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See detailHistologically Proven Bronchial Neuroendocrine Tumors in MEN1: A GTE 51-Case Cohort Study.
Lecomte, Pierre ULiege; Binquet, C.; Le Bras, M. et al

in World Journal of Surgery (2017)

OBJECTIVE: To evaluate the natural history of MEN1-related bronchial endocrine tumors (br-NETs) and to determine their histological characteristics, survival and causes of death. br-NETs frequency ranges ... [more ▼]

OBJECTIVE: To evaluate the natural history of MEN1-related bronchial endocrine tumors (br-NETs) and to determine their histological characteristics, survival and causes of death. br-NETs frequency ranges from 3 to 13% and may reach 32% depending on the number of patients evaluated and on the criteria required for diagnosis. METHODS: The 1023-patient series of symptomatic MEN1 patients followed up in a median of 48.7 [35.5-59.6] years by the Groupe d'etude des Tumeurs Endocrines was analyzed using time-to-event techniques. RESULTS: br-NETs were found in 51 patients (4.8%, [95% CI 3.6-6.2%]) and were discovered by imaging in 86% of cases (CT scan, Octreoscan, Chest X-ray, MRI). Median age at diagnosis was 45 years [28-66]. Histological examination showed 27 (53%) typical carcinoids (TC), 16 (31%) atypical carcinoids (AC), 2 (4%) large cell neuroendocrine carcinomas (LCNEC), 3(6%) small cell neuroendocrine carcinomas (SCLC), 3(6%) TC associated with AC. Overall survival was not different from the rest of the cohort (HR 0.29, [95% CI 0.02-5.14]). AC tended to have a worse prognosis than TC (p = 0.08). Seven deaths were directly related to br-NETs (three AC, three SCLC and one LCNEC). Patients who underwent surgery survived longer (p = 10-4) and were metastasis free, while 8 of 14 non-operated patients were metastatic. There were no operative deaths. CONCLUSIONS: Around 5% of MEN1 patients develop br-NETs. br-NETs do not decrease overall survival in MEN1 patients, but poorly differentiated and aggressive br-NETs can cause death. br-NETs must be screened carefully. A biopsy is essential to operate on patients in time. [less ▲]

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See detailIncreased expression of bacterial amoA during an N2O emission peak in an agricultural field
Theodorakopoulos, Nicolas ULiege; Lognoul, Margaux ULiege; Degrune, Florine ULiege et al

in Agriculture, Ecosystems & Environment (2017), 236

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak ... [more ▼]

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak on a maize crop after a natural rainfall. The peak occurred rapidly after the rainfall began. Spatial and temporal variability in N2O emission was observed between chambers. An analysis of N-cycle gene transcript levels revealed an increase in bacterial amoA gene transcripts (but not in archaeal amoA transcripts), correlating strongly with N2O emission. This suggests the involvement of nitrification enzymes, despite a high water-filled pore space (80%). Reverse transcription of bacterial 16S rRNA followed by partial sequencing of the resulting cDNAs revealed few rainfall-induced changes in the potentially active bacterial community, and notably no significant change in the relative abundance of 16S rRNAs from the nitrifier genus Nitrosospira. Expression of the amoA gene appears as a possible proxy for monitoring the N2O emission peak. To our knowledge, this is the first experiment to evaluate the expression of N-cycle genes during an N2O emission peak on an agricultural field. [less ▲]

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See detailDétection de l’érosion dans un bassin versant agricole par comparaison d’images multidates acquises par drone
Lisein, Jonahtan; Pineux, Nathalie; Pierrot-Deseilligny, Marc et al

in Revue française de Photogrammétrie et de Télédétection (2017), 213-214(janvier-avril), 133-141

L’émergence des drones comme outils de cartographie rapide, de par leur capacité à répondre à des besoins très spécifiques, offre de nombreuses opportunités aux scientifiques. Par ailleurs, les récentes ... [more ▼]

L’émergence des drones comme outils de cartographie rapide, de par leur capacité à répondre à des besoins très spécifiques, offre de nombreuses opportunités aux scientifiques. Par ailleurs, les récentes évolutions des techniques de photogrammétrie et de vision par ordinateur permettent, à partir de prises de vues aériennes stéréoscopiques, de fournir aux géomorphologues et aux hydrologues des données topographiques à haute résolution (Tarolli, 2014). En effet, les algorithmes d’orientation externe (structure from motion en anglais, Snavely et al. (2008)) permettent la détermination automatique de la position et de l’orientation des prises de vue d’une collection d’images se recouvrant. La corrélation dense automatique permet ensuite, depuis un bloc d’images orientées, de modéliser finement le relief. L’utilisation en géomorphologie de drones pour la modélisation du relief en est encore à ses premiers souffles, mais montre un potentiel très intéressant. La précision des mesures photogrammétriques rivalise en effet avec les relevés LiDAR, pour un coût d’acquisition significativement moins élevé. Cette recherche se focalise sur deux objectifs. Le premier est de déterminer si la précision des mesures photogrammétriques issues d’images acquises avec un mini-drone permet la détection de changement de relief très fin via la comparaison d’acquisitions multi-dates. Le deuxième objectif, plus spécifique, est de déterminer la manière la plus optimale de paramétrer la compensation par faisceaux avec points d’appui au sein de la suite photogrammétrique open-source MICMAC. [less ▲]

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See detailLa mise en œuvre du droit de plainte en Belgique francophone. Observation des processus de médiation en soins de santé
Dubois, Christophe ULiege; Vandeninden, Elise ULiege

in Revue Française des Affaires Sociales (2017), 1(1), 79-96

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the ... [more ▼]

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the application of this right of complaint. What happens to a patient’s complaint? This is the question that this article attempts to answer through a report on the “local” organization of mediation ser‐ vices within the hospital. It thus clari es the links and divergences between the formal discourses accompanying the implementation of the mediation function in health care on the one hand, and, on the other hand, the actual practices of media‐ tion determined by the work of mediators in the hospital. [less ▲]

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See detailThe Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission.
Zeippen, Caroline ULiege; Javaux, Justine; Xiao, Xue ULiege et al

in Journal of Virology (2017), 91(13),

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a ... [more ▼]

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and in vitro, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection but is poorly released from vaginal epithelial cells and fails to pass from the female to the male genital tract during sexual contact. Thus, we show that the regulation of virion binding is a key component of spontaneous gammaherpesvirus transmission.IMPORTANCE Gammaherpesviruses are responsible for many important diseases in both animals and humans. Some important aspects of their life cycle are still poorly understood. Key among these is viral transmission. Here we show that the major envelope glycoprotein of murid herpesvirus 4 functions not in entry or dissemination but in virion release to allow sexual transmission to new hosts. [less ▲]

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See detailMiddle Ordovician cryptospores from the Saq-Hanadir transitional beds in the QSIM-801 well, Saudi Arabia
Vecoli, M.; Wellman, C.H.; Gerrienne, Philippe ULiege et al

in Revue de Micropaléontologie (2017), 60

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See detailMetals as chemical tracers to discriminate ecological populations of threatened Franciscana dolphins (Pontoporia blainvillei) from Argentina
Romero, M.B.; Polizzi, P.; Chiodi, L. et al

in Environmental Science and Pollution Research (2017), 24(4), 3940-3950

Franciscana dolphins are the most impacted small cetacean in the Southwestern Atlantic Ocean, classified as Vulnerable A3d by IUCN. Essential (Fe, Mo, Mn, Cr, Ni, Co) and non-essential (Ag, Pb, Sn) trace ... [more ▼]

Franciscana dolphins are the most impacted small cetacean in the Southwestern Atlantic Ocean, classified as Vulnerable A3d by IUCN. Essential (Fe, Mo, Mn, Cr, Ni, Co) and non-essential (Ag, Pb, Sn) trace elements (TEs) were measured in liver, kidney, and brain samples of by-catch Franciscana dolphins that were living in estuarine (n = 21) and marine (n = 21) habitats (1) to assess whether TEs posed a threat and (2) to evaluate the suitability of TEs for discriminating ecological populations of this species in Argentinean waters. Essential TEs showed little variation in tissues from both groups in agreement with levels reported for other cetaceans and suggesting that these concentrations correspond to normal physiological levels. Non-essential TEs were higher in estuarine juveniles and adults dolphins than in marine specimens. These results suggest anthropogenic sources associated with estuarine area and that Franciscana dolphins are good sentinels of the impact of the environment. The difference in the concentrations of TEs beetwen ecological populations appeared to be related to distinct exposures in both geographical areas, and it is suggested that Ag and Sn concentrations in adults are good chemical tracers of anthropogenic input of TEs. These results provide additional information for improved management and regulatory policy. [less ▲]

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See detailLegal Mobilization Within the Bureaucracy: Disability Rights and the Implementation of Antidiscrimination Law in Sweden
Lejeune, Aude ULiege

in Law and Policy (2017)

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social ... [more ▼]

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social movements' demands or is a field of contention for those demands. Focusing on how disability bureaucrats and activists mobilize antidiscrimination law in Sweden, this article shows that two main factors shape legal mobilization within the bureaucracy and alter the state's ability to become a legal mobilization actor: (1) the institutional relationships between social movement organizations and government agencies; and (2) the profiles and careers of bureaucrats and activists. It concludes by suggesting several lines for further research on law and social movements in nonpluralist countries. [less ▲]

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See detailAn investigation on the use of coarse volcanic scoria as sand in Portland cement mortar
Juimo Tchamdjou, Willy Hermann; Grigoletto, Sophie ULiege; Michel, Frédéric ULiege et al

in Case studies in Building Materials (2017), 7

In this study, the utilization of coarse volcanic scoria CVS as sand in Portland cement mortar was investigated. The aim of this study is to give some physical properties, mechanical properties and ... [more ▼]

In this study, the utilization of coarse volcanic scoria CVS as sand in Portland cement mortar was investigated. The aim of this study is to give some physical properties, mechanical properties and durability properties of CVS mortars investigated at short term of curing in comparison with a reference mortar. Investigation was carried out on three groups of mortar samples according to the proportion of fine particles on the coarse volcanic scoria, “low” for the first group MCVS1, “average” for the second group MCVS2 and “high” for the third group MCVS3. The reference mortar has been made with standard sand. The water–cement w/c ratio and sand/cement s/c ratio used in the mixtures were 0.5 and 3, respectively according to European Standard EN 196-1- 2005. The particle size of CVS aggregates used to prepare mortar mixtures were between 0.08 mm and 2.00 mm like in the standard sand. Compressive and flexural strengths were tested at mortar age of 28 days. The results revealed improved compressive and flexural strengths, which were maximal for the MCVS3 samples. Unit weight increased with the ratio of fine CVS size between 0.08–1.00 mm. Sorptivity and carbonation depth decrease as the ratio of fine CVS increase. Based on these results, using Cameroonian volcanic scoria in the appropriate particles size ratio composition will improve these mortar characteristics. CVS mortars can be used for more applications for building construction in Cameroon and all over the world, especially in regions where volcanic scoria resources are abundant. [less ▲]

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See detailA new Late Devonian isoetalean lycopsid from New South Wales, Australia: Cymastrobus irvingii gen. et sp. nov.
Evreïnoff, M.; Meyer-Berthaud, B.; Decombeix, A.-L. et al

in Palaeontologia Electronica (2017), 20.3.45A

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See detailTowards a life of poverty and uncertainty? The livelihood strategies of Gécamines workers after retrenchment in the DRC
Rubbers, Benjamin ULiege

in Review of African Political Economy (2017), 44 (152)

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See detailIsotopic niches of Fin Whales from the Mediterranean Sea and the Celtic sea (North Atlantic)
Das, Krishna ULiege; Holleville, Ophélie; Ryan, Conor et al

in Marine Environmental Research (2017), 127

The fin whale (Balaenoptera physalus) is the most abundant and widespread mysticete species in the Mediterranean Sea, found mostly over deep, offshore waters of the western and central portion of the ... [more ▼]

The fin whale (Balaenoptera physalus) is the most abundant and widespread mysticete species in the Mediterranean Sea, found mostly over deep, offshore waters of the western and central portion of the region. In the Mediterranean, this species is known to feed mainly on krill, in contrast to its Atlantic counterpart, which displays a more diversified diet. The International Whaling Commission recognizes several managements units in the Atlantic and the Mediterranean Sea and the connectivity between these populations is still being debated. Questions remain about inter-individual feeding strategies and trophic ecology. The goal of this study was to compare isotopic niches of fin whales from the Mediterranean Sea and the Celtic Sea (North Atlantic). δ13C and δ15N values were analysed in 136 skin biopsies from free-ranging Mediterranean fin whales sampled in 2010 and 2011 during campaigns at sea. δ13C and δ15N values ranged from -20.4 to -17.1 ‰ and from 5.9 to 8.9 ‰, respectively. These values are in good agreement with those estimated previously from baleen plates from Mediterranean and North Atlantic fin whales. The narrow isotopic niche width of the Mediterranean fin whale (Standard Ellipses area SEAc) compared to the North Atlantic fin whale raises many concerns in the context of global changes and long-term consequences. One could indeed expect that species displaying narrow niches would be more susceptible to ecosystem fragmentation and other anthropogenic impacts. [less ▲]

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See detailMisrecollection prevents older adults from benefitting from semantic relatedness of the memoranda in associative memory
Delhaye, Emma ULiege; Tibon, Roni; Gronau, Nurit et al

in Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition (2017)

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See detailProteomic profile of aphids exposed to wheat with different contents of benzoxazinoids
Barrios–San Martín, Joceline; Bosquée, Emilie ULiege; Rubio-Melendez, Maria et al

in Physiological Entomology (2017), Accepted

Benzoxazinoids are key defence chemicals in cereals that are known to affect several aspects of aphid biology. However, little is known about how they affect aphid physiology. In this study, we report ... [more ▼]

Benzoxazinoids are key defence chemicals in cereals that are known to affect several aspects of aphid biology. However, little is known about how they affect aphid physiology. In this study, we report changes in the whole-body proteomic profiles of a DIMBOA-susceptible genotype of the grain aphid Sitobion avenae (F.) after being exposed to wheat cultivars containing contrasting levels of DIMBOA. The proteome was analysed after 14 (short term) and 28 days (long term) of rearing on these cultivars. Seventy-two proteins were differentially regulated among the treatments, and 49 were identified. Exposure to high-DIMBOA plants resulted in a higher number of proteins regulated long term. DIMBOA exposure in S. avenae initially generated greater cellular activities, mostly involving cytoskeleton function and possibly related to detoxification. This function appeared to be unimportant at long term and was eventually replaced by effects on metabolism function and homeostasis. Taken together, the result shows that aphids’ responses to the secondary plant compounds, such as DIMBOA, exhibit a temporal dynamic in the proteome, possibly helping aphids to overcome the effect of these toxic compounds. [less ▲]

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See detailFenomenologische psychopathologie : Hedendaagse inbreng en uitdagingen van morgen
Englebert, Jérôme ULiege

in Neurone (2017), 22(9), 1-5

Dit artikel beschrijft de geschiedenis van de fenomenologische psychopathologie, die ondertussen honderd jaar bestaat, en vat de bijdrage van de fenomenologie aan de psychopathologie samen. Enerzijds gaat ... [more ▼]

Dit artikel beschrijft de geschiedenis van de fenomenologische psychopathologie, die ondertussen honderd jaar bestaat, en vat de bijdrage van de fenomenologie aan de psychopathologie samen. Enerzijds gaat dit artikel over een recente bijdrage die de fenomenologische psychopathologie heeft geleverd aan de kennis over een geestesziekte waar we niet omheen kunnen: schizofrenie. Anderzijds belichten we de uitdagingen, perspectieven en projecten die deze heroplevende discipline kennelijk met zich meebrengt. [less ▲]

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See detailDifferential interaction of synthetic glycolipids with biomimetic plasma membrane lipids correlates with plant biological response
Nasir, Mehmet Nail ULiege; Lins, Laurence ULiege; Crowet, Jean-Marc ULiege et al

in Langmuir (2017)

Natural and synthetic amphiphilic molecules including lipopeptides, lipopolysaccharides and glycolipids are able to induce defense mechanisms in plants. In the present work, the perception of two ... [more ▼]

Natural and synthetic amphiphilic molecules including lipopeptides, lipopolysaccharides and glycolipids are able to induce defense mechanisms in plants. In the present work, the perception of two synthetic C14 rhamnolipids, namely Alk-RL and Ac-RL, differing only at the level of the lipid tail terminal group, have been investigated using biological and biophysical approaches. We showed that Alk-RL induces a stronger early signaling response in tobacco cell suspensions than does Ac-RL. The interactions of both synthetic RLs with simplified biomimetic membranes were further analyzed using experimental and in silico approaches. Our results indicate that the interactions of Alk-RL and Ac-RL with lipids were different in terms of insertion and molecular responses and were dependent on the lipid composition of model membranes. A more favorable insertion of Alk-RL than Ac-RL into lipid membranes is observed. Alk-RL forms more stable molecular assemblies than Ac-RL with phospholipids and sterols. At the molecular level, the presence of sterols tends to increase the RLs’ interaction with lipid bilayers with a fluidizing effect on the alkyl chains. Taken together, our findings suggest that the perception of these synthetic RLs at the membrane level could be related to a lipid-driven process depending on the organization of the membrane and the orientation of the RLs within the membrane and is correlated with the induction of early signaling responses in tobacco cells. [less ▲]

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See detailExperimental observation of the Poincaré-Birkhoff scenario in a driven many-body quantum system
Tomkovic, Jiri; Muessel, Wolfgang; Strobel, Helmut et al

in Physical Review A (2017), 95

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See detailRe: Prediction of delivery time in second stage of labor using transperineal ultrasound.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017), 49(5), 663-664

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See detailTopography and Lateralized Effect of Acute Aromatase Inhibition on Auditory Processing in a Seasonal Songbird
de groof, Geert; Balthazart, Jacques ULiege; Cornil, Charlotte ULiege et al

in Journal of Neuroscience (2017), 37(16), 4243-4254

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of ... [more ▼]

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of estrogens on nuclear receptors. One of the best examples of such neuro- modulation by neuroestrogens concerns the acute regulation of sensory coding by the auditory cortex as demonstrated by electrophys- iological studies of selected neurons in zebra finches. Yet, the spatial extent of such modulation by neuroestrogens is not known. Using functional magnetic resonance imaging, we demonstrate here that acute estrogen depletion alters within minutes auditory processing in male European starlings. These effects are confined to very specific but large areas of the auditory cortex. They are also specifically lateralized to the left hemisphere. Interestingly, the modulation of auditory responses by estrogens was much larger (both in amplitude and in topography) in March than in December or May/June. This effect was presumably independent from changes in circulating testosterone concentrations since levels of the steroid were controlled by subcutaneous implants, thus suggesting actions related to other aspects of the seasonal cycle or photoperiodic manipulations. Finally, we also show that estrogen production specifically modulates selectivity for behaviorally relevant vocalizations in a specific part of the caudomedial nidopallium. These findings confirm and extend previous conclusions that had been obtained by electrophysiological techniques. This approach provides a new very powerful tool to investigate auditory responsiveness in songbirds and its fast modulation by sex steroids. [less ▲]

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See detailCarbon, Nitrogen and Sulphur isotopic fractionation in captive juvenile hooded seal (Cystophora cristata): application for diet analysis
Pinzone, Marianna ULiege; Acquarone, Mario; Huyghebaert, Loreen ULiege et al

in Rapid Communications in Mass Spectrometry (2017)

Rationale: Intrinsic biogeochemical markers, such as stable isotope ratios of carbon, nitrogen and sulphur are increasingly used to trace the trophic ecology of marine top predators. However, insufficient ... [more ▼]

Rationale: Intrinsic biogeochemical markers, such as stable isotope ratios of carbon, nitrogen and sulphur are increasingly used to trace the trophic ecology of marine top predators. However, insufficient knowledge of fractionation processes in tissues continues to hamper the use of these markers.Methods: We performed a controlled feeding experiment with eight juvenile hooded seals (Cystophora cristata) that were held on a herring-based diet (Clupea harengus) for two years. Stable isotope ratios were measured via isotope ratio mass spectrometry in three of their tissues and related to values of these markers in their diet. Results: Diet-tissue isotope enrichment (trophic enrichment factor, TEF) values between dietary herring and seal tissues for carbon (Δ13C) were + 0.7 ‰ for red blood cells, + 1.9 ‰ for hair and + 1.1 ‰ for muscle. The TEFs for nitrogen trophic (Δ15N) were + 3.3 ‰ for red blood cells, + 3.6 ‰ for hair and + 4.3 ‰ for muscle. For sulphur, the Δ34S values were +1.1 ‰ for red blood cells, + 1.0 ‰ for hair and + 0.9 ‰ for muscle.Conclusions: These enrichment values were greater than those previously measured in adult seals. This increase may be related to the higher rate of protein synthesis and catabolism in growing animals. This study is the first report on sulphur isotope enrichment values for a marine mammal species. [less ▲]

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See detailLa collaboration entre architectes et plasticiens à Liège dans les années 1930.
Charlier, Sébastien ULiege

in In Situ : Revue des Patrimoines (2017), 32(2017),

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales ... [more ▼]

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales, le mensuel revendique une vision transversale de l’architecture où la réflexion plastique occupe une place centrale. Dès le départ, elle s’associe à Anthologie, revue imprégnée des théories futuristes et qui diffuse les artistes de l’avant-garde locale. D’abord par le biais de l’édition et des expositions, plasticiens et architectes travaillent ensuite ensemble dans le cadre de projets ambitieux financés par les pouvoirs publics. Cette contribution revient aux racines de cette collaboration en définissant les liens théoriques ou personnels unissant les deux revues. En se concentrant sur les infrastructures publiques, elle comment les artistes et les architectes ont répondu ensemble aux exigences concrètes de la commande en les replaçant dans le contexte social, politique et économique d’une ville belge de seconde importance à la veille de la Seconde Guerre mondiale. [less ▲]

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See detailEffects of the conversion of intensive grasslands into Christmas tree plantations on bird assemblages
Gailly, Robin ULiege; Paquet, Jean-Yves; Titeux, Nicolas et al

in Agriculture, Ecosystems & Environment (2017), 247

Over the last decade, the conversion of annual-rotation based crops or grassland areas into non-food perennial crops has been increasingly prevalent in European farming systems. This shift is associated ... [more ▼]

Over the last decade, the conversion of annual-rotation based crops or grassland areas into non-food perennial crops has been increasingly prevalent in European farming systems. This shift is associated with major changes in management practices and has created new environmental conditions and resources for wildlife. Impacts on birds have been examined for bioenergy agricultural systems, such as miscanthus plantations and short-rotation willow coppice. However, they remain largely unknown for Christmas tree plantations (CTPs) that have recently increased considerably in some European countries. We examined the extent to which CTPs alter bird species assemblages in the farmland areas of southern Belgium, where they mainly replace intensive grassland. The abundance of birds was recorded during the breeding season in randomly selected sites located in grassland and in CTP. Results show that introduction of CTP into landscapes dominated by grassland with low hedge densities locally increases bird species richness and abundance without leading to biotic homogenization. Differences in species richness and abundance between grassland and CTP decrease with increasing hedge densities. A community analysis indicates that the plantation of Christmas trees enriches the bird assemblage of intensive grassland areas. In intensive grassland with few hedges, small-size CTPs could constitute an option to increase structural heterogeneity and provide new potential breeding conditions for some farmland birds. However, questions remain about the genuine quality of the resources available in CTP and further research is needed to examine the breeding success and survival of birds that settle in this type of habitat. [less ▲]

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See detailAntimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica
Ledoux, Allison ULiege; St-Gelais, Alexis; Cieckiewicz, Ewa ULiege et al

in Journal of Natural Products (2017), 80(6), 1750-1757

Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1−3, and named Poupartone A−C. The ... [more ▼]

Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1−3, and named Poupartone A−C. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data analysis and MS, whereas calculated and experimental ECD spectra were used to define the absolute configurations. These compounds were active against 3D7 and W2 Plasmodium falciparum strains with IC50 values between 0.55 and 1.81 μM. In vitro cytotoxicity against WI38 human fibroblasts and the human cervical cancer cell line HeLa (WST-1 assay) showed that these compounds were also cytotoxic, but no hemolytic activity was observed for the extract and pure compounds. An in vivo antimalarial assay was performed on the major cyclohexenone using P. berghei-infected mice at a dose of 15 mg/kg/day ip. The assay revealed growth inhibition of 59.1 and 69.5% at days 5 and 7 postinfection, respectively, although some toxicity was observed. Zebrafish larvae were used as a model to determine the type of toxicity, and the results showed cardiac toxicity. The methanol extract was also studied, and it displayed moderate antiplasmodial properties in vitro. This extract contained the known flavonoids, quercetin, 3′-O-hydroxysulfonylquercetin, quercitrin, and isoquercitrin as well as ellagic acid, which showed high to low activity against the 3D7 P. falciparum strain. [less ▲]

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See detailRoad and intermodal transport performance: the impact of operational costs and air pollution external costs
Mostert, Martine ULiege; Caris, An; Limbourg, Sabine ULiege

in Research in Transportation Business & Management (2017)

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that ... [more ▼]

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that are not necessarily taken into account in public transportation policies and in private transportation decisions of companies and individuals. This leads to inefficient transportation systems where the social equilibrium is not reached. Intermodal transport is promoted by the European Commission to reduce these negative externalities. The objective of this paper is to analyze at a strategic level the effect on modal split between road, intermodal rail and intermodal inland waterway transport of several economic or environmental policies. An intermodal allocation model is applied to the Belgian case in order to identify the modal split changes between the single minimization of costs (operational or health-related external) and the introduction of additional road taxes. [less ▲]

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See detailReference values of two-dimensional and M-mode echocardiographic measurements as a function of body size in various equine breeds and in ponies.
Al-Haidar, Ali; Moula, Nassim ULiege; Leroux, Aurélia ULiege et al

in Journal of Veterinary Cardiology : The Official Journal of the European Society of Veterinary Cardiology (2017)

Introduction: The aim of this study was to establish echocardiographic reference values for the equine species using allometric regression equations based on body weight (BW) and thoracic circumference ... [more ▼]

Introduction: The aim of this study was to establish echocardiographic reference values for the equine species using allometric regression equations based on body weight (BW) and thoracic circumference (TC). Animals: A total of 239 horses or ponies were studied, including 65 warmbloods, 33 Standardbreds, 41 Thoroughbreds, 32 Arabian horses, 28 draft horses and 40 ponies aged from 1 day to 30 years, weighing from 18 to 890 kg, with no evidence of cardiac disease. Methods: For each horse or pony, a two-dimensional and M-mode echocardiography was performed. Within each breed, the relationships between BW or TC and echocardiographic dimensions were examined using power regression equations. Predictions and their 95% prediction intervals were calculated for the echocardiographic measurements. Results: Within each breed, all echocardiographic measurements showed a significant and positive relationship with a high coefficient of determination for the estimation of the regression equations using BW and TC as the main explanatory variables. Breed-specific power regression equations as well as the 95% prediction intervals were calculated for each echocardiographic measurement as a function of BW and TC. Conclusions: In the future, the body size-corrected and breed-specific echocardiographic reference values calculated in the present study could be used to discriminate between normal and abnormal values in a given animal. [less ▲]

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See detailL'image de marque des villes wallonnes
Scatton, Loïc; Schmitz, Serge ULiege

in Belgeo (2017), 2016(1),

City branding practices have become widespread but few studies measure their effects on medium-sized cities. Through an analysis of the practices of city branding and internal and external images of the ... [more ▼]

City branding practices have become widespread but few studies measure their effects on medium-sized cities. Through an analysis of the practices of city branding and internal and external images of the cities of Liege and Charleroi, this article points out the relative strengths and weaknesses of the images of each of the Walloon cities, among their businessmen, vis-a vis those of the other Walloon city. The images of these two cities are composites and branding policies are still in their infancy. These policies have followed a top-down approach which may explain the limited use of the two brands even if they use ideas shared by local entrepreneurs. However the research underlines the absence of opinions on certain characteristics of the cities or a negative view which often requires works in the field but also better communication. [less ▲]

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See detailPrevalence of Frailty in Nursing Home Residents According to Various Diagnostic Tools
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; GILLAIN, Sophie ULiege et al

in Journal of Frailty & Aging (2017), 6(3), 122-8

Background: Although the theoretical foundations of frailty are well established in the literature, it remains an evolving concept lacking any unique definition or diagnostic criteria for use in clinical ... [more ▼]

Background: Although the theoretical foundations of frailty are well established in the literature, it remains an evolving concept lacking any unique definition or diagnostic criteria for use in clinical practice and epidemiological research. No consensus exists about the accurate prevalence rates of frailty. The various operational definitions of frailty can at least partly explain such discrepancies. Objective: To compare the prevalence of frailty, measured with different diagnostic tools, among elderly nursing home residents. Design: This is an analysis of baseline data collected among the SENIOR (Sample of Nursing home Elderly Individuals: an Observational Research) cohort. Setting: Nursing homes. Population: A total of 662 volunteer subjects from 28 nursing homes were included in this analysis. Among them, the mean age was 83.2 ± 8.99 years and 484 (72.5%) of them were women. Measurement: The percentages of frail and non-frail subjects were calculated according to 10 different definitions. Results: Prevalence of frailty varies from 1.70% (Frailty Index) to 76.3% (Groningen Frailty Indicator) depending on the tool used. Conclusions: The prevalence of frailty is highly dependent on the diagnostic tool used. It would be necessary to reach a consensus on which diagnostic tools to use if one wishes to have comparable data obtained in epidemiological studies. [less ▲]

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See detailRetos actuales en la caracterización de los flujos agua-aire en grandes obras hidráulicas
Valero Huerta, Daniel ULiege

in REVISTA HIDROLATINOAMERICANA (2017), 1

Present literature on air-water flows is briefly reviewed, including articles of the main five international Journals published along the last four years. Main advances in the most fruitful topics related ... [more ▼]

Present literature on air-water flows is briefly reviewed, including articles of the main five international Journals published along the last four years. Main advances in the most fruitful topics related to air entrainment are discussed. Main areas of interest are: stepped spillways, bubbles in pipe flows, numerical modelling and instrumentation. [less ▲]

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See detailWaveguide solar concentrator design with spectrally separated light
Michel, Céline ULiege; Blain, Pascal ULiege; Clermont, Lionel ULiege et al

in Solar Energy (2017), 157

In this article, we propose a new solar concentrator based on spectral splitting of sunlight. Spectral splitting has the objective to collect different spectra onto spectrally adapted solar cells for a ... [more ▼]

In this article, we propose a new solar concentrator based on spectral splitting of sunlight. Spectral splitting has the objective to collect different spectra onto spectrally adapted solar cells for a more efficient use of the Sun’s spectrum. Its combination with solar concentration makes an alternative to classical technologies. The proposed concentrator is composed of a diffractive/refractive optical element that spectrally splits and focuses the light onto a waveguide. The light is then conducted by total internal reflection towards the two specific solar cells. The optical concept and optimization of each element is presented in this paper. An adaptation for dye sensitized solar cells is performed. A geometrical factor around 5× is reached. Finally, theoretical optical efficiency, the manufacturing process and experimental testing with a collimated Sun simulator are presented. [less ▲]

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See detailObservations of asymmetric turbulent stirring in inner and marginal seas using satellite imagery
Karimova, Svetlana ULiege

in International Journal of Remote Sensing (2017), 38(6), 1642-1664

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale ... [more ▼]

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale cyclonic and anticyclonic eddies in a number of inner and marginal marine basins, namely in the Baltic, Black, North, and Western Mediterranean Seas. As research material, over 9700 eddy manifestations in the thermal infrared, visible-range, and radar satellite imagery were used. The analysis performed showed that in all the seas the typical and average values of the diameter of anticyclonic eddies were greater than those of cyclonic eddies. The main factor that defines the ratio between anticyclonic and cyclonic eddies in the basins under consideration was discovered to be the intensity of their surface currents. Thus, in the presence of a strong jet flow at the scales of about 2–4 baroclinic Rossby radii the cyclonic eddy dominance typical for smaller eddies was replaced by the anticyclonic one. If strong jet streams were missing, as that typical of the Baltic Sea, cyclonic eddies were prevailing over the entire spectrum of eddy diameters. [less ▲]

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See detailNew Minerals, Nomenclature and Classification (CNMNC), Newsletter 36. New minerals and nomenclature modifications approved in 2016 and 2017
Halenius, U; Hatert, Frédéric ULiege; Pasero, M et al

in European Journal of Mineralogy (2017), 29

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See detailOffensive de la Russie contre l'autorité de la jurisprudence européenne relative au droit de vote des détenus: la Cour constitutionnelle russe et le contrôle du caractère "exécutoire" d'un arrêt de la Cour européenne des droits de l'homme
Rosoux, Géraldine ULiege

in Revue Trimestrielle des Droits de l'Homme (2017)

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère ... [more ▼]

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère exécutoire d'un arrêt de la Cour européenne des droits de l'homme. Cette compétence a été exercée en ce qui concerne l'arrêt Anchugov et Gladkov c. Russie, relatif au droit de vote des détenus. [less ▲]

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See detailThe Sense of Taste in Eighteenth-Century France. Flavours of Silence and Words of Perception
Von Hoffmann, Viktoria ULiege

in De achttiende eeuw : Documentatieblad van de Werkgroep Achttiende Eeuw (2017), 48(1-2), 13-27

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See detailInvestigation of the added mass method for seismic design of lock gates
Buldgen, Loïc ULiege; Le Sourne, Hervé; Caprace, Jean-David ULiege et al

in Engineering Structures (2017)

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See detailEffects of parasite and historic driven selection on the diversity and structure of a MHC-II gene in a small mammal species (Peromyscus leucopus) undergoing range expansion
andré, adrien; millien, Virginie; Galan, Maxime et al

in Evolutionary Ecology (2017), DOI 10.1007/s10682-017-9898-z

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See detailFacies discrimination with electrical resistivity tomography using a probabilistic methodology: Effect of sensitivity and regularization
Hermans, Thomas ULiege; Irving, James

in Near Surface Geophysics (2017), 15

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution ... [more ▼]

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution of facies. However, inverted ERT images tend to be grossly smoothed versions of reality because of the regularization of the inverse problem. In this study, we use a probabilistic methodology based upon co-located measurements to assess the utility of ERT to identify hydrofacies in alluvial aquifers. With this methodology, ERT images are interpreted in terms of the probability of belonging to pre-defined hydrofacies. We first analyze through a synthetic study the ability of ERT to discriminate between different facies. As ERT data suffer from a loss of sensitivity with depth, we find that low sensitivity regions are more affected by misclassification. To counteract this effect, we adapt the probabilistic framework to include the spatially varying data sensitivity. We then apply our learning to a field case. For the latter, we consider two different regularization procedures. In contrast to the data sensitivity which affects the facies probability to a limited amount, the regularization can affect the probability maps more considerably because it has a strong influence on the spatial distribution of inverted resistivity. We find that a regularization strategy based on the most realistic prior information tends to offer the most reliable discrimination of facies. Our results confirm the ability of ERT surveys, when properly designed, to detect facies variations in alluvial aquifers. The method can be easily extended to other contexts. [less ▲]

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See detailImplementation of probabilistic algorithms by multi-chromophoric molecular networks with application to multiple travelling pathways
Fresch, B.; Remacle, Françoise ULiege; Levine, R. D.

in Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry (2017), 18

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See detailSingle- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.
Baron, Frédéric ULiege; Ruggeri, Annalisa; Beohou, Eric et al

in Journal of Hematology & Oncology (2017), 10(1), 128

BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of ... [more ▼]

BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of two CB units from different partially HLA-matched donors (double CBT) is frequently performed in patients who lack a sufficiently rich single CB unit. METHODS: We compared CBT outcomes in patients given single or double CBT following reduced-intensity conditioning (RIC) in a retrospective multicenter registry-based study. Inclusion criteria included adult (>/=18 years) patients, acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL), complete remission (CR) at the time of transplantation, first single (with a cryopreserved TNC >/= 2.5 x 107/kg) or double CBT between 2004 and 2014, and RIC conditioning. RESULTS: Data from 534 patients with AML (n = 408) or ALL (n = 126) receiving a first single (n = 172) or double (n = 362) CBT were included in the analyses. In univariate analysis, in comparison to patients transplanted with a single CB, double CB recipients had a similar incidence of neutrophil engraftment but a suggestion for a higher incidence of grade II-IV acute GVHD (36 versus 28%, P = 0.08). In multivariate analyses, in comparison to single CBT recipients, double CBT patients had a comparable incidence of relapse (HR = 0.9, P = 0.5) and of nonrelapse mortality (HR = 0.8, P = 0.3), as well as comparable overall (HR = 0.8, P = 0.17), leukemia-free (HR = 0.8, P = 0.2) and GVHD-free, relapse-free (HR = 1.0, P = 0.3) survival. CONCLUSIONS: These data failed to demonstrate better transplantation outcomes in adult patients receiving double CBT in comparison to those receiving single CBT with adequate TNC after RIC. [less ▲]

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See detailÉtude sur les caractéristiques psychologiques des hommes auteurs de violences conjugales : quel type de fragilité psychique le passage à l’acte violent dissimule-t-il ?
Di Piazza, Laetitia ULiege; Blavier, Adelaïde ULiege; Kowal, Cécile et al

in Annales Médico-Psychologiques (2017)

Introduction Historically, intimate partner violence has been ignored and minimized, despite its seriousness and widespread prevalence in our culture. In the past three decades, many studies have ... [more ▼]

Introduction Historically, intimate partner violence has been ignored and minimized, despite its seriousness and widespread prevalence in our culture. In the past three decades, many studies have addressed the question of the impact of intimate partner violence on physical or mental health for victims (spouses, ex-partners and children). But, what about authors? Currently, due to the multifactorial character of the phenomenon of domestic violence, it is still difficult to estimate the impact of the existing therapeutic programs which offer a support for the authors of this violence. The current study sought to examine the association between trait impulsivity, alexithymia and depression and the perpetration of physical and psychological intimate partner violence. We focused on particular psychological characteristics that would seem to have much potential as an aid to understand this phenomenon and its prevention and/or treatment. Patients and methods Fifty-three male offenders were surveyed using self-report questionnaires to assess emotional distress (BDI), impulsive behavior (BIS-11) and alexithymia (TAS-20), the inability to experience and express subjective emotions, prior to therapeutic program participation. Results Findings indicated that both alexithymia and depression were significantly associated with violence perpetration. Analyses showed that male intimate partner violence offender reported more depressive feelings and more difficulties to express his emotions than did general population. Furthermore, there are positive and significant correlations between alexithymia, impulsivity and depression. Therefore, if male offenders have difficulties to describe and identify their emotions, they will tend to have more depressive symptoms and also more impulsive behavior. However, we do not observe a difference between men who consult voluntarily therapeutic programs and those who have been forced by legal measure of constraint. Conclusions The present findings continue to suggest a strong link between alexithymia and domestic violence as showed by others studies. Additional researches are clearly needed and may lead not only to a better understanding of aggression but also to the development of better therapeutic interventions. [less ▲]

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See detailEquine Atypical Myopathy in the UK: Epidemiological characteristics of cases reported from 2011 to 2015 and factors associated with survival
Gonzalez-Medina, S.; Ireland, J. L.; Piercy, R. J. et al

in Equine Veterinary Journal (2017)

BACKGROUND: Equine atypical myopathy (AM) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from Acer pseudoplatanus tree. Despite the wide distribution of ... [more ▼]

BACKGROUND: Equine atypical myopathy (AM) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from Acer pseudoplatanus tree. Despite the wide distribution of this tree species in the UK, the number of cases reported annually varies, and there has been an apparent increase in prevalence in recent years. Although AM was first recognised in the UK, epidemiological studies have never been conducted focused solely on this country. OBJECTIVES: To describe the spatiotemporal distribution, presentation, treatment and outcome of AM cases reported in the UK. STUDY DESIGN: Retrospective case series. METHODS: British AM cases reported to the atypical myopathy alert website, between 2011 and 2015 were included (n = 224). Data were obtained via standardised epidemiological questionnaires from owners and veterinarians. Factors associated with survival were assessed using logistic regression. RESULTS: Most cases reported were from England (87.9%). Survival was 38.6% (n = 73/189). Clinical factors associated with reduced odds of survival included, hypothermia (odds ratio (OR) 0.18; CI 0.06-0.57; p = 0.01), bladder distension (OR 0.11; CI 0.02-0.59; p = 0.01), tachycardia (OR 0.97; CI 0.94-0.99; p = 0.04) and serum creatine kinase activity >100,000 IU/L (OR 0.17; CI 0.04-0.68; p = 0.01) in the univariable analysis as well as recumbency. The latter was the only sign retained in multivariable analysis (OR = 0.19; CI 0.06-0.62; p = 0.006). Administration of vitamins during the disease was associated with survival (OR 3.75; CI 1.21-11.57; p = 0.02). MAIN LIMITATIONS: Reporting cases to the atypical myopathy alert group is voluntary; therefore, under-reporting will result in underestimation of AM cases; furthermore, direct owner-reporting could have introduced misdiagnosis bias. CONCLUSION: Some areas of the UK reported AM cases more commonly. Clinical signs such as recumbency, rectal temperature, distended bladder and serum CK activity might be useful prognostic indicators though should be considered in the context of the clinical picture. Treatment with vitamins increases survival. This article is protected by copyright. All rights reserved. [less ▲]

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See detailThe Roles of Spinochromes in Four Shallow Water Tropical Sea Urchins and Their Potential as Bioactive Pharmacological Agents.
Brasseur, Lola; Hennebert, Elise; Fievez, Laurence ULiege et al

in Marine Drugs (2017), 15(6),

Spinochromes are principally known to be involved in sea urchin pigmentation as well as for their potentially interesting pharmacological properties. To assess their biological role in sea urchin ... [more ▼]

Spinochromes are principally known to be involved in sea urchin pigmentation as well as for their potentially interesting pharmacological properties. To assess their biological role in sea urchin physiology, experiments are undertaken on crude extracts from four species and on four isolated spinochromes in order to test their antibacterial, antioxidant, inflammatory and cytotoxic activities. First, the antibacterial assays show that the use of crude extracts as representatives of antibacterial effects of spinochromes are inaccurate. The assays on purified spinochromes showed a decrease in the growth of four strains with an intensity depending on the spinochromes/bacteria system, revealing the participation of spinochromes in the defense system against microorganisms. Secondly, in the 2,2-diphenyl-1-picrylhydrazyl antioxidant assays, spinochromes show an enhanced activity compared to the positive control. This latter observation suggests their involvement in ultraviolet radiation protection. Third, spinochromes present a pro-inflammatory effect on lipopolysaccharide-stimulated macrophages, highlighting their possible implication in the sea urchin immune system. Finally, cytotoxicity assays based on Trypan blue exclusion, performed in view of their possible future applications as drugs, show a weak cytotoxicity of these compounds against human cells. In conclusion, all results confirm the implication of spinochromes in sea urchin defense mechanisms against their external environment and reveal their potential for pharmacological and agronomical industries. [less ▲]

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See detailFire resistance of DELTABEAM® composite beams: a numerical investigation
Maraveas, Chrysanthos ULiege

in Journal of Structural Fire Engineering (2017)

Purpose – The DELTA® beam composite floor system is a recently developed shallow floor type that has seen many applications in contemporary construction. It involves partially encasing DELTA® steel beams ... [more ▼]

Purpose – The DELTA® beam composite floor system is a recently developed shallow floor type that has seen many applications in contemporary construction. It involves partially encasing DELTA® steel beams in concrete, with the lower flange remaining exposed. Besides the satisfactory behavior of the system at ambient conditions, understanding its response under elevated temperatures is critical in evaluating its overall performance. Despite certification from the manufacturing company that the system has adequate fire resistance, its behavior under fire conditions has neither been investigated to depth nor reported in detail. The purpose of this paper is the detailed numerical investigation of their behavior in fire. For this reason, the finite element method was implemented in this paper to simulate the response of such beams subjected to fire. Material properties were modeled according to the Eurocodes. The coupled thermal-structural parametric analyses involved four different variations of the “shortest” and “deepest” cross-section (eight case studies in total) specified by the manufacturing company. Other simulations of these cross-sections, in which either the thermal expansion or the structural load were not taken into account, were carried out for comparison purposes. Design/methodology/approach – The methodology for simulating such systems, which has been successfully implemented and validated against fire test results elsewhere (Maraveas et al., 2012) was also followed here. To investigate the statement made by Maraveas et al. (2014) and the equations proposed by Zaharia and Franssen (2012) that the insulation is not so effective for “short” cross-sections, two beams, one with a D20-200 (Deltabeam Technical Manual, 2013) cross-section (shallowest section) and one with a D50-600 (Deltabeam Technical Manual, 2013) cross-section (deepest section), were simulated in this paper for comparison purposes. Additionally, reasonable assumptions were made for the cross-sectional dimensions not specified by the manufacturer (Deltabeam Technical Manual, 2013) and parametric analyses were carried out to investigate their effect on the structural response of the system. Findings – Composite DELTA® beams can achieve fire resistances ranging from 120 to 180 min, depending on the depth and geometry of their cross-section, with deeper sections displaying a better fire response. The intense thermal bowing that occurs when these beams are heated from below has a more pronounced effect, in terms of thermally induced deflections for deeper sections. The satisfactory fire resistance of these beams is achieved due to the action of the concrete encased web and the reinforcement which compensate for the loss of the exposed lower flange. Increasing the thickness of the web in deeper sections improves their fire rating up to 180 min. The thickness of the lower flange affects the fire rating of the beams only in a minor way. Practical/implications – The paper describes a numerical methodology to estimate the fire resistance of complex flooring systems. [less ▲]

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See detailDrawbacks and benefits of hygienic behavior in honey bees (Apis mellifera L.): a review
Leclercq, Gil; Pannebakker, Bart; Gengler, Nicolas ULiege et al

in Journal of Apicultural Research (2017), 56(4), 366-375

The hygienic behavior of honey bee workers contributes to the social immunity of colonies. The ability of workers to detect and remove unhealthy or dead brood prevents the transmission of brood diseases ... [more ▼]

The hygienic behavior of honey bee workers contributes to the social immunity of colonies. The ability of workers to detect and remove unhealthy or dead brood prevents the transmission of brood diseases inside the colony. Over the last five decades, this trait has been extensively studied and improved in several research and breeding programs. Given the strong interest for hygienic behavior, we here review the costs and benefits associated with this trait, extending preceding reviews on this subject from the late 1990s. Since the 1990s, there have been no major new insights on the efficiency of this behavior against American foulbrood and chalkbrood. However, the number of publications on hygienic behavior against the mite Varroa destructor has considerably increased, fueling the debate regarding the efficiency of hygienic behavior against this parasite. Breeding programs have shown that selection for a specific trait might also impact other traits. Thus, we also review the cost of trade-offs between hygienic behavior and other economically important traits for bee breeders. Overall, the benefits of hygienic behavior seem to largely outweigh its costs for both colonies and bee breeders. [less ▲]

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See detailAu coeur de la protection "multi-niveaux" et du dialogue juridictionnel : la "dématérialisation" des droits fondamentaux comme clé de lecture du raisonnement actuel dans le domaine des droits fondamentaux
Rosoux, Géraldine ULiege

in Fundamentos (2017), 9

L'article examine les différents raisonnements suivis par la Cour européenne des droits de l'homme, la Cour de justice de l'Union européenne et le juge constitutionnel belge, pour faire face à la ... [more ▼]

L'article examine les différents raisonnements suivis par la Cour européenne des droits de l'homme, la Cour de justice de l'Union européenne et le juge constitutionnel belge, pour faire face à la protection "multi-niveaux" des droits fondamentaux. [less ▲]

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See detailPatterns of metal distribution in hypersaline microbialites during early diagenesis: Implications for the fossil record
Sforna, Marie-Catherine ULiege; Daye, Mirna; Philippot, Pascal et al

in Geobiology (2017), 15(2), 259-279

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See detailAlpha-lipoic acid impairs body weight gain of young broiler chicks via modulating peripheral AMPK.
Wang, Yufeng; Everaert, Nadia ULiege; Song, Zhigang et al

in Comparative Biochemistry and Physiology Part A : Molecular & Integrative Physiology (2017), 211

In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was ... [more ▼]

In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was aimed to explore the potential role of hepatic AMPK in the energy homeostasis of broiler chickens. Diets with 0, 0.05% or 0.1% alpha-lipoic acid (alpha-LA), a known AMPK inhibitor were provided to broiler chicks for 7days. As a result, alpha-LA supplementation decreased the relative growth rate of broiler chicks. Hepatic AMPKalpha2 mRNA levels were significantly upregulated by dietary alpha-LA, in concert with the increased phosphorylated AMPKalpha protein levels. In addition, hepatic FAS mRNA levels together with the malonyl-CoA to total CoA ester ratio were reduced by alpha-LA supplementation. Moreover, the hepatic phosphorylated glycogen synthase levels were increased resulting in a markedly decreased hepatic glycogen content. In conclusion, dietary alpha-LA supplementation decreased the in vivo hepatic glycogenesis and lipogenesis via stimulating hepatic AMPKalpha mRNA levels and the phosphorylated gene product. The stimulatory effect of alpha-LA on hepatic AMPK mRNA and pAMPKalpha protein levels together with our previous observations regarding its inhibitory effect on hypothalamic AMPK may have altered the energy balance and hence impaired body weight gain of broiler chicks. [less ▲]

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See detailChronic illness needing palliative care in Kinshasa hospitals, democratic republic of Congo
Lofandjola Masumbuku, Jacques ULiege

in Tropical Medicine and Health (2017), 45

Chronic illnesses are a major public health problem in low-income countries. In the Democratic Republic of the Congo (DRC), few data are available, especially in palliative care. In this context, the ... [more ▼]

Chronic illnesses are a major public health problem in low-income countries. In the Democratic Republic of the Congo (DRC), few data are available, especially in palliative care. In this context, the present study aimed at describing the patterns of diseases in Kinshasa hospitals as well as risk factors associated with patients’ evolving status and length of hospital stay. [less ▲]

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See detailDiet effects on bumblebee health
Roger, N.; Michez, D.; Wattiez, R. et al

in Journal of Insect Physiology (2017), 96

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as ... [more ▼]

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as the ability of an organism to mount an immune response, either in cellular, humoral or behavioural forms. In insects, immune capacity can be affected by a variety of factors including pesticides, genetic diversity or diet. Here we focus on an important species of domesticated pollinator, Bombus terrestris, and the potential impact of a poor pollen diet (low nutritional content and toxic) on its health. We investigate three responses at both colony and individual levels: behavioural, humoral and cellular. Our results show that poor pollen diets decrease larval and pupal masses and increase larval ejection as well as adult constitutive immunity (i.e., prophenoloxidase assays). The susceptibility of bumblebees to disease and infection might therefore be greater after a nutritive stress. These findings raise the importance of available plant hosts, especially floral plant species providing pollen with suitable nutritive quality (i.e., nutrient pollen content) for bumblebees. © 2016 Elsevier Ltd [less ▲]

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See detailDo sex reversal procedures differentially affect agonistic behaviours and sex steroid levels depending on the sexual genotype in Nile tilapia?
Gennotte, Vincent ULiege; Akonkwa, Balagizi; Mélard, Charles ULiege et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (2017), 327(4), 153-162

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY ... [more ▼]

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY males, XY and YY females, and XX males expressed higher level of aggressiveness that could be related to higher levels of 17β-oestradiol and 11-ketotestosterone respectively. Our results suggest that the presence of a Y chromosome increases aggressiveness in females. However, since the same relationship between aggressiveness and the Y chromosome is not observed in males, we can hypothesize that the differences in aggressiveness are not directly dependent on the genotype but on the sex reversal procedures applied on young fry during their sexual differentiation to produce these breeders. These hormonal treatments could have permanently modified the development of the brain and consequently influenced the behaviour of adults independently of their genotype. In both hypotheses (genotype or sex reversal influence), the causes of behavioural modifications have to be searched in an early modification of the brain sexual differentiation. [less ▲]

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See detailLes « cavaliers budgétaires » sont-ils éphémères ? Une controverse qui perdure (note sous C.C., arrêt n° 58/2016 du 28 avril 2016)
Miny, Xavier ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (3), 110-117

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions ... [more ▼]

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions de budget et de cavalier budgétaire, ainsi que sur la durée de vie de ce genre controversé de dispositions et sur la compétence d’avis du Conseil d’État en la matière. Confrontée pour la première fois à certaines problématiques qu’engendrent les cavaliers budgétaires, la Cour constitutionnelle s’est néanmoins refusée à trancher l’ensemble des débats. [less ▲]

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See detailGenomics of a revived breed: Case study of the Belgian campine cattle.
Francois, Liesbeth; Wijnrocx, Katrien; Colinet, Frédéric ULiege et al

in PLoS ONE (2017), 12(4), 0175916

Through centuries of both natural and artificial selection, a variety of local cattle populations arose with highly specific phenotypes. However, the intensification and expansion of scale in animal ... [more ▼]

Through centuries of both natural and artificial selection, a variety of local cattle populations arose with highly specific phenotypes. However, the intensification and expansion of scale in animal production systems led to the predominance of a few highly productive cattle breeds. The loss of local populations is often considered irreversible and with them specific qualities and rare variants could be lost as well. Over these last years, the interest in these local breeds has increased again leading to increasing efforts to conserve these breeds or even revive lost populations, e.g. through the use of crosses with similar breeds. However, the remaining populations are expected to contain crossbred individuals resulting from introgressions. They are likely to carry exogenous genes that affect the breed's authenticity on a genomic level. Using the revived Campine breed as a case study, 289 individuals registered as purebreds were genotyped on the Illumina BovineSNP50. In addition, genomic information on the Illumina BovineHD and Illumina BovineSNP50 of ten breeds was available to assess the current population structure, genetic diversity, and introgression with phenotypically similar and/or historically related breeds. Introgression with Holstein and beef cattle genotypes was limited to only a few farms. While the current population shows a substantial amount of within-breed variation, the majority of genotypes can be separated from other breeds in the study, supporting the re-establishment of the Campine breed. The majority of the population is genetically close to the Deep Red (NL), Improved Red (NL) and Eastern Belgium Red and White (BE) cattle, breeds known for their historical ties to the Campine breed. This would support an open herdbook policy, thereby increasing the population size and consequently providing a more secure future for the breed. [less ▲]

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See detailHyperinsulinemia and elevated systolic blood pressure independently predict white matter hyperintensities with associated cognitive decrement in the middle-aged offspring of dementia patients.
Hawkins, Keith A.; Emadi, Nazli; Pearlson, Godfrey D. et al

in Metabolic Brain Disease (2017)

Cerebrovascular disease is an independent risk factor for dementia that may also be synergistic with Alzheimer's disease. In recent years attention has switched from cerebral infarcts to microvascular ... [more ▼]

Cerebrovascular disease is an independent risk factor for dementia that may also be synergistic with Alzheimer's disease. In recent years attention has switched from cerebral infarcts to microvascular disease as the primary cause of cerebrovascular cognitive decline, with damage to the white matter the primary mechanism. Uncertainties remain regarding the risks posed by different types vascular threat, the extent to which cerebrovascular damage occurs in middle age, and whether relatively "normal" amounts of white matter damage are accompanied by meaningful degrees of cognitive decline. We explored these issues via laboratory, cardiovascular, cognitive, and magnetic resonance imaging (MRI) data in 67 middle-aged cognitively normal offspring of dementia patients. The sample was enriched for vascular risk. Plasma insulin, 24-h systolic blood pressure, body mass index, age, and % small dense LDL cholesterol were the strongest correlates of MRI white matter hyperintensity (WMH) volume. With shared variance controlled for, 24 h systolic BP, plasma insulin, and age remained as significant predictors of WMH volume. An interaction variable (24 h BP * insulin) did not improve the prediction of WMH. WMH volume correlated negatively with cognition. No evidence for an ApoE epsilon4 effect emerged for either WMH or cognition. Hypertension and hyperinsulinemia appear to pose independent, consequential threats to the cerebral small vessel vasculature in middle age, reflected in the presence of areas of WMH on MRI scans. Our data show that even modest WMH volumes in middle age are associated with cognitive decrement, underscoring the importance of aggressive treatment and lifestyle modifications to address vascular risk throughout adulthood. [less ▲]

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See detailCerebral metabolism before and after external trigeminal nerve stimulation in episodic migraine
MAGIS, Delphine ULiege; D'Ostilio, Kevin ULiege; Thibaut, Aurore ULiege et al

in Cephalalgia : An International Journal of Headache (2017)

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See detailCorn stover as feedstock for the production of ethanol: chemical composition of different anatomical fractions and varieties
Berchem, Thomas ULiege; Roiseux, Olivier; Vanderghem, Caroline et al

in Biofuels, Bioproducts and Biorefining (2017)

The available grain corn stover produced in Belgium is estimated at 290 000 dry tons, a suffi cient amount to supply a biorefi nery. Differences regarding size, prematurity, and drying speed have been ... [more ▼]

The available grain corn stover produced in Belgium is estimated at 290 000 dry tons, a suffi cient amount to supply a biorefi nery. Differences regarding size, prematurity, and drying speed have been observed among the cultivated grain corn varieties in Wallonia (Belgium). This study aims to evaluate the variation in composition of different anatomical fractions (stalks, leaves, cobs, and husks) of three Walloon varieties of grain corn stover (SyMultitop, Padrino, and Alduna) with significant production volumes. In addition, the Padrino variety was assessed for variation in chemical composition at three harvesting times. Walloon grain corn stover contains large amounts of polysaccharides (33.4% to 41.3% of glucans and 13.9% to 28.2% of xylans) and lignin (10.4% to 15.3%). Some différences were noted between varieties and anatomical fractions. Depending on how the feedstock is harvested, it is possible to produce between 79 and 81 M liters of ethanol per year without adversely affecting soil sustainability. [less ▲]

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See detailSacred Alliance or Pact with the Devil? How and Why Social Enterprises Collaborate with Mainstream Businesses in the Fair Trade Sector
Huybrechts, Benjamin ULiege; Nicholls, Alex; Edinger, Katharina

in Entrepreneurship and Regional Development (2017), 29(7-8), 586-608

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises ... [more ▼]

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises interact with mainstream businesses and to what extent their collaboration patterns reflect a vision of how their social mission should be implemented and institutionalized. The empirical analysis is derived from a qualitative study of ‘fair trade’ – a hybrid model created by social enterprises and using market mechanisms to support small-scale producers in developing countries and to advocate for changes in international trading practices. The findings highlight three strategies used by fair trade social enterprises to manage their interactions with mainstream businesses: sector solidarity, selective engagement, and active appropriation. This paper suggests that each strategy is motivated by a different vision of how best to articulate the social mission of fair trade via specific types of collaborations. It also notes how each vision has a distinct pattern of institutionalization at the field level. This paper adds to the emergent literatures on social enterprise and social entrepreneurship, fair trade, cross-sector collaboration and hybrid organizing. [less ▲]

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See detailBeyond stuttering: Speech disfluencies in normally fluent French-speaking children at age 4
Leclercq, Anne-Lise ULiege; Suaire, Pauline; Moyse, Astrid

in Clinical Linguistics & Phonetics (2017)

The aim of this study was to establish normative data on the speech disfluencies of normally fluent French-speaking children at age 4, an age at which stuttering has begun in 95% of children who stutter ... [more ▼]

The aim of this study was to establish normative data on the speech disfluencies of normally fluent French-speaking children at age 4, an age at which stuttering has begun in 95% of children who stutter (Yairi & Ambrose, 2013). Fifty monolingual French-speaking children who do not stutter participated in the study. Analyses of a conversational speech sample comprising 250–550 words revealed an average of 10% total disfluencies, 2% stuttering-like disfluencies and around 8% non-stuttered disfluencies. Possible explanations for these high speech disfluency frequencies are discussed, including explanations linked to French in particular. The results shed light on the importance of normative data specific to each language. [less ▲]

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See detailTemporal dynamics of soil microbial communities below the seedbed under two contrasting tillage regimes
Degrune, Florine; Theodorakopoulos, Nicolas; Colinet, Gilles ULiege et al

in Frontiers in Microbiology (2017)

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See detailResponse of Jupiter's auroras to conditions in the interplanetary medium as measured by the Hubble Space Telescope and Juno
Nichols, J. D.; Badman, S. V.; Bagenal, F. et al

in Geophysical Research Letters (2017)

We present the first comparison of Jupiter's auroral morphology with an extended, continuous and complete set of near-Jupiter interplanetary data, revealing the response of Jupiter's auroras to the ... [more ▼]

We present the first comparison of Jupiter's auroral morphology with an extended, continuous and complete set of near-Jupiter interplanetary data, revealing the response of Jupiter's auroras to the interplanetary conditions. We show that for ∼1-3 days following compression region onset the planet's main emission brightened. A duskside poleward region also brightened during compressions, as well as during shallow rarefaction conditions at the start of the program. The power emitted from the noon active region did not exhibit dependence on any interplanetary parameter, though the morphology typically differed between rarefactions and compressions. The auroras equatorward of the main emission brightened over ∼10 days following an interval of increased volcanic activity on Io. These results show that the dependence of Jupiter's magnetosphere and auroras on the interplanetary conditions are more diverse than previously thought. [less ▲]

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See detailAssessment of extreme value overestimations with equivalent static wind loads
Blaise, Nicolas ULiege; Andrianne, Thomas ULiege; Denoël, Vincent ULiege

in Journal of Wind Engineering & Industrial Aerodynamics (2017)

The wind-resistant design using equivalent static wind loads is convenient for structural engineers. This paper studies the reliability of such an approach in the case of non-Gaussianities in both ... [more ▼]

The wind-resistant design using equivalent static wind loads is convenient for structural engineers. This paper studies the reliability of such an approach in the case of non-Gaussianities in both aerodynamic pressures and responses. These non-Gaussianities are responsible for overestimations of envelope values and may result in uneconomical designs, if not appropriately understood, assessed and addressed. In this study, it is shown that the equivalent static wind loads defined with the Conditional Expected Load method, which extends the physical meaning of the Load-Response Correlation approach in a non-Gaussian framework, improves the issue of overestimations of envelope values. Several envelopes of structural responses are considered: the mean of extremes and the 86% quantiles of extremes, together with two reference periods (10 min and 1 h). Extensive wind tunnel measurements have been collected, which correspond to 371 h full scale. This study is undertaken for quasi-static analysis of structures and is illustrated with a low-rise building. [less ▲]

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See detailIconic virtues of diagrams. Peirce on ampliative reasoning
Leclercq, Bruno ULiege

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

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See detailAb initio study of hydrogenic effective mass impurities in Si nanowires
Peelaers, Hartwin; Durgun, Engin; Partoens, Bart et al

in Journal of Physics : Condensed Matter (2017), 29

The effect of B and P dopants on the band structure of Si nanowires is studied using electronic structure calculations based on density functional theory. At low concentrations a dispersionless band is ... [more ▼]

The effect of B and P dopants on the band structure of Si nanowires is studied using electronic structure calculations based on density functional theory. At low concentrations a dispersionless band is formed, clearly distinguishable from the valence and conduction bands. Although this band is evidently induced by the dopant impurity, it turns out to have purely Si character. These results can be rigorously analyzed in the framework of effective mass theory. In the process we resolve some common misconceptions about the physics of hydrogenic shallow impurities, which can be more clearly elucidated in the case of nanowires than would be possible for bulk Si. We also show the importance of correctly describing the effect of dielectric confinement, which is not included in traditional electronic structure calculations, by comparing the obtained results with those of G0W0 calculations. [less ▲]

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See detailThoracic endovascular aortic repair (TEVAR) in proximal (type A) aortic dissection: Ready for a broader application?
Nienaber, Christoph A.; Sakalihasan, Natzi ULiege; Clough, Rachel E. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2017)

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role ... [more ▼]

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role in managing proximal aortic pathologies is unknown-this is important because in proximal (Stanford type A) aortic dissections, 10% to 30% are not accepted for surgery and 30% to 50% are technically amenable for TEVAR. We describe our case series of type A aortic dissections treated by using TEVAR. METHODS: Between year 2009 and 2016, 12 patients with acute, subacute, or chronic type A aortic dissection with the proximal entry tear located between the coronaries and brachiocephalic artery were treated with TEVAR at 3 centers. Various stent-graft configurations were used to seal the proximal entry tear in the ascending aorta under rapid pacing. RESULTS: A total of 12 patients (9 male, 3 female), mean age 81 +/- 7 years, EuroSCORE II 9.1 +/- 4.5, underwent TEVAR for the treatment of type A aortic dissection. Procedural success was achieved in 11 of 12 patients (91.7%). There was 1 minor stroke and 1 intraprocedural death. No additional deaths were reported at 30 days. At 36 months, there were 4 further deaths (all from nonaortic causes). The mean survival of these 4 deceased was 23 months (range 15-36 months). Follow-up computed tomography demonstrated favorable aortic remodeling. CONCLUSIONS: TEVAR is feasible and reveals promising early results in selected patients with type A aortic dissection who are poor candidates for surgical repair. The current iteration of stent-graft technology, however, needs to be adapted to features specific to the ascending aorta. [less ▲]

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See detailGeneralisability of a Virtual Trials Method for Glycaemic Control in Intensive Care.
Dickson, Jennifer L.; Stewart, Kent W.; Pretty, Christopher G. et al

in IEEE transactions on bio-medical engineering (2017)

BACKGROUND: Elevated blood glucose (BG) concentrations (Hyperglycaemia) are a common complication in critically ill patients. Insulin therapy is commonly used to treat hyperglycaemia, but metabolic ... [more ▼]

BACKGROUND: Elevated blood glucose (BG) concentrations (Hyperglycaemia) are a common complication in critically ill patients. Insulin therapy is commonly used to treat hyperglycaemia, but metabolic variability often results in poor BG control and low BG (hypoglycaemia). OBJECTIVE: This paper presents a model-based virtual trial method for glycaemic control protocol design, and evaluates its generalisability across different populations. METHODS: Model-based insulin sensitivity (SI) was used to create virtual patients from clinical data from three different ICUs in New Zealand, Hungary, and Belgium. Glycaemic results from simulation of virtual patients under their original protocol (self-simulation) and protocols from other units (cross-simulation) were compared. RESULTS: Differences were found between the three cohorts in median SI and inter-patient variability in SI. However, hour-to-hour intra-patient variability in SI was found to be consistent between cohorts. Self and cross-simulation results were found to have overall similarity and consistency, though results may differ in the first 24-48 hours due to different cohort starting BG and underlying SI. CONCLUSIONS AND SIGNIFICANCE: Virtual patients and the virtual trial method were found to be generalisable across different ICUs. This virtual trial method is useful for in silico protocol design and testing, given an understanding of the underlying assumptions and limitations of this method. [less ▲]

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See detailCRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens
Collonnier, Cécile; Epert, Aline; Mara, Kostlend et al

in Plant Biotechnology Journal (2017), 15

The ability to address the CRISPR-Cas9 nuclease complex to any target DNA using customizable single-guide RNAs has now permitted genome engineering in many species. Here, we report its first successful ... [more ▼]

The ability to address the CRISPR-Cas9 nuclease complex to any target DNA using customizable single-guide RNAs has now permitted genome engineering in many species. Here, we report its first successful use in a nonvascular plant, the moss Physcomitrella patens. Single-guide RNAs (sgRNAs) were designed to target an endogenous reporter gene, PpAPT, whose inactivation confers resistance to 2-fluoroadenine. Transformation of moss protoplasts with these sgRNAs and the Cas9 coding sequence from Streptococcus pyogenes triggered mutagenesis at the PpAPT target in about 2% of the regenerated plants. Mainly, deletions were observed, most of them resulting from alternative end-joining (alt-EJ)-driven repair. We further demonstrate that, in the presence of a donor DNA sharing sequence homology with the PpAPT gene, most transgene integration events occur by homology-driven repair (HDR) at the target locus but also that Cas9- induced double-strand breaks are repaired with almost equal frequencies by mutagenic illegitimate recombination. Finally, we establish that a significant fraction of HDR-mediated gene targeting events (30%) is still possible in the absence of PpRAD51 protein, indicating that CRISPR-induced HDR is only partially mediated by the classical homologous recombination pathway. [less ▲]

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See detailA nonlinear state-space approach to hysteresis identification
Noël, Jean-Philippe ULiege; Esfahani, Alireza; Kerschen, Gaëtan ULiege et al

in Mechanical Systems & Signal Processing (2017), 84

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an ... [more ▼]

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an assumption may be a hard requirement to handle in real applications, since hysteresis is a highly individualistic nonlinear behaviour. The present paper adopts a black-box approach based on nonlinear state-space models to identify hysteresis dynamics. This approach is shown to provide a general framework to hysteresis identification, featuring flexibility and parsimony of representation. Nonlinear model terms are constructed as a multivariate polynomial in the state variables, and parameter estimation is performed by minimising weighted least-squares cost functions. Technical issues, including the selection of the model order and the polynomial degree, are discussed, and model validation is achieved in both broadband and sine conditions. The study is carried out numerically by exploiting synthetic data generated via the Bouc-Wen equations. [less ▲]

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See detailImpaired familiarity in individuals at risk for Alzheimer's disease: Commentary on Schoemaker et al. (2016)
Bastin, Christine ULiege; Besson, Gabriel ULiege

in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017), 6

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See detailCanagliflozin: A Review in Type 2 Diabetes.
Deeks, Emma D.; Scheen, André ULiege

in Drugs (2017)

Canagliflozin (Invokana(R)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D). Canagliflozin lowers ... [more ▼]

Canagliflozin (Invokana(R)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D). Canagliflozin lowers blood glucose levels independently of insulin, with the inhibition of SGLT2 reducing renal reabsorption of glucose and increasing excretion of glucose in the urine. In well-designed clinical trials, canagliflozin (as first-line monotherapy or add-on therapy to other antihyperglycaemic agents) improved glycaemic control in adults with T2D, including those of older age and/or at high cardiovascular (CV) risk, and also had beneficial effects on their bodyweight and blood pressure (BP). CV risk reduction, as well as possible renal benefits, were also seen with canagliflozin in T2D patients at high CV risk in the CANVAS Program, an integrated analysis of two large CV outcomes studies. Canagliflozin was generally well tolerated, had a low risk of hypoglycaemia and was most commonly associated with adverse events such as genital and urinary tract infections and increased urination, consistent with its mechanism of action. Although the amputation and fracture risk observed among recipients of the drug require further investigation, canagliflozin is an important option for T2D management in adults. [less ▲]

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See detailThe genus Psiadia: Review of traditional uses, phytochemistry and pharmacology.
Mahadeo, Keshika; Grondin, Isabelle; Kodja, Hippolyte et al

in Journal of Ethnopharmacology (2017), 210

ETHNOPHARMACOLOGICAL RELEVANCE: The genus Psiadia Jacq. ex. Willd. belongs to the Asteraceae family and includes more than 60 species. This genus grows in tropical and subtropical regions, being ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: The genus Psiadia Jacq. ex. Willd. belongs to the Asteraceae family and includes more than 60 species. This genus grows in tropical and subtropical regions, being especially well represented in Madagascar and the Mascarene Islands (La Reunion, Mauritius and Rodrigues). Several Psiadia species have been used traditionally for their medicinal properties in Africa and the Mascarene Islands. Based on traditional knowledge, various phytochemical and pharmacological studies have been conducted. However there are no recent papers that provide an overview of the medicinal potential of Psiadia species. Therefore, the aim of this review is to provide a comprehensive summary of the botany, phytochemistry and pharmacology of Psiadia and to highlight the gaps in our knowledge for future research opportunities. MATERIALS AND METHODS: The available information on traditional uses, phytochemistry and biological activities of the genus Psiadia was collected from scientific databases through a search using the keyword 'Psiadia' in 'Google Scholar', 'Pubmed', 'Sciencedirect', 'SpringerLink', 'Web of Science', 'Wiley' and 'Scifinder'. Additionally, published books and unpublished Ph.D. and MSc. dissertations were consulted for botanical information and chemical composition. RESULTS: Historically, species of the genus Psiadia have been used to treat a wide range of ailments including abdominal pains, colds, fevers, bronchitis, asthma, rheumatoid arthritis, skin infections and liver disorders among others. Phytochemical works led to the isolation of flavonoids, phenylpropanoids, coumarins and terpenoids. Furthermore, phytochemical compositions of the essential oils of some species have been evaluated. Crude extracts, essential oils and isolated molecules showed in vitro pharmacological activities, such as antimicrobial, anti-viral, anti-inflammatory, antiplasmodial and antileishmanial activities. Crude extracts of Psiadia dentata and Psiadia arguta have specifically been found to be potentially useful for inhibition of growth of Plasmodium falciparum. However, pharmacological data on this particular genus is quite limited. Further research is necessary to determine the active compounds and the underlying mechanisms. [less ▲]

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See detailOccurrence of graft-versus-host disease increases mortality after umbilical cord blood transplantation for acute myeloid leukaemia: a report from Eurocord and the ALWP of the EBMT.
Baron, Frédéric ULiege; Ruggeri, A.; Beohou, E. et al

in Journal of Internal Medicine (2017)

BACKGROUND: The efficacy of umbilical cord blood transplantation (UCBT) as treatment for acute myeloid leukaemia (AML) relies on immune-mediated graft-versus-leukaemia effects. Previous studies have ... [more ▼]

BACKGROUND: The efficacy of umbilical cord blood transplantation (UCBT) as treatment for acute myeloid leukaemia (AML) relies on immune-mediated graft-versus-leukaemia effects. Previous studies have suggested a strong association between graft-versus-host disease (GVHD) occurrence and graft-versus-leukaemia effects after allogeneic hematopoietic cell transplantation. METHODS: Here, we evaluated the kinetics of relapse rate in correlation with GVHD occurrence after UCBT. The kinetics of relapse rate over time in correlation to GVHD occurrence were assessed by calculating the relapse rate per patient-year within sequential 90-day intervals. The impact of GVHD on relapse and mortality was further studied in multivariate Cox models handling GVHD as a time-dependent covariate. RESULTS: The study included data from 1068 patients given single (n = 567) or double (n = 501) UCBT. The proportion of patients with grade II, III and IV acute GVHD was 20%, 7% and 4%, respectively. At 2 years, the cumulative incidence of chronic GVHD was 42%, the cumulative incidence of relapse was 32%, and overall survival was 32% as well. Relapse rates declined gradually over time during the first 30 months after transplantation. There was a possible suggestion that grade II-IV acute (HR = 0.8, P = 0.1) and chronic (HR = 0.65, P = 0.1) GVHD decreased relapse risk. However, grade II-IV acute GVHD significantly increased early (the first 18 months after UCBT) mortality (HR = 1.3, P = 0.02), whilst chronic GVHD increased each early (HR = 2.7, P < 0.001) and late (HR = 4.9, P < 0.001) mortality after UCBT. CONCLUSIONS: The occurrence of grade II-IV acute or chronic GVHD each increases overall mortality after UCBT for AML mitigating the possible graft-versus-leukemia effect of GVHD. [less ▲]

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See detailRelevant Animal Models in Dermatophyte Research
Cambier, Ludivine ULiege; Heinen, Marie-Pierre ULiege; Mignon, Bernard ULiege

in Mycopathologia (2017), 182(1), 229-240

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See detailEarliest Mississippian rugose corals of eastern Australia: post-disaster fauna across the Devonian-Carboniferous Boundary?
Denayer, Julien ULiege; Webb, Gregory

in Palaeodiversity & Palaeoenvironments (2017), 97(3), 655-667

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See detailAntiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents
Jansen, Olivia ULiege; Tchinda, Alembert T.; Loua, Jean et al

in Journal of Ethnopharmacology (2017), 203(March), 20--26

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See detailNeomelodica Music: Formal, Informal and Criminal Dimensions of Naples’ Marginalised Entertainment Industry.
Mazzola, Alessandro ULiege

in The European Review of Organised Crime (2017), 1(4), 84-105

Neapolitan neomelodica music is popular among listeners in Southern Italy and abroad. Its contents and aesthetic qualities are depicted as a sign of cultural degradation or as an expression of the ... [more ▼]

Neapolitan neomelodica music is popular among listeners in Southern Italy and abroad. Its contents and aesthetic qualities are depicted as a sign of cultural degradation or as an expression of the criminal culture characterising, as the cliché would have it, Naples’ marginalised underclass. The dominant paradigm in journalistic and criminological analyses describes its scene as mostly unprofessional and largely embedded in a mafia-run entertainment circuit through which Camorra members reinforce their popular consensus and economic domination over local communities. The aim of this article is to deconstruct this dominant view by using an ethnographic approach to analyse several case studies of neomelodica music. The pre-existing literature mostly criticises moral and cultural aspects of the phenomenon, while the public debate tends to misinterpretate and underestimate the real dimensions of neomelodica music as a professionally organised and structured cultural business. The unrecognised status of neomelodica music complicates a more articulated view of its political-economic modes of functioning and on the role played by dominant criminal actors in the field. This article concludes that, rather than being a product of an endogenous degenerate local political economy, the informal and illicit aspects of the neomelodica business can be read as the consequence of its marginalisation in the Italian cultural landscape and entertainment industry.The aim of this article is to deconstruct this dominant view by using an ethnographic approach to analyse several case studies of neomelodica music. The pre-existing literature mostly criticises moral and cultural aspects of the phenomenon, while the public debate tends to misinterpretate and underestimate the real dimensions of neomelodica music as a professionally organised and structured cultural business. The unrecognised status of neomelodica music complicates a more articulated view of its political-economic modes of functioning and on the role played by dominant criminal actors in the field. This article concludes that, rather than being a product of an endogenous degenerate local political economy, the informal and illicit aspects of the neomelodica business can be read as the consequence of its marginalisation in the Italian cultural landscape and entertainment industry. [less ▲]

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See detailDetection of a persistent meteoric metal layer in the Martian atmosphere
Crismani, M. M. J.; Schneider, N. M.; Plane, J. M. C. et al

in Nature Geoscience (2017), 10(6), 401-404

Interplanetary dust particles sporadically enter planetary atmospheres at orbital velocities and ablate as collisions occur with ambient gases to produce a persistent layer of metallic atoms (for example ... [more ▼]

Interplanetary dust particles sporadically enter planetary atmospheres at orbital velocities and ablate as collisions occur with ambient gases to produce a persistent layer of metallic atoms (for example, Fe, Mg, Na) in their upper atmospheres. Such layers are well studied at Earth, but have not been directly detected elsewhere in the Solar System. Here we report the detection of a meteoric layer consisting of Mg+ ions near an altitude of 90 km in the Martian atmosphere from ultraviolet remote sensing observations by NASA's MAVEN spacecraft. We observe temporal variability in the Mg+ layer over the course of a Martian year, moving up and down in altitude seasonally and in response to dust storms, and displaying diurnal fluctuations in density. We also find that most meteor showers do not significantly perturb this layer, which constrains the fluence of eleven observed Martian meteor showers to less than our estimated global dust flux. The persistence and variability of the Mg+ layer are difficult to explain with existing models and reconcile with other transient layers of ions observed in the Martian ionosphere. We suggest that the transient layers are not sourced from the persistent Mg+ layer and thus not derived from meteoric material, but are ambient ions produced by some unknown mechanism. © 2017 Macmillan Publishers Limited, part of Springer Nature. [less ▲]

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See detailPartial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin.
Farcas, E.; Bouckaert, C.; Servais, Anne-Catherine ULiege et al

in Analytica Chimica Acta (2017), 984

With the emergence of more challenging targets, a relatively new approach, fragment-based drug discovery (FBDD), proved its efficacy and gained increasing importance in the pharmaceutical industry. FBDD ... [more ▼]

With the emergence of more challenging targets, a relatively new approach, fragment-based drug discovery (FBDD), proved its efficacy and gained increasing importance in the pharmaceutical industry. FBDD identifies low molecular-weight (MW) ligands (fragments) that bind to biologically important macromolecules, then a structure-guided fragment growing or merging approach is performed, contributing to the quality of the lead. However, to select the appropriate fragment to be evolved, sensitive analytical screening methods must be used to measure the affinity in the muM or even mM range. In this particular context, we developed a robust and selective partial filling affinity CE (ACE) method for the direct binding screening of a small fragment library in order to identify new thrombin inhibitors. To demonstrate the accuracy of our assay, the complex dissociation constants of three known thrombin inhibitors, namely benzamidine, p-aminobenzamidine and nafamostat were determined and found to be in good concordance with the previously reported values. Finally, the screening of a small library was performed and demonstrated the high discriminatory power of our method towards weak binders compared to classical spectrophotometric activity assay, proving the interest of our method in the context of FBDD. [less ▲]

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See detailRange size heritability and diversification patterns in the liverwort genus Radula
Patiño, J.; Wang, J.; Renner, M.A.M. et al

in Molecular Phylogenetics & Evolution (2017), 106

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See detailRemembering Beyond Words: Jazz and Musicality in Caryl Phillips’s Crossing the River
Mascoli, Giulia ULiege

in Lamar Journal of the Humanities (2017), XLII(Spring), 5-22

The main focus in this article is to show why Caryl Phillips’s Crossing the River can be considered a jazz novel and specifically how its rhythmic quality is achieved. The article also seeks to develop an ... [more ▼]

The main focus in this article is to show why Caryl Phillips’s Crossing the River can be considered a jazz novel and specifically how its rhythmic quality is achieved. The article also seeks to develop an informed understanding of Phillips’s use of music in a way that reflects its significance in the postcolonial context. [less ▲]

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See detailVaginocutaneous fistula and buttock abscess formation 7 years after polypropylene transobturator tape insertion.
ABDALLAH, Alain; NISOLLE, Michelle ULiege; DE LANDSHEERE, Laurent ULiege

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2017), 46

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including ... [more ▼]

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including infections, abscess and fistula formation. Here we report a case of 57 year old female who presented with abscess and left vaginocutaneous buttock fistula 7 years after transobturator polypropelene tape insertion. Treatment included abscess drainage with dissection of the fistulous tract and removal of the left arm of the transobturator tape along with antibiotic coverage. Sinus drainage stopped after 3 days. Stress urinary incontinence didn't recur. Suspicion of fistula formation should rise in patients presenting with bothersome vaginal or cutaneous discharge after transobturator tape insertion. This case is particular since it describes a fistula complication with polypropelene tape which is unusual with this type of tapes. Treatment of such complication should always consist of surgical removal of the mesh to allow closure of the fistulous tract. [less ▲]

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See detailLa gestion de la matière organique du sol, un enjeu important pour limiter la lixiviation du nitrate vers les eaux souterraines
Vandenberghe, Christophe ULiege; Colinet, Gilles ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21

Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive ... [more ▼]

Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive (ND). This vulnerable area has a relatively high diversity of agro-soil environments. Thus, the nitrogen content of agricultural soils can vary locally by a factor 4. Objectives. This study aimed to establish whether the carbon content of a soil is a significant risk factor in nitrate leaching to groundwater. Method. The article is based on measurements of nitrate nitrogen residue (APL) and soil total organic carbon (TOC) at the beginning of the leaching period. The measurements were made in 2012 in 1,500 plots, during inspections organized by the Wallonia Public Service. This was as part of the application of the Program for the Sustainable Management of Nitrogen in Agriculture, the scheme for implementing the ND within the Walloon region. Results. Examination of the results showed both that the APL was positively correlated to the TOC and that plots with “noncompliant” APL results had a significantly higher average TOC than the other plots. Conclusions. Since APL is an environmental indicator of the risk of nitrate leaching, it appears that the TOC may constitute a risk of groundwater contamination by nitrate. It is therefore advisable to improve the inclusion of this parameter in advice regarding nitrogen fertilization and secondly, in the case of summer harvest, to better manage the sowing of catch crops. [less ▲]

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See detailDo evoked potentials contribute to the functional follow-up and clinical prognosis of multiple sclerosis?
GIFFROY, Xavier ULiege; MAES, Nathalie ULiege; Albert, Adelin ULiege et al

in Acta Neurologica Belgica (2017)

The clinical variability and complexity of multiple sclerosis (MS) challenges the individual clinical course prognostication. This study aimed to find out whether multimodal evoked potentials (EP ... [more ▼]

The clinical variability and complexity of multiple sclerosis (MS) challenges the individual clinical course prognostication. This study aimed to find out whether multimodal evoked potentials (EP) correlate with the motor components of multiple sclerosis functional composite (MSFCm) and predict clinically relevant motor functional deterioration. One hundred MS patients were assessed at baseline (T0) and about 7.5 years later (T1), with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) and the MSFCm, including the 9 Hole Peg Test and the Timed 25 Foot Walk (T25FW). The Spearman correlation coefficient (rS) was used to evaluate the cross-sectional and longitudinal relationship between EP Z scores and clinical findings. The predictive value of baseline electrophysiological data for clinical worsening (EDSS, 9-HPT, T25FW, MSFCm) during follow-up was assessed by logistic regression analysis. Unlike longitudinal correlations, cross-sectional correlations between EP Z scores and clinical outcomes were all significant and ranged between 0.22 and 0.67 (p\0.05). The global EP Z score was systematically predictive of EDSS and MSFCm worsening over time (all p\0.05). EP latency was a better predictor than amplitude, although weaker than latency and amplitude aggregation in the global EP Z score. The study demonstrates that EP numerical scores can be used for motor function monitoring and outcome prediction in patients with MS. [less ▲]

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See detailSPICAM on Mars Express: A 10 year in-depth survey of the Martian atmosphere
Montmessin, F.; Korablev, O.; Lefèvre, F. et al

in Icarus (2017), 297

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See detailL'ethnicité et ses frontières. Deuxième édition revue et mise à jour.
Martiniello, Marco ULiege

in Ethnic and Racial Studies (2017)

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See detailIntroduction de la section "Echos de la recherche"
Simons, Germain ULiege; Beckers, Jacqueline ULiege; De Croix, Séverine et al

in Didactiques en Pratique (2017), 3

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See detailLoss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.
Laguesse, Sophie; Close, Pierre ULiege; Van Hees, Laura ULiege et al

in Frontiers in Cellular Neuroscience (2017), 11

The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective ... [more ▼]

The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective alpha-tubulin acetylation. However, this complex is already expressed by cortical progenitors where it may regulate the early steps of migration by targeting additional proteins. Here we report that connexin-43 (Cx43), which is strongly expressed by cortical progenitors and whose depletion impairs projection neuron migration, requires Elongator expression for its proper acetylation. Indeed, we show that Cx43 acetylation is reduced in the cortex of Elp3cKO embryos, as well as in a neuroblastoma cell line depleted of Elp1 expression, suggesting that Cx43 acetylation requires Elongator in different cellular contexts. Moreover, we show that histones deacetylase 6 (HDAC6) is a deacetylase of Cx43. Finally, we report that acetylation of Cx43 regulates its membrane distribution in apical progenitors of the cerebral cortex. [less ▲]

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See detailLooking for a Dialogue between Farmers and Scientific Soil Knowledge: Learnings from an Ethno-Geomorphopedological Study in a Philippine’s Upland Village
Richelle, Lola; Visser, Marjolein; Bock, Laurent ULiege et al

in Agroecology and Sustainable Food Systems (2017), 0(ja),

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See detailLong-term consistency of spatial patterns of primate seed dispersal
Heymann, E. W.; Culot, Laurence ULiege; Knogge, Christoph et al

in Ecology and Evolution (2017)

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See detailIntroduction: Thinking Caryl Phillips out of the box
Ledent, Bénédicte ULiege

in Ariel : A Review of International English Literature (2017), 48(3&4), 1-11

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See detailAssessment and Retrofit of the Bridge over Kouris River, Cyprus
Maraveas, Chrysanthos ULiege; Tassiouli, Konstantina

in Open Journal of Civil Engineering (2017)

The main objective of the present study is the assessment and retrofit of an existing road bridge that is located in Cyprus over the river Kouris. In particular the study concerns in a road bridge with ... [more ▼]

The main objective of the present study is the assessment and retrofit of an existing road bridge that is located in Cyprus over the river Kouris. In particular the study concerns in a road bridge with seven spans of 10.5 m + 5 * 12.6 m + 10.5 m, a cross section width of 7.10 m and a 5 m piers height that was constructed in the early 50’s. The structural system of the bridge comprises of cast in situ reinforced concrete T-beams and slab deck that is simply supported on masonry piers. According to the new urban plan to design the bridge should now accommodate two lanes per direction, a pedestrian walkway and a cycling lane with total cross section width of new deck 15.60 m. The deck of the bridge widened using for aesthetic reasons the same cross section type and the new T-Beams and slab deck connected monolithically to the existing one. The existing part of the deck was strengthened with reinforced concrete jacketing due to inadequacy in shear resistance. Major challenge of the project posed the existing masonry pier layout that was insufficient to carry the new design seismic forces. New piers, founded on piles, were designed adjacent to the existing piers in order to support the new widened part of the bridge, and also to bear all the horizontal loads arising from the masses of the total deck. Sliding bearings (free movement) placed in the part of the bridge over the existing piers and elastomeric bearings with movement only in the longitudinal direction placed in the new piers. [less ▲]

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See detailMeeting the Needs of Mothers During the Postpartum Period: Using Co-Creation Workshops to Find Technological Solutions.
Slomian, Justine ULiege; Emonts, Patrick ULiege; Vigneron, Lara ULiege et al

in JMIR Research Protocols (2017), 6(5), 76

BACKGROUND: The postnatal period is associated with many new needs for mothers. OBJECTIVE: The aim of this study was to find technological solutions that meet the needs of mothers during the year ... [more ▼]

BACKGROUND: The postnatal period is associated with many new needs for mothers. OBJECTIVE: The aim of this study was to find technological solutions that meet the needs of mothers during the year following childbirth. METHODS: Two co-creation workshops were undertaken with parents and professionals. The aim of the first workshop was to create a list of all the criteria the proposed solution would have to address to meet the needs of mothers after childbirth. The aim of the second workshop was to create solutions in response to the criteria selected during the first workshop. RESULTS: Parents and health professionals want solutions that include empathy (ie, to help fight against the feelings of abnormality and loneliness), that help mothers in daily life, that are personalized and adapted to different situations, that are educational, and that assures some continuity in their contact with health professionals. In practice, we found that parents and professionals think the solution should be accessible to everyone and available at all times. To address these criteria, technology experts proposed different solutions, such as a forum dedicated to the postpartum period that is supervised by professionals, a centralized website, a system of videoconferencing, an online exchange group, a "gift voucher" system, a virtual reality app, or a companion robot. CONCLUSIONS: The human component seems to be very important during the postnatal period. Nevertheless, technology could be a great ally in helping mothers during the postpartum period. Technology can help reliably inform parents and may also give them the right tools to find supportive people. However, these technologies should be tested in clinical trials. [less ▲]

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See detailLabor Use and Management in Vietnamese Craft Villages: A Case Study in Tu Son Town, Bac Ninh Province
Nguyen Thi Hai Ninh, ULiege; Lebailly, Philippe ULiege

in Asian Research Journal of Business Management (2017), 4(4), 54-63

The findings of the research on 150 laborers in three craft villages show that 41.33 percent of labor are concentrated in the age group of 30-45, of these laborers men is accounted for over 57 percent ... [more ▼]

The findings of the research on 150 laborers in three craft villages show that 41.33 percent of labor are concentrated in the age group of 30-45, of these laborers men is accounted for over 57 percent, and only 26 percent are skilled labor. Most of the laborers are working in noisy and unsafe conditions, and less than 30% of them are equipped with labor protection equipment. Moreover, the prevailing salaries of laborers are from 3 to 5 million VND per month whereas the rate of labor contracted is very low (the highest is about 23% at Da Hoi), that makes labourers are less satisfied with work. In order to determine factors effecting laborer’s satisfaction with work, the authors use Exploratory Factor Analysis and the results show that Cronbach Alfa coefficient of each group is more than 0.6. That indicates the use of 30 observation variations belonging to 5 factors in the study is suitable. Additionally, logistic model reports that working conditions, income, welfare policies and gender have a statistically significant effect on job satisfaction of labourers. When the score of the importance of working condition increases 1 point, the probability of workers satisfy with their works increases 1.307 time. When the score of importance of income increases 1 point, the probability of satisfaction increases 1.494 time. When the score of importance of treatment policy increases 1 point, the probability of satisfaction increases 1.329 time. Therefore craft villages need to improve these factors in order to improve the efficiency of labour. [less ▲]

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See detailA new electron-ion coincidence 3D momentum-imaging method and its application in probing strong field dynamics of 2-phenylethyl-N, N-dimethylamine
Fan, Lin; Lee, Suk Kyoung; Tu, Yi-Jung et al

in Journal of Chemical Physics (2017), 147

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See detailPhotosynthetic productivity and its efficiencies in ISIMIP2a biome models: benchmarking for impact assessment studies
Ito, Akihiko; Nishina, Kazuya; Reyer, Christopher P. O. et al

in Environmental Research Letters (2017), 12(8), 085001

Simulating vegetation photosynthetic productivity (or gross primary production, GPP) is a critical feature of the biome models used for impact assessments of climate change. We conducted a benchmarking of ... [more ▼]

Simulating vegetation photosynthetic productivity (or gross primary production, GPP) is a critical feature of the biome models used for impact assessments of climate change. We conducted a benchmarking of global GPP simulated by eight biome models participating in the second phase of the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP2a) with four meteorological forcing datasets (30 simulations), using independent GPP estimates and recent satellite data of solar-induced chlorophyll fluorescence as a proxy of GPP. The simulated global terrestrial GPP ranged from 98 to 141 Pg C yr −1 (1981–2000 mean); considerable inter-model and inter-data differences were found. Major features of spatial distribution and seasonal change of GPP were captured by each model, showing good agreement with the benchmarking data. All simulations showed incremental trends of annual GPP, seasonal-cycle amplitude, radiation-use efficiency, and water-use efficiency, mainly caused by the CO 2 fertilization effect. The incremental slopes were higher than those obtained by remote sensing studies, but comparable with those by recent atmospheric observation. Apparent differences were found in the relationship between GPP and incoming solar radiation, for which forcing data differed considerably. The simulated GPP trends co-varied with a vegetation structural parameter, leaf area index, at model-dependent strengths, implying the importance of constraining canopy properties. In terms of extreme events, GPP anomalies associated with a historical El Niño event and large volcanic eruption were not consistently simulated in the model experiments due to deficiencies in both forcing data and parameterized environmental responsiveness. Although the benchmarking demonstrated the overall advancement of contemporary biome models, further refinements are required, for example, for solar radiation data and vegetation canopy schemes. [less ▲]

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See detailFinancial Impacts of Priority Swine Diseases to Pig Farmers in Red River and Mekong River Delta, Vietnam.
Pham, T. T. Hoa; Antoine-Moussiaux, Nicolas ULiege; Grosbois, V. et al

in Transboundary and Emerging Diseases (2017)

A study was conducted between May 2013 and August 2014 in three provinces of Vietnam to investigate financial impacts of swine diseases in pig holdings in 2010-2013. The aim of the study was to quantify ... [more ▼]

A study was conducted between May 2013 and August 2014 in three provinces of Vietnam to investigate financial impacts of swine diseases in pig holdings in 2010-2013. The aim of the study was to quantify the costs of swine diseases at producer level in order to understand swine disease priority for monitoring at local level. Financial impacts of porcine reproductive and respiratory syndrome (PRRS), foot and mouth disease (FMD), and epidemic diarrhoea were assessed for 162 pig holders in two Red River Delta provinces and in one Mekong River Delta province, using data on pig production and swine disease outbreaks at farms. Losses incurred by swine diseases were estimated, including direct losses due to mortality (100% market value of pig before disease onset) and morbidity (abortion, delay of finishing stage), and indirect losses due to control costs (treatment, improving biosecurity and emergency vaccination) and revenue foregone (lower price in case of emergency selling). Financial impacts of swine diseases were expressed as percentage of gross margin of pig holding. The gross margin varied between pig farming groups (P < 0.0001) in the following order: large farm (USD 18 846), fattening farm (USD 7014) and smallholder (USD 2350). The losses per pig holding due to PRRS were the highest: 41% of gross margin for large farm, 38% for fattening farm and 63% for smallholder. Cost incurred by FMD was lower with 19%, 25% and 32% of gross margin of pig holding in large farm, fattening farm and smallholder, respectively. The cost of epidemic diarrhoea was the lowest compared to losses due to PRRS and FMD and accounted for around 10% of gross margin of pig holding in the three pig farming groups. These estimates provided critical elements on swine disease priorities to better inform surveillance and control at both national and local level. [less ▲]

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See detailWalnut husk fly, Rhagoletis completa (Diptera: Tephritidae), invades Europe: invasion potential and control strategies
Verheggen, François ULiege; Verhaeghe, Agnès; Giordanengo, Philippe et al

in Applied Entomology and Zoology (2017), 52(1), 1-7

Rhagoletis completa Cresson (Diptera: Tephritidae) is native to North America and invaded Western Europe in the late 1980s, causing important damage to its principal host, walnut (Juglans spp.). In this ... [more ▼]

Rhagoletis completa Cresson (Diptera: Tephritidae) is native to North America and invaded Western Europe in the late 1980s, causing important damage to its principal host, walnut (Juglans spp.). In this review, we summarize the important elements of R. completa’s biology, phytosanitary status and methods used in Europe for its control, and then present the main conclusions associated with a completed risk analysis performed in 2014 to evaluate the dispersion and establishment potential of R. completa in Europe. The walnut husk fly was initially identified in Switzerland (1988) and Italy (1991), from where it spread to at least seven additional countries: France, Spain, Germany, Austria, Croatia, Slovenia and Hungary. R. completa has not reached the limits of its potential distribution. The main dissemination pathways within Europe include: (1) natural adult dissemination; (2) adult hitchhiker behaviour; and, to a lesser extent, (3) transportation of larvae in fresh fruits. R. completa host plants are widely distributed in Europe, either as isolated wild trees or in orchards, favouring the probability of fly establishment in currently fly-free areas. In addition, the European territories where Juglans species are present share biogeographic similarities. In orchards where R. completa is present and uncontrolled, 100% of walnut trees can be infested, causing losses in walnut yields of up to 80%. The negative effect is low (<10% yield loss) under phytosanitary control, although additional costs must also be considered to support specific monitoring for R. completa. The information presented here underlines a strong need for better walnut husk fly monitoring across European countries, as well as for increasing efforts to develop biological methods to control this emerging pest. [less ▲]

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