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See detailBiophysical characterization data of the artificial protein Octarellin V.1 and binding test with its X-ray helpers.
Figueroa Yévenes, Maximiliano ULg; Vandenameele, Julie ULg; Goormaghtigh, Erik et al

in Data in Brief (2016), 8

The artificial protein Octarellin V.1 (http://dx.doi.org/10.1016/j.jsb.2016.05.004[1]) was obtained through a direct evolution process over the de novo designed Octarellin V (http://dx.doi.org/10.1016 ... [more ▼]

The artificial protein Octarellin V.1 (http://dx.doi.org/10.1016/j.jsb.2016.05.004[1]) was obtained through a direct evolution process over the de novo designed Octarellin V (http://dx.doi.org/10.1016/S0022-2836(02)01206-8[2]). The protein has been characterized by circular dichroism and fluorescence techniques, in order to obtain data related to its thermo and chemical stability. Moreover, the data for the secondary structure content studied by circular dichroism and infra red techniques is reported for the Octarellin V and V.1. Two crystallization helpers, nanobodies (http://dx.doi.org/10.1038/nprot.2014.039[3]) and alphaRep (http://dx.doi.org/10.1016/j.jmb.2010.09.048[4]), have been used to create stable complexes. Here we present the data obtained of the binding characterization of the Octarellin V.1 with the crystallization helpers by isothermal titration calorimetry. [less ▲]

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See detailIdentifying the factors determining blooms of cyanobacteria in a set of shallow lakes
Descy, Jean-Pierre; Leprieur, Fabien; Pirlot, Samuel et al

in Ecological Informatics (2016), 34

There is a strong interest in developing a capacity to predict the occurrence of cyanobacteria blooms in lakes and to identify the measures to be taken to reduce water quality problems associated with the ... [more ▼]

There is a strong interest in developing a capacity to predict the occurrence of cyanobacteria blooms in lakes and to identify the measures to be taken to reduce water quality problems associated with the occurrence of potentially harmful taxa. Here we conducted a weekly to bi-weekly monitoring program on five shallow eutrophic lakes during two years, with the aim of gathering data on total cyanobacterial abundance, as estimated from marker pigments determined by HPLC analysis of phytoplankton extracts. We also determined bloom composition and measured weather and limnological variables. The most frequently identified taxa were Aphanizomenon flos-aquae, Microcystis aeruginosa, Planktothrix agardhii and Anabaena spp. We used the data base composed of a total of 306 observations and an adaptive regression trees method, the boosted regression tree (BRT), to develop predictive models of bloom occurrence and composition, based on environmental conditions. Data processing with BRT enabled the design of satisfactory prediction models of cyanobacterial abundance and of the occurrence of the main taxa. Phosphorus (total and soluble reactive phosphate), dissolved inorganic nitrogen, epilimnion temperature, photoperiod and euphotic depth were among the best predictive variables, contributing for at least 10 % in the models, and their relative contribution varied in accordance with the ecological traits of the taxa considered. Meteorological factors (wind, rainfall, surface irradiance) had a significant role in species selection. Such results may contribute to designing measures for bloom management in shallow lakes. [less ▲]

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See detailL’enfant, l’institutrice et le tableau interactif : Corps relationnel et évolution numérique
Jadin, Aurore ULg; Englebert, Jérôme ULg

in Cahiers de Psychologie Clinique (2016), 46

In clinical psychology, the ecological observation of child in different life domains offers many inaccessible observations through the individual therapy sessions. The article proposes, from a clinical ... [more ▼]

In clinical psychology, the ecological observation of child in different life domains offers many inaccessible observations through the individual therapy sessions. The article proposes, from a clinical case, a reflection on the technological change of classes, particularly through the use of the interactive whiteboard, and the psychological and relational consequences of this revolution, for each of the protagonists. A consequence of this use of the digital device is that the body can appear less necessary and therefore be abandoned in favor of a poorly invested technicality. Our analysis values the development of a necessary compromise between digital and body. It proposes to find ways of arranging so that teacher's body is still a fundamental dimension of the educational process. [less ▲]

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See detailEscribir el presente histórico mexicano: narrar desde narcolandia
Vanden Berghe, Kristine ULg

in Studi Ispanici (2016), XLI

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See detailThe Changing Landscape of Smoldering Multiple Myeloma: A European Perspective
CAERS, Jo ULg; de Larrea, Carlos; Leleu, Xavier et al

in Oncologist (2016), 21

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating ... [more ▼]

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with highrisk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention, although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group asMM, and thus will require optimalMMtreatment, based on biomarkers that identify patients with a.80% risk of progression. The number of these redefined patients is small (∼10%), but important to unravel, because their risk of progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-highrisk SMM are now considered as MMand may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation needs to be undertaken. For the greater majority ofSMMpatients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. [less ▲]

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See detailShear Response of Prestressed Thin-Webbed Continuous Girders
Collins, Michael; Xie, Liping; Mihaylov, Boyan ULg et al

in ACI Structural Journal (2016)

While different design codes provide similar guidance for the flexural design of prestressed thin: webbed continuous girders, the shear design provisions differ greatly. This paper investigates these ... [more ▼]

While different design codes provide similar guidance for the flexural design of prestressed thin: webbed continuous girders, the shear design provisions differ greatly. This paper investigates these discrepancies with the help of eleven experiments and a number of analytical studies. Together these provide the basis for recommendations for engineers conducting the shear design for new girders or evaluating the shear capacity of existing girders. It is shown that the traditional ACI approach of taking Vc as the smaller of Vci, flexural:shear cracking load, and Vcw, web:shear cracking load, can significantly overestimate the shear strength of such girders particularly if they are highly prestressed and contain relatively small quantities of shear reinforcement. The other codes evaluated provided more conservative predictions. It is shown that the ACI predictions can be improved significantly by taking into account the effect of flexural stresses on web shear cracking. While the ACI code uses different shear strength equations for members subjected to external axial loads versus members subjected to internal prestressing forces, the studies summarized in this paper support the idea that unification of these ACI shear provisions is possible. [less ▲]

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See detailGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa et al

in Autophagy (2016), 12(1), 1-222

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See detailCalcific aortic stenosis.
Lindman, Brian R.; Clavel, Marie-Annick; Mathieu, Patrick et al

in Nature Reviews. Disease Primers (2016), 2

Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed countries. It is characterized by progressive fibro-calcific remodelling and thickening of the aortic valve leaflets ... [more ▼]

Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed countries. It is characterized by progressive fibro-calcific remodelling and thickening of the aortic valve leaflets that, over years, evolve to cause severe obstruction to cardiac outflow. In developed countries, AS is the third-most frequent cardiovascular disease after coronary artery disease and systemic arterial hypertension, with a prevalence of 0.4% in the general population and 1.7% in the population >65 years old. Congenital abnormality (bicuspid valve) and older age are powerful risk factors for calcific AS. Metabolic syndrome and an elevated plasma level of lipoprotein(a) have also been associated with increased risk of calcific AS. The pathobiology of calcific AS is complex and involves genetic factors, lipoprotein deposition and oxidation, chronic inflammation, osteoblastic transition of cardiac valve interstitial cells and active leaflet calcification. Although no pharmacotherapy has proved to be effective in reducing the progression of AS, promising therapeutic targets include lipoprotein(a), the renin-angiotensin system, receptor activator of NF-kappaB ligand (RANKL; also known as TNFSF11) and ectonucleotidases. Currently, aortic valve replacement (AVR) remains the only effective treatment for severe AS. The diagnosis and staging of AS are based on the assessment of stenosis severity and left ventricular systolic function by Doppler echocardiography, and the presence of symptoms. The introduction of transcatheter AVR in the past decade has been a transformative therapeutic innovation for patients at high or prohibitive risk for surgical valve replacement, and this new technology might extend to lower-risk patients in the near future. [less ▲]

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See detailInsights into abundant rumen ureolytic bacterial community using rumen simulation system
Jin, Di; Zhao, Shengguo; Wang, Pengpeng et al

in Frontiers in Microbiology (2016), 7(1006),

Urea, a non-protein nitrogen for dairy cows, is rapidly hydrolyzed to ammonia by urease produced by ureolytic bacteria in the rumen, and the ammonia is used as nitrogen for rumen bacterial growth. However ... [more ▼]

Urea, a non-protein nitrogen for dairy cows, is rapidly hydrolyzed to ammonia by urease produced by ureolytic bacteria in the rumen, and the ammonia is used as nitrogen for rumen bacterial growth. However, there is limited knowledge with regard to the ureolytic bacteria community in the rumen. To explore the ruminal ureolytic bacterial community, urea, or acetohydroxamic acid (AHA, an inhibitor of urea hydrolysis) were supplemented into the rumen simulation systems. The bacterial 16S rRNA genes were sequenced by Miseq high-throughput sequencing and used to reveal the ureoltyic bacteria by comparing different treatments. The results revealed that urea supplementation significantly increased the ammonia concentration, and AHA addition inhibited urea hydrolysis. Urea supplementation significantly increased the richness of bacterial community and the proportion of ureC genes. The composition of bacterial community following urea or AHA supplementation showed no significant difference compared to the groups without supplementation. The abundance of Bacillus and unclassified Succinivibrionaceae increased significantly following urea supplementation. Pseudomonas, Haemophilus, Neisseria, Streptococcus, and Actinomyces exhibited a positive response to urea supplementation and a negative response to AHA addition. Results retrieved from the NCBI protein database and publications confirmed that the representative bacteria in these genera mentioned above had urease genes or urease activities. Therefore, the rumen ureolytic bacteria were abundant in the genera of Pseudomonas, Haemophilus, Neisseria, Streptococcus, Actinomyces, Bacillus, and unclassified Succinivibrionaceae. Insights into abundant rumen ureolytic bacteria provide the regulation targets to mitigate urea hydrolysis and increase efficiency of urea nitrogen utilization in ruminants. [less ▲]

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See detailEarthworms Eisenia fetida affect the uptake of heavy metals by plants Vicia faba and Zea mays in metal-contaminated soils
Lemtiri, Aboulkacem ULg; Liénard, Amandine ULg; Alabi, Taofic ULg et al

in Applied Soil Ecology (2016), 104

Earthworms increase the availability of heavy metals in some situations and aid in maintaining the structure and quality of soil. The introduction of earthworms into metal-contaminated soils has been ... [more ▼]

Earthworms increase the availability of heavy metals in some situations and aid in maintaining the structure and quality of soil. The introduction of earthworms into metal-contaminated soils has been suggested as an aid for phytoremediation processes. In Wallonia, Belgium, a century of industrial metallurgic activities has led to the substantial pollution of soils by heavy metals, including copper (Cu), zinc (Zn), lead (Pb) and cadmium (Cd), due to atmospheric dusts. Two plant species, Vicia faba and Zea mays, and earthworms (Eisenia fetida) (Savigny, 1826) were exposed to different concentrations of long-term-contaminated soils for 42 days. The soil samples, which were collected from the land surrounding a former Zn-Pb ore-treatment plant, exhibited different levels of heavy metals. Our aim was to evaluate the role of earthworms E. fetida on the availability of metals in soils and their effects on metal uptake by V. faba and Z. mays plants at different soil concentrations. The results suggest that earthworms and plants modified the availability of metals in contaminated soils after 42 days of exposure. Earthworm life-cycle parameters were affected by metal contamination and/or the addition of plants; cocoon production and weight were more responsive to adverse conditions than earthworm survival or weight change. The concentrations of Pb and Cd in earthworm tissues decreased in the presence of plants. Results showed that metal accumulation in plants depended on the metal element considered and the presence of earthworms. However, the presence of earthworms did not change the concentrations of metals in plants, except for Cd. In the presence or absence of earthworms, V. faba accumulated higher concentrations of Cu and Zn compared with Z. mays, which accumulated higher concentrations of Cd. These findings have revealed that earthworm activities can modify the availability of heavy metals for uptake by plants in contaminated soils. Moreover, the study results show that the ecological context of phytoremediation should be broadened by considering earthworm-plant-soil interaction, which influence both the health of the plant and the uptake of heavy metals by plants. [less ▲]

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See detailClosing a gap in tropical forest biomass estimation : taking crown mass variation into account in pantropical allometries
Ploton, Pierre; Barbier, Nicolas; Takoudjou Momo, Stéphane et al

in Biogeosciences (2016), 13

Accurately monitoring tropical forest carbon stocks is a challenge that remains outstanding. Allometric models that consider tree diameter, height and wood density as predictors are currently used in most ... [more ▼]

Accurately monitoring tropical forest carbon stocks is a challenge that remains outstanding. Allometric models that consider tree diameter, height and wood density as predictors are currently used in most tropical forest carbon studies. In particular, a pantropical biomass model has been widely used for approximately a decade, and its most recent version will certainly constitute a reference model in the coming years. However, this reference model shows a systematic bias towards the largest trees. Because large trees are key drivers of forest carbon stocks and dynamics, understanding the origin and the consequences of this bias is of utmost concern. In this study, we compiled a unique tree mass data set of 673 trees destructively sampled in five tropical countries (101 trees > 100 cm in diameter) and an original data set of 130 forest plots (1 ha) from central Africa to quantify the prediction error of biomass allometric models at the individual and plot levels when explicitly taking crown mass variations into account or not doing so. We first showed that the proportion of crown to total tree aboveground biomass is highly variable among trees, ranging from 3 to 88 %. This proportion was constant on average for trees < 10Mg (mean of 34 %) but, above this threshold, increased sharply with tree mass and exceeded 50% on average for trees _45 Mg. This increase coincided with a progressive deviation between the pantropical biomass model estimations and actual tree mass. Taking a crown mass proxy into account in a newly developed model consistently removed the bias observed for large trees (> 1 Mg) and reduced the range of plot-level error (in %) from [-23; 16] to [0; 10]. The disproportionally higher allocation of large trees to crown mass may thus explain the bias observed recently in the reference pantropical model. This bias leads to far-from-negligible, but often overlooked, systematic errors at the plot level and may be easily corrected by taking a crown mass proxy for the largest trees in a stand into account, thus suggesting that the accuracy of forest carbon estimates can be significantly improved at a minimal cost. [less ▲]

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See detailWhat controls the local time extent of flux transfer events?
Milan, S. E.; Imber, S. M.; Carter, J. A. et al

in Journal of Geophysical Research. Space Physics (2016), 121

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See detailCombining microCT-based characterization with empirical modelling as a robust screening approach for the design of optimized CaP-containing scaffolds for progenitor cell-mediated bone formation.
Kerckhofs, G.; Chai, Y. C.; Luyten, F. P. et al

in Acta Biomaterialia (2016), 35

Biomaterials are a key ingredient to the success of bone tissue engineering (TE), which focuses on the healing of bone defects by combining scaffolds with cells and/or growth factors. Due to the widely ... [more ▼]

Biomaterials are a key ingredient to the success of bone tissue engineering (TE), which focuses on the healing of bone defects by combining scaffolds with cells and/or growth factors. Due to the widely variable material characteristics and patient-specificities, however, current bone TE strategies still suffer from low repeatability and lack of robustness, which hamper clinical translation. Hence, optimal TE construct (i.e. cells and scaffold) characteristics are still under debate. This study aimed to reduce the material-specific variability for cell-based construct design, avoiding trial-and-error, by combining microCT characterization and empirical modelling as an innovative and robust screening approach. Via microCT characterization we have built a quantitative construct library of morphological and compositional properties of six CE approved CaP-based scaffolds (CopiOs(R), BioOss, Integra Mozaik, chronOS Vivify, MBCP and ReproBone), and of their bone forming capacity and in vivo scaffold degradation when combined with human periosteal derived cells (hPDCs). The empirical model, based on the construct library, allowed identification of the construct characteristics driving optimized bone formation, i.e. (a) the percentage of beta-TCP and dibasic calcium phosphate, (b) the concavity of the CaP structure, (c) the average CaP structure thickness and (d) the seeded cell amount (taking into account the seeding efficiency). Additionally, the model allowed to quantitatively predict the bone forming response of different hPDC-CaP scaffold combinations, thus providing input for a more robust design of optimized constructs and avoiding trial-and error. This could improve and facilitate clinical translation. STATEMENT OF SIGNIFICANCE: Biomaterials that support regenerative processes are a key ingredient for successful bone tissue engineering (TE). However, the optimal scaffold structure is still under debate. In this study, we have provided a useful innovative approach for robust screening of potential biomaterials or constructs (i.e. scaffolds seeded with cells and/or growth factors) by combining microCT characterization with empirical modelling. This novel approach leads to a better insight in the scaffold parameters influencing progenitor cell-mediated bone formation. Additionally, it serves as input for more controlled and robust design of optimized CaP-containing bone TE scaffolds. Hence, this novel approach could improve and facilitate clinical translation. [less ▲]

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See detailGenome Sequences of Four Strains of Mycobacterium avium subsp. hominissuis, Isolated from Swine and Humans, Differing in Virulence in a Murine Intranasal Infection Model
Bruffaerts; Vluggen, C; Duytschaever, L et al

in Genome Announcements (2016), 4(3),

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See detailMetastable inhomogeneous vortex configuration with non-uniform filling fraction inside a blind hole array patterned in a BSCCO single crystal and concentrating magnetic flux inside it
Shaw, Gorky ULg; Banerjee, S. S.; Tamegai, T. et al

in Superconductor Science and Technology (2016), 29(6), 065021

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See detailA FE2 modelling approach to hydromechanical coupling in cracking-induced localization problems
Van den Eijnden, AP; Bésuelle, Pierre; Chambon, René et al

in International Journal of Solids and Structures (2016), 97

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See detailThe Uptake of 18F-FDG by Renal Allograft in Kidney Transplant Recipients Is Not Influenced by Renal Function.
Jadoul, Alexandre; Lovinfosse, Pierre; Weekers, Laurent et al

in Clinical Nuclear Medicine (2016), 41(9), 683-7

PURPOSE OF THE REPORT: F-FDG PET/CT has been recently proposed as a noninvasive tool for the diagnosis of renal allograft acute rejection (AR) in kidney transplant recipients (KTRs). Still, the influence ... [more ▼]

PURPOSE OF THE REPORT: F-FDG PET/CT has been recently proposed as a noninvasive tool for the diagnosis of renal allograft acute rejection (AR) in kidney transplant recipients (KTRs). Still, the influence of kidney function on F-FDG uptake by renal grafts remains unknown. PATIENTS AND METHODS: We retrospectively identified all KTRs who underwent at least one F-FDG PET/CT. Kidney transplant recipients with documented pyelonephritis or AR were excluded. Estimated glomerular filtration rate (eGFR) was assessed using chronic kidney disease (CKD)-EPI equation. Mean standardized uptake values (SUVmean) of renal graft cortex and aorta were measured in 4 and 1 volumes of interest, respectively. Spearman rank correlation coefficient (rho) and analysis of variance (ANOVA) were performed. RESULTS: Eighty-two KTRs underwent F-FDG PET/CT for tumor staging (n = 46), suspected infection (n = 11), or fever of unknown origin (n = 25). Mean eGFR was 50 +/- 19 mL/min per 1.73 m, including CKD stage 1 (n = 3), stage 2 (n = 21), stage 3a (n = 20), stage 3b (n = 29), and stage 4 (n = 9). Mean kidney and aorta SUVmean were 1.8 +/- 0.2 and 1.7 +/- 0.3, respectively. No significant correlation was observed between eGFR and kidney SUVmean (rho, 0.119; P, 0.28) or aorta SUVmean (rho, -0.144; P, 0.20). ANOVA showed no difference of kidney (P, 0.62) and aorta (P, 0.85) SUVmean between CKD groups. Mean coefficient of variation (on the basis of kidney SUVmean of >3 consecutive F-FDG PET/CT in 15 patients with no significant change of eGFR) reached 13.1%. CONCLUSIONS: The uptake of F-FDG by renal allografts within an hour postinjection is not significantly impacted by CKD. [less ▲]

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See detailHidden Markov Model-based population synthesis
Saadi, Ismaïl ULg; El Saeid Mustafa, Ahmed Mohamed ULg; Teller, Jacques ULg et al

in Transportation Research. Part B : Methodological (2016), 90

Micro-simulation travel demand and land use models require a synthetic population, which consists of a set of agents characterized by demographic and socio-economic attributes. Two main families of ... [more ▼]

Micro-simulation travel demand and land use models require a synthetic population, which consists of a set of agents characterized by demographic and socio-economic attributes. Two main families of population synthesis techniques can be distinguished: (a) fitting methods (iterative proportional fitting, updating) and (b) combinatorial optimization methods. During the last few years, a third outperforming family of population synthesis procedures has emerged, i.e., Markov process-based methods such as Monte Carlo Markov Chain (MCMC) simulations. In this paper, an extended Hidden Markov Model (HMM)-based approach is presented, which can serve as a better alternative than the existing methods. The approach is characterized by a great flexibility and efficiency in terms of data preparation and model training. The HMM is able to reproduce the structural configuration of a given population from an unlimited number of micro-samples and a marginal distribution. Only one marginal distribution of the considered population can be used as a boundary condition to “guide” the synthesis of the whole population. Model training and testing are performed using the Survey on the Workforce of 2013 and the Belgian National Household Travel Survey of 2010. Results indicate that the HMM method captures the complete heterogeneity of the micro-data contrary to standard fitting approaches. The method provides accurate results as it is able to reproduce the marginal distributions and their corresponding multivariate joint distributions with an acceptable error rate (i.e., SRSME=0.54 for 6 synthesized attributes). Furthermore, the HMM outperforms IPF for small sample sizes, even though the amount of input data is less than that for IPF. Finally, simulations show that the HMM can merge information provided by multiple data sources to allow good population estimates. [less ▲]

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See detailReal-time Recordings of Migrating Cortical Neurons from GFP and Cre Recombinase Expressing Mice.
Tielens, Sylvia ULg; Godin, Juliette D.; Nguyen, Laurent ULg

in Current protocols in neuroscience (2016), 74

The cerebral cortex is one of the most intricate regions of the brain that requires elaborate cell migration patterns for its development. Experimental observations show that projection neurons migrate ... [more ▼]

The cerebral cortex is one of the most intricate regions of the brain that requires elaborate cell migration patterns for its development. Experimental observations show that projection neurons migrate radially within the cortical wall, whereas interneurons migrate along multiple tangential paths to reach the developing cortex. Tight regulation of the cell migration processes ensures proper positioning and functional integration of neurons to specific cerebral cortical circuits. Disruption of neuronal migration often leads to cortical dysfunction and/or malformation associated with neurological disorders. Unveiling the molecular control of neuron migration is thus fundamental to understanding the physiological or pathological development of the cerebral cortex. In this unit, protocols allowing detailed analysis of patterns of migration of both interneurons and projection neurons under different experimental conditions (i.e., loss or gain of function) are presented. [less ▲]

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See detailHighlights in migraine electrophysiology: are controversies just reflecting disease heterogeneity?
MAGIS, Delphine ULg; Lisicki Martinez, Marco ULg; Coppola, Gianluca

in Current Opinion in Neurology (2016), 29(3)

PURPOSE OF REVIEW: In migraine, the brain is 'hyperresponsive', which refers to a deficit of habituation to repeated sensory stimuli between attacks. This deficit normalizes in peri-ictal and ictal phases ... [more ▼]

PURPOSE OF REVIEW: In migraine, the brain is 'hyperresponsive', which refers to a deficit of habituation to repeated sensory stimuli between attacks. This deficit normalizes in peri-ictal and ictal phases. A decreased cortical preactivation of thalamo-cortical origin and an impaired intracortical inhibition are probably involved in its pathophysiology. RECENT FINDINGS: The reality of a habituation deficit of visual evoked potentials, a neurophysiological 'hallmark' of interictal migraine, has been questioned. Blinding may be an issue, but some genetic, environmental, or behavioural differences could also exist between populations. A habituation deficit is found interictally in other sensory modalities, and strongly depends on the time of the recordings within the migraine cycle. An impaired thalamocortical drive is demonstrated in interictal phase, and normalizes in ictal phase as well as in chronic migraine, where a strength enhancement of primary cortical activation is observed. An interictal dysexcitability, of subcortical or primary cortical origin, is suggested by magnetic stimulation. These phenomena could occur in varying degrees depending on patients and on the migraine cycle, and account for the heterogeneity of electrophysiological results. SUMMARY: Finding a reliable electrophysiological biomarker for such a multifaceted and cycling disease as migraine is still a challenge. A better standardization of protocols would be worthwhile. [less ▲]

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See detailConvective drying behavior of sawdust-sludge mixtures in a fixed bed
Li, Jie; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Drying Technology (2016), 34(4), 395-402

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See detailInfluence of COMT Genotype on Antero-Posterior Cortical Functional Connectivity Underlying Interference Resolution
Jaspar, Mathieu ULg; Manard, Marine ULg; DIDEBERG, Vinciane ULg et al

in Cerebral Cortex (2016), 26

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates ... [more ▼]

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates. However, this attention has generally centred on the prefrontal cortices because of the well-known direct impact of COMT enzyme on these cerebral regions. In this study, we were interested in the modulating effect of COMT genotype on anterior and posterior brain areas underlying interference resolution during a Stroop task. More specifically, we were interested in the functional connectivity between the right inferior frontal operculum (IFop), an area frequently associated with inhibitory efficiency, and posterior brain regions involved in reading/naming processes (the two main non-executive determinants of the Stroop effect). The Stroop task was administered during fMRI scanning to three groups of 15 young adults divided according to their COMT Val158Met genotype [Val/Val (VV), Val/Met (VM) and Met/Met (MM)]. Results indicate greater activity in the right IFop and the left middle temporal gyrus (MTG) in homozygous VV individuals than in Met allele carriers. In addition, the VV group exhibited stronger positive functional connectivity between these two brain regions and stronger negative connectivity between the right IFop and left lingual gyrus. These results confirm the impact of COMT genotype on frontal function. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task. Especially, changes in functional connectivity between anterior and posterior brain areas might correspond to compensatory processes for performing the task efficiently when the available dopamine level is low. [less ▲]

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See detailEffect of Traveler’s Nationality on Daily Travel Time Expenditure Using Zero-Inflated Negative Binomial Regression Models: Results from Belgian National Household Travel Survey
Eftekhar, Hamed ULg; Creemers, Lieve; Cools, Mario ULg

in Transportation Research Record: Journal of the Transportation Research Board (2016), 2565

In this study, data stemming from the 2010 Belgian National Household Travel Survey were used to assess the effect of a traveler’s nationality on daily travel time expenditure. Negative binomial (zero ... [more ▼]

In this study, data stemming from the 2010 Belgian National Household Travel Survey were used to assess the effect of a traveler’s nationality on daily travel time expenditure. Negative binomial (zero-inflated) models were estimated to isolate the effect of nationality after other contributing factors such as sociodemographics, residential characteristics, transport options, and temporal characteristics were controlled for. The results indicate that even if one controls for a series of other influencing factors, nationality plays a significant role in differences in travel time expenditure. This finding is especially relevant in the development of policy packages that are targeted at social inequalities. From a methodological perspective, methodological options—two weighting schemes and two bootstrap solutions—were presented to provide sufficient support for the conclusions. To generalize the results in further studies, an oversampling of travelers of different nationalities is strongly recommended. Future research should focus more on the underlying psychological constructs of why ethnic and cultural differences persist even if one accounts for other determinants. [less ▲]

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See detailAgricultureIsLife or how to facilitate innovation in agriculture through multi-disciplinary research
Monty, Arnaud ULg; Garré, Sarah ULg; Bindelle, Jérôme ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016)

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See detailIs the Sørensen test valid to assess muscle fatigue of the trunk extensor muscles?
Demoulin, Christophe ULg; Boyer, Mathieu; Duchateau, Jacques et al

in Journal of Back and Musculoskeletal Rehabilitation (2016), 00

BACKGROUND: Very few studies have quantified the degree of fatigue characterized by the decline in the maximal voluntary contraction (MVC) force of the trunk extensors induced by the widely used Sørensen ... [more ▼]

BACKGROUND: Very few studies have quantified the degree of fatigue characterized by the decline in the maximal voluntary contraction (MVC) force of the trunk extensors induced by the widely used Sørensen test. OBJECTIVE: Measure the degree of fatigue of the trunk extensor muscles induced by the Sørensen test. METHODS: Eighty young healthy subjects were randomly divided into a control group (CG) and an experimental group (EG), each including 50% of the two genders. The EG performed an isometric MVC of the trunk extensors (pre-fatigue test) followed by the Sørensen test, the latter being immediately followed by another MVC (post-fatigue test). The CG performed only the preand post-fatigue tests without any exertion in between. RESULTS: The comparison of the pre- and post-fatigue tests revealed a significant (P <0.05) decrease in MVC force normalized by body mass (−13%) in the EG, whereas a small increase occurred in the CG (+2.7%, P = 0.001). CONCLUSIONS: This study shows that the Sørensen test performed until failure in a young healthy population results in a reduced ability of the trunk extensor muscles to generate maximal force, and indicates that this test is valid for the assessment of fatigue in trunk extensor muscles. [less ▲]

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See detailPrise en charge neuropsychologique des troubles attentionnels sans hyperactivité chez l’enfant (TDA) : à propos de deux cas
Turine, Hélène; Catale, Corinne ULg; Lejeune, Caroline et al

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (2016), 141

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See detailImprovement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Hamaïdia, Malik ULg; Staumont, Bernard ULg; DUYSINX, Bernard ULg et al

in Current Topics in Medicinal Chemistry (2016), 16

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor ... [more ▼]

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators. [less ▲]

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See detailHandling Intrahousehold Correlations in Modeling Travel: Comparison of Hierarchical Models and Marginal Models
Cools, Mario ULg; Moons, Elke

in Transportation Research Record: Journal of the Transportation Research Board (2016), 2565

In this study, the necessity for treating intrahousehold correlation was investigated by analyzing two travel behavior indexes, travel time and travel distance, for three important travel motivations ... [more ▼]

In this study, the necessity for treating intrahousehold correlation was investigated by analyzing two travel behavior indexes, travel time and travel distance, for three important travel motivations (commuting, shopping, and leisure). Data stemming from the 2010 Belgian National Household Travel Survey were used in the analysis. Two model approaches that accommodated intrahousehold correlation were compared, namely, the generalized linear mixed model (GLMM) and the generalized estimating equation (GEE) model. Both model approaches showed that high levels of intrahousehold correlation were present, and therefore the use of models that took into account intrahousehold correlation was strongly recommended. Results indicated that this requirement was the most urgent for noncommuting trips. Moreover, the results showed that the GLMM and the GEE model yielded comparable estimates in the case of normally distributed data. Furthermore, evidence was provided that the more the estimates of the intrahousehold correlation provided by the two approaches differed, the less the homogeneity of the parameters was ensured. In this regard, if one has to choose between the GLMM and the GEE model, the negative consequences of choosing an inappropriate covariance model in the case of GLMM especially favor the selection of the GEE model. Further research is needed to compare the two approaches in the context of nonnormally distributed travel behavior data. [less ▲]

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See detailBovine Staphylococcus aureus: Subtyping, evolution, and zoonotic transfer.
Boss, R.; Cosandey, A.; Luini, M. et al

in Journal of dairy science (2016), 99(1), 515-28

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that ... [more ▼]

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that Staph. aureus isolated from bovine intramammary infections are genetically heterogeneous, with Staph. aureus genotype B (GTB) and GTC being the most prominent genotypes. Furthermore, Staph. aureus GTB was found to be contagious, whereas Staph. aureus GTC and all the remaining genotypes were involved in individual cow disease. In addition to RS-PCR, other methods for subtyping Staph. aureus are known, including spa typing and multilocus sequence typing (MLST). They are based on sequencing the spa and various housekeeping genes, respectively. The aim of the present study was to compare the 3 analytic methods using 456 strains of Staph. aureus isolated from milk of bovine intramammary infections and bulk tanks obtained from 12 European countries. Furthermore, the phylogeny of animal Staph. aureus was inferred and the zoonotic transfer of Staph. aureus between cattle and humans was studied. The analyzed strains could be grouped into 6 genotypic clusters, with CLB, CLC, and CLR being the most prominent ones. Comparing the 3 subtyping methods, RS-PCR showed the highest resolution, followed by spa typing and MLST. We found associations among the methods but in many cases they were unsatisfactory except for CLB and CLC. Cluster CLB was positive for clonal complex (CC)8 in 99% of the cases and typically positive for t2953; it is the cattle-adapted form of CC8. Cluster CLC was always positive for tbl 2645 and typically positive for CC705. For CLR and the remaining subtypes, links among the 3 methods were generally poor. Bovine Staph. aureus is highly clonal and a few clones predominate. Animal Staph. aureus always evolve from human strains, such that every human strain may be the ancestor of a novel animal-adapted strain. The zoonotic transfer of IMI- and milk-associated strains of Staph. aureus between cattle and humans seems to be very limited and different hosts are not considered as a source for mutual, spontaneous infections. Spillover events, however, may happen. [less ▲]

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See detailNeural Activation During Mental Rotation in Complete Androgen Insensitivity Syndrome: the Influence of Sex Hormones and Sex Chromosomes.
van Hemmen, Judy; Veltman, Dick J.; Hoekzema, Elseline et al

in Cerebral Cortex (2016)

Sex hormones, androgens in particular, are hypothesized to play a key role in the sexual differentiation of the human brain. However, possible direct effects of the sex chromosomes, that is, XX or XY ... [more ▼]

Sex hormones, androgens in particular, are hypothesized to play a key role in the sexual differentiation of the human brain. However, possible direct effects of the sex chromosomes, that is, XX or XY, have not been well studied in humans. Individuals with complete androgen insensitivity syndrome (CAIS), who have a 46,XY karyotype but a female phenotype due to a complete androgen resistance, enable us to study the separate effects of gonadal hormones versus sex chromosomes on neural sex differences. Therefore, in the present study, we compared 46,XY men (n = 30) and 46,XX women (n = 29) to 46,XY individuals with CAIS (n = 21) on a mental rotation task using functional magnetic resonance imaging. Previously reported sex differences in neural activation during mental rotation were replicated in the control groups, with control men showing more activation in the inferior parietal lobe than control women. Individuals with CAIS showed a female-like neural activation pattern in the parietal lobe, indicating feminization of the brain in CAIS. Furthermore, this first neuroimaging study in individuals with CAIS provides evidence that sex differences in regional brain function during mental rotation are most likely not directly driven by genetic sex, but rather reflect gonadal hormone exposure. [less ▲]

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See detailPas d'obstacle constitutionnel pour les sanctions administratives communales
Michiels, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), (2016/1), 79-99

Le législateur, lors de l’instauration du système des sanctions administratives communales, a entendu combattre les incivilités. Cette notiond’«incivilité» vise des comportements dans l’espace public qui ... [more ▼]

Le législateur, lors de l’instauration du système des sanctions administratives communales, a entendu combattre les incivilités. Cette notiond’«incivilité» vise des comportements dans l’espace public qui s’écartent de ce qui est convenable dans la vie en société. En veillant à définir les «incivilités» comme les formes les plus légères de trouble de l’ordre public, de la sécurité, de la santé et de la propreté, qui sont dégradants ou incommodants et qui dépassent les contraintes normales de la vie sociale, le législateur a satisfait aux exigences du principe de légalité.Le droit à une bonne administration de la justice tel qu’il est garanti par l’article 6 de la Convention européenne des droits de l’homme, n’exclut pas qu’une sanction administrative soit infligée par un fonctionnaire, à condition qu’un juge indépendant et impartial puisse exercer un contrôle de pleine juridic-tion sur cette décision administrative. [less ▲]

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See detailLa correction de l’expression écrite en langue étrangère et son exploitation pédagogique. Expliciter l’implicite ?
Noiroux, Kevin ULg; Simons, Germain ULg

in Les cahiers de l’Association des chercheurs et enseignants didacticiens des langues étrangères (acedle) (2016)

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See detailDopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Borgs, Laurence; Peyre, Elise ULg; Alix, Philippe et al

in Scientific Reports (2016), 6

Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson's disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To understand the pathophysiology of ... [more ▼]

Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson's disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To understand the pathophysiology of this mutation and its possible developmental implications, we developed an in vitro assay to model PD with human induced pluripotent stem cells (hiPSCs) reprogrammed from skin fibroblasts of PD patients suffering from the LRKK2 G2019S mutation. We differentiated the hiPSCs into neural stem cells (NSCs) and further into dopaminergic neurons. Here we show that NSCs bearing the mutation tend to differentiate less efficiently into dopaminergic neurons and that the latter exhibit significant branching defects as compared to their controls. [less ▲]

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See detailScientific Problems Addressed by the Spektr-UV Space Project (World Space Observatory—Ultraviolet)
Boyarchuk, A.A.; others; Gérard, Jean-Claude ULg et al

in Astronomy Reports (2016), 60(1), 1-42

The article presents a review of scientific problems and methods of ultraviolet astronomy, focusing on perspective scientific problems (directions) whose solution requires UV space observatories. These ... [more ▼]

The article presents a review of scientific problems and methods of ultraviolet astronomy, focusing on perspective scientific problems (directions) whose solution requires UV space observatories. These include reionization and the history of star formation in the Universe, searches for dark baryonic matter, physical and chemical processes in the interstellar medium and protoplanetary disks, the physics of accretion and outflows in astrophysical objects, from Active Galactic Nuclei to close binary stars, stellar activity (for both low-mass and high-mass stars), and processes occurring in the atmospheres of both planets in the solar system and exoplanets. Technological progress in UV astronomy achieved in recent years is also considered. The well advanced, international, Russian-led Spektr-UV (World Space Observatory—Ultraviolet) project is described in more detail. This project is directed at creating a major space observatory operational in the ultraviolet (115–310 nm). This observatory will provide an effective, and possibly the only, powerful means of observing in this spectral range over the next ten years, and will be an powerful tool for resolving many topical scientific problems. [less ▲]

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See detailNewt life after fish introduction: extirpation of paedomorphosis in a mountain fish lake and newt use of satellite pools
Denoël, Mathieu ULg; Scime, Patrick; Zambelli, Nicola

in Current Zoology (2016), 62(1), 61-69

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context ... [more ▼]

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context, we determined whether small wetlands, such as pools surrounding fished and fishless lakes, could sustain paedomorphic and metamorphic newts. To this end, we surveyed lakes known historically to sustain Alpine newts (Ichthyosaura alpestris) as well as 35 nearby pools. On the basis of the published records, the only known population exhibiting paedomorphosis in the Swiss Alps was found to be extirpated by salmonid introductions. However, the metamorphs persisted in peripheral pools, paedomorphosis was discovered at a new locality, and overwintering larvae were still present in one of the lakes. These results show the importance of conserving varied aquatic habitats such as pools in mountainous environments where the main resources can become unsuitable for amphibians because of fish introductions. Pools may also function as reservoirs in maintaining newt populations until programs to remove fish from lakes can be carried out. It is not known if paedomorphs could reappear after fish removal. However, the combined resilience of amphibians after fish removal and the genetic basis for paedomorphosis highlighted in other taxa by previous studies suggest that there is the potential to maintain this intraspecific case of diversity even after its disappearance. [less ▲]

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See detailThe Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Cao, Martine ULg; Royce, Darlene B.; Risingsong, Renee et al

in Cancer prevention research (Philadelphia, Pa.) (2016), 9(1), 105-14

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both ... [more ▼]

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both drugs are useful for prevention of lung cancer in A/J mice. These molecules markedly reduced tumor number, tumor size, and total tumor burden, when chronically administered to A/J mice that had been initiated with the mutagenic carcinogen, vinyl carbamate. Moreover, LG100268 synergized with the histone deacetylase inhibitor, vorinostat, for prevention of experimental lung cancer and enhanced the effect of carboplatin/paclitaxel for treatment of experimental lung cancer. Both rexinoids diminished the percentage of high-grade, highly malignant adenocarcinomas found at autopsy. In cell culture studies, the rexinoids exhibited potent anti-inflammatory properties at nanoMolar concentrations. These drugs suppressed the ability of lipopolysaccharide to stimulate the synthesis and secretion of nitric oxide and inflammatory cytokines and chemokines, such as IL6, IL1beta, CXCL2, and CSF3, in macrophage-like RAW264.7 cells. The present results suggest that LG100268, LG101506, or a related rexinoid may have useful clinical applications in the field of oncology. Cancer Prev Res; 9(1); 105-14. (c)2015 AACR. [less ▲]

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See detailTranscriptome of the freshwater amphipod Gammarus pulex hepatopancreas
Gismondi, Eric ULg; Thomé, Jean-Pierre ULg

in Genomics Data (2016), 8

So far, ecotoxicological studies used biomarkers of exposure or of effects in order to investigate the impacts of contaminated areas on biota (Peakall, 1994 [6]). However, although these results are ... [more ▼]

So far, ecotoxicological studies used biomarkers of exposure or of effects in order to investigate the impacts of contaminated areas on biota (Peakall, 1994 [6]). However, although these results are important in the ecotoxicological risk assessment, biomarkers are very specific and only provide information on the biological processes or physiological pathways targeted by the biomarkers experimenters choose to test (Monsinjon and Knigge, 2007 [5]). In recent years, proteomics have become a major tool in ecotoxicology, as they provide a global insight into the mechanism of action of pollutants without the need of hypothesis testing or any preconception on the biological processes likely impacted (Gismondi et al., 2015; Trapp et al., 2015 [7]; Truebano, 2016 [8]). However, the analysis of proteomic results is often limited due to the lack of database, especially for non-model organisms, such as Gammarus sp, commonly used as biological model in ecotoxicology (Sornom et al., 2012 [11]; Vellinger et al., 2013 [9]; Gismondi and Thomé, 2014 [1]; Lebrun et al., 2014 [3]). Here, we performed Illumina HiSeq sequencing to total RNA isolated from the hepatopancreas (i.e. detoxification tissue) of Gammarus pulex males and females coming from uncontaminated river and contaminated river (e.g. PCB, benzo(a)pyrene). Approximately 290Mpaired-end readswere assembled, filtered and sorted into 39,801 contigswhose 10.878 were similar of proteins available in databases. The assembled contigs could represent a reference hepatopancreas transcriptome for G. pulex, and constitute an important resource for future investigations on the impacts of pollutants on invertebrate biota, since itwould improve the understanding of the mechanisms of action involved in toxicity. In addition, the hepatopancreas transcriptome will also allow the identification of new potential biomarkers for the ecotoxicological risk assessments. Assembled contigswere deposited in the European Nucleotide Archive under the BioProject number PRJEB13055, with accession numbers FJVI01000001-FJVI01039801. [less ▲]

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See detailMeningitis and orchitis in a hare (Lepus Europaeus) infected with Francisella tularensis
Grégoire, Fabien; Cassart, Dominique ULg; Desmecht, Daniel ULg et al

in Veterinary Records Case Reports (2016), 4(e000306),

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See detail"Translating Multilayered Sensory Experience"
Bada, Valérie ULg; Pagnoulle, Christine ULg

in Palimpsestes (2016)

The powerful impact of the plays by African American playwright August Wilson largely relies on the way his words appeal to the senses, whether explicitly by calling upon the characters’ sensory ... [more ▼]

The powerful impact of the plays by African American playwright August Wilson largely relies on the way his words appeal to the senses, whether explicitly by calling upon the characters’ sensory experience or more indirectly through his use of syntactic rhythm, or indeed his specific modulation of AAVE. This article describes how the translators tried to create a French idiom that induces the same sensory impact on an audience and, at the same time, reflects the multilayered referentiality of the text. [less ▲]

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See detailTropical moss floras: a homogeneous assemblage of highly mobile species? Insights from their spatial patterns of beta diversity
Nik Norhazrina Binti Nik Mohd Kamil, ULg; Jairo, Patiño; Laurens, Geffert et al

in Botanical Journal of the Linnean Society (2016)

The biotic poverty of tropical Africa has been interpreted in terms of massive extinctions caused by historical climate shifts. While recolonisation has been hampered in tropical angiosperms that are ... [more ▼]

The biotic poverty of tropical Africa has been interpreted in terms of massive extinctions caused by historical climate shifts. While recolonisation has been hampered in tropical angiosperms that are characterized by low dispersal capacities, tropical bryophytes exhibit high dispersal syndromes. Using tropical mosses as a model, we test here the hypotheses that (i) species-turnover is higher within than among continents and (ii) in tropical Africa, extant distribution patterns are better explained by variation in environmental conditions (species turnover) than by the ordered loss of species along gradients of recolonisation from putative refugia (species nestedness). Global beta diversity was slightly, but significantly higher among than within tropical regions, suggesting that geographic isolation rather than regional environmental variation shapes macroecological patterns of moss species distributions. Species turnover was, however, systematically higher than nestedness within each tropical region, and nestedness in tropical Africa was not significantly higher than in other tropical regions. The results therefore do not support the hypothesis of an ordered loss of species due to delays in the recolonisation of formerly savanna areas from refugia. Rather, the low species richness in Africa is interpreted in terms of shifts towards specialized, but species-poor communities along sharp ecological gradients. [less ▲]

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See detailOptimization of a cheap and residential small-scale production of edible crickets with local by-products as an alternative protein-rich human food source in Ratanakiri Province (Cambodia)
Caparros Megido, Rudy ULg; Alabi, Taofic ULg; Nieus, Clément et al

in Journal of the Science of Food and Agriculture (2016)

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may ... [more ▼]

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may represent a sustainable, cost effective and high quality alternative source of protein to traditional livestock. This study aimed to optimise a cheap and residential cricket breeding system based on unused wild resources. The cricket development, Teleogryllus testaceus (Walker), under seven diets composed of taro aerial parts, young cassava leaves, young cashew leaves and brown rice flour (with or without banana slices), versus a traditionally used broiler feed diet was studied. Results - Cricket mortality was low in all diets, except the two cashew-based diets. Total biomass was significantly higher under the broiler feed, in addition to the two diets containing a combination of cassava leaf powder and brown rice. Yet, crickets fed with the taro diet had the highest percentage of protein. Concerning the breeding system cost, units using cassava leaves were the cheapest ones. Conclusion – Diets based of cassava leaves seems to be the most promising ones. Nevertheless, to produce crickets with a high body mass and a high protein level, a new experiment must be realised in which the cassava leaf maturity will be adapted to fit with the cricket growth stage. Moreover, to reduce the cost of the breeding units, handmade local products should be used instead of purchased components. [less ▲]

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See detailDementia-specific quality of life instruments: a conceptual analysis
Missotten, Pierre ULg; Dupuis, Gilles; Adam, Stéphane ULg

in International Psychogeriatrics (2016), 28(8), 1245-1262

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the ... [more ▼]

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the conceptual frameworks of the dementia-specific QoL instruments, to identify their evolution over time and to provide elements of reflection on the QoL concept in dementia and its evaluation. Method: An electronic search was conducted on PsycINFO and MEDLINE databases, from January 1985 to June 2015 using a combination of key words that include quality of life, dementia and review. Result: The analysis of the conceptual frameworks of the eighteen selected dementia-specific QoL tools shows a great diversity in: (1) the QoL definitions (e.g. health-related QoL definitions, QoL definitions based on Lawton’s work or similar to this latter); (2) the theoretical QoL models (e.g. Lawton’ work and modified Lawton, adaptation, personhood); (3) the domains and dimensions; (4) the way to construct the instrument (e.g. development based on literature, opinion of the experts) and (5) the items’ formulation (e.g. use of criterion of intensity or frequency). Conclusion: There are different conceptual frameworks in the dementia-specific QoL measures with improvements over time (e.g. inclusion of interesting concepts such as adaptation, taking into account the views of patients themselves). Each of the conceptual parameters (definitions, models, domains and dimensions) is discussed to identify the scales that are conceptually the strongest. Through their review, recommendations for future instrument refinement and development are discussed and a new QoL definition is proposed. [less ▲]

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See detailChemoautotrophy and anoxygenic photosynthesis within the water column of a large meromictic tropical lake (Lake Kivu, East Africa)
Morana, Cédric; Roland, Fleur ULg; Crowe, Sean A. et al

in Limnology and Oceanography (2016)

We quantified chemoautotrophic and anoxygenic photosynthetic microbial production in the water column of Lake Kivu, a permanently stratified tropical lake situated amidst volcanic activity, and aimed to ... [more ▼]

We quantified chemoautotrophic and anoxygenic photosynthetic microbial production in the water column of Lake Kivu, a permanently stratified tropical lake situated amidst volcanic activity, and aimed to identify the microorganisms involved in these processes through the analysis of their phospholipid fatty acid (PLFA) content and stable isotope (13C) labelling of PLFA in a set of incubation experiments. Data demonstrate the existence of a biogeochemically active chemoautotrophic bacterial community in the redoxcline of Lake Kivu (50–70 m). PLFA data indicate that the bacterial communities are structured vertically in the water column, with a large dissimilarity between the oxic and anoxic waters. Maximum volumetric dark CO2 fixation rates measured in Lake Kivu were in the same range as values reported from H2S-rich marine redoxclines, such as the Black and Baltic Seas, and the Cariaco Basin. Similarly, maximal chemoautotrophic activities in Lake Kivu were observed in sulfidic waters, just below the oxycline. Anoxygenic photosynthetic production was never observed in the main basin of Lake Kivu. However, anoxygenic phototrophs largely dominated CO2 fixation in the illuminated redoxcline of Kabuno Bay, a shallower ferruginous sub-basin. Overall, this study supports the idea that chemoautotrophs and/or anoxygenic photoautotrophs might play an important role in the flow of carbon and energy in permanently stratified tropical ecosystems. In Lake Kivu, these processes significantly contribute to organic matter biosynthesis and exert an indirect control on oxygenic photoautotrophs by shortcircuiting the vertical transport of nutrients to the illuminated and oxygenated surface waters. [less ▲]

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See detailReview of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014
Comblain, Fanny ULg; Serisier, Samuel; Barthelemy, Nicolas ULg et al

in Journal of Veterinary Pharmacology & Therapeutics (2016), 39

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See detailLa couverture santé universelle dans les pays à revenus faibles et intermédiaires : analyses économiques
Paul, Elisabeth ULg; Bodson, Oriane ULg; Ridde, Valéry et al

in Reflets et Perspectives de la Vie Economique (2016), 1

Les pays à revenu faible et intermédiaire sont confrontés à des besoins de financement élevés pour assurer une couverture santé universelle (CSU) permettant à chacun d'avoir accès à des services de santé ... [more ▼]

Les pays à revenu faible et intermédiaire sont confrontés à des besoins de financement élevés pour assurer une couverture santé universelle (CSU) permettant à chacun d'avoir accès à des services de santé de qualité sans encourir de difficultés financières. Cet article tente de montrer comment l'analyse économique peut être mobilisée pour identifier des stratégies utiles pour tendre vers la CSU. Trois axes complémentaires où l'analyse économique a une plus-value sont présentés : i) la mobilisation des ressources et l'équité verticale ; ii) l'amélioration de l'efficacité dans l'allocation des ressources et l'équité horizontale ; iii) la gestion opérationnelle des ressources, en particulier à travers le financement basé sur les résultats (efficience). Pour chacun, nous présentons un bref état des lieux de l'état des connaissances et évoquons quelques perspectives de recherche. [less ▲]

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See detailStratigraphy and depositional environments of the Late Famennian (Late Devonian) of Southern Belgium and characterization of the Strud locality
Denayer, Julien ULg; Prestianni, Cyrille; Gueriau, Pierre et al

in Geological Magazine (2016), 153(1), 112-127

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods ... [more ▼]

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods. The Strud locality has yielded a diverse flora and fauna including seed-plants, tetrapods, various placoderm, actinopterygian, acanthodian and sarcopterygian fishes, crustaceans (anostracans, notostracans, conchostracans and decapods) and a putative complete insect. This fossil assemblage is one of the oldest continental – probably fresh-water – ecosystems with a considerable vertebrate and invertebrate diversity. The study of the palaeoenvironment of the Strud locality is crucial because it records one of the earliest and most important phases of tetrapod evolution that took place after their emergence but before their terrestrialization. It raises the question of environmental and ecological conditions for the Devonian aquatic ecosystem and the selection pressures occurring at the onset of tetrapod terrestrialization. The present study characterized the fluvial facies of the Upper Famennian sedimentary rocks of Strud and the surrounding areas. The exceptional preservation of arthropods and plants in the main fossiliferous layers is explained by rapid burial in the fine-grained sediment of the quiet and confined flood plain environment. Newly investigated fossiliferous sections in the Meuse–Samson area led to the description and correlation of key sections (Strud, Wierde and Jausse sections, complemented by the less continuous Haltinne, Huy and Coutisse sections). Moreover, the investigated sections allowed a review of the age of the fossiliferous horizon, which is now definitely considered to be Late Famennian in age. [less ▲]

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See detailQuality of documentation on antibiotic therapy in medical records: evaluation of combined interventions in a teaching hospital by repeated point prevalence survey.
VERCHEVAL, Christelle ULg; Gillet, Marie-Claire ULg; MAES, Nathalie ULg et al

in European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology (2016), 35(9), 14951500

This study aimed to improve the quality of documentation on antibiotic therapy in the computerized medical records of inpatients. A prospective, uncontrolled, interrupted time series (ITS) study was ... [more ▼]

This study aimed to improve the quality of documentation on antibiotic therapy in the computerized medical records of inpatients. A prospective, uncontrolled, interrupted time series (ITS) study was conducted by repeated point prevalence survey (PPS) to audit the quality of documentation on antibiotic therapy in the medical records before and after a combined intervention strategy (implementation of guidelines, distribution of educational materials, educational outreach visits, group educational interactive sessions) from the antimicrobial stewardship team (AST) in the academic teaching hospital (CHU) of Liege, Belgium. The primary outcome measure was the documentation rate on three quality indicators in the computerized medical records: (1) indication for treatment, (2) antibiotics prescribed, and (3) duration or review date. Segmented regression analysis was used to analyze the ITS. The medical records of 2306 patients receiving antibiotics for an infection (1177 in the pre-intervention period and 1129 in the post-intervention period) were analyzed. A significant increase in mean percentages in the post-intervention period was observed as compared with the pre-intervention period for the three quality indicators (indication documented 83.4 +/- 10.4 % vs. 90.3 +/- 6.6 %, p = 0.0013; antibiotics documented 87.9 +/- 9.0 % vs. 95.6 +/- 5.1 %, p < 0.0001; and duration or review date documented 31.9 +/- 15.4 % vs. 67.7 +/- 15.2 %, p < 0.0001). The study demonstrated the successful implementation of a combined intervention strategy from the AST. This strategy was associated with significant changes in the documentation rate in the computerized medical records for the three quality indicators. [less ▲]

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See detailThe Influence of Equivalent Contact Area Computation in 3D Extended Node to Surface Contact Elements
Wautelet, Gaëtan ULg; Papeleux, Luc ULg; Ponthot, Jean-Philippe ULg

in Key Engineering Materials [=KEM] (2016), 681

This paper extends the frictionless penalty-based node to contact formulation with area regularization to a 3D framework. Based on our previous work [1] focused on axisymmetric modeling, two computational ... [more ▼]

This paper extends the frictionless penalty-based node to contact formulation with area regularization to a 3D framework. Based on our previous work [1] focused on axisymmetric modeling, two computational methods are also considered for the determination of the slave node area. The first method, named as the geometrical approach, is based on a force equivalence system, while the second one, named as the consistent approach, is derived from a more sophisticated scheme elaborated upon the virtual work principle. Then, the extended contact elements are derived for the contact formulations with geometrical and consistent area regularization and a consistent linearization is provided accordingly, which guarantees a quadratic rate of convergence of the global Newton Raphson iterative procedure. Finally, two numerical examples assess the performance of both contact formulations with area regularization and demonstrates the robustness and the efficiency of the node to surface contact formulation with consistent area regularization in reproducing a constant contact pressure distribution across the interface between a deformable body and a analytically-defined rigid body, irrespective of the mesh. Our findings will certainly encourage further developments towards the design of a penalty based node to surface contact algorithm passing the contact patch test, as was already done successfully in 2D contact problems [2]. [less ▲]

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See detailComposite joints under M-N at elevated temperatures
Haremza, Cécile; Santiago, Aldina; Demonceau, Jean-François ULg et al

in Journal of Constructional Steel Research (2016), 124

The Eurocodes recognise robustness as a way to ensure the structural integrity of a building frame subjected to an unforeseen event and therefore to avoid a so-called “progressive failure” mode in extreme ... [more ▼]

The Eurocodes recognise robustness as a way to ensure the structural integrity of a building frame subjected to an unforeseen event and therefore to avoid a so-called “progressive failure” mode in extreme loading situations. However, few practical guidelines exist nowadays which would allow a designer to design a structure accordingly. Within the European RFCS ROBUSTFIRE project, the behaviour of steel and composite car parks subjected to localised fire leading to a column loss was investigated. Under such a scenario, the beam-to-column joints play a key role in the global structural response. Indeed, these joints, initially loaded in bending, may be subjected to elevated temperatures and to combined axial load “N”, bending moment “M” and shear forces “V”. In this paper, a methodology to predict the mechanical response of bolted composite beam-to-column joints at elevated temperatures under M-N is presented and validated through comparison with detailed numerical results and experimental tests. This methodology is based on an analytical method able to predict M-N resistance interaction curves for steel and composite joints and which is in full agreement with the component model recommended by the Eurocode. [less ▲]

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See detailPlant evolution and terrestrialization during Palaeozoic times - the phylogenetic context
Gerrienne, Philippe ULg; Servais, Thomas; Vecoli, Marco

in Review of Palaeobotany and Palynology (2016)

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See detailPHYTOCHEMICAL ANALYSIS OF FUMARIA OFFICINALIS L. (FUMARIACEAE)
Paltinean, Ramona; Toiu, Anca; Wauters, Jean-Noël ULg et al

in Farmacia (2016), 64(3), 409-413

The present study describes the investigation of active compounds from several samples of Fumaria officinalis L. (Fumariaceae). The identification of the isoquinoline alkaloids (allocryptopine ... [more ▼]

The present study describes the investigation of active compounds from several samples of Fumaria officinalis L. (Fumariaceae). The identification of the isoquinoline alkaloids (allocryptopine, chelidonine, protopine, bicuculline, sanguinarine, cheleritrine, stylopine and hydrastine) was performed by comparison with reference standards using an HPLC-DAD method, and their quantification by LC-DAD and spectrophotometric methods. The presence of polyphenolic compounds was simultaneously assessed by HPLC. Protopine and sanguinarine were identified in all extracts. The major alkaloids were protopine and chelidonine (258.3 mg/100 g and respectively 94.13 mg/100 g). The spectrophotometric determinations of alkaloids showed minor differences between commercial samples and those harvested from spontaneous flora. The concentration of isoquinoline alkaloids expressed in chelidonine was between 0.69 and 0.76% in all samples. The pattern of phenol carboxylic acids showed the presence of cynarin, chlorogenic, isochlorogenic and ferulic acids. The flavonoids isovitexin, rutin, isoquercitrin and quercitrin were found in all assessed samples of Fumaria officinalis aerial parts. [less ▲]

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See detailUnveiling Network and Service Performance Degradation in the Wild with mPlane
Casas, Pedro; Fiadino, Pierdomenico; Wassermann, Sarah ULg et al

in IEEE Communications Magazine - Network Testing Series (2016)

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity ... [more ▼]

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity. However, its distributed nature leads to operational brittleness and difficulty in identifying the root causes of performance degradation. In such a context, network measurements are a fundamental pillar to shed light and to unveil design and implementation defects. To tackle this fragmentation and visibility problem, we have recently conceived mPlane, a distributed measurement platform which runs, collects and analyses traffic measurements to study the operation and functioning of the Internet. In this paper, we show the potentiality of the mPlane approach to unveil network and service degradation issues in live, operational networks, involving both fixed-line and cellular networks. In particular, we combine active and passive measurements to troubleshoot problems in end-customer Internet access connections, or to automatically detect and diagnose anomalies in Internet-scale services (e.g., YouTube) which impact a large number of end-users. [less ▲]

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See detailIdentification and frequencies of cystic fibrosis mutations in central Argentina.
Pepermans, Xavier; Mellado, Soledad; Chialina, Sergio et al

in Clinical biochemistry (2016)

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See detailCan computer vision problems benefit from structured hierarchical classification?
Hoyoux, Thomas ULg; Rodríguez-Sánchez, Antonio J.; Piater, Justus H.

in Machine Vision & Applications (2016)

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See detailSources of dissolved silica to the fjords of northern Patagonia (44–48°S): the importance of volcanic ash soil distribution and weathering
Vandekerkhove, Elke; Bertrand, Sébastien; Reid, Brian et al

in Earth Surface Processes and Landforms (2016), 41(4), 499-512

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See detailNew insights into sound production in Carapus mourlani (Carapidae)
Parmentier, Eric ULg; Colleye, Orphal ULg; Lecchini, David

in Bulletin of Marine Science (2016), 92(3),

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See detailHigh-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey.
Assfalg, Volker; Huser, Norbert; van Meel, Marieke et al

in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2016)

BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement ... [more ▼]

BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement therapy. Data on the outcomes of HU transplantation are sparse and the benefit is controversial. METHODS: We systematically analysed data from 898 ET HU kidney transplant recipients from 61 transplant centres between 1996 and 2010 and investigated the 5-year patient and graft outcomes and differences between relevant subgroups. RESULTS: Kidney recipients with an HU status were younger (median 43 versus 55 years) and spent less time on the waiting list compared with non-HU recipients (34 versus 54 months). They received grafts with significantly more mismatches (mean 3.79 versus 2.42; P < 0.001) and the percentage of retransplantations was remarkably higher (37.5 versus 16.7%). Patient survival (P = 0.0053) and death with a functioning graft (DwFG; P < 0.0001) after HU transplantation were significantly worse than in non-HU recipients, whereas graft outcome was comparable (P = 0.094). Analysis according to the different HU indications revealed that recipients listed HU because of an imminent lack of access for dialysis had a significantly worse patient survival (P = 0.0053) and DwFG (P = 0.0462) compared with recipients with psychological problems and suicidality because of dialysis. In addition, retransplantation had a negative impact on patient and graft outcome. CONCLUSIONS: Facing organ shortages, increasing wait times and considerable mortality on dialysis, we question the current policy of HU allocation and propose more restrictive criteria with regard to individuals with vascular complications or repeated retransplantations in order to support patients on the non-HU waiting list with a much better long-term prognosis. [less ▲]

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See detailComment je traite… L’insomnie chronique par la thérapie comportementale et cognitive
Dethier, Marie ULg; Blairy, Sylvie ULg; POIRRIER, Robert ULg

in Revue Médicale de Liège (2016)

L’insomnie est actuellement traitée majoritairement par la pharmacothérapie. Or la thérapie comportementale et cognitive pour l’insomnie présente une meilleure efficacité à long terme que celle-ci. Dans ... [more ▼]

L’insomnie est actuellement traitée majoritairement par la pharmacothérapie. Or la thérapie comportementale et cognitive pour l’insomnie présente une meilleure efficacité à long terme que celle-ci. Dans cet article nous décrivons les principes de base de ce traitement psychothérapeutique de courte durée. Il s’agit de combiner des méthodes de restriction de sommeil, de contrôle des stimuli en lien avec le sommeil, d’apprentissage de techniques de relaxation, des conseils sur l’hygiène de sommeil et des techniques de thérapie cognitive appliquées aux cognitions envahissants les moments d’insomnie. [less ▲]

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See detailInvestigation of a suitable in vitro dissolution test for itraconazole-based solid dispersions
Thiry, Justine ULg; Broze, Guy ULg; Pestieau, Aude ULg et al

in European Journal of Pharmaceutical Sciences (2016)

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See detailMyoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer
Fahmy, Karim ULg; Gonzalez, Arnaud; Arafa, Mohammad et al

in International Journal of Cancer = Journal International du Cancer (2016), 138

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas ... [more ▼]

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis. However, the function of myoferlin in pancreas adenocarcinoma has not been reported. In other cell types, myoferlin is involved in several key plasma membrane processes such as fusion, repair, endocytosis and tyrosine kinase receptor activity. In this study, we showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. In addition to be smaller, the tumors formed by the myoferlin-silenced cells showed a marked absence of functional blood vessels. We further demonstrated that this effect was due, at least in part, to an inhibition of VEGFA secretion by BxPC-3 myoferlin-silenced cells. Using immunofluorescence and electron microscopy, we linked the decreased VEGFA secretion to an impairment of VEGFA exocytosis. The clinical relevance of our results was further strengthened by a significant correlation between myoferlin expression in a series of human pancreatic malignant lesions and their angiogenic status evaluated by the determination of the blood vessel density. [less ▲]

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See detailExperimental study of an oil-free steam piston expander for micro-combined heat and power systems
Bouvier, Jean-Louis; Lemort, Vincent ULg; Michaux, Ghislain et al

in Applied Energy (2016), 1 69

This paper presents an experimental study conducted on an oil-free steam piston expander for micro combined heat and power systems. This expander can produce electrical power (between 740 and 2400 W) with ... [more ▼]

This paper presents an experimental study conducted on an oil-free steam piston expander for micro combined heat and power systems. This expander can produce electrical power (between 740 and 2400 W) with a significant range of supply temperature (between 260 and 340 C) and pressure (between 20 and 34 bar). The expander electrical power output exhibits a fast dynamic response to a change of working or supply fluid conditions. The reached expander overall isentropic efficiency (including electrical generator efficiency) was between 19% and 40%. An empirical model has been developed in order to conduct a sensitivity analysis of the system by varying working variables such as supply and exhaust pressures, rotational speed and supply temperature. The parameters of this model have been identified using experimental results. The sensitivity analysis showed a limited increase of the electrical power output with a rotational speed until 900 rpm and a reduction of the power output for values beyond 900 rpm. It also highlighted the significant positive impact of the supply pressure on the electrical power output and the negative impact of the superheating on the expander overall isentropic efficiency. The obtained results are useful for the future control of the expander integrated into a Rankine cycle. Since the fluid at the expander exhaust is steam at a pressure close to 1 bar, it is possible to produce heat at a temperature close to 80 C, which is sufficient for most domestic applications (heating or direct hot water production). [less ▲]

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See detailVers un modèle d’apprentissage réflexif. Recueil de traces d’apprentissage formulées dans les log books des stagiaires en médecine
Vierset, Viviane ULg

in Approches Inductives : Travail Intellectuel et Construction des Connaissances (2016)

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See detailQuantifying self-consumption linked to solar home battery systems: Statistical analysis and economic assessment
Quoilin, Sylvain ULg; Kavvadias, Konstantinos; Mercier, Arnaud et al

in Applied Energy (2016)

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See detailMagneto-optical trapping of iron atoms
Crauwels, Justine ULg; Huet, Nicolas ULg; Krins, Stéphanie ULg et al

in Belgian Physical Society Magazine (2016), 1

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See detailEfficient standard error formulas of ability estimators with dichotomous item response models
Magis, David ULg

in Psychometrika (2016), 81

This paper focuses on the computation of asymptotic standard errors (ASE) of ability estimators with dichotomous item response models. A general framework is considered and ability estimators are defined ... [more ▼]

This paper focuses on the computation of asymptotic standard errors (ASE) of ability estimators with dichotomous item response models. A general framework is considered and ability estimators are defined from a very restricted set of assumptions and formulas. This approach encompasses most standard methods such as maximum likelihood, weighted likelihood, maximum a posteriori and robust estimators. A general formula for the ASE is derived from the theory of M-estimation. Well-known results are found back as particular cases for the maximum and robust estimators, while new ASE proposals for the weighted likelihood and maximum a posteriori estimators are presented. These new formulas are compared to traditional ones by means of a simulation study under Rasch modeling. [less ▲]

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See detailmTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells.
Grahammer, Florian; Ramakrishnan, Suresh K.; Rinschen, Markus M. et al

in Journal of the American Society of Nephrology : JASN (2016)

Renal proximal tubular cells constantly recycle nutrients to ensure minimal loss of vital substrates into the urine. Although most of the transport mechanisms have been discovered at the molecular level ... [more ▼]

Renal proximal tubular cells constantly recycle nutrients to ensure minimal loss of vital substrates into the urine. Although most of the transport mechanisms have been discovered at the molecular level, little is known about the factors regulating these processes. Here, we show that mTORC1 and mTORC2 specifically and synergistically regulate PTC endocytosis and transport processes. Using a conditional mouse genetic approach to disable nonredundant subunits of mTORC1, mTORC2, or both, we showed that mice lacking mTORC1 or mTORC1/mTORC2 but not mTORC2 alone develop a Fanconi-like syndrome of glucosuria, phosphaturia, aminoaciduria, low molecular weight proteinuria, and albuminuria. Interestingly, proteomics and phosphoproteomics of freshly isolated kidney cortex identified either reduced expression or loss of phosphorylation at critical residues of different classes of specific transport proteins. Functionally, this resulted in reduced nutrient transport and a profound perturbation of the endocytic machinery, despite preserved absolute expression of the main scavenger receptors, MEGALIN and CUBILIN. Our findings highlight a novel mTOR-dependent regulatory network for nutrient transport in renal proximal tubular cells. [less ▲]

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See detailCompte rendu de l’ouvrage de VANACKER Daniël (éd.), Journal d’une bourgeoise, 1914-1918 : Marguerite Giron
Bechet, Christophe ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2016), XXXVIII(1),

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See detailKöppen–Geiger Climate Classification for Europe Recaptured via the Hölder Regularity of Air Temperature Data
Deliège, Adrien ULg; Nicolay, Samuel ULg

in Pure and Applied Geophysics (2016), 173

In this paper, we make use of the monoHölder nature of surface air temperature data to recapture the Köppen–Geiger climate classification in Europe. Using data from the European climate Assessment and ... [more ▼]

In this paper, we make use of the monoHölder nature of surface air temperature data to recapture the Köppen–Geiger climate classification in Europe. Using data from the European climate Assessment and Dataset (ECA&D), we first show that the Ho ̈lder exponents of surface air temperature data are statistically related to pressure anomalies. Then, we establish a climate classification based on these Hölder exponents in such a way that it allows to recover the Ko ̈ppen–Geiger climate classification. We show that the two classifications match for a vast majority of stations, and we corroborate these observations with a confirmation test. We compare these results with those obtained with another dataset (NCEP-NCAR Reanalysis Project) to show that the new classification is still well-adapted, before eventually discussing these findings. [less ▲]

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See detailHow do cumulative live birth rates and cumulative multiple live birth rates over complete courses of assisted reproductive technology treatment per woman compare among registries?
De Neubourg, Diane; Bogaerts, Kris; Blockeel, Christophe et al

in Human Reproduction (2016)

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See detailMechanically-coupled ring-resonator filter and array (analytical and finite element model).
Pachkawade, Vinayak ULg; Junghare, R; Patrikar, R et al

in IET Computers & Digital Techniques (2016)

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band ... [more ▼]

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band-pass filter with centre frequency of 4.4 MHz and a small bandwidth of only 36 kHz. Flexural-mode ring resonators have been mechanically coupled using soft mechanical spring for realising the filtering action. Owing to inherent symmetry in the ring structure, simple approach is used to access a low-velocity coupling locations to set a smallest possible bandwidth. The authors also show a reduction in the amplitude of spurious mode by accentuating the filter structure in its fully differential mode inherently present in the structure. Moreover, the effect of the number of the support beams and structural damping on the frequency response of a filter has been analysed. A second device is mechanically coupled ring-resonator arrays with varying number of rings coupled. The mechanical links using short stubs connect each constituent resonator of an array to its adjacent ones at the high-velocity vibrating locations to accentuate the desired mode and reject all other spurious modes. Both analytical and finite-element based simulation results for parameters of the designed structure are found in good agreement. [less ▲]

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See detailOp zoek naar de grenzen van het mechanisme van correctionalisering. Potpourri II en de spreekwoordelijke olifant
Franssen, Vanessa ULg

in Panopticon : Tijdschrift voor Strafrecht, Criminologie en Forensisch Welzijnswerk (2016)

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See detailThe on-pump/off-pump saga: an enduring conundrum.
Sousa Uva, Miguel; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(4), 1042-3

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See detailA Text Structure Indicator and two Topological Methods: New Ways for Studying Latin Historic Narratives
Longrée, Dominique ULg; Mellet, Sylvie

in DSH: Digital Scholarship in the Humanities (2016)

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See detailHyperuricémie et risque potentiel de pathologie cardiovasculiare et rénale
Schils, Raphaël ULg; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2016)

Besides the well accepted need to treat hyperuricemia associated with gout, some large observational studies and small prospective therapeutic trials have suggested that treating asymptomatic ... [more ▼]

Besides the well accepted need to treat hyperuricemia associated with gout, some large observational studies and small prospective therapeutic trials have suggested that treating asymptomatic hyperuricemia, especially by xanthine oxidase inhibition, the enzyme producing uric acid, could be beneficial for cardiovascular and renal risk prevention. This article discusses the literature about this promising approach, which, however, requests prospective validation. [less ▲]

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See detailVAN LIMBERGHEN, G. (dir.), Misbruik- en fraudebestrijding in het sociaal recht, Anvers, Intersentia, 2015, 269 p.
Kéfer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2016)

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See detailReflectometry with an open-source Software GNSS Receiver. Use Cases with Carrier Phase Altimetry.
Lestarquit, Laurent; Peyrezabes, Mathieu; Darrozes, José et al

in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2016)

An open-source GNSS software receiver allows to have full access to the signal processing and to make add-ons to the source code in order to obtain the desired GNSS reflectometry processing. The direct ... [more ▼]

An open-source GNSS software receiver allows to have full access to the signal processing and to make add-ons to the source code in order to obtain the desired GNSS reflectometry processing. The direct signal is processed in the standard way, its tracking loops replica are tapped to have a robust processing of the reflected signal in a master-slave configuration, with the very same carrier replica used to correlate the reflected signal. Additionally, the data bit sign is wiped off, which allows to extend the coherent integration time (CIT) well beyond the usual 20 milliseconds limit on the reflected way. This allows having a straightforward and accurate measurement of the Amplitude Ratio and Differential Carrier Phase between the direct and reflected signal. The possible applications are precise carrier phase altimetry and any application requiring signal amplitude ratio, or reflected signal Delay Map, with single or dual polarization, this includes code altimetry, humidity, biomass, soil roughness, ocean surface wind and wave height, snow and ice characteristics retrieval. This software is intended to be used as a research tool. It has been tested for carrier phase altimetry on real data sets collected in rather calm water conditions: at the 60 meter Cordouan Lighthouse, and during a 600 meter high ATR42 flight over a lake. In both case, continuous carrier phase measurement with a centimeter level precision were obtained when extending the CIT up to 500 ms. Increasing the CIT beyond 20 ms is the key to improve carrier phase altimetry robustness. [less ▲]

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See detailPredictions of Pinning
Paruch, Patrycja; Ghosez, Philippe ULg

in Nature (2016), 534

A multiscale model has been implemented that provides accurate predictions of the behaviour of ferroelectric materials in electric fields, and might aid efforts to design devices such as sensors and ... [more ▼]

A multiscale model has been implemented that provides accurate predictions of the behaviour of ferroelectric materials in electric fields, and might aid efforts to design devices such as sensors and digital memory. [less ▲]

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See detailEffet inflammatoire des extraits de Cupressus sempervirens planté dans l’Est de l’Algérie : du modèle murin à la stimulation des cellules BEAS-2B par l’allergène majeur Cup s 1
Bouguenoun, Imene; De Pauw-Gillet, Marie-Claire ULg; Bensakhri, Z et al

in Revue Française d'Allergologie (2016), 56

Cupressus sempervirens est l’une des espèces les plus répandues en Algérie ayant une capacité allergénique très élevée. Nous avons étudié,d’abord, comment l’instillation nasale des différentes fractions ... [more ▼]

Cupressus sempervirens est l’une des espèces les plus répandues en Algérie ayant une capacité allergénique très élevée. Nous avons étudié,d’abord, comment l’instillation nasale des différentes fractions de l’extrait pollinique de cette espèce peut moduler la réponse immunitaire chez les souris, et, ensuite, la stimulation des cellules épithéliales bronchiques humaines (BEAS-2B) par l’allergène majeur, identifié par spectrométrie de masse et purifié par chromatographie échangeuse d’ions. La sensibilisation des souris a révélé, d’une part, une diminution du nombre de neutrophiles et une augmentation des éosinophiles, et, d’autre part, une augmentation significative du total cellulaire dans le liquide du lavage bronchoalvéolaire.L’étude histologique des poumons a montré une présence d’infiltrat inflammatoire et d’oedème péri-bronchique. La spectrométrie de masse nous a permis de mettre en évidence la présence de l’allergène majeur Cup s 1 dans toutes les fractions avec une présence spécifique du Cup s 3 et Cupa 1 dans la fraction 4. Cet allergène avait le potentiel pour stimuler la libération de l’IL-8 et l’IL-6 par la ligné cellulaire, BEAS-2B, in vitro d’une manière dose-dépendante [less ▲]

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See detailLymphocytoses B monoclonales : de la revue de la littérature à la pratique de laboratoire.
KEUTGENS, Aurore ULg; Foguenne, Jacques; Gothot, André ULg et al

in Annales de biologie clinique (2016), 74(2), 168-175

Monoclonal B-cell lymphocytosis (MBL) is defined as an asymptomatic condition characterized by the presence of less than 5,000 monoclonal B-cells per microliter and the absence of clinical signs or ... [more ▼]

Monoclonal B-cell lymphocytosis (MBL) is defined as an asymptomatic condition characterized by the presence of less than 5,000 monoclonal B-cells per microliter and the absence of clinical signs or symptoms of a B-cell lymphoproliferative disorder. Most MBL cases involve B cells presenting an identical phenotype to CLL (CLL-like MBL) with a Catovsky-Matutes score of 3 to 5 and share the same chromosomal abnormalities than CLL. Depending on the absolute B cell count, one may distinguish low-count CLL-like MBL (<500 B cells/muL) which have no evidence of progression, no reduction in overall survival, no increase in infection risk and do not require any specific follow-up. Patients with clinical CLL-like MBL (>500 B cells/muL) have a 1% to 2% per year risk of progression to CLL requiring therapy, a higher risk of infectious complications and mortality implicating an annual follow-up by hematologist. MBL may also express other less common phenotypes and are named atypical MBL in case of CD5 antigen expression (Catovsky-Matutes score: 1-2) and non-CLL-like MBL for CD5 negative cases (Catovsky-Matutes score: 0-2). Their poorer prognosis implicates imaging studies, bone marrow biopsy and cytogenetic analysis in addition to physical examination in order to rule out non-hodgkinien lymphoma, and require a more frequent follow-up. This review focuses on key concepts in the classification, diagnosis, monitoring and biology of MBL in laboratory practice. [less ▲]

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See detailExtending abdominal aortic aneurysm detection to older age groups: preliminary results from the Liege screening programme.
MAKRYGIANNIS, Georgios ULg; Labalue, Philippe; Erpicum, Marie ULg et al

in Annals of Vascular Surgery (2016)

BACKGROUND: There is evident benefit in terms of reduced aneurysm related mortality from screening programmes of abdominal aortic aneurysm (AAA) in men aged 65 and more. Recent studies in UK and Sweden ... [more ▼]

BACKGROUND: There is evident benefit in terms of reduced aneurysm related mortality from screening programmes of abdominal aortic aneurysm (AAA) in men aged 65 and more. Recent studies in UK and Sweden have shown a decline of the prevalence of AAA in the general population. Current screening policies (e.g. men aged 65-74 years) however do not account for ageing and increased life expectancy of western populations. This study investigated AAA detection by extending the target population to older age groups (75-85 years). METHODS: AAA screening was conducted in the County of Chaudfontaine (Liege, Belgium) on the population of elderly (N=3,054). The participation rate was 36%. The 1,101 participants (722 men aged 65-85 and 379 women aged 74-85 years) were examined by ultrasound (US) scan. AAA was defined as an infrarenal aortic outer-outer diameter of at least 3 cm. Demographics, clinical parameters and risk factors were also recorded. AAA prevalence was estimated and patients with and without AAA were compared by logistic regression. RESULTS: The overall AAA prevalence was 3.6% (n=40). In female participants, AAA prevalence was low (1.3%). In men, it amounted 2.7% in the 65-74 age group but rose to 7.3% in the age-extended group (75-85 years). Further in addition to age, height, current smoking, history of coronary artery disease, hypercholesterolemia, peripheral artery disease of the lower limbs and varicose veins were significantly associated with the presence of AAA. CONCLUSION: These preliminary findings, based on a representative sample of the elderly population of the Liege region, support the idea that current AAA screening policies should be updated to cover an increasingly ageing population. The presence of varicose veins as a potential risk factor for AAA should also be considered during screening. [less ▲]

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See detailLa "République" de Platon : une leçon de pratique politique ?
Gavray, Marc-Antoine ULg

in Revue Philosophique de Louvain (2016), 115(1), 1-23

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See detailThe development of the abilities to acquire novel detailed orthographic representations and maintain them in long-term memory
Binamé, Florence ULg; Poncelet, Martine ULg

in Journal of Experimental Child Psychology (2016), 143

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained ... [more ▼]

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained variance in the acquisition of word-specific orthographic knowledge that is still underspecified. The main aim of this study was to explore whether two cognitive factors—sensitivity to orthographic regularities and short-term memory (STM) for serial order—make independent contributions to the acquisition of novel orthographic representations beyond that of the phonological core component and the level of preexisting word-specific orthographic knowledge. To this end, we had children from second to sixth grades learn novel written word forms using a repeated spelling practice paradigm. The speed at which children learned the word forms and their long-term retention (1 week and 1 month later) were assessed. Hierarchical regression analyses revealed that phonological recoding, preexisting word-specific orthographic knowledge, and order STM explained a portion of the variance in orthographic learning speed, whereas phonological recoding, preexisting word-specific orthographic knowledge, and orthographic sensitivity each explained a portion of variance in the long-term retention of the newly created orthographic representations. A secondary aim of the study was to determine the developmental trajectory of the abilities to acquire novel orthographic word forms over the course of primary schooling. As expected, results showedan effect of age on both learning speed and long-term retention. The specific roles of orthographic sensitivity and order STM as independent factors involved in different steps of orthographic learning are discussed. [less ▲]

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See detailElectromechanical Sigma-Delta Modulators (EMSDM) force feedback interfaces for capacitive MEMS inertial sensors: a review
Chen, Fang; Li, Xinxin; Kraft, Michael ULg

in IEEE Sensors Journal (2016)

Analog-to-digital converters (ADC) based on sigma-delta modulators (SDM) are a popular choice for high resolution conversion from the analog to the digital domain. With relatively small modifications they ... [more ▼]

Analog-to-digital converters (ADC) based on sigma-delta modulators (SDM) are a popular choice for high resolution conversion from the analog to the digital domain. With relatively small modifications they also can be used as electromechanical SDM (EM-SDM) force feedback interfaces for capacitive micro-electromechanical systems (MEMS) inertial sensors. Such interfaces are able to combine the benefits of force feedback and analog to digital conversion at relatively modest circuit cost. This paper provides a comprehensive review of EM-SDM interfaces for capacitive MEMS inertial sensors. The principle and design methodology of EM-SDM interfaces are introduced. A classification of EM-SDMaccelerometers and gyroscopes is presented, and a detailed analysis of different EM-SDMarchitectures is given. The most representative EM-SDM inertial sensors systems are discussed and compared with regard to their performance characteristics. In particular, the properties of various discrete and continuous-time techniques and a system parameter optimization methodology are illustrated through specific examples. Finally, current challenges and future development trends of EM-SDM interfaces for inertial sensors have been identified. [less ▲]

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See detailAssessing the ability of rural agrarian areas to provide culturalecosystem services (CES): A multi scale social indicator framework(MSIF)
Carvalho-Ribeiro, Sónia; Pinto Correia, Teresa; Paracchini, Maria Luisa et al

in Land Use Policy (2016), 53

Assessing the ways in which rural agrarian areas provide Cultural Ecosystem Services (CES) is provingdifficult to achieve. This research has developed an innovative methodological approach named as ... [more ▼]

Assessing the ways in which rural agrarian areas provide Cultural Ecosystem Services (CES) is provingdifficult to achieve. This research has developed an innovative methodological approach named as MultiScale Indicator Framework (MSIF) for capturing the CES embedded into the rural agrarian areas. Thisframework reconciles a literature review with a transdisciplinary participatory workshop. Both of thesesources reveal that societal preferences diverge upon judgemental criteria which in turn relate to differentvisual concepts that can be drawn from analyzing attributes, elements, features and characteristics of ruralareas. We contend that it is now possible to list a group of possible multi scale indicators for stewardship,diversity and aesthetics. These results might also be of use for improving any existing European indicatorsframeworks by also including CES. This research carries major implications for policy at different levels ofgovernance, as it makes possible to target and monitor policy instruments to the physical rural settingsso that cultural dimensions are adequately considered. There is still work to be developed on regionalspecific values and thresholds for each criteria and its indicator set. In practical terms, by developing theconceptual design within a common framework as described in this paper, a considerable step forwardtoward the inclusion of the cultural dimension in European wide assessments can be made. [less ▲]

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