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See detailcompte rendu de : Pascale PARÉ-REY, Flores et acumina. Les sententiae dans les tragédies de Sénèque
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (2014)

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See detailHybridization capture using short PCR products enriches small genomes by capturing flanking sequences (CapFlank)
Tsangaras, K.; Wales, N.; Sicheritz-Pontén, T. et al

in PLoS ONE (2014), 9(10),

Solution hybridization capture methods utilize biotinylated oligonucleotides as baits to enrich homologous sequences from next generation sequencing (NGS) libraries. Coupled with NGS, the method generates ... [more ▼]

Solution hybridization capture methods utilize biotinylated oligonucleotides as baits to enrich homologous sequences from next generation sequencing (NGS) libraries. Coupled with NGS, the method generates kilo to gigabases of high confidence consensus targeted sequence. However, in many experiments, a non-negligible fraction of the resulting sequence reads are not homologous to the bait. We demonstrate that during capture, the bait-hybridized library molecules add additional flanking library sequences iteratively, such that baits limited to targeting relatively short regions (e.g. few hundred nucleotides) can result in enrichment across entire mitochondrial and bacterial genomes. Our findings suggest that some of the off-target sequences derived in capture experiments are non-randomly enriched, and that CapFlank will facilitate targeted enrichment of large contiguous sequences with minimal prior target sequence information. [less ▲]

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See detailThe anagenetic world of spore-producing land plants
Patino Llorente, Jairo ULg; Carine, M.A.; Fernández-Palacios, J.M. et al

in New Phytologist (2014), 201

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See detailHost-induced bacterial cell wall decomposition mediates pattern-triggered immunity in Arabidopsis
Liu, X.; Grabherr, H.; Willmann, R. et al

in eLife (2014)

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See detailA propos de l'encéphalopathie du nouveau-né
Battisti, Oreste ULg; Beguin, Yves ULg

in Percentile (2014), 19

Editorial sur l'hypoxie périnatale et les cellules souches.

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See detailEcosystem services of mixed species forest stands and monocultures: comparing practitioners' and scientists' perceptions with formal scientific knowledge
Carnol, Monique ULg; Baeten, Lander; Branquart, Etienne et al

in Forestry (2014)

Mixed species stands might contribute to important goals of sustainable forest management, such as higher biological diversity, more resistance and resilience to disturbances and higher carbon storage ... [more ▼]

Mixed species stands might contribute to important goals of sustainable forest management, such as higher biological diversity, more resistance and resilience to disturbances and higher carbon storage. Knowledge of stakeholders' perceptions of such ecosystem services in mixed species stands is required for effective policy development. We showed that practitioners' and scientists' perceptions of ecosystem services in mixed species stands in Belgium differed from formal scientific knowledge derived from a synthesis of published studies. The positive perception of supporting, regulating and cultural services in mixed species stands contrasted with less conclusive results from the literature, where positive, negative and neutral effects were reported. Many respondents also signified a lack of information about regulating services. Furthermore, provisioning services were perceived as equal in mixed species stands and monocultures, in contrast to higher productivity demonstrated in mixed species stands in the literature. The regional (Flanders and Wallonia) ecological and socio-economic context influenced both the perception of ecosystem services and of the importance of management objectives. Our results highlighted the need to address the lack of scientific data, to adapt communication to the ecological and socio-economic context, as well as to improve information flow on regulating services and productivity. [less ▲]

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See detailThe threshold photoelectron spectroscopy of the cis- and trans-1-chloro-2-fluoro-ethene isomers. An experimental and quantum chemical study.
Locht, Robert ULg; Dehareng, Dominique ULg; Leyh, Bernard ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (2014), 47(17), 175101-175012

The threshold photoelectron spectra (TPES) of the two vicinal isomers of the 1,2-C2H2FCl molecule have been investigated in the 9-24 eV energy range using synchrotron radiation. Eight (for the cis-isomer ... [more ▼]

The threshold photoelectron spectra (TPES) of the two vicinal isomers of the 1,2-C2H2FCl molecule have been investigated in the 9-24 eV energy range using synchrotron radiation. Eight (for the cis-isomer) or nine (for the trans-isomer) bands have been observed and the corresponding ionization energies have been determined. The spectroscopic assignments are based on high level quantum chemical ab initio calculations for both isomers. Most of the observed spectral features could be interpreted. For both species the first three TPES bands exhibit a rich vibrational structure. Vibrational energies were determined and assignments were also supported by quantum chemical calculations of vibrational wavenumbers for these three ionic states of both isomers. [less ▲]

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See detailRisk ranking priority of carcinogenic and/or genotoxic environmental contaminants in food in Belgium
Vromman, V; Maghuin-Rogister, Guy ULg; Vleminckx, C et al

in Food Additives & Contaminants. Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment (2014)

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See detailPlant selection for nest building by western lowland gorillas in Cameroon
Willie, Jacob; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Primates : Journal of Primatology (2014)

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See detailDorsomedial prefrontal metabolism and unawareness of current characteristics of personality traits in Alzheimer’s disease
Jedidi, Haroun ULg; Feyers, Dorothée ULg; Collette, Fabienne ULg et al

in Social Cognitive and Affective Neuroscience (2014)

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while ... [more ▼]

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while unawareness of current characteristics of personality traits has rarely been considered. We used a well-established questionnaire-based method in a group of 37 AD patients and in healthy controls to probe self- and hetero-evaluation of patients’ personality and we calculated differential scores between each participant’s and his/her relative’s judgments. A brain-behavior correlation was performed using FDG-PET images. The behavioral data showed that AD patients presented with anosognosia for current characteristics of their personality and their anosognosia was primarily explained by impaired third perspective taking. The brain-behavior correlation analysis revealed a negative relationship between anosognosia for current characteristics of personality and dorsomedial prefrontal cortex (dMPFC) activity. Behavioral and neuroimaging data are consistent with the view that impairment of different functions subserved by the dMPFC (self-evaluation, inferences regarding complex enduring dispositions of self and others, confrontation of perspectives in interpersonal scripts) plays a role in anosognosia for current characteristics of personality in AD patients. [less ▲]

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See detailThe Rank Minrelation Coefficient
Meyer, Patrick ULg

in Quality Technology & Quantitative Management (2014), 11

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See detailVie, langage, matérialité: les stratégies de civilité du cinéma de Kechiche
Janvier, Antoine ULg

in Cahiers du GRM (2014), 5

Partant d'une analyse des quatre premiers films de Kechiche, en particulier de "La faute à Voltaire", "L’esquive" et "La graine et le mulet", ce texte s'efforce de penser les modalités et les conséquences ... [more ▼]

Partant d'une analyse des quatre premiers films de Kechiche, en particulier de "La faute à Voltaire", "L’esquive" et "La graine et le mulet", ce texte s'efforce de penser les modalités et les conséquences du traitement cinématographique proposé par Abdellatif Kechiche de la vie ou de l’existence humaine depuis le problème que pose leur limite. On verra qu’il y va d’une certaine conception et perception de la violence, et d’une exploration soutenue et attentive de l’épaisseur affective, proto- ou para-politique, de nos formations sociales. [less ▲]

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See detailMultitasking capacities in persons diagnosed with schizophrenia: A preliminary examination of their neurocognitive underpinnings and ability to predict real world functioning
Laloyaux, Julien ULg; Van der Linden, Martial ULg; Levaux, Marie-Noëlle ULg et al

in Psychiatry Research (2014), 217

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia and in particular during multitasking activities. However, at present, patients' multitasking capacities ... [more ▼]

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia and in particular during multitasking activities. However, at present, patients' multitasking capacities have not been adequately examined in the literature due to an absence of suitable assessment strategies. We thus recently developed a computerized real-life activity task designed to take into account the complex and multitasking nature of certain everyday life activities where participants are required to prepare a room for a meeting. Twenty-one individuals diagnosed with schizophrenia and 20 matched healthy controls completed the computerized task. Patients were also evaluated with a cognitive battery, measures of symptomatology and real world functioning. To examine the ecological validity, 14 other patients were recruited and were given the computerized version and a real version of the meeting preparation task. Results showed that performance on the computerized task was significantly correlated with executive functioning, pointing to the major implication of these cognitive processes in multitasking situations. Performance on the computerized task also significantly predicted up to 50% of real world functioning. Moreover, the computerized task demonstrated good ecological validity. These findings suggest the importance of evaluating multitasking capacities in patients diagnosed with schizophrenia in order to predict real world functioning. [less ▲]

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See detailA Statistically adaptive sampling policy to the Hotelling's T2 Control Chart: Markov Chain Approach
Seif, A.; Faraz, Alireza ULg; Heuchenne, Cédric ULg et al

in Communications in Statistics : Theory & Methods (2014)

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See detailquelques messages choisis de l'ECCO 17
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2014), 8(1), 8-11

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See detailSerum Vascular Endothelial Growth Factor is Selectively Upregulated in Patients with Biopsy-Proven Giant Cell Arteritis
Morlet, Julien; Mahoney, David; Zarei, Ali et al

in Rheumatology (2014), 53(1), 188-188

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See detailDetermination of kinetics and the crystal structure of a novel type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase from Streptococcus pneumoniae.
de Ruyck, Jerome; Janczak, Matthew W.; Neti, Syam Sundar et al

in Chembiochem : a European journal of chemical biology (2014), 15(10), 1452-1458

Isopentenyl diphosphate isomerase (IDI) is a key enzyme in the isoprenoid biosynthetic pathway and is required for all organisms that synthesize isoprenoid metabolites from mevalonate. Type 1 IDI (IDI-1 ... [more ▼]

Isopentenyl diphosphate isomerase (IDI) is a key enzyme in the isoprenoid biosynthetic pathway and is required for all organisms that synthesize isoprenoid metabolites from mevalonate. Type 1 IDI (IDI-1) is a metalloprotein that is found in eukaryotes, whereas the type 2 isoform (IDI-2) is a flavoenzyme found in bacteria that is completely absent from human. IDI-2 from the pathogenic bacterium Streptococcus pneumoniae was recombinantly expressed in Escherichia coli. Steady-state kinetic studies of the enzyme indicated that FMNH2 (KM =0.3 muM) bound before isopentenyl diphosphate (KM =40 muM) in an ordered binding mechanism. An X-ray crystal structure at 1.4 A resolution was obtained for the holoenzyme in the closed conformation with a reduced flavin cofactor and two sulfate ions in the active site. These results helped to further approach the enzymatic mechanism of IDI-2 and, thus, open new possibilities for the rational design of antibacterial compounds against sequence-similar and structure-related pathogens such as Enterococcus faecalis or Staphylococcus aureus. [less ▲]

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See detailMechanism of the medium-duration afterhyperpolarization in rat serotonergic neurons
Alix, Philippe ULg; Venkatesan, Kumar; Scuvée-Moreau, Jacqueline et al

in European Journal of Neuroscience (2014), 39(2), 186-196

Most serotonergic neurons display a prominent medium-duration afterhyperpolarization (mAHP), which is mediated by small conductance Ca2+-activated K+ (SK) channels. Recent ex vivo and in vivo experiments ... [more ▼]

Most serotonergic neurons display a prominent medium-duration afterhyperpolarization (mAHP), which is mediated by small conductance Ca2+-activated K+ (SK) channels. Recent ex vivo and in vivo experiments have suggested that SK channel blockade increases the firing rate and/or bursting in these neurons. The purpose of this study was therefore to characterize the source of Ca2+ which activates the mAHP channels in serotonergic neurons. In voltage clamp experiments, an outward current was recorded at -60 mV after a depolarizing pulse to + 100 mV. A supra-maximal concentration of the SK channel blockers apamin or (-)- bicuculline methiodide blocked this outward current. This current was also sensitive to the broad Ca2+ channel blocker Co2+ and was partially blocked by both ω-conotoxin and mibefradil, which are blockers of N-type and T-type Ca2+ channels, respectively. Neither blockers of other voltage-gated Ca2+ channels nor DBHQ, an inhibitor of Ca2+-induced Ca2+ release, had any effect on the SK current. [less ▲]

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See detailBrains creating stories of selves: the neural basis of autobiographical reasoning.
D'Argembeau, Arnaud ULg; Cassol, Helena; Phillips, Christophe ULg et al

in Social Cognitive and Affective Neuroscience (2014), 9

Personal identity critically depends on the creation of stories about the self and one's life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the ... [more ▼]

Personal identity critically depends on the creation of stories about the self and one's life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the construction of such narratives. During fMRI scanning, participants approached a set of personally significant memories in two different ways: on some trials, they remembered the concrete content of the events (autobiographical remembering), whereas on other trials they reflected on the broader meaning and implications of their memories (autobiographical reasoning). Relative to remembering, autobiographical reasoning recruited a left-lateralized network involved in conceptual processing (including the dorsal medial prefrontal cortex (MPFC), inferior frontal gyrus, middle temporal gyrus, and angular gyrus). The ventral MPFC-an area that may function to generate personal/affective meaning-was not consistently engaged during autobiographical reasoning across participants but, interestingly, the activity of this region was modulated by individual differences in interest and willingness to engage in self-reflection. These findings support the notion that autobiographical reasoning and the construction of personal narratives go beyond mere remembering in that they require deriving meaning and value from past experiences. [less ▲]

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See detailReview of: D. Zahavi (ed.), The Oxford Handbook of Contemporary Phenomenology (Oxford, 2012)
Seron, Denis ULg

in Husserl Studies (2014), 30(2), 277-281

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See detailLate Quaternary evolution of sediment provenances in the Central
Fagel, Nathalie ULg; Not, Christelle; Gueibe, Jonathan et al

in Quaternary Science Reviews (2014), 92

Mineral assemblage, trace element content and Nd and Pb isotope signatures were analysed on the fine fraction (<20 mm) of sedimentary records from the Northern Mendeleev Ridge in the Central Arctic Ocean ... [more ▼]

Mineral assemblage, trace element content and Nd and Pb isotope signatures were analysed on the fine fraction (<20 mm) of sedimentary records from the Northern Mendeleev Ridge in the Central Arctic Ocean. Our aimwas to identify the detrital particle provenance and to interpret the changes over the past w250 ka in the relative contribution of the different source-areas in relation to paleoenvironmental conditions. The clay mineral assemblage and the Nd and Pb isotope signatures depict systematic changes over the Late Quaternary. The bulk mineralogy exhibits increases in the relative contribution of carbonate minerals vs. silicates in interglacial/deglacial intervals. In glacial intervals, the mineral assemblage of the <20 mm fraction is characterised by an enrichment in kaolinite, counterbalanced by a decrease in illite. The Nd and Pb isotope signatures of <20 mm fraction are interpreted using a three end-member mixing model, involving crustal supplies from North America and Canada, from the Siberian margin and some from volcanic material. A compilation of geochemical signatures of geological terraines surrounding the Arctic Ocean allowed each end-member to be assigned a representative signature, averaging the signal of the eroded terraines. The Suspended Particulate Matter (SPM) of the MacKenzie River represents an average signature of the sedimentary supplies delivered from the North American platform and Canadian margin. The SPM of the Lena River reflects the mean sedimentary signature of the Siberian platform. The Okhotsh-Chukotka province from the Eastern border of Siberia is identified as the most probable volcanic source. Late Quaternary evolution of the estimated relative contribution of the three end-members confirms that the sediment provenances in the Central Arctic Ocean remain close to the current conditions during past interglacials/deglacials MIS1e3, MIS5/TII and MIS7/TIII. In contrast, glacial conditions (MIS4 and MIS6) record minimum supplies from the American margin, associated with increased volcanic contribution, to the Mendeleev Ridge core location suggesting a different sea-ice circulation associated with a low sea-level and reduced shelf area. [less ▲]

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See detailGeometric ferroelectricity in fluoroperovskites
Garcia-Castro, A. C.; Spaldin, Nicola A.; Romero, A. H. et al

in Physical Review B (2014), 89

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are ... [more ▼]

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are paraelectric (Pnma phase), we find that many fluoroperovskites have a ferroelectric instability in their high-symmetry cubic structure that is of similar amplitude to that commonly found in oxide perovskites. In contrast to the oxides, however, the fluorides have nominal Born effective charges, indicating a different mechanism for the instability.We show that the instability originates from ionic size effects, and is therefore in most cases largely insensitive to pressure and strain, again in contrast to the oxide perovskites. An exception is NaMnF3, where coherent epitaxial strain matching to a substrate with equal in-plane lattice constants destabilizes the bulk Pnma structure, leading to a ferroelectric, and indeed multiferroic, ground state with an unusual polarization/strain response. [less ▲]

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See detailCharacterization and modeling of a scroll expander with air and ammonia as working fluid
Mendoza, Luis Carlos; Navarro-Esbrí; Bruno, Joan Carles et al

in Applied Thermal Engineering (2014), 70

This paper presents the experimental characterization and modeling of a scroll expander. The expander used here is a scroll compressor modified to work as an expander. It is characterized in two ... [more ▼]

This paper presents the experimental characterization and modeling of a scroll expander. The expander used here is a scroll compressor modified to work as an expander. It is characterized in two experimental setups using air and ammonia as working fluids. The paper studies how the main operating variables (supply pressure and temperature, pressure ratio, rotational speed and lubrication) influence the performance of the scroll expander. A semi-empirical model is proposed to determine the scroll expander performance. This model uses some semi-empirical parameters (such as built-in volume ratio, leakage area and mechanical losses), obtained through experimentation, to calculate the mechanical power, supply mass flow rate and exhaust temperature. Using this semi-empirical model, the deviations in the calculated mechanical power, exhaust temperature and supply mass flow rate are ±9%, ±4 K and ±5% Hz. [less ▲]

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See detaildeltaPlotR: An R package for differential item functioning analysis with Angoff's Delta Plot
Magis, David ULg; Facon, Bruno

in Journal of Statistical Software (2014), 59(1), 1-19

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by ... [more ▼]

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by proposing an optimal threshold selection and by considering several item purification processes. Moreover, to support practical DIF analyses with the delta plot and these improvements, the R package deltaPlotR was also developed. The purpose of this paper is twofold: to outline the delta plot by describing the original method and its recent improvements in a user-oriented way, and to illustrate the structure and performances of the deltaPlotR package. A real data set about language skill assessment is being analyzed as an illustrative example. [less ▲]

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See detailLE CYBERKNIFE AIME LES DEFIS ! Aperçu d'indications pour la radiothérapie extracrânienne robotisée
JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 87-93

Toute l’histoire de la radiothérapie illustre la quête continue vers une distribution de dose la plus haute possible sur la cible tumorale, tout en réduisant au maximum l’irra - diation des tissus sains ... [more ▼]

Toute l’histoire de la radiothérapie illustre la quête continue vers une distribution de dose la plus haute possible sur la cible tumorale, tout en réduisant au maximum l’irra - diation des tissus sains. La radiothérapie en conditions stéréo - taxiques est la suite logique de cette évolution tant au niveau de la précision d’exécution du traitement qu’au niveau de la concentration de la dose, et donc de l’efficacité du traitement. Cette technique a d’abord été mise en application clinique pour des lésions intra-crâniennes. Une radiothérapie de haute précision ne peut être sensible aux mouvements incontrôlés de la cible. Vu la nécessité en clinique d’aborder les mêmes concepts de précision et d’efficacité pour des cibles extra-crâ - niennes, il a fallu développer des solutions qui permettent de tenir compte du mouvement de la cible. Les solutions infor - matiques et robotiques ont été combinées dans le concept du CyberKnife ® . Nous présentons cette technique particulière d’irradiation et voulons faire part de l’expérience des deux premières années acquise au CHU de Liège. Nous voulons également revoir les indications potentielles de cette radiothé - rapie de très haute précision [less ▲]

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See detailIndirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women.
Ellis, Alexandra G.; Reginster, Jean-Yves ULg; Luo, Xuemei et al

in Current medical research and opinion (2014), 30(8), 1617-1626

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on ... [more ▼]

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on evidence from randomized controlled trials (RCTs). Methods: Eight RCTs assessing vertebral fracture risk reduction with oral bisphosphonates (n = 7) or bazedoxifene (n = 1) were identified by a systematic literature review. Individual study results were pooled in a network meta-analysis (NMA) to indirectly compare treatment effects for overall PMO women and a higher-risk subgroup (FRAX >/= 20%). Three sets of NMA analyses were conducted: aggregate data (AD) from the bisphosphonate RCTs and bazedoxifene RCT for the full population or the FRAX >/=20% subgroup (NMA AD); bisphosphonate AD and bazedoxifene AD from each FRAX subgroup adjusted for baseline risk (NMA AD meta-regression); and bisphosphonate AD and bazedoxifene individual patient data (IPD) adjusted for baseline risk/FRAX (NMA AD/IPD meta-regression). Results: For the overall population, bisphosphonates had lower fracture risks versus bazedoxifene although there is considerable uncertainty in supporting one intervention over another. The relative risk reduction (RRR) for bazedoxifene was -0.23 (95% CrI: -1.11, 0.27) versus ibandronate, -0.17 (-0.76, 0.22) versus alendronate, and -0.06 (-0.62, 0.30) versus risedronate. Results from the meta-regression analyses were similar. For the FRAX >/=20% population, estimated fracture rates with bazedoxifene were lower than with bisphosphonates, but again the uncertainty limits strong interpretation. The RRR for bazedoxifene was 0.51 (-0.31, 0.83) versus ibandronate, 0.53 (-0.18, 0.83) versus alendronate, and 0.57 (-0.07, 0.85) versus risedronate. The meta-regression analyses showed comparable findings. Conclusion: The analyses only considered vertebral fractures for oral bisphosphonates versus bazedoxifene, and IPD was available only for bazedoxifene. In light of this, bazedoxifene is comparable to bisphosphonates in the overall PMO population and at least as effective as bisphosphonates for preventing vertebral fractures among higher-risk PMO patients. The findings suggest bazedoxifene performs better in higher-risk PMO than in the overall PMO. [less ▲]

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See detailL’intérêt de la spectroscopie proche infrarouge en analyse de terre (synthèse bibliographique)
Genot, Valérie ULg; Bock, Laurent ULg; Dardenne, Pierre et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2),

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See detailAtlantic-Pacific seesaw and its role in outgassing CO2 during Heinrich events
Menviel, L.; England, M.H.; Meissner, K.J. et al

in Paleoceanography (2014), 29

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See detailL’éjaculation précoce : une revue de questions
Kempeneers, Philippe ULg; ANDRIANNE, Robert ULg; Lequeux, Armand et al

in Revue Francophone de Clinique Comportementale et Cognitive (2014), 19(2), 35-60

Premature ejaculation (PE) is a disorder characterized by three components: (1) a rapid ejaculation, (2), a feeling of lack of control upon ejaculation, (3) and a distress related to this condition. The ... [more ▼]

Premature ejaculation (PE) is a disorder characterized by three components: (1) a rapid ejaculation, (2), a feeling of lack of control upon ejaculation, (3) and a distress related to this condition. The criterion of rapidity appears to be most controversial: some authors refer only to subjects’ judgment, while other ones set a maximum ejaculatory latency. Although it focused some criticisms related to a lack of objective latency criteria, the definition of PE propounded by the DSM-IV(-TR) remains most currently used. PE affects about 15 to 30% of the male population. However, the estimations can vary widely depending on populations and methodologies. Several factors contribute to the occurrence of the disorder: one may very probably charge bio-constitutional risks, learning factors, cultural and cognitive influences and the role of anxiety. No robust data allow to implicate personality factors other than anxiety. The influence of the age remains a controversial topic. Cognitive-behavioral techniques appear to be quite efficient in the treatment of PE. However the success rates are variable, and the precise nature of the therapeutic active process remains unclear. Serotonergic drugs and local anesthetics are also efficient, but their action remains strictly symptomatic. The usefulness of phosphodiesterase-5 inhibitors is disputed. Combining psychological and pharmacological approaches might be promising. Unfortunately, there is a lack of clinical trials in this field. Although effective treatments do exist, only a few affected people appear to use them satisfactorily. Efforts have still to be made in order to train adequately heath practitioners and to make the treatments more accessible to the public. [less ▲]

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See detailWhat is a Postcolonial Comic?
Dony, Christophe ULg

in Mixed Zone: Chronique de Littérature Internationale (2014), 7

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See detailEFSA's scientific activities and achievements on the risk assessment of genetically modified organisms (GMOs) during its first decade of existence: looking back and ahead.
Devos, Yann; Aguilera, Jaime; Diveki, Zoltan et al

in Transgenic research (2014), 23(1), 1-25

Genetically modified organisms (GMOs) and derived food and feed products are subject to a risk analysis and regulatory approval before they can enter the market in the European Union (EU). In this risk ... [more ▼]

Genetically modified organisms (GMOs) and derived food and feed products are subject to a risk analysis and regulatory approval before they can enter the market in the European Union (EU). In this risk analysis process, the role of the European Food Safety Authority (EFSA), which was created in 2002 in response to multiple food crises, is to independently assess and provide scientific advice to risk managers on any possible risks that the use of GMOs may pose to human and animal health and the environment. EFSA's scientific advice is elaborated by its GMO Panel with the scientific support of several working groups and EFSA's GMO Unit. This review presents EFSA's scientific activities and highlights its achievements on the risk assessment of GMOs for the first 10 years of its existence. Since 2002, EFSA has issued 69 scientific opinions on genetically modified (GM) plant market registration applications, of which 62 for import and processing for food and feed uses, six for cultivation and one for the use of pollen (as or in food), and 19 scientific opinions on applications for marketing products made with GM microorganisms. Several guidelines for the risk assessment of GM plants, GM microorganisms and GM animals, as well as on specific issues such as post-market environmental monitoring (PMEM) were elaborated. EFSA also provided scientific advice upon request of the European Commission on safeguard clause and emergency measures invoked by EU Member States, annual PMEM reports, the potential risks of new biotechnology-based plant breeding techniques, evaluations of previously assessed GMOs in the light of new scientific publications, and the use of antibiotic resistance marker genes in GM plants. Future challenges relevant to the risk assessment of GMOs are discussed. EFSA's risk assessments of GMO applications ensure that data are analysed and presented in a way that facilitates scientifically sound decisions that protect human and animal health and the environment. [less ▲]

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See detailFatal transmission of contagious caprine pleuropneumonia to an Arabian oryx (Oryx leucoryx)
Chaber, AL; Lignereux, L; Al Qassimi, M et al

in Veterinary Microbiology (2014), 173(1-2), 156-159

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See detailAntioxidant Activity of Compounds Isolated from the Root Woods of Erythrina droogmansiana
Yaya, AJG; Feumba, RD; Emmanuel, T et al

in International Journal of Pharmaceutical Sciences and Drug Research (2014), 6(2), 160-163

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract ... [more ▼]

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract and isolated compounds. The phytochemical study led to the isolation of 3-(3’,4’-methelenedioxyphenyl)-2,3-epoxypropanol (1), asperphenamate (2) and three flavonoids namely genistein, diadzein and 4’,5,7-trihydroxy-8-prenylisoflavone. These compounds were characterized using their 1H NMR, 13C NMR, HMBC, HSQC, COSY, mass spectral and the literature. To evaluate antioxidant activity of crude extract and isolated compounds, the radical scavenging (DPPH) and Ferric Reducing Ability Power (FRAP) were performed using ascorbic acid as standard. Compounds 1 and 2 showed moderate radical scavenging potential with IC50 value of 3.14 and 3.31 mg/ml respectively, and moderate reducing power ability with value of 0.14±0.01 mgAAE/mg and 0.21±0.01 mgAAE/mg respectively. The more active compound was genistein (3) with IC50 value of 1.96 mg/ml for the DPPH radical scavenging potential and 0.24±0.02 mgAAE/mg for its ability to reduce iron. [less ▲]

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See detailSurgical treatment of bicuspid aortic valve disease: Knowledge gaps and research perspectives.
Della Corte, Alessandro; Body, Simon C.; Booher, Anna M. et al

in The Journal of thoracic and cardiovascular surgery (2014)

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See detailA one phase thermomechanical model for the numerical simulation of semi-solid material behavior. Application to thixoforming
Koeune, Roxane; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2014), 58

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called ... [more ▼]

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called thixotropy that can be displayed by some metallic alloys heated up to their semi-solid state. It is a particular evolutionary behavior which is characterized by a solidlike behavior at rest and a liquid flow during shearing, thus by a decrease of the viscosity and of the resistance to deformation while sheared. An original one-phase thermo-elasto-viscoplastic constitutive model has been developed. The basic idea is to extend the classical isotropic hardening and viscosity models beyond the solid state by considering two more non-dimensional internal scalar parameters. The semi-solid state is treated as a particular case, and one of the main features of the proposed constitutive model is that it remains valid over a wide range of temperatures, starting from room temperature to above the liquidus in a continuous manner, thus allowing a continuous transition between classical solid and fluid behavior. Another feature is that, after the forming step, it is possible to simulate the cooling down of the component back to room temperature using the elastic–viscoplastic model. So it is possible to estimate residual stresses, something that is definitely impossible while using a fluid-like model or a rigid viscoplastic approach. The presented model is illustrated and validated by means of representative numerical applications, as two different extrusion tests are carried out and the computed predictions are compared to experimental results. [less ▲]

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See detailPractice of enteral nutrition in very low birth weight and extremely low birth weight infants
SENTERRE, Thibault ULg

in World Review of Nutrition and Dietetics (2014), 110

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See detailBone marrow stromal stem cells transplantation in mice with acute spinal cord injury
Neirinckx, Virginie ULg; Rogister, Bernard ULg; Franzen, Rachelle ULg et al

in Methods in Molecular Biology (Clifton, N.J.) (2014), 1213

Spinal cord injured experimental animals are widely used for studying pathophysiological processes after central nervous system acute traumatic lesion and elaborating therapeutic solutions, some of them ... [more ▼]

Spinal cord injured experimental animals are widely used for studying pathophysiological processes after central nervous system acute traumatic lesion and elaborating therapeutic solutions, some of them based on stem cell transplantation. Here, we describe a protocol of spinal cord contusion in C57BL/6J mice, directly followed by bone marrow stromal stem cells transplantation. This model allows for the characterization of neuroprotective and neurorestorative abilities of these stem cells in a context of spinal cord trauma. [less ▲]

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See detailLongitudinal assessment of progress in reasoning capacity and relation with self-estimation of knowledge base
Collard, Anne ULg; Mélot, France ULg; Bourguignon, Jean-Pierre ULg

in Assessment & Evaluation in Higher Education (2014)

The aim of the study was to investigate progress in reasoning capacity and knowledge base appraisal in a longitudinal analysis of data from summative evaluation throughout a medical problem-based learning ... [more ▼]

The aim of the study was to investigate progress in reasoning capacity and knowledge base appraisal in a longitudinal analysis of data from summative evaluation throughout a medical problem-based learning curriculum. The scores in multidisciplinary discussion of a clinical case and multiple choice questionnaires (MCQs) were studied longitudinally for 213 students from years 2 to 5. The capacity of core knowledge delimitation was calculated as the difference between the levels of average ascertainment degrees given for correct and incorrect answers at MCQ. For both multidisciplinary discussion of a clinical case evaluation and self-estimation of core knowledge, the capacity increases throughout the curriculum. The reasoning capacity assessed through multidisciplinary discussion of a clinical case is positively correlated with MCQ scores and the capacity to discriminate the mastered core knowledge. In conclusion, this study indicates that self-estimation of core knowledge is associated with an increase in reasoning performance through a well-organised knowledge base. Since that ability is related to success or failure, it is suggested that student awareness about delimitation of mastered core knowledge is considered as part of learning. [less ▲]

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See detailAphid honeydew: An arrestant and a contact kairomone for Episyrphus balteatus (Diptera: Syrphidae) larvae and adults
Leroy, Pascal; Almohamad, Raki; Attia, Sabrine et al

in European Journal of Entomology (2014), 111(2), 237-242

Predator searching efficiency increases in response to a variety of environmental cues associated with its prey. The sugary excretion of aphids (honeydew) has been found to act as a prey-associated cue ... [more ▼]

Predator searching efficiency increases in response to a variety of environmental cues associated with its prey. The sugary excretion of aphids (honeydew) has been found to act as a prey-associated cue for many aphid natural enemies. In the present study, the honeydew excreted by Acyrthosiphon pisum (Harris) was identified as an arrestant and a contact kairomone for young larvae and adults of a common predatory hoverfly, Episyrphus balteatus (De Geer) (Diptera: Syrphidae). First and second instar larvae increased their foraging behaviour in the honeydew-treated area. When plants were sprayed with crude honeydew, the speed of movement of female E. balteatus was significantly higher than in controls, resulting in a longer period of time spent on treated plants and laying eggs. We conclude that the honeydew excreted by A. pisum induces searching behaviour and acts as and arrestant not only for adults but also for young E. balteatus larvae. [less ▲]

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See detailNitroxide mediated polymerization of methacrylates at moderate temperature
Detrembleur, Christophe ULg; Jérôme, Christine ULg; De Winter, Julien et al

in Polymer Chemistry (2014), 5(2), 335-340

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide ... [more ▼]

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide precursor. The combination of a low temperature azo-initiator with a hindered nitroso-compound produces a mixture of hindered nitroxides in the polymerization medium that act as efficient polymerization control agents. Results of Electron Spin Resonance (ESR) spectroscopy experiments combined with mass spectrometric studies support the proposed in situ NMP mechanism. The hindered structure of the nitroxides formed in situ is believed to be responsible for the efficiency of the process by allowing it to proceed at low temperature, therefore limiting the side reactions generally observed in NMP of methacrylates. [less ▲]

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See detailOleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig.
Horcajada, M.-N.; Sanchez, Christelle ULg; Membrez Scalfo et al

in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society (2014)

OBJECTIVE: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, on joint ageing and osteoarthritis (OA) development. DESIGN: Sixty 4-week-old Dunkin-Hartley ... [more ▼]

OBJECTIVE: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, on joint ageing and osteoarthritis (OA) development. DESIGN: Sixty 4-week-old Dunkin-Hartley guinea pigs were randomized into four groups and received daily during 31 weeks either standard guinea pig diet (control group) or a standard guinea pig diet enriched with oleuropein (0.025%), rutin (0.5%) or rutin/curcumin (0.5%/0.25%) association. Biomarkers of OA (Coll2-1, Coll2-1NO2, Fib3-1, Fib3-2, ARGS), as well as inflammation (PGE2) were quantified in the serum. Histological assessments of knee cartilage and synovial membrane were performed at week 4 (five young reference guinea pigs) and week 35. RESULTS: At week 35, guinea pigs in the control group spontaneously developed significant cartilage lesions with mild synovial inflammation. The histological scores of cartilage lesions and synovitis were well correlated with the increased level of serum biomarkers. Histologically, all treatments significantly reduced the cartilage degradation score (P < 0.01), but only oleuropein significantly decreased the synovial histological score (P < 0.05) and serum PGE2 levels (P < 0.01) compared to the control group. Coll2-1 was decreased by rutin and the combination of rutin/curcumin, Fib3-1 and Fib3-2 were only decreased by the rutin/curcumin mixture, while Coll2-1NO2 was significantly decreased by all treatments (P < 0.05). CONCLUSION: Oleuropein and rutin +/- curcumin significantly slowed down the progression of spontaneous OA lesions in guinea pigs. While no additive effect was seen in the curcumin + rutin group, the differential effects of oleuropein and rutin on inflammatory and cartilage catabolic markers suggest an interesting combination for future studies in OA protection. [less ▲]

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See detailLéopold Auguste Warnkönig et François Laurent Pionniers des Universités de Liège et Gand
Gerkens, Jean-François ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), (1), 157-171

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See detailImpact of purification and fractionation process on the chemical structure and physical properties of locust bean gum
Gillet, Sébastien ULg; Blecker, Christophe ULg; Aguedo, Mario ULg et al

in Carbohydrate Polymers (2014)

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on ... [more ▼]

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on the residual impoverished fraction (GM80). The complete structural characterization has shown that GM80 possessed relatively longer chain lengths than GM25, a slightly lower degree of galactose substitution and a somewhat sharper galactosyl distribution in substituted and unsubstituted regions. A physical behavior analysis was carried out on solubilization kinetics, viscosity, viscoelasticity and formation of associated gels with xanthan or carrageenan. The average structure of GM80 generated larger intra-chain, inter-chain and inter-molecular interactions, resulting in the appearance of a stronger network. Small structural differences therefore generated very different physical behaviors. This study thus allowed to establish, in a precise and complete manner, fractionation-purification-structure-function relationships of galactomannans extracted from carob. [less ▲]

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See detailSarapis et Neôtera élus parmi les dieux
Veymiers, Richard ULg

in Revue Archéologique (2014), (1), 37-56

One of the bronze plates formerly in the Bianchini collection, which entered the Cabinet des Médailles (Paris) at the end of the 18th century, bears a text and an image, supposedly unintelligible and ... [more ▼]

One of the bronze plates formerly in the Bianchini collection, which entered the Cabinet des Médailles (Paris) at the end of the 18th century, bears a text and an image, supposedly unintelligible and therefore thought to be of a magic nature. A new examination of this artefact, actually the main part of a bracelet, shows that it depicts an assembly of twenty-eight divinities, illustrating the religious landscape of Egypt in the 2nd-3rd century, and that it is inscribed with two short acclamations. The first one exalts the greatness of the name of Sarapis, the second that of Neôtera the invincible. The identity of this goddess is difficult to define, but she often seems to correspond to a form of Isis assimilated to Korè. The glorifying invocation of these two gods, depicted with their pantheon, may be considered to be an expression of what is today called “megatheism”. [less ▲]

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See detailSeasonal and depth-related biodiversity of leaf epiphytic Cheilostome Bryozoa in a Mediterranean Posidonia oceanica meadow
Lepoint, Gilles ULg; Balancier, Boris; Gobert, Sylvie ULg

in Cahiers de Biologie Marine (2014), 55(1),

: Epiphytes living fixed on Posidonia oceanica L. (Delile) are important faunal and floral components of seagrass meadow ecosystems. They are involved as main actors in trophic web and major ecosystem ... [more ▼]

: Epiphytes living fixed on Posidonia oceanica L. (Delile) are important faunal and floral components of seagrass meadow ecosystems. They are involved as main actors in trophic web and major ecosystem processes of this endangered coastal habitat. This paper aims to assess the seasonality and the bathymetric variability of epiphytic Bryozoa which are the most important animal group in terms of both diversity and abundance living on P. oceanica leaves. Posidonia shoots were collected from the Revellata Bay (Corsica, France) in four seasons from 7 to 30 m depth. Colony densities reached more than 87000 colonies. m-2 at 10 m depth in spring. The bryozoan species distribution and abundance changed substantially according to seasons and depths, being maximum in spring and minimal in winter. Dominant colony morphotypes change according to depth, probably in relation with water motion gradient. This confirms that there are bathymetric and seasonal variability for different epiphytic organisms colonizing the Posidonia leaves. This enlightens the importance to protect Posidonia meadow on its full depth extension and in its connectivity with other habitats to conserve optimal epiphytic biodiversity and functions. [less ▲]

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See detailCould the chemical contamination be the cause of the increase in the number of stranded harbour porpoises (Phocoena phocoena) along the Southern North Sea?
Mahfouz, C.; Henry, F.; Pezeril, S. et al

in Environmental Research (2014)

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See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging: Part II.
Plein, Sven; Edvardsen, Thor; Pierard, Luc ULg et al

in European heart journal cardiovascular Imaging (2014)

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in ... [more ▼]

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in two articles. Part I of the review has summarized studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging. Part II is focussed on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

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See detailTissue Proteomics for the Next Decade? Towards a Molecular Dimension in Histology
Longuespée, Rémi ULg; Fléron, Maximilien; Pottier, Charles et al

in OMICS : A Journal of Integrative Biology (2014)

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See detailMesophilic biohydrogen production by Clostridium butyricum CWBI1009 in trickling biofilter reactor
Puhulwella, Rathnasiri G.; Beckers, Laurent; Delvigne, Frank ULg et al

in International Journal of Hydrogen Energy (2014), (0),

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See detailUpfront allogeneic stem cell transplantation after reduced-intensity/nonmyeloablative conditioning for patients with myelodysplastic syndrome : a study by the Société Française de Greffe de Moelle et de Thérapie Cellulaire
Damaj, Gandhi; Mohty, Mohammad; Robin, Marie et al

in Biology of Blood & Marrow Transplantation (2014), 20

Cytoreduction before allogeneic stem cell transplantation (allo-SCT) for patients with myelodysplastic syndromes remains a debatable issue. After excluding patients who had received preconditioning ... [more ▼]

Cytoreduction before allogeneic stem cell transplantation (allo-SCT) for patients with myelodysplastic syndromes remains a debatable issue. After excluding patients who had received preconditioning induction chemotherapy, we analyzed 128 consecutive patients with myelodysplastic syndrome who received reducedintensity or nonmyeloablative conditioning (RIC/NMA) allo-SCT. Among them, 40 received azacitidine (AZA) before transplant (AZA group) and 88 were transplanted up front (best supportive care [BSC] group). At diagnosis, 55 patients had intermediate 2 or high-risk scores per the International Prognostic Scoring System and 33 had a high cytogenetic risk score. Progression to a more advanced disease before allo-SCT was recorded in 22 patients. Source of stem cells were blood (n ¼ 112) or marrow (n ¼ 16) from sibling (n ¼ 78) or HLA-matched unrelated (n ¼ 50) donors. With a median follow-up of 60 months, 3-year overall survival, relapse-free survival, cumulative incidence of relapse, and nonrelapse mortality were, respectively, 53% versus 53% (P ¼ .69), 37% versus 42% (P ¼ .78), 35% versus 36% (P ¼ .99), and 20% versus 23% (P ¼ .74), for the AZA group and BSC group, respectively. Multivariate analysis confirmed the absence of statistical differences in outcome between the AZA and BSC groups, after adjusting for potential confounders using the propensity score approach. The absence of cytoreduction before RIC/NMA allo-SCT did not seem to alter the outcome. However, our results emphasize the need to perform prospective protocols to delineate the role of debulking strategy and to identify subsets of patients who may benefit from this approach. [less ▲]

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See detailStimulant and motivational effects of alcohol: Lessons from rodent and primate models
Brabant, Christian ULg; Guarnieri, Douglas J.; Quertemont, Etienne ULg

in Pharmacology, Biochemistry & Behavior (2014), 122

In several animal species including humans, the acute administration of low doses of alcohol increasesmotor activity. Different theories have postulated that alcohol-induced hyperactivity is causally ... [more ▼]

In several animal species including humans, the acute administration of low doses of alcohol increasesmotor activity. Different theories have postulated that alcohol-induced hyperactivity is causally related to alcoholism.Moreover, a common biological mechanism in the mesolimbic dopamine system has been proposed to mediate the stimulant and motivational effects of alcohol. Numerous studies have examined whether alcohol-induced hyperactivity is related to alcoholism using a great variety of animal models and several animal species. However, there is no review that has summarized this extensive literature. In this article, we present the various experimental models that have been used to study the relationship between the stimulant and motivational effects of alcohol in rodents and primates. Furthermore, we discuss whether the theories hypothesizing a causal link between alcohol-induced hyperactivity and alcoholism are supported by published results. The reviewed findings indicate that animal species that are stimulated by alcohol also exhibit alcohol preference. Additionally, the role of dopamine in alcohol-induced hyperactivity is well established since blocking dopaminergic activity suppresses the stimulant effects of alcohol. However, dopamine transmission plays a much more complex function in the motivational properties of alcohol and the neuronal mechanisms involved in alcohol stimulation and reward are distinct. Overall, the current review provides mixed support for theories suggesting that the stimulant effects of alcohol are related to alcoholism and highlights the importance of animal models as a way to gain insight into alcoholism. [less ▲]

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See detailLes niveaux d'analyse dans la microstructure de l'Atlas linguistique de la Wallonie
Baiwir, Esther ULg

in Estudis Romànics (2014), 36

Le lecteur de l'ALW constate rapidement que les formes phonétiques n'y sont pas livrées brutes sur des cartes, comme dans les atlas de France par région, ni sous forme de liste, mais bien dans une ... [more ▼]

Le lecteur de l'ALW constate rapidement que les formes phonétiques n'y sont pas livrées brutes sur des cartes, comme dans les atlas de France par région, ni sous forme de liste, mais bien dans une présentation structurée en paragraphes, regroupant selon des critères variables des formes phonétiques distinctes. Après avoir proposé une schématisation de la microstructure du projet, sur base d'une notice-modèle (1), nous détaillerons ces critères de classement (phonologique, morphologique, syntaxique, étymologique, motivationnel ou encore sémantique; 2). Chaque paragraphe de matériaux porte un titre, qui représente d'une façon plus ou moins abstraite les matériaux qu'il comporte. Ce titre peut prendre différentes formes: une orthographe dite « Feller » ou des types reconstruits plus abstraits. Nous tenterons de montrer en quoi ces deux images très différentes des matériaux ne sont pas réductibles l'une à l'autre (3). [less ▲]

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See detailBrominated and phosphorus flame retardants in White-tailed Eagle Haliaeetus albicilla nestlings: Bioaccumulation and associations with dietary proxies (δ13C, δ15N and δ34S)
Eulaers, Igor; Jaspers, Veerle; Halley, Duncan et al

in Science of the Total Environment (2014), 478

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation ... [more ▼]

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation potential, and toxicity have been made. We investigated the accumulation of BFRs and PFRs, and their associations with dietary proxies (δ13C, δ15N and δ34S), in plasma and feathers of White-tailed Eagle Haliaeetus albicilla nestlings from Trøndelag, Norway. In addition to accumulation of a wide range of polybrominated diphenyl ether (PBDE) congeners in both plasma and feathers, all non-PBDE BFRs and PFRs could be measured in feathers, while in plasma only two of six PFRs, i.e. tris-(2-chloroisopropyl) phosphate (TCIPP) and tris-(2,3-dichloropropyl) phosphate (TDCPP) were detected. PFR concentrations in feathers (0.95-3,000 ng g-1) were much higher than selected organochlorines (OCs), such as polychlorinated biphenyl 153 (CB 153; 2.3-15 ng g-1) and dichlorodiphenyldichloroethylene (p,p’-DDE; 2.3-21 ng g-1), PBDEs (0.03-2.3 ng g-1) and non-PBDE BFRs (0.03-1.5 ng g-1). Non-significant associations of PFR concentrations in feathers with those in plasma (P≥0.74), and their similarity to reported atmospheric PFR concentrations, may suggest atmospheric PFR deposition on feathers. Most OCs and PBDEs, as well as tris(chloroethyl) phosphate (TCEP), tris(phenyl) phosphate (TPHP) and tri-(2-butoxyethyl) phosphate (TBOEP) were associated to δ15N and/or δ13C (all P≤0.02). Besides δ15N enrichment, δ34S was depleted in nestlings from fjords, inherently close to an urbanised centre. As such, both may have been a spatial proxy for anthropogenic disturbance, possible confounding their use as dietary proxy. [less ▲]

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See detailLa présence isiaque dans le Péloponnèse. Sur les traces des lieux de culte
Veymiers, Richard ULg

in Revue archéologique. Bulletin de la Société française d'archéologie classique (SFAC). (2014), 1

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See detailSurgery for severe ischemic mitral regurgitation.
Magne, Julien; Pierard, Luc ULg

in The New England journal of medicine (2014), 370(15), 1462

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See detailA New Look at Ichthyosaur Long Bone Microanatomy and Histology: Implications for Their Adaptation to an Aquatic Life
Houssaye, Alexandra; Scheyer, Torsten; Kolb, Christian et al

in PLoS ONE (2014), 9(4), 95637

Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades ... [more ▼]

Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades. Data concerning their bone microanatomical and histological features are rather limited and suggest that ichthyosaurs display a spongious, “osteoporotic-like” bone inner structure, like extant cetaceans. However, some taxa exhibit peculiar features, suggesting that the analysis of the microanatomical and histological characteristics of various ichthyosaur long bones should match the anatomical diversity and provide information about their diverse locomotor abilities and physiology. Methodology/Principal Findings The material analyzed for this study essentially consists of mid-diaphyseal transverse sections from stylopod bones of various ichthyosaurs and of a few microtomographic (both conventional and synchrotron) data. The present contribution discusses the histological and microanatomical variation observed within ichthyosaurs and the peculiarities of some taxa (Mixosaurus, Pessopteryx). Four microanatomical types are described. If Mixosaurus sections differ from those of the other taxa analyzed, the other microanatomical types, characterized by the relative proportion of compact and loose spongiosa of periosteal and endochondral origin respectively, seem to rather especially illustrate variation along the diaphysis in taxa with similar microanatomical features. Our analysis also reveals that primary bone in all the ichthyosaur taxa sampled (to the possible exception of Mixosaurus) is spongy in origin, that cyclical growth is a common pattern among ichthyosaurs, and confirms the previous assumptions of high growth rates in ichthyosaurs. Conclusions/Significance The occurrence of two types of remodelling patterns along the diaphysis, characterized by bone mass decrease and increase respectively is described for the first time. It raises questions about the definition of the osseous microanatomical specializations bone mass increase and osteoporosis, notably based on the processes involved, and reveals the difficulty in determining the true occurrence of these osseous specializations in ichthyosaurs. [less ▲]

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See detailHigh-energy X-ray tomography analysis of a metal packing biofilm reactor for the production of lipopeptides by Bacillus subtilis
Zune, Quentin ULg; Soyeurt, Delphine; Toye, Dominique ULg et al

in Journal of Chemical Technology & Biotechnology (2014), 89

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the ... [more ▼]

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the production of high-value metabolites. Technically, this new concept relies on the design of bioreactors able to promote biofilm formation and on the identification of the key physico-chemical parameters involved in biofilm formation. RESULTS: An experimental setting comprising a liquid continuously recirculated on a metal structured packing has been used to promote Bacillus subtilis GA1 biofilm formation. The colonization of the packing has been visualized non-invasively by X-ray tomography. This analysis revealed an uneven, conical, distribution of the biofilm inside the packing. Compared with a submerged culture carried out in a stirred tank reactor, significant modification of the lipopeptide profile has been observed in the biofilm reactorwith the disappearance of fengycin and iturin fractions and an increase of the surfactin fraction. In addition, considering the biofilm reactor design, no foam formation has been observed during the culture. CONCLUSIONS: The configuration of this biofilm reactor set-up allows for a higher surfactin production by comparison with a submerged culture while avoiding foam formation. Additionally, scale-up could easily be performed by increasing the number of packing elements. [less ▲]

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See detailInventaire préliminaire des termites (Isoptera) du plateau des Batékés en République Démocratique du Congo
Kifukieto, Carmel; Deligne, Jean; Kachaka, Claude et al

in Entomologie Faunistique = Faunistic Entomology (2014), 67

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See detailPersonalising metformin therapy: a clinician's perspective
SCHEEN, André ULg

in Lancet Diabetes & Endocrinology (2014)

If lifestyle changes are not effective for maintaining glycaemic control, metformin is recommended as the first glucose-lowering drug to use in a patient with type 2 diabetes, if the patient has no ... [more ▼]

If lifestyle changes are not effective for maintaining glycaemic control, metformin is recommended as the first glucose-lowering drug to use in a patient with type 2 diabetes, if the patient has no contraindications—eg, renal impairment or hypoxic disorders.1 However, the glucose-lowering response to metformin can vary greatly between patients, with some people responding poorly to this biguanide. Because of the well known therapeutic inertia with respect to pharmacological treatment of diabetes, insufficient glucose control might persist for a long time before any treatment adjustment is made in people who respond poorly to metformin monotherapy. [less ▲]

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See detailHypothalamic response to the chemo-signal androstadienone in gender dysphoric children and adolescents.
Burke, Sarah M.; Cohen-Kettenis, Peggy T.; Veltman, Dick J. et al

in Frontiers in endocrinology (2014), 5

The odorous steroid androstadienone, a putative male chemo-signal, was previously reported to evoke sex differences in hypothalamic activation in adult heterosexual men and women. In order to investigate ... [more ▼]

The odorous steroid androstadienone, a putative male chemo-signal, was previously reported to evoke sex differences in hypothalamic activation in adult heterosexual men and women. In order to investigate whether puberty modulated this sex difference in response to androstadienone, we measured the hypothalamic responsiveness to this chemo-signal in 39 pre-pubertal and 41 adolescent boys and girls by means of functional magnetic resonance imaging. We then investigated whether 36 pre-pubertal children and 38 adolescents diagnosed with gender dysphoria (GD; DSM-5) exhibited sex-atypical (in accordance with their experienced gender), rather than sex-typical (in accordance with their natal sex) hypothalamic activations during olfactory stimulation with androstadienone. We found that the sex difference in responsiveness to androstadienone was already present in pre-pubertal control children and thus likely developed during early perinatal development instead of during sexual maturation. Adolescent girls and boys with GD both responded remarkably like their experienced gender, thus sex-atypical. In contrast, pre-pubertal girls with GD showed neither a typically male nor female hypothalamic activation pattern and pre-pubertal boys with GD had hypothalamic activations in response to androstadienone that were similar to control boys, thus sex-typical. We present here a unique data set of boys and girls diagnosed with GD at two different developmental stages, showing that these children possess certain sex-atypical functional brain characteristics and may have undergone atypical sexual differentiation of the brain. [less ▲]

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See detailGalectin Expression Profiling Identifies Galectin-1 and Galectin-9Δ5 as Prognostic Factors in Stage I/II Non-Small Cell Lung Cancer
Schulkens, Iris; Heusschen, Roy ULg; Van den boogaart, Vivianne et al

in PLoS ONE (2014)

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See detailChoisir des cas exemplaires. La Strategic litigation face aux discriminations
Lejeune, Aude ULg; Orianne, Jean-François ULg

in Déviance et Société (2014), 38(1), 55-76

Strategic litigation is one of the methods used by equal opportunity agencies in Europe to promote rights. Looking at the organizational level, this article aims to show how and under which circumstances ... [more ▼]

Strategic litigation is one of the methods used by equal opportunity agencies in Europe to promote rights. Looking at the organizational level, this article aims to show how and under which circumstances strategic litigation is deemed relevant to fight employment discrimination in Belgium and on which grounds and arguments exemplary cases are chosen. The article also highlights possible changes in the mobilizations of courts and the judicial arena. [less ▲]

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See detailActeurs, ressources et réseaux sociologiques d'échanges à partir de l'expérience belge
Vrancken, Didier ULg

in Sociologies Pratiques (2014)

Plutôt que de procéder à un bilan de la sociologie en Belgique francophone, l'auteur opte pour une présentation de cette dernière à partir de quelques travaux qui se sont attelés à décrypter les ... [more ▼]

Plutôt que de procéder à un bilan de la sociologie en Belgique francophone, l'auteur opte pour une présentation de cette dernière à partir de quelques travaux qui se sont attelés à décrypter les arrangements, les compromis, les accords au sein d'un pays continuellement confronté à ces mêmes questions. [less ▲]

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See detailCusp observation at Saturn’s high-latitude magnetosphere by the Cassini spacecraft
Jasinski; Arridge; Lamy et al

in Geophysical Research Letters (2014)

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See detailLe renoncement au désir de maternité comme issue possible d’une conflictualité intrapsychique
Delli Gatti, Tamara ULg; Naziri, Despina ULg

in Dialogue : Recherches Cliniques et Sociologiques sur le Couple et la Famille (2014), 204

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See detailEvidence for an own-age bias in age estimation from voices in older persons
Moyse, Evelyne ULg; Beaufort, Aline ULg; Brédart, Serge ULg

in European Journal of Ageing (2014)

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the ... [more ▼]

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the occurrence of an own age effect on age estimation from voices has never been examined earlier using an experimental design in which the age of participants (young vs. old) and the age of voice stimuli (young vs. old) were crossed. Results revealed an own-age bias in older adults only. In comparison with younger adults, older participants showed age estimation abilities that are preserved for voices from their own age group and impaired for younger voices. This own age bias was absent in younger participants. [less ▲]

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See detailEmotional Facial Expression Recognition and Expressivity in Type I and Type II Alcohol Dependent Patients
Dethier, Marie ULg; El Hawa, Maya; Duchateau et al

in Journal of Nonverbal Behavior (2014), 38(1), 89-105

Objective: Alcohol dependent patients (ADs) are known to encounter severe interpersonal problems. Nonverbal communication skills are important for the development of healthy relationships. The present ... [more ▼]

Objective: Alcohol dependent patients (ADs) are known to encounter severe interpersonal problems. Nonverbal communication skills are important for the development of healthy relationships. The present study aimed to explore emotional facial expression (EFE) recognition and posed and spontaneous EFE expressivity in male ADs divided into two groups according to Cloninger’s typology and the impact of their interpersonal relationship quality on the potential nonverbal deficits. Method: Twenty type I ADs, twenty-one type II ADs, and twenty control participants took part in an EFE recognition task and an EFE expressivity task that considered personal emotional events (spontaneous expressivity) and EFE in response to a photo or word cue (posed expressivity). Coding was based on judges’ ratings of participants’ emotional facial expressions. Participants additionally completed a questionnaire on interpersonal relationship quality. Results: No difference between the three groups emerged in the EFE recognition task. Type II ADs showed heightened deficits compared with type I ADs in EFE expressivity: Judges perceived less accurate posed EFE in response to a cue word and less intense and positive spontaneous EFE in type II ADs compared to control participants. In addition, type II ADs reported more relationship difficulties compared to both type I ADs and control participants. These interpersonal relationship difficulties were related to some of the EFE expressivity deficits of AD-IIs. Conclusions: This study underlines the important differences between the interpersonal functioning of AD subtypes. [less ▲]

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See detailA ring system detected around the Centaur (10199) Chariklo
Braga-Ribas; Sicardy; Ortiz et al

in Nature (2014)

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See detailThe uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor alpha modulation, uncoupling nuclear and membrane activation.
Abot, Anne; Fontaine, Coralie; Buscato, Melissa et al

in EMBO molecular medicine (2014), 6(10), 1328-46

Estetrol (E4) is a natural estrogen with a long half-life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor alpha (ERalpha) ligand-binding domain ... [more ▼]

Estetrol (E4) is a natural estrogen with a long half-life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor alpha (ERalpha) ligand-binding domain bound to 17beta-estradiol (E2) and E4 are very similar, as well as their capacity to activate the two activation functions AF-1 and AF-2 and to recruit the coactivator SRC3. In vivo administration of high doses of E4 stimulated uterine gene expression, epithelial proliferation, and prevented atheroma, three recognized nuclear ERalpha actions. However, E4 failed to promote endothelial NO synthase activation and acceleration of endothelial healing, two processes clearly dependent on membrane-initiated steroid signaling (MISS). Furthermore, E4 antagonized E2 MISS-dependent effects in endothelium but also in MCF-7 breast cancer cell line. This profile of ERalpha activation by E4, uncoupling nuclear and membrane activation, characterizes E4 as a selective ER modulator which could have medical applications that should now be considered further. [less ▲]

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See detailMarcos, la botarga. ¿Avatar o despedida del Subcomandante?
Vanden Berghe, Kristine ULg

in Asociación para el Fomento de los Estudios Históricos en Centroamérica (2014), 60

Se evalúa hasta qué punto la despedida del Sucomandante Marcos en mayo de 2014 se inscribe en la continuación de un discurso anterior o se desvía de él.

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See detailV. Van Saaze, Installation Art and the Museum : Presentation and Conservation of Changing Artworks
D'Haenens, Manon ULg

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2014), (9),

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See detailDevelopment and validation of a liquid chromatographic method for the stability study of a pharmaceutical formulation containing voriconazole using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector and polar organic mobile phases.
Servais, Anne-Catherine ULg; Moldovan, Radu-Cristian ULg; Farcas, Elena ULg et al

in Journal of chromatography. A (2014), 1363

The ophthalmic solution of voriconazole, i.e. (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-y l)butan-2-ol, made from an injection formulation which also contains ... [more ▼]

The ophthalmic solution of voriconazole, i.e. (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-y l)butan-2-ol, made from an injection formulation which also contains sulfobutylether-beta-cyclodextrin sodium salt as an excipient (Vfend((R))), is used for the treatment of fungal keratitis. A liquid chromatographic (LC) method using polar organic mobile phase and cellulose tris(4-chloro-3-methylphenylcarbamate) coated on silica as chiral stationary phase was successfully developed to evaluate the chiral stability of the ophthalmic solution. The percentage of methanol (MeOH) in the mobile phase containing acetonitrile (ACN) as the main solvent significantly influenced the retention and resolution of voriconazole and its enantiomer ((2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1- yl)butan-2-ol). The optimized mobile phase consisted of ACN/MeOH/diethylamine/trifluoroacetic acid (80/20/0.1/0.1; v/v/v/v). The method was found to be selective not only regarding the enantiomer of voriconazole but also regarding the specified impurities described in the monograph from the European Pharmacopoeia. The LC method was then fully validated applying the strategy based on total measurement error and accuracy profiles. Under the selected conditions, the determination of 0.1% of voriconazole enantiomer could be performed. Finally, a stability study of the ophthalmic solution was conducted using the validated LC method. [less ▲]

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See detailLa radicalité politique au bout du travail. Du suicide des ouvriers aux suicides en séries des employés
Cormann, Grégory ULg

in Quaderni : la Revue de la Communication (2014), 84

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See detailLe « trouble » de l’éjaculation précoce : Le critère d’une minute maximum de pénétration en question
Kempeneers, Philippe ULg; Desseilles, Martin ULg

in Sexologies : Revue Européenne de Santé Sexuelle = European Journal of Sexual Health (2014), 23

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio ... [more ▼]

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio-constitutional, and that long-term pharmacological treatment is the only viable option. However, the literature contains little scientific evidence to support this argument. In fact, a good number of individuals who suffer from overly rapid ejaculation present with penetration duration exceeding one minute, and even severe forms of PE have responded favourably to psycho-sexological treatment. Moreover, although certain biological variables are known to influence ejaculation latency time, nothing indicates that they play an exclusive role of psychosocial etiological factors in severe PE. Therefore, it would be ‘premature’ to base a PE diagnosis on a maximum penetration duration of one minute, which should instead be considered a severity gradient. Given that desired criteria for penetration duration often exceed biological norms, it would be inappropriate to propose that only the most severe forms of PE have constitutional origins. In any case, the constitution is relatively flexible, and can respond to adaptive learning. An adaptive learning approach would undoubtedly be more difficult to apply in severe cases, but not impossible. The issue of whether to use pharmacological versus psycho-sexological treatment could be side-stepped by moving beyond the single criterion of ejaculation latency. [less ▲]

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See detailHearing capacities and otolith size in two ophidiiform species (Ophidion rochei and Carapus acus)
Kever, Loïc ULg; Colleye, Orphal ULg; Herrel, Anthony et al

in Journal of Experimental Biology (2014), 217

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See detailContinuous glucose control in the ICU: report of a 2013 round table meeting.
Wernerman, Jan; Desaive, Thomas ULg; Finfer, Simon et al

in Critical care (London, England) (2014), 18(3), 226

Achieving adequate glucose control in critically ill patients is a complex but important part of optimal patient management. Until relatively recently, intermittent measurements of blood glucose have been ... [more ▼]

Achieving adequate glucose control in critically ill patients is a complex but important part of optimal patient management. Until relatively recently, intermittent measurements of blood glucose have been the only means of monitoring blood glucose levels. With growing interest in the possible beneficial effects of continuous over intermittent monitoring and the development of several continuous glucose monitoring (CGM) systems, a round table conference was convened to discuss and, where possible, reach consensus on the various aspects related to glucose monitoring and management using these systems. In this report, we discuss the advantages and limitations of the different types of devices available, the potential advantages of continuous over intermittent testing, the relative importance of trend and point accuracy, the standards necessary for reporting results in clinical trials and for recognition by official bodies, and the changes that may be needed in current glucose management protocols as a result of a move towards increased use of CGM. We close with a list of the research priorities in this field, which will be necessary if CGM is to become a routine part of daily practice in the management of critically ill patients. [less ▲]

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See detailRemote sensing of colour, temperature and salinity – new challenges and opportunities
Alvera Azcarate, Aïda ULg; Ruddick, Kevin; Minnett, Peter

in Remote Sensing of Environment (2014), 146

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See detailRapid aqueous synthesis of ordered mesoporous carbons: Investigation of synthesis variables and application as anode materials for Li-ion batteries
Léonard, Alexandre ULg; Gommes, Cédric ULg; Piedboeuf, Marie-Laure ULg et al

in Microporousand Mesoporous Materials (2014), 195

Ordered mesoporous carbons (OMC) were synthesized via a direct templating pathway by a synthesis route that features short duration, moderate temperature and aqueous media. Resorcinol was used as carbon ... [more ▼]

Ordered mesoporous carbons (OMC) were synthesized via a direct templating pathway by a synthesis route that features short duration, moderate temperature and aqueous media. Resorcinol was used as carbon precursor and hexamethylenetetramine as a source of formaldehyde and ammonia to respectively cross-link the framework and regulate the pH. The temperature of the heat treatment leading to the formation of the solid polymer was shown to have a strong influence on the structural and textural parameters. In particular, moderate temperatures led to the coexistence of differently-sized entangled hexagonal mesostructures, whereas the higher temperatures led to a sharp decrease in the mesopore volume. The performance of these materials as anode materials for Li-ion batteries has been investigated in detail. Although these OMC show reversible capacities similar to those reported for hard carbons, their long-term cycling remains very stable for over 100 cycles of charge/discharge. The optimization of the reported short preparation pathway offers new possibilities regarding the application of ordered mesoporous carbons in various fields, such as energy storage, sorption and heterogeneous catalysis [less ▲]

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See detailLa condition de l'article 263, alinéa 4, TFUE relative à l'absence de mesures d'exécution et l'arrêt Telefonica : de l'inutilité d'une réforme
Wildemeersch, Jonathan ULg

in Revue des Affaires Européennes [= RAE] = Law & European Affairs (2014), 2013(4), 861-871

L'auteur examine la portée de la condition relative à l'absence de mesures d'exécution de l'article 263, alinéa 4, in fine, TFUE au regard du premier arrêt de la Cour de justice de l'Union européenne ... [more ▼]

L'auteur examine la portée de la condition relative à l'absence de mesures d'exécution de l'article 263, alinéa 4, in fine, TFUE au regard du premier arrêt de la Cour de justice de l'Union européenne relatif à cette notion (CJUE, arrêt du 19 décembre 2013, Telefonica/Commission, aff. C-274/12 P). [less ▲]

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See detailEnhancing a CH-pi interaction to increase the affinity for 5-HT1A receptors
Liégeois, Jean-François ULg; Lespagnard, Marc; Meneses Salas, Elsa et al

in ACS Medicinal Chemistry Letters (2014), 5

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6 ... [more ▼]

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6-tetrahydropyridine (THP) analogue compared to the corresponding 4-phenylpiperazine analogue. To explore a possible reinforcement of this interaction to increase the affinity for 5-HT1A receptors, different 4-substituted-phenyl analogues were synthesized and tested. The most important increase of affinity is obtained with two electron-donating methyl groups in position 3 and 5 [less ▲]

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See detailIntroduction aux problèmes inverses
Charles, Catherine ULg

in Notes de Statistique et d'Informatique (2014)

cette note technique est une inititation aux problèmes inverses. Son objectif est d'expliquer au lecteur ses principes généraux, de montrer son large panel d'applications ainsi que de présenter ses ... [more ▼]

cette note technique est une inititation aux problèmes inverses. Son objectif est d'expliquer au lecteur ses principes généraux, de montrer son large panel d'applications ainsi que de présenter ses méthodes de résolution les plus courantes. [less ▲]

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See detailA superfast muscle in the complex sonic apparatus of Ophidion rochei (Ophidiiformes): histological and physiological approaches
Kever, Loïc ULg; Boyle, Kelly; Dragicevic, Branko et al

in Journal of Experimental Biology (2014), 214

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See detailEffect of Body Weight Loss on Cardiopulmonary Function assessed by 6-Minute Walk Test and Arterial Blood Gas Analysis in Obese Dogs
Manens; Ricci, R; Damoiseaux, C et al

in Journal of Veterinary Internal Medicine (2014), 28(2), 371-378

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See detailEffects of glucose-lowering agents on vascular outcomes in type 2 diabetes: A critical reappraisal.
Scheen, André ULg; Charbonnel, B.

in Diabetes & metabolism (2014)

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major ... [more ▼]

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain how hyperglycaemia induces vascular damage. However, randomized controlled trials investigating either an intensive glucose-lowering strategy vs standard care or the addition of a new glucose-lowering agent vs a placebo have largely failed to demonstrate any clinical benefits in terms of cardiovascular morbidity or mortality. This lack of evidence has led some people to contest the clinical efficacy of lowering blood glucose in patients with T2DM, despite its positive effects on microvascular complications. This article analyzes the various reasons that might explain such discrepancies. There are still strong arguments in favour of targeting hyperglycaemia while avoiding other counterproductive effects, such as hypoglycaemia and weight gain, and of integrating the glucose-lowering approach within a global multi-risk strategy to reduce the burden of cardiovascular disease in T2DM. [less ▲]

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See detailEffects of vitamin D in the elderly population : current status and perspectives
Bruyère, Olivier ULg; CAVALIER, Etienne ULg; Souberbielle, JC et al

in Archives of Public Health (2014), 72

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support ... [more ▼]

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case–control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated. [less ▲]

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See detailComparative study of volatile secondary metabolite of Cistus libanotis during different process
Zidane, H.; Fauconnier, Marie-Laure ULg; Sindic, Marianne ULg et al

in Journal of Chemical and Pharmaceutical Research (2014), 6(8), 281-287

Chemical composition of the essential oils of Cistus libanotis from eastern Morocco (Tafoughalt and Jerrada) extracted from different season was analyzed by GC-MS and GC-FID. The hydro-distilled essential ... [more ▼]

Chemical composition of the essential oils of Cistus libanotis from eastern Morocco (Tafoughalt and Jerrada) extracted from different season was analyzed by GC-MS and GC-FID. The hydro-distilled essential oil content ranged from 0, 27 % to 0, 46%, the maximum amounts were observed in summer while minimum in winter for Tafoughalt, whereas the oil obtained from Jerrada had the highest yield (0, 61 %). The essential oils consisted of terpineol-4 as the most abundant component (18, 70 % - 24, 91 %), followed by γ-terpinene (9, 82 % - 12, 25 %), camphene (5, 86 % - 13, 58 %), sabinene (7, 86 % - 9, 89 %) and α-thujene (6, 92 % - 10, 12 %). Samples collected in all seasons were found to be richer in monoterpenes hydrocarbons (52, 68 % - 57, 59 %). None sesquiterpene hydrocarbons found in the oils from summer and autumn. Drying period of leaves at normal air laboratory and distillation time also affect the oil content and composition. There was variation in terpineol-4 content from 22, 23 % (4th day of drying) to 19, 27 % (29th day of drying), and from 35, 60 % (1 hour of distillation) to 24, 17 % (4 hours of distillation). It can be concluded that the harvesting season, period of drying and the time of distillation had an effect on the yield of essential oil and chemical composition of various compounds. [less ▲]

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See detaille mythe de l'infaillibilité médicale menace sérieusement la sécurité du patient !
COUCKE, Philippe ULg

in Healthcare Executive (2014), 77

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See detailThe freeness problem over matrix semigroups and bounded languages
Charlier, Emilie ULg; Honkala, Juha

in Information & Computation (2014), 237

We study the freeness problem for matrix semigroups. We show that the freeness problem is decidable for upper-triangular 2 × 2 matrices with rational entries when the products are restricted to certain ... [more ▼]

We study the freeness problem for matrix semigroups. We show that the freeness problem is decidable for upper-triangular 2 × 2 matrices with rational entries when the products are restricted to certain bounded languages. [less ▲]

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See detailPulmonary rehabilitation and COPD: providing patients a good environment for optimizing therapy.
Corhay, Jean-Louis ULg; NGUYEN DANG, Delphine ULg; VAN CAUWENBERGE, Hélène ULg et al

in International journal of chronic obstructive pulmonary disease (2014), 9

Chronic obstructive pulmonary disease (COPD) is an obstructive and progressive airway disease associated with an important reduction in daily physical activity and psychological problems that contribute ... [more ▼]

Chronic obstructive pulmonary disease (COPD) is an obstructive and progressive airway disease associated with an important reduction in daily physical activity and psychological problems that contribute to the patient's disability and poor health-related quality of life (HRQoL). Nowadays, pulmonary rehabilitation (PR) plays an essential role in the management of symptomatic patients with COPD, by breaking the vicious circle of dyspnea-decreased activity-deconditioning-isolation. Indeed the main benefits of comprehensive PR programs for patients with COPD include a decrease in symptoms (dyspnea and fatigue), improvements in exercise tolerance and HRQoL, reduction of health care utilization (particularly bed-days), as well as an increase in physical activity. Several randomized studies and meta-analyses greatly established the benefits of PR, which additionally, is recommended in a number of influential guidelines. This review aimed to highlight the impact of PR on COPD patients, focusing on the clinical usefulness of PR, which provides patients a good support for change. [less ▲]

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See detailA new insight in the structure, composition and functioning of central African moist forests
Fayolle, Adeline ULg; Picard, Nicolas; Doucet, Jean-Louis ULg et al

in Forest Ecology & Management (2014), (329), 195-205

The greater part of the semi-deciduous moist forests of the Congo basin has been given to logging companies for exploitation. In the next decades, very few of these forests will remain intact. In this ... [more ▼]

The greater part of the semi-deciduous moist forests of the Congo basin has been given to logging companies for exploitation. In the next decades, very few of these forests will remain intact. In this paper, we aimed to identify large-scale variations in the structure, composition and functioning of African moist forests that could serve as a baseline for both management and conservation purposes. Commercial forest inventory data were assembled for 49,711 0.5-ha plots, covering an area of more than six million hectares, crossing the borders of Cameroon, Central African Republic and Republic of Congo. Floristic composition was analyzed for a subset of 176 genera reliably identified in the field. Three key functional traits of tropical trees: regeneration guild, leaf phenology, and wood specific gravity, were collected at the species level from various sources, and assigned at the genus level. We first investigated the main variations in forest structure and composition, and identified seven forest types based on these variations. Differences in the percentage of pioneer and deciduous stems, and mean wood specific gravity were tested between forest types. Most of the study area was composed of a mosaic of the structural variations of the forests characterized by the occurrence of Celtis (Ulmaceae) species, which are mostly composed of frequent and abundant genera that formed the common floristic pool of the region. Secondary Musanga (Moraceae) forest is located in repeatedly disturbed areas, along roads and around main cities; mixed Manilkara (Sapotaceae) forest covers a huge area in the southern Central African Republic and in the northern Republic of Congo; and monodominant Gilbertiodendron (Fabaceae) forest is sparsely distributed along rivers. The contrasted structure, composition, and functioning of the forest types imply pronounced differences in population and ecosystem processes, and call for adapted management and conservation strategies. [less ▲]

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See detailPharmacokinetics in patients with chronic liver disease and hepatic safety of incretin-based therapies for the management of type 2 diabetes mellitus.
Scheen, André ULg

in Clinical pharmacokinetics (2014), 53(9), 773-85

Patients with type 2 diabetes mellitus have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis, and about one-third of cirrhotic patients have ... [more ▼]

Patients with type 2 diabetes mellitus have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis, and about one-third of cirrhotic patients have diabetes. However, the use of several antidiabetic agents, such as metformin and sulphonylureas, may be a concern in case of hepatic impairment (HI). New glucose-lowering agents targeting the incretin system are increasingly used for the management of type 2 diabetes. Incretin-based therapies comprise oral inhibitors of dipeptidyl peptidase-4 (DPP-4) (gliptins) or injectable glucagon-like peptide-1 (GLP-1) receptor agonists. This narrative review summarises the available data regarding the use of both incretin-based therapies in patients with HI. In contrast to old glucose-lowering agents, they were evaluated in specifically designed acute pharmacokinetic studies in patients with various degrees of HI and their hepatic safety was carefully analysed in large clinical trials. Only mild changes in pharmacokinetic characteristics of DPP-4 inhibitors were observed in patients with different degrees of HI, presumably without major clinical relevance. GLP-1 receptor agonists have a renal excretion rather than liver metabolism. Specific pharmacokinetic data in patients with HI are only available for liraglutide. No significant changes in liver enzymes were reported with DPP-4 inhibitors or GLP-1 receptor agonists, alone or in combination with various other glucose-lowering agents, in clinical trials up to 2 years in length. On the contrary, preliminary data suggested that incretin-based therapies may be beneficial in patients with CLD, more particularly in the presence of non-alcoholic fatty liver disease. Nevertheless, caution should be recommended, especially in patients with advanced cirrhosis, because of a lack of clinical experience with incretin-based therapies in these vulnerable patients. [less ▲]

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See detailEffect of palm oil enzymatic interesterification on physicochemical and structural properties of mixed fat blends.
Danthine, Sabine ULg; Lefebure, Emilie ULg; Nhu Trin, Hoa et al

in Journal of the American Oil Chemists' Society (2014), 91

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