References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 1501 to 1600 of 56318     11 12 13 14 15 16 17 18 19 20 21     Managing Chronic Kidney Disease in Older People--ReplyGlassock, rj; DELANAYE, Pierre ; El-Nahas, Min JAMA : Journal of the American Medical Association (2016), 315(3), Detailed reference viewed: 4 (1 ULg) Competing effects of volume change and water uptake on the water retention behaviour of a compacted MX-80 bentonite/sand mixtureGatabin, Claude; Talandier, Jean; Collin, Frédéric et alin Applied Clay Science (2016), 121-122Bentonite-based materials have been studied as potential barriers for the geological disposal of radioactive waste. In this context, the hydro-mechanical behaviour of the engineered barrier is first ... [more ▼]Bentonite-based materials have been studied as potential barriers for the geological disposal of radioactive waste. In this context, the hydro-mechanical behaviour of the engineered barrier is first characterized by free swelling conditions (as a consequence of the progressive filling of technological gaps) followed by constant volume conditions. This paper presents an experimental study conducted in order to characterize the water retention behaviour of a compacted MX-80 bentonite/sand mixture. The water retention properties upon wetting were investigated under both free swelling and constant volume conditions. In the high suction range, the water content was not influenced by the imposed volume constraints. On the contrary, swelling significantly affected the water retention behaviour at low suctions, and the quantity of water stored was higher under free swelling conditions than it was under prevented swelling. In this case, competing effects between bentonite swelling and water uptake did not lead to an increase of the degree of saturation upon wetting, as it was observed for samples wetted under constant volume conditions. The influence of the very strong hydro-mechanical coupling is further discussed. [less ▲]Detailed reference viewed: 71 (8 ULg) Frontières, souverainisme et vacuitéGemenne, François in La Revue Nouvelle (2016), 4Detailed reference viewed: 17 (1 ULg) Parsimonious time series clustering using P-splinesIorio, Carmela; Frasso, Gianluca ; D’Ambrosio, Antonio et alin Expert Systems with Applications (2016)Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available ... [more ▼]Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available observations. The measured time series can also be very noisy and sparse and an appropriate model describing them can be hard to define. We propose to model the observed measurements by using P-spline smoothers and then to cluster the functional objects as summarized by the optimal spline coefficients. According to the characteristics of the observed measurements, our proposal can be combined with any suitable clustering method. In this paper we provide applications based on non-hierarchical clustering algorithms. We evaluate the accuracy and the efficiency of our proposal by simulations and by analyzing two real data examples. [less ▲]Detailed reference viewed: 15 (2 ULg) Orbitally induced hierarchy of exchange interactions in zigzag antiferromagnetic state of honeycomb silver delafossite Ag3Co2SbO6Zvereva, E.A.; Stratan, M.I.; Ushakov, A.V. et alin Dalton Transactions (2016)We report the revised crystal structure, static and dynamic magnetic properties of quasi-two dimensional honeycomb lattice silver delafossite Ag3Co2SbO6. The magnetic susceptibility and specific heat data ... [more ▼]We report the revised crystal structure, static and dynamic magnetic properties of quasi-two dimensional honeycomb lattice silver delafossite Ag3Co2SbO6. The magnetic susceptibility and specific heat data are consistent with the onset of antiferromagnetic long range order at low temperatures with Néel temperature TN ~ 21.2 K. In addition, the magnetization curves revealed a field-induced (spin-flop type) transition below TN in moderate magnetic fields. The GGA+U calculations show the importance of the orbital degrees of freedom, which maintain a hierarchy of exchange interaction in the system. The strongest antiferromagnetic exchange coupling was found in the shortest Co-Co pairs and is due to direct and superexchange interaction between the half-filled xz+yz orbitals pointing directly to each other. The other four out of six nearest neighbor exchanges within the cobalt hexagon are suppressed, since for these bonds active half-filled orbitals turned out to be parallel and do not overlap. The electron spin resonance (ESR) spectra reveal a broad absorption line attributed to Co2+ ion in octahedral coordination with average effective g-factor g=2.40±0.05 at room temperature and show strong divergence of ESR parameters below ~ 150 K, which implies an extended region of short-range correlations. Based on the results of magnetic and thermodynamic studies in applied fields, we propose the magnetic phase diagram for the new honeycomb-lattice delafossite. [less ▲]Detailed reference viewed: 37 (5 ULg) Isolation and characterization of Ts19 Fragment II, a new long-chainpotassium channel toxin from Tityus serrulatus venomCerni, Felipe Augusto; Pucca, Manuela Berto; Amorim, Fernanda Gobbi et alin Peptides (2016), 80Ts19 Fragment II (Ts19 Frag-II) was first isolated from the venom of the scorpion Tityus serrulatus (Ts). It is aprotein presenting 49 amino acid residues, three disulfide bridges, Mr5534 Da and was ... [more ▼]Ts19 Fragment II (Ts19 Frag-II) was first isolated from the venom of the scorpion Tityus serrulatus (Ts). It is aprotein presenting 49 amino acid residues, three disulfide bridges, Mr5534 Da and was classified as a newmember of class (subfamily) 2 of the -KTxs, the second one described for Ts scorpion. The -KTx familyis composed by two-domain peptides: N-terminal helical domain (NHD), with cytolytic activity, and aC-terminal CS domain (CCD), with Kv blocking activity. The extensive electrophysiological screening(16 Kv channels and 5 Nav channels) showed that Ts19 Frag-II presents a specific and significant blockingeffect on Kv1.2 (IC50value of 544 ± 32 nM). However, no cytolytic activity was observed with this toxin.We conclude that the absence of 9 amino acid residues from the N-terminal sequence (compared to Ts19Frag-I) is responsible for the absence of cytolytic activity. In order to prove this hypothesis, we synthesizedthe peptide with these 9 amino acid residues, called Ts19 Frag-III. As expected, Ts19 Frag-III showed tobe cytolytic and did not block the Kv1.2 channel. The post-translational modifications of Ts19 and itsfragments (I–III) are also discussed here. A mechanism of post-translational processing (post-splitting) issuggested to explain Ts19 fragments production. In addition to the discovery of this new toxin, this reportprovides further evidence for the existence of several compounds in the scorpion venom contributing tothe diversity of the venom arsenal. [less ▲]Detailed reference viewed: 18 (3 ULg) The morphology of the mandibular coronoid process does not indicate that Canis lupus chanco is the progenitor to dogsJanssens, Luc; Miller, Rebecca ; Van Dongen, Stefanin Zoomorphology (2016)The domestication of wolves is currently under debate. Where, when and from which wolf sub-species dogs originated are being investigated both by osteoarchaeologists and geneticists. While DNA research is ... [more ▼]The domestication of wolves is currently under debate. Where, when and from which wolf sub-species dogs originated are being investigated both by osteoarchaeologists and geneticists. While DNA research is rapidly becoming more active and popular, morphological methods have been the gold standard in the past. But even today morphological details are routinely employed to discern archaeological wolves from dogs. One such morphological similarity between Canis lupus chanco and dogs was published in 1977 by Olsen and Olsen. This concerns the ‘‘turned back’’ anatomy of the dorsal part of the vertical ramus of the mandible that was claimed to be specific to domestic dogs and Chinese wolves C. lupus chanco, and ‘‘absent from other canids’’. Based on this characteristic, C. lupus chanco was said to be the progenitor of Asian and American dogs, and this specific morphology has been continuously used as an argument to assign archaeological specimens, including non-Asian and on-American, to the dog clade. We challenged this statement by examining 384 dog skulls of 72 breeds and 60 skulls of four wolf subspecies. Only 20 % of dog mandibles and 80 % of C. lupus chanco showed the specific anatomy. In addition, 12 % of Canis lupus pallipes mandibles howed the ‘‘turned back’’ morphology. It can be concluded that the shape of the coronoid process of the mandible cannot be used as a morphological trait to determine whether a specimen belongs to a dog or as an argument in favour of chanco as the progenitor to dogs. [less ▲]Detailed reference viewed: 10 (1 ULg) Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signsBaise, Etienne ; Habyarimana, Jean ; Amory, Hélène et alin Equine Veterinary Journal (2016)Detailed reference viewed: 90 (35 ULg) Working Memory Assessment: Construct Validity of the Brown-Peterson TestGeurten, Marie ; Vincent, Eric ; Van der Linden, Martial et alin Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2016), 48(4), 328-336The classical Brown-Peterson task is generally supposed to assess working memory capacities. To date, however, the construct validity of the task remains mostly unexamined. In this context, the aim of the ... [more ▼]The classical Brown-Peterson task is generally supposed to assess working memory capacities. To date, however, the construct validity of the task remains mostly unexamined. In this context, the aim of the present study was to demonstrate the convergent and the divergent validity as well as the clinical and the developmental sensitivity of a computerized version of the Brown-Peterson test. A group of 726 French-speaking participants aged from 18 to 86 years and 47 patients who had sustained a traumatic brain injury (TBI) were administered the Brown-Peterson task and various other cognitive tasks assessing executive functioning, verbal and visual memory, or processing speed. The correlation analyses revealed the good convergent of the task, which was shown to be able to distinguish between participants with TBI and control participants. We found an effect of age and education level on the different scores recorded for the Brown-Peterson test. Normative data taking into account the influence of the latter variables were thus provided. On the whole, these findings seem to confirm the validity of the Brown-Peterson task as a tool to assess working memory abilities. [less ▲]Detailed reference viewed: 100 (9 ULg) High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA StudyEdwards, M.H.; Parsons, C.; Bruyère, Olivier et alin Journal of Rheumatology (2016), 43(3), 657-65Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change ... [more ▼]Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW). Methods. A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression. Results. The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β = –0.10 (95% CI –0.18, –0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW. Conclusion. The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade. (First Release January 15 2016; J Rheumatol 2016;43:657–65; doi:10.3899/jrheum.150053) [less ▲]Detailed reference viewed: 30 (6 ULg) Organizaciones regionales y diversidad cultural: la diplomacia de la Unión Europea con el Mercosur entre la sombra de Hollywood y la acción intergubernamentalVlassis, Antonios in Cuadernos de Información y Comunicación (2016), 21Abstract. The aim of the article is double: on the one hand, to explore the EU’s ability to conduct a foreign audiovisual policy towards the Mercosur region and to promote the norms of the Convention on ... [more ▼]Abstract. The aim of the article is double: on the one hand, to explore the EU’s ability to conduct a foreign audiovisual policy towards the Mercosur region and to promote the norms of the Convention on diversity of cultural expressions; on the other hand, to analyze the impact of the EU audiovisual policy model on the development of the Mercosur audiovisual cooperation and to focus on the main forces shaping the Mercosur audiovisual landscape. The article seeks to emphasize why and how the EU pursues an audiovisual foreign policy towards the Mercosur region, for which purposes as well as to highlight the resistances. In this sense, it is more concerned with understanding how the EU’s audiovisual diplomacy interplays with other main factors, such as the governmental action, namely the EU and Mercosur members’ audiovisual diplomacy and the practices of private sector (Hollywood and big media conglomerates). [less ▲]Detailed reference viewed: 11 (0 ULg) The leaf extract of Ribes nigrum L. is a potent stimulator of the endothelial formation of NO in cultured endothelial cells and porcine coronary artery ringsTabart, Jessica; Schini-Kerth, Valérie; PINCEMAIL, Joël et alin Journal of Berry Research (2016), 6BACKGROUND: Endothelial dysfunction is a major hallmark of most types of cardiovascular diseases. Numerous plant extracts have been shown to cause endothelium-dependent relaxations by increasing the ... [more ▼]BACKGROUND: Endothelial dysfunction is a major hallmark of most types of cardiovascular diseases. Numerous plant extracts have been shown to cause endothelium-dependent relaxations by increasing the endothelial formation of the potent vasoprotective factor, nitric oxide (NO). OBJECTIVE: The ability of different Ribes nigrum L. extracts (Grossulariaceae) to induce endothelium-dependent relaxation by stimulating the endothelial formation of NO was assesssed. METHODS: Ribes nigrum extracts were prepared from buds, berries and leaves by extraction (Acetone:H2O:Acetic Acid; 70/28/2 (v/v/v)) and lyophilized after acetone evaporation. The ability of the extracts to stimulate the endothelial formation of NO was assessed using cultured endothelial cells and isolated porcine coronary artery rings. RESULTS: The Ribes nigrum leaf extract increased to a greater extent than the bud and the berry extracts the formation of NO, and up-regulated eNOS mRNA expression in cultured endothelial cells (the stimulatory effects amounted to 197 ± 9 %, 134 ± 6 % and 118 ± 5 %, respectively). The leaf extract induced greater relaxations of isolated coronary arteries with endothelium than the bud and the berry extracts whereas no such effects were observed in rings without endothelium. Relaxations to the leaf extract were minimally affected by indomethacin and by inhibitors of endothelium-dependent hyperpolarization response, and markedly reduced by NG-nitro-L-arginine. CONCLUSIONS: The present findings indicate that the Ribes nigrum leaf extract is a more potent inducer of the endothelial formation of NO than the bud and the berry extracts. [less ▲]Detailed reference viewed: 21 (4 ULg) Quality of documentation on antibiotic therapy in medical records: evaluation of combined interventions in a teaching hospital by repeated point prevalence survey.VERCHEVAL, Christelle ; Gillet, Marie-Claire ; MAES, Nathalie et alin European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology (2016), 35(9), 14951500This study aimed to improve the quality of documentation on antibiotic therapy in the computerized medical records of inpatients. A prospective, uncontrolled, interrupted time series (ITS) study was ... [more ▼]This study aimed to improve the quality of documentation on antibiotic therapy in the computerized medical records of inpatients. A prospective, uncontrolled, interrupted time series (ITS) study was conducted by repeated point prevalence survey (PPS) to audit the quality of documentation on antibiotic therapy in the medical records before and after a combined intervention strategy (implementation of guidelines, distribution of educational materials, educational outreach visits, group educational interactive sessions) from the antimicrobial stewardship team (AST) in the academic teaching hospital (CHU) of Liege, Belgium. The primary outcome measure was the documentation rate on three quality indicators in the computerized medical records: (1) indication for treatment, (2) antibiotics prescribed, and (3) duration or review date. Segmented regression analysis was used to analyze the ITS. The medical records of 2306 patients receiving antibiotics for an infection (1177 in the pre-intervention period and 1129 in the post-intervention period) were analyzed. A significant increase in mean percentages in the post-intervention period was observed as compared with the pre-intervention period for the three quality indicators (indication documented 83.4 +/- 10.4 % vs. 90.3 +/- 6.6 %, p = 0.0013; antibiotics documented 87.9 +/- 9.0 % vs. 95.6 +/- 5.1 %, p < 0.0001; and duration or review date documented 31.9 +/- 15.4 % vs. 67.7 +/- 15.2 %, p < 0.0001). The study demonstrated the successful implementation of a combined intervention strategy from the AST. This strategy was associated with significant changes in the documentation rate in the computerized medical records for the three quality indicators. [less ▲]Detailed reference viewed: 12 (7 ULg) Photocatalytic decomposition of hydrogen peroxide over nanoparticles of TiO2 and Ni(II)-porphyrin doped TiO2: a relationship between activity and porphyrin anchoring modeTasseroul, Ludivine ; Pàez Martinez, Carlos ; Lambert, Stéphanie et alin Applied Catalysis B : Environmental (2016), 182The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared ... [more ▼]The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared spectroscopy and thermal gravimetry combined with differential scanning calorimetry measurements allowed the determination of the TCPPNi anchoring mode. At low TCPPNi concentrations, this anchoring on Degussa P25 TiO2 took place through all four carboxylic groups, while at higher concentrations the anchoring occurred through one or two carboxylic groups. For the firsttime,the effect of UV/vis light irradiation on the H2O2-degradation activity of TiO2 and TCPPNi-doped TiO2 was studied using the method of following the production of O2 by gas pressure monitoring. The activity of seven different catalysts was related to the TCPPNi anchoring mode and the percentage of TiO2 Degussa P25 coverage. An optimum degradation of H2O2 was observed for 0.0115 mol TCPPNi × g−1 P25. In that case, the TCPPNi was anchored through the four carboxylic groups, corresponding to a strong interaction with Degussa P25 TiO2. Moreover, the TCPPNi did not cover the surface completely, therefore allowing the light to reach and activate the TiO2. [less ▲]Detailed reference viewed: 59 (12 ULg) L’adaptation du pervers et du psychopathe : compréhension phénoménologique et éthologiqueEnglebert, Jérôme in PSN. Psychiatrie, Sciences Humaines, Neurosciences (2016), 16Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have ... [more ▼]Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have to note that there are moments of mismatch and maladjustment. These ‘‘perverse moments’’ are very important to be observed and regarded as a pathognomonic symptomatology. The specificity of the perverse functioning should be viewed as a continuum of adaptation along which an individual may pass from ‘‘hyperadaptation’’ on the one hand, to moments of failures and mis-adapting on the other hand. Then, we propose a comparison between the binswangerian conception of mania and the psychopathic functioning. The maniac has a fundamental crisis of the ‘‘ego’’, which the psychopath does not have. A second finding of our investigations concerns emotions and the dimension of the adaptive psychopathic disorder. The last point we discuss is about the concepts of empathy and sympathy. Finally, a significant part of this paper is to propose a differentiation concerning adaptive behaviour: one is more social (the pervert); the other is more solitary (the psychopath). [less ▲]Detailed reference viewed: 35 (2 ULg) High resolution characterization of the soil organic carbon depth profile in a soil landscape affected by erosionJague, Emilien; Sommer, Michael; Saby, Nicolas et alin Soil & Tillage Research (2016), 156Detailed reference viewed: 41 (5 ULg) Volcanic eruptions boost tropical Pacific biological productivityChikamoto, Megumi O.; Timmermann, Axel; Yoshimori, Masakazu et alin Geophysical Research Letters (2016), 43Detailed reference viewed: 13 (0 ULg) 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretionPirotte, Bernard ; Florence, X; Goffin, Eric et alin European Journal of Medicinal Chemistry (2016), 121Detailed reference viewed: 15 (5 ULg) Use of donor milk in the neonatal intensive care unitde halleux, Virginie; Pieltain, Catherine; SENTERRE, Thibault et alin Seminars in Fetal & Neonatal Medicine (2016)Detailed reference viewed: 12 (2 ULg) Calf health: Cholesterol deficiency causing calf illthrift and diarrhoeaDuff, J. P.; Passant, S.; Wessels, M. et alin The Veterinary record (2016), 178(17), 424-5Detailed reference viewed: 23 (4 ULg) Importance of the reconciliation method to handle experimental data in refrigeration and power cycle: application to a reversible heat pump/organic Rankine cycle unit integrated in a positive energy buildingDumont, Olivier ; Quoilin, Sylvain ; Lemort, Vincent in International Journal of Energy and Environmental Engineering (2016)Detailed reference viewed: 21 (3 ULg) Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing processHarrouche, K; Renard, JF; Bouider, N et alin European Journal of Medicinal Chemistry (2016), 115Detailed reference viewed: 24 (9 ULg) An ecophysiological discussion of trace element bioaccumulation in cultured Mytilus galloprovincialisRichir, Jonathan ; Gobert, Sylvie in Belgian Journal of Zoology (2016), 145(1), 53-61Detailed reference viewed: 28 (6 ULg) Partial ages: diagnosing transport processes by means of multiple clocks.Mouchet, Anne ; Cornaton, Fabien; Deleersnijder, Eric et alin Ocean Dynamics (2016), 66Detailed reference viewed: 42 (7 ULg) The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.Cao, Martine ; Royce, Darlene B.; Risingsong, Renee et alin Cancer prevention research (Philadelphia, Pa.) (2016), 9(1), 105-14LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both ... [more ▼]LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both drugs are useful for prevention of lung cancer in A/J mice. These molecules markedly reduced tumor number, tumor size, and total tumor burden, when chronically administered to A/J mice that had been initiated with the mutagenic carcinogen, vinyl carbamate. Moreover, LG100268 synergized with the histone deacetylase inhibitor, vorinostat, for prevention of experimental lung cancer and enhanced the effect of carboplatin/paclitaxel for treatment of experimental lung cancer. Both rexinoids diminished the percentage of high-grade, highly malignant adenocarcinomas found at autopsy. In cell culture studies, the rexinoids exhibited potent anti-inflammatory properties at nanoMolar concentrations. These drugs suppressed the ability of lipopolysaccharide to stimulate the synthesis and secretion of nitric oxide and inflammatory cytokines and chemokines, such as IL6, IL1beta, CXCL2, and CSF3, in macrophage-like RAW264.7 cells. The present results suggest that LG100268, LG101506, or a related rexinoid may have useful clinical applications in the field of oncology. Cancer Prev Res; 9(1); 105-14. (c)2015 AACR. [less ▲]Detailed reference viewed: 24 (3 ULg) The Calern Asteroid Polarimetric Survey using the Torino Polarimeter: assessment of instrument performances and first scientific resultsDevogele, Maxime ; Cellino, Alberto; Bagnulo, Stefano et alin Monthly Notices of the Royal Astronomical Society (2016)A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the Observatoire de la C ... [more ▼]A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the Observatoire de la C{\^o}te d'Azur''. Its main purpose is to carry out a polarimetric survey of Solar System objects. This survey is called CAPS (Calern Asteroid Polarimetric Survey). In this paper, the new Torino polarimeter (ToPo) and its preliminary validation campaign is described. The first results of the CAPS survey are also presented. A number of standard stars with known polarization states, as well as a number of asteroids for which the polarimetric properties are known, have been observed in order to assess the instrument accuracy. The instrument response over the field of view and also its stability over single nights and longer periods have also been tested. It has been found that the instrument polarization is stable within a few $10^{-4}$ units. The first polarimetric observations of a still limited number of asteroids show an excellent agreement with previously available data and make already some significant contributions by adding new data to a number of objects that had been poorly observed so far. [less ▲]Detailed reference viewed: 40 (3 ULg) P.Bour. 1 (P.Sorb. inv. 826 = MP³ 2643) : reconstruction codicologiqueCarlig, Nathan in Zeitschrift für Papyrologie und Epigraphik (2016), 198Based on the autopsy of the 11 folios of P.Bour. 1, the article identifies the original form of this school book, that is a series of 4 biniones, of which only the 1st and the 3rd are entirely kept. The ... [more ▼]Based on the autopsy of the 11 folios of P.Bour. 1, the article identifies the original form of this school book, that is a series of 4 biniones, of which only the 1st and the 3rd are entirely kept. The survey was pursued with the study of rests of binding and of the state os preservation of each folio. [less ▲]Detailed reference viewed: 22 (3 ULg) The combined mechanism of bone morphogenetic protein- and calcium phosphate-induced skeletal tissue formation by human periosteum derived cells.Bolander, J.; Ji, W.; Geris, Liesbet et alin European Cells and Materials (2016), 31When combining osteogenic progenitor cells such as human periosteum derived cells (hPDCs) with osteoconductive biomaterials like calcium phosphate (CaP)-scaffolds, in vivo bone formation can be achieved ... [more ▼]When combining osteogenic progenitor cells such as human periosteum derived cells (hPDCs) with osteoconductive biomaterials like calcium phosphate (CaP)-scaffolds, in vivo bone formation can be achieved. This process is dependent on the early activation of Bone morphogenetic protein (BMP)-signalling. However, the bone forming process is slow and routinely only a limited amount of bone and bone marrow is formed. Therefore, we hypothesised that a robust clinically relevant outcome could be achieved by adding more physiological levels of potent BMP-ligands to these cell- and CaP-based constructs. For this, hPDCs were characterised for their responsiveness to BMP-ligands upon in vitro 2D stimulation. BMP-2, -4, -6 and -9 robustly induced osteochondrogenic differentiation. Subsequently, these ligands were coated onto clinically approved CaP-scaffolds, BioOss(R) and CopiOs(R), followed by hPDC-seeding. Protein lysates and conditioned media were investigated for activation of BMP signalling pathways. Upon in vivo implantation, the most abundant bone formation was found in BMP-2 and BMP-6-coated scaffolds. Implanted cells actively contributed to the newly formed bone. Remnants of cartilage could be observed in BMP-coated CopiOs(R)-constructs. Computational analysis displayed that the type of BMP-ligand as well as the CaP-scaffold affects skeletal tissue formation, observed in a qualitative as well as quantitative manner. Furthermore, the in vitro mechanism appears to predict the in vivo outcome. This study presents further evidence for the potential of BMP-technology in the development of clinically relevant cell-based constructs for bone regenerative strategies. [less ▲]Detailed reference viewed: 11 (2 ULg) The Added-value of Using Participatory Approaches to Assess the Acceptability of Surveillance Systems: The Case of Bovine Tuberculosis in BelgiumCalba, C; Goutard, FL; Vanholme, L et alin PLoS ONE (2016), 11(7), 0159041Detailed reference viewed: 11 (3 ULg) Unravelling the mechanisms of a protein refolding process based on the association of detergents and co-solvents.Michaux, Catherine; Roussel, Guillaume; Lopes-Rogrigues, M. et alin Journal of peptide science : an official publication of the European Peptide Society (2016)A new technique associating the detergent Sodium Dodecyl Sulphate (SDS) and an alcohol-type co-solvent has been set up, showing an unexpected efficiency to refold several types of soluble or membrane ... [more ▼]A new technique associating the detergent Sodium Dodecyl Sulphate (SDS) and an alcohol-type co-solvent has been set up, showing an unexpected efficiency to refold several types of soluble or membrane proteins. The present contribution deepens the fundamental knowledge on the phenomena underlying this process, considering the refolding of two model peptides featuring the main protein secondary structures: alpha-helix and beta-sheet. Their refolding was monitored by fluorescence and circular dichroism, and it turns out that: (i) 100% recovery of the folded structure is observed for both peptides, (ii) the highest the SDS concentration, the more co-solvent to be added to recover the peptides' native structures, (iii) a high alcohol concentration is required to alter the SDS denaturing properties, (iv) the co-solvent performance relies on its specific lipophilic-hydrophilic balanced character, (v) the size of the micelle formed by the detergent does not enter the process critical parameters, and (vi) increasing the salt concentration up to 1 M NaCl has a beneficial impact on the process efficiency. These mechanistic aspects will help us to improve the method and extend its application. Copyright (c) 2016 European Peptide Society and John Wiley & Sons, Ltd. [less ▲]Detailed reference viewed: 27 (5 ULg) Concordance between iohexol and iothalamate plasma clearanceDELANAYE, Pierre ; JOURET, François ; LE GOFF, Caroline et alin American Journal of Kidney Diseases (2016)Detailed reference viewed: 17 (3 ULg) Association Between Necropsy Evidence of Disseminated Intravascular Coagulation and Hemostatic Variables Before Death in Horses With Colic.Cesarini Latorre, Carlota ; Cotovio, M.; Rios, J. et alin Journal of veterinary internal medicine / American College of Veterinary Internal Medicine (2016), 30(1), 269-75BACKGROUND: Disseminated intravascular coagulation (DIC) is frequent in horses with severe gastrointestinal disorders. Postmortem studies have found fibrin microthrombi in tissues of these horses, but ... [more ▼]BACKGROUND: Disseminated intravascular coagulation (DIC) is frequent in horses with severe gastrointestinal disorders. Postmortem studies have found fibrin microthrombi in tissues of these horses, but studies relating these histopathological findings with antemortem hemostatic data are lacking. HYPOTHESIS: Antemortem classification of coagulopathy is related to the presence and severity of fibrin deposits observed postmortem in horses with severe gastrointestinal disorders. ANIMALS: Antemortem hemostatic profile data and postmortem tissue samples (kidney, lung, liver) from 48 horses with colic. METHODS: Tissue samples were stained with phosphotungstic acid hematoxylin and immunohistochemical methods for histological examination. A fibrin score (grades 0-4) was assigned for each technique, tissue and horse, as well as the presence or absence of DIC at postmortem examination. D-dimer concentration, prothrombin time (PT), activated partial thromboplastin time (aPTT), and antithrombin (AT) activity, as well as the clinicopathological evidence of coagulopathy, were determined from plasma samples collected 0-24 hours before death or euthanasia. Histologic and clinicopathologic data from the same horses were compared retrospectively. RESULTS: No association was found between antemortem classification of coagulopathy and postmortem diagnosis of DIC based on tissue fibrin deposition. None of the hemostatic parameters was significantly different between horses with or without postmortem diagnosis of DIC. There was no association between horses with fibrin in tissues or different cut-offs for D-dimer concentration and postmortem evidence of DIC. CONCLUSIONS AND CLINICAL IMPORTANCE: Abnormalities of the routine clotting profile, including D-dimer concentration, were not useful in predicting histologic evidence of DIC at necropsy in horses with severe gastrointestinal disorders. [less ▲]Detailed reference viewed: 9 (1 ULg) The value of a safe, connected social climate for adolescents girls in residential careLanctôt, Nadine; Lemieux, Annie; Mathys, Cécile in Residential Treatment for Children & Youth (2016)This article described adolescent girls’ (n = 153) perceptions of the social climate that prevailed in their residential care unit and explored to what extent these perceptions related to their ... [more ▼]This article described adolescent girls’ (n = 153) perceptions of the social climate that prevailed in their residential care unit and explored to what extent these perceptions related to their pretreatment individual characteristics. Social climate was examined with a gender-responsive approach and through empathetic interactions with practitioners, healthy connections with the peer group, and just and collaborative practices within the residential care setting. Results indicated that adolescent girls’ configuration of risks and needs impact how they perceive their program environment. We conclude the article with specific recommendations for enhancing gender-responsive programs in residential care setting in regard to non-programmatic features. [less ▲]Detailed reference viewed: 13 (1 ULg) Selection of a discriminant and biorelevant in vitro dissolution test for the development of fenofibrate self-emulsifying lipid-based formulationsPestieau, Aude ; Krier, Fabrice; Brouwers, Adeline et alin European Journal of Pharmaceutical Sciences (2016)Detailed reference viewed: 21 (9 ULg) Modeling heat stress under different environmental conditionsCarabano, Maria-Jesus; Logar, Betka; Bormann, Jeanne et alin Journal of Dairy Science (2016)Renewed interest in heat stress effects on livestock productivity derives from climate change, which is expected to increase temperatures and the frequency of extreme weather events. This study aimed at ... [more ▼]Renewed interest in heat stress effects on livestock productivity derives from climate change, which is expected to increase temperatures and the frequency of extreme weather events. This study aimed at evaluating the effect of temperature and humidity on milk production in highly selected dairy cattle populations across three European regions differing in climate and production systems to detect differences and similarities that can be used to optimize heat stress (HS) effect modeling. Milk, fat and protein test day data from official milk recording for years 1999 to 2010 in four Holstein populations located in the Walloon Region of Belgium (BEL), Luxembourg (LUX), Slovenia (SLO) and Southern Spain (SPA) were merged with temperature and humidity data provided by the state meteorological agencies. After merging, the number of test day records/cows per trait ranged from 686,726/49,655 in SLO to 1,982,047/136,746 in BEL. Values for the daily average and maximum temperature and humidity index (THIavg and THImax) ranges for THIavg/THImax were largest in SLO (22-74/28-84) in SLO and shortest in SPA (39-76/46-83). Change point techniques were used to determine comfort thresholds, which differed across traits and climatic regions. Milk yield showed an inverted U shaped pattern of response across the THI scale with a HS threshold around 73 THImax units. For fat and protein, thresholds were lower than for milk yield and were shifted around 6 THI units towards larger values in SPA compared with the other countries. Fat showed lower HS thresholds than protein traits in all countries. The traditional broken line model was compared to quadratic and cubic fits of the pattern of response in production to increasing heat loads. A cubic polynomial model allowing for individual variation in patterns of response and THIavg as heat load measure showed the best statistical features. Higher/lower producing animals showed less/more persistent production (quantity and quality) across the THI scale. The estimated correlations between comfort and THIavg values of 70 (which represents the upper end of the THIavg scale in BEL-LUX) were lower for BEL-LUX (0.70 - 0.80) than for SPA (0.83 - 0.85). Overall, animals producing in the more temperate climates and semi-extensive grazing systems of BEL and LUX showed HS at lower heat loads and more re-ranking across the THI scale than animals producing in the warmer climate and intensive indoor system of SPA. [less ▲]Detailed reference viewed: 105 (20 ULg) A Mixed Integer Programming formulation for the three dimensional bin packing problem deriving from an air cargo applicationPaquay, Célia ; Schyns, Michael ; Limbourg, Sabine in International Transactions in Operational Research (2016), 23(1-2), 187-213The present paper looks into the problem of optimising the loading of boxes into containers. The goal is to minimise the unused volume. This type of problem belongs to the family of Multiple Bin Size Bin ... [more ▼]The present paper looks into the problem of optimising the loading of boxes into containers. The goal is to minimise the unused volume. This type of problem belongs to the family of Multiple Bin Size Bin Packing Problems. The approach includes an extensive set of constraints encountered in real-world applications in the three-dimensional case: the stability, the fragility of the items, the weight distribution and the possibility to rotate the boxes. It also includes the specific situation in which containers are truncated parallelepipeds. This is typical in the field of air transportation. While most papers on cutting and packing problems describe ad-hoc procedures, this paper proposes a mixed integer linear program. The validity of this model is tested on small instances. [less ▲]Detailed reference viewed: 209 (56 ULg) Long-term analysis of rainfall and temperature data in Burkina Faso (1950–2013)De Longueville, Florence; Hountondji, Yvon-Carmen; Kindo, Issa et alin International Journal of Climatology (2016)Detailed reference viewed: 67 (12 ULg) Coupling curvature-dependent and shear stress-stimulated neotissue growth in dynamic bioreactor cultures: a 3D computational model of a complete scaffold.Guyot, Y.; Papantoniou, I.; Luyten, F. P. et alin Biomechanics & Modeling in Mechanobiology (2016), 15(1), 169-80The main challenge in tissue engineering consists in understanding and controlling the growth process of in vitro cultured neotissues toward obtaining functional tissues. Computational models can provide ... [more ▼]The main challenge in tissue engineering consists in understanding and controlling the growth process of in vitro cultured neotissues toward obtaining functional tissues. Computational models can provide crucial information on appropriate bioreactor and scaffold design but also on the bioprocess environment and culture conditions. In this study, the development of a 3D model using the level set method to capture the growth of a microporous neotissue domain in a dynamic culture environment (perfusion bioreactor) was pursued. In our model, neotissue growth velocity was influenced by scaffold geometry as well as by flow- induced shear stresses. The neotissue was modeled as a homogenous porous medium with a given permeability, and the Brinkman equation was used to calculate the flow profile in both neotissue and void space. Neotissue growth was modeled until the scaffold void volume was filled, thus capturing already established experimental observations, in particular the differences between scaffold filling under different flow regimes. This tool is envisaged as a scaffold shape and bioprocess optimization tool with predictive capacities. It will allow controlling fluid flow during long-term culture, whereby neotissue growth alters flow patterns, in order to provide shear stress profiles and magnitudes across the whole scaffold volume influencing, in turn, the neotissue growth. [less ▲]Detailed reference viewed: 7 (0 ULg) The mass of the very massive binary WR21aTramper, F.; Sana, H.; Fitzsimons, N. E. et alin Monthly Notices of the Royal Astronomical Society (2016)We present multi-epoch spectroscopic observations of the massive binary system WR21a, which include the 2011 January periastron passage. Our spectra reveal multiple SB2 lines and facilitate an accurate ... [more ▼]We present multi-epoch spectroscopic observations of the massive binary system WR21a, which include the 2011 January periastron passage. Our spectra reveal multiple SB2 lines and facilitate an accurate determination of the orbit and the spectral types of the components. We obtain minimum masses of 64.4±4.8 Msun and 36.3±1.7 Msun for the two components of WR21a. Using disentangled spectra of the individual components, we derive spectral types of O3/WN5ha and O3Vz ((f*)) for the primary and secondary, respectively. Using the spectral type of the secondary as an indication for its mass, we estimate an orbital inclination of i=58.8±2.5° and absolute masses of 103.6±10.2 Msun and 58.3±3.7 Msun, in agreement with the luminosity of the system. The spectral types of the WR21a components indicate that the stars are very young (1–2 Myr), similar to the age of the nearby Westerlund 2 cluster. We use evolutionary tracks to determine the mass–luminosity relation for the total system mass. We find that for a distance of 8 kpc and an age of 1.5 Myr, the derived absolute masses are in good agreement with those from evolutionary predictions. [less ▲]Detailed reference viewed: 11 (0 ULg) A Simple Tiered Methodology for the Determination of Ambient Air Quality GuidelinesPIRARD, Catherine ; Brouhon, Jean-Marc; Fourmeaux, Annick et alin Clean : Soil, Air, Water (2016), 44Detailed reference viewed: 16 (4 ULg) Palynology and ostracodology at the Roman port of ancient Ostia (Rome, Italy)Sadori, Laura; Mazzini, Ilaria; Pepe, Caterina et alin Holocene (2016), 26(9), 1502-1512New detailed palynological and ostracodological analyses together with texture data from a sediment core drilled in Ostia Antica confirm the existence of the ancient Ostia harbour and its location by the ... [more ▼]New detailed palynological and ostracodological analyses together with texture data from a sediment core drilled in Ostia Antica confirm the existence of the ancient Ostia harbour and its location by the Tiber River. Using the different proxies analysed in this work and chronologically framing the sediment record with three AMS radiocarbon dates, four phases have been singled out: pre-harbour, harbour bay under fluvial influence, more protected harbour basin and post-harbour phase. Ostracodology is used to reconstruct the marine versus freshwater influence in the basin. Palynology is used to reconstruct the plant landscape and the surrounding environment. Phases with low pollen concentration and expansions of NPPs suggest soil erosion and are alternated with quieter ones, where human impact was very clear. Deciduous oaks typical of coastal plain forests are the main taxon during the harbour phases. The occurrence of riparian trees increases in periods with low pollen concentration, high NPPs and very high pine percentages. These should be the periods in which important sediment inputs inside the harbour basin arrived and could be the expression of intense flooding phases. The comparison between the ostracod assemblages recovered in the two cores and has led to speculate a complex harbour structure. A separation could explain the micropalaeontological differences between the cores. Thus, we suggest that a pier must have been built in order to protect the inner harbour from the marine influence and to unload the goods transported by the big ships. [less ▲]Detailed reference viewed: 9 (1 ULg) Manipulation et mobilisation en cas de cervicalgieDemoulin, Christophe in Cochrane (2016)Detailed reference viewed: 42 (2 ULg) Blowing a liquid curtainLhuissier, Henri; Brunet, Philippe; Dorbolo, Stéphane in Journal of Fluid Mechanics (2016), 795Detailed reference viewed: 23 (5 ULg) Compte-redu de l'ouvrage de Mònica Fuertes : La sátira política en la primera mitad del siglo XIX. Fray Gerundio (1837-1842)Ceballos Viro, Alvaro in Iberoamericana (2016), XVI(62), 238-239Detailed reference viewed: 10 (0 ULg) Expanding the clinical and mutational spectrum of the Ehlers-Danlos syndrome Dermatosparaxis.Van Damme, Tim; Colige, Alain ; Syx, Delfien et alin Genetics in Medicine : Official Journal of the American College of Medical Genetics (2016)Detailed reference viewed: 115 (4 ULg) ORCHIDEE-CROP (v0), a new process based Agro-Land Surface Model: model description and evaluation over EuropeWu, Xiuchen; Vuichard, N.; Ciais, P. et alin Geoscientific Model Development Discussions [=GMDD] (2016), 8Detailed reference viewed: 40 (5 ULg) compte rendu de : Lenglet-Dufresnoy, Écrits inédits sur le roman. Édité par J. Herman et J. Cormier. Oxford, Voltaire Foundation, 2014.Decoster, Sara in Revue d'Histoire Littéraire de la France (2016), 116(1), 222-224Detailed reference viewed: 23 (3 ULg) Bone disease after kidney transplantationBOUQUEGNEAU, Antoine ; Salam, Syrazah; DELANAYE, Pierre et alin Clinical Journal of the American Society of Nephrology (2016), 11(7), 1282-1296Detailed reference viewed: 28 (7 ULg) Long-term activity and outburst of comet C/2013 A1 (Siding Spring) from narrow-band photometry and long-slit spectroscopyOpitom, Cyrielle ; Guilbert-Lepoutre, A.; Jehin, Emmanuel et alin Astronomy and Astrophysics (2016), 589(A8), In this paper, we present a unique data set of more than one year's worth of regular observations of comet C/2013 A1(Siding Spring) with TRAPPIST in Chile, along with low-resolution spectra obtained with ... [more ▼]In this paper, we present a unique data set of more than one year's worth of regular observations of comet C/2013 A1(Siding Spring) with TRAPPIST in Chile, along with low-resolution spectra obtained with the ESO/VLT FORS 2 instrument. The comet made a close approach to Mars on October 19, 2014 and was then observed by many space and ground-based telescopes. We followed the evolution of the OH, NH, CN, $\mathrm{C_3}$, and $\mathrm{C_2}$ production rates as well as the $Af\rho$ parameter as a proxy for the dust production. We detected an outburst two weeks after perihelion, with gas and dust production rates being multiplied by a factor five within a few days. By modelling the shape of the CN and $\mathrm{C_2}$ radial profiles, we determined that the outburst happened around on November 10 around 15:30 UT ($\pm$ 5h) and measured a gas ejection velocity of $1.1\pm0.2$ km/s. We used a thermal evolution model to reproduce the activity pattern and outburst. Our results are consistent with the progressive formation of a dust mantle explaining the shallow dependence of gas production rates, which may be partially blown off during the outburst. We studied the evolution of gas composition, using various ratios such as CN/OH, $\mathrm{C_2}$/OH, or $\mathrm{C_3}$/OH, which showed little or no variation with heliocentric distance including at the time of the outburst. This indicates a relative level of homogeneity of the nucleus composition. [less ▲]Detailed reference viewed: 28 (7 ULg) Effects of fish predation on Posidonia oceanica amphipod assemblagesSturaro, Nicolas ; Gobert, Sylvie ; Pérez-Perera, Amanda et alin Marine Biology (2016), 163Amphipod assemblages that inhabit Posidonia oceanica seagrass meadows are potentially relevant trophic resources for ichthyofauna. However, the effects of fish predation on amphipod assemblages in this ... [more ▼]Amphipod assemblages that inhabit Posidonia oceanica seagrass meadows are potentially relevant trophic resources for ichthyofauna. However, the effects of fish predation on amphipod assemblages in this system have received little attention. To address this gap in knowledge, experimental manipulations of predation intensity (exclusion and inclusion cages) were conducted at two sites in a Mediterranean marine protected area, where different levels of fish predation were expected to occur. We found that in the absence of predatory fishes (exclusion cages), total amphipod density and biomass were higher than in uncaged areas and partially controlled cages. At the species level, Caprella acanthifera and Iphimedia minuta responded to caging with increased abundance, while in most cases different species did not exhibit differences in density or biomass between treatments. The presence of one enclosed labrid fish predator (inclusion cages) resulted in a lower density and biomass of Aora spinicornis and a lower biomass of Phtisica marina, although total amphipod density and biomass were unchanged. In the inclusion cages, a size-frequency analysis revealed that predators mainly targeted large A. spinicornis and Apherusa chiereghinii individuals. Our results suggest that predation by fish may be an important factor in controlling amphipod abundances and biomasses in P. oceanica meadows. Overall, amphipod community composition was not affected by exclusion or inclusion of fish predators. However, some significant effects at the species level point to more complex interactions between some amphipods and fish. [less ▲]Detailed reference viewed: 42 (6 ULg) Phosphorus and nitrogen derivatization as efficient route for improvement of lignin flame retardant action in PLACostes, Lucie; Laoutid, Fouad; Aguedo, Mario et alin European Polymer Journal (2016), 84The present study focuses on the use of lignin, which is the second most abundant constituent of the biomass, as sustainable flame retardant additive for polylactide (PLA). Indeed, thanks to its aromatic ... [more ▼]The present study focuses on the use of lignin, which is the second most abundant constituent of the biomass, as sustainable flame retardant additive for polylactide (PLA). Indeed, thanks to its aromatic structure, lignin could be advantageously used, in polymeric matrices, as a char promotor agent that can allow some reduction of the combustion rate. An original and simple approach, based on a two-step phosphorus/nitrogen chemical modification, is proposed to enhance the flame retardant effect of lignin in PLA. This approach has been applied on two different lignins, i.e. kraft and organosolv lignins. The effect of the plant origin, extraction mode of lignin as well as it chemical modification on both its structure and properties was investigated by using several characterization techniques. Fire properties and thermal behavior of PLA composites containing 20 wt% of both untreated and treated lignins were characterized by using cone calorimeter, UL-94 and thermogravimetric analysis (TGA). Results showed that the incorporation of untreated lignins led to a flame retardant action in PLA thanks to the formation of char but also to a significant loss of the thermal stability of PLA and to an important decrease of its time to ignition. In contrast, both phosphorus/nitrogen chemically treated lignins were found to limit PLA thermal degradation during melt processing as well as during TG experiments and also to significantly improve fire retardant properties allowing to reach V0 classification at UL-94. In this paper we also deeply investigated the nature of the gases evolved during thermal decomposition of treated and untreated lignins by using TGA-Mass spectrometer and cone calorimeter – FTIR couplings [less ▲]Detailed reference viewed: 15 (3 ULg) Etude de la séquence stratigraphique des loess de la carrière de Romont (Eben-Emael, Belgique) par une campagne géotechniqueDelvoie, Simon ; Pirson, Stéphane ; Charlier, Robert et alin Notae Praehistoricae (2016), 36The Romont quarry is recently considered as a new type section for the Middle Belgium loess deposits. The site displays a nearly 10 m thick loess sequence mainly dating from the Upper Pleistocene. The ... [more ▼]The Romont quarry is recently considered as a new type section for the Middle Belgium loess deposits. The site displays a nearly 10 m thick loess sequence mainly dating from the Upper Pleistocene. The Rocourt Pedocomplex, the Humiferous Complex of Remicourt, the Malplaquet Soil and the Nagelbeek Tongued Horizon are especially well developed. Classical approaches to study the loess sequence need observable sections. Unfortunately these sections are rare in Middle Belgium, often temporary and not deep enough. To identify reference horizons, archaeologists and geologists use to resort to hand auger sampling techniques. Investigation of loess by cone penetration tests could offer an alternative to the lack of outcrops and could be used complementary to hand drilling techniques. This study focuses on a methodology to approach as a first step the loess sequence to identify the presence or not of some layers and their extension. The investigation campaign performed on the site of Romont aims to define reference horizons based on mechanical properties by comparison with an observable outcrop. Then 16 cone penetration tests have been realized behind the working face. The campaign results reveal the existence of some horizons into the loess sequence. The transition between the Humiferous Complex of Remicourt and the Rocourt Pedocomplex is the most noticeable horizon. These two pedostratigraphic units are important due to the presence of archaeological materials in Middle Belgium and borderlands. Closer to the surface the Nagelbeek Tongued Horizon and the decarbonation limit are also highlighted from results of the geotechnical campaign. [less ▲]Detailed reference viewed: 52 (14 ULg) Neural correlates of successful memory retrieval in aging: Do executive functioning and task difficulty matter?Angel, Lucie; Bastin, Christine ; Genon, Sarah et alin Brain Research (2016), 1631Detailed reference viewed: 37 (4 ULg) Decline of the Black Sea oxygen inventoryCapet, Arthur; Stanev, Emil; Beckers, Jean-Marie et alin Biogeosciences (2016), 13Detailed reference viewed: 36 (7 ULg) Farmers’ Perception and Willingness to Pay for Climate Information in Burkina FasoZongo, Bétéo ; Diarra, Abdoulaye; Barbier, Bruno et alin Journal of Agricultural Science (2016), 8This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access ... [more ▼]This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access to climate information, while 93% of them need climate information to guide through their decision in planning agricultural activities. Option value shows the interest granted by farmers using climate information. About 64% of the farmers are willing to pay an average of Francs CFA 546.34 to obtain climate information. The willingness to pay is determined by the the farmers’ ability to predict the climate, to use radio as a means of information, farmers’ awareness of previous forecasts and early onset of rainy season. While farmers considered benefits from the use of climate information, it is clear that its contribution to farm income remains a field of research to explore. Thus it is necessary to experiment with individual farms and to evaluate the contribution of climate information to the value added in different crops and farmers’ income. [less ▲]Detailed reference viewed: 40 (5 ULg) Reference Method and Reference Material Are Necessary Tools to Reveal the Variability of Cystatin C AssaysBargnoux, Anne-Sophie; Kuster, Nils; Delatour, Vincent et alin Archives of Pathology & Laboratory Medicine (2016), 140(2), 117-118Detailed reference viewed: 45 (4 ULg) Covariance-constrained difference inversion of time-lapse electrical resistivity tomography dataHermans, Thomas ; Kemna, Andreas; Nguyen, Frédéric in Geophysics (2016), 81(5), 311-322Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active ... [more ▼]Hydrogeophysics has become a major field of research in the past two decades and time-lapse electrical resistivity tomography (ERT) is one of the most popular techniques to monitor passive and active processes in shallow subsurface reservoirs. Time-lapse inversion schemes have been developed to refine inversion results, but they mostly still rely on a spatial regularization procedure based on the standard smoothness constraint. In this paper, we propose to apply a covariance-based regularization operator in the time-lapse ERT inverse problem. We first illustrate the method for surface and cross-hole ERT with two synthetic cases and compare the results with the smoothness-constrained inversion (SCI). The examples show that the covariance–constrained inversions (CCI) better image the anomaly both in terms of shape and amplitude. Although more important in low-sensitivity zones, improvements are observed everywhere in the tomograms. Those synthetic examples also show that an error made in the range or in the type of the variogram model has a limited impact on the resulting image, which still remains better than SCI. The method is then applied to cross-borehole ERT field data from a heat tracing experiment, where the comparison with direct measurements shows a strong improvement of the breakthrough curves retrieved from ERT. The proposed method could be extended to the time dimension which would allow the use of CCI in 4D inversion schemes. [less ▲]Detailed reference viewed: 70 (18 ULg) Endocrine and social regulation of adult neurogenesis in songbirds.Balthazart, Jacques ; Ball, Gregory F.in Frontiers in neuroendocrinology (2016)The identification of pronounced seasonal changes in the volume of avian song control nuclei stimulated the discovery of adult neurogenesis in songbirds as well as renewed studies in mammals including ... [more ▼]The identification of pronounced seasonal changes in the volume of avian song control nuclei stimulated the discovery of adult neurogenesis in songbirds as well as renewed studies in mammals including humans. Neurogenesis in songbirds is modulated by testosterone and other factors such as photoperiod, singing activity and social environment. Adult neurogenesis has been widely studied by labeling, with tritiated thymidine or its analog BrdU, cells duplicating their DNA in anticipation of their last mitotic division and following their fate as new neurons. New methods based on endogenous markers of cell cycling or of various stages of neuronal life have allowed for additional progress. In particular immunocytochemical visualization of the microtubule-associated protein doublecortin has provided an integrated view of neuronal replacement in the song control nucleus HVC. Multiple questions remain however concerning the specific steps in the neuronal life cycle that are modulated by various factors and the underlying cellular mechanisms. [less ▲]Detailed reference viewed: 36 (5 ULg) Geographic range in liverworts: does sex really matter?Laenen, B.; Machac, A.; Gradstein, S.R. et alin Journal of Biogeography (2016)Detailed reference viewed: 44 (10 ULg) Decrease in climatic conditions favouring floods in the south-east of Belgium over 1959-2010 using the regional climate model MARWyard, Coraline ; Scholzen, Chloé ; Fettweis, Xavier et alin International Journal of Climatology (2016)The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and ... [more ▼]The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and about 50% of them are due to heavy rainfall events combined to an abrupt melting of the snowpack covering the Ardennes massif during winter. This study aims to determine whether trends in extreme hydroclimatic events generating floods can be detected over the last century in Belgium, where a global warming signal can be observed. Hydroclimatic conditions favourable to floods were reconstructed over 1959- 2010 using the regional climate model MAR (“Modèle Atmosphérique Régional”) forced by the ERA-Interim/ERA-40, the ERA-20C and the NCEP/NCAR-v1 reanalyses. Extreme run-off events, which could potentially generate floods, were detected using run-off caused by precipitation events and snowpack melting from the MAR model. In the validation process, the MAR-driven temperature, precipitation and snow depth were successfully compared to daily weather data over the period 2008-2014 for 20 stations in Belgium. MAR also showed its ability to detect up to 90% of the hydroclimatic conditions which effectively generated observed floods in the Ourthe River over the period 1974- 2010. Conditions favourable to floods in the Ourthe River catchment present a negative trend over the period 1959-2010 as a result of a decrease in snow accumulation and a shortening of the snow season. This trend is expected to accelerate in a warmer climate. However, regarding the impact of the extreme precipitation events evolution on conditions favouring floods, the signal is less clear since the trends depend on the reanalysis used to force the MAR model. [less ▲]Detailed reference viewed: 45 (16 ULg) Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myelomaBinsfeld, Marilène ; Muller, Joséphine ; Lamour, Virginie et alin Oncotarget (2016)Detailed reference viewed: 26 (2 ULg) Study of intact virus-like particles of human papillomavirus by capillary electrophoresisBettonville, Virginie ; Nicol, Jérôme ; Thelen, Nicolas et alin Electrophoresis (2016), 37Virus-like particles of human papillomavirus (HPV-VLP), resulting from the self-assembly of the capsid proteins (L1 or L1 and L2), have been widely used to study HPV as they are similar to the native ... [more ▼]Virus-like particles of human papillomavirus (HPV-VLP), resulting from the self-assembly of the capsid proteins (L1 or L1 and L2), have been widely used to study HPV as they are similar to the native virion. Moreover, two prophylactic vaccines, Gardasil® and Cervarix®, are based on HPV-VLP L1. Analytical techniques currently used to characterize HPV-VLP, such as SDS-PAGE, Western blot, ELISA, are time-consuming and semi-quantitative. In this study, capillary electrophoresis (CE) was evaluated for the analysis of intact HPV16-VLP. The usefulness of capillary inner wall coating as well as various BGEs, pH and detergent additives were investigated. Reproducible HPV-VLP analysis in CE was achieved using poly(ethylene oxide) coated capillary and a BGE containing high salt concentration and low SDS concentration. The developed method enables HPV-VLP detection in less than 10 min (migration times RSD : 1.6 %). The identity of HPV-VLP peak was confirmed by comparison with a sample obtained from a wild-type baculovirus and with VLP-based vaccine, Gardasil®, after adjuvant dissolution. Finally, we applied the developed methodology to VLP-based vaccines, demonstrating that CE could be successfully used for vaccine quality control. [less ▲]Detailed reference viewed: 73 (22 ULg) Genotyping and strain distribution of Mycobacterium avium subspecies hominissuis isolated from humans and pigs in Belgium, 2011-2013Vluggen, C; Soetaert, K; Duytschaever, L et alin Eurosurveillance (2016), 21(3), 18-25Detailed reference viewed: 12 (0 ULg) Saturn’s auroral morphology and field-aligned currents during a solar wind compressionBadman, S.V.; Provan, G.; Bunce, E.J. et alin Icarus (2016)Detailed reference viewed: 27 (6 ULg) Distribution under elliptical symmetry of a distance-based multivariate coefficient of variationAerts, Stéphanie ; Haesbroeck, Gentiane ; Ruwet, Christel in Statistical Papers (2016)Detailed reference viewed: 98 (38 ULg) Crystal structure of bassetite and saléeite: new insight into autunite-group mineralsDal Bo, Fabrice ; Hatert, Frédéric ; Mees, Florias et alin European Journal of Mineralogy (2016)Detailed reference viewed: 32 (11 ULg) Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells.Mendes, Luis Filipe; Tam, Wai Long; Chai, Yoke Chin et alin Tissue Engineering. Part C, Methods (2016), 22(5), 473-86Successful application of cell-based strategies in cartilage and bone tissue engineering has been hampered by the lack of robust protocols to efficiently differentiate mesenchymal stem cells into the ... [more ▼]Successful application of cell-based strategies in cartilage and bone tissue engineering has been hampered by the lack of robust protocols to efficiently differentiate mesenchymal stem cells into the chondrogenic lineage. The development of chemically defined culture media supplemented with growth factors (GFs) has been proposed as a way to overcome this limitation. In this work, we applied a fractional design of experiment (DoE) strategy to screen the effect of multiple GFs (BMP2, BMP6, GDF5, TGF-beta1, and FGF2) on chondrogenic differentiation of human periosteum-derived mesenchymal stem cells (hPDCs) in vitro. In a micromass culture (muMass) system, BMP2 had a positive effect on glycosaminoglycan deposition at day 7 (p < 0.001), which in combination with BMP6 synergistically enhanced cartilage-like tissue formation that displayed in vitro mineralization capacity at day 14 (p < 0.001). Gene expression of muMasses cultured for 7 days with a medium formulation supplemented with 100 ng/mL of BMP2 and BMP6 and a low concentration of GDF5, TGF-beta1, and FGF2 showed increased expression of Sox9 (1.7-fold) and the matrix molecules aggrecan (7-fold increase) and COL2A1 (40-fold increase) compared to nonstimulated control muMasses. The DoE analysis indicated that in GF combinations, BMP2 was the strongest effector for chondrogenic differentiation of hPDCs. When transplanted ectopically in nude mice, the in vitro-differentiated muMasses showed maintenance of the cartilaginous phenotype after 4 weeks in vivo. This study indicates the power of using the DoE approach for the creation of new medium formulations for skeletal tissue engineering approaches. [less ▲]Detailed reference viewed: 23 (0 ULg) Sex differences in partner preferences in humans and animals.Balthazart, Jacques in Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2016), 371(1688), A large number of morphological, physiological and behavioural traits are differentially expressed by males and females in all vertebrates including humans. These sex differences, sometimes, reflect the ... [more ▼]A large number of morphological, physiological and behavioural traits are differentially expressed by males and females in all vertebrates including humans. These sex differences, sometimes, reflect the different hormonal environment of the adults, but they often remain present after subjects of both sexes are placed in the same endocrine conditions following gonadectomy associated or not with hormonal replacement therapy. They are then the result of combined influences of organizational actions of sex steroids acting early during development, or genetic differences between the sexes, or epigenetic mechanisms differentially affecting males and females. Sexual partner preference is a sexually differentiated behavioural trait that is clearly controlled in animals by the same type of mechanisms. This is also probably true in humans, even if critical experiments that would be needed to obtain scientific proof of this assertion are often impossible for pragmatic or ethical reasons. Clinical, epidemiological and correlative studies provide, however, converging evidence strongly suggesting, if not demonstrating, that endocrine, genetic and epigenetic mechanisms acting during the pre- or perinatal life control human sexual orientation, i.e. homosexuality versus heterosexuality. Whether they interact with postnatal psychosexual influences remains, however, unclear at present. [less ▲]Detailed reference viewed: 50 (16 ULg) Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.Jurczyszyn, Artur; Grzasko, Norbert; Gozzetti, Alessandro et alin American journal of hematology (2016), 91(6), 575-80The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of ... [more ▼]The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate and multivariate analyses were performed to identify prognostic factors for survival. The median time from MM diagnosis to CNS MM diagnosis was 3 years. Thirty-eight patients (22%) were diagnosed with CNS involvement at the time of initial MM diagnosis and 134 (78%) at relapse/progression. Upon diagnosis of CNS MM, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated and treated patients had median OS of 2 and 8 months, respectively (P < 0.001). At least one previous line of therapy for MM before the diagnosis of CNS disease and >1 cytogenetic abnormality detected by FISH were independently associated with worse OS. The median OS for patients with 0, 1 and 2 of these risk factors were 25 months, 5.5 months and 2 months, respectively (P < 0.001). Neurological manifestations, not considered chemotherapy-related, observed at any time after initial diagnosis of MM should raise a suspicion of CNS involvement. Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy. Am. J. Hematol. 91:575-580, 2016. (c) 2016 Wiley Periodicals, Inc. [less ▲]Detailed reference viewed: 15 (1 ULg) Like a bridge over troubled water – opening pathways for integrating social sciences and humanities into nuclear researchTurcanu, Catrinel; Schröder, Jantine; Meskens, Gaston et alin Journal of Environmental Radioactivity (2016), 153Research on nuclear technologies has been largely driven by a detachment of the 'technical content' from the 'social context'. However, social studies of science and technology - also for the nuclear ... [more ▼]Research on nuclear technologies has been largely driven by a detachment of the 'technical content' from the 'social context'. However, social studies of science and technology - also for the nuclear domain – emphasize that 'the social' and 'the technical' dimensions of technology development are inter-related and co-produced. In an effort to create links between nuclear research and innovation and society in mutually beneficial ways, the Belgian Nuclear Research Centre started fifteen years ago a ‘Programme of Integration of Social Aspects into nuclear research’ (PISA). In line with broader science-policy agendas (responsible research and innovation and technology assessment), this paper argues that the importance of such programmes is threefold. First, their multi-disciplinary basis and participatory character contribute to a better understanding of the interactions between science, technology and society, in general, and the complexity of nuclear technology assessment in particular. Second, their functioning as (self )critical policy supportive research with outreach to society is an essential prerequisite for policies aiming at generating societal trust in the context of controversial issues related to nuclear technologies and exposure to ionising radiation. Third, such programmes create an enriching dynamic in the organisation itself, stimulating collective learning and transdisciplinarity. The paper illustrates with concrete examples these claims and concludes by discussing some key challenges that researchers face while engaging in work of this kind. [less ▲]Detailed reference viewed: 37 (0 ULg) Logistics Service Quality: The Case of Da Nang CityLimbourg, Sabine ; Giang, Ho Thi Quynh; Cools, Mario in Procedia Engineering (2016), 142Cost minimization is a key objective in managing logistics services. In this context, a growing interest in quality improvement can be observed. However, service quality is hard to quantify as it is a ... [more ▼]Cost minimization is a key objective in managing logistics services. In this context, a growing interest in quality improvement can be observed. However, service quality is hard to quantify as it is a function of varying customer perceptions over time, of the measurement process and of the analysis of the data gathered. This study examines the logistics service quality by scales developed according to SERVQUAL instrument. A survey of 200 customers of logistics service providers (LSP) was conducted in Da Nang City. The data analysis shows that LSPs in Da Nang city need to improve Research and Development and to develop Customer Care programs. [less ▲]Detailed reference viewed: 42 (8 ULg) Differential effects of context on psychomotor sensitization to ethanol and cocaineDidone, Vincent ; Quoilin, Caroline; Dieupart, Julie et alin Behavioural Pharmacology (2016), 27(2 & 3), 173-181Repeated drug injections lead to sensitization of their stimulant effects in mice, a phenomenon sometimes referred to as drug psychomotor sensitization. Previous studies showed that sensitization to ... [more ▼]Repeated drug injections lead to sensitization of their stimulant effects in mice, a phenomenon sometimes referred to as drug psychomotor sensitization. Previous studies showed that sensitization to cocaine is context dependent as its expression is reduced in an environment that was not paired with cocaine administration. In contrast, the effects of the test context on ethanol sensitization remain unclear. In the present study, female OF1 mice were repeatedly injected with 1.5 g/kg ethanol to test for both the effects of context novelty/familiarity and association on ethanol sensitization. A first group of mice was extensively pre-exposed to the test context before ethanol sensitization and ethanol injections were paired with the test context (familiar and paired group). A second group was not pre-exposed to the test context, but ethanol injections were paired with the test context (nonfamiliar and paired group). Finally, a third group of mice was not pre-exposed to the test context and ethanol was repeatedly injected in the home cage (unpaired group). Control groups were similarly exposed to the test context, but were injected with saline. In a second experiment, cocaine was used as a positive control. The same behavioral procedure was used, except that mice were injected with 10 mg/kg cocaine instead of ethanol. The results show a differential involvement of the test context in the sensitization to ethanol and cocaine. Cocaine sensitization is strongly context dependent and is not expressed in the unpaired group. In contrast, the expression of ethanol sensitization is independent of the context in which it was administered, but is strongly affected by the relative novelty/familiarity of the environment. Extensive pre-exposure to the test context prevented the expression of ethanol sensitization. One possible explanation is that expression of ethanol sensitization requires an arousing environment. [less ▲]Detailed reference viewed: 64 (19 ULg) Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergiiLafontaine, Anne ; Gismondi, Eric ; Boulangé-Lecomte, Céline et alin Aquatic Toxicology (2016)Detailed reference viewed: 33 (16 ULg) Reduction in cardiovascular and all-cause mortality in the EMPA-REG OUTCOME trial: A critical analysis.SCHEEN, André in Diabetes & metabolism (2016), 42(2), 71-6Detailed reference viewed: 30 (4 ULg) Combining feature extraction methods to assist the diagnosis of Alzheimer's diseaseSegovia, Fermin; Górriz, J. M.; Ramírez, J. et alin Current Alzheimer Research (2016), 13Neuroimaging data as 18F-FDG PET is widely used to assist the diagnosis of Alzheimer’s disease (AD). Looking for regions with hypoperfusion/ hypometabolism, clinicians may predict or corroborate the ... [more ▼]Neuroimaging data as 18F-FDG PET is widely used to assist the diagnosis of Alzheimer’s disease (AD). Looking for regions with hypoperfusion/ hypometabolism, clinicians may predict or corroborate the diagnosis of the patients. Modern computer aided diagnosis (CAD) systems based on the statistical analysis of whole neuroimages are more accurate than classical systems based on quantifying the uptake of some predefined regions of interests (ROIs). In addition, these new systems allow determining new ROIs and take advantage of the huge amount of information comprised in neuroimaging data. A major branch of modern CAD systems for AD is based on multivariate techniques, which analyse a neuroimage as a whole, considering not only the voxel intensities but also the relations among them. In order to deal with the vast dimensionality of the data, a number of feature extraction methods have been successfully applied. In this work, we propose a CAD system based on the combination of several feature extraction techniques. First, some commonly used feature extraction methods based on the analysis of the variance (as principal component analysis), on the factorization of the data (as non-negative matrix factorization) and on classical magnitudes (as Haralick features) were simultaneously applied to the original data. These feature sets were then combined by means of two different combination approaches: i) using a single classifier and a multiple kernel learning approach and ii) using an ensemble of classifier and selecting the final decision by majority voting. The proposed approach was evaluated using a labelled neuroimaging database along with a cross validation scheme. As conclusion, the proposed CAD system performed better than approaches using only one feature extraction technique. We also provide a fair comparison (using the same database). [less ▲]Detailed reference viewed: 114 (28 ULg) SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma.Edimo, William S Elong; Ghosh, Somadri; Derua, Rita et alin Journal of cell science (2016)Phosphoinositides, particularly PI(3,4,5)P3, and PI(4,5)P2, are recognized by SHIP2 a member of the inositol polyphosphate 5-phosphatase family. SHIP2 dephosphorylates PI(3,4,5)P3 to form PI(3,4)P2; the ... [more ▼]Phosphoinositides, particularly PI(3,4,5)P3, and PI(4,5)P2, are recognized by SHIP2 a member of the inositol polyphosphate 5-phosphatase family. SHIP2 dephosphorylates PI(3,4,5)P3 to form PI(3,4)P2; the latter interacts with specific target proteins (e.g. lamellipodin). Although the SHIP2 preferred substrate is PI(3,4,5)P3, PI(4,5)P2 could also be dephosphorylated to PI4P. Through depletion of SHIP2 in a glioblastoma cell line 1321 N1 cells, we show that SHIP2 inhibits cell migration. In different glioblastoma cell lines and primary cultures, SHIP2 staining at the plasma membrane partly overlaps with PI(4,5)P2 immunoreactivity. PI(4,5)P2 was upregulated in SHIP2-deficient N1 cells as compared to control cells; in contrast, PI4P was very much decreased in SHIP2-deficient cells. Therefore, SHIP2 controls both PI(3,4,5)P3 and PI(4,5)P2 levels in intact cells. In N1 cells, the PI(4,5)P2 binding protein myosin-1c was identified as a new interactor of SHIP2. Regulation of PI(4,5)P2 and PI4P content by SHIP2 controls N1 cell migration through the organization of focal adhesions. Thus, our results reveal a novel role of SHIP2 in the control of PI(4,5)P2, PI4P and cell migration in PTEN-deficient glioblastoma N1 cells. [less ▲]Detailed reference viewed: 17 (5 ULg) Life cycle assessment of hybrid vehicles recycling: Comparison of three business lines of dismantlingBelboom, Sandra ; Lewis, Grégory; Bareel, Pierre-François et alin Waste Management (2016), 50This paper undertakes an environmental evaluation of hybrid vehicles recycling, using industrial data from Comet Traitement SA in Belgium. Three business lines have been modelled and analysed. The first ... [more ▼]This paper undertakes an environmental evaluation of hybrid vehicles recycling, using industrial data from Comet Traitement SA in Belgium. Three business lines have been modelled and analysed. The first one is relative to the business as usual with a dismantling to recover batteries and engines followed by shredding and post shredding treatments. The second one considers, in addition, the removal of electronic control units (ECU) before shredding followed by same steps than in the first line and the last one is relative to the additional removal of big plastic parts before shredding and business as usual post shredding treatments. Results show non-significant environmental benefits when ECU or large parts of plastics are recovered before shredding. Improvements in terms of environmental benefits are lower than the uncertainty of the results. Indeed, the performing usual process for end-of-life vehicles (ELV) treatment reaches 97% of the ELV which is valorised in terms of metal and energy recoveries. Post shredding treatment units include metals, plastics and energy recovery of residues. Comet business as usual route for ELV valorisation is in accordance with the requirements of the European directive and recommendations for further improvement with dismantling of other parts (ECU or plastics) before shredding are non-relevant in this case. [less ▲]Detailed reference viewed: 37 (14 ULg) IgE and mast cells in host defense against parasites and venoms.Mukai, Kaori; Tsai, Mindy; Starkl, Philipp et alin Seminars in Immunopathology (2016)IgE-dependent mast cell activation is a major effector mechanism underlying the pathology associated with allergic disorders. The most dramatic of these IgE-associated disorders is the fatal anaphylaxis ... [more ▼]IgE-dependent mast cell activation is a major effector mechanism underlying the pathology associated with allergic disorders. The most dramatic of these IgE-associated disorders is the fatal anaphylaxis which can occur in some people who have developed IgE antibodies to otherwise innocuous antigens, such as those contained in certain foods and medicines. Why would such a highly "maladaptive" immune response develop in evolution and be retained to the present day? Host defense against parasites has long been considered the only beneficial function that might be conferred by IgE and mast cells. However, recent studies have provided evidence that, in addition to participating in host resistance to certain parasites, mast cells and IgE are critical components of innate (mast cells) and adaptive (mast cells and IgE) immune responses that can enhance host defense against the toxicity of certain arthropod and animal venoms, including enhancing the survival of mice injected with such venoms. Yet, in some people, developing IgE antibodies to insect or snake venoms puts them at risk for having a potentially fatal anaphylactic reaction upon subsequent exposure to such venoms. Delineating the mechanisms underlying beneficial versus detrimental innate and adaptive immune responses associated with mast cell activation and IgE is likely to enhance our ability to identify potential therapeutic targets in such settings, not only for reducing the pathology associated with allergic disorders but perhaps also for enhancing immune protection against pathogens and animal venoms. [less ▲]Detailed reference viewed: 6 (1 ULg) Modular Diversification of the Locomotor System in Damselfishes (Pomacentridae)Aguilar-Medrano, Rosalia; Frederich, Bruno ; Barber, Paul H.in Journal of Morphology (2016)As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have ... [more ▼]As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have inhabited coral reef ecosystems for more than 50 million years. As such, habitat preferences and behavior could significantly constrain the morphology and evolvability of the locomotor system. To test this hypothesis, we used phylogenetic comparative methods on morphometric, ecological and behavioral data. While body elongation represented the primary source of variation in the locomotor system of damselfishes, results also showed a diverse suite of morphological combinations between extreme morphologies. Results show clear associations between behavior, habitat preferences, and morphology, suggesting ecological constraints on shape diversification of the locomotor system. In addition, results indicate that the three modules of the locomotor system are weakly correlated, resulting in versatile and independent characters. These results suggest that Pomacentridae is shape may result from the interaction between (1) integrated parts of morphological variation that main- tain overall swimming ability and (2) relatively independent parts of the morphology that facilitate adaptation and diversification. [less ▲]Detailed reference viewed: 14 (4 ULg) Subunit Asa1 spans all the peripheral stalk of the mitochondrial ATP synthase of the chlorophycean alga Polytomella sp.Colina-Tenorio, Lilia; Miranda-Astudillo, Hector; Cano-Estrada, Araceli et alin Biochimica et biophysica acta (2016)Mitochondrial F1FO-ATP synthase of chlorophycean algae is dimeric. It contains eight orthodox subunits (alpha, beta, gamma, delta, epsilon, OSCP, a and c) and nine atypical subunits (Asa1 to 9). These ... [more ▼]Mitochondrial F1FO-ATP synthase of chlorophycean algae is dimeric. It contains eight orthodox subunits (alpha, beta, gamma, delta, epsilon, OSCP, a and c) and nine atypical subunits (Asa1 to 9). These subunits build the peripheral stalk of the enzyme and stabilize its dimeric structure. The location of the 66.1kDa subunit Asa1 has been debated. On one hand, it was found in a transient subcomplex that contained membrane-bound subunits Asa1/Asa3/Asa5/Asa8/a (Atp6)/c (Atp9). On the other hand, Asa1 was proposed to form the bulky structure of the peripheral stalk that contacts the OSCP subunit in the F1 sector. Here, we overexpressed and purified the recombinant proteins Asa1 and OSCP and explored their interactions in vitro, using immunochemical techniques and affinity chromatography. Asa1 and OSCP interact strongly, and the carboxy-terminal half of OSCP seems to be instrumental for this association. In addition, the algal ATP synthase was partially dissociated at relatively high detergent concentrations, and an Asa1/Asa3/Asa5/Asa8/a/c10 subcomplex was identified. Furthermore, Far-Western analysis suggests an Asa1-Asa8 interaction. Based on these results, a model is proposed in which Asa1 spans the whole peripheral arm of the enzyme, from a region close to the matrix-exposed side of the mitochondrial inner membrane to the F1 region where OSCP is located. 3D models show elongated, helix-rich structures for chlorophycean Asa1 subunits. Asa1 subunit probably plays a scaffolding role in the peripheral stalk analogous to the one of subunit b in orthodox mitochondrial enzymes. [less ▲]Detailed reference viewed: 68 (5 ULg) Real-Time Optimization of Organic Rankine Cycle Systems by Extremum-Seeking ControlHernandez Naranjo, Jairo Andres ; Desideri, Adriano ; Ionescu, Clara et alin Energies (2016), 9In this paper, the optimal operation of a stationary sub-critical 11kWel organic Rankine cycle (ORC) unit for waste heat recovery (WHR) applications is investigated, both in terms of energy production and ... [more ▼]In this paper, the optimal operation of a stationary sub-critical 11kWel organic Rankine cycle (ORC) unit for waste heat recovery (WHR) applications is investigated, both in terms of energy production and safety conditions. Simulation results of a validated dynamic model of the ORC power unit are used to derive a correlation for the evaporating temperature, which maximizes the power generation for a range of operating conditions. This idea is further extended using a perturbation-based extremum seeking (ES) algorithm to identify online the optimal evaporating temperature. Regarding safety conditions, we propose the use of the extended prediction self-adaptive control (EPSAC) approach to constrained model predictive control (MPC). Since it uses input/output models for prediction, it avoids the need for state estimators, making it a suitable tool for industrial applications. The performance of the proposed control strategy is compared to PID-like schemes. Results show that EPSAC-MPC is a more effective control strategy, as it allows a safer and more efficient operation of the ORC unit, as it can handle constraints in a natural way, operating close to the boundary conditions where power generation is maximized. [less ▲]Detailed reference viewed: 29 (4 ULg) Large-scale signatures of unconsciousness are consistent with a departure from critical dynamicsTagliazucchi, E.; Chialvo, D. R.; Siniatchkin, M. et alin Journal of the Royal Society Interface (2016), 13(114), Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. In this study, we arrive at a basic ... [more ▼]Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. In this study, we arrive at a basic model explaining these observations based on the theory of phase transitions in complex systems. We studied the link between spatial and temporal correlations of large-scale brain activity recorded with functional magnetic resonance imaging during wakefulness, propofol-induced sedation and loss of consciousness and during the subsequent recovery. We observed that during unconsciousness activity in frontothalamic regions exhibited a reduction of long-range temporal correlations and a departure of functional connectivity from anatomical constraints. A model of a system exhibiting a phase transition reproduced our findings, as well as the diminished sensitivity of the cortex to external perturbations during unconsciousness. This framework unifies different observations about brain activity during unconsciousness and predicts that the principles we identified are universal and independent from its causes. © 2016 The Author(s) Published by the Royal Society. All rights reserved. [less ▲]Detailed reference viewed: 15 (1 ULg) Hallucinations, loneliness, and social isolation in Alzheimer’s diseaseEl Haj, M; Jardri, R; Laroi, Frank et alin Cognitive Neuropsychiatry (2016), 6Detailed reference viewed: 17 (1 ULg) Kisspeptin Expression in the Human Infundibular Nucleus in Relation to Sex, Gender Identity, and Sexual Orientation.Taziaux, Mélanie ; Staphorsius, Annemieke S.; Ghatei, Mohammad A. et alin Journal of Clinical Endocrinology and Metabolism (2016), 101(6), 2380-9CONTEXT: Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex ... [more ▼]CONTEXT: Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex differences in kisspeptin expression have been shown in humans in adulthood, the developmental origin of this sex difference is unknown. OBJECTIVES: Our objectives were to determine the following: 1) when during development the sex difference in kisspeptin expression in the infundibular nucleus would emerge and 2) whether this sex difference is related to sexual orientation or transsexuality. DESIGN AND SETTING: Postmortem hypothalamic tissues were collected by The Netherlands Brain Bank, and sections were stained for kisspeptin by immunohistochemistry. PATIENTS: Hypothalami of 43 control subjects were categorized into three periods: infant/prepubertal (six girls, seven boys), adult (11 women, seven men), and elderly (six aged women, six aged men). Eight male-to-female (MTF) transsexuals, three HIV(+) heterosexual men, and five HIV(+) homosexual men were also analyzed. MAIN OUTCOME MEASURE: We estimated the total number of kisspeptin-immunoreactive neurons within the infundibular nucleus. RESULTS: Quantitative analysis confirmed that the human infundibular kisspeptin system exhibits a female-dominant sex difference. The number of kisspeptin neurons is significantly greater in the infant/prepubertal and elderly periods compared with the adult period. Finally, in MTF transsexuals, but not homosexual men, a female-typical kisspeptin expression was observed. CONCLUSIONS: These findings suggest that infundibular kisspeptin neurons are sensitive to circulating sex steroid hormones throughout life and that the sex reversal observed in MTF transsexuals might reflect, at least partially, an atypical brain sexual differentiation. [less ▲]Detailed reference viewed: 19 (3 ULg) Soft power, global governance of cultural industries and rising powers: the case of ChinaVlassis, Antonios in International Journal of Cultural Policy (2016), 22(4)This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to ... [more ▼]This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to shape the structures of their international environment. More specifically, studying the cases of People’s Republic of China and of the movie industry, my article focuses on the current evolution of the relationship between the Chinese authorities and the film industry, as well as on the development of the domestic film market. I further aim to draw up an inventory of China’s role within the global governance of cultural industries. Finally, I aim to highlight the global cultural competition that China faces, emphasizing the practices of the US administration and Hollywood. I argue that even if China is the current centre of gravity within the world economy, it still has a long way to go in order to shape the distribution of resources within the global governance of cultural industries and to play a crucial role in the international battle of cultural symbols. [less ▲]Detailed reference viewed: 124 (16 ULg) Sound Production by a Recoiling System in the Pempheridae and TerapontidaeParmentier, Eric ; Fine, Michael; Mok, Hin-Kiuin Journal of Morphology (2016)Sound-producing mechanisms in fishes are extraordinarily diversified. We report here original mechanisms of three species from two families: the pempherid Pempheris oualensis, and the terapontids Terapon ... [more ▼]Sound-producing mechanisms in fishes are extraordinarily diversified. We report here original mechanisms of three species from two families: the pempherid Pempheris oualensis, and the terapontids Terapon jarbua and Pelates quadrilineatus. All sonic mechanisms are built on the same structures. The rostral part of the swimbladder is connected to a pair of large sonic muscles from the head whereas the posterior part is fused with bony widenings of vertebral bodies. Two bladder regions are separated by a stretchable fenestra that allows forward extension of the anterior bladder during muscle contraction. A recoiling apparatus runs between the inner face of the anterior swimbladder and a vertebral body expansion. The elastic nature of the recoiling apparatus supports its role in helping the swimbladder to recover its initial position during sonic muscle relaxation. This system should aid fast contraction (between 100 and 250Hz) of sonic muscles. There are many differences between species in terms of the swimbladder and its attachments to the vertebral column, muscle origins, and morphology of the recoiling apparatus. The recoiling apparatus found in the phylogenetically-related families (Glaucosomatidae, Pempheridae, Terapontidae) could indicate a new character within the Percomorpharia. [less ▲]Detailed reference viewed: 31 (4 ULg) Trace Elements in Marine Environments : Occurrence, Threats and Monitoring with Special Focus on the Costal MediterraneanRichir, Jonathan ; Gobert, Sylvie in Journal of Environmental and Analytical Toxicology (2016), 6:1Trace elements, as building blocks of matter, are naturally present in the environment. However, their extraction, production, use and release by men can lead to the increase of their environmental levels ... [more ▼]Trace elements, as building blocks of matter, are naturally present in the environment. However, their extraction, production, use and release by men can lead to the increase of their environmental levels to concentrations that may be toxic for both men and the biota. The overall aim of this review is therefore to recall that trace elements remain contaminants of concern that still require scientific attention. Because marine coastal systems (and transitional environments in general) are particularly vulnerable to contamination processes, they deserve to be accurately monitored with quality indicator species. As an example, the 2 most widely quality indicator species used to assess the health status of the coastal Mediterranean are the seagrass Posidonia oceanica and the mussel Mytilus galloprovincialis. In this review, after a short introduction on human pressures on the World Ocean and the coastal Mediterranean in particular (1), we will redefine the term trace element from an environmental perspective and discuss their accumulation and toxicity for men and the biota (2). We will consider the benefits of using biological indicators instead of water and sediment measurements to assess the health status of the marine environment (3), and more particularly as regards the accurate and complementary indicators that are seagrasses (4) and mussels (5). [less ▲]Detailed reference viewed: 57 (8 ULg) The spatiality of local governments in European intermediate urban regions: a methodological approachBreuer, Christophe ; Halleux, Jean-Marie in Quaestiones Geographicae (2016)Local authorities are central actors in the governance of European intermediate urban regions. In this paper, we propose a methodology to analyse the fragmentation of local authorities within 119 urban ... [more ▼]Local authorities are central actors in the governance of European intermediate urban regions. In this paper, we propose a methodology to analyse the fragmentation of local authorities within 119 urban regions. We tested several European databases to create indicators of fragmentation and to develop a typology of fragmentation within cities. Our results show that the Eurostat Cities programme gives a consistent spatial definition of urban regions and that their fragmentation is mainly influenced by national contexts. The developed methodology is a contribution to the debate on territorial reforms and urban governance transformations. [less ▲]Detailed reference viewed: 38 (12 ULg) On the distance travelled for woodland leisure via different transport modes in Wallonia, south BelgiumLi, Sen; Colson, Vincent; Lejeune, Philippe et alin Urban Forestry and Urban Greening (2016), 15Based on an extensive survey of woodland visitors in Wallonia, south Belgium, we examined a widerange of individual-, residential- and destination-level variables for their associations with the ... [more ▼]Based on an extensive survey of woodland visitors in Wallonia, south Belgium, we examined a widerange of individual-, residential- and destination-level variables for their associations with the distancetravelled for woodland leisure on foot, by bicycle and by car. For each transport mode, explanatorybivariate analyses were conducted firstly to identify potential correlates of the distances travelled. Then,cross-classified multilevel analysis was performed to build estimation models for the trip distance. Theresults showed that, amongst the multilevel variables selected, walking trip distance was only associatedwith individual trip behaviour, while cycling and car-borne trip distance could also be associated withindividual socio-economic profile as well as a large range of residential and destination attributes onland use, land cover and visitor support services. The final estimation model for (i) walking trip distanceincluded trip duration as the only explanatory variable, for (ii) cycling trip distance included variables ontrip duration, proportion of woodland area at residence and presence of service facilities at destination,and for (iii) car-borne trip distance included variables on trip duration, visitor’s employment status,whether the trip is on weekend or in summer, proportion of woodland area at residence and remotenessof destination from urban area. Despite being simple in form, all multilevel estimation models showa satisfactory explanatory power and a better performance than the ordinary single-level models. Ourresults add new empirical evidences on the key factors associated with the transport mode-specific traveldistance, in particular, for woodland leisure. The cross-classified multilevel analysis used in our studyprovides new methodological insights for the estimation of individual trip distance, which could benefitfuture modelling of woodland recreation demand. [less ▲]Detailed reference viewed: 12 (3 ULg) The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.Rambout, Xavier ; Detiffe, Cecile; Bruyr, Jonathan et alin Nature Structural & Molecular Biology (2016)Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical ... [more ▼]Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical transcription factors whose previously described functions are confined to the control of mRNA synthesis. Here, we report that ERG also regulates gene expression by affecting mRNA stability and identify the molecular mechanisms underlying this function in human cells. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. Transcriptome-wide mRNA stability analysis revealed that ERG controls the degradation of a subset of mRNAs highly connected to Aurora signaling, whose decay during S phase is necessary for mitotic progression. Our data indicate that control of gene expression by mammalian transcription factors may follow a more complex scheme than previously anticipated, integrating mRNA synthesis and degradation. [less ▲]Detailed reference viewed: 48 (13 ULg) An Improved Molecular Histology Method for Ion Suppression Monitoring and Quantification of Phosphatidyl Cholines During MALDI MSI Lipidomics Analyses.Jadoul, Laure ; Smargiasso, Nicolas ; Pamelard, Fabien et alin OMICS : A Journal of Integrative Biology (2016), 20(2), 110-21Tissue lipidomics is one of the latest omics approaches for biomarker discovery in pharmacology, pathology, and the life sciences at large. In this context, matrix-assisted laser desorption/ionization ... [more ▼]Tissue lipidomics is one of the latest omics approaches for biomarker discovery in pharmacology, pathology, and the life sciences at large. In this context, matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is the most versatile tool to map compounds within tissue sections. However, ion suppression events occurring during MALDI MSI analyses make it impossible to use this method for quantitative investigations without additional validation steps. This is especially true for lipidomics, since different lipid classes are responsible for important ion suppression events. We propose here an improved lipidomics method to assess local ion suppression of phospatidylcholines in tissues. Serial tissue sections were spiked with different amounts of PC(16:0 d31/18:1) using a nebulization device. Settings for standard nebulization were strictly controlled for a detection similar to when using spiked tissue homogenates. The sections were simultaneously analyzed by MALDI MSI using a Fourier transform ion cyclotron resonance analyzer. Such a spray-based approach allows taking into account the biochemical heterogeneity of the tissue for the detection of PC(16:0 d31/18:1). Thus, here we present the perspective to use this method for quantification purposes. The linear regression lines are considered as calibration curves and we calculate PC(16:0/18:1) quantification values for different ROIs. Although those values need to be validated by a using a different independent approach, the workflow offers an insight into new quantitative mass spectrometry imaging (q-MSI) methods. This approach of ion suppression monitoring of phosphocholines in tissues may be highly interesting for a large range of applications in MALDI MSI, particularly for pathology using translational science workflows. [less ▲]Detailed reference viewed: 102 (9 ULg) Convective drying behavior of sawdust-sludge mixtures in a fixed bedLi, Jie; Fraikin, Laurent ; Salmon, Thierry et alin Drying Technology (2016), 34(4), 395-402Detailed reference viewed: 32 (9 ULg) Time’s Up! Involvement of Metamemory Knowledge, Executive Functions, and Time Monitoring in Children’s Prospective Memory PerformanceGeurten, Marie ; Lejeune, Caroline ; Meulemans, Thierry in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016), 22(4), 443-457This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring ... [more ▼]This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring strategy depending on the ongoing task’s difficulty. Specifically, a sample of 72 typically developing children aged 4, 6, and 9 years old were given an original PM paradigm composed of both an ongoing procedural activity and a PM task. Half of the participants (expert group) were trained in the ongoing activity before the prospective test. As expected, results show that time monitoring had a positive effect on children’s PM performance. Furthermore, mediation analyses reveal that strategic time monitoring was predicted by metamemory knowledge in the expert group but only by executive functions in the novice group. Overall, these findings provide interesting avenues to explain how metamemory knowledge, strategy use, and executive functions interact to improve PM performance during childhood. [less ▲]Detailed reference viewed: 52 (10 ULg) Involvement of Executive Functions in Children’s MetamemoryGeurten, Marie ; Catale, Corinne ; Meulemans, Thierry in Applied Cognitive Psychology (2016), 30(1), 70-80This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were ... [more ▼]This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were assessed based on the performance of a group of 100 children (aged 4, 6, 9 and 11 years) on a battery of executive tasks. At the same time, the influence of variables such as intelligence, vocabulary and parental education level was also investigated. Results of mediation analyses reveal that the relation between children’s age and internal strategy knowledge was partially mediated by working memory skills but that executive functions did not mediate the impact of chronological age on children’s knowledge of external strategies or of memory functioning. Additionally, verbal fluency predicted internal and external strategy knowledge. Implications for general learning theories in childhood are discussed [less ▲]Detailed reference viewed: 31 (12 ULg) Compte-rendu de l'ouvrage de AA.VV.: L’Archi-politique de Gérard GranelZincq, Aurélien in Philosophie (2016)Detailed reference viewed: 19 (0 ULg) Critical analysis of the paramagnetic to ferromagnetic phase transition in Pr0.55K0.05Sr0.4MnO3Thaljaoui, R.; Pękała, M.; Fagnard, Jean-François et alin Physica B: Condensed Matter (2016), 482The critical properties of monovalent doped manganite Pr0.55K0.05Sr0.4MnO3 around the paramagnetic to ferromagnetic phase transition were investigated through various methods: the modified Arrott plots ... [more ▼]The critical properties of monovalent doped manganite Pr0.55K0.05Sr0.4MnO3 around the paramagnetic to ferromagnetic phase transition were investigated through various methods: the modified Arrott plots (MAP), the Kouvel-Fisher method and the critical isotherm analysis. Data obtained near Tc were examined in the framework of the mean field theory, the 3D–Heisenberg model, the 3D–Ising model, and tricritical mean field. The deduced critical exponents values obtained using MAP method were found to be β = 0.44(4) with TC ~ 303 K and γ = 1.04(1) with TC ~ 302 K. Kouvel-Fisher method supplies the critical values to be β = 0.41(2) with TC ~ 302 K and γ = 1.09(1) with TC ~ 302 K. The obtained critical parameters show a tendency towards the mean-field behavior, suggesting the existence of long-range ferromagnetic order in the compound studied. The exponent δ deduced separately from isotherm analysis at T= 303 K was found to obey to the Widom scaling relation δ = 1+ γ/ β. The reliability of obtained exponents was confirmed by using the universal scaling hypothesis. The itinerant character of ferromagnetism in the present system was also tested by using Rhodes-Wohlfarth’s criterion. [less ▲]Detailed reference viewed: 36 (9 ULg) Assessment of methods of detection of water estrogenicity for their use as monitoring tools in a process of estrogenicity removalBlavier; Songulashvili; Simon, Coraline et alin Environmental Technology (2016)Detailed reference viewed: 18 (5 ULg) FDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy.LOVINFOSSE, Pierre ; Janvary, Zsolt Levente; COUCKE, Philippe et alin European journal of nuclear medicine and molecular imaging (2016)INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume ... [more ▼]INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume or heterogeneity could predict the outcome in patients with non-small cell lung cancers (NSCLC) treated by stereotactic body radiation therapy (SBRT). METHODS: Sixty-three patients with NSCLC treated by SBRT underwent a 18F-FDG PET/CT before treatment. Maximum and mean standard uptake value (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), as well as 13 global, local and regional textural features were analysed. The predictive value of these parameters, along with clinical features, was assessed using univariate and multivariate analysis for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Cutoff values were obtained using logistic regression analysis, and survivals were compared using Kaplan-Meier analysis. RESULTS: The median follow-up period was 27.1 months for the entire cohort and 32.1 months for the surviving patients. At the end of the study, 25 patients had local and/or distant recurrence including 12 who died because of the cancer progression. None of the clinical variables was predictive of the outcome, except age, which was associated with DFS (HR 1.1, P = 0.002). None of the 18F-FDG PET/CT or clinical parameters, except gender, were associated with OS. The univariate analysis showed that only dissimilarity (D) was associated with DSS (HR = 0.822, P = 0.037), and that several metabolic measurements were associated with DFS. In multivariate analysis, only dissimilarity was significantly associated with DSS (HR = 0.822, P = 0.037) and with DFS (HR = 0.834, P < 0.01). CONCLUSION: The textural feature dissimilarity measured on the baseline 18F-FDG PET/CT appears to be a strong independent predictor of the outcome in patients with NSCLC treated by SBRT. This may help selecting patients who may benefit from closer monitoring and therapeutic optimization. [less ▲]Detailed reference viewed: 77 (13 ULg) Efficient standard error formulas of ability estimators with dichotomous item response modelsMagis, David in Psychometrika (2016), 81This paper focuses on the computation of asymptotic standard errors (ASE) of ability estimators with dichotomous item response models. A general framework is considered and ability estimators are defined ... [more ▼]This paper focuses on the computation of asymptotic standard errors (ASE) of ability estimators with dichotomous item response models. A general framework is considered and ability estimators are defined from a very restricted set of assumptions and formulas. This approach encompasses most standard methods such as maximum likelihood, weighted likelihood, maximum a posteriori and robust estimators. A general formula for the ASE is derived from the theory of M-estimation. Well-known results are found back as particular cases for the maximum and robust estimators, while new ASE proposals for the weighted likelihood and maximum a posteriori estimators are presented. These new formulas are compared to traditional ones by means of a simulation study under Rasch modeling. [less ▲]Detailed reference viewed: 21 (6 ULg) N-Acetylcysteine: An Old Drug With Variable Anti-Influenza PropertiesCasanova, Tomas; Garigliany, Mutien-Marie in Journal of Controversies in Biomedical Research (2016)Detailed reference viewed: 28 (1 ULg)