trade-offs between life in hostile and favourable habitats. Newts remain in breeding wetlands for a long period and are strongly affected by ... [more ▼]

Species with complex life cycles are good models to understand trade-offs between life in hostile and favourable habitats. Newts remain in breeding wetlands for a long period and are strongly affected by fish introduction; however, mechanisms of the exclusion observed in the field are still not well known. In particular, whether newts skip breeding and leave water for land in response to fish introduction and how aquatic shelter may influence their choice remain open questions. To investigate these questions, we experimentally studied the use of aquatic and terrestrial habitats during the breeding season of palmate newts, Lissotriton helveticus, in the presence and absence of goldfish, Carassius auratus. We determined the consequences of habitat choice on newt fitness by assessing sexual activity and number of eggs. There was a strong, significant avoidance of the aquatic environment in the presence of fish, particularly when no aquatic shelter was available. This escape from the water had an impact on reproduction: newts decreased their sexual activity and laid fewer eggs. The availability of shelters favoured coexistence but did not prevent a large proportion of the newts from leaving water and skipping reproduction. This study shows how the presence of fish and the absence of aquatic shelters can lead to newts forgoing aquatic life, thus improving our understanding of the mechanisms behind the coexistence and exclusion patterns found in the wild. More broadly, these data contribute to explaining aquatic versus terrestrial life in favourable and unfavourable environments. [less ▲]

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See detailA Parallel Processing Approach to Dynamic Simulations of Combined Transmission and Distribution Systems
Aristidou, Petros ULg; Van Cutsem, Thierry ULg

in International Journal of Electrical Power & Energy Systems (2015), 72

Simulating a power system with both transmission and distribution networks modeled in detail is a huge computational challenge. In this paper, a Schur-complement-based domain decomposition algorithm is ... [more ▼]

Simulating a power system with both transmission and distribution networks modeled in detail is a huge computational challenge. In this paper, a Schur-complement-based domain decomposition algorithm is proposed to provide accurate, detailed dynamic simulations of such systems. The simulation procedure is accelerated with the use of parallel programming techniques, taking advantage of the parallelization opportunities inherent to domain decomposition algorithms. The proposed algorithm is general, portable and scalable on inexpensive, shared-memory, multi-core machines. A large-scale test system is used for its performance evaluation. [less ▲]

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See detailHistoires sur Able Archer
Kluge, Alexander; Leyh, Valérie ULg

in Cahiers d'Etudes Germaniques (2015), 69

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See detailLégitimité des recommandations sur la viscosupplémentation
Henrotin, Yves ULg

in Rhumatos (2015), 12(111), 280

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See detailCharacteristics and typology of sheep herding systems in the suburban area of Ouagadougou (Burkina Faso)
Tindano, Kisito ULg; Moula, Nassim ULg; Traoré, A. et al

in Archiv für Tierzucht = Archives Animal Breeding (2015), 58

Strong increase in demand for animal products could benefit local producers in developing countries. This development opportunity particularly concerns suburban livestock. In Burkina Faso, the suburban ... [more ▼]

Strong increase in demand for animal products could benefit local producers in developing countries. This development opportunity particularly concerns suburban livestock. In Burkina Faso, the suburban area of Ouagadougou is a place for the setting up of an increasing number of breeders. Due to its importance in religious traditions, spurring its consumption in whole West Africa, mutton is a major part of this suburban production. In order to characterize sheep farming in the suburban zone of Ouagadougou, in terms of motives, practices, and economic performance, and to better understand the dynamic at play in the sheep sector, a survey has been conducted among 80 sheep farmers around Ouagadougou. The results show that suburban sheep keeping is a highly dual sector. Nearly half (42.5 %) of farms may be described as traditional livestock, while 50% are evolving towards intensification. These two groups essentially differ in terms of animal genetic and feeding management, farm infrastructure, and farmer education level. Economically, the whole sample tends to indicate a lack of profitability of the activity in terms of monetary income. Several factors contributing to this situation are pinpointed, namely feed and animal health constraints, flock and production management, and the market conditions. [less ▲]

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See detailRadiative origin of neutrino masses
Aristizabal Sierra, Diego ULg

in Acta Physica Polonica B (2015), 46

Mechanisms for Majorana neutrino mass generation can be classified according to the level at which the Weinberg operator is generated. The different possibilities can be sorted in “canonical” tree-level ... [more ▼]

Mechanisms for Majorana neutrino mass generation can be classified according to the level at which the Weinberg operator is generated. The different possibilities can be sorted in “canonical” tree-level and loop-induced realizations, the latter being motivated by their potential experimental testability. Here, we discuss the one- and two-loop cases, paying special attention to systematic classification schemes, whose aim is that of constructing a full picture for neutrino mass generation [less ▲]

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See detailDerivation and Application of Sensitivities to Assess Transient Voltage Sags caused by Rotor Swings
Weckesser, Tilman; Johannsson, Hjortur; Ostergaard, Jacob et al

in International Journal of Electrical Power & Energy Systems (2015), 72

The paper introduces an approach to investigate voltage sags, which are caused by large generator rotor swings following a transient disturbance. Therefore, the method exploits sensitivities derived from ... [more ▼]

The paper introduces an approach to investigate voltage sags, which are caused by large generator rotor swings following a transient disturbance. Therefore, the method exploits sensitivities derived from the algebraic network equations. These provide information on the impact of a generator on the voltage magnitude at a load bus and the e ffect of load variation on the generator's power injection. It is shown that these sensitivities give valuable information to identify critical generator-load pairs and locations for applying preventive control measures. [less ▲]

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See detailFE modeling of the cooling and tempering steps of bimetallic rolling mill rolls
Neira Torres, Ingrid; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in International Journal of Material Forming (2015)

Numerical simulations enable the analysis of the stress and strain histories of bimetallic rolling mill rolls. The history of rolling mill rolls is simulated by thermo-mechanical metallurgical finite ... [more ▼]

Numerical simulations enable the analysis of the stress and strain histories of bimetallic rolling mill rolls. The history of rolling mill rolls is simulated by thermo-mechanical metallurgical finite element code while considering two steps: post-casting cooling and subsequent tempering heat treatment. The model requires a notably large set of material parameters. For different phases and temperatures, Young modulus, yield limit and tangent plastic modulus are determined through compression tests. Rupture stresses and strains are obtained by tensile tests. Thermo-physical parameters are measured by such experimental methods as dilatometry, DSC (Differential Scanning Calorimetry) and Laser Flash methods. Such parameters as the transformation plasticity coefiicients for the ferrite, pearlite and martensite phases are identified through an inverse method. From the simulation results, the profile of the stresses evolution at different critical times is presented. An analysis of the potential damage is proposed by comparing the predicted axial stress \vith rupture stresses. The perspective of the Ghosh and McClintock damage criteria is also investigated. [less ▲]

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See detailREGISTRE BELGE ET CENTRES DE RÉFÉRENCE POUR LES MALADIES TROPHOBLASTIQUES GESTATIONNELLES
DELCOMINETTE, Sarah ULg; TIMMERMANS, Marie ULg; DELBECQUE, Katty ULg et al

in Revue Médicale de Liège (2015), 70(11), 550-556

Gestational trophoblastic diseases include placental pathologies comprising fertilization abnormalities (hydatidiform moles) and malignant lesions (choriocarcinoma, placental site trophoblastic tumor and ... [more ▼]

Gestational trophoblastic diseases include placental pathologies comprising fertilization abnormalities (hydatidiform moles) and malignant lesions (choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor). Due to their low incidence and heterogeneity, their diagnosis, management and treatment are not always optimal. Following the example of other European countries, a national registration system with two reference centers has been set up to guide physicians and patients and to propose individualized management. The centers offer their expertise through a systematic centralised pathology review by a panel of experts. HCG values are plotted in regression curves. In case of gestational trophoblastic neoplasia, an imaging work-up is proposed, from which the FIGO score and stage are derived and will guide the choice of treatment. Belgian centers offer a multidisciplinary approach, in partnership with the referent physician. More information for practitioners and patients is available on a web site: www.mole-chorio-bgog.eu, which also harbours a forum of discussion. [less ▲]

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See detailL’ETUDE CLINIQUE DU MOIS EMPA-REG OUTCOME : L’empagliflozine réduit la mortalité chez le patient diabétique de type 2 à haut risque cardiovasculaire
SCHEEN, André ULg

in Revue Médicale de Liège (2015), 70

Summary : EMPA-REG OUTCOME is an international, prospective, placebo-controlled clinical trial investigating the cardiovascular outcomes of empagliflozin, an inhibitor of sodium-glucose cotransporters ... [more ▼]

Summary : EMPA-REG OUTCOME is an international, prospective, placebo-controlled clinical trial investigating the cardiovascular outcomes of empagliflozin, an inhibitor of sodium-glucose cotransporters type 2 (SGLT2), in patients with type 2 diabetes mellitus and known cardiovascular disease. The trial succeeded in reaching the primary objective of non-inferiority and, in addition, showed, after a median follow up of 3.1 years, a superiority of empagliflozin (10 or 25 mg/day) versus placebo as regards the primary composite cardiovascular endpoint (hasard ratio or HR = 0.86; 95% CI 0.74-0.99; P = 0.04), hospitalisations for heart failure (- 35 %), cardiovascular mortality (- 38 %) and all-cause mortality (- 32 %, each p< 0.001). The reduction in mortality appeared early (< 6 months) and concerned all subgroups, without any obvious heterogeneity. This reduction in mortality does not seem to be fully explained by the concomitant slight reductions in HbA1c, body weight, waist circumference, blood pressure and serum uric acid levels in the empagliflozin groups versus the placebo group. Finally, the tolerance and safety profile of empagliflozin was good, with only a moderate increase in benign mycotic genital infections, a well-known adverse event with SGLT2 inhibitors. The remarkable effects of empagliflozin in the EMPA-REG OUTCOME trial, especially on mortality, should modify the management of patients with type 2 diabetes and a high cardiovascular risk in a near future. [less ▲]

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See detailThe N-terminal region of CHD4 is essential for activity and contains a HMG-box-like-domain that can bind poly(ADP-ribose).
Silva, Ana; Ryan, Daniel; Galanty, Y et al

in Journal of Biological Chemistry (2015)

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See detailSymptômes neurologiques du bord latéral du pied et de la cheville
WANG, François-Charles ULg

in Médecine et Chirurgie du Pied = Foot Medicine and Surgery (2015), 31

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See detailFinite element modelling of composite structures under crushing load
Chiu, Louis N.S.; Falzon, Brian G.; Boman, Romain ULg et al

in Composite Structures (2015), 131

This paper details the theory and implementation of a composite damage model, addressing damage within a ply (intralaminar) and delamination (interlaminar), developed for the simulation of the crushing of ... [more ▼]

This paper details the theory and implementation of a composite damage model, addressing damage within a ply (intralaminar) and delamination (interlaminar), developed for the simulation of the crushing of laminated composite structures. It includes a more accurate determination of the characteristic length to achieve mesh objectivity in capturing intralaminar damage consisting of matrix cracking and fibre failure, a load-history dependent material response, an isotropic hardening nonlinear matrix response, as well as a more physically-based interactive matrix damage mechanism. The developed damage model requires a set of material parameters obtained from a combination of standard and non-standard material characterisation tests. The fidelity of the model mitigates the need to manipulate, or “calibrate”, the input data to achieve good agreement with experimental results. This intralaminar damage model was implemented as a VUMAT subroutine, and used in conjunction with an existing interlaminar damage model, in Abaqus/Explicit. This approach was validated through the simulation of the crushing of a cross-ply composite tube with a tulip-shaped trigger, loaded in uniaxial compression. Despite the complexity of the chosen geometry, excellent correlation was achieved with experimental results. [less ▲]

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See detailOpportunités pour la valorisation des végétaux riches en anthocyanes comme sources de colorants alimentaires (synthèse bibliographique)
Beye, Cheikh ULg; Tounkara, Lat Souk; Seck, Mamadou Amadou et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(4), 392-401

Introduction. Très répandues dans le règne végétal, les anthocyanes sont le sujet d’un grand nombre d’études qui abordent en général les aspects concernant leur instabilité vis-à-vis des conditions dans ... [more ▼]

Introduction. Très répandues dans le règne végétal, les anthocyanes sont le sujet d’un grand nombre d’études qui abordent en général les aspects concernant leur instabilité vis-à-vis des conditions dans lesquelles elles sont employées ou l’effet bénéfique de leur consommation sur la santé. Littérature. Ces aspects sont particulièrement importants lorsqu’on envisage de les extraire en vue de leur utilisation comme colorant alimentaire naturel. Dans cette revue bibliographique, les propriétés des anthocyanes susceptibles d’être altérées lors de leur transformation ont été étudiées. Par la suite, un état des lieux sur les méthodes de fabrication de colorants à base d’anthocyanes a été fait afin de dégager des perspectives pour l’exploitation des matières végétales qui en contiennent de grandes quantités. Conclusions. Les fruits et légumes utilisables pour la fabrication de colorants alimentaires sont nombreux et variés. Les différences au niveau du contenu ont une influence sur la stabilité de la couleur des extraits, mais les progrès récents en matière de formulation ouvrent des perspectives pour la valorisation des végétaux riches en anthocyanes. [less ▲]

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See detailL'image du mois : Le processus thrombotique sous la loupe (microscopie intravitale)
Oury, Cécile ULg; Hego, Alexandre ULg; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2015), 70(11), 537-539

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See detailThe genome of a tortoise herpesvirus (testudinid herpesvirus 3) has a novel structure and contains a large region that is not required for replication in vitro or virulence in vivo.
Gandar, Frederic ULg; Wilkie, Gavin S.; Gatherer, Derek et al

in Journal of Virology (2015), 89(22), 11438-11456

Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on ... [more ▼]

Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on characterizing its properties, in order to enable the development of prophylactic methods. We have sequenced the genomes of the two most studied TeHV-3 strains (1976 and 4295). TeHV-3 strain 1976 has a novel genome structure and is most closely related to a turtle herpesvirus, thus supporting its classification into genus Scutavirus, subfamily Alphaherpesvirinae, family Herpesviridae. The sequence of strain 1976 also revealed viral counterparts of cellular interleukin-10 and semaphorin, which have not been described previously in members of subfamily Alphaherpesvirinae. TeHV-3 strain 4295 is a mixture of three forms (m1, m2, and M), in which, in comparison to strain 1976, the genomes exhibit large, partially overlapping deletions of 12.5 to 22.4 kb. Viral subclones representing these forms were isolated by limiting dilution assays, and each replicated in cell culture comparably to strain 1976. With the goal of testing the potential of the three forms as attenuated vaccine candidates, strain 4295 was inoculated intranasally into Hermann's tortoises (Testudo hermanni). All inoculated subjects died, and PCR analyses demonstrated the ability of the m2 and M forms to spread and invade the brain. In contrast, the m1 form was detected in none of the organs tested, suggesting its potential as the basis of an attenuated vaccine candidate. Our findings represent a major step toward characterizing TeHV-3 and developing prophylactic methods against it. [less ▲]

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See detailTentative insight into the multiplicity of the persistent dust maker WR 106 from X-ray observations
De Becker, Michaël ULg

in New Astronomy (2015), 41

This paper presents the results of the analysis of the very first dedicated X-ray observation with XMM-Newton of WR 106. This carbon-rich WC9d Wolf–Rayet star belongs to the category of persistent dust ... [more ▼]

This paper presents the results of the analysis of the very first dedicated X-ray observation with XMM-Newton of WR 106. This carbon-rich WC9d Wolf–Rayet star belongs to the category of persistent dust makers (WCd stars). The issue of the multiplicity of these dust makers is pivotal to understand the dust formation process, and in this context X-ray observations may allow to reveal an X-ray emission attributable to colliding-winds in a binary system. The main result of this analysis is the lack of detection of X-rays coming from WR 106. Upper limits on the X-ray flux are estimated, but the derived numbers are not sufficient to provide compelling constraints on the existence or not of a colliding-wind region. Detailed inspection of archive data bases reveals that persistent dust makers have been poorly investigated by the most sensitive X-ray observatories. Certainly, the combination of several approaches to indirectly constrain their multiplicity should be applied to lift a part of the veil on the nature of these persistent dust makers. [less ▲]

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See detailLa médecine de demain: science-fiction ou science-réalité ?
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2015), 9(6), 3-4

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See detailImpacts of underwater noise on marine vertebrates: Project introduction and first results
Liebschner, Alexander; Seibel, Henrike; Teilmann, Jonas et al

in Advances in Experimental Medicine and Biology (2015), 875

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See detailPosttraumatisches Puppen-Syndrom. Gedanken zu Jean Michel d'Hoops Inszenierung "Borgia. Comédie contemporaine"
Wunsch-Viehöver, Vera ULg

in Das Andere Theater (2015), 88

compte-rendu sur "Borgia. Comédie contemporaine" de Thomas Gunzig, mise en scène par Jean-Michel d'Hoop, cie. Point Zéro

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See detailGlobal optimization of the production and the distribution system for typical European HVAC systems
Randaxhe, François ULg; Lemort, Vincent ULg; Lebrun, Jean ULg

in Energy Procedia (2015), 78

European countries have agreed on a new 2030 Framework with a 30% improvement in energy efficiency compared to projection and a 40% cut in greenhouse gas emissions compared to 1990 levels. With an ... [more ▼]

European countries have agreed on a new 2030 Framework with a 30% improvement in energy efficiency compared to projection and a 40% cut in greenhouse gas emissions compared to 1990 levels. With an estimated 11% of all the electrical energy used in Europe consumed by HVAC systems, the improvement of their efficiency is a key element to reach these targets. When looking at the energy flow in typical European HVAC systems, one can observe important degradation in efficiency associated to heating and cooling energy transportation systems together with a non-optimal use of the production plant. These inefficiencies are direct consequences of the system design with, quite often, a lack of consideration of the system part load or its off-design operation. This research attempts to identify the sensitivity of both cooling and heating HVAC systems to these conditions and to propose an approach to optimize the design and the operation of HVAC systems integrated in buildings considering trade-off between primary systems efficiency, distribution losses and auxiliaries consumption. [less ▲]

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See detailLire entre les actes. Le théâtre mis en pièces par le récit d’anticipation
Stienon, Valérie ULg

in Tropics (2015), 2

Si les histoires de la littérature française font généralement peu de cas du roman d’anticipation, rendu invisible aux sélections de la postérité par la variété de ses désignations génériques, l’hybridité ... [more ▼]

Si les histoires de la littérature française font généralement peu de cas du roman d’anticipation, rendu invisible aux sélections de la postérité par la variété de ses désignations génériques, l’hybridité de ses formes et les discontinuités de son, ce dernier, en revanche, semble avoir des choses à dire au sujet de la littérature. Encore faut-il préciser de quel théâtre il est question dans ces anticipations, et dans quelle mesure il est possible de lire l’inscription d’un genre à travers la poétique d’un autre. Les thématisations du théâtre sont passibles d’une caractérisation multiforme impliquant des données d’ordre poétique, contextuel et historique. Plus qu’une définition de cette référence, la lecture transversale et diachronique de 1860 à 1930 qui suit entend formuler une interrogation sur les modalités de son traitement. Le théâtre participe-t-il, comme la poésie et le roman, et au même titre qu’eux, de la décadence anticipée des Lettres, signe d’un déclin général dont il prendrait acte à sa mesure ? Un genre ou un registre (drame, comédie, tragédie, boulevard, music-hall, vaudeville, opérette, etc.) est-il mis en évidence, ou ceux-ci sont-ils plutôt indifférenciés, voire présentés comme équivalents ? Ces considérations révèlent-elles une hybridation ou une remise en question des classements micro- et macro-génériques ? [less ▲]

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See detailThe aggressive personality of an introduced fish affects foraging behavior in a polymorphic newt
Winandy, Laurane ULg; Denoël, Mathieu ULg

in Behavioral Ecology (2015), 26(6), 1528-1536

The study of personality has aroused much interest and has provided insight into the understanding of animal behavior. Nevertheless, the study of the ecological consequences of personality is a newer ... [more ▼]

The study of personality has aroused much interest and has provided insight into the understanding of animal behavior. Nevertheless, the study of the ecological consequences of personality is a newer field that could shed light on cases of alien species introductions. The goldfish (Carassius auratus) is frequently introduced worldwide and affects the abundance of newts, having an especially negative impact on an alternative phenotype, the paedomorph, which maintains larval traits at the adult stage, unlike the other phenotype, the metamorph, which has undergone metamorphosis. We experimentally assessed the impact of goldfish on the foraging behavior of both phenotypes of palmate newts (Lissotriton helveticus). More particularly, we assessed fish personality by analyzing the foraging activity and the aggressiveness toward newts, and newt personality by analyzing individual difference in boldness. In the presence of fish, fewer newts foraged than in their absence, and paedomorphs were more affected than metamorphs. We found strong personality differences in fish and fewer newts foraged in the presence of a more aggressive fish. Newts differed in boldness, but fish aggressiveness remains a key factor to explain newt behavior. Studying behavioral interactions between native and alien species helps to understand the mechanisms of coexistence and exclusion and why different phenotypes might be affected differently by the same threat. To a great extent, not only the presence of fish alters the foraging opportunities of newts but also the personality of the invader; integrating personality patterns of invaders is therefore a key to understanding the ecological consequences of alien species introduction. [less ▲]

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See detailSmall RNA deep sequencing identifies viral microRNAs during malignant catarrhal fever induced by alcelaphine herpesvirus 1
Sorel, Océane ULg; Tuddenham, Lee; Myster, Françoise ULg et al

in Journal of General Virology (The) (2015), 96(11), 3360-3372

Alcelaphine herpesvirus 1 (AlHV-1) is a c-herpesvirus (c-HV) carried asymptomatically by wildebeest. Upon cross-species transmission, AlHV-1 induces a fatal lymphoproliferative disease named malignant ... [more ▼]

Alcelaphine herpesvirus 1 (AlHV-1) is a c-herpesvirus (c-HV) carried asymptomatically by wildebeest. Upon cross-species transmission, AlHV-1 induces a fatal lymphoproliferative disease named malignant catarrhal fever (MCF) in many ruminants, including cattle, and the rabbit model. Latency has been shown to be essential for MCF induction. However, the mechanisms causing the activation and proliferation of infected CD8+T cells are unknown. Many c-HVs express microRNAs (miRNAs). These small non-coding RNAs can regulate expression of host or viral target genes involved in various pathways and are thought to facilitate viral infection and/or mediate activation and proliferation of infected lymphocytes. The AlHV-1 genome has been predicted to encode a large number of miRNAs. However, their precise contribution in viral infection and pathogenesis in vivo remains unknown. Here, using cloning and sequencing of small RNAs we identified 36 potential miRNAs expressed in a lymphoblastoid cell line propagated from a calf infected with AlHV-1 and developing MCF. Among the sequenced candidate miRNAs, 32 were expressed on the reverse strand of the genome in two main clusters. The expression of these 32 viral miRNAs was further validated using Northern blot and quantitative reverse transcription PCR in lymphoid organs of MCF- developing calves or rabbits. To determine the concerted contribution in MCF of 28 viral miRNAs clustered in the non-protein-coding region of the AlHV-1 genome, a recombinant virus was produced. The absence of these 28 miRNAs did not affect viral growth in vitro or MCF induction in rabbits, indicating that the AlHV-1 miRNAs clustered in this non-protein-coding genomic region are dispensable for MCF induction. [less ▲]

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See detailModernisation des institutions judiciaires belges: vers un management de type 2.0
Schoenaers, Frédéric ULg

in Cahiers de la Sécurité (2015), 32

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See detailSI: Binominal Syntagms
Brems, Lieselotte ULg; De Clerck, Bernard; Verveckken, Katrien

in Language Sciences (2015)

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See detailBelgian Wildlife as Potential Zoonotic Reservoir of Hepatitis E virus
Thiry, Damien ULg; Mauroy, Axel ULg; Saegerman, Claude ULg et al

in Transboundary and Emerging Diseases (2015)

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See detailAllelic variation contributes to bacterial host specificity
Yue, Min; Han, Xiangan; De Masi, Leon et al

in Nature Communications (2015)

Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype ... [more ▼]

Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis of core genes within Salmonella enterica serovar Typhimurium genomes reveals a high degree of allelic variation in surface-exposed molecules, including adhesins that promote host colonization. Subsequent multinomial logistic regression, MultiPhen and Random Forest analyses of known/suspected adhesins from 580 independent Typhimurium isolates identifies distinct host-specific nsSNP signatures. Moreover, population and functional analyses of host-associated nsSNPs for FimH, the type 1 fimbrial adhesin, highlights the role of key allelic residues in host-specific adherence in vitro. Together, our data provide the first concrete evidence that functional differences between allelic variants of bacterial proteins likely contribute to pathoadaption to diverse hosts. [less ▲]

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See detailLyot-plane phase masks for improved high-contrast imaging with a vortex coronagraph
Ruane, Garreth J.; Huby, Elsa ULg; Absil, Olivier ULg et al

in Astronomy and Astrophysics (2015), 583

The vortex coronagraph is an optical instrument that precisely removes on-axis starlight allowing for high contrast imaging at small angular separation from the star, thereby providing a crucial ... [more ▼]

The vortex coronagraph is an optical instrument that precisely removes on-axis starlight allowing for high contrast imaging at small angular separation from the star, thereby providing a crucial capability for direct detection and characterization of exoplanets and circumstellar disks. Telescopes with aperture obstructions, such as secondary mirrors and spider support structures, require advanced coronagraph designs to provide adequate starlight suppression. We introduce a phase-only Lyot-plane optic to the vortex coronagraph that offers improved contrast performance on telescopes with complicated apertures. Potential solutions for the European Extremely Large Telescope (E-ELT) are described and compared. Adding a Lyot-plane phase mask relocates residual starlight away from a region of the image plane thereby reducing stellar noise and improving sensitivity to off-axis companions. The phase mask is calculated using an iterative phase retrieval algorithm. Numerically, we achieve a contrast on the order of $10^{-6}$ for a companion with angular displacement as small as $4~\lambda/D$ with an E-ELT type aperture. Even in the presence of aberrations, improved performance is expected compared to either a conventional vortex coronagraph or optimized pupil plane phase element alone. [less ▲]

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See detailA prospective 4 year study of the objective and subjective outcomes of 15 patients after dynamic facial reanimation surgery.
ANDREWS, Peter J; RANDHAWA, Premjit S; JOSEPH, Jonathan et al

in Clinical Otolaryngology (2015)

Facial nerve palsy is a debilitating and life changing event which significantly affects quality of life. This prospective study evaluates outcomes in 15 patients undergoing dynamic facial reanimation ... [more ▼]

Facial nerve palsy is a debilitating and life changing event which significantly affects quality of life. This prospective study evaluates outcomes in 15 patients undergoing dynamic facial reanimation surgery using a modification of the minimally invasive temporalis tendon transposition technique (MIT3) coupled with either static reanimation techniques or synergistic inter-positional/facial-hypoglossal nerve reconstruction techniques. All patients demonstrated significant improvement both objectively and subjectively as measured by the SMILE system and FaCE scale respectively. The MIT3 technique can be used successfully for dynamic reanimation and allows for other techniques to be simultaneously tailored around it. It provides improved functional and quality of life outcomes in patients and affords low morbidity. [less ▲]

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See detailA PHEROMONE TRAP MONITORING SYSTEM FOR THE SADDLE GALL MIDGE, Haplodiplosis marginata (von Roser) (DIPTERA: CECIDOMYIIDAE)
Censier, Florence ULg; Heuskin, Stéphanie ULg; SAN MARTIN Y GOMEZ, Gilles et al

in Crop Protection (2015), 80

Outbreaks of saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae) have been reported in Belgium and other European countries since 2010. Because of the sporadic nature of this ... [more ▼]

Outbreaks of saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae) have been reported in Belgium and other European countries since 2010. Because of the sporadic nature of this pest, which can sometimes be very harmful to cereal crops, an effective monitoring tool is required, both to determine the optimal timing for insecticide applications, and to understand the enigmatic population dynamics of this insect. Following the recent identification of the major sex pheromone component of the saddle gall midge, non-2-yl butanoate, a slow-release dispenser was developed using rubber septa. The release rates of 5 mg and 10 mg-loaded dispensers were initially measured under laboratory conditions, and their effectiveness in terms of pheromone loading and use duration was assessed in the field. The experiments showed that sticky traps baited with 5 mg pheromone-loaded rubber dispensers, renewed every 6 weeks, are suitable for accurately monitoring male H. marginata flights. [less ▲]

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See detailDivergent biophysical controls of aquatic CO2 and CH4 in the World’s two largest rivers
Borges, Alberto ULg; Abril, G; Darchambeau, François ULg et al

in Scientific Reports (2015), 5

Carbon emissions to the atmosphere from inland waters are globally significant and mainly occur at tropical latitudes. However, processes controlling the intensity of CO2 and CH4 emissions from tropical ... [more ▼]

Carbon emissions to the atmosphere from inland waters are globally significant and mainly occur at tropical latitudes. However, processes controlling the intensity of CO2 and CH4 emissions from tropical inland waters remain poorly understood. Here, we report a data-set of concurrent measurements of the partial pressure of CO2 (pCO2) and dissolved CH4 concentrations in the Amazon (n = 136) and the Congo (n = 280) Rivers. The pCO2 values in the Amazon mainstem were significantly higher than in the Congo, contrasting with CH4 concentrations that were higher in the Congo than in the Amazon. Large-scale patterns in pCO2 across different lowland tropical basins can be apprehended with a relatively simple statistical model related to the extent of wetlands within the basin, showing that, in addition to non-flooded vegetation, wetlands also contribute to CO2 in river channels. On the other hand, dynamics of dissolved CH4 in river channels are less straightforward to predict, and are related to the way hydrology modulates the connectivity between wetlands and river channels. [less ▲]

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See detailLe nouveau régime de tax shelter pour la production audiovisuelle
Vandenbulke, Antoine ULg

in Journal des Tribunaux (2015)

Description of the new tax shelter scheme in Belgium for companies wishing to invest in the production of an audiovisual work (Article 194ter CIR/1992), set up by the Law of May 12, 2014.

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See detailLa Cour constitutionnelle à nouveau au secours des ouvriers
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2015), (35), 1685-1687

L'étude commente l'arrêt 116/2015 de la Cour constitutionnelle annulant l'article 70, §4, de la loi sur le statut unique ainsi que l'alinéa de l’article 97 de la même loi, prévoyant l’exclusion permanente ... [more ▼]

L'étude commente l'arrêt 116/2015 de la Cour constitutionnelle annulant l'article 70, §4, de la loi sur le statut unique ainsi que l'alinéa de l’article 97 de la même loi, prévoyant l’exclusion permanente des ouvriers visés (une bonne partie des ouvriers de la construction) du bénéfice du régime uniforme des délais de préavis et la privation du droit à l’indemnité en compensation du licenciement. Le résultat de l'arrêt est que, jusqu’au 31 décembre 2017, les différences de traitement au détriment de certaines catégories d’ouvriers sont maintenues. Après cette date, l’article 70, paragraphe 4, disparaît de l’ordre juridique. L’article 70 sera, dans sa totalité, sans objet puisque la période transitoire aura pris fin. Tous les travailleurs, qu’ils soient ouvriers ou employés, seront égaux en droit : soit les durées seront identiques, soit la différence sera compensée par une indemnité spécifique à charge de l’ONEm. [less ▲]

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See detailInterpreting canopy development and physiology using a European phenology camera network at flux sites
Wingate, L.; Ogée, J.; Cremonese, E. et al

in Biogeosciences (2015), 12(10), 5995-6015

Plant phenological development is orchestrated through subtle changes in photoperiod, temperature, soil moisture and nutrient availability. Presently, the exact timing of plant development stages and ... [more ▼]

Plant phenological development is orchestrated through subtle changes in photoperiod, temperature, soil moisture and nutrient availability. Presently, the exact timing of plant development stages and their response to climate and management practices are crudely represented in land surface models. As visual observations of phenology are laborious, there is a need to supplement long-term observations with automated techniques such as those provided by digital repeat photography at high temporal and spatial resolution. We present the first synthesis from a growing observational network of digital cameras installed on towers across Europe above deciduous and evergreen forests, grasslands and croplands, where vegetation and atmosphere CO2 fluxes are measured continuously. Using colour indices from digital images and using piecewise regression analysis of time series, we explored whether key changes in canopy phenology could be detected automatically across different land use types in the network. The piecewise regression approach could capture the start and end of the growing season, in addition to identifying striking changes in colour signals caused by flowering and management practices such as mowing. Exploring the dates of green-up and senescence of deciduous forests extracted by the piecewise regression approach against dates estimated from visual observations, we found that these phenological events could be detected adequately (RMSE < 8 and 11 days for leaf out and leaf fall, respectively). We also investigated whether the seasonal patterns of red, green and blue colour fractions derived from digital images could be modelled mechanistically using the PROSAIL model parameterised with information of seasonal changes in canopy leaf area and leaf chlorophyll and carotenoid concentrations. From a model sensitivity analysis we found that variations in colour fractions, and in particular the late spring `green hump' observed repeatedly in deciduous broadleaf canopies across the network, are essentially dominated by changes in the respective pigment concentrations. Using the model we were able to explain why this spring maximum in green signal is often observed out of phase with the maximum period of canopy photosynthesis in ecosystems across Europe. Coupling such quasi-continuous digital records of canopy colours with co-located CO2 flux measurements will improve our understanding of how changes in growing season length are likely to shape the capacity of European ecosystems to sequester CO2 in the future. [less ▲]

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See detailFistula plug in fistulising ano-perineal Crohn's disease: a randomised controlled trial
Senéjoux, A.; Siproudhis, L.; Abramowitz, L. et al

in Journal of Crohn's and Colitis [=JCC] (2015)

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See detailCoupling and electrical control of structural, orbital and magnetic orders in perovskites
Varignon, Julien ULg; Bristowe, Nicholas ULg; Bousquet, Eric ULg et al

in Scientific Reports (2015), 5

Perovskite oxides are already widely used in industry and have huge potential for novel device applications thanks to the rich physical behaviour displayed in these materials. The key to the functional ... [more ▼]

Perovskite oxides are already widely used in industry and have huge potential for novel device applications thanks to the rich physical behaviour displayed in these materials. The key to the functional electronic properties exhibited by perovskites is often the so-called Jahn-Teller distortion. For applications, an electrical control of the Jahn-Teller distortions, which is so far out of reach, would therefore be highly desirable. Based on universal symmetry arguments, we determine new lattice mode couplings that can provide exactly this paradigm, and exemplify the effect from firstprinciples calculations. The proposed mechanism is completely general, however for illustrative purposes, we demonstrate the concept on vanadium based perovskites where we reveal an unprecedented orbital ordering and Jahn-Teller induced ferroelectricity. Thanks to the intimate coupling between Jahn-Teller distortions and electronic degrees of freedom, the electric field control of Jahn-Teller distortions is of general relevance and may find broad interest in various functional devices. [less ▲]

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See detailValproic acid improves second-line regimen of small cell lung carcinoma in preclinical models
Hubaux, Roland; Vandermeers, Fabian; Cosse, Jean-Philippe et al

in European Respiratory Society (2015), 1(2), 00028

With 5-year survival rates below 5%, small cell lung carcinoma (SCLC) has very poor prognosis and requires improved therapies. Despite an excellent overall response to first-line therapy, relapses are ... [more ▼]

With 5-year survival rates below 5%, small cell lung carcinoma (SCLC) has very poor prognosis and requires improved therapies. Despite an excellent overall response to first-line therapy, relapses are frequent and further treatments are disappointing. The goal of the study was to improve secondline therapy of SCLC. The effect of chemotherapeutic agents was evaluated in cell lines (apoptosis, reactive oxygen species, and RNA and protein expression) and in mouse models (tumour development). We demonstrate here that valproic acid, a histone deacetylase inhibitor, improves the efficacy of a second-line regimen (vindesine, doxorubicin and cyclophosphamide) in SCLC cells and in mouse models. Transcriptomic profiling integrating microRNA and mRNA data identifies key signalling pathways in the response of SCLC cells to valproic acid, opening new prospects for improved therapies. [less ▲]

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See detailHydroxyethyl Starch 130/0.4 and the Risk of Acute Kidney Injury After Cardiopulmonary Bypass: A Single-Center Retrospective Study.
LAGNY, Marc-Gilbert ULg; ROEDIGER, Laurence ULg; KOCH, Jean-Noël ULg et al

in Journal of Cardiothoracic and Vascular Anesthesia (2015)

Hydroxyethyl Starches (HES) have been shown to increase the risk of acute kidney injury (AKI) in intensive care unit patients suffering sepsis. Whether this risk also applies to patients undergoing ... [more ▼]

Hydroxyethyl Starches (HES) have been shown to increase the risk of acute kidney injury (AKI) in intensive care unit patients suffering sepsis. Whether this risk also applies to patients undergoing elective surgery remains unclear. We investigated whether HES is associated with acute kidney injury after on-pump cardiac surgery. Materials and Methods: Balanced HES 130/0.4 (Volulyte®, Fresenius Kabi AG, Bad Homburg, Germany) was used as a pump prime and for intraoperative fluid therapy until July 2013 and has been entirely replaced by a balanced crystalloid solution (Plasmalyte®, Baxter, Lessines, Belgium) from August 2013. Data from 697 adult patients undergoing cardiac surgery between April 2013 and June 2014 were reviewed. HES patients were propensity-matched on previously published risk factors for AKI after cardiac surgery to patients treated with crystalloids. Postoperative AKI was defined as the primary outcome and assessed using the Acute Kidney Injury Network classification. A conditional logistic regression was used to investigate the association between the use of HES and postoperative AKI. Secondary outcomes included renal function at postoperative day 7, 30-day mortality, lengths of ICU and hospital stays and the incidence of postoperative respiratory complications. Results and Discussion: One hundred and thirty HES patients were successfully matched with 130 crystalloids patients. HES was significantly associated with postoperative AKI (odds ratio=2.4; 95 % CI= 1.2-4.8; P=0.02). No significant association was found between HES and any of the secondary outcomes. Conclusion: This study suggests that using balanced HES 130/0.4 as a pump prime and for intraoperative fluid therapy in adult patients undergoing on-pump cardiac surgery is associated with a higher incidence of AKI during the early postoperative period. [less ▲]

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See detailVAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study
Berghmans, Thierry; Lafitte, Jean-Jacques; Scherpereel, Arnaud et al

in European Respiratory Society Open Research (2015), 1(2),

Salvage chemotherapy (CT) for relapsing or refractory small cell lung cancer (SCLC) remains disappointing. In vitro experiments showed that valproic acid increases apoptosis of SCLC cell lines exposed to ... [more ▼]

Salvage chemotherapy (CT) for relapsing or refractory small cell lung cancer (SCLC) remains disappointing. In vitro experiments showed that valproic acid increases apoptosis of SCLC cell lines exposed to doxorubicin, vindesine and bis(2-chloroethyl)amine. The primary objective of this phase II study was to determine whether epigenetic modulation with valproic acid in addition to a doxorubicin, vindesine and cyclophosphamide (VAC) regimen improves 6-month progression-free survival (PFS). Patients with pathologically proven SCLC refractory to prior platinum derivatives and etoposide were eligible. After central registration, patients received VAC plus daily oral valproic acid. 64 patients were registered, of whom six were ineligible. Seven patients did not receive any CT, leaving 51 patients assessable for the primary end-point. The objective response rate was 19.6%. Median PFS was 2.8 months (95% CI 2.5–3.6 months) and 6-month PFS was 6%. Median survival time was 5.9 months (95% CI 4.7–7.5 months). Toxicity was mainly haematological, with 88% and 26% grade 3–4 neutropenia and thrombopenia, respectively. Despite an interesting response rate, the addition of valproic acid to VAC did not translate into adequate PFS in relapsing SCLC or SCLC refractory to platinum–etoposide. [less ▲]

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See detailApplying participatory approaches in the evaluation of surveillance systems: A pilot study on African swine fever surveillance in Corsica.
Calba, Clémentine; Antoine-Moussiaux, Nicolas ULg; Charrier, François et al

in Preventive Veterinary Medicine (2015)

The implementation of regular and relevant evaluations of surveillance systems is critical in improving their effectiveness and their relevance whilst limiting their cost. The complex nature of these ... [more ▼]

The implementation of regular and relevant evaluations of surveillance systems is critical in improving their effectiveness and their relevance whilst limiting their cost. The complex nature of these systems and the variable contexts in which they are implemented call for the development of flexible evaluation tools. Within this scope, participatory tools have been developed and implemented for the African swine fever (ASF) surveillance system in Corsica (France). The objectives of this pilot study were, firstly, to assess the applicability of participatory approaches within a developed environment involving various stakeholders and, secondly, to define and test methods developed to assess evaluation attributes. Two evaluation attributes were targeted: the acceptability of the surveillance system and its the non-monetary benefits. Individual semi-structured interviews and focus groups were implemented with representatives from every level of the system. Diagramming and scoring tools were used to assess the different elements that compose the definition of acceptability. A contingent valuation method, associated with proportional piling, was used to assess the non-monetary benefits, i.e., the value of sanitary information. Sixteen stakeholders were involved in the process, through 3 focus groups and 8 individual semi-structured interviews. Stakeholders were selected according to their role in the system and to their availability. Results highlighted a moderate acceptability of the system for farmers and hunters and a high acceptability for other representatives (e.g., private veterinarians, local laboratories). Out of the 5 farmers involved in assessing the non-monetary benefits, 3 were interested in sanitary information on ASF. The data collected via participatory approaches enable relevant recommendations to be made, based on the Corsican context, to improve the current surveillance system. [less ▲]

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See detailComment améliorer la réussite à l’examen d’anatomie en 1re année de bachelier en médecine? Étude de l’impact d’une activité intégrée dans un dispositif hybride de formation
Ernst, Denise ULg; Van de Poël, Jean-François ULg; Verpoorten, Dominique ULg et al

in Revue Internationale des Technologies en Pédagogie Universitaire = International Journal of Technologies in Higher Education (2015), 11(3), 51-67

The course of “Introduction to Human Anatomy” is part of the curriculum delivered to the undergraduated students (Freshman year) at the Faculty of Medecine of the University of Liege. The course is taught ... [more ▼]

The course of “Introduction to Human Anatomy” is part of the curriculum delivered to the undergraduated students (Freshman year) at the Faculty of Medecine of the University of Liege. The course is taught in a blending learning mode combining traditional intructor-led and e-learning activities. The MCQ 2 test is one of the three components of the final written exam (which consists of 3 MCQtests). This test requires students to recognize and identify the organ’s orientation in cross-sections represented in different spatial views. In our study, we tried to evaluate how the online training exercises provided by the instructors team for that particular ability was appreciated by students and if students benefited from this type of online activities to improve their examination results for MCQ 2 test. Further in our research, we asked student about their perceptions of coherence between the aims, methods and evaluation of our entire system. Then this perception has been compared with the overall score of the exam to look for the present of correlation elements. We observed that the MCQ 2 test results are significantly better for students who practiced the new online exercises and for students having seen the value of this activity. The perception of consistency or coherence between the objectives, methods and assessment is not correlated to the overall score of the student. As conclusion, we can declare that the new learning scenario proposed positively enriches the learning environment for students. It can be easily scaled up for important groups and accessed at any time by users. It focusses on specific objectives, is directly linked to the examination system of the course (MCQ 2) and also allows developing a competence expertise related to their future medical profession. [less ▲]

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See detailA ‘nodeless’ dual superelement formulation for structural and multibody dynamics application to reduction of contact problems
Géradin, Michel ULg; Rixen, Daniel

in International Journal for Numerical Methods in Engineering (2015)

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See detailEctopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.
Xu, Xuewen; Ectors, Fabien ULg; Davis, Erica E. et al

in PloS one (2015), 10(10), 0140594

The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype ... [more ▼]

The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype. +Mat/CLPGPat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep. [less ▲]

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See detailShear banding modelling in cross-anisotropic rocks
Pardoen, Benoît ULg; Seyedi, D.M.; Collin, Frédéric ULg

in International Journal of Solids and Structures (2015), 72

Sedimentary geomaterials such as rocks frequently exhibit cross-anisotropic properties and their behaviour depends on the direction of loading with respect to their microstructure. As far as material ... [more ▼]

Sedimentary geomaterials such as rocks frequently exhibit cross-anisotropic properties and their behaviour depends on the direction of loading with respect to their microstructure. As far as material rupture is concerned, localised deformation in shear band mode appears generally before cracks and material failure. The influence of cross-anisotropy on the shear strain localisation remains an important issue and is investigated in the present study. To do so, a constitutive elastoplastic cross-anisotropic model that includes anisotropy both on the elastic and plastic characteristics is defined. For the plastic part of the model, the anisotropy of a strength parameter is introduced with a microstructure fabric tensor. Then, the fractures are modelled with finite element methods by considering the development of shear strain localisation bands and an enriched model is used to properly reproduce the shear banding. The cross-anisotropy influence on shear banding is studied through numerical applications of small and large-scale geotechnical problems that engender fractures. The two considered applications are a plane-strain biaxial compression test and an underground gallery excavation. The numerical results provide information about the influence of cross-anisotropy on the appearance and development of shear bands. It has been noticed, among other observations, that the material strength vary with the loading direction and that the development and the shape of the excavation fractured zone that develops around a gallery is strongly influenced by the material anisotropy. [less ▲]

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See detailA Compact Concentration of Large Grains in the HD 142527 Protoplanetary Dust Trap
Casassus, Simon; Wright, Chris; Marino, Sebastian et al

in Astrophysical Journal (2015)

A pathway to the formation of planetesimals, and eventually giant planets, may occur in concentrations of dust grains trapped in pressure maxima. Dramatic crescent-shaped dust concentrations have been ... [more ▼]

A pathway to the formation of planetesimals, and eventually giant planets, may occur in concentrations of dust grains trapped in pressure maxima. Dramatic crescent-shaped dust concentrations have been seen in recent radio images at submillimeter wavelengths. These disk asymmetries could represent the initial phases of planet formation in the dust trap scenario, provided that grain sizes are spatially segregated. A testable prediction of azimuthal dust trapping is that progressively larger grains should be more sharply confined and should follow a distribution that is markedly different from the gas. However, gas tracers such as 12CO and the infrared emission from small grains are both very optically thick where the submillimeter continuum originates, so previous observations have been unable to test the trapping predictions or to identify compact concentrations of larger grains required for planet formation by core accretion. Here we report multifrequency observations of HD 142527, from 34 to 700 GHz, that reveal a compact concentration of grains approaching centimeter sizes, with a few Earth masses, embedded in a large-scale crescent of smaller, submillimeter-sized particles. The emission peaks at wavelengths shorter than ∼1 mm are optically thick and trace the temperature structure resulting from shadows cast by the inner regions. Given this temperature structure, we infer that the largest dust grains are concentrated in the 34 GHz clump. We conclude that dust trapping is efficient enough for grains observable at centimeter wavelengths to lead to compact concentrations. [less ▲]

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See detailGuided group purchases of energy renovation services and works in deprived urban neighbourhoods
Ruelle, Christine ULg; Teller, Jacques ULg

in Energy Efficiency (2015)

The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this ... [more ▼]

The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this process. This paper explores the use of a method called ‘Guided Group Purchases’ (GPPs), i.e. an approach combining support, guidance and group purchasing of energy renovation services and works, as a possible method to accelerate the retrofitting of the existing housing stock. It reports on an action research experiment conducted in the context of the Interreg project ‘SUN’ (Sustainable Urban Neighbourhoods). The results of this experiment are quite promising. Within a few months, some 80 energy retrofitting interventions (energy audits or insulation works) were implemented in one neighbourhood of the city of Liège. Our evaluation of the experiment showed that the prospect of achieving cost reductions was one of the main initial expectations of participants to the GGPs. Still the participants rather insisted on other benefits after taking part to the initiative. These benefits were mostly related to the guidance they received, to the facilitation with contractors and to the social dynamics generated by the initiative. Several weaknesses were also identified by participants, like the lack of follow-up during and after the works. Our evaluation also highlighted that the main landlords did not participate in the initiative and that the influence of GGPs on costs was limited to specific types of interventions. Despite observed limitations and possible improvements, such a neighbourhood-based approach certainly constitutes a promising avenue for public authorities to support and accelerate the energy retrofitting of private residential buildings in urban neighbourhoods. [less ▲]

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See detailDirect exoplanet detection and characterization using the ANDROMEDA method: Performance on VLT/NaCo data
Cantalloube, F.; Mouillet, D.; Mugnier, L. M. et al

in Astronomy and Astrophysics (2015), 582

Context. The direct detection of exoplanets with high-contrast imaging requires advanced data processing methods to disentangle potential planetary signals from bright quasi-static speckles. Among them ... [more ▼]

Context. The direct detection of exoplanets with high-contrast imaging requires advanced data processing methods to disentangle potential planetary signals from bright quasi-static speckles. Among them, angular differential imaging (ADI) permits potential planetary signals with a known rotation rate to be separated from instrumental speckles that are either statics or slowly variable. The method presented in this paper, called ANDROMEDA for ANgular Differential OptiMal Exoplanet Detection Algorithm is based on a maximum likelihood approach to ADI and is used to estimate the position and the flux of any point source present in the field of view. Aims. In order to optimize and experimentally validate this previously proposed method, we applied ANDROMEDA to real VLT/NaCo data. In addition to its pure detection capability, we investigated the possibility of defining simple and efficient criteria for automatic point source extraction able to support the processing of large surveys. Methods. To assess the performance of the method, we applied ANDROMEDA on VLT/NaCo data of TYC-8979-1683-1 which is surrounded by numerous bright stars and on which we added synthetic planets of known position and flux in the field. In order to accommodate the real data properties, it was necessary to develop additional pre-processing and post-processing steps to the initially proposed algorithm. We then investigated its skill in the challenging case of a well-known target, $\beta$ Pictoris, whose companion is close to the detection limit and we compared our results to those obtained by another method based on principal component analysis (PCA). Results. Application on VLT/NaCo data demonstrates the ability of ANDROMEDA to automatically detect and characterize point sources present in the image field. We end up with a robust method bringing consistent results with a sensitivity similar to the recently published algorithms, with only two parameters to be fine tuned. Moreover, the companion flux estimates are not biased by the algorithm parameters and do not require a posteriori corrections. Conclusions. ANDROMEDA is an attractive alternative to current standard image processing methods that can be readily applied to on-sky data. [less ▲]

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See detailA lysine cluster in domain II of Bacillus subtilis PBP4a plays a role in the membrane attachment of this C1-PBP
Vanden Broeck, Arnaud; Van Der Heiden, Edwige ULg; Sauvage, Eric ULg et al

in PLoS ONE (2015)

In PBP4a, a Bacillus subtilis class-C1 penicillin-binding protein (PBP), four clustered lysine (K) residues, K86, K114, K119, and K265, protrude from domain II. Replacement of these amino acids with ... [more ▼]

In PBP4a, a Bacillus subtilis class-C1 penicillin-binding protein (PBP), four clustered lysine (K) residues, K86, K114, K119, and K265, protrude from domain II. Replacement of these amino acids with glutamine (Q) residues by site-directed mutagenesis yielded Mut4KQ PBP4a. When produced in Escherichia coli without its predicted Sec-signal peptide, wildtype (WT) PBP4a was found mainly associated with the host cytoplasmic membrane, whereas Mut4KQ PBP4a remained largely unbound. After purification, the capacities of the two proteins to bind to B. subtilis membranes were compared. The results were similar to those obtained in E. coli: in vitro, a much higher percentage of WT PBP4a than of Mut4KQ PBP4a was found to interact with B. subtilis membranes. Immunodetection of PBP4a in B. subtilis membrane extracts revealed that a processed form of this PBP (as indicated by its size) associates with the B. subtilis cytoplasmic membrane. In the absence of any amphiphilic peptide in PBP4a, the crown of positive charges on the surface of domain II is likely responsible for the cellular localization of this PBP and its attachment to the cytoplasmic membrane. [less ▲]

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See detailData Product Specification Proposal for Architectural Heritage Documentation with Photogrammetric Techniques: A Case Study in Brazil
Campos, Mariana; Tommaselli, Antonio; Ivanova, Ivana et al

in Remote Sensing (2015), 7(10), 13337-13363

Photogrammetric documentation can provide a sound database for the needs of architectural heritage preservation. However, the major part of photogrammetric documentation production is not used for ... [more ▼]

Photogrammetric documentation can provide a sound database for the needs of architectural heritage preservation. However, the major part of photogrammetric documentation production is not used for subsequent architectural heritage projects, due to lack of knowledge of photogrammetric documentation accuracy. In addition, there are only a few studies with rigorous analysis of the requirements for photogrammetric documentation of architectural heritage. In particular, requirements focusing on the geometry of the models generated by fully digital photogrammetric processes are missing. Considering these needs, this paper presents a procedure for architectural heritage documentation with photogrammetric techniques based on a previous review of existing standards of architectural heritage documentation. The data product specification proposed was elaborated conforming to ISO 19131 recommendations. We present the procedure with two case studies in the context of Brazilian architectural heritage documentation. Quality analysis of the produced models were performed considering ISO 19157 elements, such as positional accuracy, logical consistency and completeness, meeting the requirements. Our results confirm that the proposed requirements for photogrammetric documentation are viable. [less ▲]

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See detailParameter estimation and inference in dynamic systems described by linear partial differential equations
Frasso, Gianluca ULg; Jeager, Jonathan; Lambert, Philippe ULg

in AStA Advances in Statistical Analysis (2015)

Differential equations (DEs) are commonly used to describe dynamic sys- tems evolving in one (ordinary differential equations or ODEs) or in more than one dimensions (partial differential equations or ... [more ▼]

Differential equations (DEs) are commonly used to describe dynamic sys- tems evolving in one (ordinary differential equations or ODEs) or in more than one dimensions (partial differential equations or PDEs). In real data applications, the para- meters involved in the DE models are usually unknown and need to be estimated from the available measurements together with the state function. In this paper, we present frequentist and Bayesian approaches for the joint estimation of the parameters and of the state functions involved in linear PDEs. We also propose two strategies to include state (initial and/or boundary) conditions in the estimation procedure. We evaluate the performances of the proposed strategy through simulated examples and a real data analysis involving (known and necessary) state conditions. [less ▲]

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See detailWhy is later age at retirement beneficial for cognition? Results from a French population-based study
Grotz, Catherine ULg; Meillon, Céline; Amieva, Hélène et al

in Journal of Nutrition, Health & Aging (2015)

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See detailEffect of Metals, Metalloids and Metallic Nanoparticles on Microalgae Growth and Industrial Product Biosynthesis: A Review
Miazek, Krystian ULg; Iwanek, Waldemar; Remacle, Claire ULg et al

in International Journal of Molecular Sciences (2015), 16

Microalgae are a source of numerous compounds that can be used in many branches of industry. Synthesis of such compounds in microalgal cells can be amplified under stress conditions. Exposure to various ... [more ▼]

Microalgae are a source of numerous compounds that can be used in many branches of industry. Synthesis of such compounds in microalgal cells can be amplified under stress conditions. Exposure to various metals can be one of methods applied to induce cell stress and synthesis of target products in microalgae cultures. In this review, the potential of producing diverse biocompounds (pigments, lipids, exopolymers, peptides, phytohormones, arsenoorganics, nanoparticles) from microalgae cultures upon exposure to various metals, is evaluated. Additionally, different methods to alter microalgae response towards metals and metal stress are described. Finally, possibilities to sustain high growth rates and productivity of microalgal cultures in the presence of metals are discussed. [less ▲]

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See detailRÉGIME ALIMENTAIRE ET STRATÉGIE TROPHIQUE SAISONNIÈRE DE LA LOUTRE D’EUROPE, LUTRA LUTRA, DANS LE MOYEN ATLAS (MAROC)
Libois, Roland ULg; Fareh, Mostafa; Brahimi, Amina et al

in Revue d'Ecologie (La Terre et la Vie) (2015), 70(4), 314-327

To learn more about the adaptability and predation behaviour of the European Otter (Lutra lutra) in semi-arid regions, its diet has been studied in Wadi Beth, a typical river of Middle Atlas (Morocco ... [more ▼]

To learn more about the adaptability and predation behaviour of the European Otter (Lutra lutra) in semi-arid regions, its diet has been studied in Wadi Beth, a typical river of Middle Atlas (Morocco), from its source areas (Azrou) to El Kansera hill reservoir dam. Fecal samples (spraints) were systematically collected from six locations during two annual cycles, a collection per season campaign. The study reveals that the otter’s diet is classic (dominant fish), very typical and characteristic of aquatic ecosystems in arid Mediterranean climate, which is reflected in particular by the singular presence of prey like reptiles. Prey species richness totals more than 18 species. Moreover, the frequency of occurrence and relative abundance of taxa consumed were calculated from 2444 identified prey. Fish represent more than 75 % of the prey (relative abundance) with a very large predominance of 3 species of barbels. The anuran amphibians constitute 15 % of the prey. The rest is accounted for, according their respective importance, by insects, ophidians, a chelonian (Mauremys leprosa), birds, crustaceans and finally small mammals. Over time, the diet changed: in autumn 2010, cichlids, introduced into the river, appeared in the prey consumed. The proportion of prey types abruptly changed: perciforms, rare in spring and summer 2010 (less than 4 % of the prey) increased sevenfold in autumn 2010 (27 %) and then declined in the spring and more in summer 2011. In summer 2011, the proportion of barbels dropped, drastically offset by salmonids and, even more, by amphibians. In summer, the proportion of amphibians and ophidians becomes more important. Site variations are linked to local conditions: presence of ponds, nature of the bottom, slope, speed and flow of the water, etc. Finally, small-sized fish (salmonids and barbels) dominate the diet: 80 % are less than 10 cm. [less ▲]

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See detailThe onset, evolution and magnetic braking of vortex lattice instabilities in nanostructured superconducting films
Adami, Obaïd-Allah ULg; Jelic, Zeljko ULg; Xue, Cun et al

in Physical Review. B : Condensed Matter (2015), 92

In 1976 Larkin and Ovchinnikov [Sov. Phys. JETP 41, 960 (1976)] predicted that vortex matter in superconductors driven by an electrical current can undergo an abrupt dynamic transition from a flux-flow ... [more ▼]

In 1976 Larkin and Ovchinnikov [Sov. Phys. JETP 41, 960 (1976)] predicted that vortex matter in superconductors driven by an electrical current can undergo an abrupt dynamic transition from a flux-flow regime to a more dissipative state at suficiently high vortex velocities. Typically this transition manifests itself as a large voltage jump at a particular current density, so-called instability current density J, which is smaller than the depairing current. By tuning the effective pinning strength in Al fi lms, using an artifi cial periodic pinning array of triangular holes, we show that a unique and well defi ned instability current density exists if the pinning is strong, whereas a series of multiple voltage transitions appear in the relatively weaker pinning regime. This behavior is consistent with time-dependent Ginzburg-Landau simulations, where the multiple-step transition can be unambiguously attributed to the progressive development of vortex chains and subsequently phase-slip lines. In addition, we explore experimentally the magnetic braking e ffects, caused by a thick Cu layer deposited on top of the superconductor, on the instabilities and the vortex ratchet effect. [less ▲]

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See detailAntioxidant phenolic extracts obtained from secondary Tunisian date varieties (Phoenix dactylifera L.) by hydrothermal treatments
Mrabet, Abdessalem ULg; Jiménez-Araujo, Ana; Fernández-Bolaños, Juan et al

in Food Chemistry (2015), 196(2016), 917-924

Three common non-commercial Tunisian date varieties were treated by two thermal systems, obtaining a liquid fraction which was characterized and its antioxidant capacity determined. The concentration of ... [more ▼]

Three common non-commercial Tunisian date varieties were treated by two thermal systems, obtaining a liquid fraction which was characterized and its antioxidant capacity determined. The concentration of total phenols in the three varieties (Smeti, Garen Gazel, and Eguwa) was increased by steam explosion treatment up to 5311, 4680, and 3832 mg/kg of fresh dates, and their antioxidant activity up to 62.5, 46.5 and 43.1 mmol Trolox®/kg of fresh date, respectively. Both thermal treatments increased the content of phenolic acids. Additionally, a long scale study was carried out in a pilot plant, with steam treatment at 140 °C and 160 °C for 30 min. The liquid phase was extracted and fractionated chromatographically using adsorbent or ionic resins. The phenolic profiles were determined for each fraction, yielding fractions with interesting antioxidant activities with EC50 values of up to 0.08 mg/L or values of TEAC of 0.67 mmol Trolox®/g of extract. [less ▲]

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See detailEvidence for two spatially separated UV continuum emitting regions in the Cloverleaf broad absorption line quasar
Sluse, Dominique ULg; Hutsemekers, Damien ULg; Anguita, T. et al

in Astronomy and Astrophysics (2015), 582

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing ... [more ▼]

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing in gravitationally lensed quasars is one of the few techniques that can test this model, yielding to the measurement of the size and of temperature profile of the accretion disc. We present spectroscopic observations of the gravitationally lensed broad absorption line quasar H1413+117, which reveal partial microlensing of the continuum emission that appears to originate from two separated regions: a microlensed region, corresponding the compact accretion disc; and a non-microlensed region, more extended and contributing to at least 30% of the total UV-continuum flux. Because this extended continuum is occulted by the broad absorption line clouds, it is not associated with the host galaxy, but rather with light scattered in the neighbourhood of the central engine. We measure the amplitude of microlensing of the compact continuum over the rest-frame wavelength range 1000-7000 Å. Following a Bayesian scheme, we confront our measurements to microlensing simulations of an accretion disc with a temperature varying as T ∝ R[SUP]-1/ν[/SUP]. We find a most likely source half-light radius of R[SUB]1/2[/SUB] = 0.61 × 10[SUP]16[/SUP]cm (i.e., 0.002 pc) at 0.18 μm, and a most-likely index of ν = 0.4. The standard disc (ν = 4/3) model is not ruled out by our data, and is found within the 95% confidence interval associated with our measurements. We demonstrate that, for H1413+117, the existence of an extended continuum in addition to the disc emission only has a small impact on the inferred disc parameters, and is unlikely to solve the tension between the microlensing source size and standard disc sizes, as previously reported in the literature. Based on observations made with ESO Telescopes at the Paranal Observatory (Chile). ESO program ID: 386.B-0337.Appendices A and B are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201526832/olm">http://www.aanda.org</A> [less ▲]

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See detailTests of the Planetary Hypothesis for PTFO 8-8695b
Yu, Liang; Winn, Joshua N.; Gillon, Michaël ULg et al

in Astrophysical Journal (2015), 812

The T Tauri star PTFO 8-8695 exhibits periodic fading events that have been interpreted as the transits of a giant planet on a precessing orbit. Here we present three tests of the planet hypothesis. First ... [more ▼]

The T Tauri star PTFO 8-8695 exhibits periodic fading events that have been interpreted as the transits of a giant planet on a precessing orbit. Here we present three tests of the planet hypothesis. First, we sought evidence for the secular changes in light-curve morphology that are predicted to be a consequence of orbital precession. We observed 28 fading events spread over several years and did not see the expected changes. Instead, we found that the fading events are not strictly periodic. Second, we attempted to detect the planet's radiation, based on infrared observations spanning the predicted times of occultations. We ruled out a signal of the expected amplitude. Third, we attempted to detect the Rossiter-McLaughlin effect by performing high-resolution spectroscopy throughout a fading event. No effect was seen at the expected level, ruling out most (but not all) possible orientations for the hypothetical planetary orbit. Our spectroscopy also revealed strong, time-variable, high-velocity Hα and Ca H & K emission features. All these observations cast doubt on the planetary hypothesis, and suggest instead that the fading events represent starspots, eclipses by circumstellar dust, or occultations of an accretion hotspot. [less ▲]

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See detailZigzag antiferromagnetic quantum ground state in monoclinic honeycomb lattice antimonates A3Ni2SbO6 (A=Li, Na)
Zvereva, E.A.; Stratan, M.I.; Ovchenkov, Y.A. et al

in Physical Review. B: Condensed Matter and Materials Physics (2015), 92

We present a comprehensive experimental and theoretical study of the electronic and magnetic properties of two quasi-two-dimensional (2D) honeycomb-lattice monoclinic compounds A3Ni2SbO6 (A=Li, Na ... [more ▼]

We present a comprehensive experimental and theoretical study of the electronic and magnetic properties of two quasi-two-dimensional (2D) honeycomb-lattice monoclinic compounds A3Ni2SbO6 (A=Li, Na). Magnetic susceptibility and specific heat data are consistent with the onset of antiferromagnetic (AFM) long range order at low temperatures with Néel temperatures ~ 14 and 16 K for Li3Ni2SbO6 and Na3Ni2SbO6, respectively. The effective magnetic moments of 4.3 Bohr magnetons/f.u. (Li3Ni2SbO6) and 4.4 Bohr magnetons/f.u. (Na3Ni2SbO6) indicate that Ni2+ is in a high-spin configuration (S=1). The temperature dependence of the inverse magnetic susceptibility follows the Curie-Weiss law in the high-temperature region and shows positive values of the Weiss temperature ~ 8 K (Li3Ni2SbO6) and ~12 K (Na3Ni2SbO6) pointing to the presence of non-negligible ferromagnetic interactions, although the system orders AFM at low temperatures. In addition, the magnetization curves reveal a field-induced (spin-flop type) transition below TN that can be related to the magnetocrystalline anisotropy in these systems. These observations are in agreement with density functional theory calculations, which show that both antiferromagnetic and ferromagnetic intralayer spin exchange couplings between Ni2+ ions are present in the honeycomb planes supporting a zigzag antiferromagnetic ground state. Based on our experimental measurements and theoretical calculations we propose magnetic phase diagrams for the two compounds. [less ▲]

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See detailKIC 4768731: a bright long-period roAp star in the Kepler field
Smalley, B.; Niemczura, E.; Murphy, S. J. et al

in Monthly Notices of the Royal Astronomical Society (2015), 452

We report the identification of 61.45 d[SUP]-1[/SUP] (711.2 μHz) oscillations, with amplitudes of 62.6 μmag, in KIC 4768731 (HD 225914) using Kepler photometry. This relatively bright (V = 9.17 ... [more ▼]

We report the identification of 61.45 d[SUP]-1[/SUP] (711.2 μHz) oscillations, with amplitudes of 62.6 μmag, in KIC 4768731 (HD 225914) using Kepler photometry. This relatively bright (V = 9.17) chemically peculiar star with spectral type A5 Vp SrCr(Eu) has previously been found to exhibit rotational modulation with a period of 5.21 d. Fourier analysis reveals a simple dipole pulsator with an amplitude that has remained stable over a 4-yr time span, but with a frequency that is variable. Analysis of high-resolution spectra yields stellar parameters of T[SUB]eff[/SUB] = 8100 ± 200 K, log g = 4.0 ± 0.2, [Fe/H] = +0.31 ± 0.24 and v sin i = 14.8 ± 1.6 km s[SUP]-1[/SUP]. Line profile variations caused by rotation are also evident. Lines of Sr, Cr, Eu, Mg and Si are strongest when the star is brightest, while Y and Ba vary in antiphase with the other elements. The abundances of rare earth elements are only modestly enhanced compared to other roAp stars of similar T[SUB]eff[/SUB] and log g. Radial velocities in the literature suggest a significant change over the past 30 yr, but the radial velocities presented here show no significant change over a period of 4 yr. [less ▲]

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See detailThe far-ultraviolet main auroral emission at Jupiter – Part 2: Vertical emission profile
Bonfond, Bertrand ULg; Gustin, Jacques ULg; Gérard, Jean-Claude ULg et al

in Annales Geophysicae (2015), 33

The aurorae at Jupiter are made up of many different features associated with a variety of generation mechanisms. The main auroral emission, also known as the main oval, is the most prominent of them as ... [more ▼]

The aurorae at Jupiter are made up of many different features associated with a variety of generation mechanisms. The main auroral emission, also known as the main oval, is the most prominent of them as it accounts for approximately half of the total power emitted by the aurorae in the ultraviolet range. The energy of the precipitating electrons is a crucial parameter to characterize the processes at play which give rise to these auroral emissions, and the altitude of the emissions directly depends on this energy. Here we make use of far-UV (FUV) images acquired with the Advanced Camera for Surveys on board the Hubble Space Telescope and spectra acquired with the Space Telescope Imaging Spectrograph to measure the vertical profile of the main emissions. The altitude of the brightness peak as seen above the limb is ~ 400 km, which is significantly higher than the 250 km measured in the post-dusk sector by Galileo in the visible domain. However, a detailed analysis of the effect of hydrocarbon absorption, including both simulations and FUV spectral observations, indicates that FUV apparent vertical profiles should be considered with caution, as these observations are not incompatible with an emission peak located at 250 km. The analysis also calls for spectral observations to be carried out with an optimized geometry in order to remove observational ambiguities. [less ▲]

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See detailThe far-ultraviolet main auroral emission at Jupiter – Part 1: Dawn–dusk brightness asymmetries
Bonfond, Bertrand ULg; Gustin, Jacques ULg; Gérard, Jean-Claude ULg et al

in Annales Geophysicae (2015), 33

The main auroral emission at Jupiter generally appears as a quasi-closed curtain centered around the magnetic pole. This auroral feature, which accounts for approximately half of the total power emitted ... [more ▼]

The main auroral emission at Jupiter generally appears as a quasi-closed curtain centered around the magnetic pole. This auroral feature, which accounts for approximately half of the total power emitted by the aurorae in the ultraviolet range, is related to corotation enforcement currents in the middle magnetosphere. Early models for these currents assumed axisymmetry, but significant local time variability is obvious on any image of the Jovian aurorae. Here we use far-UV images from the Hubble Space Telescope to further characterize these variations on a statistical basis. We show that the dusk side sector is ~ 3 times brighter than the dawn side in the southern hemisphere and ~ 1.1 brighter in the northern hemisphere, where the magnetic anomaly complicates the interpretation of the measurements. We suggest that such an asymmetry between the dawn and the dusk sectors could be the result of a partial ring current in the nightside magnetosphere. [less ▲]

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See detailHalomethyl-cobalt(bis-acetylacetonate) for the controlled synthesis of functional polymers
Demarteau, Jérémy ULg; Kermagoret, Anthony; German, Ian et al

in Chemical Communications (2015), 51(76), 14334-14337

Novel organocobalt complexes featuring weak C–CoL2 bonds (L = acetylacetonate) are prepared and used as sources of halomethyl radicals. They permit the precision synthesis of a-halide functionalized and ... [more ▼]

Novel organocobalt complexes featuring weak C–CoL2 bonds (L = acetylacetonate) are prepared and used as sources of halomethyl radicals. They permit the precision synthesis of a-halide functionalized and telechelic polymers in organic media or in water. Substitution of halide by azide allows derivatization of polymers using the CuAAC click reaction. [less ▲]

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See detailThe K2-ESPRINT Project I: Discovery of the Disintegrating Rocky Planet K2-22b with a Cometary Head and Leading Tail
Sanchis-Ojeda, R.; Rappaport, S.; Pallé, E. et al

in Astrophysical Journal (2015), 812(2), 112

We present the discovery of a transiting exoplanet candidate in the K2 Field-1 with an orbital period of 9.1457 hr: K2-22b. The highly variable transit depths, ranging from ∼0% to 1.3%, are suggestive of ... [more ▼]

We present the discovery of a transiting exoplanet candidate in the K2 Field-1 with an orbital period of 9.1457 hr: K2-22b. The highly variable transit depths, ranging from ∼0% to 1.3%, are suggestive of a planet that is disintegrating via the emission of dusty effluents. We characterize the host star as an M-dwarf with Teff ≃ 3800 K. We have obtained ground-based transit measurements with several 1-m class telescopes and with the GTC. These observations (1) improve the transit ephemeris; (2) confirm the variable nature of the transit depths; (3) indicate variations in the transit shapes; and (4) demonstrate clearly that at least on one occasion the transit depths were significantly wavelength dependent. The latter three effects tend to indicate extinction of starlight by dust rather than by any combination of solid bodies. The K2 observations yield a folded light curve with lower time resolution but with substantially better statistical precision compared with the ground-based observations. We detect a significant “bump” just after the transit egress, and a less significant bump just prior to transit ingress. We interpret these bumps in the context of a planet that is not only likely streaming a dust tail behind it, but also has a more prominent leading dust trail that precedes it. This effect is modeled in terms of dust grains that can escape to beyond the planet's Hill sphere and effectively undergo “Roche lobe overflow,” even though the planet's surface is likely underfilling its Roche lobe by a factor of 2. [less ▲]

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See detailStroboscopic phenomena in superconductors with dynamic pinning landscape
Jelic, Zeljko ULg; Milosevic, Milorad; Van de Vondel, Joris et al

in Scientific Reports (2015), 5

Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain ... [more ▼]

Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain without dissipation. In case of spatially periodic pinning, a clear enhancement of the superconducting critical current arises when commensurability between the vortex configurations and the pinning landscape occurs. With recent achievements in (ultrafast) optics and nanoengineered plasmonics it has become possible to exploit the interaction of light with superconductivity, and create not only spatially periodic imprints on the superconducting condensate, but also temporally periodic ones. Here we show that in the latter case, temporal matching phenomena develop, caused by stroboscopic commensurability between the characteristic frequency of the vortex motion under applied current and the frequency of the dynamic pinning. The matching resonances persist in a broad parameter space, including magnetic field, driving current, or material purity, giving rise to unusual features such as externally variable resistance/impedance and Shapiro steps in current-voltage characteristics. All features are tunable by the frequency of the dynamic pinning landscape. These findings open further exploration avenues for using flashing, spatially engineered, and/or mobile excitations on superconductors, permitting us to achieve advanced functionalities. [less ▲]

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See detailKepler's first view of O-star variability: K2 data of five O stars in Campaign 0 as a proof of concept for O-star asteroseismology
Buysschaert, B.; Aerts, C.; Bloemen, S. et al

in Monthly Notices of the Royal Astronomical Society (2015), 453

We present high-precision photometric light curves of five O-type stars observed with the refurbished Kepler satellite during its Campaign 0. For one of the stars, we also assembled high-resolution ground ... [more ▼]

We present high-precision photometric light curves of five O-type stars observed with the refurbished Kepler satellite during its Campaign 0. For one of the stars, we also assembled high-resolution ground-based spectroscopy with the HERMES spectrograph attached to the 1.2 m Mercator telescope. The stars EPIC 202060097 (O9.5V) and EPIC 202060098 (O7V) exhibit monoperiodic variability due to rotational modulation with an amplitude of 5.6 and 9.3 mmag and a rotation period of 2.63 and 5.03 d, respectively. EPIC 202060091 (O9V) and EPIC 202060093 (O9V:pe) reveal variability at low frequency but the cause is unclear. EPIC 202060092 (O9V:p) is discovered to be a spectroscopic binary with at least one multiperiodic β Cep-type pulsator whose detected mode frequencies occur in the range [0.11, 6.99] d[SUP]-1[/SUP] and have amplitudes between 0.8 and 2.0 mmag. Its pulsation spectrum is shown to be fully compatible with the ones predicted by core-hydrogen burning O-star models. Despite the short duration of some 33 d and the limited data quality with a precision near 100 μmag of these first K2 data, the diversity of possible causes for O-star variability already revealed from campaigns of similar duration by the MOST and CoRoT satellites is confirmed with Kepler. We provide an overview of O-star space photometry and give arguments why future K2 monitoring during Campaigns 11 and 13 at short cadence, accompanied by time-resolved high-precision high-resolution spectroscopy, opens up the possibility of in-depth O-star seismology. [less ▲]

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See detailHunting for Planets in the HL Tau Disk
Testi, L.; Skemer, A.; Henning, Th et al

in Astrophysical Journal Letters (2015), 812

Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet ... [more ▼]

Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet formation, probably in a gravitationally unstable disk. To test this scenario, we searched for young planets by means of direct imaging in the L‧ band using the Large Binocular Telescope Interferometer mid-infrared camera. At the location of two prominent dips in the dust distribution at ˜70 AU (˜0.″5) from the central star, we reach a contrast level of ˜7.5 mag. We did not detect any point sources at the location of the rings. Using evolutionary models we derive upper limits of ˜10-15 M[SUB]Jup[/SUB] at ≤0.5-1 Ma for the possible planets. With these sensitivity limits we should have been able to detect companions sufficiently massive to open full gaps in the disk. The structures detected at millimeter wavelengths could be gaps in the distributions of large grains on the disk midplane caused by planets not massive enough to fully open the gaps. Future ALMA observations of the molecular gas density profile and kinematics as well as higher contrast infrared observations may be able to provide a definitive answer. [less ▲]

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See detailThe Subaru Coronagraphic Extreme Adaptive Optics System: Enabling High-Contrast Imaging on Solar-System Scales
Jovanovic, N.; Martinache, F.; Guyon, O. et al

in Publications of the Astronomical Society of the Pacific (2015), 127

The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is a multipurpose high-contrast imaging platform designed for the discovery and detailed characterization of exoplanetary systems and ... [more ▼]

The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is a multipurpose high-contrast imaging platform designed for the discovery and detailed characterization of exoplanetary systems and serves as a testbed for high-contrast imaging technologies for ELTs. It is a multiband instrument which makes use of light from 600 to 2500 nm, allowing for coronagraphic direct exoplanet imaging of the inner 3λ/D from the stellar host. Wavefront sensing and control are key to the operation of SCExAO. A partial correction of low-order modes is provided by Subaru's facility adaptive optics system with the final correction, including high-order modes, implemented downstream by a combination of a visible pyramid wavefront sensor and a 2000-element deformable mirror. The well-corrected NIR (y-K bands) wavefronts can then be injected into any of the available coronagraphs, including but not limited to the phase-induced amplitude apodization and the vector vortex coronagraphs, both of which offer an inner working angle as low as 1λ/D. Noncommon path, low-order aberrations are sensed with a coronagraphic low-order wavefront sensor in the infrared (IR). Low noise, high frame rate NIR detectors allow for active speckle nulling and coherent differential imaging, while the HAWAII 2RG detector in the HiCIAO imager and/or the CHARIS integral field spectrograph (from mid-2016) can take deeper exposures and/or perform angular, spectral, and polarimetric differential imaging. Science in the visible is provided by two interferometric modules: VAMPIRES and FIRST, which enable subdiffraction limited imaging in the visible region with polarimetric and spectroscopic capabilities respectively. We describe the instrument in detail and present preliminary results both on-sky and in the laboratory. [less ▲]

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See detailSpectral Variations of Of?p Oblique Magnetic Rotator Candidates in the Magellanic Clouds
Walborn, Nolan R.; Morrell, Nidia I.; Nazé, Yaël ULg et al

in Astronomical Journal (The) (2015), 150

Optical spectroscopic monitoring has been conducted of two O stars in the SMC and one in the LMC, the spectral characteristics of which place them in the Of?p category, which has been established in the ... [more ▼]

Optical spectroscopic monitoring has been conducted of two O stars in the SMC and one in the LMC, the spectral characteristics of which place them in the Of?p category, which has been established in the Galaxy to consist of oblique magnetic rotators. All of these Magellanic stars show systematic spectral variations typical of the Of?p class, further strengthening their magnetic candidacy to the point of virtual certainty. The spectral variations are related to photometric variations derived from Optical Gravitational Lensing Experiment data by Nazé et al. in a parallel study, which yields rotational periods for two of them. Now circular spectropolarimetry is required to measure their fields, and ultraviolet spectroscopy to further characterize their low-metallicity, magnetically confined winds, in support of hydrodynamical analyses. [less ▲]

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See detailPrediction of Allogeneic Hematopoietic Stem-Cell Transplantation Mortality 100 Days After Transplantation Using a Machine Learning Algorithm: A European Group for Blood and Marrow Transplantation Acute Leukemia Working Party Retrospective Data Mining Study
SHOUVAL, Roni; LABOPIN, Myriam; BONDI, Ori et al

in Journal of Clinical Oncology (2015), 33(28), 3144-3152

Purpose: Allogeneic hematopoietic stem-cell transplantation (HSCT) is potentiallu curative for acute leukemia (AL), but carries considerable risk. Machine learning algorithms, which are part of the data ... [more ▼]

Purpose: Allogeneic hematopoietic stem-cell transplantation (HSCT) is potentiallu curative for acute leukemia (AL), but carries considerable risk. Machine learning algorithms, which are part of the data mining (DM) approach, may serve for transplantation-related mortality risk prediction. Patients and Methods: This work is a retrospective DM study on a cohort of 28,236 adult HSCT recipients from the AL registry of the European Group for Blood and Marrow Transplantation. The primary objective was prediction of overall mortality (OM) at 100 days after HSCT. Secondary objectives were estimation of nonrelapse mortality, leukemia-free survival, and overall survival at 2 years. Donor, recipient, and procedural characteristics were alalyzed. The alternating decision tree machine learning algorithm was applied for model development on 70 % of the data set and validated on the remaining data. [less ▲]

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See detailGeometrical validity of curvilinear pyramidal finite elements
Johnen, Amaury ULg; Geuzaine, Christophe ULg

in Journal of Computational Physics (2015), 299

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See detailLatex, un peu, beaucoup (9. Figures & tables)
Dupont, Pascal ULg

in Losanges (2015), 30

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See detailStructure and functioning of the Heart Team: primum non nocere.
Stefanini, Giulio G.; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2015), 48(4), 529-30

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See detailPre-return-to-work medical consultation for low back pain workers. Good practice recommendations based on systematic review and expert consensus
PETIT, Audrey; ROZENBERG, Sylvie; FASSIER, Jean-Baptiste et al

in Annals of Physical and Rehabilitation Medicine (2015), 58(5), 298-304

Objectives The pre-return-to-work medical consultation during sick leave for low back pain (LBP) aims at assessing the worker's ability to resume working without risk for his/her health, and anticipating ... [more ▼]

Objectives The pre-return-to-work medical consultation during sick leave for low back pain (LBP) aims at assessing the worker's ability to resume working without risk for his/her health, and anticipating any difficulties inherent to returning to work and job retention. This article summarizes the good practices guidelines proposed by the French Society of Occupational Medicine (SFMT) and the French National Health Authority (HAS), and published in October 2013. Methods Good practices guidelines developed by a multidisciplinary and independent task force (24 experts) and peer review committee (50 experts) based on a literature review from 1990 to 2012, according to the HAS methodology. Results According to the labour regulations, workers can request a medical consultation with their occupational physician at any time. The pre-return-to-work consultation precedes the effective return-to-work and can be requested by the employee regardless of their sick leave duration. It must be scheduled early enough to: (i) deliver reassuring information regarding risks to the lower back and managing LBP; (ii) evaluate prognostic factors of chronicity and prolonged disability in relations to LBP and its physical, social and occupational consequences in order to implement the necessary conditions for returning to work; (iii) support and promote staying at work by taking into account all medical, social and occupational aspects of the situation and ensure proper coordination between the different actors. Conclusion A better understanding of the pre-return-to-work consultation would improve collaboration and coordination of actions to facilitate resuming work and job retention for patients with LBP [less ▲]

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See detailLe coût de l'énergie verte en Wallonie 2003-2012
Boccard, Nicolas; Gautier, Axel ULg

in Reflets et Perspectives de la Vie Economique (2015), LIV(1-2), 71-85

In 2003, the Walloon region has installed a tradable green certificate mechanism to support the production of ‘green’ electricity. In this paper, we estimate that the total cost of the mechanism amounts ... [more ▼]

In 2003, the Walloon region has installed a tradable green certificate mechanism to support the production of ‘green’ electricity. In this paper, we estimate that the total cost of the mechanism amounts to 1,871 billion € for the period 2003-2012, corresponding to a support of 107 €/MWh produced, with important differences between production technologies, the solar photovoltaic receiving up to 588 €/MWh. International comparisons indicate that the Walloon mechanism is particularly generous. We also show that the induced carbon savings are extremely costly with an implicit price of avoided CO2 of 425 € per ton. [less ▲]

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See detailBrain stimulation in patients with disorders of consciousness
Thibaut, Aurore ULg; Laureys, Steven ULg

in Principles and Practice of Clinical Research (2015), 1(3),

Background and Aim: There is a long history of brain stimulation in medical science, and it was tested for years trying to treat several neurological diseases. On the other hand, the treatment choices for ... [more ▼]

Background and Aim: There is a long history of brain stimulation in medical science, and it was tested for years trying to treat several neurological diseases. On the other hand, the treatment choices for patients with severe brain injury resulting in disorders of consciousness (DOC) are still limited and research in this field remains challenging. In the current literature, only a few techniques of brain stimulation were studied in this population of patients. This review describes noninvasive techniques, namely transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), which permit to stimulate the brain through the scalp, as well as the current status of deep brain stimulation (DBS) as treatment for patients with DOC. For each technique (i.e. TMS, tDCS and DBS) a systematic search on Pubmed was performed including the term “vegetative state” or “minimally conscious state” or “disorders of consciousness” and 16 articles matched the criteria. Conclusion: Currently, repetitive TMS (rTMS) and tDCS studies have shown encouraging results, with transient improvements of behavioral signs of consciousness in patients in minimally conscious state (MCS). DBS showed more impressive and extensive behavioral improvement after the implantation of an electrical stimulator in the thalamus. However, this procedure is riskier and the number of patients who can benefit from this intervention is limited. All these therapeutic approaches are still in their infancy. In the years to follow, controlled clinical studies on potential treatments for patients with DOC should multiply and therapeutic measures should be more accessible, controlled and effective. [less ▲]

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See detailPreliminary assessment for the use of VORIS as a tool for rapid lava flow simulation at Goma Volcano Observatory, Democratic Republic of the Congo
Syavulisembo, A. M.; Havenith, Hans-Balder ULg; Smets, B et al

in Natural Hazards & Earth System Sciences (2015)

Assessment and management of volcanic risk are important scientific, economic, and political issues, especially in densely populated areas threatened by volcanoes. The Virunga volcanic province in the ... [more ▼]

Assessment and management of volcanic risk are important scientific, economic, and political issues, especially in densely populated areas threatened by volcanoes. The Virunga volcanic province in the Democratic Republic of the Congo, with over 1 million inhabitants, has to cope permanently with the threat posed by the active Nyamulagira and Nyiragongo volcanoes. During the past century, Nyamulagira erupted at intervals of 1–4 years – mostly in the form of lava flows – at least 30 times. Its summit and flank eruptions lasted for periods of a few days up to more than 2 years, and produced lava flows sometimes reaching distances of over 20 km from the volcano. Though most of the lava flows did not reach urban areas, only impacting the forests of the endangered Virunga National Park, some of them related to distal flank eruptions affected villages and roads. In order to identify a useful tool for lava flow hazard assessment at Goma Volcano Observatory (GVO), we tested VORIS 2.0.1 (Felpeto et al., 2007), a freely available software (http://www.gvb-csic.es) based on a probabilistic model that considers topography as the main parameter controlling the lava flow propagation. We tested different parameters and digital elevation models (DEM) – SRTM1, SRTM3, and ASTER GDEM – to evaluate the sensitivity of the models to changes in input parameters of VORIS 2.0.1. Simulations were tested against the known lava flows and topography from the 2010 Nyamulagira eruption. The results obtained show that VORIS 2.0.1 is a quick, easy-to-use tool for simulating lava-flow eruptions and replicates to a high degree of accuracy the eruptions tested when input parameters are appropriately chosen. In practice, these results will be used by GVO to calibrate VORIS for lava flow path forecasting during new eruptions, hence contributing to a better volcanic crisis management. [less ▲]

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See detailPhotorefractive holographic camera for monitoring deformations of MEMS
Georges, Marc ULg; Thizy, Cédric ULg

in Journal of Micro/Nanolithography, MEMS, and MOEMS (2015), 14(4), 041301

We present the development of a holographic interferometer based on dynamic hologram recording with photorefractive crystals of the sillenite family and which is adapted for the observation of MEMS. A ... [more ▼]

We present the development of a holographic interferometer based on dynamic hologram recording with photorefractive crystals of the sillenite family and which is adapted for the observation of MEMS. A compact portable system was already presented in the past and used in various metrology and nondestructive applications on large scattering objects. It was emphasized the great versatility of the instrument which allows high resolution measurements. Here we show the development and achievement of an optical module which can be easily interfaced on the basic instrument, allowing small specular objects observation. Results of deformation of electrically actuated MEMS are shown. [less ▲]

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See detailMarchés énergétiques en transition : le cas de la Belgique
Agrell, Per; Gautier, Axel ULg

in Reflets et Perspectives de la Vie Economique (2015), LIV(1-2), 5-6

Foreword by Per Agrell and Axel Gautier

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See detailLymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.
Fernandes, Monica T.; Ghezzo, Marinella N.; Silveira, Andre B. et al

in British journal of haematology (2015)

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we ... [more ▼]

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we show that the genes encoding lymphotoxin (LT)-alpha and LTbeta (LTA, LTB) are expressed in T-ALL patient samples, mostly of the TAL/LMO molecular subtype, and in the TEL-JAK2 transgenic mouse model of cortical/mature T-ALL (Lta, Ltb). In these mice, expression of Lta and Ltb is elevated in early stage T-ALL. Surface LTalpha1 beta2 protein is expressed in primary mouse T-ALL cells, but only in the absence of microenvironmental LTbetaR interaction. Indeed, surface LT expression is suppressed in leukaemic cells contacting Ltbr-expressing but not Ltbr-deficient stromal cells, both in vitro and in vivo, thus indicating that dynamic surface LT expression in leukaemic cells depends on interaction with its receptor. Supporting the notion that LT signalling plays a role in T-ALL, inactivation of Ltbr results in a significant delay in TEL-JAK2-induced leukaemia onset. Moreover, young asymptomatic TEL-JAK2;Ltbr-/- mice present markedly less leukaemic thymocytes than age-matched TEL-JAK2;Ltbr+/+ mice and interference with LTbetaR function at this early stage delayed T-ALL development. We conclude that LT expression by T-ALL cells activates LTbetaR signalling in thymic stromal cells, thus promoting leukaemogenesis. [less ▲]

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See detailLes Mots des Maths : Trapèze
Dupont, Pascal ULg

in Losanges (2015), 30

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See detailAnalyse exploratoire des liens entre l’interaction entraîneur-joueuses, les représentaitons mutuelles de l’entraînement et la performance sportive
Rémy, Elodie; Manfredini, Tiber ULg; Cloes, Marc ULg

in Bulletin de Psychologie (2015), 68(5), 355-366

The coach-athlete relationship is well documented in the literature. Based on an original research model, the study is focused on three female basketball clubs of the 1st regional division in Wallonia ... [more ▼]

The coach-athlete relationship is well documented in the literature. Based on an original research model, the study is focused on three female basketball clubs of the 1st regional division in Wallonia. Combining interviews, participant observation, focus groups, and perception questionnaires, it appears that the relational dynamics of the three sites differs considerably: ‘Back to back’, ‘Above-below’, ‘Inside’. In each case, the coach-players relationship does not seem suitable to the optimal use of the available resources, in order to reach a sport performance in agreement. Courses of actions are suggested for provoking some improvement of the situations. [less ▲]

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See detailPropriété coopérative et acceptabilité sociale de l’éolien terrestre
Bauwens, Thomas ULg

in Reflets et Perspectives de la Vie Economique (2015), LIV(1-2), 59-70

Onshore wind power development in Belgium has provoked considerable opposition at the local level. To cope with this issue, wind power cooperatives seem to present important assets. This article explores ... [more ▼]

Onshore wind power development in Belgium has provoked considerable opposition at the local level. To cope with this issue, wind power cooperatives seem to present important assets. This article explores the reasons why these organizations are likely to enhance social acceptability of this technology. Then it confronts these normative assumptions with empirical data. The results of this analysis confirm the positive effect of cooperative ownership on the social acceptability of onshore wind turbines. [less ▲]

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See detailLes souvenirs définissant le soi dans le trouble dépressif majeur unipolaire : Pourquoi les évoquer durant l’entretien clinique ?
Wagener, Aurélie ULg; Boulanger, Marie ULg; PITCHOT, William ULg et al

in Acta Psychiatrica Belgica (2015), 116(2), 27-34

Unipolar depressed patients can experience a loss of sense of self-continuity. Self-defining memories which are particular autobiographical memories may consist in psychological interventions aiming at ... [more ▼]

Unipolar depressed patients can experience a loss of sense of self-continuity. Self-defining memories which are particular autobiographical memories may consist in psychological interventions aiming at reestablishing the sense of self-continuity. Working on self-defining memories may also help dealing with other psychological difficulties. This article presents the self-defining memories, their characteristics and different psychological interventions which aim is to enhance the quality of these memories. [less ▲]

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See detailDésobéissance et non-respect des normes juridiques
Garcia Villegas, Mauricio; Lejeune, Aude ULg

in Droit et Société (2015), 91

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See detailPrise en charge des patients lombalgiques : les mots du thérapeute aussi importants que ses mains
Demoulin, Christophe ULg; Roussel, Nathalie; Marty, M. et al

in Axxon Exclusif (2015)

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See detailL’ÉTUDE CLINIQUE DU MOIS TECOS : confirmation de la sécurité cardiovasculaire de la sitagliptine
SCHEEN, André ULg; PAQUOT, Nicolas ULg

in Revue Médicale de Liège (2015), 70

Summary : The cardiovascular safety of sitagliptin has been evaluated in TECOS («Trial Evaluating Cardiovascular Outcomes with Sitagliptin»). TECOS recruited patients with type 2 diabetes and a history of ... [more ▼]

Summary : The cardiovascular safety of sitagliptin has been evaluated in TECOS («Trial Evaluating Cardiovascular Outcomes with Sitagliptin»). TECOS recruited patients with type 2 diabetes and a history of cardiovascular disease who received, as add-on to their usual therapy, either sitagliptin (n = 7.257) or placebo (n = 7.266), with a median follow-up of 3 years. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95 % confidence interval, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95 % CI, 0.83 to 1.20; P=0.98). The cardiovascular safety of sitagliptin, which was already shown in meta-analyses of phase II-III randomised controlled trials and in observational cohort studies in real life, is now confirmed in the landmark prospective cardiovascular outcome study TECOS. [less ▲]

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See detailHeritability of milk fat composition is considerably lower for Meuse-Rhine-Yssel compared to Holstein Friesian cattle
Maurice-Van Eijndhoven, Myrthe; Veerkamp, Roel; Soyeurt, Hélène ULg et al

in Livestock Science (2015), 180

The aim of this paper is to identify differences in genetic variation of fatty acid (FA) composition in milk in different breeds. Data used included Meuse-Rhine-Yssel (MRY) and Holstein Friesian (HF ... [more ▼]

The aim of this paper is to identify differences in genetic variation of fatty acid (FA) composition in milk in different breeds. Data used included Meuse-Rhine-Yssel (MRY) and Holstein Friesian (HF) cattle breeds which were raised in the Netherlands. Both populations participated in the same milk recording system, but differed in selection history, where in the MRY there has been relatively very little emphasis on selection for high-input high-output production systems compared to HF. Differences in genetic variation were investigated by estimating breed specific additive genetic variances and heritabilities for FA contents in milk of MRY and HF. Mid Infrared Spectrometry spectra were used to predict total fat percentage and detailed FA contents in milk (14 individual FA and 14 groups of FA in g of fat/dL of milk). The dataset for MRY contained 2916 records from 2049 registered cows having at least 50% genes of MRY origin and the dataset used for HF contained 155,319 records from 96,315 registered cows having at least 50% genes of HF origin. Variance components of individual FA content in milk for the different breeds were estimated using a single trait animal model. Additive genetic variances for FA produced through de novo synthesis (short chain FA, C12:0, C14:0, and partly C16:0), C14:1 c-9 and C16:1 c-9 were significantly higher (. P<0.001) for HF compared to MRY. Heritabilities of the individual FA, C4:0 to C18:0, for HF ranged from 0.28 to 0.52 and for MRY from 0.17 to 0.34. Heritabilities of the individual C18 unsaturated FA for HF ranged from 0.11 to 0.34 and for MRY from 0.10 to 0.26. Although the mean content in milk for the FA C18:2 c-9, t-11 was low in both breeds, the additive genetic variance in our dataset was significantly higher for MRY (P<0.05) compared to HF. Heritabilities of the groups of FA for HF ranged from 0.19 to 0.53 and for MRY from 0.11 to 0.28. For the majority of the FA, the additive genetic variances for HF were significantly higher compared to MRY, except for most of the poly-unsaturated FA. The results for the poly-unsaturated FA, however, may be affected by the lower accuracy of the predictions for these FA. In conclusion, our results show that the HF breed has substantially larger genetic variance for most FA compared to MRY. © 2015 Elsevier B.V. [less ▲]

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See detailComment je traite... la reconstruction du nez
RENWART, Ludovic ULg; NIZET, Jean-Luc ULg

in Revue Médicale de Liège (2015), 70(10), 481-485

Les pertes de substance sont une pathologie fréquente en chirurgie plastique, principalement après l'exérèse de cancer de la peau. Les résultats de la reconstruction nasale doivent répondre à des ... [more ▼]

Les pertes de substance sont une pathologie fréquente en chirurgie plastique, principalement après l'exérèse de cancer de la peau. Les résultats de la reconstruction nasale doivent répondre à des exigences esthétiques et fonctionnelles élevées. Une analyse minutieuse de la perte de substance est impérative pour évaluer les déficits anatomiques et esthétiques. Toute perte osseuse, cartilagineuse ou de la muqueuse doit être restaurée. Les lambeaux locaux permettent de couvrir les pertes de substances limitées. Le lambeau frontal est le lambeau de référence pour les plaies complexes. [less ▲]

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See detailGlobal capacity announcement of electrical distribution systems: A pragmatic approach
Cornélusse, Bertrand ULg; Vangulick, David; Glavic, Mevludin ULg et al

in Sustainable Energy, Grids and Networks (2015), 4

We propose a pragmatic procedure to facilitate the connection process of Distributed Generation (DG) with reference to the European regulatory framework where Distribution System Operators (DSOs) are ... [more ▼]

We propose a pragmatic procedure to facilitate the connection process of Distributed Generation (DG) with reference to the European regulatory framework where Distribution System Operators (DSOs) are, except in specific cases, not allowed to own their generation. The procedure is termed Global Capacity ANnouncement (GCAN) and is intended to compute the estimates of maximum generation connection amount at appropriate substations in a distribution system, to help generation connection decisions. The pragmatism of the proposed procedure stems from its reliance on the tools that are routinely used in distribution systems planning and operation, and their use such that the possibilities of network sterilization are avoided. The tools involved include: long-term load forecasting, long-term planning of network extension/reinforcement, network reconfiguration, and power flow. Network sterilizing substations are identified through repeated power flow computations. The proposed procedure is supported by results using an artificially created 5-bus test system, the IEEE 33-bus test system, and a part of real-life distribution system of ORES (a Belgian DSO serving a large portion of the Walloon region in Belgium). [less ▲]

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