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See detailDirect intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats.
Gandini, M.; Cerri, Simona ULg; Pregel, P. et al

in Acta Cirurgica Brasileira (2016), 31(5), 333-337

ABSTRACT PURPOSE: To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on intestinal ischemic and reperfusion injury METHODS: Superior ... [more ▼]

ABSTRACT PURPOSE: To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on intestinal ischemic and reperfusion injury METHODS: Superior mesenteric artery was isolated and clamped in 36 adult male Sprague Dawley rats. After 60 minutes, clamp was removed and a group received intraperitoneally UNITO solution (PTX 25mg/kg + lidocaine 5mg/kg + MB 2mg/kg), while the other group was treated with warm 0.9% NaCl solution. Rats were euthanized 45 min after drug administration. Lung and bowel were collected for histological evaluation (using Park’s score) and determination of myeloperoxidase (MPO) and malondialdehyde (MDA) levels. RESULTS: Control samples showed lymphoplasmocytic infiltrate and crypt necrosis of villi. MPO and MDA measurements shown no differences between treated and control groups. CONCLUSION: The combination of lidocaine, methylene blue and pentoxyphylline administered intraperitoneally at the studied dose, did not decreased histological lesion scores and biochemical markers levels in intestinal ischemia/reperfusion injury. [less ▲]

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See detailModeling of granular solids with computational homogenization: Comparison with Biot's theory
Marinelli, F.; Van den Eijnden, AP; Sieffert, Y. et al

in Finite Elements in Analysis and Design (2016), 119

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See detailScénarios pour la Politique européenne de sécurité et de défense (PSDC)
Dumoulin, André ULg

in Sécurité & stratégie (2016), 122/2

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See detailRaisonnement analogique, connaissance relationnelle et troubles du langage.
Krzemien, Magali ULg

in Glossa (2016), 119

The construction grammar theory claims that language development is achieved thanks to the abstraction of schemas from different heard forms. This abstraction is allowed by analogical reasoning abilities ... [more ▼]

The construction grammar theory claims that language development is achieved thanks to the abstraction of schemas from different heard forms. This abstraction is allowed by analogical reasoning abilities. Analogical reasoning is a human ability, which allows to acquire new knowledge from known situations. Several theories tried to explain its development. Some of them claim that it is an ability that appears late in the development, while others support the hypothesis that it can be used early in the development under certain conditions. Some authors underline the influence of working memory, inhibition or relational knowledge. Relational knowledge about a specific domain will indeed allow to reason analogically and to move from a perceptual reasoning to a relational reasoning. Analogical reasoning and relational knowledge are both connected to language development, as these abilities influence each other. Because of this link, several authors investigated the analogical reasoning abilities of children with language disorders, and specifically of children with Specific Language Impairment (SLI). Those children seem to have poorer analogical reasoning abilities than their age-matched peers. This has implication for the use of analogies in the classroom context, but also for the language development of those children. [less ▲]

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See detaill'intelligence stratégique et territoriale : outils de développement et de souveraineté
Leroy, Patrick ULg

in Péventique (2016), 146

Face aux menaces de perte de souveraineté et d’appauvrissement, l’intelligence stratégique et territoriale doivent guider la politique d’attractivité et de développement souverain des territoires. L ... [more ▼]

Face aux menaces de perte de souveraineté et d’appauvrissement, l’intelligence stratégique et territoriale doivent guider la politique d’attractivité et de développement souverain des territoires. L'expérience belge, wallonne en particulier, pour le développement de cette intelligence stratégique est utile. [less ▲]

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See detailDeveloping Tourism Products and new Partnerships through Participative Action Research in Rural Cameroon
Schmitz, Serge ULg; Lekane Tsoubgou, Dieudonné

in Geographical Research (2016), 54(2), 143-152

The paper explores possible synergies between microfinance institutions and small and medium medium tourism businesses in the West Cameron Chiefdooms. Based on a research action the authors emphasise the ... [more ▼]

The paper explores possible synergies between microfinance institutions and small and medium medium tourism businesses in the West Cameron Chiefdooms. Based on a research action the authors emphasise the obstacles to the formation of partnership and describe how the researchers facilitated networking. [less ▲]

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See detailLes paysans sans terre et REDD+ en RDC : les logiques locales faces aux interventions internationales
Reyniers, Camille; Karsenty, Alain; Vermeulen, Cédric ULg

in Cahiers africains (2016), 87

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See detailA Comparison of 3D Methods for Identifying the Stance Phase in Treadmill Running for Both Rearfoot and Forefoot Runners
Deflandre, Dorian ULg; Schwartz, Cédric ULg; Weertz et al

in Journal of sports Science (2016), 4

We compared six 3D methods, OptoGait, and Myotest Run for the determination of contact time for runners with different foot strike patterns. Twenty male participants were divided into two groups: the heel ... [more ▼]

We compared six 3D methods, OptoGait, and Myotest Run for the determination of contact time for runners with different foot strike patterns. Twenty male participants were divided into two groups: the heel group, who attack the ground with the heel (n = 12), and the toe group, who attack the ground with the middle/front of the foot (n = 8). They performed trials at speeds of 8 km/h then 16 km/h. To detect foot strike, the use of peak velocity of 3D markers located on the heel, the fifth metatarsal, and the great toe provided the best results for both groups. To detect the toe off, the minimum vertical position of a 3D marker placed in line with the great toe gave the most satisfactory results for both groups. In this way, the values of contact time measured with the 3D methods are consistent. Values measured with OptoGait appear consistent too, while those of the Myotest Run underestimate the contact time for both speeds. 3D analysis provides interesting opportunities for calculation of contact time for both rearfoot and forefoot runners, using specific peak velocities to determine foot strike and marker displacement to determine toe off. [less ▲]

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See detailDESIGN AND MODELIZATION OF ACONVEX GRATING FOR AN HYPERSPECTRAL IMAGER OF THE CHANDRAYAAN 2 INSTRUMENT FOR THE MOON PROBE IN THE INFRARED
Sabushimike, Bernard ULg; Horugavye, Georges ULg; Piron, Pierre ULg et al

in International Journal of Latest Research in Science and Technology (2016), 5(2), 69-74

For hyperspectral imaging, diffraction gratings based spectrometers exhibit high spectral resolution and optical performance. Among those spectrometers, the Offner type (which consists of an entrance slit ... [more ▼]

For hyperspectral imaging, diffraction gratings based spectrometers exhibit high spectral resolution and optical performance. Among those spectrometers, the Offner type (which consists of an entrance slit, two concave mirrors and convex grating) offers a lot of advantages. In this paper, we propose the design and modelization of a convex grating which covers a spectral band ranging from 0.7 μm to 5 μm with a minimum diffraction efficiency of 20% at 800 nm, 50% at 3000 nm and 25% at 5000 nm. For a so wide band, a grating with a single blaze cannot satisfy these requirements. We will therefore propose an approach of multi-blaze grating which is subdivided into different sections each with its own blaze angle. Meanwhile, we perform the diffraction efficiency prediction using the scalar and rigorous theories to prove the compliance of this design with the technical specifications. The rigorous theory will also allow us to study the polarization sensitivity of this grating and the calculation of the diffraction efficiency of a grating with a profile degraded by manufacturing errors to assess the impact on the diffraction efficiency and the sensitivity to polarization [less ▲]

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See detailQuantification of four Isoflavones in Forages with UPLC®-MS/MS, using the Box-Behnken Experimental Design to Optimize Sample Preparation
Daems, Frédéric ULg; Romnee, Jean-Michel; Rasse, Catherine et al

in Chromatographia (2016), 79(11), 711-725

A performant method for the simultaneous quantification of daidzein, genistein, formononetin and biochanin A in forages using an UPLC®-MS/MS was developed and fully validated. The ultrasound-assisted ... [more ▼]

A performant method for the simultaneous quantification of daidzein, genistein, formononetin and biochanin A in forages using an UPLC®-MS/MS was developed and fully validated. The ultrasound-assisted extraction and enzymatic hydrolysis used in the sample preparation step were optimized using the Box-Behnken experimental design. The optimal extraction conditions used for a representative mix of forage plants were 80°C, 10 min and 55% methanol, and for hydrolysis they were 20°C, 18 h and pH=6. The chromatographic separation was achieved using an Acquity® UPLC® HSS T3 column, with a water/methanol linear gradient containing 0.01% of formic acid at a 0.55 mL min-1 flow rate. The four isoflavones were detected by ESI mass spectrometry in positive ion MRM mode. The method allows high throughput analyses of samples and showed an adequate linear regression model for all isoflavones over a range from 5 to 125 ng mL-1. There was good intra- and inter-day precision (≤ 8.2% and ≤ 7.6%) and accuracy (≤ 11.4% and ≤ 7.1%). The recovery rates were in an acceptable range of 70-120%, except for biochanin A, where the rate was about 50%. Good method repeatability was also observed, and there was no matrix effect or carry-over problem. The sample extracts were stable for at least 6 days of storage at -21°C and 6°C. The method proved to be sensitive, precise and accurate for discriminating a wide variety of forages likely to be grazed by ruminants according to their isoflavone content and to observe the impact storage process on isoflavone content in forages. [less ▲]

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See detailSensitivity of turbulent Schmidt number and turbulence model to simulations of jets in crossflow
Valero Huerta, Daniel ULg; Bung, Daniel B

in Environmental Modelling & Software (2016), 82

Environmental discharges have been traditionally designed by means of cost-intensive and timeconsuming experimental studies. Some extensively validated models based on an integral approach have been often ... [more ▼]

Environmental discharges have been traditionally designed by means of cost-intensive and timeconsuming experimental studies. Some extensively validated models based on an integral approach have been often employed for water quality problems, as recommended by USEPA (i.e.: CORMIX). In this study, FLOW-3D is employed for a full 3D RANS modelling of two turbulent jet-to-crossflow cases, including free surface jet impingement. Results are compared to both physical modelling and CORMIX to better assess model performance. Turbulence measurements have been collected for a better understanding of turbulent diffusion's parameter sensitivity. Although both studied models are generally able to reproduce jet trajectory, jet separation downstream of the impingement has been reproduced only by RANS modelling. Additionally, concentrations are better reproduced by FLOW-3D when the proper turbulent Schmidt number is used. This study provides a recommendation on the selection of the turbulence model and the turbulent Schmidt number for future outfall structures design studies. [less ▲]

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See detailOptical flow estimation in aerated flows
Bung, Daniel B.; Valero Huerta, Daniel ULg

in Journal of Hydraulic Research (2016)

Optical flow estimation is known from Computer Vision where it is used to determine obstacle movements through a sequence of images following an assumption of brightness conservation. This paper presents ... [more ▼]

Optical flow estimation is known from Computer Vision where it is used to determine obstacle movements through a sequence of images following an assumption of brightness conservation. This paper presents the first study on application of the optical flow method to aerated stepped spillway flows. For this purpose, the flow is captured with a high-speed camera and illuminated with a synchronized LED light source. The flow velocities, obtained using a basic Horn–Schunck method for estimation of the optical flow coupled with an image pyramid multi-resolution approach for image filtering, compare well with data from intrusive conductivity probe measurements. Application of the Horn–Schunck method yields densely populated flow field data sets with velocity information for every pixel. It is found that the image pyramid approach has the most significant effect on the accuracy compared to other image processing techniques. However, the final results show some dependency on the pixel intensity distribution, with better accuracy found for grey values between 100 and 150. [less ▲]

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See detailCrop residue management in arable cropping systems under temperate climate. Part 1: Soil biological and chemical (phosphorus and nitrogen) properties. A review
Lemtiri, Aboulkacem ULg; Degrune, Florine ULg; Barbieux, Sophie ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016)

Interacting soil organisms support biological processes that participate in soil functions, organic matter decomposition, and nutrient cycling. Earthworms and microorganisms play a range of beneficial ... [more ▼]

Interacting soil organisms support biological processes that participate in soil functions, organic matter decomposition, and nutrient cycling. Earthworms and microorganisms play a range of beneficial roles in agricultural systems, including increased organic matter mineralization, nutrient cycling, and soil structure stabilization. The following aspects of crop residue management effects are examined in this paper: (i) earthworm composition and structure; (ii) soil microbial communities; and (iii) phosphorus (P) and nitrogen (N) element availability and distribution in the soil profile. Conventional tillage (ploughing) is often reported to generate decreased soil organism abundance and diversity, primarily earthworms and microorganisms, as well as a uniform distribution of the nutrients P and N within the ploughed soil horizon. Soil residue incorporation of mineral particles can maintain P and N levels, however returning soil also increases aeration and the activation of microbial activity. Hence, comparisons of tillage effects on soil biological functioning and nutrient cycling remain unclear. This review highlights the challenges in establishing definitive evidence regarding the effects of crop residue management on soil organisms and nutrient dynamics. The studies examined reported variability in soil and climate, and the complexity of soil processes contributed to the absence of clear findings. Further research is required under temperate climate conditions. [less ▲]

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See detailAre BVOC exchanges in agricultural ecosystems overestimated? Insights from fluxes measured in a maize field over a whole growing season
Bachy, Aurélie ULg; Aubinet, Marc ULg; Schoon, Niels et al

in Atmospheric Chemistry and Physics (2016), 16(8),

Although maize is the second most important crop worldwide, and the most important C4 crop, no study on biogenic volatile organic compounds (BVOCs) has yet been conducted on this crop at ecosystem scale ... [more ▼]

Although maize is the second most important crop worldwide, and the most important C4 crop, no study on biogenic volatile organic compounds (BVOCs) has yet been conducted on this crop at ecosystem scale and over a whole growing season. This has led to large uncertainties in cropland BVOC emission estimations. This paper seeks to fill this gap by presenting, for the first time, BVOC fluxes measured in a maize field at ecosystem scale (using the disjunct eddy covariance by mass scanning technique) over a whole growing season in Belgium. The maize field emitted mainly methanol, although exchanges were bi-directional. The second most exchanged compound was acetic acid, which was taken up mainly in the growing season. Bi-directional exchanges of acetaldehyde, acetone and other oxygenated VOCs also occurred, whereas the terpenes, benzene and toluene exchanges were small, albeit significant. Surprisingly, BVOC exchanges were of the same order of magnitude on bare soil and on well developed vegetation, suggesting that soil is a major BVOC reservoir in agricultural ecosystems. Quantitatively, the maize BVOC emissions observed were lower than those reported in other maize, crops and grasses studies. The standard emission factors (SEFs) estimated in this study (231 ± 19 µg m−2 h−1 for methanol, 8 ± 5 µg m−2 h−1 for isoprene and 4 ± 6 µg m−2 h−1 for monoterpenes) were also much lower than those currently used by models for C4 crops, particularly for terpenes. These results suggest that maize fields are small BVOC exchangers in north-western Europe, with a lower BVOC emission impact than that modelled for growing C4 crops in this part of the world. They also reveal the high variability in BVOC exchanges across world regions for maize and suggest that SEFs should be estimated for each region separately. [less ▲]

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See detailWhat do selectorates seek? A comparative analysis of Belgian federal and regional candidate selection processes in 2014
Vandeleene, Audrey; Dodeigne, Jérémy ULg; De Winter, Lieven

in American Behavioral Scientist (2016), 60(7), 889-908

The 2014 “mother of all elections” in Belgium offers a unique opportunity to test whether candidate selection for regional and federal elections work alike or differently. The fact that Belgian ... [more ▼]

The 2014 “mother of all elections” in Belgium offers a unique opportunity to test whether candidate selection for regional and federal elections work alike or differently. The fact that Belgian “statewide” parties do not exist anymore and that Belgium is a quasi-closed list system, giving parties almost unlimited control over candidate selection enhances the uniqueness of the Belgian case. This article verifies whether these “regional” parties select candidates according to different methods for both elections and whether candidates for both elections display different attributes. Our exploratory analysis draws on in-depth interviews with party actors, on the 2014 Belgian Candidate Survey and on an extensive database of regional and federal parliamentary/executive careers since 1991. Our results show that selection procedures strongly differ across parties but hardly within parties regarding regional and federal elections. Besides, regarding candidates’ attributes, only few differences were found between levels. Hence, both levels seem to work alike. [less ▲]

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See detailUnderground pumped storage hydroelectricity using abandoned works (deep mines or open pits) and the impact on groundwater flow
Pujades, Estanislao ULg; Willems, Thibault ULg; Bodeux, Sarah ULg et al

in Hydrogeology Journal (2016), 24(6)

Underground pumped storage hydroelectricity (UPSH) plants using open-pit or deep mines can be used in flat regions to store the excess of electricity produced during low-demand energy periods. It is ... [more ▼]

Underground pumped storage hydroelectricity (UPSH) plants using open-pit or deep mines can be used in flat regions to store the excess of electricity produced during low-demand energy periods. It is essential to consider the interaction between UPSH plants and the surrounding geological media. There has been little work on the assessment of associated groundwater flow impacts. The impacts on groundwater flow are determined numerically using a simplified numerical model which is assumed to be representative of open-pit and deep mines. The main impact consists of oscillation of the piezometric head, and its magnitude depends on the characteristics of the aquifer/geological medium, the mine and the pumping and injection intervals. If an average piezometric head is considered, it drops at early times after the start of the UPSH plant activity and then recovers progressively. The most favorable hydrogeological conditions to minimize impacts are evaluated by comparing several scenarios. The impact magnitude will be lower in geological media with low hydraulic diffusivity; however, the parameter that plays the more important role is the volume of water stored in the mine. Its variation modifies considerably the groundwater flow impacts. Finally, the problem is studied analytically and some solutions are proposed to approximate the impacts, allowing a quick screening of favorable locations for future UPSH plants. [less ▲]

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See detailTropospheric water vapour isotopologue data (H216O, H218O and HD16O) as obtained from NDACC/FTIR solar absorption spectra
Barthlott, Sabine; Schneider, Matthias; Hase, Frank et al

in Earth System Science Data Discussions (2016)

We report on the ground-based FTIR (Fourier Transform InfraRed) tropospheric water vapour isotopologue remote sensing data that have been recently made available via the database of NDACC (Network for the ... [more ▼]

We report on the ground-based FTIR (Fourier Transform InfraRed) tropospheric water vapour isotopologue remote sensing data that have been recently made available via the database of NDACC (Network for the Detection of Atmospheric Composition Change; ftp://ftp.cpc.ncep.noaa.gov/ndacc/MUSICA/) and via doi:10.5281/zenodo.48902. Currently, data are available for 12 globally distributed stations. They have been centrally retrieved and quality filtered in the framework of the MUSICA project (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water). We explain particularities of retrieving the water vapour isotopologue state (vertical distribution of H162O, H182O and HD16O) and reveal the need for a new meta-data template for archiving such FTIR isotopologue data. We describe the format of different data components and give recommendations for correct data usage. Data are provided as two data types. The first type is best-suited for tropospheric water vapour distribution studies disregarding different isotopologues (comparison with radiosonde data, analyses of water vapour variability and trends, etc.). The second type is needed for analysing moisture pathways by means of {H2O,delta-D}-pair distributions. [less ▲]

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See detailNovel approaches for preventing acute graftversus- host disease after allogeneic hematopoietic stem cell transplantation
SERVAIS, Sophie ULg; BEGUIN, Yves ULg; Delens, Loïc ULg et al

in Expert Opinion on Investigational Drugs (2016), 9

Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) offers potential curative treatment for a wide range of malignant and nonmalignant hematological disorders. However, its success ... [more ▼]

Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) offers potential curative treatment for a wide range of malignant and nonmalignant hematological disorders. However, its success may be limited by post-transplant acute graft-versus-host disease (aGVHD), a systemic syndrome in which donor’s immune cells attack healthy tissues in the immunocompromised host. aGVHD is one of the main causes of morbidity and mortality after alloHSCT. Despite standard GVHD prophylaxis regimens, aGVHD still develops in approximately 40–60% of alloHSCT recipients. Areas covered In this review, after a brief summary of current knowledge on the pathogenesis of aGVHD, the authors review the current combination of a calcineurin inhibitor with an antimetabolite with or without added anti-thymocyte globulin (ATG) and emerging strategies for GVHD prevention. Expert opinion A new understanding of the involvement of cytokines, intracellular signaling pathways, epigenetics and immunoregulatory cells in GVHD pathogenesis will lead to new standards for aGVHD prophylaxis allowing better prevention of severe aGVHD without affecting graft-versus-tumor effects. [less ▲]

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See detailDaily intake and bacteriological quality of meat consumed in the households of Kigali, Rwanda
Niyonzima, Eugene ULg; Ongol, Martin Patrick; Brostaux, Yves ULg et al

in Food Control (2016), 69

Meat is consumed worldwide as a source of animal proteins, but it is recognized as one of the most important vehicles for food borne infections in humans. This study was conducted to determine the daily ... [more ▼]

Meat is consumed worldwide as a source of animal proteins, but it is recognized as one of the most important vehicles for food borne infections in humans. This study was conducted to determine the daily intake; the levels of hygiene indicator bacteria, namely the total mesophilic bacteria (TMC) and Escherichia coli counts (ECC); and the prevalence of Salmonella in meat consumed within the households of Kigali (Rwanda). The survey on meat consumption was carried out in 400 households by using a questionnaire, whereas the bacteriological analyses of meat samples were performed by using conventional culture methods. The results from the survey indicated that beef was the type of meat mostly consumed in Kigali city households, and the daily meat intake significantly varied with the social category of the household. No significant difference was observed between daily meat intakes in different age classes of household members. In the samples where microorganisms were detected, the average levels of TMCs and ECCs in raw meat were found to be 5.4 and 1.6 log cfu/g, respectively, whereas in cooked meat they were significantly reduced to 3.1 and 1.1 log cfu/g, respectively. The prevalence of Salmonella was reduced from 21.4% in raw meat to 3.4% in ready-to-eat cooked meat. Salmonella was not detected in cooked meat consumed in high-income households. The results from this study highlight the need for hygiene improvements in meat shops as well as in the households of Kigali, particularly those with low and medium incomes. [less ▲]

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See detailNo Evidence of Herpesvirus Infection in West Highland Terriers with Canine Idiopathic Pulmonary Fibrosis
Roels, Elodie ULg; Dourcy, Mickael ULg; Holopainen, S. et al

in Veterinary Pathology (2016)

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See detailDevelopment of the interfacial air layer in the non-aerated region of high-velocity spillway flows. Instabilities growth, entrapped air and influence on the self-aeration onset
Valero Huerta, Daniel ULg; Bung, Daniel B

in International Journal of Multiphase Flow (2016), 84

Self-aeration is traditionally explained by the water turbulent boundary layer outer edge intersection with the free surface. This paper presents a discussion on the commonly accepted hypothesis behind ... [more ▼]

Self-aeration is traditionally explained by the water turbulent boundary layer outer edge intersection with the free surface. This paper presents a discussion on the commonly accepted hypothesis behind the computation of the critical point of self-aeration in spillway flows and a new formulation is proposed based on the existence of a developing air flow over the free surface. Upstream of the inception point of self-aeration, some surface roughening has been often reported in previous studies which consequently implies some entrapped air transport and air–water flows coupling. Such air flow is proven in this study by presenting measured air velocities and computing the air boundary layer thickness for a 1V:2H smooth chute flow. Additionally, the growth rate of free surface waves has been analysed by means of Ultrasonic Sensors measurements, obtaining also the entrapped air concentration. High-speed camera imaging has been used for qualitative study of the flow perturbations. [less ▲]

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See detailMassive bleeding following severe blunt trauma: the first minutes that can change everything.
TONGLET, Martin ULg

in Acta Chirurgica Belgica (2016)

The first hour following a major trauma with massive bleeding is certainly the most decisive period in global trauma care. Most of it takes place during the prehospital care. Those prehospital minutes are ... [more ▼]

The first hour following a major trauma with massive bleeding is certainly the most decisive period in global trauma care. Most of it takes place during the prehospital care. Those prehospital minutes are thus determinant as they can be used to correctly identified patient’s clinical condition, initiate organization of the in-hospital needed resources and initiate specific therapies in the very early phase after trauma. Significant recent advances in this aspect of care have been made and but evidence to support some of those strategies is still lacking. [less ▲]

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See detailComments on: A random forest guided tour
Geurts, Pierre ULg; Wehenkel, Louis ULg

in TEST (2016), 25(2), 247-253

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See detailIn situ analysis of lipid oxidation in oilseedbased food products using near-infrared spectroscopy and chemometrics: The sunflower kernel paste (tahini) example
Mureșan; Danthine, Sabine ULg; Mureșan, Andruța Elena et al

in Talanta (2016), 155

A new near-infrared (NIR) spectroscopic method was developed for the analytical measurement of lipid oxidation in sunflower kernel paste (tahini), which was chosen as an example of a complex oilseed-based ... [more ▼]

A new near-infrared (NIR) spectroscopic method was developed for the analytical measurement of lipid oxidation in sunflower kernel paste (tahini), which was chosen as an example of a complex oilseed-based food product. The NIR spectra of sunflower tahini were acquired for the extracted fat phase (EFP) and for the intact sunflower tahini (IST) samples during controlled storage. The best peroxide value (PV) calibration models were considered suitable for quality control (ratio of performance of deviation [RPD] >5). The best PV partial least squares (PLS) model result for EFP (RPD 6.36) was obtained when using standard normal variate (SNV) and the Savitzky-Golay first derivative in the 1140-1184 nm, 1388-1440 nm and 2026-2194 nm regions. In the case of IST spectra, the best PV models (RPD 5.23) were obtained when either multiple scattering correction (MSC) or SNV were followed by the Savitzky-Golay second derivative for the 1148-1180 nm and 2064-2132 nm regions. There were poor correlations between the NIR-predicted values and the reference data of the panisidine value (pAV) for both EFP and IST. Overall, the results obtained showed that NIR spectroscopy is an appropriate analytical tool for monitoring sunflower paste PV in situ. Due to the nonexistence of the extraction step, it demonstrates a unique and substantial advantage over presently known methods. Based on these results it is strongly recommended that, when using NIR PLS models to assess lipid oxidation in situ in similar oilseedbased food products (e.g., sesame tahini, hazelnut and cocoa liquor used for chocolate production, peanut butter, hazelnut, almond, pistachio spreads), suitable calibration sets containing samples of different particle sizes and stored at different temperatures be selected. [less ▲]

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See detailNew paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.
Kleist, Andrew B.; Getschman, Anthony E.; Ziarek, Joshua J. et al

in Biochemical pharmacology (2016)

Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR signaling underpins numerous disease processes of the immune system and beyond. CKRs, which ... [more ▼]

Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR signaling underpins numerous disease processes of the immune system and beyond. CKRs, which belong to the seven transmembrane domain receptor (7TMR) superfamily, initiate signaling upon binding of endogenous, secreted chemokine ligands. Chemokine-CKR interactions are traditionally described by a two-step/two-site mechanism, in which the CKR N-terminus recognizes the chemokine globular core (i.e. site 1 interaction), followed by activation when the unstructured chemokine N-terminus is inserted into the receptor TM bundle (i.e. site 2 interaction). Several recent studies challenge the structural independence of sites 1 and 2 by demonstrating physical and allosteric links between these supposedly separate sites. Others contest the functional independence of these sites, identifying nuanced roles for site 1 and other interactions in CKR activation. These developments emerge within a rapidly changing landscape in which CKR signaling is influenced by receptor PTMs, chemokine and CKR dimerization, and endogenous non-chemokine ligands. Simultaneous advances in the structural and functional characterization of 7TMR biased signaling have altered how we understand promiscuous chemokine-CKR interactions. In this review, we explore new paradigms in CKR signal transduction by considering studies that depict a more intricate architecture governing the consequences of chemokine-CKR interactions. [less ▲]

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See detailFood in a row : urban trees offer valuable floral resources to pollinating insects
Somme, Laurent; Moquet, Laura; Quinet, Muriel et al

in Urban Ecosystems (2016)

Urbanization affects the availability and diversity of floral resources (pollen and/or nectar) for wild pollinating insects. For example, urban green areas are characterized by an abundance of ornamental ... [more ▼]

Urbanization affects the availability and diversity of floral resources (pollen and/or nectar) for wild pollinating insects. For example, urban green areas are characterized by an abundance of ornamental plant species. Increasingly, trees are planted to improve the aesthetics of urban streets and parks. These urban trees might offer important floral resources to pollinating insects. To examine the suitability of urban trees as resources for pollinating insects, we investigated the chemical composition of pollen and nectar as well as the amount of nectar produced by the nine major insect-pollinated tree species planted in cities of Western Europe, namely Acer pseudoplatanus, Aesculus carnea, A. hippocastanum, Robinia pseudoacacia, Tilia cordata, T. x euchlora, T. x europaea, T. platyphyllos and T. tomentosa. The analyses revealed that globally the Tilia trees provide pollen with lower contents of polypeptides, amino acids and phytosterols compared with the other species. Urban tree flowers offer abundant nectar with relatively high sugar contents (0.16–1.28 mg/flower); sucrose was the predominant sugar in all nectars. The investigated tree species could therefore be considered in future city plantings. [less ▲]

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See detailThe Science, development, and commercialization of postharvest biocontrol products
Droby, Samir; Wisniewski, Michael; Teixido, Neus et al

in Postharvest Biology & Technology (2016), 122

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See detailTowards regenerative and positive impact architecture: A comparison of two net zero energy buildings
Attia, Shady ULg

in Sustainable Cities and Society (2016), 26(2016), 393-406

Abstract Regenerative design holds great promise for a new era of sustainable and positive impact architecture, sparking considerable interest among architects, building professionals and their clients ... [more ▼]

Abstract Regenerative design holds great promise for a new era of sustainable and positive impact architecture, sparking considerable interest among architects, building professionals and their clients. However, the translational arm of regenerative design in practice is in a relatively primitive state. Although a number of theoretical definitions and studies have been initiated, the early returns point to several inherent application problems. In this regard, the professional and scientific potential of regenerative architecture can only be fully realized by the identification of the key barriers to projects design, construction and operation. In this paper, we compare two state of the art buildings to address the critical steps in the transition from the negative impact reduction architecture to the positive impact regenerative architecture, utilizing life cycle analysis. The case studies analysis and comparison can serve as an inspiring eye opener and provide a vision for architects and building professionals in the fields of high performance buildings and regenerative architecture. [less ▲]

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See detailFire Fragility Curves for Steel Buildings in a Community Context: A Methodology
Gernay, Thomas ULg; Elhami Khorasani, Negar; Garlock, Maria

in Engineering Structures (2016), 113

This paper proposes a novel methodology for developing fire fragility functions for an entire steel building - meaning that the function is not specific to a location within the building. The aim is to ... [more ▼]

This paper proposes a novel methodology for developing fire fragility functions for an entire steel building - meaning that the function is not specific to a location within the building. The aim is to characterize the probabilistic vulnerability of steel buildings to fire in the context of community resilience assessment. In developing the fragility functions, uncertainties in the fire model, the heat transfer model and the thermo-mechanical response are considered. In addition several fire scenarios at different locations in the building are studied. Monte Carlo Simulations and Latin Hypercube Sampling are used to generate the probability distributions of demand placed on the members and structural capacity relative to selected damage thresholds. By assessing demand and capacity in the temperature domain, the thermal and the structural problems can be treated separately to improve the efficiency of the probabilistic analysis. After the probability distributions are obtained for demand and capacity, the fragility functions can be obtained by convolution of the distributions. Finally, event tree analysis is used to combine the functions associated with fire scenarios in different building locations. The developed fire fragility functions yield the probability of exceedance of predefined damage states as a function of the fire load in the building. The methodology is illustrated on an example consisting in a prototype nine-story steel building based on the SAC project. [less ▲]

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See detailHighly-active Pd-Cu electrocatalysts for oxidation of ubiquitous oxygenated fuels
Serov, Alexey; Asset, Tristan ULg; Padilla, Monica et al

in Applied Catalysis B : Environmental (2016)

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See detailFrom Near-Infrared and Raman to Surface-Enhanced Raman Spectroscopy: Progress, Limitations, Perspectives in Bioanalysis
Dumont, Elodie ULg; De Bleye, Charlotte ULg; Sacre, Pierre-Yves ULg et al

in Bioanalysis (2016), 8(10), 1077-1103

Over recent decades, spreading environmental concern entailed the expansion of green chemistry analytical tools. Vibrational spectroscopy, belonging to this class of analytical tool, is particularly ... [more ▼]

Over recent decades, spreading environmental concern entailed the expansion of green chemistry analytical tools. Vibrational spectroscopy, belonging to this class of analytical tool, is particularly interesting taking into account its numerous advantages such as fast data acquisition and no sample preparation. In this context, Near-Infrared, Raman and mainly Surface-Enhanced Raman Spectroscopy (SERS) have thus gained interest in many fields including bioanalysis. The two former techniques only ensure the analysis of concentrated compounds in simple matrices, whereas the emergence of SERS improved the performances of vibrational spectroscopy to very sensitive and selective analyses. Complex SERS substrates were also developed enabling biomarker measurements, paving the way for SERS immunoassays. Therefore, in this paper, the strengths and weaknesses of these techniques will be highlighted with a focus on recent progress. [less ▲]

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See detailPour une rhétorique sémiotique de l’image en sciences biologiques
Dondero, Maria Giulia ULg

in Argumentation et Analyse du Discours (2016), 16(1), 1-18

This article examines the rhetoric of images in the biological sciences. The epistemological context of our study is found in Bruno Latour’s sociology of science and Françoise Bastide’s semiotics of ... [more ▼]

This article examines the rhetoric of images in the biological sciences. The epistemological context of our study is found in Bruno Latour’s sociology of science and Françoise Bastide’s semiotics of scientific images, in the theory and methodology of post-Greimassian discourse semiotics, and in the rhetorical theories of Groupe µ and Jean-François Bordron. We use these different perspectives in an analysis of rhetorical operations (addition, deletion, selection, superposition, and more) performed by laboratory scientists, as represented in our corpus of images. Our particular focus is on a rhetoric that is “mereological”, so named because it is based on the relation between the whole and the parts. [less ▲]

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See detailDirect one-pot synthesis of poly(ionic liquid) nanogels by cobalt-mediated radical cross-linking copolymerization in organic or aqueous media
Weiss-Maurin, Mathilde ULg; Cordella, Daniela ULg; Jérôme, Christine ULg et al

in Polymer Chemistry (2016), 7(14), 2521-2530

Nanogels of controlled kinetic chain length were synthesized by cobalt-mediated radical cross-linking copolymerization (CMRccP) involving a vinyl monomer and a divinyl cross-linker. This strategy was ... [more ▼]

Nanogels of controlled kinetic chain length were synthesized by cobalt-mediated radical cross-linking copolymerization (CMRccP) involving a vinyl monomer and a divinyl cross-linker. This strategy was first validated to achieve neutral poly(vinyl acetate) nanogels by CMRccP of vinyl acetate and divinyl adipate as cross-linker, at 40 °C, in presence of an alkyl- cobalt(III) serving both as initiator and controlling agent, using ethyl acetate as solvent. Poly(ionic liquid) nanogels were then directly obtained by CMRccP of N-vinyl-3-ethyl imidazolium bromide, in presence of 1,13-divinyl-3-decyl diimidazolium bromide as cross-linker. CMRccP experiments could be conducted either in organic solvent using dimethyl formamide or, more interestingly, in aqueous solution, demonstrating the robustness and the versatility of this one-step process. Chain extensions of PILs nanogels were also carried out in water, forming core-shell structures, thus opening new avenues in the design of functional nanogels. [less ▲]

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See detailNew 2016 MeSH addressing information gap, poverty, violence and danger of medicine set the tone for policy makers in patient care
Jamoulle, Marc ULg

in International Journal of Health Policy and Management (2016)

A careful review of the list of newly published Medical subject Heading in 2016 allows to identify 52 new or updated MESH in 2016 relevant to General Practice Family Medicine management (i.e. non-clinical ... [more ▼]

A careful review of the list of newly published Medical subject Heading in 2016 allows to identify 52 new or updated MESH in 2016 relevant to General Practice Family Medicine management (i.e. non-clinical) fields. Information society gap, poverty, violence and quaternary prevention related MeSH are outstandingly frequent. The 52 identified MeSH are proposed in supplementary material. [less ▲]

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See detailLow-rank plus sparse decomposition for exoplanet detection in direct-imaging ADI sequences. The LLSG algorithm
Gómez González, Carlos ULg; Absil, Olivier ULg; Absil, P.-A. et al

in Astronomy and Astrophysics (2016), 589

Context. Data processing constitutes a critical component of high-contrast exoplanet imaging. Its role is almost as important as the choice of a coronagraph or a wavefront control system, and it is ... [more ▼]

Context. Data processing constitutes a critical component of high-contrast exoplanet imaging. Its role is almost as important as the choice of a coronagraph or a wavefront control system, and it is intertwined with the chosen observing strategy. Among the data processing techniques for angular differential imaging (ADI), the most recent is the family of principal component analysis (PCA) based algorithms. It is a widely used statistical tool developed during the first half of the past century. PCA serves, in this case, as a subspace projection technique for constructing a reference point spread function (PSF) that can be subtracted from the science data for boosting the detectability of potential companions present in the data. Unfortunately, when building this reference PSF from the science data itself, PCA comes with certain limitations such as the sensitivity of the lower dimensional orthogonal subspace to non-Gaussian noise. <BR /> Aims: Inspired by recent advances in machine learning algorithms such as robust PCA, we aim to propose a localized subspace projection technique that surpasses current PCA-based post-processing algorithms in terms of the detectability of companions at near real-time speed, a quality that will be useful for future direct imaging surveys. <BR /> Methods: We used randomized low-rank approximation methods recently proposed in the machine learning literature, coupled with entry-wise thresholding to decompose an ADI image sequence locally into low-rank, sparse, and Gaussian noise components (LLSG). This local three-term decomposition separates the starlight and the associated speckle noise from the planetary signal, which mostly remains in the sparse term. We tested the performance of our new algorithm on a long ADI sequence obtained on β Pictoris with VLT/NACO. <BR /> Results: Compared to a standard PCA approach, LLSG decomposition reaches a higher signal-to-noise ratio and has an overall better performance in the receiver operating characteristic space. This three-term decomposition brings a detectability boost compared to the full-frame standard PCA approach, especially in the small inner working angle region where complex speckle noise prevents PCA from discerning true companions from noise. [less ▲]

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See detailInventaire et mise en collection d’espèces de pucerons et de parasitoïdes collectés en grandes cultures, et premier enregistrement de Metopolophium frisicum (Hille Ris Lambers 1947) et Acyrthosiphon primulae (Theobald 1913) (Hemiptera: Aphididae) en Belgique
Chevalier Mendes Lopes, Thomas ULg; Hatt, Séverin ULg; Starý, Petr et al

in Entomologie Faunistique = Faunistic Entomology (2016), 69

The purpose of this study was to identify aphid and parasitoid species that were collected in wheat and pea crops situated in Gembloux (Belgium), and conserve them into collections. To do so, yellow traps ... [more ▼]

The purpose of this study was to identify aphid and parasitoid species that were collected in wheat and pea crops situated in Gembloux (Belgium), and conserve them into collections. To do so, yellow traps (von Moericke) were used during 2012, 2013 and 2014 growing seasons. Fifty-two aphid species were identified and conserved in the entomological Conservatory of Gembloux. Among them, Metopolophium frisicum (Hille Ris Lambers 1947) and Acyrthosiphon primulae (Theobald 1913) were officially referenced for the first time in Belgium. Moreover, a collection composed by 16 parasitoid species was created. Their interest for biological control, as well as the methods that are studied in the laboratory of functional and evolutionary Entomology from Gembloux Agro-Bio Tech (University of Liège) to promote their presence in crops are discussed. [less ▲]

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See detailAnthropogenic forcing dominates global mean sea-level rise since 1970
Slagen, A.; Church, J.; Agosta, Cécile ULg et al

in Nature Climate Change (2016)

Sea-level change is an important consequence of anthropogenic climate change, as higher sea levels increase the frequency of sea-level extremes and the impact of coastal flooding and erosion on the ... [more ▼]

Sea-level change is an important consequence of anthropogenic climate change, as higher sea levels increase the frequency of sea-level extremes and the impact of coastal flooding and erosion on the coastal environment, infrastructure and coastal communities1, 2. Although individual attribution studies have been done for ocean thermal expansion3, 4 and glacier mass loss5, two of the largest contributors to twentieth-century sea-level rise, this has not been done for the other contributors or total global mean sea-level change (GMSLC). Here, we evaluate the influence of greenhouse gases (GHGs), anthropogenic aerosols, natural radiative forcings and internal climate variability on sea-level contributions of ocean thermal expansion, glaciers, ice-sheet surface mass balance and total GMSLC. For each contribution, dedicated models are forced with results from the Coupled Model Intercomparison Project Phase 5 (CMIP5) climate model archive6. The sum of all included contributions explains 74 ± 22% (±2σ) of the observed GMSLC over the period 1900–2005. The natural radiative forcing makes essentially zero contribution over the twentieth century (2 ± 15% over the period 1900–2005), but combined with the response to past climatic variations explains 67 ± 23% of the observed rise before 1950 and only 9 ± 18% after 1970 (38 ± 12% over the period 1900–2005). In contrast, the anthropogenic forcing (primarily a balance between a positive sea-level contribution from GHGs and a partially offsetting component from anthropogenic aerosols) explains only 15 ± 55% of the observations before 1950, but increases to become the dominant contribution to sea-level rise after 1970 (69 ± 31%), reaching 72 ± 39% in 2000 (37 ± 38% over the period 1900–2005). [less ▲]

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See detailMANAGEMENT OF ENDOCRINE DISEASE: Pituitary "incidentaloma": Neuroradiological assessment and differential diagnosis.
Vasilev, Vladimir; Rostomyan, Liliya ULg; Daly, Adrian ULg et al

in European Journal of Endocrinology (2016), 175(4), 171184

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See detailCO2-blown microcellular non-isocyanate polyurethane (NIPU) foams: from bio- and CO2-sourced monomers to potentially thermal insulating materials
Grignard, Bruno ULg; Thomassin, Jean-Michel ULg; Gennen, Sandro ULg et al

in Green Chemistry (2016), 18(7), 2206-2215

Bio- and CO2-sourced non-isocyanate polyurethane (NIPU) microcellular foams were prepared using supercritical carbon dioxide (scCO2) foaming technology. These low-density foams offer low thermal ... [more ▼]

Bio- and CO2-sourced non-isocyanate polyurethane (NIPU) microcellular foams were prepared using supercritical carbon dioxide (scCO2) foaming technology. These low-density foams offer low thermal conductivity and have an impressive potential for use in insulating materials. They constitute attractive alternatives to conventional polyurethane foams. We investigated CO2’s ability to synthesize the cyclic carbonates that are used in the preparation of NIPU by melt step-growth polymerization with a bio-sourced amino-telechelic oligoamide and for NIPU foaming. Our study shows that CO2 is not only sequestered in the material for long-term application, but is also valorized as a blowing agent in the production of NIPU foams. Such foams will contribute to energy conservation and savings by reducing CO2 emissions. [less ▲]

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See detailEvaluating ethane and methane emissions associated with the development of oil and natural gas extraction in North America
Franco, Bruno ULg; Mahieu, Emmanuel ULg; Emmons, L. K. et al

in Environmental Research Letters (2016), 11(4), 044010

Sharp rises in the atmospheric abundance of ethane (C2H6) have been detected from 2009 onwards in the Northern Hemisphere as a result of the unprecedented growth in the exploitation of shale gas and tight ... [more ▼]

Sharp rises in the atmospheric abundance of ethane (C2H6) have been detected from 2009 onwards in the Northern Hemisphere as a result of the unprecedented growth in the exploitation of shale gas and tight oil reservoirs in North America. Using time series of C2H6 total columns derived from ground-based FTIR observations made at five selected NDACC sites, we characterize the recent C2H6 evolution and determine growth rates of ~5%/yr at mid-latitudes and of ~3%/yr at remote sites. Results from CAM-chem simulations with the HTAP2 bottom-up inventory for anthropogenic emissions are found to greatly underestimate the current C2H6 abundances. Doubling global emissions is required to reconcile the simulations and the observations prior to 2009. We further estimate that North American anthropogenic C2H6 emissions have increased from 1.6 Tg/yr in 2008 to 2.8 Tg/yr in 2014, i.e. by 75% over these six years. We also completed a second simulation with new top-down emissions of C2H6 from North American oil and gas activities, biofuel consumption and biomass burning, inferred from space-borne observations of methane (CH4) from GOSAT. In this simulation, GEOS-Chem is able to reproduce FTIR measurements at the mid-latitudinal sites, underscoring the impact of the North American oil and gas development on the current C2H6 abundance. Finally we estimate that the North American oil and gas emissions of CH4, a major greenhouse gas, grew from 20 to 35 Tg/yr over the period 2008 to 2014, in association with the recent C2H6 rise. [less ▲]

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See detailDevelopment of solid-supported methodology for the preparation of peptidoglycan fragments containing (2S,6R)-diaminopimelic acid
Simon, Justine ULg; Lamborelle, Nicolas ULg; Zervosen, Astrid et al

in Tetrahedron Letters (2016)

Herein, we describe the development of an efficient solid-supported methodology for the stereoselective synthesis of two peptides containing (2S,6R)-diaminopimelic acid, (S)-Ala-γ-(R)-Glu-(2S,6R)-A2pm-(R ... [more ▼]

Herein, we describe the development of an efficient solid-supported methodology for the stereoselective synthesis of two peptides containing (2S,6R)-diaminopimelic acid, (S)-Ala-γ-(R)-Glu-(2S,6R)-A2pm-(R)-Ala 1 and γ-(R)-Glu-(2S,6R)-A2pm 2. The platform consists of a Wang resin anchored by an amino acid chain including allylglycine. By olefin cross metathesis with vinylglycine, unsaturated protected (2S,6R)-A2pm was fixed on solid support. Peptides were achieved by cleavage of cross metathesis products from resin, followed by reduction of double bonds along removing of protecting groups. Furthermore, this efficient solid phase approach will lead to peptide and muropeptide libraries. [less ▲]

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See detailReconstruction and analysis of long-term satellite-derived sea surface temperature for the South China Sea
Huynh, Thi Hong Ngu ULg; Alvera Azcarate, Aïda ULg; Barth, Alexander ULg et al

in Journal of Oceanography (2016)

Sea surface temperature (SST) is one of the key variables often used to investigate ocean dynamics, ocean-atmosphere interaction, and climate change. Unfortunately, the SST data sources in the South China ... [more ▼]

Sea surface temperature (SST) is one of the key variables often used to investigate ocean dynamics, ocean-atmosphere interaction, and climate change. Unfortunately, the SST data sources in the South China Sea (SCS) are not abundant due to sparse measurements of in situ SST and a high percentage of missing data in the satellite-derived SST. Therefore, SST data sets with low resolution and/or a short-term period have often been used in previous researches. Here we used Data INterpolating Empirical Orthogonal Functions, a self-consistent and parameter-free method for filling in missing data, to reconstruct the daily nighttime 4-km AVHRR Pathfinder SST for the long-term period spanning from 1989 to 2009. In addition to the reconstructed field, we also estimated the local error map for each reconstructed image. Comparisons between the reconstructed and other data sets (satellite-derived microwave and in situ SSTs) show that the results are reliable for use in many different researches, such as validating numerical models, or identifying and tracking meso-scale oceanic features. Moreover, the Empirical Orthogonal Function (EOF) analysis of the reconstructed SST and the reconstructed SST anomalies clearly shows the subseasonal, seasonal, and interannual variability of SST under the influence of monsoon and El Niño-Southern Oscillation (ENSO), as well as reveals some oceanic features that could not be captured well in previous EOF analyses. The SCS SST often lags ENSO by about half a year. However, in this study, we see that the time lag changes with the frequencies of the SST variability, from 1 to 6 months. [less ▲]

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See detailDetailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?
Demarche, Sophie ULg; SCHLEICH, FLorence ULg; HENKET, Monique ULg et al

in BMC Pulmonary Medicine (2016), 16

BACKGROUND: The technique of induced sputum has allowed to subdivide asthma patients into inflammatory phenotypes according to their level of granulocyte airway infiltration. There are very few studies ... [more ▼]

BACKGROUND: The technique of induced sputum has allowed to subdivide asthma patients into inflammatory phenotypes according to their level of granulocyte airway infiltration. There are very few studies which looked at detailed sputum and blood cell counts in a large cohort of asthmatics divided into inflammatory phenotypes. The purpose of this study was to analyze sputum cell counts, blood leukocytes and systemic inflammatory markers in these phenotypes, and investigate how those groups compared with healthy subjects. METHODS: We conducted a retrospective cross-sectional study on 833 asthmatics recruited from the University Asthma Clinic of Liege and compared them with 194 healthy subjects. Asthmatics were classified into inflammatory phenotypes. RESULTS: The total non-squamous cell count per gram of sputum was greater in mixed granulocytic and neutrophilic phenotypes as compared to eosinophilic, paucigranulocytic asthma and healthy subjects (p < 0.005). Sputum eosinophils (in absolute values and percentages) were increased in all asthma phenotypes including paucigranulocytic asthma, compared to healthy subjects (p < 0.005). Eosinophilic asthma showed higher absolute sputum neutrophil and lymphocyte counts than healthy subjects (p < 0.005), while neutrophilic asthmatics had a particularly low number of sputum macrophages and epithelial cells. All asthma phenotypes showed an increased blood leukocyte count compared to healthy subjects (p < 0.005), with paucigranulocytic asthmatics having also increased absolute blood eosinophils compared to healthy subjects (p < 0.005). Neutrophilic asthma had raised CRP and fibrinogen while eosinophilic asthma only showed raised fibrinogen compared to healthy subjects (p < 0.005). CONCLUSIONS: This study demonstrates that a significant eosinophilic inflammation is present across all categories of asthma, and that paucigranulocytic asthma may be seen as a low grade inflammatory disease. [less ▲]

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See detailAs above, so below? Narrative Salience and Side Effects of National Innovation Systems
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Critical Policy Studies (2016)

This article furthers previous attempts at integrating narratology in policy analysis. Embracing an open-ended definition of narrative, it stresses the importance of maintaining distinct narrative levels ... [more ▼]

This article furthers previous attempts at integrating narratology in policy analysis. Embracing an open-ended definition of narrative, it stresses the importance of maintaining distinct narrative levels and, more generally, of taking into account the pragmatic dimension of narration as an activity, including the often-implicit role and focalization of the policy analyst. Developing a conceptual analogy between storytelling and the exercise of power, it argues for a critical use of practical imagination in ‘cold’ situations of ‘narrative salience’, characterized by the absence of controversy or uncertainty, an uneven distribution of the power of scenarization. These propositions for a ‘revisited’ approach to policy narratives, equidistant from the positivist and post-positivist dichotomy, are tested on the case of ‘narrative salience’ where a particular storyline, national innovation systems, is so dominant that there appears to be no ‘counter-story’. [less ▲]

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See detailEnrichment of Central African logged forests with high-value tree species: testing a new approach to regenerating degraded forests
Doucet, Jean-Louis ULg; Daïnou, Kasso ULg; Ligot, Gauthier ULg et al

in International Journal of Biodiversity Science, Ecosystem Services and Management (2016)

In natural forests of Central Africa, several studies indicate a dramatic decrease in commercial trees, including species of concern for conservation. Enrichment planting with these species will favor ... [more ▼]

In natural forests of Central Africa, several studies indicate a dramatic decrease in commercial trees, including species of concern for conservation. Enrichment planting with these species will favor both the long-term recovery of their populations and biodiversity conservation in logged forests. In this study, we analyzed the survival and growth of 23 species in plantations. Fourteen 0.2–1.1 ha mixed species plantations consisting of single-species 15 × 15 m blocks were studied for 5 years in a logging concession of southeastern Cameroon. The plantation design considered both species light requirements and sensitivity to damage by pests. To identify the best species for enrichment planting, we assessed both species performance and plantation costs. We also tested for relationships between species traits and species performance. Mean annual diameter growth increments ranged from 1.67 to 42.9 mm. No significant relationship was found between growth and survival. Herbivory by wild Bovidae was the main cause of mortality and should be carefully considered in rehabilitation efforts. We found a significant negative relationship between wood density and maximum growth rate. The other traits tested were not good predictors of species performance in plantations. The two best-performing species, Triplochiton scleroxylon and Terminalia superba, could reach the minimum cutting diameter during a 30-year cutting cycle. Costs were high and mechanized site preparation is suggested to reduce them. Widespread adoption of such plantations will only occur if financial incentives or national regulations for assuring regeneration are implemented. [less ▲]

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See detailObservational signatures of past mass-exchange episodes in massive binaries: The case of HD 149 404
Raucq, Françoise ULg; Rauw, Gregor ULg; Gosset, Eric ULg et al

in Astronomy and Astrophysics (2016), 588

Context. Mass and momentum exchanges in close massive binaries play an important role in their evolution, and produce several observational signatures such as asynchronous rotation and altered chemical ... [more ▼]

Context. Mass and momentum exchanges in close massive binaries play an important role in their evolution, and produce several observational signatures such as asynchronous rotation and altered chemical compositions, that remain after the stars detach again. Aims: We investigated these effects for the detached massive O-star binary HD 149 404 (O7.5 If + ON9.7 I, P = 9.81 days), which is thought to have experienced a past episode of case A Roche-lobe overflow (RLOF). Methods: Using phase-resolved spectroscopy, we performed the disentangling of the optical spectra of the two stars. The reconstructed primary and secondary spectra were then analysed with the CMFGEN model atmosphere code to determine stellar parameters, such as the effective temperatures and surface gravities, and to constrain the chemical composition of the components. We complemented the optical study with the study of IUE spectra, which we compare to the synthetic binary spectra. The properties of the stars were compared to evolutionary models. Results: We confirmed a strong overabundance in nitrogen ([N/C] ~ 150[N/C][SUB]⊙[/SUB]) for the secondary and a slight nitrogen overabundance ([N/C] ~ 5[N/C][SUB]⊙[/SUB]) for the primary star. Comparing the two stars, we found evidence for asynchronous rotation, with a rotational period ratio of 0.50 ± 0.11. Conclusions: The hypothesis of a past case A RLOF interaction in HD 149 404 is most plausible to explain its chemical abundances and rotational asynchronicity. Some of the observed properties, such as the abundance pattern, are clearly a challenge for current case A binary evolution models, however. [less ▲]

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See detailTesting the theory of colliding winds: the periastron passage of 9 Sagittarii. I. X-ray and optical spectroscopy
Rauw, Grégor ULg; Blomme, R.; Nazé, Yaël ULg et al

in Astronomy and Astrophysics (2016), 589

Context. The long-period, highly eccentric O-star binary 9 Sgr, known for its non-thermal radio emission and its relatively bright X-ray emission, went through its periastron in 2013. <BR /> Aims: Such an ... [more ▼]

Context. The long-period, highly eccentric O-star binary 9 Sgr, known for its non-thermal radio emission and its relatively bright X-ray emission, went through its periastron in 2013. <BR /> Aims: Such an event can be used to observationally test the predictions of the theory of colliding stellar winds over a broad range of wavelengths. <BR /> Methods: We conducted a multi-wavelength monitoring campaign of 9 Sgr around the 2013 periastron. In this paper, we focus on X-ray observations and optical spectroscopy. <BR /> Results: The optical spectra allow us to revisit the orbital solution of 9 Sgr and to refine its orbital period to 9.1 years. The X-ray flux is maximum at periastron over all energy bands, but with clear differences as a function of energy. The largest variations are observed at energies above 2 keV, whilst the spectrum in the soft band (0.5-1.0 keV) remains mostly unchanged, indicating that it arises far from the collision region, in the inner winds of the individual components. The level of the hard emission at periastron clearly deviates from the 1 /r relation expected for an adiabatic wind-interaction zone, whilst this relation seems to hold at the other phases that are covered by our observations. The spectra taken at phase 0.946 reveal a clear Fe xxv line at 6.7 keV, but no such line is detected at periastron (φ = 0.000), although a simple model predicts a strong line that should be easily visible in the data. <BR /> Conclusions: The peculiarities of the X-ray spectrum of 9 Sgr could reflect the effect of radiative inhibition as well as a phase-dependent efficiency of particle acceleration on the shock properties. [less ▲]

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See detailBrief communication: Two well-marked cases of aerodynamic adjustment of sastrugi
Amory, Charles ULg; Naaim-Bouvet, Florence; Gallée, Hubert et al

in Cryosphere (The) (2016)

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See detailDiscovering novel enzymes y functional screening of plurigenomic libraries from alga-associated Flavobacteriia and Gammaproteobacteria
Martin, Marjolaine ULg; Vandermies, Marie ULg; Joyeux, Coline et al

in Microbiological Research (2016), 186

Alga-associated microorganisms, in the context of their numerous interactions with the host and thecomplexity of the marine environment, are known to produce diverse hydrolytic enzymes with ... [more ▼]

Alga-associated microorganisms, in the context of their numerous interactions with the host and thecomplexity of the marine environment, are known to produce diverse hydrolytic enzymes with originalbiochemistry. We recently isolated several macroalgal-polysaccharide-degrading bacteria from the sur-face of the brown alga Ascophyllum nodosum. These active isolates belong to two classes: the Flavobacteriiaand the Gammaproteobacteria. In the present study, we constructed two “plurigenomic” (with multi-ple bacterial genomes) libraries with the 5 most interesting isolates (regarding their phylogeny andtheir enzymatic activities) of each class (Fv and Gm libraries). Both libraries were screened for diversehydrolytic activities. Five activities, out of the 48 previously identified in the natural polysaccharolyticisolates, were recovered by functional screening: a xylanase (GmXyl7), a beta-glucosidase (GmBg1), anesterase (GmEst7) and two iota-carrageenases (Fvi2.5 and Gmi1.3). We discuss here the potential role ofthe used host-cell, the average DNA insert-sizes and the used restriction enzymes on the divergent screen-ing yields obtained for both libraries and get deeper inside the “great screen anomaly”. Interestingly, thediscovered esterase probably stands for a novel family of homoserine o-acetyltransferase-like-esterases,while the two iota-carrageenases represent new members of the poorly known GH82 family (contain-ing only 19 proteins since its description in 2000). These original results demonstrate the efficiencyof our uncommon “plurigenomic” library approach and the underexplored potential of alga-associatedcultivable microbiota for the identification of novel and algal-specific enzymes. [less ▲]

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See detailDistant activity of 67P/Churyumov-Gerasimenko in 2014: Ground-based results during the Rosetta pre-landing phase
Snodgrass, Colin; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2016), 588

Context. As the ESA Rosetta mission approached, orbited, and sent a lander to comet 67P/Churyumov-Gerasimenko in 2014, a large campaign of ground-based observations also followed the comet. <BR /> Aims ... [more ▼]

Context. As the ESA Rosetta mission approached, orbited, and sent a lander to comet 67P/Churyumov-Gerasimenko in 2014, a large campaign of ground-based observations also followed the comet. <BR /> Aims: We constrain the total activity level of the comet by photometry and spectroscopy to place Rosetta results in context and to understand the large-scale structure of the comet's coma pre-perihelion. <BR /> Methods: We performed observations using a number of telescopes, but concentrate on results from the 8 m VLT and Gemini South telescopes in Chile. We use R-band imaging to measure the dust coma contribution to the comet's brightness and UV-visible spectroscopy to search for gas emissions, primarily using VLT/FORS. In addition we imaged the comet in near-infrared wavelengths (JHK) in late 2014 with Gemini-S/Flamingos-2. <BR /> Results: We find that the comet was already active in early 2014 at heliocentric distances beyond 4 au. The evolution of the total activity (measured by dust) followed previous predictions. No gas emissions were detected despite sensitive searches. <BR /> Conclusions: The comet maintains a similar level of activity from orbit to orbit, and is in that sense predictable, meaning that Rosetta results correspond to typical behaviour for this comet. The gas production (for CN at least) is highly asymmetric with respect to perihelion, as our upper limits are below the measured production rates for similar distances post-perihelion in previous orbits. Based on observations made with ESO telescopes at the La Silla Paranal Observatory under programme IDs 592.C-0924, 093.C-0593, 094.C-0054, and at Gemini South under GS-2014B-Q-15 and GS-2014B-Q-76. [less ▲]

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See detailThe Sun as a planet-host star: proxies from SDO images for HARPS radial-velocity variations
Haywood, R. D.; Collier Cameron, A.; Unruh, Y. C. et al

in Monthly Notices of the Royal Astronomical Society (2016), 457

The Sun is the only star whose surface can be directly resolved at high resolution, and therefore constitutes an excellent test case to explore the physical origin of stellar radial-velocity (RV ... [more ▼]

The Sun is the only star whose surface can be directly resolved at high resolution, and therefore constitutes an excellent test case to explore the physical origin of stellar radial-velocity (RV) variability. We present HARPS observations of sunlight scattered off the bright asteroid 4/Vesta, from which we deduced the Sun's activity-driven RV variations. In parallel, the Helioseismic and Magnetic Imager instrument on board the Solar Dynamics Observatory provided us with simultaneous high spatial resolution magnetograms, Dopplergrams and continuum images of the Sun in the Fe I 6173 Å line. We determine the RV modulation arising from the suppression of granular blueshift in magnetized regions and the flux imbalance induced by dark spots and bright faculae. The rms velocity amplitudes of these contributions are 2.40 and 0.41 m s[SUP]-1[/SUP], respectively, which confirms that the inhibition of convection is the dominant source of activity-induced RV variations at play, in accordance with previous studies. We find the Doppler imbalances of spot and plage regions to be only weakly anticorrelated. Light curves can thus only give incomplete predictions of convective blueshift suppression. We must instead seek proxies that track the plage coverage on the visible stellar hemisphere directly. The chromospheric flux index R^' }_{HK} derived from the HARPS spectra performs poorly in this respect, possibly because of the differences in limb brightening/darkening in the chromosphere and photosphere. We also find that the activity-driven RV variations of the Sun are strongly correlated with its full-disc magnetic flux density, which may become a useful proxy for activity-related RV noise. [less ▲]

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See detailHigh spectral resolution monitoring of Nova V339 Delphini with TIGRE (Corrigendum)
De Gennaro Aquino, I.; Schröder, K.-P.; Mittag, M. et al

in Astronomy and Astrophysics (2016), 589

The tags in Table 2, indicating the positions of the most prominent spectral features in Figs. 2a and b, were not corrected during the revision process. We include here the corrected table. The lines ... [more ▼]

The tags in Table 2, indicating the positions of the most prominent spectral features in Figs. 2a and b, were not corrected during the revision process. We include here the corrected table. The lines observed and identified in the spectra and the respective phases remain unchanged. [less ▲]

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See detailSoil apparent conductivity measurements for planning and analysis of agricultural experiments: A case study from Western-Thailand
Rudolph, Sebastian; Wongleecharoen, Chalemchart; Lark, Murray et al

in Geoderma (2016), 267

In experimental trials, the success or failure of agricultural improvements is commonly evaluated on the agronomic response of crops, using proper experimental designs with sufficient statistical power ... [more ▼]

In experimental trials, the success or failure of agricultural improvements is commonly evaluated on the agronomic response of crops, using proper experimental designs with sufficient statistical power. Since fine-scale variability of the experimental site can reduce statistical power, efficiency gains in the experimental design can be achieved if this variation is known and used to design blocking, or some proxy variable is used as a covariate. Near-surface geophysical techniques such as electromagnetic induction (EMI), which describes subsurface properties non-invasively by measuring soil apparent conductivity (ECa), may be one source of this information. The motivation of our study was to investigate the effectiveness of EMI-derived ECa measurements for planning and analysis of agricultural experiments. ECa and plant height measurements (the response variable) were taken from an agroforestry experiment in Western Thailand, and their variability was quantified to simulate multiple realizations of ECa and the residuals of the response variable from treatment means. These were combined to produce simulated data from different experimental designs and treatment effects. The simulated data were then used to evaluate the statistical power by detecting three orthogonal contrasts among the treatments in the original experiment. We considered three experimental designs, a simple random design (SR), a complete randomized block design (CRB), and a complete randomized block design with spatially adjusted blocks on plot means of ECa (CRBECa). Using analysis of variance (ANOVA), the smallest effect sizes could be detected with the CRBECa design, which indicates that ECa measurements could be used in the planning phase of an experiment to achieve efficiencies by improved blocking. In contrast, analysis of covariance (ANCOVA) demonstrated that substantial power improvements could be gained when ECa was considered as a covariate in the analysis. We therefore recommend that ECa measurements should be used to characterize subsurface variability of experimental sites and to support the statistical analysis of agricultural experiments. [less ▲]

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See detailA map of the large day-night temperature gradient of a super-Earth exoplanet
Demory, Brice-Olivier; Gillon, Michaël ULg; de Wit, Julien et al

in Nature (2016), 532

Over the past decade, observations of giant exoplanets (Jupiter-size) have provided key insights into their atmospheres, but the properties of lower-mass exoplanets (sub-Neptune) remain largely ... [more ▼]

Over the past decade, observations of giant exoplanets (Jupiter-size) have provided key insights into their atmospheres, but the properties of lower-mass exoplanets (sub-Neptune) remain largely unconstrained because of the challenges of observing small planets. Numerous efforts to observe the spectra of super-Earths—exoplanets with masses of one to ten times that of Earth—have so far revealed only featureless spectra. Here we report a longitudinal thermal brightness map of the nearby transiting super-Earth 55 Cancri e (refs 4, 5) revealing highly asymmetric dayside thermal emission and a strong day-night temperature contrast. Dedicated space-based monitoring of the planet in the infrared revealed a modulation of the thermal flux as 55 Cancri e revolves around its star in a tidally locked configuration. These observations reveal a hot spot that is located 41 ± 12 degrees east of the substellar point (the point at which incident light from the star is perpendicular to the surface of the planet). From the orbital phase curve, we also constrain the nightside brightness temperature of the planet to 1,380 ± 400 kelvin and the temperature of the warmest hemisphere (centred on the hot spot) to be about 1,300 kelvin hotter (2,700 ± 270 kelvin) at a wavelength of 4.5 micrometres, which indicates inefficient heat redistribution from the dayside to the nightside. Our observations are consistent with either an optically thick atmosphere with heat recirculation confined to the planetary dayside, or a planet devoid of atmosphere with low-viscosity magma flows at the surface. [less ▲]

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See detailHerschel observations of the nebula M1-67 around the Wolf-Rayet star WR 124
Vamvatira-Nakou, C.; Hutsemekers, Damien ULg; Royer, P. et al

in Astronomy and Astrophysics (2016), 588

Infrared Herschel imaging and spectroscopic observations of the nebula M1-67 around the Wolf-Rayet star WR 124 have been obtained along with optical imaging observations. The infrared images reveal a ... [more ▼]

Infrared Herschel imaging and spectroscopic observations of the nebula M1-67 around the Wolf-Rayet star WR 124 have been obtained along with optical imaging observations. The infrared images reveal a clumpy dusty nebula that extends up to 1 pc. The comparison with the optical images shows that the ionized gas nebula coincides with the dust nebula, the dust and the gas being mixed together. A photodissociation region is revealed from the infrared spectroscopic analysis. The analysis of the infrared spectrum of the nebula, where forbidden emission lines of ionized elements were detected, showed that the nebula consists of mildly processed material with the calculated abundance number ratios being N/O = 1.0 ± 0.5 and C/O = 0.46 ± 0.27. Based on a radiative transfer model, the dust mass of the nebula was estimated to be 0.22 M[SUB]⊙[/SUB] with a population of large grains being necessary to reproduce the observations. The comparison of the mass-loss rate and the abundance ratios to theoretical models of stellar evolution led to the conclusion that the nebular ejection took place during a RSG/YSG evolutionary phase of a central star with an initial mass of 32 M[SUB]⊙[/SUB]. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Based in part on observations collected at the European Southern Observatory, La Silla, Chile. [less ▲]

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See detailLa polykystose rénale autosomique dominante : comment et pourquoi identifier les patients "rapidement progresseurs" vers l'insuffisance rénale terminale?
bodson, aurélie; MEUNIER, Paul ULg; Krzesinski, Jean-Marie ULg et al

in Revue Médicale de Liège (2016), 71(4), 184-192

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterised by the progressive development of multiple and bilateral cysts in kidneys and other organs. Most patients ... [more ▼]

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterised by the progressive development of multiple and bilateral cysts in kidneys and other organs. Most patients with ADPKD will develop, sooner or later, end-stage renal disease (ESRD). The morbidity and mortality associated with ESRD prompt physicians to identify early ADPKD patients considered as «rapid progressors», who have the greatest risk to rapidly develop ESRD. The rate of progression can be assessed by clinical - especially with the «predicting renal outcome in polycystic kidney disease score» (PROPKD-Score) -, biological (a decline of the glomerular filtration rate (GFR) of 4,4 - 5,9 ml/min/year and/or the doubling of serum creatinine within a 36-month period), or radiological criteria (total kidney volume (TKV) adjusted for the size > 600 cc/m and/or TKV annual growth rate > 5 %). Nowadays, there is no curative treatment for ADPKD. However, vasopressin-2 receptor antagonists, such as tolvaptan, appear to slow down the growth of renal cysts and the slope of GFR decline. The current management of ADPKD patients is mostly based on correcting the risk factors for progression, i.e. encouraging (over)-hydration, normalizing blood pressure, stimulating smoking cessation. [less ▲]

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See detailMirror-drawing skill in children with Specific Language Impairment: Improving generalization by incorporating variability in the practice session
Desmottes, Lise ULg; Maillart, Christelle ULg; Meulemans, Thierry ULg

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016)

This study aimed to investigate the procedural deficit hypothesis (PDH) in children with Specific Language Impairment (SLI) by using a mirror-drawing task, a sensorimotor adaptation paradigm that does not ... [more ▼]

This study aimed to investigate the procedural deficit hypothesis (PDH) in children with Specific Language Impairment (SLI) by using a mirror-drawing task, a sensorimotor adaptation paradigm that does not involve sequence learning and has never before been used in SLI. Thirty school-aged children with SLI matched to 30 control children had to trace several figures seen only in mirror-reversed view in two learning sessions separated by a one-week delay. Two practice conditions were compared: a constant condition in which children had to trace the same figure throughout the learning trials, and a variable one in which they had to trace different figures in each trial. Results revealed a similar learning pattern between SLI and TD children in both practice conditions, suggesting that initial learning for a nonsequential procedural task is preserved in SLI. However, children with SLI generalized the mirror-drawing skill in the same way as control children only if there was variability in the way the material was trained (variable practice). No significant schedule effects were observed in the control group. [less ▲]

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See detailLa multimorbidité : le médecin généraliste et les systèmes de santé mis au défi
Belche, Jean ULg; Crismer, André ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 55-57

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la ... [more ▼]

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la multimorbidité, chez un même patient. La manière dont sont structurés la production scientifique et les systèmes de santé, dont le paradigme dominant est la prise en charge de patients avec une seule morbidité, complique la prise en charge adéquate de cette population (1). Søndergaard a dès lors exploré les difficultés que rencontre le médecin généraliste (MG) face aux patients en situation de multimorbidité au travers d’ateliers auxquels ont participé près de 180 MG et chercheurs scandinaves. [less ▲]

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See detailMass Surveillance Technology: Trading Trojan Horses
Caponetti, Lia ULg

in Strategic Trade Review (2016), (Spring 2016), 53-71

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental ... [more ▼]

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental freedoms, and (b) surveillance technology export control, especially to third countries likely to use such technology to violate human rights. Following the Snowden Datagate scandal, many States undertook inquiries and adopted measures that, in some cases, were meant to regulate the use of mass surveillance technology. The paper will: a) assess and evaluate current regulations on mass surveillance technology and its place in democratic societies, including what is at stake in terms of technology, threats, reactions to threats, and geographic extension, b) the risks linked to the use of MST on the national level by questioning the validity of counter-terrorism measures as a justification for MST use c) analyze international trade control regimes and legislation to highlighting their inadequacy in the face of the threats posed by MST, and d) map the evolution of the EU dual-use trade control system towards a human security approach with regard to human rights protection, in order to assess the capability of the system to avoid the misuse of MST. [less ▲]

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See detailExposition "Magie et raison. Elisa von der Recke et l'affaire Cagliostro"
Leyh, Valérie ULg

in Culture, le Magazine Culturel de l'Université de Liège (2016)

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See detailIntensive enteral nutrition is ineffective for individuals with severe alcoholic hepatitis treated with corticosteroids.
Moreno, C; Deltenre, P; Senterre, C et al

in Gastroenterology (2016), 150

BACKGROUND & AIMS: Severe alcoholic hepatitis (AH) is a lifethreatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether ... [more ▼]

BACKGROUND & AIMS: Severe alcoholic hepatitis (AH) is a lifethreatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether the combination of corticosteroid and intensive enteral nutrition therapy is more effective than corticosteroid therapy alone in patients with severe AH. METHODS: We enrolled 136 heavy consumers of alcohol (age, 18–75 y) with recent onset of jaundice and biopsy-proven severe AH in our study, performed at 18 hospitals in Belgium and 2 in France, from February 2010 through February 2013. Subjects were assigned randomly (1:1) to groups that received either intensive enteral nutrition plus methylprednisolone or conventional nutrition plus methylprednisolone (controls). In the intensive enteral nutrition group, enteral nutrition was given via feeding tube for 14 days. The primary end point was patient survival for 6 months. RESULTS: In an intention-to-treat analysis, we found no significant difference between groups in 6-month cumulative mortality: 44.4% of patients died in the intensive enteral nutrition group (95% confidence interval [CI], 32.2%–55.9%) and 52.1% of controls died (95% CI, 39.4%– 63.4%) (P ¼ .406). The enteral feeding tube was withdrawn prematurely from 48.5% of patients, and serious adverse events considered to be related to enteral nutrition occurred in 5 patients. Regardless of group, a greater proportion of patients with a daily calorie intake less than 21.5 kcal/kg/day died (65.8%; 95% CI, 48.8–78.4) than patients with a higher intake of calories (33.1%; 95% CI, 23.1%–43.4%) (P < .001). CONCLUSIONS: In a randomized trial of patients with severe AH treated with corticosteroids, we found that intensive enteral nutrition was difficult to implement and did not increase survival. However, low daily energy intake was associated with greater mortality, so adequate nutritional intake should be a main goal for treatment. [less ▲]

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See detailMicrowave-assisted extraction of pectin from unutilized pumpkin biomass
Košťálová, Zuzana; Aguedo, Mario ULg; Hromádkováa, Zdenka

in Chemical Engineering and Processing: Process Intensification (2016), 102

Microwave-assisted extraction was employed to extract polysaccharides from pumpkin biomass and compared to the usual extraction by conventional heating. The effect of microwave heating time, liquid/solid ... [more ▼]

Microwave-assisted extraction was employed to extract polysaccharides from pumpkin biomass and compared to the usual extraction by conventional heating. The effect of microwave heating time, liquid/solid (L/S) ratio and extraction temperature on the yield and molecular mass of extracted pectin from the seeded oil pumpkin biomass was investigated. Heating times ranged from 2 to 10 min, L/S ratio from 30/1 to 50/1 and temperature from 80 to 120 °C. The response surface methodology was used to optimize the effects of processing parameters to isolate pectin with medium molecular weight and with the highest yield. The retained conditions were as follows: liquid/solid ratio 50/1, microwave heating time of 10 min and a temperature of 102.2 °C. Among the studied factors, the liquid/solid ratio had the greatest influence on yield and molecular mass, respectively. Application of microwave heating in the extraction of pumpkin biomass gave a pectin with medium Mw and dramatically reduced extraction time in comparison to traditional hot acid extraction. Microwave is an excellent tool for extraction and modification of polysaccharides in one step. [less ▲]

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See detailPrevalence and determinants of vitamin D deficiency in healthy French adults: the VARIETE study
Souberbielle; Massart, Catherine; Brailly-Tabard, Sylvie et al

in Endocrine (2016)

The U.S. Institute of Medicine considers that a serum 25-hydroxyvitamin D (25OHD) concentration >20 ng/mL corresponds to optimal vitamin D status in the general population. Old studies of vitamin D status ... [more ▼]

The U.S. Institute of Medicine considers that a serum 25-hydroxyvitamin D (25OHD) concentration >20 ng/mL corresponds to optimal vitamin D status in the general population. Old studies of vitamin D status in the French general population have demonstrated high prevalence of insufficiency. We measured serum 25OHD, 1,25(OH)2D, PTH, calcium, phosphorus, and creatinine levels in 892 French Caucasian healthy subjects (463 men, 429 women) aged from 18 to 89 years. The 25OHD concentration was similar in men (24.1 ± 8.2 ng/mL) and women (23.4 ± 8.0 ng/mL). 25OHD concentrations of <10, <12, <20, and <30 ng/mL were found in respectively 6.3, 9.9, 34.6, and 80.3 % of subjects. Residence in northern France (odds ratio [OR] 1.91), blood sampling between January and March (OR 7.74), BMI ≥24 kg/m2 (OR 1.81), and age 60 years or more (OR 1.99) were significant determinants of hypovitaminosis D (25OHD <20 ng/mL). The serum 25OHD level correlated positively with 1,25(OH)2D and negatively with PTH. 25OHD values below 20 ng/mL were associated with lower 1,25(OH)2D levels, and 25OHD values below 27 ng/mL were associated with higher PTH levels. Many French healthy adults have a 25OHD concentration <20 ng/mL, especially during winter months. Actions to improve the vitamin D status of the French general population are urgently needed. [less ▲]

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See detailAdaptation transculturelle et validation des questionnaires VISA-P et VISA-A en français
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Science & Sports (2016), 31(2), 65-72

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A ... [more ▼]

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A), English questionnaires developed respectively to assess the severity of patellar and calcaneal tendinopathies. The purpose of our study was to validate a French version of these questionnaires. Materials and methods The French translation and intercultural adaptation of the VISA-P and the VISA-A are made according to international recommendations. For these adaptations, 92 (VISA-P) and 116 (VISA-A) subjects were recruited and divided into 3 groups (pathological, asymptotic and sporting risk), in order to test these psychometric properties. All these subjects also had to answer to the MOS SF-36 for the validity of construct. Results The mean VISA-PF scores were 99 for the healthy people, 53 for patients with patellar tendinopathy and 86 for the athletes. The VISA-PF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.9 (Cronbach's alpha). The VISA-PF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. The mean VISA-AF scores were 99 in the healthy group, 59 in the pathological group, and 94 in the group of athletes. The VISA-AF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.92 (Cronbach's alpha). The VISA-AF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. No floor and ceiling effects were detected during the evaluation of the two questionnaires. Conclusion The French versions of the VISA-P and VISA-A questionnaires are therefore French comprehensible adaptation, reliable and adapted to French-speaking patients suffering from patellar or calcaneal tendinopathies. [less ▲]

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See detailExercise-triggered chest pain as an isolated symptom of myocarditis in children
Tshimanga, Prisca; Daron, Benoît; FARHAT, Nesrine ULg et al

in Clinics and Practice (2016), 6:843

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See detailLes juristes belges et la réhabilitation du droit à la guerre du Traité de Versailles au ‘Mouvement de Monaco’ de 1933-1938
Genin, Vincent ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), 2016/1(Soixante et unième année), 155-188

Depuis la Charte des Nations Unies de 1945, l'interdiction du "recours à la force" est consacré comme règle de droit international applicable aux Etats. Toutefois, durant l'entre-deux-guerres, surtout de ... [more ▼]

Depuis la Charte des Nations Unies de 1945, l'interdiction du "recours à la force" est consacré comme règle de droit international applicable aux Etats. Toutefois, durant l'entre-deux-guerres, surtout de 1933 à 1938, la réhabilitation d'un droit à la guerre, jugée plus pragmatique par certains juristes que sa mise "hors-la-loi" par le Pacte Briand-Kellogg de 1929, connaît quelque succès. En réaction à ce qu'ils estiment être les "failles" des Pactes de la SDN et de Paris, médecins-militaires et juristes, surtout belges et français, en vue d'"humaniser la guerre" pour, selon eux, la rendre plus rare, forment un éphémère courant, oublié et devenu anachronique : le "Mouvement de Monaco". Tel est l'objet de notre étude. [less ▲]

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See detailTaller trees, denser stands and greater biomass in semi-deciduous than in evergreen lowland central African forests
Fayolle, Adeline ULg; Loubota Panzou, Grâce Jopaul ULg; Drouet, Thomas et al

in Forest Ecology & Management (2016), 374

Accurate height-diameter allometry is crucial for the estimation of forest biomass and carbon stocks. Tree height measurements over a large range of diameters and species are urgently needed in the ... [more ▼]

Accurate height-diameter allometry is crucial for the estimation of forest biomass and carbon stocks. Tree height measurements over a large range of diameters and species are urgently needed in the tropics, specifically in central Africa, for the development of locally derived height-diameter allometric equations and the conversion of forest inventory data into biomass estimates, and for the validation of remotely sensed canopy height that mostly rely on a few specific field sites. In this study, we aimed to identify the variation in height-diameter allometry of tropical trees between forest types and among species in central Africa, and we examined the consequences for biomass estimation. Height and diameter were measured for a total of 521 trees over a large range of diameters in two forest types in southern Cameroon, 10–240 cm in the evergreen forest and 11–182 cm in the semi-deciduous forest. A total of ten allometric models including asymptotic and non-asymptotic models were fitted to the heightdiameter data. Measured tree diameters, grouped into 10 cm wide diameter classes up to 150, from commercial forest inventory data (0.5 ha plots, n = 2101 and n = 5152, respectively in the evergreen and in the semi-deciduous forests) were converted into biomass estimates using general allometric models with and without including our site-specific height-diameter allometry. Though debated in the literature, our results supported a saturation of tree height with tree diameter both at site and species level, with asymptotic models better depicting the height-diameter allometry. Height-diameter allometry significantly differed between forest types and these local height-diameter equations also differed from published equations. For a given diameter, trees tended to be taller in the semi-deciduous forest than in the evergreen forest, as already reported between moist and wet forests in pantropical studies. Similar trends were reported within species for the three species shared by both forest types, suggesting an environmental control of tree allometry. Because of the low performance of the bioclimatic stress variable to predict tree height and of the slight soil differences between the two forest types, the environmental determinants of height-diameter allometry remain to be explored. In addition to tree allometry variation, structural differences (basal area and density) were also identified between the two forest types using commercial forest inventory data at genus level, and both allometry and forest structure (taller trees and denser stands) contributed to the greater biomass per hectare of the semi-deciduous forest. [less ▲]

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See detailSelenium in Cattle: A Review
Mehdi, Youcef ULg; Dufrasne, Isabelle ULg

in Molecules (2016), 21(4), 545

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include ... [more ▼]

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include the participation in the antioxidant defense the cattle farms. The nutritional requirements of Se in cattle are estimated at 100 μg/kg DM (dry matter) for beef cattle and at 300 μg/kg DM for dairy cows. The rations high in fermentable carbohydrates, nitrates, sulfates, calcium or hydrogen cyanide negatively influence the organism’s use of the selenium contained in the diet. The Se supplementation may reduce the incidence of metritis and ovarian cysts during the postpartum period. The increase in fertility when adding Se is attributed to the reduction of the embryonic death during the first month of gestation. A use of organic Se in feed would provide a better transfer of Se in calves relative to mineral Se supplementation. The addition of Se yeasts in the foodstuffs of cows significantly increases the Se content and the percentage of polyunsaturated fatty acids (PUFA) in milk compared to the addition of sodium selenite. The enzyme 5-iodothyronine deiodinase is a seleno-dependent selenoprotein. It is one of the last proteins to be affected in the event of Se deficiency. This delay in response could explain the fact that several studies did not show the effect of Se supplementation on growth and weight gain of calves. Enrichment of Se in the diet did not significantly affect the slaughter weight and carcass yield of bulls. The impact and results of Se supplementation in cattle depend on physiological stage, Se status of animals, type and content of Se and types of Se administration. Further studies in Se supplementation should investigate the speciation of Se in food and yeasts, as well as understanding their metabolism and absorption. This constitute a path to exploit in order to explain certain different effects of Se. [less ▲]

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See detailFibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women
Runhaar, Jos; Sanchez, Christelle ULg; Taralla, Sébastien et al

in Osteoarthritis Cartilage (2016), 24(4), 672-678

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg ... [more ▼]

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 +/- 3.2 years and mean BMI of 31.7 +/- 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >/=1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade >/=2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic pain at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. [less ▲]

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See detailQuelle est l’efficacité de soins collaboratifs et intégrés pour des patients en situation de multimorbidité physique et mentale en ambulatoire ?
Belche, Jean ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 58-63

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la ... [more ▼]

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la multimorbidité, définie comme la présence d’au moins 2 maladies chroniques), augmente substantiellement avec l’âge (≥ 65 ans) mais qu’en nombre absolu de patients, elle touche plus de patients plus jeunes (plus de 50% en dessous de 65 ans). Près d’un tiers de ces patients multimorbides souffre de problèmes de santé mentale (dépression, troubles psychotiques, etc.), dont la gravité augmente avec le nombre de comorbidités et le statut socio-économique. L’étude analysée ici fait l’hypothèse d’un bénéfice d’un modèle de soins collaboratif et intégré en première ligne de soins sur la dépression et la gestion de la maladie chronique par le patient, tout en veillant à sélectionner une population représentative du constat démographique actuel de multimorbidité. [less ▲]

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See detailFragmented Territories: Incomplete Enclosures and Agrarian Change on the Agricultural Frontier of Samlaut District, North-West Cambodia
Diepart, Jean-Christophe ULg; Sem, Thol

in Journal of Agrarian Change (2016)

In Cambodia, the interactions between large-scale land investment and land titling gathered particular momentum in 2012–13, when the government initiated an unprecedented upland land titling programme in ... [more ▼]

In Cambodia, the interactions between large-scale land investment and land titling gathered particular momentum in 2012–13, when the government initiated an unprecedented upland land titling programme in an attempt to address land tenure insecurity where large-scale land investment overlaps with land appropriated by peasants. This paper is based on a spatially explicit ethnography of land rights conducted in the Samlaut district of north-west Cambodia – a former Khmer Rouge resistance stronghold – in a context where the enclosures are both incomplete and entangled with post-war, socially embedded land tenure systems. We discuss how this new pattern of fragmentation affects the prevailing dynamics of agrarian change. We argue that it has introduced new forms of exclusion and a generalized perception of land tenure uncertainty that is managed by peasants through the actualization of hybrid land tenure arrangements borrowing from state rules and local consensus. In contrast with common expectations about land formalization, the process reinforces the patterns of social differentiation initiated by land rent capture practices of early migrants and pushes more vulnerable peasants into seeking wage labour and resorting to job migration. [less ▲]

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See detailUne école belge de l’anticipation ?
Stienon, Valérie ULg

in Textyles : Revue des Lettres Belges de Langue Française (2016), 48

Prolifique dans les littératures de l'imaginaire, la Belgique présente pourtant une inconnue s'agissant du récit d'anticipation. Il suffit pour en prendre la mesure de comparer les situations respectives ... [more ▼]

Prolifique dans les littératures de l'imaginaire, la Belgique présente pourtant une inconnue s'agissant du récit d'anticipation. Il suffit pour en prendre la mesure de comparer les situations respectives de ces deux « genres » réputés voisins que sont la science-fiction et le fantastique. Celui-ci a été érigé en emblème des terres du syncrétisme et de l'étrange, tandis que celle-là a souffert d'expressions isolées et de dénis compliquant sa réception. La situation de l'anticipation est plus complexe encore : souvent rattachée à la science-fiction, dont elle constituerait une étape archaïque ou protohistorique, elle ne se confond pas tout à fait avec elle. Ne se définissant pas exclusivement par les thématiques scientifiques ou extraterrestres, ni même par la seule dimension futuriste, l'anticipation se donne pour objet une exploration imaginaire des mondes possibles. Cette exploration s'est manifestée plus d'une fois avec succès dans l'histoire des lettres belges, des fictions de Rosny aîné (Les Xipéhuz, La Force mystérieuse, Les Navigateurs de l'infini) aux mondes parallèles créés par François Schuiten et Benoît Peeters, des aventures spatiales de Bob Morane aux technosciences de Gilbert Hottois. Mais quel dénominateur commun peut-on trouver à ce corpus disparate ? Et comment faire l'archéologie d'une production qui a trouvé des expressions variées et originales malgré une généricité hybride et l'absence de représentant majeur ? [less ▲]

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See detailPrognostic value of baseline total metabolic tumor volume (TMTV0) measured on FDG-PET/CT in patients with peripheral T-cell lymphoma (PTCL)†
Cottereau, A.S.; Becker, S.; Broussais, F. et al

in Annals of Oncology (2016), 27

Background: Most peripheral T-cell lymphoma (PTCL) patients have a poor outcome and the identification of prognostic factors at diagnosis is needed. Patients and methods: The prognostic impact of total ... [more ▼]

Background: Most peripheral T-cell lymphoma (PTCL) patients have a poor outcome and the identification of prognostic factors at diagnosis is needed. Patients and methods: The prognostic impact of total metabolic tumor volume (TMTV0), measured on baseline [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography, was evaluated in a retrospective study including 108 PTCL patients (27 PTCL not otherwise specified, 43 angioimmunoblastic T-cell lymphomas and 38 anaplastic large-cell lymphomas). All received anthracycline-based chemotherapy. TMTV0 was computed with the 41% maximum standardized uptake value threshold method and an optimal cut-off point for binary outcomes was determined and compared with others prognostic factors. Results: With a median follow-up of 23 months, 2-year progression-free survival (PFS) was 49% and 2-year overall survival (OS) was 67%. High TMTV0 was significantly associated with a worse prognosis. At 2 years, PFS was 26% in patients with a high TMTV0 (>230 cm3, n = 53) versus 71% for those with a low TMTV0, [P < 0.0001, hazard ratio (HR) = 4], whereas OS was 50% versus 80%, respectively, (P = 0.0005, HR = 3.1). In multivariate analysis, TMTV0 was the only significant independent parameter for both PFS and OS. TMTV0, combined with PIT, discriminated even better than TMTV0 alone, patients with an adverse outcome (TMTV0 >230 cm3 and PIT >1, n = 33,) from those with good prognosis (TMTV0 ≤230 cm3 and PIT ≤1, n = 40): 19% versus 73% 2-year PFS (P < 0.0001) and 43% versus 81% 2-year OS, respectively (P = 0.0002). Thirty-one patients (other TMTV0–PIT combinations) had an intermediate outcome, 50% 2-year PFS and 68% 2-year OS. Conclusion: TMTV0 appears as an independent predictor of PTCL outcome. Combined with PIT, it could identify different risk categories at diagnosis and warrants further validation as a prognostic marker. [less ▲]

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See detailPeanut-allergic patients in the MIRABEL survey: characteristics, allergists' dietary advice and lessons from real life
Deschildre, A; Elegbédé, CF; Just, J et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2016), 46(4), 610-20

Background The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to ... [more ▼]

Background The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to study the presence of peanut traces in pre-packed foods with/without precautionary allergen labelling (PAL), and to combine these data to quantify allergic risk and produce a cost/benefit analysis. This paper reports a real-life observatory of 785 patients (< 16y: 86%): medical characteristics, eliciting doses (ED) in real life and in oral food challenges (OFC), factors associated with severe reactions, allergist dietary advice and patients’ anxiety regarding their allergy. Methods Age and symptoms at diagnosis, route of exposure, comorbidities, allergy tests, ED (OFC/real life; mg peanut protein), dietary advice about PAL, and anxiety score were recorded. Results Median age was 3 years; 85% were declared allergic. Severe/potentially severe reactions were reported in 30% of the allergic patients: serious systemic reaction (15%), laryngeal angioedema (8%), shock (4%) and acute asthma (3%); 66% had atopic dermatitis, 58% asthma. Median ara h 2 sIgE level was 11.5 kUA/L. Of the 278 OFCs, 225 were positive (median ED: 67.3 mg). Real-life ED was < 100 mg in 44.3%. Severe reactions were significantly more frequent in teenagers and adults (P = 0.004), asthmatic patients (P = 0.033), and patients who reacted to inhalation (P < 0.001). No significant association was found for OFC ED or ara h 2 sIgE. Factors associated with strict avoidance advice including PAL were OFC ED < 100 mg (P < 0.001), but not severe reaction history (P = 0.051) or asthma (P = 0.34). Anxiety was significantly associated with strict avoidance (P < 0.001). Conclusion and clinical relevance Severe/potentially severe reactions, allergic comorbidities, and low EDs in real life are frequent in peanut-allergic patients. Asthma, teenage/ adulthood and reaction to inhalation are associated with severe symptoms. PAL and criteria guiding dietary advice need to be improved. [less ▲]

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See detailInfluence of a liquid nutritional supplement on water intake in experimental Beagle dogs
Rotat, Christelle; Lhoest, Estelle; Rauw, Anaelle ULg et al

in Open Journal of Veterinary Medicine (2016), 6

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over ... [more ▼]

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over design in 8 experimental healthy Beagle dogs (4 males and 4 females, aged 9.3 years). The supplement (87 percent water, 2.7 percent protein, 2.6 percent fat, 0.4 percent crude fiber) was added to water and tested at 2 incorporation rates (50 or 70 ml/day/dog—D50 or D70) versus the control placebo (CO-water only). The dogs were kept in a controlled environment; water intakes and urine output were measured. Individual water intakes were characterised by large variations. Mean water intake increased significantly by 28 percent in dogs receiving the liquid nutritional supplement, in both genders, irrespectively of the dosage. Urine output was also increased, by 55 percent. Faeces scores remained unchanged. It was concluded that the liquid supplement increased water intake and urine output in a safe way, without increasing dramatically the daily dietary sodium chloride intake. The recommended dosage of the manufacturer—50 ml/day for dogs weighing 10 - 20 kg BW is efficient. Increasing the dosage had no advantage, nor adverse effects. Increased water intake and urine output is of interest for dogs suffering from urolithiasis. [less ▲]

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See detailEvidence for the alignment of quasar radio polarizations with large quasar group axes
Pelgrims, Vincent ULg; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (2016), 590

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on ... [more ▼]

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on observations made at optical wavelengths for two large quasar groups at redshift ~1.3. The correlation suggests that the spin axes of quasars preferentially align with their surrounding large-scale structure that is assumed to be traced by the LQGs. Here, we consider a large sample of LQGs built from the Sloan Digital Sky Survey DR7 quasar catalogue in the redshift range 1.0 -􀀀 1.8. For quasars embedded in this sample, we collected radio polarization measurements with the goal to study possible correlations between quasar polarization vectors and the major axis of their host LQGs. Assuming the radio polarization vector is perpendicular to the quasar spin axis, we found that the quasar spin axis is preferentially parallel to the LQG major axis inside LQGs that have at least 20 members. This result independently supports the observations at optical wavelengths. We additionally found that when the richness of an LQG decreases, the quasar spin axis becomes preferentially perpendicular to the LQG major axis and that no correlation is detected for quasar groups with fewer than 10 members. [less ▲]

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See detailUn cas d'hypercalcémie secondaire à une hyperparathyrïdie primaire canine traité chirurgicalement.
CLABOTS, Maëlle; Darnis, Elodie ULg; Claeys, Stéphanie ULg

in Monde Vétérinaire (Le) (2016), 159

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See detailLe travailleur à temps partiel et la présomption de travail à temps plein
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (14), 654-655

L'article oppose la présomption de travail à temps plein énoncée par l’article 171 de la loi-programme du 22 décembre 1989, qui est étrangère aux relations entre l’employeur et le travailleur, à la ... [more ▼]

L'article oppose la présomption de travail à temps plein énoncée par l’article 171 de la loi-programme du 22 décembre 1989, qui est étrangère aux relations entre l’employeur et le travailleur, à la sanction inscrite dans l'article 11bis de la loi relative aux contrats de travail. Le travailleur ne peut alléguer la présomption pour obtenir le paiement d’arriérés de salaire ou d’une indemnité compensatoire de préavis calculés sur la base d’une rémunération à temps plein. [less ▲]

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See detailHistoire de la philosophie et pratique philosophique : usages fertiles
Herla, Anne ULg

in Diotime, Revue internationale de didactique de la philosophie (2016), 68

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See detailLagrangian and arbitrary Lagrangian Eulerian simulations of complex roll-forming processes
Crutzen, Yanick ULg; Boman, Romain ULg; Papeleux, Luc ULg et al

in Comptes Rendus Mécanique (2016), 344(4-5), 251-266

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ... [more ▼]

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ALE formalism can compute the hopefully stationary state for the entire mill length with definitely effortless set-up tasks thanks to a nearly-stationary mesh. In this paper, advantages of ALE and Lagrangian formalisms are extensively discussed for simulating such continuous-type processes. Through a highly complex industrial application, the ease of use of ALE modelling is illustrated with the in-house code METAFOR. ALE and Lagrangian results are in good agreement with each other. [less ▲]

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See detailExperimental Tests and Numerical Modelling on Slender Steel Columns at High Temperatures
Franssen, Jean-Marc ULg; Zhao, Bin; Gernay, Thomas ULg

in Journal of Structural Fire Engineering (2016), 7(1), 30-40

Purpose The purpose of this paper is to gain from experimental tests an insight into the failure mode of slender steel columns subjected to fire. The tests will also be used to validate a numerical model ... [more ▼]

Purpose The purpose of this paper is to gain from experimental tests an insight into the failure mode of slender steel columns subjected to fire. The tests will also be used to validate a numerical model. Design/methodology/approach A series of experimental fire tests were conducted on eight full-scale steel columns made of slender I-shaped Class 4 sections. Six columns were made of welded sections (some prismatic and some tapered members), and two columns were made of hot rolled sections. The nominal length of the columns was 2.7 meters with the whole length being heated. The load was applied at ambient temperature after which the temperature was increased under constant load. The load was applied concentrically on some tests and with an eccentricity in other tests. Heating was applied by electrical resistances enclosed in ceramic pads. Numerical simulations were performed with the software SAFIR® using shell elements. Findings The tests have allowed determining the appropriate method of application of the electrical heating system for obtaining a uniform temperature distribution in the members. Failure of the columns during the tests occurred by combination of local and global buckling. The numerical model reproduced correctly the failure modes as well as the critical temperatures. Originality/value The numerical model that has been validated has been used in subsequent parametric analyses performed to derive design equations to be used in practice. This series of test results can be used by the scientific community to validate their own numerical or analytical models for the fire resistance of slender steel columns. [less ▲]

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See detailLes kystes ovariens chez le cobaye
Gillet, Aline; Deflers, Hélène ULg; Marlier, Didier ULg

in Revue de Médecine Vétérinaire (2016), 167(3-4), 51-58

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See detailClinically Relevant Optical Properties of Bifocal, Trifocal, and Extended Depth of Focus Intraocular Lenses
Gatinel, Damien; Loicq, Jerôme ULg

in Journal of Refractive Surgery (2016), 32(4), 273-280

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ... [more ▼]

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ZMB00 (bifocal; Abbott Medical Optics, Abbott Park, IL), TECNIS Symfony ZXR00 (extended depth of focus; Abbott Medical Optics), and FineVision GFree hydrophobic (trifocal; PhysIOL, Liège, Belgium). Their surface topography was analyzed by optical microscopy. Modulation transfer function (MTF) and spherical aberrations were determined on optical bench for variable pupil apertures and with two cornea models (0 μm and +0.28 μm). United States Air Force target imaging was analyzed for different focal points (near, intermediate, and far). Point spread function (PSF) and halos were quantified and compared. RESULTS: The three lenses presented step-like optic topography. For a pupil size of 3 mm or greater, clearly distinctive MTF peaks were observed for all lenses: two peaks for the extended depth of focus and bifocal lenses with +1.75 and +4.00 diopters (D) addition, respectively, and three peaks for the trifocal lens with +1.75 and +3.50 addition for intermediate and near vision, respectively. The extended depth of focus and bifocal lens had slightly higher MTF at best focus with the +0.28 μm cornea model than with the 0 μm model, whereas the trifocal lens was likely to be more independent of the corneal spherical aberrations.CONCLUSIONS: It appears that the three lenses rely on light diffraction for their optical performance, presenting halos with comparable intensities. For small pupil apertures (< 3 mm), the MTF peaks for the far and intermediate focal distances of the trifocal and extended depth of focus lenses overlap, but the trifocal lens presented an additional MTF peak for the near focal points. [less ▲]

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See detailRELMs in the Realm of Helminths
Horsnell, William G. C.; Dewals, Benjamin G ULg

in Trends in parasitology (2016)

Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMalpha over RELMbeta in host immunity to Nippostrongylus ... [more ▼]

Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMalpha over RELMbeta in host immunity to Nippostrongylus brasiliensis using a double knockout system. The study highlighted how important and yet divergent the contributions of these proteins are in the control of helminth infections. [less ▲]

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See detailBrentano or Husserl? Intentionality, Consciousness, and Self-consciousness in Contemporary Phenomenology of Mind
Boccaccini, Federico ULg

in Archivio di Filosofia (2016), LXXXIII(3), 189-202

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See detailVIGNETTE DIAGNOSTIQUE DE L'ETUDIANT. LogBook Numérique : Un carnet de bord réflexif comme outil d'apprentissage en contexte de stage.
Scantamburlo, Gabrielle ULg; Vierset, Viviane; Bonnet, Pierre ULg et al

in Revue Médicale de Liège (2016), 71(4), 210-215

Un LogBook (ou journal de bord) est un outil d’apprentissage et d’accompagnement où sont répertoriées des situations cliniques vécues lors d’un stage. Il joue un rôle essentiel dans la maîtrise des ... [more ▼]

Un LogBook (ou journal de bord) est un outil d’apprentissage et d’accompagnement où sont répertoriées des situations cliniques vécues lors d’un stage. Il joue un rôle essentiel dans la maîtrise des compétences cliniques. Au Centre Hospitalier Universitaire de Liège, nous avons développé un LogBook numérique pour renforcer le guidage des étudiants et favoriser une réflexion vers l’autonomisation. Il apporte des repères utiles aux enseignants cliniciens et aux étudiants. Il est aussi utilisé comme outil de co-évaluation. Ce LogBook a été conçu pour le stage en psychiatrie. Cependant, sa particularité est de pouvoir être adapté à tous les contextes de stage, dans toutes les disciplines, en vue de favoriser une harmonisation cohérente du parcours clinique de l’étudiant, en lien avec les impératifs du cursus donnés par l’Europe. [less ▲]

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See detailAIRWAYS-ICPs (European Innovation Partnership on Active and Healthy Ageing) from concept to implementation.
Bousquet, Jean; Barbara, Cristina; Bateman, Eric et al

in European Respiratory Journal (2016), 47(4), 1028-33

Chronic respiratory diseases (CRDs) are major non-communicable diseases (NCDs) that induce a significant burden. Asthma often occurs along the life cycle from early childhood, affecting 30 million ... [more ▼]

Chronic respiratory diseases (CRDs) are major non-communicable diseases (NCDs) that induce a significant burden. Asthma often occurs along the life cycle from early childhood, affecting 30 million children and adults under 45 years of age in Europe. Chronic obstructive pulmonary disease (COPD) has an estimated annual death rate of over 3 million people globally. The annual direct and indirect costs in the 28 European Union (EU) countries due to COPD or asthma are estimated at 48 billion euros and 34 billion euros respectively. Rhinitis occurs in over 100 million people in Europe, and indirect costs are enormous. Asthma is a common risk factor for COPD. CRDs impact ageing and should be prevented, recognised and managed across the life cycle to promote active and healthy ageing (AHA). There is an urgent need to act globally. European Innovation Partnerships (EIPs) aim to enhance EU competitiveness and tackle societal challenges through research and innovation. To tackle the potential of ageing in the EU, the European Commission, within its Innovation Union policy, launched the EIP on AHA (between the Directorate General for Health and Food Safety (DG Santé) and Directorate General for Communications Networks, Content and Technology (DG CONNECT)). The B3 Action Plan promotes integrated care models for chronic diseases, including the use of remote monitoring. The initiative AIRWAYS-ICPs (integrated care pathways for airway diseases) has been approved by the EIP on AHA as the model of chronic diseases of the B3 Action Plan. It is a Research Demonstration Project of the World Health Organization's Global Alliance against Chronic Respiratory Diseases (GARD). AIRWAYS-ICPs was initiated in 2013 by the WHO Collaborating Centre of Montpellier and the EIP on AHA Reference Site MACVIA-LR (Contre les MAladies Chroniques Pour un Vieillissement Actif en Languedoc-Roussillon, France) led by the Région Languedoc-Roussillon (France). [less ▲]

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See detailLe hate speech et la liberté d'expression dans la jurisprudence américaine sous l'angle de la philosophie du langage
Thirion, Nicolas ULg; Vandenbulke, Antoine ULg

in Auteurs & Media (2016)

Analysis of landmark US Supreme Court cases on hate speech evaluated in terms of philosophy of language, particularly through the works of J.L. Austin and Judith Butler.

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See detailContrasted accumulation patterns of persistent organic pollutants and mercury in sympatric tropical dolphins from the south-western Indian Ocean
Dirtu, Alin; Malavannan, Govindan; Das, Krishna ULg et al

in Environmental Research (2016), 146

Due to their high trophic position and long life span, small cetaceans are considered as suitable bioindicators to monitor the presence of contaminants in marine ecosystems. Here, we document the ... [more ▼]

Due to their high trophic position and long life span, small cetaceans are considered as suitable bioindicators to monitor the presence of contaminants in marine ecosystems. Here, we document the contamination with persistent organic pollutants (POPs) and total mercury (T-Hg) of spinner (Stenella longirostris, n=21) and Indo-Pacific bottlenose dolphins (Tursiops aduncus, n=32) sampled from the coastal waters of La Réunion (south-western Indian Ocean). In addition, seven co-occurring teleost fish species were sampled and analyzed as well. Blubber samples from living dolphins and muscle from teleosts were analyzed for polychlorinated biphenyls (PCBs), DDT and metabolites (DDTs), chlordanes (CHLs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), and polybrominated diphenyl ethers (PBDEs). Methoxylated PBDEs (MeO-PBDEs), reported as having a natural origin, were also analyzed. T-Hg levels were measured in blubber and skin biopsies of the two living dolphin species. δ13C and δ15N values were determined in skin of the dolphins and in the muscle of teleosts. For PCBs, HCHs and T-Hg, concentrations were significantly higher in T. aduncus than in S. longirostris. For other POP levels, intra-species variability was high. MeO-PBDEs were the dominant compounds (55% of the total POPs) in S. longirostris, while PCBs dominated (50% contribution) in T. aduncus. Other contaminants showed similar profiles between the two species. Given the different patterns of POPs and T-Hg contamination and the stable isotope composition observed among analyzed teleosts, dietary and foraging habitat preferences possibly explain the contrasted contaminant profiles observed in the two dolphin species. Levels of each class of contaminants were significantly higher in males than females. Despite their spatial and temporal overlap in the waters of La Réunion, S. longirostris and T. aduncus are differently exposed to contaminant accumulation. [less ▲]

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See detailAnticipation et mondes parallèles. Entretien avec Benoît Peeters et François Schuiten
Stienon, Valérie ULg

in Textyles : Revue des Lettres Belges de Langue Française (2016), 48

Benoît Peeters et François Schuiten ont aimablement accepté l’invitation de l’entretien, qui a eu lieu le 12 janvier 2015 au café Le Wilson en face du Palais de Chaillot où se tient l’exposition Revoir ... [more ▼]

Benoît Peeters et François Schuiten ont aimablement accepté l’invitation de l’entretien, qui a eu lieu le 12 janvier 2015 au café Le Wilson en face du Palais de Chaillot où se tient l’exposition Revoir Paris. [less ▲]

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See detailHistopathological effects of Aspergillus clavatus (Ascomycota: Trichocomaceae) on larvae of the southern house mosquito, Culex quinquefasciatus (Diptera: Culicidae)
Bawin, Thomas ULg; Seye, Fawrou; Boukraa, Slimane ULg et al

in Fungal Biology (2016), 120(4), 489-499

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal ... [more ▼]

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal activity was investigated regarding histological damages on Culex quinquefasciatus larvae exposed to A. clavatus spores. Multiple concentration assays using spore suspensions (0.5 x 10^8 to 2.5 x 10^8 spores/ml) revealed 17.0% to 74.3% corrected mortalities after 48 h exposure. Heat-deactivated spores induced a lower mortality compared to non-heated spores suggesting that insecticidal effects are actively exerted. Spore-treated and untreated larvae were prepared for light microscopy as well as for scanning and transmission electron microscopy. Spores failed to adhere to the external body surface (except the mouth parts) of these aquatic immature stages but progressively filled the digestive tract where their metabolism seemed to activate. In parallel, the internal tissues of the larvae, i.e. the midgut wall, the skeletal muscles, and the cuticle-secreting epidermis, were progressively destroyed between 8 and 24 h of exposure. These observations suggest that toxins secreted by active germinating spores of A. clavatus in the digestive tract altered the larval tissues, leading to their necrosis and causing larval death. Fungal proliferation and sporulation then occurred during a saprophytic phase. A. clavatus enzymes or toxins responsible for these pathogenic effects need to be identified in further studies before any use of this fungus in mosquito control. [less ▲]

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See detailInsertion professionnelle et parcours enseignants : mise en perspective
Simons, Germain ULg

in Didactiques en Pratique (2016), (2),

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See detailLocalized Piezoelectric Alveolar Decortication for Orthodontic Treatment in Adults: A Randomized Controlled Trial
CHARAVET, Carole ULg; LECLOUX, Geoffrey ULg; BRUWIER, Annick ULg et al

in Journal of Dental Research (2016)

AIMS : This randomized controlled trial aimed to evaluate the benefits and clinical outcomes of piezocision, which is a minimally invasive approach to corticotomy that is used in orthodontic treatments ... [more ▼]

AIMS : This randomized controlled trial aimed to evaluate the benefits and clinical outcomes of piezocision, which is a minimally invasive approach to corticotomy that is used in orthodontic treatments. MATERIALS AND METHODS : Twenty-four adult patients presenting with mild overcrowdings were randomly allocated to either a control group that was treated with conventional orthodontics or a test group that received piezo-assisted orthodontics. The piezocisions were performed 1 wk week after the placement of the orthodontic appliances. Neither grafting material nor sutures were used. All patients were followed every 2 wk, and archwires were changed only when they were no longer active. The periods required for the completion of the overall orthodontic treatments were calculated, and the periodontal parameters were evaluated at baseline and at the end of the orthodontic treatment. Patient-centered outcomes were assessed with a visual analog scale; analgesic use following the procedures was also recorded. RESULTS : The patient characteristics were similar between the 2 groups. The overall treatment time was significantly reduced by 43% in the piezocision group as compared with the control group. In both groups, periodontal parameters (i.e., recession depth, pocket depth, plaque index, and papilla bleeding index) remained unchanged between the baseline and treatment completion time points. No increase in root resorption was observed in either group. Scars were observed in 50% of the patients in the piezocision group. Analgesic consumption was similar following orthodontic appliance placement and piezocision surgery. Patient satisfaction was significantly better in the piezocision group than in the control group. CONCLUSION : In these conditions, the piezocision technique seemed to be effective in accelerating orthodontic tooth movement. No gingival recessions were observed. The risk of residual scars might limit the indications for piezocision in patients with a high smile line (ClinicalTrials.gov NCT02590835) [less ▲]

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See detailPregnancy outcome following frozen embryo transfer after artificial cycle or treatment by clomiphene citrate.
JOUAN, Caroline ULg; EMONARD, Violaine ULg; RUGGERI, Philippe ULg et al

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (2016), 29

The optimal method to prepare endometrium before frozen embryo transfer (FET) is not yet established. We retrospectively studied 4496 FET and detailed pregnancy and miscarriage rates in three groups of ... [more ▼]

The optimal method to prepare endometrium before frozen embryo transfer (FET) is not yet established. We retrospectively studied 4496 FET and detailed pregnancy and miscarriage rates in three groups of patients according to the endometrium preparation they have followed before their successive FET: clomifene citrate (CC, group 1), artificial cycle (AC, group 2) or switch between CC and AC (group 3). The overall pregnancy rates per transfer were 24.3, 20.8 and 17.3% while the miscarriage rates reached 23.2, 29.8 and 42.5%, respectively. Group 1 experienced the highest ongoing pregnancy rate (18.6%), the lowest being observed in group 3 (10.0%, p50.001). Here we propose several alternatives to improve our AC protocol (group 2) that seemed less effective than CC (group 1) and we consider the use of a gonadotrophinstimulated treatment for patients with the lowest reproductive outcomes (group 3). [less ▲]

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