References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailA phase 1b study of trebananib in combination with pegylated liposomal doxorubicin or topotecan in women with recurrent platinum-resistant or partially platinum-sensitive ovarian cancer.
Vergote, Ignace; Schilder, Russell J.; Pippitt, Charles H. Jr et al

in Gynecologic oncology (2014), 135(1), 25-33

OBJECTIVE: To examine the tolerability and antitumor activity of trebananib plus pegylated liposomal doxorubicin (PLD) or topotecan in recurrent platinum-resistant or partially platinum-sensitive ovarian ... [more ▼]

OBJECTIVE: To examine the tolerability and antitumor activity of trebananib plus pegylated liposomal doxorubicin (PLD) or topotecan in recurrent platinum-resistant or partially platinum-sensitive ovarian cancer. METHODS: In this open-label phase 1b study, patients received trebananib 10mg/kg or 15mg/kg IV QW plus PLD 50mg/m(2) (cohorts A1 and A3, respectively) or topotecan 4mg/m(2) (cohorts B1 and B3, respectively). Endpoints were dose-limiting toxicity (DLT; primary); treatment-emergent adverse events (AEs), overall response rate, anti-trebananib antibodies, and pharmacokinetics (secondary). RESULTS: 103 patients were enrolled. One patient in A1 and B1 had DLTs. Across all cohorts, the most common AEs were nausea, fatigue, and peripheral edema. Across both trebananib plus PLD cohorts (A1/A3), grade 4 AEs were pulmonary embolism, disease progression, and anemia. Two patients had grade 5 intestinal perforation (n=1) and sudden death (n=1). Across both trebananib plus topotecan cohorts (B1/B3), grade 4 AEs were neutropenia, hypokalemia, decreased granulocyte count, chest pain, dyspnea, decreased neutrophil count, and pulmonary embolism. Two patients had grade 5 disease progression. One patient had grade 5 pleural effusion associated with progressive disease. Confirmed objective response rates were 36.0% (A1), 34.8% (A3), 16.7% (B1), and 0.0% (B3). Median progression-free survival duration (months) was 7.4 (A1), 7.1 (A3), 3.5 (B1), and 3.1 (B3), respectively. No drug-drug interactions were apparent. CONCLUSIONS: Trebananib 10mg/kg and 15mg/kg IV QW plus PLD or topotecan appear to have acceptable toxicity profiles in recurrent platinum-resistant or partially platinum-sensitive ovarian cancer. Antitumor activity was evident across all cohorts. [less ▲]

Detailed reference viewed: 27 (0 ULg)
Full Text
Peer Reviewed
See detailA new era of improving progression-free survival with dual blockade in postmenopausal HR, HER2 advanced breast cancer.
Jerusalem, Guy ULg; Bachelot, Thomas; Barrios, Carlos et al

in Cancer treatment reviews (2014)

Disease progression despite existing endocrine therapies remains a major challenge to the effective management of hormone-receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2 ... [more ▼]

Disease progression despite existing endocrine therapies remains a major challenge to the effective management of hormone-receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2-), advanced breast cancer. Recent advances in elucidating the molecular mechanisms of disease progression have identified the existence of adaptive "cross-talk" between the estrogen receptor (ER) and various growth factor receptor and intracellular signaling pathways, allowing breast cancer cells to escape the inhibitory effects of endocrine therapy. These findings provide the clinical rationale for enhancing or extending endocrine sensitivity by combining endocrine therapy with a targeted agent against a compensatory pathway. In BOLERO-2, adding the mTOR inhibitor everolimus to endocrine therapy significantly improved progression-free survival (PFS) in patients with HR+ advanced breast cancer previously treated with nonsteroidal aromatase inhibitor therapy. Notably, PFS benefits were comparable in subgroup analyses of first- and later-line settings. These results contrast with those of the large first-line HORIZON study, wherein adding the mTOR inhibitor temsirolimus to endocrine therapy did not improve PFS. Therefore, it is unclear whether a targeted agent should only be combined with endocrine therapy to restore endocrine sensitivity or whether it may also prevent or delay resistance in hormone-sensitive advanced breast cancer. Numerous additional targeted agents are currently being evaluated in combination with endocrine therapies, including PI3K, cyclin-dependent kinase 4/6, SRC, and histone deacetylase inhibitors. Appropriate patient selection based on prior treatment history will become increasingly important in maximizing the incremental benefit derived from these new agents combined with existing endocrine therapies in HR+ advanced breast cancer. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailCatastrophic antiphospholipid syndrome : case reports and review of the literature
GUNTZ, Julien; LAYIOS, Nathalie ULg; DAMAS, Pierre ULg

in Acta Anaesthesiologica Belgica (2014), 65

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailFeruloylbenzotriazole and Weinreb Amide as Bioinspired Building Blocks: A Reactivity Study towards O-, N-, S-, and C-Nucleophiles
Roman, Bart; Monbaliu, Jean-Christophe ULg; De Coen, Laurens et al

in European Journal of Organic Chemistry (2014)

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailNew Approach to Description of (d,xn) Spectra at energies below 50 MeV in Monte Carlo Simulation by Intra Nuclear Cascade Code with Distorted Wave Born Approximation
Hashimoto, S.; Iwamoto, Y.; Sato et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2014), 333

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailHeroin-assisted Tx superior to methadone for heroin addiction
Ansseau, Marc ULg

in Medscape medical news (2014)

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailGene expression pattern of synovial cells from inflammatory and normal areas of osteoarthritis synovial membrane.
Lambert, Cécile ULg; Dubuc, Jean-Emile; Montell, Eulalia et al

in Arthritis and Rheumatism (2014), sous presse

Objective: The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same ... [more ▼]

Objective: The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same osteoarthritis (OA) patient. Methods: Synovial tissues were obtained from 12 knee OA patients at the time of total knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria and sorted as N/R and I. Biopsies were cultured separately for 7 days. Microarray gene expression profiling between N/R and I areas was performed. Western blot and immunohistochemistry confirmed the identified genes that were differentially expressed. Results: 896 differentially expressed genes between N/R and I zones were identified. The key pathways were related to inflammation, cartilage metabolism, Wnt signaling and angiogenesis. In the inflammatory network, TREM1 and S100A9 were strongly up-regulated. MMP-3 and -9, cathepsin H and S were significantly up-regulated in the cartilage catabolism pathway, whereas the most up-regulated anabolism enzyme was HAS1. Wnt-5A and LRP5 were up-regulated whereas FZD2 and DKK3 were down-regulated in the Wnt signaling. Finally, STC1, a protein involved in angiogenesis was identified as the most up-regulated gene in I zones compared to N/R zones. Conclusion: This study is the first to identify different expression pattern between two areas of the synovial membrane in the same patient. These differences concern several key pathways involved in OA pathogenesis. This analysis also provides information regarding new genes and proteins as potential targets for the future therapeutic. (c) 2013 American College of Rheumatology. [less ▲]

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailErratum: Characterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogels (Microporous and Mesoporous Materials (2014) 184 (97-104))
Haghgoo, M.; Yousefi, A. A.; Zohouriaan Mehr, M. J. et al

in Microporous and Mesoporous Materials (2014), 195

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailCompte rendu de l'ouvrage de C. E. Barrett, "Egyptianizing Figurines from Delos. A Study in Hellenistic Religion"
Veymiers, Richard ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2014), 27

Detailed reference viewed: 16 (2 ULg)
Full Text
See detailGestion des cas, traitement et prévention chez les compagnons de pâture lors de myopathie atypique
van Galen, Gaby; Votion, Dominique ULg

in Pratique Vétérinaire Equine (2014), 46(182), 16-21

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailMeasuring the general phytosanitary situation: development of a plant health barometer
Wilmart, Olivier; Van Huffel, Xavier; Diricks, Herman et al

in European Journal of Plant Pathology (2014), Online First Articles

The development of a plant health barometer, an instrument to measure the general phytosanitary situation on a national level (Belgium) and on a yearly basis and to monitor its evolution over time, is ... [more ▼]

The development of a plant health barometer, an instrument to measure the general phytosanitary situation on a national level (Belgium) and on a yearly basis and to monitor its evolution over time, is described. The elaboration of a set of 13 plant health indicators (PHI’s) as the basis for the plant health barometer is discussed. These indicators were weighted by experts - including scientists, policy makers and agroindustrial representatives - to determine their relative impact in the barometer. The result of the barometer is expressed as a comparison with the previous year. Based on the results of the 13 PHI’s, it is concluded that the general plant health in Belgium shows a positive evolution from 2007 until 2010 and a negative evolution from 2010 until 2012. The plant health barometer provides a overview of the phytosanitary situation of plants and plant products in Belgium and is a tool to communicate in an intelligible, comprehensible manner on aspects of plant health to consumers and professional stakeholders in the plant production chain. Together with the food safety barometer and the animal health barometer, the plant health barometer is one of the three instruments to provide a overview on the general status of the safety of the food chain in Belgium. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailFirst Clarkforkian equivalent land mammal age in the latest Paleocene basal Sparnacian facies of Europe: Fauna, flora, paleoenvironment and (bio)stratigraphy
Smith, T.; Quesnel, F.; De Plöeg, G. et al

in PLoS ONE (2014), 9(1),

The Paleocene-Eocene Thermal Maximum (PETM) is correlated with the first occurrences of earliest modern mammals in the Northern Hemisphere. The latest Paleocene Clarkforkian North American Land Mammal Age ... [more ▼]

The Paleocene-Eocene Thermal Maximum (PETM) is correlated with the first occurrences of earliest modern mammals in the Northern Hemisphere. The latest Paleocene Clarkforkian North American Land Mammal Age, that has yielded rodents and carnivorans, is the only exception to this rule. However, until now no pre-PETM localities have yielded modern mammals in Europe or Asia. We report the first Clarkforkian equivalent Land Mammal Age in the latest Paleocene deposits of the basal Sparnacian facies at Rivecourt, in the north-central part of the Paris Basin. The new terrestrial vertebrate and macroflora assemblages are analyzed through a multidisciplinary study including sedimentologic, stratigraphic, isotopic, and palynological aspects in order to reconstruct the paleoenvironment and to evaluate biochronologic and paleogeographic implications. The mammals are moderately diverse and not abundant, contrary to turtles and champsosaurs. The macroflora is exceptional in preservation and diversity with numerous angiosperms represented by flowers, fruits, seeds and wood preserved as lignite material, revealing an abundance of Arecaceae, Betulaceae, Icacinaceae, Menispermaceae, Vitaceae and probably Cornaceae. Results indicate a Late Paleocene age based on carbon isotope data, palynology and vertebrate occurrences such as the choristoderan Champsosaurus, the arctocyonid Arctocyon , and the plesiadapid Plesiadapis tricuspidens. However, several mammal species compare better with the earliest Eocene. Among these, the particular louisinid Teilhardimys musculus, also recorded from the latest Paleocene of the Spanish Pyrenees, suggests a younger age than the typical MP6 reference level. Nevertheless, the most important aspect of the Rivecourt fauna is the presence of dental remains of a rodent and a "miacid" carnivoran, attesting to the presence of two modern mammalian orders in the latest Paleocene of Europe. Interestingly, these two groups are also the only modern groups recorded from the latest Paleocene of North America, making Rivecourt the first direct equivalent to the Clarkforkian Land Mammal Age outside of North America. © 2014 Smith et al. [less ▲]

Detailed reference viewed: 11 (4 ULg)
Full Text
Peer Reviewed
See detailMultitasking capacities in persons diagnosed with schizophrenia: A preliminary examination of their neurocognitive underpinnings and ability to predict real world functioning
Laloyaux, Julien ULg; Van der Linden, Martial ULg; Levaux, Marie-Noëlle ULg et al

in Psychiatry Research (2014), 217

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia and in particular during multitasking activities. However, at present, patients' multitasking capacities ... [more ▼]

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia and in particular during multitasking activities. However, at present, patients' multitasking capacities have not been adequately examined in the literature due to an absence of suitable assessment strategies. We thus recently developed a computerized real-life activity task designed to take into account the complex and multitasking nature of certain everyday life activities where participants are required to prepare a room for a meeting. Twenty-one individuals diagnosed with schizophrenia and 20 matched healthy controls completed the computerized task. Patients were also evaluated with a cognitive battery, measures of symptomatology and real world functioning. To examine the ecological validity, 14 other patients were recruited and were given the computerized version and a real version of the meeting preparation task. Results showed that performance on the computerized task was significantly correlated with executive functioning, pointing to the major implication of these cognitive processes in multitasking situations. Performance on the computerized task also significantly predicted up to 50% of real world functioning. Moreover, the computerized task demonstrated good ecological validity. These findings suggest the importance of evaluating multitasking capacities in patients diagnosed with schizophrenia in order to predict real world functioning. [less ▲]

Detailed reference viewed: 25 (7 ULg)
Full Text
Peer Reviewed
See detailHeart Valve Clinic: Rationale and Organization.
Lancellotti, Patrizio ULg; Rosenhek, Raphael; Pibarot, Philippe

in The Canadian journal of cardiology (2014)

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The ... [more ▼]

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The HVC is made up of a multidisciplinary team with high expertise in the diagnosis, management, treatment, and surveillance of patients with VHD. The aim of the HVC is to provide the highest quality of care to patients with VHD to improve the level of adherence to current evidence and guidelines, quality of life, and short- and long-term outcomes. The HVC also provides help in (1) informing and educating patients to motivate them to take their prescribed medications and look out for signs indicating a worsening of their disease, (2) organizing meetings for updates in knowledge for modern management of patients with VHD, and (3) disseminating protocols of contemporary and good practice in VHD. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailLichen-symbiotic cyanobacteria associated with Peltigera have an alternative vanadium-dependent nitrogen fixation-system
Hodkinson, Brendan P.; Allen, Jessica L.; Forrest, Laura L. et al

in European Journal of Phycology (2014), 49

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailMesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et al

in Nephrology Dialysis Transplantation (2014), 29

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]

Detailed reference viewed: 37 (17 ULg)
Full Text
Peer Reviewed
See detailFoundations and Scope of the Human Rights Obligations of the International Criminal Court: Brief Overview of an Unsettled Question
Deprez, Christophe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 3

Today, it goes undisputed that the International Criminal Court (ICC) is bound to abide by the individual rights of those that are affected by its judicial authority. The precise boundaries of this human ... [more ▼]

Today, it goes undisputed that the International Criminal Court (ICC) is bound to abide by the individual rights of those that are affected by its judicial authority. The precise boundaries of this human rights constraint, however, still lack clarity. In particular, there is no consensus on the theoretical basis for such an obligation, especially given the fact that the Court is not party to the relevant international and regional instruments. Because theory dictates content, it also remains unclear what the actual substance of the Court’s obligations is. This twofold question of the foundations and substantive scope of the ICC’s human rights constraint has only received limited attention so far. This article aims to contribute to remedy this lacuna. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailSpray-drying synthesis of Na2FePO4F/carbon powders for lithium-ion batteries
Brisbois, Magali ULg; Krins, Natacha ULg; Hermann, Raphael et al

in Materials Letters (2014), 130

Sodium iron fluorophosphate Na2FePO4F is a candidate positive electrode material for both lithium-ion batteries and sodium-ion batteries. We report the synthesis of Na2FePO4F/carbon powders by the simple ... [more ▼]

Sodium iron fluorophosphate Na2FePO4F is a candidate positive electrode material for both lithium-ion batteries and sodium-ion batteries. We report the synthesis of Na2FePO4F/carbon powders by the simple and easily up-scalable technique of spray-drying. An aqueous solution containing citric acid as a carbon source was sprayed in a pilot-scale spray-dryer. Heat treatment at 600°C in argon for 12 hours was found appropriate to obtain single-phase Na2FePO4F; only 1.8% of Fe (III) were detected by iron-57 Mössbauer spectroscopy. When cycled against lithium, the discharge capacity reached 110 mAh g-1 at C/15 rate. (C) 2014 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 53 (13 ULg)
Full Text
Peer Reviewed
See detailCulture and hallucinations: overview and future directions
Laroi, Frank ULg; Luhrmann, T; Bell, V et al

in Schizophrenia Bulletin (2014), 40

Detailed reference viewed: 16 (3 ULg)
Full Text
Peer Reviewed
See detailAnalyse des caractéristiques biopsychosociales observées chez 1 832 patients consultant pour des douleurs chroniques dans le service d'algologie du CHU de Liège
Faymonville, Marie-Elisabeth ULg; Blavier, Adelaïde ULg; PALMARICCIOTTI, Valérie ULg et al

in Douleur et Analgésie (2014), 27

This article aims to establish a "profile" of patients presenting with chronic pain in the algology service of CHU of Liège to identify possible relationships between diagnoses, psychological states and ... [more ▼]

This article aims to establish a "profile" of patients presenting with chronic pain in the algology service of CHU of Liège to identify possible relationships between diagnoses, psychological states and modes of pain management. Between 2005 and 2010 we monitored 1832 individual chronic pain patients who attended our pain clinic at the University Hospital of Liège. This paper presents the characteristics of these patients and their test scores before the treatment to assess their health status in a biopsychosocial perspective. Demographic and lifestyle as well as occupational factors, pain disability index, pain belief assessment, hospital anxiety and depression scale, SF-36 (Short Form Health Survey) and pain visual analogue scale are presented. The results have clinical implication; they suggest an adaptation of our therapeutic interventions based on these observations. © 2014 Springer-Verlag France. [less ▲]

Detailed reference viewed: 85 (20 ULg)
Full Text
Peer Reviewed
See detailAnalysis of on-pump and off-pump surgery in the Arterial Revascularization Trial.
Poullis, Michael; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2014)

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailFirst-principles characterization of the P21ab ferroelectric phase of Aurivillius Bi2WO6
Djani-Ait, Hania ULg; Hermet, Patrick ULg; Ghosez, Philippe ULg

in Journal of Physical Chemistry C (2014), 118

The structural, dielectric, dynamical, elastic, piezoelectric and nonlinear optical (second-order susceptibility and Pockels tensors) properties of Bi2WO6 in its P21ab ferroelectric ground state are ... [more ▼]

The structural, dielectric, dynamical, elastic, piezoelectric and nonlinear optical (second-order susceptibility and Pockels tensors) properties of Bi2WO6 in its P21ab ferroelectric ground state are determined using density functional theory. The calculation of infrared and Raman spectra on single crystal allowed us to clarify the assignment of experimental phonon modes, considering the good agreement between the calculated and the experimental Raman spectra obtained on polycrystal. The calculation of the elastic constants con rms the elastic stability of the crystal and allow us to estimate the Young and shear moduli of polycrystalline samples. The piezoelectric constants have signi cant intrinsic values comparable to those of prototypical ABO3 ferroelectrics. The electro-optic response is strongly dominated by the ionic contribution of transverse optic modes, yielding sizable Pockels coe cients around 9 pm/V along the polar direction. [less ▲]

Detailed reference viewed: 6 (2 ULg)
Full Text
See detailL’evidence-based practice à portée des orthophonistes : intérêt des recommandations pour la pratique clinique
Maillart, Christelle ULg; Durieux, Nancy ULg

in Rééducation Orthophonique (2014), 257

La démarche evidence-based practice (EBP) littéralement « pratique basée sur des preuves », a pour objectif d’aider le clinicien à optimiser ses choix thérapeutiques en s’appuyant sur des données ... [more ▼]

La démarche evidence-based practice (EBP) littéralement « pratique basée sur des preuves », a pour objectif d’aider le clinicien à optimiser ses choix thérapeutiques en s’appuyant sur des données objectives issues de la recherche tout en tenant compte de la situation clinique. Néanmoins, la méthodologie complète de récolte et d’analyse des données est complexe et chronophage, ce qui est un frein réel pour son application en clinique. Pour remédier à cela, des synthèses scientifiquement motivées, appelées des recommandations de pratique clinique (RPC) ou guidelines, se développent et jouent alors un rôle essentiel pour l’actualisation des connaissances des professionnels. Cet article s’intéresse particulièrement aux recommandations pour la pratique clinique et au rôle qu’elles peuvent jouer dans la sensibilisation des cliniciens au recours à une démarche EBP. [less ▲]

Detailed reference viewed: 108 (14 ULg)
Full Text
Peer Reviewed
See detailAb initio calculation of the thermal conductivity of indium antimonide
Miranda, Alonso L.; Xu, Bin ULg; Hellman, Olle et al

in Semiconductor Science and Technology (2014), 29(12), 124002

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailBrains creating stories of selves: the neural basis of autobiographical reasoning.
D'Argembeau, Arnaud ULg; Cassol, Helena; Phillips, Christophe ULg et al

in Social Cognitive and Affective Neuroscience (2014), 9

Personal identity critically depends on the creation of stories about the self and one's life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the ... [more ▼]

Personal identity critically depends on the creation of stories about the self and one's life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the construction of such narratives. During fMRI scanning, participants approached a set of personally significant memories in two different ways: on some trials, they remembered the concrete content of the events (autobiographical remembering), whereas on other trials they reflected on the broader meaning and implications of their memories (autobiographical reasoning). Relative to remembering, autobiographical reasoning recruited a left-lateralized network involved in conceptual processing (including the dorsal medial prefrontal cortex (MPFC), inferior frontal gyrus, middle temporal gyrus, and angular gyrus). The ventral MPFC-an area that may function to generate personal/affective meaning-was not consistently engaged during autobiographical reasoning across participants but, interestingly, the activity of this region was modulated by individual differences in interest and willingness to engage in self-reflection. These findings support the notion that autobiographical reasoning and the construction of personal narratives go beyond mere remembering in that they require deriving meaning and value from past experiences. [less ▲]

Detailed reference viewed: 66 (9 ULg)
Full Text
Peer Reviewed
See detailContrasting biogeochemical characteristics of the Oubangui River and tributaries (Congo River basin)
Bouillon, Steven; Yambélé, Athanase; Gillikin, David P. et al

in Scientific Reports (2014), 4

The Oubangui is a major tributary of the Congo River. We describe the biogeochemistry of contrasting tributaries within its central catchment, with watershed vegetation ranging from wooded savannahs to ... [more ▼]

The Oubangui is a major tributary of the Congo River. We describe the biogeochemistry of contrasting tributaries within its central catchment, with watershed vegetation ranging from wooded savannahs to humid rainforest. Compared to a 2-year monitoring record on the mainstem Oubangui, these tributaries show a wide range of biogeochemical signatures, from highly diluted blackwaters (low turbidity, pH, conductivity, and total alkalinity) in rainforests to those more typical for savannah systems. Spectral analyses of chromophoric dissolved organic matter showed wide temporal variations in the Oubangui compared to spatio-temporal variations in the tributaries, and confirm that different pools of dissolved organic carbon are mobilized during different hydrological stages. d13C of dissolved inorganic carbon ranged between -28.1 per mil and -25.8 per mil, and was strongly correlated to both partial pressure of CO2 and to the estimated contribution of carbonate weathering to total alkalinity, suggesting an important control of the weathering regime on CO2 fluxes. All tributaries were oversaturated in dissolved greenhouse gases (CH4, N2O, CO2), with highest levels in rivers draining rainforest. The high diversity observed underscores the importance of sampling that covers the variability in subcatchment characteristics, to improve our understanding of biogeochemical cycling in the Congo Basin. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailEffects of visual cortex activation on the nociceptive blink reflex in healthy subjects.
Sava, Simona L.; de Pasqua, Victor; MAGIS, Delphine ULg et al

in PloS one (2014), 9(6), 100198

Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not ... [more ▼]

Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not known. To address this issue in healthy human subjects we modulated differentially visual cortex activity by repetitive transcranial magnetic stimulation (rTMS) or flash light stimulation, and studied the effect on supraorbital pain thresholds and the nociceptive-specific blink reflex (nBR). Low frequency rTMS that inhibits the underlying cortex, significantly decreased pain thresholds, increased the 1st nBR block ipsi- and contralaterally and potentiated habituation contralaterally. After high frequency or sham rTMS over the visual cortex, and rMS over the right greater occipital nerve we found no significant change. By contrast, excitatory flash light stimulation increased pain thresholds, decreased the 1st nBR block of ipsi- and contralaterally and increased habituation contralaterally. Our data demonstrate in healthy subjects a functional relation between the visual cortex and the trigeminal nociceptive system, as assessed by the nociceptive blink reflex. The results argue in favour of a top-down inhibitory pathway from the visual areas to trigemino-cervical nociceptors. We postulate that in normal conditions this visuo-trigeminal inhibitory pathway may avoid disturbance of vision by too frequent blinking and that hypoactivity of the visual cortex for pathological reasons may promote headache and photophobia. [less ▲]

Detailed reference viewed: 4 (1 ULg)
Full Text
See detailDeletion of exons 1-3 of the MEN1 gene in a large Italian family causes the loss of menin expression.
Zatelli, Maria Chiara; Tagliati, Federico; Di Ruvo, Mauro et al

in Familial cancer (2014)

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to ... [more ▼]

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to inactivating mutations of the MEN1 gene (chromosome 11q13). MEN1 mutations are mainly represented by nonsense, deletions/insertions, splice site or missense mutations that can be detected by direct sequencing of genomic DNA. However, MEN1 patients with large heterozygous deletions may escape classical genetic screening and may be misidentified as phenocopies, thereby hindering proper clinical surveillance. We employed a real-time polymerase chain reaction application, the TaqMan copy number variation assay, to evaluate a family in which we failed to identify an MEN1 mutation by direct sequencing, despite a clear clinical diagnosis of MEN1 syndrome. Using the TaqMan copy number variation assay we identified a large deletion of the MEN1 gene involving exons 1 and 2, in three affected family members, but not in the other nine family members that were to date clinically unaffected. The same genetic alteration was not found in a group of ten unaffected subjects, without family history of endocrine tumors. The MEN1 deletion was further confirmed by multiplex ligation-dependent probe amplification, which showed the deletion extended from exon 1 to exon 3. This new approach allowed us to correctly genetically diagnose three clinical MEN1 patients that were previously considered as MEN1 phenocopies. More importantly, we excluded the presence of genetic alterations in the unaffected family members. These results underline the importance of using a variety of available biotechnology approaches when pursuing a genetic diagnosis in a clinically suggestive setting of inherited endocrine cancer. [less ▲]

Detailed reference viewed: 38 (7 ULg)
Full Text
Peer Reviewed
See detailQUELLE EST LA PLACE DE L’HUMAIN AU SEIN DES RECOMMANDATIONS, DES CONCERTATIONS ONCOLOGIQUES
BARTHELEMY, Nicole ULg; BOGA, Deniz ULg; PRINCEN, Fabienne ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 9-12

Le patient atteint de cancer bénéficie à l’heure actuelle d’une médecine très technique, de plus en plus ciblée et individualisée. Et l’Homme dans tout cela ? Divers outils ont été développés afin d’aider ... [more ▼]

Le patient atteint de cancer bénéficie à l’heure actuelle d’une médecine très technique, de plus en plus ciblée et individualisée. Et l’Homme dans tout cela ? Divers outils ont été développés afin d’aider les médecins et l’ensemble des soignants à concilier la médecine contemporaine et les droits fondamentaux du patient. Parmi ceux-ci, on trouve les Concertations Oncologiques Multidisciplinaires (COM) ainsi que les recommandations de traitement publiées par les socié - tés scientifiques nationales ou internationales. La prise en charge des patients doit être interdisciplinaire et basée sur une médecine factuelle. Ce processus de prise de décisions parta - gée doit, au final, être en accord avec les souhaits du patient. Cette approche doit lui permettre de conserver son autonomie et d’être l’acteur principal dans les prises de décision. [less ▲]

Detailed reference viewed: 36 (7 ULg)
Full Text
Peer Reviewed
See detailA frontal approach to hex-dominant mesh generation
Baudouin, Tristan Carrier; Remacle, Jean-François; Marchandise, Emilie et al

in Advanced Modeling and Simulation in Engineering Sciences (2014), 1(1), 1-30

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailImportance of temporal variability for hydrological predictions based on the maximum entropy production principle
Westhoff, Martijn ULg; Zehe, Erwin; Schymanski, Stanislaus J.

in Geophysical Research Letters (2014)

This work builds on earlier work by Kleidon and Schymanski (2008) who explored the use of the maximum entropy production (MEP) principle for modeling hydrological systems. They illustrated that MEP can be ... [more ▼]

This work builds on earlier work by Kleidon and Schymanski (2008) who explored the use of the maximum entropy production (MEP) principle for modeling hydrological systems. They illustrated that MEP can be used to determine the partitioning of soil water into runoff and evaporation—which determines hydroclimatic conditions around the Globe—by optimizing effective soil and canopy conductances in a way to maximize entropy production by these fluxes. In the present study, we show analytically that under their assumption of constant rainfall, the proposed principle always yields an optimum where the two conductances are equal, irrespective of rainfall rate, evaporative demand, or gravitational potential. Subsequently, we show that under periodic forcing or periodic variations in one resistance (e.g., vegetation seasonality), the optimal conductance does depend on climatic drivers such as the length of dry spells or the time of closure of stomata. [less ▲]

Detailed reference viewed: 3 (2 ULg)
Full Text
Peer Reviewed
See detailRomosozumab in Postmenopausal Women with Low Bone Mineral Density.
McClung, Michael R.; Grauer, Andreas; Boonen, Steven et al

in The New England journal of medicine (2014), 370

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. Methods In a phase 2, multicenter ... [more ▼]

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. Methods In a phase 2, multicenter, international, randomized, placebo-controlled, parallel-group, eight-group study, we evaluated the efficacy and safety of romosozumab over a 12-month period in 419 postmenopausal women, 55 to 85 years of age, who had low bone mineral density (a T score of -2.0 or less at the lumbar spine, total hip, or femoral neck and -3.5 or more at each of the three sites). Participants were randomly assigned to receive subcutaneous romosozumab monthly (at a dose of 70 mg, 140 mg, or 210 mg) or every 3 months (140 mg or 210 mg), subcutaneous placebo, or an open-label active comparator - oral alendronate (70 mg weekly) or subcutaneous teriparatide (20 mug daily). The primary end point was the percentage change from baseline in bone mineral density at the lumbar spine at 12 months. Secondary end points included percentage changes in bone mineral density at other sites and in markers of bone turnover. Results All dose levels of romosozumab were associated with significant increases in bone mineral density at the lumbar spine, including an increase of 11.3% with the 210-mg monthly dose, as compared with a decrease of 0.1% with placebo and increases of 4.1% with alendronate and 7.1% with teriparatide. Romosozumab was also associated with large increases in bone mineral density at the total hip and femoral neck, as well as transitory increases in bone-formation markers and sustained decreases in a bone-resorption marker. Except for mild, generally nonrecurring injection-site reactions with romosozumab, adverse events were similar among groups. Conclusions In postmenopausal women with low bone mass, romosozumab was associated with increased bone mineral density and bone formation and with decreased bone resorption. (Funded by Amgen and UCB Pharma; ClinicalTrials.gov number, NCT00896532 .). [less ▲]

Detailed reference viewed: 41 (9 ULg)
See detailEvidence-based practice: fondements et réflexions sur l’apport en clinique.
Maillart, Christelle ULg; Durieux, Nancy ULg

in Langage et Pratiques (2014), 53

L’evidence-based practice ou pratique basée sur les preuves est une approche de plus en plus encouragée en logopédie au niveau international. Cet article présente les principaux composants en détaillant ... [more ▼]

L’evidence-based practice ou pratique basée sur les preuves est une approche de plus en plus encouragée en logopédie au niveau international. Cet article présente les principaux composants en détaillant la nature des preuves liées aux trois piliers de l’EBP (preuves externes, preuves internes ou préférences du patient). La démarche de l’EBP est brièvement discutée ainsi que les freins et les bénéfices attendus en clinique. [less ▲]

Detailed reference viewed: 70 (20 ULg)
Full Text
Peer Reviewed
See detailInsight into the development of a carbonate platform through a multi-disciplinary approach - A case study from the Upper Devonian slope deposits of Mount Freikofel (Carnic Alps, Austria/Italy)
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Suttner, Thomas et al

in International Journal of Earth Sciences (2014), 103

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental ... [more ▼]

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental changes that occur in geological past is still limited. We herein undertake a multi-disciplinary approach (sedimentology, conodont biostratigraphy, magnetic susceptibility and geochemistry) of a long-term succession in the Carnic Alps which offers new insights into the peculiar evolution of one of the best example of Palaeozoic carbonate platform in Europe. The Freikofel section, located in the central part of the Carnic Alps represents an outstanding succession in a fore-reef setting, extending from the latest Givetian (indet. falsiovalis conodont Zones) to the early Famennian (Lower crepida conodont Zone). Sedimentological analysis allowed to propose a sedimentary model dominated by distal slope and fore-reef slope deposits. The most distal setting is characterized by an autochthonous pelagic sedimentation showing local occurrence of thin-bedded turbiditic deposits. In the fore-reef slope, in a more proximal setting, there is an accumulation of various autochthonous and allochthonous fine- to coarse-grained sediments originated from the interplay of gravity-flow currents derived from the shallow-water and deeper-water area. The temporal evolution of microfacies in the Freikofel section evolves in two main steps corresponding to the Freikofel (Unit 1) and the Pal (Unit 2) Limestones. Distal slope to fore-reef lithologies and associate changes are from base to top of the section: (U1) thick bedded litho- and bioclastic breccia beds with local fining upward sequence and fine-grained mudstone intercalations corresponding, in the fore-reef setting, to the dismantlement of the Eifelian – Frasnian carbonate platform during the early to late Frasnian time (falsiovalis to rhenana superzones) with one of the causes being the Late Givetian major rift pulse; (U2) occurrence of thin-bedded red nodular and cephalopod-bearing limestones with local lithoclastic grainstone intercalations corresponding to a significant deepening of the area and the progressive withdrawal of sedimentary influxes toward the basin, in relation with late Frasnian sea-level rise. Magnetic susceptibility and geochemical analyses were also performed along the Freikofel section and demonstrate the inherent-parallel link existing between variation in magnetic susceptibility values and proxy for terrestrial input. Interpretation of magnetic susceptibility in term of palaeoenvironmental processes reflect that even though distality remains the major parameter influencing magnetic susceptibility values, carbonate production and water agitation also play an important role. [less ▲]

Detailed reference viewed: 30 (10 ULg)
Full Text
Peer Reviewed
See detailThe Mental Whiteboard Hypothesis on Serial Order in Working Memory
Abrahamse, Elger; Van Dijck, Jean-Philippe; Majerus, Steve ULg et al

in Frontiers in Human Neuroscience (2014), 8

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailStudy of residual stresses in bimetallic work rolls
Neira Torres, Ingrid ULg; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in Advanced Materials Research (2014), 996

An experimental campaign of compression tests, differential thermal analysis (DTA), differential scanning calorimetry ( DSC), dilatometry and microstructure analysis has been performed, as well as the ... [more ▼]

An experimental campaign of compression tests, differential thermal analysis (DTA), differential scanning calorimetry ( DSC), dilatometry and microstructure analysis has been performed, as well as the identification of the material data set for finite element ( FE) analysis of bimetallic rolls. This article numerically investigates the stress and strain fields after the cooling stage and it checks their effect on the subsequent heat treatment step. As bimetallic rolls have a different material for core and shell, the effect of the roll size and the shell thickness on residual stresses is also studied. [less ▲]

Detailed reference viewed: 25 (14 ULg)
Full Text
Peer Reviewed
See detailDeterminant of fat mass percentage and absolute fat-free mass in preterm infants at the time of hospital discharge
Simon, Laure; Frondas-Chauty, Anne; SENTERRE, Thibault ULg et al

in American Journal of Clinical Nutrition (2014), 100(1), 98-104

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailCharacterization and modeling of a scroll expander with air and ammonia as working fluid
Mendoza, Luis Carlos; Navarro-Esbrí; Bruno, Joan Carles et al

in Applied Thermal Engineering (2014), 70

This paper presents the experimental characterization and modeling of a scroll expander. The expander used here is a scroll compressor modified to work as an expander. It is characterized in two ... [more ▼]

This paper presents the experimental characterization and modeling of a scroll expander. The expander used here is a scroll compressor modified to work as an expander. It is characterized in two experimental setups using air and ammonia as working fluids. The paper studies how the main operating variables (supply pressure and temperature, pressure ratio, rotational speed and lubrication) influence the performance of the scroll expander. A semi-empirical model is proposed to determine the scroll expander performance. This model uses some semi-empirical parameters (such as built-in volume ratio, leakage area and mechanical losses), obtained through experimentation, to calculate the mechanical power, supply mass flow rate and exhaust temperature. Using this semi-empirical model, the deviations in the calculated mechanical power, exhaust temperature and supply mass flow rate are ±9%, ±4 K and ±5% Hz. [less ▲]

Detailed reference viewed: 94 (6 ULg)
Full Text
Peer Reviewed
See detailA proposal of a vulnerability index in the pastoral food system in the Republic of Niger : case of the Department of Abalak
Andres, Ludovic ULg; Bodé, Sambo; Du Faux, Judith ULg et al

in Agriculture and Forestry (2014), 60(4), 35-42

In the Republic of Niger, livestock is an important economic activity for a large number of Nigerian households. Indeed, the livestock products are the main export products with the agriculture, the ... [more ▼]

In the Republic of Niger, livestock is an important economic activity for a large number of Nigerian households. Indeed, the livestock products are the main export products with the agriculture, the uranium and the oil. In 2013, the primary sector represented 49% of the Gross Domestic Product (GDP). However, the livestock activities are disrupted because of many droughts, especially the droughts of 1970 and 1980. Besides that, the pastoral vulnerability keeps very important in Niger and the characterization of this vulnerability is not adapted to the pastoral context (Andres L. and Lebailly Ph., 2013c; Yamba B. et al., 2013). This paper attempts to describe the specific factors related to the pastoral vulnerability. This assessment of the pastoral vulnerability has been based upon two livestock systems: sedentary and mobile herds. This evaluation has certain limitations. These limitations can be ascribed to the difficulties in accessing the pastoral areas and in identifying many factors of each pastoral food system. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
See detailSerum Vascular Endothelial Growth Factor is Selectively Upregulated in Patients with Biopsy-Proven Giant Cell Arteritis
Morlet, Julien; Mahoney, David; Zarei, Ali et al

in Rheumatology (2014), 53(1), 188-188

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailLa santé bucco-dentaire des personnes âgées
Lamy, Marc ULg

in Revue Médicale de Liège (2014)

La santé bucco-dentaire est mauvaise chez les personnes âgées, qu’elles vivent à domicile, ou, plus encore, en milieu institutionnalisé. La prévalence des patients édentés totaux est presque toujours ... [more ▼]

La santé bucco-dentaire est mauvaise chez les personnes âgées, qu’elles vivent à domicile, ou, plus encore, en milieu institutionnalisé. La prévalence des patients édentés totaux est presque toujours supérieure à 50 % et le nombre moyen de dents présentes en bouche, chez les patients dentés, est de dix. Cette situation a des conséquences sur la qualité de vie, la nutrition, les maladies cardiovasculaires et les pneumopathies des personnes âgées. Des mesures doivent être mises en place pour changer ce triste constat. [less ▲]

Detailed reference viewed: 44 (6 ULg)
Full Text
Peer Reviewed
See detailSarcopenia: burden and challenges for public health
Beaudart, Charlotte ULg; Rizzoli, R; Bruyère, Olivier ULg et al

in Archives of Public Health (2014), 72

Sarcopenia, operationally defined as the loss of muscle mass and muscle function, is a major health condition associated with ageing, and contributes to many components of public health at both the ... [more ▼]

Sarcopenia, operationally defined as the loss of muscle mass and muscle function, is a major health condition associated with ageing, and contributes to many components of public health at both the patient and the societal levels. Currently, no consensual definition of sarcopenia exists and therefore it is still a challenge to establish the actual prevalence of sarcopenia or to establish the direct and indirect impacts of sarcopenia on public health. Anyway, this geriatric syndrome represents a huge potential public health issue because of its multiple clinical and societal consequences. Moreover, all these aspects have an impact on healthcare costs both for the patient and the society. Therefore, the implementation of effective and broadly applicable preventive and therapeutic interventions has become a medical and societal challenge for the growing number of older persons affected by sarcopenia and its disabling complications. [less ▲]

Detailed reference viewed: 11 (2 ULg)
Full Text
Peer Reviewed
See detailImportance of concomitant local and systemic eosinophilia in uncontrolled asthma.
SCHLEICH, FLorence ULg; Chevremont, Anne; Paulus, Virginie et al

in The European respiratory journal (2014), 44

Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic eosinophilia. In this study, we sought to determine the ... [more ▼]

Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic eosinophilia. In this study, we sought to determine the prevalence and characteristics of patients with concordant and discordant systemic and bronchial eosinophilia.We conducted a retrospective study on 508 asthmatics with successful sputum induction. We assessed the relationship between blood and sputum eosinophils by breaking down the population into four groups according to blood (>/=400 cells per mm3) and sputum (>/=3%) eosinophils. Then, we prospectively reassessed the link between eosinophils and asthma control (Asthma Control Questionnaire (ACQ)) and exacerbation rate in a new cohort of 250 matched asthmatics.In our retrospective cohort, asthmatics without eosinophilic inflammation were the largest group (49%). The group with isolated sputum eosinophilia (25%) was, compared with noneosinophilic asthma, associated with lower forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity ratio and higher bronchial hyperresponsiveness and exhaled nitric oxide fraction (FeNO). Asthmatics exhibiting isolated systemic eosinophilia (7%) had similar characteristics as noneosinophilic asthmatics. The group with concordant systemic and airway eosinophilia (19%) showed remarkable male predominance, and had the lowest airway calibre, ACQ score and quality of life, and the highest bronchial hyperresponsiveness, FeNO and exacerbation rate. The prospective cohort confirmed the different subgroup proportions and the higher ACQ and exacerbation rates in cases of diffuse eosinophilia compared with noneosinophilic asthmatics.Concomitant systemic and bronchial eosinophilic inflammation contribute to poor asthma control. [less ▲]

Detailed reference viewed: 27 (19 ULg)
Full Text
Peer Reviewed
See detailLe medicament du mois. Le lixisenatide (Lyxumia): nouvel agoniste des recepteurs du glucagon-like peptide-1 a action preferentiellement post-prandiale.
Scheen, André ULg

in Revue medicale de Liege (2014), 69(2), 102-9

Lixisenatide (Lyxumia) is a new agonist of Glucagon-Like Peptide-1 (GLP-1) receptors that is indicated in the treatment of type 2 diabetes, in one single subcutaneous daily injection of 20 microg. It ... [more ▼]

Lixisenatide (Lyxumia) is a new agonist of Glucagon-Like Peptide-1 (GLP-1) receptors that is indicated in the treatment of type 2 diabetes, in one single subcutaneous daily injection of 20 microg. It exerts an incretin effect by stimulating insulin secretion after a meal while inhibiting glucagon secretion, both in a glucose-dependent manner, which limits the risk of hypoglycaemia. In addition, it slows down gastric emptying after a meal, which contributes to reduce postprandial hyperglycaemia, especially after breakfast. Lixisenatide is currently reimbursed in Belgium after failure of a dual therapy with metformin and a sulfonylurea but also in combination with a basal insulin (with or without oral antidiabetic drugs). The latter interesting combination should tackle fasting glycaemia with basal insulin (after appropriate dose titration) and postprandial hyperglycaemia with the GLP-1 receptor agonist in a complementary manner. The consequence is a further improvement of glycated haemoglobin (HbA(1c)) varying between 0.3 and 0.9% in various studies comparing lixisenatide versus placebo. As other compounds of the class, lixisenatide induces a small weight reduction, which contrasts with the weight gain commonly observed with other antidiabetic medications (including insulin). Further studies should demonstrate the effects of lixisenatide on vascular complications and overall prognosis of patients with type 2 diabetes. [less ▲]

Detailed reference viewed: 34 (0 ULg)
Full Text
Peer Reviewed
See detailControl of citrus blue mold by the antagonist yeast Pichia guilliermondii Z1: compatibility with commercial fruit waxes and putative mechanisms of action.
Lahlali, Rachid; Hamadi, Younes; Drider, R. et al

in Food Control (2014), 45

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an ... [more ▼]

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an alternative for synthetic fungicides, would be compatible with other postharvest practices used commercially. In particular, commercial fruit waxes can reduce their survival and effectiveness. The commercial fruit waxes tested, in combination at 20% with strain Z1, included microcrystalline, ester gum, candelilla, beeswax, montan, paraffin, rice bran, rosin maleic, carnauba, shellac, and one mixture shellac plus carnauba. Beeswax, paraffin, rosin maleic, carnauba, and shellac increased significantly strain Z1 survival in Petri dish assays. Candelilla, beeswax, rice bran, rosin maleic, carnauba, shellac, and shellacecarnauba mixture did not significantly reduce the strain Z1 yield on orange fruit surfaces compared to other waxes. With the exception of rosin maleic wax, none of the commercial fruit waxes or mixture increased significantly the ability of the formulated product of strain Z1 to control the postharvest pathogen Penicillium italicum on wounded orange fruit. When the formulated product of strain Z1 was used in combination with beeswax, strain Z1 retained the same efficacy. In contrast, microcrystalline, ester gum, candelilla, montan, paraffin, rice bran, carnauba, shellac, and shellac-carnauba mixture significantly reduced the effectiveness of the formulated product of strain Z1. No antibiosis was detected for strain Z1 against P. italicum. Strain Z1 inhibited the spore germination for the low juice concentration (up to 5%) when compared to the control. However, the addition of fresh juice after antagonist removal allowed the restoration of the germination of P. italicum spores; suggesting the possibility of competition for nutrients in the biocontrol activity of strain Z1. The study demonstrates the potential commercial application of strain Z1 with beeswax and rosin maleic wax for postharvest control of citrus blue mold. As biocontrol relies on competition for nutrients, an enriched formulation with nutrients is needed for reliable antifungal activity of this yeast strain [less ▲]

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailImpairment of symbiont photosynthesis increases host cell proliferation in the epidermis of the sea anemone Aiptasia pallida
Fransolet, David ULg; Roberty, Stéphane ULg; Plumier, Jean-Christophe ULg

in Marine Biology (2014)

Corals exposed to environmental stresses need to engage appropriate physiological strategies to survive. Here we examined tissue modifications following algal dysfunction. Aiptasia pallida was exposed ... [more ▼]

Corals exposed to environmental stresses need to engage appropriate physiological strategies to survive. Here we examined tissue modifications following algal dysfunction. Aiptasia pallida was exposed during one week to 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), the herbicide called Diuron. DCMU treatment produced a drastic loss in photosynthetic efficiency and a subsequent diminution of algae density over the following days. Cell proliferation evaluated by measuring the number of cells labeled with a thymidine analogue (EdU) revealed a significant increase in EdU+ cells in the epidermis after one week of DCMU incubation and in the gastrodermis at four weeks. TUNEL histology showed that the extent of cell death was however similar in the epidermis of control and treated specimens. In addition we noticed a significant effect of DCMU treatment on the density of epidermal mucocytes after one, two and four weeks. These results show that inhibition of Symbiodinium photosynthesis in the absence of any known direct effect of DCMU on host cells can induce an increase of epidermal host cell proliferation in both the epidermis and the gastrodermis. While new host gastrodermal cells are likely to promote tissue regeneration in order to recruit new algae, the new host epidermal cells may contribute to tissue adaptation following a decrease in energy income. Some of these new epidermal cells, such as mucocytes, may contribute to an eventual increase of the host heterotrophic ability until restoration of algal autotrophic contribution. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailA Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish
Genon, Sarah ULg; Bastin, Christine ULg; Angel, Lucie et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 54

Detailed reference viewed: 61 (12 ULg)
Full Text
Peer Reviewed
See detailExperimental parametric study and design of Piano Key Weirs
Machiels, Olivier; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Research (2014)

Piano Key Weirs are an effective solution for dam rehabilitation as well as new dam projects with a high level of hydraulic constraints. In order to improve the efficiency of their design, an experimental ... [more ▼]

Piano Key Weirs are an effective solution for dam rehabilitation as well as new dam projects with a high level of hydraulic constraints. In order to improve the efficiency of their design, an experimental study of the influence of the main geometric parameters has been performed. Thirty one configurations were tested for a wide range of discharges. The results of the study show the influence of the weir height, the keys widths and the overhangs lengths on the discharge capacity and flow characteristics. Based on hydraulic considerations, optimum values of the main geometric ratios are provided. An analytical formulation is developed to predict the discharge capacity of the weir as a function of its geometry. It shows an accuracy of 10% compared to the experimental results of this study and from other sources. [less ▲]

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailInfluence and interaction indexes for pseudo-Boolean functions: a unified least squares approach
Marichal, Jean-Luc; Mathonet, Pierre ULg

in Discrete Applied Mathematics (2014), 179

The Banzhaf power and interaction indexes for a pseudo-Boolean function (or a cooperative game) appear naturally as leading coefficients in the stan- dard least squares approximation of the function by a ... [more ▼]

The Banzhaf power and interaction indexes for a pseudo-Boolean function (or a cooperative game) appear naturally as leading coefficients in the stan- dard least squares approximation of the function by a pseudo-Boolean func- tion of a specified degree. We first observe that this property still holds if we consider approximations by pseudo-Boolean functions depending only on specified variables. We then show that the Banzhaf influence index can also be obtained from the latter approximation problem. Considering cer- tain weighted versions of this approximation problem, we introduce a class of weighted Banzhaf influence indexes, analyze their most important properties, and point out similarities between the weighted Banzhaf influence index and the corresponding weighted Banzhaf interaction index. We also discuss the issue of reconstructing a pseudo-Boolean function from prescribed influences and point out very different behaviors in the weighted and non-weighted cases. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailNitroxide mediated polymerization of methacrylates at moderate temperature
Detrembleur, Christophe ULg; Jérôme, Christine ULg; De Winter, Julien et al

in Polymer Chemistry (2014), 5(2), 335-340

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide ... [more ▼]

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide precursor. The combination of a low temperature azo-initiator with a hindered nitroso-compound produces a mixture of hindered nitroxides in the polymerization medium that act as efficient polymerization control agents. Results of Electron Spin Resonance (ESR) spectroscopy experiments combined with mass spectrometric studies support the proposed in situ NMP mechanism. The hindered structure of the nitroxides formed in situ is believed to be responsible for the efficiency of the process by allowing it to proceed at low temperature, therefore limiting the side reactions generally observed in NMP of methacrylates. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailDermatophytes transmis par les animaux domestiques
Monod, M; Fratti, B; Mignon, Bernard ULg et al

in Revue Médicale Suisse (2014), 10

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailLE CYBERKNIFE AIME LES DEFIS ! Aperçu d'indications pour la radiothérapie extracrânienne robotisée
JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 87-93

Toute l’histoire de la radiothérapie illustre la quête continue vers une distribution de dose la plus haute possible sur la cible tumorale, tout en réduisant au maximum l’irra - diation des tissus sains ... [more ▼]

Toute l’histoire de la radiothérapie illustre la quête continue vers une distribution de dose la plus haute possible sur la cible tumorale, tout en réduisant au maximum l’irra - diation des tissus sains. La radiothérapie en conditions stéréo - taxiques est la suite logique de cette évolution tant au niveau de la précision d’exécution du traitement qu’au niveau de la concentration de la dose, et donc de l’efficacité du traitement. Cette technique a d’abord été mise en application clinique pour des lésions intra-crâniennes. Une radiothérapie de haute précision ne peut être sensible aux mouvements incontrôlés de la cible. Vu la nécessité en clinique d’aborder les mêmes concepts de précision et d’efficacité pour des cibles extra-crâ - niennes, il a fallu développer des solutions qui permettent de tenir compte du mouvement de la cible. Les solutions infor - matiques et robotiques ont été combinées dans le concept du CyberKnife ® . Nous présentons cette technique particulière d’irradiation et voulons faire part de l’expérience des deux premières années acquise au CHU de Liège. Nous voulons également revoir les indications potentielles de cette radiothé - rapie de très haute précision [less ▲]

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailBilateral internal thoracic artery use: will another retrospective study ever strengthen the prospect?
Head, Stuart J.; Kappetein, A. Pieter; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2014)

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailAging Reduces the Stimulating Effect of Blue Light on Cognitive Brain Functions
Daneault, Véronique; Hébert, Marc; Albouy, Geneviève et al

in Sleep (2014)

Detailed reference viewed: 30 (1 ULg)
Full Text
Peer Reviewed
See detailInfluence de l'environnement et des pratiques culturales sur la productivité de Jatropha curcas L. en Afrique subsaharienne (synthèse bibliographique)
Minengu, Jean de Dieu; Mobambo, Patrick; Mergeai, Guy ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 290-300

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the ... [more ▼]

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the development of the plants was low and yields during the first years of cultivation were mostly disappointing. The low yields obtained in marginal conditions led to the belief that the cultivation of Jatropha could only be profitable in areas with fertile soils and sufficiently humid climates, which would place the plants in direct competition with food production. This article analyzes the available scientific knowledge regarding the ecological and technical factors influencing the productivity of J. curcas and suggests possible solutions for improving its performance in sub-Saharan Africa. [less ▲]

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailVector-like leptons: Higgs decays and collider phenomenology
Falkowski, A.; Straub, D. M.; Vicente, Avelino ULg

in Journal of High Energy Physics [=JHEP] (2014), 1405

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailFolinic acid treatment for schizophrenia associated with folate receptor autoantibodies.
RAMAEKERS, Vincent ULg; Thony, B.; Sequeira, J. M. et al

in Molecular genetics and metabolism (2014), 113(4), 307-14

BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia ... [more ▼]

BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. Acoustic hallucinations disappeared following folinic acid treatment. Folate transport to the CNS prevents homocysteine accumulation and delivers one-carbon units for methyl-transfer reactions and synthesis of purines. The guanosine derivative tetrahydrobiopterin acts as common co-factor for the enzymes producing dopamine, serotonin and nitric oxide. METHODS: Our study selected patients with schizophrenia unresponsive to conventional treatment. Serum from these patients with normal plasma homocysteine, folate and vitamin B12 was tested for FR autoantibodies of the blocking type on serial samples each week. Spinal fluid was analyzed for MTHF and the metabolites of pterins, dopamine and serotonin. The clinical response to folinic acid treatment was evaluated. RESULTS: Fifteen of 18 patients (83.3%) had positive serum FR auto-antibodies compared to only 1 in 30 controls (3.3%) (chi(2)=21.6; p<0.0001). FRalpha antibody titers in patients fluctuated over time varying between negative and high titers, modulating folate flux to the CNS, which explained low CSF folate values in 6 and normal values in 7 patients. The mean+/-SD for CSF MTHF was diminished compared to previously established controls (t-test: 3.90; p=0.0002). A positive linear correlation existed between CSF MTHF and biopterin levels. CSF dopamine and serotonin metabolites were low or in the lower normal range. Administration of folinic acid (0.3-1mg/kg/day) to 7 participating patients during at least six months resulted in clinical improvement. CONCLUSION: Assessment of FR auto-antibodies in serum is recommended for schizophrenic patients. Clinical negative or positive symptoms are speculated to be influenced by the level and evolution of FRalpha antibody titers which determine folate flux to the brain with up- or down-regulation of brain folate intermediates linked to metabolic processes affecting homocysteine levels, synthesis of tetrahydrobiopterin and neurotransmitters. Folinic acid intervention appears to stabilize the disease process. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailQuand la prévention du burnout passe par le management de proximité.
Hansez, Isabelle ULg; Firket, Pierre ULg

in Archives des Maladies Professionnelles et de l'Environnement (2014), 75(5), 519-519

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailVol vaderlands leven en volksgezind streven: Het Kinkergenootschap te Luik (1886-ca. 1913)
Steyaert, Kris ULg

in Negentiende Eeuw (2014), 38(1), 41-60

The Kinker Association was founded in 1886 for the benefit of the many Dutch-speaking Flemings living and working in francophone Liège. Organizing lectures on a variety of subjects, the Association ... [more ▼]

The Kinker Association was founded in 1886 for the benefit of the many Dutch-speaking Flemings living and working in francophone Liège. Organizing lectures on a variety of subjects, the Association attempted to exert an emancipatory influence. Not only did it set up an extensive Dutch library but it also provided access to medical care and insurance. Above all, the Kinker Association wanted to boost the presence of Dutch-related cultural activities in the city. With its liberal sympathies and close links to the Willems Fonds, the Association met with opposition from various quarters, not least from the Catholic Church. This article looks in detail at the genesis, and rise and fall of the Association, its membership and its place and appeal within the wider socio-cultural context of late-nineteenth-century Wallonia. [less ▲]

Detailed reference viewed: 29 (2 ULg)
Full Text
Peer Reviewed
See detailUne tablette scolaire copte de Lecce : TUL inv. C 1
Carlig, Nathan ULg; Delattre, Alain

in Studi di Egittologia e di Papirologia (2014), 11

Critical edition with commentary of TUL inv. C 1, an unpublished Coptic wooden tablet, kept in the Museo papirologico, Università del Salento (Lecce, Italie).

Detailed reference viewed: 37 (4 ULg)
Full Text
Peer Reviewed
See detailAn open-air site from the recent Middle Palaeolithic in the Paris Basin (France): Les Bossats at Ormesson (Seine-et-Marne).
Bodu, Pierre; Salomon, Hélène ULg; Leroyer, Mathieu et al

in Quaternary International (2014), 331

In northern France, most of the sites attributed to the Middle Palaeolithic are open-air sites in which mainly lithic artefacts are found, due to taphonomic conditions often unfavourable to the ... [more ▼]

In northern France, most of the sites attributed to the Middle Palaeolithic are open-air sites in which mainly lithic artefacts are found, due to taphonomic conditions often unfavourable to the preservation of fauna. The lithic assemblages found in most of those open-air sites suggest that the activities on the camp sites were diversified, although flint knapping was often intense due to the proximity of sources of raw siliceous materials. With the exception of very rare open-air sites, fauna is poorly preserved and spatial and economic analyses may often be based on the spatial distribution of lithic artefacts, in particular based on refits and their analysis. Therefore the palaeoethnological approach is difficult to implement in most open-air areas. In contrast, in the Paris Basin, the study of more recent sites from the Tardiglacial, such as the Magdalenian sites of Pincevent or Etiolles, falls within this approach. The recent discovery (2009) and excavation of the open-air site of Ormesson (Seine-et-Marne - France) was initially intended to document a Gravettian occupation floor dated around 26,000 years uncal BP and related to a preferential bison hunt. Whilst checking the thickness of the loess in which the Gravettian level was found, several other prehistoric settlements were discovered (Chatelperronian, Middle Solutrean) including two units attributed to the Middle Palaeolithic. One of them, level 4, seems to be particularly well-preserved. It occurs between one and three meters below the main Upper Palaeolithic occupation. The lithic industry from level 4 belongs to a technical tradition generally attributed to the Middle Palaeolithic: discoid technology. The freshness of the material and the presence of bone fragments attributed in part to horse support a general good state of preservation of this occupation. The Mousterian remains seem to cover at least 500 m2, as currently estimated. Even more exceptional is the close spatial relationship between the discoid industry, the bone pieces, remains of fireplaces and especially the numerous fragments and nodules of red colouring materials. These were brought to the site where they were utilised by the Mousterians. The used surfaces show indisputable scraping traces and facets. These recent discoveries will certainly contribute to the debate on the cognitive capacities of nearly the last representatives of the Middle Palaeolithic and this within a complex stratigraphy which will allow us to make comparisons between the different periods. [less ▲]

Detailed reference viewed: 114 (4 ULg)
Full Text
Peer Reviewed
See detailMultitasking capacities in persons diagnosed with schizophrenia: A preliminary examination of their neurocognitive underpinnings and ability to predict real world functioning
Laloyaux, Julien ULg; Van der Linden, Martial ULg; Levaux, Marie-Noëlle ULg et al

in Psychiatry Research (2014), 217

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia and in particular during multitasking activities. However, at present, patients' multitasking capacities ... [more ▼]

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia and in particular during multitasking activities. However, at present, patients' multitasking capacities have not been adequately examined in the literature due to an absence of suitable assessment strategies. We thus recently developed a computerized real-life activity task designed to take into account the complex and multitasking nature of certain everyday life activities where participants are required to prepare a room for a meeting. Twenty-one individuals diagnosed with schizophrenia and 20 matched healthy controls completed the computerized task. Patients were also evaluated with a cognitive battery, measures of symptomatology and real world functioning. To examine the ecological validity, 14 other patients were recruited and were given the computerized version and a real version of the meeting preparation task. Results showed that performance on the computerized task was significantly correlated with executive functioning, pointing to the major implication of these cognitive processes in multitasking situations. Performance on the computerized task also significantly predicted up to 50% of real world functioning. Moreover, the computerized task demonstrated good ecological validity. These findings suggest the importance of evaluating multitasking capacities in patients diagnosed with schizophrenia in order to predict real world functioning. [less ▲]

Detailed reference viewed: 25 (7 ULg)
Full Text
See detailGermanistik und Sprachlandschaft in Belgien
Küpper, Achim ULg

in Newsletter des Deutschen Germanistenverbands (2014), (1), 14-16

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailBiologie de la reproductiond'un poissonchat africain Euchiloichthys guentheri (Schilthuis, 1891)(Mochokidae, Siluriformes) au Pool Malebo, Fleuve Congo (République démocratique du CongoR
Tembeni, John; Micha, jean-Claude; Mbomba, B.N.S. et al

in Tropicultura (2014), 32

In the Malebo Pool of the Congo River in DRC, Euchilichthys guentheri (Schilthuis, 1891) a highly consumed fish during the dry season, undergoes a strong pressure of fishing whereas one does not have ... [more ▼]

In the Malebo Pool of the Congo River in DRC, Euchilichthys guentheri (Schilthuis, 1891) a highly consumed fish during the dry season, undergoes a strong pressure of fishing whereas one does not have knowledge on his reproductive biology. Reproductive parameters of E. guentheri were determined to ensure rational and sustainable management of the resource at Malebo Pool. Fish were collected monthly between January and December 2009, and subsequently from February to December 2011. The whole sample consisted of 248 specimens of which 35 immature, 118 females and 95 males were examined. The observed sex- ratio was balanced between males and females (1:0.99; χ2=12; p>0.05). The standard length at first sexual maturity was 54.20 cm for males, and 54.49 cm for females. The spawning period of E. guentheri was established by analyzing the temporal evolution in the monthly variations of the gonado-somatic index (GSI). E. guentheri in Malebo Pool spawns in the end of the dry season but the main breeding season was August and September. The ripe ovaries contained 1953 to 7256 eggs. The relative fecundity was 1745±582 eggs.kg-1 of females. The mean oocyte diameter was 2.12±0.39 mm at spawning. These reproduction characteristics of E. guentheri make it possible to classify this fish among the species with big eggs and low fecundity. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detailAuditory hallucinations in persons with and without a need for care
Johns; Kompus, K; Connell, M et al

in Schizophrenia Bulletin (2014), 40

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailSarapis et Neôtera élus parmi les dieux
Veymiers, Richard ULg

in Revue Archéologique (2014), (1), 37-56

One of the bronze plates formerly in the Bianchini collection, which entered the Cabinet des Médailles (Paris) at the end of the 18th century, bears a text and an image, supposedly unintelligible and ... [more ▼]

One of the bronze plates formerly in the Bianchini collection, which entered the Cabinet des Médailles (Paris) at the end of the 18th century, bears a text and an image, supposedly unintelligible and therefore thought to be of a magic nature. A new examination of this artefact, actually the main part of a bracelet, shows that it depicts an assembly of twenty-eight divinities, illustrating the religious landscape of Egypt in the 2nd-3rd century, and that it is inscribed with two short acclamations. The first one exalts the greatness of the name of Sarapis, the second that of Neôtera the invincible. The identity of this goddess is difficult to define, but she often seems to correspond to a form of Isis assimilated to Korè. The glorifying invocation of these two gods, depicted with their pantheon, may be considered to be an expression of what is today called “megatheism”. [less ▲]

Detailed reference viewed: 71 (0 ULg)
Full Text
Peer Reviewed
See detailL'inhibition des voies de signalisation est-elle une possibilité thérapeutique pour l'arthrose?
Henrotin, Yves ULg

in Revue du Rhumatisme (2014)

Les voies de signalisation sont des cibles intéressantes pour les traitements de l’arthrose car leur inhibition ou leur activation permet de réguler l’expression d’un ensemble de gènes cibles directement ... [more ▼]

Les voies de signalisation sont des cibles intéressantes pour les traitements de l’arthrose car leur inhibition ou leur activation permet de réguler l’expression d’un ensemble de gènes cibles directement impliqués dans le dysfonctionnement métabolique des tissus articulaires. Cependant, les premiers essais cliniques réalisés dans la PR ont montré que la régulation spécifique de la voie JAK/STAT induit de nombreux effets secondaires. Ce point pourrait être un facteur limitant l’utilisation d’inhibiteurs ou d’activateurs spécifiques des voies de signalisation dans l’arthrose. Dans cette maladie, le rapport risque/bénéfice doit rester le facteur clé de la décision thérapeutique, car il s’agit de traiter une maladie d’évolution lente, de sévérité modérée et associée à de nombreuses comorbidités. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailThe threshold photoelectron spectroscopy of the cis- and trans-1-chloro-2-fluoro-ethene isomers. An experimental and quantum chemical study.
Locht, Robert ULg; Dehareng, Dominique ULg; Leyh, Bernard ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (2014), 47(17), 175101-175012

The threshold photoelectron spectra (TPES) of the two vicinal isomers of the 1,2-C2H2FCl molecule have been investigated in the 9-24 eV energy range using synchrotron radiation. Eight (for the cis-isomer ... [more ▼]

The threshold photoelectron spectra (TPES) of the two vicinal isomers of the 1,2-C2H2FCl molecule have been investigated in the 9-24 eV energy range using synchrotron radiation. Eight (for the cis-isomer) or nine (for the trans-isomer) bands have been observed and the corresponding ionization energies have been determined. The spectroscopic assignments are based on high level quantum chemical ab initio calculations for both isomers. Most of the observed spectral features could be interpreted. For both species the first three TPES bands exhibit a rich vibrational structure. Vibrational energies were determined and assignments were also supported by quantum chemical calculations of vibrational wavenumbers for these three ionic states of both isomers. [less ▲]

Detailed reference viewed: 33 (12 ULg)
Full Text
Peer Reviewed
See detailAntioxidant Activity of Compounds Isolated from the Root Woods of Erythrina droogmansiana
Yaya, AJG; Feumba, RD; Emmanuel, T et al

in International Journal of Pharmaceutical Sciences and Drug Research (2014), 6(2), 160-163

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract ... [more ▼]

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract and isolated compounds. The phytochemical study led to the isolation of 3-(3’,4’-methelenedioxyphenyl)-2,3-epoxypropanol (1), asperphenamate (2) and three flavonoids namely genistein, diadzein and 4’,5,7-trihydroxy-8-prenylisoflavone. These compounds were characterized using their 1H NMR, 13C NMR, HMBC, HSQC, COSY, mass spectral and the literature. To evaluate antioxidant activity of crude extract and isolated compounds, the radical scavenging (DPPH) and Ferric Reducing Ability Power (FRAP) were performed using ascorbic acid as standard. Compounds 1 and 2 showed moderate radical scavenging potential with IC50 value of 3.14 and 3.31 mg/ml respectively, and moderate reducing power ability with value of 0.14±0.01 mgAAE/mg and 0.21±0.01 mgAAE/mg respectively. The more active compound was genistein (3) with IC50 value of 1.96 mg/ml for the DPPH radical scavenging potential and 0.24±0.02 mgAAE/mg for its ability to reduce iron. [less ▲]

Detailed reference viewed: 25 (5 ULg)
Full Text
Peer Reviewed
See detailSoil contamination near a former Zn-Pb ore-treatment plant: Evaluation of deterministic factors and spatial structures at the landscape scale
Liénard, Amandine ULg; Brostaux, Yves ULg; Colinet, Gilles ULg

in Journal of Geochemical Exploration (2014), 147

Historical soil contamination within a 3 km radius of a former ore treatment plant was evaluated. A total of 247 topsoil samples were collected in a stratified random sampling design taking into account ... [more ▼]

Historical soil contamination within a 3 km radius of a former ore treatment plant was evaluated. A total of 247 topsoil samples were collected in a stratified random sampling design taking into account three factors: land use (LU), soil type (ST) and wind direction (WD). Concentrations of trace elements (Cd, Co, Cr, Cu, Ni, Pb and Zn) and major elements (Ca, Mg, K, Fe, Al, Mn) as well as various soil properties (pHwater, pHKCl, TOC and N) were measured. Total Cd, Pb and Zn concentrations were higher than typical background values. Enrichment factors for these three metals were, respectively, 260, 77.4 and 35.5. Principal components analysis (PCA) and factor analysis segregated anthropogenic contamination as a premier factor in influencing concentrations, followed by a second lithogenic factor. The anthropogenic origin of substantial contamination was confirmed though mapping of sample locations relative to contaminant sources. Factor 1 (26.5% of the variance) impacts a large area around the contaminated site and is also indicative of WD influence. Factor 2 (23.9% of the variance) is naturally linked to the local lithology and geology. LU and soil fertility are, respectively, represented by factor 3 (16.5% of the variance), which is linked to pH, and factor 4 (9.3% of the variance), related to organic content. The significance of landscape factors in the spatial distribution of metallic trace elements (MTE) was assessed with an ANCOVA using “distance to the source” as a covariate. Results of the analysis support the hypothesis that Cd, Cu, Pb and Zn concentrations are mainly driven by anthropogenic factors, specifically historical industrial activity at the former ore treatment plant. The ANCOVA also provides a means to quantify the impact of LU and ST as well, particularly on MTE availability in soils. The presence of MTE in soil poses known, and potentially significant, risks to both human health and the environment. [less ▲]

Detailed reference viewed: 42 (7 ULg)
Full Text
Peer Reviewed
See detailSpatial patterns and morphology of termite ( Macrotermes falciger ) mounds in the Upper Katanga, D.R. Congo
Mujinjya, Baile Baziraké; Adam, Marielle; Mees, Florias et al

in Catena (2014), 114

This study examines the spatial distribution patterns and morphological characteristics of Macrotermes falciger mounds in the peri-urban zone of Lubumbashi, D.R. Congo. Spatial patterns of mounds were ... [more ▼]

This study examines the spatial distribution patterns and morphological characteristics of Macrotermes falciger mounds in the peri-urban zone of Lubumbashi, D.R. Congo. Spatial patterns of mounds were assessed using high-resolution satellite images for 24 plots of variable size (3 to 27 ha). Soil morphological features were described for five termite-mound profiles of 5 to 9 m depth/height. A mean areal number density of 2.9 ± 0.4 mounds ha−1 is estimated for the degraded miombo woodland of the study area. Spatial statistical analyses document that termite mounds are regularly distributed in all studied plots. The overall mean nearest-neighbour distance between termite mounds is 44.6 ± 0.6 m. The high relative number of inactive mounds in the region, with regular distribution patterns, suggests that current termite mound occurrences are largely relict features.There are no clear indications for an impact of the nature of the parent material on the spatial distribution of the mounds. One aspect of differences in morphology between the studied mounds is that the stone layer occurs at greater depth in topographic low areas than at crest and slope positions. This is interpreted as being mainlyconditionedbyerosion.Mn–Fe oxideconcentrationsoccurringinallstudiedtermite moundprofiles reflect a seasonally high perched water table beneath the mound, which is more pronounced at lower landscape positions. In summary, mound positions in the habitat are consistent with intraspecific competition rather than soil and substrate characteristics as controlling factor, whereas variation in morphological characteristics between termite-mound profiles appears to be a function of the parent material [less ▲]

Detailed reference viewed: 66 (13 ULg)
Full Text
Peer Reviewed
See detailThe political choices of emigrants voting in home country elections: A socio-political analysis of the electoral behaviour of Bolivian external voters
Lafleur, Jean-Michel ULg; Sanchez-Dominguez, Maria

in Migration Studies (2014)

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this ... [more ▼]

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this question remains largely unanswered. Basing ourselves on the existing political science literature on electoral behaviour and on the migration literature on immigrants’ participation in host country politics, we isolate different hypotheses that explain emigrants’ preferences in home country politics. We then build four models of voters based on these hypotheses: the social group voter, the ideological voter, the interest-driven voter, and the transnational voter. In the second part of the paper, we verify the validity of these models using the results of a survey carried out with Bolivian emigrants who took part in the 2009 Bolivian presidential election from abroad. Overall, this article identifies the drivers of immigrant transnational political participation and contributes to current debates on social remittances. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailUse of azathioprine in IBD: modern aspects of an old drug.
Louis, Edouard ULg; Irving, Peter; Beaugerie, Laurent

in Gut (2014), 63(11), 1695-9

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailGouvy/Bovigny : empierrement à Courtil "Obourcy"
Drailly, Christelle; Thiebaux, Aurélie ULg; Goemaere, Eric

in Chronique de l'Archéologie Wallonne (2014), 21

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailPrésentation
Caeymaex, Florence ULg; Cormann, Grégory ULg

in Etudes Sartriennes (2014), 17

Detailed reference viewed: 32 (7 ULg)
Full Text
Peer Reviewed
See detailA Systematic Scoping Study of the Socio-Economic Impact of Rift Valley Fever: Research Gaps and Needs
Peyre, Marisa; Chevalier, Véronique; Abdo-Salem, Shaif et al

in Zoonoses and Public Health (2014)

Rift Valley fever (RVF) is a severe mosquito-borne disease affecting humans and domestic ruminants. RVF virus has been reported in most African countries, as well as in the Arabic Peninsula. This paper ... [more ▼]

Rift Valley fever (RVF) is a severe mosquito-borne disease affecting humans and domestic ruminants. RVF virus has been reported in most African countries, as well as in the Arabic Peninsula. This paper reviews the different types of socio-eco- nomic impact induced by RVF disease and the attempts to evaluate them. Of the 52 papers selected for this review, 13 types of socio-economic impact were identi- fied according to the sector impacted, the level and temporal scale of the impact. RVF has a dramatic impact on producers and livestock industries, affecting public and animal health, food security and the livelihood of the pastoralist communities. RVF also has an impact on international trade and other agro-industries. The risk of introducing RVF into disease-free countries via the importation of an infected animal or mosquito is real, and the consequent restriction of access to export mar- kets may induce dramatic economic consequences for national and local econo- mies. Despite the important threat of RVF, few studies have been conducted to assess the socio-economic impact of the disease. The 17 studies identified for quantitative analysis in this review relied only on partial cost analysis, with limited reference to mid- and long-term impact, public health or risk mitigation mea- sures. However, the estimated impacts were high (ranging from $5 to $470 mil- lion USD losses). To reduce the impact of RVF, early detection and rapid response should be implemented. Comprehensive disease impact studies are required to provide decision-makers with science-based information on the best intervention measure to implement ensuring efficient resource allocation. Through the analysis of RVF socio-economic impact, this scoping study proposes insights into the mechanisms underpinning its often-underestimated importance. This study high- lights the need for comparative socio-economic studies to help decision-makers with their choices related to RVF disease management. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailOn the pragmatics of subjectification: The grammaticalization of verbless allative futures (with a case study in Ancient Egyptian)
Grossman, Eitan; Polis, Stéphane ULg

in Acta Linguistica Hafniensia : International Journal of Linguistics (2014), 46(1), 25-63

In this paper, we argue that an expanded conception of the distinction between speaker-oriented and subject-oriented inferences is crucial for understanding the motivations and mechanisms of semantic ... [more ▼]

In this paper, we argue that an expanded conception of the distinction between speaker-oriented and subject-oriented inferences is crucial for understanding the motivations and mechanisms of semantic change in grammaticalization and subjectification, on the one hand, and for clarifying the links between semantic change and reductive formal changes, on the other. Speaker-oriented inferences have significant consequences, leading to the relaxation of selectional restrictions on a construction. In turn, the relaxation of selectional restrictions can create conditions in which the type and token frequency of a construction can rise considerably. Furthermore, changes in the selectional restrictions on a construction can themselves catalyze semantic change by coercing listeners into new form–function pairings. This framework is applied to allative futures, a typological comparative concept developed in order to compare structurally diverse future tenses. Following the typological discussion, a diachronic case study of the emergence and grammaticalization of a verbless allative future in Ancient Egyptian is presented. Such verbless allative futures provide evidence against assumptions that purpose constructions as such are not grammaticalized as future tense constructions (Schmidtke-Bode 2009). Rather, they corroborate earlier hypotheses that it is the allative component of source constructions that crucially leads to intention meanings, and from intention to prediction (see, e.g., Bybee, Pagliuca, and Perkins 1994). [less ▲]

Detailed reference viewed: 123 (18 ULg)
Full Text
Peer Reviewed
See detailWhen the value of gold is zero.
Chase, J. Geoffrey; Moeller, Knut; Shaw, Geoffrey M. et al

in BMC research notes (2014), 7

This manuscript presents the concerns around the increasingly common problem of not having readily available or useful "gold standard" measurements. This issue is particularly important in critical care ... [more ▼]

This manuscript presents the concerns around the increasingly common problem of not having readily available or useful "gold standard" measurements. This issue is particularly important in critical care where many measurements used in decision making are surrogates of what we would truly wish to use. However, the question is broad, important and applicable in many other areas.In particular, a gold standard measurement often exists, but is not clinically (or ethically in some cases) feasible. The question is how does one even begin to develop new measurements or surrogates if one has no gold standard to compare with?We raise this issue concisely with a specific example from mechanical ventilation, a core bread and butter therapy in critical care that is also a leading cause of length of stay and cost of care. Our proposed solution centers around a hierarchical validation approach that we believe would ameliorate ethics issues around radiation exposure that make current gold standard measures clinically infeasible, and thus provide a pathway to create a (new) gold standard. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailSkin viscoelasticity in incipient gravitational syndrome.
Pierard, Gérald ULg; Paquet, Philippe; Pierard-Franchimont, Claudine ULg

in Journal of cosmetic dermatology (2014), 13(1), 52-5

BACKGROUND: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are ... [more ▼]

BACKGROUND: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are altered. AIMS: To assess incipient gravitational edema due to chronic venous insufficiency using measurements of the skin tensile strength. METHOD: A total of 21 women aged 28-37 years were enrolled in the study. Evaluations were made twice in each subject following an alternate use and avoidance of daytime elastic contention. Skin viscoelasticity was measured on the mid portion of the calves using a computerized suction device. RESULTS: The discretely increased consistency of skin showing abnormal rheological characteristics at the site of incipient gravitational edema was significantly improved by contention therapy. Under progressive suction measurements, both skin distensibility, biologic elasticity and hysteresis were increased after wearing tight stockings. The biologic elasticity appears to be the most sensitive parameter pointing to the diagnosis of gravitational syndrome. CONCLUSION: Noninvasive measurements of the skin viscoelasticity, particularly the biologic elasticity, represent an objective assessment of both early gravitational edema and its control by contention therapy. [less ▲]

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailWhich incretin-based therapy for type 2 diabetes?
Scheen, André ULg

in Lancet (2014)

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailAsymmetric facial skin viscoelasticity during climacteric aging.
Pierard, Gérald ULg; Hermanns-Lê, Trinh ULg; Gaspard, Ulysse ULg et al

in Clinical, cosmetic and investigational dermatology (2014), 7

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the ... [more ▼]

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the aging process. METHODS: Skin viscoelasticity was compared on both cheeks in premenopausal and post-menopausal women with indoor occupational activities somewhat limiting the influence of chronic sun exposure. Eighty-four healthy women comprising 36 premenopausal women and 48 early post-menopausal women off hormone replacement therapy were enrolled in two groups. The tensile characteristics of both cheeks were tested and compared in each group. A computerized suction device equipped with a 2 mm diameter hollow probe was used to derive viscoelasticity parameters during a five-cycle procedure of 2 seconds each. Skin unfolding, intrinsic distensibility, biological elasticity, and creep extension were measured. RESULTS: Both biological elasticity and creep extension were asymmetric on the cheeks of the post-menopausal women. In contrast, these differences were more discrete in the premenopausal women. CONCLUSION: Facial skin viscoelasticity appeared to be asymmetric following menopause. The possibility of asymmetry should be taken into account in future studies of the effects of hormone replacement therapy and any antiaging procedure on the face in menopausal women. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailL'électroneuromyographie dans la pathologie de la face dorsale du pied
WANG, François-Charles ULg

in Médecine et Chirurgie du Pied = Foot Medicine and Surgery (2014), (30), 86-89

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailLa présence isiaque dans le Péloponnèse. Sur les traces des lieux de culte
Veymiers, Richard ULg

in Revue archéologique. Bulletin de la Société française d'archéologie classique (SFAC). (2014), 1

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailThe evaluation of vocal pitch accuracy: The case of operatic singing voices
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Music Perception (2014), 32(1), 1-10

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices ... [more ▼]

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices, which have particularly complex acoustical signals. Twenty-two music experts were asked to evaluate the vocal pitch accuracy of 14 sung performances with a pairwise comparison paradigm, in a test and a retest. In addition to the objective measurement of pitch accuracy (pitch interval deviation), several performance parameters (average tempo, fundamental frequency of the starting note) and quality parameters (energy distribution, vibrato rate and extent) were observed and compared to the judges’ perceptual rating. The results show high intra- and inter-judge reliability when rating the pitch accuracy of operatic singing voices. Surprisingly, all the parameters were significantly related to the ratings and explain 78.8% of the variability of the judges’ rating. The pitch accuracy evaluation of operatic voices is thus not based exclusively on the precision of performed music intervals but on a complex combination of performance and quality parameters. [less ▲]

Detailed reference viewed: 40 (15 ULg)
Full Text
Peer Reviewed
See detailAlgebrability and nowhere Gevrey differentiability
Bastin, Françoise ULg; Conejero, J. Alberto; Esser, Céline ULg et al

in Israel Journal of Mathematics (2014)

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and ... [more ▼]

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and, therefore, lineability) of functions enjoying this property. In the process of proving these results we also provide a new construction of nowhere Gevrey di fferentiable functions. [less ▲]

Detailed reference viewed: 83 (33 ULg)
Full Text
Peer Reviewed
See detailLa vignette diagnostique de l'etudiant. Diagnostic et evaluation d'une hypoglycemie chez le patient diabetique.
Scheen, André ULg

in Revue medicale de Liege (2014), 69(2), 110-5

Hypoglycaemic episodes are rather common among diabetic patients, especially those treated with sulfonylureas or insulin (more in type 1 than in type 2 diabetes). The presentation of hypoglycaemia may ... [more ▼]

Hypoglycaemic episodes are rather common among diabetic patients, especially those treated with sulfonylureas or insulin (more in type 1 than in type 2 diabetes). The presentation of hypoglycaemia may considerably vary from patient-to-patient and from time-to-time in a given patient. With the illustration of a clinical case, we will describe the characteristics of the three main types of hypoglycaemia: severe hypoglycaemia (with or without coma), symptomatic hypoglycaemia (with or without confirmation) and asymptomatic hypoglycaemia ("hypoglycaemia unawareness") discovered as a low blood glucose measurement. We will also briefly analyse the reasons of such differences and the potential clinical consequences that these three main types of hypoglycaemia may exert in the real life of diabetic patients. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailÉvaluation du potentiel de dix accessions de Jatropha curcas L. (Euphorbiaceae) au Niger
Abdoul Habou, Zakari; Katkore, Boubacar; Abasse, Tougiani et al

in Journal of Applied Biosciences (2014), 77

Objective: A trial of the ten accessions for J curcas was carried out at regional Agricultural Research Center of Maradi in Niger, with aim to evaluate the performance of Jatropha curcas accessions ... [more ▼]

Objective: A trial of the ten accessions for J curcas was carried out at regional Agricultural Research Center of Maradi in Niger, with aim to evaluate the performance of Jatropha curcas accessions. Methodology and results: Each accession was represented by two rows and each row has 15 plant trees of J. curcas. Data on the rate of survival and growth parameters of each tree were collected. Results revealed that there is no significant difference between accessions tested for height and diameter. Accessions Katil 13 and GB 14 respectively originated from Mali and Bisseau Guinea were best adapted for the Niger conditions. The yield value of 511 and 445 kg per hectare respectively obtained from Katil 13 and GB 14 in 2012.Conclusion and application of results: The Government of Niger has drawn attention to this crop and has launched a J. curcas plantation for seed production of 150 ha at Guessalbodi. National Research Institution. NGOs are also involved in J. curcas plantation for biofuel use. [less ▲]

Detailed reference viewed: 27 (2 ULg)
Full Text
Peer Reviewed
See detailSpatial Planning as a driver of change in mobility and residential energy consumption
Dujardin, Sébastien; Marique, Anne-Françoise ULg; Teller, Jacques ULg

in Energy & Buildings (2014), 68

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning ... [more ▼]

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning decisions upon energy consumption in both residential building stock and home-to-work commuting. The analysis has been conducted on a regional scale (16,844 km2) and includes urban, peri-urban and rural settlements. Those settlements that perform well in mobility also appear to perform well in terms of building energy consumption. Even though this is not generally the case, it further reveals that some rural settlements characterized by low density show good performance in terms of energy efficiency. This permits a much more progressive approach in terms of spatial planning, whereby compact cities may be viewed as part of the solution, albeit not the whole solution. [less ▲]

Detailed reference viewed: 148 (69 ULg)
Full Text
Peer Reviewed
See detailAccuracy of asymptotic standard errors of the maximum and weighted likelihood estimators of proficiency levels with short tests
Magis, David ULg

in Applied Psychological Measurement (2014), 38

The maximum likelihood (ML) and the weighted likelihood (WL) estimators are commonly used to obtain proficiency level estimates with pre-calibrated item parameters. Both estimators have the same ... [more ▼]

The maximum likelihood (ML) and the weighted likelihood (WL) estimators are commonly used to obtain proficiency level estimates with pre-calibrated item parameters. Both estimators have the same asymptotic standard error (ASE) that can be easily derived from the expected information function of the test. However, the accuracy of this asymptotic formula is uncertain with short tests when only a few items are administered. The purpose of this paper is to compare the ASE of these estimators to their exact values, evaluated at the proficiency level estimates. The exact SE is computed by generating the full exact sample distribution of the estimators, so its practical feasibility is limited to small tests (except under the Rasch model). A simulation study was conducted to compare the ASE and the exact SE of the ML and WL estimators, to the “true” SE (i.e., computed as the exact SE with the true proficiency levels). It is concluded that with small tests, the exact SEs are less biased and return smaller root mean squared error values than the asymptotic SEs, while as expected the two estimators return similar results with longer tests. [less ▲]

Detailed reference viewed: 27 (5 ULg)
Full Text
Peer Reviewed
See detailMesozoic marine reptile palaeobiogeography in response to drifting plates
Bardet, Nathalie; Falconnet, Jocelyn; Fischer, Valentin ULg et al

in Gondwana Research (2014)

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically ... [more ▼]

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically, and most were the largest top-predators of the marine ecosystems of their time. The main groups were Ichthyosauria, Sauropterygia, Thalattosauria, and several lineages of Testudinata, Crocodyliformes, Rhynchocephalia and Squamata. Here we show that the palaeobiogeographical distribution of these marine reptiles closely followed the break-up of the supercontinent Pangaea and that they globally used the main marine corridors created by this break-up to disperse. Most Mesozoic marine reptile clades exhibit a cosmopolitan, or at least pandemic, distribution very early in their evolutionary history. The acquisition of morphological adaptations to a fully aquatic life, combined to special thermophysiological characteristics, are probably responsible for these animals to become efficient long-distance open-marine cruisers. Generally, Early Triassic taxa were near-shore animals mainly linked to the Tethys or Panthalassa coastlines. By the end of the Triassic and during the Jurassic, the break-up of Pangaea resulted in the formation of large marine corridors connecting the Tethys to the North Atlantic and Pacific realms, a trend increasing on during the Cretaceous with the expansion of the Atlantic Ocean and the break-up of the southern Gondwana, allowing open-sea marine reptiles to spread out over large distances. However, if large faunal interchanges were possible at a global scale following a dispersal model, some provinces, such as the Mediterranean Tethys, were characterized by a peculiar faunal identity, illustrating an absence of migration with time despite the apparent lack of barriers. So, if Continental Drift enabled global circulations and faunal interchanges via dispersals among Mesozoic marine reptiles, others parameters, such as ecological and biological constraints, probably also played a role in the local endemic distribution of some of these marine groups, as they do today. [less ▲]

Detailed reference viewed: 110 (4 ULg)