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See detailDesign of hybrid nanovehicles for remotely triggered drug release: an overview
Liu, Ji; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Materials Chemistry B (2015), 3(30), 6117-6147

n the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote ... [more ▼]

n the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote stimuli, e.g. alternating magnetic field, near infrared or ultrasound radiations, the release of guest molecules can be triggered in a quite controlled manner. Herein, we review different hybrid nanostructures which have already been reported for the remotely triggered release, such as those based on (1) host–guest conjugates, (2) core–corona nanoparticles, (3) polymer nanogels, (4) polymer micelles, (5) liposomes, (6) mesoporous silica particles and (7) hollow nanoparticles. Moreover, we also summarize six underlying mechanisms that govern such a kind of remotely triggered release behaviours: (1) enhanced diffusion and/or permeation, (2) thermo- or photo-labile bond cleavage, (3) fusion of phase-changed materials, (4) photo-induced isomerisation, (5) thermo-induced swelling/de-swelling of thermo-responsive polymers, and (6) destruction of the nanostructures. The ways in which different components are incorporated into an integrated hybrid nanostructure and how they contribute to the remotely triggered release behaviours are detailed. [less ▲]

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See detailInterlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping
Wenz, Christian; Barbas, Coral; Lopez-Gonzalvez, Angeles et al

in Journal of Separation Science (2015)

A collaborative study on the robustness and portability of a capillary electrophoresis-mass spectrometry method for peptide mapping was performed by an international team, consisting of 13 independent ... [more ▼]

A collaborative study on the robustness and portability of a capillary electrophoresis-mass spectrometry method for peptide mapping was performed by an international team, consisting of 13 independent laboratories from academia and industry. All participants used the same batch of samples, reagents and coated capillaries to run their assays, whereas they utilized the capillary electrophoresis-mass spectrometry equipment available in their laboratories. The equipment used varied in model, type and instrument manufacturer. Furthermore, different types of sheath-flow capillary electrophoresis–mass spectrometry interfaces were used. Migration time, peak height and peak area of ten representative target peptides of trypsin-digested bovine serum albumin were determined by every laboratory on two consecutive days. The data were critically evaluated to identify outliers and final values for means, repeatability (precision within a laboratory) and reproducibility (precision between laboratories) were established. For relative migration time the repeatability was between 0.05 and 0.18% RSD and the reproducibility between 0.14 and 1.3% RSD. For relative peak area repeatability and reproducibility values obtained were 3–12 and 9–29% RSD, respectively. These results demonstrate that capillary electrophoresis-mass spectrometry is robust enough to allow a method transfer across multiple laboratories and should promote a more widespread use of peptide mapping and other capillary electrophoresis-mass spectrometry applications in biopharmaceutical analysis and related fields. [less ▲]

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See detailAll Poly(ionic liquid)-based block copolymers by sequential controlled radical copolymerization of vinylimidazolium monomers
Cordella, Daniela ULg; Kermagoret, Anthony; Debuigne, Antoine ULg et al

in Macromolecules (2015), 48(15), 5230-5243

The organometallic-mediated radical polymerization (OMRP) of N-vinyl-3-alkylimidazolium-type monomers, featuring the bis(trifluoromethylsulfonyl)imide counteranion (Tf2N–), in the presence of Co(acac)2 as ... [more ▼]

The organometallic-mediated radical polymerization (OMRP) of N-vinyl-3-alkylimidazolium-type monomers, featuring the bis(trifluoromethylsulfonyl)imide counteranion (Tf2N–), in the presence of Co(acac)2 as controlling agent, is reported. Polymerizations of monomers with methyl, ethyl, and butyl substituents are fast, reaching high monomer conversion in ethyl acetate as solvent at 30 °C, and afford structurally well-defined hydrophobic poly(ionic liquid)s (PILs) of N-vinyl type. Block copolymer synthesis is also achieved by sequential OMRP of N-vinyl-3-alkylimidazolium salts carrying different alkyl chains and different counteranions (Tf2N– or Br–). These block copolymerizations are carried out at 30 °C, either under homogeneous solution in methanol or in a biphasic medium consisting of a mixture of ethyl acetate and water. Unprecedented PIL-b-PIL block copolymers are thus prepared under these conditions. However, anion exchange occurs at the early stage of the growth of the second block. Finally, diblock copolymers generated in the biphasic medium can be readily coupled by addition of isoprene, forming all PIL-based and symmetrical ABA-type triblock copolymers in a one-pot process. Such a direct block copolymerization method, involving vinylimidazolium monomers bearing different alkyl chains, thus opens new opportunities in the precision synthesis of all PIL-based block copolymers of tunable properties. [less ▲]

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See detailRecent changes in north-west Greenland climate documented by NEEM shallow ice core data and simulations, and implications for past-temperature reconstructions
Masson-Delmotte, V.; Steen-Larsen, H.; Ortega, P. et al

in Cryosphere (The) (2015), 9

Combined records of snow accumulation rate, δ18O and deuterium excess were produced from several shallow ice cores and snow pits at NEEM (North Greenland Eemian Ice Drilling), covering the period from ... [more ▼]

Combined records of snow accumulation rate, δ18O and deuterium excess were produced from several shallow ice cores and snow pits at NEEM (North Greenland Eemian Ice Drilling), covering the period from 1724 to 2007. They are used to investigate recent climate variability and characterise the isotope–temperature relationship. We find that NEEM records are only weakly affected by inter-annual changes in the North Atlantic Oscillation. Decadal δ18O and accumulation variability is related to North Atlantic sea surface temperature and is enhanced at the beginning of the 19th century. No long-term trend is observed in the accumulation record. By contrast, NEEM δ18O shows multidecadal increasing trends in the late 19th century and since the 1980s. The strongest annual positive δ18O values are recorded at NEEM in 1928 and 2010, while maximum accumulation occurs in 1933. The last decade is the most enriched in δ18O (warmest), while the 11-year periods with the strongest depletion (coldest) are depicted at NEEM in 1815–1825 and 1836–1846, which are also the driest 11-year periods. The NEEM accumulation and δ18O records are strongly correlated with outputs from atmospheric models, nudged to atmospheric reanalyses. Best performance is observed for ERA reanalyses. Gridded temperature reconstructions, instrumental data and model outputs at NEEM are used to estimate the multidecadal accumulation–temperature and δ18O–temperature relationships for the strong warming period in 1979–2007. The accumulation sensitivity to temperature is estimated at 11 ± 2 % °C−1 and the δ18O–temperature slope at 1.1 ± 0.2 ‰ °C−1, about twice as large as previously used to estimate last interglacial temperature change from the bottom part of the NEEM deep ice core. [less ▲]

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See detailLa lutte contre les moustiques (Diptera: Culicidae): diversité des approches et application du contrôle biologique
Bawin, Thomas ULg; Seye, Fawrou; Boukraa, Slimane ULg et al

in Canadian Entomologist (2015), 147(4), 476-500

Many mosquito (Diptera: Culicidae) species are zoonotic vectors responsible for numerous infectious diseases of medical and veterinary importance. Currently, changes in the vectors’ geographical ... [more ▼]

Many mosquito (Diptera: Culicidae) species are zoonotic vectors responsible for numerous infectious diseases of medical and veterinary importance. Currently, changes in the vectors’ geographical distribution induced chiefly by anthropogenic factors are accompanied by emerging and reemerging infectious diseases in Europe and North America. Since the advent of synthetic insecticides during the Second World War, mosquitoes are the object of considerably expanded and deepened research. In an integrated pest management context, means of control are now mainly classified as: (1) environmental management and physical control, (2) chemical control, (3) genetic control, and (4) biological control by means of entomophagous predators and entomopathogenic microorganisms. In this context, these last have significant potential because of their ability to infect and kill their host with more or less targeted selectivity. This article proposes to emphasize biological control among other techniques in mosquito control, and to assess the potential and the opportunities offered by entomopathogenic bacteria, viruses and fungi. Finally, their use as biopesticides is discussed. [less ▲]

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See detailGenome-wide hydroxymethylcytosine pattern changes in response to oxidative stress.
Delatte, Benjamin; Jeschke, Jana; Defrance, Matthieu et al

in Scientific reports (2015), 5

The TET enzymes convert methylcytosine to the newly discovered base hydroxymethylcytosine. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains ... [more ▼]

The TET enzymes convert methylcytosine to the newly discovered base hydroxymethylcytosine. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain, and results lack in vivo models. Here we show a global decrease of hydroxymethylcytosine in cells treated with buthionine sulfoximine, and in mice depleted for the major antioxidant enzymes GPx1 and 2. Furthermore, genome-wide profiling revealed differentially hydroxymethylated regions in coding genes, and intriguingly in microRNA genes, both involved in response to oxidative stress. These results thus suggest a profound effect of in vivo oxidative stress on the global hydroxymethylome. [less ▲]

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See detailModels of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints
Lagarde, N.; Miglio, A.; Eggenberger, P. et al

in Astronomy and Astrophysics (2015), 580

Context. The availability of asteroseismic constraints for a large sample of red giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of ... [more ▼]

Context. The availability of asteroseismic constraints for a large sample of red giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations. <BR /> Aims: We use a detailed spectroscopic study of 19 CoRoT red giant stars to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars. <BR /> Methods: In order to explore the effects of rotation-induced mixing and thermohaline instability, we compare surface abundances of carbon isotopic ratio and lithium with stellar evolution predictions. These chemicals are sensitive to extra-mixing on the red giant branch. <BR /> Results: We estimate mass, radius, and distance for each star using the seismic constraints. We note that the Hipparcos and seismic distances are different. However, the uncertainties are such that this may not be significant. Although the seismic distances for the cluster members are self consistent they are somewhat larger than the Hipparcos distance. This is an issue that should be considered elsewhere. Models including thermohaline instability and rotation-induced mixing, together with the seismically determined masses can explain the chemical properties of red giant targets. However, with this sample of stars we cannot perform stringent tests of the current stellar models. Tighter constraints on the physics of the models would require the measurement of the core and surface rotation rates, and of the period spacing of gravity-dominated mixed modes. A larger number of stars with longer times series, as provided by Kepler or expected with Plato, would help ensemble asteroseismology. [less ▲]

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See detailWhat effects do rater bias and assessment method haveon disease severity estimation with regard to hypothesis testing?
Chiang, Kuo-Szu; Bock, Clive; El Jarroudi, Moussa ULg et al

in Plant Pathology (2015)

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See detailHigh-resolution spectra of comet C/2013 R1 (Lovejoy)
Rousselot, P.; Decock, A.; Korsun, P. P. et al

in Astronomy and Astrophysics (2015), 580

Context. High-resolution spectra of comets permit deriving the physical properties of the coma. In the optical range, relative production rates can be computed, and information about isotopic ratios and ... [more ▼]

Context. High-resolution spectra of comets permit deriving the physical properties of the coma. In the optical range, relative production rates can be computed, and information about isotopic ratios and the origin of oxygen atoms can be obtained. <BR /> Aims: The main objective of the work presented here was to obtain information about the chemical composition of comet C/2013 R1 (Lovejoy), a bright and long-period comet that passed perihelion (0.81 au) on 22 December 2013. <BR /> Methods: We used the HARPS-North echelle spectrograph at the 3.5 m telescope TNG to obtain high-resolution spectra of comet C/2013 R1 (Lovejoy) in the optical range immediately after its perihelion passage during four consecutive nights in the period December 23 to 26, 2013. <BR /> Results: Our results demonstrate the ability of HARPS-North to efficiently obtain cometary spectra. Very faint emission lines, such as those of [SUP]15[/SUP]NH[SUB]2[/SUB], have been detected, leading to a rough estimate of the [SUP]14[/SUP]N/[SUP]15[/SUP]N ratio in NH[SUB]2[/SUB]. The [SUP]12[/SUP]C/[SUP]13[/SUP]C ratio was measured in the C[SUB]2[/SUB] lines and is equal to 80 ± 30. The oxygen lines were studied as well (green to red line intensity ratios and widths), confirming that H[SUB]2[/SUB]O is the main parent molecule that photodissociates to produce oxygen atoms. This suggests that this comet has a high CO[SUB]2[/SUB] abundance. Relative production rates for C[SUB]2[/SUB] and NH[SUB]2[/SUB] were computed, but we found no significant deviation from a typical NH[SUB]2[/SUB]/C[SUB]2[/SUB] ratio. Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. [less ▲]

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See detailA Coordinated X-Ray and Optical Campaign of the Nearest Massive Eclipsing Binary, δ Orionis Aa. I. Overview of the X-Ray Spectrum
Corcoran, M. F.; Nichols, J. S.; Pablo, H. et al

in Astrophysical Journal (2015), 809

We present an overview of four deep phase-constrained Chandra HETGS X-ray observations of δ Ori A. Delta Ori A is actually a triple system that includes the nearest massive eclipsing spectroscopic binary ... [more ▼]

We present an overview of four deep phase-constrained Chandra HETGS X-ray observations of δ Ori A. Delta Ori A is actually a triple system that includes the nearest massive eclipsing spectroscopic binary, δ Ori Aa, the only such object that can be observed with little phase-smearing with the Chandra gratings. Since the fainter star, δ Ori Aa2, has a much lower X-ray luminosity than the brighter primary (δ Ori Aa1), δ Ori Aa provides a unique system with which to test the spatial distribution of the X-ray emitting gas around δ Ori Aa1 via occultation by the photosphere of, and wind cavity around, the X-ray dark secondary. Here we discuss the X-ray spectrum and X-ray line profiles for the combined observation, having an exposure time of nearly 500 ks and covering nearly the entire binary orbit. The companion papers discuss the X-ray variability seen in the Chandra spectra, present new space-based photometry and ground-based radial velocities obtained simultaneously with the X-ray data to better constrain the system parameters, and model the effects of X-rays on the optical and UV spectra. We find that the X-ray emission is dominated by embedded wind shock emission from star Aa1, with little contribution from the tertiary star Ab or the shocked gas produced by the collision of the wind of Aa1 against the surface of Aa2. We find a similar temperature distribution to previous X-ray spectrum analyses. We also show that the line half-widths are about 0.3‑0.5 times the terminal velocity of the wind of star Aa1. We find a strong anti-correlation between line widths and the line excitation energy, which suggests that longer-wavelength, lower-temperature lines form farther out in the wind. Our analysis also indicates that the ratio of the intensities of the strong and weak lines of Fe xvii and Ne x are inconsistent with model predictions, which may be an effect of resonance scattering. [less ▲]

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See detailThe Airline Container Loading Problem with Pickup and Delivery
Lurkin, Virginie ULg; Schyns, Michael ULg

in European Journal of Operational Research (2015), 244(3), 955-965

This paper considers the loading optimization problem for a set of containers and pallets transported into a cargo aircraft that serves multiple airports. Because of pickup and delivery operations that ... [more ▼]

This paper considers the loading optimization problem for a set of containers and pallets transported into a cargo aircraft that serves multiple airports. Because of pickup and delivery operations that occur at intermediate airports, this problem is simultaneously a Weight & Balance Problem and a Sequencing Problem. Our objective is to minimize fuel and handling operation costs. This problem is shown to be NP-hard. We resort to a mixed integer linear program. Based on real-world data from a professional partner (TNT Airways), we perform numerical experiments using a standard B&C library. This approach yields better solutions than traditional manual planning, which results in substantial cost savings. [less ▲]

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See detailOptical study of diffraction grating/Fresnel lens combinations applied to a spectral-splitting solar concentrator for space applications
Michel, Céline ULg; Loicq, Jerôme ULg; Thibert, Tanguy ULg et al

in Applied Optics (2015), 54(22), 6666-6673

This paper presents a new design of a planar solar concentrator with spectral splitting of light for space applications. This concentrator spectrally splits the incident light into mainly two parts. Each ... [more ▼]

This paper presents a new design of a planar solar concentrator with spectral splitting of light for space applications. This concentrator spectrally splits the incident light into mainly two parts. Each part is then focused onto specific spatially separated photovoltaic cells, allowing for independent control of respective cells output power. These advantages of both spectral splitting and light focusing are here combined thanks to a specific diffraction grating superimposed on a Fresnel lens. The theoretical principle of the optical design is presented, with optimization of each element and improvement steps, including optimization of grating period evolution along the lens, and testing of two kinds of gratings (a blazed and a lamellar one). First numerical results are presented, highlighting the possibility to design a concentrator at about 10× or more for each cell, with an output power larger than that of a classical concentrator focusing on a GaAs SJ cell, and less than 10% of losses for tracking errors up to ±0.8°. Some experimental results are also presented. [less ▲]

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See detailA Coordinated X-Ray and Optical Campaign of the Nearest Massive Eclipsing Binary, δ Orionis Aa. III. Analysis of Optical Photometric (MOST) and Spectroscopic (Ground-based) Variations
Pablo, Herbert; Richardson, Noel D.; Moffat, Anthony F. J. et al

in Astrophysical Journa (2015), 809

We report on both high-precision photometry from the Microvariability and Oscillations of Stars (MOST) space telescope and ground-based spectroscopy of the triple system δ Ori A, consisting of a binary O9 ... [more ▼]

We report on both high-precision photometry from the Microvariability and Oscillations of Stars (MOST) space telescope and ground-based spectroscopy of the triple system δ Ori A, consisting of a binary O9.5II+early-B (Aa1 and Aa2) with P = 5.7 days, and a more distant tertiary (O9 IV P\gt 400 years). This data was collected in concert with X-ray spectroscopy from the Chandra X-ray Observatory. Thanks to continuous coverage for three weeks, the MOST light curve reveals clear eclipses between Aa1 and Aa2 for the first time in non-phased data. From the spectroscopy, we have a well-constrained radial velocity (RV) curve of Aa1. While we are unable to recover RV variations of the secondary star, we are able to constrain several fundamental parameters of this system and determine an approximate mass of the primary using apsidal motion. We also detected second order modulations at 12 separate frequencies with spacings indicative of tidally influenced oscillations. These spacings have never been seen in a massive binary, making this system one of only a handful of such binaries that show evidence for tidally induced pulsations. [less ▲]

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See detailA Coordinated X-Ray and Optical Campaign of the Nearest Massive Eclipsing Binary, δ Orionis Aa. II. X-Ray Variability
Nichols, J.; Huenemoerder, D. P.; Corcoran, M. F. et al

in Astrophysical Journal (2015), 809

We present time-resolved and phase-resolved variability studies of an extensive X-ray high-resolution spectral data set of the δ Ori Aa binary system. The four observations, obtained with Chandra ACIS ... [more ▼]

We present time-resolved and phase-resolved variability studies of an extensive X-ray high-resolution spectral data set of the δ Ori Aa binary system. The four observations, obtained with Chandra ACIS HETGS, have a total exposure time of ≈ 479 ks and provide nearly complete binary phase coverage. Variability of the total X-ray flux in the range of 5–25 Å is confirmed, with a maximum amplitude of about ±15% within a single ≈ 125 ks observation. Periods of 4.76 and 2.04 days are found in the total X-ray flux, as well as an apparent overall increase in the flux level throughout the nine-day observational campaign. Using 40 ks contiguous spectra derived from the original observations, we investigate the variability of emission line parameters and ratios. Several emission lines are shown to be variable, including S xv, Si xiii, and Ne ix. For the first time, variations of the X-ray emission line widths as a function of the binary phase are found in a binary system, with the smallest widths at ϕ = 0.0 when the secondary δ Ori Aa2 is at the inferior conjunction. Using 3D hydrodynamic modeling of the interacting winds, we relate the emission line width variability to the presence of a wind cavity created by a wind–wind collision, which is effectively void of embedded wind shocks and is carved out of the X-ray-producing primary wind, thus producing phase-locked X-ray variability. Based on data from the Chandra X-ray Observatory and the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon Inc., the University of Toronto Institute of Aerospace Studies, and the University of British Columbia, with the assistance of the University of Vienna. [less ▲]

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See detailA Coordinated X-Ray and Optical Campaign of the Nearest Massive Eclipsing Binary, δ Orionis Aa. IV. A Multiwavelength, Non-LTE Spectroscopic Analysis
Shenar, T.; Oskinova, L.; Hamann, W.-R. et al

in Astrophysical Journal (2015), 809

Eclipsing systems of massive stars allow one to explore the properties of their components in great detail. We perform a multi-wavelength, non-LTE analysis of the three components of the massive multiple ... [more ▼]

Eclipsing systems of massive stars allow one to explore the properties of their components in great detail. We perform a multi-wavelength, non-LTE analysis of the three components of the massive multiple system δ Ori A, focusing on the fundamental stellar properties, stellar winds, and X-ray characteristics of the system. The primary’s distance-independent parameters turn out to be characteristic for its spectral type (O9.5 II), but usage of the Hipparcos parallax yields surprisingly low values for the mass, radius, and luminosity. Consistent values follow only if δ Ori lies at about twice the Hipparcos distance, in the vicinity of the σ-Orionis cluster. The primary and tertiary dominate the spectrum and leave the secondary only marginally detectable. We estimate the V-band magnitude difference between primary and secondary to be {{Δ }}V≈ 2\buildrel{{m}}\over{.} 8. The inferred parameters suggest that the secondary is an early B-type dwarf (≈B1 V), while the tertiary is an early B-type subgiant (≈B0 IV). We find evidence for rapid turbulent velocities (∼200 km s[SUP]‑1[/SUP]) and wind inhomogeneities, partially optically thick, in the primary’s wind. The bulk of the X-ray emission likely emerges from the primary’s stellar wind ({log}{L}[SUB]{{X[/SUB]}}/{L}[SUB]{Bol[/SUB]}≈ -6.85), initiating close to the stellar surface at {R}[SUB]0[/SUB]∼ 1.1 {R}[SUB]*[/SUB]. Accounting for clumping, the mass-loss rate of the primary is found to be {log}\dot{M}≈ -6.4 ({M}[SUB]ȯ [/SUB] {{yr}}[SUP]-1[/SUP]), which agrees with hydrodynamic predictions, and provides a consistent picture along the X-ray, UV, optical, and radio spectral domains. [less ▲]

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See detailImpact of ηEarth on the Capabilities of Affordable Space Missions to Detect Biosignatures on Extrasolar Planets
Léger, Alain; Defrère, Denis; Malbet, Fabien et al

in Astrophysical Journal (2015), 808

We present an analytic model to estimate the capabilities of space missions dedicated to the search for biosignatures in the atmosphere of rocky planets located in the habitable zone of nearby stars ... [more ▼]

We present an analytic model to estimate the capabilities of space missions dedicated to the search for biosignatures in the atmosphere of rocky planets located in the habitable zone of nearby stars. Relations between performance and mission parameters, such as mirror diameter, distance to targets, and radius of planets, are obtained. Two types of instruments are considered: coronagraphs observing in the visible, and nulling interferometers in the thermal infrared. Missions considered are: single-pupil coronagraphs with a 2.4 m primary mirror, and formation-flying interferometers with 4 × 0.75 m collecting mirrors. The numbers of accessible planets are calculated as a function of η[SUB]Earth[/SUB]. When Kepler gives its final estimation for η[SUB]Earth[/SUB], the model will permit a precise assessment of the potential of each instrument. Based on current estimations, η[SUB]Earth[/SUB] = 10% around FGK stars and 50% around M stars, the coronagraph could study in spectroscopy only ∼1.5 relevant planets, and the interferometer ∼14.0. These numbers are obtained under the major hypothesis that the exozodiacal light around the target stars is low enough for each instrument. In both cases, a prior detection of planets is assumed and a target list established. For the long-term future, building both types of spectroscopic instruments, and using them on the same targets, will be the optimal solution because they provide complementary information. But as a first affordable space mission, the interferometer looks the more promising in terms of biosignature harvest. [less ▲]

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See detailA force sensor based on three weakly coupled resonators with ultrahigh sensitivity
Zhao, Chun; Wood, Graham; Xie, J.B. et al

in Sensors and Actuators. A, Physical (2015), 232

A proof-of-concept force sensor based on three degree-of-freedom (DoF) weakly coupled resonatorswas fabricated using a silicon-on-insulator (SOI) process and electrically tested in 20 Torr vacuum.Compared ... [more ▼]

A proof-of-concept force sensor based on three degree-of-freedom (DoF) weakly coupled resonatorswas fabricated using a silicon-on-insulator (SOI) process and electrically tested in 20 Torr vacuum.Compared to the conventional single resonator force sensor with frequency shift as output, by measuringthe amplitude ratio of two of the three resonators, the measured force sensitivity of the 3DoF sensor was4.9 × 106/N, which was improved by two orders magnitude. A bias stiffness perturbation was applied toavoid mode aliasing effect and improve the linearity of the sensor. The noise floor of the amplitude ratiooutput of the sensor was theoretically analyzed for the first time, using the transfer function model ofthe 3DoF weakly coupled resonator system. It was shown based on measurement results that the outputnoise was mainly due to the thermal–electrical noise of the interface electronics. The output noise spectraldensity was measured, and agreed well with theoretical estimations. The noise floor of the force sensoroutput was estimated to be approximately 1.39nN for an assumed 10 Hz bandwidth of the output signal,resulting in a dynamic range of 74.8 dB. [less ▲]

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See detailTime series of high-resolution spectra of SN 2014J observed with the TIGRE telescope
Jack, D.; Mittag, M.; Schröder, K.-P. et al

in Monthly Notices of the Royal Astronomical Society (2015), 451

We present a time series of high-resolution spectra of the Type Ia supernova 2014J, which exploded in the nearby galaxy M82. The spectra were obtained with the HEROS échelle spectrograph installed at the ... [more ▼]

We present a time series of high-resolution spectra of the Type Ia supernova 2014J, which exploded in the nearby galaxy M82. The spectra were obtained with the HEROS échelle spectrograph installed at the 1.2-m TIGRE telescope. We present a series of 33 spectra with a resolution of R ≈ 20 000, which covers the important bright phases in the evolution of SN 2014J during the period from 2014 January 24 to April 1. The spectral evolution of SN 2014J is derived empirically. The expansion velocities of the Si II P-Cygni features were measured and show the expected decreasing behaviour, beginning with a high velocity of 14 000 km s[SUP]-1[/SUP] on January 24. The Ca II infrared triplet feature shows a high-velocity component with expansion velocities of >20 000 km s[SUP]-1[/SUP] during the early evolution apart from the normal component showing similar velocities as Si II. Further broad P-Cygni profiles are exhibited by the principal lines of Ca II, Mg II and Fe II. The TIGRE SN 2014J spectra also resolve several very sharp Na I D doublet absorption components. Our analysis suggests interesting substructures in the interstellar medium of the host galaxy M82, as well as in our Milky Way, confirming other work on this SN. We were able to identify the interstellar absorption of M82 in the lines of Ca II H & K at 3933 and 3968 Å as well as K I at 7664 and 7698 Å. Furthermore, we confirm several diffuse interstellar bands, at wavelengths of 6196, 6283, 6376, 6379and 6613 Å and give their measured equivalent widths. [less ▲]

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See detailDisease Severity Estimates – Effects of Rater Accuracy and Assessment Methods for Comparing Treatments
Bock, Clive; El Jarroudi, Moussa ULg; Kouadio, Louis et al

in Plant Disease (2015), 99(1104-1112),

Assessment of disease severity is required for several purposes in plant pathology; most often the estimates are made visually. It is established that visual estimates can be inaccurate and unreliable ... [more ▼]

Assessment of disease severity is required for several purposes in plant pathology; most often the estimates are made visually. It is established that visual estimates can be inaccurate and unreliable. The ramifications of biased or imprecise estimates by raters have not been fully explored using empirical data; partly because of the logistical difficulties involved in different raters assessing the same leaves for which actual disease has been measured in a replicated experiment with multiple treatments. In this study nearest percent estimates (NPEs) of Septoria leaf blotch (SLB) on leaves of winter wheat from non-treated and fungicide treated plots were assessed in both 2006 and 2007 by four raters and compared to assumed true values measured using image analysis. Lin’s concordance correlation (LCC, ρc) was used to assess agreement between the two approaches. NPEs were converted to Horsfall-Barratt (HB) mid-points and again compared for agreement with true values. The estimates of SLB severity from fungicide-treated and non-treated plots were analyzed using generalized linear mixed modeling to ascertain effects of rater using both the NPE and HB values. Rater 1 showed good agreement with image analysis (ρc = 0.986 to 0.999), while raters 3 and 4 had less good agreement (ρc = 0.205 to 0.936). Conversion to the HB scale had little effect on bias or accuracy, but reduced both precision and agreement for most raters on most assessment dates (precision, r = -0.001 to -0.132; and agreement, ρc = -0.003 to -0.468). Inter-rater reliability was also reduced slightly by conversion of estimates to HB midpoint values. Estimates of mean SLB severity were significantly different between image analysis and raters 2, 3 and 4, and there were frequently significant differences among raters (F=151 to 1260, P=0.001 to <0.0001). Conversion to the HB scale changed the means separation ranking of rater estimates on 26 June 2007. Nonetheless, image analysis and all raters were able to differentiate control and treated plots treatments (F=116 to 1952, P=0.002 to <0.0001, depending on date and rater). Conversion of NPEs to the HB scale tended to reduce F-values slightly (2006: NPEs, F=116 to 276, P=0.002 to 0.0005, and for the HB converted values F=101 to 270, P=0.002 to 0.0005, and in 2007, NPEs, F=164 to 1952 P=0.001 to <0.0001, and for HB converted values F=126 to 1633 P=0.002 to <0.0001). The results demonstrated the need for accurate and reliable disease assessment to minimize over or underestimates compared to actual disease, and where multiple raters are deployed, they should be assigned in a manner to reduce any potential effect of rater differences on the analysis. [less ▲]

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See detailSimultaneous X-ray and optical spectroscopy of the Oef supergiant λ Cephei
Rauw, Grégor ULg; Hervé, A.; Nazé, Yaël ULg et al

in Astronomy and Astrophysics (2015), 580

Probing the structures of stellar winds is of prime importance for the understanding of massive stars. Based on their optical spectral morphology and variability, it has been suggested that the stars in ... [more ▼]

Probing the structures of stellar winds is of prime importance for the understanding of massive stars. Based on their optical spectral morphology and variability, it has been suggested that the stars in the Oef class feature large-scale structures in their wind. High-resolution X-ray spectroscopy and time-series of X-ray observations of presumably single O-type stars can help us understand the physics of their stellar winds. We have collected XMM-Newton observations and coordinated optical spectroscopy of the O6 Ief star λ Cep to study its X-ray and optical variability and to analyse its high-resolution X-ray spectrum. We investigate the line profile variability of the He ii λ 4686 and Hα emission lines in our time series of optical spectra, including a search for periodicities. We further discuss the variability of the broadband X-ray flux and analyse the high-resolution spectrum of λ Cep using line-by-line fits as well as a code designed to fit the full high-resolution X-ray spectrum consistently. During our observing campaign, the He ii λ 4686 line varies on a timescale of ~18 h. On the contrary, the Hα line profile displays a modulation on a timescale of 4.1 days which is likely the rotation period of the star. The X-ray flux varies on timescales of days and could in fact be modulated by the same 4.1-day period as Hα, although both variations are shifted in phase. The high-resolution X-ray spectrum reveals broad and skewed emission lines as expected for the X-ray emission from a distribution of wind-embedded shocks. Most of the X-ray emission arises within less than 2 R∗ above the photosphere. The properties of the X-ray emission of λ Cep generally agree with the expectations of the wind-embedded shock model. There is mounting evidence for the existence of large-scale structures that modulate the Hα line and about 10% of the X-ray emission of λ Cep. [less ▲]

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See detailPreovulatory follicle diameter, growth rate and time of ovulation during induced oestrus using a CIDR® in trypanotolerant female Bos taurus N'Dama cattle.
Okouyi, M'foumou W'otari Marcel; Drion, Pierre ULg; Hanzen, Christian ULg

in Tropical Animal Health and Production (2015), 47

The aim of this study was to assess the dose (300 to 600 IU) effects of equine Chorionic Gonadotropin (eCG) on the preovulatory follicle diameter, growth rate, and time of ovulation characterized by ... [more ▼]

The aim of this study was to assess the dose (300 to 600 IU) effects of equine Chorionic Gonadotropin (eCG) on the preovulatory follicle diameter, growth rate, and time of ovulation characterized by echography. The eCG was injected at the end (D0) of the 7-day treatment with a controlled internal device release (CIDR) and a PGF2a being injected 2 days before the removal of the CIDR (D-2). The 120 female N'Dama cattle were distributed into five experimental groups. The control group (n = 26) was treated with physiological saline at the removal of the CIDR®, while the animals in the four treated groups received, respectively, 300 IU (n = 25), 400 IU (n = 24), 500 IU (n = 22) and 600 IU (n = 23) of eCG (Folligon®). Follicle growth rate (FGR) was significantly (P < 0.05) higher in animals treated using eCG (1.0 ± 0.4mm/day) than in the control group (0.9 ± 0.4mm/day). The diameter of the preovulatory follicle was significantly higher (P < 0.05) in the animals treated with 300 IU (10.1 ± 1.4mm) than in untreated animals (9.3 ± 1.2mm). Follicle growth rate was significantly higher (P<0.05) inn the animals treated with 300 IU (10,1 ± 1,4 mm) than in the control group (0.9±0,4 mm/day). The average interval between the time of eCG injection and ovulation was similar in the non-treated (83.7 ± 14.4 h) and treated animals (79.7 ± 11.9). Treated animals sowed a significant increase in the percentga of ovulation (94,7 %) compared to 73,1 %) (P<0.01). Use of eCG combined contributed towards synchronising the time of ovulation between 72 to 96 hours, which would facilitate the use of systematic insemination. [less ▲]

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See detailInfluence of rhizobacterial volatiles on the root system architecture and the production and allocation of biomass in the model grass Brachypodium distachyon (L.) P. Beauv.
Delaplace, Pierre ULg; Delory, Benjamin ULg; Baudson, Caroline ULg et al

in BMC Plant Biology (2015), 15(195),

Background Plant growth-promoting rhizobacteria are increasingly being seen as a way of complementing conventional inputs in agricultural systems. The effects on their host plants are diverse and include ... [more ▼]

Background Plant growth-promoting rhizobacteria are increasingly being seen as a way of complementing conventional inputs in agricultural systems. The effects on their host plants are diverse and include volatile-mediated growth enhancement. This study sought to assess the effects of bacterial volatiles on the biomass production and root system architecture of the model grass Brachypodium distachyon (L.) Beauv. Results An in vitro experiment allowing plant-bacteria interaction throughout the gaseous phase without any physical contact was used to screen 19 bacterial strains for their growth-promotion ability over a 10-day co-cultivation period. Five groups of bacteria were defined and characterised based on their combined influence on biomass production and root system architecture. The observed effects ranged from unchanged to greatly increased biomass production coupled with increased root length and branching. Primary root length was increased only by the volatile compounds emitted by Enterobacter cloacae JM22 and Bacillus pumilus T4. Overall, the most significant results were obtained with Bacillus subtilis GB03, which induced an 81% increase in total biomass, as well as enhancing total root length, total secondary root length and total adventitious root length by 88.5, 201.5 and 474.5%, respectively. Conclusions This study is the first report on bacterial volatile-mediated growth promotion of a grass plant. Contrasting modulations of biomass production coupled with changes in root system architecture were observed. Most of the strains that increased total plant biomass also modulated adventitious root growth. Under our screening conditions, total biomass production was strongly correlated with the length and branching of the root system components, except for primary root length. An analysis of the emission kinetics of the bacterial volatile compounds is being undertaken and should lead to the identification of the compounds responsible for the observed growth-promotion effects. Within the context of the inherent characteristics of our in vitro system, this paper identifies the next critical experimental steps and discusses them from both a fundamental and an applied perspective. [less ▲]

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See detailCharacterizing activity sequences using Profile Hidden Markov Models
Liu, Feng; Janssens, Davy; Cui, JianXun et al

in Expert Systems with Applications (2015), 42(13), 57055722

In literature, activity sequences, generated from activity-travel diaries, have been analyzed and classified into clusters based on the composition and ordering of the activities using Sequence Alignment ... [more ▼]

In literature, activity sequences, generated from activity-travel diaries, have been analyzed and classified into clusters based on the composition and ordering of the activities using Sequence Alignment Methods (SAM). However, using these methods, only the frequent activities in each cluster are extracted and qualitatively described; the infrequent activities and their related travel episodes are disregarded. Thus, to quantify the occurrence probabilities of all the daily activities as well as their sequential orders, we develop a novel process to build multiple alignments of the sequences and subsequently derive profile Hidden Markov Models (pHMMs). This process consists of 4 major steps. First, activity sequences are clustered based on a pre-defined scheme. The frequent activities along with their sequential orders are then identified in each cluster, and they are subsequently used as a template to guide the construction of a multiple alignment of the cluster of sequences. Finally, a pHMM is employed to convert the multiple alignment into a position-specific scoring system, representing the probability of each frequent activity at each important position of the alignment as well as the probabilities of both insertion and deletion of infrequent activities. By applying the derived pHMMs to a set of activity-travel diaries collected in Belgium as well as a group of mobile phone call location data recorded in Switzerland, the potential and effectiveness of the models in capturing the sequential features of each cluster and distinguishing them from those of other clusters, are demonstrated. The proposed method can also be utilized to improve activity-based transportation model validation and travel survey designs. Furthermore, it offers a wide application in characterizing a group of any related sequences, particularly sequences varying in length and with a high frequency of short sequences that are typically present in human behavior. [less ▲]

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See detailVitamin D status after a high dose of cholecalciferol in healthy and burn subjects
ROUSSEAU, Anne-Françoise ULg; DAMAS, Pierre ULg; LEDOUX, Didier ULg et al

in Burns : Journal of the International Society for Burn Injuries (2015), 41(5), 1028-1034

Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a ... [more ▼]

Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a cholecalciferol (VD3) bolus on VD status in adult burn patients (Group B, GB) after admission, compared to healthy subjects (Group H, GH). Methods: Both groups received an oral dose of 100,000 IU VD3. Blood samples were collected before (D0) and 7 days (D7) after bolus to measure 250H-D, 1,25(OH)2-D, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). Albumin (ALB) and VD binding protein (DBP) were measured and used to calculate free 25OH-D level. Data were expressed as median (min–max) or proportions. Results: A total of 49 subjects were included: 29 in GH and 20 in GB. At D0, prevalence of VD deficiency was higher in GB: 25OH-D was 21.5 (10.1–46.3) ng/ml in GH vs 11 (1.8–31.4) ng/ml in GB. DBP and ALB were lower in GB. At D7, DBP was stable in both groups while ALB decreased in GB. 25OH-D increased by 66.6 (13.5–260.3)% in GH. In GB, changes in 25OH-D extended from 36.7% to 333.3% with a median increase of 33.1%. Similar changes were observed in each group for free 25OH-D. High FGF23 levels were observed in GB. Conclusions: This study highlighted the differences in VD status and in response to a high dose VD3 in burn patients when compared to healthy patients. Pitfalls in VD status assessment are numerous during acute burn care: 25OH-D measurement needs cautious interpretation and interest of free 25OH-D is still questionable. They should not prevent burn patients to receive VD supplements during acute care. Higher doses than general recommendations should probably be considered. [less ▲]

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See detailPharmacists' role in handling problems with prescriptions for atithrombotic medication in Belgian community pharmacies
Desmaele; De Wulf, I; Dupont, AG et al

in International Journal of Clinical Pharmacy [=IJCP] (2015), 37(4), 656-668

Background Community pharmacists have an important task in the follow-up of patients treated with antithrombotics. When delivering these medicines, pharmacists can encounter drug–related problems (DRPs ... [more ▼]

Background Community pharmacists have an important task in the follow-up of patients treated with antithrombotics. When delivering these medicines, pharmacists can encounter drug–related problems (DRPs) with substantial clinical and economic impact. Objective To investigate the amount and type of antithrombotic related DRPs as well as how community pharmacists handled these DRPs. Setting Belgian community pharmacies. Methods MSc pharmacy students of six Belgian universities collected data about all DRPs encountered by a pharmacist during ten half days of their pharmacy internship. Data were registered about DRPs detected at delivery and in an a posteriori setting, when consulting the medical history of the patient. Classification of the DRP, cause of the DRP, intervention and result of the intervention were registered. Main outcome measure Amount and type of antotrombitocs related DRPs occurring in community pharmacies, as well as how community pharmacists handled these DRPs. Results 3.1 % of the 15,952 registered DRPs concerned antithrombotics. 79.3 % of these DRPs were detected at delivery and 20.7 % were detected a posteriori. Most antithrombotic-related DRPs concerned problems with the choice of the drug (mainly because of drug–drug interactions) or concerned logistic problems. Almost 80 % of the antithrombotic-related DRPs were followed by an intervention of the pharmacist, mainly at the patient’s level, resulting in 90.1 % of these DRPs partially or totally solved. Conclusion Different DRPs with antithrombotic medication occurred in Belgian community pharmacies. About 20 % was detected in an a posteriori setting, showing the benefit of medication review. Many of the encountered DRPs were of technical nature (60.7 %). These DRPs were time-consuming for the pharmacist to resolve and should be prevented. Most of the DRPs could be solved, demonstrating the added value of the community pharmacist as first line healthcare provider. [less ▲]

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See detailUse of specklegrams background terms for speckle photography combined with phase-shifting electronic speckle pattern interferometry
Zemmamouche, Redouane; Vandenrijt, Jean-François ULg; Medjahed, Aïcha et al

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (2015), 54(8), 084110

Electronic speckle pattern interferometry (ESPI) is combined with digital speckle photography (DSP) to measure out-of-plane deformation in the presence of large in-plane translation or rotation. ESPI is ... [more ▼]

Electronic speckle pattern interferometry (ESPI) is combined with digital speckle photography (DSP) to measure out-of-plane deformation in the presence of large in-plane translation or rotation. ESPI is used to measure out-of-plane displacements smaller than the speckle diameter. In-plane displacements larger than the speckle size are obtained by DSP using artifacts images computed from the phase-stepped specklegrams. Previous works use the specklegram modulation for that purpose, but we show that this can lead to errors in the case of low modulation. In order to avoid this, a simple averaging of phase-stepped specklegrams allows obtaining the average irradiance, which contains information on the speckled object image. The latter can be used more efficiently than the modulation in DSP and is simpler to compute. We also perform a numerical simulation of specklegrams, which show that the use of background terms is much more stable against some error sources as compared to modulation. We show experimental evidence of this in various experiments combining out-of-plane ESPI measurements with in-plane translations or rotations obtained by our DSP method. The latter has been used efficiently to restore phase loss in out-of-plane ESPI measurements due to large in-plane displacements. [less ▲]

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See detailThe Brussels Court judgement in Commission v Elevators manufacturers, or the story of how the Commission lost an action for damages based on its own infringement decision.
Marcos Ramos, Jorge ULg; Muheme, Daniel ULg

in European Competition Law Review (2015), 36(9),

With the proceedings before the Brussels Court, the Commission emphasized its growing need to promote claims for damages for infringements of EU Competition law. Ahead of the implementation of the Damages ... [more ▼]

With the proceedings before the Brussels Court, the Commission emphasized its growing need to promote claims for damages for infringements of EU Competition law. Ahead of the implementation of the Damages Directive, and with its own infringement decision in hand, this claim seemed to be an easy exercise for the Commission to recoup the allegedly surplus paid for the maintenance contracts. [less ▲]

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See detailPerformance et expérience esthétique : le régime contemporain (Rancière)
Hagelstein, Maud ULg

in Revue Philosophique de Louvain (2015), 113(3), 479-495

The theory of regimes of identification of art set up by the philosopher J. Rancière describes the transition from the former system of Fine Arts to the aesthetic regime of art. According to this ... [more ▼]

The theory of regimes of identification of art set up by the philosopher J. Rancière describes the transition from the former system of Fine Arts to the aesthetic regime of art. According to this contemporary regime the characteristic of the various arts no longer depends essentially on their technical skill (poiesis), but on the sensible experience they favour independently of their specific ways of doing things. Artistic performance fits in perfectly into this aesthetic regime of art having regard to its ideological project: (1) it aims at the enlargement of sense experience (aesthetic experience) beyond the mere production of an object, thus destabilising the frontiers between the artistic and the non-artistic; (2) it seeks to restore the links between art and ordinary experience in order to favour living art. We shall show that the ideas developed by the Anglo-Saxon pragmatist philosophy J. Dewey strongly contributed to the definition of this radical artistic project (transl. J. Dudley). [less ▲]

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See detailAtypical plasma cells with coexpression of myeloid markers and bundles of Auer rod-like inclusions.
KEUTGENS, Aurore ULg; FOGUENNE, Jacques ULg; Gothot, André ULg et al

in International journal of laboratory hematology (2015), 37(4), 85-6

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See detailFish consumption patterns and hair mercury levels in children and their mothers in 17 EU countries
Castano, Argelia; Cutanda, Francisco; Esteban, Marta et al

in Environmental Research (2015), 141

The toxicity of methylmercury (MeHg) in humans is well established and the main source of exposure is via the consumption of large marine fish and mammals. Of particular concern are the potential ... [more ▼]

The toxicity of methylmercury (MeHg) in humans is well established and the main source of exposure is via the consumption of large marine fish and mammals. Of particular concern are the potential neurodevelopmental effects of early life exposure to low-​levels of MeHg. Therefore, it is important that pregnant women, children and women of childbearing age are, as far as possible, protected from MeHg exposure. Within the European project DEMOCOPHES, we have analyzed mercury (Hg) in hair in 1799 mother-​child pairs from 17 European countries using a strictly harmonized protocol for mercury anal. Parallel, harmonized questionnaires on dietary habits provided information on consumption patterns of fish and marine products. After hierarchical cluster anal. of consumption habits of the mother-​child pairs, the DEMOCOPHES cohort can be classified into two branches of approx. similar size: one with high fish consumption (H) and another with low consumption (L)​. All countries have representatives in both branches, but Belgium, Denmark, Spain, Portugal and Sweden have twice as many or more mother-​child pairs in H than in L. For Switzerland, Czech Republic, Hungary, Poland, Romania, Slovenia and Slovakia the situation is the opposite, with more representatives in L than H. There is a strong correlation (r=0.72) in hair mercury concn. between the mother and child in the same family, which indicates that they have a similar exposure situation. The clustering of mother-​child pairs on basis of their fish consumption revealed some interesting patterns. One is that for the same sea fish consumption, other food items of marine origin, like seafood products or shellfish contribute significantly to the mercury levels in hair. We conclude that addnl. studies are needed to assess and quantify exposure to mercury from seafood products, in particular. The cluster anal. also showed that 95​% of mothers who consume once per wk fish only, and no other marine products, have mercury levels 0.55 μg​/g. Thus, the 95th percentile of the distribution in this group is only around half the US-​EPA recommended threshold of 1 μg​/g mercury in hair. Consumption of freshwater fish played a minor role in contributing to mercury exposure in the studied cohort. The DEMOCOPHES data shows that there are significant differences in MeHg exposure across the EU and that exposure is highly correlated with consumption of fish and marine products. Fish and marine products are key components of a healthy human diet and are important both traditionally and culturally in many parts of Europe. Therefore, the communication of the potential risks of mercury exposure needs to be carefully balanced to take into account traditional and cultural values as well as the potential health benefits from fish consumption. European harmonized human biomonitoring programs provide an addnl. dimension to national HMB programs and can assist national authorities to tailor mitigation and adaptation strategies (dietary advice, risk communication, etc.) to their country's specific requirements. [less ▲]

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See detailDigestibility of solvent-treated Jatropha curcas kernel by broiler chickens in Senegal
Nesseim, Thierry Daniel Tamsir; Dieng, Abdoulaye; Mergeai, Guy ULg et al

in Tropical Animal Health and Production (2015)

Jatropha curcas is a drought-resistant shrub belonging to the Euphorbiaceae family. The kernel contains approximately 60 % lipid in dry matter, and the meal obtained after oil extraction could be an ... [more ▼]

Jatropha curcas is a drought-resistant shrub belonging to the Euphorbiaceae family. The kernel contains approximately 60 % lipid in dry matter, and the meal obtained after oil extraction could be an exceptional source of protein for family poultry farming, in the absence of curcin and, especially, some diterpene derivatives phorbol esters that are partially lipophilic. The nutrient digestibility of J. curcas kernel meal (JKM), obtained after partial physicochemical deoiling was thus evaluated in broiler chickens. Twenty broiler chickens, 6 weeks old, were maintained in individual metabolic cages and divided into four groups of five animals, according to a 4 × 4 Latin square design where deoiled JKM was incorporated into grinded corn at 0, 4, 8, and 12 % levels (diets 0, 4, 8, and 12 J), allowing measurement of nutrient digestibility by the differential method. The dry matter (DM) and organic matter (OM) digestibility of diets was affected to a low extent by JKM (85 and 86 % in 0 J and 81 % in 12 J, respectively) in such a way that DM and OM digestibility of JKM was estimated to be close to 50 %. The ether extract (EE) digestibility of JKM remained high, at about 90 %, while crude protein (CP) and crude fiber (CF) digestibility were largely impacted by JKM, with values closed to 40 % at the highest levels of incorporation. J. curcas kernel presents various nutrient digestibilities but has adverse effects on CP and CF digestibility of the diet. The effects of an additional heat or biological treatment on JKM remain to be assessed. [less ▲]

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See detailThe ecology of health care in a Belgian area
Vo, Than Liem; Duchesnes, Christiane ULg; Vögeli, Olivier et al

in Acta Clinica Belgica (2015), 70(4), 280-286

Abstract INTRODUCTION: Focusing on the monthly prevalence of health problems and recourse to different levels of care of the population is an interesting approach to demonstrate the respective roles of ... [more ▼]

Abstract INTRODUCTION: Focusing on the monthly prevalence of health problems and recourse to different levels of care of the population is an interesting approach to demonstrate the respective roles of different levels of health care. In the present study, the ecology of health care was studied in the region of Liège, Belgium. METHOD: A survey questioning people about their health problems was conducted in 2009 in two communes of the province of Liège. For each health problem, 'health care' was defined as contact with any qualified care provider. For each consultation, three elements were recorded: the profession of the health care provider; the place where the care was provided and the kind of health care received. RESULTS: A total of 537 people were interviewed. The monthly prevalence of people who experienced a health problem during the previous month was 85.1%. The monthly prevalence of people who turned to a health care provider at least once during the month was 62.2%. The proportion of people turning to doctors, primarily local doctors, for a simple consultation was important (49.2%). DISCUSSION: Our results are highly comparable with those of other studies. Recourse to a doctor is high (49%), which probably reflects the broad accessibility of health care in Belgium and maybe its overuse. Additional questions on the current and future organisation of the Belgian health care system are debated. [less ▲]

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See detailUse of Tomosynthesis for Detection of Bone Erosions of the Foot in Patients With Established Rheumatoid Arthritis: Comparison With Radiography and CT.
SIMONI, Paolo ULg; Gerard, Lionel ULg; KAISER, Marie-Joëlle ULg et al

in American Journal of Roentgenology (2015), (205), 364-370

The purpose of this study was to compare tomosynthesis with radiography for the detection of bone erosions of the foot in patients with established rheumatoid arthritis (RA) using MDCT as a reference ... [more ▼]

The purpose of this study was to compare tomosynthesis with radiography for the detection of bone erosions of the foot in patients with established rheumatoid arthritis (RA) using MDCT as a reference standard. [less ▲]

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See detailPerformance, robustness and sensitivity analysis of the nonlinear tuned vibration absorber
Detroux, Thibaut ULg; Habib, Giuseppe ULg; Masset, Luc ULg et al

in Mechanical Systems & Signal Processing (2015), 60-61

The nonlinear tuned vibration absorber (NLTVA) is a recently developed nonlinear absorber which generalizes Den Hartog׳s equal peak method to nonlinear systems. If the purposeful introduction of ... [more ▼]

The nonlinear tuned vibration absorber (NLTVA) is a recently developed nonlinear absorber which generalizes Den Hartog׳s equal peak method to nonlinear systems. If the purposeful introduction of nonlinearity can enhance system performance, it can also give rise to adverse dynamical phenomena, including detached resonance curves and quasiperiodic regimes of motion. Through the combination of numerical continuation of periodic solutions, bifurcation detection and tracking, and global analysis, the present study identifies boundaries in the NLTVA parameter space delimiting safe, unsafe and unacceptable operations. The sensitivity of these boundaries to uncertainty in the NLTVA parameters is also investigated. [less ▲]

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See detailA study of composite laminates failure using an anisotropic gradient-enhanced damage mean-field homogenization model
Wu, Ling ULg; Sket, Federico; Molina-Aldareguia, Jon M et al

in Composite Structures (2015), 126

The failure of carbon fiber reinforced epoxy laminates is studied using an anisotropic gradient-enhanced continuum damage model embedded in a mean-field homogenization scheme. In each ply, a homogenized ... [more ▼]

The failure of carbon fiber reinforced epoxy laminates is studied using an anisotropic gradient-enhanced continuum damage model embedded in a mean-field homogenization scheme. In each ply, a homogenized material law is used to capture the intra-laminar failure. The anisotropy of the homogenized material model results from the homogenization method and from the reformulation of the non-local continuum damage theory to account for the material anisotropy. As a result the damage propagation direction in each ply is predicted with accuracy as compared to the experimental results, while the problems of losing uniqueness and strain localization, which occur in classical finite element simulations when strain softening of materials is involved, can be avoided. To model the delamination process, the hybrid discontinuous Galerkin/extrinsic cohesive law method is introduced at the ply interfaces. This hybrid method avoids the need to propagate topological changes in the mesh with the propagation of the delamination while it preserves the consistency and stability in the un-cracked interfaces. As a demonstration, open-hole coupons with different stacking sequences are studied numerically and experimentally. Both the intra- and inter-laminar failure patterns are shown to be well captured by the computational framework. [less ▲]

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See detailL’action du FDF dans les Régions et Communautés (1971-2014). II. Institutions bruxelloises
Lanneau, Catherine ULg

in Courrier Hebdomadaire du CRISP (2015), (2260-2261), 61

Depuis sa création, le FDF poursuit un triple objectif au plan institutionnel : assurer la solidarité entre Wallons et Bruxellois francophones, garantir les droits linguistiques des francophones de ... [more ▼]

Depuis sa création, le FDF poursuit un triple objectif au plan institutionnel : assurer la solidarité entre Wallons et Bruxellois francophones, garantir les droits linguistiques des francophones de Flandre (en particulier dans la périphérie) et bâtir une Région bruxelloise forte (avec si possible un territoire élargi). Pour promouvoir ses idées, le FDF a porté son combat non seulement sur le terrain communal et national, mais également dans les Régions et les Communautés. Le présent Courrier hebdomadaire retrace les principales lignes de force de l’action du FDF dans les organes des entités fédérées où il a été présent au cours des cinquante dernières années : le Parlement de la Communauté française, le Parlement flamand et les institutions bruxelloises. Quel rôle le FDF a-t-il joué à la Communauté française ? Quelle a été l’action de son député au Parlement flamand ? Comment s’est articulée la lutte du parti pour l’institutionnalisation d’une Région bruxelloise et, une fois celle-ci créée en 1989, dans quelle mesure y a-t-il appliqué son programme ? Le FDF a-t-il réussi à dépasser son image de parti focalisé sur les thématiques linguistiques pour se positionner en mouvement « urbain et culturel » se définissant comme « réformateur social » ? L’attention se porte sur la pratique du parti tant agissant seul qu’évoluant en partenariat avec le Rassemblement wallon ou, plus récemment, avec les libéraux. [less ▲]

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See detailL’action du FDF dans les Régions et Communautés (1971-2014). I. Le Parlement de la Communauté française et le Parlement flamand
Lanneau, Catherine ULg

in Courrier Hebdomadaire du CRISP (2015), (2258-2259), 60

Depuis sa création, le FDF poursuit un triple objectif au plan institutionnel : assurer la solidarité entre Wallons et Bruxellois francophones, garantir les droits linguistiques des francophones de ... [more ▼]

Depuis sa création, le FDF poursuit un triple objectif au plan institutionnel : assurer la solidarité entre Wallons et Bruxellois francophones, garantir les droits linguistiques des francophones de Flandre (en particulier dans la périphérie) et bâtir une Région bruxelloise forte (avec si possible un territoire élargi). Pour promouvoir ses idées, le FDF a porté son combat non seulement sur le terrain communal et national, mais également dans les Régions et les Communautés. Le présent Courrier hebdomadaire retrace les principales lignes de force de l’action du FDF dans les organes des entités fédérées où il a été présent au cours des cinquante dernières années : le Parlement de la Communauté française, le Parlement flamand et les institutions bruxelloises. Quel rôle le FDF a-t-il joué à la Communauté française ? Quelle a été l’action de son député au Parlement flamand ? Comment s’est articulée la lutte du parti pour l’institutionnalisation d’une Région bruxelloise et, une fois celle-ci créée en 1989, dans quelle mesure y a-t-il appliqué son programme ? Le FDF a-t-il réussi à dépasser son image de parti focalisé sur les thématiques linguistiques pour se positionner en mouvement « urbain et culturel » se définissant comme « réformateur social » ? L’attention se porte sur la pratique du parti tant agissant seul qu’évoluant en partenariat avec le Rassemblement wallon ou, plus récemment, avec les libéraux. [less ▲]

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See detailRupture post-traumatique de l’isthme aortique : perspectives modernes de prise en charge
BRULS, Samuel ULg; GOFFIN, Pierre ULg; Sakalihasan, Natzi ULg et al

in Revue Médicale de Liège (2015), 70(9), 415-22

Traumatic aortic rupture of the thoracic aorta (usually at the isthmus) is frequently associated with concomitant life-threatening injuries. Historically, the conventional care consisted of surgical ... [more ▼]

Traumatic aortic rupture of the thoracic aorta (usually at the isthmus) is frequently associated with concomitant life-threatening injuries. Historically, the conventional care consisted of surgical repair of the lesion performed as soon as possible. However, in spite of constant technical improvements the morbi-mortality remains high because of these associated lesions. In addition, their management can have priority and delay aortic surgery. The endovascular approach has been shown to be a feasible and efficient technique and currently represents a valuable alternative to open surgery for patients with multiple traumas. We report a patient presenting with a traumatic aortic rupture of the aortic isthmus, which was successfully treated by delayed combined endovascular (thoracic aortic stentgrafting) and open approach (hemi-aortic arch debranching). [less ▲]

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See detailOpérations militaires : entre prise de risque, solidarité, souveraineté et "entrée en premier"
Dumoulin, André ULg

in Sécurité & Stratégie (2015), (201),

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See detailLe Parc National Sahamalaza - Iles Radama serait-il l’ultime refuge pour certaines espèces de lémuriens du nord-ouest de Madagascar ?
Wilmet, Leslie ULg; Beudels-Jamar, Roseline C.; Schwitzer, Christoph et al

in Tropicultura (2015)

Depuis des millions d’années, la faune et la flore terrestre de Madagascar ont évolué dans un espace isolé. Suite à cette situation, le niveau d’endémisme y est très élevé et l’ensemble de l’île ... [more ▼]

Depuis des millions d’années, la faune et la flore terrestre de Madagascar ont évolué dans un espace isolé. Suite à cette situation, le niveau d’endémisme y est très élevé et l’ensemble de l’île représente un des plus importants hotspot de biodiversité. Madagascar fait aussi partie des pays les plus touchés en termes de destruction des habitats naturels ; 90 % de la végétation d’origine est aujourd’hui perdue. La déforestation et la fragmentation des habitats forestiers menace particulièrement les primates de l’île, les lémuriens. L’île est considérée par de nombreuses organisations internationales comme une priorité pour la conservation de la nature, autant dans le domaine zoologique que botanique. Les premières aires protégées de Madagascar ont été établies en 1927 et l’île en compte aujourd’hui 47. Cet article reprend l’historique et fait l’état des lieux du parc national Sahamalaza-Ile Radama, situé au nord-ouest de Madagascar. Nous nous intéressons spécifiquement à deux espèces de lémuriens emblématiques du parc ; Eulemur flavifrons et Lepilemur sahamalazensis ainsi qu’aux menaces qui pèsent sur leur écosystème. Différentes mesures ont été proposées dans le cadre d’un Plan d’Action de Conservation afin d’en améliorer la gestion et assurer la survie de ces espèces. [less ▲]

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See detailp-regularity of the p-adic valuation of the Fibonacci sequence
Medina, Luis; Rowland, Eric ULg

in Fibonacci Quarterly (The) (2015), 53(3), 265-271

We show that the p-adic valuation of the sequence of Fibonacci numbers is a p-regular sequence for every prime p. For p≠2,5, we determine that the rank of this sequence is α(p)+1, where α(m) is the ... [more ▼]

We show that the p-adic valuation of the sequence of Fibonacci numbers is a p-regular sequence for every prime p. For p≠2,5, we determine that the rank of this sequence is α(p)+1, where α(m) is the restricted period length of the Fibonacci sequence modulo m. [less ▲]

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See detailDesign, Modeling, and Performance Optimization of a Reversible Heat Pump/Organic Rankine Cycle System for Domestic Application
Quoilin, Sylvain ULg; Dumont, Olivier ULg; Harley Hansen, Kristian et al

in Journal of Engineering for Gas Turbines and Power (2015)

In this paper, an innovative system combining a heat pump (HP) and an organic Rankine cycle (ORC) process is proposed. This system is integrated with a solar roof, which is used as a thermal source to ... [more ▼]

In this paper, an innovative system combining a heat pump (HP) and an organic Rankine cycle (ORC) process is proposed. This system is integrated with a solar roof, which is used as a thermal source to provide heat in winter months (HP mode) and electricity in summer months (ORC mode) when an excess irradiation is available on the solar roof. The main advantage of the proposed unit is its similarity with a traditional HP: the HP/ORC unit only requires the addition of a pump and four-way valves compared to a simple HP, which can be achieved at a low cost. A methodology for the optimal sizing and design of the system is proposed, based on the optimization of both continuous parameters such as heat exchanger size or discrete variables such as working fluid. The methodology is based on yearly simulations, aimed at optimizing the system performance (the net yearly power generation) over its whole operating range instead of just nominal sizing operating conditions. The simulations allow evaluating the amount of thermal energy and electricity generated throughout the year, yielding a net electric power output of 3496 kWh throughout the year. [less ▲]

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See detailShort-term responses of glass eels transported from UK to small Belgian streams
Ovidio, Michaël ULg; Tarrago-Bes, Frédérique; Nzau Matondo, Billy ULg

in Annales de Limnologie = International Journal of Limnology (2015), 51(3), 219-226

Restocking of inland waters with glass eels is one of the recovery options to prevent the decline of European eel Anguilla anguilla (L.) populations. We studied the growth, dispersion, density and habitat ... [more ▼]

Restocking of inland waters with glass eels is one of the recovery options to prevent the decline of European eel Anguilla anguilla (L.) populations. We studied the growth, dispersion, density and habitat preferences in the imported glass eels from United-Kingdom and stocked in three typologically different small Belgian streams, using electrofishing surveys around the single release point, 1 year following stocking. Our results clearly support that the recaptured individuals stocked in our streams farther from the sea, survived, grew, dispersed upstream and downstream. Elvers exploited the complete transversal section of stream, with preference for the sheltered microhabitats near the banks with slower water velocity and low depth. Length-weight relationship was different between streams in terms of allometric coefficient (b). We assume that microhabitats and food availabilities lead to contrasted results in terms of growth and absolute occurrence. Restocking of glass eels in small middle-land streams was found to be an interesting and unconventional option that requires adequate stream and habitat selection. [less ▲]

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See detailElectrical characterization of p-GeSn/n-Ge diodes with interface traps under dc and ac regimes
Baert, Bruno ULg; Gupta, Somya; Gencarelli, Federica et al

in Solid-State Electronics (2015), 110

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See detailChallenges for Scale-Up of Batch Separations
Pfennig, Andreas ULg; Becker, Karsten; Bach, S. et al

in Chemie Ingenieur Technik (2015), 87(8), 1051

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See detailA simple approach for ultrasensitive detection of bisphenols by multiplexed surface-enhanced Raman scattering
De Bleye, Charlotte ULg; Dumont, Elodie ULg; Hubert, Cédric ULg et al

in Analytica Chimica Acta (2015), 888

Bisphenol A (BPA) is well known for its use in plastic manufacture and thermal paper production despite its risk of health toxicity as an endocrine disruptor in humans. Since the publication of new ... [more ▼]

Bisphenol A (BPA) is well known for its use in plastic manufacture and thermal paper production despite its risk of health toxicity as an endocrine disruptor in humans. Since the publication of new legislation regarding the use of BPA, manufacturers have begun to replace BPA with other phenolic molecules such as bisphenol F (BPF) and bisphenol B (BPB), but there are no guarantees regarding the health safety of these compounds at this time. In this context, a very simple, cheap and fast surface-enhanced Raman scattering (SERS) method was developed for the sensitive detection of these molecules in spiked tap water solutions. Silver nanoparticles were used as SERS substrates. An original strategy was employed to circumvent the issue of the affinity of bisphenols for metallic surfaces and the silver nanoparticles surface was functionalized using pyridine in order to improve again the sensitivity of the detection. Semi-quantitative detections were performed in tap water solutions at a concentrations range from 0.25 to 20 µg L-1 for BPA and BPB and from 5 to 100 µg L-1 for BPF. Moreover, a feasibility study for performing a multiplex-SERS detection of these molecules was also performed before successfully implementing the developed SERS method on real samples. [less ▲]

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See detailOptimization of composite structures with curved fiber trajectories
Lemaire, Etienne; Zein, Samih; Bruyneel, Michaël ULg

in Composite Structures (2015), 131

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See detailQuand le progrès doit rester humain
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2015), 58

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See detailChemical spying in coral reef fish larvae at recruitment
Roux, Natacha; Brooker, Rohan M.; Lecellier, Gaël et al

in Comptes Rendus Biologies (2015), 338

When fish larvae recruit back to a reef, chemical cues are often used to find suitable habitat or to find juvenile or adult conspecifics. We tested if the chemical information used by larvae was ... [more ▼]

When fish larvae recruit back to a reef, chemical cues are often used to find suitable habitat or to find juvenile or adult conspecifics. We tested if the chemical information used by larvae was intentionally produced by juvenile and adult conspecifics already on the reef (communication process) or whether the cues used result from normal biochemical processes with no active involvement by conspecifics (‘‘spying’’ behavior by larvae). Conspecific chemical cues attracted the majority of larvae (four out of the seven species tested); although while some species were equally attracted to cues from adults and juveniles (Chromis viridis, Apogon novemfasciatus), two exhibited greater sensitivity to adult cues (Pomacentrus pavo, Dascyllus aruanus). Our results indicate also that spying cues are those most commonly used by settling fishes (C. viridis, P. pavo, A. novemfasciatus). Only one species (D. aruanus) preferred the odour of conspecifics that had had visual contact with larvae (communication). [less ▲]

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See detailLe monopole de la légitimité démocratique
Debras, François ULg

in Revue de la Faculté de Droit de l'Université de Liège (2015), 2

Loin d’être le résultat de facteurs externes, la contestation du régime démocratique semble être avant tout le résultat d’une critique inhérente au système. Différents indicateurs mesurables viennent ... [more ▼]

Loin d’être le résultat de facteurs externes, la contestation du régime démocratique semble être avant tout le résultat d’une critique inhérente au système. Différents indicateurs mesurables viennent étayer ce que certains auteurs qualifient de « syndrome de fatigue démocratique » ou encore de « corruption du régime constitutionnel pluraliste », tels que l’augmentation de l’abstentionnisme durant les périodes électorales, une volatilité et une instabilité croissante de l’électorat et une baisse des adhésions aux organisations collectives. Fait tout aussi significatif, il semblerait que les jeunes démocraties dans les pays de l’ex-Union soviétique, d’Asie ou d’Amérique latine n’échappent pas non plus à ces phénomènes. Cette situation illustre-t-elle une perte de légitimité démocratique, une crise démocratique ou ne correspond-elle pas plutôt à une volonté citoyenne de transformer nos démocraties en élargissant et en approfondissant certaines de ses dynamiques et procédures qui lui sont propres ? Pour répondre à cette question, nous proposons de nous concentrer sur trois éléments distincts, mais étroitement liés au sein de nos démocraties européennes au XXIe siècle : le lien représentant/représenté (la représentation), la reconnaissance des libertés individuelles vis-à-vis de l’organisation collective de la société (les citoyens) et l’action du pouvoir étatique (l’État). [less ▲]

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See detailSystematic analysis of site-specific yield distributions resulting from nitrogen management and climatic variability interactions
Dumont, Benjamin ULg; Basso, Bruno; Leemans, Vincent ULg et al

in Precision Agriculture (2015), 16(4), 361-384

At the plot level, crop simulation models such as STICS have the potential to evaluate risk associated with management practices. In nitrogen (N) management, however, the decision-making process is ... [more ▼]

At the plot level, crop simulation models such as STICS have the potential to evaluate risk associated with management practices. In nitrogen (N) management, however, the decision-making process is complex because the decision has to be taken without any knowledge of future weather conditions. The objective of this paper is to present a general methodology for assessing yield variability linked to climatic uncertainty and variable N rate strategies. The STICS model was coupled with the LARS-Weather Generator. The Pearson system and coefficients were used to characterise the shape of yield distribution. Alternatives to classical statistical tests were proposed for assessing the normality of distributions and conducting comparisons (namely, the Jarque-Bera and Wilcoxon tests, respectively). Finally, the focus was put on the probability risk assessment, which remains a key point within the decision process. The simulation results showed that, based on current N application practice among Belgian farmers (60 60 60 kgN ha-1), yield distribution was very highly significantly non normal, with the highest degree of asymmetry characterised by a skewness value of -1.02. They showed that this strategy gave the greatest probability (60%) of achieving yields that were superior to the mean (10.5 t ha-1) of the distribution. [less ▲]

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See detailA Simple Laparoscopic Procedure to Restore a Normal Vaginal Length After Colpohysterectomy With Large Upper Colpectomy for Cervical and/or Vaginal Neoplasia.
Leblanc, Eric; Bresson, L.; Merlot, B. et al

in Journal of Minimally Invasive Gynecology (2015)

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See detailPredictions of Daily Milk and Fat Yields, Major Groups of Fatty Acids, and C18:1 cis-9 from Single Milking Data without a Milking Interval
Arnould, Valérie ULg; Reding, Romain; Bormann, Jeanne et al

in Animals (2015), 5(3), 643-661

Reducing the frequency of milk recording would help reduce the costs of official milk recording. However, this approach could also negatively affect the accuracy of predicting daily yields. This problem ... [more ▼]

Reducing the frequency of milk recording would help reduce the costs of official milk recording. However, this approach could also negatively affect the accuracy of predicting daily yields. This problem has been investigated in numerous studies. In addition, published equations take into account milking intervals (MI), and these are often not available and/or are unreliable in practice. The first objective of this study was to propose models in which the MI was replaced by a combination of data easily recorded by dairy farmers. The second objective was to further investigate the fatty acids (FA) present in milk. Equations to predict daily yield from AM or PM data were based on a calibration database containing 79,971 records related to 51 traits [milk yield (expected AM, expected PM, and expected daily); fat content (expected AM, expected PM, and expected daily); fat yield (expected AM, expected PM, and expected daily; g/day); levels of seven different FAs or FA groups (expected AM, expected PM, and expected daily; g/dL milk), and the corresponding FA yields for these seven FA types/groups (expected AM, expected PM, and expected daily; g/day)]. These equations were validated using two distinct external datasets. The results obtained from the proposed models were compared to previously published results for models which included a MI effect. The corresponding correlation values ranged from 96.4% to 97.6% when the daily yields were estimated from the AM milkings and ranged from 96.9% to 98.3% when the daily yields were estimated from the PM milkings. The simplicity of these proposed models should facilitate their use by breeding and milk recording organizations. [less ▲]

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See detailWhen it is not inflammatory bowel disease: differential diagnosis
Louis, Edouard ULg

in Current Opinion in Gastroenterology (2015)

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See detailSpeed limit to the Abrikosov lattice in mesoscopic superconductors
Grimaldi, Gaia; Leo, Antonio; Sabatino, P. et al

in Physical Review. B : Condensed Matter (2015), 92

We study the instability of the superconducting state in a mesoscopic geometry for the low pinning material Mo3Ge characterized by a large Ginzburg-Landau parameter. We observe that in the current driven ... [more ▼]

We study the instability of the superconducting state in a mesoscopic geometry for the low pinning material Mo3Ge characterized by a large Ginzburg-Landau parameter. We observe that in the current driven switching to the normal state from a nonlinear region of the Abrikosov flux flow, the mean critical vortex velocity reaches a limiting maximum velocity as a function of the applied magnetic fi eld. Based on time dependent Ginzburg-Landau simulations we argue that the observed behavior is owed to the high velocity vortex dynamics confi ned on a mesoscopic scale. We build up a general phase diagram which includes all possible dynamic confi gurations of Abrikosov lattice in a mesoscopic superconductor. [less ▲]

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See detailComparison between observed and simulated aeolian snow mass fluxes in Adélie Land, East Antarctica
Amory, Charles; Trouvillez, A.; Gallée, H. et al

in Cryosphere (The) (2015), 9

The regional climate model MAR including a coupled snow pack/aeolian snow transport parameterisation is compared with aeolian snow mass fluxes at a fine spatial resolution (5 km horizontally and 2 m ... [more ▼]

The regional climate model MAR including a coupled snow pack/aeolian snow transport parameterisation is compared with aeolian snow mass fluxes at a fine spatial resolution (5 km horizontally and 2 m vertically) and at a fine temporal resolution (30 min) over 1 month in Antarctica. Numerous feedbacks are taken into account in the MAR including the drag partitioning caused by the roughness elements. Wind speed is correctly simulated with a positive value of the Nash test (0.60 and 0.37) but the wind speeds above 10 m s−1 are underestimated. The aeolian snow transport events are correctly reproduced with a good temporal resolution except for the aeolian snow transport events with a particles' maximum height below 1 m. The simulated threshold friction velocity, calculated without snowfall, is overestimated. The simulated aeolian snow mass fluxes between 0 to 2 m have the same variations but are underestimated compared to the second-generation FlowCapt values and so is the simulated relative humidity at 2 m. This underestimation is not entirely due to the underestimation of the simulated wind speed. The MAR underestimates the aeolian snow quantity that pass through the first two meters by a factor ten compared to the second-generation FlowCapt value (13 990 kg m−1 and 151 509 kg m−1 respectively). It will conduct the MAR, with this parametrisation, to underestimate the effect of the aeolian snow transport on the Antarctic surface mass balance. [less ▲]

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See detailMonitoring surface water content using visible and short-wave infrared SPOT-5 data of wheat plots in irrigated semi-arid regions
Benabdelouahab, Tarik ULg; Balaghi, Riad; Hadria, Rachid et al

in International Journal of Remote Sensing (2015), 36(15), 4018-4036

Irrigated agriculture is an important strategic sector in arid and semi-arid regions. Given the large spatial coverage of irrigated areas, operational tools based on satellite remote sensing can ... [more ▼]

Irrigated agriculture is an important strategic sector in arid and semi-arid regions. Given the large spatial coverage of irrigated areas, operational tools based on satellite remote sensing can contribute to their optimal management. The aim of this study was to evaluate the potential of two spectral indices, calculated from SPOT-5 high-resolution visible (HRV) data, to retrieve the surface water content values (from bare soil to completely covered soil) over wheat fields and detect irrigation supplies in an irrigated area. These indices are the normalized difference water index (NDWI) and the moisture stress index (MSI), covering the main growth stages of wheat. These indices were compared to corresponding in situ measurements of soil moisture and vegetation water content in 30 wheat fields in an irrigated area of Morocco, during the 2012–2013 and 2013–2014 cropping seasons. NDWI and MSI were highly correlated with in situ measurements at both the beginning of the growing season (sowing) and at full vegetation cover (grain filling). From sowing to grain filling, the best correlation (R2 = 0.86; p < 0.01) was found for the relationship between NDWI values and observed soil moisture values. These results were validated using a k-fold cross-validation methodology; they indicated that NDWI can be used to estimate and map surface water content changes at the main crop growth stages (from sowing to grain filling). NDWI is an operative index for monitoring irrigation, such as detecting irrigation supplies and mitigating wheat water stress at field and regional levels in semi-arid areas. [less ▲]

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See detailDetermination of blood concentration levels of psychotrope medications in Rwandan patients
Hahirwa, Innocent; DENOOZ, Raphael ULg; Karangwa, Charles et al

in Acta Clinica Belgica (2015)

OBJECTIVES: In Rwanda, no therapeutic monitoring of psychotropic drugs is done. This results in difficult treatment optimisation and exposition to a high risk of toxicity and drug ineffectiveness for ... [more ▼]

OBJECTIVES: In Rwanda, no therapeutic monitoring of psychotropic drugs is done. This results in difficult treatment optimisation and exposition to a high risk of toxicity and drug ineffectiveness for patients under treatment. This study aimed to determine blood concentration levels of psychotropic drugs in Rwandan patients and identify problems associated with the lack of therapeutic drug monitoring (TDM) of these drugs. METHODS: The analysis was performed on 1 ml of serum sample using prazepam as internal standard. Regarding the step of sample preparation, we used a liquid-liquid extraction with a mixture of organic solvents: diethyl ether/dichloromethane/hexane/n-amyl alcohol (50/30/20/0.5:V/V). A Waters Alliance 2695 was used for analysis. The chromatography was run on a Symmetry C8 column and as mobile phase acetonitrile and phosphate buffer (pH 3.8) were used. RESULTS: Concerning the results, serum samples from 128 patients were analysed. Twenty-one different psychotropic drugs belonging to various pharmacological classes were detected and quantified. Analytical results were put into three categories based upon therapeutic reference ranges (TRR) of various drugs: subtherapeutic, therapeutic and supratherapeutic. For a total of 237 analyses, results within TRR represented 46% while 47 and 8% of results were, respectively, below and above TRR. CONCLUSION: It was therefore concluded that patients under psychotropic treatment in Rwanda are exposed to both the risk of drug ineffectiveness and the risk of toxicity (54%) with only 46% of results within the TRR. Consequently, TDM is needed to optimise psychotropic treatment in Rwandan patients. [less ▲]

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See detailSpatio‑temporal dynamics of β‑tubulin isotypes during the development of the sensory auditory organ in rat
Renauld, Justine ULg; Johnen, Nicolas; Thelen, Nicolas ULg et al

in Histochemistry & Cell Biology (2015)

There are different β-tubulin isoforms in microtubules of vertebrate tissues. However, their functional significance is still largely unknown. In the present study, we investigated the localization of ... [more ▼]

There are different β-tubulin isoforms in microtubules of vertebrate tissues. However, their functional significance is still largely unknown. In the present study, we investigated the localization of five β-tubulin isotypes (β1– 5) within the hearing organ during development in rat. By using confocal microscopy, we showed that with the exception of the β3-tubulin isoform that was specific to nerve fibres, all the different β-tubulin isoforms were mainly present in the supporting cells. Contrary to β1–4-tubulins, we also found that the β5-tubulin isoform appeared only at a key stage of the post-natal development in specific cell types (pillar cells and Deiters’ cells). By using transmission electron microscopy, we revealed further that this developmental stage coincided with the formation of two separate bundles of microtubules from a unique one in these supporting cells. Together, these results suggest that the β5-tubulin isoform might be involved in the generation of new microtubule bundles from a pre-existing one. [less ▲]

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See detailStatistical treatment of 2D NMR COSY spectra in metabolomics: data preparation, clustering-based evaluation of the Metabolomic Informative Content and comparison with 1H-NMR
Feraud, Baptiste; Govaerts, Bernadette; Verleysen, Michel et al

in Metabolomics : Official journal of the Metabolomic Society (2015), 11(6), 1756-1768

Compared with the widely used 1H-NMR spectroscopy, two-dimensional NMR experiments provide more sophisticated spectra which should facilitate the identification of relevant spectral zones or biomarkers in ... [more ▼]

Compared with the widely used 1H-NMR spectroscopy, two-dimensional NMR experiments provide more sophisticated spectra which should facilitate the identification of relevant spectral zones or biomarkers in metabolomics. This paper focuses on 1H-1H COrrelation SpectroscopY (COSY) spectral data. In spite of longer inherent acquisition times, it is commonly accepted by users (biologists, healthcare professionals) that the introduction of an additional dimension probably represents a huge qualitative step for investigations in terms of metabolites identification. Moreover, it seems natural that more information leads to more predictive power. But, until now, very few statistical studies clearly proved this assumption. Therefore a fundamental question is “Is this supplementary information relevant?”. In order to extend the statistical properties developed for 1D spectroscopy to the challenges raised by 2D spectra, a rigorous study of the performances of COSY spectra is needed as a prerequisite. Having introduced new pre-processing concepts, such as the Global Peak List or an ad hoc 2D “bucketing”, this paper presents an innovative methodology based on multivariate clustering algorithms to evaluate this question. Numerical clustering quality indexes and graphical results are proposed, based both on the spectral presence or absence of peaks (binary position vectors) and on peak intensities, and through different levels of spectral resolution. The second goal of this paper is to compare clustering performances obtained on COSY and on 1H-NMR spectra, with the aim of understanding to what extent the COSY spectra carry more Metabolomic Informative Content about the signal than 1D ones. The methodology is applied to two real experimental designs involving different groups of spectra (which define the signal): a 4-mixture cell culture media containing various supervised metabolites and a complex human serum based design. It is shown that COSY spectra appear to be statistically powerful and, in addition, provide better clustering results than corresponding 1H-NMR when using unlabeled information. Consequently, additional information appears to be relevant for metabolomics applications [less ▲]

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See detailAn EG-VEGF-dependent decrease in homeobox gene NKX3.1 contributes to cytotrophoblast dysfunction: a possible mechanism in human fetal growth restriction
Murthi, P; Brouillet, S; Pratt, A et al

in Molecular Medicine (2015)

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See detailGlobally significant greenhouse-gas emissions from African inland waters
Borges, Alberto ULg; Darchambeau, François ULg; Teodoru, Cristian R. et al

in Nature Geoscience (2015), advance online publication

Carbon dioxide emissions to the atmosphere from inland waters[mdash]streams, rivers, lakes and reservoirs[mdash]are nearly equivalent to ocean and land sinks globally. Inland waters can be an important ... [more ▼]

Carbon dioxide emissions to the atmosphere from inland waters[mdash]streams, rivers, lakes and reservoirs[mdash]are nearly equivalent to ocean and land sinks globally. Inland waters can be an important source of methane and nitrous oxide emissions as well, but emissions are poorly quantified, especially in Africa. Here we report dissolved carbon dioxide, methane and nitrous oxide concentrations from 12 rivers in sub-Saharan Africa, including seasonally resolved sampling at 39 sites, acquired between 2006 and 2014. Fluxes were calculated from published gas transfer velocities, and upscaled to the area of all sub-Saharan African rivers using available spatial data sets. Carbon dioxide-equivalent emissions from river channels alone were about 0.4 Pg carbon per year, equivalent to two-thirds of the overall net carbon land sink previously reported for Africa. Including emissions from wetlands of the Congo river increases the total carbon dioxide-equivalent greenhouse-gas emissions to about 0.9 Pg carbon per year, equivalent to about one quarter of the global ocean and terrestrial combined carbon sink. Riverine carbon dioxide and methane emissions increase with wetland extent and upland biomass. We therefore suggest that future changes in wetland and upland cover could strongly affect greenhouse-gas emissions from African inland waters. [less ▲]

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See detailAn echographic study of follicular growth during induced estrus in female Azawak zebu in Niger
Moussa Garba, Mahamadou; Moumouni, Issa; Hamani, Marichatou et al

in Tropical Animal Health and Production (2015), 47

An echographic study of follicular growth up to ovulation was carried out on 42 lactating Azawakh cows (Bos indicus) after estrus induction by means of a PGF2α or a procedure involving the administration ... [more ▼]

An echographic study of follicular growth up to ovulation was carried out on 42 lactating Azawakh cows (Bos indicus) after estrus induction by means of a PGF2α or a procedure involving the administration of progesterone vaginally (PRID® DELTA: Progesterone-releasing intravaginal device) for a ten-day period and the injection of a PGF2α and an eCG (400 and 800 IU) on withdrawal. All the animals treated in this way were inseminated 12 and 24 hrs after the onset of estrus. The percentage of estrus induced was not significantly different between the two groups of animals (81%). The average time delay before the onset of estrus was significantly longer after injection of a PGF2α (84.8 ± 26.0 hrs) than after withdrawal of the PRID® (59.2 ± 5.8 hrs). The average duration of the estrus was significantly shorter after its induction by PGF2α (12.6 ± 2.6 hrs) than after induction by progesterone (22.9 ± 2.7 hrs). There was not a significant difference in the interval between the beginning of estrus and ovulation in animals treated by PGF2α (30.3 hrs) and progesterone (28.4 hrs). Injection of a PGF2α was accompanied by a significantly lower rate of gestation than that obtained after treatment of animals by progesterone (31.2% vs 54.5 %). These results confirm the necessity to adapt an insemination policy to hormonal treatment for estrus induction in Bos indicus. [less ▲]

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See detailImmune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation following Flu-TBI versus TLI-ATG Conditioning
HANNON, Muriel ULg; BEGUIN, Yves ULg; Ehx, Grégory ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2015), 21(14), 3131-9

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft ... [more ▼]

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft-versus-tumor effects without graft-versus-host disease (GVHD). Experimental Design: We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n=28) or 8 Gy TLI plus anti-thymocyte globulin (TLI arm, n=25). Results: In comparison to TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P=0.02), a higher incidence of CMV reactivation (P<0.001), and a higher incidence of relapse (P=0.01). While recovery of total CD8+ T cells was similar in the two groups, with median CD8+ T cell counts reaching the normal values 40-60 days after allo-HCT, TLI patients had lower percentages of naïve CD8 T cells. Median CD4+ T cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Further, CD4+ T cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, while median absolute regulatory T cell (Treg) counts were comparable in TBI and TLI patients, Treg/naïve CD4+ T cell ratios were significantly higher in TLI than in TBI patients the 2 first years after transplantation. Conclusions: Immune recovery differs substantially between these two conditioning regimens possibly explaining the different clinical outcomes observed (NCT00603954). [less ▲]

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See detailA Modular Approach To Study Protein Adsorption on Surface Modified Hydroxyapatite
Ozhukil Kollath, Vinayaraj ULg; Van den Broeck, Freya; Fehér, Krisztina et al

in Chemistry : A European Journal (2015), 21(29), 10497-10505

Biocompatible inorganic nano- and microcarriers can be suitable candidates for protein delivery. This study demonstrates facile methods of functionalization by using nanoscale linker molecules to change ... [more ▼]

Biocompatible inorganic nano- and microcarriers can be suitable candidates for protein delivery. This study demonstrates facile methods of functionalization by using nanoscale linker molecules to change the protein adsorption capacity of hydroxyapatite (HA) powder. The adsorption capacity of bovine serum albumin as a model protein has been studied with respect to the surface modifications. The selected linker molecules (lysine, arginine, and phosphoserine) can influence the adsorption capacity by changing the electrostatic nature of the HA surface. Qualitative and quantitative analyses of linker-molecule interactions with the HA surface have been performed by using NMR spectroscopy, zeta-potential measurements, X-ray photoelectron spectroscopy, and thermogravimetric analyses. Additionally, correlations to theoretical isotherm models have been calculated with respect to Langmuir and Freundlich isotherms. Lysine and arginine increased the protein adsorption, whereas phosphoserine reduced the protein adsorption. The results show that the adsorption capacity can be controlled with different functionalization, depending on the protein–carrier selections under consideration. The scientific knowledge acquired from this study can be applied in various biotechnological applications that involve biomolecule–inorganic material interfaces. [less ▲]

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See detailDevelopment, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Mbinze Kidenge, Jérémie; Sacre, Pierre-Yves ULg; Yemoa, Achille et al

in Journal of Pharmaceutical & Biomedical Analysis (2015), 111

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient ... [more ▼]

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and Near Infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50-150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC). [less ▲]

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See detailDrug loading of polymer implants by supercritical CO2 assisted impregnation: a review
Champeau, Mathilde; Thomassin, Jean-Michel ULg; Tassaing, Thierry et al

in Journal of Controlled Release (2015), 209

Drug loaded implants also called drug-eluting implants have proven their benefits over simple implants. Among the developed manufacturing processes, the supercritical CO2 (scCO2) assisted impregnation has ... [more ▼]

Drug loaded implants also called drug-eluting implants have proven their benefits over simple implants. Among the developed manufacturing processes, the supercritical CO2 (scCO2) assisted impregnation has attracted growing attention to load Active Pharmaceutical Ingredients into polymer implants since it enables to recover a final implant free of any solvent residue and to operate under mild temperature which is suitable for processing with thermosensitive drugs. This paper is a review of the state-of-the-art and the application of the scCO2 assisted impregnation process to prepare drug-eluting implants. It introduces the process and presents its advantages for biomedical applications. The influences of the characteristics of the implied binary systems and of the experimental conditions on the drug loading are described. Then, the various current applications of this process for manufacturing drug-eluting implants are reviewed. Finally, the new emerging variations of this process are described. [less ▲]

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See detailCompte rendu de Sagaert (Claudine), Histoire de la laideur féminine
Duchesne, Caroline ULg

in Lectures (2015)

Parcourant les successives perceptions de la laideur féminine de l’Antiquité à nos jours, l’étude que propose Claudine Sagaert, docteur en sociologie, adopte une approche pluridisciplinaire que vient ... [more ▼]

Parcourant les successives perceptions de la laideur féminine de l’Antiquité à nos jours, l’étude que propose Claudine Sagaert, docteur en sociologie, adopte une approche pluridisciplinaire que vient soutenir un riche corpus empruntant à la philosophie, à l’anthropologie, aux sciences médicales et encore à la littérature. [less ▲]

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See detailAn ecosystem-scale perspective of the net land methanol flux: synthesis of micrometeorological flux measurements
Wohlfahrt, G.; Amelynck, C.; Ammann, C. et al

in Atmospheric Chemistry and Physics (2015), (15), 7413-7427

Methanol is the second most abundant volatile organic compound in the troposphere and plays a significant role in atmospheric chemistry. While there is consensus about the dominant role of living plants ... [more ▼]

Methanol is the second most abundant volatile organic compound in the troposphere and plays a significant role in atmospheric chemistry. While there is consensus about the dominant role of living plants as the major source and the reaction with OH as the major sink of methanol, global methanol budgets diverge considerably in terms of source/sink estimates, reflecting uncertainties in the approaches used to model and the empirical data used to separately constrain these terms. Here we compiled micrometeorological methanol flux data from eight different study sites and reviewed the corresponding literature in order to provide a first cross-site synthesis of the terrestrial ecosystem-scale methanol exchange and present an independent data-driven view of the land–atmosphere methanol exchange. Our study shows that the controls of plant growth on production, and thus the methanol emission magnitude, as well as stomatal conductance on the hourly methanol emission variability, established at the leaf level, hold across sites at the ecosystem level. Unequivocal evidence for bi-directional methanol exchange at the ecosystem scale is presented. Deposition, which at some sites even exceeds methanol emissions, represents an emerging feature of ecosystem-scale measurements and is likely related to environmental factors favouring the formation of surface wetness. Methanol may adsorb to or dissolve in this surface water and eventually be chemically or biologically removed from it. Management activities in agriculture and forestry are shown to increase local methanol emission by orders of magnitude; however, they are neglected at present in global budgets. While contemporary net land methanol budgets are overall consistent with the grand mean of the micrometeorological methanol flux measurements, we caution that the present approach of simulating methanol emission and deposition separately is prone to opposing systematic errors and does not allow for full advantage to be taken of the rich information content of micrometeorological flux measurements. [less ▲]

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See detailModes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Hamaïdia, Malik ULg et al

in Viruses (2015), 7

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic ... [more ▼]

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans. [less ▲]

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See detailManagement of demented patients with urinary incontinence: A case study
de Codt, Aloïse; Grotz, Catherine ULg; Degaute, Marie-France et al

in Clinical Neuropsychologist (The) (2015), 29

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See detailShedding Light on the b to s Anomalies
Aristizabal Sierra, Diego ULg; Vicente, Avelino ULg; Staub, Florian

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2015), 92(015001),

The LHCb collaboration has recently reported on some anomalies in b→s transitions. In addition to discrepancies with the Standard Model (SM) predictions in some angular observables and branching ratios ... [more ▼]

The LHCb collaboration has recently reported on some anomalies in b→s transitions. In addition to discrepancies with the Standard Model (SM) predictions in some angular observables and branching ratios, an intriguing hint for lepton universality violation was found. Here we propose a simple model that extends the SM with a dark sector charged under an additional U(1) gauge symmetry. The spontaneous breaking of this symmetry gives rise to a massive Z′ boson, which communicates the SM particles with a valid dark matter candidate, while solving the b→s anomalies with contributions to the relevant observables. [less ▲]

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See detailThe LEECH Exoplanet Imaging Survey. Further constraints on the planet architecture of the HR 8799 system (Corrigendum)
Maire, A.-L.; Skemer, A. J.; Hinz, P. M. et al

in Astronomy and Astrophysics (2015), 579

The LBT is an international collaboration among institutions in the United States, Italy and Germany. LBT Corporation partners are: The University of Arizona on behalf of the Arizona university system ... [more ▼]

The LBT is an international collaboration among institutions in the United States, Italy and Germany. LBT Corporation partners are: The University of Arizona on behalf of the Arizona university system; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max-Planck Society, the Astrophysical Institute Potsdam, and Heidelberg University; The Ohio State University, and The Research Corporation, on behalf of The University of Notre Dame, University of Minnesota, and University of Virginia. [less ▲]

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See detailFodder Biomass Monitoring in Sahelian Rangelands Using Phenological Metrics from FAPAR Time Series
Diouf, Abdoul Aziz; Brandt, Martin; Verger, Aleixandre et al

in Remote sensing (2015), 7(9122-9148),

Timely monitoring of plant biomass is critical for the management of forage resources in Sahelian rangelands. The estimation of annual biomass production in the Sahel is based on a simple relationship ... [more ▼]

Timely monitoring of plant biomass is critical for the management of forage resources in Sahelian rangelands. The estimation of annual biomass production in the Sahel is based on a simple relationship between satellite annual Normalized Difference Vegetation Index (NDVI) and in situ biomass data. This study proposes a new methodology using multi-linear models between phenological metrics from the SPOT-VEGETATION time series of Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) and in situ biomass. A model with three variables—large seasonal integral (LINTG), length of growing season, and end of season decreasing rate—performed best (MAE = 605 kg·DM/ha; R2 = 0.68) across Sahelian ecosystems in Senegal (data for the period 1999–2013). A model with annual maximum (PEAK) and start date of season showed similar performances (MAE = 625 kg·DM/ha; R2 = 0.64), allowing a timely estimation of forage availability. The subdivision of the study area in ecoregions increased overall accuracy (MAE = 489.21 kg·DM/ha; R2 = 0.77), indicating that a relation between metrics and ecosystem properties exists. LINTG was the main explanatory variable for woody rangelands with high leaf biomass, whereas for areas dominated by herbaceous vegetation, it was the PEAK metric. The proposed approach outperformed the established biomass NDVI-based product (MAE = 818 kg·DM/ha and R2 = 0.51) and should improve the operational monitoring of forage resources in Sahelian rangelands. [less ▲]

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See detailL’importance aux yeux de Strasbourg de l’effectivité des recours indemnitaires et préventifs en cas de dépassement du délai raisonnable
Michiels, Olivier ULg; Falque, Géraldine ULg

in Revue Trimestrielle des Droits de l'Homme (2015), (2015/103), 741-758

The Belgian Government, on whom the burden of proof lies, has not shown that this compensatory remedy is garanteed in practice by the courts in the context of criminal proceedings. Accordingly, the remedy ... [more ▼]

The Belgian Government, on whom the burden of proof lies, has not shown that this compensatory remedy is garanteed in practice by the courts in the context of criminal proceedings. Accordingly, the remedy as currently organised in Belgium cannot be regarded as an effective means of complaining about the length of the criminal judicial investigation. The preventive remedies cannot, therefore, be regarded as effective in the present case. In fact, the Court noted that none of the measures in question was specifically directed at the delay which was the object of complaint. [less ▲]

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See detailFrom the ocean to a reef habitat: How do the larvae of coral reef fishes find their way home? A state of art on the latest advances
Barth, P; Berenshtein, I; Besson, M et al

in Vie et Milieu (2015), 65(2), 91-100

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See detailQuantitatively mimicking wet colloidal suspensions with dry granular media
Messina, René; Aljawhari, Sarah; Bécu, Lydiane et al

in Scientific Reports (2015)

Athermal two-dimensional granular systems are exposed to external mechanical noise leading to Brownian-like motion. Using tunable repulsive interparticle interaction, it is shown that the same ... [more ▼]

Athermal two-dimensional granular systems are exposed to external mechanical noise leading to Brownian-like motion. Using tunable repulsive interparticle interaction, it is shown that the same microstructure as that observed in colloidal suspensions can be quantitatively recovered at a macroscopic scale. To that end, experiments on granular and colloidal systems made up of magnetized particles as well as computer simulations are performed and compared. Excellent agreement throughout the range of the magnetic coupling parameter Γ is found for the pair distribution as well as the bond-orientational correlation functions. This finding opens new ways to efficiently and very conveniently explore phase transitions, crystallization, nucleation, etc in confined geometries. [less ▲]

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See detailThree WASP-South Transiting Exoplanets: WASP-74b, WASP-83b, and WASP-89b
Hellier, Coel; Anderson, D. R.; Collier Cameron, A. et al

in Astronomical Journal (The) (2015), 150

We report the discovery of three new transiting hot Jupiters by WASP-South together with the TRAPPIST photometer and the Euler/CORALIE spectrograph. WASP-74b orbits a star of V = 9.7, making it one of the ... [more ▼]

We report the discovery of three new transiting hot Jupiters by WASP-South together with the TRAPPIST photometer and the Euler/CORALIE spectrograph. WASP-74b orbits a star of V = 9.7, making it one of the brighter systems accessible to southern telescopes. It is a 0.95M[SUB]Jup[/SUB] planet with a moderately bloated radius of 1.5 {R}[SUB]{Jup[/SUB]} in a 2 day orbit around a slightly evolved F9 star. WASP-83b is a Saturn-mass planet at 0.3 {M}[SUB]{Jup[/SUB]} with a radius of 1.0 {R}[SUB]{Jup[/SUB]}. It is in a 5 day orbit around a fainter (V = 12.9) G8 star. WASP-89b is a 6 M[SUB]Jup[/SUB] planet in a 3 day orbit with an eccentricity of e = 0.2. It is thus similar to massive, eccentric planets such as XO-3b and HAT-P-2b, except that those planets orbit F stars whereas WASP-89 is a K star. The V = 13.1 host star is magnetically active, showing a rotation period of 20.2 days, while star spots are visible in the transits. There are indications that the planet’s orbit is aligned with the stellar spin. WASP-89 is a good target for an extensive study of transits of star spots. [less ▲]

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See detailErratum: Rotation, spectral variability, magnetic geometry and magnetosphere of the Of?p star CPD -28° 2561
Wade, G. A.; Barbá, R. H.; Grunhut, J. et al

in Monthly Notices of the Royal Astronomical Society (2015), 450

Not Available

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See detailWASP-80b has a dayside within the T-dwarf range
Triaud, Amaury H. M. J.; Gillon, Michaël ULg; Ehrenreich, David et al

in Monthly Notices of the Royal Astronomical Society (2015), 450

WASP-80b is a missing link in the study of exoatmospheres. It falls between the warm Neptunes and the hot Jupiters and is amenable for characterization, thanks to its host star's properties. We observed ... [more ▼]

WASP-80b is a missing link in the study of exoatmospheres. It falls between the warm Neptunes and the hot Jupiters and is amenable for characterization, thanks to its host star's properties. We observed the planet through transit and during occultation with Warm Spitzer. Combining our mid-infrared transits with optical time series, we find that the planet presents a transmission spectrum indistinguishable from a horizontal line. In emission, WASP-80b is the intrinsically faintest planet whose dayside flux has been detected in both the 3.6 and 4.5 μm Spitzer channels. The depths of the occultations reveal that WASP-80b is as bright and as red as a T4 dwarf, but that its temperature is cooler. If planets go through the equivalent of an L-T transition, our results would imply that this happens at cooler temperatures than for brown dwarfs. Placing WASP-80b's dayside into a colour-magnitude diagram, it falls exactly at the junction between a blackbody model and the T-dwarf sequence; we cannot discern which of those two interpretations is the more likely. WASP-80b's flux density is as low as GJ 436b at 3.6 μm; the planet's dayside is also fainter, but bluer than HD 189733Ab's nightside (in the [3.6] and [4.5]Spitzer bands). Flux measurements on other planets with similar equilibrium temperatures are required to establish whether irradiated gas giants, such as brown dwarfs, transition between two spectral classes. An eventual detection of methane absorption in transmission would also help lift that degeneracy. We obtained a second series of high-resolution spectra during transit, using HARPS. We reanalyse the Rossiter-McLaughlin effect. The data now favour an aligned orbital solution and a stellar rotation nearly three times slower than stellar line broadening implies. A contribution to stellar line broadening, maybe macroturbulence, is likely to have been underestimated for cool stars, whose rotations have therefore been systematically overestimated. [less ▲]

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See detailVersion française de la Distress Tolerance Scale et de la Discomfort Intolerance Scale
Wagener, Aurélie ULg; Blairy, Sylvie ULg

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2015), 3(47),

The perceived perspective of the distress tolerance refers to the perceived ability to experience and to withstand negative emotional states and/or other aversive sensations (e.g. physical discomfort ... [more ▼]

The perceived perspective of the distress tolerance refers to the perceived ability to experience and to withstand negative emotional states and/or other aversive sensations (e.g. physical discomfort). Two scales were developed to assess this construct: the Distress Tolerance Scale (DTS) and the Discomfort Intolerance Scale (DIS). The objective of this investigation is to present the validation of these two scales in French. 488 non-clinical adults completed an online survey assessing the distress tolerance and emotional regulation strategies. Factor analyses were performed to determine the factor structures of the French versions of these scales. CFA highlighted a four-factor solution (tolerance, absorption, appraisal, regulation) with one higher-order factor (general distress tolerance) as being the better fit for the DTS. CFA highlighted a two-factor solution (intolerance and avoidance) with one higher-order factor (general discomfort intolerance) as being the better fit for the DIS. Intern and extern validity were assessed and demonstrated good properties. [less ▲]

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See detailBiomechanical Analysis of Abdominal Injury in Tennis Serves. A Case Report
Tubez, François ULg; Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg et al

in Journal of Sports Science & Medicine (2015), 14

The serve is an important stroke in any high level tennis game. A well-mastered serve is a substantial advantage for players. However, because of its repeatability and its intensity, this stroke is ... [more ▼]

The serve is an important stroke in any high level tennis game. A well-mastered serve is a substantial advantage for players. However, because of its repeatability and its intensity, this stroke is potentially deleterious for upper limbs, lower limbs and trunk. The trunk is a vital link in the production and transfer of energy from the lower limbs to the upper limbs; therefore, kin-ematic disorder could be a potential source of risk for trunk injury in tennis. This research studies the case of a professional tennis player who has suffered from a medical tear on the left rectus abdominis muscle after tennis serve. The goal of the study is to understand whether the injury could be explained by an inappropriate technique. For this purpose, we analyzed in three dimensions the kinematic and kinetic aspects of the serve. We also performed isokinetic tests of the player’s knees. We then compared the player to five other professional players as refer-ence. We observed a possible deficit of energy transfer because of an important anterior pelvis tilt. Some compensation made by the player during the serve could be a possible higher abdominal contraction and a larger shoulder external rotation. These partic-ularities could induce an abdominal overwork that could explain the first injury and may provoke further injuries. [less ▲]

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See detailPolarization alignments of quasars from the JVAS/CLASS 8.4-GHz surveys
Pelgrims, Vincent ULg; Hutsemekers, Damien ULg

in Monthly Notices of the Royal Astronomical Society (2015), 450

We test the hypothesis that the polarization vectors of flat-spectrum radio sources (FSRSs) from the JVAS/CLASS 8.4-GHz surveys are randomly oriented in the sky. A sample with robust polarization ... [more ▼]

We test the hypothesis that the polarization vectors of flat-spectrum radio sources (FSRSs) from the JVAS/CLASS 8.4-GHz surveys are randomly oriented in the sky. A sample with robust polarization measurements is made with 4155 objects. Redshift information is known for 1531 of them. We performed two statistical analyses: one in two dimensions and the other in three dimensions when distance is available. We find significant large-scale alignments of polarization vectors for samples containing only quasars among the varieties of FSRS. While these correlations prove difficult to explain either by a physical effect or by biases in the data set, that the quasars that have significantly aligned polarization vectors are found in regions of the sky where optical polarization alignments were previously found is striking. [less ▲]

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See detailHousing Quality as Environmental Inequality: The Case of Wallonia, Belgium
Lejeune, Zoé ULg; Xhignesse, Guillaume ULg; Kryvobokov, Marko et al

in Journal of Housing and the Built Environment (2015)

First in the USA and then in many other countries, scholarship on environmental inequality has sought to shed light on the unequal environmental conditions borne by poor people and ethnic minorities, and ... [more ▼]

First in the USA and then in many other countries, scholarship on environmental inequality has sought to shed light on the unequal environmental conditions borne by poor people and ethnic minorities, and to challenge public policies and their unjust impacts on those target groups. Housing quality, especially the indoor characteristics of homes, offers an innovative perspective in this field of research. In previous research on environmental inequality in the Walloon context, housing quality has been proven to be a major determinant of quality of life and environmental well-being. This paper analyses housing quality through a twofold approach: through indoor characteristics on the one hand, and outdoor subjective and objective externalities on the other. It reveals the disparities between the most deprived and the wealthiest segments of the population. The evidence for this study is based on a housing quality survey carried out in 2012 and 2013 on 6,018 households in Wallonia (Belgium). The key findings are that poor people are found to live in housing of lower quality, in densely populated neighbourhoods and those with mixed use, with compensating amenities provided at the local level. Moreover, consistent with environmental inequality scholarship, deprived households are found to bear the burden of environmental degradation outside the home. People live in areas with poorer air quality, but are found to benefit from greater access to green spaces. The results of the survey reveal an interesting point concerning the environmental inequality literature; the interior features of housing are found to differ more widely between deprived and wealthier people than the surrounding environment does. [less ▲]

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See detailSize effects and temperature dependence on strain-hardening mechanisms in some face centered cubic materials
HUG, E.; DUBOS, P.A.; keller, C. et al

in Mechanics of Materials (2015), 91

The mechanical behaviour of face centered cubic metals is deeply affected when specimen dimensions decrease from a few The millimeters to a few micrometers. At room temperature, a critical thickness (t ... [more ▼]

The mechanical behaviour of face centered cubic metals is deeply affected when specimen dimensions decrease from a few The millimeters to a few micrometers. At room temperature, a critical thickness (t) to grain size (d) ratio (t/d)c, was previously highlighted, under which the sofiening of mechanical properties became very pronounced both in terms of Hall-Petch relation and work hardening mechanisms. In this work, new experimental results are provided concerning the influence of temperature on this size effect for copper, nickel and Ni-20wt.%Cr, representative of a wide range of deformation mechanisms (i.e. dislocation slip character). It is shown that multicrystalline samples (t/d < (t/d)c) are not deeply affected by an increase in temperature, independently of the planar or wavy character of dislocation glide. For pronounced wavy slip character metals, surface effects in polycrystals (t/d > (t/d)c) are not significant enough to reduce the gap between polycrystal and multierystal mechanical behaviour when the temperature increases. However, a transition from wavy slip to planar glide mechanisms induces a modification ofthe polycrystalline behaviour which tends tovard multicrystalline one with a moderate increase in temperature. This work demonstrates that surface effects and grain size influence can be successfully disassociated for the three studied materials using an analysis supported by the Kooks- Mecking formalism. All these results are supported by microscopic investigations of dislocation substructures and compared to numerical simulations using a stress gradient plasticity model. [less ▲]

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See detailLa Belgique ‘officielle’ face à l’OAS (1961-1964). Cas d’une adaptation de Bruxelles à la politique du général De Gaulle
Genin, Vincent ULg

in Revue du Nord (2015), 406 (octobre-décembre 2014)(96), 917-935

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See detailExperimental and numerical study of the flight of geese
Dimitriadis, Grigorios ULg; Gardiner, James; Tickle, Peter et al

in Aeronautical Journal (2015), 119(1217), 1-30

The flight of barnacle geese at airspeeds representing high-speed migrating flight is investigated using experiments and simulations. The experimental part of the work involved the filming of three ... [more ▼]

The flight of barnacle geese at airspeeds representing high-speed migrating flight is investigated using experiments and simulations. The experimental part of the work involved the filming of three barnacle geese (Branta Leucopsis) flying at different airspeeds in a wind tunnel. The video footage was analysed in order to extract the wing kinematics. Additional information, such as wing geometry and camber was obtained from a 3D scan of a dried wing. An unsteady vortex lattice method was used to simulate the aerodynamics of the measured flapping motion. The simulations were used in order to successfully reproduce the measured body motion and thus obtain estimates of the aerodynamic forces acting on the wings. It was found that the mean of the wing pitch angle variation with time has the most significant effect on lift while the difference in the durations of the upstroke and downstroke has the major effect on thrust. The power consumed by the aerodynamic forces was also estimated; it was found that increases in aerodynamic power correspond very closely to climbing motion and vice versa. Root-mean-square values of the power range from 100 W to 240 W. Finally, it was observed that tandem flying can be very expensive for the trailing bird. [less ▲]

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See detailConnections between the design tool, design attributes, and user preferences in early stage design
Häggman, Anders; Tsai, Geoff; Elsen, Catherine ULg et al

in Journal of Mechanical Design (2015), 137(7), 13

Gathering user feedback on provisional design concepts early in the design process has the potential to reduce time-to-market and create more satisfying products. Among the parameters that shape user ... [more ▼]

Gathering user feedback on provisional design concepts early in the design process has the potential to reduce time-to-market and create more satisfying products. Among the parameters that shape user response to a product, this paper investigates how design experts use sketches, physical prototypes, and computer-aided design (CAD) to generate and represent ideas, as well as how these tools are linked to design attributes and multiple measures of design quality. Eighteen expert designers individually addressed a 2 hr design task using only sketches, foam prototypes, or CAD. It was found that prototyped designs were generated more quickly than those created using sketches or CAD. Analysis of 406 crowdsourced responses to the resulting designs showed that those created as prototypes were perceived as more novel, more aesthetically pleasing, and more comfortable to use. It was also found that designs perceived as more novel tended to fare poorly on all other measured qualities. [less ▲]

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See detailVitesse ou précipitation ? La question du temps dans le traitement des affaires pénales en France et en Belgique
Bastard, Benoit; Delvaux, David ULg; Mouhanna, Christian et al

in Droit et Société (2015), 90

Le temps a changé de valeur dans le fonctionnement des institutions pénales. La réponse instantanée à toute sollicitation est devenue l’objectif prioritaire dans le travail des parquets. L’efficacité de ... [more ▼]

Le temps a changé de valeur dans le fonctionnement des institutions pénales. La réponse instantanée à toute sollicitation est devenue l’objectif prioritaire dans le travail des parquets. L’efficacité de la réponse pénale impose de rapprocher autant que possible le temps de la sanction de celui de l’infraction. Les normes de bonne gestion publique passent par la quantification des affaires et la réduction des délais de traitement. Cette tendance générale est observée ici dans une perspective comparative : France et Belgique. Alors que, dans les deux pays, les discours tenus mettent uniformément l’accent sur l’efficacité accrue des services, les comparaisons effectuées font ressortir des décalages importants dans les modalités du traitement rapide. Une réflexion générale peut alors être engagée sur les régimes de changement qui prévalent au sein de l’institution judiciaire dans les deux pays. [less ▲]

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See detailL'éveil de la matrix-gla-protéine sonnera le glas des calcifications vasculaires
DELANAYE, Pierre ULg; Liabeuf, Sophie; BOUQUEGNEAU, Antoine ULg et al

in Néphrologie & Thérapeutique (2015), 11(4), 191-200

La matrix-gla-protéine (MGP) est principalement sécrétée par les chondrocytes et les cellules musculaires lisses des parois vasculaires. Son rôle est d’inhiber localement le développement des ... [more ▼]

La matrix-gla-protéine (MGP) est principalement sécrétée par les chondrocytes et les cellules musculaires lisses des parois vasculaires. Son rôle est d’inhiber localement le développement des calcifications vasculaires. MGP doit bénéficier de deux processus post-transcriptionnels avant d’être pleinement active : une phosphorylation de résidus sérine et une carboxylation de résidus glutamate. Cette carboxylation ne peut se faire qu’en présence de quantité suffisante de vitamine K. Plusieurs formes de MGP circulent donc dans le plasma, certaines étant totalement inactives (la MGP déphosphorylée et décarboxylée), d’autres possédant une activité biologique variable en fonction du nombre de sites carboxylés ou phosphorylés. Il existe un lien théorique étroit entre MGP, vitamine K, calcifications vasculaires et maladies cardiovasculaires et ce, particulièrement chez les patients souffrant d’insuffisance rénale chronique, a fortiori s’ils sont dialysés. Si l’existence de ce lien a été démontrée via de nombreuses et solides données fondamentales, les données cliniques restent, à ce jour, observationnelles et doivent donc être interprétées avec prudence. Mesurer une fraction de MGP dans le plasma pour estimer le degré de calcification d’un patient donné n’est pas encore d’actualité . La forme inactive pourrait être utile pour juger des réserves en vitamine K au niveau vasculaire. Dans cet article de revue, nous reviendrons sur les bases théoriques du rôle de MGP dans le processus de calcification vasculaire, sur le défi analytique que représente sa détermination dans le plasma, ainsi que sur les liens entre MGP, vitamine K et calcifications vasculaires en population géne´ rale et chez les patients insuffisants rénaux. [less ▲]

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See detailInfluence of soft ferromagnetic sections on the magnetic flux density profile of a large grain, bulk Y-Ba-Cu-O superconductor
Philippe, Matthieu ULg; Ainslie, Mark D; Wera, Laurent ULg et al

in Superconductor Science and Technology (2015), 28

Bulk, high temperature superconductors have significant potential for use as powerful permanent magnets in a variety of practical applications due to their ability to trap record magnetic fields. In this ... [more ▼]

Bulk, high temperature superconductors have significant potential for use as powerful permanent magnets in a variety of practical applications due to their ability to trap record magnetic fields. In this paper, soft ferromagnetic sections are combined with a bulk, large grain Y-Ba-Cu-O (YBCO) high temperature superconductor to form superconductor/ferromagnet (SC/FM) hybrid structures. We study how the ferromagnetic sections influence the shape of the profile of the trapped magnetic induction at the surface of each structure and report the surface magnetic flux density measured by Hall probe mapping. These configurations have been modelled using a 2D axisymmetric finite element method based on the H-formulation and the results show excellent qualitative and quantitative agreement with the experimental measurements. The model has also been used to study the magnetic flux distribution and predict the behaviour for other constitutive laws and geometries. The results show that the ferromagnetic material acts as a magnetic shield, but the flux density and its gradient are enhanced on the face opposite to the ferromagnet. The thickness and saturation magnetization of the ferromagnetic material are important and a characteristic ferromagnet thickness d* is derived: below d*, saturation of the ferromagnet occurs, and above d*, a weak thickness-dependence is observed. The influence of the ferromagnet is observed even if its saturation magnetization is lower than the trapped flux density of the superconductor. Conversely, thin ferromagnetic discs can be driven to full saturation even though the outer magnetic field is much smaller than their saturation magnetization. [less ▲]

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See detailCerebral functional connectivity periodically (de)synchronizes with anatomical constraints
Liegeois, Raphaël ULg; Ziegler, Erik; Bahri, Mohamed Ali ULg et al

in Brain Structure and Function (2015)

This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber ... [more ▼]

This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of the fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis based on the correlation between SC and the FC averaged over the entire fMRI time series, we propose a dynamic analysis, based on the time evolution of the correlation between SC and a suitably windowed FC. Assessing the statistical significance of the time series against random phase permutations, our data show a pronounced peak of significance for time window widths around 20-30 TR (40-60 sec). Using the appropriate window width, we show that FC patterns oscillate between phases of high modularity, primarily shaped by anatomy, and phases of low modularity, primarily shaped by inter-network connectivity. Building upon recent results in dynamic FC, this emphasizes the potential role of SC as a transitory architecture between different highly connected resting state FC patterns. Finally, we show that networks implied in consciousness-related processes, such as the default mode network (DMN), contribute more to these brain-level fluctuations compared to other networks, such as the motor or somatosensory networks. This suggests that the fluctuations between FC and SC are capturing mind-wandering effects. [less ▲]

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See detailHepatozoonosis in cats : ABCD guidelines on prevention and management
Lloret, A.; Addie, D.D.; Boucraut-Baralon, C. et al

in Journal of Feline Medicine and Surgery (2015), 17

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See detailMatrix vaccination guidelines : 2015 ABCD recommendations for indoor/outdoor cats, rescue shelter cats and breeding catteries
Hosie, M.J.; Addie, D.D.; Boucraut-Baralon, C. et al

in Journal of Feline Medicine and Surgery (2015), 17

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See detailDetection of decomposition volatile organic compounds in soil following removal of remains from a surface deposition site
Perrault, Katelynn A.; Stefanuto, Pierre-Hugues ULg; Stuart, Barbara H. et al

in Forensic Science, Medicine & Pathology (2015), 11(3), 376-387

Purpose Cadaver-detection dogs use volatile organic compounds (VOCs) to search for human remains including those deposited on or beneath soil. Soil can act as a sink for VOCs, causing loading of ... [more ▼]

Purpose Cadaver-detection dogs use volatile organic compounds (VOCs) to search for human remains including those deposited on or beneath soil. Soil can act as a sink for VOCs, causing loading of decomposition VOCs in the soil following soft tissue decomposition. The objective of this study was to chemically profile decomposition VOCs from surface decomposition sites after remains were removed from their primary location. Methods Pig carcasses were used as human analogues and were deposited on a soil surface to decompose for 3 months. The remains were then removed from each site and VOCs were collected from the soil for 7 months & Katelynn A. Perrault katelynn.perrault@uts.edu.au thereafter and analyzed by comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry (GC9GC–TOFMS). Results Decomposition VOCs diminished within 6 weeks and hydrocarbons were the most persistent compound class. Decomposition VOCs could still be detected in the soil after 7 months using Principal Component Analysis. Conclusions This study demonstrated that the decompo- sition VOC profile, while detectable by GC9GC–TOFMS in the soil, was considerably reduced and altered in com- position upon removal of remains. Chemical reference data is provided by this study for future investigations of canine alert behavior in scenarios involving scattered or scav- enged remains. [less ▲]

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